Science.gov

Sample records for rodriguez moonis ali

  1. Flextensional "moonie and Cymbal" Actuators.

    NASA Astrophysics Data System (ADS)

    Dogan, Aydin

    The moonie transducer consists of a piezoelectric or electrostrictive ceramic disc (either in single layer or multilayer form) sandwiched between two metal endcaps, each having a crescent shaped cavity on its inner surface. These metal endcaps serve as a mechanical transformer for converting and amplifying the lateral displacement of the ceramic into an axial motion of the endcaps. Both the d _{33} and d_{31 } piezoelectric coefficients contribute to the axial displacement of the composite. The moonie transducer can be used as hydrophone, transceiver, or actuator. The aim of the present work was to investigate the actuator characteristics of the moonie transducer. Important actuator properties including displacement, generative force, and response time were used to characterize the moonie actuator. An intensive investigation of the cavity size of the endcaps was carried out to understand their effect on the actuator characteristics of the moonie. Displacement increases exponentially with increasing cavity diameter and increases linearly with increasing cavity depth. Displacement is inversely proportional to the endcap thickness. Displacement and generative force show a position dependent behavior. The fastest response time of the moonie actuator varies between 5-50 musec depending on the cavity size. As a part of this thesis a new endcap was developed. The new flextensional actuator was called the "Cymbal". The cavity of the cymbal endcap has a truncated conical shape. A punch and die were designed to fabricate identical endcaps with minimal cost. Cymbal actuators show higher displacement values approximately 40 mum, for the dimensions evaluated in this study, with less position -dependent behavior. They also have higher generative forces (15 N) due to the enlarged active surface, and reduced metal content. The reliability of the moonie actuator depends on the mechanical, electrical and chemical stability of the bonding layer. The characteristics of the bonding

  2. Rodriguez: The State Courts Respond.

    ERIC Educational Resources Information Center

    Long, David C.

    1983-01-01

    Summarizes 16 state court decisions in 15 states concerning equity in statewide school finance systems, in the aftermath of the Supreme Court's San Antonio Independent School District v. Rodriguez" decision. Finds that some state legislatures and courts reformed their finance systems, while others let inequalities continue. (RW)

  3. Rodriguez: The State Courts Respond.

    ERIC Educational Resources Information Center

    Long, David C.

    1983-01-01

    Summarizes 16 state court decisions in 15 states concerning equity in statewide school finance systems, in the aftermath of the Supreme Court's San Antonio Independent School District v. Rodriguez" decision. Finds that some state legislatures and courts reformed their finance systems, while others let inequalities continue. (RW)

  4. [Rafael Rodriguez: artist and activist].

    PubMed

    Molina, C N

    1995-01-01

    Rafael Rodriguez is an artist, activist, and Puerto Rican humanist. As an artist, he has explored various media, including drawing, painting, collage, recycled art and sculpture. He won first prize at the Woodstock Art-Rock Fair in 1969, and had exhibitions at the 1964-65 World's Fair in New York. He uses his art to expose fights for social injustice on a political level. In 1987, Rafael was diagnosed as HIV-positive. After a period of depression, he found in education the strength to rise above his fears and take control of his life. He now lives and works in New Jersey at a facility for persons living with AIDS. He became founder of the Red Ribbon Fellowship, and works with countless other organizations. He has recently returned to his art, which was on hold, as a means of conveying to the community his ideas and preoccupations. In 1987 he created five works which comprise his series called Anguish. They express life and death, the sacred and the profane, and the substance and the emptiness. Rafael uses various elements and diverse religious beliefs in a visual and plastic global vision of humanity and the individual.

  5. School Finance Litigation in a Post-Rodriguez Era

    ERIC Educational Resources Information Center

    Browning, R. Stephen

    1974-01-01

    Summarizes the pertinent rulings of the U.S. Supreme Court in Rodriguez, examines the impact of Rodriguez on future education reform litigation in Federal courts, discusses the potential impact that Rodriguez will have on law suits challenging tax related education inequalities, and examines the impact of the Rodriguez decision on State court…

  6. School Finance a Decade after Rodriguez.

    ERIC Educational Resources Information Center

    Flygare, Thomas J.

    1983-01-01

    Discusses the U.S. Supreme Court's decision in "San Antonio Independent School District v. Rodriguez," handed down 10 years ago, concerning financial equity in the Texas school finance program. Summarizes Justice Powell's majority opinion and Justice Marshall's dissent and introduces the two following articles assessing the decision's…

  7. School Finance a Decade after Rodriguez.

    ERIC Educational Resources Information Center

    Flygare, Thomas J.

    1983-01-01

    Discusses the U.S. Supreme Court's decision in "San Antonio Independent School District v. Rodriguez," handed down 10 years ago, concerning financial equity in the Texas school finance program. Summarizes Justice Powell's majority opinion and Justice Marshall's dissent and introduces the two following articles assessing the decision's…

  8. ALIS deployment in Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Takahashi, Kazunori

    2012-06-01

    Dual sensor is one of the most promising sensors for humanitarian demining operations. Conventional landmine detection depends on highly trained and focused human operators manually sweeping 1m2 plots with a metal detector and listening for characteristic audio signals indicating the presence of AP (Anti-personnel) landmines. In order to reduce the time of plodding detected objects, metal detectors need to be combined with a complimentary subsurface imaging sensor. i.e., GPR(Ground Penetrating Radar). The demining application requires real-time imaging results with centimetre resolution in a highly portable package. We are currently testing a dual sensor ALIS which is a real-time sensor tracking system based on a CCD camera and image processing. In this paper we introduce ALIS systems which we have developed for detection of buried antipersonnel mines and small size explosives. The performance of ALIS has been tested in Cambodia since 2009. More than 80 anti-personnel mines have been detected and removed from local agricultural area. ALIS has cleared more than 70,000 m2 area and returned it to local farmers.

  9. The Face of Women's Health: Helen Rodriguez-Trias

    PubMed Central

    Wilcox, Joyce

    2002-01-01

    The American Public Health Association has announced that it will establish an award in the name of Helen Rodriguez-Trias, MD, its first Latina president, who died of lung cancer on December 27, 2002. Rodriguez-Trias, a nationally known advocate for underserved communities, was awarded the Presidential Citizens Medal by President Clinton in January 2001 for her work on behalf of children, women, people with AIDS, and the poor. This article is based on a dialogue with Rodriguez-Trias that began in September 2001 and ended December 12, 2001. PMID:11919054

  10. ALIS evaluation tests in Croatia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Fujiwara, Jun; Kido, Takashi; Takahashi, Kazunori

    2009-05-01

    Tohoku University, Japan is developing a new hand-held land mine detection dual-sensor (ALIS) which is equipped with a metal detector and a GPR. ALIS is equipped with a sensor tracking system, which can record the GPR and Metal detector signal with its location. The Migration processing drastically increases the quality of the imaging of the buried objects.Evaluation test of ALIS has been conducted several test sites. Tests in real mine fields in Croatia has been conducted between December 2007 and April 2008. Under different soil and environment conditions, ALIS worked well. Then ALIS evaluation test started in Cambodia in February 2009 and we could find discrimination capability of ALIS in test lanes, and we are planning to start evaluation test in real mine fields in Cambodia.

  11. Descubriendo La Lectura: An Interview with Yvonne Rodriguez.

    ERIC Educational Resources Information Center

    Rodriguez, Yvonne; Askew, Billie; Frasier, Dianne

    1997-01-01

    Through an interview with educator Yvonne Rodriguez, this article discusses Descubriendo La Lectura (DLL), the result of educators' efforts in the Collaborative for Reading Recovery in Spanish. It discusses background information about DLL, how it may be implemented, requirements for and means of teacher leader training, and the requirements for…

  12. A Decade after Rodriguez: An Interview with John Coons.

    ERIC Educational Resources Information Center

    Phi Delta Kappan, 1983

    1983-01-01

    John Coons, coauthor of a book on equity in public education finance that influenced the theories tested in "San Antonio Independent School District v. Rodriguez," discusses the issues involved in the case, the likely impact had the decision favored the plaintiffs, and the future of school finance reform. (RW)

  13. Equity in State Education Finance: A Response to "Rodriguez."

    ERIC Educational Resources Information Center

    Verstegen, Deborah A.

    1987-01-01

    A decade after "San Antonio v Rodriguez" (1973), a historic ruling on the unjust Texas educational finance system, the state's Education Opportunity Act (1984) finally replaced existing statutory formulas with a weighted pupil average system and committed $2.8 billion to education over the next three years. A statistical analysis shows…

  14. Chasing Personal Meaning: Pedagogical Lessons through Luis Rodriguez's "Always Running"

    ERIC Educational Resources Information Center

    Theisen-Homer, Victoria

    2014-01-01

    In this autobiographical narrative, the author recounts her experiences teaching the novel "Always Running" by Luis Rodriguez with her English classes at a high school in a gang-heavy area. When she first started teaching, this teacher struggled to engage students. One particularly disruptive student requested to read "Always…

  15. Equity in State Education Finance: A Response to "Rodriguez."

    ERIC Educational Resources Information Center

    Verstegen, Deborah A.

    1987-01-01

    A decade after "San Antonio v Rodriguez" (1973), a historic ruling on the unjust Texas educational finance system, the state's Education Opportunity Act (1984) finally replaced existing statutory formulas with a weighted pupil average system and committed $2.8 billion to education over the next three years. A statistical analysis shows…

  16. A Decade after Rodriguez: An Interview with John Coons.

    ERIC Educational Resources Information Center

    Phi Delta Kappan, 1983

    1983-01-01

    John Coons, coauthor of a book on equity in public education finance that influenced the theories tested in "San Antonio Independent School District v. Rodriguez," discusses the issues involved in the case, the likely impact had the decision favored the plaintiffs, and the future of school finance reform. (RW)

  17. Whose Voice Is It Anyway? Rodriguez' Speech in Retrospect.

    ERIC Educational Resources Information Center

    Villanueva, Victor Jr.

    1987-01-01

    Questions Richard Rodriguez' position that linguistic assimilation for minorities is like alchemy, creating something new and greater than what was. Concludes that it is better for teachers to teach students to use the conventions of standard discourse without accepting the ideology of those for whom the standard dialect is the language of…

  18. Whose Voice Is It Anyway? Rodriguez' Speech in Retrospect.

    ERIC Educational Resources Information Center

    Villanueva, Victor Jr.

    1987-01-01

    Questions Richard Rodriguez' position that linguistic assimilation for minorities is like alchemy, creating something new and greater than what was. Concludes that it is better for teachers to teach students to use the conventions of standard discourse without accepting the ideology of those for whom the standard dialect is the language of…

  19. Chasing Personal Meaning: Pedagogical Lessons through Luis Rodriguez's "Always Running"

    ERIC Educational Resources Information Center

    Theisen-Homer, Victoria

    2014-01-01

    In this autobiographical narrative, the author recounts her experiences teaching the novel "Always Running" by Luis Rodriguez with her English classes at a high school in a gang-heavy area. When she first started teaching, this teacher struggled to engage students. One particularly disruptive student requested to read "Always…

  20. Surfactant Therapy of ALI and ARDS

    PubMed Central

    Raghavendran, K; Willson, D; Notter, RH

    2011-01-01

    This article examines exogenous lung surfactant replacement therapy and its utility in mitigating clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Biophysical research has documented that lung surfactant dysfunction can be reversed or mitigated by increasing surfactant concentration, and multiple studies in animals with ALI/ARDS have shown that respiratory function and pulmonary mechanics in vivo can be improved by exogenous surfactant administration. Exogenous surfactant therapy is a routine intervention in neonatal intensive care, and is life-saving in preventing or treating the neonatal respiratory distress syndrome (NRDS) in premature infants. In applications relevant for lung injury-related respiratory failure and ALI/ARDS, surfactant therapy has been shown to be beneficial in term infants with pneumonia and meconium aspiration lung injury, and in children up to age 21 with direct pulmonary forms of ALI/ARDS. However, extension of exogenous surfactant therapy to adults with respiratory failure and clinical ALI/ARDS remains a challenge. Coverage here reviews clinical studies of surfactant therapy in pediatric and adult patients with ALI/ARDS, particularly focusing on its potential advantages in patients with direct pulmonary forms of these syndromes. Also discussed is the rationale for mechanism-based therapies utilizing exogenous surfactant in combination with agents targeting other aspects of the multifaceted pathophysiology of inflammatory lung injury. Additional factors affecting the efficacy of exogenous surfactant therapy in ALI/ARDS are also described, including the difficulty of effectively delivering surfactants to injured lungs and the existence of activity differences between clinical surfactant drugs. PMID:21742216

  1. Tomographic inversion for ALIS noise and resolution

    NASA Astrophysics Data System (ADS)

    Gustavsson, Björn

    1998-11-01

    In this report the problems of resolution and noise sensitivity of tomographic reconstructions from ground-based multistation imaging of aurora with the auroral large imaging system (ALIS) are considered. ALIS is a ground-based grid of high-performance CCD-imaging stations at high latitudes. For evaluation of the resolution and noise sensitivity of current tomographic reconstruction procedures a full model simulation of the ALIS system is presented. The results show that relative errors are typically in the range 0.05-0.1 for typical noise levels in measurements of aurora. A general method to estimate resolution in a tomographic imaging system is developed and used to give estimates of the horizontal and vertical resolution. Its current limitations and future perspective are briefly discussed. A method to retrieve feasible tomographic reconstructions from a few image projections with variable noise level are outlined.

  2. The Enduring Legacy of "Rodriguez": Creating New Pathways to Equal Educational Opportunity

    ERIC Educational Resources Information Center

    Ogletree, Charles J., Jr., Ed.; Robinson, Kimberly Jenkins, Ed.

    2015-01-01

    In this ambitious volume, leading legal and educational scholars examine "San Antonio Independent School District v. Rodriguez" (1973), the landmark US Supreme Court decision that held that the Constitution does not guarantee equality of educational opportunity. Charles J. Ogletree, Jr., and Kimberly Jenkins Robinson have brought…

  3. Brains versus Brawn: Classed and Racialized Masculinity in Literacy Narratives by Rose, Rodriguez, Villanueva, and Gilyard

    ERIC Educational Resources Information Center

    Launius, Christie

    2009-01-01

    A feminist reading of four prominent literacy narratives--Mike Rose's "Lives on the Boundary," Richard Rodriguez's "Hunger of Memory," Victor Villanueva's "Bootstraps," and Keith Gilyard's "Voices of the Self"--shows that conflicts and anxieties about the consequences of schooling on working-class masculinity animate these texts. Each of these…

  4. The Role of Federal Aid in the Post-Rodriguez Period

    ERIC Educational Resources Information Center

    Burke, Joel S.

    1973-01-01

    Whether the U.S. Supreme Court reverses the Rodriguez v. San Antonio Independent School District (1971)'' decision or upholds it, ordering that state school finance systems not make expenditures a function of local wealth, federal aid can play an important role. (JM)

  5. Forum: Reconsidering the Supreme Court's "Rodriguez" Decision--Is There a Federal Constitutional Right to Education?

    ERIC Educational Resources Information Center

    Ogletree, Charles J., Jr.; Robinson, Kimberly Jenkins; Lindseth, Alfred A.; Testani, Rocco E.; Peifer, Lee A.

    2017-01-01

    Does the U.S. Constitution guarantee a right to education? The Supreme Court declared that it does not in "San Antonio Independent School District v. Rodriguez," a 1973 case alleging that disparities in spending levels among Texas school districts violated students' constitutional rights. This issue's forum contains two essays. The first…

  6. VizieR Online Data Catalog: Very low mass objects in ONC (Rodriguez-Ledesma+, 2010)

    NASA Astrophysics Data System (ADS)

    Rodriguez-Ledesma, M. V.; Mundt, R.; Eisloeffel, J.

    2010-01-01

    Table 1 lists the 638 very low mass objects in the Orion Nebula Cluster with magnitudes between 14-21mag in I band for which NIR (JHK) photometry is available. The I band data is from Rodriguez-Ledesma et al. (2009, Cat. ) and JHK data from 2MASS, UKIDSS, and VLT. (1 data file).

  7. Revisiting "Rodriguez v. Los Angeles Unified School District": A Case of Intra-District Inequities

    ERIC Educational Resources Information Center

    Espinosa, Ruben W.

    2010-01-01

    The educational community and the courts continue to struggle with the challenges of intra-district resource inequality revealed by the California Supreme Court landmark case "Rodriguez v. Los Angeles Unified School District" (1992). Intra-district school resource inequality is one of the remaining bastions of major inequalities in the…

  8. Brains versus Brawn: Classed and Racialized Masculinity in Literacy Narratives by Rose, Rodriguez, Villanueva, and Gilyard

    ERIC Educational Resources Information Center

    Launius, Christie

    2009-01-01

    A feminist reading of four prominent literacy narratives--Mike Rose's "Lives on the Boundary," Richard Rodriguez's "Hunger of Memory," Victor Villanueva's "Bootstraps," and Keith Gilyard's "Voices of the Self"--shows that conflicts and anxieties about the consequences of schooling on working-class masculinity animate these texts. Each of these…

  9. The Role of Federal Aid in the Post-Rodriguez Period

    ERIC Educational Resources Information Center

    Burke, Joel S.

    1973-01-01

    Whether the U.S. Supreme Court reverses the Rodriguez v. San Antonio Independent School District (1971)'' decision or upholds it, ordering that state school finance systems not make expenditures a function of local wealth, federal aid can play an important role. (JM)

  10. The Enduring Legacy of "Rodriguez": Creating New Pathways to Equal Educational Opportunity

    ERIC Educational Resources Information Center

    Ogletree, Charles J., Jr., Ed.; Robinson, Kimberly Jenkins, Ed.

    2015-01-01

    In this ambitious volume, leading legal and educational scholars examine "San Antonio Independent School District v. Rodriguez" (1973), the landmark US Supreme Court decision that held that the Constitution does not guarantee equality of educational opportunity. Charles J. Ogletree, Jr., and Kimberly Jenkins Robinson have brought…

  11. Revisiting "Rodriguez v. Los Angeles Unified School District": A Case of Intra-District Inequities

    ERIC Educational Resources Information Center

    Espinosa, Ruben W.

    2010-01-01

    The educational community and the courts continue to struggle with the challenges of intra-district resource inequality revealed by the California Supreme Court landmark case "Rodriguez v. Los Angeles Unified School District" (1992). Intra-district school resource inequality is one of the remaining bastions of major inequalities in the…

  12. Racial Shame and the Pleasure of Transformation: Richard Rodriguez's Queer Aesthetics of Assimilation

    ERIC Educational Resources Information Center

    Beltran, Cristina

    2012-01-01

    This essay analyzes Latino conservative thought by rethinking the logics of assimilation through a simultaneous exploration of aesthetic possibility and negative affect. Focusing on the writings of Richard Rodriguez, the essay considers how creative forms of self-individuation and political agency cannot easily be decoupled from negative forms of…

  13. VIDEO: Dr. Henry Rodriguez - Proteogenomics in Cancer Medicine | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    Dr. Henry Rodriguez, director of the Office of Cancer Clinical Proteomics Research (OCCPR) at NCI, speaks with ecancer television at WIN 2017 about the translation of the proteins expressed in a patient's tumor into a map for druggable targets. By combining genomic and proteomic information (proteogenomics), leading scientists are gaining new insights into ways to detect and treat cancer due to a more complete and unified understanding of complex biological processes.

  14. Gersch-Rodriguez-Smith computation of deep inelastic electron scattering on 4He

    NASA Astrophysics Data System (ADS)

    Viviani, M.; Kievsky, A.; Rinat, A. S.

    2003-03-01

    We compute cross sections for inclusive scattering of high-energy electrons on 4He, based on the two lowest orders of the Gersch-Rodriguez-Smith series. The required one- and two-particle density matrices are obtained from nonrelativistic 4He wave functions using realistic models for the nucleon-nucleon and three-nucleon interaction. The computed results for E=3.6 GeV agree well with the NE3 SLAC-Virginia data.

  15. Atmospheric monitoring strategy for the Ali site, Tibet

    NASA Astrophysics Data System (ADS)

    Yao, Y.; Zhou, Y.; Liu, L.; Wang, H.; Yin, J.; You, X.; Fu, X.

    2015-04-01

    The astronomical site survey in China has been carried out since 2003. Remote studies and local surveys are performed over the high plateaus, and candidate sites have been selected and performed site testing measurements. The monitoring results show that Ali area in western Tibet can be the best choice for astronomical observations over East Asian regions. Ali site, near the central town of Ali area, has been further identified for small telescope projects and simultaneously for detailed site characterization, and begun construction in 2010. This paper presents the site monitoring strategy and site development plan of the new Ali observatory.

  16. Remembering for tomorrow: Professor Mansour Ali Haseeb.

    PubMed

    Salih, Mustafa Abdalla M

    2013-01-01

    This is a highlight of the obituary ceremony in tribute to Professor Mansour Ali Haseeb (1910 - 1973), organized by the Medical Students Association of the Faculty of Medicine, the University of Khartoum (U of K). Professor Haseeb has been the first Sudanese Professor and first Dean of the Faculty of Medicine. He was an outstanding humane teacher, mentor and researcher, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO. He was also an active citizen in public life and became Mayor of Omdurman City. The obituary ceremony reflected the feelings of the medical community and included speeches by Professor Abdalla El Tayeb, President of U of K; the Dean, Faculty of Medicine; the Late Professor Haseeb's colleagues and students, His family representative, and an elegy poem.

  17. Remembering for tomorrow: Professor Mansour Ali Haseeb

    PubMed Central

    Salih, Mustafa Abdalla M

    2013-01-01

    This is a highlight of the obituary ceremony in tribute to Professor Mansour Ali Haseeb (1910 – 1973), organized by the Medical Students Association of the Faculty of Medicine, the University of Khartoum (U of K). Professor Haseeb has been the first Sudanese Professor and first Dean of the Faculty of Medicine. He was an outstanding humane teacher, mentor and researcher, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO. He was also an active citizen in public life and became Mayor of Omdurman City. The obituary ceremony reflected the feelings of the medical community and included speeches by Professor Abdalla El Tayeb, President of U of K; the Dean, Faculty of Medicine; the Late Professor Haseeb’s colleagues and students, His family representative, and an elegy poem. PMID:27493378

  18. Characterization of ALD grown TixAlyN and TixAlyC thin films

    NASA Astrophysics Data System (ADS)

    Kinnunen, S. A.; Malm, J.; Arstila, K.; Lahtinen, M.; Sajavaara, T.

    2017-09-01

    Atomic layer deposition (ALD) was used to grow TixAlyN and TixAlyC thin films using trimethylaluminum (TMA), titanium tetrachloride and ammonia as precursors. Deposition temperature was varied between 325 °C and 500 °C. Films were also annealed in vacuum and N2-atmosphere at 600-1000 °C. Wide range of characterization methods was used including time-of-flight elastic recoil detection analysis (ToF-ERDA), X-ray diffractometry (XRD), X-ray reflectometry (XRR), Raman spectroscopy, ellipsometry, helium ion microscopy (HIM), atomic force microscopy (AFM) and 4-point probe measurement for resistivity. Deposited films were roughly 100 nm thick and contained mainly desired elements. Carbon, chlorine and hydrogen were found to be the main impurities.

  19. The Hall-Rodriguez theory of latent inhibition: Further assessment of compound stimulus preexposure effects.

    PubMed

    Rodríguez, Gabriel; Márquez, Raúl; Gil, Marta; Alonso, Gumersinda; Hall, Geoffrey

    2014-10-01

    According to a recent theory (Hall & Rodriguez, 2010), the latent inhibition produced by nonreinforced exposure to a target stimulus (B) will be deepened by subsequent exposure of that stimulus in compound with another (AB). This effect of compound exposure is taken to depend on the addition of a novel A to the familiar B and is not predicted for equivalent preexposure on which AB trials precede the A trials. This prediction was tested in 2 experiments using rats. Experiment 1 used an aversive procedure with flavors as the stimuli; Experiment 2 used an appetitive procedure with visual and auditory stimuli. In both, we found that conditioning with B as the conditioned stimulus proceeded more slowly (i.e., latent inhibition was greater) in subjects given the B-AB sequence in preexposure than in subjects given the AB-B sequence.

  20. VizieR Online Data Catalog: ubvyHβ photometry of AB Cas (Rodriguez+ 1998)

    NASA Astrophysics Data System (ADS)

    Rodriguez, E.; Claret, A.; Sedano, J. L.; Garcia, J. M.; Garrido, R.

    1998-09-01

    Table 1 contents 471 simultaneous measurements collected in each of the four uvby colours of the Stroemgren photometric system for the eclipsing binary system AB Cas. Because of an instrumental problem, 82 points in the b channel (during the last observational night) had to be rejected (the corresponding magnitudes are listed as 0.0000). The data are magnitude differences (Du,Dv,Db,Dy) of the variable star minus comparison star in the instrumental system versus Heliocentric Julian Day. Table 2 is the same, but for Hβ (80 points). The comparison star is BD+70 0188. The origin in time is the Julian Day 2447117. The observations were carried out (by E. Rodriguez, A. Claret, J.L. Sedano, J.M. Garcia and R. Garrido) during 1987 and 1988 using the 0.90m telescope at the Sierra Nevada Observatory, Spain. (2 data files).

  1. A further assessment of the Hall-Rodriguez theory of latent inhibition.

    PubMed

    Leung, Hiu Tin; Killcross, A S; Westbrook, R Frederick

    2013-04-01

    The Hall-Rodriguez (G. Hall & G. Rodriguez, 2010, Associative and nonassociative processes in latent inhibition: An elaboration of the Pearce-Hall model, in R. E. Lubow & I. Weiner, Eds., Latent inhibition: Data, theories, and applications to schizophrenia, pp. 114-136, Cambridge, England: Cambridge University Press) theory of latent inhibition predicts that it will be deepened when a preexposed target stimulus is given additional preexposures in compound with (a) a novel stimulus or (b) another preexposed stimulus, and (c) that deepening will be greater when the compound contains a novel rather than another preexposed stimulus. A series of experiments studied these predictions using a fear conditioning procedure with rats. In each experiment, rats were preexposed to 3 stimuli, 1 (A) taken from 1 modality (visual or auditory) and the remaining 2 (X and Y) taken from another modality (auditory or visual). Then A was compounded with X, and Y was compounded with a novel stimulus (B) taken from the same modality as A. A previous series of experiments (H. T. Leung, A. S. Killcross, & R. F. Westbrook, 2011, Additional exposures to a compound of two preexposed stimuli deepen latent inhibition, Journal of Experimental Psychology: Animal Behavior Processes, Vol. 37, pp. 394-406) compared A with Y, finding that A was more latently inhibited than Y, the opposite of what was predicted. The present experiments confirmed that A was more latently inhibited than Y, showed that this was due to A entering the compound more latently inhibited than Y, and finally, that a comparison of X and Y confirmed the 3 predictions made by the theory.

  2. Evaluation test of ALIS in Cambodia for humanitarian demining

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki

    2010-04-01

    ALIS is a hand-held dual sensor developed by Tohoku University, Japan since 2002. Dual sensor is a general name of sensor for humanitarian demining, which are equipped with metal detector and GPR. ALIS is only one hand-held dual sensor, which can record the sensor position with sensor signals. Therefore, the data can be processed after data acquisition, and can increase the imaging capability. ALIS has been tested in some mine affected courtiers including Afghanistan (2004), Egypt(2005), Croatia(2006-) and Cambodia(2007-). Mine fields at each country has different conditions and soil types. Therefore testes at the real mine fields are very important. ALIS has detected more than 30 AP-Mines in evaluation test in Cambodia held in 2009.

  3. AliEn—ALICE environment on the GRID

    NASA Astrophysics Data System (ADS)

    Saiz, P.; Aphecetche, L.; Bunčić, P.; Piskač, R.; Revsbech, J.-E.; Šego, V.; Alice Collaboration

    2003-04-01

    AliEn ( http://alien.cern.ch) (ALICE Environment) is a Grid framework built on top of the latest Internet standards for information exchange and authentication (SOAP, PKI) and common Open Source components. AliEn provides a virtual file catalogue that allows transparent access to distributed datasets and a number of collaborating Web services which implement the authentication, job execution, file transport, performance monitor and event logging. In the paper we will present the architecture and components of the system.

  4. Modernizing "San Antonio Independent School District v. Rodriguez": How Evolving Supreme Court Jurisprudence Changes the Face of Education Finance Litigation

    ERIC Educational Resources Information Center

    Saleh, Matthew

    2011-01-01

    This article aims to "modernize" the current legal debate over inequitable public school funding at the state and local level. The 1973 Supreme Court case of "San Antonio Independent School District v. Rodriguez" established precedent, allowing for property-tax based education funding programs at the state-level--a major source…

  5. Modernizing "San Antonio Independent School District v. Rodriguez": How Evolving Supreme Court Jurisprudence Changes the Face of Education Finance Litigation

    ERIC Educational Resources Information Center

    Saleh, Matthew

    2011-01-01

    This article aims to "modernize" the current legal debate over inequitable public school funding at the state and local level. The 1973 Supreme Court case of "San Antonio Independent School District v. Rodriguez" established precedent, allowing for property-tax based education funding programs at the state-level--a major source…

  6. Rodriguez Recognized as Recipient of the MSSS AACC Chair’s Inspirational Award | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    Dr. Henry Rodriguez, director of the Office of Cancer Clinical Proteomics Research, has been recognized as the recipient of the Chair’s Inspirational Award by the Mass Spectrometry and Separation Sciences for Laboratory Medicine Division (MSSS), American Association for Clinical Chemistry (AACC).

  7. Features of electronic structure of hypovalent lithides ALi/sub k/ and ALi/sub k+1//sup +/

    SciTech Connect

    Klimenko, N.M.; Mebel', A.M.; Charkin, O.P.

    1988-11-01

    The features of the chemical bonding and the behavior of the original energies of the lithides ALi/sub k/ and ALi/sub K+1//sup +/ have been analyzed on the basis of nonempirical calculations in the MP3/(DZHD + P/sub A/) approximation. It has been found that the new A-Li bond appearing upon the addition of Li/sup +/ to Ali/sub k/ is formed with the participation of only the p/sub A/ AO's from the atom A. In contrast to the case of the hydrides AK/sub k/ and the fluorides AF/sub k/, in the case of the lithides ALi/sub k/ and ALi/sub k+1//sup +/, the lone pair of the atom A consists of its almost pure s/sub A/ AO, which maintains its spherical shape, is not active stereochemically, and practically does not participate in the bonding. The lithides ALi/sub k/ and Ali/sub k+1//sup +/ (such as CLi/sub 2/, Cli/sub 3//sup +/, NLi/sub 3/, NLi/sub 4//sup +/, OLi/sub 2/, OLi/sub 3//sup +/, Fli, Fli/sub 2//sup +/, etc.) may be classified as hypovalent compounds, in which the number of valence AO's of the atom A participating in the bonding is smaller than the number of atoms of Li directly bonded to the atom A. The bonding in them is delocalized over all the atoms comparing the molecule, and the two-center approach and Gillespie's rules are, in principle, not suitable.

  8. Prognostic Significance of Modified Advanced Lung Cancer Inflammation Index (ALI) in Patients with Small Cell Lung Cancer_ Comparison with Original ALI

    PubMed Central

    Kim, Young Saing; Seo, Ja-Young; Park, Inkeun; Ahn, Hee Kyung; Jeong, Yu Mi; Kim, Jeong Ho

    2016-01-01

    Background Advanced lung cancer inflammation index (ALI, body mass index [BMI] x serum albumin/neutrophil-lymphocyte ratio [NLR]) has been shown to predict overall survival (OS) in small cell lung cancer (SCLC). CT enables skeletal muscle to be quantified, whereas BMI cannot accurately reflect body composition. The purpose was to evaluate prognostic value of modified ALI (mALI) using CT-determined L3 muscle index (L3MI, muscle area at L3/height2) beyond original ALI. Methods L3MIs were calculated using the CT images of 186 consecutive patients with SCLC taken at diagnosis, and mALI was defined as L3MI x serum albumin/NLR. Using chi-squared test determined maximum cut-offs for low ALI and low mALI, the prognostic values of low ALI and low mALI were tested using Kaplan-Meier method and Cox proportional hazards analysis. Finally, deviance statistics was used to test whether the goodness of fit of the prognostic model is improved by adding mALI as an extra variable. Results Patients with low ALI (cut-off, 31.1, n = 94) had shorter OS than patients with high ALI (median, 6.8 months vs. 15.8 months; p < 0.001), and patients with low mALI (cut-off 67.7, n = 94) had shorter OS than patients with high mALI (median, 6.8 months vs. 16.5 months; p < 0.001). There was no significant difference in estimates of median survival time between low ALI and low mALI (z = 0.000, p = 1.000) and between high ALI and high mALI (z = 0.330, p = 0.740). Multivariable analysis showed that low ALI was an independent prognostic factor for shorter OS (HR, 1.67, p = 0.004), along with advanced age (HR, 1.49, p = 0.045), extensive disease (HR, 2.27, p < 0.001), supportive care only (HR, 7.86, p < 0.001), and elevated LDH (HR, 1.45, p = 0.037). Furthermore, goodness of fit of this prognostic model was not significantly increased by adding mALI as an extra variable (LR difference = 2.220, p = 0.136). Conclusion The present study confirms mALI using CT-determined L3MI has no additional prognostic

  9. Site Protection Program and Progress Report of Ali Observatory, Tibet

    NASA Astrophysics Data System (ADS)

    Yao, Yongqiang; Zhou, Yunhe; Wang, Xiaohua; He, Jun; Zhou, Shu

    2015-08-01

    The Ali observatory, Tibet, is a promising new site identified through ten year site survey over west China, and it is of significance to establish rules of site protection during site development. The site protection program is described with five aspects: site monitoring, technical support, local government support, specific organization, and public education. The long-term sky brightness monitoring is ready with site testing instruments and basic for light pollution measurement; the monitoring also includes directions of main light sources, providing periodical reports and suggestions for coordinating meetings. The technical supports with institutes and manufacturers help to publish lighting standards and replace light fixtures; the research pays special attention to the blue-rich sources, which impact the important application of high altitude sites. An official leading group towards development and protection of astronomical resources has been established by Ali government; one of its tasks is to issue regulations against light pollution, including special restrictions of airport, mine, and winter heating, and to supervise lighting inspection and rectification. A site protection office under the official group and local astronomical society are organized by Ali observatory; the office can coordinate in government levels and promote related activities. A specific website operated by the protection office releases activity propaganda, evaluation results, and technical comparison with other observatories. Both the site protection office and Ali observatory take responsibility for public education, including popular science lectures, light pollution and energy conservation education. Ali Night Sky Park has been constructed and opens in 2014, and provides a popular place and observational experience. The establishment of Ali Observatory and Night Sky Park brings unexpected social influence, and the starry sky trip to Ali becomes a new format of culture

  10. The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease.

    PubMed

    Kerr, A R; Adrian, P V; Estevão, S; de Groot, R; Alloing, G; Claverys, J-P; Mitchell, T J; Hermans, P W M

    2004-07-01

    The Ami-AliA/AliB oligopeptide permease is an ATP-binding cassette transporter which is found in Streptococcus pneumoniae and which is involved in nutrient uptake. We investigated the role of the three paralogous oligopeptide-binding lipoproteins AmiA, AliA, and AliB by using murine models of pneumococcal colonization and invasive disease. A series of mutants lacking aliA, aliB, and amiA either alone or in combination as double or triple mutations were used. Inoculation of the nasopharynx with a mixture of the obl (oligopeptide-binding lipoprotein-negative) triple-mutant and wild-type (D39) bacteria resulted in significantly smaller numbers of obl bacteria colonizing the nasopharynx. The use of a mixture of individual mutants and wild-type pneumococci revealed that AmiA, AliA, and AliB were all required for successful colonization of the nasopharynx. The obl mutant was more attenuated than the aliB mutant but not the aliA or amiA mutant. Therefore, there is some redundancy in the Ami-AliA/AliB complex in terms of nasopharyngeal colonization, with AliA and AmiA being able to compensate for the removal of AliB. Animals with invasive disease caused by these mutants had survival times, bacterial loads, and inflammatory cytokine production levels similar to those of animals infected with wild-type pneumococci. Our results show that although the Ami-AliA/AliB complex is not required for virulence during pneumococcal pneumonia, it does play a role in colonization of the nasopharynx.

  11. VizieR Online Data Catalog: HD 163151: a new W UMa type system (Rodriguez+ 1998)

    NASA Astrophysics Data System (ADS)

    Rodríguez, E.; Claret, A.; García, J. M.; Zerbi, F. M.; Garrido, R.; Martín, S.; Akan, C.; Luedeke, K.; Keskin, V.; Ibanoglu, C.; Evren, S.; Tunca, Z.; Pekunlu, R.; Paparo, M.; Nuspl, J.; Krisciunas, K.; Jiang, S. Y.

    1998-06-01

    Table 2 contains 408 simultaneous measurements collected in each of the four uvby colours of the Stromgren photometric system for the W UMa system HD 163151. The data are magnitude differences (Du, Dv, Db, Dy, D(b-y), Dm1, Dc1) of the variable star minus comparison star in the standard system versus Heliocentric Julian Day. Tables 3, 4 and 5 are the same, but for Hβ (65 points), Johnson B data (212 points) and Johnson V data (355 points). The comparison star is HD 166095. The origin in time is the Julian Day 2449858. The observations were carried out (by E. Rodriguez, A. Claret, J.M. Garcia, F.M. Zerbi, R. Garrido, S. Martin, C. Akan, K. Luedeke, V. Keskin, C. Ibanoglu, S. Evren, Z. Tunca, R. Pekunlu, M. Paparo, J. Nuspl, K. Krisciunas and S.Y. Jiang) in 1995 during the course of a multisite campaign. The following telescopes were used: 90cm telescope of the Sierra Nevada Observatory, Spain (uvby-Hβ photometry); 50cm telescope at the Ege University Observatory, Turkey (BV-uvby); 50cm telescope at Piszkesteto mountain station, Konkoly Observatory, Hungary (BV); 50cm telescope at the Merate Observatory, Italy (V); 30cm telescope at Albuquerque, New Mexico, USA (V) and 15cm telescope at Mauna Kea, Hawaii, USA (V). (4 data files).

  12. ALIS through the Looking Glass: Changing Perceptions of Performance Indicators.

    ERIC Educational Resources Information Center

    Williamson, John; And Others

    1992-01-01

    Follows up on a Williamson and Fitz-Gibbon article (1990) focusing on the impact of a performance indicator project, COMBSE (Confidential Measurement Based Self-Evaluation), on secondary school English departments. This article describes COMBSE's metamorphosis into another system, ALIS (A Level Information System), that has transcended the…

  13. Enhancing the AliEn Web Service Authentication

    NASA Astrophysics Data System (ADS)

    Zhu, Jianlin; Saiz, Pablo; Carminati, Federico; Betev, Latchezar; Zhou, Daicui; Mendez Lorenzo, Patricia; Grigoras, Alina Gabriela; Grigoras, Costin; Furano, Fabrizio; Schreiner, Steffen; Vladimirovna Datskova, Olga; Sankar Banerjee, Subho; Zhang, Guoping

    2011-12-01

    Web Services are an XML based technology that allow applications to communicate with each other across disparate systems. Web Services are becoming the de facto standard that enable inter operability between heterogeneous processes and systems. AliEn2 is a grid environment based on web services. The AliEn2 services can be divided in three categories: Central services, deployed once per organization; Site services, deployed on each of the participating centers; Job Agents running on the worker nodes automatically. A security model to protect these services is essential for the whole system. Current implementations of web server, such as Apache, are not suitable to be used within the grid environment. Apache with the mod_ssl and OpenSSL only supports the X.509 certificates. But in the grid environment, the common credential is the proxy certificate for the purpose of providing restricted proxy and delegation. An Authentication framework was taken for AliEn2 web services to add the ability to accept X.509 certificates and proxy certificates from client-side to Apache Web Server. The authentication framework could also allow the generation of access control policies to limit access to the AliEn2 web services.

  14. ALI--A Digital Archive of DAISY Books

    ERIC Educational Resources Information Center

    Forsberg, Asa

    2007-01-01

    ALI is a project to develop an archive for talking books produced by the Swedish universities. The universities produce talking books from the mandatory literature for students with reading disabilities, including mostly journal articles, book chapters and texts written by teachers. The project group consists of librarians and co-ordinators for…

  15. Sidi Ali Ou Azza (L4): A New Moroccan Fall

    NASA Astrophysics Data System (ADS)

    Chennaoui Aoudjehane, H.; Agee, C. B.; Aaranson, A.; Bouragaa, A.

    2016-08-01

    Sidi Ali Ou Azza is the latest meteorite fall in Morocco, it occurred on 28 July 2015 very close (about 40 km) to Tissint martian shergottite fall that occurred on 18 July 2011. It's one of the small group of 23 L4 ordinary chondrite falls.

  16. ALI--A Digital Archive of DAISY Books

    ERIC Educational Resources Information Center

    Forsberg, Asa

    2007-01-01

    ALI is a project to develop an archive for talking books produced by the Swedish universities. The universities produce talking books from the mandatory literature for students with reading disabilities, including mostly journal articles, book chapters and texts written by teachers. The project group consists of librarians and co-ordinators for…

  17. ALIS through the Looking Glass: Changing Perceptions of Performance Indicators.

    ERIC Educational Resources Information Center

    Williamson, John; And Others

    1992-01-01

    Follows up on a Williamson and Fitz-Gibbon article (1990) focusing on the impact of a performance indicator project, COMBSE (Confidential Measurement Based Self-Evaluation), on secondary school English departments. This article describes COMBSE's metamorphosis into another system, ALIS (A Level Information System), that has transcended the…

  18. Seismicity at the Kairei Hydrothermal Vent Field Near the Rodriguez Triple Junction in the Indian Ocean

    NASA Astrophysics Data System (ADS)

    Sato, T.; Takata, H.; Imai, Y.; Mori, T.; Noguchi, Y.; Kono, A.; Yamada, T.; Shinohara, M.

    2014-12-01

    1. Introduction In the first segment of the central Indian Ridge from the Rodriguez triple junction, the Kairei hydrothermal vent field exists and extrudes hydrothermal fluid with richer hydrogen content compared to other hydrothermal vents in the world. Around the Kairei hydrothermal field, serpentinized peridotite and troctolites, and gabbroic rocks were discovered. These deep-seated rocks exposed around the Kairei field may cause the enrichment of H2 in the Kairei fluids. At the Kairei field, a hydrogen-based subsurface microbial ecosystem and various hydrothermal vent macrofauna were found. In the "TAIGA" Project (Trans-crustal Advection and In situ reaction of Global sub-seafloor Aquifer), this area is a representative field of "TAIGA" of hydrogen. To investigate how the deep-seated rocks (originally situated at several kilometers below seafloor) are uplifted and exposed onto seafloor, and the hydrothermal fluids circulate in subsurface, we conducted a seismic refraction/reflection survey and seismicity observation with ocean bottom seismometers (OBSs). This presentation will show seismicity of the survey area. 2. Observation and results We conducted a seismic survey around the Kairei hydrothermal field from January 27 to March 19 in 2013 using S/V Yokosuka of Jamstec. We used 21 OBSs. From the 50 days seismicity observation, we found many micro earthquakes in this area. A swarm of micro earthquakes exists at a location about 1 km northwest of the Kairei field. The swarm has a NNW-SSE strike, parallel to the ridge axis. The depth of the swarm is very shallow (~4 km from seafloor). This swarm may be related to the hydrothermal activities of the Kairei field. At the first segment of the central Indian Ridge, many micro earthquakes occurred. The depth of these events is deeper than that of the swarm near the Kairei field.

  19. Geochemistry of the mantle beneath the Rodriguez Triple Junction and the South-East Indian Ridge

    NASA Astrophysics Data System (ADS)

    Michard, A.; Montigny, R.; Schlich, R.

    1986-05-01

    Rare earth element abundances and Sr, Nd. Pb isotope compositions have been measured on zero-age dredge samples from the Rodriguez Triple Junction (RTJ) and the South-East Indian Ridge (SEIR), Along the SEIR. the geochemical "halo" of the St. Paul hot spot has a half-width of about 400 km and the data may be fairly well accounted for by a binary mixing between an Indian MORB-type component ( 87Sr/ 86Sr = 0.7028. 143Nd/ 144Nd = 0.51304. 206Pb/ 204Pb = 17.8) and the plume-type St. Paul component (0.7036, 0.5129, and 18.7 respectively). The alignment of the lead isotope data is particularly good with an apparent age of 1.95 ± 0.13 Ga and Th/U source value of 3.94. One sample dredged on the ridge 60 km southeast of St. Paul bears a definite Kerguelen isotopic signature. The RTJ has distinctive geochemical properties which contrast with those of the adjacent ridge segments. Low 206Pb/ 204Pb ratios which plots to the left of the geochron, rather high 208Pb/ 204Pb and 87Sr/ 87Sr ratios (17.4. 37.4, and 0.7031 respectively), a striking isotopic homogeneity, and variable LREE/HREE fractionation with (La/Sm) N, = 0.3-0.8 make this triple junction an anomalous site. The geochemical properties of the Indian Ocean basats have been examined using a three-component mantle model involving (a) a normal MORB-type source though to represent the depleted upper mantle matrix, (b) an OIB-type source of uncertain parentage (recycled oceanic crust?), and (c) a component with low μ. low Sm/Nd. high Rb/Sr (time-averaged value) which is tentatively assigned to ancient hydrothermal and abyssal sediments recycled in the mantle. The high 208Pb/ 204Pb and 87Sr/ 86Sr ratios typical of the Dupal anomaly are likely due to the widespread distribution of this latter component in the basalt source from this area. including that for MORBs.

  20. Rodriguez Segment of the Central Indian Ridge: Hotspot-ridge interaction and hydrothermal activity

    NASA Astrophysics Data System (ADS)

    Tamaki, K.; Ura, T.

    2008-12-01

    We conducted R/V Hakuho-maru KH-06-04 Research Cruise (2006/2007) at the Rodriguez Segment of the Central Indian Ridge with geophysical mapping by SeaBeam, magnetics, and gravity, AUV (Autonomous Underwater Vehicle) dives, CTD hydrocasts, and rock samplings. The principal results of the cruise are summarized as follows. (1) Success of the dives by AUV at the axis of mid-oceanic ridge AUV, r2D4, developed by the Institute of Industrial Sciences, University of Tokyo, successfully dived at the axial part of the IR at its 2800 m water depth and collected high- resolution side scan sonar images, interferometric bathymetry, anomalies of manganese components in the sea water, geomagnetic data, and others. The diving at the Segment 16 of CIR was especially successful with complete sidescan sonar mapping of a large lava plain at the axial rift zone that was named as Great Dodo Lava Plain and the finding of possible hydrothermal site by a realtime manganese analyzer (GAMOS) installed on the AUV. (2) Findings of two hydrothermal sites. Two possible active hydrothermal sites are newly found during the cruise by the CTD operation and AUV operation. One is in the Segment 15 and the other is in the Segment 16. Although further surveys by ROV or submersible are necessary, the intensive signals of manganese anomaly in the deepsea water suggest strong possibility of existence of active hydrothermal sites. (3) High resolution mapping of the axial rift of CIR High resolution bathymetric mapping of the axial rift zones of Segments 15 , 16 , 17 and 18 was achieved by high frequency multi narrow beam bathymetric mapping system with a sonic frequency of 20kHz and beam width of 1 degree. The resultant mapping of 50 m grid may be one the best quality mapping of the mid-oceanic ridges in the world. (4) Pinpoint identification of the contact the Reunion Hotspot plume and CIR spreading axis Very contact of the eastern extension of the Gastiao Ridge and the axial volcanic chain of the Segment

  1. AliBaba: PubMed as a graph.

    PubMed

    Plake, Conrad; Schiemann, Torsten; Pankalla, Marcus; Hakenberg, Jörg; Leser, Ulf

    2006-10-01

    The biomedical literature contains a wealth of information on associations between many different types of objects, such as protein-protein interactions, gene-disease associations and subcellular locations of proteins. When searching such information using conventional search engines, e.g. PubMed, users see the data only one-abstract at a time and 'hidden' in natural language text. AliBaba is an interactive tool for graphical summarization of search results. It parses the set of abstracts that fit a PubMed query and presents extracted information on biomedical objects and their relationships as a graphical network. AliBaba extracts associations between cells, diseases, drugs, proteins, species and tissues. Several filter options allow for a more focused search. Thus, researchers can grasp complex networks described in various articles at a glance. http://alibaba.informatik.hu-berlin.de/

  2. Contemporary ventilator management in patients with and at risk of ALI/ARDS.

    PubMed

    Chang, Steven Y; Dabbagh, Ousama; Gajic, Ognen; Patrawalla, Amee; Elie, Marie-Carmelle; Talmor, Daniel S; Malhotra, Atul; Adesanya, Adebola; Anderson, Harry L; Blum, James M; Park, Pauline K; Gong, Michelle Ng

    2013-04-01

    Ventilator practices in patients at risk for acute lung injury (ALI) and ARDS are unclear. We examined factors associated with choice of set tidal volumes (VT), and whether VT < 8 mL/kg predicted body weight (PBW) relates to the development of ALI/ARDS. We performed a secondary analysis of a multicenter cohort of adult subjects at risk of lung injury with and without ALI/ARDS at onset of invasive ventilation. Descriptive statistics were used to describe ventilator practices in specific settings and ALI/ARDS risk groups. Logistic regression analysis was used to determine the factors associated with the use of VT < 8 mL/kg PBW and the relationship of VT to ALI/ARDS development and outcome. Of 829 mechanically ventilated patients, 107 met the criteria for ALI/ARDS at time of intubation, and 161 developed ALI/ARDS after intubation (post-intubation ALI/ARDS). There was significant intercenter variability in initial ventilator settings, and in the incidence of ALI/ARDS and post-intubation ALI/ARDS. The median VT was 7.96 (IQR 7.14-8.94) mL/kg PBW in ALI/ARDS subjects, and 8.45 (IQR 7.50-9.55) mL/kg PBW in subjects without ALI/ARDS (P = .004). VT decreased from 8.40 (IQR 7.38-9.37) mL/kg PBW to 7.97 (IQR 6.90-9.23) mL/kg PBW (P < .001) in those developing post-intubation ALI/ARDS. Among subjects without ALI/ARDS, VT ≥ 8 mL/kg PBW was associated with shorter height and higher body mass index, while subjects with pneumonia were less likely to get ≥ 8 mL/kg PBW. Initial VT ≥ 8 mL/kg PBW was not associated with the post-intubation ALI/ARDS (adjusted odds ratio 1.30, 95% CI 0.74-2.29) or worse outcomes. Post-intubation ALI/ARDS subjects had mortality similar to subjects intubated with ALI/ARDS. Clinicians seem to respond to ALI/ARDS with lower initial VT. Initial VT, however, was not associated with the development of post-intubation ALI/ARDS or other outcomes.

  3. Predictive criteria to study the pathogenesis of malaria-associated ALI/ARDS in mice.

    PubMed

    Ortolan, Luana S; Sercundes, Michelle K; Barboza, Renato; Debone, Daniela; Murillo, Oscar; Hagen, Stefano C F; Russo, Momtchilo; D' Império Lima, Maria Regina; Alvarez, José M; Amaku, Marcos; Marinho, Claudio R F; Epiphanio, Sabrina

    2014-01-01

    Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS) often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP) were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF) levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration) and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease.

  4. Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice

    PubMed Central

    Ortolan, Luana S.; Sercundes, Michelle K.; Debone, Daniela; Hagen, Stefano C. F.; D' Império Lima, Maria Regina; Alvarez, José M.; Marinho, Claudio R. F.; Epiphanio, Sabrina

    2014-01-01

    Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS) often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP) were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF) levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration) and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease. PMID:25276057

  5. Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS

    PubMed Central

    Pereira, Marcelo L. M.; Ortolan, Luana S.; Sercundes, Michelle K.; Debone, Daniela; Murillo, Oscar; Lima, Flávia A.

    2016-01-01

    Malaria is a serious disease, caused by the parasite of the genus Plasmodium, which was responsible for 440,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA/2 reproduces the clinical signs of ALI/ARDS in humans, when infected with Plasmodium berghei ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI/ARDS (MA-ALI/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI/ARDS when administered prior to the development of MA-ALI/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI/ARDS could be protective. However, the increased expression of HO-1 on the onset of MA-ALI/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI/ARDS in humans. PMID:27974865

  6. Volcanic Rocks Collected With ROV Tiburon From Rodriguez Seamount, Located at the Continental Slope of the California Borderland

    NASA Astrophysics Data System (ADS)

    Davis, A. S.; Clague, D. A.; Paduan, J. B.

    2004-12-01

    Volcanic rocks were collected from Rodriguez Seamount at the outer margin off the Continental Borderland with MBARI's ROV Tiburon in October 2003 and April 2004. Six dives recovered lava and volcaniclastic samples from the deep flanks ( ˜2120 m) to the summit at 630 m. Whole rock compositions of plagioclase-olivine-clionpyroxene bearing lava samples are predominantly alkalic basalt (<8% MgO) and hawaiite with minor mugearite (MgO=1.5%). Glass compositions of pillow rims and of volcaniclastic fragments in breccia and bedded sandstone are predominantly hawaiite, mugearite and minor evolved alkalic basalt. The lava samples include one rhyolite and one basaltic andesite with subduction-related chemistry; they are probably erratics. Other clearly identifiable erratics include granite, quartzite, amphibolite, and bored, erosion-sculpted sandstone, resembling typical beach deposits. Most of these erratics are pebble- to small cobble-size and occur in conglomerate and crossbedded sandstone that surround the summit at a break in slope that most likely marks the shoreline when Rodriguez was an island. The lava outcrops on the gently domed platform of the summit are dense, oxidized àà-like flows without glassy rinds. Sulfur content of glass, collected from the flanks of the volcano, ranges from 1300 ppm of a glass inclusion in an olivine crystal to ˜160 ppm of volcaniclastic grains, indicating extensive degassing. Petrographically and chemically these lavas are virtually identical to those erupted on Miocene seamounts offshore central California (e.g. Davidson, Guide, Pioneer, Gumdrop seamounts, Davis et al, 2002) as well as Northeast Bank on the continental shelf south of Rodriguez and seamounts farther offshore from the Continental Borderland (e.g. Little Joe, San Marcos, San Juan seamounts, Clague et al, unpublished; Davis et al., 1995). Trace element abundances and ratios (e.g. LREE, Zr/Nb, Ta/Nb) also completely overlap with those from the other sites, suggesting

  7. Optical Turbulence Characterization by WRF model above Ali, Tibet

    NASA Astrophysics Data System (ADS)

    Wang, Hongshuai; Yao, Yongqiang; Liu, Liyong; Qian, Xuan; Yin, Jia

    2015-04-01

    Atmospheric optical turbulence modeling and forecast for astronomy is a relatively recent discipline, but has played important roles in site survey, optimization of large telescope observing tables, and in the applications of adaptive optics technique. The numerical approach, by using of meteorological parameters and parameterization of optical turbulence, can provide all the optical turbulence parameters related, such as C2n profile, coherent length, wavefront coherent time, seeing, isoplanatic angle, and so on. This is particularly interesting for searching new sites without the long and expensive site testing campaigns with instruments. Earlier site survey results by the site survey team of National Astronomical Observatories of China imply that the south-west Tibet, Ali, is one of the world best IR and sub-mm site. For searching the best site in Ali area, numerical approach by Weather and Research Forecasting (WRF) model had been used to evaluate the climatology of the optical turbulence. The WRF model is configured over a domain 200km×200km with 1km horizontal resolution and 65 vertical levels from ground to the model top(10millibars) in 2010. The initial and boundary conditions for the model are provided by the 1° × 1° Global Final Analysis data from NCEP. The distribution and seasonal variation of optical turbulence parameters over this area are presented.

  8. [Advance on human umbilical cord mesenchymal stem cells for treatment of ALI in severe burns].

    PubMed

    Wang, Yu; Hu, Xiaohong

    2017-01-01

    Severe burn is often accompanied by multiple organ damage. Acute lung injury (ALI) is one of the most common complications, and often occurs in the early stage of severe burns. If it is not treated in time, it will progress to acute respiratory distress syndrome (ARDS), which will be a serious threat to the lives of patients. At present, the treatment of ALI in patients with severe burn is still remained in some common ways, such as the liquid resuscitation, the primary wound treatment, ventilation support, and anti-infection. In recently, human umbilical cord mesenchymal stem cells (hUCMSCs) have been found having some good effects on ALI caused by various causes, but few reports on the efficacy of ALI caused by severe burns were reported. By reviewing the mechanism of stem cell therapy for ALI, therapeutic potential of hUCMSCs in the treatment of severe burns with ALI and a new approach for clinical treatment was provided.

  9. Spatial resolution enhancement of EO-1 ALI bands

    NASA Astrophysics Data System (ADS)

    Nikolakopoulos, Konstantinos G.

    2006-09-01

    spectral characteristics, they do not take into account the resolution ratio of the input images. Usually the spatial resolution of the panchromatic image is two (Landsat 7, Spot 1-4) or four times (Ikonos, Quickbird) better than the size of the multispectral images. This paper is an attempt to fuse high-resolution panchromatic and low-resolution multispectral bands of the EO-1 ALI sensor. ALI collects nine multispectral bands with 30m resolution and a panchromatic band with 3 times better resolution (10m). ALI has a panchromatic band narrower than the respective band of Landsat7. It has also two narrower bands in the spectral range of Landsat7 band 4. It has also an extra narrower band near the spectral range of Landsat7 band 1. In this study we compare the efficiency of seven fusion techniques and more especially the efficiency of Gram Schmidt, Modified IHS, PCA, Pansharp, Wavelet and LMM (Local Mean Matching) LMVM (Local Mean and Variance Matching) fusion techniques for the fusion of ALI data. Two ALI images collected over the same area have been used. In order to quantitatively measure the quality of the fused images we have made the following controls: Firstly, we have examined the optical qualitative result. Then, we examined the correlation between the original multispectral and the fused images and all the statistical parameters of the histograms of the various frequency bands. All the fusion techniques improve the resolution and the optical result. In contrary to the fusion of other data (ETM, Spot5, Ikonos and Quickbird) all the algorithms provoke small changes to the statistical parameters.

  10. Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis

    PubMed Central

    Nevarez, Lisette; Pogue, Robert; Krakow, Deborah; Cohn, Daniel H.

    2016-01-01

    The acrofacial dysostoses (AFD) are a genetically heterogeneous group of inherited disorders with craniofacial and limb abnormalities. Rodriguez syndrome is a severe, usually perinatal lethal AFD, characterized by severe retrognathia, oligodactyly and lower limb abnormalities. Rodriguez syndrome has been proposed to be a severe form of Nager syndrome, a non-lethal AFD that results from mutations in SF3B4, a component of the U2 small nuclear ribonucleoprotein particle (U2 snRNP). Furthermore, a case with a phenotype intermediate between Rodriguez and Nager syndromes has been shown to have an SF3B4 mutation. We identified heterozygosity for SF3B4 mutations in Rodriguez syndrome, confirming that the phenotype is a dominant disorder that is allelic with Nager syndrome. The mutations led to reduced SF3B4 synthesis and defects in mRNA splicing, primarily exon skipping. The mutations also led to reduced expression in growth plate chondrocytes of target genes, including the DLX5, DLX6, SOX9, and SOX6 transcription factor genes, which are known to be important for skeletal development. These data provide mechanistic insight toward understanding how SF3B4 mutations lead to the skeletal abnormalities observed in the acrofacial dysostoses. PMID:27622494

  11. The States and School Finance--After Rodriguez. A Background Paper for the National Governors' Conference and the National Legislative Conference.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO. Dept. of Research and Information Services.

    This publication examines a number of key issues and recent trends related to the general topic of school finance. Chapter 1 reviews several significant court cases challenging state school finance systems, including San Antonio Independent School District v. Rodriguez, Robinson v. Cahill, and Serrano v. Priest. Chapter 2 describes major new…

  12. The States and School Finance--After Rodriguez. A Background Paper for the National Governors' Conference and the National Legislative Conference.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO. Dept. of Research and Information Services.

    This publication examines a number of key issues and recent trends related to the general topic of school finance. Chapter 1 reviews several significant court cases challenging state school finance systems, including San Antonio Independent School District v. Rodriguez, Robinson v. Cahill, and Serrano v. Priest. Chapter 2 describes major new…

  13. Pioneers of paediatrics: Professor Salah Abdelrahman Ali Taha

    PubMed Central

    2013-01-01

    This article highlights the contributions of Professor Salah Abdelrahman Ali Taha (1927–1988), one of the pioneers in paediatrics in Sudan and Saudi Arabia. He graduated from Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum[U of K]) in 1952 and was awarded an MD from the U of K in 1973, having accomplished a survey on the prevalence and underlying causes of childhood malnutrition in 14 villages. His impact was remarkable in establishing child health services in Sudan and Saudi Arabia, and in laying the foundation of the Department of Pediatrics, College of Medicine, King Saud University. He was also an active researcher in various fields in child health, and was pioneering in those related to nutrition. Following his return to Sudan, Dr Salah A Taha was elected Member of Parliament from his rural district in Gezira State and was the Speaker of the House of Parliament in 1986. PMID:27493360

  14. Muhammad Ali's Fighting Words: The Paradox of Violence in Nonviolent Rhetoric

    ERIC Educational Resources Information Center

    Gorsevski, Ellen W.; Butterworth, Michael L.

    2011-01-01

    While Muhammad Ali has been the subject of countless articles and books written by sports historians and journalists, rhetorical scholars have largely ignored him. This oversight is surprising given both the tradition of social movement scholarship within rhetorical studies and Ali's influential eloquence as a world renowned celebrity espousing…

  15. Muhammad Ali's Fighting Words: The Paradox of Violence in Nonviolent Rhetoric

    ERIC Educational Resources Information Center

    Gorsevski, Ellen W.; Butterworth, Michael L.

    2011-01-01

    While Muhammad Ali has been the subject of countless articles and books written by sports historians and journalists, rhetorical scholars have largely ignored him. This oversight is surprising given both the tradition of social movement scholarship within rhetorical studies and Ali's influential eloquence as a world renowned celebrity espousing…

  16. Supra-subduction zone magmatism of the Koçali ophiolite, SE Turkey

    NASA Astrophysics Data System (ADS)

    Beyarslan, Melahat

    2017-05-01

    The Late Cretaceous Koçali ophiolite is an important element within the southeastern Anatolian ophiolite belt and contains all components of a complete ophiolite, including mantle peridotites (harzburgites, and subordinate dunite) gabbros, sheeted dyke complexes, lower volcanic unit (pillowed basalts), and upper volcanic unit (andesite and andesitic pyroclastics) plagiogranite and ultramafic rocks intruded into the gabbros. All components of the Koçali ophiolites show strong suprasubduction-zone affinities, from harzburgitic mantle to basaltic lavas. The radiolarian faunas and geochronological data indicate that there are two different volcanic units: Tarasa volcanics and volcanics of the Koçali ophiolite. While the Tarasa volcanics are of Carnian to Rhaetian age, the Koçali ophiolite is of the Late Cretaceous age. The geochemical features indicate an E-MORB source for the Tarasa volcanics, and a forearc source for the Koçali ophiolite.

  17. Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials.

    PubMed

    Janz, David R; Ware, Lorraine B

    2013-08-01

    Despite the high incidence and poor prognosis of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), it remains challenging to identify patients who are at highest risk of developing these syndromes, differentiate these syndromes from other causes of acute respiratory failure, and accurately prognosticate once the diagnosis is made. The identification and validation of biological markers of ALI has the potential to ameliorate these challenges by facilitating studies of therapies aimed at prevention, identifying patients more accurately that have ALI so they can benefit from evidence-based therapies and enrollment in clinical trials, and determining which patients are unlikely to have a positive outcome to guide therapeutic choices and trials of experimental rescue therapies. This article reviews the current state of biomarker research in ALI/ARDS. New methodologies for identification of novel biomarkers of ALI, including metabolomics, proteomics, gene expression, and genetic studies are also discussed.

  18. Seismic structure at the Kairei Hydrothermal vent field near the Rodriguez Triple Junction in the Indian Ocean

    NASA Astrophysics Data System (ADS)

    Takata, H.; Sato, T.; Imai, Y.; Mori, T.; Noguchi, Y.; Kono, A.; Yamada, T.; Shinohara, M.

    2014-12-01

    Central Indian Ridge is located at the north of the Rodriguez Triple Junction and shows slow-intermediate spreading rate. The Kairei hydrothermal Field (KHF) was discovered in the first segment of Central Indian Ridge near the Rodriguez Triple Junction. The vent fluid which is extruding at the KHF has higher H2 content compared with other hydrothermal vent fluid in the world. Although The KHF itself exists above a basaltic rock massif, gabbro and mafic rocks were discovered on the seafloor around the KHF. These deep-seated rocks may contribute to the high H2concentration of the Kairei vent fluid .To understand how gabbro and mafic rocks are uplifted and exhumed on the seafloor, we conducted a seismic refraction/reflection survey using ocean bottom seismograms (OBSs). We conducted the seismic refraction/reflection survey from January 27 to March 19 in 2013 using S/V Yokosuka of Jamstec. In the experiment, we used 21 OBSs, an air gun (G.I.gun) and a single channel steamer cable. We obtained 5 survey lines NNW-SSE direction parallel to the ridge axis, 5 lines E-W direction and 5 lines NNE-SSW direction. In addition to these lines, we acquired other 5 lines passing through the point above the KHF or Yokoniwa Rise, which is the north of the KHF. In analysis of refraction data, firstly, we estimated 2D velocity model under survey lines, which are parallel to the ridge axis, using the progressive model development method developed by Sato and Kennett (2000). Then, we constructed a 3D initial model and run the 3D tomographic method developed by Zelt and Barton (1998). The 1D velocity profile of the KHF seems to be similar to that of mid ocean ridges such as Mid Atlantic Ridge, East Pacific Rise. Seismic velocities under the KHF and Yokoniwa Rise reach about 6km/s at depth of 1~2 km below seafloor, probably indicating uplift of deep-seated rocks. In this presentation we will show 3D seismic structure of this area.

  19. [Organization of care : specialized psychiatric clinic or general psychiatric clinic ? A debate between Louis Guérette and Jean-Pierre Rodriguez.].

    PubMed

    Robitaille, D

    1999-01-01

    The author reports on the opinions of doctors Louis Guérette and Jean-Pierre Rodriguez, both psychiatrists - one working at the Pavillon Notre-Dame of the Centre hospitalier universitaire de Montréal (CHUM) - the other at the Pavillon Albert-Prévost (PAP) of the Hôpital du Sacré-Coeur de Montréal, - on the place of specialized psychiatric clinics in the organization of care in psychiatry. Dr Guérette who practices general psychiatry thinks specialized clinics are not an appropriate mode of care delivery. Dr Rodriguez, answering to Dr Guérette's arguments, presents the organizational system of specialized clinics put in place at the PAP. The questions raised by the author and the psychiatrists' answers are reported. Finally, the author, a resident doctor in psychiatry, presents his own personal opinion on the issue.

  20. Advantages to Indigo mechanical thrombectomy for ALI: device and technique.

    PubMed

    Yamada, R; Adams, J; Guimaraes, M; Schönholz, C

    2015-06-01

    Catheter-directed thrombolysis (CDT) has been used as the first therapeutic option for acute limb ischemia (ALI) due to its less invasive nature; however, recent systematic review showed higher incidence of major complications related to lytic infusion, including hemorrhagic stroke. In this setting, aspiration thrombectomy with Indigo has the greatest advantage of not increasing systemic risk of bleeding. The Indigo™ system from Penumbra® (Alameda, CA, USA) promotes active thrombectomy using a vacuum pump that generates substantial suction, enabling aspiration of clots of varying sizes and lengths. The device has three components: aspiration catheter, separator and pump. There are 2 aspiration catheter sizes: CAT 3 and CAT 5. The separators are intended to mobilize the clot and clean the catheter lumen, and therefore restoring flow for continuous aspiration. The pump is small-sized equipment capable of applying near pure vacuum aspiration pressure of -29 mmHg. Aspiration thrombectomy with Indigo has two key advantages: it does not require the use of lytics, and it provides immediate flow reestablishment. Its use when thrombolysis is contraindicated or has failed is already well established and, in the future, it may likely become the first line endovascular option in patients with acute limb ischemia.

  1. The development of the hand-held dual-sensor ALIS

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Fujiwara, Jun; Takahashi, Kazunori

    2007-04-01

    Since 2002, we have developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. It makes possible to process the data afterwards, including migration. The migration processing drastically increases the quality of the image of the buried objects. The new system, we do not need any standard mark on the ground. Also, ALIS uses two different GPOR systems, including VNA (Vector Network Analyzer) based GPR and an Impulse GPR. VNA based GPR can provide better quality GPR images, although the impulse GPR is faster and light weight. ALIS evaluation tests were held in mine affected courtiers including Afghanistan, Croatia, Egypt and Cambodia. In the two-month evaluation test in Cambodia, ALIS worked without any problem. After some demonstrations and evaluation, we got many useful suggestions. Using these advises, we have modified the ALIS and it is now more easy to use. ALIS will be commercialized in 2007.

  2. Dynamic virtual AliEn Grid sites on Nimbus with CernVM

    NASA Astrophysics Data System (ADS)

    Harutyunyan, A.; Buncic, P.; Freeman, T.; Keahey, K.

    2010-04-01

    We describe the work on enabling one click deployment of Grid sites of AliEn Grid framework on the Nimbus 'science cloud' at the University of Chicago. The integration of computing resources of the cloud with the resource pool of AliEn Grid is achieved by leveraging two mechanisms: the Nimbus Context Broker developed at Argonne National Laboratory and the University of Chicago, and CernVM - a baseline virtual software appliance for LHC experiments developed at CERN. Two approaches of dynamic virtual AliEn Grid site deployment are presented.

  3. Hand-held dual-sensor ALIS and its evaluation tests

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Takahashi, Kazunori

    2008-04-01

    Since 2002, our research group at Tohoku University has developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. It makes possible to process the data afterwards, including migration. The migration processing drastically increases the quality of the image of the buried objects. ALIS evaluation test was conducted in Croatia in October 2007. Then after, we stared a half-year evaluation test of ALIS in QC test in Croatia in December 2007. This test will be conducted in various soil and environmental conditions in Croatia.

  4. Brown Country: Johnny Rodriguez

    ERIC Educational Resources Information Center

    Vargas, Deborah R.

    2007-01-01

    The year 1972 was part of a dynamic period of Chicano politics and cultural production in South Texas. A few years earlier, in the Crystal City Revolts, Tejanos had moved to gain control of city and school board positions, events that resulted in the creation of the Raza Unida Party in 1970. Nineteen seventy-two also marked the beginning of the…

  5. Brown Country: Johnny Rodriguez

    ERIC Educational Resources Information Center

    Vargas, Deborah R.

    2007-01-01

    The year 1972 was part of a dynamic period of Chicano politics and cultural production in South Texas. A few years earlier, in the Crystal City Revolts, Tejanos had moved to gain control of city and school board positions, events that resulted in the creation of the Raza Unida Party in 1970. Nineteen seventy-two also marked the beginning of the…

  6. Relocalization of nuclear ALY proteins to the cytoplasm by the tomato bushy stunt virus P19 pathogenicity protein.

    PubMed

    Uhrig, Joachim F; Canto, Tomas; Marshall, David; MacFarlane, Stuart A

    2004-08-01

    The P19 protein of tomato bushy stunt virus (TBSV) is a multifunctional pathogenicity determinant involved in suppression of posttranscriptional gene silencing, virus movement, and symptom induction. Here, we report that P19 interacts with the conserved RNA-binding domain of an as yet uncharacterized family of plant ALY proteins that, in animals, are involved in export of RNAs from the nucleus and transcriptional coactivation. We show that the four ALY proteins encoded by the Arabidopsis genome and two ALY proteins from Nicotiana benthamiana are localized to the nucleus. Moreover, and in contrast to animal ALY, all but one of the proteins are also in the nucleolus, with distinct subnuclear localizations. Infection of plants by TBSV or expression of P19 from Agrobacterium results in relocation of three of the six ALY proteins from the nucleus to the cytoplasm demonstrating specific targeting of the ALY proteins by P19. The differential effects on subcellular localization indicate that, in plants, the various ALY proteins may have different functions. Interaction with and relocalization of ALY is prevented by mutation of P19 at residues previously shown to be important for P19 function in plants. Down-regulation of expression of two N. benthamiana ALY genes by virus-induced gene silencing did not interfere with posttranscriptional gene silencing. Targeting of ALY proteins during TBSV infection may therefore be related to functions of P19 in addition to its silencing suppression activity.

  7. Aly/ REF, a factor for mRNA transport, activates RH gene promoter function.

    PubMed

    Suganuma, Hiroshi; Kumada, Maki; Omi, Toshinori; Gotoh, Takaya; Lkhagvasuren, Munkhtulga; Okuda, Hiroshi; Kamesaki, Toyomi; Kajii, Eiji; Iwamoto, Sadahiko

    2005-06-01

    The rhesus (Rh) blood group antigens are of considerable importance in transfusion medicine as well as in newborn or autoimmune hemolytic diseases due to their high antigenicity. We identified a major DNaseI hypersensitive site at the 5' flanking regions of both RHD and RHCE exon 1. A 34 bp fragment located at -191 to -158 from a translation start position, and containing the TCCCCTCCC sequence, was involved in enhancing promoter activity, which was assessed by luciferase reporter gene assay. A biotin-labelled 34 bp probe isolated an mRNA transporter protein, Aly/REF. The specific binding of Aly/REF to RH promoter in erythroid was confirmed by chromatin immunoprecipitation assay. The silencing of Aly/REF by siRNA reduced not only the RH promoter activity of the reporter gene but also transcription from the native genome. These facts provide second proof of Aly/REF as a transcription coactivator, initially identified as a coactivator for the TCRalpha enhancer function. Aly/REF might be a novel transcription cofactor for erythroid-specific genes.

  8. Hyperspectral Transformation from EO-1 ALI Imagery Using Pseudo-Hyperspectral Image Synthesis Algorithm

    NASA Astrophysics Data System (ADS)

    Tien Hoang, Nguyen; Koike, Katsuaki

    2016-06-01

    Hyperspectral remote sensing is more effective than multispectral remote sensing in many application fields because of having hundreds of observation bands with high spectral resolution. However, hyperspectral remote sensing resources are limited both in temporal and spatial coverage. Therefore, simulation of hyperspectral imagery from multispectral imagery with a small number of bands must be one of innovative topics. Based on this background, we have recently developed a method, Pseudo-Hyperspectral Image Synthesis Algorithm (PHISA), to transform Landsat imagery into hyperspectral imagery using the correlation of reflectance at the corresponding bands between Landsat and EO-1 Hyperion data. This study extends PHISA to simulate pseudo-hyperspectral imagery from EO-1 ALI imagery. The pseudo-hyperspectral imagery has the same number of bands as that of high-quality Hyperion bands and the same swath width as ALI scene. The hyperspectral reflectance data simulated from the ALI data show stronger correlation with the original Hyperion data than the one simulated from Landsat data. This high correlation originates from the concurrent observation by the ALI and Hyperion sensors that are on-board the same satellite. The accuracy of simulation results are verified by a statistical analysis and a surface mineral mapping. With a combination of the advantages of both ALI and Hyperion image types, the pseudo-hyperspectral imagery is proved to be useful for detailed identification of minerals for the areas outside the Hyperion coverage.

  9. Preliminary studies on the extraction of Glycospanonins in Tongkat Ali extract

    NASA Astrophysics Data System (ADS)

    Abirame, S.; Sivakumar, K.; Chua, L. S.; Sarmidi, M. R.

    2016-06-01

    Eurycoma longifolia, locally known as Tongkat Ali, is a famous medicinal plant in the family of Simaroubaceae and well known for its aphrodisiac properties from its water extract. The root of E. longifolia is used to extract wide range bioactive components of Tongkat Ali. Previous works standardised Tongkat Ali extracts by measuring the concentration of eurycomanone, a quassinoid marker chemical, within the overall extract. There is a newer Malaysian standard that specifies that Tongkat Ali can be standardised to glycosaponin, thus it is desired to determine how extraction parameters such as particle size, extraction temperature, and solvent type affects the glycosaponin content in the extract. The overall study is aimed to determine how the extraction parameters affect the glycosaponin amount in extract. This paper presents the preliminary work where in this study the effect of particle size on overall extract and glycosaponin quantification method development is presented. A reflux extraction method was used to extract Tongkat Ali with a particle size of 0.5 mm, 1.0 mm and 2.0 mm of raw material to study effect of particle size on overall extract. Water and methanol were the two types of solvent used for extraction to study the quantity of glycosaponin.

  10. AliView: a fast and lightweight alignment viewer and editor for large datasets.

    PubMed

    Larsson, Anders

    2014-11-15

    AliView is an alignment viewer and editor designed to meet the requirements of next-generation sequencing era phylogenetic datasets. AliView handles alignments of unlimited size in the formats most commonly used, i.e. FASTA, Phylip, Nexus, Clustal and MSF. The intuitive graphical interface makes it easy to inspect, sort, delete, merge and realign sequences as part of the manual filtering process of large datasets. AliView also works as an easy-to-use alignment editor for small as well as large datasets. AliView is released as open-source software under the GNU General Public License, version 3.0 (GPLv3), and is available at GitHub (www.github.com/AliView). The program is cross-platform and extensively tested on Linux, Mac OS X and Windows systems. Downloads and help are available at http://ormbunkar.se/aliview anders.larsson@ebc.uu.se Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

  11. ALIS (Auroral Large Imaging System) used for optical observations of the meteor impact process

    NASA Astrophysics Data System (ADS)

    Brändström, U.; Gustavsson, B.; Steen, A.; Pellinen-Wannberg, Asta

    2001-11-01

    This paper outlines a possibly new use of the Auroral Large Imaging System (ALIS) for studies of differential ablation phenomena in meteor trails. By simultaneous imaging from up to six stations, the altitude distribution of the meteor trails could be triangulated, while some stations simultaneously image the trails in for example the sodium (5893 Å) and calcium (4227 Å) lines. ALIS was primarily designed for auroral studies, but has also been used for studies of heater-induced airglow, polar stratospheric clouds as well as other phenomena. The system consits of six unmanned remote-controlled observation stations located in northern Sweden.

  12. Highly Pathogenic Avian Influenza Virus Nucleoprotein Interacts with TREX Complex Adaptor Protein Aly/REF

    PubMed Central

    Balasubramaniam, Vinod R. M. T.; Hong Wai, Tham; Ario Tejo, Bimo; Omar, Abdul Rahman; Syed Hassan, Sharifah

    2013-01-01

    We constructed a novel chicken (Gallus gallus) lung cDNA library fused inside yeast acting domain vector (pGADT7). Using yeast two-hybrid screening with highly pathogenic avian influenza (HPAI) nucleoprotein (NP) from the strain (A/chicken/Malaysia/5858/2004(H5N1)) as bait, and the Gallus gallus lung cDNA library as prey, a novel interaction between the Gallus gallus cellular RNA export adaptor protein Aly/REF and the viral NP was identified. This interaction was confirmed and validated with mammalian two hybrid studies and co-immunoprecipitation assay. Cellular localization studies using confocal microscopy showed that NP and Aly/REF co-localize primarily in the nucleus. Further investigations by mammalian two hybrid studies into the binding of NP of other subtypes of influenza virus such as the swine A/New Jersey/1976/H1N1 and pandemic A/Malaysia/854/2009(H1N1) to human Aly/REF, also showed that the NP of these viruses interacts with human Aly/REF. Our findings are also supported by docking studies which showed tight and favorable binding between H5N1 NP and human Aly/REF, using crystal structures from Protein Data Bank. siRNA knockdown of Aly/REF had little effect on the export of HPAI NP and other viral RNA as it showed no significant reduction in virus titer. However, UAP56, another component of the TREX complex, which recruits Aly/REF to mRNA was found to interact even better with H5N1 NP through molecular docking studies. Both these proteins also co-localizes in the nucleus at early infection similar to Aly/REF. Intriguingly, knockdown of UAP56 in A549 infected cells shows significant reduction in viral titer (close to 10 fold reduction). Conclusively, our study have opened new avenues for research of other cellular RNA export adaptors crucial in aiding viral RNA export such as the SRSF3, 9G8 and ASF/SF2 that may play role in influenza virus RNA nucleocytoplasmic transport. PMID:24073193

  13. Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF.

    PubMed

    Balasubramaniam, Vinod R M T; Hong Wai, Tham; Ario Tejo, Bimo; Omar, Abdul Rahman; Syed Hassan, Sharifah

    2013-01-01

    We constructed a novel chicken (Gallus gallus) lung cDNA library fused inside yeast acting domain vector (pGADT7). Using yeast two-hybrid screening with highly pathogenic avian influenza (HPAI) nucleoprotein (NP) from the strain (A/chicken/Malaysia/5858/2004(H5N1)) as bait, and the Gallus gallus lung cDNA library as prey, a novel interaction between the Gallus gallus cellular RNA export adaptor protein Aly/REF and the viral NP was identified. This interaction was confirmed and validated with mammalian two hybrid studies and co-immunoprecipitation assay. Cellular localization studies using confocal microscopy showed that NP and Aly/REF co-localize primarily in the nucleus. Further investigations by mammalian two hybrid studies into the binding of NP of other subtypes of influenza virus such as the swine A/New Jersey/1976/H1N1 and pandemic A/Malaysia/854/2009(H1N1) to human Aly/REF, also showed that the NP of these viruses interacts with human Aly/REF. Our findings are also supported by docking studies which showed tight and favorable binding between H5N1 NP and human Aly/REF, using crystal structures from Protein Data Bank. siRNA knockdown of Aly/REF had little effect on the export of HPAI NP and other viral RNA as it showed no significant reduction in virus titer. However, UAP56, another component of the TREX complex, which recruits Aly/REF to mRNA was found to interact even better with H5N1 NP through molecular docking studies. Both these proteins also co-localizes in the nucleus at early infection similar to Aly/REF. Intriguingly, knockdown of UAP56 in A549 infected cells shows significant reduction in viral titer (close to 10 fold reduction). Conclusively, our study have opened new avenues for research of other cellular RNA export adaptors crucial in aiding viral RNA export such as the SRSF3, 9G8 and ASF/SF2 that may play role in influenza virus RNA nucleocytoplasmic transport.

  14. 76 FR 62494 - Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Ibrahim `Awad Ibrahim al-Badri al-Samarrai, Also Known as Ibrahim Awwad Ibrahim al-Samarra'I, Also Known as Dr. Ibrahim Awwad...

  15. The evaluation test of hand-held dual-sensor ALIS in Croatia and Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Takahashi, Kazunori

    2007-04-01

    We are developing a new hand-held land mine detection dual-sensor (ALIS) which is equipped with a metal detector and a GPR. ALIS is equipped with a sensor tracking system, which can record the GPR and Metal detector signal with its location. It makes possible to process the data after the data was acquired, including migration. The migration processing drastically increases the quality of the images of the buried objects. Evaluation test of ALIS has been conducted in several test sites. In February 2006, a one-month evaluation test was conducted in Croatia, and in October- December 2006, a two-month evaluation test was conducted in Croatia. Since the dual-sensor is a new landmine detection sensor, and the conventional evaluation procedure developed for metal detectors cannot directly be applied for the dual sensor. In Croatia, the detection probability was comparable to that by a metal detector operated by local deminers. In addition, we showed that ALIS provides image of buried objects by GPR, which can be used for identification. Therefore, their performances were sufficiently high. Then the test was also conducted in Cambodia. The test was carried out by 2 local deminers independently, which allows studying the influence of different operators and increases the statistical value of the results.

  16. Deployment of dual-sensor ALIS for humanitarian demining in Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, M.; Takahashi, K.

    2013-06-01

    We are in the process of developing a high-resolution landmine scanning system "ALIS" which produces horizontal slices of the shallow subsurface for visualization of buried explosives and inert clutter. As many AP mines contain minimum amounts of metal, metal detectors need to be combined with a complimentary subsurface imaging sensor. Ground Penetrating Radar (GPR) is widely accepted for subsurface sensing in the fields of geology, archaeology and utility detection. The demining application requires real-time imaging results with centimetre resolution in a highly portable package. The key requirement for sharp images of the subsurface is the precise tracking of the geophysical sensor(s) during data collection. We should also notice that GPR system is a very wide band radar system, and equivalent to UWB radar, which has recently been developed for short-range high-accuracy radar. We are testing simplified but effective signal processing for imaging mines. We are currently testing a dual sensor ALIS which is a realtime sensor tracking system based on a CCD camera and image processing. In this paper we introduce the GPR systems which we have developed for detection of buried antipersonnel mines and small size explosives. ALIS has been deployed in Cambodia since 2009 and detected more than 70 mines in mine fields, and returned more than 13ha cleaned fields to local farmers. We also report the current status of ALIS in Cambodia.

  17. Cross calibration of the Landsat-7 ETM+ and EO-1 ALI sensor

    USGS Publications Warehouse

    Chander, G.; Meyer, D.J.; Helder, D.L.

    2004-01-01

    As part of the Earth Observer 1 (EO-1) Mission, the Advanced Land Imager (ALI) demonstrates a potential technological direction for Landsat Data Continuity Missions. To evaluate ALI's capabilities in this role, a cross-calibration methodology has been developed using image pairs from the Landsat-7 (L7) Enhanced Thematic Mapper Plus (ETM+) and EO-1 (ALI) to verify the radiometric calibration of ALI with respect to the well-calibrated L7 ETM+ sensor. Results have been obtained using two different approaches. The first approach involves calibration of nearly simultaneous surface observations based on image statistics from areas observed simultaneously by the two sensors. The second approach uses vicarious calibration techniques to compare the predicted top-of-atmosphere radiance derived from ground reference data collected during the overpass to the measured radiance obtained from the sensor. The results indicate that the relative sensor chip assemblies gains agree with the ETM+ visible and near-infrared bands to within 2% and the shortwave infrared bands to within 4%.

  18. Mechanism and early intervention research on ALI during emergence surgery of Stanford type-A AAD

    PubMed Central

    Cheng, Yi; Jin, Mu; Dong, Xiuhua; Sun, Lizhong; Liu, Jing; Wang, Rong; Yang, Yanwei; Lin, Peirong; Hou, Siyu; Ma, Yuehua; Wang, Yuefeng; Pan, Xudong; Lu, Jiakai; Cheng, Weiping

    2016-01-01

    Abstract Background: Stanford type-A acute aortic dissection (AAD) is a severe cardiovascular disease demonstrating the characteristics of acute onset and rapid development, with high morbidity and mortality. The available evidence shows that preoperative acute lung injury (ALI) induced by Stanford type-A AAD is a frequent and important cause for a number of untoward consequences. However, there is no study assessing the incidence of preoperative ALI and its independent determinants before Standford type-A AAD surgery in Chinese adult patients. Methods/design: This is a prospective, double-blind, signal-center clinical trial. We will recruit 130 adult patients undergoing Stanford type-A AAD surgery. The incidence of preoperative ALI will be evaluated. Perioperative clinical baselines and serum variables including coagulation, fibrinolysis, inflammatory, reactive oxygen species, and endothelial cell function will be assayed. The independent factors affecting the occurrence of preoperative ALI will be identified by multiple logistic regression analysis. Trial registration: ClinicalTrials.gov (https://register.clinicaltrials.gov/), Registration number NCT01894334. PMID:27759648

  19. Traumatic forequarter amputation associated acute lung injury (ALI): report of one case.

    PubMed

    Liang, K; Gan, X; Deng, Z

    2012-07-01

    One case of traumatic forequarter amputation associated acute lung injury (ALI) was presented. A discussion reviewing the treatment guidelines for this devastating injury, and pointing out the importance of supporting the lung and preventing the development of acute respiratory distress syndrome (ARDS) was included.

  20. Simultaneous quantitation of six major quassinoids in Tongkat Ali dietary supplements by liquid chromatography with tandem mass spectrometry.

    PubMed

    Han, Young Min; Jang, Moonhee; Kim, In Sook; Kim, Seung Hyun; Yoo, Hye Hyun

    2015-07-01

    Tongkat Ali (Eurycoma longifolia) is one of the most popular traditional herbs in Southeast Asia and generally consumed as forms of dietary supplements, tea, or drink additives for coffee or energy beverages. In this study, the liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of six major quassinoids of Tongkat Ali (eurycomanone, 13,21-dihydroeurycomanone, 13α(21)-epoxyeurycomanone, 14,15β-dihydroxyklaineanone, eurycomalactone, and longilactone) was developed and validated. Using the developed method, the content of the six quassinoids was measured in Tongkat Ali containing dietary supplement tablets or capsules, and the resulting data were used to confirm the presence of Tongkat Ali in those products. Among the six quassinoids, eurycomanone was the most abundant quassinoid in all samples tested. The developed method would be useful for the quality assessment of Tongkat Ali containing dietary supplements.

  1. Epithelial ciliated beating cells essential for ex vivo ALI culture growth.

    PubMed

    Gras, Delphine; Petit, Aurélie; Charriot, Jérémy; Knabe, Lucie; Alagha, Khuder; Gamez, Anne Sophie; Garulli, Céline; Bourdin, Arnaud; Chanez, Pascal; Molinari, Nicolas; Vachier, Isabelle

    2017-05-03

    Bronchial epithelium plays a key role in orchestrating innate and adaptive immunity. The fate of ex vivo airway epithelial cultures growing at the air liquid interface (ALI) derived from human endobronchial biopsies or brushings is not easy to predict. Calibrating and differentiating these cells is a long and expensive process requiring rigorous expertise. Pinpointing factors associated with ALI culture success would help researchers gain further insight into epithelial progenitor behavior. A successful ALI culture was defined as one in which a pseudostratified epithelium has formed after 28 days in the presence of all differentiated epithelial cell types. A 4-year prospective bi-center study was conducted with adult subjects enrolled in different approved research protocols. 463 consecutive endobronchial biopsies were obtained from normal healthy volunteers, healthy smokers, asthmatic patients and smokers with COPD. All demographic variables, the different fiber optic centers and culture operators, numbers of endo-bronchial biopsies and the presence of ciliated cells were carefully recorded. Univariate and multivariate models were developed. A stepwise procedure was used to select the final logistic regression model. ALI culture success was independently associated with the presence of living ciliated cells within the initial biopsy (OR = 2.18 [1.50-3.16], p < 0.001). This finding highlights the properties of the cells derived from the epithelium dedifferentiation process. The preferential selection of samples with ciliated beating cells would probably save time and money. It is still unknown whether successful ALI culture is related to indicators of general cell viability or a purported stem cell state specifically associated with ciliated beating cells.

  2. ASTER, ALI and Hyperion sensors data for lithological mapping and ore minerals exploration.

    PubMed

    Beiranvand Pour, Amin; Hashim, Mazlan

    2014-01-01

    This paper provides a review of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Advanced Land Imager (ALI), and Hyperion data and applications of the data as a tool for ore minerals exploration, lithological and structural mapping. Spectral information extraction from ASTER, ALI, and Hyperion data has great ability to assist geologists in all disciplines to map the distribution and detect the rock units exposed at the earth's surface. The near coincidence of Earth Observing System (EOS)/Terra and Earth Observing One (EO-1) platforms allows acquiring ASTER, ALI, and Hyperion imagery of the same ground areas, resulting accurate information for geological mapping applications especially in the reconnaissance stages of hydrothermal copper and gold exploration, chromite, magnetite, massive sulfide and uranium ore deposits, mineral components of soils and structural interpretation at both regional and district scales. Shortwave length infrared and thermal infrared bands of ASTER have sufficient spectral resolution to map fundamental absorptions of hydroxyl mineral groups and silica and carbonate minerals for regional mapping purposes. Ferric-iron bearing minerals can be discriminated using six unique wavelength bands of ALI spanning the visible and near infrared. Hyperion visible and near infrared bands (0.4 to 1.0 μm) and shortwave infrared bands (0.9 to 2.5 μm) allowed to produce image maps of iron oxide minerals, hydroxyl-bearing minerals, sulfates and carbonates in association with hydrothermal alteration assemblages, respectively. The techniques and achievements reviewed in the present paper can further introduce the efficacy of ASTER, ALI, and Hyperion data for future mineral and lithological mapping and exploration of the porphyry copper, epithermal gold, chromite, magnetite, massive sulfide and uranium ore deposits especially in arid and semi-arid territory.

  3. Nonempirical electron-correlation calculations on ALi/sub k/ and Ali/sub k+1//sup +/ clusters formed with elements from the second and third periods

    SciTech Connect

    Mebel', A.M.; Klimenko, N.M.; Charkin, O.P.

    1988-11-01

    Several basic sets have been used (from 3-21 G/sub A//asterisk/ to DZHD + P/sub A/) with electron correlation in the Meller-Plesset MP3 approximation in nonempirical calculations on ALi/sub k+1//sup +/ and ALi/sub K+1//sup +/ lithium clusters (CLi/sub 2/, CLi/sub 3//sup +/, NLi/sub 3/, NLi/sub 4//sup +/, OLi/sub 2/, OLi/sub 3//sup +/, etc.) formed with elements from the second and third periods in the lowest singlet states. A study has been made on the effects of the approximation on the results. Several reference systems are used to show that the SCF/3-21G/sub A//asterisk/ approximation describes the lithide geometry satisfactorily, while MP3/DZHD + P/sub A/ gives a satisfactory description of the affinity of Ali/sub k/ for Li/sup +/. These approximations have been taken as optimal for calculations on the other compounds. The Li/sup +/ affinities are highest for NLi/sub 3/ and PLi/sub 3/ (90 and 84 kcal correspondingly) and decrease as A varies along the subgroups from the second to the third and the lower sp periods, as well as when A varies in each period from the middle to the start or end. The affinities of the analogous compounds for Na/sup +/ are less by 5-10 kcal than those for Li/sup +/. The values are compared with the proton affinities for the related hydrides AK/sub k/.

  4. Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine.

    PubMed

    Li, Wenli; Pauluhn, Juergen

    2017-12-01

    Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and associated preventive or therapeutic treatment strategies. Cardiopulmonary function was examined in rats exposed by inhalation to the alveolar irritant phosgene or to the airway irritant chlorine during and following exposure. Terminal measurements focused on hematology, protein extravasation in bronchoalveolar lavage (BAL), and increased lung weight. Noninvasive diagnostic and prognostic endpoints in exhaled breath (carbon dioxide and nitric oxide) were used to detect the clinically occult stage of pulmonary edema. The first event observed in rats following high but sublethal acute exposure to phosgene was the stimulation of alveolar nociceptive vagal receptors. This afferent stimulation resulted in dramatic changes in cardiopulmonary functions, ventilation: perfusion imbalances, and progressive pulmonary edema and phospholipoproteinosis. Hematology revealed hemoconcentration to be an early marker of pulmonary edema and fibrin as a discriminating endpoint that was positive for the airway irritant chlorine and negative for the alveolar irritant phosgene. The application of each gas produced typical ALI/ARDS (acute lung injury/acute respiratory distress syndrome) characteristics. Phosgene-induced ALI showed evidence of persistent apnea periods, bradycardia, and shifts of vascular fluid from the peripheral to the pulmonary circulation. Carbon dioxide in expired gas was suggestive of increased ventilation dead space and appeared to be a harbinger of progressively developing lung edema. Treatment with the iNOS inhibitor aminoguanidine aerosol by inhalation reduced the severity of phosgene-induced ALI when applied at low dose-rates. Symptomatic treatment regimens were considered inferior to causal modes of treatment.

  5. Involvement of CD4⁺ Foxp3⁺ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice.

    PubMed

    Tiwananthagorn, Saruda; Iwabuchi, Kazuya; Ato, Manabu; Sakurai, Tatsuya; Kato, Hirotomo; Katakura, Ken

    2012-01-01

    Visceral leishmaniasis (VL) is a chronic and fatal disease in humans and dogs caused by the intracellular protozoan parasites, Leishmania donovani and L. infantum (L. chagasi). Relapse of disease is frequent in immunocompromised patients, in which the number of VL cases has been increasing recently. The present study is aimed to improve the understanding of mechanisms of L. donovani persistence in immunocompromised conditions using alymphoplastic aly/aly mice. Hepatic parasite burden, granuloma formation and induction of regulatory T cells were determined for up to 7 months after the intravenous inoculation with L. donovani promastigotes. While control aly/+ mice showed a peak of hepatic parasite growth at 4 weeks post infection (WPI) and resolved the infection by 8 WPI, aly/aly mice showed a similar peak in hepatic parasite burden but maintained persistent in the chronic phase of infection, which was associated with delayed and impaired granuloma maturation. Although hepatic CD4(+)Foxp3(+) but not CD8(+)Foxp3(+) T cells were first detected at 4 WPI in both strains of mice, the number of CD4(+)Foxp3(+) T cells was significantly increased in aly/aly mice from 8 WPI. Immunohistochemical analysis demonstrated the presence of Foxp3(+) T cells in L. donovani-induced hepatic granulomas and perivascular neo-lymphoid aggregates. Quantitative real-time PCR analysis of mature granulomas collected by laser microdissection revealed the correlation of Foxp3 and IL-10 mRNA level. Furthermore, treatment of infected aly/aly mice with anti-CD25 or anti-FR4 mAb resulted in significant reductions in both hepatic Foxp3(+) cells and parasite burden. Thus, we provide the first evidence that CD4(+)Foxp3(+) Tregs mediate L. donovani persistence in the liver during VL in immunodeficient murine model, a result that will help to establish new strategies of immunotherapy against this intracellular protozoan pathogen.

  6. Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.

    PubMed

    Girish, Sonal; Kumar, Suresh; Aminudin, Norhaniza

    2015-06-18

    In the local Malaysian context, herbal plants such as Eurycoma longifolia (Tongkat Ali), Orthosiphon stamineus (MisaiKucing), Ficus deltoidea (Mas Cotek), Zingiber officinale (Halia Bara) and Barringtonia racemosa (Putat) are known and widely used for its therapeutic properties. The first part of this study aims to screen for the anti-protozoal activity of these herbal plant extracts against Blastocystis sp. isolate subtype (ST) 3. Herbal extract with the highest efficacy was further fractionized into water and ethyl acetate fractions and tested against ST1, ST3 and ST5 Blastocystis sp. isolates. These isolates were also exposed to allopathic drugs, Metronidazole (MTZ), Tinidazole, Trimethoprim-sulfamethoxazole(TMP-SMX), Ketoconazole and Nitazoxanide for comparison purpose. Blastocystis sp. isolates from human-derived stool samples were exposed to herbal extracts and allopathic drugs at a concentration of 0.1 mg/ml and 1.0 mg/ml and were incubated at 37 °C. Growth profile studies were carried out. After 72 h of treatment, the viability of Blastocystis sp. as a result of the effects of the drugs and herbal extracts were assessed. Based on the screening process, amongst all the extracts, Tongkat Ali exhibited the highest anti-protozoal activity at 1.0 mg/ml. Between the water and ethyl acetate fractions of Tongkat Ali, the ethyl acetate fraction exhibited a slightly higher percentage of anti-protozoal activity at 1.0 mg/ml across subtypes, ST1 (94.9%), ST3 (95.1%) and ST5 (94.3%). When tested with allopathic drugs, at the same concentration, MTZ exhibited the highest anti-protozoal activity across subtypes, ST1 (95.8%), ST3 (93.4%) and ST5 (90.8%). This study is the first to describe the anti-protozoal properties of Tongkat Ali against Blastocystis sp. isolates. Ethyl acetate fraction of Tongkat Ali demonstrated the highest anti-protozoal activity against Blastocystis sp. isolates and showed a sizeable reduction in the cell count which was comparable with MTZ

  7. An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography.

    PubMed

    Yang, Chang-Tong; Chandrasekharan, Prashant; He, Tao; Poh, Zihan; Raju, Anandhkumar; Chuang, Kai-Hsiang; Robins, Edward G

    2014-01-01

    An intravascular MRI contrast agent Gd(DO3A-Lys), Gadolinium(III) (2,2',2″-(10-(3-(5-benzamido-6-methoxy-6-oxohexylamino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate), has been studied for tumor angiography based on its high relaxivity and long blood half-life. The preparation procedures of the contrast agent have been modified in order to achieve higher yield and improve the synthetic reproducibility. High relaxivity of Gd(DO3A-Lys) has been confirmed by measurements at 3 T, 7 T and 9.4 T magnetic fields. The relaxivity-dependent albumin binding study indicated that Gd(DO3A-Lys) partially bound to albumin protein. In vitro cell viability in HK2 cell indicated low cytotoxicity of Gd(DO3A-Lys) up to 1.2 mM [Gd] concentration. In vivo toxicity studies demonstrated no toxicity of Gd(DO3A-Lys) on kidney tissues up to 0.2 mM [Gd]. While the toxicity on liver tissue was not observed at low dosage (1.0 mM [Gd]), Gd(DO3A-Lys) cause certain damage on hepatic tissue at high dosage (2.0 mM [Gd]). The DO3A-Lys has been labeled with (68)Ga radioisotope for biodistribution studies. (68)Ga(DO3A-Lys) has high uptake in both HT1080 and U87MG xenograft tumors, and has high accumulation in blood. Contrast-enhanced MR angiography (CE-MRA) in mice bearing U87MG xenograft tumor demonstrated that Gd(DO3A-Lys) could enhance vascular microenvironment around the tumor, and displays promising characteristics of an MRI contrast agent for tumor angiography.

  8. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance.

    PubMed

    Bhat, Rajeev; Karim, A A

    2010-10-01

    Eurycoma longifolia Jack is an herbal medicinal plant of South-East Asian origin, popularly recognized as 'Tongkat Ali.' The plant parts have been traditionally used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial and anti-pyretic activities, which have also been proved scientifically. The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and pasakbumin-B) among which the alkaloids and quassinoids form a major portion. Even though toxicity and safety evaluation studies have been pursued, still a major gap exists in providing scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumer's safety. The present review aims at reviewing the research works undertaken till date, on this plant in order to provide sufficient baseline information for future works and for commercial exploitation. Copyright © 2010 Elsevier B.V. All rights reserved.

  9. Stress field during early magmatism in the Ali Sabieh Dome, Djibouti, SE Afar rift

    NASA Astrophysics Data System (ADS)

    Sue, Christian; Le Gall, Bernard; Daoud, Ahmed Mohamed

    2014-09-01

    The so-called Ali Sabieh range, SE Afar rift, exhibits an atypical antiform structure occurring in the overall extensional tectonic context of the Afar triple junction. We dynamically analyzed the brittle deformation of this specific structural high using four different methods in order to better constrain the tectonic evolution of this key-area in the Afar depression. Paleostress inversions appear highly consistent using the four methods, which a posteriori validates this approach. Computed paleostress fields document two major signals: an early E-W extensional field, and a later transcurrent field, kinematically consistent with the previous one. The Ali Sabieh range may have evolved continuously during Oligo-Miocene times from large-scale extensional to transcurrent tectonism, as the result of probable local stress permutation between σ1 and σ2 stress axes.

  10. ALIS: a multistation imaging facility with possibilities for future VI applications

    NASA Astrophysics Data System (ADS)

    Brandstrom, Urban; Steen, Ake; Rydesater, Peter; Gustavsson, Bjorn; Aso, T.

    1999-03-01

    ALIS (Auroral Large Imaging System) is an imaging facility in Northern Sweden. The system consists of six unmanned, remote controlled stations. Each station has a high performance CCD imager, and some stations also have other scientific instrumentation (e.g. pulsation magnetometers). ALIS is capable of producing large amounts of data in a short time. For that reason, novel (AI/VI) techniques for data analysis, are of high priority in order to be able to handle the large data sets. In this paper we will try to describe the current implementation and address the questions of how to interface AI/VI applications to an existing multi station research facility, in terms of real- time experiment control, selective imaging, real-time data analysis, etc.

  11. Plant proteins, minerals and trace elements of Eurycoma longifolia (Tongkat Ali).

    PubMed

    Chua, Lee Suan; Abdul-Rahman, Nurulaini; Rosidi, Bustanur; Lee, Chew Tin

    2013-03-01

    A water extraction method has been used to extract plant proteins from the roots of Eurycoma longifolia harvested from Perak and Pahang, Malaysia. On the basis of the spectroscopic Bradford assay, Tongkat Ali Perak and Pahang contained 0.3868 and 0.9573 mg mL(-1) of crude protein, respectively. The crude proteins were separated by one dimensional 15% sodium dodecyl sulphate polyacrylamide gel electrophoresis into two (49.8 and 5.5 kD) and four (49.8, 24.7, 21.1 and 5.5 kD) protein spots for Tongkat Ali Perak and Pahang, respectively. Isoleucine was present in the highest concentration significantly. Both plant samples showed differences in the mineral and trace element profiles, but the minerals calcium, magnesium and potassium were present in the highest concentration. The highly concerned toxic metals such as arsenic and lead were not detected.

  12. Comparison of EO1 Landsat-7 ETM+ and EO-1 ALI images over Rochester, New York

    NASA Astrophysics Data System (ADS)

    Pedelty, Jeffrey A.; Morisette, Jeffrey T.; Smith, James A.

    2002-08-01

    We present a comparison of images from the ETM+ sensor on Landsat-7 and the ALI instrument on EO-1 over a test site in Rochester, NY. The site contains a variety of features, ranging from water of varying depths, deciduous/coniferous forest, grass fields, to urban areas. The nearly coincident cloud-free images were collected just one minute apart on 25 August, 2001. We atmospherically corrected each image with the 6S atmosphere model, using aerosol optical thickness and water vapor column density measured by a Cimel sun photometer within the Aerosol Robotic Network (Aeronet), along with ozone density derived from NCEP data. We present three-color composites from each instrument that show excellent qualitative agreement. We present ETM+ and ALI reflectance spectra for water, grass, and urban targets. We make a more detailed comparison for our forest site, where we use measured geometric and optical properties as input to the SAIL canopy reflectance model, which we compare to the ETM+, ALI, and EO-1 Hyperion reflectance spectra.

  13. JAliEn - A new interface between the AliEn jobs and the central services

    NASA Astrophysics Data System (ADS)

    Grigoras, A. G.; Grigoras, C.; Pedreira, M. M.; Saiz, P.; Schreiner, S.

    2014-06-01

    Since the ALICE experiment began data taking in early 2010, the amount of end user jobs on the AliEn Grid has increased significantly. Presently 1/3 of the 40K CPU cores available to ALICE are occupied by jobs submitted by about 400 distinct users, individually or in organized analysis trains. The overall stability of the AliEn middleware has been excellent throughout the 3 years of running, but the massive amount of end-user analysis and its specific requirements and load has revealed few components which can be improved. One of them is the interface between users and central AliEn services (catalogue, job submission system) which we are currently re-implementing in Java. The interface provides persistent connection with enhanced data and job submission authenticity. In this paper we will describe the architecture of the new interface, the ROOT binding which enables the use of a single interface in addition to the standard UNIX-like access shell and the new security-related features.

  14. Securing the AliEn File Catalogue - Enforcing authorization with accountable file operations

    NASA Astrophysics Data System (ADS)

    Schreiner, Steffen; Bagnasco, Stefano; Sankar Banerjee, Subho; Betev, Latchezar; Carminati, Federico; Vladimirovna Datskova, Olga; Furano, Fabrizio; Grigoras, Alina; Grigoras, Costin; Mendez Lorenzo, Patricia; Peters, Andreas Joachim; Saiz, Pablo; Zhu, Jianlin

    2011-12-01

    The AliEn Grid Services, as operated by the ALICE Collaboration in its global physics analysis grid framework, is based on a central File Catalogue together with a distributed set of storage systems and the possibility to register links to external data resources. This paper describes several identified vulnerabilities in the AliEn File Catalogue access protocol regarding fraud and unauthorized file alteration and presents a more secure and revised design: a new mechanism, called LFN Booking Table, is introduced in order to keep track of access authorization in the transient state of files entering or leaving the File Catalogue. Due to a simplification of the original Access Envelope mechanism for xrootd-protocol-based storage systems, fundamental computational improvements of the mechanism were achieved as well as an up to 50% reduction of the credential's size. By extending the access protocol with signed status messages from the underlying storage system, the File Catalogue receives trusted information about a file's size and checksum and the protocol is no longer dependent on client trust. Altogether, the revised design complies with atomic and consistent transactions and allows for accountable, authentic, and traceable file operations. This paper describes these changes as part and beyond the development of AliEn version 2.19.

  15. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS

    PubMed Central

    Rajasekaran, Surender; Sanfilippo, Dominic; Shoemaker, Allen; Curtis, Scott; Zuiderveen, Sandra; Ndika, Akunne; Stoiko, Michael; Hassan, Nabil

    2012-01-01

    Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children's Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4 ± 7.5 to 116.5 ± 8.8 in transfused but increased from 148.0 ± 8.0 to 190.4 ± 17.8 (P < 0.001) in control. OI increased in the transfused from 11.7 ± 0.9 to 18.7 ± 1.6 but not in control. Ventilator days in the transfused were 15.6 ± 1.7 versus 9.5 ± 0.6 days in control (P < 0.001). There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6–5.6 Fisher exact P < 0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs. PMID:22957223

  16. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS.

    PubMed

    Rajasekaran, Surender; Sanfilippo, Dominic; Shoemaker, Allen; Curtis, Scott; Zuiderveen, Sandra; Ndika, Akunne; Stoiko, Michael; Hassan, Nabil

    2012-01-01

    Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children's Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4 ± 7.5 to 116.5 ± 8.8 in transfused but increased from 148.0 ± 8.0 to 190.4 ± 17.8 (P < 0.001) in control. OI increased in the transfused from 11.7 ± 0.9 to 18.7 ± 1.6 but not in control. Ventilator days in the transfused were 15.6 ± 1.7 versus 9.5 ± 0.6 days in control (P < 0.001). There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6-5.6 Fisher exact P < 0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs.

  17. Summary of Current Radiometric Calibration Coefficients for Landsat MSS, TM, ETM+, and EO-1 ALI Sensors

    NASA Technical Reports Server (NTRS)

    Chander, Gyanesh; Markham, Brian L.; Helder, Dennis L.

    2009-01-01

    This paper provides a summary of the current equations and rescaling factors for converting calibrated Digital Numbers (DNs) to absolute units of at-sensor spectral radiance, Top-Of- Atmosphere (TOA) reflectance, and at-sensor brightness temperature. It tabulates the necessary constants for the Multispectral Scanner (MSS), Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+), and Advanced Land Imager (ALI) sensors. These conversions provide a basis for standardized comparison of data in a single scene or between images acquired on different dates or by different sensors. This paper forms a needed guide for Landsat data users who now have access to the entire Landsat archive at no cost.

  18. The Persian legend of ophthalmology: Ali Asghar Khodadoust and his everlasting lines.

    PubMed

    Sajjadi, Sepideh; Fesharaki, Hamid; Abtahi, Zahra-Alsadat; Murray, Richard T; Fereidan-Esfahani, Mahboobeh; Mazloumi, Mehdi; Abtahi, Seyed-Hossein

    2013-06-01

    This is a brief celebratory overview of the fruitful life and scientific endeavors of Professor Ali Asghar Khodadoust (b.1935), a world renowned ophthalmologist, Persian icon of modern ophthalmology and an international pioneer of eye research. The global reputation of Dr. Khodadoust is rooted in his extensive studies on corneal diseases and transplantation biology. As a result of his truly deserved world renown, several famous American ophthalmologists have recognized him as the world's best corneal graft surgeon. Due to his exceptionally impressive achievements in this field, a clinical finding has been named in his honor, the "Khodadoust rejection line", a sign indicative of a chronic focal transplant reaction.

  19. Summary of current radiometric calibration coefficients for Landsat MSS, TM, ETM+, and EO-1 ALI sensors

    USGS Publications Warehouse

    Chander, G.; Markham, B.L.; Helder, D.L.

    2009-01-01

    This paper provides a summary of the current equations and rescaling factors for converting calibrated Digital Numbers (DNs) to absolute units of at-sensor spectral radiance, Top-Of-Atmosphere (TOA) reflectance, and at-sensor brightness temperature. It tabulates the necessary constants for the Multispectral Scanner (MSS), Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+), and Advanced Land Imager (ALI) sensors. These conversions provide a basis for standardized comparison of data in a single scene or between images acquired on different dates or by different sensors. This paper forms a needed guide for Landsat data users who now have access to the entire Landsat archive at no cost.

  20. Magma-driven antiform structures in the Afar rift: The Ali Sabieh range, Djibouti

    NASA Astrophysics Data System (ADS)

    Le Gall, Bernard; Daoud, Mohamed Ahmed; Maury, René C.; Rolet, Joël; Guillou, Hervé; Sue, Christian

    2010-06-01

    The Ali Sabieh Range, SE Afar, is an antiform involving Mesozoic sedimentary rocks and synrift volcanics. Previous studies have postulated a tectonic origin for this structure, in either a contractional or extensional regime. New stratigraphic, mapping and structural data demonstrate that large-scale doming took place at an early stage of rifting, in response to a mafic laccolithic intrusion dated between 28 and 20 Ma from new K-Ar age determinations. Our 'laccolith' model is chiefly supported by: (i) the geometry of the intrusion roof, (ii) the recognition of roof pendants in its axial part, and (iii) the mapping relationships between the intrusion, the associated dyke-sill network, and the upper volcanic/volcaniclastic sequences. The laccolith is assumed to have inflated with time, and to have upwardly bent its sedimentary roof rocks. From the architecture of the ˜1 km-thick Mesozoic overburden sequences, ca. 2 km of roof lifting are assumed to have occurred, probably in association with reactivated transverse discontinuities. Computed paleostress tensors indicate that the minimum principal stress axis is consistently horizontal and oriented E-W, with a dominance of extensional versus strike-slip regimes. The Ali Sabieh laccolith is the first regional-scale magma-driven antiform structure reported so far in the Afro-Arabian rift system.

  1. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

    PubMed Central

    2013-01-01

    Background Eurycoma longifolia is a medicinal plant commonly called tongkat ali (TA) and “Malaysian ginseng.” TA roots are a traditional “anti-aging” remedy and modern supplements are intended to improve libido, energy, sports performance and weight loss. Previous studies have shown properly-standardized TA to stimulate release of free testosterone, improve sex drive, reduce fatigue, and improve well-being. Methods We assessed stress hormones and mood state in 63 subjects (32 men and 31 women) screened for moderate stress and supplemented with a standardized hot-water extract of TA root (TA) or Placebo (PL) for 4 weeks. Analysis of variance (ANOVA) with significance set at p < 0.05 was used to determine differences between groups. Results Significant improvements were found in the TA group for Tension (−11%), Anger (−12%), and Confusion (−15%). Stress hormone profile (salivary cortisol and testosterone) was significantly improved by TA supplementation, with reduced cortisol exposure (−16%) and increased testosterone status (+37%). Conclusion These results indicate that daily supplementation with tongkat ali root extract improves stress hormone profile and certain mood state parameters, suggesting that this “ancient” remedy may be an effective approach to shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training. PMID:23705671

  2. Simulation of EO-1 Hyperion Data from ALI Multispectral Data Based on the Spectral Reconstruction Approach.

    PubMed

    Liu, Bo; Zhang, Lifu; Zhang, Xia; Zhang, Bing; Tong, Qingxi

    2009-01-01

    Data simulation is widely used in remote sensing to produce imagery for a new sensor in the design stage, for scale issues of some special applications, or for testing of novel algorithms. Hyperspectral data could provide more abundant information than traditional multispectral data and thus greatly extend the range of remote sensing applications. Unfortunately, hyperspectral data are much more difficult and expensive to acquire and were not available prior to the development of operational hyperspectral instruments, while large amounts of accumulated multispectral data have been collected around the world over the past several decades. Therefore, it is reasonable to examine means of using these multispectral data to simulate or construct hyperspectral data, especially in situations where hyperspectral data are necessary but hard to acquire. Here, a method based on spectral reconstruction is proposed to simulate hyperspectral data (Hyperion data) from multispectral Advanced Land Imager data (ALI data). This method involves extraction of the inherent information of source data and reassignment to newly simulated data. A total of 106 bands of Hyperion data were simulated from ALI data covering the same area. To evaluate this method, we compare the simulated and original Hyperion data by visual interpretation, statistical comparison, and classification. The results generally showed good performance of this method and indicated that most bands were well simulated, and the information both preserved and presented well. This makes it possible to simulate hyperspectral data from multispectral data for testing the performance of algorithms, extend the use of multispectral data and help the design of a virtual sensor.

  3. STS-45 Earth observation of the Persian Gulf and the island of Abu Ali

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-45 Earth observation taken aboard Atlantis, Orbiter Vehicle (OV) 104, is of the northern reaches of the Persian Gulf with the sunglint pattern centered on the Saudi Arabian island of Abu Ali. Bright features along the coast are thought to be deposits of oil, released from a terminal offshore of Kuwait during the recent Persian Gulf War. Further up the coast, in Kuwait, the black, oil-soaked desert surrounding the site of the oil well fires is clearly visible. View was taken from an altitude of 160 nautical miles with OV-104 located at 28 degrees north and 52.8 degrees east. During the STS-45 mission, an international survey team focused on oil contamination of the shallow-water habitants in the area north of Abu Ali Island. Crewmembers contacted the NOAA survey vessel, the R/V Mt. Mitchell, several times and photographed water color and sunglint within the study area and throughout the entire Persian Gulf. These photographic data are expected to aid the Persian Gulf researchers in

  4. STS-45 Earth observation of the Persian Gulf and the island of Abu Ali

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-45 Earth observation taken aboard Atlantis, Orbiter Vehicle (OV) 104, is of the northern reaches of the Persian Gulf with the sunglint pattern centered on the Saudi Arabian island of Abu Ali. Bright features along the coast are thought to be deposits of oil, released from a terminal offshore of Kuwait during the recent Persian Gulf War. Further up the coast, in Kuwait, the black, oil-soaked desert surrounding the site of the oil well fires is clearly visible. View was taken from an altitude of 160 nautical miles with OV-104 located at 28 degrees north and 52.8 degrees east. During the STS-45 mission, an international survey team focused on oil contamination of the shallow-water habitants in the area north of Abu Ali Island. Crewmembers contacted the NOAA survey vessel, the R/V Mt. Mitchell, several times and photographed water color and sunglint within the study area and throughout the entire Persian Gulf. These photographic data are expected to aid the Persian Gulf researchers in

  5. Technicians Ray Smith and Raphael Rodriguez remove one of the Extravehicular Mobility Units from the Space Shuttle Discovery after its landing at NASA Dryden

    NASA Image and Video Library

    2005-08-12

    Flight Crew Systems Technicians Ray Smith and Raphael Rodriguez remove one of the Extravehicular Mobility Units, or EMUs, from the Space Shuttle Discovery after it's successful landing at NASA's Dryden Flight Research Center. The Space Shuttles receive post-flight servicing in the Mate-Demate Device (MDD) following landings at NASA's Dryden Flight Research Center, Edwards, California. The gantry-like MDD structure is used for servicing the shuttle orbiters in preparation for their ferry flight back to the Kennedy Space Center in Florida, including mounting the shuttle atop NASA's modified Boeing 747 Shuttle Carrier Aircraft. Space Shuttle Discovery landed safely at NASA's Dryden Flight Research Center at Edwards Air Force Base in California at 5:11:22 a.m. PDT, August 9, 2005, following the very successful 14-day STS-114 return to flight mission. During their two weeks in space, Commander Eileen Collins and her six crewmates tested out new safety procedures and delivered supplies and equipment the International Space Station. Discovery spent two weeks in space, where the crew demonstrated new methods to inspect and repair the Shuttle in orbit. The crew also delivered supplies, outfitted and performed maintenance on the International Space Station. A number of these tasks were conducted during three spacewalks. In an unprecedented event, spacewalkers were called upon to remove protruding gap fillers from the heat shield on Discovery's underbelly. In other spacewalk activities, astronauts installed an external platform onto the Station's Quest Airlock and replaced one of the orbital outpost's Control Moment Gyroscopes. Inside the Station, the STS-114 crew conducted joint operations with the Expedition 11 crew. They unloaded fresh supplies from the Shuttle and the Raffaello Multi-Purpose Logistics Module. Before Discovery undocked, the crews filled Raffeallo with unneeded items and returned to Shuttle payload bay. Discovery launched on July 26 and spent almost 14

  6. Divergence of the gene aly in experimentally evolved cytoraces, the members of the nasuta-albomicans complex of Drosophila.

    PubMed

    Radhika, P N; Ramachandra, N B

    2014-08-01

    We generated cytoraces by crossing the chromosomal races (Drosophila nasuta nasuta and Drosophila nasuta albomicans) of the nasuta subgroup of Drosophila and maintained the offspring over many generations through sibling mating. These cytoraces, along with their parents, are members of the nasuta-albomicans complex of Drosophila. The gene always early (aly) is one of the rapidly evolving genes in the genus Drosophila and plays a central role in regulating meiosis. Here we examined the rate of molecular evolution of aly in cytoraces of Drosophila and demonstrated that the rate of substitutions amongst cytoraces is around eight times greater than their parents and even amongst species of subgenera. Thus, the presence of positive selection in the laboratory-derived cytoraces based on the analysis of the synonymous and nonsynonymous substitution rates of aly suggests the rapid evolution in cytoraces.

  7. HfxAlyO ternary dielectrics for InGaAs based metal-oxide-semiconductor capacitors

    NASA Astrophysics Data System (ADS)

    Krylov, Igor; Ritter, Dan; Eizenberg, Moshe

    2017-07-01

    The electrical properties of HfxAlyO compound dielectric films and the HfxAlyO/InGaAs interface are reported for various dielectric film compositions. Despite the same trimethylaluminum (TMA) pre-deposition treatment, dispersion in accumulation and capacitance-voltage (C-V) hysteresis increased with hafnium content. Different kinds of border traps were identified as being responsible for the phenomena. After anneal, the density of states in the HfxAlyO/InGaAs interface varied quite weakly with dielectric film composition. The optimal composition for obtaining high inversion charge density in metal oxide semiconductor gate stacks is determined by a tradeoff between leakage and dielectric constant, with the optimum atomic cation ratio ([Hf]/[Al]) of ˜1.

  8. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.

    PubMed

    Domínguez-Sánchez, María S; Sáez, Carmen; Japón, Miguel A; Aguilera, Andrés; Luna, Rosa

    2011-02-17

    One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples. The mRNA levels were measured by quantitative real-time PCR and hybridization of a tumor tissue cDNA array; and the protein levels and distribution by immunostaining of a custom tissue array containing a set of paraffin-embedded samples of different tumor and normal tissues followed by statistical analysis. We show that the expression of two mRNP factors, THOC1 and ALY are altered in several tumor tissues. THOC1 mRNA and protein levels are up-regulated in ovarian and lung tumors and down-regulated in those of testis and skin, whereas ALY is altered in a wide variety of tumors. In contrast to THOC1, ALY protein is highly detected in normal proliferative cells, but poorly in high-grade cancers. These results suggest a differential connection between tumorogenesis and the expression levels of human THO and ALY. This study opens the possibility of defining mRNP biogenesis factors as putative players in cell proliferation that could contribute to tumor development.

  9. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

    PubMed Central

    2011-01-01

    Background One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples. Methods The mRNA levels were measured by quantitative real-time PCR and hybridization of a tumor tissue cDNA array; and the protein levels and distribution by immunostaining of a custom tissue array containing a set of paraffin-embedded samples of different tumor and normal tissues followed by statistical analysis. Results We show that the expression of two mRNP factors, THOC1 and ALY are altered in several tumor tissues. THOC1 mRNA and protein levels are up-regulated in ovarian and lung tumors and down-regulated in those of testis and skin, whereas ALY is altered in a wide variety of tumors. In contrast to THOC1, ALY protein is highly detected in normal proliferative cells, but poorly in high-grade cancers. Conclusions These results suggest a differential connection between tumorogenesis and the expression levels of human THO and ALY. This study opens the possibility of defining mRNP biogenesis factors as putative players in cell proliferation that could contribute to tumor development. PMID:21329510

  10. Land cover mapping with emphasis to burnt area delineation using co-orbital ALI and Landsat TM imagery

    NASA Astrophysics Data System (ADS)

    Petropoulos, George P.; Kontoes, Charalambos C.; Keramitsoglou, Iphigenia

    2012-08-01

    In this study, the potential of EO-1 Advanced Land Imager (ALI) radiometer for land cover and especially burnt area mapping from a single image analysis is investigated. Co-orbital imagery from the Landsat Thematic Mapper (TM) was also utilised for comparison purposes. Both images were acquired shortly after the suppression of a fire occurred during the summer of 2009 North-East of Athens, the capital of Greece. The Maximum Likelihood (ML), Artificial Neural Networks (ANNs) and Support Vector Machines (SVMs) classifiers were parameterised and subsequently applied to the acquired satellite datasets. Evaluation of the land use/cover mapping accuracy was based on the error matrix statistics. Also, the McNemar test was used to evaluate the statistical significance of the differences between the approaches tested. Derived burnt area estimates were validated against the operationally deployed Services and Applications For Emergency Response (SAFER) Burnt Scar Mapping service. All classifiers applied to either ALI or TM imagery proved flexible enough to map land cover and also to extract the burnt area from other land surface types. The highest total classification accuracy and burnt area detection capability was returned from the application of SVMs to ALI data. This was due to the SVMs ability to identify an optimal separating hyperplane for best classes' separation that was able to better utilise ALI's advanced technological characteristics in comparison to those of TM sensor. This study is to our knowledge the first of its kind, effectively demonstrating the benefits of the combined application of SVMs to ALI data further implying that ALI technology may prove highly valuable in mapping burnt areas and land use/cover if it is incorporated into the development of Landsat 8 mission, planned to be launched in the coming years.

  11. First results of auroral tomography from ALIS-Japan multi-station observations in March, 1995

    NASA Astrophysics Data System (ADS)

    Aso, T.; Ejiri, M.; Urashima, A.; Miyaoka, H.; Steen, Å.; Brändström, U.; Gustavsson, B.

    1998-01-01

    Auroral tomography observations have been carried out in March, 1995, as a joint international campaign between Sweden and Japan. Three unmanned Swedish ALIS stations (Kiruna, Merasjärvi, Tjautjas) and two Japanese JICCD sites (Abisko, Nikkaluokta), geographically separated by about 50 km at higher latitudes, were operated to capture multi-station monochromatic tomography images at 557.7 nm wavelength using CCD cameras. All cameras were pointing to one of the predetermined directions to secure a common field of view. Several images of auroral arcs, mostly for the core region right above Kiruna, have synchronously been taken by the multi-station imaging system. Tomographic inversion analysis for four-point images was carried out using the algebraic reconstruction technique. Reconstructions of a curved arc and of a double arc system suggest promising application of this technique to the retrieval of three-dimensional auroral luminosity.

  12. FAMoS - an information service on the usage of data files in AliEn

    NASA Astrophysics Data System (ADS)

    Abramyan, A.; Betev, L.; Buncic, P.; Grigoras, C.; Grigoryan, A.; Manukyan, N.; Pedreira, M. M.; Saiz, P.

    2015-05-01

    The File Access Monitoring Service (FAMoS) leverages the information stored in the central AliEn file catalogue, which describes every file in a Unix-like directory structure, as well as metadata on file location and its replicas. In addition, it uses the access information provided by a set of API servers, used by all Grid clients to access the catalogue. The main functions of FAMoS are to sort the file accesses by logical groups, access time, user and storage element. The collected data identifies rarely used groups of files, as well as those with high popularity over different time periods. This information can be further used to optimize file distribution and replication factors, thus increasing the data processing efficiency. The paper describes the FAMoS structure and user interface and presents the results obtained in one year of service operation.

  13. Multi-instrument characterization of optical turbulence at the Ali observatory

    NASA Astrophysics Data System (ADS)

    Liu, L.-Y.; Yao, Y.-Q.; Vernin, J.; Wang, H.-S.; Yin, J.; Qian, X.

    2015-04-01

    In order to characterize the atmospheric optical turbulence at Ali observatory, we have deployed multi-instruments, which are able to continuously monitor the optical turbulence for site evaluation. These instruments include the DIMM, MASS, Single Star SCIDAR and Polaris seeing monitor, and we also plan to install SNODAR and Micro-thermal sensors for the turbulence on surface layer by the end of this year. This configuration allows us to collect a substantial database and make cross-comparison of the results. We have successfully obtained the profiles of optical turbulence and wind speed with Single Star SCIDAR, as well as the key parameters for adaptive optics application, such as seeing, coherence time, and isoplanatic angle. The DIMM seeing measurements are also carried out simultaneously. The median seeing measured by the DIMM and SSS in 2013 is 0.69 and 0.79 arcsec, respectively.

  14. Occurrence and genesis of Quaternary microbialitic tufa at Hammam Al Ali, Oman

    NASA Astrophysics Data System (ADS)

    Khalaf, Fikry I.

    2017-05-01

    Remnants of late Quaternary microbialitic tufa occurs within a shallow depression in the Hammam Al Ali hot spring area, which is located approximately 14.5 km to the southwest of Muscat, Oman. The tufa precipitated from hot spring water supersaturated with respect to calcium carbonate and is mostly of a porous phytogenic type, with occasional detrital and stromatolitic types. Microscopic and nanoscopic examination revealed that the tufa deposits developed through two successive processes of calcite precipitation, biotic and abiotic, preceded by limited precipitation of unstable aragonite. It is suggested that biologically mediated precipitation results in the construction of incomplete skeletal calcite crystals. The latter provide a base for classical physiochemical precipitation and, eventually, the development of complete sparry calcite crystals. The initiation of dendritic calcite crystals in the stromatolitic tufa as incomplete biogenic skeletal crystals and their characteristic growth pattern indicates that the tufa represents a clear example of hot spring calcitic microbialite.

  15. Ali Observatory in Tibet: a unique northern site for future CMB ground-based observations

    NASA Astrophysics Data System (ADS)

    Su, Meng

    2015-08-01

    Ground-based CMB observations have been performed at the South Pole and the Atacama desert in Chile. However, a significant fraction of the sky can not be observed from just these two sites. For a full sky coverage from the ground in the future, a northern site for CMB observation, in particular CMB polarization, is required. Besides the long-thought site in Greenland, the high altitude Tibet plateau provides another opportunity. I will describe the Ali Observatory in Tibet, located at N32°19', E80°01', as a potential site for ground-based CMB observations. The new site is located on almost 5100m mountain, near Gar town, where is an excellent site for both infrared and submillimeter observations. Study with the long-term database of ground weather stations and archival satellite data has been performed. The site has enough relative height on the plateau and is accessible by car. The Shiquanhe town is 40 mins away by driving, and a recently opened airport with 40 mins driving, the site also has road excess, electricity, and optical fiber with fast internet. Preliminary measurement of the Precipitable Water Vapor is ~one quarter less than 0.5mm per year and the long term monitoring is under development. In addition, surrounding higher sites are also available and could be further developed if necessary. Ali provides unique northern sky coverage and together with the South Pole and the Atacama desert, future CMB observations will be able to cover the full sky from ground.

  16. The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics.

    PubMed

    Asdahl, Peter H; Winther, Jeanette F; Bonnesen, Trine G; De Fine Licht, Sofie; Gudmundsdottir, Thorgerdur; Anderson, Harald; Madanat-Harjuoja, Laura; Tryggvadottir, Laufey; Småstuen, Milada Cvancarova; Holmqvist, Anna Sällfors; Hasle, Henrik; Olsen, Jørgen H

    2015-12-01

    During the last five decades, survival of childhood cancer has increased from 25% to 80%. At the same time, however, it has become evident that survivors experience a broad range of therapy-related late adverse health effects. The aim of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study is to investigate long-term health consequences of past and current therapies in order to improve follow-up care of survivors and to reduce treatment-related morbidity of future patients. Childhood cancer survivors were identified through the five Nordic cancer registries and a comparison cohort was established through random selection of cancer-free individuals from the civil registration systems. A unique personal identification number was used to link between different health registries. Abstraction of treatment information for a subset of survivors allows investigation of the association between the various components of cancer therapy and late occurring comorbidity. The childhood cancer survivor cohort comprises 33,160 1-year survivors and the comparison cohort comprises 212,892 cancer free individuals from the general population. In the childhood cancer survivor cohort, all types of childhood cancer are represented including leukemia (21%), lymphoma (14%), central nervous system tumors (24%), sarcomas (5%), retinoblastoma (3%), and neuroblastoma (4%). Among the survivors, 22% have been followed beyond the age of 40 years. The ALiCCS study constitutes a new large resource for research on late effects of childhood cancers that include all types of childhood malignancies and has followed a large proportion of the survivors well into late adulthood. © 2015 Wiley Periodicals, Inc.

  17. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-4-ol) ester of cy-clo-ali-phatic spiroketal. 721.9527 Section 721.9527 Protection of Environment...-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal. (a) Chemical substance and significant new uses...-piperidin-4-ol) ester of cycloaliphatic spiroketal (PMN No. P-91-1361) is subject to reporting under...

  18. An Approach to the Stories of Sabahattin Ali within the Context of Marxist Literary Aesthetics: The Conflict between Peasants and the Intelligentsia

    ERIC Educational Resources Information Center

    Yigit, Murat

    2016-01-01

    This study will try to read the stories of Sabahattin Ali, who has written various books in Turkish, within the context of Marxist literary aesthetics, assess the types and characters in the stories of Sabahattin Ali within that framework, and observe the social levels and the gaps between them based on the relationships between the two extreme…

  19. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-4-ol) ester of cy-clo-ali-phatic spiroketal. 721.9527 Section 721.9527 Protection of Environment...-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal. (a) Chemical substance and significant new uses...-piperidin-4-ol) ester of cycloaliphatic spiroketal (PMN No. P-91-1361) is subject to reporting under this...

  20. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-4-ol) ester of cy-clo-ali-phatic spiroketal. 721.9527 Section 721.9527 Protection of Environment...-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal. (a) Chemical substance and significant new uses...-piperidin-4-ol) ester of cycloaliphatic spiroketal (PMN No. P-91-1361) is subject to reporting under this...

  1. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-4-ol) ester of cy-clo-ali-phatic spiroketal. 721.9527 Section 721.9527 Protection of Environment...-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal. (a) Chemical substance and significant new uses...-piperidin-4-ol) ester of cycloaliphatic spiroketal (PMN No. P-91-1361) is subject to reporting under this...

  2. Identification of Antifungal Substances of Lactobacillus sakei subsp. ALI033 and Antifungal Activity against Penicillium brevicompactum Strain FI02

    PubMed Central

    Huh, Chang Ki; Hwang, Tae Yean

    2016-01-01

    This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear zones, suggesting that the antifungal substances produced by ALI033 were non-protein substances unaffected by protesases. Both, the control and catalase showed clear zones, suggesting that the antifungal metabolite was not H2O2. The molecular weights of the antifungal substances were ≤3,000 Da. The organic acid content of crude antifungal substances produced by L. sakei subsp. ALI033 showed high concentrations of lactic acid (502.47 mg/100 g). Therefore, these results suggest that antifungal substance produced by L. sakei subsp. ALI033 is most likely due to its ability in producing organic acid. PMID:27069906

  3. Identification of Antifungal Substances of Lactobacillus sakei subsp. ALI033 and Antifungal Activity against Penicillium brevicompactum Strain FI02.

    PubMed

    Huh, Chang Ki; Hwang, Tae Yean

    2016-03-01

    This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear zones, suggesting that the antifungal substances produced by ALI033 were non-protein substances unaffected by protesases. Both, the control and catalase showed clear zones, suggesting that the antifungal metabolite was not H2O2. The molecular weights of the antifungal substances were ≤3,000 Da. The organic acid content of crude antifungal substances produced by L. sakei subsp. ALI033 showed high concentrations of lactic acid (502.47 mg/100 g). Therefore, these results suggest that antifungal substance produced by L. sakei subsp. ALI033 is most likely due to its ability in producing organic acid.

  4. The ALIS Online Circulation Control System of Danmarks Tekniske Bibliotek. Stockholm Papers in Library and Information Science.

    ERIC Educational Resources Information Center

    Barnholdt, B.; Hojer-Pedersen, N.

    This report on the Automated Library Information Control System (ALIS) of the National Technological Library of Denmark focuses on the circulation control functions of the integrated, distributed processing system, which also functions as an online catalog for a bibliographic database of approximately 120,000 records with library location codes.…

  5. The ALI-ARMS Code for Modeling Atmospheric non-LTE Molecular Band Emissions: Current Status and Applications

    NASA Technical Reports Server (NTRS)

    Kutepov, A. A.; Feofilov, A. G.; Manuilova, R. O.; Yankovsky, V. A.; Rezac, L.; Pesnell, W. D.; Goldberg, R. A.

    2008-01-01

    The Accelerated Lambda Iteration (ALI) technique was developed in stellar astrophysics at the beginning of 1990s for solving the non-LTE radiative transfer problem in atomic lines and multiplets in stellar atmospheres. It was later successfully applied to modeling the non-LTE emissions and radiative cooling/heating in the vibrational-rotational bands of molecules in planetary atmospheres. Similar to the standard lambda iterations ALI operates with the matrices of minimal dimension. However, it provides higher convergence rate and stability due to removing from the iterating process the photons trapped in the optically thick line cores. In the current ALI-ARMS (ALI for Atmospheric Radiation and Molecular Spectra) code version additional acceleration of calculations is provided by utilizing the opacity distribution function (ODF) approach and "decoupling". The former allows replacing the band branches by single lines of special shape, whereas the latter treats non-linearity caused by strong near-resonant vibration-vibrational level coupling without additional linearizing the statistical equilibrium equations. Latest code application for the non-LTE diagnostics of the molecular band emissions of Earth's and Martian atmospheres as well as for the non-LTE IR cooling/heating calculations are discussed.

  6. An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration.

    PubMed

    Ulbricht, Catherine; Conquer, Julie; Flanagan, Kelly; Isaac, Richard; Rusie, Erica; Windsor, Regina C

    2013-03-01

    An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

  7. Sepsis-induced acute lung injury (ALI) is milder in diabetic rats and correlates with impaired NFkB activation.

    PubMed

    Filgueiras, Luciano R; Martins, Joilson O; Serezani, Carlos H; Capelozzi, Vera L; Montes, Marlise B A; Jancar, Sonia

    2012-01-01

    Acute lung injury (ALI) develops in response to a direct insult to the lung or secondarily to a systemic inflammatory response, such as sepsis. There is clinical evidence that the incidence and severity of ALI induced by direct insult are lower in diabetics. In the present study we investigated whether the same occurs in ALI secondarily to sepsis and the molecular mechanisms involved. Diabetes was induced in male Wistar rats by alloxan and sepsis by caecal ligation and puncture surgery (CLP). Six hours later, the lungs were examined for oedema and cell infiltration in bronchoalveolar lavage. Alveolar macrophages (AMs) were cultured in vitro for analysis of IκB and p65 subunit of NFκB phosphorylation and MyD88 and SOCS-1 mRNA. Diabetic rats were more susceptible to sepsis than non-diabetics. In non-diabetic rats, the lung presented oedema, leukocyte infiltration and increased COX2 expression. In diabetic rats these inflammatory events were significantly less intense. To understand why diabetic rats despite being more susceptible to sepsis develop milder ALI, we examined the NFκB activation in AMs of animals with sepsis. Whereas in non-diabetic rats the phosphorylation of IκB and p65 subunit occurred after 6 h of sepsis induction, this did not occur in diabetics. Moreover, in AMs from diabetic rats the expression of MyD88 mRNA was lower and that of SOCS-1 mRNA was increased compared with AMs from non-diabetic rats. These results show that ALI secondary to sepsis is milder in diabetic rats and this correlates with impaired activation of NFκB, increased SOCS-1 and decreased MyD88 mRNA.

  8. Characterization of an Alginate Lyase, FlAlyA, from Flavobacterium sp. Strain UMI-01 and Its Expression in Escherichia coli

    PubMed Central

    Inoue, Akira; Takadono, Kohei; Nishiyama, Ryuji; Tajima, Kenji; Kobayashi, Takanori; Ojima, Takao

    2014-01-01

    A major alginate lyase, FlAlyA, was purified from the periplasmic fraction of an alginate-assimilating bacterium, Flavobacterium sp. strain UMI-01. FlAlyA showed a single band of ~30 kDa on SDS-PAGE and exhibited the optimal temperature and pH at 55 °C and pH 7.7, respectively. Analyses for substrate preference and reaction products indicated that FlAlyA was an endolytic poly(mannuronate) lyase (EC 4.2.2.3). A gene fragment encoding the amino-acid sequence of 288 residues for FlAlyA was amplified by inverse PCR. The N-terminal region of 21 residues except for the initiation Met in the deduced sequence was predicted as the signal peptide and the following region of six residues was regarded as propeptide, while the C-terminal region of 260 residues was regarded as the polysaccharide-lyase-family-7-type catalytic domain. The entire coding region for FlAlyA was subjected to the pCold I—Escherichia coli BL21(DE3) expression system and ~eight times higher yield of recombinant FlAlyA (recFlAlyA) than that of native FlAlyA was achieved. The recFlAlyA recovered in the periplasmic fraction of E. coli had lost the signal peptide region along with the N-terminal 3 residues of propeptide region. This suggested that the signal peptide of FlAlyA could function in part in E. coli. PMID:25153766

  9. Lithospheric mantle evolution in the Afro-Arabian domain: Insights from Bir Ali mantle xenoliths (Yemen)

    NASA Astrophysics Data System (ADS)

    Sgualdo, P.; Aviado, K.; Beccaluva, L.; Bianchini, G.; Blichert-Toft, J.; Bryce, J. G.; Graham, D. W.; Natali, C.; Siena, F.

    2015-05-01

    Detailed petrological and geochemical investigations of an extensive sampling of mantle xenoliths from the Neogene-Quaternary Bir Ali diatreme (southern Yemen) indicate that the underlying lithospheric mantle consists predominantly of medium- to fine-grained (often foliated) spinel-peridotites (85-90%) and spinel-pyroxenites (10-15%) showing thermobarometric estimates in the P-T range of 0.9-2.0 GPa and 900-1150 °C. Peridotites, including lherzolites, harzburgites and dunites delineate continuous chemical, modal and mineralogical variations compatible with large extractions of basic melts occurring since the late Proterozoic (~ 2 Ga, according to Lu-Hf model ages). Pyroxenites may represent intrusions of subalkaline basic melts interacting and equilibrated with the host peridotite. Subsequent metasomatism has led to modal changes, with evidence of reaction patches and clinopyroxene and spinel destabilization, as well as formation of new phases (glass, amphibole and feldspar). These changes are accompanied by enrichment of the most incompatible elements and isotopic compositions. 143Nd/144Nd ranges from 0.51419 to 0.51209 (εNd from + 30.3 to - 10.5), 176Hf/177Hf from 0.28459 to 0.28239 (εHf from + 64.4 to - 13.6), and 208Pb/204Pb from 36.85 to 41.56, thus extending from the depleted mantle (DM) towards the enriched OIB mantle (EM and HIMU) components. 3He/4He (R/RA) ratios vary from 7.2 to 7.9 with He concentrations co-varying with the most incompatible element enrichment, in parallel with metasomatic effects. These metasomatic events, particularly effective in harzburgites and dunites, are attributable to the variable interaction with alkaline basic melts related to the general extensional and rifting regime affecting the East Africa-Arabian domain during the Cenozoic. In this respect, Bir Ali mantle xenoliths resemble those occurring along the Arabian margins and the East Africa Rift system, similarly affected by alkaline metasomatism, whereas they are

  10. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist.

    PubMed

    Salih, Mustafa Abdalla M

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 - 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (1952 - 1962). He made valuable contributions by his services in the vaccine production and implementation programs, most notably in combating small pox, rabies and epidemic meningitis. In 1963 he became the first Sudanese Professor of Microbiology and Parasitology and served as the first Sudanese Dean of the Faculty of Medicine, U of K (1963-1969). He was an active loyal citizen in public life and served in various fields outside the medical profession. As Mayor of Omdurman, he was invited to visit Berlin in 1963 by Willy Brandt, Mayor of West Berlin (1957-1966) and Chancellor of the Federal Republic of Germany (1969 to 1974). Also as Mayor of Omdurman, he represented the City in welcoming Queen Elizabeth II during her visit to Sudan in February 1965. He also received State Medals from Egypt and Ethiopia. In 1973 he was appointed Chairman of the Sudan Medical Research Council, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO for his contribution in the advancement of health, research and medical services.

  11. Digital Workflow for the Conservation of Bahrain Built Heritage: the Sheik Isa Bin ALI House

    NASA Astrophysics Data System (ADS)

    Barazzetti, L.; Mezzino, D.; Santana Quintero, M.

    2017-08-01

    Currently, the commercial market offers several tools for digital documentation of historic sites and buildings. Photogrammetry and laser scanning play a fundamental role in the acquisition of metric information, which is then processed to generate reliable records particularly useful also in the built heritage conservation field. Although potentially very fast and accurate, such techniques require expert operators to produce reliable results, especially in the case of complex and large sites. The aim of this paper is to present the digital workflow developed for data acquisition and processing of the Shaikh Isa Bin Ali house in Muharraq, Bahrain. This historic structure is an outstanding example of Bahrain architecture as well as tangible memory of the country history, with strong connotations in the Bahrain cultural identity. The building has been documented employing several digital techniques, including: aerial (drone) and terrestrial photogrammetry, rectifying photography, total station and laser scanning. The documentation project has been developed for the Bahrain Authority for Culture and Antiquities (BACA) by a multidisciplinary team of experts from Carleton Immersive Media Studio (CIMS, Carleton University, Canada) and Gicarus Lab (Politecnico di Milano, Italy).

  12. Remembering Ali Alpar's Early Work, and: Three Types of Neutron Stars?

    NASA Astrophysics Data System (ADS)

    van den Heuvel, E. P. J.

    2011-09-01

    Some memories of Ali Alpar and his early work are presented, with particular emphasis on his work on the origin of milliscond pulsars. After this, arguments are summarized, indicating the existence of three categories of neutron stars, with two different formation mechanisms: (i) A low-mass category ( M~1.25 +/- 0.05 solar masses), characterized by low kick velocities. These neutron stars most probably formed by electron-capture collapse in degenerate O-Ne-Mg cores of stars of initial masses between ~8 and ~11 solar masses. (ii) An intermediate-mass category (M~1.40 +/- 0.10 solar masses), characterized by high kick velocities. These stars formed by the collapse of the iron cores of stars with initial masses probably between ~11 and ~19 solar masses. (iii) A category of massive neutron stars (M >= 1.70 solar masses), also characterized by high space velocities, and formed by the collapse of the iron cores, in this case of stars with intial masses >19 solar mases.

  13. A Review of Ferdous al-Hekma fil-Tibb by Ali ibn Raban Tabari

    PubMed Central

    Ardalan, Mohammadreza; Khodadoust, Kazem; Mostafidi, Elmira

    2015-01-01

    T Ferdous al-Hekma (Paradise of Wisdom) is one of the oldest medical texts in the Islamic world written in Arabic in 850 AD by Ali ibn Raban Tabari. He was a Persian physician who moved from Tabaristan (Mazandaran province of modern day Iran) to Samarra during the reign of the Abbasid Caliph al-Mutawakkil (847-861 AD). We studied the book of Ferdous al-Hekma fil-Tibb, in an attempt to comprehend its general outlook on diseases of different organs, their classifications and the associated signs and symptoms. The book is one of the earliest medical pandects of the period of translation, adaptation and expansion of knowledge in the Islamic world during the 9th century AD. Tabari was mainly influenced by Hippocrates, Galen and Aristotle, as well as his contemporaries Johanna ibn Massavieh and Hunayn ibn Ishaq. The book is written in thirty chapters in a total number of 308 subtitles. In each part there is an introduction to the symptomatology, followed by organ specific diseases and therapeutic recommendations. Symptoms and physical signs of different diseases are vividly described in Ferdous al-Hekma, and some of them are even understandable for contemporary medical students. PMID:27350863

  14. Determination of mercury by cold vapor atomic absorption spectrophotometer in Tongkat Ali preparations obtained in Malaysia.

    PubMed

    Ang, Hooi-Hoon; Lee, Ee-Lin; Cheang, Hui-Seong

    2004-01-01

    The DCA (Drug Control Authority), Malaysia, has implemented the phase 3 registration of traditional medicines on 1 January 1992, with special emphasis on the quality, efficacy, and safety (including the presence of heavy metals) in all pharmaceutical dosage forms of traditional medicine preparations. As such, a total of 100 products in various pharmaceutical dosage forms of a herbal preparation, containing Tongkat Ali, were analyzed for mercury content using cold vapor atomic absorption spectrophotometer. Results showed that 36% of the above products possessed 0.52 to 5.30 ppm of mercury and, therefore, do not comply with the quality requirement for traditional medicines in Malaysia. Out of these 36 products, 5 products that possessed 1.05 to 4.41 ppm of mercury were in fact have already registered with the DCA, Malaysia. However, the rest of the products that contain 0.52 to 5.30 ppm of mercury still have not registered with the DCA, Malaysia. Although this study showed that only 64% of the products complied with the quality requirement for traditional medicines in Malaysia pertaining to mercury, they cannot be assumed safe from mercury contamination because of batch-to-batch inconsistency.

  15. In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat.

    PubMed

    Solomon, M C; Erasmus, N; Henkel, R R

    2014-05-01

    An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm parameters in terms of safety and efficacy in the management of male infertility. Forty-two male rats were divided into a control, low-dose (200 mg kg(-1) BW) and high-dose (800 mg kg(-1) BW) group (n = 14). Rats were force-fed for 14 days and then sacrificed. Total body and organ weights of the prostate, testes, epididymides, gastrocnemius muscle and the omentum were recorded. Moreover, testosterone concentration, sperm concentration, motility, velocity, vitality, acrosome reaction and mitochondrial membrane potential (MMP) were assessed. Whilst TA decreased BW by 5.7% (P = 0.0276) and omentum fat by 31.9% (P = 0.0496), no changes in organ weights were found for the prostate, testes and epididymides. Testosterone concentration increased by 30.2% (P = 0.0544). Muscle weight also increased, yet not significantly. Whilst sperm concentration, total and progressive motility and vitality increased significantly, MMP improved markedly (P = 0.0765) by 25.1%. Because no detrimental effect could be observed, TA appears safe for possible treatment of male infertility and ageing male problems.

  16. Effect of Eurycoma longifolia Jack (Tongkat ali) extract on human spermatozoa in vitro.

    PubMed

    Erasmus, N; Solomon, M C; Fortuin, K A; Henkel, R R

    2012-10-01

    Eurycoma longifolia (Tongkat ali; TA) is a Malaysian shrub used to treat various illnesses including male infertility. Considering that TA is used to improve male fertility and no report regarding its safety has been published, this study investigated the effects of TA extract on various sperm functions. Semen samples of 27 patients and 13 donors were divided into two groups, washed and swim-up spermatozoa, and incubated with different concentrations of TA (1, 10, 20, 100, 2000 μg ml(-1) ) for 1 h at 37 °C. A sample without addition of TA served as control. For washed spermatozoa, significant dose-dependent trends were found for vitality, total motility, acrosome reaction and reactive oxygen species-positive spermatozoa. However, these trends were only significant if the highest concentrations were included in the calculation. Contrary, the increase in the percentage of acrosome-reacted spermatozoa with increasing TA concentrations is very significant (P < 0.0001), and a significant difference (P = 0.0069) to the control could even be recorded at 20 μg TA per ml. For swim-up spermatozoa, no trend could be observed. Results indicate that the TA extract has no deleterious effects on sperm functions at therapeutically used concentrations (<2.5 μg ml(-1) ). However, at very high concentrations, TA may have harmful effects in vitro.

  17. Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus.

    PubMed

    Huang, Hsiu-Chen; Lee, Chung-Pei; Liu, Hui-Kang; Chang, Ming-Fu; Lai, Yu-Heng; Lee, Yu-Ching; Huang, Cheng

    2016-12-09

    Hepatitis delta virus (HDV) is a satellite virus of hepatitis B virus (HBV). HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), which is required for viral replication, and large HDAg (HDAg-L), which is essential for viral assembly. HDAg-L is identical to HDAg-S except that it bears a 19-amino acid extension at the C terminus. Both HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclear export signal at its C terminus. The nuclear export activity of HDAg-L is important for HDV particle formation. However, the mechanisms of HDAg-L-mediated nuclear export of HDV ribonucleoprotein are not clear. In this study, the host cellular RNA export complex TAP-Aly was found to form a complex with HDAg-L, but not with an export-defective HDAg-L mutant, in which Pro(205) was replaced by Ala. HDAg-L was found to colocalize with TAP and Aly in the nucleus. The C-terminal domain of HDAg-L was shown to directly interact with the N terminus of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP. In addition, small hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT-HDAg-L(198-210), containing the 10-amino acid TAT peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion. These data demonstrate that formation and release of HDV particles are mediated by TAP and Aly.

  18. LocalAli: an evolutionary-based local alignment approach to identify functionally conserved modules in multiple networks.

    PubMed

    Hu, Jialu; Reinert, Knut

    2015-02-01

    Sequences and protein interaction data are of significance to understand the underlying molecular mechanism of organisms. Local network alignment is one of key systematic ways for predicting protein functions, identifying functional modules and understanding the phylogeny from these data. Most of currently existing tools, however, encounter their limitations, which are mainly concerned with scoring scheme, speed and scalability. Therefore, there are growing demands for sophisticated network evolution models and efficient local alignment algorithms. We developed a fast and scalable local network alignment tool called LocalAli for the identification of functionally conserved modules in multiple networks. In this algorithm, we firstly proposed a new framework to reconstruct the evolution history of conserved modules based on a maximum-parsimony evolutionary model. By relying on this model, LocalAli facilitates interpretation of resulting local alignments in terms of conserved modules, which have been evolved from a common ancestral module through a series of evolutionary events. A meta-heuristic method simulated annealing was used to search for the optimal or near-optimal inner nodes (i.e. ancestral modules) of the evolutionary tree. To evaluate the performance and the statistical significance, LocalAli were tested on 26 real datasets and 1040 randomly generated datasets. The results suggest that LocalAli outperforms all existing algorithms in terms of coverage, consistency and scalability, meanwhile retains a high precision in the identification of functionally coherent subnetworks. The source code and test datasets are freely available for download under the GNU GPL v3 license at https://code.google.com/p/localali/. jialu.hu@fu-berlin.de or knut.reinert@fu-berlin.de. Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS.

    PubMed

    Tsangaris, Iraklis; Tsantes, Argiris; Bonovas, Stefanos; Lignos, Michalis; Kopterides, Petros; Gialeraki, Argiro; Rapti, Evdoxia; Orfanos, Stylianos; Dimopoulou, Ioanna; Travlou, Anthi; Armaganidis, Apostolos

    2009-04-01

    Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with worse outcome in ALI/ARDS. A single guanosine insertion/deletion (4G/5G) polymorphism in the promoter region of the PAI-1 gene, may play an important role in the regulation of PAI-1 expression. The objective of the study was to evaluate the effect of this polymorphism on the outcome of critically ill patients with ALI/ARDS. 52 consecutive ventilated patients with ALI/ARDS were studied. Bronchoalveolar lavage was performed within 48 hours from diagnosis. Measurement of plasma and BALF PAI-1 activity and D-dimers levels, and 4G/5G genotyping of PAI-1 were carried out. The primary outcome was 28-day mortality, and secondary outcomes included organ dysfunction and ventilator-free days. 17 patients were homozygotes for the 4G allele. Severity scores were not different between subgroups upon study enrollment. 28-day mortality was 70.6% and 42.9% for the 4G-4G and the non-4G-4G patients, respectively (p=0.06). PAI-1 activity levels and D-dimer in plasma and BALF were not significantly different between the 4G-4G and the non-4G-4G subgroups. In the multivariate analysis, genotype 4G/4G was the only variable independently associated with 28-day mortality (Odds Ratio=9.95, 95% CI: 1.79-55.28, p=0.009). Furthermore, genotype 4G/4G and plasma PAI-1 activity levels were independently negatively associated with ventilator free days (p=0.033 and p=0.008, respectively). ALI/ARDS patients, homozygous for the 4G allele of the PAI-1 gene, experienced higher 28-day mortality. This genotype was associated with a reduction in the number of days of unassisted ventilation and was inversely associated with the number of days without organ failure.

  20. Mapping forest height, foliage height profiles and disturbance characteristics with time series of gap-filled Landsat and ALI imagery

    NASA Astrophysics Data System (ADS)

    Helmer, E.; Ruzycki, T. S.; Wunderle, J. M.; Kwit, C.; Ewert, D. N.; Voggesser, S. M.; Brandeis, T. J.

    2011-12-01

    We mapped tropical dry forest height (RMSE = 0.9 m, R2 = 0.84, range 0.6-7 m) and foliage height profiles with a time series of gap-filled Landsat and Advanced Land Imager (ALI) imagery for the island of Eleuthera, The Bahamas. We also mapped disturbance type and age with decision tree classification of the image time series. Having mapped these variables in the context of studies of wintering habitat of an endangered Nearctic-Neotropical migrant bird, the Kirtland's Warbler (Dendroica kirtlandii), we then illustrated relationships between forest vertical structure, disturbance type and counts of forage species important to the Kirtland's Warbler. The ALI imagery and the Landsat time series were both critical to the result for forest height, which the strong relationship of forest height with disturbance type and age facilitated. Also unique to this study was that seven of the eight image time steps were cloud-gap-filled images: mosaics of the clear parts of several cloudy scenes, in which cloud gaps in a reference scene for each time step are filled with image data from alternate scenes. We created each cloud-cleared image, including a virtually seamless ALI image mosaic, with regression tree normalization of the image data that filled cloud gaps. We also illustrated how viewing time series imagery as red-green-blue composites of tasseled cap wetness (RGB wetness composites) aids reference data collection for classifying tropical forest disturbance type and age.

  1. Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital

    PubMed Central

    Hasheminasab Zaware, Roshanak; Mahmoodi Meymand, Mohammad Hossein; Rezaeian, Mohsen; Mohammadi Kamalabadi, Niloofar; Mostafavi, Seyed-Ali; Abdolkarimi Dawarani, Mohammad Ali; Jome Yazdian, Reyhane; Bidaki, Reza

    2016-01-01

    Background: Sleep is one of the most fundamental human needs; without any doubt sleep is even more essential for sick patients, especially for patients with chronic illnesses. Sleep disturbance may lead to anxiety and reduced quality of life. Restless leg syndrome (RLS) is a sensory-motor disorder accompanied by a strong desire to move the legs or other parts of the body, which can cause sleep disturbance. Its etiology is unknown, but increased urea and creatinine levels before dialysis, iron deficiency due to kidney failure and end-stage renal disease (ESRD) are mentioned as causes. Objectives: This study is designed to examine the prevalence of insomnia and restless leg syndrome in patients undergoing chronic hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital. Patients and Methods: In this study we used two questionnaires to evaluate the presence of RLS and insomnia in ESRD patients who were undergoing hemodialysis treatment as kidney replacement therapy. Results: According to our results, 54.5% of patients were diagnosed with RLS, and of those 65.2% and 42.9% were women and men, respectively. RLS is seen more often among patients with blood group type A, but this result was not statistically significant. There was a statistically significant correlation between RLS and a positive family history of RLS, between RLS and the number of hemodialysis treatments per week and also between RLS and the Insomnia Severity Index. Unlike previous studies, in this study we did not find any statistically significant correlation between RLS and biochemical factors such as serum iron, TIBC, BUN, creatinine, potassium, calcium and phosphorous levels. Conclusions: The frequency of RLS among our patients was remarkable and we conclude that all patients who are undergoing hemodialysis should be screened for RLS, which can assist in providing proper attention and treatment. PMID:26981494

  2. Insomnia and Restless Leg Syndrome in Patients Undergoing Chronic Hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital.

    PubMed

    Hasheminasab Zaware, Roshanak; Mahmoodi Meymand, Mohammad Hossein; Rezaeian, Mohsen; Mohammadi Kamalabadi, Niloofar; Mostafavi, Seyed-Ali; Abdolkarimi Dawarani, Mohammad Ali; Jome Yazdian, Reyhane; Bidaki, Reza

    2016-01-01

    Sleep is one of the most fundamental human needs; without any doubt sleep is even more essential for sick patients, especially for patients with chronic illnesses. Sleep disturbance may lead to anxiety and reduced quality of life. Restless leg syndrome (RLS) is a sensory-motor disorder accompanied by a strong desire to move the legs or other parts of the body, which can cause sleep disturbance. Its etiology is unknown, but increased urea and creatinine levels before dialysis, iron deficiency due to kidney failure and end-stage renal disease (ESRD) are mentioned as causes. This study is designed to examine the prevalence of insomnia and restless leg syndrome in patients undergoing chronic hemodialysis in Rafsanjan Ali Ibn Abitaleb Hospital. In this study we used two questionnaires to evaluate the presence of RLS and insomnia in ESRD patients who were undergoing hemodialysis treatment as kidney replacement therapy. According to our results, 54.5% of patients were diagnosed with RLS, and of those 65.2% and 42.9% were women and men, respectively. RLS is seen more often among patients with blood group type A, but this result was not statistically significant. There was a statistically significant correlation between RLS and a positive family history of RLS, between RLS and the number of hemodialysis treatments per week and also between RLS and the Insomnia Severity Index. Unlike previous studies, in this study we did not find any statistically significant correlation between RLS and biochemical factors such as serum iron, TIBC, BUN, creatinine, potassium, calcium and phosphorous levels. The frequency of RLS among our patients was remarkable and we conclude that all patients who are undergoing hemodialysis should be screened for RLS, which can assist in providing proper attention and treatment.

  3. Alteration zone Mapping in the Meiduk and Sar Cheshmeh Porphyry Copper Mining Districts of Iran using Advanced Land Imager (ALI) Satellite Data

    NASA Astrophysics Data System (ADS)

    Beiranvand Pour, A.; Hashim, M.

    2015-10-01

    This study evaluates the capability of Earth Observing-1 (EO1) Advanced Land Imager (ALI) data for hydrothermal alteration mapping in the Meiduk and Sar Cheshmeh porphyry copper mining districts, SE Iran. Feature-oriented principal components selection, 4/2, 8/9, 5/4 band ratioing were applied to ALI data for enhancing the hydrothermally altered rocks associated with porphyry copper mineralization, lithological units and vegetation. Mixture-tuned matched-filtering (MTMF) was tested to discriminate the hydrothermal alteration areas of porphyry copper mineralization from surrounding environment using the shortwave infrared bands of ALI. Results indicate that the tested methods are able to yield spectral information for identifying vegetation, iron oxide/hydroxide and clay minerals, lithological units and the discrimination of hydrothermally altered rocks from unaltered rocks using ALI data.

  4. 75 FR 2921 - In the Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE In the Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as Abu-Sufyan al-Azidi, Also Known as Abu-Sayyaf al-Shihri, Also Known as Abu Sufian Kadhdhaab Matrook, Also Known as Sa'id Ali Jabir al-Khathim al-Shihri,...

  5. Effects of Rapid Thermal Annealing and Different Oxidants on the Properties of LaxAlyO Nanolaminate Films Deposited by Atomic Layer Deposition

    NASA Astrophysics Data System (ADS)

    Fei, Chenxi; Liu, Hongxia; Wang, Xing; Zhao, Lu; Zhao, Dongdong; Feng, Xingyao

    2017-03-01

    A comparative study of different sequences of two metal precursors [trimethylaluminum (TMA) and Tris(isopropylcyclopentadienyl) lanthanum (La(iPrCp)3)] for atomic layer deposition (ALD) lanthanum aluminum oxide (LaxAlyO) films is carried out. The percentage compositions of C and N impurity of LaxAlyO films were investigated using in situ X-ray photoelectron spectroscopy (XPS). The effects of different oxidants on the physical and chemical properties and electrical characteristics of LaxAlyO films are studied before and after annealing. Preliminary testing results indicate that the impurity level of LaxAlyO films grown with different oxidants can be well controlled before and after annealing. Analysis indicates the rapid thermal annealing (RTA) and kinds of oxidants have significant effects on the equivalent oxide thickness (EOT), dielectric constant, electrical properties, and stability of LaxAlyO films. Additionally, the change of chemical bond types of rapid thermal annealing effects on the properties of LaxAlyO films are grown with different oxidants also investigated by XPS.

  6. Mineral mapping on the Chilean-Bolivian Altiplano using co-orbital ALI, ASTER and Hyperion imagery: Data dimensionality issues and solutions

    USGS Publications Warehouse

    Hubbard, B.E.; Crowley, J.K.

    2005-01-01

    Hyperspectral data coverage from the EO-1 Hyperion sensor was useful for calibrating Advanced Land Imager (ALI) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) images of a volcanic terrane area of the Chilean-Bolivian Altiplano. Following calibration, the ALI and ASTER datasets were co-registered and joined to produce a 13-channel reflectance cube spanning the Visible to Short Wave Infrared (0.4-2.4 ??m). Eigen analysis and comparison of the Hyperion data with the ALI + ASTER reflectance data, as well as mapping results using various ALI+ASTER data subsets, provided insights into the information dimensionality of all the data. In particular, high spectral resolution, low signal-to-noise Hyperion data were only marginally better for mineral mapping than the merged 13-channel, low spectral resolution, high signal-to-noise ALI + ASTER dataset. Neither the Hyperion nor the combined ALI + ASTER datasets had sufficient information dimensionality for mapping the diverse range of surface materials exposed on the Altiplano. However, it is possible to optimize the use of the multispectral data for mineral-mapping purposes by careful data subsetting, and by employing other appropriate image-processing strategies.

  7. Effects of Rapid Thermal Annealing and Different Oxidants on the Properties of LaxAlyO Nanolaminate Films Deposited by Atomic Layer Deposition.

    PubMed

    Fei, Chenxi; Liu, Hongxia; Wang, Xing; Zhao, Lu; Zhao, Dongdong; Feng, Xingyao

    2017-12-01

    A comparative study of different sequences of two metal precursors [trimethylaluminum (TMA) and Tris(isopropylcyclopentadienyl) lanthanum (La((i)PrCp)3)] for atomic layer deposition (ALD) lanthanum aluminum oxide (LaxAlyO) films is carried out. The percentage compositions of C and N impurity of LaxAlyO films were investigated using in situ X-ray photoelectron spectroscopy (XPS). The effects of different oxidants on the physical and chemical properties and electrical characteristics of LaxAlyO films are studied before and after annealing. Preliminary testing results indicate that the impurity level of LaxAlyO films grown with different oxidants can be well controlled before and after annealing. Analysis indicates the rapid thermal annealing (RTA) and kinds of oxidants have significant effects on the equivalent oxide thickness (EOT), dielectric constant, electrical properties, and stability of LaxAlyO films. Additionally, the change of chemical bond types of rapid thermal annealing effects on the properties of LaxAlyO films are grown with different oxidants also investigated by XPS.

  8. Landslide detection using LiDAR data and data mining technology: Ali Mountain Highway case study (Taiwan)

    NASA Astrophysics Data System (ADS)

    Cheng, Youg-Sin; Yu, Teng-To; Tarolli, Paolo

    2017-04-01

    Taiwan mountains are severely affected each year by landslides, rock falls, and debris flows where the roads system suffer the most critical consequences. Among all mountain highways, Ali Highway, located into the main entrance of Alishan Mountain region, is one of the most landslide-prone areas in southern Taiwan. During the typhoon season, between May and August, the probability of occurrence of mass movements is at higher level than usual seeing great erosion rates. In fact, during Typhoon Morakot, in 2009, the intense rainfall caused abrupt interruption of the circulation for three months triggering several landslides (Liu et al. 2012). The topographic features such as slope, roughness and curvature among others have been extracted from 1 m DTM derived by a LiDAR dataset (collected in 2015) to investigate the slope failures along the Ali Mountain Highway. The high-resolution DTM highlighted that the hydrogeomorphological (e.g. density of stream, the distance from the ridge and terrain) features are one of the most influencing factors affecting the change and the instability of the slopes. To detect the landslide area, the decision tree classifier and the random forest algorithm (RF) have been adopted. The results provided a suitable analysis of the area involved in the failure. This will be a useful step in the understanding (and management) landslide processes of study area. References Liu CN, Dong JJ, Chen CJ, Lee WF (2012) Typical landslides and related mechanisms in Ali Mountain highway induced by typhoon Morakot: Perspectives from engineering geology. Landslides 9:239-254.

  9. Characterizing magnetospheric electrons from ALIS observations of discrete auroral arcs and quasi-stationary modeling of auroral acceleration

    NASA Astrophysics Data System (ADS)

    Lamy, H.; Simon, C.; Echim, M.; de Keyser, J. M.; Gustavsson, B.; Sergienko, T.; Sandahl, I.; Brandstrom, U.

    2010-12-01

    From a series of images obtained simultaneously with the CCD cameras of the ALIS (Auroral Large Imaging System) network located in Scandinavia, three-dimensional (3D) large-scale structures of discrete auroral arcs can be retrieved in several filters with tomography-like techniques. In particular, the 3D reconstructed volume emission rates at 4278 Å can be used to derive the energy spectra of precipitating magnetospheric electrons in 2D, along and across the arc, with a spatial resolution of approximately 3 km. These spectra directly provide E0, the characteristic energy and ɛm, the total flux energy of precipitating electrons. The latter can be used together with a kinetic modelling of adiabatic motion of particles (Lundin & Sandahl, 1978) and assuming a Maxwellian distribution for magnetospheric electrons, to derive ΔΦ, the field-aligned potential difference between the ionosphere and magnetosphere. The next step is to use a quasi-static magnetosphere-ionosphere coupling model based on the current continuity in the ionosphere (Echim et al, 2007) and the model of tangential discontinuity generators (Roth et al 1993) to determine densities (ne) and temperatures (Te) of the magnetospheric electrons. The model is run iteratively for typical values of magnetospheric ne and Te that are adjusted until ΔΦ provided by the model is in agreement with the one determined from ALIS observations. This technique allows to obtain information about the properties of the generator of the auroral arc, from ground-based observations and quasi-stationary modeling. Future conjugated observations between ALIS and a spacecraft crossing the same magnetic field lines above the acceleration region could be used to validate this novel technique.

  10. AliBiMotif: integrating alignment and biclustering to unravel transcription factor binding sites in DNA sequences.

    PubMed

    Gonçalves, Joana P; Moreau, Yves; Madeira, Sara C

    2012-01-01

    Transcription Factors (TFs) control transcription by binding to specific sites in the promoter regions of the target genes, which can be modelled by structured motifs. In this paper we propose AliBiMotif, a method combining sequence alignment and a biclustering approach based on efficient string matching techniques using suffix trees to unravel approximately conserved sets of blocks (structured motifs) while straightforwardly disregarding non-conserved stretches in-between. The ability to ignore the width of non-conserved regions is a major advantage of the proposed method over other motif finders, as the lengths of the binding sites are usually easier to estimate than the separating distances.

  11. Examining Reliability and Validity of an Online Score (ALiEM AIR) for Rating Free Open Access Medical Education Resources.

    PubMed

    Chan, Teresa Man-Yee; Grock, Andrew; Paddock, Michael; Kulasegaram, Kulamakan; Yarris, Lalena M; Lin, Michelle

    2016-12-01

    Since 2014, Academic Life in Emergency Medicine (ALiEM) has used the Approved Instructional Resources (AIR) score to critically appraise online content. The primary goals of this study are to determine the interrater reliability (IRR) of the ALiEM AIR rating score and determine its correlation with expert educator gestalt. We also determine the minimum number of educator-raters needed to achieve acceptable reliability. Eight educators each rated 83 online educational posts with the ALiEM AIR scale. Items include accuracy, usage of evidence-based medicine, referencing, utility, and the Best Evidence in Emergency Medicine rating score. A generalizability study was conducted to determine IRR and rating variance contributions of facets such as rater, blogs, posts, and topic. A randomized selection of 40 blog posts previously rated through ALiEM AIR was then rated again by a blinded group of expert medical educators according to their gestalt. Their gestalt impression was subsequently correlated with the ALiEM AIR score. The IRR for the ALiEM AIR rating scale was 0.81 during the 6-month pilot period. Decision studies showed that at least 9 raters were required to achieve this reliability. Spearman correlations between mean AIR score and the mean expert gestalt ratings were 0.40 for recommendation for learners and 0.35 for their colleagues. The ALiEM AIR scale is a moderately to highly reliable, 5-question tool when used by medical educators for rating online resources. The score displays a fair correlation with expert educator gestalt in regard to the quality of the resources. The score displays a fair correlation with educator gestalt. Copyright © 2016 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  12. The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.

    PubMed

    Tian, Xiaochen; Devi-Rao, Gayathri; Golovanov, Alexander P; Sandri-Goldin, Rozanne M

    2013-07-01

    Herpes simplex virus 1 (HSV-1) protein ICP27 enables viral mRNA export by accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through the nuclear pore complex. ICP27 binds viral mRNAs and interacts with TAP/NXF, providing a link to the cellular mRNA export pathway. ICP27 also interacts with the mRNA export adaptor protein Aly/REF, which binds cellular mRNAs and also interacts with TAP/NXF. Studies using small interfering RNA (siRNA) knockdown indicated that Aly/REF is not required for cellular mRNA export, and similar knockdown studies during HSV-1 infection led us to conclude that Aly/REF may be dispensable for viral RNA export. Recently, the structural basis of the interaction of ICP27 with Aly/REF was elucidated at atomic resolution, and it was shown that three ICP27 residues, W105, R107, and L108, interface with the RNA recognition motif (RRM) domain of Aly/REF. Here, to determine the role the interaction of ICP27 and Aly/REF plays during infection, these residues were mutated to alanine, and a recombinant virus, WRL-A, was constructed. Virus production was reduced about 10-fold during WRL-A infection, and export of ICP27 protein and most viral mRNAs was less efficient. We conclude that interaction of ICP27 with Aly/REF contributes to efficient viral mRNA export.

  13. Zonation of flood production potential in Kabutar Ali Chai watershed using SCS model

    NASA Astrophysics Data System (ADS)

    Jananeh, Keristineh

    2015-04-01

    Kabutar Ali Chai watershed is located on the southern hillsides of Mishow mountains, 75 km northwest of Tabriz, NW Iran. This watershed is confined to 1390 and 3230 m elevation levels, where the general dip is from north to south. The watershed area is 67.46 km2 and the length of the main stream is about 24.5 km. This is one of the flood basins in the region and considering the availability of precipitation data for the 20 year interval and the possibility of flood occurrence threatening the downstream villages, the flood production investigations in order to prioritize the sub-basins regarding their flood-potential were carried out using the SCS method. In this regard, the watershed area was divided into 4 sections based on physiographic and topographic characteristics and the existing stream network: A1 (the southern and the low-height end of the watershed), A2 (the mid-western half), A3 (the mid-eastern half) and A4 (the northern and highest part). The precipitation data for 20 year interval were gathered from the nearby weather stations of Tabriz, Sahand, Marand and Sharafkhaneh based on which, the average annual precipitation is about 294 mm, with the highest amounts of 415 to 450 mm in A4 sub-basin and the lowest value of 253 mm in the southern A1 sub-basin. According to the time of concentration estimates based on the stream lengths and the elevation differences, this parameter is highest in A1 sub-basin with the rate of 1.64 h and lowest at A3 sub-basin with the rate of 0.35 h. This parameter has negative correlation with the flood production potential. The runoff height is estimated using the SCS method. In order to determine the CN curve Number, the maps of hydrologic groups of soil, land use and vegetation were prepared and combined with each other and then, by taking into account the area of each homogeneous unit, the CN number was calculated for the watershed and the related CN map was prepared. The peak discharge of the hydrologic units across the

  14. [Pathology of adaptation according to Sami-Ali and index of conformity to the Rorschach test in ulcerative rectocolitis].

    PubMed

    Porcelli, P; Zaka, S; Tarantino, S; Sisto, G

    1992-01-01

    According to Sami-Ali's theoretical model the psychosomatic personality is characterised by an adaptation pathology whose main elements are the repression of imaginative thought and conformity to socio-cultural standards. This study examines adaptation pathology using the Rorschach test. The Authors have formulated a conformity index by relating kinestheses (M) and banal perceptions (BAN). The study was carried out on a sample of 41 patients suffering from ulcerous rectocolitis comprising 24 males and 17 women with a mean age of 32 years. As expected in the hypothesis 97.6% of the sample showed M values below the norm, and 68.3% had Ban values higher than normal, whereas the conformity index was positive and tendentially positive in 65.9% of cases. These findings confirm Sami-Ali's theory. Subjects with ulcerous rectocolitis form part of the adaptation pathology which characterised the psychosomatic personality, with an inverse proportionality between imaginative activity (kinesthesia below normal) and conformism (banal perceptions above the norm).

  15. Equations of state of anhydrous AlF3 and AlI3: Modeling of extreme condition halide chemistry.

    PubMed

    Stavrou, Elissaios; Zaug, Joseph M; Bastea, Sorin; Crowhurst, Jonathan C; Goncharov, Alexander F; Radousky, Harry B; Armstrong, Michael R; Roberts, Sarah K; Plaue, Jonathan W

    2015-06-07

    Pressure dependent angle-dispersive x-ray powder diffraction measurements of alpha-phase aluminum trifluoride (α-AlF3) and separately, aluminum triiodide (AlI3) were conducted using a diamond-anvil cell. Results at 295 K extend to 50 GPa. The equations of state of AlF3 and AlI3 were determined through refinements of collected x-ray diffraction patterns. The respective bulk moduli and corresponding pressure derivatives are reported for multiple orders of the Birch-Murnaghan (B-M), finite-strain (F-f), and higher pressure finite-strain (G-g) EOS analysis models. Aluminum trifluoride exhibits an apparent isostructural phase transition at approximately 12 GPa. Aluminum triiodide also undergoes a second-order atomic rearrangement: applied stress transformed a monoclinically distorted face centered cubic (fcc) structure into a standard fcc structural arrangement of iodine atoms. Results from semi-empirical thermochemical computations of energetic materials formulated with fluorine containing reactants were obtained with the aim of predicting the yield of halogenated products.

  16. Equations of state of anhydrous AlF3 and AlI3: Modeling of extreme condition halide chemistry

    NASA Astrophysics Data System (ADS)

    Stavrou, Elissaios; Zaug, Joseph M.; Bastea, Sorin; Crowhurst, Jonathan C.; Goncharov, Alexander F.; Radousky, Harry B.; Armstrong, Michael R.; Roberts, Sarah K.; Plaue, Jonathan W.

    2015-06-01

    Pressure dependent angle-dispersive x-ray powder diffraction measurements of alpha-phase aluminum trifluoride (α-AlF3) and separately, aluminum triiodide (AlI3) were conducted using a diamond-anvil cell. Results at 295 K extend to 50 GPa. The equations of state of AlF3 and AlI3 were determined through refinements of collected x-ray diffraction patterns. The respective bulk moduli and corresponding pressure derivatives are reported for multiple orders of the Birch-Murnaghan (B-M), finite-strain (F-f), and higher pressure finite-strain (G-g) EOS analysis models. Aluminum trifluoride exhibits an apparent isostructural phase transition at approximately 12 GPa. Aluminum triiodide also undergoes a second-order atomic rearrangement: applied stress transformed a monoclinically distorted face centered cubic (fcc) structure into a standard fcc structural arrangement of iodine atoms. Results from semi-empirical thermochemical computations of energetic materials formulated with fluorine containing reactants were obtained with the aim of predicting the yield of halogenated products.

  17. Caractérisation de jonctions ultra-minces réalisées par dopage laser

    NASA Astrophysics Data System (ADS)

    Kerrien, G.; Sarnet, T.; Débarre, D.; Hernandez, M.; Zahorski, D.; Venturini, J.; Laviron, C.; Semeria, M. N.; Boulmer, J.

    2003-06-01

    Cette étude concerne les techniques de recuit laser (LTP) et de dopage laser direct (GILD) de jonctions ultra-minces, nécessaires à la fabrication des composants microélectroniques du futur (générations CMOS sub 0,1 μm). Des jonctions de 20 à 80 nm sont réalisées à l'aide d'un laser à excimères. Le procédé est suivi en temps réel grâce à l'analyse de la réflectivité transitoire à 675 nm. L'évolution de l'activation des dopants est ensuite caractérisée par spectroscopie IR (FTIR). Les résultats obtenus permettent de caractériser les jonctions en termes d'épaisseur dopées, concentration et résistivité. Une comparaison avec des caractérisations classiques (mesures électriques de résistivité, profils SIMS) permet de valider ces mesures et de mettre en évidence l'intérêt des techniques optiques pour la caractérisation in-situ et ex-situ des couches minces dopées réalisées par laser.

  18. Synthesis of Multispectral Bands from Hyperspectral Data: Validation Based on Images Acquired by AVIRIS, Hyperion, ALI, and ETM+

    NASA Technical Reports Server (NTRS)

    Blonski, Slawomir; Glasser, Gerald; Russell, Jeffrey; Ryan, Robert; Terrie, Greg; Zanoni, Vicki

    2003-01-01

    Spectral band synthesis is a key step in the process of creating a simulated multispectral image from hyperspectral data. In this step, narrow hyperspectral bands are combined into broader multispectral bands. Such an approach has been used quite often, but to the best of our knowledge accuracy of the band synthesis simulations has not been evaluated thus far. Therefore, the main goal of this paper is to provide validation of the spectral band synthesis algorithm used in the ART software. The next section contains a description of the algorithm and an example of its application. Using spectral responses of AVIRIS, Hyperion, ALI, and ETM+, the following section shows how the synthesized spectral bands compare with actual bands, and it presents an evaluation of the simulation accuracy based on results of MODTRAN modeling. In the final sections of the paper, simulated images are compared with data acquired by actual satellite sensors. First, a Landsat 7 ETM+ image is simulated using an AVIRIS hyperspectral data cube. Then, two datasets collected with the Hyperion instrument from the EO-1 satellite are used to simulate multispectral images from the ALI and ETM+ sensors.

  19. Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2 ▿

    PubMed Central

    Hatakeyama, Riko; Kamiya, Masao; Takahara, Terunao; Maeda, Tatsuya

    2010-01-01

    Endocytosis of nutrient transporters is stimulated under various conditions, such as elevated nutrient availability. In Saccharomyces cerevisiae, endocytosis is triggered by ubiquitination of transporters catalyzed by the E3 ubiquitin ligase Rsp5. However, how the ubiquitination is accelerated under certain conditions remains obscure. Here we demonstrate that closely related proteins Aly2/Art3 and Aly1/Art6, which are poorly characterized members of the arrestin-like protein family, mediate endocytosis of the aspartic acid/glutamic acid transporter Dip5. In aly2Δ cells, Dip5 is stabilized at the plasma membrane and is not endocytosed efficiently. Efficient ubiquitination of Dip5 is dependent on Aly2. aly1Δ cells also show deficiency in Dip5 endocytosis, although less remarkably than aly2Δ cells. Aly2 physically interacts in vivo with Rsp5 at its PY motif and also with Dip5, thus serving as an adaptor linking Rsp5 with Dip5 to achieve Dip5 ubiquitination. Importantly, the interaction between Aly2 and Dip5 is accelerated in response to elevated aspartic acid availability. This result indicates that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2. PMID:20956561

  20. New insights into the structure of Om Ali-Thelepte basin, central Tunisia, inferred from gravity data: Hydrogeological implications

    NASA Astrophysics Data System (ADS)

    Harchi, Mongi; Gabtni, Hakim; El Mejri, Hatem; Dassi, Lassaad; Mammou, Abdallah Ben

    2016-08-01

    This work presents new results from gravity data analyses and interpretation within the Om Ali-Thelepte (OAT) basin, central Tunisia. It focuses on the hydrogeological implication, using several qualitative and quantitative techniques such as horizontal gradient, upward continuation and Euler deconvolution on boreholes log data, seismic reflection data and electrical conductivity measurements. The structures highlighted using the filtering techniques suggest that the Miocene aquifer of OAT basin is cut by four major fault systems that trend E-W, NE-SW, NW-SE and NNE-SSW. In addition, a NW-SE gravity model established shows the geometry of the Miocene sandstone reservoir and the Upper Cretaceous limestone rocks. Moreover, the superimposition of the electrical conductivity and the structural maps indicates that the low conductivity values of sampled water from boreholes are located around main faults.

  1. Probing the structures of gold-aluminum alloy clusters AuxAly(-): a joint experimental and theoretical study.

    PubMed

    Khetrapal, Navneet Singh; Jian, Tian; Pal, Rhitankar; Lopez, Gary V; Pande, Seema; Wang, Lai-Sheng; Zeng, Xiao Cheng

    2016-05-05

    Besides the size and structure, compositions can also dramatically affect the properties of alloy nanoclusters. Due to the added degrees of freedom, determination of the global minimum structures for multi-component nanoclusters poses even greater challenges, both experimentally and theoretically. Here we report a systematic and joint experimental/theoretical study of a series of gold-aluminum alloy clusters, AuxAly(-) (x + y = 7,8), with various compositions (x = 1-3; y = 4-7). Well-resolved photoelectron spectra have been obtained for these clusters at different photon energies. Basin-hopping global searches, coupled with density functional theory calculations, are used to identify low-lying structures of the bimetallic clusters. By comparing computed electronic densities of states of the low-lying isomers with the experimental photoelectron spectra, the global minima are determined. It is found that for y ≥ 6 there is a strong tendency to form the magic-number square bi-pyramid motif of Al6(-) in the AuxAly(-) clusters, suggesting that the Al-Al interaction dominates the Au-Au interaction in the mixed clusters. A closely related trend is that for x > 1, the gold atoms tend to be separated by Al atoms unless only the magic-number Al6(-) square bi-pyramid motif is present, suggesting that in the small-sized mixed clusters, Al and Au components do not completely mix with one another. Overall, the Al component appears to play a more dominant role due to the high robustness of the magic-number Al6(-) square bi-pyramid motif, whereas the Au component tends to be either "adsorbed" onto the Al6(-) square bi-pyramid motif if y ≥ 6, or stays away from one another if x < y < 6.

  2. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism?

    PubMed

    Tambi, M I B M; Imran, M K; Henkel, R R

    2012-05-01

    In most countries, millions of people are relying on herbal medicines as remedy for numerous ailments. In South-East Asia, Eurycoma longifolia Jack, also known as 'Malaysian ginseng' or Tongkat ali, is used to combat stress and disease and to improve physical strength. Moreover, the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat. Considering that human studies are not available, 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month. The Ageing Males' Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken. Results show that treatment of LOH patients with this Tongkat ali extract significantly (P < 0.0001) improved the AMS score as well as the serum testosterone concentration. While before treatment only 10.5% of the patients did not show any complaint according to the AMS scale and 35.5% had normal testosterone levels, after the completed treatment 71.7% and 90.8% of the patients showed normal values, respectively. Thus, Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism.

  3. Examination of the "Theory of Guidance" in the View of 'Ali Ibn Abi Talib (A): An Exploration into the Nahj Al-Balaghah

    ERIC Educational Resources Information Center

    Rostami-Nasab, Abas Ali; Tajedini, Oranus; Sadatmoosavi, Ali

    2016-01-01

    This study examines the "Theory of Guidance" according to 'Ali ibn Abi Talib (a). This theory is based on three divine covenants or fundamentals in guidance including the divine Prophet, the divine Book, and the divine human nature ("fitrat"). Research in this regard seems essential because this theory has not been previously…

  4. SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling

    PubMed Central

    Bai, Xiaozhi; Fan, Lei; He, Ting; Jia, Wenbin; Yang, Longlong; Zhang, Jun; Liu, Yang; Shi, Jihong; Su, Linlin; Hu, Dahai

    2015-01-01

    Silent information regulator type-1 (SIRT1) has been reported to be involved in the cardiopulmonary protection. However, its role in the pathogenesis of burn-induced remote acute lung injury (ALI) is currently unknown. The present study aims to investigate the role of SIRT1 in burn-induced remote ALI and the involved signaling pathway. We observed that SIRT1 expression in rat lung tissue after burn injury appeared an increasing trend after a short period of suppression. The upregulation of SIRT1 stimulated by resveratrol exhibited remission of histopathologic changes, reduction of cell apoptosis, and downregulation of pro-inflammatory cytokines in rat pulmonary tissues suffering from severe burn. We next used primary pulmonary microvascular endothelial cells (PMVECs) challenged by burn serum (BS) to simulate in vivo rat lung tissue after burn injury, and found that BS significantly suppressed SIRT1 expression, increased cell apoptosis, and activated p38 MAPK signaling. The use of resveratrol reversed these effects, while knockdown of SIRT1 by shRNA further augmented BS-induced increase of cell apoptosis and activation of p38 MAPK. Taken together, these results indicate that SIRT1 might protect lung tissue against burn-induced remote ALI by attenuating PMVEC apoptosis via p38 MAPK signaling, suggesting its potential therapeutic effects on the treatment of ALI. PMID:25992481

  5. PD-L1 regulates the Tregs’ capacity to repress shock/sepsis induced indirect lung injury (iALI) by recruiting phosphatase SHP-1

    PubMed Central

    Tang, Lunxian; Bai, Jianwen; Chung, Chun-Shiang; Lomas–Neira, Joanne; Chen, Yaping; Huang, Xin; Ayala, Alfred

    2014-01-01

    We recently reported that adoptively transferred (AT) exogenous CD4+CD25+ regulatory T cells (Tregs) to wild type (WT) mice can directly act to repress shock/sepsis induced experimental iALI and this is mediated in part by programmed cell death receptor 1 (PD-1). In this study, we further determine whether recipient mouse lacking PD-L1, one of the primary ligands for PD-1, contributes to the manipulation of the Tregs’ capacity to repress lung injury. To do this, Tregs isolated from the spleen of WT mice were AT into PD-L1−/− mice subjected to hemorrhagic shock [Hem] and subsequent to cecal ligation and puncture (CLP) to induce iALI. Samples were collected for analyses 24 hours after CLP. We found that in PD-L1−/− recipient mice, AT WT-Tregs lost the ability to reverse the development of iALI seen in WT recipient mice (i.e., no reduction of lung injury indices assessed by histology and vascular leakage; failure to decrease the lung neutrophil influx [MPO activity] or the rise in lung apoptosis [caspase 3 activity]). Also a significant increase of interlukin-1β (IL-1β) and keratinocyte-derived chemokine (KC), but no changes in IL-6, IL-10 and IL-17A levels in lung tissues were seen in these mice compared with iALI mice without AT of Tregs. Furthermore, we noted that the lung tissue tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1), but not SHP-2, was activated with the AT of Tregs in PD-L1−/− iALI mice. Finally, through local depletion of CD4+ T cells or CD25+ (Tregs) in the lung, prior to inducing iALI, we found that SHP-1 activation was associated with the loss of Tregs’ protective effects in vivo. Collectively, our data reveal that PD-L1 is a critical modulator of Treg’s ability to suppress iALI and this appears to involve SHP-1 activation. PMID:25057927

  6. Comparative Analysis of EO-1 ALI and Hyperion, and Landsat ETM+ Data for Mapping Forest Crown Closure and Leaf Area Index.

    PubMed

    Pu, Ruiliang; Gong, Peng; Yu, Qian

    2008-06-06

    In this study, a comparative analysis of capabilities of three sensors for mapping forest crown closure (CC) and leaf area index (LAI) was conducted. The three sensors are Hyperspectral Imager (Hyperion) and Advanced Land Imager (ALI) onboard EO-1 satellite and Landsat-7 Enhanced Thematic Mapper Plus (ETM+). A total of 38 mixed coniferous forest CC and 38 LAI measurements were collected at Blodgett Forest Research Station, University of California at Berkeley, USA. The analysis method consists of (1) extracting spectral vegetation indices (VIs), spectral texture information and maximum noise fractions (MNFs), (2) establishing multivariate prediction models, (3) predicting and mapping pixel-based CC and LAI values, and (4) validating the mapped CC and LAI results with field validated photo-interpreted CC and LAI values. The experimental results indicate that the Hyperion data are the most effective for mapping forest CC and LAI (CC mapped accuracy (MA) = 76.0%, LAI MA = 74.7%), followed by ALI data (CC MA = 74.5%, LAI MA = 70.7%), with ETM+ data results being least effective (CC MA = 71.1%, LAI MA = 63.4%). This analysis demonstrates that the Hyperion sensor outperforms the other two sensors: ALI and ETM+. This is because of its high spectral resolution with rich subtle spectral information, of its short-wave infrared data for constructing optimal VIs that are slightly affected by the atmosphere, and of its more available MNFs than the other two sensors to be selected for establishing prediction models. Compared to ETM+ data, ALI data are better for mapping forest CC and LAI due to ALI data with more bands and higher signal-to-noise ratios than those of ETM+ data.

  7. Comparative Analysis of EO-1 ALI and Hyperion, and Landsat ETM+ Data for Mapping Forest Crown Closure and Leaf Area Index

    PubMed Central

    Pu, Ruiliang; Gong, Peng; Yu, Qian

    2008-01-01

    In this study, a comparative analysis of capabilities of three sensors for mapping forest crown closure (CC) and leaf area index (LAI) was conducted. The three sensors are Hyperspectral Imager (Hyperion) and Advanced Land Imager (ALI) onboard EO-1 satellite and Landsat-7 Enhanced Thematic Mapper Plus (ETM+). A total of 38 mixed coniferous forest CC and 38 LAI measurements were collected at Blodgett Forest Research Station, University of California at Berkeley, USA. The analysis method consists of (1) extracting spectral vegetation indices (VIs), spectral texture information and maximum noise fractions (MNFs), (2) establishing multivariate prediction models, (3) predicting and mapping pixel-based CC and LAI values, and (4) validating the mapped CC and LAI results with field validated photo-interpreted CC and LAI values. The experimental results indicate that the Hyperion data are the most effective for mapping forest CC and LAI (CC mapped accuracy (MA) = 76.0%, LAI MA = 74.7%), followed by ALI data (CC MA = 74.5%, LAI MA = 70.7%), with ETM+ data results being least effective (CC MA = 71.1%, LAI MA = 63.4%). This analysis demonstrates that the Hyperion sensor outperforms the other two sensors: ALI and ETM+. This is because of its high spectral resolution with rich subtle spectral information, of its short-wave infrared data for constructing optimal VIs that are slightly affected by the atmosphere, and of its more available MNFs than the other two sensors to be selected for establishing prediction models. Compared to ETM+ data, ALI data are better for mapping forest CC and LAI due to ALI data with more bands and higher signal-to-noise ratios than those of ETM+ data. PMID:27879906

  8. Cross-calibration of MODIS with ETM+ and ALI sensors for long-term monitoring of land surface processes

    USGS Publications Warehouse

    Meyer, D.; Chander, G.

    2006-01-01

    Increasingly, data from multiple sensors are used to gain a more complete understanding of land surface processes at a variety of scales. Although higher-level products (e.g., vegetation cover, albedo, surface temperature) derived from different sensors can be validated independently, the degree to which these sensors and their products can be compared to one another is vastly improved if their relative spectroradiometric responses are known. Most often, sensors are directly calibrated to diffuse solar irradiation or vicariously to ground targets. However, space-based targets are not traceable to metrological standards, and vicarious calibrations are expensive and provide a poor sampling of a sensor's full dynamic range. Crosscalibration of two sensors can augment these methods if certain conditions can be met: (1) the spectral responses are similar, (2) the observations are reasonably concurrent (similar atmospheric & solar illumination conditions), (3) errors due to misregistrations of inhomogeneous surfaces can be minimized (including scale differences), and (4) the viewing geometry is similar (or, some reasonable knowledge of surface bi-directional reflectance distribution functions is available). This study explores the impacts of cross-calibrating sensors when such conditions are met to some degree but not perfectly. In order to constrain the range of conditions at some level, the analysis is limited to sensors where cross-calibration studies have been conducted (Enhanced Thematic Mapper Plus (ETM+) on Landsat-7 (L7), Advance Land Imager (ALI) and Hyperion on Earth Observer-1 (EO-1)) and including systems having somewhat dissimilar geometry, spatial resolution & spectral response characteristics but are still part of the so-called "A.M. constellation" (Moderate Resolution Imaging Spectrometer (MODIS) aboard the Terra platform). Measures for spectral response differences and methods for cross calibrating such sensors are provided in this study. These

  9. Quaternary high-Mg ultrapotassic rocks from the Qal'eh Hasan Ali maars, southeastern Iran: petrogenesis and geodynamic implications

    NASA Astrophysics Data System (ADS)

    Pang, Kwan-Nang; Chung, Sun-Lin; Zarrinkoub, Mohammad Hossein; Wang, Fei; Kamenetsky, Vadim S.; Lee, Hao-Yang

    2015-09-01

    A set of rare, high-Mg ultrapotassic rocks from the Qal'eh Hasan Ali maars, southeastern Iran, was investigated using phlogopite 40Ar/39Ar geochronology, olivine chemistry, and bulk-rock elemental and Sr-Nd-Hf isotopic geochemistry to decipher their petrogenesis and regional tectonic implications. Phlogopite separates yield inverse isochron 40Ar/39Ar ages from ca. 112 to 119 ka, indicating that magma genesis postdated the onset of the Arabia-Eurasia collision at the Late Eocene-Early Oligocene. The studied rocks are characterized by kamafugitic affinity with relatively low SiO2 and Al2O3 and high CaO and Sr. They contain relatively primitive olivine (Fo85-92) that, on the basis of olivine-liquid Fe/Mg exchange equilibrium, suggests the primary melt to be ultrapotassic with ~13 wt% MgO. Other key geochemical features include extreme enrichment in most incompatible trace elements, depletions in Nb, Ta, P and Ti and enrichment in Pb relative to elements of similar incompatibilities. The Sr-Nd-Hf isotopic ratios of the rocks do not deviate significantly from the bulk silicate Earth (87Sr/86Sr = 0.7055-0.7059, 143Nd/144Nd = 0.5125-0.5126 and 176Hf/177Hf = 0.2827-0.2829). Relatively high Zn/Fe, Gd/Yb, Rb, Rb/Sr and P2O5 and low Yb and P/P* for the rocks are consistent with derivation from a mantle source containing clinopyroxene, phlogopite, apatite and garnet that formed in response to modal metasomatism in the lithospheric mantle. Relatively low Hf/Nd and high Sr/Hf of the rocks indicate that the metasomatized lithologies from which the studied rocks formed were derived dominantly from subducted marly sediments. The Qal'eh Hasan Ali magmatism is best explained by small-scale destruction of the continental mantle in a post-collisional setting, presumably driven by localized convective instability as a result of the Arabia-Eurasia collision.

  10. Alis, A State-of-the-Art Optical Observation Network for the Exploration of Polar Atmospheric Processes

    NASA Astrophysics Data System (ADS)

    Aso, T.; Steen, Å.; Brändström, U.; Gustavsson, B.; Urashima, A.; Ejiri, M.

    An optical group at the Swedish Institute of Space Physics in Kiruna, Sweden has been developing the ALIS (Auroral Large Imaging System) multi-station optical observing network which makes it possible to obtain composite monochromatic 2-D images over a fairly wide field-of-view (FOV), and more interestingly, a CT (Computed Tomography) image set for the retrieval of 3-D structure of aurora by adjusting vergence angles of cameras to a common volume. National Institute of Polar Research, Japan is collaborating in observation and analysis. At the moment, the network has 6 stations separated from each other by about 50 km.Each station houses a monochromatic CCD (Charge Coupled Device) imaging system mounted on the steerable azimuth/elevation drive along with a house keeping unit and supervising computer linked to the control center via a telephone line. Altitude profiles of luminosity for stable arc and aurora vortex at 557.7nm and recently at 427.8nm are analysed by the algebraic reconstruction technique and compared with sophisticated numerical modelling of auroral emission rate. Conjunctions with satellites and radars are now intensively explored towards comprehensive understanding of the formation and electrodynamics of aurora. Imaging of polar stratospheric clouds is also attempted in relation to arctic environmental studies

  11. Tongkat Ali as a potential herbal supplement for physically active male and female seniors--a pilot study.

    PubMed

    Henkel, Ralf R; Wang, Ruxiang; Bassett, Susan H; Chen, Tao; Liu, Na; Zhu, Ying; Tambi, Mohd Ismail

    2014-04-01

    Tongkat Ali (Eurycoma longifolia; TA) is known to increase testosterone levels and alleviate aging males' symptoms. This study aimed at investigating TA as an ergogenic supplement for elderly people. Thirteen physically active male and 12 physically active female seniors (57-72 years) were supplemented with 400-mg TA extract daily for 5 weeks. Standard hematological parameters were taken. In addition, the concentrations of total and free testosterone, dihydroepiandrosterone, cortisol, insulin-like growth factor-1, and sex hormone-binding globulin were analyzed. As additional biochemical parameters, blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage, respectively, as well as the muscle strength by a simple handgrip test were determined. After treatment, hemoglobin, testosterone, and dihydroepiandrosterone concentrations, and the ratio of total testosterone/cortisol and muscle force remained significantly lower in female seniors than in male seniors. Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors. Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women. The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations. The study affirms the ergogenic benefit of TA through enhanced muscle strength. Copyright © 2013 John Wiley & Sons, Ltd.

  12. Synthesis of Multispectral Bands from Hyperspectral Data: Validation Based on Images Acquired by AVIRIS, Hyperion, ALI, and ETM+

    NASA Technical Reports Server (NTRS)

    Blonksi, Slawomir; Gasser, Gerald; Russell, Jeffrey; Ryan, Robert; Terrie, Greg; Zanoni, Vicki

    2001-01-01

    Multispectral data requirements for Earth science applications are not always studied rigorously studied before a new remote sensing system is designed. A study of the spatial resolution, spectral bandpasses, and radiometric sensitivity requirements of real-world applications would focus the design onto providing maximum benefits to the end-user community. To support systematic studies of multispectral data requirements, the Applications Research Toolbox (ART) has been developed at NASA's Stennis Space Center. The ART software allows users to create and assess simulated datasets while varying a wide range of system parameters. The simulations are based on data acquired by existing multispectral and hyperspectral instruments. The produced datasets can be further evaluated for specific end-user applications. Spectral synthesis of multispectral images from hyperspectral data is a key part of the ART software. In this process, hyperspectral image cubes are transformed into multispectral imagery without changes in spatial sampling and resolution. The transformation algorithm takes into account spectral responses of both the synthesized, broad, multispectral bands and the utilized, narrow, hyperspectral bands. To validate the spectral synthesis algorithm, simulated multispectral images are compared with images collected near-coincidentally by the Landsat 7 ETM+ and the EO-1 ALI instruments. Hyperspectral images acquired with the airborne AVIRIS instrument and with the Hyperion instrument onboard the EO-1 satellite were used as input data to the presented simulations.

  13. Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats

    PubMed Central

    Yu, Jianbo; Wang, Ying; Li, Zhen; Dong, Shuan; Wang, Dan; Gong, Lirong; Shi, Jia; Zhang, Yuan; Liu, Daquan; Mu, Rui

    2016-01-01

    Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common and important oxidative stress in the lung. Mitochondrial fusion responds to the normal morphology and function of cells and is finely regulated by mitochondrial fusion proteins, such as mitofusin-1 protein (Mfn1), mitofusin-2 protein (Mfn2) and optical atrophy 1 (OPA1). Additionally, Mfn1 has been identified as the most important protein in mitochondrial fusion. Heme oxygenase-1 (HO-1) is a stress-inducible protein that plays a critical role in protecting against oxidative stress. However, whether the protection of HO-1 is related to mitochondrial fusion is still a question. Thus, our in vitro and in vivo experiments aimed to identify the relationship between HO-1 and Mfn1. Here, we used Hemin and ZnPP-IX as treatments in an in vivo experiment. Then, HO-1 and Mfn1 were measured using RT-PCR and Western blotting. Supernatants were analyzed for MDA, SOD, and ROS. Our results implied that HO-1 upregulation suppressed oxidative stress induced by LPS, and the possible mechanism could be associated with Mfn1 and the PI3K/Akt pathway. PMID:27830717

  14. Synthesis of Multispectral Bands from Hyperspectral Data: Validation Based on Images Acquired by AVIRIS, Hyperion, ALI, and ETM+

    NASA Technical Reports Server (NTRS)

    Blonksi, Slawomir; Gasser, Gerald; Russell, Jeffrey; Ryan, Robert; Terrie, Greg; Zanoni, Vicki

    2001-01-01

    Multispectral data requirements for Earth science applications are not always studied rigorously studied before a new remote sensing system is designed. A study of the spatial resolution, spectral bandpasses, and radiometric sensitivity requirements of real-world applications would focus the design onto providing maximum benefits to the end-user community. To support systematic studies of multispectral data requirements, the Applications Research Toolbox (ART) has been developed at NASA's Stennis Space Center. The ART software allows users to create and assess simulated datasets while varying a wide range of system parameters. The simulations are based on data acquired by existing multispectral and hyperspectral instruments. The produced datasets can be further evaluated for specific end-user applications. Spectral synthesis of multispectral images from hyperspectral data is a key part of the ART software. In this process, hyperspectral image cubes are transformed into multispectral imagery without changes in spatial sampling and resolution. The transformation algorithm takes into account spectral responses of both the synthesized, broad, multispectral bands and the utilized, narrow, hyperspectral bands. To validate the spectral synthesis algorithm, simulated multispectral images are compared with images collected near-coincidentally by the Landsat 7 ETM+ and the EO-1 ALI instruments. Hyperspectral images acquired with the airborne AVIRIS instrument and with the Hyperion instrument onboard the EO-1 satellite were used as input data to the presented simulations.

  15. Ab initio thermodynamic and elastic properties of AGaH4 hydrides ( A=Li , Na, K, Rb, and Cs)

    NASA Astrophysics Data System (ADS)

    Herbst, J. F.; Hector, L. G., Jr.; Wolf, W.

    2010-07-01

    Systematic properties of the AGaH4 alkali gallium hydrides ( A=Li , Na, K, Rb, and Cs) are investigated within density functional theory. Seven ground-state crystal structures are identified, with two energetically indistinguishable structures found for both LiGaH4 , whose structure is as yet undetermined experimentally, and CsGaH4 . Born effective charge tensors, static and high-frequency dielectric tensors, and phonon dispersion relations incorporating longitudinal-optical/transverse-optical mode splittings are computed. Our results indicate that LiGaH4 and NaGaH4 have technologically interesting standard enthalpies of formation near -30kJ/mole H2 . We find, however, that LiGaH4 is thermodynamically unstable with respect to both LiGa and LiH, providing a possible explanation for its challenging synthesis. The Born stability criteria are evaluated with the computed elasticity tensor components, Cij . All seven structures are found to be both elastically and vibrationally stable.

  16. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack).

    PubMed

    Li, Ching-Hao; Liao, Jiunn-Wang; Liao, Po-Lin; Huang, Wei-Kuang; Tse, Ling-Shan; Lin, Cheng-Hui; Kang, Jaw-Jou; Cheng, Yu-Wen

    2013-01-01

    Tongkat Ali (Eurycoma longifolia) is an indigenous traditional herb in Southern Asia. Its powdered root has been processed to produce health supplements, but no detailed toxicology report is available. In this study, neither mutagenicity nor clastogenicity was noted, and acute oral LD50 was more than 6 g/kg b.w. After 4-week subacute and 13-week subchronic exposure paradigms (0, 0.6, 1.2, and 2 g/kg b.w./day), adverse effects attributable to test compound were not observed with respect to body weight, hematology, serum biochemistry, urinalysis, macropathology, or histopathology. However, the treatment significantly reduced prothrombin time, partial thromboplastin time, blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphate kinase, lactate dehydrogenase, and cholesterol levels, especially in males (P < 0.05). These changes were judged as pharmacological effects, and they are beneficial to health. The calculated acceptable daily intake (ADI) was up to 1.2 g/adult/day. This information will be useful for product development and safety management.

  17. Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats.

    PubMed

    Ang, H H; Cheang, H S; Yusof, A P

    2000-01-01

    We studied the effects of Eurycoma longifolia Jack, commonly known as Tongkat Ali in Malaysia, on the initiation of sexual performance and the weights of sexual accessories in inexperienced castrated male rats. The doses of 200, 400 and 800 mg/kg body weight, which were extracted from E. longifolia Jack, were orally administered to the rats twice daily for 10 days prior to the tests and continued throughout the test period. Testosterone was used as a positive control after injecting 15 mg/kg daily subcutaneously for 32 days. Results showed that E. longifolia Jack produced a dose-dependent increase in sexual performance of the treated animals, but the E. longifolia Jack groups showed lower sexual performance in mounting, intromission and ejaculation than the testosterone group. Further results also showed that E. longifolia Jack promoted the growth of both ventral prostate and seminal vesicles as compared with the control, but the growth of sexual accessories at 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack was less than that of testosterone treated group. The present study therefore gives further evidence of the folkuse of E. longifolia as an aphrodisiac.

  18. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack)

    PubMed Central

    Liao, Jiunn-Wang; Liao, Po-Lin; Huang, Wei-Kuang; Tse, Ling-Shan; Lin, Cheng-Hui; Kang, Jaw-Jou; Cheng, Yu-Wen

    2013-01-01

    Tongkat Ali (Eurycoma longifolia) is an indigenous traditional herb in Southern Asia. Its powdered root has been processed to produce health supplements, but no detailed toxicology report is available. In this study, neither mutagenicity nor clastogenicity was noted, and acute oral LD50 was more than 6 g/kg b.w. After 4-week subacute and 13-week subchronic exposure paradigms (0, 0.6, 1.2, and 2 g/kg b.w./day), adverse effects attributable to test compound were not observed with respect to body weight, hematology, serum biochemistry, urinalysis, macropathology, or histopathology. However, the treatment significantly reduced prothrombin time, partial thromboplastin time, blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphate kinase, lactate dehydrogenase, and cholesterol levels, especially in males (P < 0.05). These changes were judged as pharmacological effects, and they are beneficial to health. The calculated acceptable daily intake (ADI) was up to 1.2 g/adult/day. This information will be useful for product development and safety management. PMID:24062779

  19. Noise disturbance caused by outdoor activities--a simulated-environment study for Ali Sami Yen Stadium, İstanbul.

    PubMed

    Dal, Zeynep; Akdağ, Neşe Yüğrük

    2011-03-01

    Negative effects of noise on individuals, the inevitable result of urbanization, have become a significant urban problem in our day. Introduction of an approach to the noise problem on an urban-planning scale lightens the burden of measures required to be taken against noise at the stages of regional and developmental planning. Stadiums, which should be also evaluated from the point of noise problem when planning decisions are made on the urban planning scale, may cause very serious problems differing depending on the region they are located in. In this article, various dimensions of the noise problem caused by stadiums have been exemplified by making an assessment on Ali Sami Yen football stadium located in Mecidiyeköy district which is among important residential and commercial centres of İstanbul or Turkey. When the simulation results obtained for ordinary days and match days are evaluated, it has been found out that the people living in the area are exposed to noise levels substantially exceeding the acceptable values. Results of the survey conducted in the area have clearly revealed the existence of noise problem, too.

  20. For the relief of Adrian Rodriguez.

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-02-03

    02/20/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  1. San Antonio v. Rodriguez. Analysis and Projection.

    ERIC Educational Resources Information Center

    McGhehey, M. A.

    In this report, the author analyzes the recent United States Supreme Court decision, compares it with the preceding California case, Serrano vs Priest, and predicts future changes in State school finance systems as a result of this case. The author traces the Court's reasoning for finding that there was no violation of the Equal Protection Clause…

  2. Investigation on the neutral and anionic BxAlyH2 (x + y = 7, 8, 9) clusters using density functional theory combined with photoelectron spectroscopy.

    PubMed

    Ding, Li-Ping; Shao, Peng; Lu, Cheng; Zhang, Fang-Hui; Ding, Lei; Yuan, Tao Li

    2016-08-17

    The structure and bonding nature of neutral and negatively charged BxAlyH2 (x + y = 7, 8, 9) clusters are investigated with the aid of previously published experimental photoelectron spectra combined with the present density functional theory calculations. The comparison between the experimental photoelectron spectra and theoretical simulated spectra helps to identify the ground state structures. The accuracy of the obtained ground state structures is further verified by calculating their adiabatic electron affinities and vertical detachment energies and comparing them against available experimental data. The results show that the structures of BxAlyH2 transform from three-dimensional to planar structures as the number of boron atoms increases. Moreover, boron atoms tend to bind together forming Bn units. The hydrogen atoms prefer to bind with boron atoms rather than aluminum atoms. The analyses of the molecular orbital on the ground state structures further support the abovementioned results.

  3. Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

    PubMed Central

    Poulsen, Lisbeth R.; Hanisch, Susanne; Meffert, Katharina; Buch-Pedersen, Morten J.; Jakobsen, Mia K.; Pomorski, Thomas Günther; Palmgren, Michael G.

    2010-01-01

    Members of the P4 subfamily of P-type ATPases are believed to catalyze flipping of phospholipids across cellular membranes, in this way contributing to vesicle biogenesis in the secretory and endocytic pathways. P4-ATPases form heteromeric complexes with Cdc50-like proteins, and it has been suggested that these act as β-subunits in the P4-ATPase transport machinery. In this work, we investigated the role of Cdc50-like β-subunits of P4-ATPases for targeting and function of P4-ATPase catalytic α-subunits. We show that the Arabidopsis P4-ATPases ALA2 and ALA3 gain functionality when coexpressed with any of three different ALIS Cdc50-like β-subunits. However, the final cellular destination of P4-ATPases as well as their lipid substrate specificity are independent of the nature of the ALIS β-subunit they were allowed to interact with. PMID:20053675

  4. Implementation of the final geometry of the V0A detector for the ALICE experiment in the simulator program AliRoot

    SciTech Connect

    Valencia, L.

    2008-07-02

    The V0A trigger detector of the ALICE experiment is a scintillator hodoscope of 32 channels that has been designed and constructed by the Mexican groups at the Instituto de Fisica de la UNAM and the CINVESTAV.In this work, the final geometry of the constructed detector and its support frame have been implemented using the geometrical modeler of the Root framework in order to be able to simulate the response and trigger performance of the detector with AliRoot.

  5. Exposure to Sodium Dichromate at Qarmat Ali Iraq in 2003: Part 2 -- Evaluation of Army and Contractor Actions Related to Hazardous Industrial Exposure

    DTIC Science & Technology

    2011-09-28

    and/ or medical care for personnel who may have been exposed to sodium dichromate at Qarmat Ali. What We Recommend The exposure of Service members and...provided individuals identified as potentially exposed access to medical surveillance and/ or medical care. In addition, the policy and procedure changes... medical surveillance and/ or medical care. The Secretary referred the request to the Army, who in turn requested the DoD Inspector General include the

  6. Comparative alteration mineral mapping using visible to shortwave infrared (0.4-2.4 μm) Hyperion, ALI, and ASTER imagery

    USGS Publications Warehouse

    Hubbard, B.E.; Crowley, J.K.; Zimbelman, D.R.

    2003-01-01

    Advanced Land Imager (ALI), Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), and Hyperion imaging spectrometer data covering an area in the Central Andes between Volcan Socompa and Salar de Llullaillaco were used to map hydrothermally altered rocks associated with several young volcanic systems. Six ALI channels in the visible and near-infrared wavelength range (0.4-1.0 ??m) were useful for discriminating between ferric-iron alteration minerals based on the spectral shapes of electronic absorption features seen in continuum-removed spectra. Six ASTER channels in the short wavelength infrared (1.0-2.5 ??m) enabled distinctions between clay and sulfate mineral types based on the positions of band minima related to Al-OH vibrational absorption features. Hyperion imagery embedded in the broader image coverage of ALI and ASTER provided essential leverage for calibrating and improving the mapping accuracy of the multispectral data. This capability is especially valuable in remote areas of the earth where available geologic and other ground truth information is limited.

  7. First-principles study of zinc-blende BxAlyIn1-x-yN quaternary alloy: Alchemical mixing approximation approach

    NASA Astrophysics Data System (ADS)

    Bamgbose, M. K.; Adebambo, P. O.; Badmus, B. S.; Dare, E. O.; Akinlami, J. O.; Adebayo, G. A.

    2016-08-01

    Detailed first-principle calculations of properties in zinc blende quaternary alloy BxAlyIn1-x-yN at various concentrations are investigated using density functional theory (DFT) within virtual crystal approximation (VCA) implemented in alchemical mixing approximation. The calculated bandgaps show direct transitions at Γ-Γ and indirect transitions at Γ-X, which are opened by increasing boron concentration. The density of state (DOS) revealed upper valence band (VB1) domination by p-states atoms, while s-states dominate the lower valence band (VB2); also, the DOS shows the contribution of d-states to the conduction band. The first critical point in the dielectric constant ranges between 0.07-4.47 eV and is due to the first threshold optical transitions in the energy bandgap. Calculated static dielectric function (DF) 𝜖1(0) is between 5.15 and 10.35, an indication that small energy bandgaps yield large static DFs. The present results indicate ZB-BxAlyIn1-x-yN alloys are suitable candidates of deep ultraviolet light emitting diodes (LEDs), laser diodes (LDs) and modern solar cell since the concentrations x and y make the bandgap and lattice constant of ZB-BxAlyIn1-x-yN quaternary alloys tunable to desirable values.

  8. Influence of composition on structure, morphology and dielectric properties of BixAlyOz composite films synthesized by atomic layer deposition

    NASA Astrophysics Data System (ADS)

    Qiao, Q.; Jin, L. P.; Li, Y. W.; Li, M. J.; Hu, Z. G.; Chu, J. H.

    2017-04-01

    In this experiment we used atomic layer deposited Bi2O3 and Al2O3 films to fabricate the BixAlyOz nanocomposite films. Bismuth composition was modulated in a series of samples via altering the number of bismuth subsidiary cycles. We discovered that the bismuth composition in atomic percent did not monotonically increase with the rise of the number of bismuth cycles. To explain this unconventional variation trend we proposed a growth mechanism regarding the steric hindrance of Bi(thd)3 and the diffusion of TMA. A single Debye-like relaxation can be determined for the BixAlyOz films with a parallel RC element to reflect it. The change in the dielectric response, such as dielectric constant and ac conductivity, was found to be in agreement with the variation of bismuth concentration. This could be attributed to the effect of 6s2 lone pair electrons in Bi-O dipoles. To further confirm the conductive strength, we estimated the optical band gap (Eg) using plots of (αhν)2 versus hν. The value of Eg would decrease from 5.62 eV to 5.00 eV as the bismuth content rises in the BixAlyOz films.

  9. Nosocomial infections and antibiotic resistance pattern in open-heart surgery patients at Imam Ali Hospital in Kermanshah, Iran.

    PubMed

    Heydarpour, Fatemeh; Rahmani, Youssef; Heydarpour, Behzad; Asadmobini, Atefeh

    2017-01-01

    Background: Patients undergoing open heart surgery have a relatively high risk of acquiring nosocomial infections. The development of antibiotic-resistant infections is associated with prolonged hospital stays and mortalities. Objectives: The present study was conducted to investigate nosocomial infections and the antibiotic resistance pattern in bacteria causing these infections in open heart surgery patients at Imam Ali Hospital in Kermanshah in the west of Iran over a 4-year period from March 2011 to March 2014. Materials and methods: The present cross-sectional study was conducted on 135 cases of nosocomial infection among open heart surgery patients. The demographic characteristics and the risk factors of each case of infection were recorded. The antibiotic susceptibility test was carried out using the Minimum Inhibitory Concentration (MIC) method based on the Clinical and Laboratory Standards Institute (CLSI) protocol. The data collected were then analyzed in SPSS-16. Results: Out of the 6,000 patients who underwent open heart surgery during this 4-year period at the selected hospital, nosocomial infections developed in 135 patients (2.25%), 59.3% of whom were female and 40.7% male. Surgery site infection (SSI), pneumonia (PNEU), urinary tract infection (UTI) and blood stream infection (BSI) affected 52.6%, 37%, 9.6% and 0.8% of the cases, respectively. E.coli, Klebsiella spp. and S. aureus were the most common bacteria causing the nosocomial infections. E. coli was most frequently resistant to imipenem (23.3%) Klebsiella spp. to gentamicin (38.5%) S. aureus to co-trimoxazole (54.2%). Conclusion: SSI had a high prevalence in this study. Further studies should therefore be conducted to examine the risk factors associated with SSI in open heart surgery. Various studies have shown that antibiotic resistance patterns are different in different regions. Finding a definitive treatment therefore requires an antibiogram.

  10. Discharge Against Medical Advice in the Pediatric Wards in Boo-ali Sina Hospital, Sari, Iran 2010

    PubMed Central

    Mohseni Saravi, Benyamin; Reza Zadeh, Esmaeil; Siamian, Hasan; Yahghoobian, Mahboobeh

    2013-01-01

    Introduction: Since children neither comprehended nor contribute to the decision, discharge against medical advice is a challenge of health care systems in the world. Therefore, the current study was designed to determine the rate and causes of discharge against medical advice. Methods: This descriptive cross-sectional study was done by reviewing the medical records by census method. Data was analyzed using SPSS software and x2 statistics was used to determine the relationship between variables. The value of P<0.05 was considered significant. Results: Rate of discharged against medical advice was 108 (2.2%). Mean of age and length of stay were 2.8±4 (SD).3 years old and 3.7±5.4 (SD) days, respectively. Totally, 95 patients (88.7%) had health insurance and 65 (60.2%) patients lived in urban areas. History of psychiatric disease and addiction in 22 (20.6%) of the parents were negative. In addition, 100 (92.3%) patients admitted for medical treatment and the others for surgery. The relationship of the signatory with patients (72.3%) was father. Of 108 patients discharged against medical advice, 20 (12%) were readmitted. The relationship between the day of discharge and discharge against medical advice was significant (ρ =0/03). Conclusion: Rate of discharge against medical advice in Boo-ali hospital is the same as the other studies in the same range. The form which is used for this purpose did not have suitable data elements about description of consequence of such discharge, and it has not shown the real causes of discharge against medical advice. PMID:24554800

  11. Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI.

    PubMed

    Lakshmi, Sowmya P; Reddy, Aravind T; Naik, Meghna U; Naik, Ulhas P; Reddy, Raju C

    2012-11-01

    Transmigration of neutrophils (PMNs) from the vasculature into inflamed tissues, mediated by interactions between PMNs and adhesion molecules on endothelial cells, is an essential aspect of inflammation. The crucial adhesion molecules include junctional adhesion molecule (JAM)-A. Investigation of the role of this molecule in models of inflammatory disease has been limited, however, and results in different disease models have varied. No previous study has addressed JAM-A in lung disease or effects on oxidant stress and proinflammatory cytokines. We use JAM-A knockout mice and blocking antibodies to investigate the role of JAM-A in a murine model of acute lung injury (ALI). With either experimental system, we find that absence of JAM-A activity significantly reduces migration of PMNs into the alveolar space, with a resulting decrease in oxidative stress. However, there is no reduction in whole lung activity of PMN-associated myeloperoxidase, presumably reflecting the histologically observed retention of PMNs in lung tissue. Activity of these retained PMNs may account for our failure to find significant change in markers of lung oxidative stress or cytokine and chemokine levels in plasma, lung, and bronchoalveolar lavage fluid. We likewise see no JAM-A-related changes in markers of capillary permeability or lung injury. A similar lack of congruence between effects on PMN migration and tissue injury has been reported in other disease models and for other adhesion molecules in models of ALI. Our results thus confirm the crucial role of JAM-A in PMN transmigration but demonstrate that transmigration is not essential for other aspects of inflammation or for lung injury in ALI.

  12. Free polaron energy levels in AlyGa1-yN/AlxGa1-xN triangle quantum well structures

    NASA Astrophysics Data System (ADS)

    Pan, Hong Yu; Zhao, Feng Qi

    2017-06-01

    In this work, a variational method is used to examine the problems relevant to the free polaron energy spectrum in a wurtzite AlyGa1-yN/AlxGa1-xN triangle quantum well structure. The numerical calculations for the ground state energy, transition energy and polaron energy shifts as the functions of well-width d and composition x are carried out by considering the anisotropies of the parameters, such as the optical phonon frequency, dielectric constant and electron effective mass, as well as their observed changes with coordinate z in this system. The research results show that the polaron energy shift caused by the electron-optical phonon interaction is large, and leads to an obvious energy decrease in the AlyGa1-yN/AlxGa1-xN triangular quantum well structure. The contribution of the confined phonon is found to increase with the increasing of the well-width and composition x, while that of the half space phonon is observed to decrease with the increasing of the well-width and composition x. The total contribution of the phonon increases with the increasing composition x, while a minimum is found to occur to the total contribution of the phonon during the decreasing process with the well-width. As the d increases, the free polaron energies and transition energies decrease. Meanwhile, with the increasing of the composition x, the energy and transition energy are found to be increased. In the AlyGa1-yN/AlxGa1-xN triangular quantum well structure, the trends of the free polaron energy, transition energy and polaron energy shifts with the well-width and composition x are found to be similar to those in the GaN/AlxGa1-xN square quantum well structure. However, the corresponding values in the triangular quantum well structure are obviously greater than those in the square quantum well structure.

  13. Radiometric cross-calibration of EO-1 ALI with L7 ETM+ and Terra MODIS sensors using near-simultaneous desert observations

    USGS Publications Warehouse

    Chander, Gyanesh; Angal, Amit; Choi, Taeyoung; Xiong, Xiaoxiong

    2013-01-01

    The Earth Observing-1 (EO-1) satellite was launched on November 21, 2000, as part of a one-year technology demonstration mission. The mission was extended because of the value it continued to add to the scientific community. EO-1 has now been operational for more than a decade, providing both multispectral and hyperspectral measurements. As part of the EO-1 mission, the Advanced Land Imager (ALI) sensor demonstrates a potential technological direction for the next generation of Landsat sensors. To evaluate the ALI sensor capabilities as a precursor to the Operational Land Imager (OLI) onboard the Landsat Data Continuity Mission (LDCM, or Landsat 8 after launch), its measured top-of-atmosphere (TOA) reflectances were compared to the well-calibrated Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+) and the Terra Moderate Resolution Imaging Spectroradiometer (MODIS) sensors in the reflective solar bands (RSB). These three satellites operate in a near-polar, sun-synchronous orbit 705 km above the Earth's surface. EO-1 was designed to fly one minute behind L7 and approximately 30 minutes in front of Terra. In this configuration, all the three sensors can view near-identical ground targets with similar atmospheric, solar, and viewing conditions. However, because of the differences in the relative spectral response (RSR), the measured physical quantities can be significantly different while observing the same target. The cross-calibration of ALI with ETM+ and MODIS was performed using near-simultaneous surface observations based on image statistics from areas observed by these sensors over four desert sites (Libya 4, Mauritania 2, Arabia 1, and Sudan 1). The differences in the measured TOA reflectances due to RSR mismatches were compensated by using a spectral band adjustment factor (SBAF), which takes into account the spectral profile of the target and the RSR of each sensor. For this study, the spectral profile of the target comes from the near-simultaneous EO-1

  14. Investigation on the geomorphological characteristics of the Kabutar Ali Chai watershed (NW Iran) and their role in flood production

    NASA Astrophysics Data System (ADS)

    Jananeh, Keristineh

    2016-04-01

    The Kabutar Ali Chai watershed is located in NW Iran, 75 km northwest of Tabriz, on the southern hillsides of Mishow mountains. It occupies an area of 67.46 km2 and the length of the main stream is about 24.5 km. Due to the fact that flooding in this watershed threats the downstream rural areas, an investigation was carried out to extract its geomorphologic characteristics and evaluate their contribution in flood production. In this regard, the watershed area was divided into 4 sections based on physiographic and topographic characteristics and stream network: A1 (the southern, low-height part), A2 (mid-western half), A3 (mid-eastern half) and A4 (the northern and highest part). Hypsometric maps and diagrams prepared for the area show that it is confined between 1390 and 3230m elevation levels with a general dip towards the south. The main part of it (57.93%) is located between the elevation levels of 1390 and 1500m. Using the precipitation records of 4 neighboring stations for 20 years, the estimated time of concentration for the runoff varies in the sub-zones: 1.64 hr in A1 (13.9 km stream length and 710 m altitude difference), 0.63 hr in A2 (7.2 km and 1200 m), 0.35 hr in A3 (4.7 km and 1530 m) and 0.48 hr in A4 (5.9 km and 1330 m.) Dip angle is one of the most important factors affecting the time of concentration for runoff and flood production. The average dip of the main part of the area (79.82%) ranges between 0 and 5°, while only the 0.44% of the area has dips about 30-40°. Highest dips are found in the A4 zone (0-40°) and the weight average dip of the total area is 12.94%. Geologically, the most widespread rocks are Pre-Cambrian shales, schists and limestones (Kahar Formation, 43.53%), upper-Cretaceous flysch sequence comprised of shale, limestone and sandstone (13.99%), Miocene marls, silts, clays and limestones (4.13%) and Quaternary alluvial terraces and plains (30.33%). Geomorphologically, this watershed is comprised of 3 types of lands: (1

  15. Substitution effects on magnetic properties of Mg1.3-xMnxAlyFe1.8-yO4 ferrite

    NASA Astrophysics Data System (ADS)

    Kuo, Ming-Feng; Hung, Yung-Hsiung; Huang, Jing-Yi; Huang, Ching-Chien

    2017-05-01

    Mg1.3-xMnxAlyFe1.8-yO4 (x = 0.1-0.2, y = 0.15-0.3) spinel ferrites were prepared using conventional ceramic technique. Highly densified Mg-Mn-Al ferrites (with 99% theoretical density) were obtained, and the influence of Mn and Al substitution on the characteristics of these ferrites has been systematically studied. The microstructure, magnetic properties, and ferromagnetic resonance linewidth (ΔH) of the Mg-Mn-Al ferrites have been analyzed by X-ray diffraction, B-H analyzer, and ferromagnetic resonance (FMR) spectrometer. The results showed that all of the samples were single spinel phase. As Mn content increases and Al content decreases, both saturation magnetization (4πMs) and squareness ratio increase, while the coercivity (Hc) first increases and then decreases. In addition, good ferromagnetic resonance linewidth properties were also obtained as 143.8 Oe at 9.3 GHz for the sample with x = 0.17 and y = 0.20. The results imply that Mg1.3-xMnxAlyFe1.8-yO4 ferrites may be applicable for X-band (8-12 GHz) microwave devices.

  16. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

    PubMed

    Zhang, Ting; Liu, Yong; Yang, Xianshu; Martin, Gary E; Yao, Huifang; Shang, Jackie; Bugianesi, Randal M; Ellsworth, Kenneth P; Sonatore, Lisa M; Nizner, Peter; Sherer, Edward C; Hill, Susan E; Knemeyer, Ian W; Geissler, Wayne M; Dandliker, Peter J; Helmy, Roy; Wood, Harold B

    2016-03-10

    A potent and selective Factor IXa (FIXa) inhibitor was subjected to a series of liver microsomal incubations, which generated a number of metabolites. Using automated ligand identification system-affinity selection (ALIS-AS) methodology, metabolites in the incubation mixture were prioritized by their binding affinities to the FIXa protein. Microgram quantities of the metabolites of interest were then isolated through microisolation analytical capabilities, and structurally characterized using MicroCryoProbe heteronuclear 2D NMR techniques. The isolated metabolites recovered from the NMR experiments were then submitted directly to an in vitro FIXa enzymatic assay. The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS assay was completely consistent with the enzymatic assay results. This work showcases an innovative and efficient approach to uncover structure-activity relationships (SARs) and guide drug design via microisolation-structural characterization and ALIS capabilities.

  17. A protocol for improving mapping and assessing of seagrass abundance along the West Central Coast of Florida using Landsat TM and EO-1 ALI/Hyperion images

    NASA Astrophysics Data System (ADS)

    Pu, Ruiliang; Bell, Susan

    2013-09-01

    Seagrass habitats are characteristic features of shallow waters worldwide and provide a variety of ecosystem functions. Remote sensing techniques can help collect spatial and temporal information about seagrass resources. In this study, we evaluate a protocol that utilizes image optimization algorithms followed by atmospheric and sunglint corrections to the three satellite sensors [Landsat 5 Thematic Mapper (TM), Earth Observing-1 (EO-1) Advanced Land Imager (ALI) and Hyperion (HYP)] and a fuzzy synthetic evaluation technique to map and assess seagrass abundance in Pinellas County, FL, USA. After image preprocessed with image optimization algorithms and atmospheric and sunglint correction approaches, the three sensors' data were used to classify the submerged aquatic vegetation cover (%SAV cover) into 5 classes with a maximum likelihood classifier. Based on three biological metrics [%SAV, leaf area index (LAI), and Biomass] measured from the field, nine multiple regression models were developed for estimating the three biometrics with spectral variables derived from the three sensors' data. Then, five membership maps were created with the three biometrics along with two environmental factors (water depth and distance-to-shoreline). Finally, seagrass abundance maps were produced by using a fuzzy synthetic evaluation technique and five membership maps. The experimental results indicate that the HYP sensor produced the best results of the 5-class classification of %SAV cover (overall accuracy = 87% and Kappa = 0.83 vs. 82% and 0.77 by ALI and 79% and 0.73 by TM) and better multiple regression models for estimating the three biometrics (R2 = 0.66, 0.62 and 0.61 for %SAV, LAI and Biomass vs. 0.62, 0.61 and 0.55 by ALI and 0.58, 0.56 and 0.52 by TM) for creating seagrass abundance maps along with two environmental factors. Combined our results demonstrate that the image optimization algorithms and the fuzzy synthetic evaluation technique were effective in mapping

  18. Geochemistry of rare earth elements in the Baba Ali magnetite skarn deposit, western Iran - a key to determine conditions of mineralisation

    NASA Astrophysics Data System (ADS)

    Zamanian, Hassan; Radmard, Kaikosrov

    2016-03-01

    The Baba Ali skarn deposit, situated 39 km to the northwest of Hamadan (Iran), is the result of a syenitic pluton that intruded and metamorphosed the diorite host rock. Rare earth element (REE) values in the quartz syenite and diorite range between 35.4 and 560 ppm. Although the distribution pattern of REEs is more and less flat and smooth, light REEs (LREEs) in general show higher concentrations than heavy REEs (HREEs) in different lithounits. The skarn zone reveals the highest REE-enriched pattern, while the ore zone shows the maximum depletion pattern. A comparison of the concentration variations of LREEs (La-Nd), middle REEs (MREEs; Sm-Ho) and HREEs (Er-Lu) of the ore zone samples to the other zones elucidates two important points for the distribution of REEs: 1) the distribution patterns of LREEs and MREEs show a distinct depletion in the ore zone while representing a great enrichment in the skarn facies neighbouring the ore body border and decreasing towards the altered diorite host rock; 2) HREEs show the same pattern, but in the exoskarn do not reveal any distinct increase as observed for LREEs and MREEs. The ratio of La/Y in the Baba Ali skarn ranges from 0.37 to 2.89. The ore zone has the highest La/Y ratio. In this regard the skarn zones exhibit two distinctive portions: 1) one that has La/Y >1 beingadjacent to the ore body and; 2) another one with La/Y < 1 neighbouring altered diorite. Accordingly, the Baba Ali profile, from the quartz syenite to the middle part of the exoskarn, demonstrates chiefly alkaline conditions of formation, with a gradual change to acidic towards the altered diorite host rocks. Utilising three parameters, Ce/Ce*, Eu/Eu* and (Pr/Yb)n, in different minerals implies that the hydrothermal fluids responsible for epidote and garnet were mostly of magmatic origin and for magnetite, actinolite and phlogopite these were of magmatic origin with low REE concentration or meteoric water involved.

  19. Tunable room-temperature zero temperature coefficient of resistivity in antiperovskite compounds Ga1-xCFe3 and Ga1-yAlyCFe3

    NASA Astrophysics Data System (ADS)

    Lin, S.; Wang, B. S.; Lin, J. C.; Huang, Y. N.; Lu, W. J.; Zhao, B. C.; Tong, P.; Song, W. H.; Sun, Y. P.

    2012-07-01

    The effects of the Ga content and the substitution of Al for Ga on the temperature coefficient of resistivity (TCR) of antiperovskite GaCFe3 have been investigated systematically. Our results indicate the value of TCR and its temperature range can be tuned by altering chemical compositions. With decreasing the Ga content in Ga1-xCFe3 or increasing Al dopant in Ga1-yAlyCFe3, the sign of TCR changes from positive to negative and room-temperature zero TCR material can be achieved. Typically, the optimized TCR values are about -5.72 ppm/K(265-315 K) and -14.68 ppm/K(280-320 K) for Ga0.95CFe3 and Ga0.85Al0.15CFe3, respectively. The possible mechanisms for the observed low TCR are discussed.

  20. First-principles study of the magnetic and electronic properties of AMnAs (A=Li, Na, K, Rb, Cs)

    NASA Astrophysics Data System (ADS)

    Zhou, Wenqi; Wu, Shuxiang; Li, Shuwei

    2016-12-01

    Recent studies have demonstrated that antiferromagnetic (AFM) semiconductors are promising alternative materials for spintronic applications. In this work, we report a detailed investigation of the magnetic and electronic properties of AMnAs (A=Li, Na, K, Rb, Cs) using density functional theory. It is found that all studied compounds are ordered antiferromagnetically in the MnAs ab plane, however, along the c axis, NaMnAs is ordered ferromagnetically which is different from the AFM coupling of other materials. These results on magnetic structures are in good agreement with observed facts. Furthermore, our calculations predict that all materials have a semiconducting band structure, which indicates the potential of device applications.

  1. Using a source-to-source transformation to introduce multi-threading into the AliRoot framework for a parallel event reconstruction

    NASA Astrophysics Data System (ADS)

    Lohn, Stefan B.; Dong, Xin; Carminati, Federico

    2012-12-01

    Chip-Multiprocessors are going to support massive parallelism by many additional physical and logical cores. Improving performance can no longer be obtained by increasing clock-frequency because the technical limits are almost reached. Instead, parallel execution must be used to gain performance. Resources like main memory, the cache hierarchy, bandwidth of the memory bus or links between cores and sockets are not going to be improved as fast. Hence, parallelism can only result into performance gains if the memory usage is optimized and the communication between threads is minimized. Besides concurrent programming has become a domain for experts. Implementing multi-threading is error prone and labor-intensive. A full reimplementation of the whole AliRoot source-code is unaffordable. This paper describes the effort to evaluate the adaption of AliRoot to the needs of multi-threading and to provide the capability of parallel processing by using a semi-automatic source-to-source transformation to address the problems as described before and to provide a straight-forward way of parallelization with almost no interference between threads. This makes the approach simple and reduces the required manual changes in the code. In a first step, unconditional thread-safety will be introduced to bring the original sequential and thread unaware source-code into the position of utilizing multi-threading. Afterwards further investigations have to be performed to point out candidates of classes that are useful to share amongst threads. Then in a second step, the transformation has to change the code to share these classes and finally to verify if there are anymore invalid interferences between threads.

  2. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties

    PubMed Central

    Han, Wenjun; Gu, Jingyan; Cheng, Yuanyuan; Liu, Huihui; Li, Yuezhong

    2015-01-01

    Alginate lyases are important tools for oligosaccharide preparation, medical treatment, and energy bioconversion. Numerous alginate lyases have been elucidated. However, relatively little is known about their substrate degradation patterns and product-yielding properties, which is a limit to wider enzymatic applications and further enzyme improvements. Herein, we report the characterization and module truncation of Aly5, the first alginate lyase obtained from the polysaccharide-degrading bacterium Flammeovirga. Aly5 is a 566-amino-acid protein and belongs to a novel branch of the polysaccharide lyase 7 (PL7) superfamily. The protein rAly5 is an endolytic enzyme of alginate and associated oligosaccharides. It prefers guluronate (G) to mannuronate (M). Its smallest substrate is an unsaturated pentasaccharide, and its minimum product is an unsaturated disaccharide. The final alginate digests contain unsaturated oligosaccharides that generally range from disaccharides to heptasaccharides, with the tetrasaccharide fraction constituting the highest mass concentration. The disaccharide products are identified as ΔG units. While interestingly, the tri- and tetrasaccharide fractions each contain higher proportions of ΔG to ΔM ends, the larger final products contain only ΔM ends, which constitute a novel oligosaccharide-yielding property of guluronate lyases. The deletion of the noncatalytic region of Aly5 does not alter its M/G preference but significantly decreases the enzymatic activity and enzyme stability. Notably, the truncated protein accumulates large final oligosaccharide products but yields fewer small final products than Aly5, which are codetermined by its M/G preference to and size enlargement of degradable oligosaccharides. This study provides novel enzymatic properties and catalytic mechanisms of a guluronate lyase for potential uses and improvements. PMID:26519393

  3. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties.

    PubMed

    Han, Wenjun; Gu, Jingyan; Cheng, Yuanyuan; Liu, Huihui; Li, Yuezhong; Li, Fuchuan

    2015-10-30

    Alginate lyases are important tools for oligosaccharide preparation, medical treatment, and energy bioconversion. Numerous alginate lyases have been elucidated. However, relatively little is known about their substrate degradation patterns and product-yielding properties, which is a limit to wider enzymatic applications and further enzyme improvements. Herein, we report the characterization and module truncation of Aly5, the first alginate lyase obtained from the polysaccharide-degrading bacterium Flammeovirga. Aly5 is a 566-amino-acid protein and belongs to a novel branch of the polysaccharide lyase 7 (PL7) superfamily. The protein rAly5 is an endolytic enzyme of alginate and associated oligosaccharides. It prefers guluronate (G) to mannuronate (M). Its smallest substrate is an unsaturated pentasaccharide, and its minimum product is an unsaturated disaccharide. The final alginate digests contain unsaturated oligosaccharides that generally range from disaccharides to heptasaccharides, with the tetrasaccharide fraction constituting the highest mass concentration. The disaccharide products are identified as ΔG units. While interestingly, the tri- and tetrasaccharide fractions each contain higher proportions of ΔG to ΔM ends, the larger final products contain only ΔM ends, which constitute a novel oligosaccharide-yielding property of guluronate lyases. The deletion of the noncatalytic region of Aly5 does not alter its M/G preference but significantly decreases the enzymatic activity and enzyme stability. Notably, the truncated protein accumulates large final oligosaccharide products but yields fewer small final products than Aly5, which are codetermined by its M/G preference to and size enlargement of degradable oligosaccharides. This study provides novel enzymatic properties and catalytic mechanisms of a guluronate lyase for potential uses and improvements.

  4. TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).

    PubMed

    Tang, Mengjie; Tian, Yihao; Li, Doulin; Lv, Jiawei; Li, Qun; Kuang, Changchun; Hu, Pengchao; Wang, Ying; Wang, Jing; Su, Ke; Wei, Lei

    2014-01-01

    Acute lung injury (ALI) is an inflammatory disorder associated with reduced alveolar-capillary barrier function and increased pulmonary vascular permeability. Vasodilator-stimulated phosphoprotein (VASP) is widely associated with all types of modulations of cytoskeleton rearrangement-dependent cellular morphology and function, such as adhesion, shrinkage, and permeability. The present studies were conducted to investigate the effects and mechanisms by which tumor necrosis factor-alpha (TNF-α) increases the tight junction permeability in lung tissue associated with acute lung inflammation. After incubating A549 cells for 24 hours with different concentrations (0-100 ng/mL) of TNF-α, 0.1 to 8 ng/mL TNF-α exhibited no significant effect on cell viability compared with the 0 ng/mL TNF-α group (control group). However, 10 ng/mL and 100 ng/mL TNF-α dramatically inhibited the viability of A549 cells compared with the control group (*p<0.05). Monolayer cell permeability assay results indicated that A549 cells incubated with 10 ng/mL TNF-α for 24 hours displayed significantly increased cell permeability (*p<0.05). Moreover, the inhibition of VASP expression increased the cell permeability (*p<0.05). Pretreating A549 cells with cobalt chloride (to mimic a hypoxia environment) increased protein expression level of hypoxia inducible factor-1α (HIF-1α) (*p<0.05), whereas protein expression level of VASP decreased significantly (*p<0.05). In LPS-induced ALI mice, the concentrations of TNF-α in lung tissues and serum significantly increased at one hour, and the value reached a peak at four hours. Moreover, the Evans Blue absorption value of the mouse lung tissues reached a peak at four hours. The HIF-1α protein expression level in mouse lung tissues increased significantly at four hours and eight hours (**p<0.001), whereas the VASP protein expression level decreased significantly (**p<0.01). Taken together, our data demonstrate that HIF-1α acts downstream of TNF-α to

  5. InxGa1-xAs/AlyGa1-yAs/AlzGa1-zAs asymmetric step quantum-well middle wavelength infrared detectors

    NASA Astrophysics Data System (ADS)

    Wu, W. G.; Chang, K.; Jiang, D. S.; Li, Y. X.; Zheng, H. Z.; Liu, H. C.

    2001-10-01

    InxGa1-xAs/AlyGa1-yAs/AlzGa1-zAs asymmetric step quantum-well middle wavelength (3-5 μm) infrared detectors are fabricated. The components display photovoltaic-type photocurrent response as well as the bias-controlled modulation of the peak wavelength of the main response, which is ascribed to the Stark shifts of the intersubband transitions from the local ground states to the extended first excited states in the quantum wells, at the 3-5.3 μm infrared atmospheric transmission window. The blackbody detectivity (Dbb*) of the detectors reaches to about 1.0×1010cm Hz1/2/W at 77 K under bias of ±7 V. By expanding the electron wave function in terms of normalized plane wave basis within the framework of the effective-mass envelope-function theory, the linear Stark effects of the intersubband transitions between the ground and first excited states in the asymmetric step well are calculated. The obtained results agree well with the corresponding experimental measurements.

  6. Effect of integrated pest management on controlling zoonotic cutaneous leishmaniasis in Emamzadeh Agha Ali Abbas (AS) District, Isfahan province, 2006-2009

    PubMed Central

    Nilforoushzadeh, Mohammad Ali; Shirani-Bidabadi, Leila; Saberi, Sedigheh; Hosseini, Seyed Mohsen; Jaffary, Fariba

    2014-01-01

    Background: Cutaneous leishmaniasis (CL) is still considered as a health problem in the world. Several methods of control in different regions, together with obtaining integrated information on its natural foci, are needed to decrease its prevalence. This study was designed to evaluate the effects of simultaneous interventions on CL control. Materials and Methods: A standard questionnaire was used to identify patients among pilgrims to Emamzadeh Agha Ali Abbas (Isfahan Province, Iran). Subsequently, three methods of controlling the disease, including, spraying residential buildings with Baygon, baiting with zinc phosphide poisons, changing the vegetative cover of the region, improving the environment, and mounting a mesh on all doors and windows of buildings in residential areas were used. The control measures were then evaluated by comparing the number of pilgrims affected by CL after and before the interventions. Results: While 23 pilgrims (1.4%) were affected with CL before the intervention (pretest), five (0.3%) persons were found to have CL after taking control measures. The Chi-square test did not indicate any significant difference in the relative frequency of CL (P = 0.731). Conclusion: The only scientific method for preventing and controlling zoonotic CL (ZCL) is a combination of the control methods (improving the environment and fighting off the disease districts and vectors) together with changing the vegetative cover of the region. Any measure for controlling this disease must be taken and programmed in accordance with the relevant experts’ views, in coordination with the participation of other organizations and the society. PMID:24818102

  7. Ionic ASi2N3 (A=Li, Na, K and Rb) stabilized by the covalent Si-N bonding: First-principles calculations

    NASA Astrophysics Data System (ADS)

    Zhang, Huijun; Ren, Jiadong; Wu, Lailei; Zhang, Jingwu

    2017-01-01

    The structural, elastic and electronic properties of LiSi2N3 and its substitutions by Na, K and Rb were investigated through first-principles computations. The expansion of lattice parameters of ASi2N3 from Li, Na, K to Rb is found to be determined by the bond angle of Si-N1-Si, which suggests a possible way to improve the lithium ionic conductivity by substitutions. ASi2N3 (A=Li, Na, K and Rb) shows the similar elastic behaviors, while the electronic band gap gradually decreases from 5.1 to 3.4 eV from LiSi2N3 to RbSi2N3. Interestingly, the analysis of electronic structure, crystal orbital Hamiltonian populations and Bader charges shows that the covalence of Si-N bonding is critical for the stability of ASi2N3 phase. Among ASi2N3 phases, there is a relatively high ionicity in NaSi2N3; the Si-N bond strength in [Si2N3]- net for KSi2N3 and RbSi2N3 is comparable to LiSi2N3, but stronger than NaSi2N3.

  8. Structural phase stability, electronic structure and mechanical properties of alkali metal hydrides AMH4 (A=Li, Na; M=B, AL)

    NASA Astrophysics Data System (ADS)

    Santhosh, M.; Rajeswarapalanichamy, R.

    2016-01-01

    The structural stability of Alkali metal hydrides AMH4 (A=Li, Na; M=B, Al) is analyzed among the various crystal structures, namely hexagonal (P63mc), tetragonal (P42/nmc), tetragonal (P-421c), tetragonal (I41/a), orthorhombic (Pnma) and monoclinic (P21/c). It is observed that, orthorhombic (Pnma) phase is the most stable structure for LiBH4, monoclinic (P21/c) for LiAlH4, tetragonal (P42/nmc) for NaBH4 and tetragonal (I41/a) for NaAlH4 at normal pressure. Pressure induced structural phase transitions are observed in LiBH4, LiAlH4, NaBH4 and NaAlH4 at the pressures of 4 GPa, 36.1 GPa, 26.5 GPa and 46 GPa respectively. The electronic structure reveals that these metal hydrides are wide band gap insulators. The calculated elastic constants indicate that these metal hydrides are mechanically stable at normal pressure.

  9. Effect of integrated pest management on controlling zoonotic cutaneous leishmaniasis in Emamzadeh Agha Ali Abbas (AS) District, Isfahan province, 2006-2009.

    PubMed

    Nilforoushzadeh, Mohammad Ali; Shirani-Bidabadi, Leila; Saberi, Sedigheh; Hosseini, Seyed Mohsen; Jaffary, Fariba

    2014-01-01

    Cutaneous leishmaniasis (CL) is still considered as a health problem in the world. Several methods of control in different regions, together with obtaining integrated information on its natural foci, are needed to decrease its prevalence. This study was designed to evaluate the effects of simultaneous interventions on CL control. A standard questionnaire was used to identify patients among pilgrims to Emamzadeh Agha Ali Abbas (Isfahan Province, Iran). Subsequently, three methods of controlling the disease, including, spraying residential buildings with Baygon, baiting with zinc phosphide poisons, changing the vegetative cover of the region, improving the environment, and mounting a mesh on all doors and windows of buildings in residential areas were used. The control measures were then evaluated by comparing the number of pilgrims affected by CL after and before the interventions. While 23 pilgrims (1.4%) were affected with CL before the intervention (pretest), five (0.3%) persons were found to have CL after taking control measures. The Chi-square test did not indicate any significant difference in the relative frequency of CL (P = 0.731). The only scientific method for preventing and controlling zoonotic CL (ZCL) is a combination of the control methods (improving the environment and fighting off the disease districts and vectors) together with changing the vegetative cover of the region. Any measure for controlling this disease must be taken and programmed in accordance with the relevant experts' views, in coordination with the participation of other organizations and the society.

  10. Luminescent properties of SrZn2(PO4)2:Tb3+ and its luminescence improvement by incorporating A+ (A=Li, Na, and K)

    NASA Astrophysics Data System (ADS)

    Li, Panlai; Wang, Zhijun; Yang, Zhiping; Guo, Qinglin

    2014-12-01

    A novel green phosphor SrZn2(PO4)2:Tb3+ is synthesized by a high temperature solid-state method, and its luminescent property is investigated. X-ray diffraction patterns of SrZn2(PO4)2:Tb3+ indicate a similarity crystalline phase to SrZn2(PO4)2. SrZn2(PO4)2:Tb3+ shows green emission under 369 nm excitation, and the prominent luminescence in green (544 nm) due to 5D4-7F5 transition of Tb3+. For the 544 nm emission, excitation spectrum has several excitation band from 200 nm to 400 nm. Emission intensity of SrZn2(PO4)2:Tb3+ is influenced by Tb3+ concentration, and concentration quenching effect of Tb3+ in SrZn2(PO4)2 is also observed. With incorporating A+ (A=Li, Na, and K) as compensator charge, the emission intensity of SrZn2(PO4)2:Tb3+ can be obviously enhanced. CIE color coordinates of SrZn2(PO4)2:Tb3+ locate in the green region. The results indicate this phosphor may be a potential application in white LEDs.

  11. Raman scattering of magnetic excitations in Y1-x Prx Ba2Cu3-yAlyO7-δ single crystals

    NASA Astrophysics Data System (ADS)

    Rübhausen, M.; Dieckmann, N.; Bock, A.; Merkt, U.; Widder, W.; Braun, H. F.

    1996-11-01

    Magnetic excitations and their role for the superconductivity in cuprate superconductors have been widely discussed in the literature. Here, we present a study of Y1-x Prx Ba2Cu3-yAlyO7-δ single crystals using Raman spectroscopy in an energy range of 50 10000 cm-1 Raman shift. The high energy range is dominated by a two-magnon scattering process at 3J, where J is the superexchange energy. In the Pr-123 single crystal, we find J = 720 cm-1, a damping of the one-magnon states Γ = 200 cm-1, and a resonance energy of 2.79eV for the two-magnon excitation. The two-magnon peak shows a continuous increase of the one-magnon damping with decreasing x and a nearly constant J across the phase transition to the superconductor. Especially, we find a weak two-magnon peak for a superconductor with a Tc = 86 K.

  12. Crystal structures of hydrates of simple inorganic salts. III. Water-rich aluminium halide hydrates: AlCl3 · 15H2O, AlBr3 · 15H2O, AlI3 · 15H2O, AlI3 · 17H2O and AlBr3 · 9H2O.

    PubMed

    Schmidt, Horst; Hennings, Erik; Voigt, Wolfgang

    2014-09-01

    Water-rich aluminium halide hydrate structures are not known in the literature. The highest known water content per Al atom is nine for the perchlorate and fluoride. The nonahydrate of aluminium bromide, stable pentadecahydrates of aluminium chloride, bromide and iodide, and a metastable heptadecahydrate of the iodide have now been crystallized from low-temperature solutions. The structures of these hydrates were determined and are discussed in terms of the development of cation hydration spheres. The pentadecahydrate of the chloride and bromide are isostructural. In AlI(3) · 15H2O, half of the Al(3+) cations are surrounded by two complete hydration spheres, with six H2O in the primary and 12 in the secondary. For the heptadecahydrate of aluminium iodide, this hydration was found for every Al(3+).

  13. A comparison between HfO2/Al2O3 nano-laminates and ternary HfxAlyO compound as the dielectric material in InGaAs based metal-oxide-semiconductor (MOS) capacitors

    NASA Astrophysics Data System (ADS)

    Krylov, Igor; Pokroy, Boaz; Eizenberg, Moshe; Ritter, Dan

    2016-09-01

    We compare the electrical properties of HfO2/Al2O3 nano-laminates with those of the ternary HfxAlyO compound in metal oxide semiconductor (MOS) capacitors. The dielectrics were deposited by atomic layer deposition on InGaAs. Water, ozone, and oxygen plasma were tested as oxygen precursors, and best results were obtained using water. The total dielectric thickness was kept constant in our experiments. It was found that the effective dielectric constant increased and the leakage current decreased with the number of periods. Best results were obtained for the ternary compound. The effect of the sublayer thicknesses on the electrical properties of the interface was carefully investigated, as well as the role of post-metallization annealing. Possible explanations for the observed trends are provided. We conclude that the ternary HfxAlyO compound is more favorable than the nano-laminates approach for InGaAs based MOS transistor applications.

  14. Mapping tropical dry forest height, foliage height profiles and disturbance type and age with a time series of cloud-cleared Landsat and ALI image mosaics to characterize avian habitat

    Treesearch

    E.H. Helmer; Thomas S. Ruzycki; Jr. Joseph M. Wunderle; Shannon Vogesser; Bonnie Ruefenacht; Charles Kwit; Thomas J. Brandeis; David N. Ewert

    2010-01-01

    Remote sensing of forest vertical structure is possible with lidar data, but lidar is not widely available. Here we map tropical dry forest height (RMSE=0.9 m, R2=0.84, range 0.6–7 m), and we map foliage height profiles, with a time series of Landsat and Advanced Land Imager (ALI) imagery on the island of Eleuthera, The Bahamas, substituting time for vertical canopy...

  15. Use of EO-1 Advanced Land Imager (ALI) multispectral image data and real-time field sampling for water quality mapping in the Hirfanlı Dam Lake, Turkey.

    PubMed

    Kavurmacı, Murat; Ekercin, Semih; Altaş, Levent; Kurmaç, Yakup

    2013-08-01

    This paper focuses on the evaluation of water quality variations in Hirfanlı Water Reservoir, which is one of the most important water resources in Turkey, through EO-1 (Earth Observing-1) Advanced Land Imager (ALI) multispectral data and real-time field sampling. The study was materialized in 20 different sampling points during the overpass of the EO-1 ALI sensor over the study area. A multi-linear regression technique was used to explore the relationships between radiometrically corrected EO-1 ALI image data and water quality parameters: chlorophyll a, turbidity, and suspended solids. The retrieved and verified results show that the measured and estimated values of water quality parameters are in good agreement (R (2) >0.93). The resulting thematic maps derived from EO-1 multispectral data for chlorophyll a, turbidity, and suspended solids show the spatial distribution of the water quality parameters. The results indicate that the reservoir has average nutrient values. Furthermore, chlorophyll a, turbidity, and suspended solids values increased at the upstream reservoir and shallow coast of the Hirfanlı Water Reservoir.

  16. Low-Cost Evaluation of EO-1 Hyperion and ALI for Detection and Biophysical Characterization of Forest Logging in Amazonia (NCC5-481)

    NASA Technical Reports Server (NTRS)

    Asner, Gregory P.; Keller, Michael M.; Silva, Jose Natalino; Zweede, Johan C.; Pereira, Rodrigo, Jr.

    2002-01-01

    quantify both the presence and degree of structural disturbance caused by various logging regimes. Our quantitative assessment of Hyperion hyperspectral and ALI multi-spectral data for the detection and structural characterization of selective logging in Amazonia will benefit from data collected through an ongoing project run by the Tropical Forest Foundation, within which we have developed a study of the canopy and landscape biophysics of conventional and reduced-impact logging. We will add to our base of forest structural information in concert with an EO-1 overpass. Using a photon transport model inversion technique that accounts for non-linear mixing of the four biogeophysical indicators, we will estimate these parameters across a gradient of selective logging intensity provided by conventional and reduced impact logging sites. We will also compare our physical ly-based approach to both conventional (e.g., NDVI) and novel (e.g., SWIR-channel) vegetation indices as well as to linear mixture modeling methods. We will cross-compare these approaches using Hyperion and ALI imagers to determine the strengths and limitations of these two sensors for applications of forest biophysics. This effort will yield the first physical ly-based, quantitative analysis of the detection and intensity of selective logging in Amazonia, comparing hyperspectral and improved multi-spectral approaches as well as inverse modeling, linear mixture modeling, and vegetation index techniques.

  17. Prevalence of resistance to antibiotics according to International Classification of Diseases (ICD-10) in Boo Ali Sina Hospital of Sari, 2011-2012.

    PubMed

    Afshar, Parvaneh; Saravi, Benyamin Mohseni; Nehmati, Ebrahim; Farahabbadi, Ebrahim Bagherian; Yazdanian, Azadeh; Siamian, Hasan; Vahedi, Mohammad

    2013-01-01

    One of the issues in health care delivery system is resistance to antibiotics. Many researches were done to show the causes and antibiotics which was resistance. In most researches the methods of classifying and reporting this resistance were made by researcher, so in this research we examined the International Classification of Diseases 10 the edition (ICD-10). This is a descriptive cross section study; data was collected from laboratory of Boo Ali Sina hospital, during 2011-2012. The check list was designed according the aim of study. Variables were age, bacterial agent, specimen, and antibiotics. The bacteria and resistance were classified with ICD-10. The data were analyzed with SPSS (16) soft ware and the descriptive statistics. Results showed that of the 10198 request for culture and antibiogram, there were 1020(10%) resistance. The specimen were 648 (63.5%) urine, blood 127(12.5%), other secretion 125 (12/3%), sputum 102 (10%), lumbar puncture 8 (0/8%), stool 6 (6/0%) and bone marrow 4 (0.4%). The E coli was the most 413 (40.5%) resistance cause to antibiotics which was coded with B96.2 and the most resistance was to multiple antibiotics 885(86.8%) with the U88 code. The results showed that by using the ICD-10 codes, the study of multiple causes and resistance is possible. The routine usage of coding of the ICD-10 would result to an up to date bank of resistance to antibiotics in every hospitals and useful for physicians, other health care, and health administrations.

  18. Evolution and circulation of type-2 vaccine-derived polioviruses in Nad Ali district of Southern Afghanistan during June 2009-February 2011.

    PubMed

    Sharif, Salmaan; Abbasi, Bilal Haider; Khurshid, Adnan; Alam, Muhammad Masroor; Shaukat, Shahzad; Angez, Mehar; Rana, Muhammad Suleman; Zaidi, Syed Sohail Zahoor

    2014-01-01

    Oral polio vaccine has been used successfully as a powerful tool to control the spread of wild polioviruses throughout the world; however, during replication in under immunized children, some vaccine viruses revert and acquire the neurovirulent phenotypic properties. In this study, we describe the evolution and circulation of Vaccine-Derived Polioviruses (VDPVs) in Helmand province of Afghanistan. We investigated 2646 AFP cases of Afghan children from June 2009-February 2011 and isolated 103 (04%) vaccine viruses, 45(1.7%) wild type polioviruses and six (0.22%) type 2 circulating vaccine-derived polioviruses (cVDPVs). These cVDPVs showed 97.7%-98.2% nucleotide and 98%-98.7% amino acid homology in VP1 region on comparison with Sabin type 2 reference strain. All these cVDPVs had two signature mutations of neurovirulent phenotypes and 12 additional mutations in P1 capsid region that might also have contributed to increase neurovirulence and replication. Phylogenetic analysis revealed that all these viruses were closely related and originated from previously reported Sabin like 2 virus from Pakistan which did not conform to the standard definition of VDPVs at that time. It was also observed that initial OPV dose was administered approximately 9 months prior to the collection of first stool specimen of index case. Our findings support that suboptimal surveillance and low routine immunization coverage have contributed to the emergence and spread of these viruses in Afghanistan. We therefore recommend high quality immunization campaigns not only in affected district Nad Ali but also in the bordering areas between Pakistan and Afghanistan to prevent the spread of cVDPVs.

  19. High-sensitivity supercontinuum-based parallel line-field optical coherence tomography with 1 million A-lines/s (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Barrick, Jessica; Doblas, Ana; Sears, Patrick R.; Ostrowski, Lawrence E.; Oldenburg, Amy L.

    2017-02-01

    While traditional, flying-spot, spectral domain OCT systems can achieve MHz linerates, they are limited by the need for mechanical scanning to produce a B-mode image. Line-field OCT (LF OCT) removes the need for mechanical scanning by simultaneously recording all A-lines on a 2D CMOS sensor. Our LF OCT system operates at the highest A-line rate of any spectral domain (SD) LF OCT system reported to date (1,024,000 A-lines/s). This is comparable with the fastest flying-spot SDOCT system reported. Additionally, all OCT systems face a tradeoff between imaging speed and sensitivity. Long exposure times improve sensitivity but can lead to undesirable motion artifacts. LF OCT has the potential to relax this tradeoff between sensitivity and imaging speed because all A-lines are exposed during the entire frame acquisition time. However, this advantage has not yet been realized due to the loss of power-per-A-line by spreading the illumination light across all A-lines on the sample. Here we use a supercontinuum source to illuminate the sample with 500mW of light in the 605-950 nm wavelength band, effectively providing 480 µW of power-per-A-line, with axial and lateral resolutions of 1.8 µm and 14 µm, respectively. With this system we achieve the highest reported sensitivity (113 dB) of any LF OCT system. We then demonstrate the capability of this system by capturing the rapidly beating cilia of human bronchial-epithelial cells in vitro. The combination of high speed and high sensitivity offered by supercontinuum-based LF SD OCT offers new opportunities for studying cell and tissue dynamics.

  20. Development of Antisense Therapeutic and Imaging Agents to Detect and Suppress Inducible Nitric Oxide Synthase (iNOS) Expression in Acute Lung Injury (ALI)

    NASA Astrophysics Data System (ADS)

    Shen, Yuefei

    This dissertation focuses on the development and investigation of antisense imaging and therapeutic agents, combined with nanotechnology, to detect and suppress inducible nitric oxide synthase (iNOS) expression for the diagnosis and treatment of acute lung injury (ALI). To achieve this goal, several efforts were made. The first effort was the identification and characterization of high binding affinity antisense peptide nucleic acids (PNAs) and shell-crosslinked knedel-like nanoparticle (SCK)-PNA conjugates to the iNOS mRNA. Antisense binding sites on the iNOS mRNA were first mapped by a procedure for rapidly generating a library of antisense accessible sites on native mRNAs (MASL) which involves reverse transcription of whole cell mRNA extracts with a random oligodeoxynucleotide primer followed by mRNA-specific PCR. Antisense PNAs against the antisense accessible sites were accordingly synthesized and characterized. The second effort was the investigation of cationic shell crosslinked knedel-like nanoparticle (cSCK)-mediated siRNA delivery to suppress iNOS expression for the treatment of ALI. siRNA with its unique gene-specific properties could serve as a promising therapeutic agent, however success in this area has been challenged by a lack of efficient biocompatible transfection agents. cSCK with its nanometer size and positive charge previously showed efficient cellular delivery of phosphorothioate ODNs (oligodeoxynucleotides), plasmid DNA and PNA. Herein, cSCK showed good siRNA binding and facilitated efficient siRNA transfection in HeLa, a mouse macrophage cell line and other human cell lines. cSCK led to greater silencing efficiency than Lipofectamine 2000 in HeLa cells as determined by the viability following transfection with cytotoxic and non-cytotoxic siRNAs, as well in 293T and HEK cells, and was comparable in BEAS-2B and MCF10a cells. The third effort was the preparation of an iNOS imaging probe through electrostatic complexation between a radiolabeled

  1. Conformational preferences of DNA following damage by aristolochic acids: Structural and energetic insights into the different mutagenic potential of the ALI and ALII-N(6)-dA adducts.

    PubMed

    Kathuria, Preetleen; Sharma, Purshotam; Abendong, Minette N; Wetmore, Stacey D

    2015-04-21

    Aristolochic acids (AAI and AAII), produced by the Aristolochiaceae family of plants, are classified as group I (human) carcinogens by the International Agency for Research on Cancer. These acids are metabolized in cells to yield aristolactams (ALI and ALII, respectively), which further form bulky adducts with the purine nucleobases. Specifically, the adenine lesions are more persistent in cells and have been associated with chronic renal diseases and related carcinogenesis. To understand the structural basis of the nephrotoxicity induced by AAs, the ALI-N(6)-dA and ALII-N(6)-dA lesions are systematically studied using computational methods. Density functional theory calculations indicate that the aristolactam moiety intrinsically prefers a planar conformation with respect to adenine. Nucleoside and nucleotide models suggest that the anti and syn orientations about the glycosidic bond are isoenergetic for both adducts. Molecular dynamics simulations and free energy calculations reveal that the anti base-displaced intercalated conformation is the most stable conformer for both types of AL-N(6)-dA adducted DNA, which agrees with previous experimental work on the ALII-N(6)-dA adduct and thereby validates our approach. Interestingly, this conformer differs from the dominant conformations adopted by other N6-linked adenine lesions, including those derived from polycyclic aromatic hydrocarbons. Furthermore, the second most stable syn base-displaced intercalated conformation lies closer in energy to the anti base-displaced intercalated conformation for ALI-N(6)-dA compared to ALII-N(6)-dA. This indicates that a mixture of conformations may be detectable for ALI-N(6)-dA in DNA. If this enhanced conformational flexibility of double-stranded DNA persists when bound to a lesion-bypass polymerase, this provides a possible structural explanation for the previously observed greater nephrotoxic potential for the ALI versus ALII-N(6)-dA adduct. In addition, the structural

  2. Diffusion, diffraction des neutrons en temps réel et études réalisées in situ

    NASA Astrophysics Data System (ADS)

    Isnard, O.

    2003-02-01

    La diffusion des neutrons est une technique particulièrement efficace pour l'analyse en temps réel des processus réactionnels dans la matière. La diffraction de neutrons in situ a été développée très tôt sur les sources à haut flux tel que l'Institut Laue Langevin. Ces études nécessitent un flux de neutrons important et un détecteur couvrant un domaine angulaire le plus grand possible. Les neutrons offrent la spécificité d'être très peu absorbés par nombre de matériaux, cette faible absorption fait de la diffusion neutronique un excellent outil pour sonder la matière en volume et de manière non destructive. Cela permet en particulier d'utiliser des environnements d'échantillons complexes tout en conservant un flux raisonnable. La diffusion de neutrons en temps réel est donc très largement utilisée par diverses communautés scientifiques : sciences des matériaux, physiciens, chimistes... L'objet de ce cours est de donner les paramètres importants pour ce type d'étude et d'illustrer le propos à l'aide d'exemples pris dans des domaines scientifiques divers : électrochimie, magnétisme, métallurgie, chimie du solide. Après avoir présenté quelques repères méthodologiques sur les méthodes d'acquisition de données, des exemples montreront le fort potentiel de la diffusion neutronique en temps réel pour l'étude de la matière dans des conditions dynamiques. Enfin, nous donnerons aussi quelques conseils pour la visualisation, le dépouillement et l'analyse de ce type d'expérience. La diffusion des neutrons sur poudre est actuellement très bien adaptée aux études réalisées in situ. Cependant, nous verrons que la faisabilité d'études in situ s'étend à d'autres techniques expérimentales telles que la diffusion des neutrons aux petits angles et même la diffusion sur monocristal qui est en plein renouveau.

  3. Le champ critique de claquage de films d'oxyde de polyphénylène réalisés par voie électrochimique

    NASA Astrophysics Data System (ADS)

    Adohi, B.; Gosse, J. P.; Gosse, B.

    1991-10-01

    The electrical breakdown of thin films of polyphenylene oxide electrochemically deposited on stainless steel plane substrates has been studied. First it was examined the dependence of the medium surrounding the dielectric and the electrodes (nature, hydrostatic pressure) on the breakdown voltage and on its statistical distribution. Between sphere and plane electrodes, it appears that even for pressurified gases, breakdown of the film is caused by the gas breakdown. We have analysed the discharges occurring at atmosphere pressure in the test cell. Breakdown of the film occurred when the electric field due to the charge deposited on its surface was about 230 V/μm. We have also studied self-healing capacitors with PPO as a dielectric, and determined the life-time of this material. On a étudié le claquage électrique de films minces d'oxyde de polyphénylène de quelques microns d'épaisseur déposés par voie électrochimique sur un plan en acier inoxydable. L'étude a d'abord été faite en rampe de tension continue dans la géométrie d'électrodes sphèreplan, en fonction du milieu ambiant liquide ou gazeux. L'influence de la pression sur la rigidité diélectrique du matériau, les distributions statistiques de Weibull et les cratères formés au moment du claquage, dans les différents milieux et dans les deux polarités de l'électrode sphérique montrent que le claquage du matériau est causé par des décharges qui se produisent dans le milieu environnant. A partir de l'analyse quantitative de ces décharges, on propose comme critère de caractérisation de la rupture d'un matériau sounmis aux décharges, le champ créé au moment de la rupture par les charges déposées à sa surface. On a réalisé ensuite des échantillons plans << autocicatrisables >> par dépôt de couches minces d'aluminium (quelques milliers d'Å d'épaisseur) sur le film de PPO. On étudie dans cette configuration la durée de vie du matériau.

  4. Centennial-scale vegetation and climate changes in the Middle Atlas, Morocco: new insights from multi-proxy investigations at Lake Sidi Ali

    NASA Astrophysics Data System (ADS)

    Fletcher, William; Campbell, Jennifer; Joannin, Sebastien; Mischke, Steffen; Zielhofer, Christoph; de Batist, Marc; Mikdad, Abdes

    2016-04-01

    The karstic lakes of the Middle Atlas, Morocco, represent a valuable archive of environmental and climatic change for Northwest Africa. Here we present the results of centennial-scale palynological and charcoal analyses as part of a multiproxy palaeolimnological study of sediment cores from Lake Sidi Ali in the Middle Atlas, Morocco (33° 03 N, 05° 00 W; 2,080 m a.s.l.). Supported by absolute dating including 23 more than twenty AMS 14C dates on pollen concentrates, the record covers the entire Holocene and offers insights into vegetation and climate change at a regionally unprecedented centennial-scale. Pollen assemblages are dominated by steppic herbs, evergreen oaks (Quercus), junipers (Cupressaceae) and Atlantic cedar (Cedrus atlantica). A long-term evolution of the montane vegetation is recorded, reflecting progressive changes in the dominant arboreal taxa and leading to the full establishment of the emblematic cedar forests of the area during the mid-Holocene by 6000 cal BP. Orbital-scale changes in seasonality and growing season moisture availability linked to declining summer insolation are implicated, with a transition from (a) warm, dry summers associated with summer drought tolerant taxa especially evergreen Quercus, high algal productivity in the lake, and high background levels of microcharcoal reflecting distant fire activity during the early Holocene, to (b) cool, relatively humid summers with dominance of montane conifers, declining algal productivity in the lake, and episodic local fire activity during the mid- to late Holocene. Superimposed on the long-term environmental changes are recurrent centennial-scale fluctuations in vegetation composition, reflecting competitive dynamics between the major taxa, initially between steppic and arboreal elements, and later between the major tree taxa. Parallels with hydrological proxies including stable O and C isotopes suggest common responses to climatic drivers (fluctuations in moisture sources and

  5. Petrochemistry of ultrapotassic tephrites and associated cognate plutonic xenoliths with carbonatite affinities from the late Quaternary Qa’le Hasan Ali maars, central Iran

    NASA Astrophysics Data System (ADS)

    Saadat, S.; Stern, C. R.; Moradian, A.

    2014-08-01

    The Quaternary Qa’le Hasan Ali (QHA) maars in central Iran occur at the intersection of the north-south Nayband fault, which defines the western boundary of the Lut micro-continental block, and a system of northwest-southeast faults, subparallel to the Zagros suture zone, that formed during the Arabian-Eurasian collision. These post-collisional maars intrude Eocene volcanic rocks of the Urumieh-Dokhtar magmatic belt, which was generated by the subduction of Neotethys oceanic lithosphere below Iran. The highly potassic, Ti-phlogopite + Mg-rich (Fo89-92) olivine + diopside-augite + aegirine-augite basanite tephrites forming the tuff rims of the QHA maars contain tephrite-coated plutonic xenoliths, some of which are interpreted as co-genetic with the tephrites based on their similar mineralogy and Sr isotopic composition (87Sr/86Sr = 0.70590). Cognate plutonic xenoliths have up to ∼20 vol% calcite, considered to be magmatic calcite because of (1) its grain size, which is similar to feldspars and aegirine-augite pyroxenes in these rocks, (2) the occurrence of fine-grained inclusions of pyroxene and apatite within these calcite grains, and (3) the similarity of the Sr-isotopic composition of this calcite with the other minerals in these rocks. The fact that the magmatic calcite has remained intact and did not volatilize during the transport of these xenoliths to the surface in the hot tephrite magma implies a short transit time, indicating that they are samples of a shallow plutonic complex, as does the presence of anorthoclase in these plutonic xenoliths. Their high modal proportion of magmatic calcite suggests that this shallow plutonic complex has affinities with carbonatites. The magmatic calcite-bearing plutonic xenoliths have high LREE/HREE ratios and contain REE-rich allanite (with up to ∼20 wt% LREE) and britholite (∼60 wt% LREE) that make up ∼3 modal percent of the most calcite-rich samples. Similar to many post-collisional highly potassic rocks

  6. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology.

    PubMed

    Rehman, Shaheed Ur; Choe, Kevin; Yoo, Hye Hyun

    2016-03-10

    Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50) of the alcoholic extract of E. longifolia in mice is between 1500-2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents' identification, determination, further development and most importantly, the

  7. Aptian Paleoclimates and Identification of an OAE1a Equivalent in Shallow Marine Environments of the Southern Tethyan Margin: The Bir Oum Ali Section, Northern Chott Chain, Southern Tunisia

    NASA Astrophysics Data System (ADS)

    Hfaiedh, R.; Godet, A.; Arnaud-Vanneau, A.; Zghal, I.; Arnaud, H.; Ouali, J.

    2015-12-01

    Alternations between siliciclastic, carbonate and evaporitic sedimentary systems, as recorded in the Aptian mixed succession of southern Tunisia, reflect profound paleoceanographic, paleoclimatic and tectonic changes in this area of the southern Tethyan margin. Whereas the early Aptian is interpreted as having been dominated by slightly humid conditions, the onset of a gypsiferous sedimentation near the early to late Aptian boundary is associated with the appearance of palygorskite and sepiolite, which supports the installation of arid conditions in the study area. The evaporitic sedimentation may have also been promoted by the peculiar tectonic setting of the Bir Oum Ali area during the Aptian, where local subsidence may have been tectonically-enhanced in relation to the opening of northern and central Atlantic. Chemostratigraphic (δ13C) correlation of the Bir Oum Ali succession with other peri-Tethyan regions complements biostratigraphic findings, and indicates that a potential expression of the Oceanic Anoxic Event (OAE) 1a may be preserved in this area of Tunisia. Although the characteristic negative spike in δ13C values located at the base of this event is not recognized in the present study, a subsequent, large positive excursion is of similar amplitude and absolute values to those reported from other peri-tethyan regions. This comparison supports the identification of isotopic segments C4 to C7 of the OAE1a, during which the dominance of macroalgae over other benthic organisms is observed at Bir Oum Ali. The absence of the negative spike may be linked to either non preservation or non deposition: the OAE1a occurred in a global transgressive context, and since the study area was located in the innermost part of the southern Tethyan margin during most of the Aptian, stratigraphic hiatuses may have been longer than in other regions of the Tethys.

  8. The Rodriguez Decision and the Politics of School Finance

    ERIC Educational Resources Information Center

    van Geel, Tyll

    1973-01-01

    The court refused to declare differences in per pupil district expenditures unconstitutional. Reformers must now look to the State courts for change in the present system of school finance. (Author/WM)

  9. Palaeomagnetism and K-Ar and 40Ar/39Ar ages in the Ali Sabieh area (Republic of Djibouti and Ethiopia): constraints on the mechanism of Aden ridge propagation into southeastern Afar during the last 10 Myr

    NASA Astrophysics Data System (ADS)

    Audin, L.; Quidelleur, X.; Coulié, E.; Courtillot, V.; Gilder, S.; Manighetti, I.; Gillot, P.-Y.; Tapponnier, P.; Kidane, T.

    2004-07-01

    A new detailed palaeomagnetic study of Tertiary volcanics, including extensive K-Ar and 40Ar/39Ar dating, helps constrain the deformation mechanisms related to the opening processes of the Afar depression (Ethiopia and Djibouti). Much of the Afar depression is bounded by 30 Myr old flood basalts and floored by the ca 2 Myr old Stratoid basalts, and evidence for pre-2 Ma deformation processes is accessible only on its borders. K-Ar and 40Ar/39Ar dating of several mineral phases from rhyolitic samples from the Ali Sabieh block shows indistinguishable ages around 20 Myr. These ages can be linked to separation of this block in relation to continental breakup. Different amounts of rotation are found to the north and south of the Holhol fault zone, which cuts across the northern part of the Ali Sabieh block. The southern domain did not record any rotation for the last 8 Myr, whereas the northern domain experienced approximately 12 +/- 9° of clockwise rotation. We propose to link this rotation to the counter-clockwise rotation observed in the Danakil block since 7 Ma. This provides new constraints on the early phases of rifting and opening of the southern Afar depression in connection with the propagation of the Aden ridge. A kinematic model of propagation and transfer of extension within southern Afar is proposed, with particular emphasis on the previously poorly-known period from 10 to 4 Ma.

  10. Luminescent properties of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} and its luminescence improvement by incorporating A{sup +} (A=Li, Na, and K)

    SciTech Connect

    Li, Panlai Wang, Zhijun Yang, Zhiping; Guo, Qinglin

    2014-12-15

    A novel green phosphor SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} is synthesized by a high temperature solid-state method, and its luminescent property is investigated. X-ray diffraction patterns of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} indicate a similarity crystalline phase to SrZn{sub 2}(PO{sub 4}){sub 2}. SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} shows green emission under 369 nm excitation, and the prominent luminescence in green (544 nm) due to {sup 5}D{sub 4}–{sup 7}F{sub 5} transition of Tb{sup 3+}. For the 544 nm emission, excitation spectrum has several excitation band from 200 nm to 400 nm. Emission intensity of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} is influenced by Tb{sup 3+} concentration, and concentration quenching effect of Tb{sup 3+} in SrZn{sub 2}(PO{sub 4}){sub 2} is also observed. With incorporating A{sup +} (A=Li, Na, and K) as compensator charge, the emission intensity of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can be obviously enhanced. CIE color coordinates of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} locate in the green region. The results indicate this phosphor may be a potential application in white LEDs. - Graphical abstract: SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can produce green emission under near-UV excitation, and its luminescent properties can be improved by incorporating A{sup +} (A=Li, Na, and K). - Highlights: • SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can produce green emission under near-UV excitation. • Concentration quenching effect of Tb{sup 3+} in SrZn{sub 2}(PO{sub 4}){sub 2} is observed. • Emission intensities of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} are enhanced by codoped A{sup +} (A=Li, Na, K)

  11. Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.

    PubMed

    2016-10-01

    The above article, published online on June 21, 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figure 5A to be inappropriately manipulated. Literature Cited Ali S, Banerjee S, Logna F, Bao B, Philip PA, Korc M, Sarkar FH. 2012. Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer. J Cell Physiol 227:3373-3380; doi: 10.1002/jcp.24036.

  12. Retraction: "Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer" by Ali et al.

    PubMed

    2016-08-01

    The above article, published online on March 8, 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figures 2A, 4, 6A, and 6C to be inappropriately manipulated. REFERENCE Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA, Sarkar FH. 2010. Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J Cell Biochem 110:171-181; doi: 10.1002/jcb.22523.

  13. Characterization and Electrochemical Performance of SubstitutedLiNi0.4Co0.2-yAlyMn0.4O2 (0<_y<_0.2) Cathode Materials

    SciTech Connect

    Wilcox, James D.; Doeff, Marca M.

    2007-11-28

    A complete series of LiNi0.4Co0.2-yAlyMn0.4O2 (0<_y<_0.2) materials have been synthesized and investigated as cathode materials for lithium ion batteries. When cycled between 2.0 and 4.3 V vs. Li/Li+ at a current density of 0.1 mA/cm2, stable capacities of ~;;160 mAh/g for y=0 to ~;;110 mAh/g for y=0.2 are achieved. Upon increasing the current density, it is found that all materials containing aluminum show reduced polarization and improved rate performance. The optimal performance at all current densities was found for the compound with y=0.05. The effect of aluminumsubstitution on the crystal structure of the host is discussed.

  14. Native-oxide-masked Si impurity-induced layer disordering of AlxGa1 - xAs-AlyGa1 - yAs-AlzGa1 - zAs quantum-well heterostructures

    NASA Astrophysics Data System (ADS)

    El-Zein, N.; Holonyak, N., Jr.; Kish, F. A.; Sugg, A. R.; Richard, T. A.; Dallesasse, J. M.; Smith, S. C.; Burnham, R. D.

    1991-08-01

    Data are presented showing that the native oxide that can be formed on high Al composition AlxGa1-xAs (x≳0.7) confining layers commonly employed on AlxGa1-xAs-AlyGa1-yAs-AlzGa1-zAs (y≳z) superlattices or quantum-well heterostructures serves as an effective mask against Si diffusion, and thus impurity-induced layer disordering. The high-quality native oxide is produced by the conversion of high-composition AlxGa1-xAs (x≳0.7) confining layers via H2O vapor oxidation (≳400 °C) in N2 carrier gas.

  15. Application of multivariate statistical analysis and hydrochemical and isotopic investigations for evaluation of groundwater quality and its suitability for drinking and agriculture purposes: case of Oum Ali-Thelepte aquifer, central Tunisia.

    PubMed

    Hassen, Imen; Hamzaoui-Azaza, Fadoua; Bouhlila, Rachida

    2016-03-01

    Groundwater plays a dominant role in arid regions; it is among the most available water resources in Tunisia. Located in northwestern Tunisia, Oum Ali-Thelepte is a deep Miocene sedimentary aquifer, where groundwater is the most important source of water supply. The aim of the study is to investigate the hydrochemical processes leading to mineralization and to assess water quality with respect to agriculture and drinking for a better management of groundwater resources. To achieve such objectives, water analysis was carried out on 16 groundwater samples collected during January-February 2014. Stable isotopes and 26 hydrochemical parameters were examined. The interpretation of these analytical data showed that the concentrations of major and trace elements were within the permissible level for human use. The distribution of mineral processes in this aquifer was identified using conventional classification techniques, suggesting that the water facies gradually changes from Ca-HCO3 to Mg-SO4 type and are controlled by water-rock interaction. These results were endorsed using multivariate statistical methods such as principal component analysis and cluster analysis. The sustainability of groundwater for drinking and irrigation was assessed based on the water quality index (WQI) and on Wilcox and Richards's diagrams. This aquifer has been classified as "excellent water" serving good irrigation in the area. As for the stable isotope, the measurements showed that groundwater samples lay between global meteoric water line (GMWL) and LMWL; hence, this arrangement signifies that the recharge of the Oum Ali-Thelepte aquifer is ensured by rainwater infiltration through mountains in the border of the aquifer without evaporation effects.

  16. Understanding band alignments in semiconductor heterostructures: Composition dependence and type-I-type-II transition of natural band offsets in nonpolar zinc-blende AlxGa1 -xN /AlyGa1 -yN composites

    NASA Astrophysics Data System (ADS)

    Landmann, M.; Rauls, E.; Schmidt, W. G.

    2017-04-01

    The composition dependence of the natural band alignment at nonpolar AlxGa1 -xN /AlyGa1 -yN heterojunctions is investigated via hybrid functional based density functional theory. Accurate band-gap data are provided using Heyd-Scuseria-Ernzerhof (HSE) type hybrid functionals with a composition dependent exact-exchange contribution. The unstrained band alignment between zincblende (zb) AlxGa1 -xN semiconductor alloys is studied within the entire ternary composition range utilizing the Branch-point technique to align the energy levels related to the bulklike direct Γv→Γc and indirect, pseudodirect, respectively, Γv→Xc type transitions in zb-AlxGa1 -xN . While the zb-GaN/AlxGa1 -xN band edges consistently show a type-I alignment, the relative position of fundamental band edges changes to a type-II alignment in the Al-rich composition ranges of zb-AlxGa1 -xN /AlN and zb-AlxGa1 -xN /AlyGa1 -yN systems. The presence of a direct-indirect band-gap transition at xc=0.63 in zb-AlxGa1 -xN semiconductor alloys gives rise to a notably different composition dependence of band discontinuities in the direct and indirect energy-gap ranges. Below the critical direct-indirect Al/Ga-crossover concentration, the band offsets show a close to linear dependence on the alloy composition. In contrast, notable bowing characteristics of all band discontinuities are observed above the critical crossover composition.

  17. Le diagnostic anténatal de la trisomie 21 par l'hybridation in situ en fluorescence (FISH): à propos des premiers tests réalisés au Maroc

    PubMed Central

    Lamzouri, Afaf; Natiq, Abdelhafid; Tajir, Mariam; Sendid, Mohamed; Sefiani, Abdelaziz

    2012-01-01

    Introduction Le but de cette étude était de présenter les premiers résultats de diagnostic anténatal de la trisomie 21 par la technique d'hybridation in situ en fluorescence (FISH) au Maroc et discuter son intérêt dans le diagnostic rapide de cette aneuploïdie. Méthodes Ce travail a été réalisé chez 23 femmes avec des grossesses à haut risque de trisomie 21. La moyenne d’âge des gestantes étaient de 37,43 ans avec des extrêmes de 21 et 43 ans. Toutes étaient musulmanes mariées, mariage légitimé par la Charia, dont trois mariages consanguins, sauf une originaire de la République Démocratique du Congo qui était chrétienne et concubine. La majorité des femmes étaient fonctionnaires et avaient un niveau de scolarisation moyen à élevé. Toutes les patientes ont bénéficié d'une consultation de génétique médicale au cours de laquelle il leur a été donné des informations sur la technique, son intérêt et ses limites. Il s'agit de femmes enceintes qui avaient soit un âge maternel élevé ou des signes d'appel échographiques et/ ou biochimiques. Une des patientes était porteuse d'une translocation robertsonienne t(14;21) équilibrée. Une amniocentèse a été réalisée chez toutes les gestantes et aucun avortement n'a était induit par ce geste invasif. L’âge gestationnel moyen à la première consultation était de 14 semaines d'aménorrhée (SA) et à l'amniocentèse était de 16 SA et 5 jours. L'analyse FISH a été réalisée, après consentement des couples, sur des cellules non cultivées à partir des échantillons de liquides amniotiques, en utilisant des sondes spécifiques du chromosome 21. Résultats Parmi les 23 patientes qui ont bénéficiées d'un diagnostic anténatal de la trisomie 21 par la technique FISH, nous avons pu rassurer 21 d'entre elles, et nous avons détecté deux cas de trisomie 21 fœtal. Conclusion La technique FISH permet un diagnostic anténatal rapide, en moins de 48h, de la trisomie 21 sur

  18. Crystal structure and ionic conductivity of ruthenium diphosphate ARu{sub 2}(P{sub 2}O{sub 7}){sub 2}, A=Li, Na, and Ag, with a tunnel structure

    SciTech Connect

    Fukuoka, Hiroshi; Matsunaga, Hideyuki; Yamanaka, Shoji

    2003-05-26

    Crystal structure and ionic conductivity of ruthenium diphosphates, ARu{sub 2}(P{sub 2}O{sub 7}){sub 2} A=Li, Na, and Ag, were investigated. The structure of the Ag compound was determined by single crystal X-ray diffraction techniques. It crystallized in the triclinic space group P-1 with a=4.759(2) A, b=6.843(2) A, c=8.063(1) A, {alpha}=90.44(2) deg., {beta}=92.80(2) deg., {gamma}=104.88(2) deg., V=253.4(1) A{sup 3}. The host structure of it was composed of RuO{sub 6} and P{sub 2}O{sub 7} groups and formed tunnels running along the a-axis, in which Ag{sup +} ions were situated. The ionic conductivities have been measured on pellets of the polycrystalline powders. The Li and Ag compounds showed the conductivities of 1.0x10{sup -4} and 3.5x10{sup -5} S cm{sup -1} at 150 deg. C, respectively. Magnetic susceptibility measurement of the Ag compound showed that it did not obey the Curie-Weiss law and the effective magnetic moment decreased as temperature decreased due to the large spin-orbital coupling effect of Ru{sup 4+} ions.

  19. Hydrothermal synthesis, structures and optical properties of A2Zn3(SeO3)4·XH2O (A=Li, Na, K; X=2 or 0)

    NASA Astrophysics Data System (ADS)

    Liu, Yunsheng; Mei, Dajiang; Xu, Jingli; Wu, Yuandong

    2015-12-01

    New alkali metal zinc selenites, A2Zn3(SeO3)4·XH2O (A=Li, Na, K; X=2 or 0) were prepared through hydrothermal reactions. Li2Zn3(SeO3)4·2H2O (1) crystallizes in the monoclinic space group P21/c with lattice parameters a=8.123(4), b=9.139(4), c=7.938(3) Å, β=112.838(9)°. Na2Zn3(SeO3)4·2H2O (2) crystallizes in the monoclinic space group C2/c with lattice parameters a=15.7940(18), b=6.5744(8), c=14.6787(17) Å, β=107.396(3)°. K2Zn3(SeO3)4 (3) crystallizes in the monoclinic space group C2/c with lattice parameters a=11.3584(12), b=8.6091(9), c=13.6816(14) Å, β=93.456(2)°. The anionic structures are composed of [Zn3O12]18- sheets, chains, and "isolated" units in compound 1, 2, 3, respectively, and trigonal pyramids SeO32-. The compounds were characterized by the solid state UV-vis-NIR diffuse reflectance spectroscopy, infrared spectra and thermogravimetric analysis.

  20. Cross-calibration of the Terra MODIS, Landsat 7 ETM+ and EO-1 ALI sensors using near-simultaneous surface observation over the Railroad Valley Playa, Nevada, test site

    USGS Publications Warehouse

    Chander, G.; Angal, A.; Choi, T.; Meyer, D.J.; Xiong, X.; Teillet, P.M.

    2007-01-01

    A cross-calibration methodology has been developed using coincident image pairs from the Terra Moderate Resolution Imaging Spectroradiometer (MODIS), the Landsat 7 (L7) Enhanced Thematic Mapper Plus (ETM+) and the Earth Observing EO-1 Advanced Land Imager (ALI) to verify the absolute radiometric calibration accuracy of these sensors with respect to each other. To quantify the effects due to different spectral responses, the Relative Spectral Responses (RSR) of these sensors were studied and compared by developing a set of "figures-of-merit." Seven cloud-free scenes collected over the Railroad Valley Playa, Nevada (RVPN), test site were used to conduct the cross-calibration study. This cross-calibration approach was based on image statistics from near-simultaneous observations made by different satellite sensors. Homogeneous regions of interest (ROI) were selected in the image pairs, and the mean target statistics were converted to absolute units of at-sensor reflectance. Using these reflectances, a set of cross-calibration equations were developed giving a relative gain and bias between the sensor pair.

  1. In-situ studies on the micro-structure evolution of A2W2O7 (A=Li, Na, K) during melting by high temperature Raman spectroscopy and density functional theory.

    PubMed

    Wang, Jian; You, Jinglin; Wang, Min; Lu, Liming; Wan, Songming; Sobol, A A

    2017-10-05

    In-situ high temperature Raman spectroscopic (HTRS) technique in combination with density functional theory (DFT) analysis has been adopted to investigate the micro-structure of solid and molten A2W2O7 (A=Li, Na, K). The [WO6] octahedra were found to be connected to each other by corner and edge sharing in the crystalline Li2W2O7 and K2W2O7 compounds. In the crystal lattice of Na2W2O7, on the other hand, the [WO4] tetrahedra and [WO6] octahedra were found to coexist and paired by corner sharing. Although the structural diversity has clearly led to distinct Raman spectra of the crystalline A2W2O7 compounds, the spectra of their melts tended to be analogous, showing the typical vibration modes of (W2O7)(2-) dimer. A mechanism was then proposed to explain the structure evolution occurring during the melting process of A2W2O7. The effect of A(+) cation on the Raman bands of (W2O7)(2-) dimer in molten A2W2O7 has also been investigated. Both the wavenumber and full width at half-height (FWHH) of the characteristic band assigned to the symmetrical stretching vibration mode of WOnb (non-bridging oxygen) in (W2O7)(2-) were found to decrease in the sequence of Li(+), Na(+) and K(+), indicating the cation effect on the mean bond length and its distribution range of WOnb. In addition, the relative intensity of this band was also influenced by the cation and it was increased in the order of Li2W2O7, Na2W2O7 and K2W2O7, which has been explained by the charge transfer process and confirmed by Mulliken overlap population analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Electronic properties and structural phase transition in A4 [M4O4] (A=Li, Na, K and Rb; M=Ag and Cu): A first principles study

    NASA Astrophysics Data System (ADS)

    Umamaheswari, R.; Yogeswari, M.; Kalpana, G.

    2013-02-01

    Self-consistent scalar relativistic band structure calculations for AMO (A=Li, Na, K and Rb; M=Ag and Cu) compounds have been performed using the tight-binding linear muffin-tin orbital (TB-LMTO) method within the local density approximation (LDA). At ambient conditions, these compounds are found to crystallize in tetragonal KAgO-type structure with two different space group I-4m2 and I4/mmm. Nowadays, hypothetical structures are being considered to look for new functional materials. AMO compounds have stoichiometry similar to eight-electron half-Heusler materials of type I-I-VI which crystallizes in cubic (C1b) MgAgAs-type structure with space group F-43m. For all these compounds, by interchanging the positions of atoms in the hypothetical cubic structure, three phases (α, β and γ) are formed. The energy-volume relation for these compounds in tetragonal KAgO-type structure and cubic α, β and γ phases of related structure have been obtained. Under ambient conditions these compounds are more stable in tetragonal KAgO-type (I4/mmm) structure. The total energies calculated within the atomic sphere approximation (ASA) were used to determine the ground state properties such as equilibrium lattice parameters, c/a ratio, bulk modulus, cohesive energy and are compared with the available experimental results. The results of the electronic band structure calculations at ambient condition show that LiCuO and NaMO are indirect band gap semiconductors whereas KMO and RbMO are direct band gap semiconductors. At high pressure the band gap decreases and the phenomenon of band overlap metallization occur. Also these compounds undergo structural phase transition from tetragonal I-4m2 phase to cubic α-phase and transition pressures were calculated.

  3. Participation du patient Marocain atteint du cancer au choix thérapeutique: résultat d'une enquête réalisée auprès de 272 patient

    PubMed Central

    Boukir, Anwar; Azghari, Ilham; El Kabous, Mustapha; Jouid, Khalid; Boutayeb, Saber; El Ghissassi, Ibrahim; Mrabti, Hind; Errrihani, Hassan

    2015-01-01

    Introduction La décision médicale partagée ‘Shared decision making’ est un concept qui se développe depuis les années 1990. Il donne aux patients le soutien nécessaire pour exprimer leurs préférences et partager la décision médicale. Cette étude cherche à estimer le degré de participation du patient Marocain atteint de cancer au choix thérapeutique. Méthodes Cette enquête a été réalisée auprès de 272 malades sous chimiothérapie pour une pathologie cancéreuse sous forme d'un entretien verbal basé sur un questionnaire. Les patients ont été sélectionnés selon un mode d’échantillonnage aléatoire, le nombre de patients a été choisi pour une marge d'erreur de 5% et un seuil de probabilité qui approxime les 90%. Résultats Seulement 5.5% des patients dans l'enquête ont participé activement dans le choix thérapeutique. Pour 94% des patients de l’échantillon la stratégie thérapeutique adoptée par le médecin est la bonne et représente l'option optimale. Les principales causes retrouvées qui expliquent la non participation à la décision thérapeutique sont le bas niveau d'instruction, la non réceptivité à l'information ainsi que des défauts majeures dans la transmission et la perception de l'information. Conclusion Ces résultats prouvent que la relation médecin malade dans notre contexte baigne toujours dans le modèle paternaliste. La responsabilité de la décision thérapeutique est le plus souvent laissée au médecin. Il est nécessaire d'informer et d'impliquer le patient de façon active dans le choix thérapeutique afin de mieux sauvegarder la relation médecin-malade qui doit être fondée sur la confiance ainsi que sur une approche participative. PMID:26918070

  4. Résultats de la chirurgie avancée de la cataracte par tunnélisation: à propos de 262 cas réalisés au CHR de Banfora (Burkina Faso)

    PubMed Central

    Djiguimdé, Pierre Windinmanégdé; Diomandé, Ibrahim Abib; Ahnoux-Zabsonré, Ahgbatouhabéba; Koffi, Konan Virgile; Meda, Tierinyê Armand; Diomandé, Gossé François; Sanou, Jerôme; Meda-Hien, Gertude; Sankara, Paté; Meda, Nonfounikoun

    2015-01-01

    La cataracte demeure la première cause de cécité dans les pays en voie de développement posant un problème de santé publique. Le but de cette étude est de faire le bilan d'une activité de chirurgie avancée de la cataracte par la technique dite de « phacoalternative » ou par tunnélisation. Il s'agissait d'une étude prospective de base réalisée au Burkina Faso portant sur la chirurgie de la cataracte par la technique de tunnélisation. L’âge moyen de nos patients atteints de cataracte était de 62,47 ± 12,77 ans avec un sex-ratio de 0,98. La majorité des patients opérés (82,82%) étaient des cultivateurs et des ménagères. L'acuité visuelle de loin était réduite à la perception lumineuse dans 68,70% des cas. La profondeur moyenne de la chambre antérieure était de 2,98 ± 0,53 mm. L’épaisseur moyenne du cristallin était de 3,55 ± 0,75 mm. La longueur axiale moyenne de l’œil de nos patients opérés de la cataracte était de 22,88 ± 0,90 mm. La puissance réfractive moyenne estimée de la cornée était de 43,21 ± 2,03 dioptries chez nos patients. La puissance moyenne estimée de l'implant intra oculaire (IOL) utilisé était de23,11 ± 2,35D. La majorité (79,6%) de nos patients avait une bonne acuité visuelle après la chirurgie de la cataracte par tunnélisation. La chirurgie de la cataracte par tunnélisation est une technique révolutionnaire adaptée aux pays pauvres d'Afrique. Elle permet une lutte efficace à moindre coût contre la cécité par cataracte dans nos régions. La tunnélisation est une technique chirurgicale adaptée pour lutter efficacement contre la cécité due à la cataracte en Afrique. PMID:27022426

  5. Pratique de la prophylaxie de la maladie thromboembolique veineuse: enquête réalisée auprès des professionnels de santé de la ville de Ouagadougou

    PubMed Central

    Naibe, Dangwe Temoua; Samadoulougou, André; Kabore, Hervé; Yameogo, Relwendé Aristide; Millogo, Georges; Yameogo, Nobila Valentin; Kologo, Jonas Koudougou; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2014-01-01

    Introduction L'impact clinique et l'incidence de la maladie thromboembolique veineuse ont conduit à établir des recommandations pour la thromboprophylaxie. L'objectif de notre étude était d’évaluer la pratique de cette prophylaxie par les professionnels de santé de Ouagadougou. Méthodes Il s'est agi d'une enquête d'intention réalisée dans le mois de mai 2012 au Centre Hospitalier Universitaire Yalgado Ouédraogo et Centre Médical avec Antenne chirurgicale Paul VI. Un questionnaire a été administré auprès des prescripteurs impliqués dans la prophylaxie de la maladie thromboembolique veineuse (MTEV). Résultats Une interview a été administrée à 86 professionnels de santé dont 20 attachés de santé en anesthésie-réanimation, 17 chirurgiens, 11 médecins généralistes et 07 gynécologue-obstétriciens. Leur expérience professionnelle était inférieure à cinq ans dans 65% des cas et ils exerçaient dans 70% des cas au CHU-YO. Les héparines de bas poids moléculaire étaient les plus utilisées (81,4%) avec une intention de prescription significativement plus élevée en réanimation et en chirurgie (p<0,05). Dans 65,7% des cas, la prophylaxie était maintenue jusqu'à la mobilisation des patients. Le coût élevé de l'héparinothérapie représentait une raison de la non utilisation de la prophylaxie dans 46,5% des cas. Conclusion Nous constatons que la réalisation de la prophylaxie de la MTEV reste insuffisante à Ouagadougou en dépit de l'existence de recommandations précises de bonnes pratiques. Ces résultats suggèrent la nécessité de la formation médicale continue des professionnels de santé, avec l’établissement des recommandations de pratique clinique adaptée à notre niveau de développement. PMID:25995791

  6. Science, Science Education and Their Discontents: A Response to Commentaries on the Paper, "Portrait of a Science Teacher as a Bricoleur--A Case Study from India"

    ERIC Educational Resources Information Center

    Sharma, Ajay

    2008-01-01

    In this response to commentaries by Ali Sammel, Jhumki Basu and Alberto Rodriguez, I present my perspective on three important issues raised by the commentators. These issues relate to the role of a researcher in her field settings and society, the critique of science and science education as oppressive dominant discourses, and co-opting…

  7. Science, Science Education and Their Discontents: A Response to Commentaries on the Paper, "Portrait of a Science Teacher as a Bricoleur--A Case Study from India"

    ERIC Educational Resources Information Center

    Sharma, Ajay

    2008-01-01

    In this response to commentaries by Ali Sammel, Jhumki Basu and Alberto Rodriguez, I present my perspective on three important issues raised by the commentators. These issues relate to the role of a researcher in her field settings and society, the critique of science and science education as oppressive dominant discourses, and co-opting…

  8. KENNEDY SPACE CENTER, FLA. - Ivan Rodriguez, with Bionetics, and Michelle Crouch and Larry Burns, with Dynamac, carry boxes of equipment into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

    NASA Image and Video Library

    2003-09-10

    KENNEDY SPACE CENTER, FLA. - Ivan Rodriguez, with Bionetics, and Michelle Crouch and Larry Burns, with Dynamac, carry boxes of equipment into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

  9. Implications of the Serrano and Rodriguez Cases on the Education of Mexican Americans.

    ERIC Educational Resources Information Center

    Gonzalez, Simon

    The primary local funding source for school support has always been the property or "ad valorum" tax. State funds, determined for each district by the "foundation program" formula, supplement this tax. Local school boards, state legislatures, state constitutions, and the voters have the power to provide quality education. In…

  10. VizieR Online Data Catalog: Young star groups in NGC 300 (Rodriguez+, 2016)

    NASA Astrophysics Data System (ADS)

    Rodriguez, M. J.; Baume, G.; Feinstein, C.

    2016-08-01

    Fundamental characteristics of 1147 young star groups identified in 6 ACS/WFC fields of the galaxy NGC 300. For each group: field of the ACS/WFC, equatorial coordinates, radius, number of stars (the suffix bri indicates bright stars with F555W<25, the suffix dct indicate stars belonging to the decontaminated region, the suffixes blue and red refer to blue and red stars respectively), the magnitude of the brightest star in the group, PDMF slope with its error, and galactocentric distance. (1 data file).

  11. Magnetic polarity stratigraphy of "Mexican Solnhofen" Tlayua Formation, Tepexi de Rodriguez, State of Puebla, Mexico

    NASA Astrophysics Data System (ADS)

    Urrutia Fucugauchi, J.; Zhao, X.; Girdler, S.; Coe, R.; Gogichaishvili, A.; Benammi, M.; Alvarado-Ortega, J.; Urrutia-Fucugauchi, J.

    2005-05-01

    The Tlayua Formation is the richest Cretaceous fossiliferous locality in Mexico. Research in the quarry has yielded thousands of fossil fish associated with other vertebrate remains. From a vertical section, a total of 95 paleomagnetic specimens from 31 horizons were measured to determine the paleomagnetic signal. Limestones are weakly magnetized and exhibit in general two component magnetizations. The magnetic properties and characteristic remanence are dominated by soft and hard coercivity magnetic minerals, most of which probably formed early in the depositional and diagenetic history. Rock-magnetic properties and a positive reversal test suggest that remanence is primary. The section displays both reverse and normal polarities with mean directions: D = 344.9°, I = 32.4°, k= 21, a95= 4.2°; and D = 149.4°, I = -36.6°, k= 17, a95= 8.7°. Comparison with the North America reference curve, indicates tectonic stability of the region since the Cretaceous. Correlation of these polarity zones with the geomagnetic polarity time scale provides a time framework for the discrepancy of the previous biochronological studies. Based on biostratigraphic age assignments using ammonites, the polarity magnetozone sequence correlates with C34n.1n-C34n.2n chrons, with an age of 100 to 105 Ma for the Tlayua Formation.

  12. A diverse assemblage of Anacardiaceae from Oligocene sediments, Tepexi de Rodriguez, Puebla, Mexico.

    PubMed

    Ramírez, José L; Cevallos-Ferriz, Sergio R S

    2002-03-01

    Among the plants collected from the Pie de Vaca Formation of the Oligocene, of Tepexi de Rodríguez, Puebla, México are five plants of Anacardiaceae, Haplorhus medranoensis, Rhus toxicodendron, Rhus sp., Comocladia intermedia, and Pistacia marquezii represented by their leaves and/or leaflets. The past and present diversity and geographic distribution of one of these genera, Rhus, demonstrate its capability to adapt and diversify in a wide variety of environments. Leaf architecture characters of this taxon overlap with those of other genera in the family, suggesting a high degree of phenotypic plasticity. The presence in the Pie de Vaca Formation of a type of Pistacia with leaf architecture characters similar to those of Asian plants further supports a long history of exchange between low-latitude North America and Asia. Links between low-latitude North and South America and the Caribbean are suggested by the presence of Comocladia and Haplorhus. Whereas Comocladia highlights the long history of regional endemics in the area, Haplorhus, today an endemic monotypic genus of Peru, suggests exchange mechanisms between North and South America. The morphologic characters of these taxa, and those of Pseudosmodingium (Anacardiaceae), some Rosaceae, Leguminosae, and Berberidaceae, suggest that the Pie de Vaca community was established and evolved in harsh environmental conditions. The Pie de Vaca flora thus provides significant new insights into the biogeographic relationships of the low latitude vegetation of North America.

  13. Mentoring Matters: Many Voices, Many Choices--Women Who Mentored and Inspired Dana Rodriguez

    ERIC Educational Resources Information Center

    Powell, Mary G.

    2011-01-01

    In this essay, the author traces the progress of one English teacher (Dana) from her days as a middle school student, to her university work, to her emergence as a teacher. The journey reveals that many mentors along the way contributed to the new teacher's sense of purpose, efficacy, and confidence. It is easy to limit one's thinking about the…

  14. Business Is Looking Up: Featuring Renaldo Rodriguez. The Kids on the Block Book Series.

    ERIC Educational Resources Information Center

    Aiello, Barbara; Shulman, Jeffrey

    One of a series of children's books written from the point of view of an elementary grade child with a disability or other problem, the stories emphasize similarities in childhood experience while providing information specific to the disability. In this book, 11-year-old Renaldo, visually impaired since birth, sets up a greeting card service for…

  15. For the relief of Jose de Jesus Ibarra, Monica Ibarra Rodriguez, and Cristina Gamez.

    THOMAS, 111th Congress

    Rep. Johnson, Eddie Bernice [D-TX-30

    2009-01-08

    02/02/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  16. Mentoring Matters: Many Voices, Many Choices--Women Who Mentored and Inspired Dana Rodriguez

    ERIC Educational Resources Information Center

    Powell, Mary G.

    2011-01-01

    In this essay, the author traces the progress of one English teacher (Dana) from her days as a middle school student, to her university work, to her emergence as a teacher. The journey reveals that many mentors along the way contributed to the new teacher's sense of purpose, efficacy, and confidence. It is easy to limit one's thinking about the…

  17. VizieR Online Data Catalog: Stellar multiplicity and debris discs (Rodriguez+, 2015)

    NASA Astrophysics Data System (ADS)

    Rodriguez, D. R.; Duchene, G.; Tom, H.; Kennedy, G. M.; Matthews, B.; Greaves, J.; Butner, H.

    2015-11-01

    The DEBRIS sample consists of 451 stars, of which 2 are not primaries (Fomalhaut B & C; see Mamajek et al. 2013AJ....146..154M; Kennedy et al. 2014MNRAS.438L..96K), and includes the 5 systems observed by the Herschel Guaranteed Time (GT) discs programme (PI: Olofsson). We present the full list of stars and multiplicity information in Table 1. Some systems have tentative evidence of being astrometric binaries, but no additional information exists to confirm this. These systems are treated as single stars for this study. Binaries and higher multiples are listed with more details in Table 2. In general, we only have measurements of the period of spectroscopic binaries and projected separation for visual binaries. We have utilized the AO camera IRCAL at Lick Observatory to search for companions separated from the primary by ~10-1000AU. Tables 4 and 5 list our observations and measured parameters for binary and single stars, respectively. (5 data files).

  18. VizieR Online Data Catalog: Differential uvby photometry of HD 239276 (Rodriguez+, 2006)

    NASA Astrophysics Data System (ADS)

    Rodriguez, E.; Costa, V.; Zhou, A.-Y.; Grigahcene, A.; Dupret, M. A.; Suárez, J. C.; Moya, A.; Lopez-Gonzalez, M. J.; Wei, J.-Y.; Fan, Y.

    2006-06-01

    Table 2 contents 139 simultaneous measurements collected during in each of the four uvby colours of the Stromgren photometric system for the Gamma Doradus variable HD 239276. The observations were carried out by the authors through the years 1986-1987 using the 0.90m telescope at Sierra Nevada Observatory, Spain and the six-channel uvby-Hbeta spectrograph photometer for simultaneous measurements in uvby or in the narrow and wide Hbeta channels, respectively. Table 3 contents 101 measurements collected in the V filter of the Johnson photometric system for the Gamma Doradus variable HD 239276. The observations were carried out by the authors through the year 2001 using the three-channel high-speed photoelectric photometer P45-A mounted on the 0.85m telescope at Xinglong Station of the Beijing Astronomical Observatory, China. Table 4 contents 582 simultaneous measurements collected during in each of the four uvby colours of the Stromgren photometric system for the Gamma Doradus variable HD 239276. The observations were carried out by the authors through the year 2001 using the 0.90m telescope at Sierra Nevada Observatory, Spain and the six-channel uvby-Hbeta spectrograph photometer for simultaneous measurements in uvby or in the narrow and wide Hbeta channels, respectively. (3 data files).

  19. Business Is Looking Up: Featuring Renaldo Rodriguez. The Kids on the Block Book Series.

    ERIC Educational Resources Information Center

    Aiello, Barbara; Shulman, Jeffrey

    One of a series of children's books written from the point of view of an elementary grade child with a disability or other problem, the stories emphasize similarities in childhood experience while providing information specific to the disability. In this book, 11-year-old Renaldo, visually impaired since birth, sets up a greeting card service for…

  20. Euthanasia and assisted suicide in the post-Rodriguez era: lessons from foreign jurisdictions.

    PubMed

    Cormack, M

    2000-01-01

    Euthanasia and assisted suicide are highly controversial subjects that have drawn much attention in Canada over the last two decades. This paper outlines how the Netherlands, the United States, Australia, and Canada have approached the practices. Jurisprudence, public opinion polls, legislative developments, and the positions of medical organizations and their members are included in the analysis. A number of arguments for and against the continued prohibition of the practices in Canada are evaluated. As well, information regarding the extent to which euthanasia and assisted suicide are performed in these countries is assessed. It will be shown that Canadians currently enjoy significant control over decisions concerning end of life. The principles of autonomy and beneficence provide the foundation necessary to justify lifting the prohibition of voluntary euthanasia and assisted suicide in Canada. With regard to the development of safeguards, the way in which foreign jurisdictions have dealt with both procedures is highly instructive. A qualified system of pre-authorization, unlike those adopted elsewhere, would prevent abuses from occurring and maintaining the prohibition of non-voluntary and involuntary euthanasia. Since legislators are in the best position to deal with the issues, change in the law should be made by the government, not the judiciary. Practical legislation is feasible and a proposal of what this should entail is presented.

  1. VizieR Online Data Catalog: Spectra of IPHAS symbiotic stars (Rodriguez-Flores+, 2014)

    NASA Astrophysics Data System (ADS)

    Rodriguez-Flores, E. R.; Corradi, R. L. M.; Mampaso, A.; Garcia-Alvarez, D.; Munari, U.; Greimel, R.; Rubio-Diez, M. M.; Santander-Garcia, M.

    2014-04-01

    We obtained spectra for 18 candidate symbiotic stars in May, June, and December 2012 at the 10.4m Gran Telescopio Canarias (GTC) at the Observatorio del Roque de los Muchachos (La Palma, Spain). The OSIRIS instrument was used in its long-slit mode. The combination of grism R1000B and a slit width of 1" provides a spectral dispersion of 2.1Å per (binned x2) pixel, a resolution of 7Å, and a spectral coverage from 3650 to 7850Å. Exposure times ranged between 100s and 800s, depending of the magnitude of each object. (2 data files).

  2. Caractérisation électrique des interfaces P^+-Si-poly/N-c-Si réalisées par dépôt LPCVD de films fortement dopés in~situ au bore

    NASA Astrophysics Data System (ADS)

    Akani, M.; Benouis, C. E.; Benzohra, M.

    1993-08-01

    Diodes with polycrystalline in situ boron doped emitter deposited by LPCVD on N doped monocrystalline silicon wafers have been analysed electrically with the aim to identify the conduction mechanism through the jonction. In this paper we present the I(V,T) and C (V, T) measurements of the diodes annealed at 1 050 °C during 11 min 45 s in oxygen, argon and nitrogen atmosphere. We also compare the non annealed diode data previously found with our present results, and try to correlate the electrical measurements to the structural analysis [1]. We conclude that the dominant mechanism shows the electrical quality of the studied structures. Des diodes à émetteur polycristallin dopé in situ au bore et déposé par LPCVD sur des plaquettes de silicium monocristallin dopé N sont analysées électriquement dans le but d'identifier les mécanismes de conduction à travers la jonction. Nous présentons les résultats des mesures I (V, T) et C (V, T) des diodes recuites (processées) à 1 050 °C pendant 11 min 45 s dans des atmosphères d'oxygène, d'argon et d'azote et les comparons aux résultats des diodes non recuites. Nous essayons de corréler les résultats des mesures électriques aux analyses de structure réalisées par ailleurs [1]. L'identification du mécanisme de transport prépondérant témoignera de la qualité électrique des structures étudiées.

  3. Ibn Sina, Abu Ali [known as Avicenna] (980-1037)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Islamic philosopher and scientist, born in Kharmaithen, near Bukhara (now Uzbekistan). Avicenna's life was marked by swings of fortune, from physician and favored scholar of a Samanid prince, to peripatetic country doctor when the Samanid regime fell. He became court physician in Hamadan (Iran), where he was for a time imprisoned as a political prisoner. He ended his life in a peaceful, contem...

  4. Qal'eh Hasan Ali maars, central Iran.

    USGS Publications Warehouse

    Milton, D.J.

    1976-01-01

    This group of some 15 Late Quaternary explosion craters are typical maars, with rims of bedded pyroclastics. In all but the largest crater, the deposits consist entirely of clasts of country rock (granodiorite and Eocene volcanics). The maars were formed by phreatomagmatic explosions, possibly caused by groundwater originating from a major river. The deposits of the largest maar contain up to 20% juvenile fragments of two types. Tephrite clasts have phenocrysts of phlogopite, clinopyroxene, olivine and anorthoclase; the presence of hauyne as a groundmass phase is notable. Cumulate blocks of phlogopite-clinopyroxene rock also occur. The maar field is part of a distinct province of Quaternary alkaline volcanism, related to a major crustal fracture - the N-S-trending Nayband fault.-R.J.S.

  5. Trends in incidence and early outcomes in a Black Afro-Caribbean population from 1999 to 2012: Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents Vasculaires Cérébraux II Study.

    PubMed

    Olindo, Stephane; Chausson, Nicolas; Mejdoubi, Mehdi; Jeannin, Severine; Rosillette, Karine; Saint-Vil, Martine; Signate, Aissatou; Edimonana-Kaptue, Mireille; Larraillet, Veronique; Cabre, Philippe; Smadja, Didier; Joux, Julien

    2014-11-01

    Seldom studies are available on trends in stroke incidence in blacks. We aimed to evaluate whether stroke risk prevention policies modified first-ever stroke incidence and outcomes in the black Afro-Caribbean population of Martinique. Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents Vasculaires Cérébraux (ERMANCIA) I and II are 2 sequential prospective population-based epidemiological studies. There have assessed temporal trends in first-ever stroke incidence, risk factors, pathological types, and early outcomes in the black Afro-Caribbean population of Martinique comparing two 12-month periods (1998-1999 and 2011-2012). Crude and age-standardized incidence and 30-day outcomes for stroke in the 2 study periods were compared using Poisson regression. We identified 580 and 544 first-ever strokes in the 2 studies. World age-standardized incidence rates decreased by 30.6% in overall (111 [95% confidence interval, 102-120] versus 77 [95% confidence interval, 70-84]). Rate decline was greater in women than in men (34% versus 26%) particularly in women aged 65 to 74 years (-69%) and 75 to 84 years (-43%). Frequencies of hypertension and diabetes mellitus were unchanged, whereas dyslipidemia, smoking, and atrial fibrillation significantly increased. Only ischemic stroke types showed significant rate reduction in overall and in women, incidence rate ratio (95% confidence intervals) of 0.69 (0.50-0.97) and 0.61 (0.42-0.88), respectively. The overall 30-day case-fatality ratio remained stable (19.3%/17.6%), whereas a better 30-day outcome was found (modified Rankin Score, ≤2 in 47%/37.6%; P=0.03). Over 13 years, there has been a significant decrease (30.6%) in the age-specific first-ever stroke incidence in our Afro-Carribean population. Although prevention policies seem effective, we need to focus on new risk factors limitation and on male population adherence to prevention program. © 2014 American Heart Association, Inc.

  6. VizieR Online Data Catalog: I photometry of very low mass ONC stars (Rodriguez-Ledesma+, 2009)

    NASA Astrophysics Data System (ADS)

    Rodriguez-Ledesma, M. V.; Mundt, R.; Eisloeffel, J.

    2009-06-01

    Table 1 lists the 2908 very low mass objects in the Orion Nebula Cluster with magnitudes between 14-21mag in I band for which accurate photometry was performed. It contains the position, brightness and type of variability of these stars, as well as 2MASS counterparts when available. Table 2 lists the 487 objects found to be periodic in this study, for which their brightness, period and peak-to-peak amplitudes a re given, as well as periods measured in Herbst et al. 2002 (Cat. J/A+A/396/513) when available. (2 data files).

  7. Preliminary Image Map of the 2007 Witch and Poomacha Fire Perimeters, Rodriguez Mountain Quadrangle, San Diego County, California

    USGS Publications Warehouse

    Clark, Perry S.; Scratch, Wendy S.; Bias, Gaylord W.; Stander, Gregory B.; Sexton, Jenne L.; Krawczak, Bridgette J.

    2008-01-01

    In the fall of 2007, wildfires burned out of control in southern California. The extent of these fires encompassed large geographic areas that included a variety of landscapes from urban to wilderness. The U.S. Geological Survey National Geospatial Technical Operations Center (NGTOC) is currently (2008) developing a quadrangle-based 1:24,000-scale image map product. One of the concepts behind the image map product is to provide an updated map in electronic format to assist with emergency response. This image map is one of 55 preliminary image map quadrangles covering the areas burned by the southern California wildfires. Each map is a layered, geo-registered Portable Document Format (.pdf) file. For more information about the layered geo-registered .pdf, see the readme file (http://pubs.usgs.gov/of/2008/1029/downloads/CA_Agua_Dulce_of2008-1029_README.txt). To view the areas affected and the quadrangles mapped in this preliminary project, see the map index (http://pubs.usgs.gov/of/2008/1029/downloads/CA_of2008_1029-1083_index.pdf) provided with this report.

  8. Materials for Adaptive Structural Acoustic Control. Volume 2

    DTIC Science & Technology

    1993-04-06

    headings: 1. General Summary Papers. 2. Materials Studies. 3. Composite Sensors. 4. Actuator Studies. 5. Integration Issues. 6. Processing Studies. 7...both composite sensors and actuators we have continued to explore and exploit the remarkable versatility of the flextensional moonie type structure...cap geometries and load conditions. In actuator studies inultilayer structures have been combined with flextensional moonie endcaps to yield high

  9. An exploration stalemate

    SciTech Connect

    Duey, R.

    1999-11-01

    Venezuela is home to some of the richest hydrocarbon deposits in the world. But activity has slowed due to the country's continued political strife. Mindful of the impact that a shaky political situation at home can have on outside investment, the government has sent new PDVSA president Hector Ciavaldini and Energy Minister Ali Rodriguez, as well as Chavez himself, on road trips to calm the fears of a watchful world. The political climate is discussed in relation to the safety of investments in oil and gas development.

  10. China’s Global Quest for Energy

    DTIC Science & Technology

    2007-01-01

    consumption rate.30 Despite statements made by Venezuelan officials, such as Ali Rodriguez, president of Venezuela’s state-owned oil company, PDVSA , who...1994). Petroleos de Venezuela ( PDVSA ): A state-owned Venezuelan oil company. 20 Rosneft: The only Russian oil company that is completely state...Laverdad. 25 Charles Roth, “Venezuela Plan to Sell US Oil Ops Flawed – Ex- PdVSA Pres,” FWN Select, 2 February 2005, Rigzone, <http://www.rigzone.com> (2

  11. 77 FR 51743 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal....Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management... to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...

  12. Development and Evaluation of Processes for Deposition of Ni/Co-Cr-Aly (MCrAly) Coatings for Gas Turbine Components.

    DTIC Science & Technology

    1979-09-01

    turbine engines demand increasingly higher operating tem- peratures in blades and vanes for greater thrust and efficiency. The turbine components...limitations; namely, expense and the inability to uniformly coat complex geometries and clustered turbine blade and vane airfoils . Thus, another means of...cost and the ability to uniformly coat turbine components of complex geometries and clustered turbine blade and vane airfoils .

  13. Genetics Home Reference: craniofacial microsomia

    MedlinePlus

    ... Luquetti DV, Hing AV. Craniofacial Microsomia Overview. 2009 Mar 19 [updated 2014 Oct 9]. In: Pagon RA, ... 9. doi: 10.3174/ajnr.A2072. Epub 2010 Mar 18. Review. Citation on PubMed Johnson JM, Moonis ...

  14. NCI Blog Post: CPTAC, the Complementary Sibling of TCGA (An Interview with Dr. Henry Rodriguez about NCI’s Proteomics Program) | Office of Cancer Clinical Proteomics Research

    Cancer.gov

    What is proteomics? Proteomics is a highly automated and rapid method for measuring all the proteins in a biological sample. Proteins are the molecules that actually do most of the work inside a cell. When researchers develop cancer drugs, those drugs typically target proteins, so scientists and clinicians really have to understand what the proteins are doing. Proteomics researchers are now able to measure up to 10,000 proteins per tumor sample.

  15. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 16. (Prime Mover Company, The-Rodriguez General Contractors)

    DTIC Science & Technology

    1988-01-01

    ntneW) -4 in (a0 I.Nrr. -WOV f P1 . t- NNNN (0-P w in N- U4nn (0wa- I NNICS NI -4-4 a0. 0.0 a .w I) N NN IWA0 - I LA-I U. . in In C.)L000 N 0 V)M i...4-4-4-4-4 Cy I 00Ios 1 C- NC14-4 ""N N -4-4-4-4 .- 4 -4-I4-4 4 -0 N U OW) r r- I.- - - - P,41 P1 - f . -r 󈧄V I 0000000 100.0 1 0000000 IV0o~ I...0(0. P. P1 %N1=1=N .4 N.4 4 40 -4 ..4..4 .- 140 110000000 40 40 0000000I0-NNO I 1- 10- 100 0 00 V0I Ogg~>(. I 000)C)MI) 0 000000 O 000C4 ON N NNNCM4

  16. Presentation of Guillermo Rodriguez, Jr., Chair, California Postsecondary Education Commission to the Citizens Commission on Higher Education, University of California at Berkeley, Bechtel Engineering Center (September 10, 1998).

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    This presentation identifies six areas of common interest between the California Postsecondary Education Commission (CPEC) and the Citizens Commission on Higher Education: (1) California needs to plan more effectively for the anticipated enrollment growth, particularly at the community college level; (2) the State ought to create a long-term…

  17. Approximating tasseled cap values to evaluate brightness, greenness, and wetness for the Advanced Land Imager (ALI)

    USGS Publications Warehouse

    Yamamoto, Kristina H.; Finn, Michael P.

    2012-01-01

    The Tasseled Cap transformation is a method of image band conversion to enhance spectral information. It primarily is used to detect vegetation using the derived brightness, greenness, and wetness bands. An approximation of Tasseled Cap values for the Advanced Land Imager was investigated and compared to the Landsat Thematic Mapper Tasseled Cap values. Despite sharing similar spectral, temporal, and spatial resolution, the two systems are not interchangeable with regard to Tasseled Cap matrices.

  18. Materials Data on La3(AlI)2 (SG:12) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  19. Development and Evaluation of Game-Like Phonological Awareness Software for Kindergarteners: "JerenAli"

    ERIC Educational Resources Information Center

    Kartal, Günizi; Terziyan, Treysi

    2016-01-01

    The major goal of this study was to develop a game-like software application for phonological awareness training and to evaluate its role in improving phonological awareness skills at the kindergarten level, with the intention to eventually help reading acquisition in Turkish. The participants of the study came from two kindergarten classrooms in…

  20. Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS).

    PubMed

    Holmqvist, Anna Sällfors; Olsen, Jørgen H; Mellemkjaer, Lene; Garwicz, Stanislaw; Hjorth, Lars; Moëll, Christian; Månsson, Bengt; Tryggvadottir, Laufey; Hasle, Henrik; Winther, Jeanette Falck

    2016-09-01

    The pattern of autoimmune diseases in childhood cancer survivors has not been investigated previously. We estimated the risk for an autoimmune disease after childhood cancer in a large, population-based setting with outcome measures from comprehensive, nationwide health registries. From the national cancer registries of Denmark, Iceland and Sweden, we identified 20 361 1-year survivors of cancer diagnosed before the age of 20 between the start of cancer registration in the 1940s and 1950s through 2008; 125 794 comparison subjects, matched by age, gender and country, were selected from national population registers. Study subjects were linked to the national hospital registers. Standardised hospitalisation rate ratios (SHRRs) and absolute excess risks (AERs) were calculated. Childhood cancer survivors had a significantly increased SHRR of 1.4 (95% CI 1.3 to 1.5) of all autoimmune diseases combined, corresponding to an AER of 67 per 100 000 person-years. The SHRRs were significantly increased for autoimmune haemolytic anaemia (16.3), Addison's disease (13.9), polyarteritis nodosa (5.8), chronic rheumatic heart disease (4.5), localised scleroderma (3.6), idiopathic thrombocytopenic purpura (3.4), Hashimoto's thyroiditis (3.1), pernicious anaemia (2.7), sarcoidosis (2.2), Sjögren's syndrome (2.0) and insulin-dependent diabetes mellitus (1.6). The SHRRs for any autoimmune disease were significantly increased after leukaemia (SHRR 1.6), Hodgkin's lymphoma (1.6), renal tumours (1.6) and central nervous system neoplasms (1.4). Childhood cancer survivors are at increased risk for certain types of autoimmune diseases. These findings underscore the need for prolonged follow-up of these survivors. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  1. A Computer Code for the Calculation of NLTE Model Atmospheres Using ALI

    NASA Astrophysics Data System (ADS)

    Kubát, J.

    2003-01-01

    A code for calculation of NLTE model atmospheres in hydrostatic and radiative equilibrium in either spherically symmetric or plane parallel geometry is described. The method of accelerated lambda iteration is used for the treatment of radiative transfer. Other equations (hydrostatic equilibrium, radiative equilibrium, statistical equilibrium, optical depth) are solved using the Newton-Raphson method (linearization). In addition to the standard output of the model atmosphere (dependence of temperature, density, radius, and population numbers on column mass depth) the code enables optional additional outputs for better understanding of processes in the atmosphere. The code is able to calculate model atmospheres of plane-parallel and spherically symmetric semi-infinite atmospheres as well as models of plane parallel and spherical shells. There is also an option for solution of a restricted problem of a NLTE line formation (solution of radiative transfer and statistical equilibrium for a given model atmosphere). The overall scheme of the code is presented.

  2. Oxidation resistant and low coefficient of thermal expansion Nia1-CoCrAly alloy

    NASA Technical Reports Server (NTRS)

    Hebsur, Mohan G. (Inventor)

    2004-01-01

    A bond coat composition for use in thermal barrier coatings comprises a NiAl--CoCrAlY matrix containing particles of AlN dispersed therein. The bond coat composition is prepared by croymilling NiAl and CoCrAlY in liquid nitrogen.

  3. Development and Evaluation of Game-Like Phonological Awareness Software for Kindergarteners: "JerenAli"

    ERIC Educational Resources Information Center

    Kartal, Günizi; Terziyan, Treysi

    2016-01-01

    The major goal of this study was to develop a game-like software application for phonological awareness training and to evaluate its role in improving phonological awareness skills at the kindergarten level, with the intention to eventually help reading acquisition in Turkish. The participants of the study came from two kindergarten classrooms in…

  4. The Al(I) molecule, Ph2COAl and its anion

    NASA Astrophysics Data System (ADS)

    Zhang, Xinxing; Eichhorn, Bryan; Schnöckel, Hansgeorg; Bowen, Kit

    2016-08-01

    We have formed the Al(I)-containing molecule, benzophenone-aluminum, i.e., Ph2COAl, and studied it by conducting density functional theory calculations on both its neutral and anionic forms and by measuring the photoelectron spectrum of its anion. Our calculations identified two nearly iso-energetic anion isomers, (Ph2COAl)-, the vertical detachment energies (VDE) of which are in excellent agreement with our photoelectron spectrum. Natural population analysis (NPA) of Ph2COAl found the Al moiety to be positively charged by +0.81 e, indicating a strongly ionic bond between Al and Ph2CO, i.e., Ph2CO-Al+.

  5. Ali, Cunich: Halley's Churches: Halley and the London Queen Anne Churches

    NASA Astrophysics Data System (ADS)

    Ali, Jason R.; Cunich, Peter

    2005-04-01

    Edmond Halley's enormous contribution to science has received much attention. New research adds an intriguing chapter to his story and concerns his hitherto unexplored association with the baroque architectural visionary Nicholas Hawksmoor, and some important Temple-inspired churches that were built in London in the early 1700s. We argue that Christchurch Spitalfields and St Anne's Limehouse, which were both started in the summer of 1714, were aligned exactly eastwards using ``corrected'' magnetic-compass bearings and that Halley influenced or aided Hawksmoor. By this time the men had probably known each other for 30 years and had recently worked together on the Clarendon Building in Oxford. Despite there being more than 1500 years of Chinese and about 500 years of Western compass technology at the time, these probably represent the first constructions planned using a modern-day ``scientific'' technique. The research also throws light on Halley's contended religious position.

  6. The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali.

    PubMed

    Maziah, Mahmood; Rosli, Noormi

    2009-01-01

    Plant cell culture technology is potentially useful in producing high-valued secondary metabolites. Eurycoma longifolia root extracts are consumed as a health tonic but more popularly used as an aphrodisiac. Studies on the aphrodisiac properties and the possible compounds involved have been widely studied. There are many potentially useful compounds reported from the root extracts of E. longifolia. However, studies on the in vitro production of useful compounds from this plant have not been reported. This chapter will describe methods of callus induction and extraction of 9-methoxycanthin-6-one from E. longifolia Jack explants with emphasis on the tap and fibrous roots. This compound, known to have anti-tumour activity, is present in intact plant parts and in callus tissues of different explants.

  7. LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang).

    PubMed

    Chua, Lee Suan; Amin, Nor Amaiza Mohd; Neo, Jason Chun Hong; Lee, Ting Hun; Lee, Chew Tin; Sarmidi, Mohamad Roji; Aziz, Ramlan Abdul

    2011-12-15

    A number of three LC-MS/MS hybrid systems (QTof, TripleTof and QTrap) has been used to profile small metabolites (m/z 100-1000) and to detect the targeted metabolites such as quassinoids, alkaloids, triterpene and biphenylneolignans from the aqueous extracts of Eurycoma longifolia. The metabolite profiles of small molecules showed four significant clusters in the principle component analysis for the aqueous extracts of E. longifolia, which had been collected from different geographical terrains (Perak and Pahang) and processed at different extraction temperatures (35°C and 100°C). A small peptide of leucine (m/z 679) and a new hydroxyl methyl β-carboline propionic acid have been identified to differentiate E. longifolia extracts that prepared at 35°C and 100°C, respectively. From the targeted metabolites identification, it was found that 3,4ɛ-dihydroeurycomanone (quassinoids) and eurylene (squalene-type triterpene) could only be detected in the Pahang extract, whereas canthin-6-one-3N-oxide could only be detected in the Perak extract. Overall, quassinoids were present in the highest concentration, particularly eurycomanone and its derivatives compared to the other groups of metabolites. However, the concentration of canthin-6-one and β-carboline alkaloids was significantly increased when the roots of the plant samples were extracted at 100°C.

  8. ALI (Autonomous Lunar Investigator): Revolutionary Approach to Exploring the Moon with Addressable Reconfigurable Technology

    NASA Technical Reports Server (NTRS)

    Clark, P. E.; Curtis, S. A.; Rilee, M. L.; Floyd, S. R.

    2005-01-01

    Addressable Reconfigurable Technology (ART) based structures: Mission Concepts based on Addressable Reconfigurable Technology (ART), originally studied for future ANTS (Autonomous Nanotechnology Swarm) Space Architectures, are now being developed as rovers for nearer term use in lunar and planetary surface exploration. The architecture is based on the reconfigurable tetrahedron as a building block. Tetrahedra are combined to form space-filling networks, shaped for the required function. Basic structural components are highly modular, addressable arrays of robust nodes (tetrahedral apices) from which highly reconfigurable struts (tetrahedral edges), acting as supports or tethers, are efficiently reversibly deployed/stowed, transforming and reshaping the structures as required.

  9. Recommended ALIs and DACs for 10 CFR part 220: A consistent numerical set

    SciTech Connect

    Eckerman, K.F.

    1996-05-01

    Appendix B to 10 CFR Part 20 contains numerical data for controlling the intake of radionuclides in the workplace or in the environment. These data, derived from the recommendations of the International Commission on Radiological Protection (ICRP), do not provide a numerically consistent basis for demonstrating compliance with the limitation on dose stated in the regulation. This situation is largely a consequence of the numerical procedures used by the ICRP which did not maintain, in a strict numerical sense, the hierarchial relationship among the radiation protection quantities. In this work recommended values of the quantities in Appendix B to CFR Part 20 are developed using the dose coefficients of the applicable ICRP publications and a numerical procedure which ensures that the tabulated quantities are numerically consistent.

  10. Antiferroelectric Topological Insulators in Orthorhombic AMgBi Compounds (A=Li, Na, K).

    PubMed

    Monserrat, Bartomeu; Bennett, Joseph W; Rabe, Karin M; Vanderbilt, David

    2017-07-21

    We introduce antiferroelectric topological insulators as a new class of functional materials in which an electric field can be used to control topological order and induce topological phase transitions. Using first principles methods, we predict that several alkali-MgBi orthorhombic members of an ABC family of compounds are antiferroelectric topological insulators. We also show that epitaxial strain and hydrostatic pressure can be used to tune the topological order and the band gap of these ABC compounds. Antiferroelectric topological insulators could enable precise control of topology using electric fields, enhancing the applicability of topological materials in electronics and spintronics.

  11. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... Institution, P.O. Box 1000, White Deer, PA 17887 and 547 Green Hill Lane, Berwyn, PA 19312. On January 11..., P.O. Box 1000, White Deer, PA 17887, and 547 Green Hill Lane, Berwyn, PA 19312, and when acting for...

  12. 76 FR 26978 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ..., identified by Docket No. FEMA-B-1190, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal... comments to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...

  13. 76 FR 1121 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ..., identified by Docket No. FEMA-B-1170, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal... comments to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...

  14. 76 FR 45215 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ..., identified by Docket No. FEMA-B- 1075, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal... comments to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...

  15. 76 FR 28376 - Airworthiness Directives; Fokker Services B.V. Model F.28 Mark 1000, 2000, 3000, and 4000 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... after receipt. FOR FURTHER INFORMATION CONTACT: Tom Rodriguez, Program Manager, International Branch... International Branch, send it to ATTN: Tom Rodriguez, Program Manager, International Branch, ANM-116, Transport...

  16. 78 FR 23458 - Airworthiness Directives; Dassault Aviation Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... CONTACT: Tom Rodriguez, Aerospace Engineer, International Branch, ANM-116, Transport Airplane Directorate... information directly to the International Branch, send it to ATTN: Tom Rodriguez, Aerospace Engineer...

  17. [Etiological and pathogenetic aspects of joint diseases in Abu Ali Ibn Sina's papers and their modern significance].

    PubMed

    Abduvaliev, A A

    2006-01-01

    It is established that the basis of theoretical background on etiological and pathogenetic aspects of joint diseases have been made in connection with an ancient doctrine of elements, basic qualities, joint fluid and mizadj. Pathological process in a joint is associated with quantitative-qualitative changes of structure of joint fluid and its penetration into the joint with subsequent change of mizadj. The doctrine about mizadj is the main idea of Avicenna on health and illness and also the basis of signs of all system of human being, which are significant during diagnostics. The study of reasons and mechanisms of illnesses of the locomotor system against Avicenna's positions will throw light, for sure, on many unresolved problems of modern arthroloogy.

  18. ICU Exposures for Long-Term Outcomes Research: Development and Description of Exposures for 150 ALI Patients

    PubMed Central

    Needham, Dale M.; Wang, Weiwei; Desai, Sanjay V.; Mendez-Tellez, Pedro A.; Dennison, Cheryl R.; Sevransky, Jonathan; Shanholtz, Carl; Ciesla, Nancy; Spillman, Kim; Pronovost, Peter J.

    2012-01-01

    Purpose Long-term follow-up studies in critical care have described survivors’ outcomes, but provided less insight into the patient/disease characteristics and intensive care therapies (“exposures”) associated with these outcomes. Such insights are essential for improving patients’ long-term outcomes. This report describes the development of a strategy for comprehensively measuring relevant exposures for long-term outcomes research, and presents empirical results from its implementation. Materials and Methods A multi-step, iterative process was used to develop the exposures strategy. First, a comprehensive list of potential exposures was generated and subsequently reduced based on feasibility, redundancy, and relevance criteria. Next, data abstraction methods were designed and tested. Finally, the strategy was implemented in 150 acute lung injury patients with iterative refinement. Results The strategy resulted in development of >60 unique exposures requiring <45 minutes per patient-day for data collection. The vast majority of exposures had minimal missing data and adequate reliability. These data revealed that evidence-based practices including lower tidal volume ventilation, spontaneous breathing trials, sedation interruption, adequate nutrition, and blood glucose <6.1 mmol/L (110 mg/dl) occurred in only 23%-50% of assessments. Conclusions Using a multi-step, iterative process, a comprehensive and feasible exposure measurement strategy for long-term outcomes research was successfully developed and implemented. PMID:18086397

  19. Predicting plot basal area and tree density in mixed-conifer forest from lidar and Advanced Land Imager (ALI) data

    Treesearch

    Andrew T. Hudak; Jeffrey S. Evans; Michael J. Falkowski; Nicholas L. Crookston; Paul E. Gessler; Penelope Morgan; Alistair M. S. Smith

    2005-01-01

    Multispectral satellite imagery are appealing for their relatively low cost, and have demonstrated utility at the landscape level, but are typically limited at the stand level by coarse resolution and insensitivity to variation in vertical canopy structure. In contrast, lidar data are less affected by these difficulties, and provide high structural detail, but are less...

  20. Oxidation resistant and low coefficient of thermal expansion NiA1-CoCrAly alloy

    NASA Technical Reports Server (NTRS)

    Hebsur, Mohan G. (Inventor)

    2002-01-01

    A bond coat composition for use in thermal barrier coatings comprises a NiAl--CoCrAlY matrix containing particles of AlN dispersed therein. The bond coat composition is prepared by croymilling NiAl and CoCrAlY in liquid nitrogen.

  1. VizieR Online Data Catalog: PCF, SpecB or SDSSB asteroids parameters (Ali-Lagoa+, 2016)

    NASA Astrophysics Data System (ADS)

    Ali-Lagoa, V.; Licandro, J.; Gil-Hutton, R.; Canada-Assandri, M.; Delbo, M.; de Leon, J.; Campins, H.; Pinilla-Alonso, N.; Kelley, M. S. P.; Hanus, J.

    2016-04-01

    The table contains the best-fitting values of size and beaming parameter and corresponding visible geometric albedos for all our objects. We fitted the near-Earth asteroid thermal model of Harris (1998Icar..131..291H) to WISE/NEOWISE thermal infrared data (see, e.g., Mainzer et al., 2011ApJ...736..100M and Masiero et al., 2014ApJ...791..121M). Minimum relative errors of 10, 15, and 20 percent should be considered for size, beaming parameter and albedo in those cases for which the beaming parameter could be fitted. Otherwise, a default value of the beaming parameter is assumed (its negative value is given in the table) and the minimum relative errors in size and albedo increase to 20 and 40 percent (see, e.g., Mainzer et al., 2011ApJ...736..100M). We also provide the asteroid absolute magnitudes and slope parameters retrieved from the Minor Planet Center (MPC), the number of observations used in each WISE band (W3 and W4), plus the corresponding average values of heliocentric and geocentric distances and phase angle (r, g, a) based on the ephemerides taken from the MIRIADE service (http://vo.imcce.fr/webservices/miriade/?ephemph). The subsample label indicates whether the object belongs to the SDSS, spectroscopic B or PCF groups. Labels with the suffix 'qA' indicate that only data with signal-to- noise ratio greater than 10 were used for that case (see Appendix A of the article for more details). (1 data file).

  2. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for.... Table 2 provides concentration limits for airborne and liquid effluents released to the general...

  3. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for.... Table 2 provides concentration limits for airborne and liquid effluents released to the general...

  4. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for.... Table 2 provides concentration limits for airborne and liquid effluents released to the general...

  5. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for.... Table 2 provides concentration limits for airborne and liquid effluents released to the general...

  6. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for... Concentrations (DACs) of Radionuclides for Occupational Exposure; Effluent Concentrations; Concentrations for.... Table 2 provides concentration limits for airborne and liquid effluents released to the general...

  7. JGME-ALiEM Hot Topics in Medical Education: Analysis of a Multimodal Online Discussion About Team-Based Learning.

    PubMed

    Riddell, Jeff; Patocka, Catherine; Lin, Michelle; Sherbino, Jonathan

    2017-02-01

    Team-based learning (TBL) is an instructional method that is being increasingly incorporated in health professions education, although use in graduate medical education (GME) has been more limited. To curate and describe themes that emerged from a virtual journal club discussion about TBL in GME, held across multiple digital platforms, while also evaluating the use of social media in online academic discussions. The Journal of Graduate Medical Education (JGME) and the Academic Life in Emergency Medicine blog facilitated a weeklong, open-access, virtual journal club on the 2015 JGME article "Use of Team-Based Learning Pedagogy for Internal Medicine Ambulatory Resident Teaching." Using 4 stimulus questions (hosted on a blog as a starting framework), we facilitated discussions via the blog, Twitter, and Google Hangouts on Air platforms. We evaluated 2-week web analytics and performed a thematic analysis of the discussion. The virtual journal club reached a large international audience as exemplified by the blog page garnering 685 page views from 241 cities in 42 countries. Our thematic analysis identified 4 domains relevant to TBL in GME: (1) the benefits and barriers to TBL; (2) the design of teams; (3) the role of assessment and peer evaluation; and (4) crowdsourced TBL resources. The virtual journal club provided a novel forum across multiple social media platforms, engaging authors, content experts, and the health professions education community in a discussion about the importance, impediments to implementation, available resources, and logistics of adopting TBL in GME.

  8. The Prevalence of fungal infections in children with hematologic malignancy in Ali-Asghar Children Hospital between 2005 and 2010.

    PubMed

    Ansari, Sh; Shirzadi, E; Elahi, M

    2015-01-01

    A fungal infection represents a growing problem in children with hematologic malignancies, during chemotherapy induced neutropenia. Fungal colonization is considered a major risk factor for subsequent fungal infections. The aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in Tehran, Iran. 617 hematological patients in the age range of neoteric to 19 years old were enrolled and 87 cases with invasive fungal infections were extracted from patients' files and documented. Diagnosis of fungal infections was based on the local biopsy and pathology for mucormycosis, blood culture, urine culture and clinical examination for candidasis and galactomannan for aspergillus. the mean age of cancer diagnosis was 6.33 years old and the mean age of fungal infection was 7.95 years old. The majority of the infections was caused by candidia spp (74.7%), followed by aspergillus spp (17.2%) and zygomycetes (11.5%). Among candidiasis patients, oral infection had the highest manifestation (92.3%) whereas in 10 of 15 patients with aspergillus, the infectious site was the lung. There was a significant association between mortality and the type of fungal infection (p <0.0001). Our finding suggests that there is a high rate of fungal infections in children receiving remission therapy for onco-hematology. These results help improve the management of these patients, however Further studies are needed.

  9. The Prevalence of fungal infections in children with hematologic malignancy in Ali-Asghar Children Hospital between 2005 and 2010

    PubMed Central

    Ansari, Sh; Shirzadi, E; Elahi, M

    2015-01-01

    Background A fungal infection represents a growing problem in children with hematologic malignancies, during chemotherapy induced neutropenia. Fungal colonization is considered a major risk factor for subsequent fungal infections. The aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in Tehran, Iran. Materials and Methods 617 hematological patients in the age range of neoteric to 19 years old were enrolled and 87 cases with invasive fungal infections were extracted from patients' files and documented. Diagnosis of fungal infections was based on the local biopsy and pathology for mucormycosis, blood culture, urine culture and clinical examination for candidasis and galactomannan for aspergillus. Results the mean age of cancer diagnosis was 6.33 years old and the mean age of fungal infection was 7.95 years old. The majority of the infections was caused by candidia spp (74.7%), followed by aspergillus spp (17.2%) and zygomycetes (11.5%). Among candidiasis patients, oral infection had the highest manifestation (92.3%) whereas in 10 of 15 patients with aspergillus, the infectious site was the lung. There was a significant association between mortality and the type of fungal infection (p <0.0001). Conclusion Our finding suggests that there is a high rate of fungal infections in children receiving remission therapy for onco-hematology. These results help improve the management of these patients, however Further studies are needed. PMID:25914797

  10. VizieR Online Data Catalog: WISE/NEOWISE Mars-crossing asteroids (Ali-Lagoa+, 2017)

    NASA Astrophysics Data System (ADS)

    Ali-Lagoa, V.; Delbo, M.

    2017-07-01

    We fitted the near-Earth asteroid thermal model of Harris (1998, Icarus, 131, 29) to WISE/NEOWISE thermal infrared data (see, e.g., Mainzer et al. 2011ApJ...736..100M, and Masiero et al. 2014, Cat. J/ApJ/791/121). The table contains the best-fitting values of size and beaming parameter. We note that the beaming parameter is a strictly positive quantity, but a negative sign is given to indicate whenever we could not fit it and had to assume a default value. We also provide the visible geometric albedos computed from the diameter and the tabulated absolute magnitudes. Minimum relative errors of 10, 15, and 20 percent should be considered for size, beaming parameter and albedo in those cases for which the beaming parameter could be fitted. Otherwise, the minimum relative errors in size and albedo increase to 20 and 40 percent (see, e.g., Mainzer et al. 2011ApJ...736..100M). The asteroid absolute magnitudes and slope parameters retrieved from the Minor Planet Center (MPC) are included, as well as the number of observations used in each WISE band (nW2, nW3, nW4) and the corresponding average values of heliocentric and geocentric distances and phase angle of the observations. The ephemerides were retrieved from the MIRIADE service (http://vo.imcce.fr/webservices/miriade/?ephemph). (1 data file).

  11. Referring the bill (H.R. 798), entitled "For the relief of Adrian Rodriguez", to the chief judge of the United States Court of Federal Claims for a report thereon.

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-02-03

    03/16/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  12. Referring the bill (H.R. 798), entitled "For the relief of Adrian Rodriguez", to the chief judge of the United States Court of Federal Claims for a report thereon.

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-02-03

    03/16/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  13. Referring the bill (H.R. 798), entitled "For the relief of Adrian Rodriguez", to the chief judge of the United States Court of Federal Claims for a report thereon.

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-02-03

    House - 03/16/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. ScienceCast 75: Watch Out For The Blue Moon

    NASA Image and Video Library

    2012-08-29

    The second full Moon of August--a "Blue Moon"--is just around the corner. It will probably look just like any other full Moon but, on rare occasions, the Moon really does turn blue. Could it happen this month?

  15. First record of Anastrepha zacharyi Norrbom (Diptera, Tephritidae) in Brazil, and notes on its host plant and parasitoid

    USDA-ARS?s Scientific Manuscript database

    Cryptodacus bernardoi Rodriguez & Rodriguez, new species, is described from Colombia. It was reared from fruits of Phoradendron sp. near piperoides (Kunth) Trel. New distribution records are reported for Cryptodacus ornatus Norrbom from Colombia and Peru, for Cryptodacus trinotatus Norrbom & Korytko...

  16. 75 FR 78664 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ..., identified by Docket No. FEMA-B-1169, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management...

  17. 76 FR 16722 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management... . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal... locations of all BFEs to be changed. Send comments to Luis Rodriguez, Chief, Engineering Management Branch...

  18. 76 FR 56724 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... Docket No. FEMA-B-1214, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management... changed. Send comments to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and...

  19. 76 FR 26976 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ..., identified by Docket No. FEMA-B-1193, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management...

  20. 75 FR 75949 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ..., identified by Docket No. FEMA-B-1161, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management...

  1. 76 FR 43965 - Proposed Flood Elevation Determinations; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and... changed. Send comments to Luis Rodriguez, Chief, Engineering Management Branch, Mitigation Directorate... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations...

  2. 76 FR 3590 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ..., identified by Docket No. FEMA-B-1171, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management...

  3. 76 FR 26982 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ...- 1021, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management... changed. Send comments to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and...

  4. A new species and new records of Cryptodacus (Diptera: Tephritidae) from Colombia, Bolivia and Peru

    USDA-ARS?s Scientific Manuscript database

    Cryptodacus bernardoi Rodriguez & Rodriguez, new species, is described from Colombia. It was reared from fruits of Phoradendron sp. near piperoides (Kunth) Trel. New distribution records are reported for Cryptodacus ornatus Norrbom from Colombia and Peru, for Cryptodacus trinotatus Norrbom & Korytko...

  5. Magnetic and electrical behavior of La 1-xA xMnO 3 (A=Li, Na, K and Rb) manganites

    NASA Astrophysics Data System (ADS)

    Kalyana Lakshmi, Y.; Venkataiah, G.; Vithal, M.; Venugopal Reddy, P.

    2008-09-01

    With a view to understand the magnetic and electrical behavior of monovalent substituted lanthanum manganites, a series of materials were prepared by sol-gel route by sintering at 1200 °C. The X-ray diffraction data were analyzed using Rietveld refinement technique and it has been found that all the samples were found to crystallize into rhombohedral structure with R3barc space group. The values of ferro to paramagnetic ( TC) and metal-insulator transition ( TP) temperatures were obtained using ac susceptibility and electrical resistivity data, respectively. It has been found that sodium-, potassium- and rubidium-doped samples exhibit two peaks in the electrical resistivity vs. temperature plots. The observed behavior has been explained on the basis of oxygen deficiency present in the samples. The electrical resistivity data were analyzed using various theoretical models and it has been concluded that the electrical resistivity data in the low-temperature regime ( T< TP) can be explained using the equation ρ(T)= ρ0+ ρ2T2+ ρ4.5T4.5, signifying the importance of the grain/domain boundary, electron-electron and two magnon scattering processes. On the other hand, the high-temperature resisitivity data ( T> TP) were explained using variable range and small polaron hopping mechanisms.

  6. Is photography-based taxonomy really inadequate, unnecessary, and potentially harmful for biological sciences? A reply to Ceríaco et al.> (2016).

    PubMed

    Thorpe, Stephen E

    2017-01-26

    An opinion piece was recently published in this journal which, remarkably, is less than one page in length, but has 493 authors (signatories) and has gained over 15 thousand reads on ResearchGate in a very short time. Ceríaco et al. (2016) argue for a blanket ban to be imposed on the uncommon practice of basing new species descriptions in zoology on photographic evidence only of the animal. I herein aim to show that their argument is a non sequitur, i.e. their stated reasons do not support their desired conclusion.

  7. Hospital contacts for endocrine disorders in Adult Life after Childhood Cancer in Scandinavia (ALiCCS): a population-based cohort study.

    PubMed

    de Fine Licht, Sofie; Winther, Jeanette Falck; Gudmundsdottir, Thorgerdur; Holmqvist, Anna Sällfors; Bonnesen, Trine Gade; Asdahl, Peter Haubjerg; Tryggvadottir, Laufey; Anderson, Harald; Wesenberg, Finn; Malila, Nea; Holm, Kirsten; Hasle, Henrik; Olsen, Jørgen Helge

    2014-06-07

    The pattern of endocrine disorders in long-term survivors of childhood cancer has not been investigated comprehensively. Here, we aimed to assess the lifetime risk of these disorders in Nordic survivors of childhood cancer. From the national cancer registries of Denmark, Finland, Iceland, Norway, and Sweden, we identified 31,723 1-year survivors of childhood cancer, notified since the start of registration in the 1940s and 1950s. From the national population registries, we randomly selected a comparison cohort of people matched by age, sex, and country. Study participants were linked to the national hospital registries, and observed numbers of first-time hospital contacts for endocrine disorders in survivors of childhood cancer were compared with the expected numbers derived from the population comparison cohort. We calculated the absolute excess risks attributable to status as a childhood cancer survivor and standardised hospitalisation rate ratios (SHRRs). Of the childhood cancer survivors, 3292 had contact with a hospital for an endocrine disorder, yielding a SHRR of 4·8 (95% CI 4·6-5·0); the highest risks were in survivors of leukaemia (SHRR 7·3 [95% CI 6·7-7·9]), CNS tumours (6·6 [6·2-7·0]), and Hodgkin's lymphoma (6·2 [5·6-7·0]). The absolute excess risk for endocrine disorders was roughly 1000 per 100,000 person-years before 20 years of age, and 400 per 100,000 person-years during the remaining lifetime. For children with cancer diagnosed at 5-9 years of age, the cumulative risk for endocrine disorders was highest, and reached 43% at the age of 60 years. Diagnoses of pituitary hypofunction (SHRR 88·0), hypothyroidism (9·9), and testicular and ovarian dysfunction (42·5 and 4·7, respectively) together constituted 61% (655 of 1078) of all excess disease-induced and treatment-induced endocrine disorders in survivors of childhood cancer. A cumulative risk for endocrine disorders at 60 years of age of above 40% in survivors of childhood cancer emphasises the importance of minimisation of damaging treatment, intensification of secondary prevention, and targeting of survivor follow-up throughout life. Since most long-term childhood cancer survivors are not followed in a specialised late-effect clinic, they are a growing challenge for the primary care physician and medical specialists working outside the late-effect area. The Danish Council for Strategic Research. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... processing/use workers only, requirements as specified in § 721.63(a)(4), (a)(5)(iv), (a)(5)(v), (a)(5)(vi... paragraph: This substance may cause systemic effects, eye irritation. (iii) Industrial, commercial,...

  9. Acoustic phonon modes in asymmetric AlxGa1-xN/GaN/AlyGa1-yN quantum wells

    NASA Astrophysics Data System (ADS)

    Zan, Y. H.; Ban, S. L.; Chai, Y. J.; Qu, Y.

    2017-02-01

    Using an elastic continuum model, the dispersion relations and phonon modes of propagating, confined, half space and interface acoustic phonons in asymmetric AlxGa1-xN/GaN/Al1-yGayN quantum wells (QWs) have been solved theoretically with the varieties of Al components x and y. Contrary to the previous conclusions, some regulations for the existence of the above different acoustic phonons are revealed as well as the transition conditions among these modes are also discussed. With increase of wave vectors, the dispersion relations split into several groups. Because the classification of these groups is related to the eigen frequencies of bulk materials forming QWs, phonon modes in these groups will be confined or propagating in different layers of QWs. Furthermore, the gradients of the dispersion relations' asymptotes are the velocities of longitudinal and the transverse acoustic phonons propagating in bulk materials in turns. The properties of the dispersion relations and their phonon modes are also analyzed in depth based on the cut-off conditions. By the changing of Al components x and y, the bottom of these groups will be modified to adjust eigen frequencies of AlxGa1-xN or Al1-yGayN layers. But the propagation properties of acoustic phonon modes will remain unchanged in each section.

  10. Controlling the compositional inhomogeneities in AlxGa1-xN/AlyGa1-yN MQWs grown by PA-MBE: Effect on luminescence properties

    NASA Astrophysics Data System (ADS)

    Pramanik, Pallabi; Sen, Sayantani; Singha, Chirantan; Roy, Abhra Shankar; Das, Alakananda; Sen, Susanta; Bhattacharyya, Anirban; Kumar, Deepak; Sridhara Rao, D. V.

    2016-04-01

    Al0.35Ga0.65N/Al0.55Ga0.45N MQWs were grown by PA-MBE using a range of group III/V flux ratios. TEM images indicate sharp interfaces and well/barrier widths of 1.5/2 nm. We observe that small variations of group III/V flux ratio cause dramatic variations in the room temperature photoluminescence (PL) spectra. In addition to band edge luminescence, multiple low energy PL peaks are observed for growths under excess group III conditions, which are absent for near-stoichiometric growth. Temperature dependent PL measurements indicate that at room temperature, emission occurs due to transitions at potential fluctuations generated by the presence of compositional inhomogeneity. These effects are dominant for growth under excess group III conditions due to the presence of a metallic layer on the growth surface during deposition. This can be eliminated by the use of an Indium surfactant during growth, which modifies the diffusion length of Ga and Al adatoms. Under these conditions, the optical properties of MQWs are relatively insensitive to variations in group III to V flux ratio and hence substrate temperature, thus making them suitable for industrial-scale fabrication of optoelectronic devices in the ultraviolet range.

  11. Review of Frigitilla Williams in Bartholomay et al.>, 2015, with description of a new species from Panama (Hymenoptera: Mutillidae).

    PubMed

    Cambra, Roberto A; Brothers, Denis J; Quintero, Diomedes

    2016-11-10

    Frigitilla panamensis Cambra, Brothers & Quintero sp. nov., from Panama, based on females, is described and illustrated. This new species represents the northernmost distribution record for the Neotropical genus Frigitilla Williams in Bartholomay et al., 2015. New synonymy and combination are proposed for Frigitilla simulatrix (F. Smith, 1879), comb. nov. =Mutilla frigidula Cresson, 1902, syn. nov. A lectotype is designated for Mutilla simulatrix F. Smith, 1879. The differentiating characters for the genus are briefly discussed.

  12. Youth Self-Formation and the "Capacity to Aspire": The Itinerant "Schooled" Career of Fuzile Ali across Post-Apartheid Space

    ERIC Educational Resources Information Center

    Fataar, Aslam

    2010-01-01

    This article is a narrative analysis of one young boy's encounter with his schooling across the rural and urban landscape. It is set against the backdrop of the changing social reproductive context of education in South Africa in the democratic period. Based on in-depth qualitative interviews, the analysis probed the subjective basis on which this…

  13. Oxidative Cleavage of C=S and P=S Bonds at an Al(I) Center: Preparation of Terminally Bound Aluminum Sulfides.

    PubMed

    Chu, Terry; Vyboishchikov, Sergei F; Gabidullin, Bulat; Nikonov, Georgii I

    2016-10-10

    The treatment of cyclic thioureas with the aluminum(I) compound NacNacAl (1; NacNac=[ArNC(Me)CHC(Me)NAr](-) , Ar=2,6-Pr(i)2 C6 H3 ) resulted in oxidative cleavage of the C=S bond and the formation of 3 and 5, the first monomeric aluminum complexes with an Al=S double bond stabilized by N-heterocyclic carbenes. Compound 1 also reacted with triphenylphosphine sulfide in a similar manner, which resulted in cleavage of the P=S bond and production of the adduct [NacNacAl=S(S=PPh3 )] (8). The Al=S double bond in 3 can react with phenyl isothiocyanate to furnish the cycloaddition product 9 and zwitterion 10 as a result of coupling between the liberated carbene and PhN=C=S. All novel complexes were characterized by multinuclear NMR spectroscopy, and the structures of 5, 9, and 10 were confirmed by X-ray diffraction analysis. The nature of the Al=S bond in 5 was also probed by DFT calculations.

  14. Barriers of the Development of Web-Based Training in Agricultural Higher Education System in Iran: A Case Study of Hamadan Bu Ali Sina University, Iran

    ERIC Educational Resources Information Center

    Saadi, Heshmatollah; Mirzayi, Khalil; Movahedi, Reza

    2016-01-01

    Recently, higher education systems seek to use network-based and Internet-based information technologies in education, teaching and learning. E-learning in Iran higher education system has been started since 2003, however, its development has been very slow. The present study is a survey research. The participants of the study are faculty members,…

  15. JGME-ALiEM Hot Topics in Medical Education Online Journal Club: An Analysis of a Virtual Discussion About Resident Teachers.

    PubMed

    Sherbino, Jonathan; Joshi, Nikita; Lin, Michelle

    2015-09-01

    In health professionals' education, senior learners play a key role in the teaching of junior colleagues. We describe an online discussion about residents as teachers to highlight the topic and the online journal club medium. In January 2015, the Journal of Graduate Medical Education (JGME) and the Academic Life in Emergency Medicine blog facilitated an open-access, online, weeklong journal club on the JGME article "What Makes a Great Resident Teacher? A Multicenter Survey of Medical Students Attending an Internal Medicine Conference." Social media platforms used to promote asynchronous discussions included a blog, a video discussion via Google Hangouts on Air, and Twitter. We performed a thematic analysis of the discussion. Web analytics were captured as a measure of impact. The blog post garnered 1324 page views from 372 cities in 42 countries. Twitter was used to endorse discussion points, while blog comments provided opinions or responded to an issue. The discussion focused on why resident feedback was devalued by medical students. Proposed explanations included feedback not being labeled as such, the process of giving delivery, the source of feedback, discrepancies with self-assessment, and threats to medical student self-image. The blog post resulted in a crowd-sourced repository of resident teacher resources. An online journal club provides a novel discussion forum across multiple social media platforms to engage authors, content experts, and the education community. Crowd-sourced analysis of the resident teacher role suggests that resident feedback to medical students is important, and barriers to student acceptance of feedback can be overcome.

  16. Barriers of the Development of Web-Based Training in Agricultural Higher Education System in Iran: A Case Study of Hamadan Bu Ali Sina University, Iran

    ERIC Educational Resources Information Center

    Saadi, Heshmatollah; Mirzayi, Khalil; Movahedi, Reza

    2016-01-01

    Recently, higher education systems seek to use network-based and Internet-based information technologies in education, teaching and learning. E-learning in Iran higher education system has been started since 2003, however, its development has been very slow. The present study is a survey research. The participants of the study are faculty members,…

  17. Youth Self-Formation and the "Capacity to Aspire": The Itinerant "Schooled" Career of Fuzile Ali across Post-Apartheid Space

    ERIC Educational Resources Information Center

    Fataar, Aslam

    2010-01-01

    This article is a narrative analysis of one young boy's encounter with his schooling across the rural and urban landscape. It is set against the backdrop of the changing social reproductive context of education in South Africa in the democratic period. Based on in-depth qualitative interviews, the analysis probed the subjective basis on which this…

  18. Influence of inelastic collisions with hydrogen atoms on the formation of AlI and SiI lines in stellar spectra

    NASA Astrophysics Data System (ADS)

    Mashonkina, L. I.; Belyaev, A. K.; Shi, J.-R.

    2016-06-01

    We have performed calculations by abandoning the assumption of local thermodynamic equilibrium (within the so-called non-LTE approach) for Al I and Si I with model atmospheres corresponding to stars of spectral types F-G-Kwith differentmetal abundances. To take into account inelastic collisions with hydrogen atoms, for the first time we have applied the cross sections calculated by Belyaev et al. using model approaches within the formalism of the Born-Oppenheimer quantum theory. We show that for Al I non-LTE leads to higher ionization (overionization) than in LTE in the spectral line formation region and to a weakening of spectral lines, which is consistent with earlier non-LTE studies. However, our results, especially for the subordinate lines, differ quantitatively from the results of predecessors. Owing to their large cross sections, the ion-pair production and mutual neutralization processes Al I( nl) + HI(1 s) ↔ Al II(3 s 2) + H- provide a close coupling of highly excited Al I levels with the Al II ground state, which causes the deviations from the equilibrium level population to decrease compared to the calculations where the collisions only with electrons are taken into account. For three moderately metal-deficient dwarf stars, the aluminum abundance has been determined from seven Al I lines in different models of their formation. Under the assumption of LTE and in non-LTE calculations including the collisions only with electrons, the Al I 3961 ˚A resonance line gives a systematically lower abundance than the mean abundance from the subordinate lines, by 0.25-0.45 dex. The difference for each star is removed by taking into account the collisions with hydrogen atoms, and the rms error of the abundance derived from all seven Al I lines decreases by a factor of 1.5-3 compared to the LTE analysis. We have calculated the non- LTE corrections to the abundance for six subordinate Al I lines as a function of the effective temperature (4500 K ≤ T eff ≤ 6500 K), surface gravity (3.0 ≤ log g ≤ 4.5), and metal abundance ([M/H] = 0, -1, -2, and -3). For Si I including the collisions with HI leads to the establishment of equilibrium populations in the spectral line formation region even in hot metal-deficient models and to vanishingly small departures from LTE in spectral lines.

  19. Electronic structure and ground state properties of A4[Cu4O4] (A=Li, Na, K and Rb): A first principle study

    NASA Astrophysics Data System (ADS)

    Umamaheswari, R.; Yogeswari, M.; Kalpana, G.

    2012-06-01

    The results of first principles calculations of the electronic band structure and ground-state properties of alkali metal copper oxides A4[Cu4O4] (A = Li, Na, K and Rb) compounds are in tetragonal body centered structure with two different space groups I-4m2 and I4/mmm. The calculations have been carried out using the tight-binding linear muffin-tin orbital method within the local density approximation. The total energies calculated within the atomic sphere approximation where used to determine the ground-state properties such as equilibrium lattice parameters, c/a ratio, the bulk modulus and cohesive energy and these are found to be in good agreement with the available experimental values. The results of the electronic band structure calculations show that LiCuO, KCuO and RbCuO are indirect band gap semiconductors, whereas NaCuO is direct band gap semiconductor.

  20. Structural and Electrochemical Investigation of Li(Ni0.4Co0.2-yAlyMn0.4)O2 Cathode Material

    SciTech Connect

    Rumble, C.; Conry, T.E.; Doeff, Marca; Cairns, Elton J.; Penner-Hahn, James. E.; Deb, Aniruddha

    2010-02-02

    Li(Ni{sub 0.4}Co{sub 0.2-y}Al{sub y}Mn{sub 0.4})O{sub 2} with y=0.05 was investigated to understand the effect of replacement of the cobalt by aluminum on the structural and electrochemical properties. The effect of the substitution was studied by in-situ X-ray absorption spectroscopy (XAS), utilizing a novel in situ electrochemical cell, specifically designed for long-term X-ray experiments. The cell was cycled at a moderate rate through a typical Li-ion battery operating voltage range (1.0-4.7 V). XAS measurements were performed at different states-of-charge (SOC) during cycling, at the Ni, Co, and the Mn edges, revealing details about the response of the cathode to Li insertion and extraction processes. The extended X-ray absorption fine structure region of the spectra revealed the changes of bond distance and coordination number of Ni, Co, and Mn absorbers as a function of the SOC of the material. The oxidation states of the transition metals in the system are Ni{sup 2+}, Co{sup 3+}, and Mn{sup 4+} in the as-made material (fully discharged), while during charging the Ni{sup 2+} is oxidized to Ni{sup 4+} through an intermediate stage of Ni{sup 3+}, Co{sup 3+} is oxidized towards Co{sup 4+} and Mn was found to be electrochemically inactive and remains as Mn{sup 4+}. The EXAFS results during cycling show that the Ni-O changes the most, followed by Co-O and Mn-O varies the least. These measurements on this cathode material confirmed that the material retains its symmetry and good structural short-range order leading to the superior cycling reported earlier.

  1. Structural and electrochemical Investigation of Li(Ni0.4Co0.2-yAlyMn0.4)O2 Cathode Material

    SciTech Connect

    Rumble, C.; Conry, T.E.; Doeff, Marca; Cairns, Elton J.; Penner-Hahn, James E.; Deb, Aniruddha

    2010-06-14

    Li(Ni{sub 0.4}Co{sub 0.15}Al{sub 0.05}Mn{sub 0.4})O{sub 2} was investigated to understand the effect of replacement of the cobalt by aluminum on the structural and electrochemical properties. In situ X-ray absorption spectroscopy (XAS) was performed, utilizing a novel in situ electrochemical cell, specifically designed for long-term X-ray experiments. The cell was cycled at a moderate rate through a typical Li-ion battery operating voltage range. (1.0-4.7 V) XAS measurements were performed at different states of charge (SOC) during cycling, at the Ni, Co, and the Mn edges, revealing details about the response of the cathode to Li insertion and extraction processes. The extended X-ray absorption fine structure (EXAFS) region of the spectra revealed the changes of bond distance and coordination number of Ni, Co, and Mn absorbers as a function of the SOC of the material. The oxidation states of the transition metals in the system are Ni{sup 2+}, Co{sup 3+}, and Mn{sup 4+} in the as-made material (fully discharged), while during charging the Ni{sup 2+} is oxidized to Ni{sup 4+} through an intermediate stage of Ni{sup 3+}, Co{sup 3+} is oxidized toward Co{sup 4+}, and Mn was found to be electrochemically inactive and remained as Mn{sup 4+}. The EXAFS results during cycling show that the Ni-O changes the most, followed by Co-O, and Mn-O varies the least. These measurements on this cathode material confirmed that the material retains its symmetry and good structural short-range order leading to the superior cycling reported earlier.

  2. Development of Chromatographic Fingerprints of Eurycoma longifolia (Tongkat Ali) Roots Using Online Solid Phase Extraction-Liquid Chromatography (SPE-LC).

    PubMed

    Zaini, Nor Nasriah; Osman, Rozita; Juahir, Hafizan; Saim, Norashikin

    2016-04-30

    E. longifolia is attracting interest due to its pharmacological properties and pro-vitality effects. In this study, an online SPE-LC approach using polystyrene divinyl benzene (PSDVB) and C18 columns was developed in obtaining chromatographic fingerprints of E. longifolia. E. longifolia root samples were extracted using pressurized liquid extraction (PLE) technique prior to online SPE-LC. The effects of mobile phase compositions and column switching time on the chromatographic fingerprint were optimized. Validation of the developed method was studied based on eurycomanone. Linearity was in the range of 5 to 50 µg∙mL(-1) (r² = 0.997) with 3.2% relative standard deviation of peak area. The developed method was used to analyze 14 E. longifolia root samples and 10 products (capsules). Selected chemometric techniques: cluster analysis (CA), discriminant analysis (DA), and principal component analysis (PCA) were applied to the fingerprint datasets of 37 selected peaks to evaluate the ability of the chromatographic fingerprint in classifying quality of E. longifolia. Three groups were obtained using CA. DA yielded 100% correlation coefficient with 19 discriminant compounds. Using PCA, E. longifolia root samples were clearly discriminated from the products. This study showed that the developed online SPE-LC method was able to provide comprehensive evaluation of E. longifolia samples for quality control purposes.

  3. JGME-ALiEM Hot Topics in Medical Education Online Journal Club: An Analysis of a Virtual Discussion About Resident Teachers

    PubMed Central

    Sherbino, Jonathan; Joshi, Nikita; Lin, Michelle

    2015-01-01

    Background  In health professionals' education, senior learners play a key role in the teaching of junior colleagues. Objective  We describe an online discussion about residents as teachers to highlight the topic and the online journal club medium. Methods  In January 2015, the Journal of Graduate Medical Education (JGME) and the Academic Life in Emergency Medicine blog facilitated an open-access, online, weeklong journal club on the JGME article “What Makes a Great Resident Teacher? A Multicenter Survey of Medical Students Attending an Internal Medicine Conference.” Social media platforms used to promote asynchronous discussions included a blog, a video discussion via Google Hangouts on Air, and Twitter. We performed a thematic analysis of the discussion. Web analytics were captured as a measure of impact. Results  The blog post garnered 1324 page views from 372 cities in 42 countries. Twitter was used to endorse discussion points, while blog comments provided opinions or responded to an issue. The discussion focused on why resident feedback was devalued by medical students. Proposed explanations included feedback not being labeled as such, the process of giving delivery, the source of feedback, discrepancies with self-assessment, and threats to medical student self-image. The blog post resulted in a crowd-sourced repository of resident teacher resources. Conclusions  An online journal club provides a novel discussion forum across multiple social media platforms to engage authors, content experts, and the education community. Crowd-sourced analysis of the resident teacher role suggests that resident feedback to medical students is important, and barriers to student acceptance of feedback can be overcome. PMID:26457152

  4. Correlation between extravascular lung water and oxygenation in ALI/ARDS patients in septic shock: possible role in the development of atelectasis?

    PubMed

    Szakmany, T; Heigl, P; Molnar, Z

    2004-04-01

    This study aimed to evaluate the relationship between PaO2/FiO2 ratio and extravascular lung water in septic shock-induced acute respiratory distress syndrome in a prospective observational clinical trial. Twenty-three patients suffering from sepsis induced acute respiratory distress syndrome were recruited. All patients were ventilated in pressure control/support mode. Haemodynamic parameters were determined by arterial thermodilution (PiCCO) eight hourly for 72 hours. At the same time blood gas analyses were done and respiratory parameters were also recorded. Data are presented as mean +/-SD. For statistical analysis Pearson's correlation test, and analysis of variance (ANOVA) was used respectively. Significant negative correlation was found between extravascular lung water and PaO2/FiO2 (r = -0.355, P < 0.001), and significant positive correlation was shown between extravascular lung water and PEEP (r=0.557, P<0.001). A post-hoc analysis was performed when "low" PEEP: < 10 cmH2O and "high" PEEP: (10 cmH2O PEEP was applied, and neither the oxygenation, nor the driving pressure or the PaCO2 differed significantly, but the extravascular lung water showed significant difference when "high" or "low" PEEP was applied (13+/-5 vs 9+/-2 ml/kg respectively, P=0.001). This study found significant negative correlation between extravascular lung water and PaO2/FiO2. The mechanism by which extravascular lung water affects oxygenation is unknown but the significant positive correlation between PEEP and extravascular lung water shown in this trial suggests that the latter may have a role in the development of alveolar atelectasis.

  5. 78 FR 20339 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Docket No. FEMA-B-1301, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and....Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management...=2 New Orleans/Orleans Parish Orleans Parish Civil District Courthouse, 421 Loyola Avenue, Suite 402...

  6. 78 FR 20341 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Docket No. FEMA-B-1303, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and....Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management... the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a). These proposed...

  7. 76 FR 70403 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ..., identified by Docket No. FEMA-B-1227, to Luis Rodriguez, Chief, Engineering Management Branch, Federal..., DC 20472, (202) 646-4064, or (email) Luis.Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration...

  8. Materials for Adaptive Structural Acoustic Controls

    DTIC Science & Technology

    1994-01-31

    stannate -11M I f-I ic cmoiin MATERIALS FOR ADAPTIVE STRUCTURAL ACOUSTIC CONTROLS Period February 1, 1993 to January 31, 1994 Annual Report VOLUME I OFFICE... ics 139, 25- 49(1993). 14. Jiang, Q., W. Cao, and L. E. Cross. Electrical Fatigue in Lead Zirconate Titanate Ceramics. J. Am. Ceram. Soc. 77(1), 211...Ceramic Composte Transducer-The Moonie. Ferroelecuics: IM , Gaithersburg, Maryland (August 1993). 21. Tressler, J. F., Q. C. Xu, S. Yoshikawa, K. Uchino

  9. Internal Security Threats to Pakistan

    DTIC Science & Technology

    2004-12-01

    Niazi Qazi Hussain Ahmed Mln Fazlur Rehman Mln Sami-ul-Haq Allam Ahsan llali Zahir Armed Militias Apparently none Hizb-ul-Mujahiddin...special tribute to Bannett Jones, Christopher Jaffrelot, Rodney W. Jones, P.W. Singer, John M . Olin, Stephen Philip Cohen, Jessica Stern, Riffat... Hussain , Iftikhar H. Malik, Shahid Javed Burki, Moonis Ahmar, and Ishrat Husain. I am also thankful to the Pakistan Army for giving me an opportunity

  10. Capacity fade of LiAlyNi1-x-yCoxO2 cathode for lithium-ion batteries during accelerated calendar and cycle life tests (surface analysis of LiAlyNi1-x-yCoxO2 cathode after cycle tests in restricted depth of discharge ranges)

    NASA Astrophysics Data System (ADS)

    Watanabe, Shoichiro; Kinoshita, Masahiro; Hosokawa, Takashi; Morigaki, Kenichi; Nakura, Kensuke

    2014-07-01

    Cycle performance at 60 °C for a Li Al0.10Ni0.76Co0.14O2 (NCA) cathode/graphite cell was greatly improved when a DOD range in charge-discharge cycling (ΔDOD) was restricted. The deterioration mechanism was analyzed by X-ray photoelectron spectroscopy (XPS), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) and scanning transmission electron microscopy-electron energy-loss spectroscopy (STEM-EELS). Only after the cycle test in the ΔDOD of 0-100%, many micro-cracks were generated in the inter-surface between the primary particles which aggregated to form the secondary particles, and a NiO-like resistance layer with Fm3m rock salt structure was formed on each primary particle which was contact with other primary particles and electrolyte. It can be concluded that the lack of contact between the primary particles with the micro-crack generation and the formation of the new resistance layer are responsible for the capacity fading and the rise in impedance during charge-discharge cycle in the wide ΔDOD.

  11. Supreme Court of the United States Syllabus: San Antonio Independent School District Et. Al. v. Rodriguez Et. Al. Appeal from the United States District Court for the Western District of Texas. No. 71-1332, Argued October 12, 1972 -- Decided March 21, 1973.

    ERIC Educational Resources Information Center

    Supreme Court of the U. S., Washington, DC.

    In this landmark educational finance opinion (presented here in full) the U.S. Supreme Court held that the Texas case was not a proper case in which to examine a State's laws under standards of strict judicial scrutiny. That test, according to the Court, is reserved for cases involving laws that operate to the disadvantage of suspect classes or…

  12. 75 FR 36782 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ...) (individual) 2. MONDRAGON DE RODRIGUEZ, Mariela, c/o MARIELA DE RODRIGUEZ Y CIA. S. EN C., Cali, Colombia; c/o.../o INVERSIONES MONDRAGON Y CIA. S.C.S., Cali, Colombia; c/o MARIELA MONDRAGON DE R. Y CIA. S. EN C... Y CIA. LTDA., Cali, Colombia; c/o M. RODRIGUEZ O. Y CIA. S. EN C., Cali, Colombia; c/o...

  13. Improving the Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells.

    PubMed

    Tachibana, Ryo; Terai, Takuya; Boncompain, Gaelle; Sugiyama, Shigeru; Saito, Nae; Perez, Franck; Urano, Yasuteru

    2017-02-16

    Chemical inducers that can control target-protein localization in living cells are powerful tools to investigate dynamic biological systems. We recently reported the retention using selective hook or "RUSH" system for reversible localization change of proteins of interest by addition/washout of small-molecule artificial ligands of streptavidin (ALiS). However, the utility of previously developed ALiS was restricted by limited solubility in water. Here, we overcame this problem by X-ray crystal structure-guided design of a more soluble ALiS derivative (ALiS-3), which retains sufficient streptavidin-binding affinity for use in the RUSH system. The ALiS-3-streptavidin interaction was characterized in detail. ALiS-3 is a convenient and effective tool for dynamic control of α-mannosidase II localization between ER and Golgi in living cells. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. 78 FR 36098 - Final Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... 13132. Executive Order 12988, Civil Justice Reform. This final rule meets the applicable standards of...

  15. 78 FR 43202 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... 79th Avenue, Doral, FL 33178, Officers: Anamar Del Castillo, Vice President (QI), Jesus Cachazo..., FL 33122, Officers: Dorian F. Rodriguez, President (QI), Doris Del Castillo, Secretary, Application...

  16. 78 FR 32679 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  17. 78 FR 14316 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  18. 78 FR 36216 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  19. 78 FR 36220 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  20. 78 FR 14318 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  1. 78 FR 20337 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  2. 77 FR 66555 - Final Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... Bridge Road. Mud Creek West (backwater effects from From the Missouri River +569 Unincorporated Areas...

  3. 78 FR 34116 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...). of Ascension Parish Martinez, President, President's Office, (11-06-4231P). Ascension Parish, 208 208...

  4. An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.

    PubMed

    Zhong, Huailing; Hansen, Kasper B; Boyle, Noel J; Han, Kiho; Muske, Galina; Huang, Xinyan; Egebjerg, Jan; Sánchez, Connie

    2009-10-25

    The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the interaction of these two compounds at a low affinity allosteric binding site of hSERT can affect the dissociation of [(3)H]escitalopram from hSERT. The allosteric binding site involves a series of residues in the 10th, 11th, and 12th trans-membrane domains of hSERT. The low affinity allosteric activities of escitalopram and R-citalopram are essentially eliminated in a mutant hSERT with changes in some of these residues, namely A505V, L506F, I507L, S574T, I575T, as measured in dissociation binding studies. We confirm that in association binding experiments, R-citalopram at clinically relevant concentrations reduces the association rate of [(3)H]escitalopram as a ligand to wild type hSERT. We demonstrate that the ability of R-citalopram to reduce the association rate of escitalopram is also abolished in the mutant hSERT (A505V, L506F, I507L, S574T, I575T), along with the expected disruption the low affinity allosteric function on dissociation binding. This suggests that the allosteric binding site mediates both the low affinity and higher affinity interactions between R-citalopram, escitalopram, and hSERT. Our data add an additional structural basis for the different efficacies of escitalopram compared to racemic citalopram reported in animal studies and clinical trials, and substantiate the hypothesis that hSERT has complex allosteric mechanisms underlying the unexplained in vivo activities of its inhibitors.

  5. On the crystal energy and structure of A{sub 2}Ti{sub n}O{sub 2n+1} (A=Li, Na, K) titanates by DFT calculations and neutron diffraction

    SciTech Connect

    Catti, Michele; Pinus, Ilya; Scherillo, Antonella

    2013-09-15

    First-principles quantum-mechanical calculations (CRYSTAL09 code, B3LYP functional) were performed on alkali titanates A{sub 2}Ti{sub n}O{sub 2n+1} with layered structure (n=3,4,6). Monoclinic structural types with unshifted (P2{sub 1}/m) and with shifted (C2/m) layers were considered. Crystal energies and full structural details were obtained for all Li, Na, and K phases. Neutron diffraction data were collected on powder samples of P2{sub 1}/m-Li{sub 2}Ti{sub 3}O{sub 7} (a=9.3146(3), b=3.7522(1), c=7.5447(3) Å, β=97.611(4)°) and C2/m-K{sub 2}Ti{sub 4}O{sub 9} (a=18.2578(8), b=3.79160(9), c=12.0242(4) Å, β=106.459(4)°) and their structures were Rietveld-refined. Computed energies show the P2{sub 1}/m arrangement as favoured over the C2/m one for n=3, and the opposite holds for n=6. In the n=4 case the P2{sub 1}/m configuration is predicted to be more stable for Li and Na, and the C2/m one for K titanates. Analysis of Li–O and K–O crystal-chemical environments from experiment and theory shows that the alkali atom bonding is stabilized/destabilized in the different phases consistently with the energy trend. - Graphical abstract: Display Omitted - Highlights: • The P2{sub 1}/m structure-type is found to be more stable for A{sub 2}Ti{sub 3}O{sub 7} layer titanates. • The C2/m structure-type is found to be more stable for A{sub 2}Ti{sub 6}O{sub 13} layer titanates. • Tetratitanates are predicted to prefer the P2{sub 1}/m (Li and Na) or C2/m (K) structure. • Li–O and K–O bond distances follow a trend consistent with computed phase energies.

  6. Analyses par diffraction de rayons X sur des revêtements barrières thermiques réalisés par un procédé hybride plasma-laser

    NASA Astrophysics Data System (ADS)

    Antou, G.; Hlawka, F.; Montavon, G.; Bach, M.; Cornet, A.; Coddet, C.

    2004-11-01

    Les revêtements barrières thermiques (BTs) constitués de zircone yttriée partiellement stabilisée (ZrO{2} + 7% en masse d'Y{2}O{3}) et d'une sous-couche métallique (MCrAlY où M représente une combinaison de nickel et de cobalt) sont extrêmement utilisés afin d'améliorer les performances des composants des parties chaudes des turbines à gaz. La projection plasma sous atmosphère ambiante et l'irradiation laser in situ (au moyen d'un laser à diodes) sont associés ici afin de modifier les caractéristiques structurales des BTs. Les phases présentes au sein de la BT ont un rôle important. Des analyses par diffraction de rayons X ont été menées pour étudier les changements de phase possibles après traitement laser. Aucun changement de phase n'a été remarqué : la phase tétragonale métastable (t') demeure la phase prépondérante aussi bien pour les dépôts projetés que les dépôts post-traités au laser et refondus in situ. La formation de cette phase semble être liée à la solidification et au refroidissement rapide découlant de la projection plasma ainsi que de la refusion laser. Ce résultat est prometteur, car :

  7. Double stars measurements with cheap CCD sensors (French Title: Mesures d'étoiles doubles visuelles réalisées à l'aide de capteurs dtc de grande diffusion)

    NASA Astrophysics Data System (ADS)

    Losse, F.

    2005-09-01

    This paper presents 262 measurements of visual binaries. They essentially come from a three years evaluation period of cheap CCD sensors coupled with either off the shelves or modified webcam electronics. The evaluation cycle and results are largely described in Bulletin n°40 de la Commission des Etoiles Doubles (Sept. 2002 - Société Astronomique de France). These devices can produce measurements as consistent as those obtained with a filar micrometer on the same 8" telescope. The most recent measurements (epoch 2004+) were obtained with an "Audine" camera shipped with a KAF400. Besides the stars visited for evaluation purpose, we present some systems of interest : 17 orbital binaries, 35 neglected systems, 15 confirmations and 2 discoveries of a third component in already known systems.

  8. One-Time Treatment for Incidental Vocabulary Learning: Call for Discontinuation. A Commentary on Ali Karakas and Arif Sariçoban's "The Impact of Watching Subtitled Animated Cartoons on Incidental Vocabulary Learning of ELT Students"

    ERIC Educational Resources Information Center

    Bogdanov, Stan

    2013-01-01

    Incidental vocabulary learning has attracted a great deal of attention in ELT research. However, it is important that teacher and researcher exploitation of vocabulary developments be guided by more than replication of previous research designs. For conclusions based on empirical research to be valid, it is important to be clear about exactly what…

  9. Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors.

    PubMed

    de Fine Licht, Sofie; Rugbjerg, Kathrine; Gudmundsdottir, Thorgerdur; Bonnesen, Trine G; Asdahl, Peter Haubjerg; Holmqvist, Anna Sällfors; Madanat-Harjuoja, Laura; Tryggvadottir, Laufey; Wesenberg, Finn; Hasle, Henrik; Winther, Jeanette F; Olsen, Jørgen H

    2017-05-01

    Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943-2008 in Denmark, 1971-2008 in Finland, 1955-2008 in Iceland, and 1958-2008 in Sweden. We randomly selected 152,231 population comparison individuals matched by age, sex, year, and country (or municipality in Sweden) from the national population registers. Using a cohort design, study participants were followed in the national hospital registers in Denmark, 1977-2010; Finland, 1975-2012; Iceland, 1999-2008; and Sweden, 1968-2009. Disease-specific hospitalisation rates in survivors and comparison individuals were used to calculate survivors' standardised hospitalisation rate ratios (RRs), absolute excess risks (AERs), and standardised bed day ratios (SBDRs) based on length of stay in hospital. We adjusted for sex, age, and year by indirect standardisation. During 336,554 person-years of follow-up (mean: 16 years; range: 0-42 years), childhood cancer survivors experienced 21,325 first hospitalisations for diseases in one or more of 120 disease categories (cancer recurrence not included), when 10,999 were expected, yielding an overall RR of 1.94 (95% confidence interval [95% CI] 1.91-1.97). The AER was 3,068 (2,980-3,156) per 100,000 person-years, meaning that for each additional year of follow-up, an average of 3 of 100 survivors were hospitalised for a new excess disease beyond the background rates. Approximately 50% of the excess hospitalisations were for diseases of the nervous system (19.1% of all excess hospitalisations), endocrine system (11.1%), digestive organs (10.5%), and respiratory system (10.0%). Survivors of all types of childhood cancer were at increased, persistent risk for subsequent hospitalisation, the highest risks being those of survivors of neuroblastoma (RR: 2.6 [2.4-2.8]; n = 876), hepatic tumours (RR: 2.5 [2.0-3.1]; n = 92), central nervous system tumours (RR: 2.4 [2.3-2.5]; n = 6,175), and Hodgkin lymphoma (RR: 2.4 [2.3-2.5]; n = 2,027). Survivors spent on average five times as many days in hospital as comparison individuals (SBDR: 4.96 [4.94-4.98]; n = 422,218). The analyses of bed days in hospital included new primary cancers and recurrences. Of the total 422,218 days survivors spent in hospital, 47% (197,596 bed days) were for new primary cancers and recurrences. Our study is likely to underestimate the absolute overall disease burden experienced by survivors, as less severe late effects are missed if they are treated sufficiently in the outpatient setting or in the primary health care system. Childhood cancer survivors were at increased long-term risk for diseases requiring inpatient treatment even decades after their initial cancer. Health care providers who do not work in the area of late effects, especially those in primary health care, should be aware of this highly challenged group of patients in order to avoid or postpone hospitalisations by prevention, early detection, and appropriate treatments.

  10. Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: A cohort study of 21,297 childhood cancer survivors

    PubMed Central

    Rugbjerg, Kathrine; Bonnesen, Trine G.; Holmqvist, Anna Sällfors; Madanat-Harjuoja, Laura; Wesenberg, Finn; Winther, Jeanette F.

    2017-01-01

    Background Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Methods and findings From the national cancer registers of Denmark, Finland, Iceland, and Sweden, we identified 21,297 5-year survivors of childhood cancer diagnosed with cancer before the age of 20 years in the periods 1943–2008 in Denmark, 1971–2008 in Finland, 1955–2008 in Iceland, and 1958–2008 in Sweden. We randomly selected 152,231 population comparison individuals matched by age, sex, year, and country (or municipality in Sweden) from the national population registers. Using a cohort design, study participants were followed in the national hospital registers in Denmark, 1977–2010; Finland, 1975–2012; Iceland, 1999–2008; and Sweden, 1968–2009. Disease-specific hospitalisation rates in survivors and comparison individuals were used to calculate survivors’ standardised hospitalisation rate ratios (RRs), absolute excess risks (AERs), and standardised bed day ratios (SBDRs) based on length of stay in hospital. We adjusted for sex, age, and year by indirect standardisation. During 336,554 person-years of follow-up (mean: 16 years; range: 0–42 years), childhood cancer survivors experienced 21,325 first hospitalisations for diseases in one or more of 120 disease categories (cancer recurrence not included), when 10,999 were expected, yielding an overall RR of 1.94 (95% confidence interval [95% CI] 1.91–1.97). The AER was 3,068 (2,980–3,156) per 100,000 person-years, meaning that for each additional year of follow-up, an average of 3 of 100 survivors were hospitalised for a new excess disease beyond the background rates. Approximately 50% of the excess hospitalisations were for diseases of the nervous system (19.1% of all excess hospitalisations), endocrine system (11.1%), digestive organs (10.5%), and respiratory system (10.0%). Survivors of all types of childhood cancer were at increased, persistent risk for subsequent hospitalisation, the highest risks being those of survivors of neuroblastoma (RR: 2.6 [2.4–2.8]; n = 876), hepatic tumours (RR: 2.5 [2.0–3.1]; n = 92), central nervous system tumours (RR: 2.4 [2.3–2.5]; n = 6,175), and Hodgkin lymphoma (RR: 2.4 [2.3–2.5]; n = 2,027). Survivors spent on average five times as many days in hospital as comparison individuals (SBDR: 4.96 [4.94–4.98]; n = 422,218). The analyses of bed days in hospital included new primary cancers and recurrences. Of the total 422,218 days survivors spent in hospital, 47% (197,596 bed days) were for new primary cancers and recurrences. Our study is likely to underestimate the absolute overall disease burden experienced by survivors, as less severe late effects are missed if they are treated sufficiently in the outpatient setting or in the primary health care system. Conclusions Childhood cancer survivors were at increased long-term risk for diseases requiring inpatient treatment even decades after their initial cancer. Health care providers who do not work in the area of late effects, especially those in primary health care, should be aware of this highly challenged group of patients in order to avoid or postpone hospitalisations by prevention, early detection, and appropriate treatments. PMID:28486495

  11. 76 FR 53082 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... submit comments, identified by Docket No. FEMA-B-1213, to Luis Rodriguez, Chief, Engineering Management... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

  12. 76 FR 20606 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ..., identified by Docket No. FEMA-B-1188, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

  13. 75 FR 81957 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... submit comments, identified by Docket No. FEMA-B-1166, to Luis Rodriguez, Chief, Engineering Management... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

  14. 76 FR 36044 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ..., identified by Docket No. FEMA-B-1197, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

  15. 76 FR 39800 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ..., identified by Docket No. FEMA-B-1202, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering ] Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988. List...

  16. Validation of Biomarkers of the Tumor Microenvironment

    DTIC Science & Technology

    2014-10-01

    A., Yao , H., Rahmatpanah, F., Xia, X. Q., Xu, Q., Pio, R., Turan, T., Koziol, J. A., Goodison, S., Carpenter, P., Wang-Rodriguez, J., Simoneau, A...Wang, Y., Skarecky, D., Sutton, M., Sawyers, A., Ruckle, H., Carpenter, P. M., Wang-Rodriguez, J., Jiang, J., Deng, M., Pan , C., Zhu, J. G., McLaren, C

  17. 78 FR 48880 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500 C Street SW., Washington, DC 20472, (202) 646-4064, or (email) Luis.Rodriguez3@fema.dhs....: B- City of Bloomfield (12- Mr. David Fuqua, 915 North 1st Street, June 10, 2013 350066 1313). 06...

  18. 77 FR 65843 - Proposed Flood Elevation Determinations for Montgomery County, Alabama and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ..., identified by Docket No. FEMA-B- 1223, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  19. 77 FR 55787 - Proposed Flood Elevation Determinations for Clay County, FL, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ..., identified by Docket No. FEMA-B- 1222, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  20. 77 FR 65842 - Proposed Flood Elevation Determinations for the Unincorporated Areas of Robeson County, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... submit comments, identified by Docket No. FEMA-B- 1171, to Luis Rodriguez, Chief, Engineering Management... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for the...

  1. 77 FR 66791 - Proposed Flood Elevation Determinations for Wicomico County, MD, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ..., identified by Docket No. FEMA-B- 1085, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  2. 77 FR 66790 - Proposed Flood Elevation Determinations for Madison County, AL and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ..., identified by Docket No. FEMA-B- 1189, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  3. 77 FR 55787 - Proposed Flood Elevation Determinations for Hampden County, MA, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... comments, identified by Docket No. FEMA-B- 1066, to Luis Rodriguez, Chief, Engineering Management Branch... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  4. 77 FR 76998 - Proposed Flood Elevation Determinations for Nobles County, MN, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... comments, identified by Docket No. FEMA-B- 1184, to Luis Rodriguez, Chief, Engineering Management Branch... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  5. 76 FR 9714 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ..., identified by Docket No. FEMA-B- 1170, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations AGENCY...

  6. 77 FR 59880 - Proposed Flood Elevation Determinations for Coos County, OR, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ..., identified by Docket No. FEMA-B- 1204, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  7. 78 FR 78808 - Proposed Flood Elevation Determinations for Pierce County, Washington, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... comments, identified by Docket No. FEMA-B- 7748, to Luis Rodriguez, Chief, Engineering Management Branch... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  8. 77 FR 58507 - Proposed Flood Elevation Determinations for the Unincorporated Areas of Highlands County, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... comments, identified by Docket No. FEMA-B- 1204, to Luis Rodriguez, Chief, Engineering Management Branch... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for the...

  9. 77 FR 66791 - Proposed Flood Elevation Determinations for Yakima County, WA, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ..., identified by Docket No. FEMA-B- 1233, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  10. 78 FR 29696 - Proposed Flood Elevation Determinations for Lake County, Illinois, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ..., identified by Docket No. FEMA-B- 1196, to Luis Rodriguez, Chief, Engineering Management Branch, Federal...: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  11. 78 FR 34014 - Proposed Flood Elevation Determinations for Bolivar County, Mississippi and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... comments, identified by Docket No. FEMA-B- 1178, to Luis Rodriguez, Chief, Engineering Management Branch... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  12. Answers to Inequity: An Analysis of the New School Finance.

    ERIC Educational Resources Information Center

    Berke, Joel S.

    This study of the fiscal, legal, and political dimensions of reform in American school finance responds to the challenge of San Antonio Independent School District vs. Rodriguez. The book focuses specifically on the State of Texas and the way in which injustices were analyzed for the landmark Rodriguez case. The book goes on to describe the role…

  13. Texas Public School Finance: Resolving the Issue. A Report.

    ERIC Educational Resources Information Center

    Spurgin, N. David

    Published prior to the U.S. Supreme Court decision on the case, this report puts into perspective the questions and problems before the State of Texas in resolving the issue raised by Rodriguez vs San Antonio. The document reviews the key elements of the decision in the Rodriguez case and considers alternative approaches that comply with the…

  14. Twisted Gastrulation as a BMP Modulator during Mammary Gland Development and Tumorigenesis

    DTIC Science & Technology

    2014-05-01

    Signalling 24:961-968 3. McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez- Galindo C, Wilson M, Xiong S, Lozano...Development. 2009; 23:1450–1460. [PubMed: 19528321] McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez- Galindo

  15. Bioluminescence Potential in the Transition Zone to Very Shallow Water (VSW)

    DTIC Science & Technology

    2008-01-01

    population genetics study of D. Iglesias-Rodriguez with Lingulodinium polyedrum (see Baker et al. 2008). 5 IMPACT/APPLICATION...used to collect a time series of samples for the population genetics study of D. Iglesias-Rodriguez with Lingulodinium polyedrum funded under ONR code

  16. How Could It Be? Calling for Science Curricula That Cultivate Morals and Values towards Other Animals and Nature

    ERIC Educational Resources Information Center

    Logan, Marianne R.; Russell, Joshua J.

    2016-01-01

    Can science curricula truly cultivate morals and values towards nature? This is the question that is raised by Carolina Castano Rodriguez in her critique of the new Australian Science curriculum. In this response to Castano Rodriguez's paper we ask two questions relating to: the influence of curricula on the relationships of children and other…

  17. A Historian Will Lead a Community College in the Bronx

    ERIC Educational Resources Information Center

    Mangan, Katherine

    2009-01-01

    In July 2009, Felix V. Matos Rodriguez will take over as president of Hostos Community College of the City University of New York, which in 1970 opened in a converted tire factory in the South Bronx to educate members of a primarily Puerto Rican community. Like Mr. Matos Rodriguez, who moved to the mainland United States at age 18, many of those…

  18. How Could It Be? Calling for Science Curricula That Cultivate Morals and Values towards Other Animals and Nature

    ERIC Educational Resources Information Center

    Logan, Marianne R.; Russell, Joshua J.

    2016-01-01

    Can science curricula truly cultivate morals and values towards nature? This is the question that is raised by Carolina Castano Rodriguez in her critique of the new Australian Science curriculum. In this response to Castano Rodriguez's paper we ask two questions relating to: the influence of curricula on the relationships of children and other…

  19. 78 FR 37785 - Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Gerardo Domingo... Domingo Rodriguez-Rivera (``Rodriguez-Rivera'') was convicted of violating Section 38 of the ] Arms Export... convicted of knowingly and willfully exporting and causing to be exported and attempting to export and...

  20. A Historian Will Lead a Community College in the Bronx

    ERIC Educational Resources Information Center

    Mangan, Katherine

    2009-01-01

    In July 2009, Felix V. Matos Rodriguez will take over as president of Hostos Community College of the City University of New York, which in 1970 opened in a converted tire factory in the South Bronx to educate members of a primarily Puerto Rican community. Like Mr. Matos Rodriguez, who moved to the mainland United States at age 18, many of those…

  1. 75 FR 66138 - George Mathew, M.D.; Denial of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... business properties listed Abel Rodriguez as the registered agent for La Familia Pharmacy III, Inc. Id. at... Rodriguez's pharmacy, La Familia Pharmacy, to fill some of its prescriptions, and that that was how...-stamping' Dr. Mora's name to prescriptions filled by the La Familia group, even though he was not actually...

  2. Calculation of Vertical and Horizontal Mobilities in InAs/GaSb Superlattices (Postprint)

    DTIC Science & Technology

    2011-10-13

    Appl. Phys. Lett. 93, 041118 (2008). 10J. B. Rodriguez, C. Cervera , and P. Christol, Appl. Phys. Lett. 97, 251113 (2010). 11F. Aristone, J.-C. Portal, J...Chandrasekhar Rao, J. Antoszewski, L. Faraone, J. B. Rodriguez, E. Plis, and S. Krishna, ibid. 92, 012121 (2008); C. Cervera , J. B. Rodrigue, J. P. Perez

  3. 76 FR 21787 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... the attached certification involves the re-export of six (6) C-130 (E&H model) aircraft to the... the United States firm concerned. Sincerely, Miguel E. Rodriguez, Acting Assistant Secretary..., publication of which could cause competitive harm. Sincerely, Miguel E. Rodriguez, Acting Assistant Secretary...

  4. Pakistan’s Domestic Political Developments

    DTIC Science & Technology

    2005-09-19

    two parliamentary seats in the 1993 and 1997 elections). Notable Leaders of Pakistan Governor-General Mohammed Ali Jinnah 1947-1948 Prime Minister...Nation) Muhammed Ali Jinnah and his lieutenant, Liaquat Ali Khan, the PML was weakened upon their premature deaths in 1948 and 1951 ( Jinnah by natural...Liaquat Ali Khan 1947-1951 President Iskandar Ali Mirza 1955-1958 President-General Mohammed Ayub Khan 1958-1969 President-General Mohammed Yahya Khan

  5. An Alternative Method of Acute Lung Injury Classification for Use in Observational Studies

    PubMed Central

    Shah, Chirag V.; Lanken, Paul N.; Localio, A. Russell; Gallop, Robert; Bellamy, Scarlett; Ma, Shwu-Fan; Flores, Carlos; Kahn, Jeremy M.; Finkel, Barbara; Fuchs, Barry D.; Garcia, Joe G. N.

    2010-01-01

    Background: In observational studies using acute lung injury (ALI) as an outcome, a spectrum of lung injury and difficult-to-interpret chest radiographs (CXRs) may hamper efforts to uncover risk factor associations. We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on clinical and genetic risk factor associations for ALI after trauma. Methods: This study was of a prospective cohort of 280 critically ill trauma patients. The primary outcome was the development of ALI. Patients were classified into one of three groups: (1) definite ALI (patients who fulfilled the American-European Consensus Conference [AECC] criteria for ALI), (2)equivocal ALI (patients who had difficult-to-interpret CXRs), and (3) definite non-ALI. We compared clinical and genetic ALI risk factor associations between two classification schemes: AECC classification (definite ALI vs rest) and alternative classification (definite ALI vs definite non-ALI, excluding equivocal ALI). Results: Ninety-three (35%) patients were classified as definite ALI, 67 (25%) as equivocal, and 104 (39%) as definite non-ALI. Estimates of clinical and genetic ALI risk factor associations were farther from the null using the alternative classification. In a multivariable risk factor model, the C statistic of the alternative classification was significantly higher than that derived from the AECC classification (0.82 vs 0.74; P < .01). Conclusions: The ability to detect ALI risk factors may be improved by excluding patients with equivocal or difficult-to-classify ALI. Such analyses may provide improved ability to detect clinical and genetic risk factor associations in future epidemiologic studies of ALI. PMID:20576730

  6. Laser Temperature-Jump Kinetic Studies of Fast Reactions in Nonaqueous Solutions

    DTIC Science & Technology

    1990-02-28

    Rose, E. N. Eyring, L. J. Rodriguez, and S. Petrucci , J. Phys. Chem. 21, 1396 (1989). 2. L. J. Rodriguez, M. Xu, E. M. Eyring and S. Petrucci , Pure...Appl. Chem. §1 , 1593 (1989). 3. J. Eschmann, J. Strasser, M. Xu, Y. Okamoto, E. H. Eyring and S. Petrucci , J. Phys. Chem., in press. 4. B. A...Barton, D. J. Rose, E. H. Eyring, L. J. Rodriguez, and S. Petrucci , "Kinetics of Complexation of Lithium Perchlorate with 18-Crown-6 in Propylene

  7. 76 FR 62329 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... of Brock Bridge Road. Marley Creek Approximately 485 feet + 8 + 7 Unincorporated Areas of upstream of...) for exact locations of all BFEs to be changed. Send comments to Luis Rodriguez, Chief, Engineering...

  8. 78 FR 37850 - Quality Assurance Program Requirements (Operations)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Rodriguez-Luccioni Regulatory Guide Development Branch, Division of Engineering, Office of Nuclear..., Chief, Regulatory Guide Development Branch, Division of Engineering, Office of Nuclear Regulatory... From the Federal Register Online via the Government Publishing Office NUCLEAR...

  9. 76 FR 44462 - Statement of General Policy or Interpretation; Commentary on the Fair Credit Reporting Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... assist consumers and businesses in combating identity theft and reducing the damage to consumers when... INFORMATION CONTACT: Anthony Rodriguez, (202) 326-2757, Division of Privacy and Identity Protection, Bureau...

  10. 75 FR 81889 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... modifications are made pursuant to section 201 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4105,...

  11. Comment on ''Casimir-Polder potential in a dielectric medium out of thermal equilibrium''

    SciTech Connect

    Milonni, Peter W.

    2011-10-15

    Rodriguez and Salam [Phys. Rev. A 82, 062522 (2010)] find disagreement between their results for the temperature dependence of the Casimir-Polder potential and those of earlier publications. It is argued that the latter are correct.

  12. 78 FR 14737 - Proposed Flood Elevation Determinations for Sussex County, Delaware, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ..., Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency....dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations for...

  13. 77 FR 50667 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ...-B- 1104, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations AGENCY...

  14. 76 FR 43637 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations AGENCY...

  15. 77 FR 55784 - Proposed Flood Elevation Determinations; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations; Correction AGENCY: Federal Emergency Management Agency, DHS. ACTION: Proposed rule; correction. SUMMARY: On...

  16. 78 FR 78992 - Proposed Flood Hazard Determinations for Plaquemines Parish, Louisiana and Incorporated Areas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations for Plaquemines Parish... Emergency Management Agency, DHS. ACTION: Notice; withdrawal. SUMMARY: The Federal Emergency Management...

  17. 78 FR 22221 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    .... FEMA-B- 1212, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations AGENCY...

  18. 76 FR 26980 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations AGENCY: Federal Emergency Management Agency, DHS. ACTION: Proposed rule; correction. SUMMARY: On November 9, 2010...

  19. 78 FR 8089 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    .... FEMA-B- 1233, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management...

  20. 77 FR 50665 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ...-B- 1127, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management..., Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal Emergency Management...

  1. Rodriquez and Friends

    ERIC Educational Resources Information Center

    Mathews, Linda

    1973-01-01

    Recounts the now-famous Supreme Court case, San Antonio Independent School District versus Rodriguez, relating to the proposition that wealth-based inequities in school spending are unconstitutional. (RJ)

  2. 78 FR 56993 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ...); Gary D. Hallman (AL); Edward J. Kasper (DE); Jorge Lopez (OH); Robert D. Porter (CA); Robert A. Reyna.... Raymond (FL); J. Bernardo Rodriguez (TX); Lee T. Taylor (FL). The exemptions are extended subject to...

  3. 78 FR 32701 - Hours of Service of Drivers: Trailways Companies Application for Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... picking up or discharging passengers, baggage and/or package express items.'' Ms. Veronica Rodriguez said... license plate number, e. Number of individuals suffering physical injury, f. Number of fatalities, g....

  4. The Real Issue: Need for Tax Reform

    ERIC Educational Resources Information Center

    Hall, David

    1973-01-01

    The Rodriguez decision simply points up the fact that the answer to unequal educational opportunity is not to be found in the federal constitution but in the reform of property assessment and property taxation. (Author/JN)

  5. 76 FR 75543 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ..., Implementation, San Diego County, CA, Comment Period Ends: 01/17/2012, Contact: Jesse Martinez (619) 532-3844... National Forest, Clearwater County, ID, Review Period Ends: 01/03/2012, Contact: Kathy Rodriguez (208) 476...

  6. Latin America Report No. 2689.

    DTIC Science & Technology

    2007-11-02

    officers against not so much the person of Alfredo Stroessner as against the main people around him, including his son Gustavo Stroessner. As far as we can...domestic and foreign companies involved in the project. According to our sources, these figures include Gustavo Stroessner and Generals Andres Rodriguez... Gustavo , who has been singled out as the main partner of not only De Bernardi and General Rodriguez but also (and this is more serious) of the famous

  7. Neoplasms of the Stomach, Liver & Pancreas: Prevention, Diagnosis, and Treatment among High-Risk Populations | Division of Cancer Prevention

    Cancer.gov

    Agenda - Day 1, September 18, 2015 08:00 am - Registration 08:30 am - Welcome remarks and overview of the Conference Dr. Leslie Ford (NCI) – 5 min Dr. Edgar Colon (RCM and UPRCCC) - 5 min Luz Maria Rodriguez – Conference objectives & structure  Global Cancer Burden: An Overview and State of the Problem Moderators: Dr. Luz Maria Rodriguez and Dr. Victor Jose Carlo (PR Gastroenterology Association) |

  8. Development of a Suite of Luciferase Gene Probes for the Screening and Detection of Marine Bioluminescent Systems and Organisms

    DTIC Science & Technology

    2006-01-01

    a novel tool for high resolution population genetic studies (Frommlet and Iglesias- Rodriguez, in review, J. Phycology ). Development of luciferase...approach to assess dinoflagellate population structure, J. Phycology . 5 Baker, A., Robbins, I., Moline, M.A. and Iglesias-Rodriguez, M.D... Phycological Congress, Oviedo, Spain, 22-27 July 2007. 6 Table 1: Stations sampled on the Ellett line during the D321b cruise to the North Atlantic

  9. Solubility of RDX, PETN and Boric Acid in Methylene Chloride

    DTIC Science & Technology

    2010-08-01

    Solubility of RDX, PETN, and Boric Acid in Methylene Chloride by Rose Pesce-Rodriguez ARL-TN-0401 August 2010...of RDX, PETN, and Boric Acid in Methylene Chloride Rose Pesce-Rodriguez Weapons and Materials Research Directorate, ARL...AND SUBTITLE Solubility of RDX, PETN and Boric Acid in Methylene Chloride 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  10. Bioluminescence Potential in the Transition Zone to Very Shallow Water (VSW)

    DTIC Science & Technology

    2006-01-01

    communities. The sampler is also being used to collect a time series of samples for the population genetics study of D. Iglesias-Rodriguez with...Wetlabs UBAT sensor for bioluminescence measurements. 4- The profiler is also being used to collect a time series of samples for the population ... genetics study of D. Iglesias-Rodriguez with Lingulodinium polyedrum funded under ONR code 32 OB. 5 REFERENCES Blackwell, S., J. Case, S. Glenn, J

  11. A new species and new records of Cryptodacus (Diptera: Tephritidae) from Colombia, Bolivia and Peru.

    PubMed

    Rodriguez, Pedro Alexander; Rodriguez, Erick J; Norrbom, Allen L; Arévalo, Emilio

    2016-05-16

    Cryptodacus bernardoi Rodriguez & Rodriguez, new species, is described from Colombia. It was reared from fruits of Phoradendron sp. near piperoides (Kunth) Trel. New distribution records are reported for Cryptodacus ornatus Norrbom from Colombia and Peru, for Cryptodacus trinotatus Norrbom & Korytkowski from Colombia, and for Cryptodacus obliquus Hendel from Bolivia and Peru. The female abdomen and terminalia of C. obliquus is described for the first time. The Norrbom & Korytkowski (2008)`s key to species was modified to include C. bernardoi n. sp.

  12. A Survey of Missions for Unmanned Undersea Vehicles

    DTIC Science & Technology

    2009-01-01

    of underwater vehicles, a control system, remote consoles , communications modules, software, and support equipment. The Tal- isman program is fully...2006; S. M. Jesus and O. C. Rodriguez, “Glider Towed Array Tests During the Makai Experiment,” Pro- ceedings of the Eighth European Conference on...of California, Technical Report No. 53, 2003. Jesus , S. M., and O. C. Rodriguez, “Glider Towed Array Tests During the Makai Experiment,” Proceedings

  13. MM&T: Bibliography on Optical Testing with Appendix.

    DTIC Science & Technology

    1982-02-26

    I963-A ITI to TECHNICAL REPORT RH-CR-82-6’.-4 MM&T: BIBLIOGRAPHY ON OPTICAL TESTING WITH APPENDIX A. Comejo-Rodriguez Apdo..Postal 216 Puebla , Puebla ...34SCATTERING CHARACTERISTICS OF MIRRORS AND THE ASSOCIATED INVERSE SCATTERING PROBLEM" Ph.D. dissertation, University of California at Los Angeles (1973...OF OPTICAL SURFACES A. C rnejo Rodriguez )do. Postal 216 Puebla , Puebla , Mexico H. J. Caulfield Aerodyne Research, Inc. Bedford Research Park Crosby

  14. Reforming Mexico’s Energy Sector to Enhance Stability

    DTIC Science & Technology

    2011-10-27

    Congressional Research Service, September 9, 2011), 10. 5 Carlos Manuel Rodriguez, “Pemex’s Proved Oil Reserves Decline for 12th Year in a Row...ed. and Raul Delgado Wise, ed. Mexico’s Economic Dilemma: The Developmental Failure of Neoliberalism. New York: Rowman and Littlefield...Crime and Drug Cartels Top Concerns in Mexico. Global Attitudes Project, August 31, 2011. Rodriguez, Carlos Manuel . “Pemex’s Proved Oil Reserves

  15. Studies of Prostate Tumor Development via Cre/LoxP Technology

    DTIC Science & Technology

    2002-05-01

    in our facility and used routinely in our transgenic experiments (Robles et al., 1996; Rodriguez Puebla et al., 2000). Crosses with Rosa 26 mice have...In the case of K5-Cre we used the strategy used routinely in our laboratory with primers for the Globin intron (Rodriguez Puebla et al. 2000). In the... Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM. Metastatic prostate cancer in a transgenic mouse. Cancer

  16. Adaptive Gravitational Gossip in Monitoring the Joint Battlespace Infosphere

    DTIC Science & Technology

    2007-03-01

    GWCast by Hopkinson et al [3]. A project that is analogous to JBI efforts is the Network-friendly Epidemic Mul- ticast ( NEEM ) project, also by Rodriguez...21]. NEEM focuses on preserving bandwidth and keeping costs down on transmissions. These two qualities are what military commu- nicators are seeking...nodes or agents in the network medium chosen; one such example is using gossip in a WAN environment as tested by Rodriguez with NEEM [21]. With the

  17. Bronchoscopy-Derived Correlates of Lung Injury Following Inhalational Injuries: A Prospective Obervational Study

    EPA Science Inventory

    Acute lung injury (ALI) is a major factor determining morbidity following burns and inhalational injury. In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studi...

  18. Bronchoscopy-Derived Correlates of Lung Injury Following Inhalational Injuries: A Prospective Obervational Study

    EPA Science Inventory

    Acute lung injury (ALI) is a major factor determining morbidity following burns and inhalational injury. In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studi...

  19. Alginate lyases from alginate-degrading Vibrio splendidus 12B01 are endolytic.

    PubMed

    Badur, Ahmet H; Jagtap, Sujit Sadashiv; Yalamanchili, Geethika; Lee, Jung-Kul; Zhao, Huimin; Rao, Christopher V

    2015-03-01

    Alginate lyases are enzymes that degrade alginate through β-elimination of the glycosidic bond into smaller oligomers. We investigated the alginate lyases from Vibrio splendidus 12B01, a marine bacterioplankton species that can grow on alginate as its sole carbon source. We identified, purified, and characterized four polysaccharide lyase family 7 alginates lyases, AlyA, AlyB, AlyD, and AlyE, from V. splendidus 12B01. The four lyases were found to have optimal activity between pH 7.5 and 8.5 and at 20 to 25°C, consistent with their use in a marine environment. AlyA, AlyB, AlyD, and AlyE were found to exhibit a turnover number (kcat) for alginate of 0.60 ± 0.02 s(-1), 3.7 ± 0.3 s(-1), 4.5 ± 0.5 s(-1), and 7.1 ± 0.2 s(-1), respectively. The Km values of AlyA, AlyB, AlyD, and AlyE toward alginate were 36 ± 7 μM, 22 ± 5 μM, 60 ± 2 μM, and 123 ± 6 μM, respectively. AlyA and AlyB were found principally to cleave the β-1,4 bonds between β-d-mannuronate and α-l-guluronate and subunits; AlyD and AlyE were found to principally cleave the α-1,4 bonds involving α-l-guluronate subunits. The four alginate lyases degrade alginate into longer chains of oligomers.

  20. International Game 󈨧: Crisis in South Asia, 28-30 January 1999

    DTIC Science & Technology

    1999-01-01

    September 11) Mohammed Ali Jinnah dies. Liaquat Ali Khan becomes Governor General of Pakistan. India Department of Atomic Energy created. 1950... Ali Jinnah becomes leader of Muslim League. 1935 British pass “Government of India Act of 1935” expanding power of elected national and provincial... Mohammed Ali Bogra becomes leader of Pakistan. 1954 India signs friendship treaty with China. 1955 Pakistan Atomic Energy Commission set up to

  1. Alginate Lyases from Alginate-Degrading Vibrio splendidus 12B01 Are Endolytic

    PubMed Central

    Badur, Ahmet H.; Jagtap, Sujit Sadashiv; Yalamanchili, Geethika; Lee, Jung-Kul; Zhao, Huimin

    2015-01-01

    Alginate lyases are enzymes that degrade alginate through β-elimination of the glycosidic bond into smaller oligomers. We investigated the alginate lyases from Vibrio splendidus 12B01, a marine bacterioplankton species that can grow on alginate as its sole carbon source. We identified, purified, and characterized four polysaccharide lyase family 7 alginates lyases, AlyA, AlyB, AlyD, and AlyE, from V. splendidus 12B01. The four lyases were found to have optimal activity between pH 7.5 and 8.5 and at 20 to 25°C, consistent with their use in a marine environment. AlyA, AlyB, AlyD, and AlyE were found to exhibit a turnover number (kcat) for alginate of 0.60 ± 0.02 s−1, 3.7 ± 0.3 s−1, 4.5 ± 0.5 s−1, and 7.1 ± 0.2 s−1, respectively. The Km values of AlyA, AlyB, AlyD, and AlyE toward alginate were 36 ± 7 μM, 22 ± 5 μM, 60 ± 2 μM, and 123 ± 6 μM, respectively. AlyA and AlyB were found principally to cleave the β-1,4 bonds between β-d-mannuronate and α-l-guluronate and subunits; AlyD and AlyE were found to principally cleave the α-1,4 bonds involving α-l-guluronate subunits. The four alginate lyases degrade alginate into longer chains of oligomers. PMID:25556193

  2. Beyond Standards

    ERIC Educational Resources Information Center

    Sherlock, David

    2007-01-01

    In this article, the author reflects on his stay at Adult Learning Inspectorate (ALI) and on his life after it. ALI was not just a piece of the state bureaucracy, what some civil servants ironically insisted on describing as the "burden on providers." ALI had been a long time in the making and rested on some very solidly established ideas about…

  3. Standing Watch

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    Russlynn Ali, Assistant Secretary for Civil Rights at the Department of Education, is charged with enforcing a wide range of education equity laws. Ali was a passionate activist in California helping champion educational equity for minorities. Today, as Ali approaches her third year working as assistant secretary for civil rights, she says she has…

  4. Standing Watch

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    Russlynn Ali, Assistant Secretary for Civil Rights at the Department of Education, is charged with enforcing a wide range of education equity laws. Ali was a passionate activist in California helping champion educational equity for minorities. Today, as Ali approaches her third year working as assistant secretary for civil rights, she says she has…

  5. Piezoelectric and electrostrictive materials for transducers applications, volume 1

    NASA Astrophysics Data System (ADS)

    Cross, L. E.; Newnham, R. E.; Bhalla, A. S.; Dougherty, J. P.; Adair, J. H.; Varadan, V. K.; Varadan, V. V.

    1992-01-01

    Highlights of the past year's activities include: An increased emphasis upon the flextensional (moonie) type actuators, modeling both the internal stress distribution as a function of geometry, and the very interesting resonant mode structure of the composites; a more refined focus upon the performance of piezoelectric ceramic transducers, particularly under high drive levels is developing with concern for the extrinsic domain and phase boundary contributions to response. Measurement and modelling are being used to explore the nonlinearity and the frequency response and to examine the phase partitioning at the rhombohedral:tetragonal morphotropic phase boundary in the PZT system. Phenomena limiting lifetime in polarization and phase switching actuators are being explored to separate surface and volume effects and those due to grain size and flaw population differences. New work has been initiated to examine Acoustic Emission as a technique, in combination with Barkhausen current pulse analysis, to separate and evaluate domain switching and microcracking in polarization switching systems.

  6. NF-κB2 Controls Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in A Mouse Model of Sjögren's Syndrome.

    PubMed

    Kurosawa, Mie; Arakaki, Rieko; Yamada, Akiko; Tsunematsu, Takaaki; Kudo, Yasusei; Sprent, Jonathan; Ishimaru, Naozumi

    2017-08-13

    Dysregulated chemokine signaling contributes to autoimmune diseases by facilitating aberrant T-cell infiltration into target tissues, but the specific chemokines, receptors, and T-cell populations remain largely unidentified. Role of the potent chemokine CXCL12 and its receptor CXCR4 in T-cell autoimmune response was examined using alymphoplasia (aly)/aly mice, a Sjögren's syndrome (SS) model. T-cell phenotypes in the salivary gland of aly/aly mice were evaluated using immunological analysis. In vitro migration assay was used to assess T-cell migratory activity toward several chemokines. Gene expression of chemokine receptors, and transforming growth factor (TGF)β receptors was measured with quantitative reverse transcription-polymerase chain reaction. The CXCR4 antagonist AMD3100 was administered to the aly/aly mice to evaluate its suppressive effect on autoimmune lesions. Effector memory T (TEM) cells derived from aly/aly mice demonstrated higher in vitro migratory activity toward CXCL12 than aly/+ TEM cells. CXCL12 expression was specifically upregulated in the SS target cells of aly/aly mice. TEM cells from RelB(-/-) mice, but not nuclear factor (NF)-κB1(-/-) mice, also showed high migratory activity toward CXCL12, implicating a nonclassical NF-κB2/RelB pathway in the regulation of TEM cell migration. TEM cells from aly/aly mice also overexpressed TGFβ receptors I and II. The CXCR4 antagonist AMD3100 suppressed autoimmune lesions in aly/aly mice by reducing TEM cell infiltration. Our results suggest that the NF-κB2/RelB pathway regulates T-cell migration to autoimmune targets through TGFβ/TGFβR-dependent regulation of CXCL12-CXCR4 signaling. This suggests that these signaling pathways are potential therapeutic targets for treating autoimmune diseases. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  7. Crystal structure and optical property of complex perovskite oxynitrides ALi0.2Nb0.8O2.8N0.2, ANa0.2Nb0.8O2.8N0.2, and AMg0.2Nb0.8O2.6N0.4 (A = Sr, Ba)

    NASA Astrophysics Data System (ADS)

    Moon, Keon Ho; Avdeev, Maxim; Kim, Young-Il

    2017-10-01

    Oxynitride type complex perovskites AM0.2Nb0.8O3-xNx (A = Sr, Ba; M = Li, Na, Mg) were newly synthesized by the solid state diffusion of Li+, Na+, or Mg2+ into the layered oxide, A5Nb4O15, with concurrent O/N substitution. Neutron and synchrotron X-ray Rietveld refinement showed that SrLi0.2Nb0.8O2.8N0.2, SrNa0.2Nb0.8O2.8N0.2, and SrMg0.2Nb0.8O2.6N0.4 had body-centered tetragonal symmetry (I4/mcm), while those with A = Ba had simple cubic symmetry (Pm 3 ̅ m). In the tetragonal Sr-compounds, the nitrogen atoms were localized on the c-axial 4a site. However, the octahedral cations, M/Nb (M = Li, Na, Mg) were distributed randomly in all six compounds. The lattice volume of AM0.2Nb0.8O3-xNx was dependent on various factors including the type of A and the electronegativity of M. Compared to the simple perovskites, ANbO2N (A = Sr, Ba), AM0.2Nb0.8O3-xNx had wider band gaps (1.76-2.15 eV for A = Sr and 1.65-2.10 eV for A = Ba), but significantly lower sub-gap absorption.

  8. cis-trans Germanium chains in the intermetallic compounds ALi{sub 1-x}In{sub x}Ge{sub 2} and A{sub 2}(Li{sub 1-x}In{sub x}){sub 2}Ge{sub 3} (A=Sr, Ba, Eu)-experimental and theoretical studies

    SciTech Connect

    You, Tae-Soo; Bobev, Svilen

    2010-12-15

    Two types of strontium-, barium- and europium-containing germanides have been synthesized using high temperature reactions and characterized by single-crystal X-ray diffraction. All reported compounds also contain mixed-occupied Li and In atoms, resulting in quaternary phases with narrow homogeneity ranges. The first type comprises EuLi{sub 0.91(1)}In{sub 0.09}Ge{sub 2}, SrLi{sub 0.95(1)}In{sub 0.05}Ge{sub 2} and BaLi{sub 0.99(1)}In{sub 0.01}Ge{sub 2}, which crystallize in the orthorhombic space group Pnma (BaLi{sub 0.9}Mg{sub 0.1}Si{sub 2} structure type, Pearson code oP16). The lattice parameters are a=7.129(4)-7.405(4) A; b=4.426(3)-4.638(2) A; and c=11.462(7)-11.872(6) A. The second type includes Eu{sub 2}Li{sub 1.36(1)}In{sub 0.64}Ge{sub 3} and Sr{sub 2}Li{sub 1.45(1)}In{sub 0.55}Ge{sub 3}, which adopt the orthorhombic space group Cmcm (Ce{sub 2}Li{sub 2}Ge{sub 3} structure type, Pearson code oC28) with lattice parameters a=4.534(2)-4.618(2) A; b=19.347(8)-19.685(9) A; and c=7.164(3)-7.260(3) A. The polyanionic sub-structures in both cases feature one-dimensional Ge chains with alternating Ge-Ge bonds in cis- and trans-conformation. Theoretical studies using the tight-binding linear muffin-tin orbital (LMTO) method provide the rationale for optimizing the overall bonding by diminishing the {pi}-p delocalization along the Ge chains, accounting for the experimentally confirmed substitution of Li forIn. -- Graphical abstract: Presented are the single-crystal structures of two types of closely related intermetallics, as well as their band structures, calculated using tight-binding linear muffin-tin orbital (TB-LMTO-ASA) method. Display Omitted

  9. Examining the foreseeable: assisted suicide as a herald of changing moralities.

    PubMed

    Martel, J

    2001-06-01

    After her intense battle for the decriminalization of assisted suicide in the Supreme Court of Canada, Sue Rodriguez committed suicide with medical assistance in 1994. Following her suicide, government and law representatives remained silent and no criminal charges were ever brought against the person(s) who presumably assisted Ms Rodriguez in her death. This apparent non-intervention of criminal law is examined in view of the useful role that the Rodriguez event may have played in a possible shift in the dominant morality. It is argued that the Rodriguez assisted suicide may have been a useful 'crime' (in the Durkheimian sense) in that it brought to the fore the possibility that social conditions--which made the 'crime' possible--may no longer be in harmony with conventional morality. Similarly to Socrates' crime, the Rodriguez case can be seen as an anticipation of a new morality. It can be analyzed as a prelude to alterations, as directly preparing the way for changes in the dominant morality. The role of criminal law as a preferred mode of moral regulation is also examined in relation to the moral demands and expectations that arose during as well as after the judicial saga.

  10. Family 13 carbohydrate-binding module of alginate lyase from Agarivorans sp. L11 enhances its catalytic efficiency and thermostability, and alters its substrate preference and product distribution.

    PubMed

    Li, Shangyong; Yang, Xuemei; Bao, Mengmeng; Wu, Ying; Yu, Wengong; Han, Feng

    2015-05-01

    The carbohydrate-binding module (CBM) in polysaccharide hydrolases plays a key role in the hydrolysis of cellulose, xylan and chitin. However, the function of CBM in alginate lyases has not been elucidated. A new alginate lyase gene, alyL2, was cloned from the marine bacterium Agarivorans sp. L11 by using degenerate and site-finding PCR. The alginate lyase, AlyL2, contained an N-terminal CBM13 and a C-terminal catalytic family 7 polysaccharide lyase (PL7) module. To better understand the function of CBM13 in alginate lyase AlyL2, the full-length enzyme (AlyL2-FL) and its catalytic module (AlyL2-CM) were expressed in Escherichia coli and characterized. The specific activity and catalytic efficiency of AlyL2-FL were approximately twice those of AlyL2-CM. The half-lives of AlyL2-FL were 4.7-6.6 times those of AlyL2-CM at 30-50°C. In addition, the presence of CBM13 in AlyL2 changed its substrate preference and increased the percentage of disaccharides from 50.5% to 64.6% in the total products. This first report of the function of CBM13 in alginate lyase provides new insights into the degradation of alginate by marine microorganisms.

  11. Macrophage Migration Inhibitory Factor in Acute Lung Injury: Expression, Biomarker and Associations

    PubMed Central

    Gao, Li; Flores, Carlos; Ma, Shwu-Fan; Miller, Edmund J.; Moitra, Jaideep; Moreno, Liliana; Wadgaonkar, Raj; Simon, Brett; Brower, Roy; Sevransky, Jonathan; Tuder, Rubin M.; Maloney, James P.; Moss, Marc; Shanholtz, Carl; Yates, C. Ryan; Meduri, Gianfranco Umberto; Ye, Shui Q.; Barnes, Kathleen C.; Garcia, Joe G.N.

    2007-01-01

    Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine central to the response to endotoxemia, is a putative biomarker in acute lung injury (ALI). To explore MIF as a molecular target and candidate gene in ALI, we examined MIF gene and protein expression in murine and canine models of ALI (high tidal volume mechanical ventilation, endotoxin exposure) and in patients with either sepsis or sepsis-induced ALI. MIF gene expression and protein levels were significantly increased in each ALI model, with serum MIF levels significantly higher in patients with either sepsis or ALI compared to healthy controls (African- and European- descent). We next studied the association of 8 MIF gene polymorphisms (SNPs) (within a 9.7 kb interval on chromosome 22q11.23) with the development of sepsis and ALI in European- and African- descent populations. Genotyping in 506 DNA samples (sepsis patients, sepsis-associated ALI patients, and healthy controls) revealed haplotypes located in the 3′ end of the MIF gene, but not individual SNPs, associated with sepsis and ALI in both populations. These data, generated via functional genomic and genetic approaches, suggest that MIF is a relevant molecular target in ALI. PMID:17585860

  12. Protective effects of ethyl pyruvate on lipopolysaccharide-induced acute lung injury through inhibition of autophagy in neutrophils

    PubMed Central

    Zhu, Qingteng; Wang, Hui; Wang, Hairong; Luo, Yong; Yu, Yang; Du, Qirong; Fei, Aihua; Pan, Shuming

    2017-01-01

    Among a number of clinical factors, bacterial infection is one of the most common causes of acute lung injury (ALI), a serious complication that carries a high risk of mortality (~40%). During the process of ALI, intense local and systemic inflammation is elicited, which exacerbates the injury. Neutrophil infiltration into airspace is observed in early stage of ALI, and is required for the full development of ALI through an array of mechanisms, including the release of granule contents and the production of pro-inflammatory cytokines, due to the overactivation of complement and cytokines. The present study noted that ethyl pyruvate alleviated ALI in lipopolysaccharide (LPS)-induced ALI mice. Increased autophagy in neutrophils from ALI mice was observed, while ethyl pyruvate diminished autophagy in neutrophils and constrained granule release, and therefore myeloperoxidase (MPO) in bronchoalveolar lavage fluid and the production of proinflammatory cytokines. Using neutrophil cells, it was identified that autophagy was required for neutrophil activation and granule release, and that ethyl pyruvate caused neutrophil autophagy, leading to the restriction of granule release, and thus contributing to the mitigation of ALI. If autophagy was obviated through knockdown of key regulator of autophagy Atg5, the effects of ethyl pyruvate on granule release by neutrophils disappeared. Taken together, the results demonstrated that ethyl pyruvate alleviates ALI through inhibition of autophagy-induced granule release by neutrophils, and this mechanism suggested a novel potential therapeutic target in autophagy regulation for ALI. PMID:28098908

  13. Tailored plasma sprayed MCrAlY coatings for aircraft gas turbine applications

    NASA Technical Reports Server (NTRS)

    Pennisi, F. J.; Gupta, D. K.

    1981-01-01

    Eighteen plasma sprayed coating systems, nine based on the NiCoCrAly chemistry and nine based on the CoCrAly composition, were evaluated to identify coating systems which provide equivalent or superior life to that shown by the electron beam physical vapor deposited NiCoCrAly and CoCrAly coatings respectively. NiCoCrAly type coatings were examined on a single crystal alloy and the CoCrAly based coatings were optimized on the B1900+ Hf alloy. Cyclic burner rig oxidation and hot corrosion and tensile ductility tests used to evaluate the various coating candidates. For the single crystal alloy, a low pressure chamber plasma sprayed NiCoCrAly + Si coating exhibited a 2x oxidation life improvement at 1394 K (2050 F) over the vapor deposited NiCoCrAly material while showing equivalent tensile ductility. A silicon modified low pressure chamber plasma sprayed CoCrAly coating was found to be more durable than the baseline vapor deposited CoCrAly coating on the B1900+ Hf alloy.

  14. Neurological outcome after experimental lung injury.

    PubMed

    Bickenbach, Johannes; Biener, Ingeborg; Czaplik, Michael; Nolte, Kay; Dembinski, Rolf; Marx, Gernot; Rossaint, Rolf; Fries, Michael

    2011-12-15

    We examined the influences of acute lung injury and hypoxia on neurological outcome. Functional performance was assessed using a neurocognitive test and a neurologic deficit score (NDS) five days before. On experimental day, mechanically ventilated pigs were randomized to hypoxia only (HO group, n=5) or to acute lung injury (ALI group, n=5). Hemodynamics, respiratory mechanics, systemic cytokines and further physiologic variables were obtained at baseline, at the time of ALI, 2, 4 and 8h thereafter. Subsequently, injured lungs were recruited and animals weaned from the ventilator. Neurocognitive testing was re-examined for five days. Then, brains were harvested for neurohistopathology. After the experiment, neurocognitive performance was significantly worsened and the NDS increased in the ALI group. Histopathology revealed no significant differences. Oxygenation was comparable between groups although significantly higher inspiratory pressures occured after ALI. Cytokines showed a trend towards higher levels after ALI. Neurocognitive compromise after ALI seems due to a more pronounced inflammatory response and complex mechanical ventilation.

  15. Scalar discrete nonlinear multipoint boundary value problems

    NASA Astrophysics Data System (ADS)

    Rodriguez, Jesus; Taylor, Padraic

    2007-06-01

    In this paper we provide sufficient conditions for the existence of solutions to scalar discrete nonlinear multipoint boundary value problems. By allowing more general boundary conditions and by imposing less restrictions on the nonlinearities, we obtain results that extend previous work in the area of discrete boundary value problems [Debra L. Etheridge, Jesus Rodriguez, Periodic solutions of nonlinear discrete-time systems, Appl. Anal. 62 (1996) 119-137; Debra L. Etheridge, Jesus Rodriguez, Scalar discrete nonlinear two-point boundary value problems, J. Difference Equ. Appl. 4 (1998) 127-144].

  16. Development of a PTSD Population Registry

    DTIC Science & Technology

    2009-09-01

    OUTCOMES   Keane, T.M., Rosen, R., Maserejian, N., Holowka, D.W., Rodriguez, P., Marx, B.P., Kang,  H., Vasterling, J.J. Wunderle, K.B.,  Rodier , N.A...Holowka, D.W., Rodriguez, P., Marx, B.P., Kang,  H., Vasterling, J.J. Wunderle, K.B.,  Rodier , N.A., Sloan D.S.,  Friedman, M.J., Sleeper, L.A.  (2009

  17. Development of a PTSD Population Registry

    DTIC Science & Technology

    2010-09-01

    Keane, T.M., Rosen, R., Maserejian, N., Holowka, D.W., Rodriguez, P., Marx, B.P., Kang, H., Vasterling, J.J. Wunderle, K.B., Rodier , N.A., Sloan D.S...Rodriguez, P., Marx, B.P., Kang, H., Vasterling, J.J. Wunderle, K.B., Rodier , N.A., Sloan D.S., Friedman, M.J., Sleeper, L.A. (2009). Creation of a PTSD...City, MO. Rosen, R.C., Keane, T.M., Marx, B.P., Maserejian, N.N., Holowka, D.W., Kang, H.K., Vasterling, J.J., Rodier , N.A., Sleeper, L.A. (2010

  18. Role of NuSAP in Prostate Tumor Progression

    DTIC Science & Technology

    2012-06-01

    RNA extraction. DNA, RNA and microRNA were isolated from each tissue sample using Qiagen AllPrep DNA/RNA mini kit (Qiagen Inc., Valencia , CA, USA...prostate cancer. Nature 2002; 419: 624 - 629. 11 Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang- Rodriguez J, Moskaluk CA et al. Analysis of gene...cancer: which definition(s) to use? Breast Cancer Res 2011; 13: 105. 41 Rodriguez -Enriquez S, Pacheco-Velazquez SC, Gallardo-Perez JC, Marin-Hernandez A

  19. Role of Diet Modulation and AMPK in Ovaria Cancer Progression and Outcome

    DTIC Science & Technology

    2012-10-01

    planted with ovarian tumors as before and treated with metformin ( 100mg/kg body weight) and berberine (5mg/kg body weight) by oral administration and...Cancer statistics, 2007. CA Cancer J Clin 2007;57: 43-66. http://www.ncbi.nlm.nih.gov/ pubmed /17237035 2. Bandera EV, Kushi LH, Rodriguez-Rodriguez L...Nutritional factors in ovarian cancer survival. Nutr Cancer 2009;61: 580-6. http://www.ncbi.nlm.nih.gov/ pubmed /19838931 3. Kolahdooz F, Ibiebele

  20. Studies of Prostate Tumor Development via Cre/LoxP Technology

    DTIC Science & Technology

    2003-05-01

    used routinely in our transgenic experiments (Robles et al., 1996; Rodriguez Puebla et al., 2000). Crosses with Rosa 26 mice have already been...enzyme substrate for beta-galactosidase. Biol Chem Hoppe Seyler, 373(12):1187-91, Dec. 1992. Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ...Sci, 93:7634-7638, 1996. Rodriguez- Puebla , M.L., LaCava, M., Miliani de Marval, P.L., Jorcano, J.L., Richie, E.R. and Conti, C.J. Cyclin D2

  1. Evaluation of Uncertainty in Constituent Input Parameters for Modeling the Fate of IMX 101 Components

    DTIC Science & Technology

    2017-05-01

    Pesce-Rodriguez, M. Brusseau, J. Arthur, N. Mark, M. Walsh, J. Lever , J. Šimůnek. 2014a. Dissolution of NTO, DNAN, and insensitive munitions...Arthur, N. Mark, S. Taylor, J. Lever , M. Walsh, R. Pesce- Rodriguez, and J. Šimůnek. 2014b. Dissolution of NTO, DNAN, and insensitive munitions... Lever , J. Pitt, J. Bradley, M. Walsh, and J. Šimůnek. 2012. Dissolution rate of propellant energetics from nitrocellulose matrices. ERDC/CRREL TR-12-9

  2. Effects of different tidal volumes in pulmonary and extrapulmonary lung injury with or without intraabdominal hypertension.

    PubMed

    Santos, Cíntia L; Moraes, Lillian; Santos, Raquel S; Oliveira, Mariana G; Silva, Johnatas D; Maron-Gutierrez, Tatiana; Ornellas, Débora S; Morales, Marcelo M; Capelozzi, Vera L; Jamel, Nelson; Pelosi, Paolo; Rocco, Patricia R M; Garcia, Cristiane S N B

    2012-03-01

    We hypothesized that: (1) intraabdominal hypertension increases pulmonary inflammatory and fibrogenic responses in acute lung injury (ALI); (2) in the presence of intraabdominal hypertension, higher tidal volume reduces lung damage in extrapulmonary ALI, but not in pulmonary ALI. Wistar rats were randomly allocated to receive Escherichia coli lipopolysaccharide intratracheally (pulmonary ALI) or intraperitoneally (extrapulmonary ALI). After 24 h, animals were randomized into subgroups without or with intraabdominal hypertension (15 mmHg) and ventilated with positive end expiratory pressure = 5 cmH(2)O and tidal volume of 6 or 10 ml/kg during 1 h. Lung and chest wall mechanics, arterial blood gases, lung and distal organ histology, and interleukin (IL)-1β, IL-6, caspase-3 and type III procollagen (PCIII) mRNA expressions in lung tissue were analyzed. With intraabdominal hypertension, (1) chest-wall static elastance increased, and PCIII, IL-1β, IL-6, and caspase-3 expressions were more pronounced than in animals with normal intraabdominal pressure in both ALI groups; (2) in extrapulmonary ALI, higher tidal volume was associated with decreased atelectasis, and lower IL-6 and caspase-3 expressions; (3) in pulmonary ALI, higher tidal volume led to higher IL-6 expression; and (4) in pulmonary ALI, liver, kidney, and villi cell apoptosis was increased, but not affected by tidal volume. Intraabdominal hypertension increased inflammation and fibrogenesis in the lung independent of ALI etiology. In extrapulmonary ALI associated with intraabdominal hypertension, higher tidal volume improved lung morphometry with lower inflammation in lung tissue. Conversely, in pulmonary ALI associated with intraabdominal hypertension, higher tidal volume increased IL-6 expression.

  3. Minimum Nuclear Deterrence Postures in South Asia: An Overview

    DTIC Science & Technology

    2001-10-01

    the context of the publication in India of the "NSAB Draft Report ... on Indian Nuclear Doctrine," is Agha Shahi, Zulfiqar Ali Khan and Abdul Sattar...Minister of Pakistan, and Air Marshall Zulfiqar Ali Khan formerly was Pakistan’s Air Force Commander in Chief. 50 President Pervez Musharraf’s Oct. 19...pp. 67-87. Shahi, Agha, Air Marshall (retd.) Zulfiqar Ali Khan and Abdul Sattar, "Securing Nuclear Peace," The News International, October 5, 1999

  4. Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase from Pseudoalteromonas sp. SM0524

    PubMed Central

    Chen, Xiu-Lan; Dong, Sheng; Xu, Fei; Dong, Fang; Li, Ping-Yi; Zhang, Xi-Ying; Zhou, Bai-Cheng; Zhang, Yu-Zhong; Xie, Bin-Bin

    2016-01-01

    Marine bacterial alginate lyases play a role in marine alginate degradation and carbon cycling. Although a large number of alginate lyases have been characterized, reports on alginate lyases with special characteristics are still rather less. Here, a gene alyPM encoding an alginate lyase of polysaccharide lyase family 7 (PL7) was cloned from marine Pseudoalteromonas sp. SM0524 and expressed in Escherichia coli. AlyPM shows 41% sequence identity to characterized alginate lyases, indicating that AlyPM is a new PL7 enzyme. The optimal pH for AlyPM activity was 8.5. AlyPM showed the highest activity at 30°C and remained 19% of the highest activity at 5°C. AlyPM was unstable at temperatures above 30°C and had a low Tm of 37°C. These data indicate that AlyPM is a cold-adapted enzyme. Moreover, AlyPM is a salt-activated enzyme. AlyPM activity in 0.5–1.2 M NaCl was sixfolds higher than that in 0 M NaCl, probably caused by a significant increase in substrate affinity, because the Km of AlyPM in 0.5 M NaCl decreased more than 20-folds than that in 0 M NaCl. AlyPM preferably degraded polymannuronate and mainly released dimers and trimers. These data indicate that AlyPM is a new PL7 endo-alginate lyase with special characteristics. PMID:27486451

  5. Pakistan’s Nuclear Weapons: Proliferation and Security Issues

    DTIC Science & Technology

    2012-06-26

    Sheet, http://www.armscontrol.org/factsheets/missiles.asp; and Mahmud Ali Durrani, “Pakistan’s Strategic Thinking and the Role of Nuclear Weapons...continued) Pakistan, November 22, 2008; “Interview with President Asif Ali Zardari,” CNN Larry King Live, December 2, 2008...President Musharraf stated in November 2007 that Pakistan’s nuclear weapons are under “total custodial controls.”124 More recently, President Asif Ali

  6. Islamic Fundamentalism in Pakistan. Its Characters and Prospects

    DTIC Science & Technology

    1991-01-01

    For although Pakistan was founded as a Muslim homeland, it was not at all the intention of its founder, Muhammad Ali Jinnah , that the state should be...origin: "* The founder of Pakistan, Muhammad ’ Ali Jinnah , was of Isma’ili background; "* Yahya Khan, former Commander in Chief of the Army, and then...more interested in socialist policies or regional issues. Islam entered more fully into the political debate when former Prime Minister Zulfikar Ali

  7. JPRS Report, Near East & South Asia: Pakistan

    DTIC Science & Technology

    1993-06-15

    to "hear no evil", "see no evil" and "speak no Factories boss Maj. Gen. Mahmood Ali Durrani, an evil" are secretly decided in advance by mutual...nuclear technology, especially to the Middle East..." [Text] Whether the recent meeting between Pakistan’s Federal Minister, Chaudhry Nisar Ali , who...Nisar Ali , On his part, gave Mr Warren Christopher every obtain Russian cyrogenic [as published] rocket engines assurance that Pakistan was opposed

  8. Angiopoietin balance in septic shock patients with acute lung injury: effect of direct hemoperfusion with polymyxin B-immobilized fiber.

    PubMed

    Ebihara, Itaru; Hirayama, Kouichi; Nagai, Miho; Kakita, Tomoko; Sakai, Kentaro; Tajima, Reiko; Sato, Chihiro; Kurosawa, Hiromi; Togashi, Amane; Okada, Akiko; Usui, Joichi; Yamagata, Kunihiro; Kobayashi, Masaki

    2011-08-01

    Acute lung injury (ALI) in sepsis is characterized by an increase in microvascular permeability, resulting in pulmonary edema. Several studies have suggested that angiopoietin-1 and -2 play a contributory role in the pathogenesis of ALI. Polymyxin B-immobilized fiber column hemoperfusion is effective for sepsis-induced ALI. We investigated the angiopoietin levels before and after direct hemoperfusion with polymyxin B-immobilized fiber column (PMX) therapy. Enzyme-linked immunoassay was used to measure the serum angiopoietin-1 and -2 levels in 25 patients with septic shock treated with PMX. Eleven of the 25 patients were diagnosed with ALI. There was a significant positive correlation between the angiopoietin-1 level and the PaO(2) /FiO(2) ratio, but there was a significant inverse correlation between the angiopoietin-2 level and the PaO(2) /FiO(2) ratio. The mean angiopoietin-1 level before PMX therapy in the ALI group was significantly lower and the mean angiopoietin-2 level was significantly higher than in the non-ALI group. The mean angiopoietin-1 level of the ALI patients in response to PMX therapy was increased during PMX therapy, but that of the non-ALI patients with newly occurring ALI showed a decreased angiopoietin-1 level. On the other hand, the mean angiopoietin-2 level of the responders was decreased during PMX therapy, but that of patients with newly occurring ALI showed an increased angiopoietin-2 level. This result suggested that each angiopoietin-1 and -2 level may play a role in the pathogenesis of ALI and that PMX therapy ameliorates the angiopoietin balance in patients with ALI in sepsis. © 2011 The Authors. Therapeutic Apheresis and Dialysis © 2011 International Society for Apheresis.

  9. Developing an Evaluation Method for Middleware-Based Software Architectures of Airborne Mission Systems

    DTIC Science & Technology

    2007-07-01

    documented using an architecture knowledge management tool also developed at NICTA. 31 DSTO-TR-2204 9. References [Ali- Babar & Gorton 2004] [Ali... Babar et al. 2005] [Allen et al. 2002] [Bachmann et al. 2003] [Barbacci et al. 1995] [Bass et al. 2003] [Basse/al. 2001] [Bengstsson et al. 2004...Boehm&In 1996] [CORBA 2006] [Clements et al. 2001] Ali- Babar , M. & Gorton, I. (2004) Comparison of Scenario-Based Software Architecture

  10. 76 FR 42024 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    .../A319/A320/A321 ALI Document reference AI/SE-M4/95A.0252/ 96 and Airbus A319 Corporate Jet ALI Document reference AI/SE-M2/ 95A.1038/99, which are approved by the European Aviation Safety Agency (EASA) and... specified in Airbus A318/A319/A320/A321 ALI Document reference AI/ SE-M4/95A.0252/96 issue 10 and...

  11. 75 FR 52246 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... (Airworthiness Limitations Section) part 2 under ALI Document reference AI/SE-M4/95A.0252/96 at issue 7; approved... A318/A319/A320/A321 Airworthiness Limitation Items (ALI) AI/SE-M4/95A.0252/96, Issue 09, dated November... 552007-01-1 or 552007-01-3, which is defined in Airbus A318/A319/A320/A321 ALI AI/...

  12. 76 FR 4260 - Airworthiness Directives; Airbus Model A300 and A310 Series Airplanes, and Model A300 B4-600, B4...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Service Information Airbus has issued A300-600 Airworthiness Limitation Items (ALI) Document AI/SE-M2/95A.1310/07, Issue 12, dated June 2008; A300 ALI Document AI/SE-M2/95A.1308/07, Issue 4, dated June 2008; and A310 ALI Document, AI/SE-M2/95A.1309/07, Issue 7, dated June 2008. The actions described in...

  13. 76 FR 16582 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... A318/A319/A320/ A321 Airworthiness Limitation Items, Document AI/SE-M4/95A.0252/96, Issue 7, dated... ALI Document reference AI/SE-M4/95A.0252/ 96 and Airbus A319 Corporate Jet ALI Document reference AI... specified in Airbus A318/A319/A320/A321 ALI Document reference AI/ SE-M4/95A.0252/96 issue 10 and...

  14. Infection site is predictive of outcome in acute lung injury associated with severe sepsis and septic shock.

    PubMed

    Fujishima, Seitaro; Gando, Satoshi; Daizoh, Saitoh; Kushimoto, Shigeki; Ogura, Hiroshi; Mayumi, Toshihiko; Takuma, Kiyotsugu; Kotani, Joji; Yamashita, Norio; Tsuruta, Ryosuke; Takeyama, Naoshi; Shiraishi, Shin-Ichiro; Araki, Tsunetoshi; Suzuki, Koichiro; Ikeda, Hiroto; Miki, Yasuo; Suzuki, Yasushi; Yamaguchi, Yoshihiro; Aikawa, Naoki

    2016-07-01

    Sepsis is a leading cause of acute lung injury (ALI); however, the characteristics and outcome of sepsis-associated ALI are poorly understood. We aimed to elucidate factors that predict patient outcome in sepsis-associated ALI. Secondary analysis of a multicenter, prospective, observational study was performed. Among 624 patients with severe sepsis and septic shock, 251 (40.2%) fulfilled the definition of American-European Consensus Conference definition of ALI. All-cause 28-day and in-hospital mortalities were 30.7% and 38.6%, respectively. More than 40% of ALI patients had neurological, cardiovascular and haematological dysfunctions or disseminated intravascular coagulation, all of which were associated with higher mortality. We report a significant correlation between infection site and mortality in patients with ALI, but not in those without ALI. The proportion of ALI was significantly higher in pulmonary sepsis; further, a complication of ALI was associated with higher mortality in sepsis from pulmonary and other sources, but not in abdominal sepsis. Among the other sepsis sites, urinary tract, central nervous system, catheter-related and undetermined foci of infection had worse outcomes when associated with ALI. None of the individual severe sepsis bundles, including fluid resuscitation and early antibiotic administration, correlated with mortality. Compliance with a set of sepsis management bundles was associated with better outcomes. In severe sepsis and septic shock, the proportion and effect on outcome was not uniform among infection sites. The infection site was predictive of outcome in patients with ALI but not in those without ALI. © 2016 Asian Pacific Society of Respirology.

  15. tombola, a tesmin/TSO1 family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with Always early

    PubMed Central

    Jiang, Jianqiao; Benson, Elizabeth; Bausek, Nina; Doggett, Karen; White-Cooper, Helen

    2008-01-01

    Summary During male gametogenesis a developmentally regulated and cell type specific transcriptional programme is activated in primary spermatocytes to prepare for differentiation of sperm. The Drosophila aly-class meiotic arrest loci (aly, comr, achi/vis and topi) are essential for activation of transcription of many differentiation-specific genes, and several genes important for meiotic cell cycle progression, thus linking meiotic divisions to cellular differentiation during spermatogenesis. Protein interaction studies suggests that the aly-class gene products form a chromatin-associated complex in primary spermatocytes. We identify, clone and characterise a new aly-class meiotic arrest gene, tombola (tomb), which encodes a testis-specific CXC domain protein that interacts with Aly. The tomb mutant phenotype is more like aly and comr than like achi/vis or topi in terms of target gene profile and chromosome morphology. tomb encodes a chromatin-associated protein required for localisation of Aly and Comr, but not Topi, to chromatin Reciprocally, aly and comr, but not topi or achi/vis, are required to maintain the normal localisation of Tomb. tomb and aly may be components of a complex paralogous to the Drosophila dREAM/MybMuv-B and C. elegans DRM transcriptional regulatory complexes. PMID:17360778

  16. Anti-Libidinal Interventions in Sex Offenders: Medical or Correctional?

    PubMed Central

    Douglas, Thomas

    2016-01-01

    Abstract Sex offenders are sometimes offered or required to undergo pharmacological interventions intended to diminish their sex drive (anti-libidinal interventions or ALIs). In this paper, we argue that much of the debate regarding the moral permissibility of ALIs has been founded on an inaccurate assumption regarding their intended purpose—namely, that ALIs are intended solely to realise medical purposes, not correctional goals. This assumption has made it plausible to assert that ALIs may only permissibly be administered to offenders with their valid consent, in line with the approach taken to most other interventions with a medical aim. However, we argue that, contrary to this assumption, the state's intention in relation to at least some ALIs is, at least in part, to achieve correctional objectives. We evaluate two legal regimes for ALI provision—section 645 of the California Penal Code and the mental health regime in England and Wales. In each case, we identify the state's implicit purpose in imposing ALIs and argue that the Californian and English regimes both serve as counterexamples to the view that ALIs are intended solely for medical purposes. While the moral implications of our argument are not straightforward, it raises the question whether consent is required for permissible imposition of ALIs, and more generally, whether the moral permissibility of crime-preventing interventions using medical means should be assessed against the standards of medical ethics or against those of criminal justice ethics. PMID:28158492

  17. Recurrent Arterial Thrombosis as a Presenting Feature of a Variant M3-Acute Promyelocytic Leukemia

    PubMed Central

    Chotai, Pranit N.; Kasangana, Kalenda; Chandra, Abhinav B.; Rao, Atul S.

    2016-01-01

    Acute limb ischemia (ALI) is a common vascular emergency. Hematologic malignancies are commonly associated with derangement of normal hemostasis and thrombo-hemorrhagic symptoms during the course of the disease are common. However, ALI as an initial presenting feature of acute leukemia is rare. Due to the rarity of this presentation, there is a scarcity of prospective randomized data to optimally guide the management of these patients. Current knowledge is mainly based on isolated cases. We report our experience managing a patient who presented with ALI and was found to have occult leukemia. A review of all cases with ALI as a presenting feature of acute leukemia is also presented. PMID:27386455

  18. Isoflurane Prevents Acute Lung Injury Through ADP-Mediated Platelet Inhibition

    PubMed Central

    Harr, Jeffrey N.; Moore, Ernest E.; Stringham, John; Wohlauer, Max V.; Fragoso, Miguel; Jones, Wilbert L.; Gamboni, Fabia; Silliman, Christopher C.; Banerjee, Anirban

    2012-01-01

    Background Growing evidence suggests platelets are essential in post-traumatic acute lung injury (ALI). Halogenated ethers interfere with platelet-granulocyte aggregate formation. The potential benefit of halogenated ethers has not been investigated in trauma/hemorrhagic shock (T/HS) models. Therefore, we hypothesized that isoflurane decreases T/HS-mediated ALI through platelet inhibition. Methods Sprauge-Dawley rats (n=47) were anesthetized by either pentobarbital or inhaled isoflurane, and placed into groups: control, trauma (laparotomy) sham shock, T/HS (MAP of 30 mmHg × 45 min), pre-treatment with an ADP receptor antagonist, or T/HS with isoflurane initiated during resuscitation. ALI was determined by BALF protein and pulmonary immunofluorescence. PlateletMapping™ specifically evaluated thrombin-independent inhibition of the ADP and AA pathways of platelet activation. Results Pre-treatment with isoflurane abrogated ALI as measured by both BAL fluid protein and pulmonary immunofluorescence (p<0.001). PlateletMapping™, revealed specific platelet ADP-pathway inhibition with isoflurane (p<0.001). Pre-treatment with an ADP receptor antagonist decreased ALI to sham levels, confirming that specific platelet ADP inhibition decreases ALI. Isoflurane initiated during resuscitation also decreased ALI (p<0.001). Conclusion Isoflurane attenuates ALI through an anti-platelet mechanism, in part, through inhibition of the platelet ADP pathway. Isoflurane given post-injury also protects against ALI, and highlights the potential applications of this therapy in various ischemia/reperfusion clinical scenarios. PMID:22828148

  19. Site characterization studies in high plateau of Tibet

    NASA Astrophysics Data System (ADS)

    Yao, Yongqiang; Wang, Hongshuai; Liu, Liyong; Wang, Yiping; Qian, Xuan; Yin, Jia

    2012-09-01

    The site survey in western China has been carried out since 2003. Remote studies and local surveys are performed, and Oma site, Ali area in southwest Tibet, has been selected in 2005 to make site testing measurements. The monitoring results show that Ali area can be the best choice for astronomical observations over the East Asian regions. A new site in Ali has been identified and begun construction in 2010 for small telescopes and detailed site characterization. This paper reviews the long term site survey, presents site characteristics in Tibet, and introduces current status of the new Ali observatory.

  20. Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial

    PubMed Central

    Varelmann, Dirk; Muders, Thomas; Zinserling, Jörg; Guenther, Ulf; Magnusson, Anders; Hedenstierna, Göran; Putensen, Christian; Wrigge, Hermann

    2008-01-01

    Introduction Acute lung injury (ALI) can result from various insults to the pulmonary tissue. Experimental and clinical data suggest that spontaneous breathing (SB) during pressure-controlled ventilation (PCV) in ALI results in better lung aeration and improved oxygenation. Our objective was to evaluate whether the addition of SB has different effects in two different models of ALI. Methods Forty-four pigs were randomly assigned to ALI resulting either from hydrochloric acid aspiration (HCl-ALI) or from increased intra-abdominal pressure plus intravenous oleic acid injections (OA-ALI) and were ventilated in PCV mode either with SB (PCV + SB) or without SB (PCV – SB). Cardiorespiratory variables were measured at baseline after induction of ALI and after 4 hours of treatment (PCV + SB or PCV – SB). Finally, density distributions and end-expiratory lung volume (EELV) were assessed by thoracic spiral computed tomography. Results PCV + SB improved arterial partial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) by a reduction in intrapulmonary shunt fraction in HCl-ALI from 27% ± 6% to 23% ± 13% and in OA-ALI from 33% ± 19% to 26% ± 18%, whereas during PCV – SB PaO2/FiO2 deteriorated and shunt fraction increased in the HCl group from 28% ± 8% to 37% ± 17% and in the OA group from 32% ± 12% to 47% ± 17% (P < 0.05 for interaction time and treatment, but not ALI type). PCV + SB also resulted in higher EELV (HCl-ALI: 606 ± 171 mL, OA-ALI: 439 ± 90 mL) as compared with PCV – SB (HCl-ALI: 372 ± 130 mL, OA-ALI: 192 ± 51 mL, with P < 0.05 for interaction of time, treatment, and ALI type). Conclusions SB improves oxygenation, reduces shunt fraction, and increases EELV in both models of ALI. PMID:18980696