Transformers: the changing phases of low-dimensional vanadium oxide bronzes.

PubMed

Marley, Peter M; Horrocks, Gregory A; Pelcher, Kate E; Banerjee, Sarbajit

2015-03-28

In this feature article, we explore the electronic and structural phase transformations of ternary vanadium oxides with the composition MxV2O5 where M is an intercalated cation. The periodic arrays of intercalated cations ordered along quasi-1D tunnels or layered between 2D sheets of the V2O5 framework induce partial reduction of the framework vanadium atoms giving rise to charge ordering patterns that are specific to the metal M and stoichiometry x. This periodic charge ordering makes these materials remarkably versatile platforms for studying electron correlation and underpins the manifestation of phenomena such as colossal metal-insulator transitions, quantized charge corrals, and superconductivity. We describe current mechanistic understanding of these emergent phenomena with a particular emphasis on the benefits derived from scaling these materials to nanostructured dimensions wherein precise ordering of cations can be obtained and phase relationships can be derived that are entirely inaccessible in the bulk. In particular, structural transformations induced by intercalation are dramatically accelerated due to the shorter diffusion path lengths at nanometer-sized dimensions, which cause a dramatic reduction of kinetic barriers to phase transformations and facilitate interconversion between the different frameworks. We conclude by summarizing numerous technological applications that have become feasible due to recent advances in controlling the structural chemistry and both electronic and structural phase transitions in these versatile frameworks.

The Changing Realities of Teacher Needs.

ERIC Educational Resources Information Center

Lightfoot, Alfred

1986-01-01

The teaching profession is facing a dramatic crisis as it attempts to deal with both "quantity" (teacher shortages, rising student enrollments, teacher persistence) and "quality" (teacher competence, teacher certification, teacher testing) problems. (CB)

Commentary on "Psychiatric Aspects of Child and Adolescent Obesity: A Review of the Past 10 Years"

ERIC Educational Resources Information Center

Fitzgibbon, Marian L.

2004-01-01

This article is a brief review of child and adolescent obesity over the past ten years. The starting point for the review is the well-known fact that there has been a dramatic rise in the prevalence of obesity among children, adolescents, and adults in the United Sates (Ogden et al., 2002). The rise has occurred across all age and ethnic groups,…

Understanding Coastal Wetland Vulnerability to Sea-Level Rise Enhanced Inundation Using Real-Time Stage Monitoring, LiDAR, and Monte Carlo Simulation in Everglades National Park

NASA Astrophysics Data System (ADS)

Cooper, H.; Zhang, C.

2017-12-01

Coastal wetlands are one of the most productive ecological systems in the world, providing critical habitat area and valuable ecosystem services such as carbon sequestration. However, due to their location in low lying areas, coastal wetlands are particularly vulnerable to sea-level rise (SLR). Everglades National Park (ENP) encompasses the southern-most portion of the Greater Everglades Ecosystem, and is the largest subtropical wetland in the USA. Water depths have shown to have a significant relationship to vegetation community composition and organization while also playing a crucial role in vegetation health throughout the Everglades. Live plants play a vital role in maintaining soil structure (i.e. elevation), and decreases in vegetation health can cause peat collapse or wetland loss resulting in dramatic habitat, organic soil, and elevation loss posing concerns for Everglades management and restoration. One suspected mechanism for peat collapse is enhanced inundation due to SLR, thus mapping and modeling water depths is a critical component to understanding the potential impacts of future SLR. Previous research in the Everglades focused on a conventional Water Depth Model (WDM) approach where a Digital Elevation Model (DEM) is subtracted from a Water Table Elevation Model (WTEM). In this study, the conventional WDM approach is extended to a more rigorous WDM technique so that the accuracy and precision of the underlying data may be considered. Monte Carlo simulation is used to propagate probability distributions through our SLR depth model using our Random Forest-based LiDAR DEM, Empirical Bayesian Kriging-based WTEMs, uncertainties in vertical datums, soil accretion projections, and regional sea-level rise projections. Water depth maps were produced for the wet and dry seasons in April and October, which successfully revealed the potential spatial and temporal water depth variations due to future SLR. It is concluded that a more rigorous WDM technique helps to increase the integrity of derived products used to support and guide coastal restoration managers and planners under the challenge of rising seas.

Sound of a cup with and without instant coffee

NASA Astrophysics Data System (ADS)

Morrison, Andrew; Rossing, Thomas D.

2002-05-01

An empty coffee cup, like an ancient Chinese two-tone bell, emits two distinctly different tones, depending upon where it is tapped. When it is filled with hot water, and some instant coffee is added, however, a whole new set of sounds is heard when the cup is tapped. The pitch rises an octave or more as the foam clears due to the dramatic change in the speed of sound in the bubble-filled liquid. A similar, but smaller, effect was noted in beer by Bragg [The World of Sound (1968)] and in hot chocolate by Crawford [Am. J. Phys. (1982)]. We describe the modes of vibration in a coffee cup and the sound emitted by a coffee cup as filled with instant coffee as the bubble density changes.

Charge/spin supercurrent and the Fulde-Ferrell state induced by crystal deformation in Weyl/Dirac superconductors

NASA Astrophysics Data System (ADS)

Matsushita, Taiki; Liu, Tianyu; Mizushima, Takeshi; Fujimoto, Satoshi

2018-04-01

It has been predicted that emergent chiral magnetic fields can be generated by crystal deformation in Weyl/Dirac metals and superconductors. The emergent fields give rise to chiral anomaly phenomena as in the case of Weyl semimetals with usual electromagnetic fields. Here, we clarify effects of the chiral magnetic field on Cooper pairs in Weyl/Dirac superconductors on the basis of the Ginzburg-Landau equation microscopically derived from the quasiclassical Eilenberger formalism. It is found that Cooper pairs are affected by the emergent chiral magnetic field in a dramatic way, and the pseudo-Lorentz force due to the chiral magnetic field stabilizes the Fulde-Ferrell state and causes a charge/spin supercurrent, which flows parallel to the chiral magnetic field in the case of Weyl/Dirac superconductors. This effect is in analogy with the chiral magnetic effect of Weyl semimetals. In addition, we elucidate that neither Meissner effect nor vortex state due to chiral magnetic fields occurs.

Real-time subway information for improving transit ridership.

DOT National Transportation Integrated Search

2016-08-01

In recent years, the standardization of transit schedule information has yielded a dramatic increase in the accessibility of computerized transit schedules and given rise to real-time service schedules. Two such real-time service schedules are the Ge...

Quantifying the impact of bathymetric changes on the hydrological regimes in a large floodplain lake: Poyang Lake

NASA Astrophysics Data System (ADS)

Yao, Jing; Zhang, Qi; Ye, Xuchun; Zhang, Dan; Bai, Peng

2018-06-01

The hydrological regime of a lake is largely dependent on its bathymetry. A dramatic water level reduction has occurred in Poyang Lake in recent years, coinciding with significant bed erosion. Few studies have focused on the influence of bathymetric changes on the hydrological regime in such a complex river-lake floodplain system. This study combined hydrological data and a physically based hydrodynamic model to quantify the influence of the bathymetric changes (1998-2010) on the water level spatiotemporal distribution in Poyang Lake, based on a dry year (2006), a wet year (2010) and an average year (2000-2010). The following conclusions can be drawn from the results of this study: (1) The bed erosion of the northern outlet channel averaged 3 m, resulting in a decrease in the water level by 1.2-2 m in the northern channels (the most significantly influenced areas) and approximately 0.3 m in the central lake areas during low-level periods. The water levels below 16 m and 14 m were significantly affected during the rising period and recession period, respectively. The water level reduction was enhanced due to lower water levels. (2) The water surface profiles adjusted, and the rising and recession rates of the water level increased by 0.5-3.1 cm/d at the lake outlet. The bathymetric influence extended across the entire lake due to the emptying effect, resulting in a change in the water level distribution. The average annual outflow increased by 6.8%. (3) The bathymetric changes contributed approximately 14.4% to the extreme low water level in autumn 2006 and enhanced the drought in the dry season. This study quantified the impact of the bathymetric changes on the lake water levels, thereby providing a better understanding of the potential effects of continued sand mining operations and providing scientific explanations for the considerable variations in the hydrological regimes of Poyang Lake. Moreover, this study attempts to provide a reference for the assessment of similarly dramatic bathymetric changes in complex floodplain lakes.

Body Snatchers.

PubMed

Andrews, Michelle

2016-10-01

Medical identity theft--when someone steals your personal data to get prescription drugs, doctor care, or surgery--is dramatically on the rise. Such a crime can endanger your own treatment and trash your finances. Learn who's most at risk and how to protect yourself from becoming a victim.

Drought stress suppresses phytoalexin production against Fusarium verticilliodes

USDA-ARS?s Scientific Manuscript database

Global climate change involves rising temperatures and potentially decreased rainfall or changes in rainfall patterns, which could dramatically decrease the yield of food crops. Drought alone can impair plant growth and development, but in nature plants are continuously exposed to both abiotic and b...

Glacier shrinkage and water resources in the Andes

NASA Astrophysics Data System (ADS)

Francou, Bernard; Coudrain, Anne

For more than a century glaciers around the world have been melting as air temperatures rise due to a combination of natural processes and human activity. The disappearance of these glaciers can have wide-ranging effects, such as the creation of new natural hazards or changes in stream flow that could threaten water suppliesSome of the most dramatic melting has occurred in the Andes mountain range in South America. To highlight the climatic and glacial change in the Andes and to encourage the scientific community to strengthen the glacier observation network that stretches from Colombia to the Patagonian ice fields, the Instituto Nacional de Recursos Naturales (INRENA), Perú, and the Institute of Research and Development (IRD), France, recently organized the second Symposium on Mass Balance of Andean Glaciers in Huaráz,Perú.

Simultaneous observation of free and defect-bound excitons in CH3NH3PbI3 using four-wave mixing spectroscopy

NASA Astrophysics Data System (ADS)

March, Samuel A.; Clegg, Charlotte; Riley, Drew B.; Webber, Daniel; Hill, Ian G.; Hall, Kimberley C.

2016-12-01

Solar cells incorporating organic-inorganic perovskite, which may be fabricated using low-cost solution-based processing, have witnessed a dramatic rise in efficiencies yet their fundamental photophysical properties are not well understood. The exciton binding energy, central to the charge collection process, has been the subject of considerable controversy due to subtleties in extracting it from conventional linear spectroscopy techniques due to strong broadening tied to disorder. Here we report the simultaneous observation of free and defect-bound excitons in CH3NH3PbI3 films using four-wave mixing (FWM) spectroscopy. Due to the high sensitivity of FWM to excitons, tied to their longer coherence decay times than unbound electron- hole pairs, we show that the exciton resonance energies can be directly observed from the nonlinear optical spectra. Our results indicate low-temperature binding energies of 13 meV (29 meV) for the free (defect-bound) exciton, with the 16 meV localization energy for excitons attributed to binding to point defects. Our findings shed light on the wide range of binding energies (2-55 meV) reported in recent years.

Commercialism in Schools. ERIC Digest.

ERIC Educational Resources Information Center

Larson, Kirstin

Businesses are increasingly making inroads into the classroom, particularly in underfunded schools. The dramatic rise in commercial activities in schools has sparked intense public debate, triggering a U.S. General Accounting Office (GAO) report and various regulatory attempts at district, state, and federal levels. This digest offers an overview…

A Psychoecological Model of Academic Performance among Hispanic Adolescents

ERIC Educational Resources Information Center

Chun, Heejung; Dickson, Ginger

2011-01-01

Although the number of students who complete high school continues to rise, dramatic differences in school success remain across racial/ethnic groups. The current study addressed Hispanic adolescents' academic performance by investigating the relationships of parental involvement, culturally responsive teaching, sense of school belonging, and…

An analysis of secular trends in method-specific suicides in Japan, 1950-1975.

PubMed

Yoshioka, Eiji; Saijo, Yasuaki; Kawachi, Ichiro

2017-04-05

In Japan, a dramatic rise in suicide rates was observed in the 1950s, especially among the younger population, and then the rate decreased rapidly again in the 1960s. The aim of this study was to assess secular trends in method-specific suicides by gender and age in Japan between 1950 and 1975. We paid special attention to suicides by poisoning (solid and liquid substances), and their contribution to dramatic swings in the overall suicide rate in Japan during the 1950s and 1960s. Mortality and population data were obtained from the Vital Statistics of Japan and Statistics Bureau, Ministry of Internal Affairs and Communications in Japan, respectively. We calculated method-specific age-standardized suicide rates by gender and age group (15-29, 30-49, or 50+ years). The change in the suicide rate during the research period was larger in males than females in all age groups, and was more marked among people aged 15-29 years compared to those aged 30-49 years and 50 years or over. Poisoning by solid and liquid substances overwhelmingly contributed to the dramatic change in the overall suicide rates in males and females aged 15-49 years in the 1950s and 1960s. For the peak years of the rise in poisoning suicides, bromide was the most frequently used substance. Our results for the 1950s and 1960s in Japan illustrated how assessing secular trends in method-specific suicides by gender and age could provide a deeper understanding of the dramatic swings in overall suicide rate. Although rapid increases or decreases in suicide rates have been also observed in some countries or regions recently, trends in method-specific suicides have not been analyzed because of a lack of data on method-specific suicide in many countries. Our study illustrates how the collection and analysis of method-specific data can contribute to an understanding of dramatic shifts in national suicide rates.

Folding and fracturing of rock adjacent to salt diapirs

NASA Astrophysics Data System (ADS)

Rowan, Mark G.

2017-04-01

When John Ramsay wrote his groundbreaking book in 1967, deformation around salt diapirs was not something he covered. At the time, most geologists considered diapirs to form due to density inversion, rising through thick overlying strata due to buoyancy. In doing so, salt was thought to shove aside the younger rocks, shearing and fracturing them in drag folds and supposedly producing "salt gouge". Even after it was realized that the majority of diapirs spend most of their history growing at or just beneath the surface, the relative rise of salt and sinking of minibasins were (and are) still thought by many to be accommodated in part by shear and fracturing of rocks in a collar zone around the salt. There are two arguments against this model. The first is mechanical: whereas halite behaves as a viscous fluid, even young sediment deforms as a brittle material with layer anisotropy. Thus, the salt-sediment interface is the outer margin of an intrasalt shear zone caused by viscous drag against the diapir margin. The velocity of salt flow decreases dramatically toward the edge of the diapir, so that the outermost salt effectively doesn't move. Hence, no shear or fracturing is expected in surrounding strata. The second and more important argument is that empirical field data do not support the idea of drag folds and associated deformation. Certainly, strata are typically folded and thinned adjacent to diapirs. However, stratal upturn is generated by monoclinal drape folding of the diapir roof over the edge of the rising salt, and thinning is caused by deposition onto the bathymetric highs formed by the diapirs, often supplemented by roof erosion and slumping. Halokinetic sequences observed in numerous salt basins (e.g., Paradox Basin, La Popa Basin, Spanish Pyrenees, Sivas Basin, Zagros Mountains, Kuqa Basin) contain no diapir-parallel shear zones and minimal thinning and fracturing caused by diapir rise. Even megaflaps, in which strata extend for kilometers up the sides of diapirs, have very little internal deformation. Instead, what faults are present around diapirs are related to drape folding (radial and diapir-parallel faults) or regional tectonics (extensional, contractional, strike-slip, and salt-evacuation faults).

Corporatizing Higher Education

ERIC Educational Resources Information Center

Lerner, Gerda

2008-01-01

The process of changing U.S. higher education institutions along a corporate model has been going on for several decades. It consists of changes, some open, some obscured, on various fronts: the erosion of tenure by attrition; the simultaneous increase in the use of contingent faculty; the rise in tuition; the dramatic decrease in federal and…

The Rise of the Life Narrative

ERIC Educational Resources Information Center

Goodson, Ivor

2006-01-01

In this article, the author discusses how narratives, which are part of the common currency of the day, have dramatically changed over the years. Grand narratives, which grew exponentially in the mid-nineteenth century, have now been replaced by two different narratives: life narratives and small-scale narratives. He also discusses how small…

The Rise of "Like" in Spontaneous Quotations

ERIC Educational Resources Information Center

Tree, Jean E. Fox; Tomlinson, John M., Jr.

2008-01-01

A comparison across spontaneous speech collected in the 1980s and the 2000s reveals a dramatic flip between the use of "said" versus "like" as enquoting devices. The greater use of "like" is reflected in a wide variety of quotation types including reported speech, thoughts, exclamations, and sounds. There is no…

Leaves: Elevated CO2 levels

USDA-ARS?s Scientific Manuscript database

Burning fossil fuels and land use changes such as deforestation and urbanization have led to a dramatic rise in the concentration of carbon dioxide (CO2) in the atmosphere since the onset of the Industrial Revolution. The highly dilute CO2 from the atmosphere enters plant leaves where it is concentr...

Promoting Value, Affordability, and Innovation in Cancer Drug Treatment - The Rising Cost of Cancer Drugs: Impact on Patients and Society

Cancer.gov

Innovative new drugs have improved outcomes for many cancer patients. But spending on cancer drugs has increased dramatically in recent years, placing a burden on cancer patients and a strain on health system and societal resources.

Voices from southern forests

Treesearch

H. Ken Cordell; John C. Bliss; Cassandra Y. Johnson; Mark Fly

1998-01-01

The faces and voices of the South have been changing dramatically over the last several decades, just like the rest of the Nation. Population growth, immigration, urbanization, expanding minority proportions, a thriving economy, rising environmental sentiments, and shifts in property ownership, among many other changes, have put forest and wildlife management in a much...

The Filipino Nursing Students' Dilemmas in Geriatric Care

ERIC Educational Resources Information Center

de Guzman, Allan B.; Cruz, Andrei Angelo R.; Cruz, Angela Laurice G.; Cruz, Robert Edward D.; Cuarto, Jose Mari Nino L.

2009-01-01

The continually rising percentage of the elderly population and the demand for geriatric nursing care are dramatically related. While it is true that most undergraduate programs prepare nurses for the care of geriatric patients, most receive limited academic preparation in the nursing curriculum (Williams & Mezey, 2000). This is particularly…

COMPARISON OF QPCR METHODS FOR THE DETECTION OF VITELLOGENIN EXPRESSION IN FATHEAD MINNOWS

EPA Science Inventory

Male fathead minnows (FHM) normally express little if any of the egg yolk precursor protein vitellogenin (Vg). However, when exposed to estrogenic compounds such as 17a-ethynylestradiol (EE2), transcriptional levels of Vg rise dramatically and result in decreased fecundity and i...

China-ASEAN Relations in Higher Education: An Analytical Framework

ERIC Educational Resources Information Center

Welch, Anthony

2012-01-01

China's dramatic economic rise has tended to overshadow other wider perspectives on the developing China and Association of Southeast Asian Nations (ASEAN) relationship, including in higher education. The article examines contemporary relations between China and ASEAN, set against the longer term development of cultural and trade relations. It is…

Opinion Leaders See Rising College Costs as Major Concern.

ERIC Educational Resources Information Center

Chronicle of Higher Education, 1988

1988-01-01

A recent survey of federal government officials, corporate leaders in charge of personnel and research, and journalists found dramatically different views in some areas, but agreement in concern about college costs, financing, and lack of government spending for research. Most felt college is a fair value for the cost. (MSE)

Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming.

PubMed

Sedegah, Martha; Hollingdale, Michael R; Farooq, Fouzia; Ganeshan, Harini; Belmonte, Maria; Huang, Jun; Abot, Esteban; Limbach, Keith; Chuang, Ilin; Tamminga, Cindy; Epstein, Judith E; Villasante, Eileen

2015-01-01

We have previously shown that a DNA-prime followed by an adenovirus-5 boost vaccine containing CSP and AMA1 (DNA/Ad) successfully protected 4 of 15 subjects to controlled human malaria infection (CHMI). However, the adenovirus-5 vaccine alone (AdCA) failed to induce protection despite eliciting cellular responses that were often higher than those induced by DNA/Ad. Here we determined the effect of CHMI on pre-CHMI cellular and antibody responses against CSP and AMA1 expressed as fold-changes in activities. Generally, in the DNA/Ad trial, CHMI caused pre-CHMI ELISpot IFN-γ and CD8+ T cell IFN-γ responses of the protected subjects to fall but among non-protected subjects, CHMI caused rises of pre-CHMI ELISpot IFN-γ but falls of CD8+ T cell IFN-γ responses. In contrast in the AdCA trial, CHMI caused both pre-CHMI ELISpot IFN-γ and CD8+ T cell IFN-γ responses of the AdCA subjects to fall. We suggest that the falls in activities are due to migration of peripheral CD8+ T cells to the liver in response to developing liver stage parasites, and this fall, in the DNA/Ad trial, is masked in ELISpot responses of the non-protected subjects by rises in other immune cell types. In addition, CHMI caused falls in antibody activities of protected subjects, but rises in non-protected subjects in both trials to CSP, and dramatically in the AdCA trial to AMA1, reaching 380 μg/ml that is probably due to boosting by transient blood stage infection before chloroquine treatment. Taken together, these results further define differences in cellular responses between DNA/Ad and AdCA trials, and suggest that natural transmission may boost responses induced by these malaria vaccines especially when protection is not achieved.

G-DRG Version 2009: new developments.

PubMed

Müller, Marcel L; Forschner, Andrea; Wenke, Andreas; Luger, Thomas A; Rompel, Rainer; Roeder, Norbert; Hensen, Peter

2009-04-01

The update of the G-DRG system for the year 2009 has been successfully negotiated. Like in the past years, changes are minimal and not dramatic, but they significantly enhance the quality of the DRG system. Once again, the German DRG system demonstrates its versatility and reliability for clinical reimbursement purposes. In the field of dermatology, several improvements or enhancements can be identified; the average case mix index that declined in the past years should now rise by 0.5 percent for 2009. Oncology cases are affected especially by this increase. Some refinements advanced for several years by the German Dermatologic Society (DDG) have been recognized --complex therapies like vacuum wound therapy, isolation due to multi-resistant infections and multiple primary tumors now have better cost weights. Although there still remain some minor problems like reimbursement of cost-intensive treatments, German dermatology is in summary very well prepared for the year 2009.

Mesoscale Particle-Based Model of Electrophoretic Deposition

DOE PAGES

Giera, Brian; Zepeda-Ruiz, Luis A.; Pascall, Andrew J.; ...

2016-12-20

In this paper, we present and evaluate a semiempirical particle-based model of electrophoretic deposition using extensive mesoscale simulations. We analyze particle configurations in order to observe how colloids accumulate at the electrode and arrange into deposits. In agreement with existing continuum models, the thickness of the deposit increases linearly in time during deposition. Resulting colloidal deposits exhibit a transition between highly ordered and bulk disordered regions that can give rise to an appreciable density gradient under certain simulated conditions. The overall volume fraction increases and falls within a narrow range as the driving force due to the electric field increasesmore » and repulsive intercolloidal interactions decrease. We postulate ordering and stacking within the initial layer(s) dramatically impacts the microstructure of the deposits. Finally, we find a combination of parameters, i.e., electric field and suspension properties, whose interplay enhances colloidal ordering beyond the commonly known approach of only reducing the driving force.« less

Capturing incentives and avoiding penalties

PubMed Central

Stevens, James C.

2013-01-01

Summary Over the past decade, health care in the United States has been a topic of intense political debate, resulting in dramatic legislative, regulatory, and economic changes. These changes have occurred due to the unsustainable rise of health care costs without accompanying improvement in measured health outcomes when compared to other economically developed countries. In an attempt to contain costs and improve the quality of health care provided, the Center for Medicare and Medicaid Services has implemented 4 distinct incentive-based programs. Data are scarce concerning whether such programs will be successful in accomplishing these goals. Each health care provider will need to weigh the costs of participation against the fines incurred by nonparticipation (up to 10% of annual Medicare payments). Knowledge of the percentage of one's practice dedicated to the care of patients in the Medicare and Medicaid programs will be helpful in arriving at a final decision. PMID:29473632

Mantle Sources Beneath the SW Indian Ridge - Remelting the African Superplume

NASA Astrophysics Data System (ADS)

Dick, H. J. B.; Zhou, H.

2012-04-01

The SW Indian Ridge runs some 7700 km from the Bouvet to the Rodgriguez Triple Junction, crossing over or near two postulated mantle plumes. The latter are associated with large oceanic rises where the ridge axis shoals dramatically in the vicinity of the mantle hotspot. The Marion Rise, extends 3100 km from the Andrew Bain FZ to near the Rodriguez TJ, with an along axis rise of 5600-m to it crest north of Marion Island. The rise has thin crust inferred on the basis of abundant exposures of mantle peridotites along its length. We suggest that this is the result of its sub-axial mantle source, which is a depleted residue originally emplaced by the African Superplume into the asthenosphere beneath southern Africa during the Karoo volcanic event ~185 Ma. Based on shallow mantle anisotropy, plate reconstructions, and hotspot traces, it now forms the mantle substrate for the SW Indian Ridge due to the breakup of Gondwanaland. The Marion Rise is associated with Marion Island, the present location of the Marion Hotspot, some 256 km south of the modern ridge. This plume is a vestigial remnant of the African Superplume now imbedded in and centered on asthenospheric mantle derived from the Karoo event. Based on the numerous large offset fracture zones, which would dam sub-axial asthenospheric flow along the ridge, the low postulated flux of the Marion plume, its off-axis position, and the thin crust along the ridge it is clear that the present day plume does not support the Marion Rise. Instead, this must be supported isostatically by the underlying mantle residue of the Karoo event. The Bouvet Rise is much shorter than the Marion Rise, extending ~664 km from the Conrad FZ on the American-Antarctic Ridge to the Shaka FZ on the SW Indian Ridge. It has ~3000-m of axial relief, peaking at Speiss Smt at Speiss Ridge: the last spreading segment of the SW Indian Ridge adjacent to the Bouvet TJ. Unlike the Marion plume, Bouvet is ridge-centered, and much of its rise is likely supported by sub-axial flow of hot mantle from the present-day plume. It is also clear from the isotopic composition of the Bouvet Plume that while it may also be a manifestation of the underlying seismic anomaly situated above D" that gave rise to the Marion Plume, this source must be compositionally heterogeneous at a very large scale. Secondary mantle heterogeneities are evident beyond those associated with the Marion and Bouvet Plumes. These likely explain the frequently extreme local isotopic variability of MORB along the SW Indian Ridge, and are likely due to entrainment of cratonic lithosphere from beneath Africa into the asthenosphere (e.g.: Meyzen et al., Nature, 2003). This is supported by major element anomalies in peridotites from adjacent to the 750-km offset Andrew Bain FZ, and by anomalously thick crust situated at Atlantis Bank, the site of an abrupt MORB isotopic anomaly, that suggest anomalously fertile mantle sources inconsistent with the regional basalt and peridotite major element compositional gradients attributed to the Superplume.

Algae as a Feedstock for Transportation Fuels. The Future of Biofuels?

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGill, Ralph

2008-05-15

Events in world energy markets over the past several years have prompted many new technical developments as well as political support for alternative transportation fuels, especially those that are renewable. We have seen dramatic rises in the demand for and production of fuel ethanol from sugar cane and corn and biodiesel from vegetable oils. The quantities of these fuels being used continue to rise dramatically, and their use is helping to create a political climate for doing even more. But, the quantities are still far too small to stem the tide of rising crude prices worldwide. In fact, the usemore » of some traditional crops (corn, sugar, soy, etc.) in making fuels instead of food is apparently beginning to impact the cost of food worldwide. Thus, there is considerable interest in developing alternative biofuel feedstocks for use in making fuels -- feedstocks that are not used in the food industries. Of course, we know that there is a lot of work in developing cellulosic-based ethanol that would be made from woody biomass. Process development is the critical path for this option, and the breakthrough in reducing the cost of the process has been elusive thus far. Making biodiesel from vegetable oils is a well-developed and inexpensive process, but to date there have been few reasonable alternatives for making biodiesel, although advanced processes such as gasification of biomass remain an option.« less

Spotlight: Iraq.

PubMed

De Sherbinin, A

1990-10-01

Largely due to government-sponsored pronatalist measures, Iraq possesses the highest natural increase rate of any country, 3.9% a situation that could lead to serous problems in the future. Iraq's population currently stand at 19 million (75-80% are Iraqi Arabs, 15-20% Kurds, and 5% other minorities), but at the present rate of growth, it could double in less than 20 years. Prior to its recent invasion of Kuwait, Iraq was also host to about 1 million foreign workers. About 95% of the country's revenues come from oil export; agriculture accounts for only 10% of its Gross National Product. With Saddam Hussein's rise to power in 1979, Iraq embarked on a plan of rapid population growth, seen as necessary step to better exploit the country's agricultural and mineral resources. Among the pronatalist measures, the government grants women 100% paid maternity leave during the first 10 weeks and restricts access to contraceptives. The aim is for married women to have at least 4 children. Besides increasing fertility, the government has also succeeded in lowering mortality levels by improving maternal and child health care. The dramatic rise in population growth could have serious consequences. Iraq could face serious water shortages in the near future, once Turkey completes its Ataturk dam in the Euphrates river. A greater population will only place a greater demand on the availability of water.

Three Essays on Chinese IT Service Industry: Capability Development, Internationalization Strategy, and Cultural Templates

ERIC Educational Resources Information Center

Su, Ning

2011-01-01

Leading Chinese technology firms, from automobile manufacturer to information service provider, are evolving into some of the world's most innovative and competitive players, and dramatically changing the global business landscape. What underlies the rise of these firms is China's national strategy of transforming itself from a low-cost…

Effects of climate change on forest insect and disease outbreaks

Treesearch

David W. Williams; Robert P. Long; Philip M. Wargo; Andrew M. Liebhold

2000-01-01

General circulation models (GCMs) predict dramatic future changes in climate for the northeastern and north central United States under doubled carbon dioxide (CO2) levels (Hansen et al., 1984; Manabe and Wetherald, 1987; Wilson and Mitchell, 1987; Cubasch and Cess, 1990; Mitchell et al., 1990). January temperatures are projected to rise as much...

Learning Sustainability by Developing a Solar Dryer for Microalgae Retrieval

ERIC Educational Resources Information Center

Malheiro, Benedita; Ribeiro, Cristina; Silva, Manuel F.; Caetano, Nídia; Paulo Ferreira,; Guedes, Pedro

2015-01-01

The development of nations depends on energy consumption, which is generally based on fossil fuels. This dependency produces irreversible and dramatic effects on the environment, e.g. large greenhouse gas emissions, which in turn cause global warming and climate changes, responsible for the rise of the sea level, floods, and other extreme weather…

Efficacy of glyphosate and halosulfuron for control of purple and yellow nutsedge in elevated CO2 environments

USDA-ARS?s Scientific Manuscript database

Carbon dioxide (CO2) concentrations in the earth’s atmosphere have continually increased each year since the beginning of the Industrial revolution and are expected to continue rising in the future, which could have a dramatic impact on agricultural production. Previous research has shown that eleva...

Building a Business Case for Going Green

ERIC Educational Resources Information Center

Harris, Bill; Maldeis, Neil

2011-01-01

Community college enrollments usually rise during tough economic times and the recent recession and slow recovery are no exception. According to the American Association of Community Colleges (AACC), the number of students attending community colleges has grown dramatically in the last decade to about 12.4 million last fall. The AACC says that 1.4…

The Geopolitics and Meanings of India's Massive Skills Development Ambitions

ERIC Educational Resources Information Center

King, Kenneth

2012-01-01

This paper interrogates the drivers and meanings behind the dramatic rise of technical and vocational education and training in the policy and political agenda of India. What are the assumptions about the existing traditions and character of India's culture or cultures of skills development? Is the massive planned expansion of skilled people in…

Factors Affecting Use of Instant Messaging Software by Information Technology Professionals

ERIC Educational Resources Information Center

Pratt, Robert C.

2010-01-01

Instant messaging systems--a type of social networking technology that connects people who are physically separated but working together--have seen a dramatic rise in use in globally dispersed organizations, yet there is an absence of academic research in predictive factors of instant messaging adoption. This study examined the factors influencing…

Rise of the Science and Engineering Postdoctorate and the Restructuring of Academic Research

ERIC Educational Resources Information Center

Cantwell, Brendan; Taylor, Barrett J.

2015-01-01

Since the 1980s the number of postdocs employed at U.S. research universities has increased dramatically as has the importance of postdocs to academic research. Growth in postdoc employment has coincided with increased dependence on external research funds. Using panel regression analysis, this article explores the organizational characteristics…

Setting an Agenda for Social Justice through Leadership Development

ERIC Educational Resources Information Center

Brundrett, Mark; de Cuevas, Rachel Anderson

2007-01-01

The profile, status and funding of leadership development has risen dramatically both in the UK and internationally over the last decade. In England this has been denoted by the rise of national programmes of leadership development and the creation of the National College for School Leadership (NCSL). Although the original inception of such…

The Secret to Finland's Success: Educating Teachers. Research Brief

ERIC Educational Resources Information Center

Sahlberg, Pasi

2010-01-01

In the last decade, Finland has emerged as the leading OECD country in educational achievement. In examining the sources of Finland's dramatic rise to the top, research shows one key element that has impacted Finland's success above all others: excellent teachers. This policy brief details the key elements of Finland's successful system, examining…

The Rise and Demise of the International Council for Science Policy Studies (ICSPS) as a Cold War Bridging Organization

ERIC Educational Resources Information Center

Elzinga, Aant

2012-01-01

When the journal "Minerva" was founded in 1962, science and higher educational issues were high on the agenda, lending impetus to the interdisciplinary field of "Science Studies" "qua" "Science Policy Studies." As government expenditures for promoting various branches of science increased dramatically on…

Wind Energy Systems.

ERIC Educational Resources Information Center

Conservation and Renewable Energy Inquiry and Referral Service (DOE), Silver Spring, MD.

During the 1920s and 1930s, millions of wind energy systems were used on farms and other locations far from utility lines. However, with passage of the Rural Electrification Act in 1939, cheap electricity was brought to rural areas. After that, the use of wind machines dramatically declined. Recently, the rapid rise in fuel prices has led to a…

iNACOL Blended Learning Teacher Competency Framework

ERIC Educational Resources Information Center

Powell, Allison; Rabbitt, Beth; Kennedy, Kathryn

2014-01-01

In recent years there has been a dramatic rise in interest and early adoption of blended learning to improve the educational experiences of students. A great amount of work has been done to codify approaches, with tools and resources emphasizing the structural components of new models, such as the configuration of physical learning space, use of…

Indiana State University Graduates to Advanced Plastic Cooling Towers

ERIC Educational Resources Information Center

Sullivan, Ed

2012-01-01

Perhaps more than many other industries, today's universities and colleges are beset by dramatically rising costs on every front. One of the areas where overhead can be contained or reduced is in the operation of the chilled water systems that support air conditioning throughout college campuses, specifically the cooling towers. Like many…

Small Town Renewal: Overview and Case Studies.

ERIC Educational Resources Information Center

Kenyon, Peter, Ed.; Black, Alan, Ed.

Many small, inland, and remote Australian rural communities continue to lose population and businesses, a trend that has intensified over the last 2 decades. Mean age continues to rise, while the 15-24 age group contracts dramatically. Such declining demographics are caused by the stress and uncertainty of volatile world commodity markets, as well…

The osteogenic capacity of biomimetic hierarchical micropore/nanorod-patterned Sr-HA coatings with different interrod spacings.

PubMed

Zhou, Jianhong; Li, Bo; Han, Yong; Zhao, Lingzhou

2016-07-01

Advanced titanium based bone implant with fast established, rigid and stable osseointegration is stringently needed in clinic. Here the hierarchical micropore/nanorod-patterned strontium doped hydroxyapatite (Ca9Sr1(PO4)6(OH)2, Sr1-HA) coatings (MNRs) with different interrod spacings varying from about 300 to 33nm were developed. MNRs showed dramatically differential biological performance closely related to the interrod spacing. Compared to micropore/nanogranule-patterned Sr1-HA coating (MNG), MNRs with an interrod spacing of larger than 137nm resulted in inhibited in vitro mesenchymal stem cell functions and in vivo osseointegration, while those of smaller than 96nm gave rise to dramatically enhanced the biological effect, especially those of mean 67nm displayed the best effect. The differential biological effect of MNRs was related to their modulation on the focal adhesion mediated mechanotransduction. These results suggest that MNRs with a mean interrod spacing of 67nm may give rise to an advanced implant of improved clinical performance. Copyright © 2016 Elsevier Inc. All rights reserved.

Estimation of osmotic parameters accompanying zeatin-induced growth of detached cucumber cotyledons.

PubMed

Rayle, D L; Ross, C W; Robinson, N

1982-12-01

Water potential (psi), the osmotic potential (psi(pi)), and the pressure potential (psi(p)) of detached cotyledons isolated from Cucumis sativus L. cv Marketer seedlings after 0, 1.5, and 3 days growth with and without zeatin were determined. From zero time to 3 days, cotyledons incubated without exogenous zeatin exhibited a slight decrease in psi (from -0.4 to -1.0 bars), while those grown with zeatin developed even more negative values (about -4 bars). Both groups showed rising psi(pi) values (decreases in solutes per unit volume), but this rise was more dramatic in those treated with zeatin. These data indicate that the capacity of zeatin-treated cotyledons to take up water more rapidly than controls and thus expand faster must be due to wall loosening, as reflected in psi(p) values which declined during 3 days from about +11 bars to about +1.4 bars.It was also found that freshly detached cotyledons or those grown without exogenous zeatin exhibited osmoregulation in polyethylene glycol (PEG) solutions. That is, while cotyledons initially lost H(2)O into certain PEG solutions, their psi values decreased over time and they began absorbing water after 1 to 4 hours. After 3 days growth, zeatin-treated cotyledons had lost most of this capacity of osmoregulate. It seems likely that osmoregulation in cotyledons not treated with zeatin is due to wall loosening rather than changes in psi(pi). Zeatin-treated cotyledons with already loosened walls may not have this option to deal with water stress and thus simply come to equilibrium with external PEG solutions.

Hurricanes, sea level rise, and coastal change

USGS Publications Warehouse

Sallenger,, Asbury H.; Wang, Ping; Rosati, Julie D.; Roberts, Tiffany M.

2011-01-01

Sixteen hurricanes have made landfall along the U.S. east and Gulf coasts over the past decade. For most of these storms, the USGS with our partners in NASA and the U.S. Army Corps of Engineers have flown before and after lidar missions to detect changes in beaches and dunes. The most dramatic changes occurred when the coasts were completely submerged in an inundation regime. Where this occurred locally, a new breach was cut, like during Hurricane Isabel in North Carolina. Where surge inundated an entire island, the sand was stripped off leaving marshy outcrops behind, like during Hurricane Katrina in Louisiana. Sea level rise together with sand starvation and repeated hurricane impacts could increase the probabilities of inundation and degrade coasts more than sea level rise alone.

Common-path interference and oscillatory Zener tunneling in bilayer graphene p-n junctions

PubMed Central

Nandkishore, Rahul; Levitov, Leonid

2011-01-01

Interference and tunneling are two signature quantum effects that are often perceived as the yin and yang of quantum mechanics: a particle simultaneously propagating along several distinct classical paths versus a particle penetrating through a classically inaccessible region via a single least-action path. Here we demonstrate that the Dirac quasiparticles in graphene provide a dramatic departure from this paradigm. We show that Zener tunneling in gapped bilayer graphene, which governs transport through p-n heterojunctions, exhibits common-path interference that takes place under the tunnel barrier. Due to a symmetry peculiar to the gapped bilayer graphene bandstructure, interfering tunneling paths form conjugate pairs, giving rise to high-contrast oscillations in transmission as a function of the gate-tunable bandgap and other control parameters of the junction. The common-path interference is solely due to forward-propagating waves; in contrast to Fabry–Pérot-type interference in resonant-tunneling structures, it does not rely on multiple backscattering. The oscillations manifest themselves in the junction I–V characteristic as N-shaped branches with negative differential conductivity. The negative dI/dV, which arises solely due to under-barrier interference, can enable new high-speed active-circuit devices with architectures that are not available in electronic semiconductor devices. PMID:21825159

Child Care in the 1980's: Exploring New Resources.

ERIC Educational Resources Information Center

Virginia State Div. for Children, Richmond.

Because resources from the federal government will continue to diminish, and because rising costs and inflation could make quality child care services more scarce and expensive than they are at present, it is crucial to examine new alternatives for meeting child care needs in the 1980's. Dramatic changes in the structure of the American family in…

Using Action Learning to Support Individual and Organisational Reflection in an International Development and Relief Agency

ERIC Educational Resources Information Center

Wright, Nick

2004-01-01

The dramatic rise in popularity of action learning (AL) over recent years has provided opportunity and impetus for various applications of this approach to be developed and tested in practice. This article describes one organisation's experience of AL, demonstrating that it can be effective in terms of stimulating and supporting reflective…

Consequences of salinity and freezing stress for two populations of Quercus virginiana Mill

Treesearch

Cassandra M. Kurtz; Jessica A. Savage; I-Yu Huang; Jeannine Cavender-Bares

2013-01-01

Climate change is of increasing concern in coastal forests where rising sea levels could lead to dramatic shifts in ecosystem composition. To investigate how inundation may impact coastal ecosystems, we examined the sensitivity of Quercus virginiana Mill., a dominant tree in the southeastern U.S., to increased soil salinity and examined whether high...

Invited Commentary: Childhood and Adolescent Obesity--Psychological and Behavioral Issues in Weight Loss Treatment

ERIC Educational Resources Information Center

Sarwer, David B.; Dilks, Rebecca J.

2012-01-01

The prevalence of childhood and adolescent obesity has tripled in the past three decades. This increase has been accompanied by a dramatic rise in obesity-related health complications among American youth. Thus, many obese youth are now experiencing illnesses that will threaten their life expectancy in the absence of significant weight loss.…

Introducing Educational Technologies to Teachers: Experience Report

ERIC Educational Resources Information Center

Thota, Neena; Negreiros, Joao G. M.

2015-01-01

The dramatic rise in use of digital media has changed the way learning is taking place and has led to new ways to teach with digital technologies. In this article, we describe the experiences of teaching a course that introduces educational technologies to teachers in Macau. The course design is based on connectivism, a learning theory for the…

Reforming BTECs: Applied General Qualifications as a Route to Higher Education. HEPI Report 94

ERIC Educational Resources Information Center

Kelly, Scott

2017-01-01

The dramatic rise in the number of university students holding BTECs [Business and Technology Education Councils] raises important questions about the purpose of the qualification and whether it should be treated by policymakers as part of an academic or vocational pathway. Scott Kelly discusses these issues and makes a number of recommendations…

Disrupting Law School: How Disruptive Innovation Will Revolutionize the Legal World

ERIC Educational Resources Information Center

Pistone, Michele R.; Horn, Michael B.

2016-01-01

Facing dramatic declines in enrollment, revenue, and student quality at the same time that their cost structure continues to rise and public support has waned, law schools are in crisis. A key driver of the crisis is shrinking employment opportunities for recent graduates, which stem in part from the disruption of the traditional business model…

Suicidality in African American Men: The Roles of Southern Residence, Religiosity, and Social Support

ERIC Educational Resources Information Center

Wingate, LaRicka R.; Bobadilla, Leonardo; Burns, Andrea B.; Cukrowicz, Kelly C.; Hernandez, Annya; Ketterman, Rita L.; Minnix, Jennifer; Petty, Scharles; Richey, J. Anthony; Sachs-Ericsson, Natalie; Stanley, Sheila; Williams, Foluso M.; Joiner, Thomas E., Jr.

2005-01-01

The rise in suicide by African Americans in the United States is directly attributable to the dramatic, nearly three-fold increase in suicide rates of African American males. Gibbs (1997) hypothesized high social support, religiosity, and southern residence are protective factors against suicidality for Black people. This hypothesis was tested…

Effect of dynamic temperature storage in retail display case on the quality and microbiota of packaged fresh-cut leafy greens

USDA-ARS?s Scientific Manuscript database

Commercial refrigeration equipment is projected to rise 5.2% annually to meet the consumer demand for fresh-cut produce items. The highly variable temperature conditions associated with storage of fresh-cuts in commercial open-refrigerated display cases dramatically affects the shelf-life and qualit...

Policy Options for Managing International Student Migration: The Sending Country's Perspective

ERIC Educational Resources Information Center

Gribble, Cate

2008-01-01

A consequence of the dramatic rise in international student mobility is the trend for international students to remain in the country in which they study after graduation. Countries such as Australia, the UK and Canada stand to benefit from international student migration, as they are able to fill skill shortages with locally trained foreign…

Brutal Borders? Examining the Treatment of Deportees during Arrest and Detention

ERIC Educational Resources Information Center

Phillips, Scott; Hagan, Jacqueline Maria; Rodriguez, Nestor

2006-01-01

Recent legislation has produced a dramatic rise in the detention and removal of immigrants from the United States. Drawing on interviews with a random sample of Salvadoran deportees, we examine treatment during arrest and detention. Our findings indicate: (1) deportees are often subject to verbal harassment, procedural failings and use of force;…

Screen Capture Technology: A Digital Window into Students' Writing Processes

ERIC Educational Resources Information Center

Seror, Jeremie

2013-01-01

Technological innovations and the prevalence of the computer as a means of producing and engaging with texts have dramatically transformed how literacy is defined and developed in modern society. This rise in digital writing practices has led to a growing number of tools and methods that can be used to explore second language (L2) writing…

Risk and Resilience in Orphaned Adolescents Living in a Community Affected by AIDS

ERIC Educational Resources Information Center

Wild, Lauren G.; Flisher, Alan J.; Robertson, Brian A.

2013-01-01

The AIDS pandemic has resulted in a dramatic rise in the number of orphans in South Africa. This study was designed to investigate the associations between family, peer, and community factors and resilience in orphaned adolescents. Self-report questionnaires were administered verbally to 159 parentally bereaved adolescents (aged 10-19) in an…

Beyond the "c" and the "x": Learning with Algorithms in Massive Open Online Courses (MOOCs)

ERIC Educational Resources Information Center

Knox, Jeremy

2018-01-01

This article examines how algorithms are shaping student learning in massive open online courses (MOOCs). Following the dramatic rise of MOOC platform organisations in 2012, over 4,500 MOOCs have been offered to date, in increasingly diverse languages, and with a growing requirement for fees. However, discussions of "learning" in MOOCs…

Defined contribution: a part of our future.

PubMed Central

Baugh, Reginald F.

2003-01-01

Rising employer health care costs and consumer backlash against managed care are trends fostering the development of defined contribution plans. Defined contribution plans limit employer responsibility to a fixed financial contribution rather than a benefit program and dramatically increase consumer responsibility for health care decision making. Possible outcomes of widespread adoption of defined contribution plans are presented. PMID:12934869

Suicide Notes in Mexico: What Do They Tell Us?

ERIC Educational Resources Information Center

Chavez-Hernandez, Ana-Maria; Paramo, Daniel; Leenaars, Antoon A.; Leenaars, Lindsey

2006-01-01

According to international and Mexican official statistics, there is a dramatic rise in suicide in Mexico; however, research in this area is severely limited. This is the first study of suicide notes from Mexico in the international literature. From a population of 747 registered suicides, a sample of 106 note-writers and 106 nonnote writers was…

Socioeconomic Status and the Increased Prevalence of Autism in California

ERIC Educational Resources Information Center

King, Marissa D.; Bearman, Peter S.

2011-01-01

The prevalence of autism has increased precipitously--roughly 10-fold in the past 40 years--yet no one knows exactly what caused this dramatic rise. Using a large and representative dataset that spans the California birth cohorts from 1992 through 2000, we examine individual and community resources associated with the likelihood of an autism…

On the history of New York Medical College.

PubMed

Greenberg, S J

1986-01-01

The history of New York Medical College reflects three distinct trends in the development of medical education: the rise and fall of homeopathy, the input of civic leaders (in this case, William Cullen Bryant) and the uneasy relationship between medical schools and hospitals caused by the dramatic increase in the complexity and cost of hospital care.

How the Media Misleads the Story of School Consumerism: A Perspective from School Finance

ERIC Educational Resources Information Center

Killeen, Kieran

2007-01-01

Noting the dramatic rise in media reporting on the topic of school commercialism and consumer activity in schools, this research explores the fiscal benefits of such activities. Though a variety of activities frequently associated with school consumerism generate revenues for schools, in the example of student activity fees there is very little…

"Betwixt Brewings": A History of College Students and Alcohol, 1820-1933

ERIC Educational Resources Information Center

Hevel, Michael Stephen

2011-01-01

This dissertation offers a history of white college students' relationship with alcohol between 1820 and 1933. The years that frame this study represent a long crisis regarding alcohol in the United States. A dramatic rise in alcohol consumption began around 1800, the negative consequences of which led growing numbers of Americans, for the first…

Technology and the Broken Higher Education Cost Model: Insights from the Delta Cost Project

ERIC Educational Resources Information Center

Kirshstein, Rita; Wellman, Jane

2012-01-01

Although U.S. higher education has faced numerous crises and dilemmas in its history, the situation in which colleges and universities find themselves at the moment is indeed different. Shrinking public subsidies coupled with historic rises in tuitions come at the same time that colleges and universities have been tasked to dramatically increase…

Comparison of TiO2 nanoparticle and graphene-TiO2 nanoparticle composite phototoxicity to Daphnia magna and Oryzias latipes

EPA Science Inventory

With a dramatic rise in complexity, needs of nanotoxicology research go beyond simple forms of nanomaterials. This study compared the phototoxicity of nano-TiO2and graphene-TiO2 nanocomposite (GNP). GNP was synthesized based on a hydrothermal method, which simultaneously performe...

Being a Mobile International Postgraduate Research Student with Family in the United Kingdom: Conflict, Contestation and Contradictions

ERIC Educational Resources Information Center

Mwale, Shadreck; Alhawsawi, Sajjadllah; Sayed, Yusuf; Rind, Irfan. A.

2018-01-01

The internationalisation of higher education has influenced the dramatic rise in the mobility of students, academics and knowledge across borders. There has been growing research interest focusing on international students studying abroad. While the student experience is an area of education that is often researched, most research focuses on…

76 FR 37647 - Safety Zone; Missouri River From the Border Between Montana and North Dakota

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... destruction, loss or injury due to hazards associated with rising flood water. Operation in this zone is... vessels from destruction, loss or injury due to the hazards associated with rising flood water. The... destruction, loss or injury due to the hazards associated with rising flood water. If you are a small business...

Casino taxation in macao: an economic perspective.

PubMed

Gu, Xinhua; Tam, Pui Sun

2011-12-01

Macao's gaming industry has experienced dramatic growth for 8 years, yet with certain social costs due to compulsive gambling. The government has come under pressure for tax cuts even though its gaming receipts are falling relatively to the casino retained revenue. The request for tax relief is triggered by a recent decline in net profit despite fast growing gross gaming revenue under favorable market conditions. This is very likely caused by a substantial hike in casino operating costs due to increased competition and might also signal the presence of the principal-agent problem. Given the regressivity of gaming tax with respect to net profit, it is no surprise that casinos with lower profitability are more prone to seek tax cuts. The source of Macao gaming profit hinges on three distinct factors: rising demand from China, monopoly location for casinos, and market structure of oligopoly. These factors provide economic justifications for the current tax regime of Macao with a strong ability to pass tax burdens on to massive visitors. The government relies on casino tax revenue to deal with gambling related problems and promote local diversified development. Pushing for tax variability may create policy instability, business uncertainty, and unpredictable prosperity in the long term.

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

PubMed Central

Oliver, William R.; Shenk, Jennifer L.; Snaith, Mike R.; Russell, Caroline S.; Plunket, Kelli D.; Bodkin, Noni L.; Lewis, Michael C.; Winegar, Deborah A.; Sznaidman, Marcos L.; Lambert, Millard H.; Xu, H. Eric; Sternbach, Daniel D.; Kliewer, Steven A.; Hansen, Barbara C.; Willson, Timothy M.

2001-01-01

The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs and the antidiabetic effects of the glitazone drugs in humans are due to activation of the α (NR1C1) and γ (NR1C3) subtypes, respectively. By contrast, the therapeutic potential of the δ (NR1C2) subtype is unknown, due in part to the lack of selective ligands. We have used combinatorial chemistry and structure-based drug design to develop a potent and subtype-selective PPARδ agonist, GW501516. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux. When dosed to insulin-resistant middle-aged obese rhesus monkeys, GW501516 causes a dramatic dose-dependent rise in serum high density lipoprotein cholesterol while lowering the levels of small-dense low density lipoprotein, fasting triglycerides, and fasting insulin. Our results suggest that PPARδ agonists may be effective drugs to increase reverse cholesterol transport and decrease cardiovascular disease associated with the metabolic syndrome X. PMID:11309497

What Works (and What Does Not) in Youth Violence Prevention: Rethinking the Questions and Finding New Answers

ERIC Educational Resources Information Center

Guerra, Nancy G.; Boxer, Paul; Cook, Clayton R.

2006-01-01

Dramatic rises in youth violence in the United States beginning in the 1980s coupled with high visibility acts such as school shootings have resulted in a corresponding proliferation of programs designed to prevent aggression and violence in children and youth. Parallel with this increasing programmatic expansion, there have been repeated calls…

Women's Rising Share of Tertiary Enrollment: A Cross-National Analysis

ERIC Educational Resources Information Center

McDaniel, Anne

2014-01-01

In recent decades, a dramatic shift occurred in higher education throughout the world. Women now enroll in and complete more education than men in the majority of countries. Using a lagged cross-sectional design on a dataset of 75 countries from 1990 to 2008, this study examines the predictors of the current gender gap in tertiary enrollment. I…

New! Improved? The Transformation of the Global Agrifood System

ERIC Educational Resources Information Center

Busch, Lawrence; Bain, Carmen

2004-01-01

The last decade has witnessed a dramatic rise in global trade in food and agricultural products. While much analysis has focused on the role of the world Trade Organization (WTO) in this process, we argue that other forms of regulation are of far greater consequence. In this paper, we examine changes in the agrifood system made possible by the…

The south's timer export potential

Treesearch

James E. Granskog

1986-01-01

Exports of southern wood products have bccil dcclirling since 1980, following a dramatic rise during the 1970s. The value of these exports rose from near the $50 million level in the early 1970s to almost $500 million in 1980, but has dropped by more than a third since then. Now, however, changing monetary conditions appear to be turning the trend upward again....

Perceived Racism, Discrimination, and Acculturation in Suicidal Ideation and Suicide Attempts among Black Young Adults

ERIC Educational Resources Information Center

Castle, Kathryn; Conner, Kenneth; Kaukeinen, Kimberly; Tu, Xin

2011-01-01

During young adulthood the suicide rate among Blacks rises dramatically and approaches that of the U.S. general population, requiring that prevention efforts include a focus on Black young adults. Although most research on suicidality among Blacks has focused on risk factors observed in the dominant culture, in this study the authors examined…

The Impact of Physical Education on Obesity among Elementary School Children. NBER Working Paper No. 18341

ERIC Educational Resources Information Center

Cawley, John; Frisvold, David; Meyerhoefer, Chad

2012-01-01

In response to the dramatic rise in childhood obesity, the Centers for Disease Control (CDC) and other organizations have advocated increasing the time that elementary school children spend in physical education (PE) classes. However, little is known about the effect of PE on child weight. This paper measures that effect by instrumenting for child…

Pathology of wildfire risk: A characterization of social and ecological dimensions

Treesearch

A. Paige Fischer; Thomas A Spies; Toddi A Steelman; Cassandra Moseley; Bart R Johnson; John D Bailey; Alan A Ager; Patrick Bourgeron; Susan Charnley; Brandon M Collins; Jeffrey D Kline; Jessica E Leahy; Jeremy S Littell; James DA Millington; Max Nielsen-Pincus; Christine S Olsen; Travis B Paveglio; Christopher I Roos; Michelle M Steen-Adams; Forrest R Stevens; Jelena Vukomanovic; Eric M White; David M. J. S. Bowman

2016-01-01

Despite dramatic increases in suppression spending, the risk of life and property loss associated with wildfire has continued to rise in recent decades. Economic losses from wildfires have doubled in the United States and suppression expenses have tripled between 2002 and 2012 compared to the decade prior. Loss of property to wildfire has outpaced efforts to reduce...

Using Science Camps to Develop Understandings about Scientific Inquiry--Taiwanese Students in a U.S. Summer Science Camp

ERIC Educational Resources Information Center

Antink-Meyer, Allison; Bartos, Stephen; Lederman, Judith S.; Lederman, Norman G.

2016-01-01

Recent years have witnessed a dramatic rise in the number of middle and high school students from Asian countries participating in U.S.-based summer experiences (Perlez & Gao, 2013). Although summer science camps have been shown to improve students' attitudes and interests related to science and science learning (Bhattacharyya, Mead &…

The Provision and Completion of Gender-Specific Services for Girls on Probation: Variation by Race and Ethnicity

ERIC Educational Resources Information Center

Wolf, Angela M.; Graziano, Juliette; Hartney, Christopher

2009-01-01

Beginning in the late 1980s, the number of girls entering the juvenile justice system increased dramatically. Although historically girls had entered the justice system with status offenses, recent examinations suggest a sharp rise in the number of girls charged with more serious crimes. Researchers and policy makers have increasingly acknowledged…

Estimation of Osmotic Parameters Accompanying Zeatin-Induced Growth of Detached Cucumber Cotyledons 1

PubMed Central

Rayle, David L.; Ross, Cleon W.; Robinson, Nina

1982-01-01

Water potential (ψ), the osmotic potential (ψπ), and the pressure potential (ψp) of detached cotyledons isolated from Cucumis sativus L. cv Marketer seedlings after 0, 1.5, and 3 days growth with and without zeatin were determined. From zero time to 3 days, cotyledons incubated without exogenous zeatin exhibited a slight decrease in ψ (from −0.4 to −1.0 bars), while those grown with zeatin developed even more negative values (about −4 bars). Both groups showed rising ψπ values (decreases in solutes per unit volume), but this rise was more dramatic in those treated with zeatin. These data indicate that the capacity of zeatin-treated cotyledons to take up water more rapidly than controls and thus expand faster must be due to wall loosening, as reflected in ψp values which declined during 3 days from about +11 bars to about +1.4 bars. It was also found that freshly detached cotyledons or those grown without exogenous zeatin exhibited osmoregulation in polyethylene glycol (PEG) solutions. That is, while cotyledons initially lost H2O into certain PEG solutions, their ψ values decreased over time and they began absorbing water after 1 to 4 hours. After 3 days growth, zeatin-treated cotyledons had lost most of this capacity of osmoregulate. It seems likely that osmoregulation in cotyledons not treated with zeatin is due to wall loosening rather than changes in ψπ. Zeatin-treated cotyledons with already loosened walls may not have this option to deal with water stress and thus simply come to equilibrium with external PEG solutions. PMID:16662734

Socioeconomic Drivers of PM2.5 in the Accumulation Phase of Air Pollution Episodes in the Yangtze River Delta of China

PubMed Central

Lou, Cai-Rong; Liu, Hong-Yu; Li, Yu-Feng; Li, Yu-Ling

2016-01-01

Recent studies in PM2.5 sources show that anthropogenic emissions are the main contributors to haze pollution. Due to their essential roles in establishing policies for improving air quality, socioeconomic drivers of PM2.5 levels have attracted increasing attention. Unlike previous studies focusing on the annual PM2.5 concentration (Cyear), this paper focuses on the accumulation phase of PM2.5 during the pollution episode (PMAE) in the Yangtze River Delta in China. This paper mainly explores the spatial variations of PMAE and its links to the socioeconomic factors using a geographical detector and simple linear regression. The results indicated that PM2.5 was more likely to accumulate in more developed cities, such as Nanjing and Shanghai. Compared with Cyear, PMAE was more sensitive to socioeconomic impacts. Among the twelve indicators chosen for this study, population density was an especially critical factor that could affect the accumulation of PM2.5 dramatically and accounted for the regional difference. A 1% increase in population density could cause a 0.167% rise in the maximal increment and a 0.214% rise in the daily increase rate of PM2.5. Additionally, industry, energy consumption, and vehicles were also significantly associated with PM2.5 accumulation. These conclusions could serve to remediate the severe PM2.5 pollution in China. PMID:27669272

Crustal P-wave velocity structure from Altyn Tagh to Longmen mountains along the Taiwan-Altay geoscience transect

USGS Publications Warehouse

Wang, Y.-X.; Mooney, W.D.; Han, G.-H.; Yuan, X.-C.; Jiang, M.

2005-01-01

Based upon the seismic experiments along Geoscience Transect from the Altyn Tagh to the Longmen Mountains, the crustal P-wave velocity structure was derived to outline the characteristics of the crustal structure. The section shows a few significant features. The crustal thickness varies dramatically, and is consistent with tectonic settings. The Moho boundary abruptly drops to 73km depth beneath the southern Altyn Tagh from 50km below the Tarim basin, then rises again to about 58km depth beneath the Qaidam basin. Finally, the Moho drops again to about 70km underneath the Songpan-Garze Terrane and rises to 60km near the Longmen Mountains with a step-shape. Further southeast, the crust thins to 52km beneath the Sichuan basin in the southeast of the Longmen Mountains. In the north of the Kunlun fault, a low-velocity zone, which may be a layer of melted rocks due to high temperature and pressure at depth, exists in the the bottom of the middle crust. The two depressions of the Moho correlate with the Qilian and Songpan-Garze terranes, implying that these two mountains have thick roots. According to our results, it is deduced that the thick crust of the northeastern Tibetan Plateau probably is a result of east-west and northwest-southeast crustal shortening since Mesozoic time during the collision between the Asian and Indian plates.

Modeling impacts of sea-level rise, oil price, and management strategy on the costs of sustaining Mississippi delta marshes with hydraulic dredging.

PubMed

Wiegman, Adrian R H; Day, John W; D'Elia, Christopher F; Rutherford, Jeffrey S; Morris, James T; Roy, Eric D; Lane, Robert R; Dismukes, David E; Snyder, Brian F

2018-03-15

Over 25% of Mississippi River delta plain (MRDP) wetlands were lost over the past century. There is currently a major effort to restore the MRDP focused on a 50-year time horizon, a period during which the energy system and climate will change dramatically. We used a calibrated MRDP marsh elevation model to assess the costs of hydraulic dredging to sustain wetlands from 2016 to 2066 and 2016 to 2100 under a range of scenarios for sea level rise, energy price, and management regimes. We developed a subroutine to simulate dredging costs based on the price of crude oil and a project efficiency factor. Crude oil prices were projected using forecasts from global energy models. The costs to sustain marsh between 2016 and 2100 changed from $128,000/ha in the no change scenario to ~$1,010,000/ha in the worst-case scenario for sea level rise and energy price, an ~8-fold increase. Increasing suspended sediment concentrations, which is possible using managed river diversions, raised created marsh lifespan and decreased long term dredging costs. Created marsh lifespan changed nonlinearly with dredging fill elevation and suspended sediment level. Cost effectiveness of marsh creation and nourishment can be optimized by adjusting dredging fill elevation to the local sediment regime. Regardless of management scenario, sustaining the MRDP with hydraulic dredging suffered declining returns on investment due to the convergence of energy and climate trends. Marsh creation will likely become unaffordable in the mid to late 21st century, especially if river sediment diversions are not constructed before 2030. We recommend that environmental managers take into consideration coupled energy and climate scenarios for long-term risk assessments and adjust restoration goals accordingly. Copyright © 2017 Elsevier B.V. All rights reserved.

Charging effects in single InP/GaInP baby dots

NASA Astrophysics Data System (ADS)

Persson, Jonas

2001-03-01

It has recently been demonstrated that the matrix material plays a major role for the physical behavior of self-assembled InP/GaInP quantum dots. As the "intrinsically" n-type GaInP matrix fills the quantum dot with electrons the spectral behavior of the dot dramatically changes. For the larger, fully developed dots, the charging gives rise to several broad lines. With an external bias it is possible to reduce the electron population of the dot. For smaller dots, baby dots, we show the possibility of dramatically changing the appearance of the dot spectrum by a precise tuning of the size of the quantum dot. When the dot is small enough it is uncharged and the spectrum is very similar to other material systems, whereas a slightly larger dot is charged and the number of lines is dramatically increased. We present high spectral resolution photoluminescence measurements of individual InP/GaInP baby-dots and k\\cdotp calculations including direct and exchange interactions.

Probabilistic Projections of Future Sea-Level Change and Their Implications for Flood Risk Management: Insights from the American Climate Prospectus

NASA Astrophysics Data System (ADS)

Kopp, R. E., III; Delgado, M.; Horton, R. M.; Houser, T.; Little, C. M.; Muir-Wood, R.; Oppenheimer, M.; Rasmussen, D. M., Jr.; Strauss, B.; Tebaldi, C.

2014-12-01

Global mean sea level (GMSL) rise projections are insufficient for adaptation planning; local decisions require local projections that characterize risk over a range of timeframes and tolerances. We present a global set of local sea level (LSL) projections to inform decisions on timescales ranging from the coming decades through the 22nd century. We present complete probability distributions, informed by a combination of expert community assessment, expert elicitation, and process modeling [1]. We illustrate the application of this framework by estimating the joint distribution of future sea-level change and coastal flooding, and associated economic costs [1,2]. In much of the world in the current century, differences in median LSL projections are due primarily to varying levels of non-climatic uplift or subsidence. In the 22nd century and in the high-end tails, larger ice sheet contributions, particularly from the Antarctic ice sheet (AIS), contribute significantly to site-to-site differences. Uncertainty in GMSL and most LSL projections is dominated by the uncertain AIS component. Sea-level rise dramatically reshapes flood risk. For example, at the New York City (Battery) tide gauge, our projections indicate a likely (67% probability) 21st century LSL rise under RCP 8.5 of 65--129 cm (1-in-20 chance of exceeding 154 cm). Convolving the distribution of projected sea-level rise with the extreme value distribution of flood return periods indicates that this rise will cause the current 1.80 m `1-in-100 year' flood event to occur an expected nine times over the 21st century -- equivalent to the expected number of `1-in-11 year' floods in the absence of sea-level change. Projected sea-level rise for 2100 under RCP 8.5 would likely place 80-160 billion of current property in New York below the high tide line, with a 1-in-20 chance of losses >190 billion. Even without accounting for potential changes in storms themselves, it would likely increase average annual storm damage by 2.6-5.2 billion (1-in-20 chance of >7 billion). Projected increases in tropical cyclone intensity would further increase damages [2]. References: [1] R. E. Kopp et al. (2014), Earth's Future, doi:10.1002/2014EF000239. [2] T. Houser et al. (2014), American Climate Prospectus, www.climateprospectus.org.

β-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload

PubMed Central

Melchiori, Luca; Gardenghi, Sara; Rivella, Stefano

2010-01-01

β-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of β-globin. The defects involved are extremely heterogeneous and give rise to a large phenotypic spectrum, with patients that are almost asymptomatic to cases in which regular blood transfusions are required to sustain life. As a result of the inefficient synthesis of β-globin, the patients suffer from chronic anemia due to a process called ineffective erythropoiesis (IE). The sequelae of IE lead to extramedullary hematopoiesis (EMH) with massive splenomegaly and dramatic iron overload, which in turn is responsible for many of the secondary pathologies observed in thalassemic patients. The processes are intimately linked such that an ideal therapeutic approach should address all of the complications. Although β-thalassemia is one of the first monogenic diseases to be described and represents a global health problem, only recently has the scientific community started to focus on the real molecular mechanisms that underlie this disease, opening new and exciting therapeutic perspectives for thalassemic patients worldwide. PMID:20508726

The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account.

PubMed

Hünig, Thomas

2016-09-01

Two decades ago, we discovered 'superagonistic' monoclonal antibodies specific for the CD28 molecule which are able to polyclonally activate T cells, in particular regulatory T cells, and are therapeutically active in many rodent models of autoimmunity, inflammation, transplantation, and tissue repair. A phase I trial of the human CD28 superagonist TGN1412 failed in 2006 due to an unexpected cytokine release syndrome, but after it became clear that dose-reduction allows to preferentially address regulatory T cells also in humans, clinical development was resumed under the name TAB08. Here, I recount the story of CD28 superagonist development from a personal perspective with an emphasis on the dramatic events during and after the 2006 phase I trial, the reasons for the failure of preclinical research to warn of the impending cytokine storm, and on the research which allowed resumption of clinical development. © 2016 Federation of European Biochemical Societies.

Evaluating the Role of Small Impoundments in Legacy Sediment Storage

NASA Astrophysics Data System (ADS)

Bain, D. J.; Salant, N.; Green, M. B.; Wreschnig, A. J.; Urbanova, T.

2009-12-01

Recent research highlighting the prevalence of dams built for water power in the mid-1800s has led to suggestions that strategies for managing legacy sediment in the Eastern United States should be re-evaluated. However, the link between reach-scale observations of historic dam sites to processes at the catchment scale have not been examined, nor have the role of other, similar historic changes been evaluated. This presentation will compare dam dynamics, including mill density data and synthetic estimates of beaver populations with sedimentation rates recorded in sediment cores. If low-head dams were a dominant mechanism in sediment storage, we expect to see changes in sedimentation rates with the expatriation of the beaver and the rise and decline of water power. Further, we expect to see spatial variation in these changes as beaver and mill densities and potential sediment yield are spatially heterogeneous. Ultimately, dramatic changes in sediment yield due to land use and hydrological alterations likely drove sedimentation rates; the mechanistic importance of storage likely depends on temporal coincidence.

Changes in bacterial meningitis.

PubMed Central

Carter, P E; Barclay, S M; Galloway, W H; Cole, G F

1990-01-01

In 1964, one of us (WHG) undertook a retrospective study of bacterial meningitis in childhood in the north east of Scotland during the period 1946-61. We have recently carried out a similar review of cases occurring during 1971-86, to compare the incidence, mortality, and bacteriological patterns. During the earlier period 285 cases occurred, a total incidence of 16.9/100,000 children per year. In the later period 274 children were affected, an annual incidence of 17.8/100,000. The overall mortality rate fell dramatically from 11.9% to 1.8%, the latter figure comparing favourably with recent published studies from Scandinavia and the United States. There was a change in the bacteriological profile in the second period with a significant rise in cases due to Haemophilus influenzae at all ages. A fall in cases of meningococcal meningitis was significant in infants under 1 year of age only. Possible reasons for the change in the bacteriological pattern are discussed. PMID:2357086

Visualizing decoupling in nanocrystalline alloys: A FORC-temperature analysis

NASA Astrophysics Data System (ADS)

Rivas, M.; Martínez-García, J. C.; Gorria, P.

2016-02-01

Devitrifying ferromagnetic amorphous precursors in the adequate conditions may give rise to disordered assemblies of densely packed nanocrystals with extraordinary magnetic softness well explained by the exchange coupling among multiple crystallites. Whether the magnetic exchange interaction is produced by direct contact or mediated by the intergranular amorphous matrix has a strong influence on the behaviour of the system above room temperature. Multi-phase amorphous-nanocrystalline systems dramatically harden when approaching the amorphous Curie temperature (TC) due to the hard grains decoupling. The study of the thermally induced decoupling of nanosized crystallites embedded in an amorphous matrix has been performed in this work by the first-order reversal curves (FORCs) analysis. We selected a Fe-rich amorphous alloy with TC = 330 K, in order to follow the evolution of the FORC diagrams obtained below and above such temperature in samples with different percentages of nanocrystalline phase. The existence of up to four regions exhibiting unlike magnetic behaviours is unambiguously determined from the temperature evolution of the FORC.

The curse of wealth – Middle Eastern countries need to address the rapidly rising burden of diabetes

PubMed Central

Klautzer, Lisa; Becker, Joachim; Mattke, Soeren

2014-01-01

The energy boom of the last decade has led to rapidly increasing wealth in the Middle East, particularly in the oil and gas-rich Gulf Cooperation Council (GCC) countries. This exceptional growth in prosperity has brought with it rapid changes in lifestyles that have resulted in a significant rise in chronic disease. In particular the number of people diagnosed with diabetes has increased dramatically and health system capacity has not kept pace. In this article, we summarize the current literature to illustrate the magnitude of the problem, its causes and its impact on health and point to options how to address it. PMID:24757686

Understanding the Recent Increase in Ferritin Levels in United States Dialysis Patients: Potential Impact of Changes in Intravenous Iron and Erythropoiesis-Stimulating Agent Dosing.

PubMed

Karaboyas, Angelo; Zee, Jarcy; Morgenstern, Hal; Nolen, Jacqueline G; Hakim, Raymond; Kalantar-Zadeh, Kamyar; Zager, Philip; Pisoni, Ronald L; Port, Friedrich K; Robinson, Bruce M

2015-10-07

Anemia management changed substantially among dialysis patients in the United States around the time of implementation of the new Centers for Medicare & Medicaid Services bundled payment system and erythropoiesis-stimulating agent (ESA) label change in 2011. Among these, average ferritin levels increased dramatically and have remained high since; this study sought to gain understanding of this sustained rise in ferritin levels. Trends in mean ferritin, hemoglobin, IV iron dose, and ESA dose from 2009 to 2013 were examined in 9735 patients from 91 United States Dialysis Outcomes and Practice Patterns Study facilities. Linear mixed models were used to assess the extent to which intravenous (IV) iron and ESA dose accounted for patients' changes in ferritin over time. Mean ESA dose and hemoglobin levels declined throughout the study. Mean IV iron dose increased from 210 mg/mo in 2009-2010 to a peak of 280 mg/mo in 2011, then declined back to 200 mg/mo and remained stable from 2012 to 2013. Mean ferritin increased from 601 ng/ml in the third quarter of 2009 to 887 ng/ml in the first quarter of 2012; models suggest that higher IV iron dosing was a primary determinant during 2011, but lower ESA doses contributed to the sustained high ferritin levels thereafter. In a subset of 17 facilities that decreased IV iron dose in 2011, mean ferritin rose by 120 ng/ml to 764 ng/ml, which appeared to be primarily due to ESA reduction. Together, changes in IV iron and ESA doses accounted for 46% of the increase in ferritin over the study period. In contrast to expectations, the rise in average IV iron dose did not persist beyond 2011. The sustained rise in ferritin levels in United States dialysis patients after policy changes in 2011, to average levels well in excess of 800 ng/ml, appeared to be partly due to reductions in ESA dosing and not solely IV iron dosing practices. The effect of these changes in ferritin on health outcomes requires further investigation. Copyright © 2015 by the American Society of Nephrology.

Understanding the Recent Increase in Ferritin Levels in United States Dialysis Patients: Potential Impact of Changes in Intravenous Iron and Erythropoiesis-Stimulating Agent Dosing

PubMed Central

Zee, Jarcy; Morgenstern, Hal; Nolen, Jacqueline G.; Hakim, Raymond; Kalantar-Zadeh, Kamyar; Zager, Philip; Pisoni, Ronald L.; Port, Friedrich K.; Robinson, Bruce M.

2015-01-01

Background and objectives Anemia management changed substantially among dialysis patients in the United States around the time of implementation of the new Centers for Medicare & Medicaid Services bundled payment system and erythropoiesis-stimulating agent (ESA) label change in 2011. Among these, average ferritin levels increased dramatically and have remained high since; this study sought to gain understanding of this sustained rise in ferritin levels. Design, setting, participants, & measurements Trends in mean ferritin, hemoglobin, IV iron dose, and ESA dose from 2009 to 2013 were examined in 9735 patients from 91 United States Dialysis Outcomes and Practice Patterns Study facilities. Linear mixed models were used to assess the extent to which intravenous (IV) iron and ESA dose accounted for patients’ changes in ferritin over time. Results Mean ESA dose and hemoglobin levels declined throughout the study. Mean IV iron dose increased from 210 mg/mo in 2009–2010 to a peak of 280 mg/mo in 2011, then declined back to 200 mg/mo and remained stable from 2012 to 2013. Mean ferritin increased from 601 ng/ml in the third quarter of 2009 to 887 ng/ml in the first quarter of 2012; models suggest that higher IV iron dosing was a primary determinant during 2011, but lower ESA doses contributed to the sustained high ferritin levels thereafter. In a subset of 17 facilities that decreased IV iron dose in 2011, mean ferritin rose by 120 ng/ml to 764 ng/ml, which appeared to be primarily due to ESA reduction. Together, changes in IV iron and ESA doses accounted for 46% of the increase in ferritin over the study period. Conclusions In contrast to expectations, the rise in average IV iron dose did not persist beyond 2011. The sustained rise in ferritin levels in United States dialysis patients after policy changes in 2011, to average levels well in excess of 800 ng/ml, appeared to be partly due to reductions in ESA dosing and not solely IV iron dosing practices. The effect of these changes in ferritin on health outcomes requires further investigation. PMID:26286925

Aiding or Dissuading? The Effect of Maintaining Eligibility for Need-Based Financial Aid on Late Stage Persistence and Completion

ERIC Educational Resources Information Center

Mabel, Zachary A.

2016-01-01

The returns to higher education have increased dramatically in recent decades with the rise of the global, knowledge-based economy. Research shows that the college earnings premium has increased more than 10 percent over the last fifteen years and that the returns to college are concentrated among completers. Despite these benefits, many students…

Future Need of Ageing People with an Intellectual Disability in the Republic of Ireland: Lessons Learned from the Literature

ERIC Educational Resources Information Center

Doody, Catriona M.; Markey, Kathleen; Doody, Owen

2013-01-01

People with an intellectual disability are living longer, and the numbers continue to rise. Ireland has and is seeing a dramatic change in the age pro?le of clients and the support services they require. While Ireland had speci?cally trained nurses in intellectual disability, they predominately work in residential settings. This can be seen as…

Cultivating the Socially Competent Body: Bodies and Risk in Swedish Programmes for Social Emotional Learning in Preschools and Schools

ERIC Educational Resources Information Center

Bartholdsson, Åsa; Gustafsson-Lundberg, Johanna; Hultin, Eva

2014-01-01

Social emotional learning (SEL) is common in preschools and schools both in Europe and North America today. Programmes for socio-emotional training and the rise of what is labelled therapeutic education have dramatically increased during the first decade of the millennium. In this article, a manual-based programme used for SEL in a Swedish school…

About Student's Media Use for Learning in Tertiary Education Influence Factors and Structures of Usage Behavior

ERIC Educational Resources Information Center

Grosch, Michael

2014-01-01

The rise of the web 2.0 led to dramatic changes in media usage behavior of students in tertiary education. Services such as Google and Facebook are most accepted amongst students not only in pastime but also for learning. A representative survey was made at Karlsruhe Institute of Technology (KIT). About 1,400 students were asked 150 questions to…

Preparing At-Risk Youth for a Changing World: Revisiting a Person-in-Context Model for Transition to Employment

ERIC Educational Resources Information Center

DeLuca, Christopher; Godden, Lorraine; Hutchinson, Nancy L.; Versnel, Joan

2015-01-01

Background: The current global cohort of youth has been called "a generation at-risk", marked by a dramatic rise in youth who are not in employment, education or training programmes. In 2010, youth were three times as likely as adults to be unemployed, with youth unemployment worsening in 2012 and 2013. Accordingly, there is an urgent…

Automatic for the Borrower: How Repayment Based on Income Can Reduce Loan Defaults and Manage Risk

ERIC Educational Resources Information Center

Baum, Sandy; Carew, Diana; Fraire, Jacob; Jacks, Kay; James, Kevin; Madzelan, Daniel; Miller, Scott E.; Simmons, Barry; Thompson, Jessica

2014-01-01

When borrowers default on a federal student loan, it can have catastrophic consequences. Their credit scores drop dramatically, severely curtailing their ability to afford a home or a car, and even limiting their ability to sign up for utilities. The cost of their loan rises as late fees pile up. Moreover, the federal government can garnish…

Taxonomy for Child Well-Being Indicators: A Framework for the Analysis of the Well-Being of Children

ERIC Educational Resources Information Center

Ben-Arieh, Asher; Frones, Ivar

2011-01-01

Recent years have brought a dramatic rise in the number of efforts to measure and monitor the status of children. Yet, despite numerous efforts and reports with "Child indicators" in the title, the field of social child indication is fragmented and lacking a unifying taxonomy. The more ambitious the analysis and the more elaborate the statistics,…

Dietary fat source alters hepatic gene expression profile and determines the type of live pathology in rats overfed via total eteral nutrtion

USDA-ARS?s Scientific Manuscript database

Non-alcoholic fatty liver disease (NAFLD) is considered a part of the 'metabolic syndrome' associated with obesity and can progress in some patients to chirrosis, loss of liver function and liver cancer. NAFLD is now the most common form of liver injury, and rates are rising dramatically as a result...

76 FR 35104 - Safety Zone; Waterway Closure, Atchafalaya River From Mile Marker 117 (Morgan City Railroad...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-16

... from destruction, loss or injury due to hazards associated with rising flood water. DATES: Effective... destruction, loss or injury due to the hazards associated with rising flood water. Notifications to the marine..., levee system, vessels and tows from the hazards associated with rising flood water on the Atchafalaya...

Assessing Students' Learning Outcomes, Self-Efficacy and Attitudes toward the Integration of Virtual Science Laboratory in General Physics

ERIC Educational Resources Information Center

Ghatty, Sundara L.

2013-01-01

Over the past decade, there has been a dramatic rise in online delivery of higher education in the United States. Recent developments in web technology and access to the internet have led to a vast increase in online courses. For people who work during the day and whose complicated lives prevent them from taking courses on campus, online courses…

Eurabia: Strategic Implications for the United States

DTIC Science & Technology

2010-03-01

display a currently valid OMB control number. 1. REPORT DATE 30 MAR 2010 2. REPORT TYPE 3. DATES COVERED 4. TITLE AND SUBTITLE Eurabia: Strategic...projecting current trends into the future seldom holds true in the face of demographic realities, i.e. nature gets a vote so to speak. These social welfare...portion of the population. Nevertheless, current predictions have it rising dramatically over the coming decades. Most demographers predict that by

The Impact of eBooks on the Reading Motivation and Reading Skills of Children and Young People: A Rapid Literature Review

ERIC Educational Resources Information Center

Picton, Irene

2014-01-01

While ebooks have been around for many years, recent rapid improvements in the versatility and affordability of e-readers and tablets, along with increased access to broadband internet, have lead to a dramatic rise in household ownership of these devices. Between 2012 and 2013, the proportion of children responding to the National Literacy Trust's…

Toward Critical Data-Scientific Literacy: An Intersectional Analysis of the Development of Student Identities in An Introduction to Data Science Course

ERIC Educational Resources Information Center

Olivares Pasillas, Maria Concepción

2017-01-01

The national imperative to increase the presence of women and people of color in science, technology, engineering, and mathematics (STEM) coupled with the growing presence of Latinos in the United States has led to the dramatic rise of programs and initiatives aimed at improving access to and equity in STEM careers and education for Latino youth.…

Self induced gratings in ternary SiO2:SnO2:Na2O bulk glasses by UV light seeding.

PubMed

Lancry, M; Douay, M; Niay, P; Beclin, F; Menke, Y; Milanese, D; Ferraris, M; Poumellec, B

2005-09-05

The diffraction efficiency of gratings written in ternary SnO2:SiO2:Na2O bulk glasses rises dramatically with time after the occultation of the cw 244nm light used to write the thick hologram. This self-induced behavior lasts for several hours and ultimately leads to refractive index changes as high as 3 10-3.

Increased incidence of syphilis in Tennessee during the 1980s: challenges for a new decade.

PubMed

Quinn, R W; Federspiel, C F; Lefkowitz, L B; Keller, R

1992-08-01

Although recent increases in the incidence of syphilis are well known to public health officials, the general medical community is less well informed regarding the dramatic rise in cases. We present trend data from Nashville and Tennessee over the past decade. These statistics emphasize specific factors, such as drug abuse, that contribute to new difficulties in controlling this sexually transmitted disease.

Constructive systems, load-bearing and enclosing structures of high-rise buildings

NASA Astrophysics Data System (ADS)

Anatol'evna Korol', Elena; Olegovna Kustikova, Yuliya

2018-03-01

As the height of the building increases, loads on load-carrying structures increase dramatically, and as a result of the development of high-rise construction, several structural systems of such buildings have been developed: frame, frame-frame, cross-wall, barrel, box-type, box-to-wall ("pipe in pipe", "Trumpet in the farm"), etc. In turn, the barrel systems have their own versions: cantilever support of the ceilings on the trunk, suspension of the outer part of the overlap to the upper carrying console "hanging house" or its support by means of the walls on the lower bearing cantilever, intermediate position of the supporting cantilevers in height to the floor, from a part of floors. The object of the study are the structural solutions of high-rise buildings. The subject of the study is the layout of structural schemes of high-rise buildings, taking into account the main parameters - altitude (height), natural climatic conditions of construction, materials of structural elements and their physical and mechanical characteristics. The purpose of the study is to identify the features and systematization of structural systems of high-rise buildings and the corresponding structural elements. The results of the research make it possible, at the stage of making design decisions, to establish rational parameters for the correspondence between the structural systems of high-rise buildings and their individual elements.

A meeting of the waters: interdisciplinary challenges and opportunities in tidal rivers

USGS Publications Warehouse

Ensign, Scott H.; Noe, Gregory B.; Hupp, Cliff R.; Fagherazzi, Sergio

2012-01-01

At the interface of estuarine tides and freshwater rivers lie wetland and aquatic ecosystems, which experience dramatic effects of sea level rise. There, nontidal channels and riparian floodplains are transforming into tidal ecosystems, and tidal freshwater ecosystems are receiving increasing salinity. These river-floodplain systems have both fluvial characteristics, including meandering channels and expansive floodplain forests, and estuarine characteristics, including tides and intertidal wetlands [see Barendregt et al., 2009; Conner et al., 2007, and references therein]. Because tidal rivers lie at the disciplinary divide between fluvial and estuarine science, a knowledge gap has developed in scientists' understanding of the geomorphic and biogeochemical response of these environments to sea level rise, climate change, and anthropogenically driven variations in watershed exports.

76 FR 36314 - Safety Zone; Mile Marker 98.5 West of Harvey Lock Gulf Intracoastal Waterway to Mile Marker 108.5...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

..., levee system, vessels and tows from destruction, loss or injury due to hazards associated with rising... the general public, levee system, vessels and tows from the hazards associated with rising flood water... system, vessels and tows from destruction, loss or injury due to the hazards associated with rising flood...

Progress toward achieving the national 1990 objectives for sexually transmitted diseases.

PubMed

1987-04-03

A summary evaluation of the status of 5 sexually transmitted disease (STD) goals is presented by the U.S. Public Health Service. 1st, gonorrhea cases, after a rapid rise in the early 1970s, have been steadily declining on the whole. Female cases, however, have been increasing, and resistant strains have spread dramatically. Thus it seems the goal of 280 cases per 100,000 by 1990 will not be met. 2nd, the pelvic inflammatory disease rate is declining toward the goal, even though Chlamydia infections remain a problem. 3rd, the incidence of syphilis, especially in males, is approaching the target of 7/100,000. Congenital syphilis is rising, due both to emphasis on reporting and to a real increase. 4th, the goal of effective diagnosis and treatment of STD by 95% of clinicians is being approached with postgraduate courses and medical school curricula, but this end is probably too ambitious. 5th, all junior and senior high school students should be receiving accurate education about STD. No information on these efforts is available. After these goals were in place, the STD burden has increased phenomenally because of the appearance of AIDS, the maturation of the baby boom generation, and the realization that over 50 different diseases, 13 million cases and 7000 deaths occur annually, excluding AIDS. The cost of treating pelvic inflammatory disease alone is estimated at $2.6 billion annually. Primary prevention is the only feasible priority.

Climate Adaptation and Policy-Induced Inflation of Coastal Property Value

PubMed Central

McNamara, Dylan E.; Gopalakrishnan, Sathya; Smith, Martin D.; Murray, A. Brad

2015-01-01

Human population density in the coastal zone and potential impacts of climate change underscore a growing conflict between coastal development and an encroaching shoreline. Rising sea-levels and increased storminess threaten to accelerate coastal erosion, while growing demand for coastal real estate encourages more spending to hold back the sea in spite of the shrinking federal budget for beach nourishment. As climatic drivers and federal policies for beach nourishment change, the evolution of coastline mitigation and property values is uncertain. We develop an empirically grounded, stochastic dynamic model coupling coastal property markets and shoreline evolution, including beach nourishment, and show that a large share of coastal property value reflects capitalized erosion control. The model is parameterized for coastal properties and physical forcing in North Carolina, U.S.A. and we conduct sensitivity analyses using property values spanning a wide range of sandy coastlines along the U.S. East Coast. The model shows that a sudden removal of federal nourishment subsidies, as has been proposed, could trigger a dramatic downward adjustment in coastal real estate, analogous to the bursting of a bubble. We find that the policy-induced inflation of property value grows with increased erosion from sea level rise or increased storminess, but the effect of background erosion is larger due to human behavioral feedbacks. Our results suggest that if nourishment is not a long-run strategy to manage eroding coastlines, a gradual removal is more likely to smooth the transition to more climate-resilient coastal communities. PMID:25806944

Climate adaptation and policy-induced inflation of coastal property value.

PubMed

McNamara, Dylan E; Gopalakrishnan, Sathya; Smith, Martin D; Murray, A Brad

2015-01-01

Human population density in the coastal zone and potential impacts of climate change underscore a growing conflict between coastal development and an encroaching shoreline. Rising sea-levels and increased storminess threaten to accelerate coastal erosion, while growing demand for coastal real estate encourages more spending to hold back the sea in spite of the shrinking federal budget for beach nourishment. As climatic drivers and federal policies for beach nourishment change, the evolution of coastline mitigation and property values is uncertain. We develop an empirically grounded, stochastic dynamic model coupling coastal property markets and shoreline evolution, including beach nourishment, and show that a large share of coastal property value reflects capitalized erosion control. The model is parameterized for coastal properties and physical forcing in North Carolina, U.S.A. and we conduct sensitivity analyses using property values spanning a wide range of sandy coastlines along the U.S. East Coast. The model shows that a sudden removal of federal nourishment subsidies, as has been proposed, could trigger a dramatic downward adjustment in coastal real estate, analogous to the bursting of a bubble. We find that the policy-induced inflation of property value grows with increased erosion from sea level rise or increased storminess, but the effect of background erosion is larger due to human behavioral feedbacks. Our results suggest that if nourishment is not a long-run strategy to manage eroding coastlines, a gradual removal is more likely to smooth the transition to more climate-resilient coastal communities.

Can riparian vegetation shade mitigate the expected rise in stream temperatures due to climate change during heat waves in a human-impacted pre-alpine river?

NASA Astrophysics Data System (ADS)

Trimmel, Heidelinde; Weihs, Philipp; Leidinger, David; Formayer, Herbert; Kalny, Gerda; Melcher, Andreas

2018-01-01

Global warming has already affected European rivers and their aquatic biota, and climate models predict an increase of temperature in central Europe over all seasons. We simulated the influence of expected changes in heat wave intensity during the 21st century on water temperatures of a heavily impacted pre-alpine Austrian river and analysed future mitigating effects of riparian vegetation shade on radiant and turbulent energy fluxes using the deterministic Heat Source model. Modelled stream water temperature increased less than 1.5 °C within the first half of the century. Until 2100, a more significant increase of around 3 °C in minimum, maximum and mean stream temperatures was predicted for a 20-year return period heat event. The result showed clearly that in a highly altered river system riparian vegetation was not able to fully mitigate the predicted temperature rise caused by climate change but would be able to reduce water temperature by 1 to 2 °C. The removal of riparian vegetation amplified stream temperature increases. Maximum stream temperatures could increase by more than 4 °C even in annual heat events. Such a dramatic water temperature shift of some degrees, especially in summer, would indicate a total shift of aquatic biodiversity. The results demonstrate that effective river restoration and mitigation require re-establishing riparian vegetation and emphasize the importance of land-water interfaces and their ecological functioning in aquatic environments.

Is frictional heating needed to cause dramatic weakening of nanoparticle gouge during seismic slip? Insights from friction experiments with variable thermal evolutions

NASA Astrophysics Data System (ADS)

Yao, Lu; Ma, Shengli; Niemeijer, André R.; Shimamoto, Toshihiko; Platt, John D.

2016-07-01

To examine whether faults can be lubricated by preexisting and newly formed nanoparticles, we perform high-velocity friction experiments on periclase (MgO) nanoparticles and on bare surfaces of Carrara marble cylinders/slices, respectively. Variable temperature conditions were simulated by using host blocks of different thermal conductivities. When temperature rises are relatively low, we observe high friction in nano-MgO tests and unexpected slip strengthening following initial weakening in marble slice tests, suggesting that the dominant weakening mechanisms are of thermal origin. Solely the rolling of nanoparticles without significant temperature rise is insufficient to cause dynamic fault weakening. For nano-MgO experiments, comprehensive investigations suggest that flash heating is the most likely weakening mechanism. In marble experiments, flash heating controls the unique evolutions of friction, and the competition between bulk temperature rise and wear-induced changes of asperity contact numbers seems to strongly affect the efficiency of flash heating.

Seasonally active frost-dust avalanches on a north polar scarp of Mars captured by HiRISE

USGS Publications Warehouse

Russell, P.; Thomas, N.; Byrne, S.; Herkenhoff, K.; Fishbaugh, K.; Bridges, N.; Okubo, C.; Milazzo, M.; Daubar, I.; Hansen, C.; McEwen, A.

2008-01-01

North-polar temporal monitoring by the High Resolution Imaging Science Experiment (HiRISE) orbiting Mars has discovered new, dramatic examples that Mars1 CO2-dominated seasonal volatile cycle is not limited to quiet deposition and sublimation of frost. In early northern martian spring, 2008, HiRISE captured several cases of CO2 frost and dust cascading down a steep, polar scarp in discrete clouds. Analysis of morphology and process reveals these events to be similar to terrestrial powder avalanches, sluffs, and falls of loose, dry snow. Potential material sources and initiating mechanisms are discussed in the context of the Martian polar spring environment and of additional, active, aeolian processes observed on the plateau above the scarp. The scarp events are identified as a trigger for mass wasting of bright, fractured layers within the basal unit, and may indirectly influence the retreat rate of steep polar scarps in competing ways. Copyright 2008 by the American Geophysical Union.

Northwest African Continental Margin: History of sediment accumulation, landslide deposits, and hiatuses as revealed by drilling the Madeira Abyssal Plain

NASA Astrophysics Data System (ADS)

Weaver, P. P. E.

2003-03-01

ODP drill sites in the Madeira Abyssal Plain reveal sequences of organic-rich turbidites derived from the northwest African margin, in which each turbidite has a volume of tens to hundreds of cubic kilometers. The frequency of turbidite emplacement has been combined with core and seismic data to show the volume of redeposited sediment. The basin began to fill about 22 Ma with numerous small turbidites, up to 100 per million years, each with volumes of a few cubic kilometers. The total volume of turbidites deposited increased between 16 and 11 Ma, as did their individual volumes, and then declined to 7 Ma. At 7 Ma, there was a dramatic increase in the amount of turbidite input to 768 km3/Myr and a rise in the average volume of each unit to 59 km3. These high values have been maintained to the present day. The variations in the amount of redeposited sediment most likely reflect the rates of sedimentation on the northwest African margin since high sedimentation leads to oversteepening of the slopes and eventual mass wasting. The dramatic changes at about 7 Ma may be due to a large increase in upwelling off northwest Africa caused by circulation changes associated with increased glaciation of the poles. Up to 20% of sediment may be remobilized by landslides, with each event leaving a hiatus. Each of these hiatuses extends over an average area of ˜4800 km2 and represents removal of sediment layers several tens of meters thick and of several hundred thousand years duration.

Why Methane Increasing in the Atmosphere is Pushing us Towards New Analytical Approaches for Stable Isotope Ratios

NASA Astrophysics Data System (ADS)

White, J. W. C.; Michel, S. E.; Vaughn, B. H.; Miller, J. B.; Masarie, K. A.; Dlugokencky, E. J.; Sherwood, O.; Tans, P. P.

2015-12-01

Methane is increasing again in the atmosphere after nearly a decade of stable concentrations. As methane has risen by 2.5 times since the beginning of the industrial era, such a rise in concentrations is not surprising. Carbon isotopes, however, make it clear that the recent rise is not simply a resumption of the dramatic rise in the 1900s, but that other causes are at play, and that multiple fluxes may be interacting to yield the observed rise. At the same time, cautious attention is focused on the Arctic, where vast stores of carbon are poised for release as frozen soils melt, and some of that carbon will be released as methane. These realities make it imperative that we improve our monitoring of methane and methane isotopes in the atmosphere. This talk will address the issues that we face in meeting this challenge in the NOAA Global Greenhouse Gas Reference Network, including targets for precision and accuracy needed to calculate regional and global fluxes, technological advances in analytical equipment, maintaining standards, ensuring adequate monitoring sites and meeting all of these needs in an era of funding cuts and uncertainty for environmental monitoring.

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.

PubMed

Ward, Jeanine; Kanchagar, Chitra; Veksler-Lublinsky, Isana; Lee, Rosalind C; McGill, Mitchell R; Jaeschke, Hartmut; Curry, Steven C; Ambros, Victor R

2014-08-19

We have identified, by quantitative real-time PCR, hundreds of miRNAs that are dramatically elevated in the plasma or serum of acetaminophen (APAP) overdose patients. Most of these circulating microRNAs decrease toward normal levels during treatment with N-acetyl cysteine (NAC). We identified a set of 11 miRNAs whose profiles and dynamics in the circulation during NAC treatment can discriminate APAP hepatotoxicity from ischemic hepatitis. The elevation of certain miRNAs can precede the dramatic rise in the standard biomarker, alanine aminotransferase (ALT), and these miRNAs also respond more rapidly than ALT to successful treatment. Our results suggest that miRNAs can serve as sensitive diagnostic and prognostic clinical tools for severe liver injury and could be useful for monitoring drug-induced liver injury during drug discovery.

Influence of pulse repetition rate on percussion drilling of Ti-based alloy by picosecond laser pulses

NASA Astrophysics Data System (ADS)

Kononenko, Taras V.; Freitag, Christian; Sovyk, Dmitry N.; Lukhter, Alexander B.; Skvortsov, Konstantin V.; Konov, Vitaly I.

2018-04-01

Percussion drilling of a Ti-based alloy with 8 ps laser pulses was investigated with emphasis on the influence of the pulse repetition rate (1-300 kHz) on the drilling process. Heat accumulation is found to be responsible for simultaneous significant rise of the average drilling rate, the occurrence of a rim around the hole entrance, as well as noticeable surface oxidation. This can be observed as soon as the repetition rate exceeds a certain critical value, which depends on the pulse energy applied. Dramatic rise of the recast layer thickness inside the growing hole was revealed for the limited range of the repetition rates around the lower boundary of the heat accumulation regime. Possible origins of this phenomenon are discussed.

Possible relation of water structural relaxation to water anomalies

PubMed Central

Mallamace, Francesco; Corsaro, Carmelo; Stanley, H. Eugene

2013-01-01

The anomalous behavior of thermodynamic response functions is an unsolved problem in the physics of water. The mechanism that gives rise to the dramatic indefinite increase at low temperature in the heat capacity, the compressibility, and the coefficient of thermal expansion, is unknown. We explore this problem by analyzing both new and existing experimental data on the power spectrum S(Q, ω) of bulk and confined water at ambient pressure. When decreasing the temperature, we find that the liquid undergoes a structural transformation coinciding with the onset of an extended hydrogen bond network. This network onset seems to give rise to the marked viscoelastic behavior, consistent with the interesting possibility that the sound velocity and response functions of water depend upon both the frequency and wave vector. PMID:23483053

Decomposing Trends in Inequality in Earnings into Forecastable and Uncertain Components

PubMed Central

Cunha, Flavio; Heckman, James

2015-01-01

A substantial empirical literature documents the rise in wage inequality in the American economy. It is silent on whether the increase in inequality is due to components of earnings that are predictable by agents or whether it is due to greater uncertainty facing them. These two sources of variability have different consequences for both aggregate and individual welfare. Using data on two cohorts of American males we find that a large component of the rise in inequality for less skilled workers is due to uncertainty. For skilled workers, the rise is less pronounced. PMID:27087741

Assessing hazards along our Nation's coasts

USGS Publications Warehouse

Hapke, Cheryl J.; Brenner, Owen; Henderson, Rachel E.; Reynolds, B.J.

2013-01-01

Coastal areas are essential to the economic, cultural, and environmental health of the Nation, yet by nature coastal areas are constantly changing due to a variety of events and processes. Extreme storms can cause dramatic changes to our shorelines in a matter of hours, while sea-level rise can profoundly alter coastal environments over decades. These changes can have a devastating impact on coastal communities, such as the loss of homes built on retreating sea cliffs or protective dunes eroded by storm waves. Sometimes, however, the changes can be positive, such as new habitat created by storm deposits. The U.S. Geological Survey (USGS) is meeting the need for scientific understanding of how our coasts respond to different hazards with continued assessments of current and future changes along U.S. coastlines. Through the National Assessment of Coastal Change Hazards (NACCH), the USGS carries out the unique task of quantifying coastal change hazards along open-ocean coasts in the United States and its territories. Residents of coastal communities, emergency managers, and other stakeholders can use science-based data, tools, models, and other products to improve planning and enhance resilience.

[Clinical nursing manpower: development and future prospects].

PubMed

Lin, Chiou-Fen; Kao, Ching-Chiu

2014-04-01

The significant changes in nursing manpower utilization in Taiwan over the past two decades are due in large part to the implementation of the National Health Insurance program and the rising need for long-term care. The changes have impacted clinical nursing manpower utilization in two important ways. Firstly, there has been a substantial increase in overall demand for nursing manpower. In particular, the need for clinical nurses has nearly quadrupled during this time period. Secondly, the level of difficulty involved in patient care has risen dramatically, with factors including increased disease severity and increased care quality expectations, among others. These changes, coupled with demands on nursing manpower imposed from other sectors, underpin and further exacerbate the problem of nursing manpower shortages throughout the healthcare system. To raise the quality of the nursing work environment, the Ministry of Health and Welfare (MOHW) brought together Taiwan's key professional nursing organizations to promote 10 care-reform strategies, establish the nursing-aid manpower system, and create the nursing classification system as an approach to effectively attract nurses to take positions in the medical system.

Seasonal dynamics and spatial distribution pattern of Parapoynx crisonalis (Lepidoptera: Crambidae) on water chestnuts.

PubMed

Li, Ni; Chen, Qi; Zhu, Jie; Wang, Xing; Huang, Jian-Bin; Huang, Guo-Hua

2017-01-01

Parapoynx crisonalis (Walker, 1859) (Lepidoptera: Crambidae) is a major pest of aquatic vegetables and aquatic landscape plants. It has been responsible for causing considerable economic damage to water chestnut (Trapa natans) plants. In the Changsha vicinity of China, P. crisonalis has five generations a year. Populations of P. crisonalis were relatively low in April and began to rapidly rise at the beginning of May. At the end of July and early August, the population dropped dramatically. A rebound occurred at the end of August and early September, which was referred to as the second population peak. From then, until early November, the P. crisonalis population steadily diminished in preparation for overwintering. The primary factors influencing the seasonal dynamics of P. crisonalis were the climatic conditions, especially the temperature, and secondarily precipitation. Between May and October, the P. crisonalis adults were evenly distributed in the pond. In May and June, the eggs of P. crisonalis were present in an aggregate distribution, due to the effects of environmental heterogeneity. In July and August, however, they were found to be in a uniform distribution.

Seasonal dynamics and spatial distribution pattern of Parapoynx crisonalis (Lepidoptera: Crambidae) on water chestnuts

PubMed Central

Zhu, Jie; Wang, Xing; Huang, Jian-Bin; Huang, Guo-Hua

2017-01-01

Parapoynx crisonalis (Walker, 1859) (Lepidoptera: Crambidae) is a major pest of aquatic vegetables and aquatic landscape plants. It has been responsible for causing considerable economic damage to water chestnut (Trapa natans) plants. In the Changsha vicinity of China, P. crisonalis has five generations a year. Populations of P. crisonalis were relatively low in April and began to rapidly rise at the beginning of May. At the end of July and early August, the population dropped dramatically. A rebound occurred at the end of August and early September, which was referred to as the second population peak. From then, until early November, the P. crisonalis population steadily diminished in preparation for overwintering. The primary factors influencing the seasonal dynamics of P. crisonalis were the climatic conditions, especially the temperature, and secondarily precipitation. Between May and October, the P. crisonalis adults were evenly distributed in the pond. In May and June, the eggs of P. crisonalis were present in an aggregate distribution, due to the effects of environmental heterogeneity. In July and August, however, they were found to be in a uniform distribution. PMID:28863164

Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

PubMed

Hondares, Elayne; Rosell, Meritxell; Gonzalez, Frank J; Giralt, Marta; Iglesias, Roser; Villarroya, Francesc

2010-03-03

Plasma FGF21 levels and hepatic FGF21 gene expression increase dramatically after birth in mice. This induction is initiated by suckling, requires lipid intake, is impaired in PPARalpha null neonates, and is mimicked by treatment with the PPARalpha activator, Wy14,643. Neonates exhibit reduced FGF21 expression in response to fasting, in contrast to the upregulation occurring in adults. Changes in FGF21 expression due to suckling or nutritional manipulations were associated with circulating free fatty acid and ketone body levels. We mimicked the FGF21 postnatal rise by injecting FGF21 into fasting neonates, and found that this enhanced the expression of genes involved in thermogenesis within brown fat, and increased body temperature. Brown adipocytes treated with FGF21 exhibited increased expression of thermogenic genes, higher total and uncoupled respiration, and enhanced glucose oxidation. We propose that the induction of FGF21 production by the liver mediates direct activation of brown fat thermogenesis during the fetal-to-neonatal transition. 2010 Elsevier Inc. All rights reserved.

The Effect of Eating Style and Portion Size on the Accuracy of Dietary Self-Monitoring Among Normal Weight and Overweight Women

DTIC Science & Technology

2007-07-23

or more days) were at 4.5 times greater risk of obesity compared to those who regularly consumed breakfast . Although total energy intake by meal was...promotes continuing weight loss: Preliminary results of a cognitive-behavioral decision-based treatment for obesity . Journal of Consulting...Sbrocco, Ph.D. Associate Professor Department of Medical and Clinical Psychology Given the dramatic rise in obesity and related disorders, it is

Drug-induced iatrogenic intraparenchymal hemorrhage.

PubMed

Lapsiwala, Samir; Moftakhar, Roham; Badie, Behnam

2002-07-01

Intracerebral hemorrhage is bleeding into the brain parenchyma with possible extension into the ventricles and subarachnoid space. Each year, approximately 37,000 to 52,400 people suffer from intraparenchymal hemorrhage (IPH) in the United States. This rate is expected to rise dramatically in the next few decades as a result of the increasing age of the population and a change in racial demographics. IPH accounts for 8% to 13% of all stroke cases and is associated with the highest mortality rate.

Saving our backs: safe patient handling and mobility for home care.

PubMed

Beauvais, Audrey; Frost, Lenore

2014-01-01

Predicted work-related injuries for nurses and home healthcare workers are on the rise given the many risk factors in the home environment and the escalating demands for home healthcare workers in the United States. Fortunately, safe patient handling and mobility programs can dramatically decrease injuries. Despite strides being made to promote safe patient handling and mobility programs in acute care, more can be done to establish such initiatives in the home care setting.

Skirt clouds associated with the soufriere eruption of 17 april 1979.

PubMed

Barr, S

1982-06-04

A fortuitous and dramatic photograph of the Soufriere eruption column of 17 April 1979 displays a series of highly structured skirt clouds. The gentle distortion of thin, quasi-horizontal layers of moist air has been documented in meteorological situations. It is proposed that at St. Vincent subhorizontal layers of moist air were intensely deformed by the rapidly rising eruption column and were carried to higher altitudes, where they condensed to form the skirt clouds.

Beyond the Wall: Chinese Far Seas Operations (China Maritime Study, Number 13)

DTIC Science & Technology

2015-05-01

the most significant resource is energy. Asian oil consumption has risen far more quickly than that of any other region in the world, growing from...17 percent of global daily consumption in 1983 to 31 percent by 2009. China in particular has seen its dependence on foreign oil rise dramatically...since it became a net importer of oil in 1993. Another emerging economy, India, has also experienced fast growth in consumption of foreign oil . The

Acute effects of a glucose energy drink on behavioral control.

PubMed

Howard, Meagan A; Marczinski, Cecile A

2010-12-01

There has been a dramatic rise in the consumption of glucose energy drinks (e.g., Amp, Monster, and Red Bull) in the past decade, particularly among high school and college students. However, little laboratory research has examined the acute objective and subjective effects of energy drinks. The purpose of this study was to investigate the acute effects of a glucose energy drink (Red Bull) on cognitive functioning. Participants (N = 80) were randomly assigned to one of five conditions: 1.8 ml/kg energy drink, 3.6 ml/kg energy drink, 5.4 ml/kg energy drink, placebo beverage, or no drink. Participants completed a well-validated behavioral control task (the cued go/no-go task) and subjective measures of stimulation, sedation, and mental fatigue both before and 30 minutes following beverage administration. The results indicated that compared with the placebo and no drink conditions, the energy drink doses decreased reaction times on the behavioral control task, increased subjective ratings of stimulation and decreased ratings of mental fatigue. Greatest improvements in reaction times and subjective measures were observed with the lowest dose and improvements diminished as the dose increased. The findings suggest that energy drink consumption can improve cognitive performance on a behavioral control task, potentially explaining the dramatic rise in popularity of these controversial new beverages. PsycINFO Database Record (c) 2010 APA, all rights reserved.

Changes in CaCO3 Burial Trump the Biological Pump

NASA Astrophysics Data System (ADS)

Toggweiler, J.; Dunne, J. P.

2008-12-01

The dramatic increases in atmospheric CO2 at the ends of ice ages are usually attributed to a one-two punch coming from the ocean. First, a weakened biological pump vents organically cycled CO2 from the deep ocean via changes in the ventilation of the deep ocean around Antarctica. The initial CO2 increase is then augmented by an enhancement of CaCO3 burial due to a process called CaCO3 compensation (after Broecker, W. S and T.-H. Peng, Global Biogeochem. Cycles, 1, 15-29, 1987). Here, we argue that the importance of the biological pump has been exaggerated. The main effect comes from circulation-induced changes in the burial of CaCO3. As shown in a recent paper by Andreas Schmittner and co-authors (Schmittner, A., E. Brook and J. Ahn, Impact of the ocean's overturning circulation on atmospheric CO2, in Ocean Circulation: Mechanisms and Impacts, Geophys. Monogr. 173, A. Schmittner, J. Chiang, and S. Hemming, eds., pp. 209-246, AGU, 2007) changes in the ventilation of the deep ocean around Antarctica gave rise to 20-30 ppm increases in atmospheric CO2 every 5,000-7,000 years during isotope stages 3 and 4 (30,000 to 70,000 years ago). None of these venting events gave rise to a compensation response. Meanwhile, Jaccard et al. (Science, 308, 1003-1006, 2005) show that all the big CO2 increases during terminations through stage 11 were accompanied by huge increases in CaCO3 burial. This suggests that the enhanced burial of CaCO3 is obligatory rather than compensatory with respect to the dramatic CO2 increases. Broecker and Peng's compensation idea is based on an assumption that the rain of CaCO3 to the sea floor is the same everywhere. More specifically, it assumes that there is no spatial correlation between the production of CaCO3 at the surface and the burial on the sea floor. We find instead that the production and burial of CaCO3 tend to be co-located in regional "hot spots" and that burial in the hot spots balances the input of Ca++ and HCO3- ions in rivers. The hot spots can also move from place to place in response to changes in circulation. The main hot spots today are the eastern Atlantic and southern Indian; the main hot spot during the last glacial was the equatorial Pacific. Renewed deep-water formation in the Atlantic at the end of the last ice age shifted the locus of CaCO3 burial back to the Atlantic and southern Indian and led to a huge drawdown in global alkalinity, which is ongoing today and accounts for most of the deglacial rise in atmospheric CO2.

Many atolls may be uninhabitable within decades due to climate change

USGS Publications Warehouse

Storlazzi, Curt; Elias, Edwin P.L.; Berkowitz, Paul

2015-01-01

Observations show global sea level is rising due to climate change, with the highest rates in the tropical Pacific Ocean where many of the world’s low-lying atolls are located. Sea-level rise is particularly critical for low-lying carbonate reef-lined atoll islands; these islands have limited land and water available for human habitation, water and food sources, and ecosystems that are vulnerable to inundation from sea-level rise. Here we demonstrate that sea-level rise will result in larger waves and higher wave-driven water levels along atoll islands’ shorelines than at present. Numerical model results reveal waves will synergistically interact with sea-level rise, causing twice as much land forecast to be flooded for a given value of sea-level rise than currently predicted by current models that do not take wave-driven water levels into account. Atolls with islands close to the shallow reef crest are more likely to be subjected to greater wave-induced run-up and flooding due to sea-level rise than those with deeper reef crests farther from the islands’ shorelines. It appears that many atoll islands will be flooded annually, salinizing the limited freshwater resources and thus likely forcing inhabitants to abandon their islands in decades, not centuries, as previously thought.

Lake-level history of Lake Michigan for the past 12,000 years: the record from deep lacustrine sediments

USGS Publications Warehouse

Colman, Steven M.; Forester, Richard M.; Reynolds, Richard L.; Sweetkind, Donald S.; King, John W.; Gangemi, Paul; Jones, Glenn A.; Keigwin, Loyd D.; Foster, David S.

1994-01-01

Collection and analysis of an extensive set of seismic-reflection profiles and cores from southern Lake Michigan have provided new data that document the history of the lake basin for the past 12,000 years. Analyses of the seismic data, together with radiocarbon dating, magnetic, sedimentologic, isotopic, and paleontologic studies of core samples, have allowed us to reconstruct lake-level changes during this recent part of the lake's history.The post-glacial history of lake-level changes in the Lake Michigan basin begins about 11.2 ka with the fall from the high Calumet level, caused by the retreat of the Two Rivers glacier, which had blocked the northern outlet of the lake. This lake-level fall was temporarily reversed by a major influx of water from glacial Lake Agassiz (about 10.6 ka), during which deposition of the distinctive gray Wilmette Bed of the Lake Michigan Formation interrupted deposition of red glaciolacustrine sediment. Lake level then continued to fall, culminating in the opening of the North Bay outlet at about 10.3 ka. During the resulting Chippewa low phase, lake level was about 80 m lower than it is today in the southern basin of Lake Michigan.The rise of the early Holocene lake level, controlled primarily by isostatic rebound of the North Bay outlet, resulted in a prominent, planar, transgressive unconformity that eroded most of the shoreline features below present lake level. Superimposed on this overall rise in lake level, a second influx of water from Lake Agassiz temporarily raised lake levels an unknown amount about 9.1 ka. At about 7 ka, lake level may have fallen below the level of the outlet because of sharply drier climate. Sometime between 6 and 5 ka, the character of the lake changed dramatically, probably due mostly to climatic causes, becoming highly undersaturated with respect to calcium carbonate and returning primary control of lake level to the isostatically rising North Bay outlet. Post-Nipissing (about 5 ka) lake level has fallen about 6 m due to erosion of the Port Huron outlet, a trend around which occurred relatively small (± ∼2 m), short-term fluctuations controlled mainly by climatic changes. These cyclic fluctuations are reflected in the sed-imentological and sediment-magnetic properties of the sediments.

Evidence of exceptional oyster-reef resilience to fluctuations in sea level.

PubMed

Ridge, Justin T; Rodriguez, Antonio B; Fodrie, F Joel

2017-12-01

Ecosystems at the land-sea interface are vulnerable to rising sea level. Intertidal habitats must maintain their surface elevations with respect to sea level to persist via vertical growth or landward retreat, but projected rates of sea-level rise may exceed the accretion rates of many biogenic habitats. While considerable attention is focused on climate change over centennial timescales, relative sea level also fluctuates dramatically (10-30 cm) over month-to-year timescales due to interacting oceanic and atmospheric processes. To assess the response of oyster-reef ( Crassostrea virginica ) growth to interannual variations in mean sea level (MSL) and improve long-term forecasts of reef response to rising seas, we monitored the morphology of constructed and natural intertidal reefs over 5 years using terrestrial lidar. Timing of reef scans created distinct periods of high and low relative water level for decade-old reefs ( n  = 3) constructed in 1997 and 2000, young reefs ( n  = 11) constructed in 2011 and one natural reef (approximately 100 years old). Changes in surface elevation were related to MSL trends. Decade-old reefs achieved 2 cm/year growth, which occurred along higher elevations when MSL increased. Young reefs experienced peak growth (6.7 cm/year) at a lower elevation that coincided with a drop in MSL. The natural reef exhibited considerable loss during the low MSL of the first time step but grew substantially during higher MSL through the second time step, with growth peaking (4.3 cm/year) at MSL, reoccupying the elevations previously lost. Oyster reefs appear to be in dynamic equilibrium with short-term (month-to-year) fluctuations in sea level, evidencing notable resilience to future changes to sea level that surpasses other coastal biogenic habitat types. These growth patterns support the presence of a previously defined optimal growth zone that shifts correspondingly with changes in MSL, which can help guide oyster-reef conservation and restoration.

Environmental and Ecological Effects of Climate Change on Venomous Marine and Amphibious Species in the Wilderness.

PubMed

Needleman, Robert K; Neylan, Isabelle P; Erickson, Timothy B

2018-06-25

Recent analyses of data show a warming trend in global average air and sea surface ocean temperatures. The atmosphere and ocean have warmed, the amounts of snow and ice have diminished, the sea level has risen, and the concentrations of greenhouse gases have increased. This article will focus on climate change and projected effects on venomous marine and amphibious creatures with the potential impact on human health. Retrospective analysis of environmental, ecological, and medical literature with a focus on climate change, toxinology, and future modeling specific to venomous aquatic and amphibious creatures. Species included venomous jellyfish, poisonous fish, crown-of-thorns starfish, sea snakes, and toxic frogs. In several projected scenarios, rising temperatures, weather extremes, and shifts in seasons will increase poisonous population numbers, particularly with certain marine creatures like jellyfish and crown-of-thorns starfish. Habitat expansions by lionfish and sea snakes are projected to occur. These phenomena, along with increases in human populations and coastal development will likely increase human-animal encounters. Other species, particularly amphibious toxic frogs, are declining rapidly due to their sensitivity to any temperature change or subtle alterations in the stability of their environment. If temperatures continue to rise to record levels over the next decades, it is predicted that the populations of these once plentiful and critically important animals to the aquatic ecosystem will decline and their geographic distributions will shrink. Review of the literature investigating the effect and forecasts of climate change on venomous marine and amphibious creatures has demonstrated that temperature extremes and changes to climatic norms will likely have a dramatic effect on these toxicological organisms. The effects of climate change on these species through temperature alteration and rising coastal waters will influence each species differently and in turn potentially affect commercial industries, travel, tourism, and human health. Published by Elsevier Inc.

Rising tides, rising gates: The complex ecogeomorphic response of coastal wetlands to sea-level rise and human interventions

NASA Astrophysics Data System (ADS)

Sandi, Steven G.; Rodríguez, José F.; Saintilan, Neil; Riccardi, Gerardo; Saco, Patricia M.

2018-04-01

Coastal wetlands are vulnerable to submergence due to sea-level rise, as shown by predictions of up to 80% of global wetland loss by the end of the century. Coastal wetlands with mixed mangrove-saltmarsh vegetation are particularly vulnerable because sea-level rise can promote mangrove encroachment on saltmarsh, reducing overall wetland biodiversity. Here we use an ecogeomorphic framework that incorporates hydrodynamic effects, mangrove-saltmarsh dynamics, and soil accretion processes to assess the effects of control structures on wetland evolution. Migration and accretion patterns of mangrove and saltmarsh are heavily dependent on topography and control structures. We find that current management practices that incorporate a fixed gate for the control of mangrove encroachment are useful initially, but soon become ineffective due to sea-level rise. Raising the gate, to counteract the effects of sea level rise and promote suitable hydrodynamic conditions, excludes mangrove and maintains saltmarsh over the entire simulation period of 100 years

Doubling of coastal flooding frequency within decades due to sea-level rise

USGS Publications Warehouse

Vitousek, Sean; Barnard, Patrick L.; Fletcher, Charles H.; Frazer, Neil; Erikson, Li; Storlazzi, Curt D.

2017-01-01

Global climate change drives sea-level rise, increasing the frequency of coastal flooding. In most coastal regions, the amount of sea-level rise occurring over years to decades is significantly smaller than normal ocean-level fluctuations caused by tides, waves, and storm surge. However, even gradual sea-level rise can rapidly increase the frequency and severity of coastal flooding. So far, global-scale estimates of increased coastal flooding due to sea-level rise have not considered elevated water levels due to waves, and thus underestimate the potential impact. Here we use extreme value theory to combine sea-level projections with wave, tide, and storm surge models to estimate increases in coastal flooding on a continuous global scale. We find that regions with limited water-level variability, i.e., short-tailed flood-level distributions, located mainly in the Tropics, will experience the largest increases in flooding frequency. The 10 to 20 cm of sea-level rise expected no later than 2050 will more than double the frequency of extreme water-level events in the Tropics, impairing the developing economies of equatorial coastal cities and the habitability of low-lying Pacific island nations.

Thin blue lines: product placement and the drama of pregnancy testing in British cinema and television.

PubMed

Olszynko-Gryn, Jesse

2017-09-01

This article uses the case of pregnancy testing in Britain to investigate the process whereby new and often controversial reproductive technologies are made visible and normalized in mainstream entertainment media. It shows how in the 1980s and 1990s the then nascent product placement industry was instrumental in embedding pregnancy testing in British cinema and television's dramatic productions. In this period, the pregnancy-test close-up became a conventional trope and the thin blue lines associated with Unilever's Clearblue rose to prominence in mainstream consumer culture. This article investigates the aestheticization of pregnancy testing and shows how increasingly visible public concerns about 'schoolgirl mums', abortion and the biological clock, dramatized on the big and small screen, propelled the commercial rise of Clearblue. It argues that the Clearblue close-up ambiguously concealed as much as it revealed; abstraction, ambiguity and flexibility were its keys to success.

The use of 99mTc-HYNIC-TOC and 18F-FDG PET/CT in the evaluation of duodenal neuroendocrine tumor with atypical and extensive metastasis responding dramatically to a single fraction of PRRT with 177Lu-DOTATATE.

PubMed

Basu, Sandip; Abhyankar, Amit

2014-12-01

This report describes a case of extensive diffuse bone marrow involvement with bilateral breast metastases from duodenal neuroendocrine tumor giving rise to a superscan-like appearance on somatostatin receptor-targeted (99m)Tc-hydrazinonicotinamide-TOC scintigraphy. The metastatic lesions demonstrated partial concordance with (18)F-FDG PET/CT findings, signifying varying tumor biology and heterogeneity among metastatic lesions in the same individual, as illustrated with a dual-tracer approach. There was a dramatic symptomatic and biochemical response and better health-related quality of life with a single fraction of peptide receptor radionuclide therapy with (177)Lu-DOTATATE, and radiologically there was stable disease at that point. © 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

[Urinary tract infections in the elderly].

PubMed

Becher, Klaus Friedrich; Klempien, Ingo; Wiedemann, Andreas

2015-10-01

Acute infection of the urinary tract is one of the most commonly encountered bacterial infections in the frail elderly population and is responsible for substantial morbidity and recurrent infections with antibiotic resistance. Although generally considered to be self-limiting without treatment or easily treated with a short antibiotic regime, urinary tract infections (UTIs) often have a dramatic history, associated with incomplete resolution and frequent recurrence. The biological complexity of the infections combined with a dramatic rise in antibiotic-resistant pathogens highlight the need for an anticipating strategy for therapy necessary for a rapid recovery. The first crucial step is the classification in asymptomatic bacteriuria or complicated pyelonephritis, on which the decision for the intensity of treatment and diagnostic effort is based. For the selection of empiric antibiotic therapy, knowledge about the predominant uropathogens as well as local resistance patterns is important. In this manner, most urinary tract infections in the elderly can be treated without greater expense.

Windows into Children's Thinking: A Guide to Storytelling and Dramatization

ERIC Educational Resources Information Center

Wright, Cheryl; Bacigalupa, Chiara; Black, Tyler; Burton, Michael

2008-01-01

Telling and dramatizing stories is an increasingly popular addition to the preschool curriculum, largely due to the attention this activity has received through the writings of Vivian Paley (Bad guys don't have birthdays: fantasy play at four. The University of Chicago Press, Chicago, 1988; The boy who would be a helicopter: the uses of…

Modern Attitudes Toward Older Adults in the Aging World: A Cross-Cultural Meta-Analysis.

PubMed

North, Michael S; Fiske, Susan T

2015-09-01

Prevailing beliefs suggest that Eastern cultures hold older adults in higher esteem than Western cultures do, due to stronger collectivist traditions of filial piety. However, in modern, industrialized societies, the strain presented by dramatic rises in population aging potentially threatens traditional cultural expectations. Addressing these competing hypotheses, a literature search located 37 eligible papers, comprising samples from 23 countries and 21,093 total participants, directly comparing Easterners and Westerners (as classified per U.N. conventions) in their attitudes toward aging and the aged. Contradicting conventional wisdom, a random-effects meta-analysis on these articles found such evaluations to be more negative in the East overall (standardized mean difference = -0.31). High heterogeneity in study comparisons suggested the presence of moderators; indeed, geographical region emerged as a significant moderating factor, with the strongest levels of senior derogation emerging in East Asia (compared with South and Southeast Asia) and non-Anglophone Europe (compared with North American and Anglophone Western regions). At the country level, multiple-moderator meta-regression analysis confirmed recent rises in population aging to significantly predict negative elder attitudes, controlling for industrialization per se over the same time period. Unexpectedly, these analyses also found that cultural individualism significantly predicted relative positivity-suggesting that, for generating elder respect within rapidly aging societies, collectivist traditions may backfire. The findings suggest the importance of demographic challenges in shaping modern attitudes toward elders-presenting considerations for future research in ageism, cross-cultural psychology, and even economic development, as societies across the globe accommodate unprecedented numbers of older citizens. (c) 2015 APA, all rights reserved).

Geriatrics for the 3rd millennium.

PubMed

Cassel, C K

2000-05-05

It is a common knowledge that the population around the world is growing old at an unprecedented rate. This is the success story of increasing life expectancy. The demographic breakthroughs occurred in the 20th century. The quality of life breakthrough is our challenge for the 21st century. The implications of the growing elderly population are many, including: rising total health care expenditures; the increasing needs for long-term care services; and the need for expert and focused health care services. Since health care costs increase with advancing age of populations, these costs will fall on older persons, families, and society generally. There is real value for everyone in meeting the needs of an aging society, especially if seen as part of a social contract. The ability to live independently improves with access to good care, but decreases dramatically for those with age-related disabling conditions. With the decreasing number of informal caregivers around the world, frail elderly will require more formal long-term care services. However, due to inadequate attention given to long-term care issues, numerous developed countries have recently started to struggle to develop long-term care service programs that will both meet the rising needs for this service and be cost-effective. Effective medical care requires expertise in functional assessment, interdisciplinary care, and advances in treating symptoms of aging. The field of geriatrics is essential to modern health care, and geriatricians need to have proper training that focuses diagnosing and treating this group of patients. Quality care will not only help the elderly to live productively and independently, but it will also tremendously benefit families and communities.

The Role of the Department of Defense (DoD) in Solar Energy Research, Development and Diffusion

DTIC Science & Technology

2008-06-01

calculation: 103M gallons x $13.68 (total ownership cost) = $1.4B. 3 Another cost consideration that could be taken into account are the causalities... ownership cost of $1.4B will rise dramatically. 41 • Static structure, no moving parts; hence, no noise. • Longer life with little maintenance because of...instrument in DoD’s energy portfolio for the future. b. Solar vs . Wind: A Further Comparison In 2006, Detronics Limited, a company in Ontario, Canada

ASEAN’S Strategic Approach Towards Security Relations with the U.S. and China: Hedging through a Common Foreign and Security Policy

DTIC Science & Technology

2014-06-13

rising China signals a major shift in the balance of power, and this has long-term and complex ramifications on Asia’s strategic calculus . However...in support of belligerent actions on its neighbors. Either way, it shifts the strategic calculus for ASEAN dramatically. The second assumption is...and Security Policy, and Conflict Resolution: The Future of European (and Global?) Security” (Paper presented at EUSA’s 8th Biennial International

Electrical injuries due to theft of copper.

PubMed

Curinga, Giuseppe; Pietramaggiori, Giorgio; Scherer, Sandra Saja; Masellis, Alessandro; Gherardini, Giulio; Brancato, Renato; Conte, Francesco; Bistoni, Giovanni

2010-01-01

This study shows that the theft of copper, mainly from electrical wires, is becoming a more frequent crime as the value of this metal rises. We have collected all the data from the Burn Centre of the Hospital of Palermo, Italy, from 1992 to 2007. Over the last two decades, we assisted to a dramatic increase of patients admitted to our hospital, reporting burn injuries while attempting to steal it in dangerous conditions. The circumstances of the injury, the clinical management of the case, and the long-term consequences are presented and discussed. We found that the electrical burn related to the theft of copper is often a life-threatening event because of the high-voltage electrical current passing through the patients. Patients, due to the type of activity, often requiring physical effort, were generally young and healthy. From a review of the literature on the subject, we have noticed that theft of copper is not reported as an important risk factor for electrical burns. Our report clearly shows that theft of copper-related electrical injury is becoming more frequent in the community and should be added as a "new" risk factor. The already high incidence reported here may actually be lower than the actual incidence because many patients tend not to come to the hospital because of the risk of being prosecuted by the police.

Comparative assessment of H.265/MPEG-HEVC, VP9, and H.264/MPEG-AVC encoders for low-delay video applications

NASA Astrophysics Data System (ADS)

Grois, Dan; Marpe, Detlev; Nguyen, Tung; Hadar, Ofer

2014-09-01

The popularity of low-delay video applications dramatically increased over the last years due to a rising demand for realtime video content (such as video conferencing or video surveillance), and also due to the increasing availability of relatively inexpensive heterogeneous devices (such as smartphones and tablets). To this end, this work presents a comparative assessment of the two latest video coding standards: H.265/MPEG-HEVC (High-Efficiency Video Coding), H.264/MPEG-AVC (Advanced Video Coding), and also of the VP9 proprietary video coding scheme. For evaluating H.264/MPEG-AVC, an open-source x264 encoder was selected, which has a multi-pass encoding mode, similarly to VP9. According to experimental results, which were obtained by using similar low-delay configurations for all three examined representative encoders, it was observed that H.265/MPEG-HEVC provides significant average bit-rate savings of 32.5%, and 40.8%, relative to VP9 and x264 for the 1-pass encoding, and average bit-rate savings of 32.6%, and 42.2% for the 2-pass encoding, respectively. On the other hand, compared to the x264 encoder, typical low-delay encoding times of the VP9 encoder, are about 2,000 times higher for the 1-pass encoding, and are about 400 times higher for the 2-pass encoding.

Chlorobenzene degeradation by non-thermal plasma combined with EG-TiO2/ZnO as a photocatalyst: Effect of photocatalyst on CO2 selectivity and byproducts reduction.

PubMed

Ghorbani Shahna, Farshid; Bahrami, Abdulrahman; Alimohammadi, Iraj; Yarahmadi, Rassuol; Jaleh, Babak; Gandomi, Mastaneh; Ebrahimi, Hossein; Ad-Din Abedi, Kamal

2017-02-15

The non-thermal plasma (NTP) technique, which suffers from low selectivity in complete oxidation of volatile organic compounds to CO 2 and H 2 O, creates unwanted and harmful byproducts. NTP in concert with photocatalyst can resolve this limitation due to additional oxidation. TiO 2 and ZnO nanoparticles were coated on the surface of the expanded graphite and placed downstream of the NTP reactor under UV light. In this study, to compare the performance of NTP and the combined system, chlorobenzene removal, selectivity of CO 2 and byproducts formation were investigated. The results showed that the combined system enhanced both the removal efficiency and CO 2 selectivity. The output gas of the NTP reactor contained chlorobenzene, phosgene, O 3 , NO, NO 2 , CO, CO 2 , HCL and CL. The bulk of these byproducts was oxidized on the surface of the nanocomposite; as a result, the content of the byproducts in the output gas of the combined system decreased dramatically. The removal efficiency and CO 2 selectivity increased by rising the applied voltage and residence time because the collision between active species and pollutant molecules increases. Based on these results, the combined system is preferred due to a higher performance and lower formation of harmful byproducts. Copyright © 2016 Elsevier B.V. All rights reserved.

Possible connection between large volcanic eruptions and level rise episodes in the Dead Sea Basin

NASA Astrophysics Data System (ADS)

Bookman, R.; Filin, S.; Avni, Y.; Rosenfeld, D.; Marco, S.

2014-12-01

The June 1991 Pinatubo volcanic eruption perturbed the atmosphere, triggering short-term worldwide changes in climate. The following winter was anomalously wet in the Levant, with a ~2-meter increase in the Dead Sea level that created a morphological terrace along the lake's shore. Given the global effects of volcanogenic aerosols, we tested the hypothesis that the 1991-92 shore terrace is a modern analogue to the linkage between past volcanic eruptions and a sequence of shore terraces in the Dead Sea Basin. Analysis of precipitation series from Jerusalem showed a significant positive correlation between the Dust Veil Index (DVI) of the modern eruptions and annual rainfall. The DVI was found to explain nearly 50% of the variability in the annual rainfall, such that greater DVI means more rainfall. Other factors that may affect the annual rainfall in the region as the Southern Oscillation Index (SOI) and the North Atlantic oscillations (NAO) were incorporated along with the DVI in a linear multiple regression model. It was found that the NAO did not contribute anything except for increased noise, but the added SOI increased the explained variability of rainfall to more than 60%. Volcanic eruptions with a VEI of 6, as in the Pinatubo, occurred about once a century during the Holocene and the last glacial-interglacial cycle. This occurrence is similar to the frequency of shore terrace build-up during the Lake Lisan desiccation. Sixteen shore terraces, detected using airborne laser scanning data, were interpreted as indicating short-term level rises due to episodes of enhanced precipitation and runoff during the dramatic drop in Lake Lisan's (palaeo-Dead Sea) level at the end of the LGM. The terraces were compared with a time series of volcanogenic sulfate from the GISP2 record, and similar numbers of sulfate concentration peaks and terraces were found. Furthermore, a significant correlation was found between SO4 concentration peaks and the terraces heights. This correlation may indicate a link between the explosivity, magnitude of stratospheric injection, and the impact on the northern hemisphere water balance. The record of such short-term climato-hydrological effects is made possible by the dramatic desiccation of Lake Lisan. Detailed records of such events provide a demonstration of global climatic teleconnections.

Impacts of climate change and anthropization on groundwater resources in the Nouakchott urban area (coastal Mauritania)

NASA Astrophysics Data System (ADS)

Mohamed, Ahmed-Salem; Leduc, Christian; Marlin, Christelle; Wagué, Oumar; Sidi Cheikh, Mohamed-Ahmed

2017-10-01

Declining groundwater resources in semi-arid areas are often cited because of anthropization and climate change. This is not the case in Nouakchott (Mauritania) where the water level has risen by 1 to 2 m over the last 40 years in parallel with urban expansion (+1 million inhabitants in 60 years). Using former and new data, primarily water table measurements and chemical indicators (major ions, bromide, 18O, 2H), we show that the groundwater level rise is mainly a consequence of the rapid population growth in the Nouakchott area, while the global sea level rise only has a limited impact. The increased supply of domestic water (currently 120,000 m3/day) and the lack of waste water networks have added large amounts of water to the Quaternary aquifer. In this metropolis where 60% of the total area is at an elevation of less than 1 m asl, the rise in the groundwater level has dramatic consequences, including the abandonment of flooded districts, and the emergence of new diseases.

Impact of sea level rise on tide gate function.

PubMed

Walsh, Sean; Miskewitz, Robert

2013-01-01

Sea level rise resulting from climate change and land subsidence is expected to severely impact the duration and associated damage resulting from flooding events in tidal communities. These communities must continuously invest resources for the maintenance of existing structures and installation of new flood prevention infrastructure. Tide gates are a common flood prevention structure for low-lying communities in the tidal zone. Tide gates close during incoming tides to prevent inundation from downstream water propagating inland and open during outgoing tides to drain upland areas. Higher downstream mean sea level elevations reduce the effectiveness of tide gates by impacting the hydraulics of the system. This project developed a HEC-RAS and HEC-HMS model of an existing tide gate structure and its upland drainage area in the New Jersey Meadowlands to simulate the impact of rising mean sea level elevations on the tide gate's ability to prevent upstream flooding. Model predictions indicate that sea level rise will reduce the tide gate effectiveness resulting in longer lasting and deeper flood events. The results indicate that there is a critical point in the sea level elevation for this local area, beyond which flooding scenarios become dramatically worse and would have a significantly negative impact on the standard of living and ability to do business in one of the most densely populated areas of America.

Fiber Reinforced Concrete (FRC) for High Rise Construction: Case Studies

NASA Astrophysics Data System (ADS)

Gharehbaghi, Koorosh; Chenery, Rhea

2017-12-01

Due to its material element, Fiber Reinforced Concrete (FRC) could be stronger than traditional Concrete. This is due to FRC internal material compounds and elements. Furthermore, FRC can also significantly improve flexural strength when compared to traditional Concrete. This improvement in flexural strength can be varied depending on the actual fibers used. Although not new, FRC is gradually gaining popularity in the construction industry, in particular for high rise structures. This is due to its flexural strength, especially for high seismic zones, as it will provide a better solution then reinforced Concrete. The main aim of this paper is to investigate the structural importance of FRC for the high rise construction. Although there has been numerous studies and literature in justifying the FRC for general construction; this paper will consider its use specifically for high rise construction. Moreover, this paper will closely investigate eight case studies from Australian and United States as a part of the FRC validation for high rise construction. In doing so, this paper will examine their Structural Health Monitoring (SHM) to determine their overall structural performance.

Toward evaluating the effect of climate change on investments in the water resources sector: insights from the forecast and analysis of hydrological indicators in developing countries

NASA Astrophysics Data System (ADS)

Strzepek, Kenneth; Jacobsen, Michael; Boehlert, Brent; Neumann, James

2013-12-01

The World Bank has recently developed a method to evaluate the effects of climate change on six hydrological indicators across 8951 basins of the world. The indicators are designed for decision-makers and stakeholders to consider climate risk when planning water resources and related infrastructure investments. Analysis of these hydrological indicators shows that, on average, mean annual runoff will decline in southern Europe; most of Africa; and in southern North America and most of Central and South America. Mean reference crop water deficit, on the other hand, combines temperature and precipitation and is anticipated to increase in nearly all locations globally due to rising global temperatures, with the most dramatic increases projected to occur in southern Europe, southeastern Asia, and parts of South America. These results suggest overall guidance on which regions to focus water infrastructure solutions that could address future runoff flow uncertainty. Most important, we find that uncertainty in projections of mean annual runoff and high runoff events is higher in poorer countries, and increases over time. Uncertainty increases over time for all income categories, but basins in the lower and lower-middle income categories are forecast to experience dramatically higher increases in uncertainty relative to those in the upper-middle and upper income categories. The enhanced understanding of the uncertainty of climate projections for the water sector that this work provides strongly support the adoption of rigorous approaches to infrastructure design under uncertainty, as well as design that incorporates a high degree of flexibility, in response to both risk of damage and opportunity to exploit water supply ‘windfalls’ that might result, but would require smart infrastructure investments to manage to the greatest benefit.

[Psychoactive drugs and costs in the Madrid III (Valdemoro) prison].

PubMed

Algora-Donoso, I; Varela-González, O

2008-01-01

Annual pharmaceutical expenditures in prisons increases dramatically and the rising costs of psychoactive drugs have especially contributed to this. These drugs are often prescribed in order to find therapeutic uses in the field of personality disorders, addictions, and dysfunctional behaviours that are not included in the authorized indications (compassionate use). This study has enabled a detailed description of the use of psychoactive drugs at the Madrid III prison, a centre with one of the lowest levels of pharmaceutical expenditure in this autonomous community. During a two-week period, all prescriptions of psychoactive drugs were collected and registered along with data of several possible conditioning factors. 20.5% of the population was receiving some kind of psychoactive drug; 76% of those inmates undergoing treatment were receiving one or two substances; 65% were taking anxiolytics, 38% antidepressants and 27% antipsychotics. The total amount of psychoactive drugs consumed was 9,840 defined daily doses, 46% of which were anxiolytics, 17% antidepressants and 14% antipsychotics. The total cost of the fortnight's treatment was euros 5,379 with a saving of euro 611 due to requesting and selecting offers carried out by the pharmacist. 72% of the costs were spent on anti-psychotics and the newer psychoactive drugs, representing 66% of the prescriptions, accounted for 98% of expenditure. The prescriber was one of the key influential factors over the amount, type and cost of the treatments. There are signs that compassionate use of current antipsychotics and antiepileptics, and newer antidepressants are a main cause of the dramatic increase in the costs, with cost-efficiency not always clearly demonstrated. These results are not an isolated fact restricted only to prisons, as demonstrated by consumption data published by the National Health System in the same year.

Uderstanding Snowball Earth Deglaciation

NASA Astrophysics Data System (ADS)

Abbot, D. S.

2012-12-01

Earth, a normally clement planet comfortably in its star's habitable zone, suffered global or nearly global glaciation at least twice during the Neoproterozoic era (at about 635 and 710 million years ago). Viewed in the context of planetary evolution, these pan-global glaciations (Snowball Earth events) were extremely rapid, lasting only a few million years. The dramatic effect of the Snowball Earth events on the development of the planet can be seen through their link to rises in atmospheric oxygen and evolutionary innovations. These potential catastrophes on an otherwise clement planet can be used to gain insight into planetary habitability more generally. Since Earth is not currently a Snowball, a sound deglaciation mechanism is crucial for the viability of the Snowball Earth hypothesis. The traditional deglaciation mechanism is a massive build up of CO2 due to reduced weathering during Snowball Earth events until tropical surface temperatures reach the melting point. Once initiated, such a deglaciation might happen on a timescale of only dozens of thousands of years and would thrust Earth from the coldest climate in its history to the warmest. Therefore embedded in Snowball Earth events is an even more rapid and dramatic environmental change. Early global climate model simulations raised doubt about whether Snowball Earth deglaciation could be achieved at a CO2 concentration low enough to be consistent with geochemical data, which represented a potential challenge to the Snowball Earth hypothesis. Over the past few years dust and clouds have emerged as the essential missing additional processes that would allow Snowball Earth deglaciation at a low enough CO2 concentration. I will discuss the dust and cloud mechanisms and the modeling behind these ideas. This effort is critical for the broader implications of Snowball Earth events because understanding the specific deglaciation mechanism determines whether similar processes could happen on other planets.

Using time lapse cameras to monitor shoreline changes due to sea level rise.

DOT National Transportation Integrated Search

2017-01-01

Shoreline habitats and infrastructure are currently being affected by sea level rise (SLR) and as : global temperatures continue to rise, will continue to get worse for millennia. Governments : and individuals decisions to adapt to SLR could ha...

Changing trends in the aetiology, treatment and outcomes of bloodstream infection occurring in the first year after solid organ transplantation: a single-centre prospective cohort study.

PubMed

Oriol, Isabel; Sabé, Núria; Simonetti, Antonella F; Lladó, Laura; Manonelles, Anna; González, Jose; Tubau, Fe; Carratalà, Jordi

2017-09-01

To analyse trends in the aetiology, treatment and outcomes of bloodstream infection (BSI) within the first year post-transplant over the last 10-year period, we prospectively recorded all episodes of BSI occurring in solid organ transplant (SOT) recipients during the first year post-transplant from 2007 to 2016. Trends of factors were analysed by 2-year periods. Of 475 consecutive episodes of BSI, 218 occurred within a year of SOT in 178 SOT recipients. Gram-positive BSI decreased over time (40.5-2.2%). In contrast, there was a steady increase in Gram-negative bacilli (GNB) BSI (54.1-93.3%; P < 0.001), mainly due to Pseudomonas aeruginosa (2.4-20.4%) and Klebsiella pneumoniae (7.1-26.5%). Multidrug-resistant (MDR) GNB (4.8-38.8%; P < 0.001) rose dramatically, especially due to extended-spectrum β-lactamase (ESBL) production (7.1-34.7%). There was a sharp rise in the use of carbapenems, both as empirical (11.9-55.3%; P < 0.001) and as targeted antibiotic treatment (11.9-46.9%; P < 0.001). In conclusion, today, GNB are the leading causative agents of BSI in SOT recipients within the first year after SOT. In addition, MDR GNB have emerged mainly due to ESBL-producing strains. In spite of these changes, length of hospital stay, days of treatment and mortality have remained stable over time. © 2017 Steunstichting ESOT.

Harmful algae and their potential impacts on desalination operations off southern California.

PubMed

Caron, David A; Garneau, Marie-Eve; Seubert, Erica; Howard, Meredith D A; Darjany, Lindsay; Schnetzer, Astrid; Cetinić, Ivona; Filteau, Gerry; Lauri, Phil; Jones, Burton; Trussell, Shane

2010-01-01

Seawater desalination by reverse osmosis (RO) is a reliable method for augmenting drinking water supplies. In recent years, the number and size of these water projects have increased dramatically. As freshwater resources become limited due to global climate change, rising demand, and exhausted local water supplies, seawater desalination will play an important role in the world's future water supply, reaching far beyond its deep roots in the Middle East. Emerging contaminants have been widely discussed with respect to wastewater and freshwater sources, but also must be considered for seawater desalination facilities to ensure the long-term safety and suitability of this emerging water supply. Harmful algal blooms, frequently referred to as 'red tides' due to their vibrant colors, are a concern for desalination plants due to the high biomass of microalgae present in ocean waters during these events, and a variety of substances that some of these algae produce. These compounds range from noxious substances to powerful neurotoxins that constitute significant public health risks if they are not effectively and completely removed by the RO membranes. Algal blooms can cause significant operational issues that result in increased chemical consumption, increased membrane fouling rates, and in extreme cases, a plant to be taken off-line. Early algal bloom detection by desalination facilities is essential so that operational adjustments can be made to ensure that production capacity remains unaffected. This review identifies the toxic substances, their known producers, and our present state of knowledge regarding the causes of toxic episodes, with a special focus on the Southern California Bight. (c) 2009 Elsevier Ltd. All rights reserved.

Effect of a marathon run on serum lipoproteins, creatine kinase, and lactate dehydrogenase in recreational runners.

PubMed

Kobayashi, Yoshio; Takeuchi, Toshiko; Hosoi, Teruo; Yoshizaki, Hidekiyo; Loeppky, Jack A

2005-12-01

The objective of this study was to determine the effect of a marathon run on serum lipid and lipoprotein concentrations and serum muscle enzyme activities and follow their recovery after the run. These blood concentrations were measured before, immediately after, and serially after a marathon run in 15 male recreational runners. The triglyceride level was significantly elevated postrace, then fell 30% below baseline 1 day after the run, and returned to baseline after 1 week. Total cholesterol responded less dramatically but with a similar pattern. High-density lipoprotein cholesterol remained significantly elevated and low-density lipoprotein cholesterol was transiently reduced for 3 days after the run. The total cholesterol/high-density cholesterol ratio was significantly lowered for 3 days. Serum lactate dehydrogenase activity significantly doubled postrace and then declined but remained elevated for 2 weeks. Serum creatine kinase activity peaked 24 hr after the run, with a 15-fold rise, and returned to baseline after 1 week. The rise of these enzymes reflects mechanically damaged muscle cells leaking contents into the interstitial fluid. It is concluded that a prolonged strenuous exercise bout in recreational runners, such as a marathon, produces beneficial changes in lipid blood profiles that are significant for only 3 days. However, muscle damage is also evident for 1 week or more from the dramatic and long-lasting effect on enzyme levels. Laboratory values for these runners were outside normal ranges for some days after the race.

Potential for shoreline changes due to sea-level rise along the U.S. mid-Atlantic region

USGS Publications Warehouse

Gutierrez, Benjamin T.; Williams, S. Jeffress; Thieler, E. Robert

2007-01-01

Sea-level rise over the next century is expected to contribute significantly to physical changes along open-ocean shorelines. Predicting the form and magnitude of coastal changes is important for understanding the impacts to humans and the environment. Presently, the ability to predict coastal changes is limited by the scientific understanding of the many variables and processes involved in coastal change, and the lack of consensus regarding the validity of existing conceptual, analytical, or numerical models. In order to assess potential future coastal changes in the mid-Atlantic U.S. for the U.S. Climate Change Science Program (CCSP), a workshop was convened by the U.S. Geological Survey. Assessments of future coastal change were made by a committee of coastal scientists with extensive professional experience in the mid-Atlantic region. Thirteen scientists convened for a two-day meeting to exchange information and develop a consensus opinion on potential future coastal changes for the mid-Atlantic coast in response to sea-level rise. Using criteria defined in past work, the mid-Atlantic coast was divided into four geomorphic compartments: spits, headlands, wave-dominated barriers, and mixed-energy barriers. A range of potential coastal responses was identified for each compartment based on four sea-level rise scenarios. The four scenarios were based on the assumptions that: a) the long-term sea-level rise rate observed over the 20th century would persist over the 21st century, b) the 20th century rate would increase by 2 mm/yr, c) the 20th century rate would increase by 7 mm/yr, or d) sea-level would rise by 2 m over the next few hundred years. Potential responses to these sea-level rise scenarios depend on the landforms that occur within a region and include increased likelihood for erosion and shoreline retreat for all coastal types, increased likelihood for erosion, overwash and inlet breaching for barrier islands, as well as the possibility of a threshold state (e.g., dramatic change in barrier evolution, such as segmentation or disintegration) for some barrier island systems. The likelihood of the potential coastal responses is expressed using standard terminology employed in climate change assessments (e.g., as used by the Intergovernmental Panel on Climate Change and CCSP). This assessment was based on the coastal geomorphology in its present condition and does not consider any coastal protection that might be undertaken in the future. The committee recognized that a variety of erosion mitigation measures have been implemented along developed portions of the coast and these are very likely to be applied in the future. It was also acknowledged that economics, political will, and other factors can drive decisions to implement these measures, and that such decisions cannot be predicted with confidence. The results of this assessment are depicted graphically on maps of the study area.

Morphological response of the saltmarsh habitats of the Guadiana estuary due to flow regulation and sea-level rise

NASA Astrophysics Data System (ADS)

Sampath, D. M. R.; Boski, T.

2016-12-01

In the context of rapid sea-level rise in the 21st century, the reduction of fluvial sediment supply due to the regulation of river discharge represents a major challenge for the management of estuarine ecosystems. Therefore, the present study aims to assess the cumulative impacts of the reduction of river discharge and projected sea-level rise on the morphological evolution of the Guadiana estuary during the 21st century. The assessment was based on a set of analytical solutions to simplified equations of tidal wave propagation in shallow waters and empirical knowledge of the system. As methods applied to estimate environmental flows do not take into consideration the fluvial discharge required to maintain saltmarsh habitats and the impact of sea-level rise, simulations were carried out for ten cases in terms of base river flow and sea-level rise so as to understand their sensitivity on the deepening of saltmarsh platforms. Results suggest saltmarsh habitats may not be affected severely in response to lower limit scenarios of sea-level rise and sedimentation. A similar behaviour can be expected even due to the upper limit scenarios until 2050, but with a significant submergence afterwards. In the case of the upper limit scenarios under scrutiny, there was a net erosion of sediment from the estuary. Multiplications of amplitudes of the base flow function by factors 1.5, 2, and 5 result in reduction of the estimated net eroded sediment volume by 25, 40, and 80%, respectively, with respect to the net eroded volume for observed river discharge. The results also indicate that defining the minimum environmental flow as a percentage of dry season flow (as done presently) should be updated to include the full spectrum of natural flows, incorporating temporal variability to better anticipate scenarios of sea-level rise during this century. As permanent submergence of intertidal habitats can be significant after 2050, due to the projected 79 cm rise of sea-level by the year 2100, a multi-dimensional approach should be adopted to mitigate the consequences of sea-level rise and strong flow regulations on the ecosystem of the Guadiana Estuary.

A Bayesian explanation of the "Uncanny Valley" effect and related psychological phenomena

NASA Astrophysics Data System (ADS)

Moore, Roger K.

2012-11-01

There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the `uncanny valley' effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well documented, there is no quantitative explanation for the findings and no mathematical model that is capable of predicting such behavior. Here I show (using a Bayesian model of categorical perception) that differential perceptual distortion arising from stimuli containing conflicting cues can give rise to a perceptual tension at category boundaries that could account for these phenomena. The model is not only the first quantitative explanation of the uncanny valley effect, but it may also provide a mathematical explanation for a range of social situations in which conflicting cues give rise to negative, fearful or even violent reactions.

A Bayesian explanation of the ‘Uncanny Valley’ effect and related psychological phenomena

PubMed Central

Moore, Roger K.

2012-01-01

There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the ‘uncanny valley’ effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well documented, there is no quantitative explanation for the findings and no mathematical model that is capable of predicting such behavior. Here I show (using a Bayesian model of categorical perception) that differential perceptual distortion arising from stimuli containing conflicting cues can give rise to a perceptual tension at category boundaries that could account for these phenomena. The model is not only the first quantitative explanation of the uncanny valley effect, but it may also provide a mathematical explanation for a range of social situations in which conflicting cues give rise to negative, fearful or even violent reactions. PMID:23162690

Predictable Unpredictability: the Problem with Basing Medicare Policy on Long-Term Financial Forecasting.

PubMed

Glied, Sherry; Zaylor, Abigail

2015-07-01

The authors assess how Medicare financing and projections of future costs have changed since 2000. They also assess the impact of legislative reforms on the sources and levels of financing and compare cost forecasts made at different times. Although the aging U.S. population and rising health care costs are expected to increase the share of gross domestic product devoted to Medicare, changes made in the program over the past decade have helped stabilize Medicare's financial outlook--even as benefits have been expanded. Long-term forecasting uncertainty should make policymakers and beneficiaries wary of dramatic changes to the program in the near term that are intended to alter its long-term forecast: the range of error associated with cost forecasts rises as the forecast window lengthens. Instead, policymakers should focus on the immediate policy window, taking steps to reduce the current burden of Medicare costs by containing spending today.

Scraping by: Income and Program Participation After the Loss of Extended Unemployment Benefits.

PubMed

Rothstein, Jesse; Valletta, Robert G

Many Unemployment Insurance (UI) recipients do not find new jobs before exhausting their benefits, even when benefits are extended during recessions. Using Survey of Income and Program Participation (SIPP) panel data covering the 2001 and 2007 to 2009 recessions and their aftermaths, we identify individuals whose jobless spells outlasted their UI benefits (exhaustees) and examine household income, program participation, and health-related outcomes during the six months following UI exhaustion. For the average exhaustee, the loss of UI benefits is only slightly offset by increased participation in other safety net programs (e.g., food stamps), and family poverty rates rise substantially. Self-reported disability also rises following UI exhaustion. These patterns do not vary dramatically across household demographic groups, broad income level prior to job loss, or the two business cycles. The results highlight the unique, important role of UI in the U.S. social safety net.

Impacts and responses to sea-level rise: a global analysis of the SRES scenarios over the twenty-first century.

PubMed

Nicholls, Robert J; Tol, Richard S J

2006-04-15

Taking the Special Report on Emission Scenarios (SRES) climate and socio-economic scenarios (A1FI, A2, B1 and B2 'future worlds'), the potential impacts of sea-level rise through the twenty-first century are explored using complementary impact and economic analysis methods at the global scale. These methods have never been explored together previously. In all scenarios, the exposure and hence the impact potential due to increased flooding by sea-level rise increases significantly compared to the base year (1990). While mitigation reduces impacts, due to the lagged response of sea-level rise to atmospheric temperature rise, impacts cannot be avoided during the twenty-first century by this response alone. Cost-benefit analyses suggest that widespread protection will be an economically rational response to land loss due to sea-level rise in the four SRES futures that are considered. The most vulnerable future worlds to sea-level rise appear to be the A2 and B2 scenarios, which primarily reflects differences in the socio-economic situation (coastal population, Gross Domestic Product (GDP) and GDP/capita), rather than the magnitude of sea-level rise. Small islands and deltaic settings stand out as being more vulnerable as shown in many earlier analyses. Collectively, these results suggest that human societies will have more choice in how they respond to sea-level rise than is often assumed. However, this conclusion needs to be tempered by recognition that we still do not understand these choices and significant impacts remain possible. Future worlds which experience larger rises in sea-level than considered here (above 35 cm), more extreme events, a reactive rather than proactive approach to adaptation, and where GDP growth is slower or more unequal than in the SRES futures remain a concern. There is considerable scope for further research to better understand these diverse issues.

Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases.

PubMed

Wan, Wenbin; Cao, Lan; Kalionis, Bill; Xia, Shijin; Tai, Xiantao

2015-01-01

Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons. Incurable neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) show dramatic rising trends particularly in the advanced age groups. However, the underlying mechanisms are not yet fully elucidated, and to date there are no biomarkers for early detection or effective treatments for the underlying causes of these diseases. Furthermore, due to species variation and differences between animal models (e.g., mouse transgenic and knockout models) of neurodegenerative diseases, substantial debate focuses on whether animal and cell culture disease models can correctly model the condition in human patients. In 2006, Yamanaka of Kyoto University first demonstrated a novel approach for the preparation of induced pluripotent stem cells (iPSCs), which displayed similar pluripotency potential to embryonic stem cells (ESCs). Currently, iPSCs studies are permeating many sectors of disease research. Patient sample-derived iPSCs can be used to construct patient-specific disease models to elucidate the pathogenic mechanisms of disease development and to test new therapeutic strategies. Accordingly, the present review will focus on recent progress in iPSC research in the modeling of neurodegenerative disorders and in the development of novel therapeutic options.

Changes in cardiac output and tibial artery flow during and after progressive LBNP

NASA Technical Reports Server (NTRS)

1980-01-01

A 3.0 MHz Pulsed Doppler velocity meter (PD) was used to determine blood velocities in the ascending aorta from the suprasternal notch before, during and after progressive 5 min stages of lower body negative pressure (LBNP) in 7 subjects. Changes in stroke volume were calculated from the systolic velocity integrals. A unique 20 MHz PD was used to estimate bloodflow in the posterior tibial artery. With -20 torr mean stroke volume fell 11% and then continued to decline by 48% before LBNP was terminated. Mean tibial flow fell progressively with LBNP stress, due to an increase in reverse flow component and a reduction in peak forward flow and diameter. Stroke volume increased and heart rate fell dramatically during the first 15 sec of recovery. The LBNP was terminated early in 2 subjects because of vasovagal symptons (V). During V the stroke volume rose 86% which more than compensated for the drop in heart rate. This implies that V is accompanied by a paradoxical increase in venous return and that the reduction in HR is the primary cardiovascular event. During the first 15 sec of recovery these 2 subjects had a distinctive marked rise to heart rate reminiscent of the Bainbridge reflex.

[Forensic age estimation in juveniles and young adults: Reducing the range of scatter in age diagnosis by combining different methods].

PubMed

Schmidt, Sven; Schramm, Danilo; Ribbecke, Sebastian; Schulz, Ronald; Wittschieber, Daniel; Olze, Andreas; Vieth, Volker; Ramsthaler, H Frank; Pfischel, Klaus; Pfeiffer, Heidi; Geserick, Gunther; Schmeling, Andreas

2016-01-01

The dramatic rise in the number of refugees entering Germany means that age estimation for juveniles and young adults whose age is unclear but relevant to legal and official procedures has become more important than ever. Until now, whether and to what extent the combination of methods recommended by the Study Group on Forensic Age Diagnostics has resulted in a reduction of the range of scatter of the summarized age diagnosis has been unclear. Hand skeletal age, third molar mineralization stage and ossification stage of the medial clavicular epiphyses were determined for 307 individuals aged between 10 and 29 at time of death on whom autopsies were performed at the Institutes of Legal Medicine in Berlin, Frankfurt am Main and Hamburg between 2001 and 2011. To measure the range of scatter, linear regression analysis was used to calculate the standard error of estimate for each of the above methods individually and in combination. It was found that combining the above methods led to a reduction in the range of scatter. Due to various limitations of the study, the statistical parameters determined cannot, however, be used for age estimation practice.

Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment.

PubMed

Lee, Jun Hee; Ji, Seung Taek; Kim, Jaeho; Takaki, Satoshi; Asahara, Takayuki; Hong, Young-Joon; Kwon, Sang-Mo

2016-10-28

Although endothelial progenitor cells (EPCs) contribute to wound repair by promoting neovascularization, the mechanism of EPC-mediated wound healing remains poorly understood due to the lack of pivotal molecular targets of dermal wound repair. We found that genetic targeting of the Lnk gene in EPCs dramatically enhances the vasculogenic potential including cell proliferation, migration, and tubule-like formation as well as accelerates in vivo wound healing, with a reduction in fibrotic tissue and improved neovascularization via significant suppression of inflammatory cell recruitment. When injected into wound sites, Lnk -/- EPCs gave rise to a significant number of new vessels, with remarkably increased survival of transplanted cells and decreased recruitment of cytotoxic T cells, macrophages, and neutrophils, but caused activation of fibroblasts in the wound-remodeling phase. Notably, in a mouse model of type I diabetes, transplanted Lnk -/- EPCs induced significantly better wound healing than Lnk +/+ EPCs did. The specific targeting of Lnk may be a promising EPC-based therapeutic strategy for dermal wound healing via improvement of neovascularization but inhibition of excessive inflammation as well as activation of myofibroblasts during dermal tissue remodeling.

Blistering behavior and deuterium retention in tungsten vanadium alloys exposed to deuterium plasma in the linear plasma device STEP

NASA Astrophysics Data System (ADS)

Wang, Jun; Cheng, Long; Yuan, Yue; Qin, Shao-Yang; Arshad, Kameel; Guo, Wang-Guo; Wang, Zheng; Zhou, Zhang-Jian; Lu, Guang-Hong

2018-03-01

The behavior of tungsten-vanadium (W-V) alloys fabricated by powder metallurgy as a plasma facing material has been studied. W-V alloys with different vanadium concentrations (5 and 10 wt %) manufactured by hot pressing (HP) were exposed to deuterium plasma (flux ∼4.6 × 1021 m-2s-1, fluence ∼5.6 × 1025 m-2, ion energy ∼60 eV, target temperature ∼450 K) in the linear plasma device STEP at Beihang University. Three typical grains are observed on HP sintered W-V alloys and exhibit a significant effect on its performance under deuterium plasma irradiation. Surface blistering only occurs at W-enriched grains and is significantly mitigated in W-V alloys, especially in W-10 V, blistering is completely suppressed. On the other hand, deuterium retention dramatically increases in the W-V alloys due to vanadium addition. The deuterium retention in W-5 wt. % V is about 6.2 times more than that in rolled pure W, and this factor further increases to 6.9 when the V concentration rises to 10 wt %. We ascribe these phenomena to the changes of microstructures and components caused by vanadium addition.

Globalization of leptospirosis through travel and migration.

PubMed

Bandara, Medhani; Ananda, Mahesha; Wickramage, Kolitha; Berger, Elisabeth; Agampodi, Suneth

2014-08-12

Leptospirosis remains the most widespread zoonotic disease in the world, commonly found in tropical or temperate climates. While previous studies have offered insight into intra-national and intra-regional transmission, few have analyzed transmission across international borders. Our review aimed at examining the impact of human travel and migration on the re-emergence of Leptospirosis. Results suggest that alongside regional environmental and occupational exposure, international travel now constitute a major independent risk factor for disease acquisition. Contribution of travel associated leptospirosis to total caseload is as high as 41.7% in some countries. In countries where longitudinal data is available, a clear increase of proportion of travel-associated leptospirosis over the time is noted. Reporting patterns is clearly showing a gross underestimation of this disease due to lack of diagnostic facilities. The rise in global travel and eco-tourism has led to dramatic changes in the epidemiology of Leptospirosis. We explore the obstacles to prevention, screening and diagnosis of Leptopirosis in health systems of endemic countries and of the returning migrant or traveler. We highlight the need for developing guidelines and preventive strategies of Leptospirosis related to travel and migration, including enhancing awareness of the disease among health professionals in high-income countries.

US Food and Drug Administration's Risk Evaluation and Mitigation Strategy for extended-release and long-acting opioids: pros and cons, and a European perspective.

PubMed

Mercadante, Sebastiano; Craig, David; Giarratano, Antonello

2012-12-24

Prescriptions for opioid analgesics to manage moderate-to-severe chronic non-cancer pain have increased markedly over the last decade. An unintentional consequence of greater prescription opioid utilization has been the parallel increase in misuse, abuse and overdose, which are serious risks associated with all opioid analgesics. In response to disturbing rises in prescription opioid abuse, the US Food and Drug Administration (FDA) has proposed the implementation of aggressive Risk Evaluation and Mitigation Strategies (REMS). While REMS could dramatically change the development, release, marketing and prescription of extended-release opioids, questions remain on how these programmes may influence prescribing practices, patient safety and ultimately patient access to these agents. The extent of the availability and misuse of prescription opioids in Europe is difficult to assess from the data currently available, due in large part to the considerable differences in prescribing patterns and regulations between countries. Balancing the availability of prescription opioids for those patients who have pain, while discouraging illicit use, is a complex challenge and requires effective efforts on many levels, particularly in Europe where policies are quite different between countries.

Tobacco control in India.

PubMed Central

Shimkhada, Riti; Peabody, John W.

2003-01-01

Legislation to control tobacco use in developing countries has lagged behind the dramatic rise in tobacco consumption. India, the third largest grower of tobacco in the world, amassed 1.7 million disability-adjusted life years (DALYs) in 1990 due to disease and injury attributable to tobacco use in a population where 65% of the men and 38% of the women consume tobacco. India's anti-tobacco legislation, first passed at the national level in 1975, was largely limited to health warnings and proved to be insufficient. In the last decade state legislation has increasingly been used but has lacked uniformity and the multipronged strategies necessary to control demand. A new piece of national legislation, proposed in 2001, represents an advance. It includes the following key demand reduction measures: outlawing smoking in public places; forbidding sale of tobacco to minors; requiring more prominent health warning labels; and banning advertising at sports and cultural events. Despite these measures, the new legislation will not be enough to control the demand for tobacco products in India. The Indian Government must also introduce policies to raise taxes, control smuggling, close advertising loopholes, and create adequate provisions for the enforcement of tobacco control laws. PMID:12640476

Globalization of leptospirosis through travel and migration

PubMed Central

2014-01-01

Leptospirosis remains the most widespread zoonotic disease in the world, commonly found in tropical or temperate climates. While previous studies have offered insight into intra-national and intra-regional transmission, few have analyzed transmission across international borders. Our review aimed at examining the impact of human travel and migration on the re-emergence of Leptospirosis. Results suggest that alongside regional environmental and occupational exposure, international travel now constitute a major independent risk factor for disease acquisition. Contribution of travel associated leptospirosis to total caseload is as high as 41.7% in some countries. In countries where longitudinal data is available, a clear increase of proportion of travel-associated leptospirosis over the time is noted. Reporting patterns is clearly showing a gross underestimation of this disease due to lack of diagnostic facilities. The rise in global travel and eco-tourism has led to dramatic changes in the epidemiology of Leptospirosis. We explore the obstacles to prevention, screening and diagnosis of Leptopirosis in health systems of endemic countries and of the returning migrant or traveler. We highlight the need for developing guidelines and preventive strategies of Leptospirosis related to travel and migration, including enhancing awareness of the disease among health professionals in high-income countries. PMID:25112368

Diet, growth, and obesity development throughout childhood in the Avon Longitudinal Study of Parents and Children

PubMed Central

Jones, Louise R.

2015-01-01

Publications from the Avon Longitudinal Study of Parents and Children covering diet, growth, and obesity development during childhood are reviewed. Diet was assessed by food frequency questionnaires and food records. Growth data were collected by routine measurements, and in standardized clinics, body fatness was assessed by bioelectrical impedance and DXA (dual-energy X-ray absorptiometry) scans. Diets changed dramatically during the preschool period with an increase in the intake of free (added) sugars (12.3% rising to 16.4% of energy) that remained similar until adolescence. This was due to increased intake of energy-dense, nutrient-poor foods. Two periods of rapid growth were identified; infancy and mid-childhood (ages 7–11 y) and both were associated with obesity development. Diets with high energy density were associated with increasing fat mass from mid-childhood until adolescence. Genetic and dietary factors showed independent associations with increasing adiposity. At all ages studied, there were dietary inequalities related to maternal educational attainment that may influence inequalities found in obesity development. The Avon Longitudinal Study of Parents and Children has provided valuable insights into how disparities in diet and growth may affect the development of ill health in adulthood. PMID:26395342

The moral failure of the patriarchy.

PubMed

Watson, J

1990-01-01

The present health care system operates within a larger structure that now has to be openly acknowledged as patriarchal: Caring is viewed as women's work, which is not valued and which is considered less important than the work of men. The moral failure of this worldview is evident in such health care crises as care of the homelessness and those with AIDS, and dramatic rises in rates of infant mortality among the poor. This failure demands a health care revolution--a revolution in the sense that society must give up that which no longer works.

Wrinkle ridges in the floor material of Kasei Valles, Mars: Nature and origin

NASA Technical Reports Server (NTRS)

Watters, Thomas R.; Craddock, Robert A.

1991-01-01

Wrinkle ridges on Mars occur almost exclusively in smooth plains material referred to as ridged plains. One of the largest contiguous units of ridged plains occurs on Lunae Planum on the eastern flank of the Tharsis rise. The eastern, western, and northern margins of the ridged plains of Lunae Planum suffered extensive erosion in early Amazonian channel-forming events. The most dramatic example of erosion in early Amazonian plains is in Kasei Valles. The nature an origin of the wrinkle ridges in the floor material of Kasei Valles are discussed.

The benzil rearrangement reaction: trapping of a hitherto minor product and its application to the development of a selective cyanide anion indicator.

PubMed

Sessler, Jonathan L; Cho, Dong-Gyu

2008-01-03

The isolation and characterization of an intermediate from the benzil-cyanide reaction is reported. The use of this trapping chemistry to produce a chemical indicator for the cyanide anion is described. It relies on the synthesis and reaction of a pi-extended analogue of benzil. Addition of tetrabutylammonium cyanide to organic solutions of this species, referred to as compound 3 in the text, gives rise to a dramatic change in both color and fluorescence properties.

Temperature rise due to mechanical energy dissipation in undirectional thermoplastic composites(AS4/PEEK)

NASA Technical Reports Server (NTRS)

Georgious, I. T.; Sun, C. T.

1992-01-01

The history of temperature rise due to internal dissipation of mechanical energy in insulated off-axis uniaxial specimens of the unidirectional thermoplastic composite (AS4/PEEK) has been measured. The experiment reveals that the rate of temperature rise is a polynomial function of stress amplitude: It consists of a quadratic term and a sixth power term. This fact implies that the specific heat of the composite depends on the stretching its microstructure undergoes during deformation. The Einstein theory for specific heat is used to explain the dependence of the specific heat on the stretching of the microstructure.

White Paper: Summary of the NOAA Workshop - Ecological Effect of Sea Level Rise in the Florida Panhandle and Coastal Alabama: Research and Modeling Needs

EPA Science Inventory

The Center for Sponsored Coastal Ocean Research (CSCOR) is addressing current and future impacts to ecological systems due to the long term effect of sea level rise due to climate change and subsidence on coastal ecosystems through the peer-reviewed research program, the Ecologic...

Lake Urmia (Iran): can future socio-ecologically motivated river basin management restore lake water levels in an arid region with extensive agricultural development?

NASA Astrophysics Data System (ADS)

Fazel, Nasim; Berndtsson, Ronny; Bertacchi Uvo, Cintia; Klove, Bjorn; Madani, Kaveh

2015-04-01

Lake Urmia, one of the world's largest hyper saline lakes located in northwest of Iran, is a UNESCO Biosphere Reserve and Ramsar site, protected as a national park and, supports invaluable and unique biodiversity and related ecosystem services for the region's 6.5 million inhabitants. Due to increased development of the region's water resources for agriculture and industry and to a certain extent climate change, the lake has started to shrink dramatically since 1995 and now is holding less than 30 percent of its volume. Rapid development in agricultural sector and land-use changes has resulted in immense construction of dams and water diversions in almost all lake feeding rivers, intensifying lake shrinking, increasing salinity and degrading its ecosystem. Recently, lake's cultural and environmental importance and social pressure has raised concerns and brought government attention to the lake restoration plans. Along with poor management, low yield agriculture as the most water consuming activity in the region with, rapid, insufficient development is one of the most influential drivers in the lake desiccation. Part of the lake restoration plans in agricultural sector is to restrict the agricultural areas in the main feeding river basins flowing mostly in the southern part of the lake and decreasing the agricultural water use in this area. This study assess the efficiency and effectiveness of the proposed plans and its influence on the lake level rise and its impacts on economy in the region using a system dynamics model developed for the Lake consist of hydrological and agro-economical sub-systems. The effect of decrease in agricultural area in the region on GDP and region economy was evaluated and compared with released water contribution in lake level rise for a five year simulation period.

Interaction between aggrading geomorphic surfaces and the formation of a late pleistocene paleosol in the palouse loess of eastern Washington state

NASA Astrophysics Data System (ADS)

McDonald, Eric V.; Busacca, Alan J.

1990-09-01

Variable rates of loess deposition contributed to dramatic regional variation in a soil-stratigraphic unit, the Washtucna Soil, in the Palouse loess deposits in the Channeled Scabland of eastern Washington state. Throughout most of the Channeled Scabland, the morphology of the Washtucna Soil is that of a single buried soil, but it bifurcates into two well-developed and pedologically distinct buried soils in areas immediately downwind of the major source of loessial sediment. Regional loess stratigraphy confirms that the two well-developed soils formed during the same interval of time during which only one soil formed in areas that are distal to loess source areas. The variable and perhaps rapid rates of soil formation suggested by the stratigraphy resulted from an interaction between variable rates of loess deposition and the formation of superimposed calcic soils. Petrocalcic horizons with weak Stage IV morphology formed as the zone of carbonate accumulation moved up into former A and cambic horizons that had been profusely burrowed by cicadas. The development of cicada burrows in one phase of soil development that were subsequently engulfed by pedogenic carbonate under a rising land surface seems to have greatly accelerated the development of the petrocalcic horizons. Accelerated rates of formation of the petrocalcic horizons occurred when extrinsic (pulses of loess deposition) and intrinsic (engulfment of burrowed horizons) thresholds were exceeded. Stratigraphic evidence suggests that the soil formation that accompanied the rise in the land surface due to additional loess deposition may have occurred during the late Wisconsin glaciation when giant glacial outburst floods in the channeled Scabland triggered a new cycle of loess deposition.

Ice-sheet collapse and sea-level rise at the Bølling warming 14,600 years ago.

PubMed

Deschamps, Pierre; Durand, Nicolas; Bard, Edouard; Hamelin, Bruno; Camoin, Gilbert; Thomas, Alexander L; Henderson, Gideon M; Okuno, Jun'ichi; Yokoyama, Yusuke

2012-03-28

Past sea-level records provide invaluable information about the response of ice sheets to climate forcing. Some such records suggest that the last deglaciation was punctuated by a dramatic period of sea-level rise, of about 20 metres, in less than 500 years. Controversy about the amplitude and timing of this meltwater pulse (MWP-1A) has, however, led to uncertainty about the source of the melt water and its temporal and causal relationships with the abrupt climate changes of the deglaciation. Here we show that MWP-1A started no earlier than 14,650 years ago and ended before 14,310 years ago, making it coeval with the Bølling warming. Our results, based on corals drilled offshore from Tahiti during Integrated Ocean Drilling Project Expedition 310, reveal that the increase in sea level at Tahiti was between 12 and 22 metres, with a most probable value between 14 and 18 metres, establishing a significant meltwater contribution from the Southern Hemisphere. This implies that the rate of eustatic sea-level rise exceeded 40 millimetres per year during MWP-1A.

Mass Balance Changes and Ice Dynamics of Greenland and Antarctic Ice Sheets from Laser Altimetry

NASA Astrophysics Data System (ADS)

Babonis, G. S.; Csatho, B.; Schenk, T.

2016-06-01

During the past few decades the Greenland and Antarctic ice sheets have lost ice at accelerating rates, caused by increasing surface temperature. The melting of the two big ice sheets has a big impact on global sea level rise. If the ice sheets would melt down entirely, the sea level would rise more than 60 m. Even a much smaller rise would cause dramatic damage along coastal regions. In this paper we report about a major upgrade of surface elevation changes derived from laser altimetry data, acquired by NASA's Ice, Cloud and land Elevation Satellite mission (ICESat) and airborne laser campaigns, such as Airborne Topographic Mapper (ATM) and Land, Vegetation and Ice Sensor (LVIS). For detecting changes in ice sheet elevations we have developed the Surface Elevation Reconstruction And Change detection (SERAC) method. It computes elevation changes of small surface patches by keeping the surface shape constant and considering the absolute values as surface elevations. We report about important upgrades of earlier results, for example the inclusion of local ice caps and the temporal extension from 1993 to 2014 for the Greenland Ice Sheet and for a comprehensive reconstruction of ice thickness and mass changes for the Antarctic Ice Sheets.

Trends in Fatalities From Distracted Driving in the United States, 1999 to 2008

PubMed Central

Stimpson, Jim P.

2010-01-01

Objectives. We examined trends in distracted driving fatalities and their relation to cell phone use and texting volume. Methods. The Fatality Analysis Reporting System (FARS) records data on all road fatalities that occurred on public roads in the United States from 1999 to 2008. We studied trends in distracted driving fatalities, driver and crash characteristics, and trends in cell phone use and texting volume. We used multivariate regression analysis to estimate the relation between state-level distracted driving fatalities and texting volumes. Results. After declining from 1999 to 2005, fatalities from distracted driving increased 28% after 2005, rising from 4572 fatalities to 5870 in 2008. Crashes increasingly involved male drivers driving alone in collisions with roadside obstructions in urban areas. By use of multivariate analyses, we predicted that increasing texting volumes resulted in more than 16 000 additional road fatalities from 2001 to 2007. Conclusions. Distracted driving is a growing public safety hazard. Specifically, the dramatic rise in texting volume since 2005 appeared to be contributing to an alarming rise in distracted driving fatalities. Legislation enacting texting bans should be paired with effective enforcement to deter drivers from using cell phones while driving. PMID:20864709

Trends in fatalities from distracted driving in the United States, 1999 to 2008.

PubMed

Wilson, Fernando A; Stimpson, Jim P

2010-11-01

We examined trends in distracted driving fatalities and their relation to cell phone use and texting volume. The Fatality Analysis Reporting System (FARS) records data on all road fatalities that occurred on public roads in the United States from 1999 to 2008. We studied trends in distracted driving fatalities, driver and crash characteristics, and trends in cell phone use and texting volume. We used multivariate regression analysis to estimate the relation between state-level distracted driving fatalities and texting volumes. After declining from 1999 to 2005, fatalities from distracted driving increased 28% after 2005, rising from 4572 fatalities to 5870 in 2008. Crashes increasingly involved male drivers driving alone in collisions with roadside obstructions in urban areas. By use of multivariate analyses, we predicted that increasing texting volumes resulted in more than 16,000 additional road fatalities from 2001 to 2007. Distracted driving is a growing public safety hazard. Specifically, the dramatic rise in texting volume since 2005 appeared to be contributing to an alarming rise in distracted driving fatalities. Legislation enacting texting bans should be paired with effective enforcement to deter drivers from using cell phones while driving.

Update on abortion policy.

PubMed

Conti, Jennifer A; Brant, Ashley R; Shumaker, Heather D; Reeves, Matthew F

2016-12-01

To review the status of antiabortion restrictions enacted over the last 5 years in the United States and their impact on abortion services. In recent years, there has been an alarming rise in the number of antiabortion laws enacted across the United States. In total, various states in the union enacted 334 abortion restrictions from 2011 to July 2016, accounting for 30% of all abortion restrictions since the legalization of abortion in 1973. Data confirm, however, that more liberal abortion laws do not increase the number of abortions, but instead greatly decrease the number of abortion-related deaths. Several countries including Romania, South Africa and Nepal have seen dramatic decreases in maternal mortality after liberalization of abortion laws, without an increase in the total number of abortions. In the United States, abortions are incredibly safe with very low rates of complications and a mortality rate of 0.7 per 100 000 women. With increasing abortion restrictions, maternal mortality in the United States can be expected to rise over the coming years, as has been observed in Texas recently. Liberalization of abortion laws saves women's lives. The rising number of antiabortion restrictions will ultimately harm women and their families.

Globalisation of inflammatory bowel disease: perspectives from the evolution of inflammatory bowel disease in the UK and China.

PubMed

Kaplan, Gilaad G; Ng, Siew C

2016-12-01

The UK and China provide unique historical perspectives on the evolution of the incidence of inflammatory bowel disease, which might provide insight into its pathogenesis. Historical records from the UK document the emergence of ulcerative colitis during the mid-1800s, which was later followed by the recognition of Crohn's disease in 1932. During the second half of the 20th century, the incidence of inflammatory bowel disease rose dramatically in high-income countries. Globalisation at the turn of the 21st century led to rapid economic development of newly industrialised countries such as China. In China, the modernisation of society was accompanied by the recognition of a sharp rise in the incidence of inflammatory bowel disease. The prevalence of inflammatory bowel disease is expected to continue to rise in high-income countries and is also likely to accelerate in the developing world. An understanding of the shared and different environmental determinants underpinning the pathogenesis of inflammatory bowel disease in western and eastern countries is essential to implement interventions that will blunt the rising global burden of inflammatory bowel disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

From tunable core-shell nanoparticles to plasmonic drawbridges: Active control of nanoparticle optical properties

PubMed Central

Byers, Chad P.; Zhang, Hui; Swearer, Dayne F.; Yorulmaz, Mustafa; Hoener, Benjamin S.; Huang, Da; Hoggard, Anneli; Chang, Wei-Shun; Mulvaney, Paul; Ringe, Emilie; Halas, Naomi J.; Nordlander, Peter; Link, Stephan; Landes, Christy F.

2015-01-01

The optical properties of metallic nanoparticles are highly sensitive to interparticle distance, giving rise to dramatic but frequently irreversible color changes. By electrochemical modification of individual nanoparticles and nanoparticle pairs, we induced equally dramatic, yet reversible, changes in their optical properties. We achieved plasmon tuning by oxidation-reduction chemistry of Ag-AgCl shells on the surfaces of both individual and strongly coupled Au nanoparticle pairs, resulting in extreme but reversible changes in scattering line shape. We demonstrated reversible formation of the charge transfer plasmon mode by switching between capacitive and conductive electronic coupling mechanisms. Dynamic single-particle spectroelectrochemistry also gave an insight into the reaction kinetics and evolution of the charge transfer plasmon mode in an electrochemically tunable structure. Our study represents a highly useful approach to the precise tuning of the morphology of narrow interparticle gaps and will be of value for controlling and activating a range of properties such as extreme plasmon modulation, nanoscopic plasmon switching, and subnanometer tunable gap applications. PMID:26665175

Hurricane Wilma's impact on overall soil elevation and zones within the soil profile in a mangrove forest

USGS Publications Warehouse

Whelan, K.R.T.; Smith, T. J.; Anderson, G.H.; Ouellette, M.L.

2009-01-01

Soil elevation affects tidal inundation period, inundation frequency, and overall hydroperiod, all of which are important ecological factors affecting species recruitment, composition, and survival in wetlands. Hurricanes can dramatically affect a site's soil elevation. We assessed the impact of Hurricane Wilma (2005) on soil elevation at a mangrove forest location along the Shark River in Everglades National Park, Florida, USA. Using multiple depth surface elevation tables (SETs) and marker horizons we measured soil accretion, erosion, and soil elevation. We partitioned the effect of Hurricane Wilma's storm deposit into four constituent soil zones: surface (accretion) zone, shallow zone (0–0.35 m), middle zone (0.35–4 m), and deep zone (4–6 m). We report expansion and contraction of each soil zone. Hurricane Wilma deposited 37.0 (± 3.0 SE) mm of material; however, the absolute soil elevation change was + 42.8 mm due to expansion in the shallow soil zone. One year post-hurricane, the soil profile had lost 10.0 mm in soil elevation, with 8.5 mm of the loss due to erosion. The remaining soil elevation loss was due to compaction from shallow subsidence. We found prolific growth of new fine rootlets (209 ± 34 SE g m−2) in the storm deposited material suggesting that deposits may become more stable in the near future (i.e., erosion rate will decrease). Surficial erosion and belowground processes both played an important role in determining the overall soil elevation. Expansion and contraction in the shallow soil zone may be due to hydrology, and in the middle and bottom soil zones due to shallow subsidence. Findings thus far indicate that soil elevation has made substantial gains compared to site specific relative sea-level rise, but data trends suggest that belowground processes, which differ by soil zone, may come to dominate the long term ecological impact of storm deposit.

Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor

PubMed Central

Majuta, Lisa A.; Longo, Geraldine; Fealk, Michelle N.; McCaffrey, Gwen; Mantyh, Patrick W.

2015-01-01

The number of patients suffering from postoperative pain due to orthopedic surgery and bone fracture is projected to dramatically increase because the human life span, weight, and involvement in high-activity sports continue to rise worldwide. Joint replacement or bone fracture frequently results in skeletal pain that needs to be adequately controlled for the patient to fully participate in needed physical rehabilitation. Currently, the 2 major therapies used to control skeletal pain are nonsteroidal anti-inflammatory drugs and opiates, both of which have significant unwanted side effects. To assess the efficacy of novel therapies, mouse models of orthopedic and fracture pain were developed and evaluated here. These models, orthopedic surgery pain and bone fracture pain, resulted in skeletal pain–related behaviors that lasted 3 weeks and 8 to 10 weeks, respectively. These skeletal pain behaviors included spontaneous and palpation-induced nocifensive behaviors, dynamic weight bearing, limb use, and voluntary mechanical loading of the injured hind limb. Administration of anti–nerve growth factor before orthopedic surgery or after bone fracture attenuated skeletal pain behaviors by 40% to 70% depending on the end point being assessed. These data suggest that nerve growth factor is involved in driving pain due to orthopedic surgery or bone fracture. These animal models may be useful in developing an understanding of the mechanisms that drive postoperative orthopedic and bone fracture pain and the development of novel therapies to treat these skeletal pains. PMID:25599311

Advanced manufacturing: Technology and international competitiveness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tesar, A.

1995-02-01

Dramatic changes in the competitiveness of German and Japanese manufacturing have been most evident since 1988. All three countries are now facing similar challenges, and these challenges are clearly observed in human capital issues. Our comparison of human capital issues in German, Japanese, and US manufacturing leads us to the following key judgments: Manufacturing workforces are undergoing significant changes due to advanced manufacturing technologies. As companies are forced to develop and apply these technologies, the constituency of the manufacturing workforce (especially educational requirements, contingent labor, job content, and continuing knowledge development) is being dramatically and irreversibly altered. The new workforcemore » requirements which result due to advanced manufacturing require a higher level of worker sophistication and responsibility.« less

Large Eddy Simulation of Supersonic Inlet Flows

DTIC Science & Technology

1998-04-01

shock/turbulence interaction in order to identify and explain factors important in shock/boundary layer interaction. Direct numerical simulation of a... factors : increase in the adverse pressure rise (due to pm2 increasing while pcl decreases) and decrease in streamwise momentum flux (due to pc...momentum flux. Both factors make the vortex more susceptible to breakdown. This implies that if the free-stream pressure rise exceeds the axial

Sea level rise in the Severn Estuary and Bristol Channel and impacts of a Severn Barrage

NASA Astrophysics Data System (ADS)

Ahmadian, Reza; Olbert, Agnieszka I.; Hartnett, Michael; Falconer, Roger A.

2014-05-01

Many research projects in recent years have focused on marine renewable energy devices and structures due to the growing interest in marine renewable energy. These devices and structures have very different life spans. Schemes such as the Severn Barrage in the UK, as originally proposed by the Severn Tidal Power Group (STPG), would be the largest tidal renewable energy generation project in the world and would be operational for well over a century if built. Due to the long working life of some of these marine renewable energy schemes, it is important to study the impacts of climate change on such schemes, and particularly sea level rise. This study focuses on investigating the impacts of sea level rise due to climate change on the largest macro-tidal estuary in the UK, namely the Severn Estuary and Bristol Channel, and the alterations of the impacts and the performance of the Severn Barrage as a result of climate change. A hierarchy of computer models was implemented to identify the more localised impacts of climate change in the region of the study. Moreover, the potential benefits of the barrage on reducing flood risk, as well as the impact of climate change and the barrage on intertidal mudflats were investigated. The model predictions showed that the barrage would reduce flood risk due to the sea level rise. Furthermore, annual power output and the initial reduction in flood risk of the barrage would not be affected by sea level rise.

Implications on 1 + 1 D Tsunami Runup Modeling due to Time Features of the Earthquake Source

NASA Astrophysics Data System (ADS)

Fuentes, M.; Riquelme, S.; Ruiz, J.; Campos, J.

2018-02-01

The time characteristics of the seismic source are usually neglected in tsunami modeling, due to the difference in the time scale of both processes. Nonetheless, there are just a few analytical studies that intended to explain separately the role of the rise time and the rupture velocity. In this work, we extend an analytical 1 + 1 D solution for the shoreline motion time series, from the static case to the kinematic case, by including both rise time and rupture velocity. Our results show that the static case corresponds to a limit case of null rise time and infinite rupture velocity. Both parameters contribute in shifting the arrival time, but maximum runup may be affected by very slow ruptures and long rise time. Parametric analysis reveals that runup is strictly decreasing with the rise time while is highly amplified in a certain range of slow rupture velocities. For even lower rupture velocities, the tsunami excitation vanishes and for larger, quicker approaches to the instantaneous case.

Consequences of sea level variability and sea level rise for Cuban territory

NASA Astrophysics Data System (ADS)

Hernández, M.; Martínez, C. A.; Marzo, O.

2015-03-01

The objective of the present paper was to determine a first approximation of coastal zone flooding by 2100, taking into account the more persistent processes of sea level variability and non-accelerated linear sea level rise estimation to assess the main impacts. The annual linear rate of mean sea level rise in the Cuban archipelago, obtained from the longest tide gauge records, has fluctuated between 0.005 cm/year at Casilda and 0.214 cm/year at Siboney. The main sea level rise effects for the Cuban coastal zone due to climate change and global warming are shown. Monthly and annual mean sea level anomalies, some of which are similar to or higher than the mean sea level rise estimated for halfway through the present century, reinforce the inland seawater penetration due to the semi-daily high tide. The combination of these different events will result in the loss of goods and services, and require expensive investments for adaption.

Implications on 1 + 1 D Tsunami Runup Modeling due to Time Features of the Earthquake Source

NASA Astrophysics Data System (ADS)

Fuentes, M.; Riquelme, S.; Ruiz, J.; Campos, J.

2018-04-01

The time characteristics of the seismic source are usually neglected in tsunami modeling, due to the difference in the time scale of both processes. Nonetheless, there are just a few analytical studies that intended to explain separately the role of the rise time and the rupture velocity. In this work, we extend an analytical 1 + 1 D solution for the shoreline motion time series, from the static case to the kinematic case, by including both rise time and rupture velocity. Our results show that the static case corresponds to a limit case of null rise time and infinite rupture velocity. Both parameters contribute in shifting the arrival time, but maximum runup may be affected by very slow ruptures and long rise time. Parametric analysis reveals that runup is strictly decreasing with the rise time while is highly amplified in a certain range of slow rupture velocities. For even lower rupture velocities, the tsunami excitation vanishes and for larger, quicker approaches to the instantaneous case.

Managing for No Net Loss of Ecological Services: An Approach for Quantifying Loss of Coastal Wetlands due to Sea Level Rise

NASA Astrophysics Data System (ADS)

Kassakian, Jennifer; Jones, Ann; Martinich, Jeremy; Hudgens, Daniel

2017-05-01

Sea level rise has the potential to substantially alter the extent and nature of coastal wetlands and the critical ecological services they provide. In making choices about how to respond to rising sea level, planners are challenged with weighing easily quantified risks (e.g., loss of property value due to inundation) against those that are more difficult to quantify (e.g., loss of primary production or carbon sequestration services provided by wetlands due to inundation). Our goal was to develop a cost-effective, appropriately-scaled, model-based approach that allows planners to predict, under various sea level rise and response scenarios, the economic cost of wetland loss—with the estimates proxied by the costs of future restoration required to maintain the existing level of wetland habitat services. Our approach applies the Sea Level Affecting Marshes Model to predict changes in wetland habitats over the next century, and then applies Habitat Equivalency Analysis to predict the cost of restoration projects required to maintain ecological services at their present, pre-sea level rise level. We demonstrate the application of this approach in the Delaware Bay estuary and in the Indian River Lagoon (Florida), and discuss how this approach can support future coastal decision-making.

Managing for No Net Loss of Ecological Services: An Approach for Quantifying Loss of Coastal Wetlands due to Sea Level Rise.

PubMed

Kassakian, Jennifer; Jones, Ann; Martinich, Jeremy; Hudgens, Daniel

2017-05-01

Sea level rise has the potential to substantially alter the extent and nature of coastal wetlands and the critical ecological services they provide. In making choices about how to respond to rising sea level, planners are challenged with weighing easily quantified risks (e.g., loss of property value due to inundation) against those that are more difficult to quantify (e.g., loss of primary production or carbon sequestration services provided by wetlands due to inundation). Our goal was to develop a cost-effective, appropriately-scaled, model-based approach that allows planners to predict, under various sea level rise and response scenarios, the economic cost of wetland loss-with the estimates proxied by the costs of future restoration required to maintain the existing level of wetland habitat services. Our approach applies the Sea Level Affecting Marshes Model to predict changes in wetland habitats over the next century, and then applies Habitat Equivalency Analysis to predict the cost of restoration projects required to maintain ecological services at their present, pre-sea level rise level. We demonstrate the application of this approach in the Delaware Bay estuary and in the Indian River Lagoon (Florida), and discuss how this approach can support future coastal decision-making.

The Rising Price of Objectivity: Philanthropy, Government, and the Future of Education Research

ERIC Educational Resources Information Center

Feuer, Michael J.

2016-01-01

In "The Rising Price of Objectivity," Michael J. Feuer describes what he sees as a "perfect storm" gathering in the sea of education research. He notes the convergence of three important trends: first, the rise in strategic education philanthropy; second, the decline in federal funding, in part due to ideologically contested…

Wave-Wave Coupling and Disasters: The 1985 Mexico Earthquake and the 2001 WTC Collapse

NASA Astrophysics Data System (ADS)

Lomnitz, C.

2002-12-01

Wave-wave coupling occurs in the presence of weak nonlinearity. It can generate quite dramatic, unexpected effects. In the 1985 earthquake disaster in Mexico City more than 400 high-rise buildings collapsed on soft ground with a loss of life of around 10,000. The emergence of a large, monochromatic, coherent ground wave was an unforeseen factor. Linear modeling failed to reproduce the main features of this signal including the prominent spectral peak close to the resonant frequency of the high-rise buildings, and an extremely long time duration (more than five minutes). The signal was apparently due to coupling of a fundamental Rayleigh mode to the quarter-wavelength shear resonance in the surface mud layer through their common frequency at 0.4 Hz. An additional unexpected feature was the low attenuation of these modes in the mud layer, and the presence of prograde particle motion. Prograde rotation, though not necessarily caused by nonlinear effects, will couple with structural modes of vibration that tend to destabilize a tall building, much like a tall ship in ocean waves. Such unanticipated features may play a critical role in earthquake disasters on soft ground. A related case is the World Trade Center disaster of 11 September 2001, which was presumed to be due to gradual heat softening of steel girders. If so, the Twin Towers should have leaned over sideways but actually the collapse occurred vertically and quite suddenly. A likely alternative is coupling between a fireball caused by a phase transition between low- and high-oxygen consumption modes in burning jet fuel: (low-oxygen) 2CnH2n+2 + (n+1)O2 = nC2 + (2n+2)H2O, (1) (high-oxygen) 2CnH2n+2 + (3n+1)O2 = 2nCO2 + (2n+2)H2O, (2) and a pressure pulse propagating vertically inside the tubular structure. The pulse would have taken out the concrete floors, thus initiating collapse by implosion of the structural shell. Linear thinking may fail to anticipate coupling, and thus appropriate preventive measures may not be provided.

Comparative Paleomagnetic Study of the Quaternary-Pliocene Sedimentation Rates in the Arctic Basin: First Results

NASA Astrophysics Data System (ADS)

Elkina, D.; Piskarev, A.

2017-12-01

Accurate dating of marine sediments from the Arctic Basin continues to remain a subject of great debates over the last decades. Due to the lack of adequate materials for biostratigraphy, and isotope analyses, paleomagnetic reconstructions came on line here but still yielded ambivalent interpretations. Moreover, sedimentation rates, estimated for isolated morphological features in the Arctic Ocean, are often extended to the whole Basin and, therefore, lead to significant approximations of the sedimentation pattern distribution. Paleomagnetic study of two sediment cores up to 8 meter long, collected at the Mendeleev Rise, and the Lomonosov Ridge, have provided the opportunity to compare sedimentation regimes on these two profound structures of the Arctic Basin. Cores PS72/396 and PS87/023 were carried out along the cruises of RV Polarstern at the Mendeleev Rise (Stein et. al, 2010), and the Lomonosov Ridge (Stein, 2015) respectively. Measurements of natural remanent magnetization (NRM) and anhysteretic remanence (ARM) acquisition with the following alternating field (AF) demagnetization were performed on u-channel samples, obtained from the cores, at the Center for Geo-Environmental Research and Modeling (GEOMODEL) of the Research Park, St. Petersburg State University. According to preliminary results, core PS72/396 has shown a change from positive to negative inclinations at ca. 120 cm below sea floor (cmbsf), prevailed up to ca. 360 cmbsf where it gets back to the positive ones. This trend is comparable with some previous paleomagnetic results, conducted on cores from the Mendeleev Rise (Piskarev et al., 2013; Elkina, 2014). In contrast, for core PS87/023, a relevant drop to negative inclinations can be observed only after 330 cmbsf. That could signify a dramatic difference in sedimentation rates between the sites during the Quaternary and Pliocene. Nevertheless, a rather complicated picture of the AF data assumes effects of secondary overprints, having influenced the initial magnetization pattern for the both regions studied, manifested for the Lomonosov Ridge in great measure. AcknowledgmentsThe current study is conducted in collaboration with the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research.

Global Coastal Exposure due to Sea-level Rise beyond Tipping Points with Multiple Warming Pathways

NASA Astrophysics Data System (ADS)

Tawatari, R.; Iseri, Y.; Kiguchi, M.; Kanae, S.

2016-12-01

Sea-level is observed and estimated to continue rising. In the future, the rise could be abrupt and irreversible in century to millennial timescale even if we conduct strong reduction of greenhouse gas emission. Greenland ice sheet and West Antarctic ice sheet are considered as attributable climate systems which would significantly enhance presently-projected sea-level rise by several meters if global mean temperature passes certain "Tipping points" which would exist around +1-5 degree Celsius above present temperature (1980-1999 average). Therefore, vulnerable coastal low-lying area, especially small islands, deltas or poor developing countries, would suffer from semi-permanent inundation and forced to counteract due to the enhanced sea-level rise. This study estimate range of sea-level rise until the year 2300 and 3000 considering excess of tipping points with using multiple levels of temperature scenarios which consist of excess tipping points and non-excess tipping points pathways. We extract state-of-the-art knowledge of tipping elements from paper reviewing to express reasonable relationship between temperature and abruptly-changing sea-level transition across the ages. This study also calculate coastal exposure globally as affected population, area and asset below the estimated sea-level for each countries with overlaying 30 arc-second gridded topography, population distribution and the sea-level. The result indicates which country would be critically affected if we follow overshooting pathways. Furthermore, this study visualize uncertain coastal exposure due to sea-level rise in the future from the multiple warming pathways. This estimation of possible future beyond tipping point would be useful information for decision-makers to establish new planning of defense, migration or mitigation for the future societies.

46 CFR 164.008-4 - Test requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... thermocouples on the unexposed surface described in § 164.008-3(f)(2) will not rise more than 139 °C. (250 °F..., rise more than 225 °C. (405 °F.) above the initial temperature at the end of 15 minutes. When failure is due to excessive temperature rise on the joint, consideration will be given to alternate joint...

76 FR 36318 - Safety Zone; Waterway Closure, Morgan City-Port Allen Route From Mile Marker 0 to Port Allen Lock

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... to hazards associated with rising flood water. DATES: Effective Date: this rule is effective in the..., vessels and tows from the hazards associated with rising flood water on the Morgan City-Port Allen Route... system, vessels and tows from destruction, loss or injury due to the hazards associated with rising flood...

46 CFR 164.008-4 - Test requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... thermocouples on the unexposed surface described in § 164.008-3(f)(2) will not rise more than 139 °C. (250 °F..., rise more than 225 °C. (405 °F.) above the initial temperature at the end of 15 minutes. When failure is due to excessive temperature rise on the joint, consideration will be given to alternate joint...

76 FR 38013 - Safety Zone; Big Sioux River From the Military Road Bridge North Sioux City to the Confluence of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... rising flood water. Operation in this zone is restricted unless specifically authorized by the Captain of... rising flood water. The impacts on routine navigation are expected to be minimal. Small Entities Under... vessels from destruction, loss or injury due to the hazards associated with rising flood water. If you are...

Validation of smoke plume rise models using ground based lidar

Treesearch

Cyle E. Wold; Shawn Urbanski; Vladimir Kovalev; Alexander Petkov; Wei Min Hao

2010-01-01

Biomass fires can significantly degrade regional air quality. Plume rise height is one of the critical factors determining the impact of fire emissions on air quality. Plume rise models are used to prescribe the vertical distribution of fire emissions which are critical input for smoke dispersion and air quality models. The poor state of model evaluation is due in...

Environmental effects on long term behavior of composite laminates

NASA Astrophysics Data System (ADS)

Singhal, S. N.; Chamis, C. C.

Model equations are presented for approximate methods simulating the long-term behavior of composite materials and structures in hot/humid service environments. These equations allow laminate property upgradings with time, and can account for the effects of service environments on creep response. These methodologies are illustrated for various individual and coupled temperature/moisture, longitudinal/transverse, and composite material type cases. Creep deformation is noted to rise dramatically for cases of matrix-borne, but not of fiber-borne, loading in hot, humid environments; the coupled influence of temperature and moisture is greater than a mere combination of their individual influences.

Environmental effects on long term behavior of composite laminates

NASA Technical Reports Server (NTRS)

Singhal, S. N.; Chamis, C. C.

1992-01-01

Model equations are presented for approximate methods simulating the long-term behavior of composite materials and structures in hot/humid service environments. These equations allow laminate property upgradings with time, and can account for the effects of service environments on creep response. These methodologies are illustrated for various individual and coupled temperature/moisture, longitudinal/transverse, and composite material type cases. Creep deformation is noted to rise dramatically for cases of matrix-borne, but not of fiber-borne, loading in hot, humid environments; the coupled influence of temperature and moisture is greater than a mere combination of their individual influences.

Isolated Hepatic Metastasis from Prostate Carcinoma.

PubMed

Wang, Stephani C; McCarthy, Lezah P; Mehdi, Syed

2017-01-01

Worldwide, prostate cancer is considered the second most common cancer in men. Most common sites for metastatic disease are lymph nodes and bones. However, isolated liver metastasis from prostate cancer is rare. We present a 75 year-old male with prostate adenocarcinoma diagnosed 7 years ago. With rising PSA, he underwent imaging and found to have isolated hepatic metastasis. After left hepatic lobectomy, his PSA dramatically decreased to < 0.01. Physicians should be aware of isolated hepatic metastasis in patients with prostate cancer. Metastasectomy should be considered in such case, and combined medical and surgical approach may prolong the overall survival.

The evolving high: new designer drugs of abuse.

PubMed

Pourmand, A; Armstrong, P; Mazer-Amirshahi, M; Shokoohi, H

2014-10-01

Over the past decade, emerging drugs of abuse and synthetic derivatives of more traditional agents have flooded the market. While Europe was the first to experience a surge in the use of drugs such as synthetic cathinones and cannabinoids, poison centers throughout the United States have seen a dramatic rise in calls related to these new designer drugs of abuse. In the majority of cases, care is largely supportive but significant medical and traumatic complications may occur. Providers must be aware of the ever-changing trends in abuse, so that they may optimally care for poisoned patients. © The Author(s) 2014.

Former Yugoslav Republic of Macedonia: The Emergence of the ’New Macedonian Question’ in the Remains of Second Yugoslavia. Survivability of the New Postcold War State in the Balkans

DTIC Science & Technology

2001-12-01

Recently, there has been a dramatic rise in the drug trade, as Skopje is on the heroin route from Turkey to the Adriatic coast and Italian mafia cartels...links. Most of them went along the old traditional route of Nis- Skopje - Thessaloniki. It is by now very obvious to observers that the geopolitics of...the New Post-Cold War State in the Balkans 6 . AUTHOR(S) Charalampos Lekkas 5. FUNDING NUMBERS 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS

A Volcanic Fissure

NASA Image and Video Library

2017-04-26

Although Mars is known for having the largest volcano in our solar system, Olympus Mons, we also find small-scale volcanic features on its surface, as shown in this image from HiRISE onboard NASA's Mars Reconnaissance Orbiter (MRO). This fissure, less than 500 meters across at its widest point, lies in the Tharsis region and is believed to be a vent from which lava flowed in ancient eruptions. The total volume of lava released from this fissure is much less than what would erupt from nearby volcanoes, but the mark left on the landscape is dramatic nonetheless. https://photojournal.jpl.nasa.gov/catalog/PIA21601

The effect of price increases on contraceptive sales in Bangladesh.

PubMed

Ciszewski, R L; Harvey, P D

1994-01-01

In April 1990, the prices of five brands of contraceptives in the Bangladesh social marketing project were increased, by an average of 60%. The impact on condom sales was immediate and severe, with sales for the following 12 months dropping by 46% from the average during the preceding 12 months. The effect on oral contraceptive sales was less dramatic: average sales in the year following the increases dropped slightly despite a previously established pattern of rapidly rising sales. There appears no reasonable combination of events other than the price increase itself to explain most of the difference.

Impurity-induced tuning of quantum-well States in spin-dependent resonant tunneling.

PubMed

Kalitsov, Alan; Coho, A; Kioussis, Nicholas; Vedyayev, Anatoly; Chshiev, M; Granovsky, A

2004-07-23

We report exact model calculations of the spin-dependent tunneling in double magnetic tunnel junctions in the presence of impurities in the well. We show that the impurity can tune selectively the spin channels giving rise to a wide variety of interesting and novel transport phenomena. The tunneling magnetoresistance, the spin polarization, and the local current can be dramatically enhanced or suppressed by impurities. The underlying mechanism is the impurity-induced shift of the quantum well states (QWSs), which depends on the impurity potential, impurity position, and the symmetry of the QWS. Copyright 2004 The American Physical Society

Microdose gonadotropin-releasing hormone agonist in the absence of exogenous gonadotropins is not sufficient to induce multiple follicle development.

PubMed

Chung, Karine; Fogle, Robin; Bendikson, Kristin; Christenson, Kamilee; Paulson, Richard

2011-01-01

Because the effectiveness of the "microdose flare" stimulation protocol often is attributed to the dramatic endogenous gonadotropin release induced by the GnRH agonist, the aim of this study was to determine whether use of microdose GnRH agonist alone could induce multiple ovarian follicle development in normal responders. Based on these data, the duration of gonadotropin rise is approximately 24 to 48 hours and is too brief to sustain continued multiple follicle growth. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

The advisability of high-rise construction in the city

NASA Astrophysics Data System (ADS)

Sergievskaya, Natalia; Pokrovskaya, Tatyana; Vorontsova, Natalya

2018-03-01

In this article there discusses the question of advisability high-rise construction, the reasons for its use, both positive and negative sides of it. On the one hand, a number of authors believe that it is difficult to avoid high-rise construction due to the limited areas in very large cities. On the other hand, a number of other authors draw attention to the problems associated with high-rise construction. The author of the article analyses examples of high-rise construction in several countries (UAE, Dubai "Burj Khalifa"; Japan "Tokyo Sky Tree"; United States of America, "Willis Tower"; Russia "Federation Tower") and proves the advisability of high-rise construction in the city.

Effects of portland cement particle size on heat of hydration.

DOT National Transportation Integrated Search

2013-12-01

Following specification harmonization for portland cements, FDOT engineers reported signs of : deterioration in concrete elements due to temperature rise effects. One of the main factors that affect : concrete temperature rise potential is the heat g...

Implications on 1+1 D runup modeling due to time features of the earthquake source

NASA Astrophysics Data System (ADS)

Fuentes, M.; Riquelme, S.; Campos, J. A.

2017-12-01

The time characteristics of the seismic source are usually neglected in tsunami modeling, due to the difference in the time scale of both processes. Nonetheless, there are just a few analytical studies that intended to explain separately the role of the rise time and the rupture velocity. In this work, we extend an analytical 1+1D solution for the shoreline motion time series, from the static case to the dynamic case, by including both, rise time and rupture velocity. Results show that the static case correspond to a limit case of null rise time and infinite rupture velocity. Both parameters contribute in shifting the arrival time, but maximum run-up may be affected by very slow ruptures and long rise time. The analytical solution has been tested for the Nicaraguan tsunami earthquake, suggesting that the rupture was not slow enough to cause wave amplification to explain the high runup observations.

Reinventing School Finance: Falling Forward

ERIC Educational Resources Information Center

Picus, Lawrence O.; Odden, Allan R.

2011-01-01

States and school districts are facing unprecedented financial pressure due to the continued poor performance of the United States's economy. Dramatic shortfalls in funding due to reduced tax collections were held off for 2 years thanks to federal stimulus funds, but with these revenues already consumed and little likelihood of more in the near…

The Chinese Experience of Rapid Modernization: Sociocultural Changes, Psychological Consequences?

PubMed Central

Sun, Jiahong; Ryder, Andrew G.

2016-01-01

Mainland China has undergone profound changes dating back to the nineteenth century, including a contemporary period of rapid modernization that began in the 1980s. The result has been dramatic social, cultural, and economic shifts impacting the daily lives of Chinese people. In this paper, we explore the psychological implications of sociocultural transformation in China, emphasizing two central themes. First, rising individualism: findings from social and developmental psychology suggest that China’s rapid development has been accompanied by ever-increasing adherence to individualistic values. Second, rising rates of depression: findings from psychiatric epidemiology point to increasing prevalence of depression over this same time period, particularly in rural settings. We argue that links between sociocultural and psychological shifts in China can be usefully studied through a cultural psychology lens, emphasizing the mutual constitution of culture, mind, and brain. In particular, we note that the link between social change, individualism, and rising mental illness deserves careful attention. Our review suggests that shifting values and socialization practices shape emotion norms of concealment and display, with implications for depressive symptom presentation. The challenge comes with interpretation. Increasing prevalence rates of depression may indeed be a general response to the rapidity of sociocultural change, or a specific consequence of rising individualism—but may also result from increasingly ‘Western’ patterns of symptom presentation, or improvements in diagnostic practice. We conclude by considering the challenges posed to standard universal models of psychological phenomena. PMID:27092093

Cereal-Based Gluten-Free Food: How to Reconcile Nutritional and Technological Properties of Wheat Proteins with Safety for Celiac Disease Patients

PubMed Central

Lamacchia, Carmela; Camarca, Alessandra; Picascia, Stefania; Di Luccia, Aldo; Gianfrani, Carmen

2014-01-01

The gluten-free diet is, to date, the only efficacious treatment for patients with Celiac Disease. In recent years, the impressive rise of Celiac Disease incidence, dramatically prompted changes in the dietary habit of an increasingly large population, with a rise in demand of gluten-free products. The formulation of gluten-free bakery products presents a formidable challenge to cereal technologists. As wheat gluten contributes to the formation of a strong protein network, that confers visco-elasticity to the dough and allows the wheat flour to be processed into a wide range of products, the preparation of cereal-based gluten-free products is a somehow difficult process. This review focuses on nutritional and technological quality of products made with gluten-free cereals available on the market. The possibility of using flour from naturally low toxic ancient wheat species or detoxified wheat for the diet of celiacs is also discussed. PMID:24481131

Long-term climate and competition explain forest mortality patterns under extreme drought.

PubMed

Young, Derek J N; Stevens, Jens T; Earles, J Mason; Moore, Jeffrey; Ellis, Adam; Jirka, Amy L; Latimer, Andrew M

2017-01-01

Rising temperatures are amplifying drought-induced stress and mortality in forests globally. It remains uncertain, however, whether tree mortality across drought-stricken landscapes will be concentrated in particular climatic and competitive environments. We investigated the effects of long-term average climate [i.e. 35-year mean annual climatic water deficit (CWD)] and competition (i.e. tree basal area) on tree mortality patterns, using extensive aerial mortality surveys conducted throughout the forests of California during a 4-year statewide extreme drought lasting from 2012 to 2015. During this period, tree mortality increased by an order of magnitude, typically from tens to hundreds of dead trees per km 2 , rising dramatically during the fourth year of drought. Mortality rates increased independently with average CWD and with basal area, and they increased disproportionately in areas that were both dry and dense. These results can assist forest managers and policy-makers in identifying the most drought-vulnerable forests across broad geographic areas. © 2016 John Wiley & Sons Ltd/CNRS.

Europa Rising

NASA Technical Reports Server (NTRS)

2007-01-01

New Horizons took this image of the icy moon Europa rising above Jupiter's cloud tops with its Long Range Reconnaissance Imager (LORRI) at 11:48 Universal Time on February 28, 2007, six hours after the spacecraft's closest approach to Jupiter.

The picture was one of a handful of the Jupiter system that New Horizons took primarily for artistic, rather than scientific, value. This particular scene was suggested by space enthusiast Richard Hendricks of Austin, Texas, in response to an Internet request by New Horizons scientists for evocative, artistic imaging opportunities at Jupiter.

The spacecraft was 2.3 million kilometers (1.4 million miles) from Jupiter and 3 million kilometers (1.8 million miles) from Europa when the picture was taken. Europa's diameter is 3,120 kilometers (1,939 miles). The image is centered on Europa coordinates 5 degrees south, 6 degrees west. In keeping with its artistic intent - and to provide a more dramatic perspective - the image has been rotated so south is at the top.

Volcanic Eruptions on Io

NASA Technical Reports Server (NTRS)

1979-01-01

This dramatic view of Jupiter's satellite Io shows two simultaneously occurring volcanic eruptions. One can be seen on the limb, (at lower right) in which ash clouds are rising more than 150 miles (260 kilometers) above the satellite's surface. The second can be seen on the terminator (shadow between day and night) where the volcanic cloud is catching the rays of the rising sun. The dark hemisphere of Io is made visible by light reflected from Jupiter. Seen in Io's night sky, Jupiter looms almost 40 times larger and 200 times brighter than our own full Moon. This photo was taken by Voyager 1 on March 8, 1979, looking back 2.6 million miles (4.5 million kilometers) at Io, three days after its historic encounter. This is the same image in which Linda A. Morabito, a JPL engineer, discovered the first extraterrestrial volcanic eruption (the bright curved volcanic cloud on the limb). Jet Propulsion Laboratory manages and controls the Voyager project for NASA's Office of Space Science.

Medical malpractice in perspective. I--The American experience.

PubMed Central

Quam, L; Dingwall, R; Fenn, P

1987-01-01

Concern over the possibility of an American style medical malpractice "crisis" in the United Kingdom has recently been voiced by members of both medical and legal professions. The validity of such fears is examined by reviewing the conditions that have given rise to the current American difficulties. It is argued that the rise in malpractice insurance premiums and associated restrictions in availability should be seen against the background of underwriting problems specific to medical liability in conjunction with a general decline in reinsurance cover. The evidence in relation to the clinical and resource implications of malpractice is analysed. In particular, arguments that increased litigation has influenced the practice of "defensive" medicine and the choice of specialty are critically examined. Medical malpractice claims and insurance are only part of a professional environment which is undergoing dramatic social and economic changes, many of which seem more plausible candidates to be treated as important influences on the nature and organisation of health care in the United States. Images p1532-a PMID:3111624

Mass and volume contributions to twentieth-century global sea level rise.

PubMed

Miller, Laury; Douglas, Bruce C

2004-03-25

The rate of twentieth-century global sea level rise and its causes are the subjects of intense controversy. Most direct estimates from tide gauges give 1.5-2.0 mm yr(-1), whereas indirect estimates based on the two processes responsible for global sea level rise, namely mass and volume change, fall far below this range. Estimates of the volume increase due to ocean warming give a rate of about 0.5 mm yr(-1) (ref. 8) and the rate due to mass increase, primarily from the melting of continental ice, is thought to be even smaller. Therefore, either the tide gauge estimates are too high, as has been suggested recently, or one (or both) of the mass and volume estimates is too low. Here we present an analysis of sea level measurements at tide gauges combined with observations of temperature and salinity in the Pacific and Atlantic oceans close to the gauges. We find that gauge-determined rates of sea level rise, which encompass both mass and volume changes, are two to three times higher than the rates due to volume change derived from temperature and salinity data. Our analysis supports earlier studies that put the twentieth-century rate in the 1.5-2.0 mm yr(-1) range, but more importantly it suggests that mass increase plays a larger role than ocean warming in twentieth-century global sea level rise.

Partial protection from organophosphate-induced cholinesterase inhibition by metyrapone treatment.

PubMed

Swiercz, Radosław; Lutz, Piotr; Gralewicz, Sławomir; Grzelińska, Zofia; Piasecka-Zelga, Joanna; Wąsowicz, Wojciech

2013-08-01

Organophosphates are cholinesterase (ChE) inhibitors with worldwide use as insecticides. Stress response, evidenced by a dramatic and relatively long-lasting (several hours) rise in the plasma glucocorticoid concentration is an integral element of the organophosphate (OP) poisoning symptomatology. In rodents, corticosterone (CORT) is the main glucocorticoid. There are several reports suggesting a relationship between the stressor-induced rise in CORT concentration (the CORT response) and the activity of the cerebral and peripheral ChE. Thus, it seems reasonable to presume that, in OP intoxication, the rise in plasma CORT concentration may somehow affect the magnitude of the OP-induced ChE inhibition. Metyrapone (MET) [2-methyl-1,2-di(pyridin-3-yl)propan-1-one] blocks CORT synthesis by inhibiting steroid 11β-hydroxylase, thereby preventing the CORT response. Chlorfenvinphos (CVP) [2-chloro-1-(2,4-dichlorophenyl) ethenyl diethyl phosphate] is an organophosphate insecticide still in use in some countries. The purpose of the present work was to compare the CVP-induced effects - the rise of the plasma CORT concentration and the reduction in ChE activity - in MET-treated and MET-untreated rats. Chlorfenvinphos was administered once at 0.0, 0.5, 1.0 and 3.0 mg/kg i.p. Metyrapone, at 100 mg/kg i.p., was administered five times, at 24-h intervals. The first MET dose was given two hours before CVP. The following was observed in the MET-treated rats: i) no rise in plasma CORT concentration after the CVP administration, ii) a reduced inhibition and a faster restitution of blood and brain ChE activities. The results suggest that MET treatment may confer significant protection against at least some effects of OP poisoning. The likely mechanism of the protective MET action has been discussed.

The Wadden Sea in transition - consequences of sea level rise

NASA Astrophysics Data System (ADS)

Becherer, Johannes; Hofstede, Jacobus; Gräwe, Ulf; Purkiani, Kaveh; Schulz, Elisabeth; Burchard, Hans

2018-01-01

The impact of sea level rise (SLR) on the future morphological development of the Wadden Sea (North Sea) is investigated by means of extensive process-resolving numerical simulations. A new sediment and morphodynamic module was implemented in the well-established 3D circulation model GETM. A number of different validations are presented, ranging from an idealized 1D channel over a semi-idealized 2D Wadden Sea basin to a fully coupled realistic 40-year hindcast without morphological amplification of the Sylt-Rømøbight, a semi-enclosed subsystem of the Wadden Sea. Based on the results of the hindcast, four distinct future scenarios covering the period 2010-2100 are simulated. While these scenarios differ in the strength of SLR and wind forcing, they also account for an expected increase of tidal range over the coming century. The results of the future projections indicate a transition from a tidal-flat-dominated system toward a lagoon-like system, in which large fractions of the Sylt-Rømøbight will remain permanently covered by water. This has potentially dramatic implications for the unique ecosystem of the Wadden Sea. Although the simulations also predict an increased accumulation of sediment in the back-barrier basin, this accumulation is far too weak to compensate for the rise in mean sea level.

Infrastructure effects on estuarine wetlands increase their vulnerability to sea level rise

NASA Astrophysics Data System (ADS)

Rodriguez, Jose; Saco, Patricia; Sandi, Steven; Saintilan, Neil; Riccardi, Gerardo

2017-04-01

At the regional and global scales, coastal management and planning for future sea level rise scenarios is typically supported by modelling tools that predict the expected inundation extent. These tools rely on a number of simplifying assumptions that, in some cases, may result in important miscalculation of the inundation effects. One of such cases is estuarine wetlands, where vegetation strongly depends on both the magnitude and the timing of inundation. Many coastal wetlands display flow restrictions due to infrastructure or drainage works, which produce alterations to the inundation patterns that can not be captured by conventional models. In this contribution we explore the effects of flow restrictions on inundation patterns under sea level rise conditions in estuarine wetlands. We use a spatially-distributed dynamic wetland ecogeomorphological model that not only incorporates the effects of flow restrictions due to culverts, bridges and weirs as well as vegetation, but also considers that vegetation changes as a consequence of increasing inundation. We also consider the ability of vegetation to capture sediment and produce accretion. We apply our model to an estuarine wetland in Australia and show that our model predicts a much faster wetland loss due to sea level rise than conventional approaches.

Geologic effects and coastal vulnerability to sea-level rise, erosion, and storms

USGS Publications Warehouse

Williams, S.J.; Gutierrez, B.T.; Thieler, E.R.; Pendleton, E.

2008-01-01

A combination of natural and human factors are driving coastal change and making coastal regions and populations increasingly vulnerable. Sea level, a major agent of coastal erosion, has varied greatly from -120 m below present during glacial period low-stands to + 4 to 6 m above present during interglacial warm periods. Geologic and tide gauge data show that global sea level has risen about 12 to 15 cm during the past century with satellite measurements indicating an acceleration since the early 1990s due to thermal expansion and ice-sheet melting. Land subsidence due to tectonic forces and sediment compaction in regions like the mid-Atlantic and Louisiana increase the rate of relative sea-level rise to 40 cm to 100 cm per century. Sea- level rise is predicted to accelerate significantly in the near future due to climate change, resulting in pervasive impacts to coastal regions and putting populations increasingly at risk. The full implications of climate change for coastal systems need to be understood better and long-term plans are needed to manage coasts in order to protect natural resources and mitigate the effects of sea-level rise and increased storms on human infrastructure. 

Lessons from the war on dietary fat.

PubMed

Walker, Thomas B; Parker, Mary Jo

2014-01-01

Conventional dietary guidelines put forth by health care institutions and providers for the past 40 years have stressed the importance of reducing the amount of dietary fat consumed. Such a diet is purported to mitigate metabolic risk factors and optimize the ability to achieve or maintain a healthy body weight. However, over the past 35 years obesity rates in the United States have risen dramatically though the level of dietary fat consumed by U.S. adults has fallen. This review examines the potential reasons for this paradox. Various meta-analyses, controlled trials, and cohort studies have demonstrated that reducing dietary fat intake provides for very little weight loss unless accompanied by equal or greater reductions in total energy intake. Due to both psychological (e.g., the tendency for people to eat more of what they consider low fat) and physiological (e.g., the low satiety that accompanies carbohydrate intake) factors, reducing total caloric intake while simultaneously reducing fat intake is a difficult challenge. Further, reductions in total carbohydrate intake, increases in protein intake, and adoption of a Mediterranean diet seem to be more effective in inducing weight loss than reductions in fat intake. Traditional claims that simply reducing dietary fat will improve metabolic risk factors are also not borne out by research. There is some evidence that replacing dietary saturated fat with unsaturated fat may improve metabolic risk factors, but that research is not conclusive. • Over the past 40 years, Americans have decreased the percentage of calories they get from dietary fat while rates of overweight and obesity have risen dramatically. • It appears that a decrease in total dietary fat in ad libitum diets may induce a very small decrease in body weight. • Evidence suggests that reductions in total dietary fat intake often occur in conjunction with an increase in total caloric intake. • It seems reasonable to conclude that guiding the public to simply reduce dietary fat intake is an ineffective method to mitigate the rise in obesity and improve public health.

Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka.

PubMed

Nanayakkara, Shanika; Komiya, Toshiyuki; Ratnatunga, Neelakanthi; Senevirathna, S T M L D; Harada, Kouji H; Hitomi, Toshiaki; Gobe, Glenda; Muso, Eri; Abeysekera, Tilak; Koizumi, Akio

2012-05-01

Chronic kidney disease of uncertain etiology (CKDu) in North Central Province of Sri Lanka has become a key public health concern in the agricultural sector due to the dramatic rise in its prevalence and mortality among young farmers. Although cadmium has been suspected as a causative pathogen, there have been controversies. To date, the pathological characteristics of the disease have not been reported. Histopathological observations of 64 renal biopsies obtained at Anuradhapura General Hospital from October 2008 to July 2009 were scored according to Banff 97 Working Classification of Renal Allograft pathology. The correlations between the histological observations and clinical parameters were statistically analyzed. Interstitial fibrosis and tubular atrophy with or without nonspecific interstitial mononuclear cell infiltration was the dominant histopathological observation. Glomerular sclerosis, glomerular collapse, and features of vascular pathology such as fibrous intimal thickening and arteriolar hyalinosis were also common. Although hypertension was identified as one of the common clinical features among the cases, it did not influence the histopathological lesions in all the cases. This study concludes that tubulointerstitial damage is the major pathological lesion in CKDu. Exposure(s) to an environmental pathogen(s) should be systematically investigated to elucidate such tubulointerstitial damage in CKDu.

Determination of Realistic Fire Scenarios in Spacecraft

NASA Technical Reports Server (NTRS)

Dietrich, Daniel L.; Ruff, Gary A.; Urban, David

2013-01-01

This paper expands on previous work that examined how large a fire a crew member could successfully survive and extinguish in the confines of a spacecraft. The hazards to the crew and equipment during an accidental fire include excessive pressure rise resulting in a catastrophic rupture of the vehicle skin, excessive temperatures that burn or incapacitate the crew (due to hyperthermia), carbon dioxide build-up or accumulation of other combustion products (e.g. carbon monoxide). The previous work introduced a simplified model that treated the fire primarily as a source of heat and combustion products and sink for oxygen prescribed (input to the model) based on terrestrial standards. The model further treated the spacecraft as a closed system with no capability to vent to the vacuum of space. The model in the present work extends this analysis to more realistically treat the pressure relief system(s) of the spacecraft, include more combustion products (e.g. HF) in the analysis and attempt to predict the fire spread and limiting fire size (based on knowledge of terrestrial fires and the known characteristics of microgravity fires) rather than prescribe them in the analysis. Including the characteristics of vehicle pressure relief systems has a dramatic mitigating effect by eliminating vehicle overpressure for all but very large fires and reducing average gas-phase temperatures.

Effects of wake and shock passing on the heat transfer to a film cooled transonic turbine blade

NASA Astrophysics Data System (ADS)

Rigby, M. J.

An attempt is made to further the understanding of film cooling process in an engine environment. The environment in a gas turbine is unsteady. A source of unsteadiness, the cutting of nozzle guide vane (NGV) wakes and shock waves by the rotor, was modeled experimentally. The influence of the unsteady wakes and shock waves on the heat transfer to a film cooled rotor blade was studied for five film cooling configurations using a rotating bar apparatus in front of a 2-D cascade. Heat transfer measurements were made using thin film gauges placed at the mid-span of the test blade. Schlieren photography was used to study the behavior of the coolant film and the movement of the unsteady shock waves and wakes. The effect of simulated NGV wake passing observed on the uncooled airfoil is to promote an intermittent transition of the suction surface. The effect of the wake on the turbulent pressure surface is small. With injection on the suction surface, the film acts as a boundary layer trip which offsets the rise in heat transfer due to the wake. The simulated NGV trailing edge shock wave had a dramatic effect on the suction surface heat transfer.

Climate Change and Its Impact on the Eco-Environment of the Three-Rivers Headwater Region on the Tibetan Plateau, China.

PubMed

Jiang, Chong; Zhang, Linbo

2015-09-25

This study analyzes the impact of climate change on the eco-environment of the Three-Rivers Headwater Region (TRHR), Tibetan Plateau, China. Temperature and precipitation experienced sharp increases in this region during the past 57 years. A dramatic increase in winter temperatures contributed to a rise in average annual temperatures. Moreover, annual runoff in the Lancang (LRB) and Yangtze (YARB) river basins showed an increasing trend, compared to a slight decrease in the Yellow River Basin (YRB). Runoff is predominantly influenced by rainfall, which is controlled by several monsoon systems. The water temperature in the YRB and YARB increased significantly from 1958 to 2007 (p < 0.001), driven by air temperature changes. Additionally, owing to warming and wetting trends in the TRHR, the net primary productivity (NPP) and normalized difference vegetation index (NDVI) showed significant increasing trends during the past half-century. Furthermore, although an increase in water erosion due to rainfall erosivity was observed, wind speeds declined significantly, causing a decline in wind erosion, as well as the frequency and duration of sandstorms. A clear regional warming trend caused an obvious increasing trend in glacier runoff, with a maximum value observed in the 2000s.

Effects of flow regime on metal concentrations and the attainment of water quality standards in a remediated stream reach, Butte, Montana

USGS Publications Warehouse

Runkel, Robert L.; Kimball, Briant A.; Nimick, David A.; Walton-Day, Katherine

2016-01-01

Low-flow synoptic sampling campaigns are often used as the primary tool to characterize watersheds affected by mining. Although such campaigns are an invaluable part of site characterization, investigations which focus solely on low-flow conditions may yield misleading results. The objective of this paper is to demonstrate this point and elucidate the mechanisms responsible for the release of metals during rainfall runoff. This objective is addressed using data from diel and synoptic sampling campaigns conducted over a two-day period. Low-flow synoptic sampling results indicate that concentrations of most constituents meet aquatic standards. This finding is in contrast to findings from a diel sampling campaign that captured dramatic increases in concentrations during rainfall runoff. Concentrations during the rising limb of the hydrograph were 2–23 times concentrations observed during synoptic sampling (most increases were >10-fold), remaining elevated during the receding limb of the hydrograph to produce a clockwise hysteresis loop. Hydrologic mechanisms responsible for the release of metals include increased transport due to resuspension of streambed solids, erosion of alluvial tailings, and overland flow. Rainfall also elevated the alluvial groundwater table and increased infiltration through the vadose zone, likely resulting in dissolution from alluvial tailings that were dry prior to the event.

Local cellular neighborhood controls proliferation in cell competition

PubMed Central

Bove, Anna; Gradeci, Daniel; Fujita, Yasuyuki; Banerjee, Shiladitya; Charras, Guillaume; Lowe, Alan R.

2017-01-01

Cell competition is a quality-control mechanism through which tissues eliminate unfit cells. Cell competition can result from short-range biochemical inductions or long-range mechanical cues. However, little is known about how cell-scale interactions give rise to population shifts in tissues, due to the lack of experimental and computational tools to efficiently characterize interactions at the single-cell level. Here, we address these challenges by combining long-term automated microscopy with deep-learning image analysis to decipher how single-cell behavior determines tissue makeup during competition. Using our high-throughput analysis pipeline, we show that competitive interactions between MDCK wild-type cells and cells depleted of the polarity protein scribble are governed by differential sensitivity to local density and the cell type of each cell’s neighbors. We find that local density has a dramatic effect on the rate of division and apoptosis under competitive conditions. Strikingly, our analysis reveals that proliferation of the winner cells is up-regulated in neighborhoods mostly populated by loser cells. These data suggest that tissue-scale population shifts are strongly affected by cellular-scale tissue organization. We present a quantitative mathematical model that demonstrates the effect of neighbor cell–type dependence of apoptosis and division in determining the fitness of competing cell lines. PMID:28931601

Diet, growth, and obesity development throughout childhood in the Avon Longitudinal Study of Parents and Children.

PubMed

Emmett, Pauline M; Jones, Louise R

2015-10-01

Publications from the Avon Longitudinal Study of Parents and Children covering diet, growth, and obesity development during childhood are reviewed. Diet was assessed by food frequency questionnaires and food records. Growth data were collected by routine measurements, and in standardized clinics, body fatness was assessed by bioelectrical impedance and DXA (dual-energy X-ray absorptiometry) scans. Diets changed dramatically during the preschool period with an increase in the intake of free (added) sugars (12.3% rising to 16.4% of energy) that remained similar until adolescence. This was due to increased intake of energy-dense, nutrient-poor foods. Two periods of rapid growth were identified; infancy and mid-childhood (ages 7-11 y) and both were associated with obesity development. Diets with high energy density were associated with increasing fat mass from mid-childhood until adolescence. Genetic and dietary factors showed independent associations with increasing adiposity. At all ages studied, there were dietary inequalities related to maternal educational attainment that may influence inequalities found in obesity development. The Avon Longitudinal Study of Parents and Children has provided valuable insights into how disparities in diet and growth may affect the development of ill health in adulthood. © The Author(s) 2015. Published by Oxford University Press on behalf of the International Life Sciences Institute.

Climate Change and Its Impact on the Eco-Environment of the Three-Rivers Headwater Region on the Tibetan Plateau, China

PubMed Central

Jiang, Chong; Zhang, Linbo

2015-01-01

This study analyzes the impact of climate change on the eco-environment of the Three-Rivers Headwater Region (TRHR), Tibetan Plateau, China. Temperature and precipitation experienced sharp increases in this region during the past 57 years. A dramatic increase in winter temperatures contributed to a rise in average annual temperatures. Moreover, annual runoff in the Lancang (LRB) and Yangtze (YARB) river basins showed an increasing trend, compared to a slight decrease in the Yellow River Basin (YRB). Runoff is predominantly influenced by rainfall, which is controlled by several monsoon systems. The water temperature in the YRB and YARB increased significantly from 1958 to 2007 (p < 0.001), driven by air temperature changes. Additionally, owing to warming and wetting trends in the TRHR, the net primary productivity (NPP) and normalized difference vegetation index (NDVI) showed significant increasing trends during the past half-century. Furthermore, although an increase in water erosion due to rainfall erosivity was observed, wind speeds declined significantly, causing a decline in wind erosion, as well as the frequency and duration of sandstorms. A clear regional warming trend caused an obvious increasing trend in glacier runoff, with a maximum value observed in the 2000s. PMID:26404333

Dramatic Enhancement in Photoresponse of β-In2S3 through Suppression of Dark Conductivity by Synthetic Control of Defect-Induced Carrier Compensation.

PubMed

Chaudhari, Nilima; Mandal, Lily; Game, Onkar; Warule, Sambhaji; Phase, Deodatta; Jadkar, Sandesh; Ogale, Satishchandra

2015-08-19

We report on the synthesis of dense and faceted indium sulfide (β-In2S3) nano-octahedron films on fluorine-doped tin oxide-coated glass by the hydrothermal method and their photoresponse properties in a flip chip device configuration. We have examined the temporal evolution of the phase constitution, morphology, and optoelectronic properties for films obtained after growth interruption at specific intervals. It is noted that, initially, an In(OH)3 film forms, which is gradually transformed to the β-In2S3 phase over time. In the case of the film wherein most, but not all, of In(OH)3 is consumed, an exceptionally large photoresponse (light to dark current ratio) of ∼10(4) and response time(s) (rise/fall) of ∼88/280 ms are realized. This superior performance is attributed to nearly complete carrier compensation achievable in the system under high pressure growth leading to dramatic reduction of dark conductivity. It is argued that the temporally growth-controlled equilibrium between quasi-In interstitials and cation vacancies dictates the optoelectronic properties.

The rising level of medical student debt: potential risk for a national default.

PubMed

Ariyan, S

2000-04-01

At the turn of the 20th century, mostly as a result of the Flexner report, medical education changed dramatically by establishing a scientific basis for the study of medicine within the institutions of the major universities. There have been major and dramatic changes in medicine during the past 80 years that have improved medical education in the United States, but these changes have also placed major economic strains on students who have educational debts. If medicine is a social responsibility to the public, then the public should share the responsibility of identifying and supporting new approaches to funding and financially managing the teaching of future physicians. There is no universal solution because there are various approaches institutions may take to structure these financial responsibilities. This article describes trends in medical student educational debt, identifies the financial needs of medical students, and proposes ways of addressing those needs to avert a possible national financial crisis among medical students. We must invest in medical students because they will be the leaders we need to help care for our society and our own families in the next century.

Cavitation and radicals drive the sonochemical synthesis of functional polymer spheres

DOE PAGES

Narayanan, Badri; Deshmukh, Sanket A.; Shrestha, Lok Kumar; ...

2016-07-25

Sonochemical synthesis can lead to a dramatic increase in the kinetics of formation of polymer spheres (templates for carbon spheres) compared to the modified Stober silica method applied to produce analogous polymer spheres. Reactive molecular dynamics simulations of the sonochemical process indicate a significantly enhanced rate of polymer sphere formation starting from resorcinol and formaldehyde precursors. The associated chemical reaction kinetics enhancement due to sonication is postulated to arise from the localized lowering of atomic densities, localized heating, and generation of radicals due to cavitation collapse in aqueous systems. This dramatic increase in reaction rates translates into enhanced nucleation andmore » growth of the polymer spheres. Finally, the results are of broad significance to understanding mechanisms of sonication induced synthesis as well as technologies utilizing polymers spheres.« less

Cavitation and radicals drive the sonochemical synthesis of functional polymer spheres

DOE Office of Scientific and Technical Information (OSTI.GOV)

Narayanan, Badri, E-mail: bnarayanan@anl.gov; Deshmukh, Sanket A.; Sankaranarayanan, Subramanian K. R. S., E-mail: ssankaranarayanan@anl.gov

2016-07-25

Sonochemical synthesis can lead to a dramatic increase in the kinetics of formation of polymer spheres (templates for carbon spheres) compared to the modified Stöber silica method applied to produce analogous polymer spheres. Reactive molecular dynamics simulations of the sonochemical process indicate a significantly enhanced rate of polymer sphere formation starting from resorcinol and formaldehyde precursors. The associated chemical reaction kinetics enhancement due to sonication is postulated to arise from the localized lowering of atomic densities, localized heating, and generation of radicals due to cavitation collapse in aqueous systems. This dramatic increase in reaction rates translates into enhanced nucleation andmore » growth of the polymer spheres. The results are of broad significance to understanding mechanisms of sonication induced synthesis as well as technologies utilizing polymers spheres.« less

A method of estimating ground-water supplies based on discharge by plants and evaporation from soil: Results of investigations in Escalante Valley, Utah

USGS Publications Warehouse

White, W.N.

1932-01-01

Fluctuations of water levels in wells, if critically studied, may give much information as to the occurrence, movement, and quantity of available ground water. In some localities the ground-water level has been observed to decline during the day and to rise at night, the decline beginning at about the same hour every morning and the rise at about the same hour every night. This daily decline is due to the withdrawal of ground water from the zone of saturation by plants, and the rise at night is due to upward movement of water under slight artesian pressure from permeable beds of sand and gravel at some depth beneath the water table.

Using Groundwater Modeling to Evaluate Impacts of Sea Level Rise on A Coastal Riverine Ecosystem: A Case Study of Saint Jones River Water Shed

NASA Astrophysics Data System (ADS)

He, C.; McKenna, T. E.

2016-12-01

A 3-D, transient, variable-density groundwater flow model (SEAWAT) is used to simulate the groundwater response to predicted sea level rise in the Saint Jones River watershed adjacent to the Delaware Estuary. Sea level rise directly leads to substantial changes in the depth of water table, and these changes can extend far inland due to the long tidal rivers in this area. This research studied the impacts of three different sea level rise scenarios (0.5m, 1.0m and 1.5m) on two concerned aspects in the area: failure of septic tank system and loss of agriculture land. The model results indicate that 1) 10% 13% of current existing septic tank will fail as the water table rise to less than 1.5meters from land surface, and 2) approximate 271 to 927 acres of agriculture land, which covers about 4% 13% of total current agriculture land in the study area, will be lost due to water table rise above the effective rooting depth. To count in the uncertainty of climate change in the future, Monte Carlo simulation was applied and a linear transformation model was created and verified to facilitate the tremendous computation.

Temporal trend analysis of avoidable mortality in Taiwan, 1971-2008: overall progress, with areas for further medical or public health investment

PubMed Central

2013-01-01

Background Avoidable mortality (AM), or “unnecessary untimely death,” is considered an indicator of health care quality. We investigated trends in the age-standardized mortality rates (ASMRs) and associated standard expected years of life lost (SEYLL) for deaths amenable to medical care or public health measures in Taiwan from 1971-2008, with an emphasis on identifying areas where additional medical or public health investment may help reduce the burden of AM. Methods Taiwan’s ASMRs per 100,000 for AM and other causes of death were calculated using data from the National Death Certificate Registry in five-year bins from 1971 to 2008. SEYLL rates per 100,000 were calculated annually from 1971 to 2008 using the same data source. Results ASMR for almost all AM and other causes of death declined dramatically from 1971 to 2008 except for lung cancer (16.6% and 7.4% increase among men and women, respectively) and breast cancer (109.8% increase among women). In the same period, SEYLL due to lung cancer increased from 269.2 to 555.7 for men and 249.7 to 342.5 for women. For women, SEYLL due to breast cancer increased from 263.5 in 1971 to 659.3 in 2008. There were gender-specific differences in the reduction (or increase) in AM rates, with women showing larger rates of reduction or smaller rates of increase. Among men, AM fell by 65.9% from 1971-1975 to 2006-2008, and deaths from other causes increased by 15.6%. Among women, AM and deaths from other causes fell by 80.8% and 59.8% respectively. SEYLL decreased, respectively among males and females, from 23,147.3 and 24,081.1 in 1971 to 11,261.8 and 5,929.6 in 2008. Conclusion From 1971 to 2008, Taiwan experienced a dramatic reduction in most AM and corresponding SEYLL except for lung cancer (for both males and females) and breast cancer (for females). Additional effort should be devoted to public health measures to combat the rising prevalence of smoking in Taiwan, which may be responsible for the increasing AM from lung cancer. If AM in breast cancer continues unabated in the future, greater policy emphasis on the early detection and treatment of breast cancer may also be warranted. PMID:23742049

Temporal trend analysis of avoidable mortality in Taiwan, 1971-2008: overall progress, with areas for further medical or public health investment.

PubMed

Chen, Brian K; Yang, Chun-Yuh

2013-06-06

Avoidable mortality (AM), or "unnecessary untimely death," is considered an indicator of health care quality. We investigated trends in the age-standardized mortality rates (ASMRs) and associated standard expected years of life lost (SEYLL) for deaths amenable to medical care or public health measures in Taiwan from 1971-2008, with an emphasis on identifying areas where additional medical or public health investment may help reduce the burden of AM. Taiwan's ASMRs per 100,000 for AM and other causes of death were calculated using data from the National Death Certificate Registry in five-year bins from 1971 to 2008. SEYLL rates per 100,000 were calculated annually from 1971 to 2008 using the same data source. ASMR for almost all AM and other causes of death declined dramatically from 1971 to 2008 except for lung cancer (16.6% and 7.4% increase among men and women, respectively) and breast cancer (109.8% increase among women). In the same period, SEYLL due to lung cancer increased from 269.2 to 555.7 for men and 249.7 to 342.5 for women. For women, SEYLL due to breast cancer increased from 263.5 in 1971 to 659.3 in 2008. There were gender-specific differences in the reduction (or increase) in AM rates, with women showing larger rates of reduction or smaller rates of increase. Among men, AM fell by 65.9% from 1971-1975 to 2006-2008, and deaths from other causes increased by 15.6%. Among women, AM and deaths from other causes fell by 80.8% and 59.8% respectively. SEYLL decreased, respectively among males and females, from 23,147.3 and 24,081.1 in 1971 to 11,261.8 and 5,929.6 in 2008. From 1971 to 2008, Taiwan experienced a dramatic reduction in most AM and corresponding SEYLL except for lung cancer (for both males and females) and breast cancer (for females). Additional effort should be devoted to public health measures to combat the rising prevalence of smoking in Taiwan, which may be responsible for the increasing AM from lung cancer. If AM in breast cancer continues unabated in the future, greater policy emphasis on the early detection and treatment of breast cancer may also be warranted.

Concise Review: Kidney Stem/Progenitor Cells: Differentiate, Sort Out, or Reprogram?

PubMed Central

Pleniceanu, Oren; Harari-Steinberg, Orit; Dekel, Benjamin

2010-01-01

End-stage renal disease (ESRD) is defined as the inability of the kidneys to remove waste products and excess fluid from the blood. ESRD progresses from earlier stages of chronic kidney disease (CKD) and occurs when the glomerular filtration rate (GFR) is below 15 ml/minute/1.73 m2. CKD and ESRD are dramatically rising due to increasing aging population, population demographics, and the growing rate of diabetes and hypertension. Identification of multipotential stem/progenitor populations in mammalian tissues is important for therapeutic applications and for understanding developmental processes and tissue homeostasis. Progenitor populations are ideal targets for gene therapy, cell transplantation, and tissue engineering. The demand for kidney progenitors is increasing due to severe shortage of donor organs. Because dialysis and transplantation are currently the only successful therapies for ESRD, cell therapy offers an alternative approach for kidney diseases. However, this approach may be relevant only in earlier stages of CKD, when kidney function and histology are still preserved, allowing for the integration of cells and/or for their paracrine effects, but not when small and fibrotic end-stage kidneys develop. Although blood- and bone marrow-derived stem cells hold a therapeutic promise, they are devoid of nephrogenic potential, emphasizing the need to seek kidney stem cells beyond known extrarenal sources. Moreover, controversies regarding the existence of a true adult kidney stem cell highlight the importance of studying cell-based therapies using pluripotent cells, progenitor cells from fetal kidney, or dedifferentiated/reprogrammed adult kidney cells. Stem Cells 2010; 28:1649–1660. PMID:20652959

Speleothem records of acid sulphate deposition and organic carbon mobilisation

NASA Astrophysics Data System (ADS)

Wynn, Peter; Fairchild, Ian; Bourdin, Clement; Baldini, James; Muller, Wolfgang; Hartland, Adam; Bartlett, Rebecca

2017-04-01

Dramatic increases in measured surface water DOC in recent decades have been variously attributed to either temperature rise, or destabilisation of long-term soil carbon pools following sulphur peak emissions status. However, whilst both drivers of DOC dynamics are plausible, they remain difficult to test due to the restricted nature of the available records of riverine DOC flux (1978 to present), and the limited availability of SO2 emissions inventory data at the regional scale. Speleothems offer long term records of both sulphur and carbon. New techniques to extract sulphur concentrations and isotopes from speleothem calcite have enabled archives of pollution history and environmental acidification to be reconstructed. Due to the large dynamic range in sulphur isotopic values from end member sources (marine aerosol +21 ‰ to continental biogenic emissions -30 ‰) and limited environmental fractionation under oxidising conditions, sulphur isotopes form an ideal tracer of industrial pollution and environmental acidification in the palaeo-record. We couple this acidification history to the carbon record, using organic matter fluorescence and trace metals. Trace metal ratios and abundance can be used to infer the type and size of organic ligand and are therefore sensitive to changes in temperature as a driver of organic carbon processing and biodegradation. This allows fluorescent properties and ratios of trace metals in speleothem carbonate to be used to represent both the flux of organic carbon into the cave as well as the degradation pathway. Here we present some of the first results of this work, exploring sulphur acidification as a mechanistic control on carbon solubility and export throughout the twentieth century.

The Optical Variability of SDSS Quasars from Multi-epoch Spectroscopy. III. A Sudden UV Cutoff in Quasar SDSS J2317+0005

NASA Astrophysics Data System (ADS)

Guo, Hengxiao; Malkan, Matthew A.; Gu, Minfeng; Li, Linlin; Prochaska, J. Xavier; Ma, Jingzhe; You, Bei; Zafar, Tayyaba; Liao, Mai

2016-08-01

We have collected near-infrared to X-ray data of 20 multi-epoch heavily reddened SDSS quasars to investigate the physical mechanism of reddening. Of these, J2317+0005 is found to be a UV cutoff quasar. Its continuum, which usually appears normal, decreases by a factor 3.5 at 3000 Å, compared to its more typical bright state during an interval of 23 days. During this sudden continuum cut-off the broad emission line fluxes do not change, perhaps due to the large size of the broad-line region (BLR), r \\gt 23/(1+z) days. The UV continuum may have suffered a dramatic drop out. However, there are some difficulties with this explanation. Another possibility is that the intrinsic continuum did not change but was temporarily blocked out, at least toward our line of sight. As indicated by X-ray observations, the continuum rapidly recovers after 42 days. A comparison of the bright state and dim states would imply an eclipse by a dusty cloud with a reddening curve having a remarkably sharp rise shortward of 3500 Å. Under the assumption of being eclipsed by a Keplerian dusty cloud, we characterized the cloud size with our observations, however, which is a little smaller than the 3000 Å continuum-emitting size inferred from accretion disk models. Therefore, we speculate that this is due to a rapid outflow or inflow with a dusty cloud passing through our line of sight to the center.

[BIOLOGICAL EFFECTIVENESS OF FISSION SPECTRUM NEUTRONS AND PROTONS WITH ENERGIES OF 60-126 MEV DURING ACUTE AND PROLONGED IRRADIATION].

PubMed

Shafirkin, A V

2015-01-01

Neutrons of the fission spectrum are characterized by relatively high values of linear energy transfer (LET). Data about their effects on biological objects are used to evaluate the risk of delayed effects of accelerated ions within the same LET range that serve as an experimental model of the nuclei component of galactic cosmic rays (GCR). Additionally, risks of delayed consequences to cosmonaut's health and average lifetime from certain GCR fluxes and secondary neutrons can be also prognosticated. The article deals with comparative analysis of the literature on reduction of average lifespan (ALS) of animals exposed to neutron reactor spectrum, 60-126 MeV protons, and X- and γ-rays in a broad range of radiation intensity and duration. It was shown that a minimal lifespan reduction by 5% occurs due to a brief exposure to neutrons with the absorbed dose of 5 cGy, whereas same lifespan reduction due to hard X- and γ-radiation occurs after absorption of a minimal dose of 100 cGy. Therefore, according to the estimated minimal ALS reduction in mice, neutron effectiveness is 20-fold higher. Biological effectiveness of protons as regards ALS reduction is virtually equal to that of standard types of radiation. Exposure to X- and γ-radiation with decreasing daily doses, and increasing number of fractions and duration gives rise to an apparent trend toward a less dramatic ALS reduction in mice; on the contrary, exposure to neutrons of varying duration had no effect on threshold doses for the specified ALS reductions. Factors of relative biological effectiveness of neutrons reached 40.

Sea level rise with warming above 2 degree

NASA Astrophysics Data System (ADS)

Jevrejeva, Svetlana; Jackson, Luke; Riva, Riccardo; Grinsted, Aslak; Moore, John

2017-04-01

Holding the increase in the global average temperature to below 2 °C above pre-industrial levels, and pursuing efforts to limit the temperature increase to 1.5 °C, has been agreed by the representatives of the 196 parties of United Nations, as an appropriate threshold beyond which climate change risks become unacceptably high. Sea level rise is one of the most damaging aspects of warming climate for the more than 600 million people living in low-elevation coastal areas less than 10 meters above sea level. Fragile coastal ecosystems and increasing concentrations of population and economic activity in coastal areas, are reasons why future sea level rise is one of the most damaging aspects of the warming climate. Furthermore, sea level is set to continue to rise for centuries after greenhouse gas emissions concentrations are stabilised due to system inertia and feedback time scales. Impact, risk, adaptation policies and long-term decision making in coastal areas depend on regional and local sea level rise projections and local projections can differ substantially from the global one. Here we provide probabilistic sea level rise projections for the global coastline with warming above the 2 degree goal. A warming of 2°C makes global ocean rise on average by 20 cm, but more than 90% of coastal areas will experience greater rises, 40 cm along the Atlantic coast of North America and Norway, due to ocean dynamics. If warming continues above 2°C, then by 2100 sea level will rise with speeds unprecedented throughout human civilization, reaching 0.9 m (median), and 80% of the global coastline will exceed the global ocean sea level rise upper 95% confidence limit of 1.8 m. Coastal communities of rapidly expanding cities in the developing world, small island states, and vulnerable tropical coastal ecosystems will have a very limited time after mid-century to adapt to sea level rises.

Model development and experimental validation for analyzing initial transients of irradiation of tissues during thermal therapy using short pulse lasers.

PubMed

Ganguly, Mohit; Miller, Stephanie; Mitra, Kunal

2015-11-01

Short pulse lasers with pulse durations in the range of nanoseconds and shorter are effective in the targeted delivery of heat energy for precise tissue heating and ablation. This photothermal therapy is useful where the removal of cancerous tissue sections is required. The objective of this paper is to use finite element modeling to demonstrate the differences in the thermal response of skin tissue to short-pulse and continuous wave laser irradiation in the initial stages of the irradiation. Models have been developed to validate the temperature distribution and heat affected zone during laser irradiation of excised rat skin samples and live anesthetized mouse tissue. Excised rat skin samples and live anesthetized mice were subjected to Nd:YAG pulsed laser (1,064 nm, 500 ns) irradiation of varying powers. A thermal camera was used to measure the rise in surface temperature as a result of the laser irradiation. Histological analyses of the heat affected zone created in the tissue samples due to the temperature rise were performed. The thermal interaction of the laser with the tissue was quantified by measuring the thermal dose delivered by the laser. Finite element geometries of three-dimensional tissue sections for continuum and vascular models were developed using COMSOL Multiphysics. Blood flow was incorporated into the vascular model to mimic the presence of discrete blood vessels and contrasted with the continuum model without blood perfusion. The temperature rises predicted by the continuum and the vascular models agreed with the temperature rises observed at the surface of the excised rat tissue samples and live anesthetized mice due to laser irradiation respectively. The vascular model developed was able to predict the cooling produced by the blood vessels in the region where the vessels were present. The temperature rise in the continuum model due to pulsed laser irradiation was higher than that due to continuous wave (CW) laser irradiation in the initial stages of the irradiation. The temperature rise due to pulsed and CW laser irradiation converged as the time of irradiation increased. A similar trend was observed when comparing the thermal dose for pulsed and CW laser irradiation in the vascular model. Finite element models (continuum and vascular) were developed that can be used to predict temperature rise and quantify the thermal dose resulting from laser irradiation of excised rat skin samples and live anesthetized mouse tissue. The vascular model incorporating blood perfusion effects predicted temperature rise better in the live animal tissue. The models developed demonstrated that pulsed lasers caused greater temperature rise and delivered a greater thermal dose than CW lasers of equal average power, especially during the initial transients of irradiation. This analysis will be beneficial for thermal therapy applications where maximum delivery of thermal dose over a short period of time is important. © 2015 Wiley Periodicals, Inc.

Centuries of thermal sea-level rise due to anthropogenic emissions of short-lived greenhouse gases

PubMed Central

Zickfeld, Kirsten

2017-01-01

Mitigation of anthropogenic greenhouse gases with short lifetimes (order of a year to decades) can contribute to limiting warming, but less attention has been paid to their impacts on longer-term sea-level rise. We show that short-lived greenhouse gases contribute to sea-level rise through thermal expansion (TSLR) over much longer time scales than their atmospheric lifetimes. For example, at least half of the TSLR due to increases in methane is expected to remain present for more than 200 y, even if anthropogenic emissions cease altogether, despite the 10-y atmospheric lifetime of this gas. Chlorofluorocarbons and hydrochlorofluorocarbons have already been phased out under the Montreal Protocol due to concerns about ozone depletion and provide an illustration of how emission reductions avoid multiple centuries of future TSLR. We examine the “world avoided” by the Montreal Protocol by showing that if these gases had instead been eliminated in 2050, additional TSLR of up to about 14 cm would be expected in the 21st century, with continuing contributions lasting more than 500 y. Emissions of the hydrofluorocarbon substitutes in the next half-century would also contribute to centuries of future TSLR. Consideration of the time scales of reversibility of TSLR due to short-lived substances provides insights into physical processes: sea-level rise is often assumed to follow air temperature, but this assumption holds only for TSLR when temperatures are increasing. We present a more complete formulation that is accurate even when atmospheric temperatures are stable or decreasing due to reductions in short-lived gases or net radiative forcing. PMID:28069937

Centuries of thermal sea-level rise due to anthropogenic emissions of short-lived greenhouse gases.

PubMed

Zickfeld, Kirsten; Solomon, Susan; Gilford, Daniel M

2017-01-24

Mitigation of anthropogenic greenhouse gases with short lifetimes (order of a year to decades) can contribute to limiting warming, but less attention has been paid to their impacts on longer-term sea-level rise. We show that short-lived greenhouse gases contribute to sea-level rise through thermal expansion (TSLR) over much longer time scales than their atmospheric lifetimes. For example, at least half of the TSLR due to increases in methane is expected to remain present for more than 200 y, even if anthropogenic emissions cease altogether, despite the 10-y atmospheric lifetime of this gas. Chlorofluorocarbons and hydrochlorofluorocarbons have already been phased out under the Montreal Protocol due to concerns about ozone depletion and provide an illustration of how emission reductions avoid multiple centuries of future TSLR. We examine the "world avoided" by the Montreal Protocol by showing that if these gases had instead been eliminated in 2050, additional TSLR of up to about 14 cm would be expected in the 21st century, with continuing contributions lasting more than 500 y. Emissions of the hydrofluorocarbon substitutes in the next half-century would also contribute to centuries of future TSLR. Consideration of the time scales of reversibility of TSLR due to short-lived substances provides insights into physical processes: sea-level rise is often assumed to follow air temperature, but this assumption holds only for TSLR when temperatures are increasing. We present a more complete formulation that is accurate even when atmospheric temperatures are stable or decreasing due to reductions in short-lived gases or net radiative forcing.

Rhode Island Salt Marshes: Elevation Capital and Resilience to Sea Level Rise

EPA Science Inventory

Tidal salt marsh is especially sensitive to deterioration due to the effects of accelerated sea level rise when combined with other anthropogenically linked stressors, including crab herbivory, changes in tidal hydrology, nutrient loading, dam construction, changes in temperature...

Finite difference modelling of the temperature rise in non-linear medical ultrasound fields.

PubMed

Divall, S A; Humphrey, V F

2000-03-01

Non-linear propagation of ultrasound can lead to increased heat generation in medical diagnostic imaging due to the preferential absorption of harmonics of the original frequency. A numerical model has been developed and tested that is capable of predicting the temperature rise due to a high amplitude ultrasound field. The acoustic field is modelled using a numerical solution to the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation, known as the Bergen Code, which is implemented in cylindrical symmetric form. A finite difference representation of the thermal equations is used to calculate the resulting temperature rises. The model allows for the inclusion of a number of layers of tissue with different acoustic and thermal properties and accounts for the effects of non-linear propagation, direct heating by the transducer, thermal diffusion and perfusion in different tissues. The effect of temperature-dependent skin perfusion and variation in background temperature between the skin and deeper layers of the body are included. The model has been tested against analytic solutions for simple configurations and then used to estimate temperature rises in realistic obstetric situations. A pulsed 3 MHz transducer operating with an average acoustic power of 200 mW leads to a maximum steady state temperature rise inside the foetus of 1.25 degrees C compared with a 0.6 degree C rise for the same transmitted power under linear propagation conditions. The largest temperature rise occurs at the skin surface, with the temperature rise at the foetus limited to less than 2 degrees C for the range of conditions considered.

Effects of climate change on water quality in the Yaquina ...

EPA Pesticide Factsheets

As part of a larger study to examine the effect of climate change (CC) on estuarine resources, we simulated the effect of rising sea level, alterations in river discharge, and increasing atmospheric temperatures on water quality in the Yaquina Estuary. Due to uncertainty in the effects of climate change, initial model simulations were performed for different steady river discharge rates that span the historical range in inflow, and for a range of increases in sea level and atmospheric temperature. Model simulations suggest that in the central portion of the estuary (19 km from mouth), a 60-cm increase in sea level will result in a 2-3 psu change in salinity across a broad range of river discharges. For the oligohaline portion of the estuary, salinity increases associated with a rise in sea level of 60 cm are only apparent at low river discharge rates (< 50 m3 s-1). Simulations suggest that the water temperatures near the mouth of the estuary will decrease due to rising sea level, while water temperatures in upriver portions of the estuary will increase due to rising atmospheric temperatures. We present results which demonstrate how the interaction of changes in river discharge, rising sea level, and atmospheric temperature associated with climate change produce non-linear patterns in the response of estuarine salinity and temperature, which vary with location inside the estuary and season. We also will discuss the importance of presenting results in a mann

Taxation of smokeless tobacco in India.

PubMed

Rout, S K; Arora, M

2014-12-01

The role of fiscal policy, especially taxation, though has been proved to be an effective instrument of tobacco control, its application is limited in India due to several reasons. This paper examines the tax structure, price and affordability of SLT products in order to provide evidence on how to strengthen the role of fiscal policy in tobacco control. Secondary data on tax structure and revenue from tobacco products were collected from the Ministry of Finance, Government of India. In order to measure the rise of prices corresponding to the increase in tax rate, the retail price index (RPI) and Whole Price Index (WPI) of SLT products were compared with the price index for all commodities for the period 2006-2012. The affordability of tobacco products is calculated by dividing prices of tobacco products by per capita income. During the last 6 years, the tax rate on SLT has gone up leading to a rise in the prices of SLT products more than the general price rise. However, the price rise is less than the per capita income growth indicating increasing affordability. The study observed a decline in the consumption of zarda and kahini due to the price increase during 2008-2013. However, the decline in the consumption of zarda is less compared with khaini due to a very low rise in its price. The prices should be raised more than the growth in income to influence consumption. Tax administration is a major challenge for SLT products and strengthening it could enhance revenue collection from SLT products.

Salt diapirs in the Dead Sea basin and their relationship to Quaternary extensional tectonics

USGS Publications Warehouse

Al-Zoubi, A.; ten Brink, Uri S.

2001-01-01

Regional extension of a brittle overburden and underlying salt causes differential loading that is thought to initiate the rise of reactive diapirs below and through regions of thin overburden. We present a modern example of a large salt diapir in the Dead Sea pull-apart basin, the Lisan diapir, which we believe was formed during the Quaternary due to basin transtension and subsidence. Using newly released seismic data that are correlated to several deep wells, we determine the size of the diapir to be 13 x 10 km. its maximum depth 7.2 km. and its roof 125 m below the surface. From seismic stratigraphy, we infer that the diapir started rising during the early to middle Pleistocene as this section of the basin underwater rapid subsidence and significant extension of the overburden. During the middle to late Pleistocene, the diapir pierced through the extensionally thinned overburden, as indicated by rim synclines, which attest to rapid salt withdrawal from the surrounding regions. Slight positive topography above the diapir and shallow folded horizons indicate that it is still rising intermittently. The smaller Sedom diapir, exposed along the western bounding fault of the basin is presently rising and forms a 200 m-high ridge. Its initiation is explained by localized E-W extension due monoclinal draping over the edge of a rapidly subsiding basin during the early to middle Pleistocene, and its continued rise by lateral squeezing due to continued rotation of the Amazyahu diagonal fault. 

Regional Sea Level Changes Projected by the NASA/GISS Atmosphere-Ocean Model

NASA Technical Reports Server (NTRS)

Russell, Gary L.; Gornitz, Vivien; Miller, James R.

1999-01-01

Sea level has been rising for the past century, and inhabitants of the Earth's coastal regions will want to understand and predict future sea level changes. In this study we present results from new simulations of the Goddard Institute for Space Studies (GISS) global atmosphere-ocean model from 1950 to 2099. Model results are compared with observed sea level changes during the past 40 years at 17 coastal stations around the world. Using observed levels of greenhouse gases between 1950 and 1990 and a compounded 0.5% annual increase in Co2 after 1990, model projections show that global sea level measured from 1950 will rise by 61 mm in the year 2000, by 212 mm in 2050, and by 408 mm in 2089. By 2089, two thirds of the global sea level rise will be due to thermal expansion and one third will be due to ocean mass changes. The spatial distribution of sea level rise is different than that projected by rigid lid ocean models.

Helium recovery and purification at CHMFL

NASA Astrophysics Data System (ADS)

Li, J.; Meng, Q.; Ouyang, Z.; Shi, L.; Ai, X.; Chen, X.

2017-02-01

Currently, rising demand and declining reserves of helium have led to dramatic increases in the helium price. The High Magnetic Field Laboratory of Chinese Academy of Sciences (CHMFL) has made efforts since its foundation to increase the percentage of helium recovered. The piping network connects all the helium experimental facilities to the recovery system, and even exhaust ports of pressure relief valves and vacuum pumps are also connected. In each year, about 30,000 cubic meters helium gas is recovered. The recovery gas is purified, liquefied and supplied to the users again. This paper will provide details about the helium recovery and purification system at CHMFL, including system flowchart, components, problems and solutions.

Mid-Cretaceous charred fossil flowers reveal direct observation of arthropod feeding strategies

PubMed Central

Hartkopf-Fröder, Christoph; Rust, Jes; Wappler, Torsten; Friis, Else Marie; Viehofen, Agnes

2012-01-01

Although plant–arthropod relationships underpin the dramatic rise in diversity and ecological dominance of flowering plants and their associated arthropods, direct observations of such interactions in the fossil record are rare, as these ephemeral moments are difficult to preserve. Three-dimensionally preserved charred remains of Chloranthistemon flowers from the Late Albian to Early Cenomanian of Germany preserve scales of mosquitoes and an oribatid mite with mouthparts inserted into the pollen sac. Mosquitoes, which today are frequent nectar feeders, and the mite were feeding on pollen at the time wildfire consumed the flowers. These findings document directly arthropod feeding strategies and their role in decomposition. PMID:21900310

Cold Reversal on Kodiak Island, Alaska, Correlated with the European Younger Dryas by Using Variations of Atmospheric C-14 Content

NASA Technical Reports Server (NTRS)

Hajdas, Irka; Bonani, Georges; Boden, Per; Peteet, Dorothy M.; Mann, Daniel H.

1999-01-01

High-resolution AMS (accelerator-mass-spectrometer) radiocarbon dating was performed on late-glacial macrofossils in lake sediments from Kodiak Island, Alaska, and on shells in marine sediments from southwest Sweden. In both records, a dramatic drop in radiocarbon ages equivalent to a rise in the atmospheric C-14 by approximately 70%. coincides with the beginning of the cold period at 11000 yr B.P. (C-14 age). Thus our results show that a close correlation between climatic records around the globe is possible by using a global signature of changes in atmospheric C-14 content.

Global Increases in Individualism.

PubMed

Santos, Henri C; Varnum, Michael E W; Grossmann, Igor

2017-09-01

Individualism appears to have increased over the past several decades, yet most research documenting this shift has been limited to the study of a handful of highly developed countries. Is the world becoming more individualist as a whole? If so, why? To answer these questions, we examined 51 years of data on individualist practices and values across 78 countries. Our findings suggest that individualism is indeed rising in most of the societies we tested. Despite dramatic shifts toward greater individualism around the world, however, cultural differences remain sizable. Moreover, cultural differences are primarily linked to changes in socioeconomic development, and to a lesser extent to shifts in pathogen prevalence and disaster frequency.

Developing a pain management program through continuous improvement strategies.

PubMed

Woodward, Dora

2005-01-01

Pain affects more than one third of cancer patients in the early stages of their disease, dramatically rising above 70% in the advanced stages. Numerous studies have been conducted in the pursuit of cancer pain relief, yet the prevalence of pain persists. This article focuses on a pain management program, developed by a performance improvement team, which addressed the inadequacies of current pain management. Performance improvement activities are described through the process of assessment, planning, implementation, and evaluation of the pain management program. This pain management program is uniquely derived from a unit core value that all staff is responsible and accountable for pain management.

The association of pituitary tumors and headache.

PubMed

Levy, Miles J

2011-04-01

Pituitary tumors may give rise to headache via numerous mechanisms. The traditional explanation for headache is dural stretch and cavernous sinus invasion, although this is not borne out by clinical studies. Certain functional pituitary tumors are associated with headache, notably growth hormone and prolactin-secreting tumors. The observation that somatostatin analogues can have a dramatic analgesic effect in acromegaly suggests that biochemical properties of the tumor may be important. The genetic predisposition of the patient to primary headache also determines whether headache occurs with pituitary tumors. This article attempts to outline the clinical features, management strategies, and key academic questions regarding the subject of pituitary tumors and headache.

Coastline Mapping and Cultural Review to Predict Sea Level Rise Impact on Hawaiian Archeological Sites

NASA Astrophysics Data System (ADS)

Clinton, J.

2017-12-01

Much of Hawaii's history is recorded in archeological sites. Researchers and cultural practitioners have been studying and reconstructing significant archeological sites for generations. Climate change, and more specifically, sea level rise may threaten these sites. Our research records current sea levels and then projects possible consequences to these cultural monuments due to sea level rise. In this mixed methods study, research scientists, cultural practitioners, and secondary students use plane-table mapping techniques to create maps of coastlines and historic sites. Students compare historical records to these maps, analyze current sea level rise trends, and calculate future sea levels. They also gather data through interviews with community experts and kupuna (elders). If climate change continues at projected rates, some historic sites will be in danger of negative impact due to sea level rise. Knowing projected sea levels at specific sites allows for preventative action and contributes to raised awareness of the impacts of climate change to the Hawaiian Islands. Students will share results with the community and governmental agencies in hopes of inspiring action to minimize climate change. It will take collaboration between scientists and cultural communities to inspire future action on climate change.

Sun Radio Interferometer Space Experiment (SunRISE)

NASA Astrophysics Data System (ADS)

Kasper, Justin C.; SunRISE Team

2018-06-01

The Sun Radio Interferometer Space Experiment (SunRISE) is a NASA Heliophysics Explorer Mission of Opportunity currently in Phase A. SunRISE is a constellation of spacecraft flying in a 10-km diameter formation and operating as the first imaging radio interferometer in space. The purpose of SunRISE is to reveal critical aspects of solar energetic particle (SEP) acceleration at coronal mass ejections (CMEs) and transport into space by making the first spatially resolved observations of coherent Type II and III radio bursts produced by electrons accelerated at CMEs or released from flares. SunRISE will focus on solar Decametric-Hectometric (DH, 0.1 < f < 15 MHz) radio bursts that always are detected from space before major SEP events, but cannot be seen on Earth due to ionospheric absorption. This talk will describe SunRISE objectives and implementation. Presented on behalf of the entire SunRISE team.

Subcortical Plasticity Following Perceptual Learning in a Pitch Discrimination Task

PubMed Central

Plack, Christopher J.

2010-01-01

Practice can lead to dramatic improvements in the discrimination of auditory stimuli. In this study, we investigated changes of the frequency-following response (FFR), a subcortical component of the auditory evoked potentials, after a period of pitch discrimination training. Twenty-seven adult listeners were trained for 10 h on a pitch discrimination task using one of three different complex tone stimuli. One had a static pitch contour, one had a rising pitch contour, and one had a falling pitch contour. Behavioral measures of pitch discrimination and FFRs for all the stimuli were measured before and after the training phase for these participants, as well as for an untrained control group (n = 12). Trained participants showed significant improvements in pitch discrimination compared to the control group for all three trained stimuli. These improvements were partly specific for stimuli with the same pitch modulation (dynamic vs. static) and with the same pitch trajectory (rising vs. falling) as the trained stimulus. Also, the robustness of FFR neural phase locking to the sound envelope increased significantly more in trained participants compared to the control group for the static and rising contour, but not for the falling contour. Changes in FFR strength were partly specific for stimuli with the same pitch modulation (dynamic vs. static) of the trained stimulus. Changes in FFR strength, however, were not specific for stimuli with the same pitch trajectory (rising vs. falling) as the trained stimulus. These findings indicate that even relatively low-level processes in the mature auditory system are subject to experience-related change. PMID:20878201

Subcortical plasticity following perceptual learning in a pitch discrimination task.

PubMed

Carcagno, Samuele; Plack, Christopher J

2011-02-01

Practice can lead to dramatic improvements in the discrimination of auditory stimuli. In this study, we investigated changes of the frequency-following response (FFR), a subcortical component of the auditory evoked potentials, after a period of pitch discrimination training. Twenty-seven adult listeners were trained for 10 h on a pitch discrimination task using one of three different complex tone stimuli. One had a static pitch contour, one had a rising pitch contour, and one had a falling pitch contour. Behavioral measures of pitch discrimination and FFRs for all the stimuli were measured before and after the training phase for these participants, as well as for an untrained control group (n = 12). Trained participants showed significant improvements in pitch discrimination compared to the control group for all three trained stimuli. These improvements were partly specific for stimuli with the same pitch modulation (dynamic vs. static) and with the same pitch trajectory (rising vs. falling) as the trained stimulus. Also, the robustness of FFR neural phase locking to the sound envelope increased significantly more in trained participants compared to the control group for the static and rising contour, but not for the falling contour. Changes in FFR strength were partly specific for stimuli with the same pitch modulation (dynamic vs. static) of the trained stimulus. Changes in FFR strength, however, were not specific for stimuli with the same pitch trajectory (rising vs. falling) as the trained stimulus. These findings indicate that even relatively low-level processes in the mature auditory system are subject to experience-related change.

Rise and Fall of one of World's largest deltas; the Mekong delta in Vietnam

NASA Astrophysics Data System (ADS)

Minderhoud, P. S. J.; Eslami Arab, S.; Pham, H. V.; Erkens, G.; van der Vegt, M.; Oude Essink, G.; Stouthamer, E.; Hoekstra, P.

2017-12-01

The Mekong delta is the third's largest delta in the world. It is home to almost 20 million people and an important region for the food security in South East Asia. As most deltas, the Mekong delta is the dynamic result of a balance of sediment supply, sea level rise and subsidence, hosting a system of fresh and salt water dynamics. Ongoing urbanization, industrialization and intensification of agricultural practices in the delta, during the past decades, resulted in growing domestic, agricultural and industrial demands, and have led to a dramatic increase of fresh water use. Since the year 2000, the amount of fresh groundwater extracted from the subsurface increased by 500%. This accelerated delta subsidence as the groundwater system compacts, with current sinking rates exceeding global sea level rise up to an order of magnitude. These high sinking rates have greatly altered the sediment budget of the delta and, with over 50% of the Mekong delta surface elevated less than 1 meter above sea level, greatly increase vulnerability to flooding and storm surges and ultimately, permanent inundation. Furthermore, as the increasingly larger extractions rapidly reduce the fresh groundwater reserves, groundwater salinization subsequently increases. On top of that, dry season low-flows by the Mekong river cause record salt water intrusion in the delta's estuarine system, creating major problems for rice irrigation. We present the work of three years research by the Dutch-Vietnamese `Rise and Fall' project on land subsidence and salinization in both groundwater and surface water in the Vietnamese Mekong delta.

The contribution of sea-level rise to flooding in large river catchments

NASA Astrophysics Data System (ADS)

Thiele-Eich, I.; Hopson, T. M.; Gilleland, E.; Lamarque, J.; Hu, A.; Simmer, C.

2012-12-01

Climate change is expected to both impact sea level rise as well as flooding. Our study focuses on the combined effect of climate change on upper catchment precipitation as well as on sea-level rise at the river mouths and the impact this will have on river flooding both at the coast and further upstream. We concentrate on the eight catchments of the Amazonas, Congo, Orinoco, Ganges/Brahmaputra/Meghna, Mississippi, St. Lawrence, Danube and Niger rivers. To assess the impact of climate change, upper catchment precipitation as well as monthly mean thermosteric sea-level rise at the river mouth outflow are taken from the four CCSM4 1° 20th Century ensemble members as well as from six CCSM4 1° ensemble members for the RCP scenarios RCP8.5, 6.0, 4.5 and 2.6. Continuous daily time series for average catchment precipitation and discharge are available for each of the catchments. To arrive at a future discharge time series, we used these observations to develop a simple statistical hydrological model which can be applied to the modelled future upper catchment precipitation values. The analysis of this surrogate discharge time series alone already yields significant changes in flood return levels as well as flood duration. Using the geometry of the river channel, the backwater effect of sea-level rise is incorporated in our analysis of both flood frequencies and magnitudes by calculating the effective additional discharge due to the increase in water level at the river mouth outflow, as well as its tapering impact upstream. By combining these effects, our results focus on the merged impact of changes in extreme precipitation with increases in river height due to sea-level rise at the river mouths. Judging from our preliminary results, the increase in effective discharge due to sea-level rise cannot be neglected when discussing late 21st century flooding in the respective river basins. In particular, we find that especially in countries with low elevation gradient, flood characteristics are impacted by changes in sea-level rise as far inland as 150 kilometers. Therefore, a larger population than the coastal inhabitants alone are exposed to risks of further projected increases of sea-level rise. A prime example for a megacity greatly put at risk by this is Dhaka City in Bangladesh, with a population of roughly 14 million people.

Infrared thermography based studies on mobile phone induced heating

NASA Astrophysics Data System (ADS)

Lahiri, B. B.; Bagavathiappan, S.; Soumya, C.; Jayakumar, T.; Philip, John

2015-07-01

Here, we report the skin temperature rise due to the absorption of radio frequency (RF) energy from three handheld mobile phones using infrared thermography technique. Experiments are performed under two different conditions, viz. when the mobile phones are placed in soft touch with the skin surface and away from the skin surface. Additionally, the temperature rise of mobile phones during charging, operation and simultaneous charging and talking are monitored under different exposure conditions. It is observed that the temperature of the cheek and ear regions monotonically increased with time during the usage of mobile phones and the magnitude of the temperature rise is higher for the mobile phone with higher specific absorption rate. The increase in skin temperature is higher when the mobile phones are in contact with the skin surface due to the combined effect of absorption of RF electromagnetic power and conductive heat transfer. The increase in the skin temperature in non-contact mode is found to be within the safety limit of 1 °C. The measured temperature rise is in good agreement with theoretical predictions. The empirical equation obtained from the temperature rise on the cheek region of the subjects correlates well with the specific absorption rate of the mobile phones. Our study suggests that the use of mobile phones in non-contact mode can significantly lower the skin temperature rise during its use and hence, is safer compared to the contact mode.

The Burden of Orphans and Vulnerable Children Due to HIV/AIDS in Cameroon

PubMed Central

Nsagha, Dickson S; Bissek, Anne-Cécile ZK; Nsagha, Sarah M; Assob, Jules-Clement N; Kamga, Henri-Lucien F; Njamnshi, Dora M; Njunda, Anna L; Obama, Marie-Thérèse O; Njamnshi, Alfred K

2012-01-01

HIV/AIDS is a major public health problem in Cameroon and Africa, and the challenges of orphans and vulnerable children are a threat to child survival, growth and development. The HIV prevalence in Cameroon was estimated at 5.1% in 2010. The objective of this study was to assess the burden of orphans and vulnerable children due to HIV/AIDS in Cameroon. A structured search to identify publications on orphans and other children made vulnerable by AIDS was carried out. A traditional literature search on google, PubMed and Medline using the keywords: orphans, vulnerable children, HIV/AIDS and Cameroon was conducted to identify potential AIDS orphans publications, we included papers on HIV prevalence in Cameroon, institutional versus integrated care of orphans, burden of children orphaned by AIDS and projections, impact of AIDS orphans on Cameroon, AIDS orphans assisted through the integrated care approach, and comparism of the policies of orphans care in the central African sub-region. We also used our participatory approach working experience with traditional rulers, administrative authorities and health stakeholders in Yaounde I and Yaounde VI Councils, Nanga Eboko Health District, Isangelle and Ekondo Titi Health Areas, Bafaka-Balue, PLAN Cameroon, the Pan African Institute for Development-West Africa, Save the orphans Foundation, Ministry of Social Affairs, and the Ministry of Public Health. Results show that only 9% of all OVC in Cameroon are given any form of support. AIDS death continue to rise in Cameroon. In 1995, 7,900 people died from AIDS in the country; and the annual number rose to 25,000 in 2000. Out of 1,200,000 orphans and vulnerable children in Cameroon in 2010, 300,000(25%) were AIDS orphans. Orphans and the number of children orphaned by AIDS has increased dramatically from 13,000 in 1995 to 304,000 in 2010. By 2020, this number is projected to rise to 350,000. These deaths profoundly affect families, which often are split up and left without any means of support. Similarly, the death of many people in their prime working years hamper the economy. Businesses are adversely affected due to the need to recruit and train new staff. Health and social service systems suffer from the loss of health workers, teachers, and other skilled workers. OVC due to HIV/AIDS are a major public health problem in Cameroon as the HIV prevalence continues its relentless increase with 141 new infections per day. In partnership with the Ministry of Social Affairs and other development organizations, the Ministry of Public Health has been striving hard to provide for the educational and medical needs of the OVC, vocational training for the out-of- school OVC and income generating activities for foster families and families headed by children. A continous multi-sectorial approach headed by the government to solve the problem of OVC due to AIDS is very important. In line with the foregoing, recommendations are proposed for the way forward. PMID:23248738

NRMRL'S NUTRIENT-RELATED RISK MANAGEMENT RESEARCH

EPA Science Inventory

Anthropogenic loadings of nutrients into our Nation's atmosphere, aquatic, and terrestrial ecosystems have increased dramatically within the past few decades. Environmental impairments associated with this over fertilization include aquatic habitat loss due to low dissolved oxyge...

Sea-level rise and coastal groundwater inundation and shoaling at select sites in California, USA

USGS Publications Warehouse

Hoover, Daniel J.; Odigie, Kingsley; Swarzenski, Peter W.; Barnard, Patrick

2017-01-01

Study regionThe study region spans coastal California, USA, and focuses on three primary sites: Arcata, Stinson Beach, and Malibu Lagoon.Study focus1 m and 2 m sea-level rise (SLR) projections were used to assess vulnerability to SLR-driven groundwater emergence and shoaling at select low-lying, coastal sites in California. Separate and combined inundation scenarios for SLR and groundwater emergence were developed using digital elevation models of study site topography and groundwater surfaces constructed from well data or published groundwater level contours.New hydrological insights for the regionSLR impacts are a serious concern in coastal California which has a long (∼1800 km) and populous coastline. Information on the possible importance of SLR-driven groundwater inundation in California is limited. In this study, the potential for SLR-driven groundwater inundation at three sites (Arcata, Stinson Beach, and Malibu Lagoon) was investigated under 1 m and 2 m SLR scenarios. These sites provide insight into the vulnerability of Northern California coastal plains, coastal developments built on beach sand or sand spits, and developed areas around coastal lagoons associated with seasonal streams and berms. Northern California coastal plains with abundant shallow groundwater likely will see significant and widespread groundwater emergence, while impacts along the much drier central and southern California coast may be less severe due to the absence of shallow groundwater in many areas. Vulnerability analysis is hampered by the lack of data on shallow coastal aquifers, which commonly are not studied because they are not suitable for domestic or agricultural use. Shallow saline aquifers may be present in many areas along coastal California, which would dramatically increase vulnerability to SLR-driven groundwater emergence and shoaling. Improved understanding of the extent and response of California coastal aquifers to SLR will help in preparing for mitigation and adaptation.

[Ecological risk assessment of land use based on exploratory spatial data analysis (ESDA): a case study of Haitan Island, Fujian Province].

PubMed

Wu, Jian; Chen, Peng; Wen, Chao-Xiang; Fu, Shi-Feng; Chen, Qing-Hui

2014-07-01

As a novel environment management tool, ecological risk assessment has provided a new perspective for the quantitative evaluation of ecological effects of land-use change. In this study, Haitan Island in Fujian Province was taken as a case. Based on the Landsat TM obtained in 1990, SPOT5 RS images obtained in 2010, general layout planning map of Pingtan Comprehensive Experimental Zone in 2030, as well as the field investigation data, we established an ecological risk index to measure ecological endpoints. By using spatial autocorrelation and semivariance analysis of Exploratory Spatial Data Analysis (ESDA), the ecological risk of Haitan Island under different land-use situations was assessed, including the past (1990), present (2010) and future (2030), and the potential risk and its changing trend were analyzed. The results revealed that the ecological risk index showed obvious scale effect, with strong positive correlation within 3000 meters. High-high (HH) and low-low (LL) aggregations were predominant types in spatial distribution of ecological risk index. The ecological risk index showed significant isotropic characteristics, and its spatial distribution was consistent with Anselin Local Moran I (LISA) distribution during the same period. Dramatic spatial distribution change of each ecological risk area was found among 1990, 2010 and 2030, and the fluctuation trend and amplitude of different ecological risk areas were diverse. The low ecological risk area showed a rise-to-fall trend while the medium and high ecological risk areas showed a fall-to-rise trend. In the planning period, due to intensive anthropogenic disturbance, the high ecological risk area spread throughout the whole region. To reduce the ecological risk in land-use and maintain the regional ecological security, the following ecological risk control strategies could be adopted, i.e., optimizing the spatial pattern of land resources, protecting the key ecoregions and controlling the scale of construction land use.

The Challenge of High-resolution Mapping of Very Shallow Coastal Areas: Case Study of the Lagoon of Venice, Italy

NASA Astrophysics Data System (ADS)

Madricardo, F.; Foglini, F.; Kruss, A.; Bajo, M.; Campiani, E.; Ferrarin, C.; Fogarin, S.; Grande, V.; Janowski, L.; Keppel, E.; Leidi, E.; Lorenzetti, G.; Maicu, F.; Maselli, V.; Montereale Gavazzi, G.; Pellegrini, C.; Petrizzo, A.; Prampolini, M.; Remia, A.; Rizzetto, F.; Rovere, M.; Sarretta, A.; Sigovini, M.; Toso, C.; Zaggia, L.; Trincardi, F.

2017-12-01

Very shallow coastal environments are often highly urbanized with half of the world's population and 13 of the largest mega-cities located close to the coast. These environments undergo rapid morphological changes due to natural and anthropogenic pressure that will likely be enhanced in the near future by mean sea-level rise. Therefore, there is a strong need for high resolution seafloor mapping to monitor and protect shallow coastal areas. To date, only about 5% of their seafloor has been mapped: their shallowness has prevented so far the use of underwater acoustics to reveal their morphological features; their turbidity often hindered the efficient use of LIDAR technology, particularly in lagoons and estuaries. The recent technological development of multibeam echosounder systems, however, enables these instruments to achieve very high performances also in such shallow environments. In this work, we present the results of an extensive multibeam survey carried out in the Lagoon of Venice (Italy) in 2013. The Lagoon of Venice is the biggest lagoon in the Mediterranean Sea (surface area of about 550 km2, average depth of about 1 m) and it is a UNESCO World Cultural and Natural Heritage site together with the historical city of Venice which is currently endangered by relative sea-level rise. Major engineering works are ongoing at the lagoon inlets (MOSE project) to protect Venice from flood events. In the last century, the morphology and ecology of the lagoon changed dramatically: the extent of the salt marshes was reduced by 60% and some parts of the lagoon deepened by more than 1 m with a net sediment flux exiting from the inlets. To understand and monitor the future evolution of the Lagoon of Venice in view of the inlet modifications and mean sea-level rise, CNR-ISMAR within the project RITMARE (a National Research Programme funded by the Italian Ministry of University and Research) carried out an extensive survey, involving a team of more than 25 scientists, to collect high resolution (0.5 m) bathymetry of key study areas such as the tidal inlets and channels. Bathymetric and backscatter intensity data are now employed for geomorphologic studies, habitat mapping and modelling representing a paradigm of a broad multidisciplinary approach to monitor shallow coastal systems.

A low energy demand scenario for meeting the 1.5 °C target and sustainable development goals without negative emission technologies

NASA Astrophysics Data System (ADS)

Grubler, Arnulf; Wilson, Charlie; Bento, Nuno; Boza-Kiss, Benigna; Krey, Volker; McCollum, David L.; Rao, Narasimha D.; Riahi, Keywan; Rogelj, Joeri; De Stercke, Simon; Cullen, Jonathan; Frank, Stefan; Fricko, Oliver; Guo, Fei; Gidden, Matt; Havlík, Petr; Huppmann, Daniel; Kiesewetter, Gregor; Rafaj, Peter; Schoepp, Wolfgang; Valin, Hugo

2018-06-01

Scenarios that limit global warming to 1.5 °C describe major transformations in energy supply and ever-rising energy demand. Here, we provide a contrasting perspective by developing a narrative of future change based on observable trends that results in low energy demand. We describe and quantify changes in activity levels and energy intensity in the global North and global South for all major energy services. We project that global final energy demand by 2050 reduces to 245 EJ, around 40% lower than today, despite rises in population, income and activity. Using an integrated assessment modelling framework, we show how changes in the quantity and type of energy services drive structural change in intermediate and upstream supply sectors (energy and land use). Down-sizing the global energy system dramatically improves the feasibility of a low-carbon supply-side transformation. Our scenario meets the 1.5 °C climate target as well as many sustainable development goals, without relying on negative emission technologies.

The crime drop in comparative perspective: the impact of the economy and imprisonment on American and European burglary rates.

PubMed

Rosenfeld, Richard; Messner, Steven F

2009-09-01

Influential statements on recent American crime reductions maintain that the crime drop was confined to the USA. Yet other research has revealed comparable crime decreases in Europe. We suggest that the USA and European crime declines occurred in tandem because they were both brought about by upturns in the economy. In light of US research showing crime reductions resulting from growth in imprisonment, we also examine the possibility that rising imprisonment rates reduced European crime rates. We test these hypotheses in a pooled cross-sectional time-series analysis of burglary rates in the USA and nine European nations between 1993 and 2006. The results indicate that burglary declines in the US and Europe were associated with rising consumer confidence. By contrast, imprisonment appears to be significantly related to burglary rates only after unusual policy interventions, such as Italy's 2006 clemency measure that dramatically reduced the size of its prison population. We interpret these findings as reflecting the structural similarity and economic integration of the world's developed nations and the uneven convergence in US and European punishment policies.

Upper Limit for Regional Sea Level Projections

NASA Astrophysics Data System (ADS)

Jevrejeva, Svetlana; Jackson, Luke; Riva, Riccardo; Grinsted, Aslak; Moore, John

2016-04-01

With more than 150 million people living within 1 m of high tide future sea level rise is one of the most damaging aspects of warming climate. The latest Intergovernmental Panel on Climate Change report (AR5 IPCC) noted that a 0.5 m rise in mean sea level will result in a dramatic increase the frequency of high water extremes - by an order of magnitude, or more in some regions. Thus the flood threat to the rapidly growing urban populations and associated infrastructure in coastal areas are major concerns for society. Hence, impact assessment, risk management, adaptation strategy and long-term decision making in coastal areas depend on projections of mean sea level and crucially its low probability, high impact, upper range. With probabilistic approach we produce regional sea level projections taking into account large uncertainties associated with Greenland and Antarctica ice sheets contribution. We calculate the upper limit (as 95%) for regional sea level projections by 2100 with RCP8.5 scenario, suggesting that for the most coastlines upper limit will exceed the global upper limit of 1.8 m.

Exercise and the Development of the Artificial Pancreas

PubMed Central

Riddell, Michael C.; Zaharieva, Dessi P.; Yavelberg, Loren; Cinar, Ali; Jamnik, Veronica K.

2015-01-01

Regular physical activity (PA) promotes numerous health benefits for people living with type 1 diabetes (T1D). However, PA also complicates blood glucose control. Factors affecting blood glucose fluctuations during PA include activity type, intensity and duration as well as the amount of insulin and food in the body at the time of the activity. To maintain equilibrium with blood glucose concentrations during PA, the rate of glucose appearance (Ra) to disappearance (Rd) in the bloodstream must be balanced. In nondiabetics, there is a rise in glucagon and a reduction in insulin release at the onset of mild to moderate aerobic PA. During intense aerobic -anaerobic work, insulin release first decreases and then rises rapidly in early recovery to offset a more dramatic increase in counterregulatory hormones and metabolites. An “exercise smart” artificial pancreas (AP) must be capable of sensing glucose and perhaps other physiological responses to various types and intensities of PA. The emergence of this new technology may benefit active persons with T1D who are prone to hypo and hyperglycemia. PMID:26428933

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rasmussen, K.A.; Neumann, A.C.; Haddad, R.I.

The stable-isotope composition ({delta}{sup 13}C) of total organic carbon (TOC) was measured as a function of depth throughout a 217-cm-thick sequence of Holocene carbonate sediment within the Bight of Abaco lagoon, Little Bahama Bank. Biofacies and lithofacies analyses indicate progressive banktop submergence and paleoenvironmental response during Holocene sea-level rise. Stable-isotope values shift markedly from {minus}27.7{per thousand} within the 7900 B.P. paleosol at the base of the core to {minus}11.1{per thousand} at the present-day sediment-water interface. An abrupt excursion toward heavy-isotope values records the first establishment of Thalassia seagrass upon open-marine flooding. A multitracer approach, combining biofacies, lithofacies, and stable-isotope analysismore » of TOC confirms that the dramatic +17{per thousand} shift observed in {delta}{sup 13}C was a direct result of sea-level rise and associated environmental changes over the banktop; there is little evidence of spurious diagenetic overprint. Stable-isotope analyses of organic carbon may enhance the reconstruction of carbonate sequences by revealing a distinctive geochemical signature of banktop flooding, including the onset of growth of otherwise unpreservable Thalassia seagrass.« less

Rising U.S. income inequality, gender and individual self-rated health, 1972-2004.

PubMed

Zheng, Hui

2009-11-01

The effect of income inequality on health has been a contested topic among social scientists. Most previous research is based on cross-sectional comparisons rather than temporal comparisons. Using data from the General Social Survey and the U.S. Census Bureau, this study examines how rising income inequality affects individual self-rated health in the U.S. from 1972 to 2004. Data are analyzed using hierarchical generalized linear models. The findings suggest a significant association between income inequality and individual self-rated health. The dramatic increase in income inequality from 1972 to 2004 increases the odds of worse self-rated health by 9.4 percent. These findings hold for three measures of income inequality: the Gini coefficient, the Atkinson Index, and the Theil entropy index. Results also suggest that overall income inequality and gender-specific income inequality harm men's, but not women's, self-rated health. These findings also hold for the three measures of income inequality. These findings suggest that inattention to gender composition may explain apparent discrepancies across previous studies.

Parental environment mediates impacts of increased carbon dioxide on a coral reef fish

NASA Astrophysics Data System (ADS)

Miller, Gabrielle M.; Watson, Sue-Ann; Donelson, Jennifer M.; McCormick, Mark I.; Munday, Philip L.

2012-12-01

Carbon dioxide concentrations in the surface ocean are increasing owing to rising CO2 concentrations in the atmosphere. Higher CO2 levels are predicted to affect essential physiological processes of many aquatic organisms, leading to widespread impacts on marine diversity and ecosystem function, especially when combined with the effects of global warming. Yet the ability for marine species to adjust to increasing CO2 levels over many generations is an unresolved issue. Here we show that ocean conditions projected for the end of the century (approximately 1,000μatm CO2 and a temperature rise of 1.5-3.0°C) cause an increase in metabolic rate and decreases in length, weight, condition and survival of juvenile fish. However, these effects are absent or reversed when parents also experience high CO2 concentrations. Our results show that non-genetic parental effects can dramatically alter the response of marine organisms to increasing CO2 and demonstrate that some species have more capacity to acclimate to ocean acidification than previously thought.

The Contemporary Setting for Water Management in the West: An Overview

NASA Astrophysics Data System (ADS)

Cummings, Ronald G.

1985-11-01

The socioeconomic, legal, and institutional settings for water resources management and use in the United States have undergone dramatic changes over recent years. The resulting confusion and uncertainties in terms of the structure of water rights, the prerogatives of sovereign states, and the limitations of state-federal interfaces provide the raison d'être for the collection of papers in this special section of Water Resources Research. This special issue is intended to serve several purposes: to inform, to provoke, and to invite. Thus many readers may find new and informative Tarlock's [this issue] overview of the evolution of groundwater law from English Common Law to laws based on notions of "reasonable use" and "sharing"; of particular importance is the readers appreciation of the changes and uncertainties in water law associated with the 1982 decision in Sporhase and in the later El Paso case. These cases, marking an end of the "immunity theory" wherein states were immune, in cases involving resources use, from challenges under the Commerce Clause, give rise to Tarlock's concern with the question, Might current conditions give rise to federal control of groundwater?

Outer Rise Faulting And Mantle Serpentinization

NASA Astrophysics Data System (ADS)

Ranero, C. R.; Phipps Morgan, J.; McIntosh, K.; Reichert, C.

Dehydration of serpentinized mantle of the downgoing slab has been proposed to cause both intermediate depth earthquakes (50-300 km) and arc volcanism at sub- duction zones. It has been suggested that most of this serpentinization occurs beneath the outer rise; where normal faulting earthquakes due to bending cut > 20 km deep into the lithosphere, allowing seawater to reach and react with underlying mantle. However, little is known about flexural faulting at convergent margins; about how many normal faults cut across the crust and how deeply they penetrate into the man- tle; about the true potential of faults as conduits for fluid flow and how much water can be added through this process. We present evidence that pervasive flexural faulting may cut deep into the mantle and that the amount of faulting vary dramatically along strike at subduction zones. Flexural faulting increases towards the trench axis indicat- ing that active extension occurs in a broad area. Multibeam bathymetry of the Pacific margin of Costa Rica and Nicaragua shows a remarkable variation in the amount of flexural faulting along the incoming ocean plate. Several parameters seem to control lateral variability. Off south Costa Rica thick crust of the Cocos Ridge flexes little, and little to no faulting develops near the trench. Off central Costa Rica, normal thick- ness crust with magnetic anomalies striking oblique to the trench displays small offset faults (~200 m) striking similar to the original seafloor fabric. Off northern Costa Rica, magnetic anomalies strike perpendicular to the trench axis, and a few ~100m-offset faults develop parallel to the trench. Further north, across the Nicaraguan margin, magnetic anomalies strike parallel to the trench and the most widespread faulting de- velops entering the trench. Multichannel seismic reflection images in this area show a pervasive set of trenchward dipping reflections that cross the ~6 km thick crust and extend into the mantle to depths of at least 20 km. Some reflections project updip to offsets in top basement and seafloor, indicating that they are fault plane reflections. Such a deeply penetrating tectonic fabric could have not developed during crustal cre- ation at the paleo-spreading center where the brittle layer is few km thick. Thus, they must be created during flexure of the plate entering the trench. This data imply that deep and widespread serpentinization of the incoming lithosphere can occur when the lithosphere is strongly faulted; that the extent of lithospheric faulting is closely re- lated to the crustal structure of the incoming plate; and that the amount of lithosphere faulting can change dramatically within a hundred km distance along a trench axis.

Possible connection between large volcanic eruptions and level rise episodes in the Dead Sea Basin

NASA Astrophysics Data System (ADS)

Bookman, Revital; Filin, Sagi; Avni, Yoav; Rosenfeld, Daniel; Marco, Shmuel

2014-05-01

The June 1991 Pinatubo volcanic eruption perturbed the atmosphere, triggering short-term worldwide changes in surface and lower troposphere temperatures, precipitation, and runoff. The following winter was anomalously wet in the Levant, with a ~2-meter increase in the Dead Sea level that created a distinct morphological terrace along the lake's shore. Given the global radiative and chemical effects of volcanogenic aerosols on climatic systems, we tested the hypothesis that the 1991-92 winter shore terrace is a modern analogue to the linkage between past volcanic eruptions and a sequence of shore terraces on the cliffs around the Dead Sea Basin. Analysis of historical annual precipitation series from Jerusalem showed a significant positive correlation between the Dust Veil Index (DVI) of the modern largest eruptions and corresponding annual rainfall. The DVI was found to explain nearly 50% of the variability in the annual rainfall, such that greater DVI means more rainfall. Other factors that may affect the annual rainfall in the region as the Southern Oscillation Index (SOI) and the North Atlantic oscillations (NAO) were incorporated along with the DVI in a linear multiple regression model. It was found that the NAO did not contribute anything except for increased noise, but the added SOI increased the explained variability of rainfall to more than 60%. The atmospheric effect of the volcanic aerosol cloud produced after the Mt. Pinatubo eruption shows responses in the climate system on a hemispherical to global scale. Volcanic eruptions with a VEI of 6, as in the Pinatubo, occurred about once a century during the Holocene period at a rate that persisted throughout the last glacial-interglacial cycle, though with large variations in the mean. This occurrence is similar to the frequency of shore terrace build-up during the Lake Lisan desiccation. Sixteen shore terraces, detected using airborne laser scanning data, were interpreted as indicating short-term level rises due to episodes of enhanced precipitation and runoff during the dramatic drop in Lake Lisan's (palaeo-Dead Sea) level at the end of the Last Glacial Maximum. The terraces were compared with a dated time series of volcanogenic sulfate from the GISP2 ice core, and similar numbers of sulfate concentration peaks and shore terraces were found. Furthermore, a significant correlation was found between SO4 concentration peaks and the heights of the terraces. This correlation may indicate a link between the explosivity of past eruptions, the magnitude of stratospheric injection, and their impact on the northern hemisphere water balance. The record of such short-term climato-hydrological effects is made possible by the dramatic desiccation of Lake Lisan. Detailed records of such events, albeit rare because of their vulnerability and short longevity, provide an important demonstration of global climatic teleconnections.

Coastal Impact Underestimated From Rapid Sea Level Rise

NASA Astrophysics Data System (ADS)

Anderson, John; Milliken, Kristy; Wallace, Davin; Rodriguez, Antonio; Simms, Alexander

2010-06-01

A primary effect of global warming is accelerated sea level rise, which will eventually drown low-lying coastal areas, including some of the world's most populated cities. Predictions from the Fourth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) suggest that sea level may rise by as much as 0.6 meter by 2100 [Solomon et al., 2007]. However, uncertainty remains about how projected melting of the Greenland and Antarctic ice sheets will contribute to sea level rise. Further, considerable variability is introduced to these calculations due to coastal subsidence, especially along the northern Gulf of Mexico (see http://tidesandcurrents.noaa.gov/sltrends/sltrends.shtml).

Review of Article, A Case for Submicrosecond Rise-Time Lightning Current Pulses for Use in Aircraft Induced-Coupling Studies, by D. W. Clifford, E. P. Krider and M. A. Uman

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabayan, H.S.; Zicker, J.D.

The amplitudes of currents due to lightning are considerably larger than NEMP induced currents both in the time and frequency domains. The more important quantity for aperture illumination is the rate of rise of the current. The analysis performed for this in this memorandum is unsatisfactory since the artificial double exponential model was used. Still, the lightning rate of rise is only twice as high as that due to NEMP even when the absolute worst (or presently known) lightning pulse is used. A much better way to do this comparison is to use an actual LEMP data and NEMP frommore » an actual weapon. Furthermore, because of lack of data, no electric field analysis was undertaken.« less

Assessment of the impact of sea-level rise due to climate change on coastal groundwater discharge.

PubMed

Masciopinto, Costantino; Liso, Isabella Serena

2016-11-01

An assessment of sea intrusion into coastal aquifers as a consequence of local sea-level rise (LSLR) due to climate change was carried out at Murgia and Salento in southern Italy. The interpolation of sea-level measurements at three tide-gauge stations was performed during the period of 2000 to 2014. The best fit of measurements shows an increasing rate of LSLR ranging from 4.4mm/y to 8.8mm/y, which will result in a maximum LSLR of approximately 2m during the 22nd century. The local rate of sea-level rise matches recent 21st and 22nd century projections of mean global sea-level rise determined by other researchers, which include increased melting rates of the Greenland and Antarctic ice sheets, the effect of ocean thermal expansion, the melting of glaciers and ice caps, and changes in the quantity of stored land water. Subsequently, Ghyben-Herzberg's equation for the freshwater/saltwater interface was rewritten in order to determine the decrease in groundwater discharge due to the maximum LSLR. Groundwater flow simulations and ArcGIS elaborations of digital elevation models of the coast provided input data for the Ghyben-Herzberg calculation under the assumption of head-controlled systems. The progression of seawater intrusion due to LSLR suggests an impressive depletion of available groundwater discharge during the 22nd century, perhaps as much as 16.1% of current groundwater pumping for potable water in Salento. Copyright © 2016 Elsevier B.V. All rights reserved.

Climate Change: Life history adaptation by a global whitefly, Bemisia tabaci, with rising temperature and carbon dioxide

USDA-ARS?s Scientific Manuscript database

Introduction: Climate change can have direct and indirect impacts on living organisms. A rise in ambient temperature and elevated carbon dioxide (CO2) concentrations due to global warming may have assorted impacts on arthropods such as altered life cycles, altered reproductive patterns, and change...

Libraries Drop Thousands of Journals as Budgets Shrink and Prices Rise.

ERIC Educational Resources Information Center

Nicklin, Julie L.

1991-01-01

University libraries are being forced to cancel subscriptions to thousands of journals, some considered essential to academic research, due to rapidly rising costs. Publishers cite increased publication costs and more articles as the source of increases. Many journals once published by nonprofit organizations have been taken over by profit-seeking…

Computing Risk to West Coast Intertidal Rocky Habitat due to Sea Level Rise using LiDAR Topobathy

EPA Science Inventory

Compared to marshes, little information is available on the potential for rocky intertidal habitats to migrate upward in response to sea level rise (SLR). To address this gap, we utilized topobathy LiDAR digital elevation models (DEMs) downloaded from NOAA’s Digital Coast G...

Impacts of climate change on sub-regional electricity demand and distribution in the southern United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, Melissa R.; Fernandez, Steven J.; Fu, Joshua S.

New tools are employed to develop an electricity demand map for the southeastern United States at neighborhood resolution to serve as a baseline from which to project increases in electricity demand due to a rise in global and local temperature and to population shifts motivated by increases in extreme weather events due to climate change. We find that electricity demand increases due to temperature rise over the next 40 years have a much smaller impact than those due to large population influx. In addition, we find evidence that some, sections of the national electrical grid are more adaptable to thesemore » population shifts and changing demand than others are; and that detailed projections of changing local electricity demand patterns are viable and important for planning at the urban level.« less

Impacts of climate change on sub-regional electricity demand and distribution in the southern United States

DOE PAGES

Allen, Melissa R.; Fernandez, Steven J.; Fu, Joshua S.; ...

2016-07-25

New tools are employed to develop an electricity demand map for the southeastern United States at neighborhood resolution to serve as a baseline from which to project increases in electricity demand due to a rise in global and local temperature and to population shifts motivated by increases in extreme weather events due to climate change. We find that electricity demand increases due to temperature rise over the next 40 years have a much smaller impact than those due to large population influx. In addition, we find evidence that some, sections of the national electrical grid are more adaptable to thesemore » population shifts and changing demand than others are; and that detailed projections of changing local electricity demand patterns are viable and important for planning at the urban level.« less

Response of marine copepods to a changing tropical environment: winners, losers and implications.

PubMed

Chew, Li Lee; Chong, Ving Ching

2016-01-01

Background. Climate change concurrent with anthropogenic disturbances can initiate serial changes that reverberate up the food chain with repercussions for fisheries. To date, there is no information available concerning the combined effects of global warming and human impacts on tropical marine food webs. While temperate copepods respond differently to warming and environmental stressors, the extent to which tropical copepods can adapt to rising temperature of already warm waters remains unknown. We hypothesize that sea warming and other anthropogenic disturbances over the long term will have the greatest impact on the copepod community in nearshore waters where their effects are accentuated, and therefore vulnerable and resilient species could be identified. Methods. Zooplankton samples were collected during two time periods (1985-86 and 2014-15) interposed by marked anthropogenic disturbances, and at the same five stations located progressively from inshore to offshore in Klang Strait, Malaysia, following the asymmetrical before-after-control-impact (BACI) design. Copepods were identified to species, and results were interpreted by univariate (ANOVA) and multivariate (PERMANOVA, PCO) analyses of the computed species abundance and diversity measures. Results. Copepod total abundance was not significantly different among stations but higher after disturbance than before disturbance. However, changes in the abundance of particular species and the community structure between time periods were dramatic. Coastal large-bodied calanoid species (e.g., Acartia spinicauda, Calanopia thompsoni, Pseudodiaptomus bowmani and Tortanus forcipatus) were the most vulnerable group to disturbance. This however favored the opportunistic species (e.g., Oithona simplex, O. attenuata, Hemicyclops sp., Pseudomacrochiron sp. and Microsetella norvegica). Small-bodied copepods (e.g., Paracalanus sp., Parvocalanus crassirostris and Euterpina acutifrons) were unaffected. Centropages tenuiremis was likely an introduced species. There was no significant loss in species richness of copepods despite the dramatic changes in community structure. Discussion. Sea warming and other human-induced effects such as eutrophication, acidification and coastal habitat degradation are likely the main factors that have altered copepod community structure. The large-bodied estuarine and coastal calanoid copepods are surmised to be vulnerable to eutrophication and hypoxia, while both resilient and opportunistic species are largely unaffected by, or adaptable to, degraded coastal environments and observed sea surface temperature (SST) rise. It is forecasted that SST rise with unmitigated anthropogenic impacts will further reduce large-bodied copepod species the favoured food for fish larvae with dire consequences for coastal fish production.

Response of marine copepods to a changing tropical environment: winners, losers and implications

PubMed Central

Chew, Li Lee

2016-01-01

Background. Climate change concurrent with anthropogenic disturbances can initiate serial changes that reverberate up the food chain with repercussions for fisheries. To date, there is no information available concerning the combined effects of global warming and human impacts on tropical marine food webs. While temperate copepods respond differently to warming and environmental stressors, the extent to which tropical copepods can adapt to rising temperature of already warm waters remains unknown. We hypothesize that sea warming and other anthropogenic disturbances over the long term will have the greatest impact on the copepod community in nearshore waters where their effects are accentuated, and therefore vulnerable and resilient species could be identified. Methods. Zooplankton samples were collected during two time periods (1985–86 and 2014–15) interposed by marked anthropogenic disturbances, and at the same five stations located progressively from inshore to offshore in Klang Strait, Malaysia, following the asymmetrical before-after-control-impact (BACI) design. Copepods were identified to species, and results were interpreted by univariate (ANOVA) and multivariate (PERMANOVA, PCO) analyses of the computed species abundance and diversity measures. Results. Copepod total abundance was not significantly different among stations but higher after disturbance than before disturbance. However, changes in the abundance of particular species and the community structure between time periods were dramatic. Coastal large-bodied calanoid species (e.g., Acartia spinicauda, Calanopia thompsoni, Pseudodiaptomus bowmani and Tortanus forcipatus) were the most vulnerable group to disturbance. This however favored the opportunistic species (e.g., Oithona simplex, O. attenuata, Hemicyclops sp., Pseudomacrochiron sp. and Microsetella norvegica). Small-bodied copepods (e.g., Paracalanus sp., Parvocalanus crassirostris and Euterpina acutifrons) were unaffected. Centropages tenuiremis was likely an introduced species. There was no significant loss in species richness of copepods despite the dramatic changes in community structure. Discussion. Sea warming and other human-induced effects such as eutrophication, acidification and coastal habitat degradation are likely the main factors that have altered copepod community structure. The large-bodied estuarine and coastal calanoid copepods are surmised to be vulnerable to eutrophication and hypoxia, while both resilient and opportunistic species are largely unaffected by, or adaptable to, degraded coastal environments and observed sea surface temperature (SST) rise. It is forecasted that SST rise with unmitigated anthropogenic impacts will further reduce large-bodied copepod species the favoured food for fish larvae with dire consequences for coastal fish production. PMID:27257540

Functionalized graphene nanomaterials: new insight into direct exfoliation of graphite with supramolecular polymers

NASA Astrophysics Data System (ADS)

Cheng, Chih-Chia; Chang, Feng-Chih; Wang, Jui-Hsu; Chen, Jem-Kun; Yen, Ying-Chieh; Lee, Duu-Jong

2015-12-01

A novel urea-cytosine end-capped polypropylene glycol (UrCy-PPG) can self-assemble into a long-range ordered lamellar microstructure on the surface of graphene, due to the strong specific interactions between UrCy-PPG and graphene. In addition, the graphene composite produced exhibits a high conductivity (~1093 S m-1) with a dramatic thermo-responsive ON/OFF resistance-switching behavior (10 consecutive cycles).A novel urea-cytosine end-capped polypropylene glycol (UrCy-PPG) can self-assemble into a long-range ordered lamellar microstructure on the surface of graphene, due to the strong specific interactions between UrCy-PPG and graphene. In addition, the graphene composite produced exhibits a high conductivity (~1093 S m-1) with a dramatic thermo-responsive ON/OFF resistance-switching behavior (10 consecutive cycles). Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr07076g

The rising greenhouse effect: experiments and observations in and around the Alps

NASA Astrophysics Data System (ADS)

Philipona, R.

2010-09-01

The rapid temperature increase of more than 1°C in central Europe over the last three decades is larger than expected from anthropogenic greenhouse warming. Surface radiation flux measurements in and around the Alps in fact confirm that not only thermal longwave radiation but also solar shortwave radiation increased since the 1980s. Surface energy budget analyses reveal the rising surface temperature to be well correlated with the radiative forcing, and also show an increase of the kinetic energy fluxes explaining the rise of atmospheric water vapor. Solar radiation mainly increased due to a strong decline of anthropogenic aerosols since mid of the 1980s. While anthropogenic aerosols were mainly accumulated in the boundary layer, this reduction let solar radiation to recover (solar brightening after several decades of solar dimming) mainly at low altitudes around the Alps. At high elevations in the Alps, solar forcing is much smaller and the respective temperature rise is also found to be smaller than in the lowlands. The fact that temperature increases less in the Alps than at low elevations is unexpected in the concept of greenhouse warming, but the radiation budget analyses clearly shows that in the plains solar forcing due to declining aerosols additionally increased surface temperature, whereas in the Alps temperature increased primarily due to greenhouse warming that is particularly manifested by a strong water vapor feedback.

Crustal structure of the Agulhas Ridge (South Atlantic Ocean): Formation above a hotspot?

NASA Astrophysics Data System (ADS)

Jokat, Wilfried; Hagen, Claudia

2017-10-01

The southern South Atlantic Ocean contains several features believed to document the traces of hotspot volcanism during the early formation of the ocean basin, namely the Agulhas Ridge and the Cape Rise seamounts located in the southeast Atlantic between 36°S and 50°S. The Agulhas Ridge parallels the Agulhas-Falkland Fracture Zone, one of the major transform zones of the world. The morphology of the ridge changes dramatically from two parallel segments in the southwest, to the broad plateau-like Agulhas Ridge in the northeast. Because the crustal fabric of the ridge is unknown relating its evolution to hotspots in the southeast Atlantic is an open question. During the RV Polarstern cruise ANT-XXIII-5 seismic reflection and refraction data were collected along a 370 km long profile with 8 Ocean Bottom Stations to investigate its crustal fabric. The profile extends in NNE direction from the Agulhas Basin, 60 km south of the Agulhas Ridge, and continues into the Cape Basin crossing the southernmost of the Cape Rise seamounts. In the Cape Basin we found a crustal thickness of 5.5-7.5 km, and a velocity distribution typical for oceanic crust. The Cape Rise seamounts, however, show a higher velocity in comparison to the surrounding oceanic crust and the Agulhas Ridge. Underplated material is evident below the southernmost of the Cape Rise seamounts. It also has a 5-8% higher density compared to the Agulhas Plateau. The seismic velocities of the Agulhas Ridge are lower, the crustal thickness is approximately 14 km, and age dating of dredge samples from its top provides clear evidence of rejuvenated volcanism at around 26 Ma. Seismic data indicate that although the Cape Rise seamounts formed above a mantle thermal anomaly it had a limited areal extent, whereas the hotspot material that formed the Agulhas Ridge likely erupted along a fracture zone.

Prevention of Over-Pressurization During Combustion in a Sealed Chamber

NASA Technical Reports Server (NTRS)

Gokoglu, Suleyman A.; Niehaus, Justin E.; Olson, Sandra L.; Dietrich, Daniel L.; Ruff, Gary A.; Johnston, Michael C.

2012-01-01

The combustion of flammable material in a sealed chamber invariably leads to an initial pressure rise in the volume. The pressure rise is due to the increase in the total number of gaseous moles (condensed fuel plus chamber oxygen combining to form gaseous carbon dioxide and water vapor) and, most importantly, the temperature rise of the gas in the chamber. Though the rise in temperature and pressure would reduce with time after flame extinguishment due to the absorption of heat by the walls and contents of the sealed spacecraft, the initial pressure rise from a fire, if large enough, could lead to a vehicle over-pressure and the release of gas through the pressure relief valve. This paper presents a simple lumped-parameter model of the pressure rise in a sealed chamber resulting from the heat release during combustion. The transient model considers the increase in gaseous moles due to combustion, and heat transfer to the chamber walls by convection and radiation and to the fuel-sample holder by conduction, as a function of the burning rate of the material. The results of the model are compared to the pressure rise in an experimental chamber during flame spread tests as well as to the pressure falloff after flame extinguishment. The experiments involve flame spread over thin solid fuel samples. Estimates of the heat release rate profiles for input to the model come from the assumed stoichiometric burning of the fuel along with the observed flame spread behavior. The sensitivity of the model to predict maximum chamber pressure is determined with respect to the uncertainties in input parameters. Model predictions are also presented for the pressure profile anticipated in the Fire Safety-1 experiment, a material flammability and fire safety experiment proposed for the European Space Agency (ESA) Automated Transfer Vehicle (ATV). Computations are done for a range of scenarios including various initial pressures and sample sizes. Based on these results, various mitigation approaches are suggested to prevent vehicle over-pressurization and help guide the definition of the space experiment.

Sea-level rise risks to coastal cities

NASA Astrophysics Data System (ADS)

Nicholls, Robert J.

2017-04-01

Understanding the consequence of sea-level rise for coastal cities has long lead times and huge political implications. Civilisation has emerged and developed during a period of several thousand years during which in geological terms sea level has been unusually stable. We have now moved out of this period and the challenge will be to develop a long-term proactive assessment approach to manage this challenge. In 2005 there were 136 coastal cities with a population exceeding one million people and a collective population of 400 million people. All these coastal cities are threatened by flooding from the sea to varying degrees and these risks are increasing due to growing exposure (people and assets), rising sea levels due to climate change, and in some cities, significant coastal subsidence due to human agency (drainage and groundwater withdrawals from susceptible soils). In these cities we wish to avoid major flood events, with associated damage and potentially deaths and ultimately decline of the cities. Flood risks grow with sea-level rise as it raises extreme sea levels. As sea levels continue to rise, protection will have to be progressively upgraded. Even with this, the magnitude of losses when flood events do occur would increase as coastal cities expand, and water depths and hence unit damage increase with sea-level rise/subsidence. This makes it critical to also prepare for larger coastal flood disasters than we experience today and raises questions on the limits to adaptation. There is not an extensive literature or significant empirical information on the limits to adaptation in coastal cities. These limits are not predictable in a formal sense - while the rise in mean sea level raises the likelihood of a catastrophic flood, extreme events are what cause damage and trigger a response, be it abandonment, a defence upgrade or something else. There are several types of potential limits that could be categorised into three broad types: • Physical/engineering limits; • Economic/financial limits; • Socio-political limits. These limits will be discussed and their implications considered and place in the context of long-term planning for these issues.

Multiple Quasi-Equilibria of the ITCZ and the Origin of Monsoon Onset. Part 2; Rotational ITCZ Attractors

NASA Technical Reports Server (NTRS)

Chao, Winston C.; Chen, Baode; Einaudi, Franco (Technical Monitor)

2000-01-01

Chao's numerical and theoretical work on multiple quasi-equilibria of the intertropical convergence zone (ITCZ) and the origin of monsoon onset is extended to solve two additional puzzles. One is the highly nonlinear dependence on latitude of the "force" acting on the ITCZ due to earth's rotation, which makes the multiple quasi-equilibria of the ITCZ and monsoon onset possible. The other is the dramatic difference in such dependence when different cumulus parameterization schemes are used in a model. Such a difference can lead to a switch between a single ITCZ at the equator and a double ITCZ, when a different cumulus parameterization scheme is used. Sometimes one of the double ITCZ can diminish and only the other remain, but still this can mean different latitudinal locations for the single ITCZ. A single idea based on two off-equator attractors for the ITCZ, due to earth's rotation and symmetric with respect to the equator, and the dependence of the strength and size of these attractors on the cumulus parameterization scheme solves both puzzles. The origin of these rotational attractors, explained in Part I, is further discussed. The "force" acting on the ITCZ due to earth's rotation is the sum of the "forces" of the two attractors. Each attractor exerts on the ITCZ a "force" of simple shape in latitude; but the sum gives a shape highly varying in latitude. Also the strength and the domain of influence of each attractor vary, when change is made in the cumulus parameterization. This gives rise to the high sensitivity of the "force" shape to cumulus parameterization. Numerical results, of experiments using Goddard's GEOS general circulation model, supporting this idea are presented. It is also found that the model results are sensitive to changes outside of the cumulus parameterization. The significance of this study to El Nino forecast and to tropical forecast in general is discussed.

Insights about the interaction between sea-level rise, sediment accumulation and subsidence: the example of the Ganges Brahmaputra Delta during the Holocene

NASA Astrophysics Data System (ADS)

Grall, C.; Steckler, M. S.; Pickering, J.; Goodbred, S. L., Jr.; Sincavage, R.; Hossain, S.; Paola, C.; Spiess, V.

2016-12-01

The hazard associated with sea-level rise (shoreline erosion, flooding and wetlands loss) may dramatically increase when human interventions interfere with the natural responses of the coastal regions to the eustatic rise. We here provide insights about such natural processes, by documenting the manner in which subsidence, sediment input and sediment distribution interact together during the well-known Holocene eustatic rise period, in the Ganges- Brahmaputra-Meghna Delta (GBMD) in Bangladesh. The dataset combines more than 400 hand-drilled stratigraphic wells, 185 radiocarbon ages, and seismic reflection imaging data (255 km of high resolution multichannel seismic dataset), collected thanks to recent research in the BanglaPIRE project. We use two independent approaches for analyzing this broad dataset. First, we estimate the total volume of Holocene sediments in the GBMD. In doing so, we define empirical laws to build up a virtual model of sediment accumulation that takes into account the contrasts in accumulation between rivers and alluvial plains as well as the regional seaward gradient of sediment accumulation. As the evolution of river occupation over the Holocene at the regional scale is now relatively well constrained, we estimate the total volume of sediment deposited in the Delta during the Holocene. Secondly, we use detailed age-models of sediment accumulation at 92 sites (based on 185 radiocarbon ages) for distinguishing the effects of eustasy and subsidence on the sediment accumulation in the different domains of the delta (namely the tidal dominated plain and the fluvial dominated plain). Using these two independent approaches, we are able to quantify the natural subsidence and the relative distribution of subsidence. We emphasize the difference between the subsidence and the sediment accumulation, by showing that sediment accumulation is more than twice the subsidence on average during the Holocene, which allows us to quantify the increase of sediment deposition associated with the eustatic rise in sea-level. We suggests that consequences of sediment starvation in low lying lands associated with human impacts may be masked, and thus underappreciated, during periods of eustatic rise in sea-level.

Antibiotic resistance among Ureaplasma spp. isolates: cause for concern?

PubMed

Beeton, M L; Spiller, O B

2017-02-01

There is growing global concern regarding the rise of antibiotic-resistant organisms. Many of these reports have focused on various Gram-positive and Gram-negative pathogens, with little attention to the genus Ureaplasma. Ureaplasma spp. are associated with numerous infectious diseases affecting pregnant women, neonates and the immunocompromised. Treatment options are extremely limited due to high levels of intrinsic resistance resulting from the unique physiology of these organisms and further restricted in cases of the developing fetus or neonate, often limiting therapeutic options to predominantly macrolides or rarely fluoroquinolones. The increasing presence of macrolide- and fluoroquinolone-resistant strains among neonatal infections may result in pan-drug resistance and potentially untreatable conditions. Here, we review the requirements for accurate measurement of antimicrobial susceptibility, provide a comprehensive review of the antimicrobial resistance (AMR) for Ureaplasma species in the literature and contextualize these results relative to some investigators' reliance on commercial kits that are not CLSI compliant when determining AMR. The dramatic variation in the resistance patterns and impact of high levels of AMR amongst neonatal populations suggests the need for continued surveillance. Commercial kits represent an excellent tool for initial antibiotic susceptibility determination and screening. However, AMR reporting must utilize internationally standardized methods, as high-titre samples, or Mycoplasma hominis-contaminated samples routinely give false AMR results. Furthermore, there is a requirement for future reports to determine the underlying AMR mechanisms and determine whether expanding AMR is due to spontaneous mutation, transmission of resistance genes on mobile elements or selection and expansion of resistant clones. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Potential impact of predicted sea level rise on carbon sink function of mangrove ecosystems with special reference to Negombo estuary, Sri Lanka

NASA Astrophysics Data System (ADS)

Perera, K. A. R. S.; De Silva, K. H. W. L.; Amarasinghe, M. D.

2018-02-01

Unique location in the land-sea interface makes mangrove ecosystems most vulnerable to the impacts of predicted sea level rise due to increasing anthropogenic CO2 emissions. Among others, carbon sink function of these tropical ecosystems that contribute to reduce rising atmospheric CO2 and temperature, could potentially be affected most. Present study was undertaken to explore the extent of impact of the predicted sea level rise for the region on total organic carbon (TOC) pools of the mangrove ecosystems in Negombo estuary located on the west coast of Sri Lanka. Extents of the coastal inundations under minimum (0.09 m) and maximum (0.88 m) sea level rise scenarios of IPCC for 2100 and an intermediate level of 0.48 m were determined with GIS tools. Estimated total capacity of organic carbon retention by these mangrove areas was 499.45 Mg C ha- 1 of which 84% (418.98 Mg C ha- 1) sequestered in the mangrove soil and 16% (80.56 Mg C ha- 1) in the vegetation. Total extent of land area potentially affected by inundation under lowest sea level rise scenario was 218.9 ha, while it was 476.2 ha under intermediate rise and 696.0 ha with the predicted maximum sea level rise. Estimated rate of loss of carbon sink function due to inundation by the sea level rise of 0.09 m is 6.30 Mg C ha- 1 y- 1 while the intermediate sea level rise indicated a loss of 9.92 Mg C ha- 1 y- 1 and under maximum sea level rise scenario, this loss further increases up to 11.32 Mg C ha- 1 y- 1. Adaptation of mangrove plants to withstand inundation and landward migration along with escalated photosynthetic rates, augmented by changing rainfall patterns and availability of nutrients may contribute to reduce the rate of loss of carbon sink function of these mangrove ecosystems. Predictions over change in carbon sequestration function of mangroves in Negombo estuary reveals that it is not only affected by oceanographic and hydrological alterations associated with sea level rise but also by anthropogenic processes, therefore the impacts are site specific in terms of distribution and magnitude.

The case for probabilistic forecasting in hydrology

NASA Astrophysics Data System (ADS)

Krzysztofowicz, Roman

2001-08-01

That forecasts should be stated in probabilistic, rather than deterministic, terms has been argued from common sense and decision-theoretic perspectives for almost a century. Yet most operational hydrological forecasting systems produce deterministic forecasts and most research in operational hydrology has been devoted to finding the 'best' estimates rather than quantifying the predictive uncertainty. This essay presents a compendium of reasons for probabilistic forecasting of hydrological variates. Probabilistic forecasts are scientifically more honest, enable risk-based warnings of floods, enable rational decision making, and offer additional economic benefits. The growing demand for information about risk and the rising capability to quantify predictive uncertainties create an unparalleled opportunity for the hydrological profession to dramatically enhance the forecasting paradigm.

National health expenditures, 1990

PubMed Central

Levit, Katharine R.; Lazenby, Helen C.; Cowan, Cathy A.; Letsch, Suzanne W.

1991-01-01

During 1990, health expenditures as a share of gross national product rose to 12.2 percent, up from 11.6 percent in 1989. This dramatic increase is the second largest increase in the past three decades. The national health expenditure estimates presented in this article document rapidly rising health care costs and provide a context for understanding the health care financing crisis facing the Nation today. The 1990 national health expenditures incorporate the most recently available data. They differ from historical estimates presented in the preceding article. The length of time and complicated process of producing projections required use of 1989 national health expenditures—data available prior to the completion of the 1990 estimates presented here. PMID:10114934

Transmission Electron Microscopy for Nanomedicine: Novel Applications for Long-established Techniques

PubMed Central

2016-01-01

During the last twenty years, the research in nanoscience and nanotechnology has dramatically increased and, in the last decade, the interest has progressively been oriented towards biomedical applications, giving rise to a new field termed nanomedicine. Transmission electron microscopy is a valuable technique not only for the thorough physico-chemical characterization of newly synthesized nanoparticulates, but especially to explore the effects of nanocomposites on biological systems, providing essential information for the development of efficient therapeutic and diagnostic strategies. Thus, for the progress of nanotechnology in the biomedical field, experts in cell biology, histochemistry and ultramicroscopy should always support the chemists, physicists and pharmacologists engaged in the synthesis and characterization of innovative nanoconstructs. PMID:28076938

Micro-structured femtosecond laser assisted FBG hydrogen sensor.

PubMed

Karanja, Joseph Muna; Dai, Yutang; Zhou, Xian; Liu, Bin; Yang, Minghong

2015-11-30

We discuss hydrogen sensors based on fiber Bragg gratings (FBGs) micro-machined by femtosecond laser to form microgrooves and sputtered with Pd/Ag composite film. The atomic ratio of the two metals is controlled at Pd:Ag = 3:1. At room temperature, the hydrogen sensitivity of the sensor probe micro-machined by 75 mW laser power and sputtered with 520 nm of Pd/Ag film is 16.5 pm/%H. Comparably, the standard FBG hydrogen sensitivity becomes 2.5 pm/%H towards the same 4% hydrogen concentration. At an ambient temperature of 35°C, the processed sensor head has a dramatic rise in hydrogen sensitivity. Besides, the sensor shows good response and repeatability during hydrogen concentration test.

Topological phenomena in classical optical networks

PubMed Central

Shi, T.; Kimble, H. J.; Cirac, J. I.

2017-01-01

We propose a scheme to realize a topological insulator with optical-passive elements and analyze the effects of Kerr nonlinearities in its topological behavior. In the linear regime, our design gives rise to an optical spectrum with topological features and where the bandwidths and bandgaps are dramatically broadened. The resulting edge modes cover a very wide frequency range. We relate this behavior to the fact that the effective Hamiltonian describing the system’s amplitudes is long range. We also develop a method to analyze the scheme in the presence of a Kerr medium. We assess robustness and stability of the topological features and predict the presence of chiral squeezed fluctuations at the edges in some parameter regimes. PMID:29073093

MTBE, Oxygenates, and Motor Gasoline (Short-Term Energy Outlook Supplement October 1999)

EIA Publications

1999-01-01

The blending of methyl tertiary butyl ether (MTBE) into motor gasoline has increased dramatically since it was first produced 20 years ago. MTBE usage grew in the early 1980's in response to octane demand resulting initially from the phaseout of lead from gasoline and later from rising demand for premium gasoline. The oxygenated gasoline program stimulated an increase in MTBE production between 1990 and 1994. MTBE demand increased from 83,000 in 1990 to 161,000 barrels per day in 1994. The reformulated gasoline (RFG) program provided a further boost to oxygenate blending. The MTBE contained in motor gasoline increased to 269,000 barrels per day by 1997.

Skills, education, and the rise of earnings inequality among the "other 99 percent".

PubMed

Autor, David H

2014-05-23

The singular focus of public debate on the "top 1 percent" of households overlooks the component of earnings inequality that is arguably most consequential for the "other 99 percent" of citizens: the dramatic growth in the wage premium associated with higher education and cognitive ability. This Review documents the central role of both the supply and demand for skills in shaping inequality, discusses why skill demands have persistently risen in industrialized countries, and considers the economic value of inequality alongside its potential social costs. I conclude by highlighting the constructive role for public policy in fostering skills formation and preserving economic mobility. Copyright © 2014, American Association for the Advancement of Science.

On-chip phase-change photonic memory and computing

NASA Astrophysics Data System (ADS)

Cheng, Zengguang; Ríos, Carlos; Youngblood, Nathan; Wright, C. David; Pernice, Wolfram H. P.; Bhaskaran, Harish

2017-08-01

The use of photonics in computing is a hot topic of interest, driven by the need for ever-increasing speed along with reduced power consumption. In existing computing architectures, photonic data storage would dramatically improve the performance by reducing latencies associated with electrical memories. At the same time, the rise of `big data' and `deep learning' is driving the quest for non-von Neumann and brain-inspired computing paradigms. To succeed in both aspects, we have demonstrated non-volatile multi-level photonic memory avoiding the von Neumann bottleneck in the existing computing paradigm and a photonic synapse resembling the biological synapses for brain-inspired computing using phase-change materials (Ge2Sb2Te5).

Male prostitution in the twentieth century: pseudohomosexuals, hoodlum homosexuals, and exploited teens.

PubMed

Kaye, Kerwin

2003-01-01

Male prostitution altered its form dramatically over the course of the twentieth century. While some of these changes relate to economics and general cultural shifts (the Depression of the 1930s, the rise of a counterculture during the 1960s and 70s), some of the most important changes have arisen in response to transformations in the idea of "homosexuality," and the growing influence this idea had within middle-class and then working-class culture. This essay identifies the diverse forms male prostitution has taken since the late-Victorian period, and also examines the way in which male prostitution has been written about by various commentators in different eras.

Does the CRH binding protein shield the anterior pituitary from placental CRH?

PubMed

Thomson, M

1998-12-01

Corticotropin releasing factor (CRH) is released from the hypothalamus and travels to the anterior pituitary where it stimulates the release of adrenocorticotropin (ACTH). In turn, ACTH travels through the blood and stimulates the release of cortisol from the adrenal. The placenta is also a source of CRH and is responsible for the dramatic rises in CRH plasma levels in the third trimester of pregnancy. A CRH binding protein may stop placental CRH from overstimulating the pituitary and may contribute to the reason that pregnant women show only mildly elevated levels of ACTH in the blood. There is evidence to suggest, however, that the CRH binding protein does not completely shield the corticotrope from placental CRH.

Analysis of global impacts of sea-level rise: a case study of flooding

NASA Astrophysics Data System (ADS)

Nicholls, Robert J.

Analysis of the response to climate change and sea-level rise requires a link from climate change science to the resulting impacts and their policy implications. This paper explores the impacts of sea-level rise, particularly increased coastal flooding due to storm surges. In particular, it asks the simple question “how much will projected global sea-level rise exacerbate coastal flood problems, if ignored?” This is an important question to the intergovernmental process considering climate change. Further many countries presently ignore sea-level rise in long-term coastal planning, even though global sea levels are presently slowly rising. Using the model of Nicholls et al. [Global Environmental Change 9 (1999) S69], the analysis considers the flood impacts of sea-level rise on an “IS92a world” based on a consistent set of scenarios of global-mean sea-level rise, subsidence (where appropriate), coastal population change (usually increase), and flood defence standards (derived from GDP/capita). Two of the protection scenarios consider the possible upgrade of flood defences, but no allowance for global-mean sea-level rise is allowed to ensure consistency with the question being investigated. This model has been validated against national- and regional-scale assessments indicating that the relative results are reasonable, and the absolute results are of the right order of magnitude. The model estimates that 10 million people experienced flooding annually in 1990. It also predicts that the incidence of flooding will change without sea-level rise due to changes to the other three factors. Taking the full range of scenarios considered by 2100 the number of people flooded could be from 0.4 to 39 million/year. All the sea-level rise scenarios would cause an increase in flooding during the 21st century if measures to adapt to sea-level rise are not taken. However, there are significant uncertainties and the number of people who are estimated to experience flooding in 2100 is 16-388 million for the mid (55-cm) global-mean sea-level rise scenarios, and up to 510 million people/year for the high (96-cm) scenario. These results suggest that sea-level rise could be a significant problem if it is ignored, and hence it needs to be considered within the policy process considering climate change in terms of mitigation (reducing greenhouse gas emissions) and adaptation (improved coastal management and planning) needs.

HIV health crisis and African Americans: a cultural perspective.

PubMed

Plowden, K; Miller, J L; James, T

2000-01-01

While incidence of new HIV infections have decreased in the overall population, the numbers continue to rise in African-Americans creating a serious health emergency. Studies seem to imply that part of the rise is due to HIV beliefs and high risk behaviors among African Americans. Due to certain societal factors, African Americans appear to be at greater risk for contracting the virus. This article will examine these critical social factors and their impact on this current state of emergency in the African American community using Leininger's theory of Culture Care and Universality. Implications for health providers are also addressed.

Natural rubber latex allergy after 12 years: recommendations and perspectives.

PubMed

Charous, B Lauren; Blanco, Carlos; Tarlo, Susan; Hamilton, Robert G; Baur, Xaver; Beezhold, Donald; Sussman, Gordon; Yunginger, John W

2002-01-01

Natural rubber latex (NRL) allergy is a "new" illness whose prevalence reached epidemic proportions in highly exposed populations during the last decade. In children with spina bifida and in patients exposed to NRL during radiologic procedures, institution of prophylactic safety measures has had demonstrable effects in preventing allergic reactions. The risk of NRL allergy appears to be largely linked to occupational exposure, and NRL-associated occupational asthma is due almost solely to powdered latex glove use. Prevalence of NRL-allergic sensitization in the general population is quite low; several studies of young adults demonstrate rates of positive skin test results that are less than 1%. After occupational exposure, rates of sensitization and NRL-induced asthma rise dramatically in individuals using powdered NRL gloves but not in individuals using powder-free gloves. Airborne NRL is dependent on the use of powdered NRL gloves; conversion to non-NRL or nonpowdered NRL substitutes results in predictable rapid disappearance of detectable levels of aeroallergen. For these reasons, adoption of the following institutional policies designed to prevent new cases of NRL allergy and maximize safety is recommended: (1) NRL gloves should be used only as mandated by accepted Standard Precautions; (2) only nonpowdered, nonsterile NRL gloves should be used; and (3) nonpowdered, sterile NRL gloves are preferred for use. Low-protein powdered, sterile gloves may be used, but only in conjunction with an ongoing assessment for development of allergic reactions.

Epidemiology and natural history of gastro-oesophageal reflux disease.

PubMed

Spechler, S J

1992-01-01

Epidemiological studies of gastro-oesophageal reflux disease (GORD) are confounded by the lack of a standardized definition and a diagnostic 'gold-standard' for the disorder. In Western countries, 20-40% of the adult population experience heartburn, which is the cardinal symptom of GORD, but only some 2% of adults have objective evidence of reflux oesophagitis. The incidence of GORD increases with age, rising dramatically after 40 years of age. There is also wide geographical variation in prevalence. Complications, including oesophageal ulcer and stricture, and Barrett's oesophagus, are found in up to 20% of patients with verified reflux oesophagitis. The signs and symptoms of GORD often wax and wane in intensity, and spontaneous remissions have been reported. In most cases, however, GORD is a chronic condition that returns shortly after discontinuing therapy. Although GORD causes substantial morbidity, the annual mortality rate due to GORD is very low (approximately 1 death per 100,000 patients), and even severe GORD has no apparent effect on longevity, although the quality of life can be significantly impaired. There are data to suggest that the use of non-steroidal anti-inflammatory drugs (NSAIDs) contributes to oesophagitis and stricture formation in patients with GORD. Although these data are not conclusive, it seems prudent, if possible, to avoid the use of NSAIDs in patients with GORD, particularly those with oesophageal stricture.

BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation

PubMed Central

Mitsiadis, Thimios A.; Graf, Daniel; Luder, Hansueli; Gridley, Thomas; Bluteau, Gilles

2010-01-01

The Notch signalling pathway is an evolutionarily conserved intercellular signalling mechanism that is essential for cell fate specification and proper embryonic development. We have analysed the expression, regulation and function of the jagged 2 (Jag2) gene, which encodes a ligand for the Notch family of receptors, in developing mouse teeth. Jag2 is expressed in epithelial cells that give rise to the enamel-producing ameloblasts from the earliest stages of tooth development. Tissue recombination experiments showed that its expression in epithelium is regulated by mesenchyme-derived signals. In dental explants cultured in vitro, the local application of fibroblast growth factors upregulated Jag2 expression, whereas bone morphogenetic proteins provoked the opposite effect. Mice homozygous for a deletion in the Notch-interaction domain of Jag2 presented a variety of severe dental abnormalities. In molars, the crown morphology was misshapen, with additional cusps being formed. This was due to alterations in the enamel knot, an epithelial signalling structure involved in molar crown morphogenesis, in which Bmp4 expression and apoptosis were altered. In incisors, cytodifferentiation and enamel matrix deposition were inhibited. The expression of Tbx1 in ameloblast progenitors, which is a hallmark for ameloblast differentiation and enamel formation, was dramatically reduced in Jag2−/− teeth. Together, these results demonstrate that Notch signalling mediated by Jag2 is indispensable for normal tooth development. PMID:20685737

Climate-induced landslide reactivation at the edge of the Most Basin (Czech Republic) - progress towards better landslide prediction

NASA Astrophysics Data System (ADS)

Burda, J.; Hartvich, F.; Valenta, J.; Smítka, V.; Rybář, J.

2013-02-01

The catastrophic landslide at Eisenberg in North Bohemia was reactivated during January 2011. This study integrates a range of geoscientific evidence in order to constrain the spatial and temporal development of this reactivation. It has investigated long-term geodetic measurements to assess the morphological development of the site over the last two decades. There is evidence to suggest that, over this period, the site had been subjected to progressive deformation caused by the collapse of an old mine gallery. However, climatic data show that the reactivation itself was triggered by a dramatic rise in the water table induced by rapid snowmelt during a period of winter warming. Furthermore, geomorphological mapping has been used to characterise the morphology of the reactivated landslide and geophysical profiling has been used to analyse its internal structure. The results show that fissures are continuing to develop above the reactivated landslide scarp while highly saturated stiff-fissured claystones provide an incipient slide plane. The application of laser scanning has shown minimal evidence for ongoing landslide activity. It is, however, clear that future landslide events will occur here due to the favourable lithological, structural, and geotechnical conditions. Finally, we propose that future landslide activity at the site may be predicted by the height of water table as this defines theoretical pore pressure at the depth of the shear plane.

Meltwater pulse recorded in Last Interglacial mollusk shells from Bermuda

NASA Astrophysics Data System (ADS)

Winkelstern, Ian Z.; Rowe, Mark P.; Lohmann, Kyger C.; Defliese, William F.; Petersen, Sierra V.; Brewer, Aaron W.

2017-02-01

The warm climate of Bermuda today is modulated by the nearby presence of the Gulf Stream current. However, iceberg scours in the Florida Strait and the presence of ice-rafted debris in Bermuda Rise sediments indicate that, during the last deglaciation, icebergs discharged from the Laurentide Ice Sheet traveled as far south as subtropical latitudes. We present evidence that an event of similar magnitude affected the subtropics during the Last Interglacial, potentially due to melting of the Greenland Ice Sheet. Using the clumped isotope paleothermometer, we found temperatures 10°C colder and seawater δ18O values 2‰ lower than modern in Last Interglacial Cittarium pica shells from Grape Bay, Bermuda. In contrast, Last Interglacial shells from Rocky Bay, Bermuda, record temperatures only slightly colder and seawater δ18O values similar to modern, likely representing more typical Last Interglacial conditions in Bermuda outside of a meltwater event. The significantly colder ocean temperatures observed in Grape Bay samples illustrate the extreme sensitivity of Bermudian climate to broad-scale ocean circulation changes. They indicate routine meltwater transport in the North Atlantic to near-equatorial latitudes, which would likely have resulted in disruption of the Atlantic Meridional Overturning Circulation. These data demonstrate that future melting of the Greenland Ice Sheet, a potential source of the Last Interglacial meltwater event, could have dramatic climate effects outside of the high latitudes.

Macular Carotenoid Supplementation Improves Visual Performance, Sleep Quality, and Adverse Physical Symptoms in Those with High Screen Time Exposure

PubMed Central

Stringham, James M.; Stringham, Nicole T.; O’Brien, Kevin J.

2017-01-01

The dramatic rise in the use of smartphones, tablets, and laptop computers over the past decade has raised concerns about potentially deleterious health effects of increased “screen time” (ST) and associated short-wavelength (blue) light exposure. We determined baseline associations and effects of 6 months’ supplementation with the macular carotenoids (MC) lutein, zeaxanthin, and mesozeaxanthin on the blue-absorbing macular pigment (MP) and measures of sleep quality, visual performance, and physical indicators of excessive ST. Forty-eight healthy young adults with at least 6 h of daily near-field ST exposure participated in this placebo-controlled trial. Visual performance measures included contrast sensitivity, critical flicker fusion, disability glare, and photostress recovery. Physical indicators of excessive screen time and sleep quality were assessed via questionnaire. MP optical density (MPOD) was assessed via heterochromatic flicker photometry. At baseline, MPOD was correlated significantly with all visual performance measures (p < 0.05 for all). MC supplementation (24 mg daily) yielded significant improvement in MPOD, overall sleep quality, headache frequency, eye strain, eye fatigue, and all visual performance measures, versus placebo (p < 0.05 for all). Increased MPOD significantly improves visual performance and, in turn, improves several undesirable physical outcomes associated with excessive ST. The improvement in sleep quality was not directly related to increases in MPOD, and may be due to systemic reduction in oxidative stress and inflammation. PMID:28661438

Macular Carotenoid Supplementation Improves Visual Performance, Sleep Quality, and Adverse Physical Symptoms in Those with High Screen Time Exposure.

PubMed

Stringham, James M; Stringham, Nicole T; O'Brien, Kevin J

2017-06-29

The dramatic rise in the use of smartphones, tablets, and laptop computers over the past decade has raised concerns about potentially deleterious health effects of increased "screen time" (ST) and associated short-wavelength (blue) light exposure. We determined baseline associations and effects of 6 months' supplementation with the macular carotenoids (MC) lutein, zeaxanthin, and mesozeaxanthin on the blue-absorbing macular pigment (MP) and measures of sleep quality, visual performance, and physical indicators of excessive ST. Forty-eight healthy young adults with at least 6 h of daily near-field ST exposure participated in this placebo-controlled trial. Visual performance measures included contrast sensitivity, critical flicker fusion, disability glare, and photostress recovery. Physical indicators of excessive screen time and sleep quality were assessed via questionnaire. MP optical density (MPOD) was assessed via heterochromatic flicker photometry. At baseline, MPOD was correlated significantly with all visual performance measures ( p < 0.05 for all). MC supplementation (24 mg daily) yielded significant improvement in MPOD, overall sleep quality, headache frequency, eye strain, eye fatigue, and all visual performance measures, versus placebo ( p < 0.05 for all). Increased MPOD significantly improves visual performance and, in turn, improves several undesirable physical outcomes associated with excessive ST. The improvement in sleep quality was not directly related to increases in MPOD, and may be due to systemic reduction in oxidative stress and inflammation.

Genotypic effects of elevated CO[sub 2] on fecundity in an annual weed (wild radish, Raphanus raphanistrum)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curtis, P.S.; Snow, A.A.

1993-06-01

Rising atmospheric CO[sub 2] levels may lead to microevolutionary change in native plant populations. To test for within-population variation in genetic responses to elevated p(CO[sub 2]), we exposed five paternal sibships of wild radish to ambient and 2X ambient (700 [mu]bar) p(CO[sub 2]) in 3 m open top chambers for an entre growing season. Seeds were planted singly in 2.5 1 pots filled with locally derived, low fertility soil (160 plants per CO[sub 2] treatment). Net CO[sub 2] assimilation increased 25% in vegetative plants and 48% in reproductive plants growing at elevated p(CO[sub 2]). Every flower was hand-pollinated to mimicmore » natural pollination levels. Lifetime fecundity was greater in the elevated CO[sub 2] treatment, but the magnitude of this effect differed dramatically among paternal sibships: seed production increased 13% overall, yet among paternal sibships seed production varied between 0% and 50% more seeds in elevated p(CO[sub 2]) as compared to ambient. Our results suggest that natural selection can occur due to genotypic differences in the CO[sub 2] response. This process should be considered in estimates of long-term effects of elevated p(CO[sub 2]), especially with regard to anticipated increases in primary productivity.« less

Dramatic change of the recurrence time and outburst parameters of the intermediate polar GK Persei

NASA Astrophysics Data System (ADS)

Šimon, V.

2002-02-01

This analysis has shown that the intermediate polar GK Per experienced a very striking evolution. Its outbursts became wider and brighter in the last five decades. These changes were accompanied by striking variations of the recurrence time T_C, from 385 days within the years 1948-1967 to 890 days in 1970. Nowadays, T_C displays a strong trend of linear increase. Decrease of irradiation of the disk by the WD, combined with the decrease of viscosity, offers a plausible explanation. It is argued that variations of the mass transfer rate are unlikely to play a major role. The morphology of the outburst light curves in the optical and the X-ray region is also studied. The decay branch in the optical remains remarkably similar for all the events while the largest changes of the light curve occur in the rising branch. This can be explained if the thermal instability may start at different distances from the disk center. The quiescent level of brightness does not display any secular trend in recent decades but a wave on the time scale of about 30 years with the full amplitude of 0.3 m_v, probably due to activity of the cool star, is detected. This research has made use of the AFOEV database, operated at CDS, France, and the observations provided by the ASM/RXTE team.

Making the Blue Zones: Neoliberalism and nudges in public health promotion.

PubMed

Carter, Eric D

2015-05-01

This paper evaluates the ideological and political origins of a place-based and commercial health promotion effort, the Blue Zones Project (BZP), launched in Iowa in 2011. Through critical discourse analysis, I argue that the BZP does reflect a neoliberalization of public health, but as an "actually existing neoliberalism" it emerges from a specific policy context, including dramatic health sector policy changes due to the national Affordable Care Act, also known as Obamacare; a media discourse of health crisis for an aging Midwestern population; and an effort to refashion Iowa cities as sites of healthy and active living, to retain and attract a creative class of young entrepreneurs. The BZP employs many well-known mechanisms of neoliberal governance: the public-private partnership; competition among communities for "public" funds; promotion of an apolitical discourse on individual responsibility and ownership of health; decentralizing governance to the "community" level; and marketing, branding, and corporate sponsorship of public projects. The BZP exemplifies the process of "neoliberal governmentality," by which individuals learn to govern themselves and their "life projects" in line with a market-based rationality. However, with its emphasis on "nudging" individuals towards healthy behaviors through small changes in the local environment, the BZP reflects the rise of "libertarian paternalism," a variant of neoliberalism, as a dominant ideology underlying contemporary health promotion efforts. Copyright © 2015 Elsevier Ltd. All rights reserved.

Breakdown in helium in high-voltage open discharge with subnanosecond current front rise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schweigert, I. V., E-mail: ischweig@itam.nsc.ru; Alexandrov, A. L.; Bokhan, P. A.

Investigations of high-voltage open discharge in helium have shown a possibility of generation of current pulses with subnanosecond front rise, due to ultra-fast breakdown development. The open discharge is ignited between two planar cathodes with mesh anode in the middle between them. For gas pressure 6 Torr and 20 kV applied voltage, the rate of current rise reaches 500 A/(cm{sup 2} ns) for current density 200 A/cm{sup 2} and more. The time of breakdown development was measured for different helium pressures and a kinetic model of breakdown in open discharge is presented, based on elementary reactions for electrons, ions andmore » fast atoms. The model also includes various cathode emission processes due to cathode bombardment by ions, fast atoms, electrons and photons of resonant radiation with Doppler shift of frequency. It is shown, that the dominating emission processes depend on the evolution of the discharge voltage during the breakdown. In the simulations, two cases of voltage behavior were considered: (i) the voltage is kept constant during the breakdown; (ii) the voltage is reduced with the growth of current. For the first case, the exponentially growing current is maintained due to photoemission by the resonant photons with Doppler-shifted frequency. For the second case, the dominating factor of current growth is the secondary electron emission. In both cases, the subnanosecond rise of discharge current was obtained. Also the effect of gas pressure on breakdown development was considered. It was found that for 20 Torr gas pressure the time of current rise decreases to 0.1 ns, which is in agreement with experimental data.« less

Potential increase in coastal wetland vulnerability to sea-level rise suggested by considering hydrodynamic attenuation effects

PubMed Central

Rodríguez, José F.; Saco, Patricia M.; Sandi, Steven; Saintilan, Neil; Riccardi, Gerardo

2017-01-01

The future of coastal wetlands and their ecological value depend on their capacity to adapt to the interacting effects of human impacts and sea-level rise. Even though extensive wetland loss due to submergence is a possible scenario, its magnitude is highly uncertain due to limited understanding of hydrodynamic and bio-geomorphic interactions over time. In particular, the effect of man-made drainage modifications on hydrodynamic attenuation and consequent wetland evolution is poorly understood. Predictions are further complicated by the presence of a number of vegetation types that change over time and also contribute to flow attenuation. Here, we show that flow attenuation affects wetland vegetation by modifying its wetting-drying regime and inundation depth, increasing its vulnerability to sea-level rise. Our simulations for an Australian subtropical wetland predict much faster wetland loss than commonly used models that do not consider flow attenuation. PMID:28703130

Potential increase in coastal wetland vulnerability to sea-level rise suggested by considering hydrodynamic attenuation effects

NASA Astrophysics Data System (ADS)

Rodríguez, José F.; Saco, Patricia M.; Sandi, Steven; Saintilan, Neil; Riccardi, Gerardo

2017-07-01

The future of coastal wetlands and their ecological value depend on their capacity to adapt to the interacting effects of human impacts and sea-level rise. Even though extensive wetland loss due to submergence is a possible scenario, its magnitude is highly uncertain due to limited understanding of hydrodynamic and bio-geomorphic interactions over time. In particular, the effect of man-made drainage modifications on hydrodynamic attenuation and consequent wetland evolution is poorly understood. Predictions are further complicated by the presence of a number of vegetation types that change over time and also contribute to flow attenuation. Here, we show that flow attenuation affects wetland vegetation by modifying its wetting-drying regime and inundation depth, increasing its vulnerability to sea-level rise. Our simulations for an Australian subtropical wetland predict much faster wetland loss than commonly used models that do not consider flow attenuation.

Implications of sea-level rise in a modern carbonate ramp setting

NASA Astrophysics Data System (ADS)

Lokier, Stephen W.; Court, Wesley M.; Onuma, Takumi; Paul, Andreas

2018-03-01

This study addresses a gap in our understanding of the effects of sea-level rise on the sedimentary systems and morphological development of recent and ancient carbonate ramp settings. Many ancient carbonate sequences are interpreted as having been deposited in carbonate ramp settings. These settings are poorly-represented in the Recent. The study documents the present-day transgressive flooding of the Abu Dhabi coastline at the southern shoreline of the Arabian/Persian Gulf, a carbonate ramp depositional system that is widely employed as a Recent analogue for numerous ancient carbonate systems. Fourteen years of field-based observations are integrated with historical and recent high-resolution satellite imagery in order to document and assess the onset of flooding. Predicted rates of transgression (i.e. landward movement of the shoreline) of 2.5 m yr- 1 (± 0.2 m yr- 1) based on global sea-level rise alone were far exceeded by the flooding rate calculated from the back-stepping of coastal features (10-29 m yr- 1). This discrepancy results from the dynamic nature of the flooding with increased water depth exposing the coastline to increased erosion and, thereby, enhancing back-stepping. A non-accretionary transgressive shoreline trajectory results from relatively rapid sea-level rise coupled with a low-angle ramp geometry and a paucity of sediments. The flooding is represented by the landward migration of facies belts, a range of erosive features and the onset of bioturbation. Employing Intergovernmental Panel on Climate Change (Church et al., 2013) predictions for 21st century sea-level rise, and allowing for the post-flooding lag time that is typical for the start-up of carbonate factories, it is calculated that the coastline will continue to retrograde for the foreseeable future. Total passive flooding (without considering feedback in the modification of the shoreline) by the year 2100 is calculated to likely be between 340 and 571 m with a flooding rate of 3.40-8.64 m yr- 1. However, adopting the observation that global sea-level rise only accounts for 15% of the recorded shoreline retreat, this figure rises dramatically to a total likely dynamic flooding (considering modifications to the shoreline) of between 2.3 and 3.8 km. Loss of microbial and mangal habitats will subject the exposed shoreline to increasing erosion. Shoreline retreat will threaten existing coastal infrastructure.

Sea-level rise: towards understanding local vulnerability

NASA Astrophysics Data System (ADS)

Rahmstorf, Stefan

2012-06-01

Projections of global sea-level rise into the future have become more pessimistic over the past five years or so. A global rise by more than one metre by the year 2100 is now widely accepted as a serious possibility if greenhouse gas emissions continue unabated. That is witnessed by the scientific assessments that were made since the last IPCC report was published in 2007. The Delta Commission of the Dutch government projected up to 1.10 m as a 'high-end' scenario (Vellinga et al 2009). The Scientific Committee on Antarctic Research (SCAR) projected up to 1.40 m (Scientific Committee on Antarctic Research 2009), and the Arctic Monitoring and Assessment Programme (AMAP) gives a range of 0.90-1.60 m in its 2011 report (Arctic Monitoring and Assessment Programme 2011). And recently the US Army Corps of Engineers recommends using a 'low', an 'intermediate' and a 'high' scenario for global sea-level rise when planning civil works programmes, with the high one corresponding to a 1.50 m rise by 2100 (US Army Corps of Engineers 2011). This more pessimistic view is based on a number of observations, most importantly perhaps the fact that sea level has been rising at least 50% faster in the past decades than projected by the IPCC (Rahmstorf et al 2007, IPCC 2007). Also, the rate of rise (averaged over two decades) has accelerated threefold, from around 1 mm yr-1 at the start of the 20th century to around 3 mm yr-1 over the past 20 years (Church and White 2006), and this rate increase closely correlates with global warming (Rahmstorf et al 2011). The IPCC projections, which assume almost no further acceleration in the 20th century, thus look less plausible. And finally the observed net mass loss of the two big continental ice sheets (Van den Broeke et al 2011) calls into question the assumption that ice accumulation in Antarctica would largely balance ice loss from Greenland in the course of further global warming (IPCC 2007). With such a serious sea-level rise on the horizon, experts are increasingly looking at its potential impacts on coasts to facilitate local adaptation planning. This is a more complex issue than one might think, because different stretches of coast can be affected in very different ways. First of all, the sea-level response to global warming will not be globally uniform, since factors like changes in ocean currents (Levermann et al 2005) and the changing gravitational pull of continental ice (Mitrovica et al 2001) affect the local rise. Secondly, superimposed on the climatic trend is natural variability in sea level, which regionally can be as large as the climatic signal on multi-decadal timescales. Over the past decades, sea level has dropped in sizable parts of the world ocean, although it has of course risen in global mean (IPCC 2007). Thirdly, local land uplift or subsidence affects the local sea-level change relative to the coast, both for natural reasons (post-glacial isostatic adjustment centred on regions that were covered by ice sheets during the last ice age) and artificial ones (e.g., extraction of water or oil as in the Gulf of Mexico). Finally, local vulnerability to sea-level rise depends on many factors. Two interesting new studies in this journal (Tebaldi et al 2012, Strauss et al 2012) make important steps towards understanding sea-level vulnerability along the coasts of the United States, with methods that could also be applied elsewhere. The first, by Strauss and colleagues, merges high-resolution topographic data and a newly available tidal model together with population and housing data in order to estimate what land area and population would be at risk given certain increments in sea level. The results are mapped and tabulated at county and city level. They reveal the 'hot spots' along the US coast where sea-level rise is of the highest concern because of large populations living near the high-tide line: New York City and Long Island; the New Jersey shore; the Norfolk, Virginia, area; near Charleston, South Carolina; coastal cities across Florida, especially its southeast and the Tampa area; New Orleans; the San Francisco Bay Area and San Joaquin Delta; and greater Los Angeles. Overall, 3.7 million people across the US are estimated to live within 1 m of the present high-tide line. The second paper, by Tebaldi et al, specifically looks at storm surges and how their frequency is expected to change along the US coastline in the coming four decades due to rising sea levels. They first estimate future local sea-level rise relative to the land by combining the observed local trend of the past fifty years with a future acceleration due to global warming as estimated by a semi-empirical model (Vermeer and Rahmstorf 2009). Then they use past storm surge statistics for many different locations and shift the return level curves according to the projected sea-level rise. The authors find that by mid-century, in some locations what is now a once-per-century flooding event could become an annual event. Those are exceptional places—but at about a third of the sites investigated, a century flood could become a once-per-decade flood. Of course, many of these events need not have dramatic impacts: in fact, locations where rare floods are quite small in amplitude (and hence presumably modest in their impacts) are precisely those where the return period decreases most dramatically. In a place where the once-per-century flood is only 50 cm higher than the annual flood, a typical 30 cm rise in sea level makes a bigger difference than one in a place where the century flood is 2 m higher than the annual flood. Nevertheless, the expected large changes in return periods and return levels of storm surges clearly demonstrate that accounting for accelerating sea-level rise is vital in the planning and design of coastal infrastructure. But most importantly, these studies highlight the fact that the modern world, with many millions of people living right by the coast, is highly vulnerable to even modest sea-level rise. Losing just 1% of the present continental ice would raise sea level globally by about 75 cm—a tiny amount in the perspective of palaeoclimate history, e.g. the 120 m rise at the end of the last ice age, but a large amount in terms of impacts on human society. We should do everything we can to limit global warming and thereby sea-level rise to a manageable level. References Arctic Monitoring and Assessment Programme 2011 Snow, Water, Ice and Permafrost in the Arctic (Oslo: AMAP) Church J A and White N J 2006 A 20th century acceleration in global sea-level rise Geophys. Res. Lett. 33 L01602 IPCC 2007 Climate Change 2007: The Physical Science Basis. The Fourth Assessment Report of the Intergovernmental Panel on Climate Change ed S Solomon et al (Cambridge: Cambridge University Press) Levermann A, Griesel A, Hofmann M, Montoya M and Rahmstorf S 2005 Dynamic sea level changes following changes in the thermohaline circulation Clim. Dyn. 24 347-54 Mitrovica J X, Tamisiea M E, Davis J L and Milne G A 2001 Recent mass balance of polar ice sheets inferred from patterns of global sea-level change Nature 409 1026-9 Rahmstorf S, Cazenave A, Church J A, Hansen J E, Keeling R F, Parker D E and Somerville C J 2007 Recent climate observations compared to projections Science 316 709 Rahmstorf S, Perrette M and Vermeer M 2011 Testing the robustness of semi-empirical sea level projections Clim. Dyn. at press (doi:10.1007/s00382-011-1226-7) Scientific Committee on Antarctic Research 2009 Antarctic Climate Change and the Environment (Cambridge: Scott Polar Research Institute) Strauss B, Ziemlinski R, Weiss J and Overpeck J T 2012 Tidally-adjusted estimates of topographic vulnerability to sea level rise and flooding for the contiguous United States Environ. Res. Lett. 7 014033 Tebaldi C, Strauss B and Zervas C 2012 Modelling sea level rise impacts on storm surges along US coasts Environ. Res. Lett. 7 014032 US Army Corps of Engineers 2011 Sea-Level Change Considerations for Civil Works Programs (Washington, DC: Department of the Army) Van den Broeke M R, Bamber J, Lenaerts J and Rignot E 2011 Ice sheets and sea level: thinking outside the box Sur. Geophys. 32 495-505 Vellinga P, Katsman C A, Sterl A and Beersma J J 2009 Exploring high-end climate change scenarios for flood protection of the Netherlands International Scientific Assessment Carried out at the Request of the Delta Committee (De Bilt: KNMI) Vermeer M and Rahmstorf S 2009 Global sea level linked to global temperature Proc. Natl Acad. Sci. USA 106 21527-32

Spatial patterns of composition in tidal wetland plant and algal assemblages in Oregon: Implications for wetland vulnerability to sea-level rise

EPA Science Inventory

Plants and algae mediate important ecosystem processes in coastal marshes and swamps. These assemblages are structured in part by estuarine environmental gradients such as tidal elevation and salinity. Such gradients are likely to change with sea-level rise (SLR) due to global cl...

Investigating sea level rise due to global warming in the teaching laboratory using Archimedes’ principle

NASA Astrophysics Data System (ADS)

Hughes, Stephen; Pearce, Darren

2015-11-01

A teaching laboratory experiment is described that uses Archimedes’ principle to precisely investigate the effect of global warming on the oceans. A large component of sea level rise is due to the increase in the volume of water due to the decrease in water density with increasing temperature. Water close to 0 °C is placed in a beaker and a glass marble hung from an electronic balance immersed in the water. As the water warms, the weight of the marble increases as the water is less buoyant due to the decrease in density. In the experiment performed in this paper a balance with a precision of 0.1 mg was used with a marble 40.0 cm3 and mass of 99.3 g, yielding water density measurements with an average error of -0.008 ± 0.011%.

Building a sustainable GIS framework for supporting a tribal transportation problem.

DOT National Transportation Integrated Search

2017-03-01

Due to the recent oil boom, the Fort Berthold Reservation has experienced a dramatic increase in highway and local traffic. To support energy transportation and provide safe roads, the reservation needs cost-efficient and effective transportation pla...

Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise.

PubMed

Saha, Supriya K; Zhu, Andrew X; Fuchs, Charles S; Brooks, Gabriel A

2016-05-01

Challenges in the diagnosis and classification of cholangiocarcinoma have made it difficult to quantify the true incidence of this highly aggressive malignancy. We analyzed the Surveillance, Epidemiology, and End Results data to assess long-term trends in the age-standardized incidence of intrahepatic and extrahepatic cholangiocarcinoma between 1973 and 2012, correcting for systematic coding errors. Because intrahepatic cholangiocarcinoma (ICC) may frequently be misdiagnosed as cancer of unknown primary (CUP), we also analyzed trends in the incidence of CUP. Between 1973 and 2012, the reported U.S. incidence of ICC increased from 0.44 to 1.18 cases per 100,000, representing an annual percentage change (APC) of 2.30%; this trend has accelerated during the past decade to an APC of 4.36%. The incidence of extrahepatic cholangiocarcinoma increased modestly from 0.95 to 1.02 per 100,000 during the 40-year period (APC, 0.14%). The incidence of CUP with histologic features potentially consistent with cholangiocarcinoma decreased by 51% between 1973 and 2012 (APC, -1.87%), whereas the incidence of CUP with squamous or nonepithelial histologic features increased modestly (APC, 0.42%). The recognized incidence of ICC in the U.S. continues to rise, whereas the incidence of ECC is stable. The incidence of CUP has fallen dramatically during the same time period. Clinical distinctions between cholangiocarcinoma (particularly intrahepatic cholangiocarcinoma [ICC]) and cancer of unknown primary (CUP) can be challenging. Recent discoveries have identified recurrent and potentially targetable genomic abnormalities in ICC, highlighting the importance of improving diagnosis. This study demonstrates that the incidence of ICC is increasing in the U.S., whereas the incidence of extrahepatic cholangiocarcinoma is stable. Concomitantly, the incidence of CUP has declined dramatically, suggesting that improved distinction between ICC and CUP may be a major driver of the increasing recognized incidence of ICC. The increasing incidence of ICC warrants further study of prevention and treatment approaches. ©AlphaMed Press.

Incorporating Infrastructure and Vegetation Effects on Sea Level Rise Predictions in Low-Gradient Coastal Landscapes

NASA Astrophysics Data System (ADS)

Rodriguez, J. F.; Sandi Rojas, S.; Trivisonno, F.; Saco, P. M.; Riccardi, G.

2015-12-01

At the regional and global scales, coastal management and planning for future sea level rise scenarios is typically supported by modelling tools that predict the expected inundation extent. These tools rely on a number of simplifying assumptions that, in some cases, may result in important overestimation or underestimation of the inundation extent. One of such cases is coastal wetlands, where vegetation strongly affects both the magnitude and the timing of inundation. Many coastal wetlands display other forms of flow restrictions due to, for example, infrastructure or drainage works, which also alters the inundation patterns. In this contribution we explore the effects of flow restrictions on inundation patterns under sea level rise conditions in coastal wetlands. We use a dynamic wetland evolution model that not only incorporates the effects of flow restrictions due to culverts, bridges and weirs as well as vegetation, but also considers that vegetation changes as a consequence of increasing inundation. We apply our model to a coastal wetland in Australia and compare predictions of our model to predictions using conventional approaches. We found that some restrictions accentuate detrimental effects of sea level rise while others moderate them. We also found that some management strategies based on flow redistribution that provide short term solution may result more damaging in the long term if sea level rise is considered.

Arabidopsis transcriptional response to extracellular Ca2+ depletion involves a transient rise in cytosolic Ca2+.

PubMed

Wang, Jing; Tergel, Tergel; Chen, Jianhua; Yang, Ju; Kang, Yan; Qi, Zhi

2015-02-01

Ecological evidence indicates a worldwide trend of dramatically decreased soil Ca(2+) levels caused by increased acid deposition and massive timber harvesting. Little is known about the genetic and cellular mechanism of plants' responses to Ca(2+) depletion. In this study, transcriptional profiling analysis helped identify multiple extracellular Ca(2+) ([Ca(2+) ]ext ) depletion-responsive genes in Arabidopsis thaliana L., many of which are involved in response to other environmental stresses. Interestingly, a group of genes encoding putative cytosolic Ca(2+) ([Ca(2+) ]cyt ) sensors were significantly upregulated, implying that [Ca(2+) ]cyt has a role in sensing [Ca(2+) ]ext depletion. Consistent with this observation, [Ca(2+) ]ext depletion stimulated a transient rise in [Ca(2+) ]cyt that was negatively influenced by [K(+) ]ext , suggesting the involvement of a membrane potential-sensitive component. The [Ca(2+) ]cyt response to [Ca(2+) ]ext depletion was significantly desensitized after the initial treatment, which is typical of a receptor-mediated signaling event. The response was insensitive to an animal Ca(2+) sensor antagonist, but was suppressed by neomycin, an inhibitor of phospholipase C. Gd(3+) , an inhibitor of Ca(2+) channels, suppressed the [Ca(2+) ]ext -triggered rise in [Ca(2+) ]cyt and downstream changes in gene expression. Taken together, this study demonstrates that [Ca(2+) ]cyt plays an important role in the putative receptor-mediated cellular and transcriptional response to [Ca(2+) ]ext depletion of plant cells. © 2014 Institute of Botany, Chinese Academy of Sciences.

Diabetes Prevalence in Sweden at Present and Projections for Year 2050

PubMed Central

Andersson, Tomas; Ahlbom, Anders; Carlsson, Sofia

2015-01-01

Background Data on the future diabetes burden in Scandinavia is limited. Our aim was to project the future burden of diabetes in Sweden by modelling data on incidence, prevalence, mortality, and demographic factors. Method To project the future burden of diabetes we used information on the prevalence of diabetes from the national drug prescription registry (adults ≥20 years), previously published data on relative mortality in people with diabetes, and population demographics and projections from Statistics Sweden. Alternative scenarios were created based on different assumptions regarding the future incidence of diabetes. Results Between 2007 and 2013 the prevalence of diabetes rose from 5.8 to 6.8% in Sweden but incidence remained constant at 4.4 per 1000 (2013). With constant incidence and continued improvement in relative survival, prevalence will increase to 10.4% by year 2050 and the number of afflicted individuals will increase to 940 000. Of this rise, 30% is accounted for by changes in the age structure of the population and 14% by improved relative survival in people with diabetes. A hypothesized 1% annual rise in incidence will result in a prevalence of 12.6% and 1 136 000 cases. Even with decreasing incidence at 1% per year, prevalence of diabetes will continue to increase. Conclusion We can expect diabetes prevalence to rise substantially in Sweden over the next 35 years as a result of demographic changes and improved survival among people with diabetes. A dramatic reduction in incidence is required to prevent this development. PMID:26619340

Deep Uncertainties in Sea-Level Rise and Storm Surge Projections: Implications for Coastal Flood Risk Management.

PubMed

Oddo, Perry C; Lee, Ben S; Garner, Gregory G; Srikrishnan, Vivek; Reed, Patrick M; Forest, Chris E; Keller, Klaus

2017-09-05

Sea levels are rising in many areas around the world, posing risks to coastal communities and infrastructures. Strategies for managing these flood risks present decision challenges that require a combination of geophysical, economic, and infrastructure models. Previous studies have broken important new ground on the considerable tensions between the costs of upgrading infrastructure and the damages that could result from extreme flood events. However, many risk-based adaptation strategies remain silent on certain potentially important uncertainties, as well as the tradeoffs between competing objectives. Here, we implement and improve on a classic decision-analytical model (Van Dantzig 1956) to: (i) capture tradeoffs across conflicting stakeholder objectives, (ii) demonstrate the consequences of structural uncertainties in the sea-level rise and storm surge models, and (iii) identify the parametric uncertainties that most strongly influence each objective using global sensitivity analysis. We find that the flood adaptation model produces potentially myopic solutions when formulated using traditional mean-centric decision theory. Moving from a single-objective problem formulation to one with multiobjective tradeoffs dramatically expands the decision space, and highlights the need for compromise solutions to address stakeholder preferences. We find deep structural uncertainties that have large effects on the model outcome, with the storm surge parameters accounting for the greatest impacts. Global sensitivity analysis effectively identifies important parameter interactions that local methods overlook, and that could have critical implications for flood adaptation strategies. © 2017 Society for Risk Analysis.

Diet-related determinants of childhood obesity in urban settings: a comparison between Shanghai and New York.

PubMed

Leung, M M; Fu, H; Agaronov, A; Freudenberg, N

2015-04-01

Over the past three decades, both Shanghai and New York City (NYC), have experienced dramatic rises in childhood obesity rates. Given the role that obesity plays in the aetiology of chronic diseases such as diabetes and heart disease, the elevated rates are a major concern. Despite differences in governance systems and cultures, Shanghai and NYC have experienced rapid industrialization, a growing population and a rise in income inequality. The prevalence of childhood obesity in Shanghai and NYC is greater than their respective national rate. However, the trajectory and development of this epidemic has differed between the cities. The distribution of obesity by race and ethnicity, socio-economic status, sex, and age differs markedly between the two cities. To reduce prevalence and inequities within this complex epidemic requires an understanding of the dynamic changes in living conditions among social groups in each city and the behaviours that are influenced by such changes. By comparing changes in the influences on dietary behaviours, such as food distribution, pricing, gender values, and media and marketing, this highlights opportunities for Shanghai, NYC, and other world cities with high or rising rates of childhood obesity to inform future program and policy initiatives. It reiterates the importance of a comprehensive and multilevel approach that includes action at the individual, family, community, municipal, national, and global levels. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Massive global ozone loss predicted following regional nuclear conflict

PubMed Central

Mills, Michael J.; Toon, Owen B.; Turco, Richard P.; Kinnison, Douglas E.; Garcia, Rolando R.

2008-01-01

We use a chemistry-climate model and new estimates of smoke produced by fires in contemporary cities to calculate the impact on stratospheric ozone of a regional nuclear war between developing nuclear states involving 100 Hiroshima-size bombs exploded in cities in the northern subtropics. We find column ozone losses in excess of 20% globally, 25–45% at midlatitudes, and 50–70% at northern high latitudes persisting for 5 years, with substantial losses continuing for 5 additional years. Column ozone amounts remain near or <220 Dobson units at all latitudes even after three years, constituting an extratropical “ozone hole.” The resulting increases in UV radiation could impact the biota significantly, including serious consequences for human health. The primary cause for the dramatic and persistent ozone depletion is heating of the stratosphere by smoke, which strongly absorbs solar radiation. The smoke-laden air rises to the upper stratosphere, where removal mechanisms are slow, so that much of the stratosphere is ultimately heated by the localized smoke injections. Higher stratospheric temperatures accelerate catalytic reaction cycles, particularly those of odd-nitrogen, which destroy ozone. In addition, the strong convection created by rising smoke plumes alters the stratospheric circulation, redistributing ozone and the sources of ozone-depleting gases, including N2O and chlorofluorocarbons. The ozone losses predicted here are significantly greater than previous “nuclear winter/UV spring” calculations, which did not adequately represent stratospheric plume rise. Our results point to previously unrecognized mechanisms for stratospheric ozone depletion. PMID:18391218

The Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action.

PubMed

Ethgen, O; Beaudart, C; Buckinx, F; Bruyère, O; Reginster, J Y

2017-03-01

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected burden of sarcopenia in the coming years. Age- and gender-specific population projections were retrieved until 2045 from the Eurostat online database (28 European countries). Age- and gender-specific prevalences of sarcopenia were interpolated from a study that compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition. The reported prevalence estimates were interpolated between 65 and 100 years. Interpolated age- and gender-specific estimates of sarcopenia prevalence were then applied to population projections until 2045. Using the definition providing the lowest prevalence estimates, the number of individuals with sarcopenia would rise in Europe from 10,869,527 in 2016 to 18,735,173 in 2045 (a 72.4% increase). This corresponds to an overall prevalence of sarcopenia in the elderly rising from 11.1% in 2016 to 12.9% in 2045. With the definition providing the highest prevalence estimates, the number of individuals with sarcopenia would rise from 19,740,527 in 2016 to 32,338,990 in 2045 (a 63.8% increase), corresponding to overall prevalence rates in the elderly of 20.2% and 22.3% for 2016 and 2045, respectively. We showed that the number of sarcopenic patients will dramatically increase in the next 30 years, making consequences of muscle wasting a major public health issue.

Effect of LED and Argon Laser on Degree of Conversion and Temperature Rise of Hybrid and Low Shrinkage Composite Resins

PubMed Central

Pahlevan, Ayob; Tabatabaei, Masumeh Hasani; Arami, Sakineh; Valizadeh, Sara

2016-01-01

Objectives: Different light curing units are used for polymerization of composite resins. The aim of this study was to evaluate the degree of conversion (DC) and temperature rise in hybrid and low shrinkage composite resins cured by LED and Argon Laser curing lights. Materials and Methods: DC was measured using FTIR spectroscopy. For measuring temperature rise, composite resin samples were placed in Teflon molds and cured from the top. The thermocouple under samples recorded the temperature rise. After initial radiation and specimens reaching the ambient temperature, reirradiation was done and temperature was recorded again. Both temperature rise and DC data submitted to one-way ANOVA and Tukey-HSD tests (5% significance). Results: The obtained results revealed that DC was not significantly different between the understudy composite resins or curing units. Low shrinkage composite resin showed a significantly higher temperature rise than hybrid composite resin. Argon laser caused the lowest temperature rise among the curing units. Conclusion: Energy density of light curing units was correlated with the DC. Type of composite resin and light curing unit had a significant effect on temperature rise due to polymerization and curing unit, respectively. PMID:27843507

Effect of LED and Argon Laser on Degree of Conversion and Temperature Rise of Hybrid and Low Shrinkage Composite Resins.

PubMed

Pahlevan, Ayob; Tabatabaei, Masumeh Hasani; Arami, Sakineh; Valizadeh, Sara

2016-01-01

Different light curing units are used for polymerization of composite resins. The aim of this study was to evaluate the degree of conversion (DC) and temperature rise in hybrid and low shrinkage composite resins cured by LED and Argon Laser curing lights. DC was measured using FTIR spectroscopy. For measuring temperature rise, composite resin samples were placed in Teflon molds and cured from the top. The thermocouple under samples recorded the temperature rise. After initial radiation and specimens reaching the ambient temperature, reirradiation was done and temperature was recorded again. Both temperature rise and DC data submitted to one-way ANOVA and Tukey-HSD tests (5% significance). The obtained results revealed that DC was not significantly different between the understudy composite resins or curing units. Low shrinkage composite resin showed a significantly higher temperature rise than hybrid composite resin. Argon laser caused the lowest temperature rise among the curing units. Energy density of light curing units was correlated with the DC. Type of composite resin and light curing unit had a significant effect on temperature rise due to polymerization and curing unit, respectively.

Marital and Family Characteristics of Workers, March 1974.

ERIC Educational Resources Information Center

Bureau of Labor Statistics (DOL), Washington, DC.

The Special Labor Force Report shows a substantial rise in the labor force participation rates of married women and single and divorced persons. Also explored is the downward trend of married men (55 years old or over) as members of the labor force. This decline was due mainly to early retirements and to some extent to a rising incidence of…

An ecological model of the habitat mosaic in estuarine nursery areas: Part II – Projecting effects of sea level rise on fish production

EPA Science Inventory

Understanding the response of fish populations to habitat change mediated by sea level rise (SLR) is a key component of ecosystem-based management. Yet, no direct link has been established between habitat change due to SLR and fish population production. Here we take a coupled ...

Why Do Higher-Education Costs Rise More Rapidly than Prices in General?

ERIC Educational Resources Information Center

Archibald, Robert B.; Feldman, David H.

2008-01-01

Why do costs in higher education rise more rapidly than prices in general? They do so due to four factors: (1) higher education is a personal-service industry; (2) higher education relies on highly educated labor; (3) because of increased capital usage (in the form of the new technologies), higher education's reliance on highly educated labor has…

A simplified approach for simulating changes in beach habitat due to the combined effectgs of long-term sea level rise, storm erosion, and nourishment

USDA-ARS?s Scientific Manuscript database

Better understanding of vulnerability of coastal habitats to sea level rise and major storm events require the use of simulation models. Coastal habitats also undergo frequent nourishment restoration works in order to maintain their viability. Vulnerability models must be able to assess the combined...

A young-onset frontal dementia with dramatic calcifications due to a novel CSF1R mutation.

PubMed

Gore, Ethan; Manley, Andrew; Dees, Daniel; Appleby, Brian S; Lerner, Alan J

2016-06-01

Neuroimaging and genomic analysis greatly aid in the identification of young-onset dementia antemortem. We present the case of a 33-year-old female with a 2-year rapid decline to dementia and immobility marked by personality change, executive deficits including compulsions, attention deficit, apraxia, Parkinsonism, and pyramidal signs. She had unique and dramatic calcifications and confluent white matter changes on imaging and was found to have a novel mutation in the colony stimulating factor 1 receptor gene causing adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Here, we review ALSP and briefly discuss differential diagnoses.

Sea level change: lessons from the geologic record

USGS Publications Warehouse

,

1995-01-01

Rising sea level is potentially one of the most serious impacts of climatic change. Even a small sea level rise would have serious economic consequences because it would cause extensive damage to the world's coastal regions. Sea level can rise in the future because the ocean surface can expand due to warming and because polar ice sheets and mountain glaciers can melt, increasing the ocean's volume of water. Today, ice caps on Antarctica and Greenland contain 91 and 8 percent of the world's ice, respectively. The world's mountain glaciers together contain only about 1 percent. Melting all this ice would raise sea level about 80 meters. Although this extreme scenario is not expected, geologists know that sea level can rise and fall rapidly due to changing volume of ice on continents. For example, during the last ice age, about 18,000 years ago, continental ice sheets contained more than double the modem volume of ice. As ice sheets melted, sea level rose 2 to 3 meters per century, and possibly faster during certain times. During periods in which global climate was very warm, polar ice was reduced and sea level was higher than today.

Future sea level rise constrained by observations and long-term commitment.

PubMed

Mengel, Matthias; Levermann, Anders; Frieler, Katja; Robinson, Alexander; Marzeion, Ben; Winkelmann, Ricarda

2016-03-08

Sea level has been steadily rising over the past century, predominantly due to anthropogenic climate change. The rate of sea level rise will keep increasing with continued global warming, and, even if temperatures are stabilized through the phasing out of greenhouse gas emissions, sea level is still expected to rise for centuries. This will affect coastal areas worldwide, and robust projections are needed to assess mitigation options and guide adaptation measures. Here we combine the equilibrium response of the main sea level rise contributions with their last century's observed contribution to constrain projections of future sea level rise. Our model is calibrated to a set of observations for each contribution, and the observational and climate uncertainties are combined to produce uncertainty ranges for 21st century sea level rise. We project anthropogenic sea level rise of 28-56 cm, 37-77 cm, and 57-131 cm in 2100 for the greenhouse gas concentration scenarios RCP26, RCP45, and RCP85, respectively. Our uncertainty ranges for total sea level rise overlap with the process-based estimates of the Intergovernmental Panel on Climate Change. The "constrained extrapolation" approach generalizes earlier global semiempirical models and may therefore lead to a better understanding of the discrepancies with process-based projections.

Future sea level rise constrained by observations and long-term commitment

PubMed Central

Mengel, Matthias; Levermann, Anders; Frieler, Katja; Robinson, Alexander; Marzeion, Ben; Winkelmann, Ricarda

2016-01-01

Sea level has been steadily rising over the past century, predominantly due to anthropogenic climate change. The rate of sea level rise will keep increasing with continued global warming, and, even if temperatures are stabilized through the phasing out of greenhouse gas emissions, sea level is still expected to rise for centuries. This will affect coastal areas worldwide, and robust projections are needed to assess mitigation options and guide adaptation measures. Here we combine the equilibrium response of the main sea level rise contributions with their last century's observed contribution to constrain projections of future sea level rise. Our model is calibrated to a set of observations for each contribution, and the observational and climate uncertainties are combined to produce uncertainty ranges for 21st century sea level rise. We project anthropogenic sea level rise of 28–56 cm, 37–77 cm, and 57–131 cm in 2100 for the greenhouse gas concentration scenarios RCP26, RCP45, and RCP85, respectively. Our uncertainty ranges for total sea level rise overlap with the process-based estimates of the Intergovernmental Panel on Climate Change. The “constrained extrapolation” approach generalizes earlier global semiempirical models and may therefore lead to a better understanding of the discrepancies with process-based projections. PMID:26903648

The effects of everolimus on tuberous sclerosis-associated lesions can be dramatic but may be impermanent.

PubMed

Miller, Joseph M; Wachsman, Ashley; Haker, Katherine; Majlessipour, Fataneh; Danielpour, Moise; Puliyanda, Dechu

2015-01-01

Tuberous sclerosis complex (TSC) predisposes to the development of benign lesions within multiple organ systems, including the brain, kidneys, heart, lungs, and skin. Disease mortality is due to space-occupying subependymal giant cell astrocytomas and hemorrhage-prone renal angiomyolipomas. The recent use of mTORC1 inhibitors, such as everolimus, has allowed for direct targeting of TSC-associated mass lesions without apparent effect on surrounding tissues. Because of the mechanism of these drugs, there is reason to believe that these effects are not durable and that there may be need for continued long-term maintenance therapy. We present a case of TSC-associated mass lesions that were ill-suited for definitive surgical therapy. The patient was started on everolimus, however due to a complex social situation treatment was discontinued and ultimately resumed many months later. Radiologic studies acquired before and after each period of therapeutic onset/cessation reveal the dramatic but impermanent effects of mTORC1 inhibition. While everolimus provides a non-invasive way to treat TSC-associated lesions, patients may require lifelong therapy. When termination of therapy is considered, the patient should be made aware of the expectation of potentially dramatic increases in lesion size. If consideration is to be given to definitive surgical therapy, it should be pursued while the patient is still on the medication, or at least soon after treatment is halted.

Quantifying and Projecting Relative Sea-Level Rise At The Regional Scale: The Bangladesh Sea-Level Project (BanD-AID)

NASA Astrophysics Data System (ADS)

Shum, C. K.; Kuo, C. Y.; Guo, J.; Shang, K.; Tseng, K. H.; Wan, J.; Calmant, S.; Ballu, V.; Valty, P.; Kusche, J.; Hossain, F.; Khan, Z. H.; Rietbroek, R.; Uebbing, B.

2014-12-01

The potential for accelerated sea-level rise under anthropogenic warming is a significant societal problem, in particular in world's coastal deltaic regions where about half of the world's population resides. Quantifying geophysical sources of sea-level rise with the goal of improved projection at local scales remains a complex and challenging interdisciplinary research problem. These processes include ice-sheet/glacier ablations, steric sea-level, solid Earth uplift or subsidence due to GIA, tectonics, sediment loading or anthropogenic causes, hydrologic imbalance, and human processes including water retention in reservoirs and aquifer extraction. The 2013 IPCC AR5 concluded that the observed and explained geophysical causes of global geocentric sea-level rise, 1993-2010, is closer towards closure. However, the discrepancy reveals that circa 1.3→37.5% of the observed sea-level rise remains unexplained. This relatively large discrepancy is primarily attributable to the wide range of estimates of respective contributions of Greenland and Antarctic ice-sheets and mountain/peripheral glaciers to sea-level rise. Understanding and quantifying the natural and anthropogenic processes governing solid Earth (land, islands and sea-floor) uplift or subsidence at the regional and local scales remain elusive to enable addressing coastal vulnerability due to relative sea-level rise hazards, such as the Bangladesh Delta. This study focuses on addressing coastal vulnerability of Bangladesh, a Belmont Forum/IGFA project, BanD-AID (http://Belmont-SeaLevel.org). Sea-level rise, along with tectonic, sediment load and groundwater extraction induced land uplift/subsidence, have exacerbated Bangladesh's coastal vulnerability, affecting 150 million people in one of the world's most densely populated regions. Here we present preliminary results using space geodetic observations, including satellite radar and laser altimetry, GRACE gravity, tide gauge, hydrographic, and GPS/InSAR observed land subsidence, and via fingerprint sea-level adjustment and reconstructed sea-level approaches, for improved quantification of major contributions to, and the projection of relative sea-level rise at the Bangladesh delta, towards addressing its coastal vulnerability and sustainability.

Dynamics of Liquids in Edges and Corners (DYLCO): IML-2 Experiment for the BDPU

NASA Technical Reports Server (NTRS)

Langbein, D.; Weislogel, M.

1998-01-01

Knowledge of the behavior of fluids possessing free surfaces is important to many fluid systems, particularly in space, where the normally subtle effects of surface wettability play a more dramatic and often surprising role. DYLCO for the IML-2 mission was proposed as a simple experiment to probe the particular behavior of capillary surfaces in containers of irregular cross section. Temperature control was utilized to vary the fluid-solid contact angle, a questionable thermodynamic parameter of the system, small changes in which can dramatically influence the configuration, stability, and flow of a capillary surface. Container shapes, test fluid, and temperature ranges were selected for observing both local changes in interface curvature as well as a global change in fluid orientation due to a critical wetting phenomenon. The experiment hardware performed beyond what was expected and fluid interfaces could be readily digitized post flight to show the dependence of the interface curvature on temperature. For each of the containers tested surfaces were observed which did not satisfy the classic equations for the prediction of interface shape with constant contact angle boundary condition. This is explained by the presence of contact angle hysteresis arising from expansion and contraction of the liquid during the heating and cooling steps of the test procedure. More importantly, surfaces exceeding the critical surface curvature required for critical wetting were measured, yet no wetting was observed. These findings are indeed curious and pose key questions concerning the role of hysteresis for this critical wetting phenomena. The stability of such surfaces was determined numerically and it is shown that stability is enhance (reduced) when a surface is in its 'advancing' ('receding') state, The analysis shows complete instability as the critical wetting condition is reached. The case of ideal dynamic wetting is addressed analytically in detail with results of significant flow characteristics presented in closed form. The solutions indicate a square root of T dependence of the capillary 'rise' rate which is corroborated by drop tower tests. The analysis clearly shows that infinite time is necessary for surfaces to reorient at the critical wetting transition.

Gardening as vector of a humanization of high-rise building

NASA Astrophysics Data System (ADS)

Lekareva, Nina; Zaslavskaya, Anna

2018-03-01

Article is devoted to issue of integration of vertical gardening into structure of high-rise building in the conditions of the constrained town-planning situation. On the basis of the analysis of the existing experience of design and building of "biopositive" high-rise building ecological, town-planning, social and constructive advantages of the organization of gardens on roofs and vertical gardens are considered [1]. As the main mechanism of increase in investment appeal of high-rise building the principle of a humanization due to gardening of high-rise building taking into account requirements of ecology, energy efficiency of buildings and improvement of quality of construction with minimization of expenses and maximizing comfort moves forward. The National Standards of Green construction designed to adapt the international requirements of architecture and construction of the energy efficient, eco-friendly and comfortable building or a complex to local conditions are considered [2,3].

The contribution to future flood risk in the Severn Estuary from extreme sea level rise due to ice sheet mass loss

NASA Astrophysics Data System (ADS)

Quinn, N.; Bates, P. D.; Siddall, M.

2013-12-01

The rate at which sea levels will rise in the coming century is of great interest to decision makers tasked with developing mitigation policies to cope with the risk of coastal inundation. Accurate estimates of future sea levels are vital in the provision of effective policy. Recent reports from UK Climate Impacts Programme (UKCIP) suggest that mean sea levels in the UK may rise by as much as 80 cm by 2100; however, a great deal of uncertainty surrounds model predictions, particularly the contribution from ice sheets responding to climatic warming. For this reason, the application of semi-empirical modelling approaches for sea level rise predictions has increased of late, the results from which suggest that the rate of sea level rise may be greater than previously thought, exceeding 1 m by 2100. Furthermore, studies in the Red Sea indicate that rapid sea level rise beyond 1m per century has occurred in the past. In light of such research, the latest UKCIP assessment has included a H++ scenario for sea level rise in the UK of up to 1.9 m which is defined as improbable but, crucially, physically plausible. The significance of such low-probability sea level rise scenarios upon the estimation of future flood risk is assessed using the Somerset levels (UK) as a case study. A simple asymmetric probability distribution is constructed to include sea level rise scenarios of up to 1.9 m by 2100 which are added to a current 1:200 year event water level to force a two-dimensional hydrodynamic model of coastal inundation. From the resulting ensemble predictions an estimation of risk by 2100 is established. The results indicate that although the likelihood of extreme sea level rise due to rapid ice sheet mass loss is low, the resulting hazard can be large, resulting in a significant (27%) increase to the projected annual risk. Furthermore, current defence construction guidelines for the coming century in the UK are expected to account for 95% of the sea level rise distribution presented in this research, while the larger, low probability scenarios beyond this level are estimated to contribute a residual annual risk of approximately £0.45 million. These findings clearly demonstrate that uncertainty in future sea level rise is a vital component of coastal flood risk, and therefore, needs to be accounted for by decision makers when considering mitigation policies related to coastal flooding.

Causes and Prevention of Structural Materials Failures in Naval Environments.

DTIC Science & Technology

1984-01-01

atomic hydrogen as the first step; (iii) creation of elastic-plastic zones near the crack tip region due to movement of dislocations under applied...sodium tellurate is added to the charging solution. There is a dramatic drop in hydrogen permeation current due to the reduction of the tellurate ...effect of tellurium which has been deposited. Thus it has been shown that the tellurate ion, an electron acceptor, can delay the production of hydrogen

Evolution of multicellularity coincided with increased diversification of cyanobacteria and the Great Oxidation Event.

PubMed

Schirrmeister, Bettina E; de Vos, Jurriaan M; Antonelli, Alexandre; Bagheri, Homayoun C

2013-01-29

Cyanobacteria are among the most diverse prokaryotic phyla, with morphotypes ranging from unicellular to multicellular filamentous forms, including those able to terminally (i.e., irreversibly) differentiate in form and function. It has been suggested that cyanobacteria raised oxygen levels in the atmosphere around 2.45-2.32 billion y ago during the Great Oxidation Event (GOE), hence dramatically changing life on the planet. However, little is known about the temporal evolution of cyanobacterial lineages, and possible interplay between the origin of multicellularity, diversification of cyanobacteria, and the rise of atmospheric oxygen. We estimated divergence times of extant cyanobacterial lineages under Bayesian relaxed clocks for a dataset of 16S rRNA sequences representing the entire known diversity of this phylum. We tested whether the evolution of multicellularity overlaps with the GOE, and whether multicellularity is associated with significant shifts in diversification rates in cyanobacteria. Our results indicate an origin of cyanobacteria before the rise of atmospheric oxygen. The evolution of multicellular forms coincides with the onset of the GOE and an increase in diversification rates. These results suggest that multicellularity could have played a key role in triggering cyanobacterial evolution around the GOE.

Rising Expectations: Access to Biomedical Information

PubMed Central

Lindberg, D. A. B.; Humphreys, B. L.

2008-01-01

Summary Objective To provide an overview of the expansion in public access to electronic biomedical information over the past two decades, with an emphasis on developments to which the U.S. National Library of Medicine contributed. Methods Review of the increasingly broad spectrum of web-accessible genomic data, biomedical literature, consumer health information, clinical trials data, and images. Results The amount of publicly available electronic biomedical information has increased dramatically over the past twenty years. Rising expectations regarding access to biomedical information were stimulated by the spread of the Internet, the World Wide Web, advanced searching and linking techniques. These informatics advances simplified and improved access to electronic information and reduced costs, which enabled inter-organizational collaborations to build and maintain large international information resources and also aided outreach and education efforts The demonstrated benefits of free access to electronic biomedical information encouraged the development of public policies that further increase the amount of information available. Conclusions Continuing rapid growth of publicly accessible electronic biomedical information presents tremendous opportunities and challenges, including the need to ensure uninterrupted access during disasters or emergencies and to manage digital resources so they remain available for future generations. PMID:18587496

Evolution of multicellularity coincided with increased diversification of cyanobacteria and the Great Oxidation Event

PubMed Central

Schirrmeister, Bettina E.; de Vos, Jurriaan M.; Antonelli, Alexandre; Bagheri, Homayoun C.

2013-01-01

Cyanobacteria are among the most diverse prokaryotic phyla, with morphotypes ranging from unicellular to multicellular filamentous forms, including those able to terminally (i.e., irreversibly) differentiate in form and function. It has been suggested that cyanobacteria raised oxygen levels in the atmosphere around 2.45–2.32 billion y ago during the Great Oxidation Event (GOE), hence dramatically changing life on the planet. However, little is known about the temporal evolution of cyanobacterial lineages, and possible interplay between the origin of multicellularity, diversification of cyanobacteria, and the rise of atmospheric oxygen. We estimated divergence times of extant cyanobacterial lineages under Bayesian relaxed clocks for a dataset of 16S rRNA sequences representing the entire known diversity of this phylum. We tested whether the evolution of multicellularity overlaps with the GOE, and whether multicellularity is associated with significant shifts in diversification rates in cyanobacteria. Our results indicate an origin of cyanobacteria before the rise of atmospheric oxygen. The evolution of multicellular forms coincides with the onset of the GOE and an increase in diversification rates. These results suggest that multicellularity could have played a key role in triggering cyanobacterial evolution around the GOE. PMID:23319632

Millennial-scale sustainability of the Chesapeake Bay Native American oyster fishery

PubMed Central

Rick, Torben C.; Reeder-Myers, Leslie A.; Hofman, Courtney A.; Breitburg, Denise; Lockwood, Rowan; Henkes, Gregory; Kellogg, Lisa; Lowery, Darrin; Luckenbach, Mark W.; Mann, Roger; Ogburn, Matthew B.; Southworth, Melissa; Wah, John; Wesson, James; Hines, Anson H.

2016-01-01

Estuaries around the world are in a state of decline following decades or more of overfishing, pollution, and climate change. Oysters (Ostreidae), ecosystem engineers in many estuaries, influence water quality, construct habitat, and provide food for humans and wildlife. In North America’s Chesapeake Bay, once-thriving eastern oyster (Crassostrea virginica) populations have declined dramatically, making their restoration and conservation extremely challenging. Here we present data on oyster size and human harvest from Chesapeake Bay archaeological sites spanning ∼3,500 y of Native American, colonial, and historical occupation. We compare oysters from archaeological sites with Pleistocene oyster reefs that existed before human harvest, modern oyster reefs, and other records of human oyster harvest from around the world. Native American fisheries were focused on nearshore oysters and were likely harvested at a rate that was sustainable over centuries to millennia, despite changing Holocene climatic conditions and sea-level rise. These data document resilience in oyster populations under long-term Native American harvest, sea-level rise, and climate change; provide context for managing modern oyster fisheries in the Chesapeake Bay and elsewhere around the world; and demonstrate an interdisciplinary approach that can be applied broadly to other fisheries. PMID:27217572

Evidence for strong evolution in galaxy environmental quenching efficiency between z = 1.6 and z = 0.9

NASA Astrophysics Data System (ADS)

Nantais, Julie B.; Muzzin, Adam; van der Burg, Remco F. J.; Wilson, Gillian; Lidman, Chris; Foltz, Ryan; DeGroot, Andrew; Noble, Allison; Cooper, Michael C.; Demarco, Ricardo

2017-02-01

We analyse the evolution of environmental quenching efficiency, the fraction of quenched cluster galaxies which would be star forming if they were in the field, as a function of redshift in 14 spectroscopically confirmed galaxy clusters with 0.87 < z < 1.63 from the Spitzer Adaptation of the Red-Sequence Cluster Survey. The clusters are the richest in the survey at each redshift. Passive fractions rise from 42_{-13}^{+10} per cent at z ˜ 1.6 to 80_{-9}^{+12} per cent at z ˜ 1.3 and 88_{-3}^{+4} per cent at z < 1.1, outpacing the change in passive fraction in the field. Environmental quenching efficiency rises dramatically from 16_{-19}^{+15} per cent at z ˜ 1.6 to 62_{-15}^{+21} per cent at z ˜ 1.3 and 73_{-7}^{+8} per cent at z ≲ 1.1. This work is the first to show direct observational evidence for a rapid increase in the strength of environmental quenching in galaxy clusters at z ˜ 1.5, where simulations show cluster-mass haloes undergo non-linear collapse and virialization.

Millennial-scale sustainability of the Chesapeake Bay Native American oyster fishery.

PubMed

Rick, Torben C; Reeder-Myers, Leslie A; Hofman, Courtney A; Breitburg, Denise; Lockwood, Rowan; Henkes, Gregory; Kellogg, Lisa; Lowery, Darrin; Luckenbach, Mark W; Mann, Roger; Ogburn, Matthew B; Southworth, Melissa; Wah, John; Wesson, James; Hines, Anson H

2016-06-07

Estuaries around the world are in a state of decline following decades or more of overfishing, pollution, and climate change. Oysters (Ostreidae), ecosystem engineers in many estuaries, influence water quality, construct habitat, and provide food for humans and wildlife. In North America's Chesapeake Bay, once-thriving eastern oyster (Crassostrea virginica) populations have declined dramatically, making their restoration and conservation extremely challenging. Here we present data on oyster size and human harvest from Chesapeake Bay archaeological sites spanning ∼3,500 y of Native American, colonial, and historical occupation. We compare oysters from archaeological sites with Pleistocene oyster reefs that existed before human harvest, modern oyster reefs, and other records of human oyster harvest from around the world. Native American fisheries were focused on nearshore oysters and were likely harvested at a rate that was sustainable over centuries to millennia, despite changing Holocene climatic conditions and sea-level rise. These data document resilience in oyster populations under long-term Native American harvest, sea-level rise, and climate change; provide context for managing modern oyster fisheries in the Chesapeake Bay and elsewhere around the world; and demonstrate an interdisciplinary approach that can be applied broadly to other fisheries.

The Conception Approach to the Traffic Control in Czech Cities - Examples from Prague

NASA Astrophysics Data System (ADS)

Tichý, Tomáš; Krajčír, Dušan

Modern and economic development of contemporary towns is without question highly dependent upon traffic infrastructure progress. Automobile transport intensity is dramatically rising in large towns and other Czech and European cities. At the same time number of traffic congestions and accidents is increasing, standing times are becoming longer and ecological stress is also escalated. To solve this situation seems to be the most effective solution to design intelligent traffic light intersection control system, variable message signs, preference of public transportation, road line traffic control and next telematics subsystems. This control system and subsystems should improve permeability of traffic road network with a respect for all demands on recent trends of traffic development in towns and regions.

An Increasing Socioeconomic Gap in Childhood Overweight and Obesity in China

PubMed Central

James, Sherman A.; Merli, M. Giovanna; Zheng, Hui

2014-01-01

We used a new conceptual framework that integrates tenets from health economics, social epidemiology, and health behavior to analyze the impact of socioeconomic forces on the temporal changes in the socioeconomic status (SES) gap in childhood overweight and obesity in China. In data from the China Health and Nutrition Survey for 1991 to 2006, we found increased prevalence of childhood overweight and obesity across all SES groups, but a greater increase among higher-SES children, especially after 1997, when income inequality dramatically increased. Our findings suggest that for China, the increasing SES gap in purchasing power for obesogenic goods, associated with rising income inequality, played a prominent role in the country’s increasing SES gap in childhood obesity and overweight. PMID:24228657

The evolution of human mobility based on the public goods game

NASA Astrophysics Data System (ADS)

Yan, Shiqing

2017-07-01

We explore the evolution of human mobility behavior based on public goods game. By using mean field method, the population distribution in different regions is theoretical calculated. Numerical simulation results show that the correlation between the region's degree and its final population is not significant under a larger human migration rate. Human mobility could effectively promote cooperative behavior and the population balance of different regions. Therefore, encouraging individuals to migrate may increase the total benefits of the whole society. Moreover, increasing the cooperation cost could reduce the number of cooperators, and that would happen to the correlation between the region's degree and its final population. The results indicate the total population could not dramatically rise with the region's degree under an unfair society.

In Search of a Germ Theory Equivalent for Chronic Disease

PubMed Central

2012-01-01

The fight against infectious disease advanced dramatically with the consolidation of the germ theory in the 19th century. This focus on a predominant cause of infections (ie, microbial pathogens) ultimately led to medical and public health advances (eg, immunization, pasteurization, antibiotics). However, the resulting declines in infections in the 20th century were matched by a rise in chronic, noncommunicable diseases, for which there is no single underlying etiology. The discovery of a form of low-grade systemic and chronic inflammation (“metaflammation”), linked to inducers (broadly termed “anthropogens”) associated with modern man-made environments and lifestyles, suggests an underlying basis for chronic disease that could provide a 21st-century equivalent of the germ theory. PMID:22575080

Chaotic mixing in three-dimensional microvascular networks fabricated by direct-write assembly.

PubMed

Therriault, Daniel; White, Scott R; Lewis, Jennifer A

2003-04-01

The creation of geometrically complex fluidic devices is a subject of broad fundamental and technological interest. Here, we demonstrate the fabrication of three-dimensional (3D) microvascular networks through direct-write assembly of a fugitive organic ink. This approach yields a pervasive network of smooth cylindrical channels (approximately 10-300 microm) with defined connectivity. Square-spiral towers, isolated within this vascular network, promote fluid mixing through chaotic advection. These vertical towers give rise to dramatic improvements in mixing relative to simple straight (1D) and square-wave (2D) channels while significantly reducing the device planar footprint. We envisage that 3D microvascular networks will provide an enabling platform for a wide array of fluidic-based applications.

Marine shrimp aquaculture and natural resource degradation in Thailand

NASA Astrophysics Data System (ADS)

Flaherty, Mark; Karnjanakesorn, Choomjet

1995-01-01

Rising demand for shrimp in the developed nations has helped to foster a dramatic growth in marine shrimp aquaculture, particularly in South America and South Asia. In Thailand, Marine shrimp aquaculture is now an important earmer of foreign exchange. The growth in Production has been achieved through the expansion of the culture area and the adoption of intensive production methods. The conversion of near-shore areas to shrimp culture, however, is proving to have many consequences that impinge on the environmental integrity of coastal areas. This paper reviews the development of Thailand's marine shrimp culture industry and examines the nature of the environmental impacts that are emerging. It then discusses the implications these have for rural poor and the long-term viability of the culture industry.

Transformations in understanding the health impacts of air pollutants in the 20th century

NASA Astrophysics Data System (ADS)

Brimblecombe, P.

2009-02-01

The transformations of air pollution in the 20th century are well known. The century opened with urban atmospheres polluted by the combustion products of burning coal: smoke and sulfur dioxide. At the millennium these pollutants had almost vanished, replaced by the pollutants, both primary and secondary, a function of fossil-fuelled vehicles. However transitions in terms of health outcomes have been equally dramatic. Fine particulate matter causes notable cardiovascular problems such as increased incidence of stroke and heart attack, although the mechanism remains somewhat unclear. Cancer inducing air pollutants remain a concern, but in addition more recently there has been a rising interest in the presence of neurotoxins and endocrine disrupting substances in the environment.

Family structure and income inequality in families with children, 1976 to 2000.

PubMed

Martin, Molly A

2006-08-01

Using 24 years of data from the March supplements to the Current Population Survey and detailed categories of family structure, including cohabiting unions, I assess the contribution of changes in family structure to the dramatic rise in family income inequality. Between 1976 and 2000, family structure shifts explain 41% of the increase in inequality, but the influence of family structure change is not uniform within this period or across racial-ethnic groups. In general, the estimated role of family structure change is inversely related to the magnitude of the changes in inequality. Furthermore, by including cohabitation, I find lower levels of total inequality and a weaker role for demographic shifts in family structure for trends in income inequality.

Cardiac Arrhythmias in Adults With Congenital Heart Disease: Scope, Specific Problems, and Management.

PubMed

Lindsay, Ian; Moore, Jeremy P

2015-12-01

Progressive advances in the field of congenital heart disease (CHD) have led to a dramatic rise in the number of affected patients surviving well into adulthood. Groundbreaking and innovative achievements in the medical, surgical, and interventional management of these patients have allowed them to lead full adult lives that have included raising families, completing degrees in higher education, and maintaining successful careers. As patients are living longer, arrhythmias have emerged as one of the most significant factors affecting their morbidity, mortality, and quality of life. This article aims to review the current understanding of arrhythmia within the adult congenital heart disease (ACHD) population, emphasizing recent advances and providing recommendations pertaining to the management of these patients.

Coherent Raman Scattering Microscopy in Biology and Medicine.

PubMed

Zhang, Chi; Zhang, Delong; Cheng, Ji-Xin

2015-01-01

Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free visualization and analysis of functional, endogenous biomolecules in living systems. When compared with spontaneous Raman microscopy, a key advantage of CRS microscopy is the dramatic improvement in imaging speed, which gives rise to real-time vibrational imaging of live biological samples. Using molecular vibrational signatures, recently developed hyperspectral CRS microscopy has improved the readout of chemical information available from CRS images. In this article, we review recent achievements in CRS microscopy, focusing on the theory of the CRS signal-to-noise ratio, imaging speed, technical developments, and applications of CRS imaging in bioscience and clinical settings. In addition, we present possible future directions that the use of this technology may take.

Coherent Raman Scattering Microscopy in Biology and Medicine

PubMed Central

Zhang, Chi; Zhang, Delong; Cheng, Ji-Xin

2016-01-01

Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free visualization and analysis of functional, endogenous biomolecules in living systems. When compared with spontaneous Raman microscopy, a key advantage of CRS microscopy is the dramatic improvement in imaging speed, which gives rise to real-time vibrational imaging of live biological samples. Using molecular vibrational signatures, recently developed hyperspectral CRS microscopy has improved the readout of chemical information available from CRS images. In this article, we review recent achievements in CRS microscopy, focusing on the theory of the CRS signal-to-noise ratio, imaging speed, technical developments, and applications of CRS imaging in bioscience and clinical settings. In addition, we present possible future directions that the use of this technology may take. PMID:26514285

Taxation, smuggling and demand for cigarettes in Canada: evidence from time-series data.

PubMed

Galbraith, J W; Kaiserman, M

1997-06-01

This study analyzes Canadian cigarette consumption and taxation between 1980 and 1994, a period in which there have been large price rises and declines, and a dramatic increase in the consumption of contraband tobacco products. We examine elasticities of legal cigarette sales and total sales (including contraband) with respect to the price of legal cigarettes and various other factors. The growth of the contraband market since 1987 appears to have created two classes of cigarette--taxed and untaxed--with responses to changes in the legal price that are respectively higher, and lower, than was previously the case. The sensitivity of total cigarette sales to the taxation instrument is much lower than it would appear from sales of taxed cigarettes alone.

Cannabis, Cannabinoids, and Cerebral Metabolism: Potential Applications in Stroke and Disorders of the Central Nervous System.

PubMed

Latorre, Julius Gene S; Schmidt, Elena B

2015-09-01

No compound has generated more attention in both the scientific and recently in the political arena as much as cannabinoids. These diverse groups of compounds referred collectively as cannabinoids have both been vilified due to its dramatic and potentially harmful psychotropic effects and glorified due to its equally dramatic and potential application in a number of acute and chronic neurological conditions. Previously illegal to possess, cannabis, the plant where natural form of cannabinoids are derived, is now accepted in a growing number of states for medicinal purpose, and some even for recreational use, increasing opportunities for more scientific experimentation. The purpose of this review is to summarize the growing body of literature on cannabinoids and to present an overview of our current state of knowledge of the human endocannabinoid system in the hope of defining the future of cannabinoids and its potential applications in disorders of the central nervous system, focusing on stroke.

Earth Observations taken by the Expedition 16 Crew

NASA Image and Video Library

2008-02-05

ISS016-E-027426 (5 Feb. 2008) --- Cumulonimbus Cloud over Africa is featured in this image photographed by an Expedition 16 crewmember on the International Space Station. Deemed by many meteorologists as one of the most impressive of cloud formations, cumulonimbus (from the Latin for "puffy" and "dark") clouds form due to vigorous convection of warm and moist unstable air. Surface air warmed by the Sun-heated ground surface rises, and if sufficient atmospheric moisture is present, water droplets will condense as the air mass encounters cooler air at higher altitudes. The air mass itself also expands and cools as it rises due to decreasing atmospheric pressure, a process known as adiabatic cooling. This type of convection is common in tropical latitudes year-round and during the summer season at higher latitudes. As water in the rising air mass condenses and changes from a gaseous to a liquid state, it releases energy to its surroundings, further heating the surrounding air and leading to more convection and rising of the cloud mass to higher altitudes. This leads to the characteristic vertical "towers" associated with cumulonimbus clouds, an excellent example of which is visible in this image (right). If enough moisture is present to condense and continue heating the cloud mass through several convective cycles, a tower can rise to altitudes of approximately 10 kilometers at high latitudes to 20 kilometers in the tropics -- before encountering a region of the atmosphere known as the tropopause. The tropopause is characterized by a strong temperature inversion where the atmosphere is dryer and no longer cools with altitude. This halts further vertical motion of the cloud mass, and causes flattening and spreading of the cloud tops into an anvil-shaped cloud as illustrated by this oblique photograph. The view direction is at an angle from the vertical, rather than straight "down" towards the Earth's surface. The image, photographed while the International Space Station was passing over western Africa near the Senegal-Mali border, shows a fully-formed anvil cloud with numerous smaller cumulonimbus towers rising near it. The high energetics of these storm systems typically make them hazardous due to associated heavy precipitation, lightning, high wind speeds and possible tornadoes.

Game-Changing Innovations: How Culture Can Change the Parameters of Its Own Evolution and Induce Abrupt Cultural Shifts.

PubMed

Kolodny, Oren; Creanza, Nicole; Feldman, Marcus W

2016-12-01

One of the most puzzling features of the prehistoric record of hominid stone tools is its apparent punctuation: it consists of abrupt bursts of dramatic change that separate long periods of largely unchanging technology. Within each such period, small punctuated cultural modifications take place. Punctuation on multiple timescales and magnitudes is also found in cultural trajectories from historical times. To explain these sharp cultural bursts, researchers invoke such external factors as sudden environmental change, rapid cognitive or morphological change in the hominids that created the tools, or replacement of one species or population by another. Here we propose a dynamic model of cultural evolution that accommodates empirical observations: without invoking external factors, it gives rise to a pattern of rare, dramatic cultural bursts, interspersed by more frequent, smaller, punctuated cultural modifications. Our model includes interdependent innovation processes that occur at different rates. It also incorporates a realistic aspect of cultural evolution: cultural innovations, such as those that increase food availability or that affect cultural transmission, can change the parameters that affect cultural evolution, thereby altering the population's cultural dynamics and steady state. This steady state can be regarded as a cultural carrying capacity. These parameter-changing cultural innovations occur very rarely, but whenever one occurs, it triggers a dramatic shift towards a new cultural steady state. The smaller and more frequent punctuated cultural changes, on the other hand, are brought about by innovations that spur the invention of further, related, technology, and which occur regardless of whether the population is near its cultural steady state. Our model suggests that common interpretations of cultural shifts as evidence of biological change, for example the appearance of behaviorally modern humans, may be unwarranted.

Game-Changing Innovations: How Culture Can Change the Parameters of Its Own Evolution and Induce Abrupt Cultural Shifts

PubMed Central

2016-01-01

One of the most puzzling features of the prehistoric record of hominid stone tools is its apparent punctuation: it consists of abrupt bursts of dramatic change that separate long periods of largely unchanging technology. Within each such period, small punctuated cultural modifications take place. Punctuation on multiple timescales and magnitudes is also found in cultural trajectories from historical times. To explain these sharp cultural bursts, researchers invoke such external factors as sudden environmental change, rapid cognitive or morphological change in the hominids that created the tools, or replacement of one species or population by another. Here we propose a dynamic model of cultural evolution that accommodates empirical observations: without invoking external factors, it gives rise to a pattern of rare, dramatic cultural bursts, interspersed by more frequent, smaller, punctuated cultural modifications. Our model includes interdependent innovation processes that occur at different rates. It also incorporates a realistic aspect of cultural evolution: cultural innovations, such as those that increase food availability or that affect cultural transmission, can change the parameters that affect cultural evolution, thereby altering the population’s cultural dynamics and steady state. This steady state can be regarded as a cultural carrying capacity. These parameter-changing cultural innovations occur very rarely, but whenever one occurs, it triggers a dramatic shift towards a new cultural steady state. The smaller and more frequent punctuated cultural changes, on the other hand, are brought about by innovations that spur the invention of further, related, technology, and which occur regardless of whether the population is near its cultural steady state. Our model suggests that common interpretations of cultural shifts as evidence of biological change, for example the appearance of behaviorally modern humans, may be unwarranted. PMID:28036346

Patterns and Potential Drivers of Dramatic Changes in Tibetan Lakes, 1972–2010

PubMed Central

Li, Yingkui; Liao, Jingjuan; Guo, Huadong; Liu, Zewen; Shen, Guozhuang

2014-01-01

Most glaciers in the Himalayas and the Tibetan Plateau are retreating, and glacier melt has been emphasized as the dominant driver for recent lake expansions on the Tibetan Plateau. By investigating detailed changes in lake extents and levels across the Tibetan Plateau from Landsat/ICESat data, we found a pattern of dramatic lake changes from 1970 to 2010 (especially after 2000) with a southwest-northeast transition from shrinking, to stable, to rapidly expanding. This pattern is in distinct contrast to the spatial characteristics of glacier retreat, suggesting limited influence of glacier melt on lake dynamics. The plateau-wide pattern of lake change is related to precipitation variation and consistent with the pattern of permafrost degradation induced by rising temperature. More than 79% of lakes we observed on the central-northern plateau (with continuous permafrost) are rapidly expanding, even without glacial contributions, while lakes fed by retreating glaciers in southern regions (with isolated permafrost) are relatively stable or shrinking. Our study shows the limited role of glacier melt and highlights the potentially important contribution of permafrost degradation in predicting future water availability in this region, where understanding these processes is of critical importance to drinking water, agriculture, and hydropower supply of densely populated areas in South and East Asia. PMID:25372787

Are methamphetamine precursor control laws effective tools to fight the methamphetamine epidemic?

PubMed

Nonnemaker, James; Engelen, Mark; Shive, Daniel

2011-05-01

One of the most notable trends in illegal substance use among Americans over the past decade is the dramatic growth and spread of methamphetamine use. In response to the dramatic rise in methamphetamine use and its associated burden, a broad range of legislations has been passed to combat the problem. In this paper, we assess the impact of retail-level laws intended to restrict chemicals used to manufacture methamphetamine (methamphetamine precursor laws) in reducing indicators of domestic production, methamphetamine availability, and the consequences of methamphetamine use. Specifically, we examine trends in these indicators of methamphetamine supply and use over a period spanning the implementation of the federal Methamphetamine Anti-Proliferation Act (MAPA) (October 2000) and a more stringent state-level restriction enacted in California (January 2000). The results are mixed in terms of the effectiveness of legislative efforts to control methamphetamine production and use, depending on the strength of the legislation (California Uniform Controlled Substances Act versus federal MAPA), the specification of the comparison group, and the particular outcome of interest. Some evidence suggests that domestic production was impacted by these legislative efforts, but there is also evidence that prices fell, purities rose, and treatment episodes increased. Copyright © 2010 John Wiley & Sons, Ltd.

Patterns and potential drivers of dramatic changes in Tibetan lakes, 1972-2010.

PubMed

Li, Yingkui; Liao, Jingjuan; Guo, Huadong; Liu, Zewen; Shen, Guozhuang

2014-01-01

Most glaciers in the Himalayas and the Tibetan Plateau are retreating, and glacier melt has been emphasized as the dominant driver for recent lake expansions on the Tibetan Plateau. By investigating detailed changes in lake extents and levels across the Tibetan Plateau from Landsat/ICESat data, we found a pattern of dramatic lake changes from 1970 to 2010 (especially after 2000) with a southwest-northeast transition from shrinking, to stable, to rapidly expanding. This pattern is in distinct contrast to the spatial characteristics of glacier retreat, suggesting limited influence of glacier melt on lake dynamics. The plateau-wide pattern of lake change is related to precipitation variation and consistent with the pattern of permafrost degradation induced by rising temperature. More than 79% of lakes we observed on the central-northern plateau (with continuous permafrost) are rapidly expanding, even without glacial contributions, while lakes fed by retreating glaciers in southern regions (with isolated permafrost) are relatively stable or shrinking. Our study shows the limited role of glacier melt and highlights the potentially important contribution of permafrost degradation in predicting future water availability in this region, where understanding these processes is of critical importance to drinking water, agriculture, and hydropower supply of densely populated areas in South and East Asia.

Tidal Marshes across a Chesapeake Bay Subestuary Are Not Keeping up with Sea-Level Rise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckett, Leah H.; Baldwin, Andrew H.; Kearney, Michael S.

Sea-level rise is a major factor in wetland loss worldwide, and inmuch of Chesapeake Bay (USA) the rate of sea-level rise is higher than the current global rate of 3.2 mmyr -1 due to regional subsidence.Marshes along estuarine salinity gradients differ in vegetation composition, productivity, decomposition pathways, and sediment dynamics, andmay exhibit different responses to sea-level rise. Coastal marshes persist by building vertically at rates at or exceeding regional sea-level rise. In one of the first studies to examine elevation dynamics across an estuarine salinity gradient, we installed 15 surface elevation tables (SET) and accretion marker-horizon plots (MH) in tidalmore » freshwater, oligohaline, and brackish marshes across a Chesapeake Bay subestuary. Over the course of four years, wetlands across the subestuary decreased 1.8 ± 2.7 mmyr -1 in elevation on average, at least 5 mmyr -1 below that needed to keep pace with global sea-level rise. Elevation change rates did not significantly differ among themarshes studied, and ranged from-9.8 ± 6.9 to 4.5 ± 4.3 mmyr -1. Surface accretion of depositedmineral and organic matter was uniformly high across the estuary (~9–15 mmyr -1), indicating that elevation loss was not due to lack of accretionary input. Position in the estuary and associated salinity regime were not related to elevation change or surface matter accretion. In conclusion, previous studies have focused on surface elevation change inmarshes of uniformsalinity (e.g., salt marshes); however, our findings highlight the need for elevation studies inmarshes of all salinity regimes and different geomorphic positions, and warn that brackish, oligohaline, and freshwater tidal wetlands may be at similarly high risk of submergence in some estuaries.« less

Tidal Marshes across a Chesapeake Bay Subestuary Are Not Keeping up with Sea-Level Rise

PubMed Central

Beckett, Leah H.; Baldwin, Andrew H.; Kearney, Michael S.

2016-01-01

Sea-level rise is a major factor in wetland loss worldwide, and in much of Chesapeake Bay (USA) the rate of sea-level rise is higher than the current global rate of 3.2 mm yr-1 due to regional subsidence. Marshes along estuarine salinity gradients differ in vegetation composition, productivity, decomposition pathways, and sediment dynamics, and may exhibit different responses to sea-level rise. Coastal marshes persist by building vertically at rates at or exceeding regional sea-level rise. In one of the first studies to examine elevation dynamics across an estuarine salinity gradient, we installed 15 surface elevation tables (SET) and accretion marker-horizon plots (MH) in tidal freshwater, oligohaline, and brackish marshes across a Chesapeake Bay subestuary. Over the course of four years, wetlands across the subestuary decreased 1.8 ± 2.7 mm yr-1 in elevation on average, at least 5 mm yr-1 below that needed to keep pace with global sea-level rise. Elevation change rates did not significantly differ among the marshes studied, and ranged from -9.8 ± 6.9 to 4.5 ± 4.3 mm yr-1. Surface accretion of deposited mineral and organic matter was uniformly high across the estuary (~9–15 mm yr-1), indicating that elevation loss was not due to lack of accretionary input. Position in the estuary and associated salinity regime were not related to elevation change or surface matter accretion. Previous studies have focused on surface elevation change in marshes of uniform salinity (e.g., salt marshes); however, our findings highlight the need for elevation studies in marshes of all salinity regimes and different geomorphic positions, and warn that brackish, oligohaline, and freshwater tidal wetlands may be at similarly high risk of submergence in some estuaries. PMID:27467784

Tidal Marshes across a Chesapeake Bay Subestuary Are Not Keeping up with Sea-Level Rise

DOE PAGES

Beckett, Leah H.; Baldwin, Andrew H.; Kearney, Michael S.; ...

2016-07-28

Sea-level rise is a major factor in wetland loss worldwide, and inmuch of Chesapeake Bay (USA) the rate of sea-level rise is higher than the current global rate of 3.2 mmyr -1 due to regional subsidence.Marshes along estuarine salinity gradients differ in vegetation composition, productivity, decomposition pathways, and sediment dynamics, andmay exhibit different responses to sea-level rise. Coastal marshes persist by building vertically at rates at or exceeding regional sea-level rise. In one of the first studies to examine elevation dynamics across an estuarine salinity gradient, we installed 15 surface elevation tables (SET) and accretion marker-horizon plots (MH) in tidalmore » freshwater, oligohaline, and brackish marshes across a Chesapeake Bay subestuary. Over the course of four years, wetlands across the subestuary decreased 1.8 ± 2.7 mmyr -1 in elevation on average, at least 5 mmyr -1 below that needed to keep pace with global sea-level rise. Elevation change rates did not significantly differ among themarshes studied, and ranged from-9.8 ± 6.9 to 4.5 ± 4.3 mmyr -1. Surface accretion of depositedmineral and organic matter was uniformly high across the estuary (~9–15 mmyr -1), indicating that elevation loss was not due to lack of accretionary input. Position in the estuary and associated salinity regime were not related to elevation change or surface matter accretion. In conclusion, previous studies have focused on surface elevation change inmarshes of uniformsalinity (e.g., salt marshes); however, our findings highlight the need for elevation studies inmarshes of all salinity regimes and different geomorphic positions, and warn that brackish, oligohaline, and freshwater tidal wetlands may be at similarly high risk of submergence in some estuaries.« less

Assessing Sea Level Rise Impacts on the Surficial Aquifer in the Kennedy Space Center Region

NASA Astrophysics Data System (ADS)

Xiao, H.; Wang, D.; Hagen, S. C.; Medeiros, S. C.; Warnock, A. M.; Hall, C. R.

2014-12-01

Global sea level rise in the past century due to climate change has been seen at an average rate of approximately 1.7-2.2 mm per year, with an increasing rate over the next century. The increasing SLR rate poses a severe threat to the low-lying land surface and the shallow groundwater system in the Kennedy Space Center in Florida, resulting in saltwater intrusion and groundwater induced flooding. A three-dimensional groundwater flow and salinity transport model is implemented to investigate and evaluate the extent of floods due to rising water table as well as saltwater intrusion. The SEAWAT model is chosen to solve the variable-density groundwater flow and salinity transport governing equations and simulate the regional-scale spatial and temporal evolution of groundwater level and chloride concentration. The horizontal resolution of the model is 50 m, and the vertical domain includes both the Surficial Aquifer and the Floridan Aquifer. The numerical model is calibrated based on the observed hydraulic head and chloride concentration. The potential impacts of sea level rise on saltwater intrusion and groundwater induced flooding are assessed under various sea level rise scenarios. Based on the simulation results, the potential landward movement of saltwater and freshwater fringe is projected. The existing water supply wells are examined overlaid with the projected salinity distribution map. The projected Surficial Aquifer water tables are overlaid with data of high resolution land surface elevation, land use and land cover, and infrastructure to assess the potential impacts of sea level rise. This study provides useful tools for decision making on ecosystem management, water supply planning, and facility management.

Water level and strain changes preceding and following the August 4, 1985 Kettleman Hills, California, earthquake

USGS Publications Warehouse

Roeloffs, E.; Quilty, E.

1997-01-01

Two of the four wells monitored near Parkfield, California, during 1985 showed water level rises beginning three days before the M4 6.1 Kettleman Hills earthquake. In one of these wells, the 3.0 cm rise was nearly unique in five years of water level data. However, in the other well, which showed a 3.8 cm rise, many other changes of comparable size have been observed. Both wells that did not display pre-earthquake rises tap partially confined aquifers that cannot sustain pressure changes due to tectonic strain having periods longer than several days. We evaluate the effect of partial aquifer confinement on the ability of these four wells to display water level changes in response to aquifer strain. Although the vertical hydraulic diffusivities cannot be determined uniquely, we can find a value of diffusivity for each site that is consistent with the site's tidal and barometric responses as well as with the rate of partial recovery of the coseismic water level drops. Furthermore, the diffusivity for one well is high enough to explain why the preseismic rise could not have been detected there. For the fourth well, the diffusivity is high enough to have reduced the size of the preseismic signal as much as 50%, although it should still have been detectable. Imperfect confinement cannot explain the persistent water level changes in the two partially confined aquifers, but it does show that they were not due to volume strain. The pre-earthquake water level rises may have been precursors to the Kettleman Hills earthquake. If so, they probably were not caused by accelerating slip over the part of the fault plane that ruptured in that earthquake because they are of opposite sign to the observed coseismic water level drops.

Role of Off-Line-of-Sight Propagation in Geomagnetic EMP Formation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kruger, Hans W.

The author’s synchrotron radiation based 3D geomagnetic EMP code MACSYNC has been used to explore the impact on pulse rise time and air conductivity of EMP propagation paths to the observer that are located off the direct line-of-sight (LOS) between gamma source and observer. This geometry is always present because, for an isotropic source, most the gammas are emitted at an angle with respect to the LOS. Computations for a 1 kt near-surface burst observed from space yield two principal findings: 1. The rise time is generated by the combined actions of a) electron spreading along the LOS due tomore » the Compton electron emission angular distribution folded with electron multiple scattering effects, and b) radiation arrival time spreading due to length differences for different off-LOS propagation paths. The pulse rise time does not depend on the rise time of the conductivity. The conductivity rise time determines the pulse amplitude. 2. One-dimensional legacy EMP codes are inherently incapable of producing the correct pulse shape because they cannot treat the dependence of the conductivity on two dimensions, i.e. the radius from the source and the angle of the propagation path with the LOS. This divergence from one-dimensionality begins at a small fraction of a nanosecond for a sea-level burst. This effect will also be present in high-altitude bursts, however, determination of its onset time and magnitude requires high-altitude computations which have not yet been done.« less

Development of high-rise buildings: digitalization of life cycle management

NASA Astrophysics Data System (ADS)

Gusakova, Elena

2018-03-01

The analysis of the accumulated long-term experience in the construction and operation of high-rise buildings reveals not only the engineering specificity of such projects, but also systemic problems in the field of project management. Most of the project decisions are made by the developer and the investor in the early stages of the life cycle - from the acquisition of the site to the start of operation, so most of the participants in the construction and operation of the high-rise building are far from the strategic life-cycle management of the project. The solution of these tasks due to the informatization of management has largely exhausted its efficiency resource. This is due to the fact that the applied IT-systems automated traditional "inherited" processes and management structures, and, in addition, they were focused on informatization of the activities of the construction company, rather than the construction project. Therefore, in the development of high-rise buildings, the tasks of researching approaches and methods for managing the full life cycle of projects that will improve their competitiveness become topical. For this purpose, the article substantiates the most promising approaches and methods of informational modeling of high-rise construction as a basis for managing the full life cycle of this project. Reengineering of information interaction schemes for project participants is considered; formation of a unified digital environment for the life cycle of the project; the development of systems for integrating data management and project management.

Predicting Change in Eelgrass Distribution Due to Sea Level Rise

EPA Science Inventory

The eelgrass species Zostera marina is the dominant estuarine seagrass on the Pacific Northwest coast of North America and provides important ecosystem services and functions. The loss of eelgrass bed acreage due to environmental pressures is of world-wide concern, yet predicted ...

Folk Musics and Increasing Diversity in American Music Education, 1900-1916.

ERIC Educational Resources Information Center

Volk, Terese M.

1994-01-01

States that, from 1900-1916, U.S. demographic make-up changed dramatically due to the influx of people from southern and eastern Europe. Also asserts that some of the musics of African Americans and Native Americans were introduced into the music curriculum. (CFR)

Effects of calcium magnesium acetate, a road deicer, on the lentic environment in interior Alaska, interim report

DOT National Transportation Integrated Search

1985-03-01

The application of chloride deicing salts to roadways has increased dramatically in recent years due to public demand for safer winter driving conditions. Unfortunately, these salts create adverse effects such as corrosion of vehicles and bridge stru...

Taking lentils out of their comfort zone

USDA-ARS?s Scientific Manuscript database

Lentil is grown in many parts of the world where the photoperiod and temperature prior to flowering differ dramatically. Cultivars from one region struggle to perform well in other regions due to problems related to phenology. This makes breeders reluctant to use un-adapted material in their crosse...

On quantifying active soil carbon using mid-infrared spectroscopy

EPA Science Inventory

Soil organic matter (SOM) is derived from plant or animal residues deposited to soil and is in various stages of decomposition and mineralization. Total SOM is a common measure of soil quality, although due to its heterogeneous composition SOM can vary dramatically in terms of i...

Handedness Patterns in Autism Suggest Subtypes.

ERIC Educational Resources Information Center

Soper, Henry V.; And Others

1986-01-01

Preliminary data from two samples of autistic children and adults and an assessment procedure appropriate for lower-functioning autistic Ss revealed a dramatic shift away from right-handedness in both autistic samples, due to a raised incidence of two phenotypes: manifest left-handedness and ambiguous handedness. (Author/CL)

Formation of fold and thrust belts on Venus due to horizontal shortening of a laterally heterogeneous lithosphere

NASA Technical Reports Server (NTRS)

Zuber, M. T.; Parmentier, E. M.; Neumann, G. A.

1994-01-01

An outstanding question relevant to understanding the tectonics of Venus is the mechanism of formation of fold and thrust belts, such as the mountain belts that surround Lakshmi Planum in western Ishtar Terra. These structures are typically long (hundreds of km) and narrow (many tens of km), and are often located at the margins of relatively high (km-scale) topographic rises. Previous studies have attempted to explain fold and thrust belts in various areas of Venus in the context of viscous and brittle wedge theory. However, while wedge theory can explain the change in elevation from the rise to the adjacent lowland, it fails to account for a fundamental aspect of the deformation, i.e., the topographic high at the edge of the rise. In this study we quantitatively explore the hypothesis that fold and thrust belt morphology on Venus can alternatively be explained by horizontal shortening of a lithosphere that is laterally heterogeneous, due either to a change in thickness of the lithosphere or the crust. Lateral heterogeneities in lithosphere structure may arise in response to thermal thinning or extensive faulting, while variations in crustal thickness may arise due to either spatially variable melting of mantle material or by horizontal shortening of the crust. In a variable thickness lithosphere or crust that is horizontally shortened, deformation will tend to localize in the vicinity of thickness heterogeneity, resulting in a higher component of dynamic topography there as compared to elsewhere in the shortening lithosphere. This mechanism may thus provide a simple explanation for the topographic high at the edge of the rise.

Formation of fold and thrust belts on Venus due to horizontal shortening of a laterally heterogeneous lithosphere

NASA Astrophysics Data System (ADS)

Zuber, M. T.; Parmentier, E. M.; Neumann, G. A.

1994-03-01

An outstanding question relevant to understanding the tectonics of Venus is the mechanism of formation of fold and thrust belts, such as the mountain belts that surround Lakshmi Planum in western Ishtar Terra. These structures are typically long (hundreds of km) and narrow (many tens of km), and are often located at the margins of relatively high (km-scale) topographic rises. Previous studies have attempted to explain fold and thrust belts in various areas of Venus in the context of viscous and brittle wedge theory. However, while wedge theory can explain the change in elevation from the rise to the adjacent lowland, it fails to account for a fundamental aspect of the deformation, i.e., the topographic high at the edge of the rise. In this study we quantitatively explore the hypothesis that fold and thrust belt morphology on Venus can alternatively be explained by horizontal shortening of a lithosphere that is laterally heterogeneous, due either to a change in thickness of the lithosphere or the crust. Lateral heterogeneities in lithosphere structure may arise in response to thermal thinning or extensive faulting, while variations in crustal thickness may arise due to either spatially variable melting of mantle material or by horizontal shortening of the crust. In a variable thickness lithosphere or crust that is horizontally shortened, deformation will tend to localize in the vicinity of thickness heterogeneity, resulting in a higher component of dynamic topography there as compared to elsewhere in the shortening lithosphere. This mechanism may thus provide a simple explanation for the topographic high at the edge of the rise.

An evaluation of rise time characterization and prediction methods

NASA Technical Reports Server (NTRS)

Robinson, Leick D.

1994-01-01

One common method of extrapolating sonic boom waveforms from aircraft to ground is to calculate the nonlinear distortion, and then add a rise time to each shock by a simple empirical rule. One common rule is the '3 over P' rule which calculates the rise time in milliseconds as three divided by the shock amplitude in psf. This rule was compared with the results of ZEPHYRUS, a comprehensive algorithm which calculates sonic boom propagation and extrapolation with the combined effects of nonlinearity, attenuation, dispersion, geometric spreading, and refraction in a stratified atmosphere. It is shown there that the simple empirical rule considerably overestimates the rise time estimate. In addition, the empirical rule does not account for variations in the rise time due to humidity variation or propagation history. It is also demonstrated that the rise time is only an approximate indicator of perceived loudness. Three waveforms with identical characteristics (shock placement, amplitude, and rise time), but with different shock shapes, are shown to give different calculated loudness. This paper is based in part on work performed at the Applied Research Laboratories, the University of Texas at Austin, and supported by NASA Langley.

Implications of sea level rise scenarios on land use /land cover classes of the coastal zones of Cochin, India.

PubMed

Mani Murali, R; Dinesh Kumar, P K

2015-01-15

Physical responses of the coastal zones in the vicinity of Cochin, India due to sea level rise are investigated based on analysis of inundation scenarios. Quantification of potential habitat loss was made by merging the Land use/Land cover (LU/LC) prepared from the satellite imagery with the digital elevation model. Scenarios were generated for two different rates of sea level rise and responses of changes occurred were made to ascertain the vulnerability and loss in extent. LU/LC classes overlaid on 1 m and 2 m elevation showed that it was mostly covered by vegetation areas followed by water and urban zones. For the sea level rise scenarios of 1 m and 2 m, the total inundation zones were estimated to be 169.11 km(2) and 598.83 km(2) respectively using Geographic Information System (GIS). The losses of urban areas were estimated at 43 km(2) and 187 km(2) for the 1 m and 2 m sea level rise respectively which is alarming information for the most densely populated state of India. Quantitative comparison of other LU/LC classes showed significant changes under each of the inundation scenarios. The results obtained conclusively point that sea level rise scenarios will bring profound effects on the land use and land cover classes as well as on coastal landforms in the study region. Coastal inundation would leave ocean front and inland properties vulnerable. Increase in these water levels would alter the coastal drainage gradients. Reduction in these gradients would increase flooding attributable to rainstorms which could promote salt water intrusion into coastal aquifers and force water tables to rise. Changes in the coastal landforms associated with inundation generate concern in the background that the coastal region may continue to remain vulnerable in the coming decades due to population growth and development pressures. Copyright © 2014 Elsevier Ltd. All rights reserved.

Enhanced mobility of non aqueous phase liquid (NAPL) during drying of wet sand

NASA Astrophysics Data System (ADS)

Govindarajan, Dhivakar; Deshpande, Abhijit P.; Raghunathan, Ravikrishna

2018-02-01

Enhanced upward mobility of a non aqueous phase liquid (NAPL) present in wet sand during natural drying, and in the absence of any external pressure gradients, is reported for the first time. This mobility was significantly higher than that expected from capillary rise. Experiments were performed in a glass column with a small layer of NAPL-saturated sand trapped between two layers of water-saturated sand. Drying of the wet sand was induced by flow of air across the top surface of the wet sand. The upward movement of the NAPL, in the direction of water transport, commenced when the drying effect reached the location of the NAPL and continued as long as there was significant water evaporation in the vicinity of NAPL, indicating a clear correlation between the NAPL rise and water evaporation. The magnitude and the rate of NAPL rise was measured at different water evaporation rates, different initial locations of the NAPL, different grain size of the sand and the type of NAPL (on the basis of different NAPL-glass contact angle, viscosity and density). A positive correlation was observed between average rate of NAPL rise and the water evaporation while a negative correlation was obtained between the average NAPL rise rate and the NAPL properties of contact angle, viscosity and density. There was no significant correlation of average NAPL rise rate with variation of sand grain size between 0.1 to 0.5 mm. Based on these observations and on previous studies reported in the literature, two possible mechanisms are hypothesized -a) the effect of the spreading coefficient resulting in the wetting of NAPL on the water films created and b) a moving water film due to evaporation that "drags" the NAPL upwards. The NAPL rise reported in this paper has implications in fate and transport of chemicals in NAPL contaminated porous media such as soils and exposed dredged sediment material, which are subjected to varying water saturation levels due to drying and rewetting.

Gushing metal chain

NASA Astrophysics Data System (ADS)

Belyaev, Alexander; Sukhanov, Alexander; Tsvetkov, Alexander

2016-03-01

This article addresses the problem in which a chain falls from a glass from some height. This phenomenon demonstrates a paradoxical rise of the chain over the glass. To explain this effect, an initial hypothesis and an appropriate theory are proposed for calculating the steady fall parameters of the chain. For this purpose, the modified Cayley's problem of falling chain given its rise due to the centrifugal force of upward inertia is solved. Results show that the lift caused by an increase in linear density at the part of chain where it is being bent (the upper part) is due to the convergence of the chain balls to one another. The experiments confirm the obtained estimates of the lifting chain.

Dramatically enhanced self-assembly of GeSi quantum dots with superior photoluminescence induced by the substrate misorientation

NASA Astrophysics Data System (ADS)

Zhou, Tong; Zhong, Zhenyang

2014-02-01

A dramatically enhanced self-assembly of GeSi quantum dots (QDs) is disclosed on slightly miscut Si (001) substrates, leading to extremely dense QDs and even a growth mode transition. The inherent mechanism is addressed in combination of the thermodynamics and the growth kinetics both affected by steps on the vicinal surface. Moreover, temperature-dependent photoluminescence spectra from dense GeSi QDs on the miscut substrate demonstrate a rather strong peak persistent up to 300 K, which is attributed to the well confinement of excitons in the dense GeSi QDs due to the absence of the wetting layer on the miscut substrate.

Intravenous immunoglobulin therapy leading to dramatic improvement in a patient with systemic juvenile idiopathic arthritis and severe pericarditis resistant to steroid pulse therapy.

PubMed

Aizawa-Yashiro, Tomomi; Oki, Eishin; Tsuruga, Kazushi; Nakahata, Tohru; Ito, Etsuro; Tanaka, Hiroshi

2012-05-01

A 7-year-old Japanese boy with a 4-month history of systemic juvenile idiopathic arthritis (s-JIA) experienced disease flare with spiking fever, exanthema and arthralgia. He then developed progressive dyspnea due to severe pericarditis, and proinflammatory hypercytokinemia was suspected. Methylprednisolone pulse therapy was ineffective and echocardiography showed massive pericardial effusion had persisted. Alternatively, subsequent intravenous immunoglobulin (IVIG) therapy resulted in dramatic resolution of the pericardial effusion, and his general condition significantly improved within a few days. This case report may lend further support the use of IVIG for selected patients with s-JIA and severe pericarditis.

Quantifying and Projecting Relative Sea-Level Rise in The Deltaic Regions

NASA Astrophysics Data System (ADS)

Shum, C. K.; Chung-Yen, K.; Calmant, S.; Yang, T. Y.; Guo, Q.; Jia, Y.; Ballu, V.; Guo, J.; Karptychev, M.; Krien, Y.; Kusche, J.; Tseng, K. H.; Wan, J.; Uebbing, B.

2017-12-01

Half of the world's population lives within 200 km of coastlines. Accelerated sea-level rise, compounded by effects of population growth, severe land subsidence due to fluvial sediment compaction/load, and anthropogenic oil and natural gas and ground water extraction, tectonic motion, and the increasing threat of more intense and more frequent cyclone-driven storm surges, have exacerbated the vulnerability of many of world's deltaic regions, including the Bangladesh and the Mississippi River Deltas. At present, understanding and quantifying the natural and anthropogenic processes governing these solid Earth vertical motion processes remain elusive to enable addressing coastal vulnerability due to current and future projection of relative sea-level rise for deltaic regions at the regional scales. Bangladesh, a low-lying and one of the most densely populated countries in the world located at the Bay of Bengal, is prone to transboundary monsoonal flooding, and is believed to be aggravated by more frequent and intensified cyclones resulting from anthropogenic climate change. The Mississippi River Deltaic region has been severely subsiding due primarily to fluvial sediment compaction and load during the last 10 centuries, oil/gas and groundwater extractions, and commercial developments, making it vulnerable to sea-level rise hazards. Here we present results of global geocentric sea-level rise, 1950-2016, separating vertical land motion at global tide gauge datum, by integrating tide gauge and radar altimeter records in a novel sea-level reconstruction scheme, focusing on the Mississippi River and the Bangladesh Deltas. We then integrate the resulting sea level estimates with historic imageries, GPS and InSAR data, as well as sediment isostatic and load model predicted present-day land subsidence, to constrain the 3D land motion to study the impacts of various scenarios of future relative sea level projections on the Bangladesh Delta to the end of the 21st Century and beyond.

Portrait of a Warming Ocean and Rising Sea Levels: Trend of Sea Level Change 1993-2008

NASA Technical Reports Server (NTRS)

2008-01-01

Warming water and melting land ice have raised global mean sea level 4.5 centimeters (1.7 inches) from 1993 to 2008. But the rise is by no means uniform. This image, created with sea surface height data from the Topex/Poseidon and Jason-1 satellites, shows exactly where sea level has changed during this time and how quickly these changes have occurred.

It's also a road map showing where the ocean currently stores the growing amount of heat it is absorbing from Earth's atmosphere and the heat it receives directly from the Sun. The warmer the water, the higher the sea surface rises. The location of heat in the ocean and its movement around the globe play a pivotal role in Earth's climate.

Light blue indicates areas in which sea level has remained relatively constant since 1993. White, red, and yellow are regions where sea levels have risen the most rapidly up to 10 millimeters per year and which contain the most heat. Green areas have also risen, but more moderately. Purple and dark blue show where sea levels have dropped, due to cooler water.

The dramatic variation in sea surface heights and heat content across the ocean are due to winds, currents and long-term changes in patterns of circulation. From 1993 to 2008, the largest area of rapidly rising sea levels and the greatest concentration of heat has been in the Pacific, which now shows the characteristics of the Pacific Decadal Oscillation (PDO), a feature that can last 10 to 20 years or even longer.

In this 'cool' phase, the PDO appears as a horseshoe-shaped pattern of warm water in the Western Pacific reaching from the far north to the Southern Ocean enclosing a large wedge of cool water with low sea surface heights in the eastern Pacific. This ocean/climate phenomenon may be caused by wind-driven Rossby waves. Thousands of kilometers long, these waves move from east to west on either side of the equator changing the distribution of water mass and heat.

This image of sea level trend also reveals a significant area of rising sea levels in the North Atlantic where sea levels are usually low. This large pool of rapidly rising warm water is evidence of a major change in ocean circulation. It signals a slow down in the sub-polar gyre, a counter-clockwise system of currents that loop between Ireland, Greenland and Newfoundland.

Such a change could have an impact on climate since the sub-polar gyre may be connected in some way to the nearby global thermohaline circulation, commonly known as the global conveyor belt. This is the slow-moving circulation in which water sinks in the North Atlantic at different locations around the sub-polar gyre, spreads south, travels around the globe, and slowly up-wells to the surface before returning around the southern tip of Africa. Then it winds its way through the surface currents in the Atlantic and eventually comes back to the North Atlantic.

It is unclear if the weakening of the North Atlantic sub-polar gyre is part of a natural cycle or related to global warming.

This image was made possible by the detailed record of sea surface height measurements begun by Topex/Poseidon and continued by Jason-1. The recently launched Ocean Surface Topography Mission on the Jason-2 satellite (OSTM/Jason-2) will soon take over this responsibility from Jason-1. The older satellite will move alongside OSTM/Jason-2 and continue to measure sea surface height on an adjacent ground track for as long as it is in good health.

Topex/Poseidon and Jason-1 are joint missions of NASA and the French space agency, CNES. OSTM/Jason-2 is collaboration between NASA; the National Oceanic and Atmospheric Administration; CNES; and the European Organisation for the Exploitation of Meteorological Satellites. JPL manages the U.S. portion of the missions for NASA's Science Mission Directorate, Washington, D.C.

Estimating Temperature Rise Due to Flashlamp Heating Using Irreversible Temperature Indicators

NASA Technical Reports Server (NTRS)

Koshti, Ajay M.

1999-01-01

One of the nondestructive thermography inspection techniques uses photographic flashlamps. The flashlamps provide a short duration (about 0.005 sec) heat pulse. The short burst of energy results in a momentary rise in the surface temperature of the part. The temperature rise may be detrimental to the top layer of the part being exposed. Therefore, it is necessary to ensure the nondestructive nature of the technique. Amount of the temperature rise determines whether the flashlamp heating would be detrimental to the part. A direct method for the temperature measurement is to use of an infrared pyrometer that has much shorter response time than the flash duration. In this paper, an alternative technique is given using the irreversible temperature 'indicators. This is an indirect technique and it measures the temperature rise on the irreversible temperature indicators and computes the incident heat flux. Once the heat flux is known, the temperature rise on the part can be computed. A wedge shaped irreversible temperature indicator for measuring the heat flux is proposed. A procedure is given to use the wedge indicator.

Strategic advantages of high-rise construction

NASA Astrophysics Data System (ADS)

Yaskova, Natalya

2018-03-01

Traditional methods to assess the competitiveness of different types of real estate in the context of huge changes of new technological way of life don't provide building solutions that would be correct from a strategic perspective. There are many challenges due to changes in the consumers' behavior in the housing area. A multiplicity of life models, a variety of opportunities and priorities, traditions and new trends in construction should be assessed in terms of prospective benefits in the environment of the emerging new world order. At the same time, the mane discourse of high-rise construction mainly relates to its design features, technical innovations, and architectural accents. We need to clarify the criteria for economic evaluation of high-rise construction in order to provide decisions with clear and quantifiable contexts. The suggested approach to assessing the strategic advantage of high-rise construction and the prospects for capitalization of high-rise buildings poses new challenges for the economy to identify adequate quantitative assessment methods of the high-rise buildings economic efficiency, taking into account all stages of their life cycle.

Army Corps of Engineers: Efforts to Assess the Impact of Extreme Weather Events

DTIC Science & Technology

2015-07-01

evaluate the effects of projected future sea level change on its projects and what to consider when adapting projects to this projected change. In...vulnerability assessments for sea level rise on its coastal projects and has begun conducting such assessments at inland watersheds. U.S. Army Corps of...Army Corps of Engineers’ Hurricane Barrier Design Elevation Changes Due to Sea Level Rise 30 Contents

Chaotic transport and damping from θ-ruffled separatrices.

PubMed

Kabantsev, A A; Dubin, Daniel H E; Driscoll, C F; Tsidulko, Yu A

2010-11-12

Variations in magnetic or electrostatic confinement fields give rise to trapping separatrices, and neoclassical transport theory analyzes effects from collision-induced separatrix crossings. Experiments on pure electron plasmas now quantitatively characterize a broad range of transport and wave damping effects due to "chaotic" separatrix crossings, which occur due to equilibrium plasma rotation across θ-ruffled separatrices, and due to wave-induced separatrix fluctuations.

High tides and rising seas: potential effects on estuarine waterbirds

USGS Publications Warehouse

Erwin, R.M.; Sanders, G.M.; Prosser, D.J.; Cahoon, D.R.; Greenberg, Russell; Maldonado, Jesus; Droege, Sam; McDonald, M.V.

2006-01-01

Coastal waterbirds are vulnerable to water-level changes especially under predictions of accelerating sea-level rise and increased storm frequency in the next century. Tidal and wind-driven fluctuations in water levels affecting marshes, their invertebrate communities, and their dependent waterbirds are manifested in daily, monthly, seasonal, annual, and supra-annual (e.g., decadal or 18.6-yr) periodicities. Superimposed on these cyclic patterns is a long-term (50?80 yr) increase in relative sea-level rise that varies from about 2?4 + mm/yr along the Atlantic coastline. At five study sites selected on marsh islands from Cape Cod, Massachusetts to coastal Virginia, we monitored marsh elevation changes and flooding, tide variations over time, and waterbird use. We found from longterm marsh core data that marsh elevations at three of five sites may not be sufficient to maintain pace with current sea-level rise. Results of the short-term (3?4 yr) measures using surface elevation tables suggest a more dramatic difference, with marsh elevation change at four of five sites falling below relative sea-level rise. In addition, we have found a significant increase (in three of four cases) in the rate of surface marsh flooding in New Jersey and Virginia over the past 70?80 yr during May?July when waterbirds are nesting on or near the marsh surface. Short-term, immediate effects of flooding will jeopardize annual fecundity of many species of concern to federal and state agencies, most notably American Black Duck (Anas rubripes), Nelson?s Sharp-tailed Sparrow (Ammodramus nelsoni), Saltmarsh Sharp-tailed Sparrow (A. caudacutus), Seaside Sparrow (A. maritima), Coastal Plain Swamp Sparrow (Melospiza georgiana nigrescens), Black Rail (Laterallus jamaicensis), Forster?s Tern (Sterna forsteri), Gull-billed Tern (S. nilotica), Black Skimmer (Rynchops niger), and American Oystercatcher (Haemotopus palliatus). Forster?s Terns are probably most at risk given the large proportion of their breeding range in the mid-Atlantic and their saltmarsh specialization. At a scale of 1?2 decades, vegetation changes (saltmeadow cordgrass [Spartina patens] and salt grass [Distichlis spicata] converting to smooth cordgrass [Spartina alternifl ora]), interior pond expansion and erosion of marshes will reduce nesting habitat for many of these species, but may enhance feeding habitat of migrant shorebirds and/or migrant or wintering waterfowl. At scales of 50?100 yr, reversion of marsh island complexes to open water may enhance populations of open-bay waterfowl, e.g., Bufflehead (Bucephala albeola) and Canvasback (Aythya valisneria), but reduce nesting habitats dramatically for the above named marsh-nesting species, may reduce estuarine productivity by loss of the detrital food web and nursery habitat for fish and invertebrates, and cause redistribution of waterfowl, shorebirds, and other species. Such scenarios are more likely to occur in the mid- and north Atlantic regions since these estuaries are lower in sediment delivery on average than those in the Southeast. A simple hypothetical example from New Jersey is presented where waterbirds are forced to shift from submerged natural marshes to nearby impoundments, resulting in roughly a 10-fold increase in density. Whether prey fauna are sufficiently abundant to support this level of increase remains an open question, but extreme densities in confined habitats would exacerbate competition, increase disease risk, and possibly increase predation.

Glaciers dominate eustatic sea-level rise in the 21st century

USGS Publications Warehouse

Meier, Mark Frederick; Dyurgerov, M.B.; Rick, Ursula K.; Pfeffer, William Tad; Anderson, Suzanne P.; Glazovsky, Andrey F.

2007-01-01

Ice loss to the sea currently accounts for virtually all of the sea-level rise that is not attributable to ocean warming, and about 60% of the ice loss is from glaciers and ice caps rather than from the two ice sheets. The contribution of these smaller glaciers has accelerated over the past decade, in part due to marked thinning and retreat of marine-terminating glaciers associated with a dynamic instability that is generally not considered in mass-balance and climate modeling. This acceleration of glacier melt may cause 0.1 to 0.25 meter of additional sea-level rise by 2100.

Infiltration of MHD liquid into a deformable porous material

NASA Astrophysics Data System (ADS)

Naseem, Anum; Mahmood, Asif; Siddique, J. I.; Zhao, Lifeng

2018-03-01

We analyze the capillary rise dynamics for magnetohydrodynamics (MHD) fluid flow through deformable porous material in the presence of gravity effects. The modeling is performed using mixture theory approach and mathematical manipulation yields a nonlinear free boundary problem. Due to the capillary rise action, the pressure gradient in the liquid generates a stress gradient that results in the deformation of porous substrate. The capillary rise process for MHD fluid slows down as compared to Newtonian fluid case. Numerical solutions are obtained using a method of lines approach. The graphical results are presented for important physical parameters, and comparison is presented with Newtonian fluid case.

State-Of-The-Science Review: Everything NanoSilver and More

EPA Science Inventory

Silver has been known to be a potent antibacterial, antifungal and antiviral agent, but in recent years, the use of silver as a biocide in solution, suspension, and especially in nano-particulate form has experienced a dramatic revival. Due to the properties of silver at the nano...

Vector-borne viruses of pulse crops, with a particular emphasis on North American cropping systems

USDA-ARS?s Scientific Manuscript database

Pulse crop production in the USA has increased dramatically over the past decade, in part due to their nutritional value and ability to form symbiotic associations with rhizobacteria that fix atmospheric nitrogen. There are several insect-transmitted viruses that are prevalent and periodically quite...

Athletics and Students with Disabilities: What Principals Should Know

ERIC Educational Resources Information Center

Losinski, Mickey; Katsiyannis, Antonis; Yell, Mitchell L.

2014-01-01

Public concern over the general health of children in the United States has risen during recent years due to dramatic decreases in physical activity levels and increases in obesity and other health-related issues. This article examines the participation of students with disabilities in extracurricular activities, particularly athletic activities,…

DEVELOPMENT OF AN EPA METHOD FOR PERFLUOROCALKYL COMPOUNDS IN DRINKING WATER

EPA Science Inventory

Perfluoroalkyl compounds (PFCs) have been manufactured for over 50 years and their use has dramatically increased over the years. Due to their unique properties of repelling both water and oil, PFCs have been used in a wide variety of applications. In 2001, identification of or...

Reactive Attachment Disorder: Implications for School Readiness and School Functioning

ERIC Educational Resources Information Center

Schwartz, Eric; Davis, Andrew S.

2006-01-01

School readiness and functioning in children diagnosed with Reactive Attachment Disorder (RAD) are important issues due to the dramatic impact RAD has on multiple areas of development. The negative impact of impaired or disrupted early relationships, characterized by extreme neglect, abuse, parental mental illness, domestic violence, and repeated…

On quantifying active soil carbon using mid-infrared spectroscopy

USDA-ARS?s Scientific Manuscript database

Soil organic matter (SOM) is derived from plant or animal residues deposited on or in soil and is in various stages of decomposition and mineralization. Total SOM is a common measure of soil quality, although due to its heterogeneous composition SOM can vary dramatically in terms of its biochemical...

Assessing transportation infrastructure impacts on rangelands: Test of a standard rangeland assessment protocol

USDA-ARS?s Scientific Manuscript database

Linear disturbances associated with on and off-road vehicle use on rangelands has increased dramatically throughout the world in recent decades. This increase is due to a variety of factors including increased availability of all-terrain vehicles, infrastructure development (oil, gas, renewable ene...

Stratification of soil chemical and microbial properties under no-till management after lime amendment

USDA-ARS?s Scientific Manuscript database

Adoption of no-till (NT) technology in the dryland cropping region of the inland Pacific Northwest (iPNW) has dramatically reduced soil erosion compared to conventional tillage. Soils under continuous NT, however, often produce stratified soil acidification compared with conventional tillage due to ...

Soil carbon in natural, cultivated, and restored depressional wetlands in the Mid-Atlantic Coastal Plain

USDA-ARS?s Scientific Manuscript database

Aerial extent of wetland ecosystems have decreased dramatically since precolonial times due to the conversion of these areas for human use. Wetlands provide various ecosystem services, and conservation efforts are being made to restore wetlands and their functions, including soil carbon storage. Thi...

Autonomous measurements of bridge pier and abutment scour using motion-sensing radio transmitters : technical transfer summary.

DOT National Transportation Integrated Search

2010-01-01

Scour around the foundations (piers and abutments) of a bridge due to river flow is often referred to as bridge scour. Bridge scour is a problem of national scope that has dramatic impacts on economics and safety of the traveling public. Bridge...

Nutritional impacts on gene expression in the surface mucosa of blue catfish (Ictalurus furcatus)

USDA-ARS?s Scientific Manuscript database

Short-term feed deprivation is a common occurrence in both wild and farmed fish species, due to reproductive processes, seasonal variations in temperature, or in response to a disease outbreak. Fasting can have dramatic physiological and biological onsequences for fish, including impacts on mucosal ...

Sea-level rise in New Jersey over the past 5000 years: Implications to anthropogenic changes

USGS Publications Warehouse

Miller, Kenneth G.; Sugarman, Peter J.; Browning, James V.; Horton, Benjamin P.; Stanley, Alissa; Kahn, Alicia; Uptegrove, Jane; Aucott, Michael

2009-01-01

We present a mid to late Holocene sea-level record derived from drilling the New Jersey coast that shows a relatively constant rise of 1.8??mm/yr from ~ 5000 to 500 calibrated calendar years before present (yrBP). This contrasts with previous New Jersey estimates that showed only 0.5??mm/yr rise since 2000??yrBP. Comparison with other Mid-Atlantic sea-level records (Delaware to southern New England) indicates surprising uniformity considering different proximities to the peripheral bulge of the Laurentide ice sheet, with a relative rise throughout the region of ~ 1.7-1.9??mm/yr since ~ 5000??yrBP. This regional sea-level rise includes both: 1) global sea-level (eustatic) rise; and 2) far-field geoidal subsidence (estimated as ~ 0.8-1.4??mm/yr today) due to removal of the Laurentide ice sheet and water loading. Correcting for geoidal subsidence, the U.S. east coast records suggest a global sea-level (eustatic) rise of ~ 0.4-1.0??mm/yr (with a best estimate of 0.7 ?? 0.3??mm/yr) since 5000??yrBP. Comparison with other records provides a best estimate of pre-anthropogenic global sea-level rise of < 1.0??mm/yr from 5000 until ~ 200??yrBP. Tide gauge data indicate a 20th century rate of eustatic rise of 1.8??mm/yr, whereas both tide gauge and satellite data suggest an increase in the rate of rise to ~ 3.3??mm/yr from 1993-2006 AD. This indicates that the modern rise (~ 3.3??mm/yr) is significantly higher than the pre-anthropogenic rise (0.7 ?? 0.3??mm/yr). ?? 2008 Elsevier B.V. All rights reserved.

Metallochaperone for Cu,Zn-superoxide dismutase (CCS) protein but not mRNA is higher in organs from copper-deficient mice and rats.

PubMed

Prohaska, Joseph R; Broderius, Margaret; Brokate, Bruce

2003-09-15

Cu,Zn-superoxide dismutase (SOD1) is an abundant metalloenzyme important in scavenging superoxide ions. Cu-deficient rats and mice have lower SOD1 activity and protein, possibly because apo-SOD1 is degraded faster than holo-SOD1. SOD1 interacts with and requires its metallochaperone CCS for donating copper. We produced dietary Cu deficiency in rodents to determine if the reduction in SOD1 was related to the level of its specific metallochaperone CCS. CCS levels determined by immunoblot were 2- to 3-fold higher in liver, heart, kidney, and brain from male Cu-deficient rats and mice under a variety of conditions. CCS was also higher in livers of Cu-deficient dams. Interestingly, CCS levels in brain of Cu-deficient mice were also higher even though SOD1 activity and protein were not altered, suggesting that the rise in CCS is correlated with altered Cu status rather than a direct result of lower SOD1. A DNA probe specific for rat CCS detected a single transcript by Northern blot hybridization with liver RNA. CCS mRNA levels in mouse and rat liver were not altered by dietary treatment. These results suggest a posttranscriptional mechanism for higher CCS protein when Cu is limiting in the cell, perhaps due to slower protein turnover. Elevation in CCS level is one of the most dramatic alterations in Cu binding proteins accompanying Cu deficiency and may be useful to assess Cu status.

Sex-dependent differences in voluntary physical activity.

PubMed

Rosenfeld, Cheryl S

2017-01-02

Numbers of overweight and obese individuals are increasing in the United States and globally, and, correspondingly, the associated health care costs are rising dramatically. More than one-third of children are currently considered obese with a predisposition to type 2 diabetes, and it is likely that their metabolic conditions will worsen with age. Physical inactivity has also risen to be the leading cause of many chronic, noncommunicable diseases (NCD). Children are more physically inactive now than they were in past decades, which may be due to intrinsic and extrinsic factors. In rodents, the amount of time engaged in spontaneous activity within the home cage is a strong predictor of later adiposity and weight gain. Thus, it is important to understand primary motivators stimulating physical activity (PA). There are normal sex differences in PA levels in rodents and humans. The perinatal environment can induce sex-dependent differences in PA disturbances. This Review considers the current evidence for sex differences in PA in rodents and humans. The rodent studies showing that early exposure to environmental chemicals can shape later adult PA responses are discussed. Next, whether there are different motivators stimulating exercise in male vs. female humans are examined. Finally, the brain regions, genes, and pathways that modulate PA in rodents, and possibly by translation in humans, are described. A better understanding of why each sex remains physically active through the life span could open new avenues for preventing and treating obesity in children and adults. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Efficient retention of mud drives land building on the Mississippi Delta plain

NASA Astrophysics Data System (ADS)

Esposito, Christopher R.; Shen, Zhixiong; Törnqvist, Torbjörn E.; Marshak, Jonathan; White, Christopher

2017-07-01

Many of the world's deltas - home to major population centers - are rapidly degrading due to reduced sediment supply, making these systems less resilient to increasing rates of relative sea-level rise. The Mississippi Delta faces some of the highest rates of wetland loss in the world. As a result, multibillion dollar plans for coastal restoration by means of river diversions are currently nearing implementation. River diversions aim to bring sediment back to the presently sediment-starved delta plain. Within this context, sediment retention efficiency (SRE) is a critical parameter because it dictates the effectiveness of river diversions. Several recent studies have focused on land building along the open coast, showing SREs ranging from 5 to 30 %. Here we measure the SRE of a large relict crevasse splay in an inland, vegetated setting that serves as an appropriate model for river diversions. By comparing the mass fraction of sand in the splay deposit to the estimated sand fraction that entered it during its life cycle, we find that this mud-dominated sediment body has an SRE of ≥ 75 %, i.e., dramatically higher than its counterparts on the open coast. Our results show that transport pathways for mud are critical for delta evolution and that SRE is highly variable across a delta. We conclude that sediment diversions located in settings that are currently still vegetated are likely to be the most effective in mitigating land loss and providing long-term sustainability.

Management of community-acquired pneumonia in older adults

PubMed Central

Simonetti, Antonella F.; Viasus, Diego; Garcia-Vidal, Carolina

2014-01-01

Community-acquired pneumonia (CAP) is an increasing problem among the elderly. Multiple factors related to ageing, such as comorbidities, nutritional status and swallowing dysfunction have been implicated in the increased incidence of CAP in the older population. Moreover, mortality in patients with CAP rises dramatically with increasing age. Streptococcus pneumoniae is still the most common pathogen among the elderly, although CAP may also be caused by drug-resistant microorganisms and aspiration pneumonia. Furthermore, in the elderly CAP has a different clinical presentation, often lacking the typical acute symptoms observed in younger adults, due to the lower local and systemic inflammatory response. Several independent prognostic factors for mortality in the elderly have been identified, including factors related to pneumonia severity, inadequate response to infection, and low functional status. CAP scores and biomarkers have lower prognostic value in the elderly, and so there is a need to find new scales or to set new cut-off points for current scores in this population. Adherence to the current guidelines for CAP has a significant beneficial impact on clinical outcomes in elderly patients. Particular attention should also be paid to nutritional status, fluid administration, functional status, and comorbidity stabilizing therapy in this group of frail patients. This article presents an up-to-date review of the main aspects of CAP in elderly patients, including epidemiology, causative organisms, clinical features, and prognosis, and assesses key points for best practices for the management of the disease. PMID:25165554

Diabetic Macular Edema: Options for Adjunct Therapy.

PubMed

Calvo, Pilar; Abadia, Beatriz; Ferreras, Antonio; Ruiz-Moreno, Oscar; Verdes, Guayente; Pablo, Luis E

2015-09-01

Diabetes mellitus (DM) is a chronic disease that affects 387 million people worldwide. Diabetic retinopathy (DR), a common complication of DM, is the main cause of blindness in the active population. Diabetic macular edema (DME) may occur at any stage of DR, and is characterized by vascular hyperpermeability accompanied by hard exudates within the macula. Medical and surgical therapies have dramatically reduced the progression of DR, and timely intervention can reduce the risk of severe vision loss by more than 90 %. In 2012, intravitreal ranibizumab became the first antivascular endothelial growth factor (anti-VEGF) agent approved for DME and, since then, many reports of the use of ranibizumab for DME have been promising. Randomized, prospective, multicenter clinical trials-most notably, RESOLVE, READ-2, RISE/RIDE, RESTORE, DRCR.net protocol I, and RETAIN-reported improvements in best-corrected visual acuity and decreased central retinal thickness as measured with optical coherence tomography in patients with DME. Similar treatment benefits have also been noted in clinical trials evaluating intravitreal aflibercept and bevacizumab (DAVINCI, VISTA/VIVID, and BOLT) and more recently DRCR.net protocol T. Intravitreal steroids (dexamethasone intravitreal implant and fluocinolone acetonide), particularly in refractory cases, also play a significant role in the management of DME (MEAD/CHAMPLAIN and FAMOUS/FAME studies). In summary, over the last 5 years, blocking VEGF and inflammation has been shown to improve visual outcomes in patients with macular edema due to DM, revolutionizing the treatment of center-involved DME and establishing a new standard of care.

The changing nature of admissions to a spinal cord injury center: violence on the rise.

PubMed

Farmer, J C; Vaccaro, A R; Balderston, R A; Albert, T J; Cotler, J

1998-10-01

The purpose of this study was to analyze changing etiologies for admission to a spinal cord injury center. This study was designed to retrospectively analyze the etiology of admissions to a spinal cord injury center during a 15-year period, specifically gunshot versus nongunshot wound injuries. Gunshot wounds are a well-recognized cause of spinal cord injury. In some centers, up to 52% of admissions are due to this, and these trends are believed to be increasing. All patients with spinal cord injury admitted to our center between 1979 and 1993 were analyzed. Frequencies of specific etiologies were determined and then comparisons were made between gunshot wound and nongunshot wound groups. Factors analyzed included age, male/female ratio, ethnic make-up, marital status, employment status, level of injury, and neurologic status. One thousand eight hundred seventeen patients were included. Overall, gunshot wound spinal cord injuries compromised 16.9% of injuries. A clear trend of increasing numbers of admissions was seen between 1984 and 1993 because of this. Gunshot wounds and nongunshot wounds differed dramatically in terms of age, ethnic make-up, marital status, employment status, and neurologic status. Cost attributed to treating gunshot wound injuries at our center for 1993 was 5.4 million dollars. Gunshot wounds as a cause of spinal cord injury are increasing at an alarming rate. The demographics of the gunshot wounds and nongunshot wound spine cord injuries differ significantly.

Noninvasive label-free monitoring of cosmetics and pharmaceuticals in human skin using nonlinear optical microscopy (Conference Presentation)

NASA Astrophysics Data System (ADS)

Osseiran, Sam; Wang, Hequn; Evans, Conor L.

2017-02-01

Over the past decade, nonlinear optical microscopy has seen a dramatic rise in its use in research settings due to its noninvasiveness, enhanced penetration depth, intrinsic optical sectioning, and the ability to probe chemical compounds with molecular specificity without exogenous contrast agents. Nonlinear optical techniques including two-photon excitation fluorescence (2PEF), fluorescence lifetime imaging microscopy (FLIM), second harmonic generation (SHG), coherent anti-Stokes and stimulated Raman scattering (CARS and SRS, respectively), as well as transient and sum frequency absorption (TA and SFA, respectively), have been widely used to explore the physiology and microanatomy of skin. Recently, these modalities have shed light on dermal processes that could not have otherwise been observed, including the spatiotemporal monitoring of cosmetics and pharmaceuticals. However, a challenge quickly arises when studying such chemicals in a dermatological context: many exogenous compounds have optical signatures that can interfere with the signals that would otherwise be acquired from intact skin. For example, oily solvents exhibit strong signals when probing CH2 vibrations with CARS/SRS; chemical sun filters appear bright in 2PEF microscopy; and darkly colored compounds readily absorb light across a broad spectrum, producing strong TA/SFA signals. Thus, this discussion will first focus on the molecular contrast in skin that can be probed using the aforementioned nonlinear optical techniques. This will be followed by an overview of strategies that take advantage of the exogenous compounds' optical signatures to probe spatiotemporal dynamics while preserving endogenous information from skin.

First-principles studies of the local structure and relaxor behavior of Pb(Mg 1 /3Nb2 /3) O3-PbTiO3 -derived ferroelectric perovskite solid solutions

NASA Astrophysics Data System (ADS)

Tan, Hengxin; Takenaka, Hiroyuki; Xu, Changsong; Duan, Wenhui; Grinberg, Ilya; Rappe, Andrew M.

2018-05-01

We have investigated the effect of transition-metal dopants on the local structure of the prototypical 0.75 Pb (Mg1 /3Nb2 /3) O3-0.25 PbTiO3 relaxor ferroelectric. We find that these dopants give rise to very different local structure and other physical properties. For example, when Mg is partially substituted by Cu or Zn, the displacement of Cu or Zn is much larger than that of Mg and is even comparable to that of Nb. The polarization of these systems is also increased, especially for the Cu-doped solution, due to the large polarizability of Cu and Zn. As a result, the predicted maximum dielectric constant temperatures Tm are increased. On the other hand, the replacement of a Ti atom with a Mo or Tc atom dramatically decreases the displacements of the cations and the polarization, and thus, the Tm values are also substantially decreased. The higher Tm cannot be explained by the conventional argument based on the ionic radii of the cations. Furthermore, we find that Cu, Mo, or Tc doping increases the cation displacement disorder. The effect of the dopants on the temperature dispersion Δ Tm , which is the change in Tm for different frequencies, is also discussed. Our findings lay the foundation for further investigations of unexplored dopants.

Statistical review of US macronutrient consumption data, 1965-2011: Americans have been following dietary guidelines, coincident with the rise in obesity.

PubMed

Cohen, Evan; Cragg, Michael; deFonseka, Jehan; Hite, Adele; Rosenberg, Melanie; Zhou, Bin

2015-05-01

For almost 50 y, the US National Health and Nutrition Examination Survey (NHANES) has measured the caloric consumption, and body heights and weights of Americans. The aim of this study was to determine, based on that data, how macronutrient consumption patterns and the weight and body mass index in the US adult population have evolved since the 1960s. We conducted the first comprehensive analysis of the NHANES data, documenting how macronutrient consumption patterns and the weight and body mass index in the US adult population have evolved since the 1960s. Americans in general have been following the nutrition advice that the American Heart Association and the US Departments of Agriculture and Health and Human Services have been issuing for more than 40 y: Consumption of fats has dropped from 45% to 34% with a corresponding increase in carbohydrate consumption from 39% to 51% of total caloric intake. In addition, from 1971 to 2011, average weight and body mass index have increased dramatically, with the percentage of overweight or obese Americans increasing from 42% in 1971 to 66% in 2011. Since 1971, the shift in macronutrient share from fat to carbohydrate is primarily due to an increase in absolute consumption of carbohydrate as opposed to a change in total fat consumption. General adherence to recommendations to reduce fat consumption has coincided with a substantial increase in obesity. Copyright © 2015 Elsevier Inc. All rights reserved.

Differential Metabolic Rearrangements after Cold Storage Are Correlated with Chilling Injury Resistance of Peach Fruits

PubMed Central

Bustamante, Claudia A.; Monti, Laura L.; Gabilondo, Julieta; Scossa, Federico; Valentini, Gabriel; Budde, Claudio O.; Lara, María V.; Fernie, Alisdair R.; Drincovich, María F.

2016-01-01

Reconfiguration of the metabolome is a key component involved in the acclimation to cold in plants; however, few studies have been devoted to the analysis of the overall metabolite changes after cold storage of fruits prior to consumption. Here, metabolite profiling of six peach varieties with differential susceptibility to develop mealiness, a chilling-injury (CI) symptom, was performed. According to metabolic content at harvest; after cold treatment; and after ripening, either following cold treatment or not; peach fruits clustered in distinct groups, depending on harvest-time, cold treatment, and ripening state. Both common and distinct metabolic responses among the six varieties were found; common changes including dramatic galactinol and raffinose rise; GABA, Asp, and Phe increase; and 2-oxo-glutarate and succinate decrease. Raffinose content after long cold treatment quantitatively correlated to the degree of mealiness resistance of the different peach varieties; and thus, raffinose emerges as a candidate biomarker of this CI disorder. Xylose increase after cold treatment was found only in the susceptible genotypes, indicating a particular cell wall reconfiguration of these varieties while being cold-stored. Overall, results indicate that peach fruit differential metabolic rearrangements due to cold treatment, rather than differential metabolic priming before cold, are better related with CI resistance. The plasticity of peach fruit metabolism renders it possible to induce a diverse metabolite array after cold, which is successful, in some genotypes, to avoid CI. PMID:27746802

The Metabolic Basis of Pollen Thermo-Tolerance: Perspectives for Breeding

PubMed Central

Paupière, Marine J.; van Heusden, Adriaan W.; Bovy, Arnaud G.

2014-01-01

Crop production is highly sensitive to elevated temperatures. A rise of a few degrees above the optimum growing temperature can lead to a dramatic yield loss. A predicted increase of 1–3 degrees in the twenty first century urges breeders to develop thermo-tolerant crops which are tolerant to high temperatures. Breeding for thermo-tolerance is a challenge due to the low heritability of this trait. A better understanding of heat stress tolerance and the development of reliable methods to phenotype thermo-tolerance are key factors for a successful breeding approach. Plant reproduction is the most temperature-sensitive process in the plant life cycle. More precisely, pollen quality is strongly affected by heat stress conditions. High temperature leads to a decrease of pollen viability which is directly correlated with a loss of fruit production. The reduction in pollen viability is associated with changes in the level and composition of several (groups of) metabolites, which play an important role in pollen development, for example by contributing to pollen nutrition or by providing protection to environmental stresses. This review aims to underline the importance of maintaining metabolite homeostasis during pollen development, in order to produce mature and fertile pollen under high temperature. The review will give an overview of the current state of the art on the role of various pollen metabolites in pollen homeostasis and thermo-tolerance. Their possible use as metabolic markers to assist breeding programs for plant thermo-tolerance will be discussed. PMID:25271355

The metabolic basis of pollen thermo-tolerance: perspectives for breeding.

PubMed

Paupière, Marine J; van Heusden, Adriaan W; Bovy, Arnaud G

2014-09-30

Crop production is highly sensitive to elevated temperatures. A rise of a few degrees above the optimum growing temperature can lead to a dramatic yield loss. A predicted increase of 1-3 degrees in the twenty first century urges breeders to develop thermo-tolerant crops which are tolerant to high temperatures. Breeding for thermo-tolerance is a challenge due to the low heritability of this trait. A better understanding of heat stress tolerance and the development of reliable methods to phenotype thermo-tolerance are key factors for a successful breeding approach. Plant reproduction is the most temperature-sensitive process in the plant life cycle. More precisely, pollen quality is strongly affected by heat stress conditions. High temperature leads to a decrease of pollen viability which is directly correlated with a loss of fruit production. The reduction in pollen viability is associated with changes in the level and composition of several (groups of) metabolites, which play an important role in pollen development, for example by contributing to pollen nutrition or by providing protection to environmental stresses. This review aims to underline the importance of maintaining metabolite homeostasis during pollen development, in order to produce mature and fertile pollen under high temperature. The review will give an overview of the current state of the art on the role of various pollen metabolites in pollen homeostasis and thermo-tolerance. Their possible use as metabolic markers to assist breeding programs for plant thermo-tolerance will be discussed.

Exploring spatiotemporal changes of the Yangtze River (Changjiang) nitrogen and phosphorus sources, retention and export to the East China Sea and Yellow Sea.

PubMed

Liu, Xiaochen; Beusen, Arthur H W; Van Beek, Ludovicus P H; Mogollón, José M; Ran, Xiangbin; Bouwman, Alexander F

2018-06-04

Nitrogen (N) and phosphorus (P) flows from land to sea in the Yangtze River basin were simulated for the period 1900-2010, by combining models for hydrology, nutrient input to surface water, and an in-stream retention. This study reveals that the basin-wide nutrient budget, delivery to surface water, and in-stream retention increased during this period. Since 2004, the Three Gorges Reservoir has contributed 5% and 7% of N and P basin-wide retention, respectively. With the dramatic rise in nutrient delivery, even this additional retention was insufficient to prevent an increase of riverine export from 337 Gg N yr -1 and 58 Gg P yr -1 (N:P molar ratio = 13) to 5896 Gg N yr -1 and 381 Gg P yr -1 (N:P molar ratio = 35) to the East China Sea and Yellow Sea (ECSYS). The midstream and upstream subbasins dominate the N and P exports to the ECSYS, respectively, due to various human activities along the river. Our spatially explicit nutrient source allocation can aid in the strategic targeting of nutrient reduction policies. We posit that these should focus on improving the agricultural fertilizer and manure use efficiency in the upstream and midstream and better urban wastewater management in the downstream subbasin. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Peaked signals from dark matter velocity structures in direct detection experiments

NASA Astrophysics Data System (ADS)

Lang, Rafael F.; Weiner, Neal

2010-06-01

In direct dark matter detection experiments, conventional elastic scattering of WIMPs results in exponentially falling recoil spectra. In contrast, theories of WIMPs with excited states can lead to nuclear recoil spectra that peak at finite recoil energies ER. The peaks of such signals are typically fairly broad, with ΔER/Epeak ~ 1. We show that in the presence of dark matter structures with low velocity dispersion, such as streams or clumps, peaks from up-scattering can become extremely narrow with FWHM of a few keV only. This differs dramatically from the conventionally expected WIMP spectrum and would, once detected, open the possibility to measure the dark matter velocity structure with high accuracy. As an intriguing example, we confront the observed cluster of 3 events near 42 keV from the CRESST commissioning run with this scenario. Inelastic dark matter particles with a wide range of parameters are capable of producing such a narrow peak. We calculate the possible signals at other experiments, and find that such particles could also give rise to the signal at DAMA, although not from the same stream. Over some range of parameters, a signal would be visible at xenon experiments. We show that such dark matter peaks are a very clear signal and can be easily disentangled from potential backgrounds, both terrestrial or due to WIMP down-scattering, by an enhanced annual modulation in both the amplitude of the signal and its spectral shape.

Management considerations and environmental benefit analysis for turning food garbage into agricultural resources.

PubMed

Tsai, Wen-Tien

2008-09-01

The management of food garbage is of great importance because of its high energy consumption, potential environmental hazards and public health risks. In Taiwan, through the competent authorities at all levels and the citizens' participation in sorting household wastes, many recycling efforts have recently been implemented to further utilize it as available resources such as swine feeds and organic fertilizer by composting. As a result, a total of approximately 570 thousand metric tons was recycled with a recycling ratio of about 21.2% on a basis of food garbage generation in 2006, rising over 22% from a year earlier. These figures showed that compulsory garbage sorting has indeed dramatically increased the recycling of food garbage. The objective of this paper is to present and discuss some management considerations in turning food garbage into agricultural resources due to the compulsory garbage sorting directive in Taiwan. The description first aims at the current status in food garbage generation and its recycling, and at the regulatory polices which have become effective since 2000. It also centers on the environmental and agricultural measures on upgrading food garbage recycling. Based on the preliminary analysis of environmental benefit by the Revised 1996 Intergovernmental Panel on Climate Change (IPCC) Guidelines for National Greenhouse Gas Inventories, it is obvious that composting food garbage is superior to that by traditional treatments (i.e., incineration and sanitary landfill) from the viewpoint of reducing greenhouse gases (i.e., CO(2) and CH(4)) emissions.

Opportunities for Automated Demand Response in California’s Dairy Processing Industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Homan, Gregory K.; Aghajanzadeh, Arian; McKane, Aimee

During periods of peak electrical demand on the energy grid or when there is a shortage of supply, the stability of the grid may be compromised or the cost of supplying electricity may rise dramatically, respectively. Demand response programs are designed to mitigate the severity of these problems and improve reliability by reducing the demand on the grid during such critical times. In 2010, the Demand Response Research Center convened a group of industry experts to suggest potential industries that would be good demand response program candidates for further review. The dairy industry was suggested due to the perception thatmore » the industry had suitable flexibility and automatic controls in place. The purpose of this report is to provide an initial description of the industry with regard to demand response potential, specifically automated demand response. This report qualitatively describes the potential for participation in demand response and automated demand response by dairy processing facilities in California, as well as barriers to widespread participation. The report first describes the magnitude, timing, location, purpose, and manner of energy use. Typical process equipment and controls are discussed, as well as common impediments to participation in demand response and automated demand response programs. Two case studies of demand response at dairy facilities in California and across the country are reviewed. Finally, recommendations are made for future research that can enhance the understanding of demand response potential in this industry.« less

Firn structure of Larsen C Ice Shelf, Antarctic Peninsula, from in-situ geophysical surveys

NASA Astrophysics Data System (ADS)

Kulessa, B.; Brisbourne, A.; Kuipers Munneke, P.; Bevan, S. L.; Luckman, A. J.; Hubbard, B. P.; Ashmore, D.; Holland, P.; Jansen, D.; King, E. C.; O'Leary, M.; McGrath, D.

2015-12-01

Rising surface temperatures have been causing firn layers on Antarctic Peninsula ice shelves to compact, a process that is strongly implicated in ice shelf disintegration. Firn compaction is expected to warm the ice column and given sufficiently wet and compacted firn layers, to allow meltwater to penetrate into surface crevasses and thus enhance the potential for hydrofracture. On Larsen C Ice Shelf a compacting firn layer has previously been inferred from airborne radar and satellite data, with strongly reduced air contents in Larsen C's north and north-west. The hydrological processes governing firn compaction, and the detailed firn structures they produce, have so far remained uncertain however. Using integrated seismic refraction, MASW (Multi-Channel Analysis of Surface Waves), seismoelectric and ground-penetrating radar (GPR) data, we reveal vertical and horizontal changes in firn structure across Larsen C Ice Shelf. Particular attention is paid to the spatial prevalence of refrozen meltwaters within firn, such as the massive subsurface ice layer discovered recently by the NERC-funded MIDAS project in Cabinet Inlet in Larsen C's extreme northwest. Such ice layers or lenses are particularly dramatic manifestations of increased ice shelf densities and temperatures, and contrast sharply with the relatively uncompacted firn layers present in the ice shelf's southeast. We consider our observations in the context of a one-dimensional firn model for Larsen C Ice Shelf that includes melt percolation and refreezing, and discuss temporal changes in firn layer structures due to surface melt and ponding.

Projecting changes in Everglades soil biogeochemistry for carbon and other key elements, to possible 2060 climate and hydrologic scenarios.

PubMed

Orem, William; Newman, Susan; Osborne, Todd Z; Reddy, K Ramesh

2015-04-01

Based on previously published studies of elemental cycling in Everglades soils, we projected how soil biogeochemistry, specifically carbon, nitrogen, phosphorus, sulfur, and mercury might respond to climate change scenarios projected for 2060 by the South Florida Water Management Model. Water budgets and stage hydrographs from this model with future scenarios of a 10% increased or decreased rainfall, a 1.5 °C rise in temperature and associated increase in evapotranspiration (ET) and a 0.5 m rise in sea level were used to predict resulting effects on soil biogeochemistry. Precipitation is a much stronger driver of soil biogeochemical processes than temperature, because of links among water cover, redox conditions, and organic carbon accumulation in soils. Under the 10% reduced rainfall scenario, large portions of the Everglades will experience dry down, organic soil oxidation, and shifts in soil redox that may dramatically alter biogeochemical processes. Lowering organic soil surface elevation may make portions of the Everglades more vulnerable to sea level rise. The 10% increased rainfall scenario, while potentially increasing phosphorus, sulfur, and mercury loading to the ecosystem, would maintain organic soil integrity and redox conditions conducive to normal wetland biogeochemical element cycling. Effects of increased ET will be similar to those of decreased precipitation. Temperature increases would have the effect of increasing microbial processes driving biogeochemical element cycling, but the effect would be much less than that of precipitation. The combined effects of decreased rainfall and increased ET suggest catastrophic losses in carbon- and organic-associated elements throughout the peat-based Everglades.

Long-term operation of submerged membrane bioreactor (MBR) for the treatment of synthetic wastewater containing styrene as volatile organic compound (VOC): Effect of hydraulic retention time (HRT).

PubMed

Fallah, N; Bonakdarpour, B; Nasernejad, B; Alavi Moghadam, M R

2010-06-15

In this study, the membrane bioreactor (MBR) was utilized to remove styrene from a synthetic wastewater having a chemical oxygen demand (COD) and styrene concentration of 1500 mg/L and 50 mg/L, respectively. At two hydraulic retention times (HRTs) of 24 h and 18 h, the MBR was operated for a period in excess of 100 days. The HRT effects were studied and it was found out that the removal efficiency of COD and styrene for both HRTs was consistently higher than 99%. Unlike conventional activated sludge processes (CASPs), no styrene was detected in the exhaust air, which meant that biodegradation was the major styrene removal mechanism at both HRTs. The transmembrane pressure (TMP) profile during the operation of the MBR showed a fairly low and constant TMP up to day 70, after which, the TMP showed a dramatic rise, as a result of the occurrence of severe membrane fouling. It was thought that an increase in styrene loading rate, when HRT was reduced to 18 h, resulted in the release of extracellular polymeric substance (EPS) from the bacterial cells, which in turn was responsible for the rise in soluble microbial product (SMP) and sludge deflocculation. The severe fouling observed during operation of MBR at HRT of 18 h was attributed to the rise in SMP concentrations and decrease in mean floc size and increase in the proportion of small particles in the activated sludge. Copyright 2010 Elsevier B.V. All rights reserved.

Calculation of change in brain temperatures due to exposure to a mobile phone

NASA Astrophysics Data System (ADS)

Van Leeuwen, G. M. J.; Lagendijk, J. J. W.; Van Leersum, B. J. A. M.; Zwamborn, A. P. M.; Hornsleth, S. N.; Kotte, A. N. T. J.

1999-10-01

In this study we evaluated for a realistic head model the 3D temperature rise induced by a mobile phone. This was done numerically with the consecutive use of an FDTD model to predict the absorbed electromagnetic power distribution, and a thermal model describing bioheat transfer both by conduction and by blood flow. We calculated a maximum rise in brain temperature of 0.11 °C for an antenna with an average emitted power of 0.25 W, the maximum value in common mobile phones, and indefinite exposure. Maximum temperature rise is at the skin. The power distributions were characterized by a maximum averaged SAR over an arbitrarily shaped 10 g volume of approximately 1.6 W kg-1. Although these power distributions are not in compliance with all proposed safety standards, temperature rises are far too small to have lasting effects. We verified our simulations by measuring the skin temperature rise experimentally. Our simulation method can be instrumental in further development of safety standards.

Economic efficiency of high-rise construction in the Moscow program of renovation of housing stock

NASA Astrophysics Data System (ADS)

Misailovov, Andrey

2018-03-01

The article considers a new initiative of the regional authorities of updating the housing stock designated as the renovation of housing. Its main aspects are analyzed, including the nature of program, economic efficiency of its implementation due to high-rise construction and the regulatory and legislative framework, the procedure for implementing the program, and the time frame for its implementation. The role of the program for regions in which high depreciation of the housing stock is combined with a limited number of sites for a new housing construction is disclosed. The high-rise construction in the renovation program is presented as a variant of a successful solution not only of the tasks of renovating the housing stock, but also of filling the regional budget. The social and economic orientation of the high-rise construction and the involvement of residents in the process of making town-planning decisions in the field of high-rise construction at all stages of implementing the program are shown.

A Bayesian network to predict vulnerability to sea-level rise: data report

USGS Publications Warehouse

Gutierrez, Benjamin T.; Plant, Nathaniel G.; Thieler, E. Robert

2011-01-01

During the 21st century, sea-level rise is projected to have a wide range of effects on coastal environments, development, and infrastructure. Consequently, there has been an increased focus on developing modeling or other analytical approaches to evaluate potential impacts to inform coastal management. This report provides the data that were used to develop and evaluate the performance of a Bayesian network designed to predict long-term shoreline change due to sea-level rise. The data include local rates of relative sea-level rise, wave height, tide range, geomorphic classification, coastal slope, and shoreline-change rate compiled as part of the U.S. Geological Survey Coastal Vulnerability Index for the U.S. Atlantic coast. In this project, the Bayesian network is used to define relationships among driving forces, geologic constraints, and coastal responses. Using this information, the Bayesian network is used to make probabilistic predictions of shoreline change in response to different future sea-level-rise scenarios.

Simulation of a Dispersive Tsunami due to the 2016 El Salvador-Nicaragua Outer-Rise Earthquake (M w 6.9)

NASA Astrophysics Data System (ADS)

Tanioka, Yuichiro; Ramirez, Amilcar Geovanny Cabrera; Yamanaka, Yusuke

2018-01-01

The 2016 El Salvador-Nicaragua outer-rise earthquake (M w 6.9) generated a small tsunami observed at the ocean bottom pressure sensor, DART 32411, in the Pacific Ocean off Central America. The dispersive observed tsunami is well simulated using the linear Boussinesq equations. From the dispersive character of tsunami waveform, the fault length and width of the outer-rise event is estimated to be 30 and 15 km, respectively. The estimated seismic moment of 3.16 × 1019 Nm is the same as the estimation in the Global CMT catalog. The dispersive character of the tsunami in the deep ocean caused by the 2016 outer-rise El Salvador-Nicaragua earthquake could constrain the fault size and the slip amount or the seismic moment of the event.

Simulation of a Dispersive Tsunami due to the 2016 El Salvador-Nicaragua Outer-Rise Earthquake ( M w 6.9)

NASA Astrophysics Data System (ADS)

Tanioka, Yuichiro; Ramirez, Amilcar Geovanny Cabrera; Yamanaka, Yusuke

2018-04-01

The 2016 El Salvador-Nicaragua outer-rise earthquake ( M w 6.9) generated a small tsunami observed at the ocean bottom pressure sensor, DART 32411, in the Pacific Ocean off Central America. The dispersive observed tsunami is well simulated using the linear Boussinesq equations. From the dispersive character of tsunami waveform, the fault length and width of the outer-rise event is estimated to be 30 and 15 km, respectively. The estimated seismic moment of 3.16 × 1019 Nm is the same as the estimation in the Global CMT catalog. The dispersive character of the tsunami in the deep ocean caused by the 2016 outer-rise El Salvador-Nicaragua earthquake could constrain the fault size and the slip amount or the seismic moment of the event.

IQ Gains and the Binet Decrements.

ERIC Educational Resources Information Center

Flynn, James R.

1984-01-01

Thorndike's Stanford-Binet data suggest that from 1932 to 1971-72 preschool children enjoyed greater IQ gains than older children, possibly due to the rise of television. Additional analysis indicated that gains were either due to sampling error or totally antedated 1947. Gains of 12 IQ points were found for Americans. (Author/EGS)

45 CFR 31.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... past-due, legally enforceable debts to the Department of the Treasury for collection by tax refund... Offices that administer a program that gives rise to a past-due non-tax debt owed to the United States... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION TAX REFUND OFFSET § 31.1 Purpose...

Predicting change in eelgrass distribution due to sea level rise in three Pacific Northwest estuaries

EPA Science Inventory

The eelgrass species Zostera marina is the dominant estuarine seagrass on the Pacific Northwest coast of North America and provides important ecosystem services and functions. The loss of eelgrass bed acreage due to environmental pressures is of world-wide concern, yet predicted...

Care homes may close due to cost of national living wage.

PubMed

Sprinks, Jennifer

2016-08-01

In April this year, a compulsory national living wage (NLW) for people over the age of 25 was introduced across the UK. The NLW increases minimum hourly pay from £6.70 to £7.20, a figure that is due to rise to £9 by 2020.

Modeled atoll shoreline and run-up changes in response to sea-level rise and varying large wave conditions at Wake and Midway Atolls, Northwestern Hawaiian Islands

NASA Astrophysics Data System (ADS)

Shope, J. B.; Storlazzi, C. D.; Hoeke, R. K.

2016-12-01

Atoll islands are dynamic features that respond to seasonal alterations in wave conditions and sea level. With sea level and wave climates projected to change over the next century, it is unclear how shoreline wave runup and erosion patterns along these low elevation islands will respond, making it difficult for communities to prepare for the future. To investigate this, extreme boreal winter and summer wave conditions under a variety of future sea-level rise (SLR) scenarios were modeled at two atolls, Wake and Midway, using Delft3D. Nearshore wave conditions were used to find the potential longshore sediment flux, and wave-driven shoreline erosion was calculated as the divergence of the longshore drift; runup and the locations where runup exceed the berm elevation were also found. Of the aforementioned parameters, SLR is projected to be the dominant force driving future island morphological change and flooding. Increased sea level reduces depth-limited breaking by the atoll reef, allowing larger waves to reach the shoreline, increasing runup height and driving greater inland flooding along most coastlines. Previously protected shorelines, such as lagoon shorelines or shorelines with comparably wide reef flats, are projected see the greatest relative increases in runup. Increases in inland flooding extent were greatest along seaward shorelines due to increases in runup. Changes in incident wave directions had a smaller effect on runup, and the projected changes to incident wave heights had a negligible effect. SLR also drove the greatest changes to island shoreline morphology. Windward islands are projected to become thinner as seaward and lagoonal shorelines erode, accreting toward more leeward shorelines and shorelines with comparably wider reef flats. Similarly, leeward islands are anticipated to become thinner and longer, accreting towards their longitudinal ends. The shorelines of these islands will likely change dramatically over the next century as SLR and altered wave climates drive new erosional regimes. It is vital to the sustainability of island communities that the relative magnitudes of these effects are addressed when planning for projected future climates.

Impact of global warming and rising CO2 levels on coral reef fishes: what hope for the future?

PubMed

Munday, Philip L; McCormick, Mark I; Nilsson, Göran E

2012-11-15

Average sea-surface temperature and the amount of CO(2) dissolved in the ocean are rising as a result of increasing concentrations of atmospheric CO(2). Many coral reef fishes appear to be living close to their thermal optimum, and for some of them, even relatively moderate increases in temperature (2-4°C) lead to significant reductions in aerobic scope. Reduced aerobic capacity could affect population sustainability because less energy can be devoted to feeding and reproduction. Coral reef fishes seem to have limited capacity to acclimate to elevated temperature as adults, but recent research shows that developmental and transgenerational plasticity occur, which might enable some species to adjust to rising ocean temperatures. Predicted increases in P(CO(2)), and associated ocean acidification, can also influence the aerobic scope of coral reef fishes, although there is considerable interspecific variation, with some species exhibiting a decline and others an increase in aerobic scope at near-future CO(2) levels. As with thermal effects, there are transgenerational changes in response to elevated CO(2) that could mitigate impacts of high CO(2) on the growth and survival of reef fishes. An unexpected discovery is that elevated CO(2) has a dramatic effect on a wide range of behaviours and sensory responses of reef fishes, with consequences for the timing of settlement, habitat selection, predator avoidance and individual fitness. The underlying physiological mechanism appears to be the interference of acid-base regulatory processes with brain neurotransmitter function. Differences in the sensitivity of species and populations to global warming and rising CO(2) have been identified that will lead to changes in fish community structure as the oceans warm and becomes more acidic; however, the prospect for acclimation and adaptation of populations to these threats also needs to be considered. Ultimately, it will be the capacity for species to adjust to environmental change over coming decades that will determine the impact of climate change on marine ecosystems.

Response of surge protection devices to fast rising pulses

NASA Technical Reports Server (NTRS)

Mindel, I. N.

1980-01-01

Two types of lightning protection modules incorporating leadless (pill type) Zener like devices were evaluated with regard to their ability to suppress EMP induced transients. Two series of tests were performed to evaluate the ability of these modules to react to fast rate of rise ( 1Kv/ns) transients, and the attenuation introduced and the ability to limit damped sinusoid pulses which may be induced due to an EMP resulting from a nuclear detonation.

Are you mind-wandering, or is your mind on task? The effect of probe framing on mind-wandering reports.

PubMed

Weinstein, Yana; De Lima, Henry J; van der Zee, Tim

2018-04-01

The last decade has seen a dramatic rise in the number of studies that utilize the probe-caught method of collecting mind-wandering reports. This method involves stopping participants during a task, presenting them with a thought probe, and asking them to choose the appropriate report option to describe their thought-state. In this experiment we manipulated the framing of this probe, and demonstrated a substantial difference in mind-wandering reports as a function of whether the probe was presented in a mind-wandering frame compared with an on-task frame. This framing effect has implications both for interpretations of existing data and for methodological choices made by researchers who use the probe-caught mind-wandering paradigm.

Predicting Chronic Climate-Driven Disturbances and Their Mitigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDowell, Nate G.; Michaletz, Sean T.; Bennett, Katrina E.

Society increasingly demands the stable provision of ecosystem resources to support our population. Resource risks from climate-driven disturbances--including drought, heat, insect outbreaks, and wildfire--are rising as a chronic state of disequilibrium results from increasing temperatures and a greater frequency of extreme events. This confluence of increased demand and risk may soon reach critical thresholds. We explain here why extreme chronic disequilibrium of ecosystem function is likely to increase dramatically across the globe, creating no-analog conditions that challenge adaptation. We also present novel mechanistic theory that combines models for disturbance mortality and metabolic scaling to link size-dependent plant mortality to changesmore » in ecosystem stocks and fluxes. Efforts must anticipate and model chronic ecosystem disequilibrium to properly prepare for resilience planning.« less

A focus on recent cases of suicides among Italian children and adolescents and a review of literature.

PubMed

Ferrara, Pietro; Ianniello, Francesca; Cutrona, Costanza; Quintarelli, Fabio; Vena, Flaminia; Del Volgo, Valentina; Caporale, Olga; Malamisura, Monica; De Angelis, Maria Chiara; Gatto, Antonio; Chiaretti, Antonio; Riccardi, Riccardo

2014-07-15

Suicidal behaviors are among the leading causes of death worldwide. The large spread of suicide suggests that educational programs and literature to parents or guardians should include information about the potential risks and potential consequences of the onset of the idea of suicide in children. We identified 55 cases of suicide among children and young adults <18-year-old occurring in Italy between 1st January, 2011 and 31st December, 2013. The results point to the need to increase our understanding of the dramatic rise in suicidal behaviors during childhood/adolescence and of the causal pathways linking these behaviors to child-adolescent mental disorders. During routine care visits, pediatricians should be skilled to recognize risk factors for adolescent suicide in order to intervene appropriately.

Time varying moments, regime switch, and crisis warning: The birth-death process with changing transition probability

NASA Astrophysics Data System (ADS)

Tang, Yinan; Chen, Ping

2014-06-01

The sub-prime crisis in the U.S. reveals the limitation of diversification strategy based on mean-variance analysis. A regime switch and a turning point can be observed using a high moment representation and time-dependent transition probability. Up-down price movements are induced by interactions among agents, which can be described by the birth-death (BD) process. Financial instability is visible by dramatically increasing 3rd to 5th moments one-quarter before and during the crisis. The sudden rising high moments provide effective warning signals of a regime-switch or a coming crisis. The critical condition of a market breakdown can be identified from nonlinear stochastic dynamics. The master equation approach of population dynamics provides a unified theory of a calm and turbulent market.

Consensus in a Precambrian garden

NASA Astrophysics Data System (ADS)

Maggs, William Ward

At the Precambrian-Cambrian boundary, the course of life on Earth underwent a dramatic change that culminated in the rise of predators and other complex animals, a group of paleontologists agreed at a conferece last week.Just prior to 590 million years ago, the ecology of life in the oceans was very simple; soft-shelled multicellular animals called Ediacara lived in apparent harmony with vast mats o f bacteria and algae that covered the seafloor, dependent on the photosynthesis or chemosynthesis of their one-celled hosts for their existence. According to the consensus reached by the scientists, this symbiotic and apparently global “Garden of Ediacara” fell early in the Cambrian Period, as the mats declined and food chains multiplied with new animals that, for the first time in Earth's history, preyed on other living things.