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Sample records for rodriguez moonis ali

  1. Rodriguez: The State Courts Respond.

    ERIC Educational Resources Information Center

    Long, David C.

    1983-01-01

    Summarizes 16 state court decisions in 15 states concerning equity in statewide school finance systems, in the aftermath of the Supreme Court's San Antonio Independent School District v. Rodriguez" decision. Finds that some state legislatures and courts reformed their finance systems, while others let inequalities continue. (RW)

  2. School Finance a Decade after Rodriguez.

    ERIC Educational Resources Information Center

    Flygare, Thomas J.

    1983-01-01

    Discusses the U.S. Supreme Court's decision in "San Antonio Independent School District v. Rodriguez," handed down 10 years ago, concerning financial equity in the Texas school finance program. Summarizes Justice Powell's majority opinion and Justice Marshall's dissent and introduces the two following articles assessing the decision's…

  3. ALIS deployment in Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Takahashi, Kazunori

    2012-06-01

    Dual sensor is one of the most promising sensors for humanitarian demining operations. Conventional landmine detection depends on highly trained and focused human operators manually sweeping 1m2 plots with a metal detector and listening for characteristic audio signals indicating the presence of AP (Anti-personnel) landmines. In order to reduce the time of plodding detected objects, metal detectors need to be combined with a complimentary subsurface imaging sensor. i.e., GPR(Ground Penetrating Radar). The demining application requires real-time imaging results with centimetre resolution in a highly portable package. We are currently testing a dual sensor ALIS which is a real-time sensor tracking system based on a CCD camera and image processing. In this paper we introduce ALIS systems which we have developed for detection of buried antipersonnel mines and small size explosives. The performance of ALIS has been tested in Cambodia since 2009. More than 80 anti-personnel mines have been detected and removed from local agricultural area. ALIS has cleared more than 70,000 m2 area and returned it to local farmers.

  4. ALIS evaluation tests in Croatia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Fujiwara, Jun; Kido, Takashi; Takahashi, Kazunori

    2009-05-01

    Tohoku University, Japan is developing a new hand-held land mine detection dual-sensor (ALIS) which is equipped with a metal detector and a GPR. ALIS is equipped with a sensor tracking system, which can record the GPR and Metal detector signal with its location. The Migration processing drastically increases the quality of the imaging of the buried objects.Evaluation test of ALIS has been conducted several test sites. Tests in real mine fields in Croatia has been conducted between December 2007 and April 2008. Under different soil and environment conditions, ALIS worked well. Then ALIS evaluation test started in Cambodia in February 2009 and we could find discrimination capability of ALIS in test lanes, and we are planning to start evaluation test in real mine fields in Cambodia.

  5. Descubriendo La Lectura: An Interview with Yvonne Rodriguez.

    ERIC Educational Resources Information Center

    Rodriguez, Yvonne; Askew, Billie; Frasier, Dianne

    1997-01-01

    Through an interview with educator Yvonne Rodriguez, this article discusses Descubriendo La Lectura (DLL), the result of educators' efforts in the Collaborative for Reading Recovery in Spanish. It discusses background information about DLL, how it may be implemented, requirements for and means of teacher leader training, and the requirements for…

  6. Whose Voice Is It Anyway? Rodriguez' Speech in Retrospect.

    ERIC Educational Resources Information Center

    Villanueva, Victor Jr.

    1987-01-01

    Questions Richard Rodriguez' position that linguistic assimilation for minorities is like alchemy, creating something new and greater than what was. Concludes that it is better for teachers to teach students to use the conventions of standard discourse without accepting the ideology of those for whom the standard dialect is the language of…

  7. A Decade after Rodriguez: An Interview with John Coons.

    ERIC Educational Resources Information Center

    Phi Delta Kappan, 1983

    1983-01-01

    John Coons, coauthor of a book on equity in public education finance that influenced the theories tested in "San Antonio Independent School District v. Rodriguez," discusses the issues involved in the case, the likely impact had the decision favored the plaintiffs, and the future of school finance reform. (RW)

  8. Equity in State Education Finance: A Response to "Rodriguez."

    ERIC Educational Resources Information Center

    Verstegen, Deborah A.

    1987-01-01

    A decade after "San Antonio v Rodriguez" (1973), a historic ruling on the unjust Texas educational finance system, the state's Education Opportunity Act (1984) finally replaced existing statutory formulas with a weighted pupil average system and committed $2.8 billion to education over the next three years. A statistical analysis shows…

  9. Chasing Personal Meaning: Pedagogical Lessons through Luis Rodriguez's "Always Running"

    ERIC Educational Resources Information Center

    Theisen-Homer, Victoria

    2014-01-01

    In this autobiographical narrative, the author recounts her experiences teaching the novel "Always Running" by Luis Rodriguez with her English classes at a high school in a gang-heavy area. When she first started teaching, this teacher struggled to engage students. One particularly disruptive student requested to read "Always…

  10. Brains versus Brawn: Classed and Racialized Masculinity in Literacy Narratives by Rose, Rodriguez, Villanueva, and Gilyard

    ERIC Educational Resources Information Center

    Launius, Christie

    2009-01-01

    A feminist reading of four prominent literacy narratives--Mike Rose's "Lives on the Boundary," Richard Rodriguez's "Hunger of Memory," Victor Villanueva's "Bootstraps," and Keith Gilyard's "Voices of the Self"--shows that conflicts and anxieties about the consequences of schooling on working-class masculinity animate these texts. Each of these…

  11. The Role of Federal Aid in the Post-Rodriguez Period

    ERIC Educational Resources Information Center

    Burke, Joel S.

    1973-01-01

    Whether the U.S. Supreme Court reverses the Rodriguez v. San Antonio Independent School District (1971)'' decision or upholds it, ordering that state school finance systems not make expenditures a function of local wealth, federal aid can play an important role. (JM)

  12. The Enduring Legacy of "Rodriguez": Creating New Pathways to Equal Educational Opportunity

    ERIC Educational Resources Information Center

    Ogletree, Charles J., Jr., Ed.; Robinson, Kimberly Jenkins, Ed.

    2015-01-01

    In this ambitious volume, leading legal and educational scholars examine "San Antonio Independent School District v. Rodriguez" (1973), the landmark US Supreme Court decision that held that the Constitution does not guarantee equality of educational opportunity. Charles J. Ogletree, Jr., and Kimberly Jenkins Robinson have brought…

  13. Revisiting "Rodriguez v. Los Angeles Unified School District": A Case of Intra-District Inequities

    ERIC Educational Resources Information Center

    Espinosa, Ruben W.

    2010-01-01

    The educational community and the courts continue to struggle with the challenges of intra-district resource inequality revealed by the California Supreme Court landmark case "Rodriguez v. Los Angeles Unified School District" (1992). Intra-district school resource inequality is one of the remaining bastions of major inequalities in the…

  14. Tomographic inversion for ALIS noise and resolution

    NASA Astrophysics Data System (ADS)

    Gustavsson, Björn

    1998-11-01

    In this report the problems of resolution and noise sensitivity of tomographic reconstructions from ground-based multistation imaging of aurora with the auroral large imaging system (ALIS) are considered. ALIS is a ground-based grid of high-performance CCD-imaging stations at high latitudes. For evaluation of the resolution and noise sensitivity of current tomographic reconstruction procedures a full model simulation of the ALIS system is presented. The results show that relative errors are typically in the range 0.05-0.1 for typical noise levels in measurements of aurora. A general method to estimate resolution in a tomographic imaging system is developed and used to give estimates of the horizontal and vertical resolution. Its current limitations and future perspective are briefly discussed. A method to retrieve feasible tomographic reconstructions from a few image projections with variable noise level are outlined.

  15. Atmospheric monitoring strategy for the Ali site, Tibet

    NASA Astrophysics Data System (ADS)

    Yao, Y.; Zhou, Y.; Liu, L.; Wang, H.; Yin, J.; You, X.; Fu, X.

    2015-04-01

    The astronomical site survey in China has been carried out since 2003. Remote studies and local surveys are performed over the high plateaus, and candidate sites have been selected and performed site testing measurements. The monitoring results show that Ali area in western Tibet can be the best choice for astronomical observations over East Asian regions. Ali site, near the central town of Ali area, has been further identified for small telescope projects and simultaneously for detailed site characterization, and begun construction in 2010. This paper presents the site monitoring strategy and site development plan of the new Ali observatory.

  16. The Hall-Rodriguez theory of latent inhibition: Further assessment of compound stimulus preexposure effects.

    PubMed

    Rodríguez, Gabriel; Márquez, Raúl; Gil, Marta; Alonso, Gumersinda; Hall, Geoffrey

    2014-10-01

    According to a recent theory (Hall & Rodriguez, 2010), the latent inhibition produced by nonreinforced exposure to a target stimulus (B) will be deepened by subsequent exposure of that stimulus in compound with another (AB). This effect of compound exposure is taken to depend on the addition of a novel A to the familiar B and is not predicted for equivalent preexposure on which AB trials precede the A trials. This prediction was tested in 2 experiments using rats. Experiment 1 used an aversive procedure with flavors as the stimuli; Experiment 2 used an appetitive procedure with visual and auditory stimuli. In both, we found that conditioning with B as the conditioned stimulus proceeded more slowly (i.e., latent inhibition was greater) in subjects given the B-AB sequence in preexposure than in subjects given the AB-B sequence.

  17. VizieR Online Data Catalog: ubvyHβ photometry of AB Cas (Rodriguez+ 1998)

    NASA Astrophysics Data System (ADS)

    Rodriguez, E.; Claret, A.; Sedano, J. L.; Garcia, J. M.; Garrido, R.

    1998-09-01

    Table 1 contents 471 simultaneous measurements collected in each of the four uvby colours of the Stroemgren photometric system for the eclipsing binary system AB Cas. Because of an instrumental problem, 82 points in the b channel (during the last observational night) had to be rejected (the corresponding magnitudes are listed as 0.0000). The data are magnitude differences (Du,Dv,Db,Dy) of the variable star minus comparison star in the instrumental system versus Heliocentric Julian Day. Table 2 is the same, but for Hβ (80 points). The comparison star is BD+70 0188. The origin in time is the Julian Day 2447117. The observations were carried out (by E. Rodriguez, A. Claret, J.L. Sedano, J.M. Garcia and R. Garrido) during 1987 and 1988 using the 0.90m telescope at the Sierra Nevada Observatory, Spain. (2 data files).

  18. A further assessment of the Hall-Rodriguez theory of latent inhibition.

    PubMed

    Leung, Hiu Tin; Killcross, A S; Westbrook, R Frederick

    2013-04-01

    The Hall-Rodriguez (G. Hall & G. Rodriguez, 2010, Associative and nonassociative processes in latent inhibition: An elaboration of the Pearce-Hall model, in R. E. Lubow & I. Weiner, Eds., Latent inhibition: Data, theories, and applications to schizophrenia, pp. 114-136, Cambridge, England: Cambridge University Press) theory of latent inhibition predicts that it will be deepened when a preexposed target stimulus is given additional preexposures in compound with (a) a novel stimulus or (b) another preexposed stimulus, and (c) that deepening will be greater when the compound contains a novel rather than another preexposed stimulus. A series of experiments studied these predictions using a fear conditioning procedure with rats. In each experiment, rats were preexposed to 3 stimuli, 1 (A) taken from 1 modality (visual or auditory) and the remaining 2 (X and Y) taken from another modality (auditory or visual). Then A was compounded with X, and Y was compounded with a novel stimulus (B) taken from the same modality as A. A previous series of experiments (H. T. Leung, A. S. Killcross, & R. F. Westbrook, 2011, Additional exposures to a compound of two preexposed stimuli deepen latent inhibition, Journal of Experimental Psychology: Animal Behavior Processes, Vol. 37, pp. 394-406) compared A with Y, finding that A was more latently inhibited than Y, the opposite of what was predicted. The present experiments confirmed that A was more latently inhibited than Y, showed that this was due to A entering the compound more latently inhibited than Y, and finally, that a comparison of X and Y confirmed the 3 predictions made by the theory.

  19. Modernizing "San Antonio Independent School District v. Rodriguez": How Evolving Supreme Court Jurisprudence Changes the Face of Education Finance Litigation

    ERIC Educational Resources Information Center

    Saleh, Matthew

    2011-01-01

    This article aims to "modernize" the current legal debate over inequitable public school funding at the state and local level. The 1973 Supreme Court case of "San Antonio Independent School District v. Rodriguez" established precedent, allowing for property-tax based education funding programs at the state-level--a major source…

  20. VizieR Online Data Catalog: HD 163151: a new W UMa type system (Rodriguez+ 1998)

    NASA Astrophysics Data System (ADS)

    Rodríguez, E.; Claret, A.; García, J. M.; Zerbi, F. M.; Garrido, R.; Martín, S.; Akan, C.; Luedeke, K.; Keskin, V.; Ibanoglu, C.; Evren, S.; Tunca, Z.; Pekunlu, R.; Paparo, M.; Nuspl, J.; Krisciunas, K.; Jiang, S. Y.

    1998-06-01

    Table 2 contains 408 simultaneous measurements collected in each of the four uvby colours of the Stromgren photometric system for the W UMa system HD 163151. The data are magnitude differences (Du, Dv, Db, Dy, D(b-y), Dm1, Dc1) of the variable star minus comparison star in the standard system versus Heliocentric Julian Day. Tables 3, 4 and 5 are the same, but for Hβ (65 points), Johnson B data (212 points) and Johnson V data (355 points). The comparison star is HD 166095. The origin in time is the Julian Day 2449858. The observations were carried out (by E. Rodriguez, A. Claret, J.M. Garcia, F.M. Zerbi, R. Garrido, S. Martin, C. Akan, K. Luedeke, V. Keskin, C. Ibanoglu, S. Evren, Z. Tunca, R. Pekunlu, M. Paparo, J. Nuspl, K. Krisciunas and S.Y. Jiang) in 1995 during the course of a multisite campaign. The following telescopes were used: 90cm telescope of the Sierra Nevada Observatory, Spain (uvby-Hβ photometry); 50cm telescope at the Ege University Observatory, Turkey (BV-uvby); 50cm telescope at Piszkesteto mountain station, Konkoly Observatory, Hungary (BV); 50cm telescope at the Merate Observatory, Italy (V); 30cm telescope at Albuquerque, New Mexico, USA (V) and 15cm telescope at Mauna Kea, Hawaii, USA (V). (4 data files).

  1. Evaluation test of ALIS in Cambodia for humanitarian demining

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki

    2010-04-01

    ALIS is a hand-held dual sensor developed by Tohoku University, Japan since 2002. Dual sensor is a general name of sensor for humanitarian demining, which are equipped with metal detector and GPR. ALIS is only one hand-held dual sensor, which can record the sensor position with sensor signals. Therefore, the data can be processed after data acquisition, and can increase the imaging capability. ALIS has been tested in some mine affected courtiers including Afghanistan (2004), Egypt(2005), Croatia(2006-) and Cambodia(2007-). Mine fields at each country has different conditions and soil types. Therefore testes at the real mine fields are very important. ALIS has detected more than 30 AP-Mines in evaluation test in Cambodia held in 2009.

  2. Prognostic Significance of Modified Advanced Lung Cancer Inflammation Index (ALI) in Patients with Small Cell Lung Cancer_ Comparison with Original ALI

    PubMed Central

    Kim, Young Saing; Seo, Ja-Young; Park, Inkeun; Ahn, Hee Kyung; Jeong, Yu Mi; Kim, Jeong Ho

    2016-01-01

    Background Advanced lung cancer inflammation index (ALI, body mass index [BMI] x serum albumin/neutrophil-lymphocyte ratio [NLR]) has been shown to predict overall survival (OS) in small cell lung cancer (SCLC). CT enables skeletal muscle to be quantified, whereas BMI cannot accurately reflect body composition. The purpose was to evaluate prognostic value of modified ALI (mALI) using CT-determined L3 muscle index (L3MI, muscle area at L3/height2) beyond original ALI. Methods L3MIs were calculated using the CT images of 186 consecutive patients with SCLC taken at diagnosis, and mALI was defined as L3MI x serum albumin/NLR. Using chi-squared test determined maximum cut-offs for low ALI and low mALI, the prognostic values of low ALI and low mALI were tested using Kaplan-Meier method and Cox proportional hazards analysis. Finally, deviance statistics was used to test whether the goodness of fit of the prognostic model is improved by adding mALI as an extra variable. Results Patients with low ALI (cut-off, 31.1, n = 94) had shorter OS than patients with high ALI (median, 6.8 months vs. 15.8 months; p < 0.001), and patients with low mALI (cut-off 67.7, n = 94) had shorter OS than patients with high mALI (median, 6.8 months vs. 16.5 months; p < 0.001). There was no significant difference in estimates of median survival time between low ALI and low mALI (z = 0.000, p = 1.000) and between high ALI and high mALI (z = 0.330, p = 0.740). Multivariable analysis showed that low ALI was an independent prognostic factor for shorter OS (HR, 1.67, p = 0.004), along with advanced age (HR, 1.49, p = 0.045), extensive disease (HR, 2.27, p < 0.001), supportive care only (HR, 7.86, p < 0.001), and elevated LDH (HR, 1.45, p = 0.037). Furthermore, goodness of fit of this prognostic model was not significantly increased by adding mALI as an extra variable (LR difference = 2.220, p = 0.136). Conclusion The present study confirms mALI using CT-determined L3MI has no additional prognostic

  3. Site Protection Program and Progress Report of Ali Observatory, Tibet

    NASA Astrophysics Data System (ADS)

    Yao, Yongqiang; Zhou, Yunhe; Wang, Xiaohua; He, Jun; Zhou, Shu

    2015-08-01

    The Ali observatory, Tibet, is a promising new site identified through ten year site survey over west China, and it is of significance to establish rules of site protection during site development. The site protection program is described with five aspects: site monitoring, technical support, local government support, specific organization, and public education. The long-term sky brightness monitoring is ready with site testing instruments and basic for light pollution measurement; the monitoring also includes directions of main light sources, providing periodical reports and suggestions for coordinating meetings. The technical supports with institutes and manufacturers help to publish lighting standards and replace light fixtures; the research pays special attention to the blue-rich sources, which impact the important application of high altitude sites. An official leading group towards development and protection of astronomical resources has been established by Ali government; one of its tasks is to issue regulations against light pollution, including special restrictions of airport, mine, and winter heating, and to supervise lighting inspection and rectification. A site protection office under the official group and local astronomical society are organized by Ali observatory; the office can coordinate in government levels and promote related activities. A specific website operated by the protection office releases activity propaganda, evaluation results, and technical comparison with other observatories. Both the site protection office and Ali observatory take responsibility for public education, including popular science lectures, light pollution and energy conservation education. Ali Night Sky Park has been constructed and opens in 2014, and provides a popular place and observational experience. The establishment of Ali Observatory and Night Sky Park brings unexpected social influence, and the starry sky trip to Ali becomes a new format of culture

  4. Enhancing the AliEn Web Service Authentication

    NASA Astrophysics Data System (ADS)

    Zhu, Jianlin; Saiz, Pablo; Carminati, Federico; Betev, Latchezar; Zhou, Daicui; Mendez Lorenzo, Patricia; Grigoras, Alina Gabriela; Grigoras, Costin; Furano, Fabrizio; Schreiner, Steffen; Vladimirovna Datskova, Olga; Sankar Banerjee, Subho; Zhang, Guoping

    2011-12-01

    Web Services are an XML based technology that allow applications to communicate with each other across disparate systems. Web Services are becoming the de facto standard that enable inter operability between heterogeneous processes and systems. AliEn2 is a grid environment based on web services. The AliEn2 services can be divided in three categories: Central services, deployed once per organization; Site services, deployed on each of the participating centers; Job Agents running on the worker nodes automatically. A security model to protect these services is essential for the whole system. Current implementations of web server, such as Apache, are not suitable to be used within the grid environment. Apache with the mod_ssl and OpenSSL only supports the X.509 certificates. But in the grid environment, the common credential is the proxy certificate for the purpose of providing restricted proxy and delegation. An Authentication framework was taken for AliEn2 web services to add the ability to accept X.509 certificates and proxy certificates from client-side to Apache Web Server. The authentication framework could also allow the generation of access control policies to limit access to the AliEn2 web services.

  5. Sidi Ali Ou Azza (L4): A New Moroccan Fall

    NASA Astrophysics Data System (ADS)

    Chennaoui Aoudjehane, H.; Agee, C. B.; Aaranson, A.; Bouragaa, A.

    2016-08-01

    Sidi Ali Ou Azza is the latest meteorite fall in Morocco, it occurred on 28 July 2015 very close (about 40 km) to Tissint martian shergottite fall that occurred on 18 July 2011. It's one of the small group of 23 L4 ordinary chondrite falls.

  6. ALIS through the Looking Glass: Changing Perceptions of Performance Indicators.

    ERIC Educational Resources Information Center

    Williamson, John; And Others

    1992-01-01

    Follows up on a Williamson and Fitz-Gibbon article (1990) focusing on the impact of a performance indicator project, COMBSE (Confidential Measurement Based Self-Evaluation), on secondary school English departments. This article describes COMBSE's metamorphosis into another system, ALIS (A Level Information System), that has transcended the…

  7. ALI--A Digital Archive of DAISY Books

    ERIC Educational Resources Information Center

    Forsberg, Asa

    2007-01-01

    ALI is a project to develop an archive for talking books produced by the Swedish universities. The universities produce talking books from the mandatory literature for students with reading disabilities, including mostly journal articles, book chapters and texts written by teachers. The project group consists of librarians and co-ordinators for…

  8. Volcanic Rocks Collected With ROV Tiburon From Rodriguez Seamount, Located at the Continental Slope of the California Borderland

    NASA Astrophysics Data System (ADS)

    Davis, A. S.; Clague, D. A.; Paduan, J. B.

    2004-12-01

    Volcanic rocks were collected from Rodriguez Seamount at the outer margin off the Continental Borderland with MBARI's ROV Tiburon in October 2003 and April 2004. Six dives recovered lava and volcaniclastic samples from the deep flanks ( ˜2120 m) to the summit at 630 m. Whole rock compositions of plagioclase-olivine-clionpyroxene bearing lava samples are predominantly alkalic basalt (<8% MgO) and hawaiite with minor mugearite (MgO=1.5%). Glass compositions of pillow rims and of volcaniclastic fragments in breccia and bedded sandstone are predominantly hawaiite, mugearite and minor evolved alkalic basalt. The lava samples include one rhyolite and one basaltic andesite with subduction-related chemistry; they are probably erratics. Other clearly identifiable erratics include granite, quartzite, amphibolite, and bored, erosion-sculpted sandstone, resembling typical beach deposits. Most of these erratics are pebble- to small cobble-size and occur in conglomerate and crossbedded sandstone that surround the summit at a break in slope that most likely marks the shoreline when Rodriguez was an island. The lava outcrops on the gently domed platform of the summit are dense, oxidized àà-like flows without glassy rinds. Sulfur content of glass, collected from the flanks of the volcano, ranges from 1300 ppm of a glass inclusion in an olivine crystal to ˜160 ppm of volcaniclastic grains, indicating extensive degassing. Petrographically and chemically these lavas are virtually identical to those erupted on Miocene seamounts offshore central California (e.g. Davidson, Guide, Pioneer, Gumdrop seamounts, Davis et al, 2002) as well as Northeast Bank on the continental shelf south of Rodriguez and seamounts farther offshore from the Continental Borderland (e.g. Little Joe, San Marcos, San Juan seamounts, Clague et al, unpublished; Davis et al., 1995). Trace element abundances and ratios (e.g. LREE, Zr/Nb, Ta/Nb) also completely overlap with those from the other sites, suggesting

  9. The States and School Finance--After Rodriguez. A Background Paper for the National Governors' Conference and the National Legislative Conference.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO. Dept. of Research and Information Services.

    This publication examines a number of key issues and recent trends related to the general topic of school finance. Chapter 1 reviews several significant court cases challenging state school finance systems, including San Antonio Independent School District v. Rodriguez, Robinson v. Cahill, and Serrano v. Priest. Chapter 2 describes major new…

  10. Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis

    PubMed Central

    Nevarez, Lisette; Pogue, Robert; Krakow, Deborah; Cohn, Daniel H.

    2016-01-01

    The acrofacial dysostoses (AFD) are a genetically heterogeneous group of inherited disorders with craniofacial and limb abnormalities. Rodriguez syndrome is a severe, usually perinatal lethal AFD, characterized by severe retrognathia, oligodactyly and lower limb abnormalities. Rodriguez syndrome has been proposed to be a severe form of Nager syndrome, a non-lethal AFD that results from mutations in SF3B4, a component of the U2 small nuclear ribonucleoprotein particle (U2 snRNP). Furthermore, a case with a phenotype intermediate between Rodriguez and Nager syndromes has been shown to have an SF3B4 mutation. We identified heterozygosity for SF3B4 mutations in Rodriguez syndrome, confirming that the phenotype is a dominant disorder that is allelic with Nager syndrome. The mutations led to reduced SF3B4 synthesis and defects in mRNA splicing, primarily exon skipping. The mutations also led to reduced expression in growth plate chondrocytes of target genes, including the DLX5, DLX6, SOX9, and SOX6 transcription factor genes, which are known to be important for skeletal development. These data provide mechanistic insight toward understanding how SF3B4 mutations lead to the skeletal abnormalities observed in the acrofacial dysostoses. PMID:27622494

  11. Predictive criteria to study the pathogenesis of malaria-associated ALI/ARDS in mice.

    PubMed

    Ortolan, Luana S; Sercundes, Michelle K; Barboza, Renato; Debone, Daniela; Murillo, Oscar; Hagen, Stefano C F; Russo, Momtchilo; D' Império Lima, Maria Regina; Alvarez, José M; Amaku, Marcos; Marinho, Claudio R F; Epiphanio, Sabrina

    2014-01-01

    Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS) often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP) were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF) levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration) and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease.

  12. Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice

    PubMed Central

    Ortolan, Luana S.; Sercundes, Michelle K.; Debone, Daniela; Hagen, Stefano C. F.; D' Império Lima, Maria Regina; Alvarez, José M.; Marinho, Claudio R. F.; Epiphanio, Sabrina

    2014-01-01

    Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS) often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP) were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF) levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration) and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease. PMID:25276057

  13. Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS

    PubMed Central

    Pereira, Marcelo L. M.; Ortolan, Luana S.; Sercundes, Michelle K.; Debone, Daniela; Murillo, Oscar; Lima, Flávia A.

    2016-01-01

    Malaria is a serious disease, caused by the parasite of the genus Plasmodium, which was responsible for 440,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA/2 reproduces the clinical signs of ALI/ARDS in humans, when infected with Plasmodium berghei ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI/ARDS (MA-ALI/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI/ARDS when administered prior to the development of MA-ALI/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI/ARDS could be protective. However, the increased expression of HO-1 on the onset of MA-ALI/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI/ARDS in humans. PMID:27974865

  14. Seismic structure at the Kairei Hydrothermal vent field near the Rodriguez Triple Junction in the Indian Ocean

    NASA Astrophysics Data System (ADS)

    Takata, H.; Sato, T.; Imai, Y.; Mori, T.; Noguchi, Y.; Kono, A.; Yamada, T.; Shinohara, M.

    2014-12-01

    Central Indian Ridge is located at the north of the Rodriguez Triple Junction and shows slow-intermediate spreading rate. The Kairei hydrothermal Field (KHF) was discovered in the first segment of Central Indian Ridge near the Rodriguez Triple Junction. The vent fluid which is extruding at the KHF has higher H2 content compared with other hydrothermal vent fluid in the world. Although The KHF itself exists above a basaltic rock massif, gabbro and mafic rocks were discovered on the seafloor around the KHF. These deep-seated rocks may contribute to the high H2concentration of the Kairei vent fluid .To understand how gabbro and mafic rocks are uplifted and exhumed on the seafloor, we conducted a seismic refraction/reflection survey using ocean bottom seismograms (OBSs). We conducted the seismic refraction/reflection survey from January 27 to March 19 in 2013 using S/V Yokosuka of Jamstec. In the experiment, we used 21 OBSs, an air gun (G.I.gun) and a single channel steamer cable. We obtained 5 survey lines NNW-SSE direction parallel to the ridge axis, 5 lines E-W direction and 5 lines NNE-SSW direction. In addition to these lines, we acquired other 5 lines passing through the point above the KHF or Yokoniwa Rise, which is the north of the KHF. In analysis of refraction data, firstly, we estimated 2D velocity model under survey lines, which are parallel to the ridge axis, using the progressive model development method developed by Sato and Kennett (2000). Then, we constructed a 3D initial model and run the 3D tomographic method developed by Zelt and Barton (1998). The 1D velocity profile of the KHF seems to be similar to that of mid ocean ridges such as Mid Atlantic Ridge, East Pacific Rise. Seismic velocities under the KHF and Yokoniwa Rise reach about 6km/s at depth of 1~2 km below seafloor, probably indicating uplift of deep-seated rocks. In this presentation we will show 3D seismic structure of this area.

  15. Optical Turbulence Characterization by WRF model above Ali, Tibet

    NASA Astrophysics Data System (ADS)

    Wang, Hongshuai; Yao, Yongqiang; Liu, Liyong; Qian, Xuan; Yin, Jia

    2015-04-01

    Atmospheric optical turbulence modeling and forecast for astronomy is a relatively recent discipline, but has played important roles in site survey, optimization of large telescope observing tables, and in the applications of adaptive optics technique. The numerical approach, by using of meteorological parameters and parameterization of optical turbulence, can provide all the optical turbulence parameters related, such as C2n profile, coherent length, wavefront coherent time, seeing, isoplanatic angle, and so on. This is particularly interesting for searching new sites without the long and expensive site testing campaigns with instruments. Earlier site survey results by the site survey team of National Astronomical Observatories of China imply that the south-west Tibet, Ali, is one of the world best IR and sub-mm site. For searching the best site in Ali area, numerical approach by Weather and Research Forecasting (WRF) model had been used to evaluate the climatology of the optical turbulence. The WRF model is configured over a domain 200km×200km with 1km horizontal resolution and 65 vertical levels from ground to the model top(10millibars) in 2010. The initial and boundary conditions for the model are provided by the 1° × 1° Global Final Analysis data from NCEP. The distribution and seasonal variation of optical turbulence parameters over this area are presented.

  16. [Organization of care : specialized psychiatric clinic or general psychiatric clinic ? A debate between Louis Guérette and Jean-Pierre Rodriguez.].

    PubMed

    Robitaille, D

    1999-01-01

    The author reports on the opinions of doctors Louis Guérette and Jean-Pierre Rodriguez, both psychiatrists - one working at the Pavillon Notre-Dame of the Centre hospitalier universitaire de Montréal (CHUM) - the other at the Pavillon Albert-Prévost (PAP) of the Hôpital du Sacré-Coeur de Montréal, - on the place of specialized psychiatric clinics in the organization of care in psychiatry. Dr Guérette who practices general psychiatry thinks specialized clinics are not an appropriate mode of care delivery. Dr Rodriguez, answering to Dr Guérette's arguments, presents the organizational system of specialized clinics put in place at the PAP. The questions raised by the author and the psychiatrists' answers are reported. Finally, the author, a resident doctor in psychiatry, presents his own personal opinion on the issue.

  17. Muhammad Ali's Fighting Words: The Paradox of Violence in Nonviolent Rhetoric

    ERIC Educational Resources Information Center

    Gorsevski, Ellen W.; Butterworth, Michael L.

    2011-01-01

    While Muhammad Ali has been the subject of countless articles and books written by sports historians and journalists, rhetorical scholars have largely ignored him. This oversight is surprising given both the tradition of social movement scholarship within rhetorical studies and Ali's influential eloquence as a world renowned celebrity espousing…

  18. Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials.

    PubMed

    Janz, David R; Ware, Lorraine B

    2013-08-01

    Despite the high incidence and poor prognosis of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), it remains challenging to identify patients who are at highest risk of developing these syndromes, differentiate these syndromes from other causes of acute respiratory failure, and accurately prognosticate once the diagnosis is made. The identification and validation of biological markers of ALI has the potential to ameliorate these challenges by facilitating studies of therapies aimed at prevention, identifying patients more accurately that have ALI so they can benefit from evidence-based therapies and enrollment in clinical trials, and determining which patients are unlikely to have a positive outcome to guide therapeutic choices and trials of experimental rescue therapies. This article reviews the current state of biomarker research in ALI/ARDS. New methodologies for identification of novel biomarkers of ALI, including metabolomics, proteomics, gene expression, and genetic studies are also discussed.

  19. Brown Country: Johnny Rodriguez

    ERIC Educational Resources Information Center

    Vargas, Deborah R.

    2007-01-01

    The year 1972 was part of a dynamic period of Chicano politics and cultural production in South Texas. A few years earlier, in the Crystal City Revolts, Tejanos had moved to gain control of city and school board positions, events that resulted in the creation of the Raza Unida Party in 1970. Nineteen seventy-two also marked the beginning of the…

  20. The development of the hand-held dual-sensor ALIS

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Fujiwara, Jun; Takahashi, Kazunori

    2007-04-01

    Since 2002, we have developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. It makes possible to process the data afterwards, including migration. The migration processing drastically increases the quality of the image of the buried objects. The new system, we do not need any standard mark on the ground. Also, ALIS uses two different GPOR systems, including VNA (Vector Network Analyzer) based GPR and an Impulse GPR. VNA based GPR can provide better quality GPR images, although the impulse GPR is faster and light weight. ALIS evaluation tests were held in mine affected courtiers including Afghanistan, Croatia, Egypt and Cambodia. In the two-month evaluation test in Cambodia, ALIS worked without any problem. After some demonstrations and evaluation, we got many useful suggestions. Using these advises, we have modified the ALIS and it is now more easy to use. ALIS will be commercialized in 2007.

  1. Dynamic virtual AliEn Grid sites on Nimbus with CernVM

    NASA Astrophysics Data System (ADS)

    Harutyunyan, A.; Buncic, P.; Freeman, T.; Keahey, K.

    2010-04-01

    We describe the work on enabling one click deployment of Grid sites of AliEn Grid framework on the Nimbus 'science cloud' at the University of Chicago. The integration of computing resources of the cloud with the resource pool of AliEn Grid is achieved by leveraging two mechanisms: the Nimbus Context Broker developed at Argonne National Laboratory and the University of Chicago, and CernVM - a baseline virtual software appliance for LHC experiments developed at CERN. Two approaches of dynamic virtual AliEn Grid site deployment are presented.

  2. Hand-held dual-sensor ALIS and its evaluation tests

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Takahashi, Kazunori

    2008-04-01

    Since 2002, our research group at Tohoku University has developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. It makes possible to process the data afterwards, including migration. The migration processing drastically increases the quality of the image of the buried objects. ALIS evaluation test was conducted in Croatia in October 2007. Then after, we stared a half-year evaluation test of ALIS in QC test in Croatia in December 2007. This test will be conducted in various soil and environmental conditions in Croatia.

  3. Relocalization of nuclear ALY proteins to the cytoplasm by the tomato bushy stunt virus P19 pathogenicity protein.

    PubMed

    Uhrig, Joachim F; Canto, Tomas; Marshall, David; MacFarlane, Stuart A

    2004-08-01

    The P19 protein of tomato bushy stunt virus (TBSV) is a multifunctional pathogenicity determinant involved in suppression of posttranscriptional gene silencing, virus movement, and symptom induction. Here, we report that P19 interacts with the conserved RNA-binding domain of an as yet uncharacterized family of plant ALY proteins that, in animals, are involved in export of RNAs from the nucleus and transcriptional coactivation. We show that the four ALY proteins encoded by the Arabidopsis genome and two ALY proteins from Nicotiana benthamiana are localized to the nucleus. Moreover, and in contrast to animal ALY, all but one of the proteins are also in the nucleolus, with distinct subnuclear localizations. Infection of plants by TBSV or expression of P19 from Agrobacterium results in relocation of three of the six ALY proteins from the nucleus to the cytoplasm demonstrating specific targeting of the ALY proteins by P19. The differential effects on subcellular localization indicate that, in plants, the various ALY proteins may have different functions. Interaction with and relocalization of ALY is prevented by mutation of P19 at residues previously shown to be important for P19 function in plants. Down-regulation of expression of two N. benthamiana ALY genes by virus-induced gene silencing did not interfere with posttranscriptional gene silencing. Targeting of ALY proteins during TBSV infection may therefore be related to functions of P19 in addition to its silencing suppression activity.

  4. Aly/ REF, a factor for mRNA transport, activates RH gene promoter function.

    PubMed

    Suganuma, Hiroshi; Kumada, Maki; Omi, Toshinori; Gotoh, Takaya; Lkhagvasuren, Munkhtulga; Okuda, Hiroshi; Kamesaki, Toyomi; Kajii, Eiji; Iwamoto, Sadahiko

    2005-06-01

    The rhesus (Rh) blood group antigens are of considerable importance in transfusion medicine as well as in newborn or autoimmune hemolytic diseases due to their high antigenicity. We identified a major DNaseI hypersensitive site at the 5' flanking regions of both RHD and RHCE exon 1. A 34 bp fragment located at -191 to -158 from a translation start position, and containing the TCCCCTCCC sequence, was involved in enhancing promoter activity, which was assessed by luciferase reporter gene assay. A biotin-labelled 34 bp probe isolated an mRNA transporter protein, Aly/REF. The specific binding of Aly/REF to RH promoter in erythroid was confirmed by chromatin immunoprecipitation assay. The silencing of Aly/REF by siRNA reduced not only the RH promoter activity of the reporter gene but also transcription from the native genome. These facts provide second proof of Aly/REF as a transcription coactivator, initially identified as a coactivator for the TCRalpha enhancer function. Aly/REF might be a novel transcription cofactor for erythroid-specific genes.

  5. Preliminary studies on the extraction of Glycospanonins in Tongkat Ali extract

    NASA Astrophysics Data System (ADS)

    Abirame, S.; Sivakumar, K.; Chua, L. S.; Sarmidi, M. R.

    2016-06-01

    Eurycoma longifolia, locally known as Tongkat Ali, is a famous medicinal plant in the family of Simaroubaceae and well known for its aphrodisiac properties from its water extract. The root of E. longifolia is used to extract wide range bioactive components of Tongkat Ali. Previous works standardised Tongkat Ali extracts by measuring the concentration of eurycomanone, a quassinoid marker chemical, within the overall extract. There is a newer Malaysian standard that specifies that Tongkat Ali can be standardised to glycosaponin, thus it is desired to determine how extraction parameters such as particle size, extraction temperature, and solvent type affects the glycosaponin content in the extract. The overall study is aimed to determine how the extraction parameters affect the glycosaponin amount in extract. This paper presents the preliminary work where in this study the effect of particle size on overall extract and glycosaponin quantification method development is presented. A reflux extraction method was used to extract Tongkat Ali with a particle size of 0.5 mm, 1.0 mm and 2.0 mm of raw material to study effect of particle size on overall extract. Water and methanol were the two types of solvent used for extraction to study the quantity of glycosaponin.

  6. ALIS (Auroral Large Imaging System) used for optical observations of the meteor impact process

    NASA Astrophysics Data System (ADS)

    Brändström, U.; Gustavsson, B.; Steen, A.; Pellinen-Wannberg, Asta

    2001-11-01

    This paper outlines a possibly new use of the Auroral Large Imaging System (ALIS) for studies of differential ablation phenomena in meteor trails. By simultaneous imaging from up to six stations, the altitude distribution of the meteor trails could be triangulated, while some stations simultaneously image the trails in for example the sodium (5893 Å) and calcium (4227 Å) lines. ALIS was primarily designed for auroral studies, but has also been used for studies of heater-induced airglow, polar stratospheric clouds as well as other phenomena. The system consits of six unmanned remote-controlled observation stations located in northern Sweden.

  7. Mechanism and early intervention research on ALI during emergence surgery of Stanford type-A AAD

    PubMed Central

    Cheng, Yi; Jin, Mu; Dong, Xiuhua; Sun, Lizhong; Liu, Jing; Wang, Rong; Yang, Yanwei; Lin, Peirong; Hou, Siyu; Ma, Yuehua; Wang, Yuefeng; Pan, Xudong; Lu, Jiakai; Cheng, Weiping

    2016-01-01

    Abstract Background: Stanford type-A acute aortic dissection (AAD) is a severe cardiovascular disease demonstrating the characteristics of acute onset and rapid development, with high morbidity and mortality. The available evidence shows that preoperative acute lung injury (ALI) induced by Stanford type-A AAD is a frequent and important cause for a number of untoward consequences. However, there is no study assessing the incidence of preoperative ALI and its independent determinants before Standford type-A AAD surgery in Chinese adult patients. Methods/design: This is a prospective, double-blind, signal-center clinical trial. We will recruit 130 adult patients undergoing Stanford type-A AAD surgery. The incidence of preoperative ALI will be evaluated. Perioperative clinical baselines and serum variables including coagulation, fibrinolysis, inflammatory, reactive oxygen species, and endothelial cell function will be assayed. The independent factors affecting the occurrence of preoperative ALI will be identified by multiple logistic regression analysis. Trial registration: ClinicalTrials.gov (https://register.clinicaltrials.gov/), Registration number NCT01894334. PMID:27759648

  8. Cross calibration of the Landsat-7 ETM+ and EO-1 ALI sensor

    USGS Publications Warehouse

    Chander, G.; Meyer, D.J.; Helder, D.L.

    2004-01-01

    As part of the Earth Observer 1 (EO-1) Mission, the Advanced Land Imager (ALI) demonstrates a potential technological direction for Landsat Data Continuity Missions. To evaluate ALI's capabilities in this role, a cross-calibration methodology has been developed using image pairs from the Landsat-7 (L7) Enhanced Thematic Mapper Plus (ETM+) and EO-1 (ALI) to verify the radiometric calibration of ALI with respect to the well-calibrated L7 ETM+ sensor. Results have been obtained using two different approaches. The first approach involves calibration of nearly simultaneous surface observations based on image statistics from areas observed simultaneously by the two sensors. The second approach uses vicarious calibration techniques to compare the predicted top-of-atmosphere radiance derived from ground reference data collected during the overpass to the measured radiance obtained from the sensor. The results indicate that the relative sensor chip assemblies gains agree with the ETM+ visible and near-infrared bands to within 2% and the shortwave infrared bands to within 4%.

  9. The evaluation test of hand-held dual-sensor ALIS in Croatia and Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki; Takahashi, Kazunori

    2007-04-01

    We are developing a new hand-held land mine detection dual-sensor (ALIS) which is equipped with a metal detector and a GPR. ALIS is equipped with a sensor tracking system, which can record the GPR and Metal detector signal with its location. It makes possible to process the data after the data was acquired, including migration. The migration processing drastically increases the quality of the images of the buried objects. Evaluation test of ALIS has been conducted in several test sites. In February 2006, a one-month evaluation test was conducted in Croatia, and in October- December 2006, a two-month evaluation test was conducted in Croatia. Since the dual-sensor is a new landmine detection sensor, and the conventional evaluation procedure developed for metal detectors cannot directly be applied for the dual sensor. In Croatia, the detection probability was comparable to that by a metal detector operated by local deminers. In addition, we showed that ALIS provides image of buried objects by GPR, which can be used for identification. Therefore, their performances were sufficiently high. Then the test was also conducted in Cambodia. The test was carried out by 2 local deminers independently, which allows studying the influence of different operators and increases the statistical value of the results.

  10. Deployment of dual-sensor ALIS for humanitarian demining in Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, M.; Takahashi, K.

    2013-06-01

    We are in the process of developing a high-resolution landmine scanning system "ALIS" which produces horizontal slices of the shallow subsurface for visualization of buried explosives and inert clutter. As many AP mines contain minimum amounts of metal, metal detectors need to be combined with a complimentary subsurface imaging sensor. Ground Penetrating Radar (GPR) is widely accepted for subsurface sensing in the fields of geology, archaeology and utility detection. The demining application requires real-time imaging results with centimetre resolution in a highly portable package. The key requirement for sharp images of the subsurface is the precise tracking of the geophysical sensor(s) during data collection. We should also notice that GPR system is a very wide band radar system, and equivalent to UWB radar, which has recently been developed for short-range high-accuracy radar. We are testing simplified but effective signal processing for imaging mines. We are currently testing a dual sensor ALIS which is a realtime sensor tracking system based on a CCD camera and image processing. In this paper we introduce the GPR systems which we have developed for detection of buried antipersonnel mines and small size explosives. ALIS has been deployed in Cambodia since 2009 and detected more than 70 mines in mine fields, and returned more than 13ha cleaned fields to local farmers. We also report the current status of ALIS in Cambodia.

  11. Traumatic forequarter amputation associated acute lung injury (ALI): report of one case.

    PubMed

    Liang, K; Gan, X; Deng, Z

    2012-07-01

    One case of traumatic forequarter amputation associated acute lung injury (ALI) was presented. A discussion reviewing the treatment guidelines for this devastating injury, and pointing out the importance of supporting the lung and preventing the development of acute respiratory distress syndrome (ARDS) was included.

  12. 76 FR 62494 - Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Ibrahim `Awad Ibrahim al-Badri al-Samarrai, Also Known as Ibrahim Awwad Ibrahim al-Samarra'I, Also Known as Dr. Ibrahim Awwad...

  13. Simultaneous quantitation of six major quassinoids in Tongkat Ali dietary supplements by liquid chromatography with tandem mass spectrometry.

    PubMed

    Han, Young Min; Jang, Moonhee; Kim, In Sook; Kim, Seung Hyun; Yoo, Hye Hyun

    2015-07-01

    Tongkat Ali (Eurycoma longifolia) is one of the most popular traditional herbs in Southeast Asia and generally consumed as forms of dietary supplements, tea, or drink additives for coffee or energy beverages. In this study, the liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of six major quassinoids of Tongkat Ali (eurycomanone, 13,21-dihydroeurycomanone, 13α(21)-epoxyeurycomanone, 14,15β-dihydroxyklaineanone, eurycomalactone, and longilactone) was developed and validated. Using the developed method, the content of the six quassinoids was measured in Tongkat Ali containing dietary supplement tablets or capsules, and the resulting data were used to confirm the presence of Tongkat Ali in those products. Among the six quassinoids, eurycomanone was the most abundant quassinoid in all samples tested. The developed method would be useful for the quality assessment of Tongkat Ali containing dietary supplements.

  14. ASTER, ALI and Hyperion sensors data for lithological mapping and ore minerals exploration.

    PubMed

    Beiranvand Pour, Amin; Hashim, Mazlan

    2014-01-01

    This paper provides a review of the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Advanced Land Imager (ALI), and Hyperion data and applications of the data as a tool for ore minerals exploration, lithological and structural mapping. Spectral information extraction from ASTER, ALI, and Hyperion data has great ability to assist geologists in all disciplines to map the distribution and detect the rock units exposed at the earth's surface. The near coincidence of Earth Observing System (EOS)/Terra and Earth Observing One (EO-1) platforms allows acquiring ASTER, ALI, and Hyperion imagery of the same ground areas, resulting accurate information for geological mapping applications especially in the reconnaissance stages of hydrothermal copper and gold exploration, chromite, magnetite, massive sulfide and uranium ore deposits, mineral components of soils and structural interpretation at both regional and district scales. Shortwave length infrared and thermal infrared bands of ASTER have sufficient spectral resolution to map fundamental absorptions of hydroxyl mineral groups and silica and carbonate minerals for regional mapping purposes. Ferric-iron bearing minerals can be discriminated using six unique wavelength bands of ALI spanning the visible and near infrared. Hyperion visible and near infrared bands (0.4 to 1.0 μm) and shortwave infrared bands (0.9 to 2.5 μm) allowed to produce image maps of iron oxide minerals, hydroxyl-bearing minerals, sulfates and carbonates in association with hydrothermal alteration assemblages, respectively. The techniques and achievements reviewed in the present paper can further introduce the efficacy of ASTER, ALI, and Hyperion data for future mineral and lithological mapping and exploration of the porphyry copper, epithermal gold, chromite, magnetite, massive sulfide and uranium ore deposits especially in arid and semi-arid territory.

  15. Involvement of CD4⁺ Foxp3⁺ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice.

    PubMed

    Tiwananthagorn, Saruda; Iwabuchi, Kazuya; Ato, Manabu; Sakurai, Tatsuya; Kato, Hirotomo; Katakura, Ken

    2012-01-01

    Visceral leishmaniasis (VL) is a chronic and fatal disease in humans and dogs caused by the intracellular protozoan parasites, Leishmania donovani and L. infantum (L. chagasi). Relapse of disease is frequent in immunocompromised patients, in which the number of VL cases has been increasing recently. The present study is aimed to improve the understanding of mechanisms of L. donovani persistence in immunocompromised conditions using alymphoplastic aly/aly mice. Hepatic parasite burden, granuloma formation and induction of regulatory T cells were determined for up to 7 months after the intravenous inoculation with L. donovani promastigotes. While control aly/+ mice showed a peak of hepatic parasite growth at 4 weeks post infection (WPI) and resolved the infection by 8 WPI, aly/aly mice showed a similar peak in hepatic parasite burden but maintained persistent in the chronic phase of infection, which was associated with delayed and impaired granuloma maturation. Although hepatic CD4(+)Foxp3(+) but not CD8(+)Foxp3(+) T cells were first detected at 4 WPI in both strains of mice, the number of CD4(+)Foxp3(+) T cells was significantly increased in aly/aly mice from 8 WPI. Immunohistochemical analysis demonstrated the presence of Foxp3(+) T cells in L. donovani-induced hepatic granulomas and perivascular neo-lymphoid aggregates. Quantitative real-time PCR analysis of mature granulomas collected by laser microdissection revealed the correlation of Foxp3 and IL-10 mRNA level. Furthermore, treatment of infected aly/aly mice with anti-CD25 or anti-FR4 mAb resulted in significant reductions in both hepatic Foxp3(+) cells and parasite burden. Thus, we provide the first evidence that CD4(+)Foxp3(+) Tregs mediate L. donovani persistence in the liver during VL in immunodeficient murine model, a result that will help to establish new strategies of immunotherapy against this intracellular protozoan pathogen.

  16. An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography.

    PubMed

    Yang, Chang-Tong; Chandrasekharan, Prashant; He, Tao; Poh, Zihan; Raju, Anandhkumar; Chuang, Kai-Hsiang; Robins, Edward G

    2014-01-01

    An intravascular MRI contrast agent Gd(DO3A-Lys), Gadolinium(III) (2,2',2″-(10-(3-(5-benzamido-6-methoxy-6-oxohexylamino)-3-oxopropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate), has been studied for tumor angiography based on its high relaxivity and long blood half-life. The preparation procedures of the contrast agent have been modified in order to achieve higher yield and improve the synthetic reproducibility. High relaxivity of Gd(DO3A-Lys) has been confirmed by measurements at 3 T, 7 T and 9.4 T magnetic fields. The relaxivity-dependent albumin binding study indicated that Gd(DO3A-Lys) partially bound to albumin protein. In vitro cell viability in HK2 cell indicated low cytotoxicity of Gd(DO3A-Lys) up to 1.2 mM [Gd] concentration. In vivo toxicity studies demonstrated no toxicity of Gd(DO3A-Lys) on kidney tissues up to 0.2 mM [Gd]. While the toxicity on liver tissue was not observed at low dosage (1.0 mM [Gd]), Gd(DO3A-Lys) cause certain damage on hepatic tissue at high dosage (2.0 mM [Gd]). The DO3A-Lys has been labeled with (68)Ga radioisotope for biodistribution studies. (68)Ga(DO3A-Lys) has high uptake in both HT1080 and U87MG xenograft tumors, and has high accumulation in blood. Contrast-enhanced MR angiography (CE-MRA) in mice bearing U87MG xenograft tumor demonstrated that Gd(DO3A-Lys) could enhance vascular microenvironment around the tumor, and displays promising characteristics of an MRI contrast agent for tumor angiography.

  17. Plant proteins, minerals and trace elements of Eurycoma longifolia (Tongkat Ali).

    PubMed

    Chua, Lee Suan; Abdul-Rahman, Nurulaini; Rosidi, Bustanur; Lee, Chew Tin

    2013-03-01

    A water extraction method has been used to extract plant proteins from the roots of Eurycoma longifolia harvested from Perak and Pahang, Malaysia. On the basis of the spectroscopic Bradford assay, Tongkat Ali Perak and Pahang contained 0.3868 and 0.9573 mg mL(-1) of crude protein, respectively. The crude proteins were separated by one dimensional 15% sodium dodecyl sulphate polyacrylamide gel electrophoresis into two (49.8 and 5.5 kD) and four (49.8, 24.7, 21.1 and 5.5 kD) protein spots for Tongkat Ali Perak and Pahang, respectively. Isoleucine was present in the highest concentration significantly. Both plant samples showed differences in the mineral and trace element profiles, but the minerals calcium, magnesium and potassium were present in the highest concentration. The highly concerned toxic metals such as arsenic and lead were not detected.

  18. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance.

    PubMed

    Bhat, Rajeev; Karim, A A

    2010-10-01

    Eurycoma longifolia Jack is an herbal medicinal plant of South-East Asian origin, popularly recognized as 'Tongkat Ali.' The plant parts have been traditionally used for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial and anti-pyretic activities, which have also been proved scientifically. The plant parts are rich in various bioactive compounds (like eurycomaoside, eurycolactone, eurycomalactone, eurycomanone, and pasakbumin-B) among which the alkaloids and quassinoids form a major portion. Even though toxicity and safety evaluation studies have been pursued, still a major gap exists in providing scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumer's safety. The present review aims at reviewing the research works undertaken till date, on this plant in order to provide sufficient baseline information for future works and for commercial exploitation.

  19. Stress field during early magmatism in the Ali Sabieh Dome, Djibouti, SE Afar rift

    NASA Astrophysics Data System (ADS)

    Sue, Christian; Le Gall, Bernard; Daoud, Ahmed Mohamed

    2014-09-01

    The so-called Ali Sabieh range, SE Afar rift, exhibits an atypical antiform structure occurring in the overall extensional tectonic context of the Afar triple junction. We dynamically analyzed the brittle deformation of this specific structural high using four different methods in order to better constrain the tectonic evolution of this key-area in the Afar depression. Paleostress inversions appear highly consistent using the four methods, which a posteriori validates this approach. Computed paleostress fields document two major signals: an early E-W extensional field, and a later transcurrent field, kinematically consistent with the previous one. The Ali Sabieh range may have evolved continuously during Oligo-Miocene times from large-scale extensional to transcurrent tectonism, as the result of probable local stress permutation between σ1 and σ2 stress axes.

  20. ALIS: a multistation imaging facility with possibilities for future VI applications

    NASA Astrophysics Data System (ADS)

    Brandstrom, Urban; Steen, Ake; Rydesater, Peter; Gustavsson, Bjorn; Aso, T.

    1999-03-01

    ALIS (Auroral Large Imaging System) is an imaging facility in Northern Sweden. The system consists of six unmanned, remote controlled stations. Each station has a high performance CCD imager, and some stations also have other scientific instrumentation (e.g. pulsation magnetometers). ALIS is capable of producing large amounts of data in a short time. For that reason, novel (AI/VI) techniques for data analysis, are of high priority in order to be able to handle the large data sets. In this paper we will try to describe the current implementation and address the questions of how to interface AI/VI applications to an existing multi station research facility, in terms of real- time experiment control, selective imaging, real-time data analysis, etc.

  1. JAliEn - A new interface between the AliEn jobs and the central services

    NASA Astrophysics Data System (ADS)

    Grigoras, A. G.; Grigoras, C.; Pedreira, M. M.; Saiz, P.; Schreiner, S.

    2014-06-01

    Since the ALICE experiment began data taking in early 2010, the amount of end user jobs on the AliEn Grid has increased significantly. Presently 1/3 of the 40K CPU cores available to ALICE are occupied by jobs submitted by about 400 distinct users, individually or in organized analysis trains. The overall stability of the AliEn middleware has been excellent throughout the 3 years of running, but the massive amount of end-user analysis and its specific requirements and load has revealed few components which can be improved. One of them is the interface between users and central AliEn services (catalogue, job submission system) which we are currently re-implementing in Java. The interface provides persistent connection with enhanced data and job submission authenticity. In this paper we will describe the architecture of the new interface, the ROOT binding which enables the use of a single interface in addition to the standard UNIX-like access shell and the new security-related features.

  2. Securing the AliEn File Catalogue - Enforcing authorization with accountable file operations

    NASA Astrophysics Data System (ADS)

    Schreiner, Steffen; Bagnasco, Stefano; Sankar Banerjee, Subho; Betev, Latchezar; Carminati, Federico; Vladimirovna Datskova, Olga; Furano, Fabrizio; Grigoras, Alina; Grigoras, Costin; Mendez Lorenzo, Patricia; Peters, Andreas Joachim; Saiz, Pablo; Zhu, Jianlin

    2011-12-01

    The AliEn Grid Services, as operated by the ALICE Collaboration in its global physics analysis grid framework, is based on a central File Catalogue together with a distributed set of storage systems and the possibility to register links to external data resources. This paper describes several identified vulnerabilities in the AliEn File Catalogue access protocol regarding fraud and unauthorized file alteration and presents a more secure and revised design: a new mechanism, called LFN Booking Table, is introduced in order to keep track of access authorization in the transient state of files entering or leaving the File Catalogue. Due to a simplification of the original Access Envelope mechanism for xrootd-protocol-based storage systems, fundamental computational improvements of the mechanism were achieved as well as an up to 50% reduction of the credential's size. By extending the access protocol with signed status messages from the underlying storage system, the File Catalogue receives trusted information about a file's size and checksum and the protocol is no longer dependent on client trust. Altogether, the revised design complies with atomic and consistent transactions and allows for accountable, authentic, and traceable file operations. This paper describes these changes as part and beyond the development of AliEn version 2.19.

  3. Comparison of EO1 Landsat-7 ETM+ and EO-1 ALI images over Rochester, New York

    NASA Astrophysics Data System (ADS)

    Pedelty, Jeffrey A.; Morisette, Jeffrey T.; Smith, James A.

    2002-08-01

    We present a comparison of images from the ETM+ sensor on Landsat-7 and the ALI instrument on EO-1 over a test site in Rochester, NY. The site contains a variety of features, ranging from water of varying depths, deciduous/coniferous forest, grass fields, to urban areas. The nearly coincident cloud-free images were collected just one minute apart on 25 August, 2001. We atmospherically corrected each image with the 6S atmosphere model, using aerosol optical thickness and water vapor column density measured by a Cimel sun photometer within the Aerosol Robotic Network (Aeronet), along with ozone density derived from NCEP data. We present three-color composites from each instrument that show excellent qualitative agreement. We present ETM+ and ALI reflectance spectra for water, grass, and urban targets. We make a more detailed comparison for our forest site, where we use measured geometric and optical properties as input to the SAIL canopy reflectance model, which we compare to the ETM+, ALI, and EO-1 Hyperion reflectance spectra.

  4. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS.

    PubMed

    Rajasekaran, Surender; Sanfilippo, Dominic; Shoemaker, Allen; Curtis, Scott; Zuiderveen, Sandra; Ndika, Akunne; Stoiko, Michael; Hassan, Nabil

    2012-01-01

    Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children's Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4 ± 7.5 to 116.5 ± 8.8 in transfused but increased from 148.0 ± 8.0 to 190.4 ± 17.8 (P < 0.001) in control. OI increased in the transfused from 11.7 ± 0.9 to 18.7 ± 1.6 but not in control. Ventilator days in the transfused were 15.6 ± 1.7 versus 9.5 ± 0.6 days in control (P < 0.001). There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6-5.6 Fisher exact P < 0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs.

  5. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS

    PubMed Central

    Rajasekaran, Surender; Sanfilippo, Dominic; Shoemaker, Allen; Curtis, Scott; Zuiderveen, Sandra; Ndika, Akunne; Stoiko, Michael; Hassan, Nabil

    2012-01-01

    Introduction. In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery. Hypothesis. We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children's Hospital between January 1st 2008 and December 31st 2009. Results. Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from 135.4 ± 7.5 to 116.5 ± 8.8 in transfused but increased from 148.0 ± 8.0 to 190.4 ± 17.8 (P < 0.001) in control. OI increased in the transfused from 11.7 ± 0.9 to 18.7 ± 1.6 but not in control. Ventilator days in the transfused were 15.6 ± 1.7 versus 9.5 ± 0.6 days in control (P < 0.001). There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6–5.6 Fisher exact P < 0.282. Conclusion. This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs. PMID:22957223

  6. Summary of Current Radiometric Calibration Coefficients for Landsat MSS, TM, ETM+, and EO-1 ALI Sensors

    NASA Technical Reports Server (NTRS)

    Chander, Gyanesh; Markham, Brian L.; Helder, Dennis L.

    2009-01-01

    This paper provides a summary of the current equations and rescaling factors for converting calibrated Digital Numbers (DNs) to absolute units of at-sensor spectral radiance, Top-Of- Atmosphere (TOA) reflectance, and at-sensor brightness temperature. It tabulates the necessary constants for the Multispectral Scanner (MSS), Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+), and Advanced Land Imager (ALI) sensors. These conversions provide a basis for standardized comparison of data in a single scene or between images acquired on different dates or by different sensors. This paper forms a needed guide for Landsat data users who now have access to the entire Landsat archive at no cost.

  7. The Persian legend of ophthalmology: Ali Asghar Khodadoust and his everlasting lines.

    PubMed

    Sajjadi, Sepideh; Fesharaki, Hamid; Abtahi, Zahra-Alsadat; Murray, Richard T; Fereidan-Esfahani, Mahboobeh; Mazloumi, Mehdi; Abtahi, Seyed-Hossein

    2013-06-01

    This is a brief celebratory overview of the fruitful life and scientific endeavors of Professor Ali Asghar Khodadoust (b.1935), a world renowned ophthalmologist, Persian icon of modern ophthalmology and an international pioneer of eye research. The global reputation of Dr. Khodadoust is rooted in his extensive studies on corneal diseases and transplantation biology. As a result of his truly deserved world renown, several famous American ophthalmologists have recognized him as the world's best corneal graft surgeon. Due to his exceptionally impressive achievements in this field, a clinical finding has been named in his honor, the "Khodadoust rejection line", a sign indicative of a chronic focal transplant reaction.

  8. Summary of current radiometric calibration coefficients for Landsat MSS, TM, ETM+, and EO-1 ALI sensors

    USGS Publications Warehouse

    Chander, G.; Markham, B.L.; Helder, D.L.

    2009-01-01

    This paper provides a summary of the current equations and rescaling factors for converting calibrated Digital Numbers (DNs) to absolute units of at-sensor spectral radiance, Top-Of-Atmosphere (TOA) reflectance, and at-sensor brightness temperature. It tabulates the necessary constants for the Multispectral Scanner (MSS), Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+), and Advanced Land Imager (ALI) sensors. These conversions provide a basis for standardized comparison of data in a single scene or between images acquired on different dates or by different sensors. This paper forms a needed guide for Landsat data users who now have access to the entire Landsat archive at no cost.

  9. Simulation of EO-1 Hyperion Data from ALI Multispectral Data Based on the Spectral Reconstruction Approach.

    PubMed

    Liu, Bo; Zhang, Lifu; Zhang, Xia; Zhang, Bing; Tong, Qingxi

    2009-01-01

    Data simulation is widely used in remote sensing to produce imagery for a new sensor in the design stage, for scale issues of some special applications, or for testing of novel algorithms. Hyperspectral data could provide more abundant information than traditional multispectral data and thus greatly extend the range of remote sensing applications. Unfortunately, hyperspectral data are much more difficult and expensive to acquire and were not available prior to the development of operational hyperspectral instruments, while large amounts of accumulated multispectral data have been collected around the world over the past several decades. Therefore, it is reasonable to examine means of using these multispectral data to simulate or construct hyperspectral data, especially in situations where hyperspectral data are necessary but hard to acquire. Here, a method based on spectral reconstruction is proposed to simulate hyperspectral data (Hyperion data) from multispectral Advanced Land Imager data (ALI data). This method involves extraction of the inherent information of source data and reassignment to newly simulated data. A total of 106 bands of Hyperion data were simulated from ALI data covering the same area. To evaluate this method, we compare the simulated and original Hyperion data by visual interpretation, statistical comparison, and classification. The results generally showed good performance of this method and indicated that most bands were well simulated, and the information both preserved and presented well. This makes it possible to simulate hyperspectral data from multispectral data for testing the performance of algorithms, extend the use of multispectral data and help the design of a virtual sensor.

  10. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

    PubMed Central

    2013-01-01

    Background Eurycoma longifolia is a medicinal plant commonly called tongkat ali (TA) and “Malaysian ginseng.” TA roots are a traditional “anti-aging” remedy and modern supplements are intended to improve libido, energy, sports performance and weight loss. Previous studies have shown properly-standardized TA to stimulate release of free testosterone, improve sex drive, reduce fatigue, and improve well-being. Methods We assessed stress hormones and mood state in 63 subjects (32 men and 31 women) screened for moderate stress and supplemented with a standardized hot-water extract of TA root (TA) or Placebo (PL) for 4 weeks. Analysis of variance (ANOVA) with significance set at p < 0.05 was used to determine differences between groups. Results Significant improvements were found in the TA group for Tension (−11%), Anger (−12%), and Confusion (−15%). Stress hormone profile (salivary cortisol and testosterone) was significantly improved by TA supplementation, with reduced cortisol exposure (−16%) and increased testosterone status (+37%). Conclusion These results indicate that daily supplementation with tongkat ali root extract improves stress hormone profile and certain mood state parameters, suggesting that this “ancient” remedy may be an effective approach to shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training. PMID:23705671

  11. Magma-driven antiform structures in the Afar rift: The Ali Sabieh range, Djibouti

    NASA Astrophysics Data System (ADS)

    Le Gall, Bernard; Daoud, Mohamed Ahmed; Maury, René C.; Rolet, Joël; Guillou, Hervé; Sue, Christian

    2010-06-01

    The Ali Sabieh Range, SE Afar, is an antiform involving Mesozoic sedimentary rocks and synrift volcanics. Previous studies have postulated a tectonic origin for this structure, in either a contractional or extensional regime. New stratigraphic, mapping and structural data demonstrate that large-scale doming took place at an early stage of rifting, in response to a mafic laccolithic intrusion dated between 28 and 20 Ma from new K-Ar age determinations. Our 'laccolith' model is chiefly supported by: (i) the geometry of the intrusion roof, (ii) the recognition of roof pendants in its axial part, and (iii) the mapping relationships between the intrusion, the associated dyke-sill network, and the upper volcanic/volcaniclastic sequences. The laccolith is assumed to have inflated with time, and to have upwardly bent its sedimentary roof rocks. From the architecture of the ˜1 km-thick Mesozoic overburden sequences, ca. 2 km of roof lifting are assumed to have occurred, probably in association with reactivated transverse discontinuities. Computed paleostress tensors indicate that the minimum principal stress axis is consistently horizontal and oriented E-W, with a dominance of extensional versus strike-slip regimes. The Ali Sabieh laccolith is the first regional-scale magma-driven antiform structure reported so far in the Afro-Arabian rift system.

  12. STS-45 Earth observation of the Persian Gulf and the island of Abu Ali

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-45 Earth observation taken aboard Atlantis, Orbiter Vehicle (OV) 104, is of the northern reaches of the Persian Gulf with the sunglint pattern centered on the Saudi Arabian island of Abu Ali. Bright features along the coast are thought to be deposits of oil, released from a terminal offshore of Kuwait during the recent Persian Gulf War. Further up the coast, in Kuwait, the black, oil-soaked desert surrounding the site of the oil well fires is clearly visible. View was taken from an altitude of 160 nautical miles with OV-104 located at 28 degrees north and 52.8 degrees east. During the STS-45 mission, an international survey team focused on oil contamination of the shallow-water habitants in the area north of Abu Ali Island. Crewmembers contacted the NOAA survey vessel, the R/V Mt. Mitchell, several times and photographed water color and sunglint within the study area and throughout the entire Persian Gulf. These photographic data are expected to aid the Persian Gulf researchers in

  13. Divergence of the gene aly in experimentally evolved cytoraces, the members of the nasuta-albomicans complex of Drosophila.

    PubMed

    Radhika, P N; Ramachandra, N B

    2014-08-01

    We generated cytoraces by crossing the chromosomal races (Drosophila nasuta nasuta and Drosophila nasuta albomicans) of the nasuta subgroup of Drosophila and maintained the offspring over many generations through sibling mating. These cytoraces, along with their parents, are members of the nasuta-albomicans complex of Drosophila. The gene always early (aly) is one of the rapidly evolving genes in the genus Drosophila and plays a central role in regulating meiosis. Here we examined the rate of molecular evolution of aly in cytoraces of Drosophila and demonstrated that the rate of substitutions amongst cytoraces is around eight times greater than their parents and even amongst species of subgenera. Thus, the presence of positive selection in the laboratory-derived cytoraces based on the analysis of the synonymous and nonsynonymous substitution rates of aly suggests the rapid evolution in cytoraces.

  14. Land cover mapping with emphasis to burnt area delineation using co-orbital ALI and Landsat TM imagery

    NASA Astrophysics Data System (ADS)

    Petropoulos, George P.; Kontoes, Charalambos C.; Keramitsoglou, Iphigenia

    2012-08-01

    In this study, the potential of EO-1 Advanced Land Imager (ALI) radiometer for land cover and especially burnt area mapping from a single image analysis is investigated. Co-orbital imagery from the Landsat Thematic Mapper (TM) was also utilised for comparison purposes. Both images were acquired shortly after the suppression of a fire occurred during the summer of 2009 North-East of Athens, the capital of Greece. The Maximum Likelihood (ML), Artificial Neural Networks (ANNs) and Support Vector Machines (SVMs) classifiers were parameterised and subsequently applied to the acquired satellite datasets. Evaluation of the land use/cover mapping accuracy was based on the error matrix statistics. Also, the McNemar test was used to evaluate the statistical significance of the differences between the approaches tested. Derived burnt area estimates were validated against the operationally deployed Services and Applications For Emergency Response (SAFER) Burnt Scar Mapping service. All classifiers applied to either ALI or TM imagery proved flexible enough to map land cover and also to extract the burnt area from other land surface types. The highest total classification accuracy and burnt area detection capability was returned from the application of SVMs to ALI data. This was due to the SVMs ability to identify an optimal separating hyperplane for best classes' separation that was able to better utilise ALI's advanced technological characteristics in comparison to those of TM sensor. This study is to our knowledge the first of its kind, effectively demonstrating the benefits of the combined application of SVMs to ALI data further implying that ALI technology may prove highly valuable in mapping burnt areas and land use/cover if it is incorporated into the development of Landsat 8 mission, planned to be launched in the coming years.

  15. FAMoS - an information service on the usage of data files in AliEn

    NASA Astrophysics Data System (ADS)

    Abramyan, A.; Betev, L.; Buncic, P.; Grigoras, C.; Grigoryan, A.; Manukyan, N.; Pedreira, M. M.; Saiz, P.

    2015-05-01

    The File Access Monitoring Service (FAMoS) leverages the information stored in the central AliEn file catalogue, which describes every file in a Unix-like directory structure, as well as metadata on file location and its replicas. In addition, it uses the access information provided by a set of API servers, used by all Grid clients to access the catalogue. The main functions of FAMoS are to sort the file accesses by logical groups, access time, user and storage element. The collected data identifies rarely used groups of files, as well as those with high popularity over different time periods. This information can be further used to optimize file distribution and replication factors, thus increasing the data processing efficiency. The paper describes the FAMoS structure and user interface and presents the results obtained in one year of service operation.

  16. First results of auroral tomography from ALIS-Japan multi-station observations in March, 1995

    NASA Astrophysics Data System (ADS)

    Aso, T.; Ejiri, M.; Urashima, A.; Miyaoka, H.; Steen, Å.; Brändström, U.; Gustavsson, B.

    1998-01-01

    Auroral tomography observations have been carried out in March, 1995, as a joint international campaign between Sweden and Japan. Three unmanned Swedish ALIS stations (Kiruna, Merasjärvi, Tjautjas) and two Japanese JICCD sites (Abisko, Nikkaluokta), geographically separated by about 50 km at higher latitudes, were operated to capture multi-station monochromatic tomography images at 557.7 nm wavelength using CCD cameras. All cameras were pointing to one of the predetermined directions to secure a common field of view. Several images of auroral arcs, mostly for the core region right above Kiruna, have synchronously been taken by the multi-station imaging system. Tomographic inversion analysis for four-point images was carried out using the algebraic reconstruction technique. Reconstructions of a curved arc and of a double arc system suggest promising application of this technique to the retrieval of three-dimensional auroral luminosity.

  17. Ali Observatory in Tibet: a unique northern site for future CMB ground-based observations

    NASA Astrophysics Data System (ADS)

    Su, Meng

    2015-08-01

    Ground-based CMB observations have been performed at the South Pole and the Atacama desert in Chile. However, a significant fraction of the sky can not be observed from just these two sites. For a full sky coverage from the ground in the future, a northern site for CMB observation, in particular CMB polarization, is required. Besides the long-thought site in Greenland, the high altitude Tibet plateau provides another opportunity. I will describe the Ali Observatory in Tibet, located at N32°19', E80°01', as a potential site for ground-based CMB observations. The new site is located on almost 5100m mountain, near Gar town, where is an excellent site for both infrared and submillimeter observations. Study with the long-term database of ground weather stations and archival satellite data has been performed. The site has enough relative height on the plateau and is accessible by car. The Shiquanhe town is 40 mins away by driving, and a recently opened airport with 40 mins driving, the site also has road excess, electricity, and optical fiber with fast internet. Preliminary measurement of the Precipitable Water Vapor is ~one quarter less than 0.5mm per year and the long term monitoring is under development. In addition, surrounding higher sites are also available and could be further developed if necessary. Ali provides unique northern sky coverage and together with the South Pole and the Atacama desert, future CMB observations will be able to cover the full sky from ground.

  18. An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration.

    PubMed

    Ulbricht, Catherine; Conquer, Julie; Flanagan, Kelly; Isaac, Richard; Rusie, Erica; Windsor, Regina C

    2013-03-01

    An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale. This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

  19. The ALI-ARMS Code for Modeling Atmospheric non-LTE Molecular Band Emissions: Current Status and Applications

    NASA Technical Reports Server (NTRS)

    Kutepov, A. A.; Feofilov, A. G.; Manuilova, R. O.; Yankovsky, V. A.; Rezac, L.; Pesnell, W. D.; Goldberg, R. A.

    2008-01-01

    The Accelerated Lambda Iteration (ALI) technique was developed in stellar astrophysics at the beginning of 1990s for solving the non-LTE radiative transfer problem in atomic lines and multiplets in stellar atmospheres. It was later successfully applied to modeling the non-LTE emissions and radiative cooling/heating in the vibrational-rotational bands of molecules in planetary atmospheres. Similar to the standard lambda iterations ALI operates with the matrices of minimal dimension. However, it provides higher convergence rate and stability due to removing from the iterating process the photons trapped in the optically thick line cores. In the current ALI-ARMS (ALI for Atmospheric Radiation and Molecular Spectra) code version additional acceleration of calculations is provided by utilizing the opacity distribution function (ODF) approach and "decoupling". The former allows replacing the band branches by single lines of special shape, whereas the latter treats non-linearity caused by strong near-resonant vibration-vibrational level coupling without additional linearizing the statistical equilibrium equations. Latest code application for the non-LTE diagnostics of the molecular band emissions of Earth's and Martian atmospheres as well as for the non-LTE IR cooling/heating calculations are discussed.

  20. Identification of Antifungal Substances of Lactobacillus sakei subsp. ALI033 and Antifungal Activity against Penicillium brevicompactum Strain FI02.

    PubMed

    Huh, Chang Ki; Hwang, Tae Yean

    2016-03-01

    This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear zones, suggesting that the antifungal substances produced by ALI033 were non-protein substances unaffected by protesases. Both, the control and catalase showed clear zones, suggesting that the antifungal metabolite was not H2O2. The molecular weights of the antifungal substances were ≤3,000 Da. The organic acid content of crude antifungal substances produced by L. sakei subsp. ALI033 showed high concentrations of lactic acid (502.47 mg/100 g). Therefore, these results suggest that antifungal substance produced by L. sakei subsp. ALI033 is most likely due to its ability in producing organic acid.

  1. Identification of Antifungal Substances of Lactobacillus sakei subsp. ALI033 and Antifungal Activity against Penicillium brevicompactum Strain FI02

    PubMed Central

    Huh, Chang Ki; Hwang, Tae Yean

    2016-01-01

    This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear zones, suggesting that the antifungal substances produced by ALI033 were non-protein substances unaffected by protesases. Both, the control and catalase showed clear zones, suggesting that the antifungal metabolite was not H2O2. The molecular weights of the antifungal substances were ≤3,000 Da. The organic acid content of crude antifungal substances produced by L. sakei subsp. ALI033 showed high concentrations of lactic acid (502.47 mg/100 g). Therefore, these results suggest that antifungal substance produced by L. sakei subsp. ALI033 is most likely due to its ability in producing organic acid. PMID:27069906

  2. An Approach to the Stories of Sabahattin Ali within the Context of Marxist Literary Aesthetics: The Conflict between Peasants and the Intelligentsia

    ERIC Educational Resources Information Center

    Yigit, Murat

    2016-01-01

    This study will try to read the stories of Sabahattin Ali, who has written various books in Turkish, within the context of Marxist literary aesthetics, assess the types and characters in the stories of Sabahattin Ali within that framework, and observe the social levels and the gaps between them based on the relationships between the two extreme…

  3. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-4-ol) ester of cy-clo-ali-phatic spiroketal. 721.9527 Section 721.9527 Protection of Environment...-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal. (a) Chemical substance and significant new uses...-piperidin-4-ol) ester of cycloaliphatic spiroketal (PMN No. P-91-1361) is subject to reporting under...

  4. Lithospheric mantle evolution in the Afro-Arabian domain: Insights from Bir Ali mantle xenoliths (Yemen)

    NASA Astrophysics Data System (ADS)

    Sgualdo, P.; Aviado, K.; Beccaluva, L.; Bianchini, G.; Blichert-Toft, J.; Bryce, J. G.; Graham, D. W.; Natali, C.; Siena, F.

    2015-05-01

    Detailed petrological and geochemical investigations of an extensive sampling of mantle xenoliths from the Neogene-Quaternary Bir Ali diatreme (southern Yemen) indicate that the underlying lithospheric mantle consists predominantly of medium- to fine-grained (often foliated) spinel-peridotites (85-90%) and spinel-pyroxenites (10-15%) showing thermobarometric estimates in the P-T range of 0.9-2.0 GPa and 900-1150 °C. Peridotites, including lherzolites, harzburgites and dunites delineate continuous chemical, modal and mineralogical variations compatible with large extractions of basic melts occurring since the late Proterozoic (~ 2 Ga, according to Lu-Hf model ages). Pyroxenites may represent intrusions of subalkaline basic melts interacting and equilibrated with the host peridotite. Subsequent metasomatism has led to modal changes, with evidence of reaction patches and clinopyroxene and spinel destabilization, as well as formation of new phases (glass, amphibole and feldspar). These changes are accompanied by enrichment of the most incompatible elements and isotopic compositions. 143Nd/144Nd ranges from 0.51419 to 0.51209 (εNd from + 30.3 to - 10.5), 176Hf/177Hf from 0.28459 to 0.28239 (εHf from + 64.4 to - 13.6), and 208Pb/204Pb from 36.85 to 41.56, thus extending from the depleted mantle (DM) towards the enriched OIB mantle (EM and HIMU) components. 3He/4He (R/RA) ratios vary from 7.2 to 7.9 with He concentrations co-varying with the most incompatible element enrichment, in parallel with metasomatic effects. These metasomatic events, particularly effective in harzburgites and dunites, are attributable to the variable interaction with alkaline basic melts related to the general extensional and rifting regime affecting the East Africa-Arabian domain during the Cenozoic. In this respect, Bir Ali mantle xenoliths resemble those occurring along the Arabian margins and the East Africa Rift system, similarly affected by alkaline metasomatism, whereas they are

  5. A Review of Ferdous al-Hekma fil-Tibb by Ali ibn Raban Tabari

    PubMed Central

    Ardalan, Mohammadreza; Khodadoust, Kazem; Mostafidi, Elmira

    2015-01-01

    T Ferdous al-Hekma (Paradise of Wisdom) is one of the oldest medical texts in the Islamic world written in Arabic in 850 AD by Ali ibn Raban Tabari. He was a Persian physician who moved from Tabaristan (Mazandaran province of modern day Iran) to Samarra during the reign of the Abbasid Caliph al-Mutawakkil (847-861 AD). We studied the book of Ferdous al-Hekma fil-Tibb, in an attempt to comprehend its general outlook on diseases of different organs, their classifications and the associated signs and symptoms. The book is one of the earliest medical pandects of the period of translation, adaptation and expansion of knowledge in the Islamic world during the 9th century AD. Tabari was mainly influenced by Hippocrates, Galen and Aristotle, as well as his contemporaries Johanna ibn Massavieh and Hunayn ibn Ishaq. The book is written in thirty chapters in a total number of 308 subtitles. In each part there is an introduction to the symptomatology, followed by organ specific diseases and therapeutic recommendations. Symptoms and physical signs of different diseases are vividly described in Ferdous al-Hekma, and some of them are even understandable for contemporary medical students. PMID:27350863

  6. Remembering Ali Alpar's Early Work, and: Three Types of Neutron Stars?

    NASA Astrophysics Data System (ADS)

    van den Heuvel, E. P. J.

    2011-09-01

    Some memories of Ali Alpar and his early work are presented, with particular emphasis on his work on the origin of milliscond pulsars. After this, arguments are summarized, indicating the existence of three categories of neutron stars, with two different formation mechanisms: (i) A low-mass category ( M~1.25 +/- 0.05 solar masses), characterized by low kick velocities. These neutron stars most probably formed by electron-capture collapse in degenerate O-Ne-Mg cores of stars of initial masses between ~8 and ~11 solar masses. (ii) An intermediate-mass category (M~1.40 +/- 0.10 solar masses), characterized by high kick velocities. These stars formed by the collapse of the iron cores of stars with initial masses probably between ~11 and ~19 solar masses. (iii) A category of massive neutron stars (M >= 1.70 solar masses), also characterized by high space velocities, and formed by the collapse of the iron cores, in this case of stars with intial masses >19 solar mases.

  7. In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat.

    PubMed

    Solomon, M C; Erasmus, N; Henkel, R R

    2014-05-01

    An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm parameters in terms of safety and efficacy in the management of male infertility. Forty-two male rats were divided into a control, low-dose (200 mg kg(-1) BW) and high-dose (800 mg kg(-1) BW) group (n = 14). Rats were force-fed for 14 days and then sacrificed. Total body and organ weights of the prostate, testes, epididymides, gastrocnemius muscle and the omentum were recorded. Moreover, testosterone concentration, sperm concentration, motility, velocity, vitality, acrosome reaction and mitochondrial membrane potential (MMP) were assessed. Whilst TA decreased BW by 5.7% (P = 0.0276) and omentum fat by 31.9% (P = 0.0496), no changes in organ weights were found for the prostate, testes and epididymides. Testosterone concentration increased by 30.2% (P = 0.0544). Muscle weight also increased, yet not significantly. Whilst sperm concentration, total and progressive motility and vitality increased significantly, MMP improved markedly (P = 0.0765) by 25.1%. Because no detrimental effect could be observed, TA appears safe for possible treatment of male infertility and ageing male problems.

  8. Effect of Eurycoma longifolia Jack (Tongkat ali) extract on human spermatozoa in vitro.

    PubMed

    Erasmus, N; Solomon, M C; Fortuin, K A; Henkel, R R

    2012-10-01

    Eurycoma longifolia (Tongkat ali; TA) is a Malaysian shrub used to treat various illnesses including male infertility. Considering that TA is used to improve male fertility and no report regarding its safety has been published, this study investigated the effects of TA extract on various sperm functions. Semen samples of 27 patients and 13 donors were divided into two groups, washed and swim-up spermatozoa, and incubated with different concentrations of TA (1, 10, 20, 100, 2000 μg ml(-1) ) for 1 h at 37 °C. A sample without addition of TA served as control. For washed spermatozoa, significant dose-dependent trends were found for vitality, total motility, acrosome reaction and reactive oxygen species-positive spermatozoa. However, these trends were only significant if the highest concentrations were included in the calculation. Contrary, the increase in the percentage of acrosome-reacted spermatozoa with increasing TA concentrations is very significant (P < 0.0001), and a significant difference (P = 0.0069) to the control could even be recorded at 20 μg TA per ml. For swim-up spermatozoa, no trend could be observed. Results indicate that the TA extract has no deleterious effects on sperm functions at therapeutically used concentrations (<2.5 μg ml(-1) ). However, at very high concentrations, TA may have harmful effects in vitro.

  9. Professor Mansour Ali Haseeb: Highlights from a pioneer of biomedical research, physician and scientist.

    PubMed

    Salih, Mustafa Abdalla M

    2013-01-01

    The article highlights the career of Professor Mansour Ali Haseeb (1910 - 1973; DKSM, Dip Bact, FRCPath, FRCP [Lond]), a pioneer worker in health, medical services, biomedical research and medical education in the Sudan. After his graduation from the Kitchener School of Medicine (renamed, Faculty of Medicine, University of Khartoum [U of K]) in 1934, he devoted his life for the development of laboratory medicine. He became the first Sudanese Director of Stack Medical Research Laboratories (1952 - 1962). He made valuable contributions by his services in the vaccine production and implementation programs, most notably in combating small pox, rabies and epidemic meningitis. In 1963 he became the first Sudanese Professor of Microbiology and Parasitology and served as the first Sudanese Dean of the Faculty of Medicine, U of K (1963-1969). He was an active loyal citizen in public life and served in various fields outside the medical profession. As Mayor of Omdurman, he was invited to visit Berlin in 1963 by Willy Brandt, Mayor of West Berlin (1957-1966) and Chancellor of the Federal Republic of Germany (1969 to 1974). Also as Mayor of Omdurman, he represented the City in welcoming Queen Elizabeth II during her visit to Sudan in February 1965. He also received State Medals from Egypt and Ethiopia. In 1973 he was appointed Chairman of the Sudan Medical Research Council, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO for his contribution in the advancement of health, research and medical services.

  10. Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus.

    PubMed

    Huang, Hsiu-Chen; Lee, Chung-Pei; Liu, Hui-Kang; Chang, Ming-Fu; Lai, Yu-Heng; Lee, Yu-Ching; Huang, Cheng

    2016-12-09

    Hepatitis delta virus (HDV) is a satellite virus of hepatitis B virus (HBV). HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), which is required for viral replication, and large HDAg (HDAg-L), which is essential for viral assembly. HDAg-L is identical to HDAg-S except that it bears a 19-amino acid extension at the C terminus. Both HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclear export signal at its C terminus. The nuclear export activity of HDAg-L is important for HDV particle formation. However, the mechanisms of HDAg-L-mediated nuclear export of HDV ribonucleoprotein are not clear. In this study, the host cellular RNA export complex TAP-Aly was found to form a complex with HDAg-L, but not with an export-defective HDAg-L mutant, in which Pro(205) was replaced by Ala. HDAg-L was found to colocalize with TAP and Aly in the nucleus. The C-terminal domain of HDAg-L was shown to directly interact with the N terminus of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP. In addition, small hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT-HDAg-L(198-210), containing the 10-amino acid TAT peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion. These data demonstrate that formation and release of HDV particles are mediated by TAP and Aly.

  11. Mapping forest height, foliage height profiles and disturbance characteristics with time series of gap-filled Landsat and ALI imagery

    NASA Astrophysics Data System (ADS)

    Helmer, E.; Ruzycki, T. S.; Wunderle, J. M.; Kwit, C.; Ewert, D. N.; Voggesser, S. M.; Brandeis, T. J.

    2011-12-01

    We mapped tropical dry forest height (RMSE = 0.9 m, R2 = 0.84, range 0.6-7 m) and foliage height profiles with a time series of gap-filled Landsat and Advanced Land Imager (ALI) imagery for the island of Eleuthera, The Bahamas. We also mapped disturbance type and age with decision tree classification of the image time series. Having mapped these variables in the context of studies of wintering habitat of an endangered Nearctic-Neotropical migrant bird, the Kirtland's Warbler (Dendroica kirtlandii), we then illustrated relationships between forest vertical structure, disturbance type and counts of forage species important to the Kirtland's Warbler. The ALI imagery and the Landsat time series were both critical to the result for forest height, which the strong relationship of forest height with disturbance type and age facilitated. Also unique to this study was that seven of the eight image time steps were cloud-gap-filled images: mosaics of the clear parts of several cloudy scenes, in which cloud gaps in a reference scene for each time step are filled with image data from alternate scenes. We created each cloud-cleared image, including a virtually seamless ALI image mosaic, with regression tree normalization of the image data that filled cloud gaps. We also illustrated how viewing time series imagery as red-green-blue composites of tasseled cap wetness (RGB wetness composites) aids reference data collection for classifying tropical forest disturbance type and age.

  12. 75 FR 2921 - In the Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE In the Matter of the Designation of Said Ali al-Shihri, Also Known as Abu-Sayyaf, Also Known as Abu-Sufyan al-Azidi, Also Known as Abu-Sayyaf al-Shihri, Also Known as Abu Sufian Kadhdhaab Matrook, Also Known as Sa'id Ali Jabir al-Khathim al-Shihri,...

  13. Effects of Rapid Thermal Annealing and Different Oxidants on the Properties of LaxAlyO Nanolaminate Films Deposited by Atomic Layer Deposition.

    PubMed

    Fei, Chenxi; Liu, Hongxia; Wang, Xing; Zhao, Lu; Zhao, Dongdong; Feng, Xingyao

    2017-12-01

    A comparative study of different sequences of two metal precursors [trimethylaluminum (TMA) and Tris(isopropylcyclopentadienyl) lanthanum (La((i)PrCp)3)] for atomic layer deposition (ALD) lanthanum aluminum oxide (LaxAlyO) films is carried out. The percentage compositions of C and N impurity of LaxAlyO films were investigated using in situ X-ray photoelectron spectroscopy (XPS). The effects of different oxidants on the physical and chemical properties and electrical characteristics of LaxAlyO films are studied before and after annealing. Preliminary testing results indicate that the impurity level of LaxAlyO films grown with different oxidants can be well controlled before and after annealing. Analysis indicates the rapid thermal annealing (RTA) and kinds of oxidants have significant effects on the equivalent oxide thickness (EOT), dielectric constant, electrical properties, and stability of LaxAlyO films. Additionally, the change of chemical bond types of rapid thermal annealing effects on the properties of LaxAlyO films are grown with different oxidants also investigated by XPS.

  14. Mineral mapping on the Chilean-Bolivian Altiplano using co-orbital ALI, ASTER and Hyperion imagery: Data dimensionality issues and solutions

    USGS Publications Warehouse

    Hubbard, B.E.; Crowley, J.K.

    2005-01-01

    Hyperspectral data coverage from the EO-1 Hyperion sensor was useful for calibrating Advanced Land Imager (ALI) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) images of a volcanic terrane area of the Chilean-Bolivian Altiplano. Following calibration, the ALI and ASTER datasets were co-registered and joined to produce a 13-channel reflectance cube spanning the Visible to Short Wave Infrared (0.4-2.4 ??m). Eigen analysis and comparison of the Hyperion data with the ALI + ASTER reflectance data, as well as mapping results using various ALI+ASTER data subsets, provided insights into the information dimensionality of all the data. In particular, high spectral resolution, low signal-to-noise Hyperion data were only marginally better for mineral mapping than the merged 13-channel, low spectral resolution, high signal-to-noise ALI + ASTER dataset. Neither the Hyperion nor the combined ALI + ASTER datasets had sufficient information dimensionality for mapping the diverse range of surface materials exposed on the Altiplano. However, it is possible to optimize the use of the multispectral data for mineral-mapping purposes by careful data subsetting, and by employing other appropriate image-processing strategies.

  15. Characterizing magnetospheric electrons from ALIS observations of discrete auroral arcs and quasi-stationary modeling of auroral acceleration

    NASA Astrophysics Data System (ADS)

    Lamy, H.; Simon, C.; Echim, M.; de Keyser, J. M.; Gustavsson, B.; Sergienko, T.; Sandahl, I.; Brandstrom, U.

    2010-12-01

    From a series of images obtained simultaneously with the CCD cameras of the ALIS (Auroral Large Imaging System) network located in Scandinavia, three-dimensional (3D) large-scale structures of discrete auroral arcs can be retrieved in several filters with tomography-like techniques. In particular, the 3D reconstructed volume emission rates at 4278 Å can be used to derive the energy spectra of precipitating magnetospheric electrons in 2D, along and across the arc, with a spatial resolution of approximately 3 km. These spectra directly provide E0, the characteristic energy and ɛm, the total flux energy of precipitating electrons. The latter can be used together with a kinetic modelling of adiabatic motion of particles (Lundin & Sandahl, 1978) and assuming a Maxwellian distribution for magnetospheric electrons, to derive ΔΦ, the field-aligned potential difference between the ionosphere and magnetosphere. The next step is to use a quasi-static magnetosphere-ionosphere coupling model based on the current continuity in the ionosphere (Echim et al, 2007) and the model of tangential discontinuity generators (Roth et al 1993) to determine densities (ne) and temperatures (Te) of the magnetospheric electrons. The model is run iteratively for typical values of magnetospheric ne and Te that are adjusted until ΔΦ provided by the model is in agreement with the one determined from ALIS observations. This technique allows to obtain information about the properties of the generator of the auroral arc, from ground-based observations and quasi-stationary modeling. Future conjugated observations between ALIS and a spacecraft crossing the same magnetic field lines above the acceleration region could be used to validate this novel technique.

  16. AliBiMotif: integrating alignment and biclustering to unravel transcription factor binding sites in DNA sequences.

    PubMed

    Gonçalves, Joana P; Moreau, Yves; Madeira, Sara C

    2012-01-01

    Transcription Factors (TFs) control transcription by binding to specific sites in the promoter regions of the target genes, which can be modelled by structured motifs. In this paper we propose AliBiMotif, a method combining sequence alignment and a biclustering approach based on efficient string matching techniques using suffix trees to unravel approximately conserved sets of blocks (structured motifs) while straightforwardly disregarding non-conserved stretches in-between. The ability to ignore the width of non-conserved regions is a major advantage of the proposed method over other motif finders, as the lengths of the binding sites are usually easier to estimate than the separating distances.

  17. The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.

    PubMed

    Tian, Xiaochen; Devi-Rao, Gayathri; Golovanov, Alexander P; Sandri-Goldin, Rozanne M

    2013-07-01

    Herpes simplex virus 1 (HSV-1) protein ICP27 enables viral mRNA export by accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through the nuclear pore complex. ICP27 binds viral mRNAs and interacts with TAP/NXF, providing a link to the cellular mRNA export pathway. ICP27 also interacts with the mRNA export adaptor protein Aly/REF, which binds cellular mRNAs and also interacts with TAP/NXF. Studies using small interfering RNA (siRNA) knockdown indicated that Aly/REF is not required for cellular mRNA export, and similar knockdown studies during HSV-1 infection led us to conclude that Aly/REF may be dispensable for viral RNA export. Recently, the structural basis of the interaction of ICP27 with Aly/REF was elucidated at atomic resolution, and it was shown that three ICP27 residues, W105, R107, and L108, interface with the RNA recognition motif (RRM) domain of Aly/REF. Here, to determine the role the interaction of ICP27 and Aly/REF plays during infection, these residues were mutated to alanine, and a recombinant virus, WRL-A, was constructed. Virus production was reduced about 10-fold during WRL-A infection, and export of ICP27 protein and most viral mRNAs was less efficient. We conclude that interaction of ICP27 with Aly/REF contributes to efficient viral mRNA export.

  18. Zonation of flood production potential in Kabutar Ali Chai watershed using SCS model

    NASA Astrophysics Data System (ADS)

    Jananeh, Keristineh

    2015-04-01

    Kabutar Ali Chai watershed is located on the southern hillsides of Mishow mountains, 75 km northwest of Tabriz, NW Iran. This watershed is confined to 1390 and 3230 m elevation levels, where the general dip is from north to south. The watershed area is 67.46 km2 and the length of the main stream is about 24.5 km. This is one of the flood basins in the region and considering the availability of precipitation data for the 20 year interval and the possibility of flood occurrence threatening the downstream villages, the flood production investigations in order to prioritize the sub-basins regarding their flood-potential were carried out using the SCS method. In this regard, the watershed area was divided into 4 sections based on physiographic and topographic characteristics and the existing stream network: A1 (the southern and the low-height end of the watershed), A2 (the mid-western half), A3 (the mid-eastern half) and A4 (the northern and highest part). The precipitation data for 20 year interval were gathered from the nearby weather stations of Tabriz, Sahand, Marand and Sharafkhaneh based on which, the average annual precipitation is about 294 mm, with the highest amounts of 415 to 450 mm in A4 sub-basin and the lowest value of 253 mm in the southern A1 sub-basin. According to the time of concentration estimates based on the stream lengths and the elevation differences, this parameter is highest in A1 sub-basin with the rate of 1.64 h and lowest at A3 sub-basin with the rate of 0.35 h. This parameter has negative correlation with the flood production potential. The runoff height is estimated using the SCS method. In order to determine the CN curve Number, the maps of hydrologic groups of soil, land use and vegetation were prepared and combined with each other and then, by taking into account the area of each homogeneous unit, the CN number was calculated for the watershed and the related CN map was prepared. The peak discharge of the hydrologic units across the

  19. Equations of state of anhydrous AlF3 and AlI3: Modeling of extreme condition halide chemistry

    NASA Astrophysics Data System (ADS)

    Stavrou, Elissaios; Zaug, Joseph M.; Bastea, Sorin; Crowhurst, Jonathan C.; Goncharov, Alexander F.; Radousky, Harry B.; Armstrong, Michael R.; Roberts, Sarah K.; Plaue, Jonathan W.

    2015-06-01

    Pressure dependent angle-dispersive x-ray powder diffraction measurements of alpha-phase aluminum trifluoride (α-AlF3) and separately, aluminum triiodide (AlI3) were conducted using a diamond-anvil cell. Results at 295 K extend to 50 GPa. The equations of state of AlF3 and AlI3 were determined through refinements of collected x-ray diffraction patterns. The respective bulk moduli and corresponding pressure derivatives are reported for multiple orders of the Birch-Murnaghan (B-M), finite-strain (F-f), and higher pressure finite-strain (G-g) EOS analysis models. Aluminum trifluoride exhibits an apparent isostructural phase transition at approximately 12 GPa. Aluminum triiodide also undergoes a second-order atomic rearrangement: applied stress transformed a monoclinically distorted face centered cubic (fcc) structure into a standard fcc structural arrangement of iodine atoms. Results from semi-empirical thermochemical computations of energetic materials formulated with fluorine containing reactants were obtained with the aim of predicting the yield of halogenated products.

  20. Synthesis of Multispectral Bands from Hyperspectral Data: Validation Based on Images Acquired by AVIRIS, Hyperion, ALI, and ETM+

    NASA Technical Reports Server (NTRS)

    Blonski, Slawomir; Glasser, Gerald; Russell, Jeffrey; Ryan, Robert; Terrie, Greg; Zanoni, Vicki

    2003-01-01

    Spectral band synthesis is a key step in the process of creating a simulated multispectral image from hyperspectral data. In this step, narrow hyperspectral bands are combined into broader multispectral bands. Such an approach has been used quite often, but to the best of our knowledge accuracy of the band synthesis simulations has not been evaluated thus far. Therefore, the main goal of this paper is to provide validation of the spectral band synthesis algorithm used in the ART software. The next section contains a description of the algorithm and an example of its application. Using spectral responses of AVIRIS, Hyperion, ALI, and ETM+, the following section shows how the synthesized spectral bands compare with actual bands, and it presents an evaluation of the simulation accuracy based on results of MODTRAN modeling. In the final sections of the paper, simulated images are compared with data acquired by actual satellite sensors. First, a Landsat 7 ETM+ image is simulated using an AVIRIS hyperspectral data cube. Then, two datasets collected with the Hyperion instrument from the EO-1 satellite are used to simulate multispectral images from the ALI and ETM+ sensors.

  1. Caractérisation de jonctions ultra-minces réalisées par dopage laser

    NASA Astrophysics Data System (ADS)

    Kerrien, G.; Sarnet, T.; Débarre, D.; Hernandez, M.; Zahorski, D.; Venturini, J.; Laviron, C.; Semeria, M. N.; Boulmer, J.

    2003-06-01

    Cette étude concerne les techniques de recuit laser (LTP) et de dopage laser direct (GILD) de jonctions ultra-minces, nécessaires à la fabrication des composants microélectroniques du futur (générations CMOS sub 0,1 μm). Des jonctions de 20 à 80 nm sont réalisées à l'aide d'un laser à excimères. Le procédé est suivi en temps réel grâce à l'analyse de la réflectivité transitoire à 675 nm. L'évolution de l'activation des dopants est ensuite caractérisée par spectroscopie IR (FTIR). Les résultats obtenus permettent de caractériser les jonctions en termes d'épaisseur dopées, concentration et résistivité. Une comparaison avec des caractérisations classiques (mesures électriques de résistivité, profils SIMS) permet de valider ces mesures et de mettre en évidence l'intérêt des techniques optiques pour la caractérisation in-situ et ex-situ des couches minces dopées réalisées par laser.

  2. [Pathology of adaptation according to Sami-Ali and index of conformity to the Rorschach test in ulcerative rectocolitis].

    PubMed

    Porcelli, P; Zaka, S; Tarantino, S; Sisto, G

    1992-01-01

    According to Sami-Ali's theoretical model the psychosomatic personality is characterised by an adaptation pathology whose main elements are the repression of imaginative thought and conformity to socio-cultural standards. This study examines adaptation pathology using the Rorschach test. The Authors have formulated a conformity index by relating kinestheses (M) and banal perceptions (BAN). The study was carried out on a sample of 41 patients suffering from ulcerous rectocolitis comprising 24 males and 17 women with a mean age of 32 years. As expected in the hypothesis 97.6% of the sample showed M values below the norm, and 68.3% had Ban values higher than normal, whereas the conformity index was positive and tendentially positive in 65.9% of cases. These findings confirm Sami-Ali's theory. Subjects with ulcerous rectocolitis form part of the adaptation pathology which characterised the psychosomatic personality, with an inverse proportionality between imaginative activity (kinesthesia below normal) and conformism (banal perceptions above the norm).

  3. Equations of state of anhydrous AlF3 and AlI3: Modeling of extreme condition halide chemistry.

    PubMed

    Stavrou, Elissaios; Zaug, Joseph M; Bastea, Sorin; Crowhurst, Jonathan C; Goncharov, Alexander F; Radousky, Harry B; Armstrong, Michael R; Roberts, Sarah K; Plaue, Jonathan W

    2015-06-07

    Pressure dependent angle-dispersive x-ray powder diffraction measurements of alpha-phase aluminum trifluoride (α-AlF3) and separately, aluminum triiodide (AlI3) were conducted using a diamond-anvil cell. Results at 295 K extend to 50 GPa. The equations of state of AlF3 and AlI3 were determined through refinements of collected x-ray diffraction patterns. The respective bulk moduli and corresponding pressure derivatives are reported for multiple orders of the Birch-Murnaghan (B-M), finite-strain (F-f), and higher pressure finite-strain (G-g) EOS analysis models. Aluminum trifluoride exhibits an apparent isostructural phase transition at approximately 12 GPa. Aluminum triiodide also undergoes a second-order atomic rearrangement: applied stress transformed a monoclinically distorted face centered cubic (fcc) structure into a standard fcc structural arrangement of iodine atoms. Results from semi-empirical thermochemical computations of energetic materials formulated with fluorine containing reactants were obtained with the aim of predicting the yield of halogenated products.

  4. Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2 ▿

    PubMed Central

    Hatakeyama, Riko; Kamiya, Masao; Takahara, Terunao; Maeda, Tatsuya

    2010-01-01

    Endocytosis of nutrient transporters is stimulated under various conditions, such as elevated nutrient availability. In Saccharomyces cerevisiae, endocytosis is triggered by ubiquitination of transporters catalyzed by the E3 ubiquitin ligase Rsp5. However, how the ubiquitination is accelerated under certain conditions remains obscure. Here we demonstrate that closely related proteins Aly2/Art3 and Aly1/Art6, which are poorly characterized members of the arrestin-like protein family, mediate endocytosis of the aspartic acid/glutamic acid transporter Dip5. In aly2Δ cells, Dip5 is stabilized at the plasma membrane and is not endocytosed efficiently. Efficient ubiquitination of Dip5 is dependent on Aly2. aly1Δ cells also show deficiency in Dip5 endocytosis, although less remarkably than aly2Δ cells. Aly2 physically interacts in vivo with Rsp5 at its PY motif and also with Dip5, thus serving as an adaptor linking Rsp5 with Dip5 to achieve Dip5 ubiquitination. Importantly, the interaction between Aly2 and Dip5 is accelerated in response to elevated aspartic acid availability. This result indicates that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2. PMID:20956561

  5. New insights into the structure of Om Ali-Thelepte basin, central Tunisia, inferred from gravity data: Hydrogeological implications

    NASA Astrophysics Data System (ADS)

    Harchi, Mongi; Gabtni, Hakim; El Mejri, Hatem; Dassi, Lassaad; Mammou, Abdallah Ben

    2016-08-01

    This work presents new results from gravity data analyses and interpretation within the Om Ali-Thelepte (OAT) basin, central Tunisia. It focuses on the hydrogeological implication, using several qualitative and quantitative techniques such as horizontal gradient, upward continuation and Euler deconvolution on boreholes log data, seismic reflection data and electrical conductivity measurements. The structures highlighted using the filtering techniques suggest that the Miocene aquifer of OAT basin is cut by four major fault systems that trend E-W, NE-SW, NW-SE and NNE-SSW. In addition, a NW-SE gravity model established shows the geometry of the Miocene sandstone reservoir and the Upper Cretaceous limestone rocks. Moreover, the superimposition of the electrical conductivity and the structural maps indicates that the low conductivity values of sampled water from boreholes are located around main faults.

  6. Probing the structures of gold-aluminum alloy clusters AuxAly(-): a joint experimental and theoretical study.

    PubMed

    Khetrapal, Navneet Singh; Jian, Tian; Pal, Rhitankar; Lopez, Gary V; Pande, Seema; Wang, Lai-Sheng; Zeng, Xiao Cheng

    2016-05-05

    Besides the size and structure, compositions can also dramatically affect the properties of alloy nanoclusters. Due to the added degrees of freedom, determination of the global minimum structures for multi-component nanoclusters poses even greater challenges, both experimentally and theoretically. Here we report a systematic and joint experimental/theoretical study of a series of gold-aluminum alloy clusters, AuxAly(-) (x + y = 7,8), with various compositions (x = 1-3; y = 4-7). Well-resolved photoelectron spectra have been obtained for these clusters at different photon energies. Basin-hopping global searches, coupled with density functional theory calculations, are used to identify low-lying structures of the bimetallic clusters. By comparing computed electronic densities of states of the low-lying isomers with the experimental photoelectron spectra, the global minima are determined. It is found that for y ≥ 6 there is a strong tendency to form the magic-number square bi-pyramid motif of Al6(-) in the AuxAly(-) clusters, suggesting that the Al-Al interaction dominates the Au-Au interaction in the mixed clusters. A closely related trend is that for x > 1, the gold atoms tend to be separated by Al atoms unless only the magic-number Al6(-) square bi-pyramid motif is present, suggesting that in the small-sized mixed clusters, Al and Au components do not completely mix with one another. Overall, the Al component appears to play a more dominant role due to the high robustness of the magic-number Al6(-) square bi-pyramid motif, whereas the Au component tends to be either "adsorbed" onto the Al6(-) square bi-pyramid motif if y ≥ 6, or stays away from one another if x < y < 6.

  7. San Antonio v. Rodriguez. Analysis and Projection.

    ERIC Educational Resources Information Center

    McGhehey, M. A.

    In this report, the author analyzes the recent United States Supreme Court decision, compares it with the preceding California case, Serrano vs Priest, and predicts future changes in State school finance systems as a result of this case. The author traces the Court's reasoning for finding that there was no violation of the Equal Protection Clause…

  8. For the relief of Adrian Rodriguez.

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-02-03

    02/20/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism?

    PubMed

    Tambi, M I B M; Imran, M K; Henkel, R R

    2012-05-01

    In most countries, millions of people are relying on herbal medicines as remedy for numerous ailments. In South-East Asia, Eurycoma longifolia Jack, also known as 'Malaysian ginseng' or Tongkat ali, is used to combat stress and disease and to improve physical strength. Moreover, the compounds of the roots of this plant are reported to have aphrodisiac and testosterone enhancing effects in the rat. Considering that human studies are not available, 76 of 320 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of a standardised water-soluble extract of Tongkat ali for 1 month. The Ageing Males' Symptoms (AMS) according to the standardised rating scale and the serum testosterone concentration were taken. Results show that treatment of LOH patients with this Tongkat ali extract significantly (P < 0.0001) improved the AMS score as well as the serum testosterone concentration. While before treatment only 10.5% of the patients did not show any complaint according to the AMS scale and 35.5% had normal testosterone levels, after the completed treatment 71.7% and 90.8% of the patients showed normal values, respectively. Thus, Tongkat ali extract appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism.

  10. SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling

    PubMed Central

    Bai, Xiaozhi; Fan, Lei; He, Ting; Jia, Wenbin; Yang, Longlong; Zhang, Jun; Liu, Yang; Shi, Jihong; Su, Linlin; Hu, Dahai

    2015-01-01

    Silent information regulator type-1 (SIRT1) has been reported to be involved in the cardiopulmonary protection. However, its role in the pathogenesis of burn-induced remote acute lung injury (ALI) is currently unknown. The present study aims to investigate the role of SIRT1 in burn-induced remote ALI and the involved signaling pathway. We observed that SIRT1 expression in rat lung tissue after burn injury appeared an increasing trend after a short period of suppression. The upregulation of SIRT1 stimulated by resveratrol exhibited remission of histopathologic changes, reduction of cell apoptosis, and downregulation of pro-inflammatory cytokines in rat pulmonary tissues suffering from severe burn. We next used primary pulmonary microvascular endothelial cells (PMVECs) challenged by burn serum (BS) to simulate in vivo rat lung tissue after burn injury, and found that BS significantly suppressed SIRT1 expression, increased cell apoptosis, and activated p38 MAPK signaling. The use of resveratrol reversed these effects, while knockdown of SIRT1 by shRNA further augmented BS-induced increase of cell apoptosis and activation of p38 MAPK. Taken together, these results indicate that SIRT1 might protect lung tissue against burn-induced remote ALI by attenuating PMVEC apoptosis via p38 MAPK signaling, suggesting its potential therapeutic effects on the treatment of ALI. PMID:25992481

  11. Comparative Analysis of EO-1 ALI and Hyperion, and Landsat ETM+ Data for Mapping Forest Crown Closure and Leaf Area Index

    PubMed Central

    Pu, Ruiliang; Gong, Peng; Yu, Qian

    2008-01-01

    In this study, a comparative analysis of capabilities of three sensors for mapping forest crown closure (CC) and leaf area index (LAI) was conducted. The three sensors are Hyperspectral Imager (Hyperion) and Advanced Land Imager (ALI) onboard EO-1 satellite and Landsat-7 Enhanced Thematic Mapper Plus (ETM+). A total of 38 mixed coniferous forest CC and 38 LAI measurements were collected at Blodgett Forest Research Station, University of California at Berkeley, USA. The analysis method consists of (1) extracting spectral vegetation indices (VIs), spectral texture information and maximum noise fractions (MNFs), (2) establishing multivariate prediction models, (3) predicting and mapping pixel-based CC and LAI values, and (4) validating the mapped CC and LAI results with field validated photo-interpreted CC and LAI values. The experimental results indicate that the Hyperion data are the most effective for mapping forest CC and LAI (CC mapped accuracy (MA) = 76.0%, LAI MA = 74.7%), followed by ALI data (CC MA = 74.5%, LAI MA = 70.7%), with ETM+ data results being least effective (CC MA = 71.1%, LAI MA = 63.4%). This analysis demonstrates that the Hyperion sensor outperforms the other two sensors: ALI and ETM+. This is because of its high spectral resolution with rich subtle spectral information, of its short-wave infrared data for constructing optimal VIs that are slightly affected by the atmosphere, and of its more available MNFs than the other two sensors to be selected for establishing prediction models. Compared to ETM+ data, ALI data are better for mapping forest CC and LAI due to ALI data with more bands and higher signal-to-noise ratios than those of ETM+ data. PMID:27879906

  12. Cross-calibration of MODIS with ETM+ and ALI sensors for long-term monitoring of land surface processes

    USGS Publications Warehouse

    Meyer, D.; Chander, G.

    2006-01-01

    Increasingly, data from multiple sensors are used to gain a more complete understanding of land surface processes at a variety of scales. Although higher-level products (e.g., vegetation cover, albedo, surface temperature) derived from different sensors can be validated independently, the degree to which these sensors and their products can be compared to one another is vastly improved if their relative spectroradiometric responses are known. Most often, sensors are directly calibrated to diffuse solar irradiation or vicariously to ground targets. However, space-based targets are not traceable to metrological standards, and vicarious calibrations are expensive and provide a poor sampling of a sensor's full dynamic range. Crosscalibration of two sensors can augment these methods if certain conditions can be met: (1) the spectral responses are similar, (2) the observations are reasonably concurrent (similar atmospheric & solar illumination conditions), (3) errors due to misregistrations of inhomogeneous surfaces can be minimized (including scale differences), and (4) the viewing geometry is similar (or, some reasonable knowledge of surface bi-directional reflectance distribution functions is available). This study explores the impacts of cross-calibrating sensors when such conditions are met to some degree but not perfectly. In order to constrain the range of conditions at some level, the analysis is limited to sensors where cross-calibration studies have been conducted (Enhanced Thematic Mapper Plus (ETM+) on Landsat-7 (L7), Advance Land Imager (ALI) and Hyperion on Earth Observer-1 (EO-1)) and including systems having somewhat dissimilar geometry, spatial resolution & spectral response characteristics but are still part of the so-called "A.M. constellation" (Moderate Resolution Imaging Spectrometer (MODIS) aboard the Terra platform). Measures for spectral response differences and methods for cross calibrating such sensors are provided in this study. These

  13. Synthesis of Multispectral Bands from Hyperspectral Data: Validation Based on Images Acquired by AVIRIS, Hyperion, ALI, and ETM+

    NASA Technical Reports Server (NTRS)

    Blonksi, Slawomir; Gasser, Gerald; Russell, Jeffrey; Ryan, Robert; Terrie, Greg; Zanoni, Vicki

    2001-01-01

    Multispectral data requirements for Earth science applications are not always studied rigorously studied before a new remote sensing system is designed. A study of the spatial resolution, spectral bandpasses, and radiometric sensitivity requirements of real-world applications would focus the design onto providing maximum benefits to the end-user community. To support systematic studies of multispectral data requirements, the Applications Research Toolbox (ART) has been developed at NASA's Stennis Space Center. The ART software allows users to create and assess simulated datasets while varying a wide range of system parameters. The simulations are based on data acquired by existing multispectral and hyperspectral instruments. The produced datasets can be further evaluated for specific end-user applications. Spectral synthesis of multispectral images from hyperspectral data is a key part of the ART software. In this process, hyperspectral image cubes are transformed into multispectral imagery without changes in spatial sampling and resolution. The transformation algorithm takes into account spectral responses of both the synthesized, broad, multispectral bands and the utilized, narrow, hyperspectral bands. To validate the spectral synthesis algorithm, simulated multispectral images are compared with images collected near-coincidentally by the Landsat 7 ETM+ and the EO-1 ALI instruments. Hyperspectral images acquired with the airborne AVIRIS instrument and with the Hyperion instrument onboard the EO-1 satellite were used as input data to the presented simulations.

  14. Noise disturbance caused by outdoor activities--a simulated-environment study for Ali Sami Yen Stadium, İstanbul.

    PubMed

    Dal, Zeynep; Akdağ, Neşe Yüğrük

    2011-03-01

    Negative effects of noise on individuals, the inevitable result of urbanization, have become a significant urban problem in our day. Introduction of an approach to the noise problem on an urban-planning scale lightens the burden of measures required to be taken against noise at the stages of regional and developmental planning. Stadiums, which should be also evaluated from the point of noise problem when planning decisions are made on the urban planning scale, may cause very serious problems differing depending on the region they are located in. In this article, various dimensions of the noise problem caused by stadiums have been exemplified by making an assessment on Ali Sami Yen football stadium located in Mecidiyeköy district which is among important residential and commercial centres of İstanbul or Turkey. When the simulation results obtained for ordinary days and match days are evaluated, it has been found out that the people living in the area are exposed to noise levels substantially exceeding the acceptable values. Results of the survey conducted in the area have clearly revealed the existence of noise problem, too.

  15. Tongkat Ali as a potential herbal supplement for physically active male and female seniors--a pilot study.

    PubMed

    Henkel, Ralf R; Wang, Ruxiang; Bassett, Susan H; Chen, Tao; Liu, Na; Zhu, Ying; Tambi, Mohd Ismail

    2014-04-01

    Tongkat Ali (Eurycoma longifolia; TA) is known to increase testosterone levels and alleviate aging males' symptoms. This study aimed at investigating TA as an ergogenic supplement for elderly people. Thirteen physically active male and 12 physically active female seniors (57-72 years) were supplemented with 400-mg TA extract daily for 5 weeks. Standard hematological parameters were taken. In addition, the concentrations of total and free testosterone, dihydroepiandrosterone, cortisol, insulin-like growth factor-1, and sex hormone-binding globulin were analyzed. As additional biochemical parameters, blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage, respectively, as well as the muscle strength by a simple handgrip test were determined. After treatment, hemoglobin, testosterone, and dihydroepiandrosterone concentrations, and the ratio of total testosterone/cortisol and muscle force remained significantly lower in female seniors than in male seniors. Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors. Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women. The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations. The study affirms the ergogenic benefit of TA through enhanced muscle strength.

  16. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack).

    PubMed

    Li, Ching-Hao; Liao, Jiunn-Wang; Liao, Po-Lin; Huang, Wei-Kuang; Tse, Ling-Shan; Lin, Cheng-Hui; Kang, Jaw-Jou; Cheng, Yu-Wen

    2013-01-01

    Tongkat Ali (Eurycoma longifolia) is an indigenous traditional herb in Southern Asia. Its powdered root has been processed to produce health supplements, but no detailed toxicology report is available. In this study, neither mutagenicity nor clastogenicity was noted, and acute oral LD50 was more than 6 g/kg b.w. After 4-week subacute and 13-week subchronic exposure paradigms (0, 0.6, 1.2, and 2 g/kg b.w./day), adverse effects attributable to test compound were not observed with respect to body weight, hematology, serum biochemistry, urinalysis, macropathology, or histopathology. However, the treatment significantly reduced prothrombin time, partial thromboplastin time, blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphate kinase, lactate dehydrogenase, and cholesterol levels, especially in males (P < 0.05). These changes were judged as pharmacological effects, and they are beneficial to health. The calculated acceptable daily intake (ADI) was up to 1.2 g/adult/day. This information will be useful for product development and safety management.

  17. Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats.

    PubMed

    Ang, H H; Cheang, H S; Yusof, A P

    2000-01-01

    We studied the effects of Eurycoma longifolia Jack, commonly known as Tongkat Ali in Malaysia, on the initiation of sexual performance and the weights of sexual accessories in inexperienced castrated male rats. The doses of 200, 400 and 800 mg/kg body weight, which were extracted from E. longifolia Jack, were orally administered to the rats twice daily for 10 days prior to the tests and continued throughout the test period. Testosterone was used as a positive control after injecting 15 mg/kg daily subcutaneously for 32 days. Results showed that E. longifolia Jack produced a dose-dependent increase in sexual performance of the treated animals, but the E. longifolia Jack groups showed lower sexual performance in mounting, intromission and ejaculation than the testosterone group. Further results also showed that E. longifolia Jack promoted the growth of both ventral prostate and seminal vesicles as compared with the control, but the growth of sexual accessories at 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia Jack was less than that of testosterone treated group. The present study therefore gives further evidence of the folkuse of E. longifolia as an aphrodisiac.

  18. Alis, A State-of-the-Art Optical Observation Network for the Exploration of Polar Atmospheric Processes

    NASA Astrophysics Data System (ADS)

    Aso, T.; Steen, Å.; Brändström, U.; Gustavsson, B.; Urashima, A.; Ejiri, M.

    An optical group at the Swedish Institute of Space Physics in Kiruna, Sweden has been developing the ALIS (Auroral Large Imaging System) multi-station optical observing network which makes it possible to obtain composite monochromatic 2-D images over a fairly wide field-of-view (FOV), and more interestingly, a CT (Computed Tomography) image set for the retrieval of 3-D structure of aurora by adjusting vergence angles of cameras to a common volume. National Institute of Polar Research, Japan is collaborating in observation and analysis. At the moment, the network has 6 stations separated from each other by about 50 km.Each station houses a monochromatic CCD (Charge Coupled Device) imaging system mounted on the steerable azimuth/elevation drive along with a house keeping unit and supervising computer linked to the control center via a telephone line. Altitude profiles of luminosity for stable arc and aurora vortex at 557.7nm and recently at 427.8nm are analysed by the algebraic reconstruction technique and compared with sophisticated numerical modelling of auroral emission rate. Conjunctions with satellites and radars are now intensively explored towards comprehensive understanding of the formation and electrodynamics of aurora. Imaging of polar stratospheric clouds is also attempted in relation to arctic environmental studies

  19. Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats

    PubMed Central

    Yu, Jianbo; Wang, Ying; Li, Zhen; Dong, Shuan; Wang, Dan; Gong, Lirong; Shi, Jia; Zhang, Yuan; Liu, Daquan; Mu, Rui

    2016-01-01

    Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common and important oxidative stress in the lung. Mitochondrial fusion responds to the normal morphology and function of cells and is finely regulated by mitochondrial fusion proteins, such as mitofusin-1 protein (Mfn1), mitofusin-2 protein (Mfn2) and optical atrophy 1 (OPA1). Additionally, Mfn1 has been identified as the most important protein in mitochondrial fusion. Heme oxygenase-1 (HO-1) is a stress-inducible protein that plays a critical role in protecting against oxidative stress. However, whether the protection of HO-1 is related to mitochondrial fusion is still a question. Thus, our in vitro and in vivo experiments aimed to identify the relationship between HO-1 and Mfn1. Here, we used Hemin and ZnPP-IX as treatments in an in vivo experiment. Then, HO-1 and Mfn1 were measured using RT-PCR and Western blotting. Supernatants were analyzed for MDA, SOD, and ROS. Our results implied that HO-1 upregulation suppressed oxidative stress induced by LPS, and the possible mechanism could be associated with Mfn1 and the PI3K/Akt pathway. PMID:27830717

  20. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack)

    PubMed Central

    Liao, Jiunn-Wang; Liao, Po-Lin; Huang, Wei-Kuang; Tse, Ling-Shan; Lin, Cheng-Hui; Kang, Jaw-Jou; Cheng, Yu-Wen

    2013-01-01

    Tongkat Ali (Eurycoma longifolia) is an indigenous traditional herb in Southern Asia. Its powdered root has been processed to produce health supplements, but no detailed toxicology report is available. In this study, neither mutagenicity nor clastogenicity was noted, and acute oral LD50 was more than 6 g/kg b.w. After 4-week subacute and 13-week subchronic exposure paradigms (0, 0.6, 1.2, and 2 g/kg b.w./day), adverse effects attributable to test compound were not observed with respect to body weight, hematology, serum biochemistry, urinalysis, macropathology, or histopathology. However, the treatment significantly reduced prothrombin time, partial thromboplastin time, blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphate kinase, lactate dehydrogenase, and cholesterol levels, especially in males (P < 0.05). These changes were judged as pharmacological effects, and they are beneficial to health. The calculated acceptable daily intake (ADI) was up to 1.2 g/adult/day. This information will be useful for product development and safety management. PMID:24062779

  1. Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

    PubMed Central

    Poulsen, Lisbeth R.; Hanisch, Susanne; Meffert, Katharina; Buch-Pedersen, Morten J.; Jakobsen, Mia K.; Pomorski, Thomas Günther; Palmgren, Michael G.

    2010-01-01

    Members of the P4 subfamily of P-type ATPases are believed to catalyze flipping of phospholipids across cellular membranes, in this way contributing to vesicle biogenesis in the secretory and endocytic pathways. P4-ATPases form heteromeric complexes with Cdc50-like proteins, and it has been suggested that these act as β-subunits in the P4-ATPase transport machinery. In this work, we investigated the role of Cdc50-like β-subunits of P4-ATPases for targeting and function of P4-ATPase catalytic α-subunits. We show that the Arabidopsis P4-ATPases ALA2 and ALA3 gain functionality when coexpressed with any of three different ALIS Cdc50-like β-subunits. However, the final cellular destination of P4-ATPases as well as their lipid substrate specificity are independent of the nature of the ALIS β-subunit they were allowed to interact with. PMID:20053675

  2. Investigation on the neutral and anionic BxAlyH2 (x + y = 7, 8, 9) clusters using density functional theory combined with photoelectron spectroscopy.

    PubMed

    Ding, Li-Ping; Shao, Peng; Lu, Cheng; Zhang, Fang-Hui; Ding, Lei; Yuan, Tao Li

    2016-08-17

    The structure and bonding nature of neutral and negatively charged BxAlyH2 (x + y = 7, 8, 9) clusters are investigated with the aid of previously published experimental photoelectron spectra combined with the present density functional theory calculations. The comparison between the experimental photoelectron spectra and theoretical simulated spectra helps to identify the ground state structures. The accuracy of the obtained ground state structures is further verified by calculating their adiabatic electron affinities and vertical detachment energies and comparing them against available experimental data. The results show that the structures of BxAlyH2 transform from three-dimensional to planar structures as the number of boron atoms increases. Moreover, boron atoms tend to bind together forming Bn units. The hydrogen atoms prefer to bind with boron atoms rather than aluminum atoms. The analyses of the molecular orbital on the ground state structures further support the abovementioned results.

  3. Implementation of the final geometry of the V0A detector for the ALICE experiment in the simulator program AliRoot

    SciTech Connect

    Valencia, L.

    2008-07-02

    The V0A trigger detector of the ALICE experiment is a scintillator hodoscope of 32 channels that has been designed and constructed by the Mexican groups at the Instituto de Fisica de la UNAM and the CINVESTAV.In this work, the final geometry of the constructed detector and its support frame have been implemented using the geometrical modeler of the Root framework in order to be able to simulate the response and trigger performance of the detector with AliRoot.

  4. Comparative alteration mineral mapping using visible to shortwave infrared (0.4-2.4 μm) Hyperion, ALI, and ASTER imagery

    USGS Publications Warehouse

    Hubbard, B.E.; Crowley, J.K.; Zimbelman, D.R.

    2003-01-01

    Advanced Land Imager (ALI), Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), and Hyperion imaging spectrometer data covering an area in the Central Andes between Volcan Socompa and Salar de Llullaillaco were used to map hydrothermally altered rocks associated with several young volcanic systems. Six ALI channels in the visible and near-infrared wavelength range (0.4-1.0 ??m) were useful for discriminating between ferric-iron alteration minerals based on the spectral shapes of electronic absorption features seen in continuum-removed spectra. Six ASTER channels in the short wavelength infrared (1.0-2.5 ??m) enabled distinctions between clay and sulfate mineral types based on the positions of band minima related to Al-OH vibrational absorption features. Hyperion imagery embedded in the broader image coverage of ALI and ASTER provided essential leverage for calibrating and improving the mapping accuracy of the multispectral data. This capability is especially valuable in remote areas of the earth where available geologic and other ground truth information is limited.

  5. First-principles study of zinc-blende BxAlyIn1-x-yN quaternary alloy: Alchemical mixing approximation approach

    NASA Astrophysics Data System (ADS)

    Bamgbose, M. K.; Adebambo, P. O.; Badmus, B. S.; Dare, E. O.; Akinlami, J. O.; Adebayo, G. A.

    2016-08-01

    Detailed first-principle calculations of properties in zinc blende quaternary alloy BxAlyIn1-x-yN at various concentrations are investigated using density functional theory (DFT) within virtual crystal approximation (VCA) implemented in alchemical mixing approximation. The calculated bandgaps show direct transitions at Γ-Γ and indirect transitions at Γ-X, which are opened by increasing boron concentration. The density of state (DOS) revealed upper valence band (VB1) domination by p-states atoms, while s-states dominate the lower valence band (VB2); also, the DOS shows the contribution of d-states to the conduction band. The first critical point in the dielectric constant ranges between 0.07-4.47 eV and is due to the first threshold optical transitions in the energy bandgap. Calculated static dielectric function (DF) 𝜖1(0) is between 5.15 and 10.35, an indication that small energy bandgaps yield large static DFs. The present results indicate ZB-BxAlyIn1-x-yN alloys are suitable candidates of deep ultraviolet light emitting diodes (LEDs), laser diodes (LDs) and modern solar cell since the concentrations x and y make the bandgap and lattice constant of ZB-BxAlyIn1-x-yN quaternary alloys tunable to desirable values.

  6. Discharge Against Medical Advice in the Pediatric Wards in Boo-ali Sina Hospital, Sari, Iran 2010

    PubMed Central

    Mohseni Saravi, Benyamin; Reza Zadeh, Esmaeil; Siamian, Hasan; Yahghoobian, Mahboobeh

    2013-01-01

    Introduction: Since children neither comprehended nor contribute to the decision, discharge against medical advice is a challenge of health care systems in the world. Therefore, the current study was designed to determine the rate and causes of discharge against medical advice. Methods: This descriptive cross-sectional study was done by reviewing the medical records by census method. Data was analyzed using SPSS software and x2 statistics was used to determine the relationship between variables. The value of P<0.05 was considered significant. Results: Rate of discharged against medical advice was 108 (2.2%). Mean of age and length of stay were 2.8±4 (SD).3 years old and 3.7±5.4 (SD) days, respectively. Totally, 95 patients (88.7%) had health insurance and 65 (60.2%) patients lived in urban areas. History of psychiatric disease and addiction in 22 (20.6%) of the parents were negative. In addition, 100 (92.3%) patients admitted for medical treatment and the others for surgery. The relationship of the signatory with patients (72.3%) was father. Of 108 patients discharged against medical advice, 20 (12%) were readmitted. The relationship between the day of discharge and discharge against medical advice was significant (ρ =0/03). Conclusion: Rate of discharge against medical advice in Boo-ali hospital is the same as the other studies in the same range. The form which is used for this purpose did not have suitable data elements about description of consequence of such discharge, and it has not shown the real causes of discharge against medical advice. PMID:24554800

  7. Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI.

    PubMed

    Lakshmi, Sowmya P; Reddy, Aravind T; Naik, Meghna U; Naik, Ulhas P; Reddy, Raju C

    2012-11-01

    Transmigration of neutrophils (PMNs) from the vasculature into inflamed tissues, mediated by interactions between PMNs and adhesion molecules on endothelial cells, is an essential aspect of inflammation. The crucial adhesion molecules include junctional adhesion molecule (JAM)-A. Investigation of the role of this molecule in models of inflammatory disease has been limited, however, and results in different disease models have varied. No previous study has addressed JAM-A in lung disease or effects on oxidant stress and proinflammatory cytokines. We use JAM-A knockout mice and blocking antibodies to investigate the role of JAM-A in a murine model of acute lung injury (ALI). With either experimental system, we find that absence of JAM-A activity significantly reduces migration of PMNs into the alveolar space, with a resulting decrease in oxidative stress. However, there is no reduction in whole lung activity of PMN-associated myeloperoxidase, presumably reflecting the histologically observed retention of PMNs in lung tissue. Activity of these retained PMNs may account for our failure to find significant change in markers of lung oxidative stress or cytokine and chemokine levels in plasma, lung, and bronchoalveolar lavage fluid. We likewise see no JAM-A-related changes in markers of capillary permeability or lung injury. A similar lack of congruence between effects on PMN migration and tissue injury has been reported in other disease models and for other adhesion molecules in models of ALI. Our results thus confirm the crucial role of JAM-A in PMN transmigration but demonstrate that transmigration is not essential for other aspects of inflammation or for lung injury in ALI.

  8. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

    PubMed

    Zhang, Ting; Liu, Yong; Yang, Xianshu; Martin, Gary E; Yao, Huifang; Shang, Jackie; Bugianesi, Randal M; Ellsworth, Kenneth P; Sonatore, Lisa M; Nizner, Peter; Sherer, Edward C; Hill, Susan E; Knemeyer, Ian W; Geissler, Wayne M; Dandliker, Peter J; Helmy, Roy; Wood, Harold B

    2016-03-10

    A potent and selective Factor IXa (FIXa) inhibitor was subjected to a series of liver microsomal incubations, which generated a number of metabolites. Using automated ligand identification system-affinity selection (ALIS-AS) methodology, metabolites in the incubation mixture were prioritized by their binding affinities to the FIXa protein. Microgram quantities of the metabolites of interest were then isolated through microisolation analytical capabilities, and structurally characterized using MicroCryoProbe heteronuclear 2D NMR techniques. The isolated metabolites recovered from the NMR experiments were then submitted directly to an in vitro FIXa enzymatic assay. The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS assay was completely consistent with the enzymatic assay results. This work showcases an innovative and efficient approach to uncover structure-activity relationships (SARs) and guide drug design via microisolation-structural characterization and ALIS capabilities.

  9. A protocol for improving mapping and assessing of seagrass abundance along the West Central Coast of Florida using Landsat TM and EO-1 ALI/Hyperion images

    NASA Astrophysics Data System (ADS)

    Pu, Ruiliang; Bell, Susan

    2013-09-01

    Seagrass habitats are characteristic features of shallow waters worldwide and provide a variety of ecosystem functions. Remote sensing techniques can help collect spatial and temporal information about seagrass resources. In this study, we evaluate a protocol that utilizes image optimization algorithms followed by atmospheric and sunglint corrections to the three satellite sensors [Landsat 5 Thematic Mapper (TM), Earth Observing-1 (EO-1) Advanced Land Imager (ALI) and Hyperion (HYP)] and a fuzzy synthetic evaluation technique to map and assess seagrass abundance in Pinellas County, FL, USA. After image preprocessed with image optimization algorithms and atmospheric and sunglint correction approaches, the three sensors' data were used to classify the submerged aquatic vegetation cover (%SAV cover) into 5 classes with a maximum likelihood classifier. Based on three biological metrics [%SAV, leaf area index (LAI), and Biomass] measured from the field, nine multiple regression models were developed for estimating the three biometrics with spectral variables derived from the three sensors' data. Then, five membership maps were created with the three biometrics along with two environmental factors (water depth and distance-to-shoreline). Finally, seagrass abundance maps were produced by using a fuzzy synthetic evaluation technique and five membership maps. The experimental results indicate that the HYP sensor produced the best results of the 5-class classification of %SAV cover (overall accuracy = 87% and Kappa = 0.83 vs. 82% and 0.77 by ALI and 79% and 0.73 by TM) and better multiple regression models for estimating the three biometrics (R2 = 0.66, 0.62 and 0.61 for %SAV, LAI and Biomass vs. 0.62, 0.61 and 0.55 by ALI and 0.58, 0.56 and 0.52 by TM) for creating seagrass abundance maps along with two environmental factors. Combined our results demonstrate that the image optimization algorithms and the fuzzy synthetic evaluation technique were effective in mapping

  10. Geochemistry of rare earth elements in the Baba Ali magnetite skarn deposit, western Iran - a key to determine conditions of mineralisation

    NASA Astrophysics Data System (ADS)

    Zamanian, Hassan; Radmard, Kaikosrov

    2016-03-01

    The Baba Ali skarn deposit, situated 39 km to the northwest of Hamadan (Iran), is the result of a syenitic pluton that intruded and metamorphosed the diorite host rock. Rare earth element (REE) values in the quartz syenite and diorite range between 35.4 and 560 ppm. Although the distribution pattern of REEs is more and less flat and smooth, light REEs (LREEs) in general show higher concentrations than heavy REEs (HREEs) in different lithounits. The skarn zone reveals the highest REE-enriched pattern, while the ore zone shows the maximum depletion pattern. A comparison of the concentration variations of LREEs (La-Nd), middle REEs (MREEs; Sm-Ho) and HREEs (Er-Lu) of the ore zone samples to the other zones elucidates two important points for the distribution of REEs: 1) the distribution patterns of LREEs and MREEs show a distinct depletion in the ore zone while representing a great enrichment in the skarn facies neighbouring the ore body border and decreasing towards the altered diorite host rock; 2) HREEs show the same pattern, but in the exoskarn do not reveal any distinct increase as observed for LREEs and MREEs. The ratio of La/Y in the Baba Ali skarn ranges from 0.37 to 2.89. The ore zone has the highest La/Y ratio. In this regard the skarn zones exhibit two distinctive portions: 1) one that has La/Y >1 beingadjacent to the ore body and; 2) another one with La/Y < 1 neighbouring altered diorite. Accordingly, the Baba Ali profile, from the quartz syenite to the middle part of the exoskarn, demonstrates chiefly alkaline conditions of formation, with a gradual change to acidic towards the altered diorite host rocks. Utilising three parameters, Ce/Ce*, Eu/Eu* and (Pr/Yb)n, in different minerals implies that the hydrothermal fluids responsible for epidote and garnet were mostly of magmatic origin and for magnetite, actinolite and phlogopite these were of magmatic origin with low REE concentration or meteoric water involved.

  11. First-principles study of the magnetic and electronic properties of AMnAs (A=Li, Na, K, Rb, Cs)

    NASA Astrophysics Data System (ADS)

    Zhou, Wenqi; Wu, Shuxiang; Li, Shuwei

    2016-12-01

    Recent studies have demonstrated that antiferromagnetic (AFM) semiconductors are promising alternative materials for spintronic applications. In this work, we report a detailed investigation of the magnetic and electronic properties of AMnAs (A=Li, Na, K, Rb, Cs) using density functional theory. It is found that all studied compounds are ordered antiferromagnetically in the MnAs ab plane, however, along the c axis, NaMnAs is ordered ferromagnetically which is different from the AFM coupling of other materials. These results on magnetic structures are in good agreement with observed facts. Furthermore, our calculations predict that all materials have a semiconducting band structure, which indicates the potential of device applications.

  12. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties

    PubMed Central

    Han, Wenjun; Gu, Jingyan; Cheng, Yuanyuan; Liu, Huihui; Li, Yuezhong

    2015-01-01

    Alginate lyases are important tools for oligosaccharide preparation, medical treatment, and energy bioconversion. Numerous alginate lyases have been elucidated. However, relatively little is known about their substrate degradation patterns and product-yielding properties, which is a limit to wider enzymatic applications and further enzyme improvements. Herein, we report the characterization and module truncation of Aly5, the first alginate lyase obtained from the polysaccharide-degrading bacterium Flammeovirga. Aly5 is a 566-amino-acid protein and belongs to a novel branch of the polysaccharide lyase 7 (PL7) superfamily. The protein rAly5 is an endolytic enzyme of alginate and associated oligosaccharides. It prefers guluronate (G) to mannuronate (M). Its smallest substrate is an unsaturated pentasaccharide, and its minimum product is an unsaturated disaccharide. The final alginate digests contain unsaturated oligosaccharides that generally range from disaccharides to heptasaccharides, with the tetrasaccharide fraction constituting the highest mass concentration. The disaccharide products are identified as ΔG units. While interestingly, the tri- and tetrasaccharide fractions each contain higher proportions of ΔG to ΔM ends, the larger final products contain only ΔM ends, which constitute a novel oligosaccharide-yielding property of guluronate lyases. The deletion of the noncatalytic region of Aly5 does not alter its M/G preference but significantly decreases the enzymatic activity and enzyme stability. Notably, the truncated protein accumulates large final oligosaccharide products but yields fewer small final products than Aly5, which are codetermined by its M/G preference to and size enlargement of degradable oligosaccharides. This study provides novel enzymatic properties and catalytic mechanisms of a guluronate lyase for potential uses and improvements. PMID:26519393

  13. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties.

    PubMed

    Han, Wenjun; Gu, Jingyan; Cheng, Yuanyuan; Liu, Huihui; Li, Yuezhong; Li, Fuchuan

    2015-10-30

    Alginate lyases are important tools for oligosaccharide preparation, medical treatment, and energy bioconversion. Numerous alginate lyases have been elucidated. However, relatively little is known about their substrate degradation patterns and product-yielding properties, which is a limit to wider enzymatic applications and further enzyme improvements. Herein, we report the characterization and module truncation of Aly5, the first alginate lyase obtained from the polysaccharide-degrading bacterium Flammeovirga. Aly5 is a 566-amino-acid protein and belongs to a novel branch of the polysaccharide lyase 7 (PL7) superfamily. The protein rAly5 is an endolytic enzyme of alginate and associated oligosaccharides. It prefers guluronate (G) to mannuronate (M). Its smallest substrate is an unsaturated pentasaccharide, and its minimum product is an unsaturated disaccharide. The final alginate digests contain unsaturated oligosaccharides that generally range from disaccharides to heptasaccharides, with the tetrasaccharide fraction constituting the highest mass concentration. The disaccharide products are identified as ΔG units. While interestingly, the tri- and tetrasaccharide fractions each contain higher proportions of ΔG to ΔM ends, the larger final products contain only ΔM ends, which constitute a novel oligosaccharide-yielding property of guluronate lyases. The deletion of the noncatalytic region of Aly5 does not alter its M/G preference but significantly decreases the enzymatic activity and enzyme stability. Notably, the truncated protein accumulates large final oligosaccharide products but yields fewer small final products than Aly5, which are codetermined by its M/G preference to and size enlargement of degradable oligosaccharides. This study provides novel enzymatic properties and catalytic mechanisms of a guluronate lyase for potential uses and improvements.

  14. TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).

    PubMed

    Tang, Mengjie; Tian, Yihao; Li, Doulin; Lv, Jiawei; Li, Qun; Kuang, Changchun; Hu, Pengchao; Wang, Ying; Wang, Jing; Su, Ke; Wei, Lei

    2014-01-01

    Acute lung injury (ALI) is an inflammatory disorder associated with reduced alveolar-capillary barrier function and increased pulmonary vascular permeability. Vasodilator-stimulated phosphoprotein (VASP) is widely associated with all types of modulations of cytoskeleton rearrangement-dependent cellular morphology and function, such as adhesion, shrinkage, and permeability. The present studies were conducted to investigate the effects and mechanisms by which tumor necrosis factor-alpha (TNF-α) increases the tight junction permeability in lung tissue associated with acute lung inflammation. After incubating A549 cells for 24 hours with different concentrations (0-100 ng/mL) of TNF-α, 0.1 to 8 ng/mL TNF-α exhibited no significant effect on cell viability compared with the 0 ng/mL TNF-α group (control group). However, 10 ng/mL and 100 ng/mL TNF-α dramatically inhibited the viability of A549 cells compared with the control group (*p<0.05). Monolayer cell permeability assay results indicated that A549 cells incubated with 10 ng/mL TNF-α for 24 hours displayed significantly increased cell permeability (*p<0.05). Moreover, the inhibition of VASP expression increased the cell permeability (*p<0.05). Pretreating A549 cells with cobalt chloride (to mimic a hypoxia environment) increased protein expression level of hypoxia inducible factor-1α (HIF-1α) (*p<0.05), whereas protein expression level of VASP decreased significantly (*p<0.05). In LPS-induced ALI mice, the concentrations of TNF-α in lung tissues and serum significantly increased at one hour, and the value reached a peak at four hours. Moreover, the Evans Blue absorption value of the mouse lung tissues reached a peak at four hours. The HIF-1α protein expression level in mouse lung tissues increased significantly at four hours and eight hours (**p<0.001), whereas the VASP protein expression level decreased significantly (**p<0.01). Taken together, our data demonstrate that HIF-1α acts downstream of TNF-α to

  15. Ionic ASi2N3 (A=Li, Na, K and Rb) stabilized by the covalent Si-N bonding: First-principles calculations

    NASA Astrophysics Data System (ADS)

    Zhang, Huijun; Ren, Jiadong; Wu, Lailei; Zhang, Jingwu

    2017-01-01

    The structural, elastic and electronic properties of LiSi2N3 and its substitutions by Na, K and Rb were investigated through first-principles computations. The expansion of lattice parameters of ASi2N3 from Li, Na, K to Rb is found to be determined by the bond angle of Si-N1-Si, which suggests a possible way to improve the lithium ionic conductivity by substitutions. ASi2N3 (A=Li, Na, K and Rb) shows the similar elastic behaviors, while the electronic band gap gradually decreases from 5.1 to 3.4 eV from LiSi2N3 to RbSi2N3. Interestingly, the analysis of electronic structure, crystal orbital Hamiltonian populations and Bader charges shows that the covalence of Si-N bonding is critical for the stability of ASi2N3 phase. Among ASi2N3 phases, there is a relatively high ionicity in NaSi2N3; the Si-N bond strength in [Si2N3]- net for KSi2N3 and RbSi2N3 is comparable to LiSi2N3, but stronger than NaSi2N3.

  16. Structural phase stability, electronic structure and mechanical properties of alkali metal hydrides AMH4 (A=Li, Na; M=B, AL)

    NASA Astrophysics Data System (ADS)

    Santhosh, M.; Rajeswarapalanichamy, R.

    2016-01-01

    The structural stability of Alkali metal hydrides AMH4 (A=Li, Na; M=B, Al) is analyzed among the various crystal structures, namely hexagonal (P63mc), tetragonal (P42/nmc), tetragonal (P-421c), tetragonal (I41/a), orthorhombic (Pnma) and monoclinic (P21/c). It is observed that, orthorhombic (Pnma) phase is the most stable structure for LiBH4, monoclinic (P21/c) for LiAlH4, tetragonal (P42/nmc) for NaBH4 and tetragonal (I41/a) for NaAlH4 at normal pressure. Pressure induced structural phase transitions are observed in LiBH4, LiAlH4, NaBH4 and NaAlH4 at the pressures of 4 GPa, 36.1 GPa, 26.5 GPa and 46 GPa respectively. The electronic structure reveals that these metal hydrides are wide band gap insulators. The calculated elastic constants indicate that these metal hydrides are mechanically stable at normal pressure.

  17. Raman scattering of magnetic excitations in Y1-x Prx Ba2Cu3-yAlyO7-δ single crystals

    NASA Astrophysics Data System (ADS)

    Rübhausen, M.; Dieckmann, N.; Bock, A.; Merkt, U.; Widder, W.; Braun, H. F.

    1996-11-01

    Magnetic excitations and their role for the superconductivity in cuprate superconductors have been widely discussed in the literature. Here, we present a study of Y1-x Prx Ba2Cu3-yAlyO7-δ single crystals using Raman spectroscopy in an energy range of 50 10000 cm-1 Raman shift. The high energy range is dominated by a two-magnon scattering process at 3J, where J is the superexchange energy. In the Pr-123 single crystal, we find J = 720 cm-1, a damping of the one-magnon states Γ = 200 cm-1, and a resonance energy of 2.79eV for the two-magnon excitation. The two-magnon peak shows a continuous increase of the one-magnon damping with decreasing x and a nearly constant J across the phase transition to the superconductor. Especially, we find a weak two-magnon peak for a superconductor with a Tc = 86 K.

  18. Effect of integrated pest management on controlling zoonotic cutaneous leishmaniasis in Emamzadeh Agha Ali Abbas (AS) District, Isfahan province, 2006-2009

    PubMed Central

    Nilforoushzadeh, Mohammad Ali; Shirani-Bidabadi, Leila; Saberi, Sedigheh; Hosseini, Seyed Mohsen; Jaffary, Fariba

    2014-01-01

    Background: Cutaneous leishmaniasis (CL) is still considered as a health problem in the world. Several methods of control in different regions, together with obtaining integrated information on its natural foci, are needed to decrease its prevalence. This study was designed to evaluate the effects of simultaneous interventions on CL control. Materials and Methods: A standard questionnaire was used to identify patients among pilgrims to Emamzadeh Agha Ali Abbas (Isfahan Province, Iran). Subsequently, three methods of controlling the disease, including, spraying residential buildings with Baygon, baiting with zinc phosphide poisons, changing the vegetative cover of the region, improving the environment, and mounting a mesh on all doors and windows of buildings in residential areas were used. The control measures were then evaluated by comparing the number of pilgrims affected by CL after and before the interventions. Results: While 23 pilgrims (1.4%) were affected with CL before the intervention (pretest), five (0.3%) persons were found to have CL after taking control measures. The Chi-square test did not indicate any significant difference in the relative frequency of CL (P = 0.731). Conclusion: The only scientific method for preventing and controlling zoonotic CL (ZCL) is a combination of the control methods (improving the environment and fighting off the disease districts and vectors) together with changing the vegetative cover of the region. Any measure for controlling this disease must be taken and programmed in accordance with the relevant experts’ views, in coordination with the participation of other organizations and the society. PMID:24818102

  19. Luminescent properties of SrZn2(PO4)2:Tb3+ and its luminescence improvement by incorporating A+ (A=Li, Na, and K)

    NASA Astrophysics Data System (ADS)

    Li, Panlai; Wang, Zhijun; Yang, Zhiping; Guo, Qinglin

    2014-12-01

    A novel green phosphor SrZn2(PO4)2:Tb3+ is synthesized by a high temperature solid-state method, and its luminescent property is investigated. X-ray diffraction patterns of SrZn2(PO4)2:Tb3+ indicate a similarity crystalline phase to SrZn2(PO4)2. SrZn2(PO4)2:Tb3+ shows green emission under 369 nm excitation, and the prominent luminescence in green (544 nm) due to 5D4-7F5 transition of Tb3+. For the 544 nm emission, excitation spectrum has several excitation band from 200 nm to 400 nm. Emission intensity of SrZn2(PO4)2:Tb3+ is influenced by Tb3+ concentration, and concentration quenching effect of Tb3+ in SrZn2(PO4)2 is also observed. With incorporating A+ (A=Li, Na, and K) as compensator charge, the emission intensity of SrZn2(PO4)2:Tb3+ can be obviously enhanced. CIE color coordinates of SrZn2(PO4)2:Tb3+ locate in the green region. The results indicate this phosphor may be a potential application in white LEDs.

  20. InxGa1-xAs/AlyGa1-yAs/AlzGa1-zAs asymmetric step quantum-well middle wavelength infrared detectors

    NASA Astrophysics Data System (ADS)

    Wu, W. G.; Chang, K.; Jiang, D. S.; Li, Y. X.; Zheng, H. Z.; Liu, H. C.

    2001-10-01

    InxGa1-xAs/AlyGa1-yAs/AlzGa1-zAs asymmetric step quantum-well middle wavelength (3-5 μm) infrared detectors are fabricated. The components display photovoltaic-type photocurrent response as well as the bias-controlled modulation of the peak wavelength of the main response, which is ascribed to the Stark shifts of the intersubband transitions from the local ground states to the extended first excited states in the quantum wells, at the 3-5.3 μm infrared atmospheric transmission window. The blackbody detectivity (Dbb*) of the detectors reaches to about 1.0×1010cm Hz1/2/W at 77 K under bias of ±7 V. By expanding the electron wave function in terms of normalized plane wave basis within the framework of the effective-mass envelope-function theory, the linear Stark effects of the intersubband transitions between the ground and first excited states in the asymmetric step well are calculated. The obtained results agree well with the corresponding experimental measurements.

  1. Crystal structures of hydrates of simple inorganic salts. III. Water-rich aluminium halide hydrates: AlCl3 · 15H2O, AlBr3 · 15H2O, AlI3 · 15H2O, AlI3 · 17H2O and AlBr3 · 9H2O.

    PubMed

    Schmidt, Horst; Hennings, Erik; Voigt, Wolfgang

    2014-09-01

    Water-rich aluminium halide hydrate structures are not known in the literature. The highest known water content per Al atom is nine for the perchlorate and fluoride. The nonahydrate of aluminium bromide, stable pentadecahydrates of aluminium chloride, bromide and iodide, and a metastable heptadecahydrate of the iodide have now been crystallized from low-temperature solutions. The structures of these hydrates were determined and are discussed in terms of the development of cation hydration spheres. The pentadecahydrate of the chloride and bromide are isostructural. In AlI(3) · 15H2O, half of the Al(3+) cations are surrounded by two complete hydration spheres, with six H2O in the primary and 12 in the secondary. For the heptadecahydrate of aluminium iodide, this hydration was found for every Al(3+).

  2. A comparison between HfO2/Al2O3 nano-laminates and ternary HfxAlyO compound as the dielectric material in InGaAs based metal-oxide-semiconductor (MOS) capacitors

    NASA Astrophysics Data System (ADS)

    Krylov, Igor; Pokroy, Boaz; Eizenberg, Moshe; Ritter, Dan

    2016-09-01

    We compare the electrical properties of HfO2/Al2O3 nano-laminates with those of the ternary HfxAlyO compound in metal oxide semiconductor (MOS) capacitors. The dielectrics were deposited by atomic layer deposition on InGaAs. Water, ozone, and oxygen plasma were tested as oxygen precursors, and best results were obtained using water. The total dielectric thickness was kept constant in our experiments. It was found that the effective dielectric constant increased and the leakage current decreased with the number of periods. Best results were obtained for the ternary compound. The effect of the sublayer thicknesses on the electrical properties of the interface was carefully investigated, as well as the role of post-metallization annealing. Possible explanations for the observed trends are provided. We conclude that the ternary HfxAlyO compound is more favorable than the nano-laminates approach for InGaAs based MOS transistor applications.

  3. Use of EO-1 Advanced Land Imager (ALI) multispectral image data and real-time field sampling for water quality mapping in the Hirfanlı Dam Lake, Turkey.

    PubMed

    Kavurmacı, Murat; Ekercin, Semih; Altaş, Levent; Kurmaç, Yakup

    2013-08-01

    This paper focuses on the evaluation of water quality variations in Hirfanlı Water Reservoir, which is one of the most important water resources in Turkey, through EO-1 (Earth Observing-1) Advanced Land Imager (ALI) multispectral data and real-time field sampling. The study was materialized in 20 different sampling points during the overpass of the EO-1 ALI sensor over the study area. A multi-linear regression technique was used to explore the relationships between radiometrically corrected EO-1 ALI image data and water quality parameters: chlorophyll a, turbidity, and suspended solids. The retrieved and verified results show that the measured and estimated values of water quality parameters are in good agreement (R (2) >0.93). The resulting thematic maps derived from EO-1 multispectral data for chlorophyll a, turbidity, and suspended solids show the spatial distribution of the water quality parameters. The results indicate that the reservoir has average nutrient values. Furthermore, chlorophyll a, turbidity, and suspended solids values increased at the upstream reservoir and shallow coast of the Hirfanlı Water Reservoir.

  4. Low-Cost Evaluation of EO-1 Hyperion and ALI for Detection and Biophysical Characterization of Forest Logging in Amazonia (NCC5-481)

    NASA Technical Reports Server (NTRS)

    Asner, Gregory P.; Keller, Michael M.; Silva, Jose Natalino; Zweede, Johan C.; Pereira, Rodrigo, Jr.

    2002-01-01

    quantify both the presence and degree of structural disturbance caused by various logging regimes. Our quantitative assessment of Hyperion hyperspectral and ALI multi-spectral data for the detection and structural characterization of selective logging in Amazonia will benefit from data collected through an ongoing project run by the Tropical Forest Foundation, within which we have developed a study of the canopy and landscape biophysics of conventional and reduced-impact logging. We will add to our base of forest structural information in concert with an EO-1 overpass. Using a photon transport model inversion technique that accounts for non-linear mixing of the four biogeophysical indicators, we will estimate these parameters across a gradient of selective logging intensity provided by conventional and reduced impact logging sites. We will also compare our physical ly-based approach to both conventional (e.g., NDVI) and novel (e.g., SWIR-channel) vegetation indices as well as to linear mixture modeling methods. We will cross-compare these approaches using Hyperion and ALI imagers to determine the strengths and limitations of these two sensors for applications of forest biophysics. This effort will yield the first physical ly-based, quantitative analysis of the detection and intensity of selective logging in Amazonia, comparing hyperspectral and improved multi-spectral approaches as well as inverse modeling, linear mixture modeling, and vegetation index techniques.

  5. Evolution and circulation of type-2 vaccine-derived polioviruses in Nad Ali district of Southern Afghanistan during June 2009-February 2011.

    PubMed

    Sharif, Salmaan; Abbasi, Bilal Haider; Khurshid, Adnan; Alam, Muhammad Masroor; Shaukat, Shahzad; Angez, Mehar; Rana, Muhammad Suleman; Zaidi, Syed Sohail Zahoor

    2014-01-01

    Oral polio vaccine has been used successfully as a powerful tool to control the spread of wild polioviruses throughout the world; however, during replication in under immunized children, some vaccine viruses revert and acquire the neurovirulent phenotypic properties. In this study, we describe the evolution and circulation of Vaccine-Derived Polioviruses (VDPVs) in Helmand province of Afghanistan. We investigated 2646 AFP cases of Afghan children from June 2009-February 2011 and isolated 103 (04%) vaccine viruses, 45(1.7%) wild type polioviruses and six (0.22%) type 2 circulating vaccine-derived polioviruses (cVDPVs). These cVDPVs showed 97.7%-98.2% nucleotide and 98%-98.7% amino acid homology in VP1 region on comparison with Sabin type 2 reference strain. All these cVDPVs had two signature mutations of neurovirulent phenotypes and 12 additional mutations in P1 capsid region that might also have contributed to increase neurovirulence and replication. Phylogenetic analysis revealed that all these viruses were closely related and originated from previously reported Sabin like 2 virus from Pakistan which did not conform to the standard definition of VDPVs at that time. It was also observed that initial OPV dose was administered approximately 9 months prior to the collection of first stool specimen of index case. Our findings support that suboptimal surveillance and low routine immunization coverage have contributed to the emergence and spread of these viruses in Afghanistan. We therefore recommend high quality immunization campaigns not only in affected district Nad Ali but also in the bordering areas between Pakistan and Afghanistan to prevent the spread of cVDPVs.

  6. Development of Antisense Therapeutic and Imaging Agents to Detect and Suppress Inducible Nitric Oxide Synthase (iNOS) Expression in Acute Lung Injury (ALI)

    NASA Astrophysics Data System (ADS)

    Shen, Yuefei

    This dissertation focuses on the development and investigation of antisense imaging and therapeutic agents, combined with nanotechnology, to detect and suppress inducible nitric oxide synthase (iNOS) expression for the diagnosis and treatment of acute lung injury (ALI). To achieve this goal, several efforts were made. The first effort was the identification and characterization of high binding affinity antisense peptide nucleic acids (PNAs) and shell-crosslinked knedel-like nanoparticle (SCK)-PNA conjugates to the iNOS mRNA. Antisense binding sites on the iNOS mRNA were first mapped by a procedure for rapidly generating a library of antisense accessible sites on native mRNAs (MASL) which involves reverse transcription of whole cell mRNA extracts with a random oligodeoxynucleotide primer followed by mRNA-specific PCR. Antisense PNAs against the antisense accessible sites were accordingly synthesized and characterized. The second effort was the investigation of cationic shell crosslinked knedel-like nanoparticle (cSCK)-mediated siRNA delivery to suppress iNOS expression for the treatment of ALI. siRNA with its unique gene-specific properties could serve as a promising therapeutic agent, however success in this area has been challenged by a lack of efficient biocompatible transfection agents. cSCK with its nanometer size and positive charge previously showed efficient cellular delivery of phosphorothioate ODNs (oligodeoxynucleotides), plasmid DNA and PNA. Herein, cSCK showed good siRNA binding and facilitated efficient siRNA transfection in HeLa, a mouse macrophage cell line and other human cell lines. cSCK led to greater silencing efficiency than Lipofectamine 2000 in HeLa cells as determined by the viability following transfection with cytotoxic and non-cytotoxic siRNAs, as well in 293T and HEK cells, and was comparable in BEAS-2B and MCF10a cells. The third effort was the preparation of an iNOS imaging probe through electrostatic complexation between a radiolabeled

  7. Conformational preferences of DNA following damage by aristolochic acids: Structural and energetic insights into the different mutagenic potential of the ALI and ALII-N(6)-dA adducts.

    PubMed

    Kathuria, Preetleen; Sharma, Purshotam; Abendong, Minette N; Wetmore, Stacey D

    2015-04-21

    Aristolochic acids (AAI and AAII), produced by the Aristolochiaceae family of plants, are classified as group I (human) carcinogens by the International Agency for Research on Cancer. These acids are metabolized in cells to yield aristolactams (ALI and ALII, respectively), which further form bulky adducts with the purine nucleobases. Specifically, the adenine lesions are more persistent in cells and have been associated with chronic renal diseases and related carcinogenesis. To understand the structural basis of the nephrotoxicity induced by AAs, the ALI-N(6)-dA and ALII-N(6)-dA lesions are systematically studied using computational methods. Density functional theory calculations indicate that the aristolactam moiety intrinsically prefers a planar conformation with respect to adenine. Nucleoside and nucleotide models suggest that the anti and syn orientations about the glycosidic bond are isoenergetic for both adducts. Molecular dynamics simulations and free energy calculations reveal that the anti base-displaced intercalated conformation is the most stable conformer for both types of AL-N(6)-dA adducted DNA, which agrees with previous experimental work on the ALII-N(6)-dA adduct and thereby validates our approach. Interestingly, this conformer differs from the dominant conformations adopted by other N6-linked adenine lesions, including those derived from polycyclic aromatic hydrocarbons. Furthermore, the second most stable syn base-displaced intercalated conformation lies closer in energy to the anti base-displaced intercalated conformation for ALI-N(6)-dA compared to ALII-N(6)-dA. This indicates that a mixture of conformations may be detectable for ALI-N(6)-dA in DNA. If this enhanced conformational flexibility of double-stranded DNA persists when bound to a lesion-bypass polymerase, this provides a possible structural explanation for the previously observed greater nephrotoxic potential for the ALI versus ALII-N(6)-dA adduct. In addition, the structural

  8. Centennial-scale vegetation and climate changes in the Middle Atlas, Morocco: new insights from multi-proxy investigations at Lake Sidi Ali

    NASA Astrophysics Data System (ADS)

    Fletcher, William; Campbell, Jennifer; Joannin, Sebastien; Mischke, Steffen; Zielhofer, Christoph; de Batist, Marc; Mikdad, Abdes

    2016-04-01

    The karstic lakes of the Middle Atlas, Morocco, represent a valuable archive of environmental and climatic change for Northwest Africa. Here we present the results of centennial-scale palynological and charcoal analyses as part of a multiproxy palaeolimnological study of sediment cores from Lake Sidi Ali in the Middle Atlas, Morocco (33° 03 N, 05° 00 W; 2,080 m a.s.l.). Supported by absolute dating including 23 more than twenty AMS 14C dates on pollen concentrates, the record covers the entire Holocene and offers insights into vegetation and climate change at a regionally unprecedented centennial-scale. Pollen assemblages are dominated by steppic herbs, evergreen oaks (Quercus), junipers (Cupressaceae) and Atlantic cedar (Cedrus atlantica). A long-term evolution of the montane vegetation is recorded, reflecting progressive changes in the dominant arboreal taxa and leading to the full establishment of the emblematic cedar forests of the area during the mid-Holocene by 6000 cal BP. Orbital-scale changes in seasonality and growing season moisture availability linked to declining summer insolation are implicated, with a transition from (a) warm, dry summers associated with summer drought tolerant taxa especially evergreen Quercus, high algal productivity in the lake, and high background levels of microcharcoal reflecting distant fire activity during the early Holocene, to (b) cool, relatively humid summers with dominance of montane conifers, declining algal productivity in the lake, and episodic local fire activity during the mid- to late Holocene. Superimposed on the long-term environmental changes are recurrent centennial-scale fluctuations in vegetation composition, reflecting competitive dynamics between the major taxa, initially between steppic and arboreal elements, and later between the major tree taxa. Parallels with hydrological proxies including stable O and C isotopes suggest common responses to climatic drivers (fluctuations in moisture sources and

  9. Petrochemistry of ultrapotassic tephrites and associated cognate plutonic xenoliths with carbonatite affinities from the late Quaternary Qa’le Hasan Ali maars, central Iran

    NASA Astrophysics Data System (ADS)

    Saadat, S.; Stern, C. R.; Moradian, A.

    2014-08-01

    The Quaternary Qa’le Hasan Ali (QHA) maars in central Iran occur at the intersection of the north-south Nayband fault, which defines the western boundary of the Lut micro-continental block, and a system of northwest-southeast faults, subparallel to the Zagros suture zone, that formed during the Arabian-Eurasian collision. These post-collisional maars intrude Eocene volcanic rocks of the Urumieh-Dokhtar magmatic belt, which was generated by the subduction of Neotethys oceanic lithosphere below Iran. The highly potassic, Ti-phlogopite + Mg-rich (Fo89-92) olivine + diopside-augite + aegirine-augite basanite tephrites forming the tuff rims of the QHA maars contain tephrite-coated plutonic xenoliths, some of which are interpreted as co-genetic with the tephrites based on their similar mineralogy and Sr isotopic composition (87Sr/86Sr = 0.70590). Cognate plutonic xenoliths have up to ∼20 vol% calcite, considered to be magmatic calcite because of (1) its grain size, which is similar to feldspars and aegirine-augite pyroxenes in these rocks, (2) the occurrence of fine-grained inclusions of pyroxene and apatite within these calcite grains, and (3) the similarity of the Sr-isotopic composition of this calcite with the other minerals in these rocks. The fact that the magmatic calcite has remained intact and did not volatilize during the transport of these xenoliths to the surface in the hot tephrite magma implies a short transit time, indicating that they are samples of a shallow plutonic complex, as does the presence of anorthoclase in these plutonic xenoliths. Their high modal proportion of magmatic calcite suggests that this shallow plutonic complex has affinities with carbonatites. The magmatic calcite-bearing plutonic xenoliths have high LREE/HREE ratios and contain REE-rich allanite (with up to ∼20 wt% LREE) and britholite (∼60 wt% LREE) that make up ∼3 modal percent of the most calcite-rich samples. Similar to many post-collisional highly potassic rocks

  10. Le champ critique de claquage de films d'oxyde de polyphénylène réalisés par voie électrochimique

    NASA Astrophysics Data System (ADS)

    Adohi, B.; Gosse, J. P.; Gosse, B.

    1991-10-01

    The electrical breakdown of thin films of polyphenylene oxide electrochemically deposited on stainless steel plane substrates has been studied. First it was examined the dependence of the medium surrounding the dielectric and the electrodes (nature, hydrostatic pressure) on the breakdown voltage and on its statistical distribution. Between sphere and plane electrodes, it appears that even for pressurified gases, breakdown of the film is caused by the gas breakdown. We have analysed the discharges occurring at atmosphere pressure in the test cell. Breakdown of the film occurred when the electric field due to the charge deposited on its surface was about 230 V/μm. We have also studied self-healing capacitors with PPO as a dielectric, and determined the life-time of this material. On a étudié le claquage électrique de films minces d'oxyde de polyphénylène de quelques microns d'épaisseur déposés par voie électrochimique sur un plan en acier inoxydable. L'étude a d'abord été faite en rampe de tension continue dans la géométrie d'électrodes sphèreplan, en fonction du milieu ambiant liquide ou gazeux. L'influence de la pression sur la rigidité diélectrique du matériau, les distributions statistiques de Weibull et les cratères formés au moment du claquage, dans les différents milieux et dans les deux polarités de l'électrode sphérique montrent que le claquage du matériau est causé par des décharges qui se produisent dans le milieu environnant. A partir de l'analyse quantitative de ces décharges, on propose comme critère de caractérisation de la rupture d'un matériau sounmis aux décharges, le champ créé au moment de la rupture par les charges déposées à sa surface. On a réalisé ensuite des échantillons plans << autocicatrisables >> par dépôt de couches minces d'aluminium (quelques milliers d'Å d'épaisseur) sur le film de PPO. On étudie dans cette configuration la durée de vie du matériau.

  11. Diffusion, diffraction des neutrons en temps réel et études réalisées in situ

    NASA Astrophysics Data System (ADS)

    Isnard, O.

    2003-02-01

    La diffusion des neutrons est une technique particulièrement efficace pour l'analyse en temps réel des processus réactionnels dans la matière. La diffraction de neutrons in situ a été développée très tôt sur les sources à haut flux tel que l'Institut Laue Langevin. Ces études nécessitent un flux de neutrons important et un détecteur couvrant un domaine angulaire le plus grand possible. Les neutrons offrent la spécificité d'être très peu absorbés par nombre de matériaux, cette faible absorption fait de la diffusion neutronique un excellent outil pour sonder la matière en volume et de manière non destructive. Cela permet en particulier d'utiliser des environnements d'échantillons complexes tout en conservant un flux raisonnable. La diffusion de neutrons en temps réel est donc très largement utilisée par diverses communautés scientifiques : sciences des matériaux, physiciens, chimistes... L'objet de ce cours est de donner les paramètres importants pour ce type d'étude et d'illustrer le propos à l'aide d'exemples pris dans des domaines scientifiques divers : électrochimie, magnétisme, métallurgie, chimie du solide. Après avoir présenté quelques repères méthodologiques sur les méthodes d'acquisition de données, des exemples montreront le fort potentiel de la diffusion neutronique en temps réel pour l'étude de la matière dans des conditions dynamiques. Enfin, nous donnerons aussi quelques conseils pour la visualisation, le dépouillement et l'analyse de ce type d'expérience. La diffusion des neutrons sur poudre est actuellement très bien adaptée aux études réalisées in situ. Cependant, nous verrons que la faisabilité d'études in situ s'étend à d'autres techniques expérimentales telles que la diffusion des neutrons aux petits angles et même la diffusion sur monocristal qui est en plein renouveau.

  12. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology.

    PubMed

    Rehman, Shaheed Ur; Choe, Kevin; Yoo, Hye Hyun

    2016-03-10

    Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50) of the alcoholic extract of E. longifolia in mice is between 1500-2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents' identification, determination, further development and most importantly, the

  13. Aptian Paleoclimates and Identification of an OAE1a Equivalent in Shallow Marine Environments of the Southern Tethyan Margin: The Bir Oum Ali Section, Northern Chott Chain, Southern Tunisia

    NASA Astrophysics Data System (ADS)

    Hfaiedh, R.; Godet, A.; Arnaud-Vanneau, A.; Zghal, I.; Arnaud, H.; Ouali, J.

    2015-12-01

    Alternations between siliciclastic, carbonate and evaporitic sedimentary systems, as recorded in the Aptian mixed succession of southern Tunisia, reflect profound paleoceanographic, paleoclimatic and tectonic changes in this area of the southern Tethyan margin. Whereas the early Aptian is interpreted as having been dominated by slightly humid conditions, the onset of a gypsiferous sedimentation near the early to late Aptian boundary is associated with the appearance of palygorskite and sepiolite, which supports the installation of arid conditions in the study area. The evaporitic sedimentation may have also been promoted by the peculiar tectonic setting of the Bir Oum Ali area during the Aptian, where local subsidence may have been tectonically-enhanced in relation to the opening of northern and central Atlantic. Chemostratigraphic (δ13C) correlation of the Bir Oum Ali succession with other peri-Tethyan regions complements biostratigraphic findings, and indicates that a potential expression of the Oceanic Anoxic Event (OAE) 1a may be preserved in this area of Tunisia. Although the characteristic negative spike in δ13C values located at the base of this event is not recognized in the present study, a subsequent, large positive excursion is of similar amplitude and absolute values to those reported from other peri-tethyan regions. This comparison supports the identification of isotopic segments C4 to C7 of the OAE1a, during which the dominance of macroalgae over other benthic organisms is observed at Bir Oum Ali. The absence of the negative spike may be linked to either non preservation or non deposition: the OAE1a occurred in a global transgressive context, and since the study area was located in the innermost part of the southern Tethyan margin during most of the Aptian, stratigraphic hiatuses may have been longer than in other regions of the Tethys.

  14. Palaeomagnetism and K-Ar and 40Ar/39Ar ages in the Ali Sabieh area (Republic of Djibouti and Ethiopia): constraints on the mechanism of Aden ridge propagation into southeastern Afar during the last 10 Myr

    NASA Astrophysics Data System (ADS)

    Audin, L.; Quidelleur, X.; Coulié, E.; Courtillot, V.; Gilder, S.; Manighetti, I.; Gillot, P.-Y.; Tapponnier, P.; Kidane, T.

    2004-07-01

    A new detailed palaeomagnetic study of Tertiary volcanics, including extensive K-Ar and 40Ar/39Ar dating, helps constrain the deformation mechanisms related to the opening processes of the Afar depression (Ethiopia and Djibouti). Much of the Afar depression is bounded by 30 Myr old flood basalts and floored by the ca 2 Myr old Stratoid basalts, and evidence for pre-2 Ma deformation processes is accessible only on its borders. K-Ar and 40Ar/39Ar dating of several mineral phases from rhyolitic samples from the Ali Sabieh block shows indistinguishable ages around 20 Myr. These ages can be linked to separation of this block in relation to continental breakup. Different amounts of rotation are found to the north and south of the Holhol fault zone, which cuts across the northern part of the Ali Sabieh block. The southern domain did not record any rotation for the last 8 Myr, whereas the northern domain experienced approximately 12 +/- 9° of clockwise rotation. We propose to link this rotation to the counter-clockwise rotation observed in the Danakil block since 7 Ma. This provides new constraints on the early phases of rifting and opening of the southern Afar depression in connection with the propagation of the Aden ridge. A kinematic model of propagation and transfer of extension within southern Afar is proposed, with particular emphasis on the previously poorly-known period from 10 to 4 Ma.

  15. Luminescent properties of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} and its luminescence improvement by incorporating A{sup +} (A=Li, Na, and K)

    SciTech Connect

    Li, Panlai Wang, Zhijun Yang, Zhiping; Guo, Qinglin

    2014-12-15

    A novel green phosphor SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} is synthesized by a high temperature solid-state method, and its luminescent property is investigated. X-ray diffraction patterns of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} indicate a similarity crystalline phase to SrZn{sub 2}(PO{sub 4}){sub 2}. SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} shows green emission under 369 nm excitation, and the prominent luminescence in green (544 nm) due to {sup 5}D{sub 4}–{sup 7}F{sub 5} transition of Tb{sup 3+}. For the 544 nm emission, excitation spectrum has several excitation band from 200 nm to 400 nm. Emission intensity of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} is influenced by Tb{sup 3+} concentration, and concentration quenching effect of Tb{sup 3+} in SrZn{sub 2}(PO{sub 4}){sub 2} is also observed. With incorporating A{sup +} (A=Li, Na, and K) as compensator charge, the emission intensity of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can be obviously enhanced. CIE color coordinates of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} locate in the green region. The results indicate this phosphor may be a potential application in white LEDs. - Graphical abstract: SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can produce green emission under near-UV excitation, and its luminescent properties can be improved by incorporating A{sup +} (A=Li, Na, and K). - Highlights: • SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} can produce green emission under near-UV excitation. • Concentration quenching effect of Tb{sup 3+} in SrZn{sub 2}(PO{sub 4}){sub 2} is observed. • Emission intensities of SrZn{sub 2}(PO{sub 4}){sub 2}:Tb{sup 3+} are enhanced by codoped A{sup +} (A=Li, Na, K)

  16. Native-oxide-masked Si impurity-induced layer disordering of AlxGa1 - xAs-AlyGa1 - yAs-AlzGa1 - zAs quantum-well heterostructures

    NASA Astrophysics Data System (ADS)

    El-Zein, N.; Holonyak, N., Jr.; Kish, F. A.; Sugg, A. R.; Richard, T. A.; Dallesasse, J. M.; Smith, S. C.; Burnham, R. D.

    1991-08-01

    Data are presented showing that the native oxide that can be formed on high Al composition AlxGa1-xAs (x≳0.7) confining layers commonly employed on AlxGa1-xAs-AlyGa1-yAs-AlzGa1-zAs (y≳z) superlattices or quantum-well heterostructures serves as an effective mask against Si diffusion, and thus impurity-induced layer disordering. The high-quality native oxide is produced by the conversion of high-composition AlxGa1-xAs (x≳0.7) confining layers via H2O vapor oxidation (≳400 °C) in N2 carrier gas.

  17. Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.

    PubMed

    2016-10-01

    The above article, published online on June 21, 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figure 5A to be inappropriately manipulated. Literature Cited Ali S, Banerjee S, Logna F, Bao B, Philip PA, Korc M, Sarkar FH. 2012. Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer. J Cell Physiol 227:3373-3380; doi: 10.1002/jcp.24036.

  18. Retraction: "Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer" by Ali et al.

    PubMed

    2016-08-01

    The above article, published online on March 8, 2010 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, Gary S. Stein, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation from Wayne State University involving the first author and the corresponding author that found Figures 2A, 4, 6A, and 6C to be inappropriately manipulated. REFERENCE Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA, Sarkar FH. 2010. Concurrent inhibition of NF-κB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J Cell Biochem 110:171-181; doi: 10.1002/jcb.22523.

  19. Characterization and Electrochemical Performance of SubstitutedLiNi0.4Co0.2-yAlyMn0.4O2 (0<_y<_0.2) Cathode Materials

    SciTech Connect

    Wilcox, James D.; Doeff, Marca M.

    2007-11-28

    A complete series of LiNi0.4Co0.2-yAlyMn0.4O2 (0<_y<_0.2) materials have been synthesized and investigated as cathode materials for lithium ion batteries. When cycled between 2.0 and 4.3 V vs. Li/Li+ at a current density of 0.1 mA/cm2, stable capacities of ~;;160 mAh/g for y=0 to ~;;110 mAh/g for y=0.2 are achieved. Upon increasing the current density, it is found that all materials containing aluminum show reduced polarization and improved rate performance. The optimal performance at all current densities was found for the compound with y=0.05. The effect of aluminumsubstitution on the crystal structure of the host is discussed.

  20. Application of multivariate statistical analysis and hydrochemical and isotopic investigations for evaluation of groundwater quality and its suitability for drinking and agriculture purposes: case of Oum Ali-Thelepte aquifer, central Tunisia.

    PubMed

    Hassen, Imen; Hamzaoui-Azaza, Fadoua; Bouhlila, Rachida

    2016-03-01

    Groundwater plays a dominant role in arid regions; it is among the most available water resources in Tunisia. Located in northwestern Tunisia, Oum Ali-Thelepte is a deep Miocene sedimentary aquifer, where groundwater is the most important source of water supply. The aim of the study is to investigate the hydrochemical processes leading to mineralization and to assess water quality with respect to agriculture and drinking for a better management of groundwater resources. To achieve such objectives, water analysis was carried out on 16 groundwater samples collected during January-February 2014. Stable isotopes and 26 hydrochemical parameters were examined. The interpretation of these analytical data showed that the concentrations of major and trace elements were within the permissible level for human use. The distribution of mineral processes in this aquifer was identified using conventional classification techniques, suggesting that the water facies gradually changes from Ca-HCO3 to Mg-SO4 type and are controlled by water-rock interaction. These results were endorsed using multivariate statistical methods such as principal component analysis and cluster analysis. The sustainability of groundwater for drinking and irrigation was assessed based on the water quality index (WQI) and on Wilcox and Richards's diagrams. This aquifer has been classified as "excellent water" serving good irrigation in the area. As for the stable isotope, the measurements showed that groundwater samples lay between global meteoric water line (GMWL) and LMWL; hence, this arrangement signifies that the recharge of the Oum Ali-Thelepte aquifer is ensured by rainwater infiltration through mountains in the border of the aquifer without evaporation effects.

  1. Le diagnostic anténatal de la trisomie 21 par l'hybridation in situ en fluorescence (FISH): à propos des premiers tests réalisés au Maroc

    PubMed Central

    Lamzouri, Afaf; Natiq, Abdelhafid; Tajir, Mariam; Sendid, Mohamed; Sefiani, Abdelaziz

    2012-01-01

    Introduction Le but de cette étude était de présenter les premiers résultats de diagnostic anténatal de la trisomie 21 par la technique d'hybridation in situ en fluorescence (FISH) au Maroc et discuter son intérêt dans le diagnostic rapide de cette aneuploïdie. Méthodes Ce travail a été réalisé chez 23 femmes avec des grossesses à haut risque de trisomie 21. La moyenne d’âge des gestantes étaient de 37,43 ans avec des extrêmes de 21 et 43 ans. Toutes étaient musulmanes mariées, mariage légitimé par la Charia, dont trois mariages consanguins, sauf une originaire de la République Démocratique du Congo qui était chrétienne et concubine. La majorité des femmes étaient fonctionnaires et avaient un niveau de scolarisation moyen à élevé. Toutes les patientes ont bénéficié d'une consultation de génétique médicale au cours de laquelle il leur a été donné des informations sur la technique, son intérêt et ses limites. Il s'agit de femmes enceintes qui avaient soit un âge maternel élevé ou des signes d'appel échographiques et/ ou biochimiques. Une des patientes était porteuse d'une translocation robertsonienne t(14;21) équilibrée. Une amniocentèse a été réalisée chez toutes les gestantes et aucun avortement n'a était induit par ce geste invasif. L’âge gestationnel moyen à la première consultation était de 14 semaines d'aménorrhée (SA) et à l'amniocentèse était de 16 SA et 5 jours. L'analyse FISH a été réalisée, après consentement des couples, sur des cellules non cultivées à partir des échantillons de liquides amniotiques, en utilisant des sondes spécifiques du chromosome 21. Résultats Parmi les 23 patientes qui ont bénéficiées d'un diagnostic anténatal de la trisomie 21 par la technique FISH, nous avons pu rassurer 21 d'entre elles, et nous avons détecté deux cas de trisomie 21 fœtal. Conclusion La technique FISH permet un diagnostic anténatal rapide, en moins de 48h, de la trisomie 21 sur

  2. Hydrothermal synthesis, structures and optical properties of A2Zn3(SeO3)4·XH2O (A=Li, Na, K; X=2 or 0)

    NASA Astrophysics Data System (ADS)

    Liu, Yunsheng; Mei, Dajiang; Xu, Jingli; Wu, Yuandong

    2015-12-01

    New alkali metal zinc selenites, A2Zn3(SeO3)4·XH2O (A=Li, Na, K; X=2 or 0) were prepared through hydrothermal reactions. Li2Zn3(SeO3)4·2H2O (1) crystallizes in the monoclinic space group P21/c with lattice parameters a=8.123(4), b=9.139(4), c=7.938(3) Å, β=112.838(9)°. Na2Zn3(SeO3)4·2H2O (2) crystallizes in the monoclinic space group C2/c with lattice parameters a=15.7940(18), b=6.5744(8), c=14.6787(17) Å, β=107.396(3)°. K2Zn3(SeO3)4 (3) crystallizes in the monoclinic space group C2/c with lattice parameters a=11.3584(12), b=8.6091(9), c=13.6816(14) Å, β=93.456(2)°. The anionic structures are composed of [Zn3O12]18- sheets, chains, and "isolated" units in compound 1, 2, 3, respectively, and trigonal pyramids SeO32-. The compounds were characterized by the solid state UV-vis-NIR diffuse reflectance spectroscopy, infrared spectra and thermogravimetric analysis.

  3. Crystal structure and ionic conductivity of ruthenium diphosphate ARu{sub 2}(P{sub 2}O{sub 7}){sub 2}, A=Li, Na, and Ag, with a tunnel structure

    SciTech Connect

    Fukuoka, Hiroshi; Matsunaga, Hideyuki; Yamanaka, Shoji

    2003-05-26

    Crystal structure and ionic conductivity of ruthenium diphosphates, ARu{sub 2}(P{sub 2}O{sub 7}){sub 2} A=Li, Na, and Ag, were investigated. The structure of the Ag compound was determined by single crystal X-ray diffraction techniques. It crystallized in the triclinic space group P-1 with a=4.759(2) A, b=6.843(2) A, c=8.063(1) A, {alpha}=90.44(2) deg., {beta}=92.80(2) deg., {gamma}=104.88(2) deg., V=253.4(1) A{sup 3}. The host structure of it was composed of RuO{sub 6} and P{sub 2}O{sub 7} groups and formed tunnels running along the a-axis, in which Ag{sup +} ions were situated. The ionic conductivities have been measured on pellets of the polycrystalline powders. The Li and Ag compounds showed the conductivities of 1.0x10{sup -4} and 3.5x10{sup -5} S cm{sup -1} at 150 deg. C, respectively. Magnetic susceptibility measurement of the Ag compound showed that it did not obey the Curie-Weiss law and the effective magnetic moment decreased as temperature decreased due to the large spin-orbital coupling effect of Ru{sup 4+} ions.

  4. Pratique de la prophylaxie de la maladie thromboembolique veineuse: enquête réalisée auprès des professionnels de santé de la ville de Ouagadougou

    PubMed Central

    Naibe, Dangwe Temoua; Samadoulougou, André; Kabore, Hervé; Yameogo, Relwendé Aristide; Millogo, Georges; Yameogo, Nobila Valentin; Kologo, Jonas Koudougou; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2014-01-01

    Introduction L'impact clinique et l'incidence de la maladie thromboembolique veineuse ont conduit à établir des recommandations pour la thromboprophylaxie. L'objectif de notre étude était d’évaluer la pratique de cette prophylaxie par les professionnels de santé de Ouagadougou. Méthodes Il s'est agi d'une enquête d'intention réalisée dans le mois de mai 2012 au Centre Hospitalier Universitaire Yalgado Ouédraogo et Centre Médical avec Antenne chirurgicale Paul VI. Un questionnaire a été administré auprès des prescripteurs impliqués dans la prophylaxie de la maladie thromboembolique veineuse (MTEV). Résultats Une interview a été administrée à 86 professionnels de santé dont 20 attachés de santé en anesthésie-réanimation, 17 chirurgiens, 11 médecins généralistes et 07 gynécologue-obstétriciens. Leur expérience professionnelle était inférieure à cinq ans dans 65% des cas et ils exerçaient dans 70% des cas au CHU-YO. Les héparines de bas poids moléculaire étaient les plus utilisées (81,4%) avec une intention de prescription significativement plus élevée en réanimation et en chirurgie (p<0,05). Dans 65,7% des cas, la prophylaxie était maintenue jusqu'à la mobilisation des patients. Le coût élevé de l'héparinothérapie représentait une raison de la non utilisation de la prophylaxie dans 46,5% des cas. Conclusion Nous constatons que la réalisation de la prophylaxie de la MTEV reste insuffisante à Ouagadougou en dépit de l'existence de recommandations précises de bonnes pratiques. Ces résultats suggèrent la nécessité de la formation médicale continue des professionnels de santé, avec l’établissement des recommandations de pratique clinique adaptée à notre niveau de développement. PMID:25995791

  5. Participation du patient Marocain atteint du cancer au choix thérapeutique: résultat d'une enquête réalisée auprès de 272 patient

    PubMed Central

    Boukir, Anwar; Azghari, Ilham; El Kabous, Mustapha; Jouid, Khalid; Boutayeb, Saber; El Ghissassi, Ibrahim; Mrabti, Hind; Errrihani, Hassan

    2015-01-01

    Introduction La décision médicale partagée ‘Shared decision making’ est un concept qui se développe depuis les années 1990. Il donne aux patients le soutien nécessaire pour exprimer leurs préférences et partager la décision médicale. Cette étude cherche à estimer le degré de participation du patient Marocain atteint de cancer au choix thérapeutique. Méthodes Cette enquête a été réalisée auprès de 272 malades sous chimiothérapie pour une pathologie cancéreuse sous forme d'un entretien verbal basé sur un questionnaire. Les patients ont été sélectionnés selon un mode d’échantillonnage aléatoire, le nombre de patients a été choisi pour une marge d'erreur de 5% et un seuil de probabilité qui approxime les 90%. Résultats Seulement 5.5% des patients dans l'enquête ont participé activement dans le choix thérapeutique. Pour 94% des patients de l’échantillon la stratégie thérapeutique adoptée par le médecin est la bonne et représente l'option optimale. Les principales causes retrouvées qui expliquent la non participation à la décision thérapeutique sont le bas niveau d'instruction, la non réceptivité à l'information ainsi que des défauts majeures dans la transmission et la perception de l'information. Conclusion Ces résultats prouvent que la relation médecin malade dans notre contexte baigne toujours dans le modèle paternaliste. La responsabilité de la décision thérapeutique est le plus souvent laissée au médecin. Il est nécessaire d'informer et d'impliquer le patient de façon active dans le choix thérapeutique afin de mieux sauvegarder la relation médecin-malade qui doit être fondée sur la confiance ainsi que sur une approche participative. PMID:26918070

  6. Résultats de la chirurgie avancée de la cataracte par tunnélisation: à propos de 262 cas réalisés au CHR de Banfora (Burkina Faso)

    PubMed Central

    Djiguimdé, Pierre Windinmanégdé; Diomandé, Ibrahim Abib; Ahnoux-Zabsonré, Ahgbatouhabéba; Koffi, Konan Virgile; Meda, Tierinyê Armand; Diomandé, Gossé François; Sanou, Jerôme; Meda-Hien, Gertude; Sankara, Paté; Meda, Nonfounikoun

    2015-01-01

    La cataracte demeure la première cause de cécité dans les pays en voie de développement posant un problème de santé publique. Le but de cette étude est de faire le bilan d'une activité de chirurgie avancée de la cataracte par la technique dite de « phacoalternative » ou par tunnélisation. Il s'agissait d'une étude prospective de base réalisée au Burkina Faso portant sur la chirurgie de la cataracte par la technique de tunnélisation. L’âge moyen de nos patients atteints de cataracte était de 62,47 ± 12,77 ans avec un sex-ratio de 0,98. La majorité des patients opérés (82,82%) étaient des cultivateurs et des ménagères. L'acuité visuelle de loin était réduite à la perception lumineuse dans 68,70% des cas. La profondeur moyenne de la chambre antérieure était de 2,98 ± 0,53 mm. L’épaisseur moyenne du cristallin était de 3,55 ± 0,75 mm. La longueur axiale moyenne de l’œil de nos patients opérés de la cataracte était de 22,88 ± 0,90 mm. La puissance réfractive moyenne estimée de la cornée était de 43,21 ± 2,03 dioptries chez nos patients. La puissance moyenne estimée de l'implant intra oculaire (IOL) utilisé était de23,11 ± 2,35D. La majorité (79,6%) de nos patients avait une bonne acuité visuelle après la chirurgie de la cataracte par tunnélisation. La chirurgie de la cataracte par tunnélisation est une technique révolutionnaire adaptée aux pays pauvres d'Afrique. Elle permet une lutte efficace à moindre coût contre la cécité par cataracte dans nos régions. La tunnélisation est une technique chirurgicale adaptée pour lutter efficacement contre la cécité due à la cataracte en Afrique. PMID:27022426

  7. Science, Science Education and Their Discontents: A Response to Commentaries on the Paper, "Portrait of a Science Teacher as a Bricoleur--A Case Study from India"

    ERIC Educational Resources Information Center

    Sharma, Ajay

    2008-01-01

    In this response to commentaries by Ali Sammel, Jhumki Basu and Alberto Rodriguez, I present my perspective on three important issues raised by the commentators. These issues relate to the role of a researcher in her field settings and society, the critique of science and science education as oppressive dominant discourses, and co-opting…

  8. For the relief of Jose de Jesus Ibarra, Monica Ibarra Rodriguez, and Cristina Gamez.

    THOMAS, 111th Congress

    Rep. Johnson, Eddie Bernice [D-TX-30

    2009-01-08

    02/02/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. A diverse assemblage of Anacardiaceae from Oligocene sediments, Tepexi de Rodriguez, Puebla, Mexico.

    PubMed

    Ramírez, José L; Cevallos-Ferriz, Sergio R S

    2002-03-01

    Among the plants collected from the Pie de Vaca Formation of the Oligocene, of Tepexi de Rodríguez, Puebla, México are five plants of Anacardiaceae, Haplorhus medranoensis, Rhus toxicodendron, Rhus sp., Comocladia intermedia, and Pistacia marquezii represented by their leaves and/or leaflets. The past and present diversity and geographic distribution of one of these genera, Rhus, demonstrate its capability to adapt and diversify in a wide variety of environments. Leaf architecture characters of this taxon overlap with those of other genera in the family, suggesting a high degree of phenotypic plasticity. The presence in the Pie de Vaca Formation of a type of Pistacia with leaf architecture characters similar to those of Asian plants further supports a long history of exchange between low-latitude North America and Asia. Links between low-latitude North and South America and the Caribbean are suggested by the presence of Comocladia and Haplorhus. Whereas Comocladia highlights the long history of regional endemics in the area, Haplorhus, today an endemic monotypic genus of Peru, suggests exchange mechanisms between North and South America. The morphologic characters of these taxa, and those of Pseudosmodingium (Anacardiaceae), some Rosaceae, Leguminosae, and Berberidaceae, suggest that the Pie de Vaca community was established and evolved in harsh environmental conditions. The Pie de Vaca flora thus provides significant new insights into the biogeographic relationships of the low latitude vegetation of North America.

  10. VizieR Online Data Catalog: Spectra of IPHAS symbiotic stars (Rodriguez-Flores+, 2014)

    NASA Astrophysics Data System (ADS)

    Rodriguez-Flores, E. R.; Corradi, R. L. M.; Mampaso, A.; Garcia-Alvarez, D.; Munari, U.; Greimel, R.; Rubio-Diez, M. M.; Santander-Garcia, M.

    2014-04-01

    We obtained spectra for 18 candidate symbiotic stars in May, June, and December 2012 at the 10.4m Gran Telescopio Canarias (GTC) at the Observatorio del Roque de los Muchachos (La Palma, Spain). The OSIRIS instrument was used in its long-slit mode. The combination of grism R1000B and a slit width of 1" provides a spectral dispersion of 2.1Å per (binned x2) pixel, a resolution of 7Å, and a spectral coverage from 3650 to 7850Å. Exposure times ranged between 100s and 800s, depending of the magnitude of each object. (2 data files).

  11. Business Is Looking Up: Featuring Renaldo Rodriguez. The Kids on the Block Book Series.

    ERIC Educational Resources Information Center

    Aiello, Barbara; Shulman, Jeffrey

    One of a series of children's books written from the point of view of an elementary grade child with a disability or other problem, the stories emphasize similarities in childhood experience while providing information specific to the disability. In this book, 11-year-old Renaldo, visually impaired since birth, sets up a greeting card service for…

  12. Implications of the Serrano and Rodriguez Cases on the Education of Mexican Americans.

    ERIC Educational Resources Information Center

    Gonzalez, Simon

    The primary local funding source for school support has always been the property or "ad valorum" tax. State funds, determined for each district by the "foundation program" formula, supplement this tax. Local school boards, state legislatures, state constitutions, and the voters have the power to provide quality education. In…

  13. Mentoring Matters: Many Voices, Many Choices--Women Who Mentored and Inspired Dana Rodriguez

    ERIC Educational Resources Information Center

    Powell, Mary G.

    2011-01-01

    In this essay, the author traces the progress of one English teacher (Dana) from her days as a middle school student, to her university work, to her emergence as a teacher. The journey reveals that many mentors along the way contributed to the new teacher's sense of purpose, efficacy, and confidence. It is easy to limit one's thinking about the…

  14. Magnetic polarity stratigraphy of "Mexican Solnhofen" Tlayua Formation, Tepexi de Rodriguez, State of Puebla, Mexico

    NASA Astrophysics Data System (ADS)

    Urrutia Fucugauchi, J.; Zhao, X.; Girdler, S.; Coe, R.; Gogichaishvili, A.; Benammi, M.; Alvarado-Ortega, J.; Urrutia-Fucugauchi, J.

    2005-05-01

    The Tlayua Formation is the richest Cretaceous fossiliferous locality in Mexico. Research in the quarry has yielded thousands of fossil fish associated with other vertebrate remains. From a vertical section, a total of 95 paleomagnetic specimens from 31 horizons were measured to determine the paleomagnetic signal. Limestones are weakly magnetized and exhibit in general two component magnetizations. The magnetic properties and characteristic remanence are dominated by soft and hard coercivity magnetic minerals, most of which probably formed early in the depositional and diagenetic history. Rock-magnetic properties and a positive reversal test suggest that remanence is primary. The section displays both reverse and normal polarities with mean directions: D = 344.9°, I = 32.4°, k= 21, a95= 4.2°; and D = 149.4°, I = -36.6°, k= 17, a95= 8.7°. Comparison with the North America reference curve, indicates tectonic stability of the region since the Cretaceous. Correlation of these polarity zones with the geomagnetic polarity time scale provides a time framework for the discrepancy of the previous biochronological studies. Based on biostratigraphic age assignments using ammonites, the polarity magnetozone sequence correlates with C34n.1n-C34n.2n chrons, with an age of 100 to 105 Ma for the Tlayua Formation.

  15. VizieR Online Data Catalog: Young star groups in NGC 300 (Rodriguez+, 2016)

    NASA Astrophysics Data System (ADS)

    Rodriguez, M. J.; Baume, G.; Feinstein, C.

    2016-08-01

    Fundamental characteristics of 1147 young star groups identified in 6 ACS/WFC fields of the galaxy NGC 300. For each group: field of the ACS/WFC, equatorial coordinates, radius, number of stars (the suffix bri indicates bright stars with F555W<25, the suffix dct indicate stars belonging to the decontaminated region, the suffixes blue and red refer to blue and red stars respectively), the magnitude of the brightest star in the group, PDMF slope with its error, and galactocentric distance. (1 data file).

  16. Caractérisation électrique des interfaces P^+-Si-poly/N-c-Si réalisées par dépôt LPCVD de films fortement dopés in~situ au bore

    NASA Astrophysics Data System (ADS)

    Akani, M.; Benouis, C. E.; Benzohra, M.

    1993-08-01

    Diodes with polycrystalline in situ boron doped emitter deposited by LPCVD on N doped monocrystalline silicon wafers have been analysed electrically with the aim to identify the conduction mechanism through the jonction. In this paper we present the I(V,T) and C (V, T) measurements of the diodes annealed at 1 050 °C during 11 min 45 s in oxygen, argon and nitrogen atmosphere. We also compare the non annealed diode data previously found with our present results, and try to correlate the electrical measurements to the structural analysis [1]. We conclude that the dominant mechanism shows the electrical quality of the studied structures. Des diodes à émetteur polycristallin dopé in situ au bore et déposé par LPCVD sur des plaquettes de silicium monocristallin dopé N sont analysées électriquement dans le but d'identifier les mécanismes de conduction à travers la jonction. Nous présentons les résultats des mesures I (V, T) et C (V, T) des diodes recuites (processées) à 1 050 °C pendant 11 min 45 s dans des atmosphères d'oxygène, d'argon et d'azote et les comparons aux résultats des diodes non recuites. Nous essayons de corréler les résultats des mesures électriques aux analyses de structure réalisées par ailleurs [1]. L'identification du mécanisme de transport prépondérant témoignera de la qualité électrique des structures étudiées.

  17. Ibn Sina, Abu Ali [known as Avicenna] (980-1037)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Islamic philosopher and scientist, born in Kharmaithen, near Bukhara (now Uzbekistan). Avicenna's life was marked by swings of fortune, from physician and favored scholar of a Samanid prince, to peripatetic country doctor when the Samanid regime fell. He became court physician in Hamadan (Iran), where he was for a time imprisoned as a political prisoner. He ended his life in a peaceful, contem...

  18. Qal'eh Hasan Ali maars, central Iran.

    USGS Publications Warehouse

    Milton, D.J.

    1976-01-01

    This group of some 15 Late Quaternary explosion craters are typical maars, with rims of bedded pyroclastics. In all but the largest crater, the deposits consist entirely of clasts of country rock (granodiorite and Eocene volcanics). The maars were formed by phreatomagmatic explosions, possibly caused by groundwater originating from a major river. The deposits of the largest maar contain up to 20% juvenile fragments of two types. Tephrite clasts have phenocrysts of phlogopite, clinopyroxene, olivine and anorthoclase; the presence of hauyne as a groundmass phase is notable. Cumulate blocks of phlogopite-clinopyroxene rock also occur. The maar field is part of a distinct province of Quaternary alkaline volcanism, related to a major crustal fracture - the N-S-trending Nayband fault.-R.J.S.

  19. Preliminary Image Map of the 2007 Witch and Poomacha Fire Perimeters, Rodriguez Mountain Quadrangle, San Diego County, California

    USGS Publications Warehouse

    Clark, Perry S.; Scratch, Wendy S.; Bias, Gaylord W.; Stander, Gregory B.; Sexton, Jenne L.; Krawczak, Bridgette J.

    2008-01-01

    In the fall of 2007, wildfires burned out of control in southern California. The extent of these fires encompassed large geographic areas that included a variety of landscapes from urban to wilderness. The U.S. Geological Survey National Geospatial Technical Operations Center (NGTOC) is currently (2008) developing a quadrangle-based 1:24,000-scale image map product. One of the concepts behind the image map product is to provide an updated map in electronic format to assist with emergency response. This image map is one of 55 preliminary image map quadrangles covering the areas burned by the southern California wildfires. Each map is a layered, geo-registered Portable Document Format (.pdf) file. For more information about the layered geo-registered .pdf, see the readme file (http://pubs.usgs.gov/of/2008/1029/downloads/CA_Agua_Dulce_of2008-1029_README.txt). To view the areas affected and the quadrangles mapped in this preliminary project, see the map index (http://pubs.usgs.gov/of/2008/1029/downloads/CA_of2008_1029-1083_index.pdf) provided with this report.

  20. China’s Global Quest for Energy

    DTIC Science & Technology

    2007-01-01

    consumption rate.30 Despite statements made by Venezuelan officials, such as Ali Rodriguez, president of Venezuela’s state-owned oil company, PDVSA , who...1994). Petroleos de Venezuela ( PDVSA ): A state-owned Venezuelan oil company. 20 Rosneft: The only Russian oil company that is completely state...Laverdad. 25 Charles Roth, “Venezuela Plan to Sell US Oil Ops Flawed – Ex- PdVSA Pres,” FWN Select, 2 February 2005, Rigzone, <http://www.rigzone.com> (2

  1. Development and Evaluation of Processes for Deposition of Ni/Co-Cr-Aly (MCrAly) Coatings for Gas Turbine Components.

    DTIC Science & Technology

    1979-09-01

    turbine engines demand increasingly higher operating tem- peratures in blades and vanes for greater thrust and efficiency. The turbine components...limitations; namely, expense and the inability to uniformly coat complex geometries and clustered turbine blade and vane airfoils . Thus, another means of...cost and the ability to uniformly coat turbine components of complex geometries and clustered turbine blade and vane airfoils .

  2. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 16. (Prime Mover Company, The-Rodriguez General Contractors)

    DTIC Science & Technology

    1988-01-01

    ntneW) -4 in (a0 I.Nrr. -WOV f P1 . t- NNNN (0-P w in N- U4nn (0wa- I NNICS NI -4-4 a0. 0.0 a .w I) N NN IWA0 - I LA-I U. . in In C.)L000 N 0 V)M i...4-4-4-4-4 Cy I 00Ios 1 C- NC14-4 ""N N -4-4-4-4 .- 4 -4-I4-4 4 -0 N U OW) r r- I.- - - - P,41 P1 - f . -r 󈧄V I 0000000 100.0 1 0000000 IV0o~ I...0(0. P. P1 %N1=1=N .4 N.4 4 40 -4 ..4..4 .- 140 110000000 40 40 0000000I0-NNO I 1- 10- 100 0 00 V0I Ogg~>(. I 000)C)MI) 0 000000 O 000C4 ON N NNNCM4

  3. Presentation of Guillermo Rodriguez, Jr., Chair, California Postsecondary Education Commission to the Citizens Commission on Higher Education, University of California at Berkeley, Bechtel Engineering Center (September 10, 1998).

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    This presentation identifies six areas of common interest between the California Postsecondary Education Commission (CPEC) and the Citizens Commission on Higher Education: (1) California needs to plan more effectively for the anticipated enrollment growth, particularly at the community college level; (2) the State ought to create a long-term…

  4. Materials Data on La3(AlI)2 (SG:12) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2014-07-09

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  5. Ali, Cunich: Halley's Churches: Halley and the London Queen Anne Churches

    NASA Astrophysics Data System (ADS)

    Ali, Jason R.; Cunich, Peter

    2005-04-01

    Edmond Halley's enormous contribution to science has received much attention. New research adds an intriguing chapter to his story and concerns his hitherto unexplored association with the baroque architectural visionary Nicholas Hawksmoor, and some important Temple-inspired churches that were built in London in the early 1700s. We argue that Christchurch Spitalfields and St Anne's Limehouse, which were both started in the summer of 1714, were aligned exactly eastwards using ``corrected'' magnetic-compass bearings and that Halley influenced or aided Hawksmoor. By this time the men had probably known each other for 30 years and had recently worked together on the Clarendon Building in Oxford. Despite there being more than 1500 years of Chinese and about 500 years of Western compass technology at the time, these probably represent the first constructions planned using a modern-day ``scientific'' technique. The research also throws light on Halley's contended religious position.

  6. The Al(I) molecule, Ph2COAl and its anion

    NASA Astrophysics Data System (ADS)

    Zhang, Xinxing; Eichhorn, Bryan; Schnöckel, Hansgeorg; Bowen, Kit

    2016-08-01

    We have formed the Al(I)-containing molecule, benzophenone-aluminum, i.e., Ph2COAl, and studied it by conducting density functional theory calculations on both its neutral and anionic forms and by measuring the photoelectron spectrum of its anion. Our calculations identified two nearly iso-energetic anion isomers, (Ph2COAl)-, the vertical detachment energies (VDE) of which are in excellent agreement with our photoelectron spectrum. Natural population analysis (NPA) of Ph2COAl found the Al moiety to be positively charged by +0.81 e, indicating a strongly ionic bond between Al and Ph2CO, i.e., Ph2CO-Al+.

  7. Oxidation resistant and low coefficient of thermal expansion Nia1-CoCrAly alloy

    NASA Technical Reports Server (NTRS)

    Hebsur, Mohan G. (Inventor)

    2004-01-01

    A bond coat composition for use in thermal barrier coatings comprises a NiAl--CoCrAlY matrix containing particles of AlN dispersed therein. The bond coat composition is prepared by croymilling NiAl and CoCrAlY in liquid nitrogen.

  8. Approximating tasseled cap values to evaluate brightness, greenness, and wetness for the Advanced Land Imager (ALI)

    USGS Publications Warehouse

    Yamamoto, Kristina H.; Finn, Michael P.

    2012-01-01

    The Tasseled Cap transformation is a method of image band conversion to enhance spectral information. It primarily is used to detect vegetation using the derived brightness, greenness, and wetness bands. An approximation of Tasseled Cap values for the Advanced Land Imager was investigated and compared to the Landsat Thematic Mapper Tasseled Cap values. Despite sharing similar spectral, temporal, and spatial resolution, the two systems are not interchangeable with regard to Tasseled Cap matrices.

  9. The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali.

    PubMed

    Maziah, Mahmood; Rosli, Noormi

    2009-01-01

    Plant cell culture technology is potentially useful in producing high-valued secondary metabolites. Eurycoma longifolia root extracts are consumed as a health tonic but more popularly used as an aphrodisiac. Studies on the aphrodisiac properties and the possible compounds involved have been widely studied. There are many potentially useful compounds reported from the root extracts of E. longifolia. However, studies on the in vitro production of useful compounds from this plant have not been reported. This chapter will describe methods of callus induction and extraction of 9-methoxycanthin-6-one from E. longifolia Jack explants with emphasis on the tap and fibrous roots. This compound, known to have anti-tumour activity, is present in intact plant parts and in callus tissues of different explants.

  10. LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang).

    PubMed

    Chua, Lee Suan; Amin, Nor Amaiza Mohd; Neo, Jason Chun Hong; Lee, Ting Hun; Lee, Chew Tin; Sarmidi, Mohamad Roji; Aziz, Ramlan Abdul

    2011-12-15

    A number of three LC-MS/MS hybrid systems (QTof, TripleTof and QTrap) has been used to profile small metabolites (m/z 100-1000) and to detect the targeted metabolites such as quassinoids, alkaloids, triterpene and biphenylneolignans from the aqueous extracts of Eurycoma longifolia. The metabolite profiles of small molecules showed four significant clusters in the principle component analysis for the aqueous extracts of E. longifolia, which had been collected from different geographical terrains (Perak and Pahang) and processed at different extraction temperatures (35°C and 100°C). A small peptide of leucine (m/z 679) and a new hydroxyl methyl β-carboline propionic acid have been identified to differentiate E. longifolia extracts that prepared at 35°C and 100°C, respectively. From the targeted metabolites identification, it was found that 3,4ɛ-dihydroeurycomanone (quassinoids) and eurylene (squalene-type triterpene) could only be detected in the Pahang extract, whereas canthin-6-one-3N-oxide could only be detected in the Perak extract. Overall, quassinoids were present in the highest concentration, particularly eurycomanone and its derivatives compared to the other groups of metabolites. However, the concentration of canthin-6-one and β-carboline alkaloids was significantly increased when the roots of the plant samples were extracted at 100°C.

  11. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... Institution, P.O. Box 1000, White Deer, PA 17887 and 547 Green Hill Lane, Berwyn, PA 19312. On January 11..., engaged in financial and business transactions with companies in Iran between November 1996 and June 2008..., P.O. Box 1000, White Deer, PA 17887, and 547 Green Hill Lane, Berwyn, PA 19312, and when acting...

  12. A Computer Code for the Calculation of NLTE Model Atmospheres Using ALI

    NASA Astrophysics Data System (ADS)

    Kubát, J.

    2003-01-01

    A code for calculation of NLTE model atmospheres in hydrostatic and radiative equilibrium in either spherically symmetric or plane parallel geometry is described. The method of accelerated lambda iteration is used for the treatment of radiative transfer. Other equations (hydrostatic equilibrium, radiative equilibrium, statistical equilibrium, optical depth) are solved using the Newton-Raphson method (linearization). In addition to the standard output of the model atmosphere (dependence of temperature, density, radius, and population numbers on column mass depth) the code enables optional additional outputs for better understanding of processes in the atmosphere. The code is able to calculate model atmospheres of plane-parallel and spherically symmetric semi-infinite atmospheres as well as models of plane parallel and spherical shells. There is also an option for solution of a restricted problem of a NLTE line formation (solution of radiative transfer and statistical equilibrium for a given model atmosphere). The overall scheme of the code is presented.

  13. Development and Evaluation of Game-Like Phonological Awareness Software for Kindergarteners: "JerenAli"

    ERIC Educational Resources Information Center

    Kartal, Günizi; Terziyan, Treysi

    2016-01-01

    The major goal of this study was to develop a game-like software application for phonological awareness training and to evaluate its role in improving phonological awareness skills at the kindergarten level, with the intention to eventually help reading acquisition in Turkish. The participants of the study came from two kindergarten classrooms in…

  14. ALI (Autonomous Lunar Investigator): Revolutionary Approach to Exploring the Moon with Addressable Reconfigurable Technology

    NASA Technical Reports Server (NTRS)

    Clark, P. E.; Curtis, S. A.; Rilee, M. L.; Floyd, S. R.

    2005-01-01

    Addressable Reconfigurable Technology (ART) based structures: Mission Concepts based on Addressable Reconfigurable Technology (ART), originally studied for future ANTS (Autonomous Nanotechnology Swarm) Space Architectures, are now being developed as rovers for nearer term use in lunar and planetary surface exploration. The architecture is based on the reconfigurable tetrahedron as a building block. Tetrahedra are combined to form space-filling networks, shaped for the required function. Basic structural components are highly modular, addressable arrays of robust nodes (tetrahedral apices) from which highly reconfigurable struts (tetrahedral edges), acting as supports or tethers, are efficiently reversibly deployed/stowed, transforming and reshaping the structures as required.

  15. Recommended ALIs and DACs for 10 CFR part 220: A consistent numerical set

    SciTech Connect

    Eckerman, K.F.

    1996-05-01

    Appendix B to 10 CFR Part 20 contains numerical data for controlling the intake of radionuclides in the workplace or in the environment. These data, derived from the recommendations of the International Commission on Radiological Protection (ICRP), do not provide a numerically consistent basis for demonstrating compliance with the limitation on dose stated in the regulation. This situation is largely a consequence of the numerical procedures used by the ICRP which did not maintain, in a strict numerical sense, the hierarchial relationship among the radiation protection quantities. In this work recommended values of the quantities in Appendix B to CFR Part 20 are developed using the dose coefficients of the applicable ICRP publications and a numerical procedure which ensures that the tabulated quantities are numerically consistent.

  16. Referring the bill (H.R. 798), entitled "For the relief of Adrian Rodriguez", to the chief judge of the United States Court of Federal Claims for a report thereon.

    THOMAS, 111th Congress

    Rep. Filner, Bob [D-CA-51

    2009-02-03

    03/16/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  17. Oxidation resistant and low coefficient of thermal expansion NiA1-CoCrAly alloy

    NASA Technical Reports Server (NTRS)

    Hebsur, Mohan G. (Inventor)

    2002-01-01

    A bond coat composition for use in thermal barrier coatings comprises a NiAl--CoCrAlY matrix containing particles of AlN dispersed therein. The bond coat composition is prepared by croymilling NiAl and CoCrAlY in liquid nitrogen.

  18. VizieR Online Data Catalog: PCF, SpecB or SDSSB asteroids parameters (Ali-Lagoa+, 2016)

    NASA Astrophysics Data System (ADS)

    Ali-Lagoa, V.; Licandro, J.; Gil-Hutton, R.; Canada-Assandri, M.; Delbo, M.; de Leon, J.; Campins, H.; Pinilla-Alonso, N.; Kelley, M. S. P.; Hanus, J.

    2016-04-01

    The table contains the best-fitting values of size and beaming parameter and corresponding visible geometric albedos for all our objects. We fitted the near-Earth asteroid thermal model of Harris (1998Icar..131..291H) to WISE/NEOWISE thermal infrared data (see, e.g., Mainzer et al., 2011ApJ...736..100M and Masiero et al., 2014ApJ...791..121M). Minimum relative errors of 10, 15, and 20 percent should be considered for size, beaming parameter and albedo in those cases for which the beaming parameter could be fitted. Otherwise, a default value of the beaming parameter is assumed (its negative value is given in the table) and the minimum relative errors in size and albedo increase to 20 and 40 percent (see, e.g., Mainzer et al., 2011ApJ...736..100M). We also provide the asteroid absolute magnitudes and slope parameters retrieved from the Minor Planet Center (MPC), the number of observations used in each WISE band (W3 and W4), plus the corresponding average values of heliocentric and geocentric distances and phase angle (r, g, a) based on the ephemerides taken from the MIRIADE service (http://vo.imcce.fr/webservices/miriade/?ephemph). The subsample label indicates whether the object belongs to the SDSS, spectroscopic B or PCF groups. Labels with the suffix 'qA' indicate that only data with signal-to- noise ratio greater than 10 were used for that case (see Appendix A of the article for more details). (1 data file).

  19. [Etiological and pathogenetic aspects of joint diseases in Abu Ali Ibn Sina's papers and their modern significance].

    PubMed

    Abduvaliev, A A

    2006-01-01

    It is established that the basis of theoretical background on etiological and pathogenetic aspects of joint diseases have been made in connection with an ancient doctrine of elements, basic qualities, joint fluid and mizadj. Pathological process in a joint is associated with quantitative-qualitative changes of structure of joint fluid and its penetration into the joint with subsequent change of mizadj. The doctrine about mizadj is the main idea of Avicenna on health and illness and also the basis of signs of all system of human being, which are significant during diagnostics. The study of reasons and mechanisms of illnesses of the locomotor system against Avicenna's positions will throw light, for sure, on many unresolved problems of modern arthroloogy.

  20. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Californium Cf 98 Carbon C 6 Cerium Ce 58 Cesium Cs 55 Chlorine Cl 17 Chromium Cr 24 Cobalt Co 27 Copper Cu 29... Ru 44 Samarium Sm 62 Scandium Sc 21 Selenium Se 34 Silicon Si 14 Silver Ag 47 Sodium Na 11...

  1. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Californium Cf 98 Carbon C 6 Cerium Ce 58 Cesium Cs 55 Chlorine Cl 17 Chromium Cr 24 Cobalt Co 27 Copper Cu 29... Ru 44 Samarium Sm 62 Scandium Sc 21 Selenium Se 34 Silicon Si 14 Silver Ag 47 Sodium Na 11...

  2. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Californium Cf 98 Carbon C 6 Cerium Ce 58 Cesium Cs 55 Chlorine Cl 17 Chromium Cr 24 Cobalt Co 27 Copper Cu 29... Ru 44 Samarium Sm 62 Scandium Sc 21 Selenium Se 34 Silicon Si 14 Silver Ag 47 Sodium Na 11...

  3. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Californium Cf 98 Carbon C 6 Cerium Ce 58 Cesium Cs 55 Chlorine Cl 17 Chromium Cr 24 Cobalt Co 27 Copper Cu 29... Ru 44 Samarium Sm 62 Scandium Sc 21 Selenium Se 34 Silicon Si 14 Silver Ag 47 Sodium Na 11...

  4. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... different radionuclides. It should be noted that the classification of a compound as Class D, W, or Y is based on the chemical form of the compound and does not take into account the radiological half-life of different radioisotopes. For this reason, values are given for Class D, W, and Y compounds, even for...

  5. Genetics Home Reference: craniofacial microsomia

    MedlinePlus

    ... 9. doi: 10.3174/ajnr.A2072. Epub 2010 Mar 18. Review. Citation on PubMed Johnson JM, Moonis ... hemifacial microsomia. Arch Otolaryngol Head Neck Surg. 2001 Mar;127(3):265-71. Citation on PubMed Tasse ...

  6. A new species and new records of Cryptodacus (Diptera: Tephritidae) from Colombia, Bolivia and Peru

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cryptodacus bernardoi Rodriguez & Rodriguez, new species, is described from Colombia. It was reared from fruits of Phoradendron sp. near piperoides (Kunth) Trel. New distribution records are reported for Cryptodacus ornatus Norrbom from Colombia and Peru, for Cryptodacus trinotatus Norrbom & Korytko...

  7. Active Knits for Radical Change Air Force Structures

    DTIC Science & Technology

    2012-10-01

    displacement) performance by using the individual elements as building blocks or unit cells. For example, piezoelectric [35] and dielectric elastomer ...example, piezoelectric Moonies [40], Cymbals [41], and X-frames [42], dielectric elastomer spiders [43], and smart material levers all provide actuation...to create shaped, distributed planar actuation. Dielectric elastomer bowties [43] and flexible frames [43] employ an external frame to pre-stress

  8. SDIO Workshop on Piezoelectric Ceramic Actuators for Space Applications Held in Alexandria, Virginia on 25 February 1992

    DTIC Science & Technology

    1992-06-01

    processes can be found on pages D-81 to D-83. 26 The piezoceramic material of interest is PZT-5H. 2-9 metallized (for electrodes) 27, and hot-pressed...forces and displacements. The moonie actuators5 consist of a piezoceramic disk sandwiched between two shaped metal electrodes, each having a flat...choice of metal for the electrodes is important since the metal does most of the straining during actuation. The stress state of the metal electrode

  9. Magnetic and electrical behavior of La 1-xA xMnO 3 (A=Li, Na, K and Rb) manganites

    NASA Astrophysics Data System (ADS)

    Kalyana Lakshmi, Y.; Venkataiah, G.; Vithal, M.; Venugopal Reddy, P.

    2008-09-01

    With a view to understand the magnetic and electrical behavior of monovalent substituted lanthanum manganites, a series of materials were prepared by sol-gel route by sintering at 1200 °C. The X-ray diffraction data were analyzed using Rietveld refinement technique and it has been found that all the samples were found to crystallize into rhombohedral structure with R3barc space group. The values of ferro to paramagnetic ( TC) and metal-insulator transition ( TP) temperatures were obtained using ac susceptibility and electrical resistivity data, respectively. It has been found that sodium-, potassium- and rubidium-doped samples exhibit two peaks in the electrical resistivity vs. temperature plots. The observed behavior has been explained on the basis of oxygen deficiency present in the samples. The electrical resistivity data were analyzed using various theoretical models and it has been concluded that the electrical resistivity data in the low-temperature regime ( T< TP) can be explained using the equation ρ(T)= ρ0+ ρ2T2+ ρ4.5T4.5, signifying the importance of the grain/domain boundary, electron-electron and two magnon scattering processes. On the other hand, the high-temperature resisitivity data ( T> TP) were explained using variable range and small polaron hopping mechanisms.

  10. Structural and Electrochemical Investigation of Li(Ni0.4Co0.2-yAlyMn0.4)O2 Cathode Material

    SciTech Connect

    Rumble, C.; Conry, T.E.; Doeff, Marca; Cairns, Elton J.; Penner-Hahn, James. E.; Deb, Aniruddha

    2010-02-02

    Li(Ni{sub 0.4}Co{sub 0.2-y}Al{sub y}Mn{sub 0.4})O{sub 2} with y=0.05 was investigated to understand the effect of replacement of the cobalt by aluminum on the structural and electrochemical properties. The effect of the substitution was studied by in-situ X-ray absorption spectroscopy (XAS), utilizing a novel in situ electrochemical cell, specifically designed for long-term X-ray experiments. The cell was cycled at a moderate rate through a typical Li-ion battery operating voltage range (1.0-4.7 V). XAS measurements were performed at different states-of-charge (SOC) during cycling, at the Ni, Co, and the Mn edges, revealing details about the response of the cathode to Li insertion and extraction processes. The extended X-ray absorption fine structure region of the spectra revealed the changes of bond distance and coordination number of Ni, Co, and Mn absorbers as a function of the SOC of the material. The oxidation states of the transition metals in the system are Ni{sup 2+}, Co{sup 3+}, and Mn{sup 4+} in the as-made material (fully discharged), while during charging the Ni{sup 2+} is oxidized to Ni{sup 4+} through an intermediate stage of Ni{sup 3+}, Co{sup 3+} is oxidized towards Co{sup 4+} and Mn was found to be electrochemically inactive and remains as Mn{sup 4+}. The EXAFS results during cycling show that the Ni-O changes the most, followed by Co-O and Mn-O varies the least. These measurements on this cathode material confirmed that the material retains its symmetry and good structural short-range order leading to the superior cycling reported earlier.

  11. Structural and electrochemical Investigation of Li(Ni0.4Co0.2-yAlyMn0.4)O2 Cathode Material

    SciTech Connect

    Rumble, C.; Conry, T.E.; Doeff, Marca; Cairns, Elton J.; Penner-Hahn, James E.; Deb, Aniruddha

    2010-06-14

    Li(Ni{sub 0.4}Co{sub 0.15}Al{sub 0.05}Mn{sub 0.4})O{sub 2} was investigated to understand the effect of replacement of the cobalt by aluminum on the structural and electrochemical properties. In situ X-ray absorption spectroscopy (XAS) was performed, utilizing a novel in situ electrochemical cell, specifically designed for long-term X-ray experiments. The cell was cycled at a moderate rate through a typical Li-ion battery operating voltage range. (1.0-4.7 V) XAS measurements were performed at different states of charge (SOC) during cycling, at the Ni, Co, and the Mn edges, revealing details about the response of the cathode to Li insertion and extraction processes. The extended X-ray absorption fine structure (EXAFS) region of the spectra revealed the changes of bond distance and coordination number of Ni, Co, and Mn absorbers as a function of the SOC of the material. The oxidation states of the transition metals in the system are Ni{sup 2+}, Co{sup 3+}, and Mn{sup 4+} in the as-made material (fully discharged), while during charging the Ni{sup 2+} is oxidized to Ni{sup 4+} through an intermediate stage of Ni{sup 3+}, Co{sup 3+} is oxidized toward Co{sup 4+}, and Mn was found to be electrochemically inactive and remained as Mn{sup 4+}. The EXAFS results during cycling show that the Ni-O changes the most, followed by Co-O, and Mn-O varies the least. These measurements on this cathode material confirmed that the material retains its symmetry and good structural short-range order leading to the superior cycling reported earlier.

  12. Barriers of the Development of Web-Based Training in Agricultural Higher Education System in Iran: A Case Study of Hamadan Bu Ali Sina University, Iran

    ERIC Educational Resources Information Center

    Saadi, Heshmatollah; Mirzayi, Khalil; Movahedi, Reza

    2016-01-01

    Recently, higher education systems seek to use network-based and Internet-based information technologies in education, teaching and learning. E-learning in Iran higher education system has been started since 2003, however, its development has been very slow. The present study is a survey research. The participants of the study are faculty members,…

  13. Exposure to Sodium Dichromate at Qarmat Ali Iraq in 2003: Part 2 -- Evaluation of Army and Contractor Actions Related to Hazardous Industrial Exposure

    DTIC Science & Technology

    2011-09-28

    the day. In early June 2003, KBR returned the plant to partial operating capacity, with subcontracted Halliburton employees operating pumps on...dated August 8, 2003, that stated, “ Halliburton hands will wear a paper mask and goggles…” However, we observed the material safety data sheet for

  14. Controlling the compositional inhomogeneities in AlxGa1-xN/AlyGa1-yN MQWs grown by PA-MBE: Effect on luminescence properties

    NASA Astrophysics Data System (ADS)

    Pramanik, Pallabi; Sen, Sayantani; Singha, Chirantan; Roy, Abhra Shankar; Das, Alakananda; Sen, Susanta; Bhattacharyya, Anirban; Kumar, Deepak; Sridhara Rao, D. V.

    2016-04-01

    Al0.35Ga0.65N/Al0.55Ga0.45N MQWs were grown by PA-MBE using a range of group III/V flux ratios. TEM images indicate sharp interfaces and well/barrier widths of 1.5/2 nm. We observe that small variations of group III/V flux ratio cause dramatic variations in the room temperature photoluminescence (PL) spectra. In addition to band edge luminescence, multiple low energy PL peaks are observed for growths under excess group III conditions, which are absent for near-stoichiometric growth. Temperature dependent PL measurements indicate that at room temperature, emission occurs due to transitions at potential fluctuations generated by the presence of compositional inhomogeneity. These effects are dominant for growth under excess group III conditions due to the presence of a metallic layer on the growth surface during deposition. This can be eliminated by the use of an Indium surfactant during growth, which modifies the diffusion length of Ga and Al adatoms. Under these conditions, the optical properties of MQWs are relatively insensitive to variations in group III to V flux ratio and hence substrate temperature, thus making them suitable for industrial-scale fabrication of optoelectronic devices in the ultraviolet range.

  15. Youth Self-Formation and the "Capacity to Aspire": The Itinerant "Schooled" Career of Fuzile Ali across Post-Apartheid Space

    ERIC Educational Resources Information Center

    Fataar, Aslam

    2010-01-01

    This article is a narrative analysis of one young boy's encounter with his schooling across the rural and urban landscape. It is set against the backdrop of the changing social reproductive context of education in South Africa in the democratic period. Based on in-depth qualitative interviews, the analysis probed the subjective basis on which this…

  16. Oxidative Cleavage of C=S and P=S Bonds at an Al(I) Center: Preparation of Terminally Bound Aluminum Sulfides.

    PubMed

    Chu, Terry; Vyboishchikov, Sergei F; Gabidullin, Bulat; Nikonov, Georgii I

    2016-10-10

    The treatment of cyclic thioureas with the aluminum(I) compound NacNacAl (1; NacNac=[ArNC(Me)CHC(Me)NAr](-) , Ar=2,6-Pr(i)2 C6 H3 ) resulted in oxidative cleavage of the C=S bond and the formation of 3 and 5, the first monomeric aluminum complexes with an Al=S double bond stabilized by N-heterocyclic carbenes. Compound 1 also reacted with triphenylphosphine sulfide in a similar manner, which resulted in cleavage of the P=S bond and production of the adduct [NacNacAl=S(S=PPh3 )] (8). The Al=S double bond in 3 can react with phenyl isothiocyanate to furnish the cycloaddition product 9 and zwitterion 10 as a result of coupling between the liberated carbene and PhN=C=S. All novel complexes were characterized by multinuclear NMR spectroscopy, and the structures of 5, 9, and 10 were confirmed by X-ray diffraction analysis. The nature of the Al=S bond in 5 was also probed by DFT calculations.

  17. Is photography-based taxonomy really inadequate, unnecessary, and potentially harmful for biological sciences? A reply to Ceríaco et al.> (2016).

    PubMed

    Thorpe, Stephen E

    2017-01-26

    An opinion piece was recently published in this journal which, remarkably, is less than one page in length, but has 493 authors (signatories) and has gained over 15 thousand reads on ResearchGate in a very short time. Ceríaco et al. (2016) argue for a blanket ban to be imposed on the uncommon practice of basing new species descriptions in zoology on photographic evidence only of the animal. I herein aim to show that their argument is a non sequitur, i.e. their stated reasons do not support their desired conclusion.

  18. Review of Frigitilla Williams in Bartholomay et al.>, 2015, with description of a new species from Panama (Hymenoptera: Mutillidae).

    PubMed

    Cambra, Roberto A; Brothers, Denis J; Quintero, Diomedes

    2016-11-10

    Frigitilla panamensis Cambra, Brothers & Quintero sp. nov., from Panama, based on females, is described and illustrated. This new species represents the northernmost distribution record for the Neotropical genus Frigitilla Williams in Bartholomay et al., 2015. New synonymy and combination are proposed for Frigitilla simulatrix (F. Smith, 1879), comb. nov. =Mutilla frigidula Cresson, 1902, syn. nov. A lectotype is designated for Mutilla simulatrix F. Smith, 1879. The differentiating characters for the genus are briefly discussed.

  19. Acoustic phonon modes in asymmetric AlxGa1-xN/GaN/AlyGa1-yN quantum wells

    NASA Astrophysics Data System (ADS)

    Zan, Y. H.; Ban, S. L.; Chai, Y. J.; Qu, Y.

    2017-02-01

    Using an elastic continuum model, the dispersion relations and phonon modes of propagating, confined, half space and interface acoustic phonons in asymmetric AlxGa1-xN/GaN/Al1-yGayN quantum wells (QWs) have been solved theoretically with the varieties of Al components x and y. Contrary to the previous conclusions, some regulations for the existence of the above different acoustic phonons are revealed as well as the transition conditions among these modes are also discussed. With increase of wave vectors, the dispersion relations split into several groups. Because the classification of these groups is related to the eigen frequencies of bulk materials forming QWs, phonon modes in these groups will be confined or propagating in different layers of QWs. Furthermore, the gradients of the dispersion relations' asymptotes are the velocities of longitudinal and the transverse acoustic phonons propagating in bulk materials in turns. The properties of the dispersion relations and their phonon modes are also analyzed in depth based on the cut-off conditions. By the changing of Al components x and y, the bottom of these groups will be modified to adjust eigen frequencies of AlxGa1-xN or Al1-yGayN layers. But the propagation properties of acoustic phonon modes will remain unchanged in each section.

  20. 40 CFR 721.9527 - Bis(1,2,2,6,6-pentamethyl-4-piperidin-4-ol) ester of cy-clo-ali-phatic spiroketal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... processing/use workers only, requirements as specified in § 721.63(a)(4), (a)(5)(iv), (a)(5)(v), (a)(5)(vi... paragraph: This substance may cause systemic effects, eye irritation. (iii) Industrial, commercial,...

  1. JGME-ALiEM Hot Topics in Medical Education Online Journal Club: An Analysis of a Virtual Discussion About Resident Teachers

    PubMed Central

    Sherbino, Jonathan; Joshi, Nikita; Lin, Michelle

    2015-01-01

    Background  In health professionals' education, senior learners play a key role in the teaching of junior colleagues. Objective  We describe an online discussion about residents as teachers to highlight the topic and the online journal club medium. Methods  In January 2015, the Journal of Graduate Medical Education (JGME) and the Academic Life in Emergency Medicine blog facilitated an open-access, online, weeklong journal club on the JGME article “What Makes a Great Resident Teacher? A Multicenter Survey of Medical Students Attending an Internal Medicine Conference.” Social media platforms used to promote asynchronous discussions included a blog, a video discussion via Google Hangouts on Air, and Twitter. We performed a thematic analysis of the discussion. Web analytics were captured as a measure of impact. Results  The blog post garnered 1324 page views from 372 cities in 42 countries. Twitter was used to endorse discussion points, while blog comments provided opinions or responded to an issue. The discussion focused on why resident feedback was devalued by medical students. Proposed explanations included feedback not being labeled as such, the process of giving delivery, the source of feedback, discrepancies with self-assessment, and threats to medical student self-image. The blog post resulted in a crowd-sourced repository of resident teacher resources. Conclusions  An online journal club provides a novel discussion forum across multiple social media platforms to engage authors, content experts, and the education community. Crowd-sourced analysis of the resident teacher role suggests that resident feedback to medical students is important, and barriers to student acceptance of feedback can be overcome. PMID:26457152

  2. Development of Chromatographic Fingerprints of Eurycoma longifolia (Tongkat Ali) Roots Using Online Solid Phase Extraction-Liquid Chromatography (SPE-LC).

    PubMed

    Zaini, Nor Nasriah; Osman, Rozita; Juahir, Hafizan; Saim, Norashikin

    2016-04-30

    E. longifolia is attracting interest due to its pharmacological properties and pro-vitality effects. In this study, an online SPE-LC approach using polystyrene divinyl benzene (PSDVB) and C18 columns was developed in obtaining chromatographic fingerprints of E. longifolia. E. longifolia root samples were extracted using pressurized liquid extraction (PLE) technique prior to online SPE-LC. The effects of mobile phase compositions and column switching time on the chromatographic fingerprint were optimized. Validation of the developed method was studied based on eurycomanone. Linearity was in the range of 5 to 50 µg∙mL(-1) (r² = 0.997) with 3.2% relative standard deviation of peak area. The developed method was used to analyze 14 E. longifolia root samples and 10 products (capsules). Selected chemometric techniques: cluster analysis (CA), discriminant analysis (DA), and principal component analysis (PCA) were applied to the fingerprint datasets of 37 selected peaks to evaluate the ability of the chromatographic fingerprint in classifying quality of E. longifolia. Three groups were obtained using CA. DA yielded 100% correlation coefficient with 19 discriminant compounds. Using PCA, E. longifolia root samples were clearly discriminated from the products. This study showed that the developed online SPE-LC method was able to provide comprehensive evaluation of E. longifolia samples for quality control purposes.

  3. 78 FR 8181 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... Docket No. FEMA-B-1281, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and....Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management... Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a). These proposed flood...

  4. 78 FR 20341 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Docket No. FEMA-B-1303, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and....Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management... the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a). These proposed...

  5. 78 FR 20343 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Docket No. FEMA-B-1304, to Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and....Rodriguez3@fema.dhs.gov . FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management... Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a). These proposed flood...

  6. Science, science education and their discontents: a response to commentaries on the paper, Portrait of a Science Teacher as a Bricoleur: A case study from India

    NASA Astrophysics Data System (ADS)

    Sharma, Ajay

    2008-12-01

    In this response to commentaries by Ali Sammel, Jhumki Basu and Alberto Rodriguez, I present my perspective on three important issues raised by the commentators. These issues relate to the role of a researcher in her field settings and society, the critique of science and science education as oppressive dominant discourses, and co-opting participants as researchers. I argue that researchers should work actively for progressive change in discursive fields such as educational research, in which they are firmly embedded rather than playing an interventionist role in field settings where their discursive positionality maybe temporary and not that rooted. Regarding the critique of science and science education, my response favors a perspective wherein an understanding of the marginalization and oppression of non-western communities caused by western science and science education is counterbalanced by an appreciation of the ways in which marginalized communities can use science and science education for affecting progressive change. Lastly, I recognize the value of co-opting participants in writing and communication of research. [Figure not available: see fulltext.

  7. Supreme Court of the United States Syllabus: San Antonio Independent School District Et. Al. v. Rodriguez Et. Al. Appeal from the United States District Court for the Western District of Texas. No. 71-1332, Argued October 12, 1972 -- Decided March 21, 1973.

    ERIC Educational Resources Information Center

    Supreme Court of the U. S., Washington, DC.

    In this landmark educational finance opinion (presented here in full) the U.S. Supreme Court held that the Texas case was not a proper case in which to examine a State's laws under standards of strict judicial scrutiny. That test, according to the Court, is reserved for cases involving laws that operate to the disadvantage of suspect classes or…

  8. Effects of low environmental salinity on the cellular profiles and expression of Na+, K+-ATPase and Na+, K+, 2Cl- cotransporter 1 of branchial mitochondrion-rich cells in the juvenile marine fish Monodactylus argenteus.

    PubMed

    Kang, Chao-Kai; Liu, Fu-Chen; Chang, Wen-Been; Lee, Tsung-Han

    2012-06-01

    The goal of this study was to determine the osmoregulatory ability of a juvenile marine fish, silver moony (Monodactylus argenteus), for the purpose of developing a new experimental species for ecophysiological research. In this study, M. argenteus was acclimated to freshwater (FW), brackish water (BW), or seawater (SW). The salinity tolerance of this euryhaline species was effective, and the fish survived well upon osmotic challenges. The largest apical surface of mitochondrion-rich cells was found in the FW individuals. Immunohistochemical staining revealed that Na(+), K(+)-ATPase immunoreactive (NKA-IR) cells were distributed in the interlamellar region of the gill filaments of the silver moony in all experimental groups. In addition to the filaments, NKA-IR cells were also found in the lamellae of the FW individuals. The number of NKA-IR cells in the gills of the FW individuals exceeded that of the BW and SW individuals. The NKA-IR cells of FW and SW individuals exhibited bigger size than that of BW fish. The NKA activities and protein expression of the NKA α-subunit in the gills of the FW individuals were significantly higher than in the BW and SW groups. Additionally, the relative amounts of Na(+), K(+), 2Cl(-) cotransporter 1 (NKCC1) were salinity-dependent in the gills. Immunofluorescent signals of NKCC1 were localized to the basolateral membrane of NKA-IR cells in all groups. In the gills of the FW individuals, however, some NKA-IR cells did not exhibit a basolateral NKCC1 signal. In conclusion, the present study illustrated the osmoregulatory mechanisms of this easy- and economic-to-rear marine teleost with euryhaline capacity and proved the silver moony to be a good experimental animal.

  9. 75 FR 36782 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ...) (individual) 2. MONDRAGON DE RODRIGUEZ, Mariela, c/o MARIELA DE RODRIGUEZ Y CIA. S. EN C., Cali, Colombia; c/o.../o INVERSIONES MONDRAGON Y CIA. S.C.S., Cali, Colombia; c/o MARIELA MONDRAGON DE R. Y CIA. S. EN C... Y CIA. LTDA., Cali, Colombia; c/o M. RODRIGUEZ O. Y CIA. S. EN C., Cali, Colombia; c/o...

  10. 78 FR 44577 - Senior Executive Service Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... Grade, Deborah C. Gramlick, Carl Graves, Margaret Greene, Jonathan Griffin, Robert Grimm, Michael Gross..., David M. Robinson, George A. Roche, William W. Rodriguez, Waldemar Rogers, Debra Rudolph, Alan...

  11. 78 FR 36098 - Final Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... 13132. Executive Order 12988, Civil Justice Reform. This final rule meets the applicable standards...

  12. 77 FR 76915 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal... 13132, Federalism. Executive Order 12988, Civil Justice Reform. This final rule meets the...

  13. 77 FR 423 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal... 13132, Federalism. Executive Order 12988, Civil Justice Reform. This final rule meets the...

  14. 78 FR 32679 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  15. 78 FR 14316 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  16. 78 FR 36216 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  17. 78 FR 36220 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  18. 78 FR 14318 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  19. 78 FR 20337 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection...

  20. An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.

    PubMed

    Zhong, Huailing; Hansen, Kasper B; Boyle, Noel J; Han, Kiho; Muske, Galina; Huang, Xinyan; Egebjerg, Jan; Sánchez, Connie

    2009-10-25

    The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the interaction of these two compounds at a low affinity allosteric binding site of hSERT can affect the dissociation of [(3)H]escitalopram from hSERT. The allosteric binding site involves a series of residues in the 10th, 11th, and 12th trans-membrane domains of hSERT. The low affinity allosteric activities of escitalopram and R-citalopram are essentially eliminated in a mutant hSERT with changes in some of these residues, namely A505V, L506F, I507L, S574T, I575T, as measured in dissociation binding studies. We confirm that in association binding experiments, R-citalopram at clinically relevant concentrations reduces the association rate of [(3)H]escitalopram as a ligand to wild type hSERT. We demonstrate that the ability of R-citalopram to reduce the association rate of escitalopram is also abolished in the mutant hSERT (A505V, L506F, I507L, S574T, I575T), along with the expected disruption the low affinity allosteric function on dissociation binding. This suggests that the allosteric binding site mediates both the low affinity and higher affinity interactions between R-citalopram, escitalopram, and hSERT. Our data add an additional structural basis for the different efficacies of escitalopram compared to racemic citalopram reported in animal studies and clinical trials, and substantiate the hypothesis that hSERT has complex allosteric mechanisms underlying the unexplained in vivo activities of its inhibitors.

  1. Analyses par diffraction de rayons X sur des revêtements barrières thermiques réalisés par un procédé hybride plasma-laser

    NASA Astrophysics Data System (ADS)

    Antou, G.; Hlawka, F.; Montavon, G.; Bach, M.; Cornet, A.; Coddet, C.

    2004-11-01

    Les revêtements barrières thermiques (BTs) constitués de zircone yttriée partiellement stabilisée (ZrO{2} + 7% en masse d'Y{2}O{3}) et d'une sous-couche métallique (MCrAlY où M représente une combinaison de nickel et de cobalt) sont extrêmement utilisés afin d'améliorer les performances des composants des parties chaudes des turbines à gaz. La projection plasma sous atmosphère ambiante et l'irradiation laser in situ (au moyen d'un laser à diodes) sont associés ici afin de modifier les caractéristiques structurales des BTs. Les phases présentes au sein de la BT ont un rôle important. Des analyses par diffraction de rayons X ont été menées pour étudier les changements de phase possibles après traitement laser. Aucun changement de phase n'a été remarqué : la phase tétragonale métastable (t') demeure la phase prépondérante aussi bien pour les dépôts projetés que les dépôts post-traités au laser et refondus in situ. La formation de cette phase semble être liée à la solidification et au refroidissement rapide découlant de la projection plasma ainsi que de la refusion laser. Ce résultat est prometteur, car :

  2. Double stars measurements with cheap CCD sensors (French Title: Mesures d'étoiles doubles visuelles réalisées à l'aide de capteurs dtc de grande diffusion)

    NASA Astrophysics Data System (ADS)

    Losse, F.

    2005-09-01

    This paper presents 262 measurements of visual binaries. They essentially come from a three years evaluation period of cheap CCD sensors coupled with either off the shelves or modified webcam electronics. The evaluation cycle and results are largely described in Bulletin n°40 de la Commission des Etoiles Doubles (Sept. 2002 - Société Astronomique de France). These devices can produce measurements as consistent as those obtained with a filar micrometer on the same 8" telescope. The most recent measurements (epoch 2004+) were obtained with an "Audine" camera shipped with a KAF400. Besides the stars visited for evaluation purpose, we present some systems of interest : 17 orbital binaries, 35 neglected systems, 15 confirmations and 2 discoveries of a third component in already known systems.

  3. On the crystal energy and structure of A{sub 2}Ti{sub n}O{sub 2n+1} (A=Li, Na, K) titanates by DFT calculations and neutron diffraction

    SciTech Connect

    Catti, Michele; Pinus, Ilya; Scherillo, Antonella

    2013-09-15

    First-principles quantum-mechanical calculations (CRYSTAL09 code, B3LYP functional) were performed on alkali titanates A{sub 2}Ti{sub n}O{sub 2n+1} with layered structure (n=3,4,6). Monoclinic structural types with unshifted (P2{sub 1}/m) and with shifted (C2/m) layers were considered. Crystal energies and full structural details were obtained for all Li, Na, and K phases. Neutron diffraction data were collected on powder samples of P2{sub 1}/m-Li{sub 2}Ti{sub 3}O{sub 7} (a=9.3146(3), b=3.7522(1), c=7.5447(3) Å, β=97.611(4)°) and C2/m-K{sub 2}Ti{sub 4}O{sub 9} (a=18.2578(8), b=3.79160(9), c=12.0242(4) Å, β=106.459(4)°) and their structures were Rietveld-refined. Computed energies show the P2{sub 1}/m arrangement as favoured over the C2/m one for n=3, and the opposite holds for n=6. In the n=4 case the P2{sub 1}/m configuration is predicted to be more stable for Li and Na, and the C2/m one for K titanates. Analysis of Li–O and K–O crystal-chemical environments from experiment and theory shows that the alkali atom bonding is stabilized/destabilized in the different phases consistently with the energy trend. - Graphical abstract: Display Omitted - Highlights: • The P2{sub 1}/m structure-type is found to be more stable for A{sub 2}Ti{sub 3}O{sub 7} layer titanates. • The C2/m structure-type is found to be more stable for A{sub 2}Ti{sub 6}O{sub 13} layer titanates. • Tetratitanates are predicted to prefer the P2{sub 1}/m (Li and Na) or C2/m (K) structure. • Li–O and K–O bond distances follow a trend consistent with computed phase energies.

  4. 78 FR 36635 - Additional Designations, Foreign Narcotics Kingpin Designation Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... Lomas Altas, Zapopan, Jalisco, Mexico; Av. Pablo Neruda No. 4111, Casa 1, Colonia Lomas del Valle..., Av. Vallarta No. 3060, Colonia Vallarta San Jorge, Guadalajara, Jalisco, Mexico; DOB 03 Mar 1971; POB.... DE C.V.). 10. GARZA RODRIGUEZ, Beatriz (a.k.a. GARZA RODRIGUEZ DE SANCHEZ, Beatriz), Av. Vallarta...

  5. 76 FR 20606 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ..., identified by Docket No. FEMA-B-1188, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988....

  6. 76 FR 36044 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ..., identified by Docket No. FEMA-B-1197, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988....

  7. 75 FR 75949 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ..., identified by Docket No. FEMA-B-1161, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988....

  8. A Historian Will Lead a Community College in the Bronx

    ERIC Educational Resources Information Center

    Mangan, Katherine

    2009-01-01

    In July 2009, Felix V. Matos Rodriguez will take over as president of Hostos Community College of the City University of New York, which in 1970 opened in a converted tire factory in the South Bronx to educate members of a primarily Puerto Rican community. Like Mr. Matos Rodriguez, who moved to the mainland United States at age 18, many of those…

  9. 76 FR 26978 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ..., identified by Docket No. FEMA-B-1190, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., Civil Justice Reform. This proposed rule meets the applicable standards of Executive Order 12988....

  10. Validation of Biomarkers of the Tumor Microenvironment

    DTIC Science & Technology

    2014-10-01

    A., Yao , H., Rahmatpanah, F., Xia, X. Q., Xu, Q., Pio, R., Turan, T., Koziol, J. A., Goodison, S., Carpenter, P., Wang-Rodriguez, J., Simoneau, A...Wang, Y., Skarecky, D., Sutton, M., Sawyers, A., Ruckle, H., Carpenter, P. M., Wang-Rodriguez, J., Jiang, J., Deng, M., Pan , C., Zhu, J. G., McLaren, C

  11. DoD Resource Augmentation for Civilian Consequence Management (DRACCM) Tool

    DTIC Science & Technology

    2015-07-01

    from the 1917 Camp Custer influenza outbreak (Bombardt & Brown, 2003) ( Bloom & Rodriguez, June 2004). The output of the quick calculator is a Microsoft...models, and user testing and feedback. 23 6.0 REFERENCES Bloom , R., & Rodriguez, J. (June 2004). Linkage Between Primary Case Scenarios and SEIR

  12. Role of Protein Synthesis Initiation Factors in Dietary Soy Isoflavone-Mediated Effects on Breast Cancer Progression

    DTIC Science & Technology

    2012-03-01

    Kit (Qiagen, Valencia , CA). RNA concentration was detected using a NanoDrop (Thermo Scientific, Wilmington, DE). RNA (0.5 g) was used to synthesize...Bandera EV, King M, Chandran U, Paddock LE, Rodriguez - Rodriguez L, Olson SH. Phytoestrogen consumption from foods and supplements and epithelial

  13. Answers to Inequity: An Analysis of the New School Finance.

    ERIC Educational Resources Information Center

    Berke, Joel S.

    This study of the fiscal, legal, and political dimensions of reform in American school finance responds to the challenge of San Antonio Independent School District vs. Rodriguez. The book focuses specifically on the State of Texas and the way in which injustices were analyzed for the landmark Rodriguez case. The book goes on to describe the role…

  14. Texas Public School Finance: Resolving the Issue. A Report.

    ERIC Educational Resources Information Center

    Spurgin, N. David

    Published prior to the U.S. Supreme Court decision on the case, this report puts into perspective the questions and problems before the State of Texas in resolving the issue raised by Rodriguez vs San Antonio. The document reviews the key elements of the decision in the Rodriguez case and considers alternative approaches that comply with the…

  15. 78 FR 37785 - Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Gerardo Domingo... Domingo Rodriguez-Rivera (``Rodriguez-Rivera'') was convicted of violating Section 38 of the ] Arms Export... convicted of knowingly and willfully exporting and causing to be exported and attempting to export...

  16. How Could It Be? Calling for Science Curricula That Cultivate Morals and Values towards Other Animals and Nature

    ERIC Educational Resources Information Center

    Logan, Marianne R.; Russell, Joshua J.

    2016-01-01

    Can science curricula truly cultivate morals and values towards nature? This is the question that is raised by Carolina Castano Rodriguez in her critique of the new Australian Science curriculum. In this response to Castano Rodriguez's paper we ask two questions relating to: the influence of curricula on the relationships of children and other…

  17. Pakistan’s Domestic Political Developments

    DTIC Science & Technology

    2005-09-19

    two parliamentary seats in the 1993 and 1997 elections). Notable Leaders of Pakistan Governor-General Mohammed Ali Jinnah 1947-1948 Prime Minister...Nation) Muhammed Ali Jinnah and his lieutenant, Liaquat Ali Khan, the PML was weakened upon their premature deaths in 1948 and 1951 ( Jinnah by natural...Liaquat Ali Khan 1947-1951 President Iskandar Ali Mirza 1955-1958 President-General Mohammed Ayub Khan 1958-1969 President-General Mohammed Yahya Khan

  18. Piezoelectric and electrostrictive materials for transducers applications, volume 1

    NASA Astrophysics Data System (ADS)

    Cross, L. E.; Newnham, R. E.; Bhalla, A. S.; Dougherty, J. P.; Adair, J. H.; Varadan, V. K.; Varadan, V. V.

    1992-01-01

    Highlights of the past year's activities include: An increased emphasis upon the flextensional (moonie) type actuators, modeling both the internal stress distribution as a function of geometry, and the very interesting resonant mode structure of the composites; a more refined focus upon the performance of piezoelectric ceramic transducers, particularly under high drive levels is developing with concern for the extrinsic domain and phase boundary contributions to response. Measurement and modelling are being used to explore the nonlinearity and the frequency response and to examine the phase partitioning at the rhombohedral:tetragonal morphotropic phase boundary in the PZT system. Phenomena limiting lifetime in polarization and phase switching actuators are being explored to separate surface and volume effects and those due to grain size and flaw population differences. New work has been initiated to examine Acoustic Emission as a technique, in combination with Barkhausen current pulse analysis, to separate and evaluate domain switching and microcracking in polarization switching systems.

  19. 78 FR 32673 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...). City of Santa Valencia 060729-102DA.pdf. Clarita, 23920 Boulevard, Santa Valencia Clarita, CA...

  20. 76 FR 62329 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    .... Mean Sea Level, rounded to the nearest 0.1 meter. * * BFEs to be changed include the listed downstream...) for exact locations of all BFEs to be changed. Send comments to Luis Rodriguez, Chief,...

  1. 78 FR 35305 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... lomrs.htm. 3911P). East San Antonio Department, 1251 Street, Suite Civic Center 300, San Marcos,...

  2. 78 FR 28887 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., 10th Floor, San 420, San Antonio, Antonio, TX 78205. TX 78207. ] Collin (FEMA Docket No.: B- City...

  3. Rodriquez and Friends

    ERIC Educational Resources Information Center

    Mathews, Linda

    1973-01-01

    Recounts the now-famous Supreme Court case, San Antonio Independent School District versus Rodriguez, relating to the proposition that wealth-based inequities in school spending are unconstitutional. (RJ)

  4. 78 FR 34116 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., 10th Floor, San Suite 420, San Antonio, TX 78205. Antonio, TX 78207. Harris (FEMA Docket No.:...

  5. 78 FR 56993 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ...); Gary D. Hallman (AL); Edward J. Kasper (DE); Jorge Lopez (OH); Robert D. Porter (CA); Robert A. Reyna.... Raymond (FL); J. Bernardo Rodriguez (TX); Lee T. Taylor (FL). The exemptions are extended subject to...

  6. 78 FR 37850 - Quality Assurance Program Requirements (Operations)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... Rodriguez-Luccioni Regulatory Guide Development Branch, Division of Engineering, Office of Nuclear..., Chief, Regulatory Guide Development Branch, Division of Engineering, Office of Nuclear Regulatory... From the Federal Register Online via the Government Publishing Office NUCLEAR...

  7. 76 FR 44462 - Statement of General Policy or Interpretation; Commentary on the Fair Credit Reporting Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... assist consumers and businesses in combating identity theft and reducing the damage to consumers when... INFORMATION CONTACT: Anthony Rodriguez, (202) 326-2757, Division of Privacy and Identity Protection, Bureau...

  8. 75 FR 81889 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... modifications are made pursuant to section 201 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4105,...

  9. 77 FR 56669 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ..., Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500 C Street SW... CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... for each community listed below, in accordance with section 110 of the Flood Disaster Protection...

  10. The Real Issue: Need for Tax Reform

    ERIC Educational Resources Information Center

    Hall, David

    1973-01-01

    The Rodriguez decision simply points up the fact that the answer to unequal educational opportunity is not to be found in the federal constitution but in the reform of property assessment and property taxation. (Author/JN)

  11. 78 FR 32701 - Hours of Service of Drivers: Trailways Companies Application for Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... picking up or discharging passengers, baggage and/or package express items.'' Ms. Veronica Rodriguez said... license plate number, e. Number of individuals suffering physical injury, f. Number of fatalities, g....

  12. Bionomics of the Primary Malaria Vector, Anopheles pseudopunctipennis, in the Tapachula Foothill Area of Southern Mexico

    DTIC Science & Technology

    1992-02-04

    of Preventive Medicine and Biometrics. and Mario Henry Rodriguez, Adjunct Associate Professor Malaria, the more important vector-borne disease in...and guidance provided by Dr. Mario Henry Rodriguez. I am very grateful for the opportunity to have worked with him in TapachuIa, Mexico. The...Mexico ( Vargas and Martinez-Palacios, 1955). Included in the list of actual and potential malaria vectors is Anopheles albimanus Wiedemann, An

  13. High-Temperature Transitions in Metallopolymers Crosslinked With 2,6-bis(1’-methylbenzimidazolyl)pyridine Metal-Ligand Complex

    DTIC Science & Technology

    2013-10-01

    C . Jackson, Robert H . Lambeth, Victor Rodriguez-Santiago, Brady G. Butler, and Frederick L. Beyer ARL-TR-6706 October 2013...Temperature Transitions in Metallopolymers Crosslinked With 2,6-bis(1’-methylbenzimidazolyl)pyridine Metal-Ligand Complex Aaron C . Jackson, Robert H ...5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Aaron C . Jackson, Robert H . Lambeth, Victor Rodriguez-Santiago

  14. Solubility of RDX, PETN and Boric Acid in Methylene Chloride

    DTIC Science & Technology

    2010-08-01

    Solubility of RDX, PETN, and Boric Acid in Methylene Chloride by Rose Pesce-Rodriguez ARL-TN-0401 August 2010...of RDX, PETN, and Boric Acid in Methylene Chloride Rose Pesce-Rodriguez Weapons and Materials Research Directorate, ARL...AND SUBTITLE Solubility of RDX, PETN and Boric Acid in Methylene Chloride 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  15. A new species and new records of Cryptodacus (Diptera: Tephritidae) from Colombia, Bolivia and Peru.

    PubMed

    Rodriguez, Pedro Alexander; Rodriguez, Erick J; Norrbom, Allen L; Arévalo, Emilio

    2016-05-16

    Cryptodacus bernardoi Rodriguez & Rodriguez, new species, is described from Colombia. It was reared from fruits of Phoradendron sp. near piperoides (Kunth) Trel. New distribution records are reported for Cryptodacus ornatus Norrbom from Colombia and Peru, for Cryptodacus trinotatus Norrbom & Korytkowski from Colombia, and for Cryptodacus obliquus Hendel from Bolivia and Peru. The female abdomen and terminalia of C. obliquus is described for the first time. The Norrbom & Korytkowski (2008)`s key to species was modified to include C. bernardoi n. sp.

  16. Neoplasms of the Stomach, Liver & Pancreas: Prevention, Diagnosis, and Treatment among High-Risk Populations | Division of Cancer Prevention

    Cancer.gov

    Agenda - Day 1, September 18, 2015 08:00 am - Registration 08:30 am - Welcome remarks and overview of the Conference Dr. Leslie Ford (NCI) – 5 min Dr. Edgar Colon (RCM and UPRCCC) - 5 min Luz Maria Rodriguez – Conference objectives & structure  Global Cancer Burden: An Overview and State of the Problem Moderators: Dr. Luz Maria Rodriguez and Dr. Victor Jose Carlo (PR Gastroenterology Association) |

  17. Characterization of Cyclohexanone Inclusions in Class 1 RDX

    DTIC Science & Technology

    2014-06-01

    Characterization of Cyclohexanone Inclusions in Class 1 RDX by Rose A. Pesce-Rodriguez and Stephanie M. Piraino ARL-TR-6962 June 2014...TR-6962 June 2014 Characterization of Cyclohexanone Inclusions in Class 1 RDX Rose A. Pesce-Rodriguez and Stephanie M. Piraino Weapons...3. DATES COVERED (From - To) 12/2012 to 6/2013 4. TITLE AND SUBTITLE Characterization of Cyclohexanone Inclusions in Class 1 RDX 5a. CONTRACT

  18. JPRS Report Science & Technology Europe Twenty-Fourth Isata International Symposium on Automotive Technology and Automation.

    DTIC Science & Technology

    1991-09-05

    34 P de Miguel , A Perez, C Gascon, S Rodriguez and F Guardia, Universidad Politecnica de Madrid, Spain 639 645 653 659 667 675 679 687 695...703 711 Stream B 910107 "Image Processing Sensors for Driver Behaviour Characterization" P 719 de Miguel , L Pastor and A Rodriguez...Thyssen Stahl AG, FRG "Microalloyed Steels for Forging. Optimization of Process Parameters" J M 87 Prado, A Herrero and .1 M Cabrera , Universidad

  19. Theoretical/Computational Studies of High-Temperature Superconductivity from Quantum Magnetism

    DTIC Science & Technology

    2016-06-09

    Rodriguez1 1Department of Physics and Astronomy , California State University, Los Angeles, California 90032 Abstract The symmetry of a single Cooper pair in...2014. 7. J.P. Rodriguez, “Collective Modes in Iron Superconductors from the Local Moment Limit” (invited talk), Department of Physics and Astronomy ...Are the New Class of Iron-Pnictide Superconductors Doped Mott Insulators?” (invited talk), Department of Physics and Astronomy , California State

  20. Adaptive Gravitational Gossip in Monitoring the Joint Battlespace Infosphere

    DTIC Science & Technology

    2007-03-01

    GWCast by Hopkinson et al [3]. A project that is analogous to JBI efforts is the Network-friendly Epidemic Mul- ticast ( NEEM ) project, also by Rodriguez...21]. NEEM focuses on preserving bandwidth and keeping costs down on transmissions. These two qualities are what military commu- nicators are seeking...nodes or agents in the network medium chosen; one such example is using gossip in a WAN environment as tested by Rodriguez with NEEM [21]. With the

  1. Studies of Prostate Tumor Development via Cre/LoxP Technology

    DTIC Science & Technology

    2002-05-01

    in our facility and used routinely in our transgenic experiments (Robles et al., 1996; Rodriguez Puebla et al., 2000). Crosses with Rosa 26 mice have...In the case of K5-Cre we used the strategy used routinely in our laboratory with primers for the Globin intron (Rodriguez Puebla et al. 2000). In the... Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM. Metastatic prostate cancer in a transgenic mouse. Cancer

  2. Bronchoscopy-Derived Correlates of Lung Injury Following Inhalational Injuries: A Prospective Obervational Study

    EPA Science Inventory

    Acute lung injury (ALI) is a major factor determining morbidity following burns and inhalational injury. In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studi...

  3. Alginate lyases from alginate-degrading Vibrio splendidus 12B01 are endolytic.

    PubMed

    Badur, Ahmet H; Jagtap, Sujit Sadashiv; Yalamanchili, Geethika; Lee, Jung-Kul; Zhao, Huimin; Rao, Christopher V

    2015-03-01

    Alginate lyases are enzymes that degrade alginate through β-elimination of the glycosidic bond into smaller oligomers. We investigated the alginate lyases from Vibrio splendidus 12B01, a marine bacterioplankton species that can grow on alginate as its sole carbon source. We identified, purified, and characterized four polysaccharide lyase family 7 alginates lyases, AlyA, AlyB, AlyD, and AlyE, from V. splendidus 12B01. The four lyases were found to have optimal activity between pH 7.5 and 8.5 and at 20 to 25°C, consistent with their use in a marine environment. AlyA, AlyB, AlyD, and AlyE were found to exhibit a turnover number (kcat) for alginate of 0.60 ± 0.02 s(-1), 3.7 ± 0.3 s(-1), 4.5 ± 0.5 s(-1), and 7.1 ± 0.2 s(-1), respectively. The Km values of AlyA, AlyB, AlyD, and AlyE toward alginate were 36 ± 7 μM, 22 ± 5 μM, 60 ± 2 μM, and 123 ± 6 μM, respectively. AlyA and AlyB were found principally to cleave the β-1,4 bonds between β-d-mannuronate and α-l-guluronate and subunits; AlyD and AlyE were found to principally cleave the α-1,4 bonds involving α-l-guluronate subunits. The four alginate lyases degrade alginate into longer chains of oligomers.

  4. Alginate Lyases from Alginate-Degrading Vibrio splendidus 12B01 Are Endolytic

    PubMed Central

    Badur, Ahmet H.; Jagtap, Sujit Sadashiv; Yalamanchili, Geethika; Lee, Jung-Kul; Zhao, Huimin

    2015-01-01

    Alginate lyases are enzymes that degrade alginate through β-elimination of the glycosidic bond into smaller oligomers. We investigated the alginate lyases from Vibrio splendidus 12B01, a marine bacterioplankton species that can grow on alginate as its sole carbon source. We identified, purified, and characterized four polysaccharide lyase family 7 alginates lyases, AlyA, AlyB, AlyD, and AlyE, from V. splendidus 12B01. The four lyases were found to have optimal activity between pH 7.5 and 8.5 and at 20 to 25°C, consistent with their use in a marine environment. AlyA, AlyB, AlyD, and AlyE were found to exhibit a turnover number (kcat) for alginate of 0.60 ± 0.02 s−1, 3.7 ± 0.3 s−1, 4.5 ± 0.5 s−1, and 7.1 ± 0.2 s−1, respectively. The Km values of AlyA, AlyB, AlyD, and AlyE toward alginate were 36 ± 7 μM, 22 ± 5 μM, 60 ± 2 μM, and 123 ± 6 μM, respectively. AlyA and AlyB were found principally to cleave the β-1,4 bonds between β-d-mannuronate and α-l-guluronate and subunits; AlyD and AlyE were found to principally cleave the α-1,4 bonds involving α-l-guluronate subunits. The four alginate lyases degrade alginate into longer chains of oligomers. PMID:25556193

  5. International Game 󈨧: Crisis in South Asia, 28-30 January 1999

    DTIC Science & Technology

    1999-01-01

    September 11) Mohammed Ali Jinnah dies. Liaquat Ali Khan becomes Governor General of Pakistan. India Department of Atomic Energy created. 1950... Ali Jinnah becomes leader of Muslim League. 1935 British pass “Government of India Act of 1935” expanding power of elected national and provincial... Mohammed Ali Bogra becomes leader of Pakistan. 1954 India signs friendship treaty with China. 1955 Pakistan Atomic Energy Commission set up to

  6. Pakistan’s Search for Identity

    DTIC Science & Technology

    1966-04-08

    suffered greatly as a result. There was no legislature but only a political party, the Muslim League, with Mohammed Ali Jinnah as its leader. He...the leadership of Mohandas K. Gandhi, and the Muslim League with its leader, Mohammad Ali Jinnah , did agree on the desirability of independence but... Ali Jinnah , and then the assassination in 1951 of the prime minister, Liaquat Ali Khan, left no nationally recognized leader. The country’s major

  7. Beyond Standards

    ERIC Educational Resources Information Center

    Sherlock, David

    2007-01-01

    In this article, the author reflects on his stay at Adult Learning Inspectorate (ALI) and on his life after it. ALI was not just a piece of the state bureaucracy, what some civil servants ironically insisted on describing as the "burden on providers." ALI had been a long time in the making and rested on some very solidly established ideas about…

  8. Standing Watch

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    Russlynn Ali, Assistant Secretary for Civil Rights at the Department of Education, is charged with enforcing a wide range of education equity laws. Ali was a passionate activist in California helping champion educational equity for minorities. Today, as Ali approaches her third year working as assistant secretary for civil rights, she says she has…

  9. Family 13 carbohydrate-binding module of alginate lyase from Agarivorans sp. L11 enhances its catalytic efficiency and thermostability, and alters its substrate preference and product distribution.

    PubMed

    Li, Shangyong; Yang, Xuemei; Bao, Mengmeng; Wu, Ying; Yu, Wengong; Han, Feng

    2015-05-01

    The carbohydrate-binding module (CBM) in polysaccharide hydrolases plays a key role in the hydrolysis of cellulose, xylan and chitin. However, the function of CBM in alginate lyases has not been elucidated. A new alginate lyase gene, alyL2, was cloned from the marine bacterium Agarivorans sp. L11 by using degenerate and site-finding PCR. The alginate lyase, AlyL2, contained an N-terminal CBM13 and a C-terminal catalytic family 7 polysaccharide lyase (PL7) module. To better understand the function of CBM13 in alginate lyase AlyL2, the full-length enzyme (AlyL2-FL) and its catalytic module (AlyL2-CM) were expressed in Escherichia coli and characterized. The specific activity and catalytic efficiency of AlyL2-FL were approximately twice those of AlyL2-CM. The half-lives of AlyL2-FL were 4.7-6.6 times those of AlyL2-CM at 30-50°C. In addition, the presence of CBM13 in AlyL2 changed its substrate preference and increased the percentage of disaccharides from 50.5% to 64.6% in the total products. This first report of the function of CBM13 in alginate lyase provides new insights into the degradation of alginate by marine microorganisms.

  10. Tailored plasma sprayed MCrAlY coatings for aircraft gas turbine applications

    NASA Technical Reports Server (NTRS)

    Pennisi, F. J.; Gupta, D. K.

    1981-01-01

    Eighteen plasma sprayed coating systems, nine based on the NiCoCrAly chemistry and nine based on the CoCrAly composition, were evaluated to identify coating systems which provide equivalent or superior life to that shown by the electron beam physical vapor deposited NiCoCrAly and CoCrAly coatings respectively. NiCoCrAly type coatings were examined on a single crystal alloy and the CoCrAly based coatings were optimized on the B1900+ Hf alloy. Cyclic burner rig oxidation and hot corrosion and tensile ductility tests used to evaluate the various coating candidates. For the single crystal alloy, a low pressure chamber plasma sprayed NiCoCrAly + Si coating exhibited a 2x oxidation life improvement at 1394 K (2050 F) over the vapor deposited NiCoCrAly material while showing equivalent tensile ductility. A silicon modified low pressure chamber plasma sprayed CoCrAly coating was found to be more durable than the baseline vapor deposited CoCrAly coating on the B1900+ Hf alloy.

  11. Macrophage Migration Inhibitory Factor in Acute Lung Injury: Expression, Biomarker and Associations

    PubMed Central

    Gao, Li; Flores, Carlos; Ma, Shwu-Fan; Miller, Edmund J.; Moitra, Jaideep; Moreno, Liliana; Wadgaonkar, Raj; Simon, Brett; Brower, Roy; Sevransky, Jonathan; Tuder, Rubin M.; Maloney, James P.; Moss, Marc; Shanholtz, Carl; Yates, C. Ryan; Meduri, Gianfranco Umberto; Ye, Shui Q.; Barnes, Kathleen C.; Garcia, Joe G.N.

    2007-01-01

    Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine central to the response to endotoxemia, is a putative biomarker in acute lung injury (ALI). To explore MIF as a molecular target and candidate gene in ALI, we examined MIF gene and protein expression in murine and canine models of ALI (high tidal volume mechanical ventilation, endotoxin exposure) and in patients with either sepsis or sepsis-induced ALI. MIF gene expression and protein levels were significantly increased in each ALI model, with serum MIF levels significantly higher in patients with either sepsis or ALI compared to healthy controls (African- and European- descent). We next studied the association of 8 MIF gene polymorphisms (SNPs) (within a 9.7 kb interval on chromosome 22q11.23) with the development of sepsis and ALI in European- and African- descent populations. Genotyping in 506 DNA samples (sepsis patients, sepsis-associated ALI patients, and healthy controls) revealed haplotypes located in the 3′ end of the MIF gene, but not individual SNPs, associated with sepsis and ALI in both populations. These data, generated via functional genomic and genetic approaches, suggest that MIF is a relevant molecular target in ALI. PMID:17585860

  12. Protective effects of ethyl pyruvate on lipopolysaccharide-induced acute lung injury through inhibition of autophagy in neutrophils

    PubMed Central

    Zhu, Qingteng; Wang, Hui; Wang, Hairong; Luo, Yong; Yu, Yang; Du, Qirong; Fei, Aihua; Pan, Shuming

    2017-01-01

    Among a number of clinical factors, bacterial infection is one of the most common causes of acute lung injury (ALI), a serious complication that carries a high risk of mortality (~40%). During the process of ALI, intense local and systemic inflammation is elicited, which exacerbates the injury. Neutrophil infiltration into airspace is observed in early stage of ALI, and is required for the full development of ALI through an array of mechanisms, including the release of granule contents and the production of pro-inflammatory cytokines, due to the overactivation of complement and cytokines. The present study noted that ethyl pyruvate alleviated ALI in lipopolysaccharide (LPS)-induced ALI mice. Increased autophagy in neutrophils from ALI mice was observed, while ethyl pyruvate diminished autophagy in neutrophils and constrained granule release, and therefore myeloperoxidase (MPO) in bronchoalveolar lavage fluid and the production of proinflammatory cytokines. Using neutrophil cells, it was identified that autophagy was required for neutrophil activation and granule release, and that ethyl pyruvate caused neutrophil autophagy, leading to the restriction of granule release, and thus contributing to the mitigation of ALI. If autophagy was obviated through knockdown of key regulator of autophagy Atg5, the effects of ethyl pyruvate on granule release by neutrophils disappeared. Taken together, the results demonstrated that ethyl pyruvate alleviates ALI through inhibition of autophagy-induced granule release by neutrophils, and this mechanism suggested a novel potential therapeutic target in autophagy regulation for ALI. PMID:28098908

  13. Neurological outcome after experimental lung injury.

    PubMed

    Bickenbach, Johannes; Biener, Ingeborg; Czaplik, Michael; Nolte, Kay; Dembinski, Rolf; Marx, Gernot; Rossaint, Rolf; Fries, Michael

    2011-12-15

    We examined the influences of acute lung injury and hypoxia on neurological outcome. Functional performance was assessed using a neurocognitive test and a neurologic deficit score (NDS) five days before. On experimental day, mechanically ventilated pigs were randomized to hypoxia only (HO group, n=5) or to acute lung injury (ALI group, n=5). Hemodynamics, respiratory mechanics, systemic cytokines and further physiologic variables were obtained at baseline, at the time of ALI, 2, 4 and 8h thereafter. Subsequently, injured lungs were recruited and animals weaned from the ventilator. Neurocognitive testing was re-examined for five days. Then, brains were harvested for neurohistopathology. After the experiment, neurocognitive performance was significantly worsened and the NDS increased in the ALI group. Histopathology revealed no significant differences. Oxygenation was comparable between groups although significantly higher inspiratory pressures occured after ALI. Cytokines showed a trend towards higher levels after ALI. Neurocognitive compromise after ALI seems due to a more pronounced inflammatory response and complex mechanical ventilation.

  14. Role of NuSAP in Prostate Tumor Progression

    DTIC Science & Technology

    2012-06-01

    RNA extraction. DNA, RNA and microRNA were isolated from each tissue sample using Qiagen AllPrep DNA/RNA mini kit (Qiagen Inc., Valencia , CA, USA...prostate cancer. Nature 2002; 419: 624 - 629. 11 Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang- Rodriguez J, Moskaluk CA et al. Analysis of gene...cancer: which definition(s) to use? Breast Cancer Res 2011; 13: 105. 41 Rodriguez -Enriquez S, Pacheco-Velazquez SC, Gallardo-Perez JC, Marin-Hernandez A

  15. Research Directions in Database Security, II

    DTIC Science & Technology

    1990-11-01

    Hwy 791 OTTENBERG 24th St 857 PERKINS Yoakum St 980 POLANCO Hunter Rd 965 POLANKA Ripley Rd 753 PYLE Prince St 43 REYNOLDS Landess St 678 RODRIGUEZ...Mgt Anal PER MCALLISTER Adm Ast PER MYER Per Anal PER PERKINS Secy PER POLANCO Adm Ast PER REYNOLDS Per Anal PER SMALL Proj Mgr PER STROTHER Secy...MCINTOSH 35 MITCHELL 90 MYER 75 MYERSON 80 NAUROZ 35 OBERLY 80 OPEL 45 OTTENBERG 90 PERKINS 35 POLANCO 60 POLANKA 90 PYLE 80 REYNOLDS 75 RODRIGUEZ 80

  16. Hi Observations of the Supermassive Binary Black Hole System in 0402+379

    DTIC Science & Technology

    2009-05-20

    Printed in the U.S.A. H i OBSERVATIONS OF THE SUPERMASSIVE BINARY BLACK HOLE SYSTEM IN 0402+379 C. Rodriguez1, G. B. Taylor1,5, R. T. Zavala2, Y. M...April 30 ABSTRACT We have recently discovered a supermassive binary black hole system with a projected separation between the two black holes of 7.3 pc in...the radio galaxy 0402+379 (Rodriguez et al. 2006). This is the most compact supermassive binary black hole pair yet imaged by more than two orders of

  17. Scalar discrete nonlinear multipoint boundary value problems

    NASA Astrophysics Data System (ADS)

    Rodriguez, Jesus; Taylor, Padraic

    2007-06-01

    In this paper we provide sufficient conditions for the existence of solutions to scalar discrete nonlinear multipoint boundary value problems. By allowing more general boundary conditions and by imposing less restrictions on the nonlinearities, we obtain results that extend previous work in the area of discrete boundary value problems [Debra L. Etheridge, Jesus Rodriguez, Periodic solutions of nonlinear discrete-time systems, Appl. Anal. 62 (1996) 119-137; Debra L. Etheridge, Jesus Rodriguez, Scalar discrete nonlinear two-point boundary value problems, J. Difference Equ. Appl. 4 (1998) 127-144].

  18. Development of a PTSD Population Registry

    DTIC Science & Technology

    2009-09-01

    OUTCOMES   Keane, T.M., Rosen, R., Maserejian, N., Holowka, D.W., Rodriguez, P., Marx, B.P., Kang,  H., Vasterling, J.J. Wunderle, K.B.,  Rodier , N.A...Holowka, D.W., Rodriguez, P., Marx, B.P., Kang,  H., Vasterling, J.J. Wunderle, K.B.,  Rodier , N.A., Sloan D.S.,  Friedman, M.J., Sleeper, L.A.  (2009

  19. Development of a PTSD Population Registry

    DTIC Science & Technology

    2010-09-01

    Keane, T.M., Rosen, R., Maserejian, N., Holowka, D.W., Rodriguez, P., Marx, B.P., Kang, H., Vasterling, J.J. Wunderle, K.B., Rodier , N.A., Sloan D.S...Rodriguez, P., Marx, B.P., Kang, H., Vasterling, J.J. Wunderle, K.B., Rodier , N.A., Sloan D.S., Friedman, M.J., Sleeper, L.A. (2009). Creation of a PTSD...City, MO. Rosen, R.C., Keane, T.M., Marx, B.P., Maserejian, N.N., Holowka, D.W., Kang, H.K., Vasterling, J.J., Rodier , N.A., Sleeper, L.A. (2010

  20. Studies of Prostate Tumor Development via Cre/LoxP Technology

    DTIC Science & Technology

    2003-05-01

    used routinely in our transgenic experiments (Robles et al., 1996; Rodriguez Puebla et al., 2000). Crosses with Rosa 26 mice have already been...enzyme substrate for beta-galactosidase. Biol Chem Hoppe Seyler, 373(12):1187-91, Dec. 1992. Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ...Sci, 93:7634-7638, 1996. Rodriguez- Puebla , M.L., LaCava, M., Miliani de Marval, P.L., Jorcano, J.L., Richie, E.R. and Conti, C.J. Cyclin D2

  1. 76 FR 42024 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    .../A319/A320/A321 ALI Document reference AI/SE-M4/95A.0252/ 96 and Airbus A319 Corporate Jet ALI Document reference AI/SE-M2/ 95A.1038/99, which are approved by the European Aviation Safety Agency (EASA) and... specified in Airbus A318/A319/A320/A321 ALI Document reference AI/ SE-M4/95A.0252/96 issue 10 and...

  2. 75 FR 52246 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... (Airworthiness Limitations Section) part 2 under ALI Document reference AI/SE-M4/95A.0252/96 at issue 7; approved... A318/A319/A320/A321 Airworthiness Limitation Items (ALI) AI/SE-M4/95A.0252/96, Issue 09, dated November... 552007-01-1 or 552007-01-3, which is defined in Airbus A318/A319/A320/A321 ALI AI/...

  3. 76 FR 4260 - Airworthiness Directives; Airbus Model A300 and A310 Series Airplanes, and Model A300 B4-600, B4...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Service Information Airbus has issued A300-600 Airworthiness Limitation Items (ALI) Document AI/SE-M2/95A.1310/07, Issue 12, dated June 2008; A300 ALI Document AI/SE-M2/95A.1308/07, Issue 4, dated June 2008; and A310 ALI Document, AI/SE-M2/95A.1309/07, Issue 7, dated June 2008. The actions described in...

  4. 76 FR 16582 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... A318/A319/A320/ A321 Airworthiness Limitation Items, Document AI/SE-M4/95A.0252/96, Issue 7, dated... ALI Document reference AI/SE-M4/95A.0252/ 96 and Airbus A319 Corporate Jet ALI Document reference AI... specified in Airbus A318/A319/A320/A321 ALI Document reference AI/ SE-M4/95A.0252/96 issue 10 and...

  5. Minimum Nuclear Deterrence Postures in South Asia: An Overview

    DTIC Science & Technology

    2001-10-01

    the context of the publication in India of the "NSAB Draft Report ... on Indian Nuclear Doctrine," is Agha Shahi, Zulfiqar Ali Khan and Abdul Sattar...Minister of Pakistan, and Air Marshall Zulfiqar Ali Khan formerly was Pakistan’s Air Force Commander in Chief. 50 President Pervez Musharraf’s Oct. 19...pp. 67-87. Shahi, Agha, Air Marshall (retd.) Zulfiqar Ali Khan and Abdul Sattar, "Securing Nuclear Peace," The News International, October 5, 1999

  6. Developing an Evaluation Method for Middleware-Based Software Architectures of Airborne Mission Systems

    DTIC Science & Technology

    2007-07-01

    documented using an architecture knowledge management tool also developed at NICTA. 31 DSTO-TR-2204 9. References [Ali- Babar & Gorton 2004] [Ali... Babar et al. 2005] [Allen et al. 2002] [Bachmann et al. 2003] [Barbacci et al. 1995] [Bass et al. 2003] [Basse/al. 2001] [Bengstsson et al. 2004...Boehm&In 1996] [CORBA 2006] [Clements et al. 2001] Ali- Babar , M. & Gorton, I. (2004) Comparison of Scenario-Based Software Architecture

  7. Islamic Fundamentalism in Pakistan. Its Characters and Prospects

    DTIC Science & Technology

    1991-01-01

    For although Pakistan was founded as a Muslim homeland, it was not at all the intention of its founder, Muhammad Ali Jinnah , that the state should be...origin: "* The founder of Pakistan, Muhammad ’ Ali Jinnah , was of Isma’ili background; "* Yahya Khan, former Commander in Chief of the Army, and then...more interested in socialist policies or regional issues. Islam entered more fully into the political debate when former Prime Minister Zulfikar Ali

  8. Pakistan, Madrassas, and Militancy

    DTIC Science & Technology

    2006-12-01

    not part of this proposed Muslim state. 18 with a Muslim majority.50 Also in the 1930s, Mohammed Ali Jinnah , a Bombay lawyer and future father of...Terror Networks, Princeton University Press, 2004. Peter Bergan “The Madrassa Scapegoat,” The Washington Quarterly 29:2 (Spring 2006), 117. 4 Ali Riaz...Saleem Ali . Islamic Education and Conflict: Understanding the Madrassas of Pakistan. Oxford University Press. August 2005. 3 development of the

  9. JPRS Report, Near East & South Asia: Pakistan

    DTIC Science & Technology

    1993-06-15

    to "hear no evil", "see no evil" and "speak no Factories boss Maj. Gen. Mahmood Ali Durrani, an evil" are secretly decided in advance by mutual...nuclear technology, especially to the Middle East..." [Text] Whether the recent meeting between Pakistan’s Federal Minister, Chaudhry Nisar Ali , who...Nisar Ali , On his part, gave Mr Warren Christopher every obtain Russian cyrogenic [as published] rocket engines assurance that Pakistan was opposed

  10. Internal Security Threats to Pakistan

    DTIC Science & Technology

    2004-12-01

    because of the personalities of two topmost leaders, M. A. Jinnah and Liaquat Ali Khan. But after the assassination of Liaquat Ali in 1951...APPENDIX H. HEADS OF STATE AND GOVERNMENT, 1947-99 Leader Position1 Term of Office2 Mohammad Ali Jinnah Governor General August 1947-September...affiliations with militant groups are discussed at length. Pakistan came into existence as a moderate and modern nation state under the vision of Jinnah

  11. Stability in Pakistan: Realizing the Vision of Enlightened Moderation

    DTIC Science & Technology

    2006-06-01

    include the visions of Mohammad Ali Jinnah and Mohammad Iqbal in the establishment 3 Feroz H. Khan...been the struggle to define Pakistan’s identity, represented generally by two ideals. One ideal is held by moderate thinkers, such as Mohammed Ali ...Wolpert, 341. 75 Maulana Azad, “The Mission Plan Was Practicable,” Wallbank, 69. 28 compromise, Muhammad Ali Jinnah (1876-1948), member of Congress

  12. Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase from Pseudoalteromonas sp. SM0524

    PubMed Central

    Chen, Xiu-Lan; Dong, Sheng; Xu, Fei; Dong, Fang; Li, Ping-Yi; Zhang, Xi-Ying; Zhou, Bai-Cheng; Zhang, Yu-Zhong; Xie, Bin-Bin

    2016-01-01

    Marine bacterial alginate lyases play a role in marine alginate degradation and carbon cycling. Although a large number of alginate lyases have been characterized, reports on alginate lyases with special characteristics are still rather less. Here, a gene alyPM encoding an alginate lyase of polysaccharide lyase family 7 (PL7) was cloned from marine Pseudoalteromonas sp. SM0524 and expressed in Escherichia coli. AlyPM shows 41% sequence identity to characterized alginate lyases, indicating that AlyPM is a new PL7 enzyme. The optimal pH for AlyPM activity was 8.5. AlyPM showed the highest activity at 30°C and remained 19% of the highest activity at 5°C. AlyPM was unstable at temperatures above 30°C and had a low Tm of 37°C. These data indicate that AlyPM is a cold-adapted enzyme. Moreover, AlyPM is a salt-activated enzyme. AlyPM activity in 0.5–1.2 M NaCl was sixfolds higher than that in 0 M NaCl, probably caused by a significant increase in substrate affinity, because the Km of AlyPM in 0.5 M NaCl decreased more than 20-folds than that in 0 M NaCl. AlyPM preferably degraded polymannuronate and mainly released dimers and trimers. These data indicate that AlyPM is a new PL7 endo-alginate lyase with special characteristics. PMID:27486451

  13. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.

    PubMed

    Zhang, Hong; Neuhöfer, Patrick; Song, Liang; Rabe, Björn; Lesina, Marina; Kurkowski, Magdalena U; Treiber, Matthias; Wartmann, Thomas; Regnér, Sara; Thorlacius, Henrik; Saur, Dieter; Weirich, Gregor; Yoshimura, Akihiko; Halangk, Walter; Mizgerd, Joseph P; Schmid, Roland M; Rose-John, Stefan; Algül, Hana

    2013-03-01

    Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-κB induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI.

  14. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

    PubMed Central

    Zhang, Hong; Neuhöfer, Patrick; Song, Liang; Rabe, Björn; Lesina, Marina; Kurkowski, Magdalena U.; Treiber, Matthias; Wartmann, Thomas; Regnér, Sara; Thorlacius, Henrik; Saur, Dieter; Weirich, Gregor; Yoshimura, Akihiko; Halangk, Walter; Mizgerd, Joseph P.; Schmid, Roland M.; Rose-John, Stefan; Algül, Hana

    2013-01-01

    Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis–associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-κB induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI. PMID:23426178

  15. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity

    PubMed Central

    ZHU, GUANG-FA; GUO, HONG-JUAN; HUANG, YAN; WU, CHUN-TING; ZHANG, XIANG-FENG

    2015-01-01

    Acute lung injury (ALI) is characterized by excessive inflammatory responses and oxidative injury in the lung tissue. It has been suggested that anti-inflammatory or antioxidative agents could have therapeutic effects in ALI, and eriodictyol has been reported to exhibit antioxidative and anti-inflammatory activity in vitro. The aim of the present study was to investigate the effect of eriodictyol on lipopolysaccharide (LPS)-induced ALI in a mouse model. The mice were divided into four groups: Phosphate-buffered saline-treated healthy control, LPS-induced ALI, vehicle-treated ALI (LPS + vehicle) and eriodictyol-treated ALI (LPS + eriodictyol). Eriodictyol (30 mg/kg) was administered orally once, 2 days before the induction of ALI. The data showed that eriodictyol pretreatment attenuated LPS-induced ALI through its antioxidative and anti-inflammatory activity. Furthermore, the eriodictyol pretreatment activated the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in the ALI mouse model, which attenuated the oxidative injury and inhibited the inflammatory cytokine expression in macrophages. In combination, the results of the present study demonstrated that eriodictyol could alleviate the LPS-induced lung injury in mice by regulating the Nrf2 pathway and inhibiting the expression of inflammatory cytokines in macrophages, suggesting that eriodictyol could be used as a potential drug for the treatment of LPS-induced lung injury. PMID:26668626

  16. Site characterization studies in high plateau of Tibet

    NASA Astrophysics Data System (ADS)

    Yao, Yongqiang; Wang, Hongshuai; Liu, Liyong; Wang, Yiping; Qian, Xuan; Yin, Jia

    2012-09-01

    The site survey in western China has been carried out since 2003. Remote studies and local surveys are performed, and Oma site, Ali area in southwest Tibet, has been selected in 2005 to make site testing measurements. The monitoring results show that Ali area can be the best choice for astronomical observations over the East Asian regions. A new site in Ali has been identified and begun construction in 2010 for small telescopes and detailed site characterization. This paper reviews the long term site survey, presents site characteristics in Tibet, and introduces current status of the new Ali observatory.

  17. Cardiorespiratory effects of spontaneous breathing in two different models of experimental lung injury: a randomized controlled trial

    PubMed Central

    Varelmann, Dirk; Muders, Thomas; Zinserling, Jörg; Guenther, Ulf; Magnusson, Anders; Hedenstierna, Göran; Putensen, Christian; Wrigge, Hermann

    2008-01-01

    Introduction Acute lung injury (ALI) can result from various insults to the pulmonary tissue. Experimental and clinical data suggest that spontaneous breathing (SB) during pressure-controlled ventilation (PCV) in ALI results in better lung aeration and improved oxygenation. Our objective was to evaluate whether the addition of SB has different effects in two different models of ALI. Methods Forty-four pigs were randomly assigned to ALI resulting either from hydrochloric acid aspiration (HCl-ALI) or from increased intra-abdominal pressure plus intravenous oleic acid injections (OA-ALI) and were ventilated in PCV mode either with SB (PCV + SB) or without SB (PCV – SB). Cardiorespiratory variables were measured at baseline after induction of ALI and after 4 hours of treatment (PCV + SB or PCV – SB). Finally, density distributions and end-expiratory lung volume (EELV) were assessed by thoracic spiral computed tomography. Results PCV + SB improved arterial partial pressure of oxygen/inspiratory fraction of oxygen (PaO2/FiO2) by a reduction in intrapulmonary shunt fraction in HCl-ALI from 27% ± 6% to 23% ± 13% and in OA-ALI from 33% ± 19% to 26% ± 18%, whereas during PCV – SB PaO2/FiO2 deteriorated and shunt fraction increased in the HCl group from 28% ± 8% to 37% ± 17% and in the OA group from 32% ± 12% to 47% ± 17% (P < 0.05 for interaction time and treatment, but not ALI type). PCV + SB also resulted in higher EELV (HCl-ALI: 606 ± 171 mL, OA-ALI: 439 ± 90 mL) as compared with PCV – SB (HCl-ALI: 372 ± 130 mL, OA-ALI: 192 ± 51 mL, with P < 0.05 for interaction of time, treatment, and ALI type). Conclusions SB improves oxygenation, reduces shunt fraction, and increases EELV in both models of ALI. PMID:18980696

  18. 78 FR 66713 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ..., Baldwin, NY 11510. Officer: Kamran Ali, President (QI), Application Type: New NVO & OFF License. Miragrown... 2D, Philadelphia, PA 19115. Officers: Mykola Chobotar, Chief Executive Manager (QI), James...

  19. Recurrent Arterial Thrombosis as a Presenting Feature of a Variant M3-Acute Promyelocytic Leukemia

    PubMed Central

    Chotai, Pranit N.; Kasangana, Kalenda; Chandra, Abhinav B.; Rao, Atul S.

    2016-01-01

    Acute limb ischemia (ALI) is a common vascular emergency. Hematologic malignancies are commonly associated with derangement of normal hemostasis and thrombo-hemorrhagic symptoms during the course of the disease are common. However, ALI as an initial presenting feature of acute leukemia is rare. Due to the rarity of this presentation, there is a scarcity of prospective randomized data to optimally guide the management of these patients. Current knowledge is mainly based on isolated cases. We report our experience managing a patient who presented with ALI and was found to have occult leukemia. A review of all cases with ALI as a presenting feature of acute leukemia is also presented. PMID:27386455

  20. Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.

    PubMed

    Liu, Cong-Lin; Wang, Yi; Liao, Mengyang; Santos, Marcela M; Fernandes, Cleverson; Sukhova, Galina K; Zhang, Jin-Ying; Cheng, Xiang; Yang, Chongzhe; Huang, Xiaozhu; Levy, Bruce; Libby, Peter; Wu, Gongxiong; Shi, Guo-Ping

    2016-05-01

    Inflammation drives asthma and atherosclerosis. Clinical studies suggest that asthmatic patients have a high risk of atherosclerosis. Yet this hypothesis remains uncertain, given that Th2 imbalance causes asthma whereas Th1 immunity promotes atherosclerosis. In this study, chronic allergic lung inflammation (ALI) was induced in mice by ovalbumin sensitization and challenge. Acute ALI was induced in mice by ovalbumin and aluminum sensitization and ovalbumin challenge. Atherosclerosis was produced in apolipoprotein E-deficient (Apoe(-/-)) mice with a Western diet. When chronic ALI and atherosclerosis were produced simultaneously, ALI increased atherosclerotic lesion size, lesion inflammatory cell content, elastin fragmentation, smooth muscle cell (SMC) loss, lesion cell proliferation, and apoptosis. Production of acute ALI before atherogenesis did not affect lesion size, but increased atherosclerotic lesion CD4(+) T cells, lesion SMC loss, angiogenesis, and apoptosis. Production of acute ALI after atherogenesis also did not change atherosclerotic lesion area, but increased lesion elastin fragmentation, cell proliferation, and apoptosis. In mice with chronic ALI and diet-induced atherosclerosis, daily inhalation of a mast cell inhibitor or corticosteroid significantly reduced atherosclerotic lesion T-cell and mast cell contents, SMC loss, angiogenesis, and cell proliferation and apoptosis, although these drugs did not affect lesion area, compared with those that received vehicle treatment. In conclusion, both chronic and acute ALI promote atherogenesis or aortic lesion pathology, regardless whether ALI occurred before, after, or at the same time as atherogenesis. Antiasthmatic medication can efficiently mitigate atherosclerotic lesion pathology.

  1. Bioregenerative Planetary Life Support Systems Test Complex (BIO-Plex): NASA's Next Human-Rated Testing Facility

    NASA Technical Reports Server (NTRS)

    Tri, Terry O.

    1999-01-01

    As a key component in its ground test bed capability, NASA's Advanced Life Support Program has been developing a large-scale advanced life support test facility capable of supporting long-duration evaluations of integrated bioregenerative life support systems with human test crews. This facility-targeted for evaluation of hypogravity compatible life support systems to be developed for use on planetary surfaces such as Mars or the Moon-is called the Bioregenerative Planetary Life Support Systems Test Complex (BIO-Plex) and is currently under development at the Johnson Space Center. This test bed is comprised of a set of interconnected chambers with a sealed internal environment which are outfitted with systems capable of supporting test crews of four individuals for periods exceeding one year. The advanced technology systems to be tested will consist of both biological and physicochemical components and will perform all required crew life support functions. This presentation provides a description of the proposed test "missions" to be supported by the BIO-Plex and the planned development strategy for the facility.

  2. Bilingualism and Bilingual Education: New Readings and Insights.

    ERIC Educational Resources Information Center

    Ornstein-Galicia, Jacob, Ed.; St. Clair, Robert, Ed.

    The following articles on bilingualism and bilingual education are included: "The Lessons from Two Decades of Bilingual Theory and Practice of Bilingual Education" (Inclan); "Social and Psychological Aspects of Language Use by Bilingual Children" (Walcer and Rodriguez-Brown); "Psychological Aspects of Bilingualism and Biculturalism in Mexican…

  3. 76 FR 68368 - Airworthiness Directives; DASSAULT AVIATION Model MYSTERE-FALCON 900 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... after receipt. FOR FURTHER INFORMATION CONTACT: Tom Rodriguez, Aerospace Engineer, International Branch... necessary to use different words from those in the MCAI to ensure the AD is clear for U.S. operators and is... on U.S. operators to be $477,400, or $4,340 per product. Authority for This Rulemaking Title 49...

  4. Atomic-Scale Investigation of Graphene Grown on Cu Foil and the Effects of Thermal Annealing

    DTIC Science & Technology

    2011-01-01

    R. R.; Mohiuddin, T. M. G.; Morozov, S. V.; Blake, P.; Halsall, M. P.; Ferrari , A. C.; Boukhvalov, D. W.; Katsnelson, M. I.; Geim, A. K.; et al...R.; Gomez -Rodriguez, J. M.; Colchero, J.; Gomez -Herrero, J.; Baro, A. M. WSXM: A Software for Scanning Probe Microscopy and a Tool for Nanotechnol- ogy. Rev. Sci. Instrum. 2007, 78, 013705. A RTIC LE

  5. California on the Verge of a Fourth Wave of School Finance Reform

    ERIC Educational Resources Information Center

    Slater, Charles L.; Scott, James

    2011-01-01

    Equity issues in public school finance have been discussed in terms of three waves. The first wave was a challenge to the U.S. Supreme Court to provide equal education to all students as a fundamental right. After a ruling against the plaintiffs in "San Antonio v Rodriguez" (1973), the fight shifted to a second wave in the state courts.…

  6. 75 FR 58446 - Notice of Issuance of Amendment No. 1 for Special Nuclear Material License No. SNM-1227 [AREVA NP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... CONTACT: Rafael L. Rodriguez, Project Manager, Fuel Manufacturing Branch, Division of Fuel Cycle Safety... fabrication facility in Richland, Washington, that will use supercritical carbon dioxide to extract uranium..., Division of Fuel Cycle Safety and Safeguards, Office of Nuclear Material Safety and Safeguards....

  7. 76 FR 59361 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ..., identified by Docket No. FEMA-B-1216, to Luis Rodriguez, Chief, Engineering Management Branch, Federal... section 3(f) of Executive Order 12866, as amended. Executive Order 13132, Federalism. This proposed rule... feet None +2599 upstream of Hawknest Road. Camp Creek Tributary B At the downstream limit None...

  8. Research as Discovery, Teaching as Trust: Developing New Perspectives through Teacher Research

    ERIC Educational Resources Information Center

    Blumenreich, Megan; Rodriguez, Rafaela

    2016-01-01

    This paired-format article describes how one of the authors (Rodriguez) undertook a teacher research study of homework in the urban first-grade classroom in which she was a paraprofessional. Her findings influenced her to broaden her perspective on homework. Her graduate professor (Blumenreich) discusses the challenge of supporting a student to…

  9. 75 FR 3523 - Additional Designation of Entities and Individuals Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ...); (INDIVIDUAL) . 11. LOPEZ RODRIGUEZ, Walter, c/o CARMILE INVERSIONES LOPEZ Y CIA. S.C.A., Cali, Colombia; c/o... INVERSIONES LOPEZ Y CIA. S.C.A., Cali, Colombia; c/o INVERSIONES MEDICAS Y QUIRUGICAS ESPECIALIZADAS LTDA... TERESITA S.A., Cali, Colombia; c/o BOSQUE DE SANTA TERESITA LTDA., Cali, Colombia; c/o SAAVEDRA Y CIA....

  10. Litigation and School Finance: A Cautionary Tale

    ERIC Educational Resources Information Center

    Russo, Charles J.

    2010-01-01

    Beginning in the early 1970s, plaintiffs initiated a veritable tidal wave of litigation over financing public education in states with unequal funding for students in poor school systems. In the only case on school finance to reach the United States Supreme Court, "San Antonio Independent School District v. Rodriguez" (1973), the…

  11. 76 FR 8622 - Airworthiness Directives; Fokker Services B.V. Model F.28 Mark 0070 and 0100 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... products listed above. This AD results from mandatory continuing airworthiness information (MCAI...., Washington, DC. FOR FURTHER INFORMATION CONTACT: Tom Rodriguez, Aerospace Engineer, International Branch, ANM...; telephone (425) 227-1137; fax (425) 227-1149. SUPPLEMENTARY INFORMATION: Discussion We issued a notice...

  12. The pharmacogenetics of body odor: as easy as ABCC?

    PubMed

    Brown, Sara

    2013-07-01

    ABCC11 genotype affects apocrine secretory cell function and determines individual body odor phenotype. Rodriguez et al. have applied genetic epidemiology using predetermined phenotype data to demonstrate an association between a single-nucleotide polymorphism (rs17822931) and the human behavior of deodorant application. Individuals with the ABCC11 genotype predicting a nonodorous phenotype report a significantly lower frequency of deodorant use.

  13. Autobiographical Accounts of L2 Identity Construction in Chicano Literature

    ERIC Educational Resources Information Center

    i Sole, Cristina Ros

    2004-01-01

    This paper uses narrative accounts to explore intercultural experiences and the perception of the self by second language (L2) users. The analysis follows poststructuralist and postmodern theories of cultural and language identity. Extracts from the autobiographies of three chicano writers from the 1980s to the new millennium, Richard Rodriguez's…

  14. Tongue-Tied: The Lives of Multilingual Children in Public Education

    ERIC Educational Resources Information Center

    Santa Ana, Otto

    2004-01-01

    Tongue-Tied is an anthology that gives voice to millions of people who, on a daily basis, are denied the opportunity to speak in their own language. First-person accounts by Amy Tan, Sherman Alexie, Bell Hooks, Richard Rodriguez, Maxine Hong Kingston, and many other authors open windows into the lives of linguistic minority students and their…

  15. Latin America Report. No. 2738.

    DTIC Science & Technology

    1983-09-14

    Acero Espinosa; EL TIEMPO, 25 Jul 83) 23 Rodriguez Report to L.A. Economists Meeting Published (Roberto Molina; PRISMA LATINOAMERICANO, Jul 83...CUNDINAMARCA Bogota EL TIEMPO in Spanish 25 Jul 83 p 10-D [Article by special correspondent German Acero Espinosa] [Text] La Mesa, Cundinamarca—We

  16. Access and Success with Less: Improving Productivity in Broad-Access Postsecondary Institutions

    ERIC Educational Resources Information Center

    Jenkins, Davis; Rodriguez, Olga

    2013-01-01

    Achieving national goals for increased college completion in a time of scarce resources will require the postsecondary institutions that enroll the majority of undergraduates--community colleges and less-selective public universities--to graduate more students at a lower cost. Davis Jenkins and Olga Rodriguez examine research on how these…

  17. 78 FR 45944 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ..., 2013. ADDRESSES: The Preliminary Flood Insurance Rate Map (FIRM), and where applicable, the Flood Insurance Study (FIS) report for each community are available for inspection at both the online location and... Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...

  18. Augmentation of Early Intensity Forecasting in Tropical Cyclones

    DTIC Science & Technology

    2012-09-30

    Rodriguez- Herrera, Matthew E. Kucas, and James W. E. Darlow, “A Web-based Interactive Interface for Researching and Forecasting Tropical Cyclone ...Augmentation of Early Intensity Forecasting in Tropical Cyclones J. Scott Tyo College of Optical Sciences...an objective and automatic intensity estimator of Tropical Cyclones (TCs) based on satellite infrared (IR) imagery. The proposed methodology analyzes

  19. Imaging Bilinguals: When the Neurosciences Meet the Language Sciences.

    ERIC Educational Resources Information Center

    Grosjean, Francois; Li, Ping; Munte, Thomas F.; Antoni, Rodriguez-Fornells

    2003-01-01

    The Rodriguez-Fornells, Rotte, Heinze, Nosselt, and Munte (2002) paper "Brain Potential and Functional MRI Evidence for How to Handle Two Languages with One Brain," is discussed by two of two of its authors, both neuroscientists, and by two language scientists. (Author/VWL)

  20. High-Frequency Propagation in the Ocean Waveguide

    DTIC Science & Technology

    2016-06-07

    Acoustics, Eds. S. Jesus and O. Rodriguez, Carvoeiro, Portugal (2006). 2. M. Siderius, M. Porter and C. Harrison , “An Ambient Noise Fathometer for...Blondel, (September 2005). 3. Martin Siderius, Christopher Harrison , Michael Porter, “A passive fathometer technique for imaging seabed layering using

  1. Novel Solution and Solid-State Properties of Ampholytic Ionomers from Ion-Pair Comonomers.

    DTIC Science & Technology

    1986-09-30

    and C.R. Russell; J. Appl. Polym. Sci., 23, 229 (1979). -10- ~A 4 .t. A .1 2. PAPER SUBMITTED TO REFEREED JOURNAL "Drag Reduction by Acrylamide ... Copolymers ", J.C. Salamone, E.C. Rodriguez, S.C. Israel, I. Ahmed and A.C. Watterson, Current Topics in Polvmer Science-1984, in press. 3. PAPER PUBLISHED

  2. Assessment Update: Progress, Trends, and Practices in Higher Education. Volume 24, Issue 6, November-December 2012

    ERIC Educational Resources Information Center

    Banta, Trudy W., Ed.

    2012-01-01

    This issue of "Assessment Update" presents the following articles: (1) Accreditation and Assessment: The Root of My Teaching Metamorphosis (Barbara June Rodriguez); (2) Editor's Notes: Addressing a Question of Credibility (Trudy W. Banta); (3) Do We Practice What We Preach? The Accountability of an Assessment Office (Keston H. Fulcher…

  3. 77 FR 25536 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    .../o INVERSIONES MIGUEL RODRIGUEZ E HIJO, Cali, Colombia; c/o RADIO UNIDAS FM S.A., Cali, Colombia; c/o.... AVILA DE MONDRAGON, Ana Dolores, c/o COMPAX LTDA., Cali, Colombia; c/o INVERSIONES Y CONSTRUCCIONES COSMOVALLE LTDA., Cali, Colombia; c/o INVERSIONES Y CONSTRUCCIONES ABC S.A., Cali, Colombia; DOB 22 Dec...

  4. Teacher Motivation as an Enhancement to the First Step to Success Early Intervention Program for Children with Tertiary Level Behavioral Challenges

    ERIC Educational Resources Information Center

    Lee, Jon

    2012-01-01

    The First Step to Success early intervention program (Walker, 1998) is a secondary prevention intervention that targets primary grade children with moderate or emerging behavior disorders. While the effectiveness of the First Step to Success early intervention program has been documented repeatedly (see Loman, Rodriguez, & Horner, 2010; Walker…

  5. How to Foster Student-Student Learning of Science? The Student, the Teacher and the Subject Matter

    ERIC Educational Resources Information Center

    Bianchini, Julie A.

    2011-01-01

    In this response to Konstantinos Alexakos, Jayson K. Jones, and Victor H. Rodriguez's study, I discuss ways attending to student membership in groups can both inform research on equity and diversity in science education and improve the teaching of science to all students. My comments are organized into three sections: how underrepresented…

  6. 76 FR 28376 - Airworthiness Directives; Fokker Services B.V. Model F.28 Mark 1000, 2000, 3000, and 4000 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Authorities (JAA) have published Interim Policy INT/POL/25/ 12. The review conducted by Fokker Services on the... corrected, may create an ignition source in the tank vapour space, possibly resulting in a wing fuel tank... after receipt. FOR FURTHER INFORMATION CONTACT: Tom Rodriguez, Program Manager, International...

  7. Becoming a Youth Activist in the Internet Age: A Case Study on Social Media Activism and Identity Development

    ERIC Educational Resources Information Center

    Fullam, Jordan

    2017-01-01

    This paper draws on a case study of one youth activist, and explores connections between social media activism, identity development, and critical education. Justin Rodriguez, a 17-year-old high school student in Newark, New Jersey, leveraged social media and texting as organizing tools and garnered support for a school walkout to protest…

  8. Annual Conference Journal NABE '90-'91. Proceedings of the National Association for Bilingual Education Conferences (Tucson, Arizona, 1990; Washington, D.C., 1991).

    ERIC Educational Resources Information Center

    Malave, Lilliam M., Ed.

    Papers from the 1990 and 1991 conferences of the National Association for Bilingual Education (NABE) are presented, including: "Beyond Socially Naive Bilingual Education: The Effects of Schooling and Ethnolinguistic Vitality of the Community on Additive and Subtractive Bilingualism" (Rodriguez Landry, Real Allard); "Descubriendo la…

  9. Teaching Strategies: Self-Created Children's Literature as a Teaching Strategy--Voices from the College and the Elementary Classroom

    ERIC Educational Resources Information Center

    Szilagyi, Janka; Zarazinski, Jill

    2012-01-01

    Researchers have noticed a shift in education, with science and social studies taking a backseat to mathematics and literacy (Marx & Harris, 2006; Rodriguez, 2006). Some school districts are operating on a rotating basis with science instruction--one month on and one month off (Marx & Harris, 2006). A better approach would be to encourage students…

  10. Study of Xanthorhodopsin, the Retinal-Protein Proton Pump of Salinibacter ruber with Light-Harvesting Carotenoid Antenna

    DTIC Science & Technology

    2009-03-19

    conds [17]. Both Sz and Sj states were identified as energy donors in carotenoid- (bacterio)chlorophylls antenna systems. For carotenoids with... Perez , A K Sharma, C. L. Nesb0, D. MacLeod, E. Bapteste, W. F. Doolittle, R. L. Charlebois, B. Legault, and F. Rodriguez- Valera. 2005. The genome of

  11. Effects of Amplitude Compression on Relative Auditory Distance Perception

    DTIC Science & Technology

    2013-10-01

    were connected to the laptop via the headphone port . An HA-1 coupler was connected to a Quest 1900 Sound Level Meter (set in fast/linear mode) and...RDRL HRT G A RODRIGUEZ RDRL HRT I J HART RDRL HRT M C METEVIER RDRL HRT S B PETTIT 12423 RESEARCH PARKWAY ORLANDO FL

  12. TOROID II

    DTIC Science & Technology

    2009-01-01

    Active MAE Senior 10 Structure Keith Bradford Active MAE Senior 10 Structure Jonathon Howell Inactive MAE Junior 20 Avionics Cory Brinck Active ECE...Lead Cory Brinck 08-09 Ryan Keith 07-08 Paul Rodriguez 07 Power Lead Daniel Perkins 07-09 Joshua Daley 07 Software Lead Mark Andersen 08-09

  13. Tempest, Arizona: Criminal Epistemologies and the Rhetorical Possibilities of Raza Studies

    ERIC Educational Resources Information Center

    Serna, Elias

    2013-01-01

    This essay looks at Ethnic Studies activism in Arizona through a rhetorical lens in order to highlight epistemological aspects of activities such as a high school Chicano Literature class, Roberto "Dr. Cintli" Rodriguez's journalism, and student activism to defend the Mexican-American Studies Department. Taking rhetoric's premise that…

  14. Multiple Antigen Peptide Vaccines against Plasmodium falciparum Malaria

    DTIC Science & Technology

    2010-01-01

    M. Vanegas, L. M. Salazar , and M. E. Patarroyo. 2000. Serine repeat antigen peptides which bind specifically to red blood cells. l’arasitol. Int...J. Immunol. 154:6022-򓭦. 58. Urquiza, M., 1 .. E. Rodriguez, J. E. Suarez , 1<’. Guzman, M. Ocampo, H. Curtidor, C. Segura, E. Trujillo, and M. E

  15. Interdependence in the U.S.-Mexican Borderlands: An Irresistible Dynamic or Fragmented Reality?

    DTIC Science & Technology

    1983-06-01

    Chicanos have developed their own distinctive music and language patterns (Browning and Rodriguez, 1982), and, as Octavio Paz (1961) has pointed out, the...2887-FF/RF/RC/NICHD. McWilliams, Carey. 1964. Brothers Under the Skin. Little Brown, Boston. 0 -18 - Paz , Octavio . 1961. The Labyrinth of Solitude. Grove

  16. Tissue Engineering and Regenerative Medicine

    DTIC Science & Technology

    2006-11-01

    Mark Furth Mark Van Dyke Shay Soker Steve Hodges Weixin Zhao YuanYuan Zhang Aaron Goldstein Alan Farney Ann Gleeson Ann Immekus Ben Watts Callie Crider...Myers Robyn Shaffer Saami Yazdani Samira Neshat Sang Jin Lee Sergio Rodriguez Shirin Zare So-Young Chun Steve Schultz Tamer AbouShawreb Tao Xu Ted Kincaid

  17. 77 FR 27076 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ..., identified by Docket No. FEMA-B-1254, to Luis Rodriguez, Chief, Engineering Management Branch, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500 C Street SW... resolution process. SRPs are independent panels of experts in hydrology, hydraulics, and other...

  18. Developmental and Environmental Regulation of AaeIAP1 Transcript in Aedes aegypti

    DTIC Science & Technology

    2008-01-01

    swine fever virus IAP ho- molog is a late structural polypeptide. Virology 214: 670Ð 674. Christophers, S. R. 1960. Aedes aegypti (L.) the yellow fever...Aedes triseriatusmosquitoes. Insect Mol. Biol. 11: 431Ð442. Chacon,M. R., F. Almazan,M. L. Nogal, E. Vinuela, and J. F. Rodriguez. 1995. The African

  19. 77 FR 77087 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... or modification of Base Flood Elevations (BFEs), base flood depths, Special Flood Hazard Area (SFHA... Administration, FEMA, 500 C Street SW., Washington, DC 20472, (202) 646-4064, or (email) Luis.Rodriguez3@fema.dhs... Commerce team.com/lomrs.htm. Mayor, City of Street, 7th San Antonio, 100 Floor, San Military Plaza,...

  20. Projects and Themes. Beginnings Workshop.

    ERIC Educational Resources Information Center

    Pelo, Ann; And Others

    2002-01-01

    Four articles address topics related to projects and themes: (1) "Supporting Young Children as Activists: Anti- bias Project Work" (Pelo); (2) "A Study of Hands: Chicago Commons Explores Reggio Emilia" (Harger, Rodriguez, & Schroeder); (3) "A Personal Experience with Portfolio Books" (Meinen); and (4)…

  1. 75 FR 70675 - Agency Information Collection Activities; Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... preexisting business relationship with a consumer, using information in response to a communication initiated... requirements described below will be submitted to the Office of Management and Budget (``OMB'') for review, as... Anthony Rodriguez, Attorney, Division of Privacy and Identity Protection, Bureau of Consumer...

  2. Learning's Professional Reading for Teachers.

    ERIC Educational Resources Information Center

    Ohanian, Susan

    1982-01-01

    A "Learning" magazine editor recommends five books for teachers: (1) "Hunger of Memory" (Richard Rodriguez); (2) "Cushla and Her Books" (Dorothy Butler); (3) "Uncivil Liberties" (Calvin Trillin); (4) "Selected Letters of James Thurber"; and (5) "The Selected Letters of Mark Twain." A…

  3. First-Generation Latino Males in Latino Fraternities at a Predominately White Institution: Psychological, Social, and Cultural College Experiences

    ERIC Educational Resources Information Center

    Sanchez, Sheila Marie

    2011-01-01

    This research study explores the first-generation undergraduate Latino male student experience at a Predominantly White Institution (PWI) affiliated within Latino Greek fraternities. The Psychosociocultural (PSC) model (Gloria & Rodriguez, 2000; Pope & Reynolds, 2000) that is used highlights the psychological, social and cultural contributing…

  4. Histone Code Modulation by Oncogenic PWWP-domain Protein in Breast Cancers

    DTIC Science & Technology

    2012-06-01

    were prepared from cells by using the RNeasy Plus Mini Kit (Qiagen, Valencia , CA, USA) and were converted into complementary DNAs with the qScript...application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55–63. Natrajan R, Lambros MB, Rodriguez -Pinilla SM, Moreno-Bueno G, Tan DS

  5. 78 FR 43901 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering ] Management Branch, Federal Insurance and Mitigation... 060729 Clarita (12-09- Kellar, Mayor, Valencia www.r9map.org/ 2819P). City of Santa Boulevard, Suite Docs/12-09-2819P- Clarita, 23920 300, Santa 060729- Valencia Clarita, CA 102IAC.pdf. Boulevard,...

  6. 78 FR 78986 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation...-1328). Clarita, (12-09- Mayor, City of Santa Department, 23920 2819P). Clarita, 23920 Valencia Valencia...- Mayor, City of Santa Department, 23920 0273P). Clarita, 23920 Valencia Valencia Boulevard,...

  7. 77 FR 39717 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... West http:// June 15, 2012........ 060729 Clarita (12-09- Laurie Ender, Valencia www.bakeraecom.com...-county/. 23920 West Clarita, CA 91355. Valencia Boulevard, Santa Clarita, CA 91355. Los...

  8. Playful and Mindful Interactions in the Recursive Adaptations of the Zone of Proximal Development: A Critical Complexity Science Approach

    ERIC Educational Resources Information Center

    Raia, Federica; Deng, Mario C.

    2011-01-01

    We discuss Konstantinos Alexakos, Jayson Jones and Victor Rodriguez's hermeneutic study of formation and function of kinship-like relationships among inner city male students of color in a college physics classroom. From our Critical Complexity Science framework we first discuss the reading "erlebnisse" of students laughing at and with each other…

  9. Developing the Best Methods of Internal Contracting Support for Deployed Marine Expeditionary Units (MEU)

    DTIC Science & Technology

    2001-12-01

    advice, encouragement and help along the way. I greatly appreciate the advice of my fellow students Captain Rey Estrada and Captain John Gutierrez who...William CANARY ISLANDS LAS PALMAS, TENERIFE Delgado Rodriguez, Jacinto Gonzales Segura, Jose Lopez Agular, Ferico Morera Diepa, Santiago

  10. Predicting Upwelling Radiance on the West Florida Shelf

    DTIC Science & Technology

    2006-03-31

    central Gulf of Mexico and the waters of the Caribbean Sea via the Loop Current. These waters have typical open ocean color signals. In the deeper waters...Frazer, T.K., Iglesias -Rodriguez, D., Moline, M.A., Glenn, S. (2003). Development of Regional Coastal Ocean Observatories and the Potential Benefits to

  11. Predicting Upwelling Radiance on the West Florida Shelf

    DTIC Science & Technology

    2005-09-30

    low-colored waters of the WFS are derived from the oligotrophic waters of the central Gulf of Mexico and the waters of the Caribbean Sea via the...Waters. Journal of Geophysical Research, 190(C12S04): 12 [published, refereed]. Schofield, O., Bissett, W. P., Frazer, T.K., Iglesias -Rodriguez, D

  12. An Objective Rating Form to Evaluate Grant Proposals to the Hogg Foundation for Mental Health: A Pilot Study of Implementation

    ERIC Educational Resources Information Center

    Whaley, Arthur L.

    2006-01-01

    The lack of support for mental health-related projects by private philanthropy, even among those that express an interest in mental health, is due in large part to the subjectivity of the grant review process. To address this problem, Whaley, Rodriguez, and Alexander developed the Grant Proposal Rating Form (GPRF) to make the grant review process…

  13. 76 FR 79090 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... respective addresses are listed in the table below. FOR FURTHER INFORMATION CONTACT: Luis Rodriguez, Chief.... Bexar City of San Antonio September 27, 2011; The Honorable September 20, 2011 480045 (11-06-1217P). October 4, 2011; Juli n Castro, The San Antonio Mayor, City of San Express-News. Antonio, 100...

  14. The Supreme Court and the Suspect Class

    ERIC Educational Resources Information Center

    Casey, Patrick J.

    1973-01-01

    Focused on are factual and legal dissimilarities between the court case of San Antonio Independent School District versus Rodriguez (in which the Supreme Court ruled that education is not a fundamental right protected by the Constitution) and recent right to education for the handicapped cases. (DB)

  15. Update on State-Wide School Finance Cases.

    ERIC Educational Resources Information Center

    Lawyers' Committee for Civil Rights Under Law, Washington, DC.

    This summary provides an overview of developments in school finance litigation since the United States Supreme Court's historic and lamentable 1973 ruling in "San Antonio Independent School District v. Rodriguez" that wealth-based discrimination in educational expenditures does not violate the equal protection clause of the Fourteenth Amendment to…

  16. Minorities, the Poor and School Finance Reform. Vol. 2: The Impact of Texas' 1975 School Finance Reform on Poor and Minority Children.

    ERIC Educational Resources Information Center

    Brischetto, Robert

    As part of a nine-volume, six-state study of the impact of school finance reforms on minorities and the poor, the author examines the history and effects of finance reform in Texas. He presents a political and socioeconomic profile of the state and discusses past Texas school financing, the role of the Rodriguez v. San Antonio Independent School…

  17. Exploring the Changing Face of Adequacy

    ERIC Educational Resources Information Center

    Alexander, Nicola A.

    2004-01-01

    Adequacy is a derived concept whose origins in the school finance literature probably stem from San Antonio Independent School District v. Rodriguez (1973), a landmark federal case. Although there is often a recycling of definitions, 3 decades later, there is still little consensus on how to operationalize that concept. The purpose of this article…

  18. An Update in Public School Finance Litigation.

    ERIC Educational Resources Information Center

    Alexander, M. David; And Others

    1984-01-01

    Reviews "Serrano vs. Priest,""San Antonio Independent School District No. 1 vs. Rodriguez," and cases litigated since 1977 that focus on the equalization of state school support programs. Notes a trend toward findings in favor of state financing schemes. (PGD)

  19. Public School Finance Problems in Texas. An Interim Report.

    ERIC Educational Resources Information Center

    Texas Research League, Austin.

    The U.S. District Court ruling in Rodriguez vs San Antonio Independent School District, which struck down Texas' school finance system as inequitable and unconstitutional, provided the impetus for publishing this interim report. The report documents the growing cost of State-supported public school programs--the primary concern prior to the…

  20. School Finance Litigation of the 1980s.

    ERIC Educational Resources Information Center

    Connelly, Mary J.; McGee, Jack

    1987-01-01

    In "San Antonio Independent School District v. Rodriguez" (1973), the U.S. Supreme Court ruled that the Texas school finance system did not violate the Fourteenth Amendment and that education was not a fundamental right deserving of strict judicial scrutiny. This paper discusses various school financing schemes recently challenged in…

  1. Education Adequacy Litigation and the Quest for Equal Educational Opportunity.

    ERIC Educational Resources Information Center

    Rebell, Michael A.

    1999-01-01

    This article discusses how many state courts, using the "judicially manageable" tools provided by state academic standards, are meeting the challenges set by "San Antonio Independent School District v. Rodriguez" in 1973. A generation ago this decision was regarded as a major setback to education reform because, faced with…

  2. Summary of State-Wide School Finance Cases Since 1973.

    ERIC Educational Resources Information Center

    Lawyers' Committee for Civil Rights Under Law, Washington, DC.

    This summary provides an overview of developments in school finance litigation since the United States Supreme Court's historic ruling in San Antonio Independent School District v. Rodriguez that wealth-based discrimination in educational expenditures does not violate the equal protection clause of the Fourteenth Amendment. The failure of the…

  3. Florida's Past and Future Roles in Education Finance Reform Litigation

    ERIC Educational Resources Information Center

    Bauries, Scott R.

    2006-01-01

    The state of Florida has since the time of "San Antonio v. Rodriguez" an education finance system called the Florida Education Finance Plan (FEFP), which makes substantial effort to equalize per-pupil spending in all of the state's school districts, while recognizing the local factors that may necessitate changes in that spending. Still,…

  4. 78 FR 32676 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... City of San The Honorable Municipal Plaza, http://www.rampp-team.com/ July 22, 2013 480045 Antonio (12-06- Julian Castro, 114 Commerce lomrs.htm. 2419P). Mayor, City of Street, 7th San Antonio, Floor,...

  5. Issues in School Finance.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Equal Educational Opportunity.

    This document compiles several studies on educational finance, including "Federal Aid to Education: Who Benefits?""The Financial Aspects of Equality of Educational Opportunity," and "Legislator's Guide for School Finance." Also included are two briefs filed in the San Antonio vs Rodriguez case and a listing of current school finance litigation.…

  6. 78 FR 21141 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation..., Manheim, PA 17545. Texas: Bexar (FEMA Docket No.: B-1278) City of San Antonio The Honorable Julian... Antonio, 100 7th Floor, San Military Plaza, San Antonio, TX 78205. Antonio, TX 78205. Bexar (FEMA...

  7. Local Control of Schools: Two Views of Its Nature as Found in the Rodriquez Decision Rendered by the United States Supreme Court.

    ERIC Educational Resources Information Center

    Maltby, Gregory P.

    This paper examines the two conflicting definitions of local control inherent in the majority and minority opinions in the 1973 U.S. Supreme Court decision, San Antonio Independent School District v. Rodriguez. The author agrees with the minority decision that lack of adequate funds, regardless of the number of legal constraints set down by the…

  8. School Financial Litigation: A Historical Summary.

    ERIC Educational Resources Information Center

    Fulton, Mary; Long, David

    Two landmark cases, "Serrano v Priest" (1971) and "Rodriguez v San Antonio" (1973) catapulted school finance litigation onto the political and educational scene. In their aftermath, 11 state supreme courts had ruled school funding systems unconstitutional while 12 state systems have been upheld as constitutional. Many…

  9. 78 FR 14565 - Changes in Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... INFORMATION CONTACT: Luis Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation... Antonio (12-06- Julian Castro, 114 West Commerce team.com/lomrs.htm. 4032P). Mayor, City of Street, 7th San Antonio, P.O. Floor, San Box 839966, San Antonio, TX 78205. Antonio, TX 78283....

  10. Inequalities in Educational Resources: Their Impact on Minorities and the Poor in Texas and California. Final Report.

    ERIC Educational Resources Information Center

    Brischetto, Robert; Arciniega, Tomas A.

    This research effort examines inequalities in educational input resources among school systems in Texas and California in light of the Rodriguez and Serrano court cases. Low-income families in both states were found to be in districts of low per-pupil-Expenditures and inferior educational services primarily because they are located in districts…

  11. 77 FR 59767 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, Federal..., NC 27514. Texas: Bexar (FEMA Docket No.: B- City of San Antonio November 28, 2011; The Honorable... Antonio San Antonio, 100 Express-News. Military Plaza, San Antonio, TX 78205. ] (Catalog of...

  12. An Evaluation of the Delaware State Public Elementary and Secondary Educational Equalization Laws.

    ERIC Educational Resources Information Center

    Link, Charles R.; And Others

    In the wake of court decisions in the cases of "Serrano v. Priest,""San Antonio Independent School District v. Rodriguez," and "Robinson v. Cahill," Congress set aside funds as part of Public Law 93-380 for state departments of education to study the equitability of current educational funding arrangements. This…

  13. Eventos de Septiembre (September Events).

    ERIC Educational Resources Information Center

    Toro, Leonor, Ed.

    Written in Spanish, this booklet contains brief information on 10 September events celebrated by Puerto Ricans: Arturo Somohano, the beginning of the academic year, Dia del Trabajo (Labor Day), Pedro Albizu Campos, Lola Rodriguez de Tio, William Howard Taft, El Grito de Lares, Dia del Indio Americano (American Indian Day), las retretas, and…

  14. Hydrogen Generation from Ammonia Borane and Water Through the Combustion Reactions with Mechanically Alloyed Al/Mg Powder

    DTIC Science & Technology

    2014-08-11

    AMMONIA BORANE AND WATER THROUGH THE...FROM AMMONIA BORANE AND WATER THROUGH THE COMBUSTION REACTIONS WITH MECHANICALLY ALLOYED AL/MG POWDER by DANIEL RODRIGUEZ THESIS Presented to the...generating compositions based on ammonia borane and novel energetic materials such as nanocomposite and mechanically alloyed reactive materials,

  15. Energetic Materials Laboratory

    DTIC Science & Technology

    2015-04-30

    Paper 3.00 4.00 Daniel A. Rodriguez, Edward L. Dreizin, Evgeny Shafirovich. Hydrogen generation from ammonia borane and water through combustion...Dreizin, E.L., and Shafirovich, E., “Hydrogen Generation from Ammonia Borane and Water through Combustion Reactions with Mechanically Alloyed

  16. The Xmath Integration Algorithm

    ERIC Educational Resources Information Center

    Bringslid, Odd

    2009-01-01

    The projects Xmath (Bringslid and Canessa, 2002) and dMath (Bringslid, de la Villa and Rodriguez, 2007) were supported by the European Commission in the so called Minerva Action (Xmath) and The Leonardo da Vinci programme (dMath). The Xmath eBook (Bringslid, 2006) includes algorithms into a wide range of undergraduate mathematical issues embedded…

  17. A New Approach to Ionospheric Delay Corrections in Single Frequency GPS Receivers

    DTIC Science & Technology

    1997-12-01

    is defined as the ionospheric point P as shown in Fig.3. - given the vertical electron content VEC in P, TEC is written as: TEC = VEC . secx (8...Cina and A. Manzino (Politecnico di Torino - Dipartimento di Georisorse e Territorio ) and J. Palacio Rodriguez (ROA - San Fernando, Spain). REFERENCES

  18. Always Running. La Vida Loca: Gang Days in L.A.

    ERIC Educational Resources Information Center

    Rodriguez, Luis J.

    This autobiographical narrative describes the early life of Luis J. Rodriguez, a journalist and poet who was immersed in the youth gang culture of Los Angeles (California). Framed by the story of the pull of the gang life for the poet's son, it recounts his experiences from his childhood on the United States-Mexico border through his family's…

  19. Investigation of Impurities in type-II InAs/GaSb Superlattices via Capacitance-Voltage Measurement

    DTIC Science & Technology

    2013-07-17

    Phys. Lett. 92, 071102 (2008). 17T. V. Chandrasekhar Rao, J. Antoszewski, L. Faraone , J. B. Rodriguez, E. Plis, and S. Krishna, Appl. Phys. Lett. 92...1993). 25G. A. Umana-Membreno, B. Klein, H. Kala, J. Antoszewski, N. Gautam, M. N. Kutty, E. Plis, S. Krishna, and L. Faraone , Appl. Phys. Lett. 101

  20. Securing Sub-Saharan Africa’s Maritime Environment: Lessons Learned from the Caribbean and Southeast Asia

    DTIC Science & Technology

    2009-06-01

    United States, but engagement ranged from begrudging or reluctant participation to 79 Jorge ...85 Jorge Rodriguez Beruff and Gerardo Cordero, “The Caribbean: The ‘Third Border’ and the War...Anti-Piracy Initiatives in Southeast Asia; Policy Formulation and the Coastal State Responses,” 491–2. 156 Bradford, 499–500. 157 Jovito Tamayo , “PCG

  1. A Portfolio of Outstanding Americans of Mexican Descent.

    ERIC Educational Resources Information Center

    Lelevier, Benjamin, Jr.

    A cross section of Mexican American achievement is presented in a portfolio of 37 portraits of outstanding Americans of Mexican descent. Drawn in black and white on heavy paper stock by Mr. David L. Rodriguez, the sketches are suitable for display purposes. With the likenesses are biographical sketches in both English and Spanish which were…

  2. Family Violence and Migrant Women: Implications for Practice. Migrant Clinicians Network Clinical Supplement.

    ERIC Educational Resources Information Center

    Rodriguez, Rachel; And Others

    1993-01-01

    This newsletter supplement is devoted to the theme of domestic violence affecting migrant women. It contains four articles describing programs providing violence prevention education to migrant women and children. "Family Violence and Migrant Women: Implications for Practice" (Rachel Rodriguez) discusses the social isolation of migrant women;…

  3. Funds of Relationality: Social Bonds and Science Learners

    ERIC Educational Resources Information Center

    Smardon, Regina

    2011-01-01

    In this response to Konstantinos Alexakos, Jayson K. Jones, and Victor H. Rodriguez, I will focus primarily on the importance of relationality for the development of a science learner identity. Along the way I will review (1) The cultural dynamics involved with the formation and sustenance of relationships in social life; (2) The methodological…

  4. Nemachtilli: The Spirit of Learning

    ERIC Educational Resources Information Center

    Rodriguez, Luis J.

    2005-01-01

    Luis J. Rodriguez believes that the spirit of learning is not nurtured or encouraged in schools because the spirit of teaching is absent. Learning is not just about books but it happens in all kind of ways that should be nurtured with spirit.

  5. Sal Adelante Mujer!: Support Group for Latina First-Year College Students

    ERIC Educational Resources Information Center

    Segura-Malady, Evelyn E.

    2014-01-01

    Latinas are at a disadvantage when it comes to earning a college degree, as is evidenced by the fact that they take longer to complete their degrees than Black, Asian, and white college students and have the lowest graduation rates in comparison to these respective groups (Fry, 2004; Fry, 2012; Rodriguez, Guido-Brito, Torres, & Talbot, 2000).…

  6. Using Supervised Learning Techniques for Diagnosis of Dynamic Systems

    DTIC Science & Technology

    2002-05-04

    Sisteinas Dinmicos: hacia una Caracterizaci6n correct behaviour. In those cases the fault is not detected. Other en el Nivel de Conocimiento . In proceedings...Rodriguez, Carlos J. Alonso y Q. Isaac Moro. Clasificaci6n de patrones temporales en sistemas dinimicos mediante Boosting y Alineamiento dinamico

  7. A Historical Omission

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2007-01-01

    For nearly a decade, Dr. Maggie Rivas-Rodriguez and a small army of students and volunteer colleagues around the country have been aggressively chasing and documenting a rapidly vanishing chapter of American history--the American Latino and Latina experience during World War II. Along the way, they recorded nearly 600 interviews of about two…

  8. 78 FR 36217 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ..., identified by Docket No. FEMA-B-1325, to Luis Rodriguez, Chief, Engineering Management Branch, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500 C Street SW... section 110 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a)....

  9. 78 FR 32678 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... notification. This final notice is issued in accordance with section 110 of the Flood Disaster Protection Act... Narragansett Town Hall, Engineering Department, 25 5th Avenue, Narragansett, RI 02882. Town of New Shoreham...

  10. 78 FR 32679 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ..., identified by Docket No. FEMA-B-1309, to Luis Rodriguez, Chief, Engineering Management Branch, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500 C Street SW... section 110 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a)....

  11. 78 FR 36222 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ..., identified by Docket No. FEMA-B-1326, to Luis Rodriguez, Chief, Engineering Management Branch, Federal..., Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500 C Street SW... section 110 of the Flood Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR 67.4(a)....

  12. 78 FR 20338 - Final Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Rodriguez, Chief, Engineering Management Branch, Federal Insurance and Mitigation Administration, FEMA, 500... Disaster Protection Act of 1973, 42 U.S.C. 4104, and 44 CFR part 67. FEMA has developed criteria for... Engineering Division, City County Building, 400 Main Street, Room 480, Knoxville, TN 37902. Town of...

  13. Mixing in Shear Coaxial Jets with and without Acoustics (Briefing Charts)

    DTIC Science & Technology

    2012-05-21

    Slides) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Ivett Leyva, Sophonias Teshome, Juan Rodriguez, Jeffrey ...setup – EC-4 Waveguide Coaxial Injector Piezo-Siren Direction of movement A B Thermocouple and P transducer Inner Chamber 1.50 1.51 1.52

  14. Comet 29P/SW1 outburst

    NASA Astrophysics Data System (ADS)

    Trigo-Rodriguez, Josep M.

    2008-10-01

    The present outburst experienced by this Centaur (#IAUC 8978) is the brightest detected since September 2004 [for more details see Trigo-Rodriguez et al. (2008) A&A485, pp. 599-606]. In the previously reported work the outburst frequency was established in 7.3 outbursts/year, typically reaching a +13 maximum magnitude or less.

  15. 76 FR 20800 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... support of an Airborne Intelligence and Surveillance System (AISS) for the Finland Ministry of Defense... Department of State by the applicant, publication of which could cause competitive harm to the United States... could cause competitive harm to the United States firm concerned. Sincerely, Miguel E. Rodriguez...

  16. Race--Social, Biological, or Lemonade?

    ERIC Educational Resources Information Center

    Carey, Gregory

    2006-01-01

    This paper presents comments on an article by R. L. Sternberg, E. L. Grigorenko, and K. K. Kidd and another article by H. Tang, T. Quertermous, B. Rodriguez, S. L. Kardia, X. Zhu, X., A. Brown, et al. (2005). On the day that the author of this paper reads Sternberg, Grigorenko, and Kidd's (January 2005) article on race, an article from the…

  17. The Role of ERK1/2 in the Progression of Anti-Androgen Resistance of MtDNA Deficient Prostate Cancer

    DTIC Science & Technology

    2012-03-01

    Gout I, Fry MJ, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature. 1994;370(6490):527-32. 27. McCubrey JA, Steelman LS...Science 1994; 266: 1719–1723. 25. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ et al. Phosphatidylinositol-3-OH kinase as

  18. Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

    PubMed Central

    Zhu, Hua; Xiong, Yi; Xia, Yunqiu; Zhang, Rong; Tian, Daiyin; Wang, Ting; Dai, Jihong; Wang, Lijia; Yao, Hongbing; Jiang, Hong; Yang, Ke; Liu, Enmei; Shi, Yujun; Fu, Zhou; Gao, Li; Zou, Lin

    2017-01-01

    The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS. PMID:28051154

  19. Acute Lung Injury Following Smoke Inhalation: Predictive Value of Sputum Biomarkers and Time Course of Lung Inflammation

    DTIC Science & Technology

    2007-05-01

    acute lung injury (ALI) and acute respiratory distress syndrome ( ARDS ). Criteria for diagnosing ALI and predicting...Rationale: Smoke inhalation victims are at high risk of developing acute respiratory distress syndrome ( ARDS ). Given the delay of 12 or more hours...Background: Although smoke inhalation injury victims frequently develop acute respiratory distress syndrome ( ARDS ), no early prognostic

  20. 10 CFR 20.1502 - Conditions requiring individual monitoring of external and internal occupational dose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the entire pregnancy, from radiation sources external to the body, a deep dose equivalent in excess of... likely to receive, in 1 year, an intake in excess of 10 percent of the applicable ALI(s) in table 1..., during the entire pregnancy, a committed effective dose equivalent in excess of 0.1 rem (1 mSv)....

  1. 10 CFR 20.1204 - Determination of internal exposure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... effective dose equivalent of 5 rems (0.05 Sv) (the stochastic ALI) is listed in parentheses in table 1 of appendix B to part 20. In this case, the licensee may, as a simplifying assumption, use the stochastic ALIs to determine committed effective dose equivalent. However, if the licensee uses the stochastic...

  2. Adaptability of Land Forces to 21st Century Security Challenges

    DTIC Science & Technology

    2008-05-01

    Stability” panel. From left, Gen-Maj Latif Faiziyev, Tajikistan; MG Ali al - Kaabi , UAE; and MG Ali Taleb, Yemen, discuss the Tajik DDR program...developed by al -Qaida and other terrorist groups. Second, natural disasters such as Cyclone Nargis, the Indonesian tsunami, major earthquakes and floods

  3. Spoken Word Recognition in Adolescents with Autism Spectrum Disorders and Specific Language Impairment

    ERIC Educational Resources Information Center

    Loucas, Tom; Riches, Nick; Baird, Gillian; Pickles, Andrew; Simonoff, Emily; Chandler, Susie; Charman, Tony

    2013-01-01

    Spoken word recognition, during gating, appears intact in specific language impairment (SLI). This study used gating to investigate the process in adolescents with autism spectrum disorders plus language impairment (ALI). Adolescents with ALI, SLI, and typical language development (TLD), matched on nonverbal IQ listened to gated words that varied…

  4. EO-1 Advanced Land Imager Modulation Transfer Functions

    DTIC Science & Technology

    2000-03-22

    has used a laser unequal-path interferometer ( LUPI ) to characterize the WFE of the ALI. They obtained interferograms at a dozen points distributed...MATED ZERNIKE POLYNOMIAL COEFFICIENTS OF WAVEFRONT ERRORS SSG, Inc. used a laser unequal-path interferometer ( LUPI ) to characterize the WFE of the ALI

  5. 77 FR 74126 - Airworthiness Directives; Bombardier, Inc. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... Maintenance Requirements Manual, PSM 1-84-7. The actions described in this service information are intended to... Limitations Items (ALI) Part 2, Bombardier Q400 Dash 8 Maintenance Requirements Manual, PSM 1-84-7. The... Items (ALI) Part 2, Bombardier Q400 Dash 8 Maintenance Requirements Manual, PSM 1-84-7. When this TR...

  6. Critical Evaluation of Air-Liquid Interface Exposure Devices for In Vitro Assessment of Atmospheric Pollutants

    EPA Science Inventory

    Exposure of cells to atmospheric pollutants at the air-liquid interface (ALI) is a more realistic approach than exposures of attached cells submerged in liquid medium. However, there is still limited understanding of the ideal ALI device design features that permit reproducible a...

  7. Evaluation of air-liquid interface exposure systems for in vitro assessment of airborne pollutants

    EPA Science Inventory

    Exposure of cells to airborne pollutants at the air-liquid interface (ALI) is a more realistic approach than exposures of submerged cells. The published literature, however, describes irreproducible and/or unrealistic experimental conditions using ALI systems. We have compared fi...

  8. Couple Conflict and Rope-a-Dope.

    ERIC Educational Resources Information Center

    Downing, Jerry; Harrison, Tom

    1993-01-01

    Draws analogy between Muhammad Ali's boxing technique of "rope-a-dope" and behavioral patterns frequently occurring in couple conflicts. Presents basics of Ali's technique as similar to fighting patterns of many couples. Suggests that this behavior may lead to physical violence. Describes use of analogy in working with couples. Presents strategies…

  9. Air–liquid interface enhances oxidative phosphorylation in intestinal epithelial cell line IPEC-J2

    PubMed Central

    Klasvogt, Sonja; Zuschratter, Werner; Schmidt, Anke; Kröber, Andrea; Vorwerk, Sandra; Wolter, Romina; Isermann, Berend; Wimmers, Klaus; Rothkötter, Hermann-Josef; Nossol, Constanze

    2017-01-01

    The intestinal porcine epithelial cell line IPEC-J2, cultured under the air–liquid interface (ALI) conditions, develops remarkable morphological characteristics close to intestinal epithelial cells in vivo. Improved oxygen availability has been hypothesised to be the leading cause of this morphological differentiation. We assessed oxygen availability in ALI cultures and examined the influence of this cell culture method on glycolysis and oxidative phosphorylation in IPEC-J2 using the submerged membrane culture (SMC) and ALI cultures. Furthermore, the role of HIF-1 as mediator of oxygen availability was analysed. Measurements of oxygen tension confirmed increased oxygen availability at the medium–cell interface and demonstrated reduced oxygen extraction at the basal compartment in ALI. Microarray analysis to determine changes in the genetic profile of IPEC-J2 in ALI identified 2751 modified transcripts. Further examinations of candidate genes revealed reduced levels of glycolytic enzymes hexokinase II and GAPDH, as well as lactate transporting monocarboxylate transporter 1 in ALI, whereas expression of the glucose transporter GLUT1 remained unchanged. Cytochrome c oxidase (COX) subunit 5B protein analysis was increased in ALI, although mRNA level remained at constant level. COX activity was assessed using photometric quantification and a three-fold increase was found in ALI. Quantification of glucose and lactate concentrations in cell culture medium revealed significantly reduced glucose levels and decreased lactate production in ALI. In order to evaluate energy metabolism, we measured cellular adenosine triphosphate (ATP) aggregation in homogenised cell suspensions showing similar levels. However, application of the uncoupling agent FCCP reduced ATP levels in ALI but not in SMC. In addition, HIF showed reduced mRNA levels in ALI. Furthermore, HIF-1α protein was reduced in the nuclear compartment of ALI when compared to SCM as confirmed by confocal microscopy

  10. Biomarkers in acute lung injury.

    PubMed

    Mokra, Daniela; Kosutova, Petra

    2015-04-01

    Acute respiratory distress syndrome (ARDS) and its milder form acute lung injury (ALI) may result from various diseases and situations including sepsis, pneumonia, trauma, acute pancreatitis, aspiration of gastric contents, near-drowning etc. ALI/ARDS is characterized by diffuse alveolar injury, lung edema formation, neutrophil-derived inflammation, and surfactant dysfunction. Clinically, ALI/ARDS is manifested by decreased lung compliance, severe hypoxemia, and bilateral pulmonary infiltrates. Severity and further characteristics of ALI/ARDS may be detected by biomarkers in the plasma and bronchoalveolar lavage fluid (or tracheal aspirate) of patients. Changed concentrations of individual markers may suggest injury or activation of the specific types of lung cells-epithelial or endothelial cells, neutrophils, macrophages, etc.), and thereby help in diagnostics and in evaluation of the patient's clinical status and the treatment efficacy. This chapter reviews various biomarkers of acute lung injury and evaluates their usefulness in diagnostics and prognostication of ALI/ARDS.

  11. Measuring allostatic load in the workforce: a systematic review

    PubMed Central

    MAUSS, Daniel; LI, Jian; SCHMIDT, Burkhard; ANGERER, Peter; JARCZOK, Marc N.

    2014-01-01

    The Allostatic Load Index (ALI) has been used to establish associations between stress and health-related outcomes. This review summarizes the measurement and methodological challenges of allostatic load in occupational settings. Databases of Medline, PubPsych, and Cochrane were searched to systematically explore studies measuring ALI in working adults following the PRISMA statement. Study characteristics, biomarkers and methods were tabulated. Methodological quality was evaluated using a standardized checklist. Sixteen articles (2003–2013) met the inclusion criteria, with a total of 39 (range 6–17) different variables used to calculate ALI. Substantial heterogeneity was observed in the number and type of biomarkers used, the analytic techniques applied and study quality. Particularly, primary mediators were not regularly included in ALI calculation. Consensus on methods to measure ALI in working populations is limited. Research should include longitudinal studies using multi-systemic variables to measure employees at risk for biological wear and tear. PMID:25224337

  12. The Sclerotic Scatter Limbal Arc Is More Easily Elicited under Mesopic Rather Than Photopic Conditions

    PubMed Central

    Denion, Eric; Lux, Anne-Laure; Mouriaux, Frédéric; Béraud, Guillaume

    2016-01-01

    Introduction We aimed to determine the limbal lighting illuminance thresholds (LLITs) required to trigger perception of sclerotic scatter at the opposite non-illuminated limbus (i.e. perception of a light limbal scleral arc) under different levels of ambient lighting illuminance (ALI). Material and Methods Twenty healthy volunteers were enrolled. The iris shade (light or dark) was graded by retrieving the median value of the pixels of a pre-determined zone of a gray-level iris photograph. Mean keratometry and central corneal pachymetry were recorded. Each subject was asked to lie down, and the ALI at eye level was set to mesopic values (10, 20, 40 lux), then photopic values (60, 80, 100, 150, 200 lux). For each ALI level, a light beam of gradually increasing illuminance was applied to the right temporal limbus until the LLIT was reached, i.e. the level required to produce the faint light arc that is characteristic of sclerotic scatter at the nasal limbus. Results After log-log transformation, a linear relationship between the logarithm of ALI and the logarithm of the LLIT was found (p<0.001), a 10% increase in ALI being associated with an average increase in the LLIT of 28.9%. Higher keratometry values were associated with higher LLIT values (p = 0.008) under low ALI levels, but the coefficient of the interaction was very small, representing a very limited effect. Iris shade and central corneal thickness values were not significantly associated with the LLIT. We also developed a censored linear model for ALI values ≤ 40 lux, showing a linear relationship between ALI and the LLIT, in which the LLIT value was 34.4 times greater than the ALI value. Conclusion Sclerotic scatter is more easily elicited under mesopic conditions than under photopic conditions and requires the LLIT value to be much higher than the ALI value, i.e. it requires extreme contrast. PMID:26964096

  13. Purification and characterization of a bifunctional alginate lyase from Pseudoalteromonas sp. SM0524.

    PubMed

    Li, Jian-Wei; Dong, Sheng; Song, Jie; Li, Chun-Bo; Chen, Xiu-Lan; Xie, Bin-Bin; Zhang, Yu-Zhong

    2011-01-21

    An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional alginate lyase aly-SJ02 secreted by strain SM0524 was purified. Aly-SJ02 had an apparent molecular mass of 32 kDa. The optimal temperature and pH of aly-SJ02 toward sodium alginate was 50 °C and 8.5, respectively. The half life period of aly-SJ02 was 41 min at 40 °C and 20 min at 50 °C. Aly-SJ02 was most stable at pH 8.0. N-terminal sequence analysis suggested that aly-SJ02 may be an alginate lyase of polysaccharide lyase family 18. Aly-SJ02 showed activities toward both polyG (α-l-guluronic acid) and polyM (β-D-mannuronic acid), indicating that it is a bifunctional alginate lyase. Aly-SJ02 had lower K(m) toward polyG than toward polyM and sodium alginate. Thin layer chromatography and ESI-MS analyses showed that aly-SJ02 mainly released dimers and trimers from polyM and alginate, and trimers and tetramers from polyG, which suggests that aly-SJ02 may be a good tool to produce dimers and trimers from alginate.

  14. Effect of inhaled nitric oxide on pulmonary hemodynamics after acute lung injury in dogs

    SciTech Connect

    Romand, J.A.; Pinsky, M.R.; Firestone, L.; Zar, H.A.; Lancaster, J.R. Jr. )

    1994-03-01

    Increased pulmonary vascular resistance (PVR) and mismatch in ventilation-to-perfusion ratio characterize acute lung injury (ALI). Pulmonary arterial pressure (Ppa) decreases when nitric oxide (NO) is inhaled during hypoxic pulmonary vasoconstriction (HPV); thus NO inhalation may reduce PVR and improve gas exchange in ALI. The authors studied the hemodynamic and gas exchange effects of NO inhalation during HPV and then ALI in eight anesthetized open-chest mechanically ventilated dogs. Right atrial pressure, Ppa, and left ventricular and arterial pressures were measured, and cardiac output was estimated by an aortic flow probe. Shunt and dead space were also estimated. The effect of 5-min exposures to 0, 17, 28, 47, and 0 ppm inhaled NO was recorded during hyperoxia, hypoxia, and oleic acid-induced ALI. During ALI, partial [beta]-adrenergic blockage (propanolol, 0.15 mg/kg iv) was induced and 74 ppm NO was inhaled. Nitrosylhemoglobin (NO-Hb) and methemoglobin (MetHb) levels were measured. During hyperoxia, NO inhalation had no measurable effects. Hypoxia increased Ppa and calculated PVR, both of which decreased with 17 ppm NO. ALI decreased arterial Po[sub 2] and increased airway pressure, shunt, and dead space ventilation. Ppa and PVR were greater during ALI than during hyperoxia. NO inhalation had no measurable effect during ALI before or after [beta]-adrenergic blockage. MetHb remained low, and NO-Hb was unmeasurable. Bolus infusion of nitroglycerin (15 [mu]g) induced an immediate decrease in Ppa and PVR during ALI. Short-term NO inhalation does not affect PVR or gas exchange in dogs with oleic acid-induced ALI, nor does it increase NO-Hb or MetHb. In contrast, NO can diminish hypoxia-induced elevations in pulmonary vascular tone. These data suggest that NO inhalation selectively dilates the pulmonary circulation and specifically reduces HPV but not oleic acid-induced increases in pulmonary vasomotor tone. 28 refs., 3 figs., 2 tabs.

  15. A streamlined approach for assessing the Allostatic Load Index in industrial employees.

    PubMed

    Mauss, Daniel; Jarczok, Marc N; Fischer, Joachim E

    2015-01-01

    Work stress is common and can lead to various bodily dysfunctions. The Allostatic Load Index (ALI) is a tool to measure the wear and tear of the body caused by chronic stress. This cross-sectional study aimed to explore the association of work-related stress and ALI in German industrial employees. A short form ALI should be developed for practical use of company physicians. In this exploration of an industrial cohort (n = 3797; 79.3% male), work stress was measured by the effort-reward imbalance (ERI) questionnaire in 2009-2011. ALI was calculated using 15 variables including anthropometric data, heart rate variability, as well as blood and urine samples based on predefined subclinical cut-off values. Differences in ALI related to low (≤1) and high (>1) ERI categories were tested. Logistic regression models estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between ALI and work stress controlling for multiple confounders. Employees exposed to high work stress showed higher ALI scores (p < 0.001) compared to those with low stress levels. In multivariable models, ALI was associated with work stress (OR 1.19 [95% CI: 1.00, 1.42]; p < 0.05) following adjustment for a range of potential confounders. By reducing ALI parameters to five variables this association increased modestly and remained statistically significant (OR 1.27 [95% CI: 1.05, 1.54]; p < 0.05). The results indicate that work stress is associated with ALI in German industrial employees. A short form index seems to be a promising approach for occupational health practitioners. The results should be validated in further longitudinal explorations defining a standard set of variables including gender-related thresholds.

  16. Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.

    PubMed

    Zhang, Yong; Li, Xiru; Grailer, Jamison J; Wang, Na; Wang, Mingming; Yao, Jianfei; Zhong, Rui; Gao, George F; Ward, Peter A; Tan, Dun-Xian; Li, Xiangdong

    2016-05-01

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders, and there are currently no Food and Drug Administration-approved drug therapies. Melatonin is a well-known anti-inflammatory molecule, which has proven to be effective in ALI induced by many conditions. Emerging studies suggest that the NLRP3 inflammasome plays a critical role during ALI. How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear. In this study, using an LPS-induced ALI mouse model, we found intratracheal (i.t.) administration of melatonin markedly reduced the pulmonary injury and decreased the infiltration of macrophages and neutrophils into lung. During ALI, the NLRP3 inflammasome is significantly activated with a large amount of IL-1β and the activated caspase-1 occurring in the lung. Melatonin inhibits the activation of the NLRP3 inflammasome by both suppressing the release of extracellular histones and directly blocking histone-induced NLRP3 inflammasome activation. Notably, i.t. route of melatonin administration opens a more efficient therapeutic approach for treating ALI.

  17. Analysis of lead content in herbal preparations in Malaysia.

    PubMed

    Ang, H H; Lee, E L; Matsumoto, K

    2003-08-01

    In Malaysia, the phase 3 registration for traditional medicines was implemented on 1 January 1992 under the Control of Drugs and Cosmetics Regulation 1984, emphasizing quality, efficacy and safety (including the detection of the presence of heavy metals) in all pharmaceutical dosage forms of traditional medicine preparations. Therefore, a total of 100 products in various pharmaceutical dosage forms of a herbal preparation, were analysed for lead content using atomic absorption spectrophotometer. Results showed that 8% (eight products) possessed 10.64-20.72 ppm of lead, and therefore, do not comply with the quality requirement for traditional medicines in Malaysia. One of these products, M-Tongkat Ali (exhibited 10.64 +/-0.37 ppm of lead), was in fact already registered with the DCA Malaysia. The rest, Sukarno Tongkat Ali, Eurycoma Madu, Super Pill Tongkat Ali, Force Pill Tongkat Ali, Tender Pill Tongkat Ali, Super Pill Tongkat Ali Plus and Great Pill Tongkat Ali Plus have not registered with the DCA Malaysia and exhibited 12.24-20.72 ppm of lead. Although this study showed that only 92% of the products complied with the quality requirement for traditional medicines in Malaysia, however, they cannot be assumed safe from lead contamination because of batch-to-batch inconsistency.

  18. Simvastatin Reduces Endotoxin-Induced Acute Lung Injury by Decreasing Neutrophil Recruitment and Radical Formation

    PubMed Central

    Grommes, Jochen; Vijayan, Santosh; Drechsler, Maik; Hartwig, Helene; Mörgelin, Matthias; Dembinski, Rolf; Jacobs, Michael; Koeppel, Thomas Andreas; Binnebösel, Marcel; Weber, Christian; Soehnlein, Oliver

    2012-01-01

    Introduction Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI also on neutrophil effector functions. Methods C57Bl/6 mice were exposed to aerosolized LPS (500 µg/ml) for 30 min. The count of alveolar, interstitial, and intravasal neutrophils were assessed 4 h later by flow cytometry. Lung permeability changes were assessed by FITC-dextran clearance and albumin content in the BAL fluid. In vitro, we analyzed the effect of simvastatin on neutrophil adhesion, degranulation, apoptosis, and formation of reactive oxygen species. To monitor effects of simvastatin on bacterial clearance we performed phagocytosis and bacterial killing studies in vitro as well as sepsis experiments in mice. Results Simvastatin treatment before and after onset of ALI reduces neutrophil influx into the lung as well as lung permeability indicating the protective role of simvastatin in ALI. Moreover, simvastatin reduces the formation of ROS species and adhesion of neutrophils without affecting apoptosis, bacterial phagocytosis and bacterial clearance. Conclusion Simvastatin reduces recruitment and activation of neutrophils hereby protecting from LPS-induced ALI. Our results imply a potential role for statins in the management of ALI. PMID:22701728

  19. In vivo microscopy in a porcine model of acute lung injury.

    PubMed

    Bickenbach, Johannes; Czaplik, Michael; Dembinski, Rolf; Pelosi, Paolo; Schroeder, Wolfgang; Marx, Gernot; Rossaint, Rolf

    2010-07-31

    Regional inhomogeneity and alveolar mechanics in a porcine model of acute lung injury (ALI) was evaluated using confocal laser scanning microscopy (CLSM). CLSM was performed through thoracic windows of the upper and lower lobes. Image quantification was conducted by use of a volume air index (VAI). Twelve anesthetized, mechanically ventilated pigs were randomized to non-injury (control group, n = 6) or ALI induced by surfactant depletion (ALI group, n = 6). CLSM was performed at baseline, after 1 h at 5 mbar and after 2 h at 15 mbar positive end-expiratory pressure (PEEP). Haemodynamics, respiratory mechanics and calculation of pulmonary ventilation-perfusion distribution by MIGET were determined. At baseline, VAI was not different. In the upper lobes, VAI significantly decreased in ALI compared to control group, with no changes after PEEP application. In the lower lobes, VAI significantly decreased in ALI compared to control group. Incremental PEEP significantly increased VAI in ALI, but not in control group. Haemodynamics were significantly compromised in the ALI group. A significant deterioration in oxygenation and ventilation-perfusion distribution could be seen being restored after PEEP adjustment. The VAI may help to assess regional inhomogeneity of the acutely injured lung.

  20. Subsurface Imaging by UWB Radar: Application to Humanitarian Demining in Cambodia

    NASA Astrophysics Data System (ADS)

    Sato, Motoyuki

    Ground Penetrating Radar (GPR) has been widely used applications which include detection of subsurface facilities, concrete inspection and archaeology. Among these applications, humanitarian demining is still difficult task. Since 2002, we have developed a new hand-held land mine detection dual-sensor ALIS. ALIS is equipped with a metal detector and a GPR, and it has a sensor tracking system, which can record the GPR and Metal detector signal with its location. ALIS can process the data and is used for image re-construction by migration processing. ALIS is the only one mine detection system in the world which can visualize the GPR image by hand scanning. We found that the migration processing can reduce the clutter and gives us clear images of buried mines. After several tests of ALIS in mine affected courtiers, operation of ALIS in mine fields in Cambodia started in summer 2009. Two sets of ALIS have been operated in Cambodia and more than 77 antipersonnel mines have been detected and 137,000m2 farmland was cleaned.

  1. Genetic Determinants and Ethnic Disparities in Sepsis-associated Acute Lung Injury

    PubMed Central

    Barnes, Kathleen C.

    2005-01-01

    Acute lung injury (ALI) is a common and devastating illness that occurs in the context of sepsis and other systemic inflammatory disorders. In systemic illnesses like sepsis, only a subset of patients develops ALI even when pathologic stimuli are apparently equivalent, suggesting that there are genetic features that may influence its onset. Considerable obstacles in defining the exact nature of the pathogenesis of ALI include substantial phenotypic variance, incomplete penetrance, complex gene–environment interactions and a strong potential for locus heterogeneity. Moreover, ALI arises in a critically ill population with diverse precipitating factors and appropriate controls that best match the reference population have not been agreed upon. The sporadic nature of ALI precludes conventional approaches such as linkage mapping for the elucidation of candidate genes, but tremendous progress has been made in combining robust, genomic tools such as high-throughput, expression profiling with case-control association studies in well characterized populations. Similar to trends observed in common, complex traits such as hypertension and diabetes, some of these studies have highlighted differences in allelic variant frequencies between European American and African American ALI patients for novel genes which may explain, in part, the complex interplay between ethnicity, sepsis and the development of ALI. In trying to understand the basis for contemporary differences in allelic frequency, which may lead to differences in susceptibility, the potential role of positive selection for genetic variants in ancestral populations is considered. PMID:16222037

  2. Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice

    PubMed Central

    Soeiro-Pereira, Paulo V.; Gomes, Eliane; Neto, Antonio Condino; D' Império Lima, Maria R.; Alvarez, José M.; Portugal, Silvia; Epiphanio, Sabrina

    2016-01-01

    Malaria remains one of the greatest burdens to global health, causing nearly 500,000 deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We have previously shown that a proportion of DBA/2 mice infected with Plasmodium berghei ANKA (PbA) develop ALI/ARDS and that these mice recapitulate various aspects of the human syndrome, such as pulmonary edema, hemorrhaging, pleural effusion and hypoxemia. Herein, we investigated the role of neutrophils in the pathogenesis of malaria-associated ALI/ARDS. Mice developing ALI/ARDS showed greater neutrophil accumulation in the lungs compared with mice that did not develop pulmonary complications. In addition, mice with ALI/ARDS produced more neutrophil-attracting chemokines, myeloperoxidase and reactive oxygen species. We also observed that the parasites Plasmodium falciparum and PbA induced the formation of neutrophil extracellular traps (NETs) ex vivo, which were associated with inflammation and tissue injury. The depletion of neutrophils, treatment with AMD3100 (a CXCR4 antagonist), Pulmozyme (human recombinant DNase) or Sivelestat (inhibitor of neutrophil elastase) decreased the development of malaria-associated ALI/ARDS and significantly increased mouse survival. This study implicates neutrophils and NETs in the genesis of experimentally induced malaria-associated ALI/ARDS and proposes a new therapeutic approach to improve the prognosis of severe malaria. PMID:27926944

  3. Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation

    PubMed Central

    Liu, Tian; Zhou, Yong; Li, Ping; Duan, Jia-Xi; Liu, Yong-Ping; Sun, Guo-Ying; Wan, Li; Dong, Liang; Fang, Xiang; Jiang, Jian-Xin; Guan, Cha-Xiang

    2016-01-01

    Acute lung injury (ALI) is associated with high mortality and uncontrolled inflammation plays a critical role in ALI. TREM-1 is an amplifier of inflammatory response, and is involved in the pathogenesis of many infectious diseases. NLRP3 inflammasome is a member of NLRs family that contributes to ALI. However, the effect of TREM-1 on NLRP3 inflammasome and ALI is still unknown. This study aimed to determine the effect of TREM-1 modulation on LPS-induced ALI and activation of the NLRP3 inflammasome. We showed that LR12, a TREM-1 antagonist peptide, significantly improved survival of mice after lethal doses of LPS. LR12 also attenuated inflammation and lung tissue damage by reducing histopathologic changes, infiltration of the macrophage and neutrophil into the lung, and production of the pro-inflammatory cytokine, and oxidative stress. LR12 decreased expression of the NLRP3, pro-caspase-1 and pro-IL-1β, and inhibited priming of the NLRP3 inflammasome by inhibiting NF-κB. LR12 also reduced the expression of NLRP3 and caspase-1 p10 protein, and secretion of the IL-1β, inhibited activation of the NLRP3 inflammasome by decreasing ROS. For the first time, these data show that TREM-1 aggravates inflammation in ALI by activating NLRP3 inflammasome, and blocking TREM-1 may be a potential therapeutic approach for ALI. PMID:28004759

  4. Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

    PubMed Central

    Liu, Shuai; Su, Xiaoli; Pan, Pinhua; Zhang, Lemeng; Hu, Yongbin; Tan, Hongyi; Wu, Dongdong; Liu, Ben; Li, Haitao; Li, Haosi; Li, Yi; Dai, Minhui; Li, Yuanyuan; Hu, Chengping; Tsung, Allan

    2016-01-01

    Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated immune responses and tissue injury. In this study, we investigated the role of NETs in lipopolysaccharide (LPS)-mediated acute lung injury (ALI) and assessed the use of DNase I, for the treatment of ALI. Additionally, we focused on the controversial issue of whether LPS directly induces NETs release in vitro. NETs formation was detected in murine ALI tissue in vivo and was associated with increased NETs markers, citrullinated-histone H3 tissue levels and NET-DNA levels in BALF. Treatment with DNase I significantly degraded NETs and reduced citrullinated-histone H3 levels, which protected against ALI and ameliorated pulmonary oedema and total protein in BALF. In addition, DNase I significantly reduced IL-6 and TNF-α levels in plasma and BALF. In vitro, LPS-activated platelets rather than LPS alone efficiently induced NETs release. In conclusion, NETs formed during LPS-induced ALI, caused organ damage and initiated the inflammatory response. NETs degradation by DNase I promoted NET-protein clearance and protected against ALI in mice; thus, DNase I may be a new potential adjuvant for ALI therapy. Specifically, LPS induced NETs formation in an indirect manner via platelets activation. PMID:27849031

  5. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury.

    PubMed

    Bosmann, Markus; Grailer, Jamison J; Ruemmler, Robert; Russkamp, Norman F; Zetoune, Firas S; Sarma, J Vidya; Standiford, Theodore J; Ward, Peter A

    2013-12-01

    We investigated how complement activation promotes tissue injury and organ dysfunction during acute inflammation. Three models of acute lung injury (ALI) induced by LPS, IgG immune complexes, or C5a were used in C57BL/6 mice, all models requiring availability of both C5a receptors (C5aR and C5L2) for full development of ALI. Ligation of C5aR and C5L2 with C5a triggered the appearance of histones (H3 and H4) in bronchoalveolar lavage fluid (BALF). BALF from humans with ALI contained H4 histone. Histones were absent in control BALF from healthy volunteers. In mice with ALI, in vivo neutralization of H4 with IgG antibody reduced the intensity of ALI. Neutrophil depletion in mice with ALI markedly reduced H4 presence in BALF and was highly protective. The direct lung damaging effects of extracellular histones were demonstrated by airway administration of histones into mice and rats (Sprague-Dawley), which resulted in ALI that was C5a receptor-independent, and associated with intense inflammation, PMN accumulation, damage/destruction of alveolar epithelial cells, together with release into lung of cytokines/chemokines. High-resolution magnetic resonance imaging demonstrated lung damage, edema and consolidation in histone-injured lungs. These studies confirm the destructive C5a-dependent effects in lung linked to appearance of extracellular histones.

  6. A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma

    PubMed Central

    Gossmann, Jennifer; Stolte, Manfred; Lohoff, Michael; Yu, Philipp; Moll, Roland; Finkernagel, Florian; Garn, Holger; Brendel, Cornelia; Bittner, Alwina; Neubauer, Andreas; Huynh, Minh Q.

    2016-01-01

    Gastric mucosa-associated lymphoid tissue (MALT) lymphomas develop from a chronic Helicobacter infection. Phospholipase C gamma 2 (PLCG2) is important for B-cell survival and proliferation. We used BALB/c mice with a gain-of-function mutation in the Plcg2 gene (Ali5) to analyze its role in the development of gastric MALT lymphoma. Heterozygous BALB/c Plcg2Ali5/+ and wildtype (WT) mice were infected with Helicobacter felis (H. felis) and observed up to 16 months for development of gastric MALT lymphomas. In contrast to our initial hypothesis, Plcg2Ali5/+ mice developed MALT lymphomas less frequently than their WT littermates after long-term infection of 16 months. Infected Plcg2Ali5/+ mice showed downregulation of proinflammatory cytokines and decreased H. felis-specific IgG1 and IgG2a antibody responses. These results suggested a blunted immune response of Plcg2Ali5/+ mice towards H. felis infection. Intriguingly, Plcg2Ali5/+ mice harboured higher numbers of CD73 expressing regulatory T cells (Tregs), possibly responsible for impaired immune response towards Helicobacter infection. We suggest that Plcg2Ali5/+ mice may be protected from developing gastric MALT lymphomas as a result of elevated Treg numbers, reduced response to H. felis and decrease of proinflammatory cytokines. PMID:26966907

  7. Discovery of a Novel Alginate Lyase from Nitratiruptor sp. SB155-2 Thriving at Deep-sea Hydrothermal Vents and Identification of the Residues Responsible for Its Heat Stability.

    PubMed

    Inoue, Akira; Anraku, Moe; Nakagawa, Satoshi; Ojima, Takao

    2016-07-22

    Extremophiles are expected to represent a source of enzymes having unique functional properties. The hypothetical protein NIS_0185, termed NitAly in this study, was identified as an alginate lyase-homolog protein in the genomic database of ϵ-Proteobacteria Nitratiruptor sp. SB155-2, which was isolated from deep-sea hydrothermal vents at a water depth of 1,000 m. Among the characterized alginate lyases in the polysaccharide lyase family 7 (PL-7), the amino acid sequence of NitAly showed the highest identity (39%) with that of red alga Pyropia yezoensis alginate lyase PyAly. Recombinant NitAly (rNitAly) was successfully expressed in Escherichia coli Purified rNitAly degraded alginate in an endolytic manner. Among alginate block types, polyM was preferable to polyG and polyMG as a substrate, and its end degradation products were mainly tri-, tetra-, and penta-saccharides. The optimum temperature and pH values were 70 °C and around 6, respectively. A high concentration of NaCl (0.8-1.4 m) was required for maximum activity. In addition, a 50% loss of activity was observed after incubation at 67 °C for 30 min. Heat stability was decreased in the presence of 5 mm DTT, and Cys-80 and Cys-232 were identified as the residues responsible for heat stability but not lyase activity. Introducing two cysteines into PyAly based on homology modeling using Pseudomonas aeruginosa alginate lyase PA1167 as the template enhanced its heat stability. Thus, NitAly is a functional alginate lyase, with its unique optimum conditions adapted to its environment. These insights into the heat stability of NitAly could be applied to improve that of other PL-7 alginate lyases.

  8. Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury

    PubMed Central

    Ma, Shwu-Fan; Xie, Lishi; Pino-Yanes, Maria; Sammani, Saad; Wade, Michael S.; Letsiou, Eleftheria; Siegler, Jessica; Wang, Ting; Infusino, Giovanni; Kittles, Rick A.; Flores, Carlos; Zhou, Tong; Prabhakar, Bellur S.; Moreno-Vinasco, Liliana; Villar, Jesus; Jacobson, Jeffrey R.; Dudek, Steven M.

    2011-01-01

    The role of thyroid hormone metabolism in clinical outcomes of the critically ill remains unclear. Using preclinical models of acute lung injury (ALI), we assessed the gene and protein expression of type 2 deiodinase (DIO2), a key driver for synthesis of biologically active triiodothyronine, and addressed potential association of DIO2 genetic variants with ALI in a multiethnic cohort. DIO2 gene and protein expression levels in murine lung were validated by microarrays and immunoblotting. Lung injury was assessed by levels of bronchoalveolar lavage protein and leukocytes. Single-nucleotide polymorphisms were genotyped and ALI susceptibility association assessed. Significant increases in both DIO2 gene and D2 protein expression were observed in lung tissues from murine ALI models (LPS- and ventilator-induced lung injury), with expression directly increasing with the extent of lung injury. Mice with reduced levels of DIO2 expression (by silencing RNA) demonstrated reduced thyroxine levels in plasma and increased lung injury (increased bronchoalveolar lavage protein and leukocytes), suggesting a protective role for DIO2 in ALI. The G (Ala) allele of the Thr92Ala coding single-nucleotide polymorphism (rs225014) was protective in severe sepsis and severe sepsis–associated ALI after adjustments for age, sex, and genetic ancestry in a logistic regression model in European Americans. Our studies indicate that DIO2 is a novel ALI candidate gene, the nonsynonymous Thr92Ala coding variant of which confers ALI protection. Increased DIO2 expression may dampen the ALI inflammatory response, thereby strengthening the premise that thyroid hormone metabolism is intimately linked to the integrated response to inflammatory injury in critically ill patients. PMID:21685153

  9. Novel Polymorphisms in the Myosin Light Chain Kinase Gene Confer Risk for Acute Lung Injury

    PubMed Central

    Gao, Li; Grant, Audrey; Halder, Indrani; Brower, Roy; Sevransky, Jonathan; Maloney, James P.; Moss, Marc; Shanholtz, Carl; Yates, Charles R.; Meduri, Gianfranco Umberto; Shriver, Mark D.; Ingersoll, Roxann; Scott, Alan F.; Beaty, Terri H.; Moitra, Jaideep; Ma, Shwu Fan; Ye, Shui Q.; Barnes, Kathleen C.; Garcia, Joe G. N.

    2006-01-01

    The genetic basis of acute lung injury (ALI) is poorly understood. The myosin light chain kinase (MYLK) gene encodes the nonmuscle myosin light chain kinase isoform, a multifunctional protein involved in the inflammatory response (apoptosis, vascular permeability, leukocyte diapedesis). To examine MYLK as a novel candidate gene in sepsis-associated ALI, we sequenced exons, exon–intron boundaries, and 2 kb of 5′ UTR of the MYLK, which revealed 51 single-nucleotide polymorphisms (SNPs). Potential association of 28 MYLK SNPs with sepsis-associated ALI were evaluated in a case-control sample of 288 European American subjects (EAs) with sepsis alone, subjects with sepsis-associated ALI, or healthy control subjects, and a sample population of 158 African American subjects (AAs) with sepsis and ALI. Significant single locus associations in EAs were observed between four MYLK SNPs and the sepsis phenotype (P < 0.001), with an additional SNP associated with the ALI phenotype (P = 0.03). A significant association of a single SNP (identical to the SNP identified in EAs) was observed in AAs with sepsis (P = 0.002) and with ALI (P = 0.01). Three sepsis risk-conferring haplotypes in EAs were defined downstream of start codon of smooth muscle MYLK isoform, a region containing putative regulatory elements (P < 0.001). In contrast, multiple haplotypic analyses revealed an ALI-specific, risk-conferring haplotype at 5′ of the MYLK gene in both European and African Americans and an additional 3′ region haplotype only in African Americans. These data strongly implicate MYLK genetic variants to confer increased risk of sepsis and sepsis-associated ALI. PMID:16399953

  10. Transmission Dynamics of Visceral Leishmaniasis in the Indian Subcontinent – A Systematic Literature Review

    PubMed Central

    Boelaert, Marleen; Matlashewski, Greg; Mondal, Dinesh; Arana, Byron; Kroeger, Axel; Olliaro, Piero

    2016-01-01

    Background As Bangladesh, India and Nepal progress towards visceral leishmaniasis (VL) elimination, it is important to understand the role of asymptomatic Leishmania infection (ALI), VL treatment relapse and post kala-azar dermal leishmaniasis (PKDL) in transmission. Methodology/ Principal Finding We reviewed evidence systematically on ALI, relapse and PKDL. We searched multiple databases to include studies on burden, risk factors, biomarkers, natural history, and infectiveness of ALI, PKDL and relapse. After screening 292 papers, 98 were included covering the years 1942 through 2016. ALI, PKDL and relapse studies lacked a reference standard and appropriate biomarker. The prevalence of ALI was 4–17-fold that of VL. The risk of ALI was higher in VL case contacts. Most infections remained asymptomatic or resolved spontaneously. The proportion of ALI that progressed to VL disease within a year was 1.5–23%, and was higher amongst those with high antibody titres. The natural history of PKDL showed variability; 3.8–28.6% had no past history of VL treatment. The infectiveness of PKDL was 32–53%. The risk of VL relapse was higher with HIV co-infection. Modelling studies predicted a range of scenarios. One model predicted VL elimination was unlikely in the long term with early diagnosis. Another model estimated that ALI contributed to 82% of the overall transmission, VL to 10% and PKDL to 8%. Another model predicted that VL cases were the main driver for transmission. Different models predicted VL elimination if the sandfly density was reduced by 67% by killing the sandfly or by 79% by reducing their breeding sites, or with 4–6y of optimal IRS or 10y of sub-optimal IRS and only in low endemic setting. Conclusion/ Significance There is a need for xenodiagnostic and longitudinal studies to understand the potential of ALI and PKDL as reservoirs of infection. PMID:27490264

  11. Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

    PubMed Central

    Lu, Lunjie; Zhou, Jun; Zhang, Jingying; Che, Jun; Jiao, Yang; Zhang, Yusong

    2016-01-01

    Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI. PMID:27274751

  12. Civil-Military Relations in Iraq (1921-2006): An Introductory Survey

    DTIC Science & Technology

    2006-05-01

    and the officers, along with Rashid Ali himself, fled to Iran leaving a vacuum of power that was filled by the mayor Baghdad, Arshad al-‘Umari, who...Ghadir; the day Prophet Muhammad appointed Ali for the caliphate.[13] Once again the Shi’a got their share in symbolism and the Sunnis carried the...next major attempt to topple the government, generally known as the Rashid Ali coup. On April 1, 1941 the Iraqi cabinet under Prime Minister Taha al

  13. JPRS Report, Near East & South Asia

    DTIC Science & Technology

    2007-11-02

    that outside forces do not take advantage of the situation and strike Iraq. NEAR EAST JPRS-NEA-90-050 14 September 1990 ’ Ali -al-Din Salih...AL-THA WR1 in Arabic 14 Jul 90 pp 4-5 [Interview with Colonel Doctor Husayn ’ Ali Hasan, director of the Armed Forces’ Political Guidance and Morale...become a staunch and fundamental guarantor of the unity state. That is why we were fortunate to obtain this interview with Col. Dr. Husayn ’ Ali Hasan

  14. Smoke Inhalation in a Rural Emergency Setting: A Simulation Session

    PubMed Central

    Jong, Robert; Krustev, Eugene; Heroux, Aron

    2016-01-01

    Smoke inhalation-associated lung injuries (SI-ALI) present multiple challenges to the rural emergency department, and they require timely and appropriate management to prevent significant mortality and morbidity. In this report, we outline an adaptable simulation of an SI-ALI patient that is designed for use in a rural emergency department. The aim of this simulation is to better equip clinicians and emergency department staff who may encounter SI-ALI in rural settings. The case is suitable for resident doctors and emergency department staff. PMID:27774354

  15. Portable Low-Volume Therapy for Severe Blood Loss

    DTIC Science & Technology

    2014-06-01

    neuroprotective aspects of melatonin using the specific melatonin receptor antagonist luzindole in hibernating thirteen-lined ground squirrels... Hibernating mammals show natural neuroprotection and can provide additional clues on how we can improve the current BHB/M blood loss therapy. This data was...Schwartz, C., Perez de Lara Rodriguez, C.E., and Andrews, M.T. (2013). Melatonin as a protective component of the hibernation -based blood loss

  16. Insertion of Guest Molecules into a Mixed Ligand Metal-Organic Framework via Single-Crystal-to-Single Crystal Guest Exchange

    DTIC Science & Technology

    2014-07-01

    Insertion of Guest Molecules into a Mixed Ligand Metal−Organic Framework via Single-Crystal-to-Single- Crystal Guest Exchange by Lily Giri...Research Laboratory Aberdeen Proving Ground, MD 21005-5069 ARL-TR-7004 July 2014 Insertion of Guest Molecules into a Mixed Ligand Metal−Organic...Framework via Single-Crystal-to-Single- Crystal Guest Exchange Lily Giri, Rose Pesce-Rodriguez, Shashi P Karna, and Nirupam J Trivedi Weapons

  17. 78 FR 47492 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant to Executive Order 12978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    .... 11167762 (Colombia) (individual) . 4. LOPEZ RODRIGUEZ, Walter, c/o CARMILE INVERSIONES LOPEZ Y CIA. S.C.A... QUILICHAO S.A. & CIA S.C.A., Cali, Colombia; Carrera 66 No. 10-36, Cali, Colombia; Carrera 121 No. 13-76...) . Entities 1. CARMILE INVERSIONES LOPEZ Y CIA. S.C.A. (f.k.a. COMERCIALIZADORA CARMILE Y CIA. S.C.A.;...

  18. Populism in Latin America

    DTIC Science & Technology

    2009-03-20

    October 17, 2003 - June 6, 2005) and Eduardo Rodríguez Veltzé (June 9, 2005 - January 22, 2006).14 The current President of Ecuador, Rafael Correa ...took him 2 years to rise from instructor to his current position as Ecuadorian President. Before Rafael Correa in Ecuador there were several...Adolfo Rodriguez Saa (December 23 -- 30, 2001), Eduardo Oscar Camaño (December 31, 2001 – January 2, 2002), Eduardo Alberto Duhalde (January 2, 2002 – May

  19. A Test Fixture for Detecting the Presence of Water in Buoyant Cables

    DTIC Science & Technology

    1990-06-14

    Rodriguez Submarine Electromagnetic Systems Department DTIC ELECTFF MAY 2 7 1993,A Naval Underwater Systems Center New London, Connecticut / Newport, Rhode...Investigator C.E. Odams. The NUSC Program Manager is A.R. Susi, Code 34292. The spcisoring activity is SPAWAR PMW- 153-2; Project Manager Michael Sheehan... Systems Branch, along with Messrs. Craig L. Flynn, Eric von Winkle and Phillip Watrous of the Pressure Lab for their assistance in the measurements

  20. Underpotential Deposition of Silver on Pt(111). Part 1. Concentration Dependence

    DTIC Science & Technology

    1990-01-01

    AD-A236 692 Underpotential Deposition of Silver on Pt(111): Part I. Concentration Dependence r T ~.J.F. Rodriguez, D.L. Taylor and H.D. Abruhla* EL...dependence of the underpotential deposition of silver on well-defined Pt(111) electrodes. Electrochemical as well as ultra high vacuum surface...silver are deposited at underpotentials but the stability of the second layer is a strong function of the silver ion concentration in solution. When

  1. Design and Measurements of a Hybrid RF-MEMS Reconfigurable Loop Antenna on a Flexible Substrate (PREPRINT)

    DTIC Science & Technology

    2010-06-01

    AFRL-RY-WP-TP-2010-1147 DESIGN AND MEASUREMENTS OF A HYBRID RF-MEMS RECONFIGURABLE LOOP ANTENNA ON A FLEXIBLE SUBSTRATE (PREPRINT) Nelson... Antenna on a Flexible Substrate Nelson Sepulveda(1), Dimitrios E. Anagnostou* (2), Rafael A. Rodriguez-Solis(1), and John L. Ebel(3) (1... antenna was designed, fabricated (on a flexible substrate) and measured. The design concepts and measurement results are presented and discussed

  2. Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B cell Autoreactivity. Addendum

    DTIC Science & Technology

    2012-07-01

    14. ABSTRACT Systemic lupus erythematosus is an autoimmune disease that occurs preferentially in women. We have developed a murine model...4 Introduction: There is abundant clinical data that estrogen can increase risk of developing systemic lupus erythematosus (SLE) and disease...Kawabata, D., Pinto-Rodriguez, D., Grimaldi, C. and Diamond B. Hormonal regulator of B cell function and systemic lupus erythematosus . Lupus 17:528

  3. An Oral DNA Vaccine Encoding Endoglin Eradicates Breast Tumors by Blocking Their Blood Supply

    DTIC Science & Technology

    2006-05-01

    Angiogenesis and Protect Against Growth of Breast Cancer Metastases 91 [24] R. Xiang, H.N. Lode, T.H. Chao , J.M. Ruehlmann, C.S. Dol- man, F. Rodriguez, J.L...1-0562 (to R.X.) and EMD -Lexigen Research Center Billerica, MA grant SFP 1330 (to R.A.R). This is The Scripps Research Institute’s manu- script number

  4. An Oral DNA Vaccine Encoding Endoglin Eradicates Breast Tumors by Blocking Their Blood Supply

    DTIC Science & Technology

    2007-05-01

    Cancer Metastases 91 [24] R. Xiang, H.N. Lode, T.H. Chao , J.M. Ruehlmann, C.S. Dol- man, F. Rodriguez, J.L. Whitton, W.W. Overwijk, N.P. Res- tifo and R.A...031079 (to R.A.R) and DAMD 17-02-1-0562 (to R.X.) and EMD -Lexigen Research Center Billerica, MA grant SFP 1330 (to R.A.R). This is The Scripps

  5. A classical simulation of nonlinear Jaynes-Cummings and Rabi models in photonic lattices: comment.

    PubMed

    Lo, C F

    2014-01-27

    Recently Rodriguez-Lara et al. [Opt. Express 21(10), 12888 (2013)] proposed a classical simulation of the dynamics of the nonlinear Rabi model by propagating classical light fields in a set of two photonic lattices. However, the nonlinear Rabi model has already been rigorously proven to be undefined by Lo [Quantum Semiclass. Opt. 10, L57 (1998)]. Hence, the proposed classical simulation is actually not applicable to the nonlinear Rabi model and the simulation results are completely invalid.

  6. Towards Effective Emerging Infectious Diseases Surveillance: Evidence from Kenya, Peru, Thailand, and the U.S.-Mexico Border

    DTIC Science & Technology

    2012-09-01

    Vera,   Alicia ,  Anderson,  Christy  M,   Lozada,  Remedios,  Chait,  Lwbba,  Schooley,  Robert  T,  Zhang,  Xing-­‐quan...Valle,  Enrique  Navarro,  Rodriguez,  Alfonso,   Hernandez ,   Gerardo  Alvarez,  Rosales,  Cecilia,  Ortiz,  Javier

  7. West Europe Report No. 2139

    DTIC Science & Technology

    2007-11-02

    Gonzalez de Herrero. Youth, Students and Workers: Alicia Maria Garrido. Popular Struggle Coalition: Enrique Bueno. CDS: Federico Alonso Villalobos. West...de la Mora. PCOE-PCEU: Santiago Alberto Rodriguez. Segovia. PSOE: Isaias Herrero. AP-PDP-UL: Pedro Antonio Hernandez . PCE: Diego Penalosa. CDS...candidates list. Very close to him are Isidoro Hernandez Sito and Vicente Sanchez Cuadrado. Well-known UCD members have been rejected in Caceres

  8. The Effects of Composition Variation and Nitric Acid on the Stability and Reactivity of the Han-Based Liquid Propellants

    DTIC Science & Technology

    1991-01-01

    predicted by the simple model. Modification of propellant structure would be expected to alter a number of colligative and transport properties . The...content and a number of the physical properties of the propellant The effect of composition variation on performance was studied in order to gain... properties degrading to where they can no longer be used for their intended purpose (Feuer, Rodriguez, and Teets 1988). The result of contact with

  9. How Do the Metabolic Effects of Chronic Stress Influence Breast Cancer Biology?

    DTIC Science & Technology

    2012-04-01

    Balboa-Castillo T, Lopez-Garcia E, Leon-Munoz LM, Gutierrez-Fisac JL, Banegas JR, Rodriguez-Artalejo F 2009 BMI, Waist Circumference , and Mortality...epidemiological studies have revealed that social isolation is associated with an increased risk of both all-cause mortality and metabolic diseases such as...diabetes (1). Although association studies examining social isolation and human cancer risk have had mixed results (2)-4), the conclusions of these

  10. MM&T: Bibliography on Optical Testing with Appendix.

    DTIC Science & Technology

    1982-02-26

    I963-A ITI to TECHNICAL REPORT RH-CR-82-6’.-4 MM&T: BIBLIOGRAPHY ON OPTICAL TESTING WITH APPENDIX A. Comejo-Rodriguez Apdo..Postal 216 Puebla , Puebla ...15 Refs.). Descriptors: LENSES; OPTICAL TESTING; INTERFEROMETERS; LIGHT REFRACTION; VISION Identifiers: TALBOT INTERFEROMETERS; MOIRE FRINGES; LENS...here described. MARTIN, S. "INFLUENCE OF SURFACE DEFECTS ON THE GLARE CHARACTERISTICS OF A NIGHT VISION SYSTEM WITH REFRACTIVE OPTICS" Opt. Acta, 25

  11. The U.S. Army Reserve’s Private Public Partnership (P3) Program in Support of the Combatant Commander’s Security Cooperation Activities and the Readiness Opportunities for the U.S. Army Reserve

    DTIC Science & Technology

    2016-06-10

    support non-state actors makes them adversaries to the United States In Southeast Asia, the Islamic State of Iraq and the Levant threats (in Syria...Statement of General David M. Rodriguez, USA , Commander, United States Africa Command before the Senate Armed Services Committee, Senate Armed Services...Haram Islamic State-West Africa Province as parallel efforts in Central Africa in collaboration with the African Union Regional Task Force works to

  12. The STRONG STAR Multidisciplinary PTSD Research Consortium

    DTIC Science & Technology

    2009-09-01

    study funded by this award is to examine the effects of Cognitive-Behavioral Couples Therapy ( CBCT ; Monson, Rodriguez, & Warner, 2005) for posttraumatic...Samper, 2007; Jordan & Marmar, 1992; MacDonald, Chamberlain, Long, & Flett, 1999; Riggs, Byrne, Weathers, & Litz, 1998). CBCT includes...individual and couple level distress, we expect to see greater improvement in intimate relationship functioning with CBCT than with Prolonged Exposure (PE

  13. Human Factors in Intelligence, Surveillance, and Reconnaissance: Gaps for Soldiers and Technology Recommendations

    DTIC Science & Technology

    2014-07-01

    pp. 999– 1003, 2013. [8] C . D. Wickens, S . E. Gordon, and Y. Liu, An Introduction to Human Factors Engineering. New York: Longman, 1998. [9] D. A... S . L. Lingel, C ., Rhodes, A. Cordova, J. Hagen, J. Kvitky, and L. Menthe, “Methodology for improving the planning, execution, and assessment of...RDRL HRT G A RODRIGUEZ RDRL HRT I J HART RDRL HRT M C METEVIER RDRL HRT S B PETTIT 12423 RESEARCH PARKWAY ORLANDO FL 32826

  14. Aluminum Alloys Reinforced by Nano-Particles Dispersion

    DTIC Science & Technology

    2010-03-01

    Jose Martin Herrera Ramirez Collaborator M. Sc. Ivanovich Estrada Guel Collaborator Eng. Wilber Antiinez Flores Collaborator Students: 1. Raul...Lucero, I. Estrada-Guel, D.C. Mendoza-Ruiz, M. Jose " Yacaman, Mechanical and Microstructural Characterization of Aluminum Reinforced with Carbon...9. Santos Beltran, V. Gallegos Orozco, F. Alvarado Hernandez, S. Haro Rodriguez, A. Lopez Ibarra and R. Martinez Sanchez. Synthesis and

  15. Proceedings of the Discussion Meeting on Thermodynamics of Alloys Held in Barcelona, Spain on 23-26 May 1999. Series B. Volume 86

    DTIC Science & Technology

    1990-05-01

    G6mez G6mez. Departamento de F~Sica. Facultad de Ciencias. Universidad der Salamanca. Salamanca - 37008. EDITOR DE ELECTRICIDAD Y MAGNETISMO Prof. D...23 Ciudalcampo, 28700. S.S. Reyes (MADRID) Telef. 6.57.01.19 ELECTRICIDAD Y MAGNETISMO PRESIDENTE Pedro Cartujo Estebanez Depto. de Electronica...Ernesto Martin Rodriguez. Departamento de Electricidad . Facultad de Ciencias. Universidad de Murcia. Murcia - 30001. DIRECCION PARA ENVIAR LOS

  16. Development of a Suite of Luciferase Gene Probes for the Screening and Detection of Marine Bioluminescent Systems and Organisms

    DTIC Science & Technology

    2007-09-30

    phytoplankton cells, providing a novel tool for high resolution population genetic studies (Frommlet and Iglesias- Rodriguez, in review, J. Phycology ...polyedrum: a new approach to assess dinoflagellate population structure, J. Phycology . 5 Baker, A., Robbins, I., Moline, M.A. and Iglesias...4th European Phycological Congress, Oviedo, Spain, 22-27 July 2007. 6 Table 1: Stations sampled on the Ellett line during the D321b cruise to

  17. CONVERTING THE 'RIGHT TO LIFE' TO THE 'RIGHT TO PHYSICIAN-ASSISTED SUICIDE AND EUTHANASIA': AN ANALYSIS OF CARTER V CANADA (ATTORNEY GENERAL), SUPREME COURT OF CANADA.

    PubMed

    Chan, Benny; Somerville, Margaret

    2016-01-01

    In its landmark decision Carter v Canada (Attorney General), the Supreme Court of Canada ruled that the criminal prohibition on physician-assisted suicide and euthanasia for certain persons in certain circumstances violated their rights to life, liberty, and security of the person in sec. 7 of the Canadian Charter of Rights and Freedoms and thus was unconstitutional. The Supreme Court in effect overruled its earlier decision, Rodriguez v British Columbia (Attorney General), which upheld the prohibition as constitutionally valid, on the basis of changes in Charter jurisprudence and in the social facts since Rodriguez was decided. We argue that the Supreme Court's Carter decision shows conceptual disagreements with its Rodriguez decision concerning the nature and scope of the sec. 7-protected interests and the accompanying principles of fundamental justice. Not only do these conceptual differences have little to do with the changes that the Court in Carter invoked for 'revisiting' Rodriguez, the Court's articulation of the sec. 7 interests, particularly the right to life, and the principles of fundamental justice, especially the principle of over breadth, are problematic on their own terms. Furthermore, the way in which the Court dealt with evidence regarding abuses in permissive jurisdictions is also subject to criticism. We recommend that if, as now seems inevitable, legislation is introduced, it should mandate that assisted suicide and euthanasia be performed by specially licensed non-medical personnel and only on the authorization of a Superior Court judge. We also reject the key recommendations recently issued by the Provincial-Territorial Expert Advisory Group on Physician-Assisted Dying.

  18. Multiscale Modeling and Multifunctional Composites

    DTIC Science & Technology

    2013-07-17

    8) Here, Frs and Drs represent stress and the strain influence functions. The phase transformation fields, ,λ µ , appearing in Eqs...concentration factors Ar , Br , and influence functions Drs , Frs , , 1,=r s Q . Two applications are presented; one is a benchmark, classical...Journal for Multiscale Computational Engineering 8, 69-80. Berger, H., Kari S., Gabbert U., Rodriguez- Ramos , R., Guinovart, R., Otero, J.A., Bravo

  19. Formal Models of Composable Security Architectures

    DTIC Science & Technology

    2011-10-01

    other person or corporation; or convey any rights or permission to manufacture, use, or sell any patented invention that may relate to them...LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 12 19a. NAME OF RESPONSIBLE PERSON DILIA E. RODRIGUEZ a. REPORT U b. ABSTRACT U c. THIS...Lincoln, N. Mart́ı-Oliet, J. Meseguer, and C. Talcott . All About Maude — A High-Performance Logical Framework, How to Specify, Program and Verify

  20. Model Classes, Approximation, and Metrics for Dynamic Processing of Urban Terrain Data

    DTIC Science & Technology

    2013-01-01

    PDE’S, Analysis and Applications, (01 2011): 0. doi: 10.1142/S0219530511001728 05/13/2013 36.00 J. Manson , G. Petrova, S. Schaefer. Streaming...Graduate students supported DisciplinePERCENT_SUPPORTEDNAME Josiah Manson 0.11 computer science Peter Hall 0.05 mathematics Matthew Madison 0.04...Sood 0.03 computer science Billy Clack 0.05 computer science Casey Rodriguez 0.09 computer science Charles Arnold 0.05 mathematics Deepanshu Arora

  1. Monitoring Cetaceans in the North Pacific

    DTIC Science & Technology

    2009-04-01

    whale calls in the North Pacific Ocean: Seasonal and geographical variation 1996-2002. (by: Mary Ann Daher , Kathleen M. Stafford, Joseph E. George...correlates. (by: Kathleen M. Stafford, Sue E. Moore, Mary Ann Daher , Joseph E. George, David Rodriguez, and Kimberly Amaral) PEER-REVIEWED...remotely-sensed environmental variables to compare with current and future datasets. In 2007, a collaborative project with Ms. Mary Ann Daher of

  2. Marine Animal Sound Database. Twelve Years of Tracking 52-Hz Whale Calls from a Unique Source in the North Pacific

    DTIC Science & Technology

    2007-11-02

    THIS PAGE ABSTRACT OF William A. Watkins PAGESUnclass Unclass Unclass UL 19b. TELEPHONE NUMBER Ilnclude area code) (508) 289-3258 (Mary Ann Daher ...ABSTRACTS: In Press: Watkins, W.A., Daher , M.A. and George, J.E. 2004. Twelve years of tracking 52-Hz whale calls from a unique source in the North...Watkins, Mary Ann Daher *, Joseph E. George, David Rodriguez Woodv Hole Oceanographic Institution. MS 36, Woodv Hole, MA 02543, USA Received 2 March 2004

  3. Association of Ebola Virus Matrix Protein VP40 with Microtubules

    DTIC Science & Technology

    2005-04-01

    dynein has been reported for African swine fever virus protein 54 (1) as well as VP26 of herpes simplex virus (12), and binding to members of the plus...associated motor pro- teins for movement of viral particles to the site of budding has been proposed for African swine fever virus and vaccinia virus (22...Fernandez-Zapatero, L. Soto, C. Canto, I. Rodriguez-Crespo, L. Dixon, and J. M. Escribano. 2001. African swine fever virus protein p54 interacts with

  4. First Applications of the Joint Forces Command Information Operations Range - An ACETEF Perspective

    DTIC Science & Technology

    2006-12-01

    Integrated Battlespace Simulation and Test (IBST) Dept. Department of the Navy Commander ACETEF 54200A Bldg 2109 48150 Shaw Road Unit 5 Patuxent River...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) NAVAIR,Integrated Battlespace Simulation and Test (IBST) Dept.,48150 Shaw Road Unit 5,Patuxent River...event. Process and planning support was provided by Roberto Rodriguez and Marcia Flatau from the Booz Allen team. We are also grateful for the support

  5. How Does Ankle-foot Orthosis Stiffness Affect Gait in Patients With Lower Limb Salvage?

    DTIC Science & Technology

    2014-05-10

    Whitehead, Kelly Rodriguez, Dr Deanna Gates, and Dr Richard Neptune for their contributions to this project. References 1. Baker PA, Hewison SR. Gait...prospective controlled study. Gait Posture. 2006;24:142 151. 13. Faustini MC, Neptune RR, Crawford RH, Stanhope SJ. Manu facture of passive dynamic ankle...Clin Biomech. 1999;14:125 135. 27. Neptune RR, Kautz SA, Zajac FE. Contributions of the individual ankle plantar flexors to support, forward

  6. The WIND-HAARP-HIPAS Interferometer Experiment

    DTIC Science & Technology

    1999-04-22

    of HAARP and HIPAS are sufficient to modify the intervening plasma through heating and affect the fringe pattern. Repeating experiments of this kind...Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6750--99-8349 The WIND- HAARP -HIPAS Interferometer Experiment P. RODRIGUEZ AND M. J...1999 3. REPORT TYPE AND DATES COVERED Interim Report 4. TITLE AND SUBTITLE The WIND- HAARP -HIPAS Interferometer Experiment 5. FUNDING NUMBERS JO

  7. HAARP High Power Experiments and Observations of Ionospheric Interactions

    DTIC Science & Technology

    1996-01-01

    HAARP HIGH POWER EXPERIMENTS AND OBSERVATIONS OF IONOSPHERIC INTERACTIONS Paul Rodriguez(1), Edward Kennedy(2), Paul Kossey(3), Michael Kaiser(4...Initial experiments showed scintillation-like variations in low frequency propagation through the earth’s ionosphere . A HAARP -HIPAS transmission experiment... ionospheric irregularities. Recently, lunar echoes at 8 MHz were detected by WIND. The experiments at HAARP will extend to nonlinear regimes as power

  8. Latin America Report, No. 2717.

    DTIC Science & Technology

    2007-11-02

    Church, Pastora (Tomas Borge Martinez Interview; CARETAS, 22 May 83)... 103 Nunez Discusses Institutionalization Process ( Luis M. Arce; GRANMA, 10...Minister Tomas Borge Martinez by Jose Rodriguez Elizondo, in Borge’s office on Saturday 7 May] [Text] Some military commanders hang crosses around...Further Cuts NICARAGUA PERU Nora Astorga Interviewed on Country’s Foreign Policy (CARETAS, 6 Jun 83) 100 Borge on Political, Economic Situations

  9. China Report, Political, Sociological and Military Affairs, No. 445.

    DTIC Science & Technology

    2007-11-02

    Espriella of Panama and Luis Herrera Campins of Venezuela, sent a message today to presidents of all Central American states as well as President Reagan...August. Ecuadorian Foreign Minister Luis Valencia Rodriguez said in Quito on July 22 that the presence of U.S. warships in Central American waters has...President Luis Herrera Campins told reporters in Caracas on July 20 that the U.S. move was taken at "an inappropriate time." Venezuelan Foreign

  10. Country Reports on Terrorism 2006

    DTIC Science & Technology

    2007-04-01

    phase in the struggle began in March when ETA declared a “permanent cease-fire.” The government of President Jose Luis Rodriguez Zapatero agreed to...training, and financial assistance. Deputy Prime Minister Tonio Borg acknowledged this during his September visit to the United States. In February...the group exploded a massive car-bomb at Madrid’s Barajas International Airport, killing two individuals. The government of Spanish President Jose

  11. Anopheles (Anopheles) pseudopunctipennis Theobald (Diptera: Culicidae): Neotype Designation and Description

    DTIC Science & Technology

    2004-01-01

    1020 (M*, F*, L*); Aitken 1945: 327 (M, F*, P*, L, E*, taxonomy, biology); Vargas and Martinez Palacios 1956: 83 (M*, F*, P*, L*). Anopheles...complex of western America. Univ. Calif. Publ. Entomol. 7: 273Ð364. Alvarado , C. A., and R. L. Heredia. 1947. Observaciones sobre una nueva variedad...Cespedes, R. Vargas -Sagarnaga, and R. Rodriguez. 1992. Evidencia genética de un complejo de especie en Anopheles pseudopunctipennis pseudopunctipennis. Bol

  12. Modeling and Processing for Vector Sensors

    DTIC Science & Technology

    2006-09-30

    calculated particle velocity) and Michael Porter (ONR’s High Frequency Initiative) modified his Bellhop Gaussian beam model to calculate particle velocity...Martin Siderius, Christopher Harrison, Michael Porter , “A passive fathometer technique for imaging seabed layering using ambient noise”, J. Acoust. Soc...Eds. S. Jesus and O. Rodriguez, Carvoeiro, Portugal (2006). 2. Martin Siderius, Michael Porter , Paul Hursky, Vincent McDonald and the KauaiEx Group

  13. Hospital Corpsman University: From the Classroom to the Bedside

    DTIC Science & Technology

    2011-01-01

    CSS CSS CSS PED PED HAYNES 1300-1500 URO URO URO 18-22 ORT ORT ORT ORT CSS CSS SHABAZZ 1300-1500 LAB LAB LAB PT PT PT PT 18-22 PHA PHA HAYNES, C 1500...1700 DER DER DER URO URO URO URO 06-10 ORT ORT RODRIGUEZ 1500-1700 PHA PHA PHA DER DER DER DER 10-14 URO URO BURROUGHS 1500-1700 PT PT PT PHA PHA PHA

  14. Development and Fielding of High-Speed Laser Shadowgraphy for Electro-Magnetically Driven Cylindrical Implosions

    DTIC Science & Technology

    2013-06-01

    shockwave in a cylindrical geometry provides fundamental benchmarks used in the modeling of 1-D and 2-D hydrodynamic phenomena from high or solid...DEVELOPMENT AND FIELDING OF HIGH-SPEED LASER SHADOWGRAPHY FOR ELECTRO -MAGNETICALLY DRIVEN CYLINDRICAL IMPLOSIONS J. P. Roberts, G. Rodriguez...an electro -magnetically driven solid density liner implosion in Lucite is described. The laser shadowgraphy system utilizes an advanced high-energy

  15. LOVA Propellant Aging: Effect of Residual Solvent

    DTIC Science & Technology

    1994-07-01

    actual storage conditions) should be performed. 15 INTENTIONALLY LEFT BLANK. 16 5. REFERENCES Bergin, F. J. Applied Spectroscopy . vol. 43, no. 3...p. 511, 1989. Graf, R. T., J. L. Koenig, and H. Ishida. Applied Spectroscopy , vol. 39, p. 405, 1985. Grahm, J. A., W. M. Grimm III, and W. G...Harthcock (editors). Infrared Microspectroscopy. NY: Marcel Dekker, 1988. Pesce-Rodriguez, R. A., and R. A. Fifer. Applied Spectroscopy , vol. 45, no. 3

  16. ECC study in positron impact ionization in molecular hydrogen

    NASA Astrophysics Data System (ADS)

    Campeanu, R. I.; Zohouri Haghian, N.

    2012-12-01

    The electron capture to the continuum phenomenon in positron impact ionization of molecular hydrogen is studied with the distorted wave Born approximation. Our theoretical model produces results which are in better agreement with the experiment than the more elaborate models of [J. Fiol, V.D. Rodriguez, R.O. Barrachina, J. Phys. B: At. Mol. Opt. Phys. 34, 933 (2001)] and [A. Benedek, R.I. Campeanu, J. Phys. B: At. Mol. Opt. Phys. 40, 1589 (2007)] previously employed in this study.

  17. Latin America Report No. 2723

    DTIC Science & Technology

    2007-11-02

    Reyes Valero, technical chief of the Cuban contingent; Juan Manuel Hernandez Rodriguez, chief of the airport’s engineer- ing department; and Enrique...They had to abide by the contract." A Runway Over the Sea It is engineer Juan M. Hernandez who takes the floor to continue the explanation of how...of the mechanics and a little effort, we have been resolving the situation." Hernandez adds: "Furthermore, when the minister, Comrade Lopez Moreno

  18. The Office of the Materials Division

    NASA Technical Reports Server (NTRS)

    Ramsey, amanda J.

    2004-01-01

    I was assigned to the Materials Division, which consists of the following branches; the Advanced Metallics Branch/5120-RMM, Ceramics Branch/5130-RMC, Polymers Branch/5150-RMP, and the Durability and Protective Coatings Branch/5160-RMD. Mrs. Pamela Spinosi is my assigned mentor. She was assisted by Ms.Raysa Rodriguez/5100-RM and Mrs.Denise Prestien/5100-RM, who are both employed by InDyne, Inc. My primary assignment this past summer was working directly with Ms. Rodriguez, assisting her with setting up the Integrated Financial Management Program (IFMP) 5130-RMC/Branch procedures and logs. These duties consisted of creating various spreadsheets for each individual branch member, which were updated daily. It was not hard to familiarize myself with these duties since this is my second summer working with Ms Rodriguez at NASA Glenn Research Center. RMC ordering laboratory, supplies and equipment for the Basic Materials Laboratory (Building 106) using the IF'MP/Purchase Card (P-card), a NASA-wide software program. I entered into the IFMP/Travel and Requisitions System, new Travel Authorizations for the 5130-RMC Civil Servant Branch Members. I also entered and completed Travel Vouchers for the 5130-RMC Ceramics Branch. I assisted in the Division Office creating new Emergency Contact list for the Materials Division. I worked with Dr. Hugh Gray, the Division Chief, and Dr. Ajay Misra, the 5130-RMC Branch Chief, on priority action items, with a close deadline, for a large NASA Proposal. Another project was working closely with Ms. Rodriguez in organizing and preparing for Dr. Ajay K. Misra's SESCDP (two year detail). This consisted of organizing files, file folders, personal information, and recording all data material onto CD's and printing all presentations for display in binders. I attended numerous Branch meetings, and observed many changes in the Branch Management organization.

  19. Caffeine, Adenosine Receptors and Estrogen in Toxin Models of Parkinson’s Disease

    DTIC Science & Technology

    2009-10-01

    and among those with a his- tory of gout .11,12 Recently, we found that higher urate blood concentrations in pa- tients in the early stages of PD...hypertension, coronary heart disease, and stroke6,51-53 in addition to the known risks of gout and urolithiasis. Available data are therefore...838. 11. Alonso A, Rodriguez LA, Logroscino G, Hernan MA. Gout and risk of Parkinson disease: a prospective study. Neurology. 2007;69(17):1696-1700

  20. The Assistant for Specifying the Quality Software (ASQS) User’s Manual. Volume 2

    DTIC Science & Technology

    1990-09-01

    I I E T F N I R A AFACOR I R B V L C A I D BO0B B EII AlI T I A AlI PI I N TLI B T N N B B L E L L. So CY I I Y EA I I I R I I y T L S B L L T A T...Figure 8.12. .... ......... .......... .. .... A. SQS . ...... SYMSOIFTWARE UIREMENTS ANALYSIS DIETA I.ED DESIGN SeleFu PhaSe Softw L ie- PaseO...ET S FLA RT C GA I I E T F N I RA AFACTOR I R B V L CA I DB ORB8 EII AlI T I A AlI P I1 S tMWRE N TL 0 T N N B B L E L L IM 0C YI I Y EA I I I R I