Science.gov

Sample records for roland chin ting-chuen

  1. Chin augmentation.

    PubMed

    Choe, K S; Stucki-McCormick, S U

    2000-01-01

    The primary goal of facial aesthetic surgery is to restore, enhance, and rejuvenate the aging face to a more youthful appearance, achieving balance and harmony. The mental area must be addressed in order to have a complete synthesis of the face. The concept of augmenting the mental area with implants has evolved so significantly that it now stands by itself as an important procedure. Various autogenous implants for chin augmentation have been in use for over 100 years but have complications. The advent of synthetic materials has given rise to various types of alloplastic implants: Gore-Tex, Medpor, Supramid, Silastic, and Mersilene. No one implant is perfect for every face. This article overviews several alloplastic implants--their advantages, disadvantages, and complications, in addition to the different techniques of preparing and delivering the implants.

  2. Obituary: Roland Svensson, 1950-2003

    NASA Astrophysics Data System (ADS)

    Björnsson, Claes-Ingvar

    2003-12-01

    Roland Svensson was found dead on 8 April 2003. He succumbed to the complications arising from diabetes. His contribution to the understanding of the basic properties of relativistic plasmas remains a cornerstone when studying radiation processes in many astrophysical contexts. Roland was born on 6 May 1950 in Karlshamn, Sweden. At a young age he moved with his family to Skåne, the southernmost part of Sweden. This is where he received his early education including a BS in Physics at the University of Lund in 1973. For the rest of his life, this region was home for Roland. His mother and father are Linnea Martinsson (d. 1984) and Sune Svensson. The two younger brothers are Lennart and Peter. Lennart works as a machine engineer in Sweden while Peter has settled in California as a biology professor. Roland started graduate studies in theoretical physics in Lund before receiving a Fulbright Scholarship in 1976. He then moved to the University of California in Santa Cruz and enrolled in the astronomy and astrophysics graduate program. Although his interest in astronomy had been raised during the time in Lund, it was the stimulating environment in Santa Cruz that convinced Roland to concentrate on research in astronomy. With Roland's attitude of never accepting anything unless he understood its roots, his extended background in physics served him well throughout his astronomy career; in particular, it influenced his choice of a thesis topic. At the time, the importance of relativistic temperatures attained by accreting matter in the immediate vicinity of neutron stars and black holes was becoming clear. Roland set out to make a detailed description of the physical effects electron-positron pair production and annihilation would have on such plasmas. In 1981 Roland defended his thesis titled ``Physical Properties in Relativistic Plasmas" and completed his PhD under the supervision of Bill Mathews. Roland extended the results of his thesis during two post-docs, first at

  3. Chin force in violin playing.

    PubMed

    Obata, Satoshi; Kinoshita, Hiroshi

    2012-06-01

    Force generated between the left mandible of violinists and the chinrest of the violin was examined using a force-sensing chinrest developed in this study. A strain-gauge force sensor was built, and it was fixed between the violin's top plate and a chin cup. Fifteen professional/amateur violinists held the violin statically, played musical scales with different sound properties and sounding techniques, as well as an excerpt from a Max Bruch concerto. Peak and mean forces were evaluated for each task. In a separate experiment, lateral movement of the lower teeth due to different levels of voluntary chin force exertion was measured. Static holding forces observed were 15 and 22 N with and without the help of the left hand, respectively. Peak force increased from 16 N at soft dynamics to 20 N at strong dynamics during scales. The force further increased to 29 N with the use of vibrato technique and 35 N during shifts. Tempo and hand position did not affect the force. Playing a Bruch concerto induced a mean peak force of 52 N, ranging from 31 to 82 N among the violinists. The developed force-sensing chinrest could accurately record the generated chin force. Typical chin force to stabilize the violin during ordinary musical performance was less than 30 N, but it could momentarily exceed 50 N when technically demanding musical pieces were performed. The lateral shift of the mandible was fairly small (<0.4 mm) even with high chin-force exertion, possibly due to clenching of the molars.

  4. Chin force in violin playing.

    PubMed

    Obata, Satoshi; Kinoshita, Hiroshi

    2012-06-01

    Force generated between the left mandible of violinists and the chinrest of the violin was examined using a force-sensing chinrest developed in this study. A strain-gauge force sensor was built, and it was fixed between the violin's top plate and a chin cup. Fifteen professional/amateur violinists held the violin statically, played musical scales with different sound properties and sounding techniques, as well as an excerpt from a Max Bruch concerto. Peak and mean forces were evaluated for each task. In a separate experiment, lateral movement of the lower teeth due to different levels of voluntary chin force exertion was measured. Static holding forces observed were 15 and 22 N with and without the help of the left hand, respectively. Peak force increased from 16 N at soft dynamics to 20 N at strong dynamics during scales. The force further increased to 29 N with the use of vibrato technique and 35 N during shifts. Tempo and hand position did not affect the force. Playing a Bruch concerto induced a mean peak force of 52 N, ranging from 31 to 82 N among the violinists. The developed force-sensing chinrest could accurately record the generated chin force. Typical chin force to stabilize the violin during ordinary musical performance was less than 30 N, but it could momentarily exceed 50 N when technically demanding musical pieces were performed. The lateral shift of the mandible was fairly small (<0.4 mm) even with high chin-force exertion, possibly due to clenching of the molars. PMID:21952980

  5. Academic Performance in Children with Rolandic Epilepsy

    ERIC Educational Resources Information Center

    Piccinelli, P.; Borgatti, R.; Aldini, A.; Bindelli, D.; Ferri, M.; Perna, S.; Pitillo, G.; Termine, C.; Zambonin, F.; Balottin, U.

    2008-01-01

    The aim of this study was to investigate the frequency of reading, writing, and calculation disabilities in children with typical rolandic epilepsy (RE) and healthy control children. We also aimed to define the possible electroclinical markers of specific cognitive dysfunctions in RE. School abilities were evaluated and compared in 20 children…

  6. DETAIL OF PLAQUE DESCRIBING LION SCULPTURES BY ROLAND HINTON PERRY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF PLAQUE DESCRIBING LION SCULPTURES BY ROLAND HINTON PERRY, NORTHWEST ABUTMENT - Connecticut Avenue Bridge, Spans Rock Creek & Potomac Parkway at Connecticut Avenue, Washington, District of Columbia, DC

  7. 21 CFR 878.3550 - Chin prosthesis.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Chin prosthesis. 878.3550 Section 878.3550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3550 Chin prosthesis....

  8. 21 CFR 878.3550 - Chin prosthesis.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Chin prosthesis. 878.3550 Section 878.3550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3550 Chin prosthesis....

  9. 21 CFR 878.3550 - Chin prosthesis.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Chin prosthesis. 878.3550 Section 878.3550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3550 Chin prosthesis....

  10. 21 CFR 878.3550 - Chin prosthesis.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Chin prosthesis. 878.3550 Section 878.3550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3550 Chin prosthesis....

  11. 21 CFR 878.3550 - Chin prosthesis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Chin prosthesis. 878.3550 Section 878.3550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3550 Chin prosthesis....

  12. Roland Svensson (1950--2003), in Memoriam

    NASA Astrophysics Data System (ADS)

    Björnsson, C.-I.; Ryde, F.; Larsson, S.; Borgonovo, L.; de Val Borro, M.; Mészáros, A.

    Professor Roland Svensson's contribution to the understanding of the basic properties of relativistic plasmas remains a cornerstone in the study of radiation processes in many astrophysical contexts, for instance, gamma-ray bursts. He passed away on April 8, 2003, at an age of 52, in his home in Saltsjöbaden, Sweden. He served on the Scientific Advisory Committee (SAC) for the Minisymposium ``Physics of Gamma-Ray Bursts" which was a part of the Joint European and National Astronomical Meeting for 2003 (JENAM 2003) held in Budapest, Hungary. These proceedings are dedicated to his memory.

  13. Numerical survey of the different shapes of human chin.

    PubMed

    Tamir, Abraham

    2013-09-01

    Experimental results are reported for the numerical quantities of the different shapes of human chin where, to the best of the author's knowledge, this approach has never been applied. The results are based on 3143 pictures of chins taken from the Internet of which 1328 were of women and 1815 of men. The author has succeeded to classify all the chins into 3 shapes: the cleft chin for men only, 2.23% of the total; the double chin, 15.69% = 14.0% + 1.69%; and the normal chin, 82.09% = 41.52% + 40.57%, where the first number is for men and the second for women.

  14. Academic performance in children with rolandic epilepsy.

    PubMed

    Piccinelli, P; Borgatti, R; Aldini, A; Bindelli, D; Ferri, M; Perna, S; Pitillo, G; Termine, C; Zambonin, F; Balottin, U

    2008-05-01

    The aim of this study was to investigate the frequency of reading, writing, and calculation disabilities in children with typical rolandic epilepsy (RE) and healthy control children. We also aimed to define the possible electroclinical markers of specific cognitive dysfunctions in RE. School abilities were evaluated and compared in 20 children (eight males, 12 females; mean age 10y 3mo [SD 1y 7mo]; range 7y 9mo-12y 9mo) consecutively diagnosed with typical RE, and a group of 21 healthy controls (nine males, 12 females; mean age 10y 4mo [SD 1y 8mo]; range 7y 6mo-13y 3mo). All the children received standardized neuropsychological tests. For each patient an exhaustive seizure diary was kept and all the sleep electroencephalogram (EEG) recordings were reviewed. Specific difficulties with reading, writing, and calculation (diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition) were found in nine out of 20 children with RE and two out of 21 healthy controls (chi2=0.01). The specific learning disabilities in the RE group were correlated with a marked increase in epileptiform discharges during sleep (chi2=0.02) and an early onset of epilepsy (chi2=0.02). Our findings suggest that seizure onset before age 8 years and epileptiform discharges (more than 50% of the sleep EEG recording) in several tracings over more than a year are relevant markers for identifying patients at risk of developing academic difficulties. PMID:18294216

  15. Chin surgery: I. Augmentation--the allures and the alerts.

    PubMed

    Zide, B M; Pfeifer, T M; Longaker, M T

    1999-11-01

    The correction of sagittal deformities of the chin presents a seemingly simple surgical challenge. However, several authors have reported negative sequelae from such chin surgery, During the past 11 years, the senior author (B.M.Z.) has evaluated more than 100 such cases of adverse results after chin augmentation. Many surgeons, it seems, use chin implants unnecessarily and, thus, get into trouble. Because alloplastic chin augmentation is deceptively easy, it tends to be overused in certain situations. Either the surgeon's evaluation is too narrowly focused or his/her abilities to perform other types of surgery (e.g., osseous genioplasty) are limited. Herein, the authors present a diagnostic evaluation protocol, QUAC (Quick Analysis of the Chin), to assist in avoiding simple mistakes in alloplastic chin augmentation. This protocol will alert the surgeon to situations that, if unrecognized, will cause problems and create an unhappy patient. This article will specifically focus on (1) lower lip analysis; (2) the effect of the labiomental fold; (3) chin pad evaluation, both static and dynamic; (4) the anatomy of the cleft chin; (5) special situations; and (6) how to troubleshoot three common problems. The accompanying article, Chin Surgery II, will present a new operation that treats a chin problem that was previously difficult to correct.

  16. Superculture? Thoughts Prompted by Roland S. Persson's Essay

    ERIC Educational Resources Information Center

    Tebbs, Trevor J.

    2012-01-01

    The author finds Roland S. Persson's (2012a) paper to be timely, fascinating, important and powerful. At risk of mixing metaphors, it provides much food for thought and a penetrating lens through which all those vested in the optimal realisation of human potential would be prudent to review their own perceptions, boundaries of belief and…

  17. A Flipped Spoon and Chin Prompt to Increase Mouth Clean

    ERIC Educational Resources Information Center

    Dempsey, Jack; Piazza, Cathleen C.; Groff, Rebecca A.; Kozisek, Jennifer M.

    2011-01-01

    We treated the liquid refusal of a 15-month-old girl using 2 antecedent manipulations: flipped spoon and chin prompt. Use of the chin prompt in the absence of the flipped spoon failed to produce increases in mouth clean (a product measure of swallowing). By contrast, modest increases in mouth clean resulted from the implementation of the flipped…

  18. [An infected necrosis of the chin].

    PubMed

    Muller, B S; van Goor, H F; Rosenberg, A J W P

    2016-01-01

    A 51-year-old man was referred by his dentist to a maxillofacial surgeon with complaints of illness and pain in the mandible, associated with a rapidly expanding area of black gingiva and mucosa surrounding the lower front teeth. Clinically and radiographically there was evidence of an infected necrosis of the chin and floor of mouth. Following debridement at the operating room, the patient was treated at the intensive care unit for septic shock leading to prolonged hospitalisation. Investigation of the bone marrow did not provide an explanation for pancytopenia or the severity of the illness. In addition, genetic investigation of thiopurine S-methyltransferase gene showed no mutations. This gene codes for an identically named protein enzyme that contributes in the metabolising of the medicine azathioprine, used daily for an autoimmune disease. A combination of the use of azathioprine, a folic acid deficiency and sepsis led to this exceptional course of illness. Therapeutic intervention consisted of surgical debridement and treatment of the bacteraemia. Afterwards several corrective surgeries were necessary to restore oral functions.

  19. Phylogeography and taxonomy of White-chinned and Spectacled Petrels.

    PubMed

    Mareile Techow, N M S; Ryan, Peter G; O'Ryan, Colleen

    2009-07-01

    The genus Procellaria traditionally consists of four species, two restricted to New Zealand and two widespread in the Southern Ocean. All four are threatened because of incidental mortality on longlines and other fishing gear. The White-chinned Petrel P. aequinoctialis is the seabird killed in largest numbers by fisheries in the Southern Ocean. A spectacled form recently has been elevated to species status, Spectacled Petrel P. conspicillata, based on differences in morphometrics, vocalisations and breeding phenology. Cytochrome b sequences support species status for the Spectacled Petrel and show that the White-chinned Petrel has two regional populations, one around New Zealand and one throughout the South Atlantic and Indian Oceans. White-chinned and Spectacled Petrels segregated approximately 0.90 million years ago by allopatric fragmentation, and the two populations within White-chinned Petrels diverged approximately 0.35 million years ago. Climate changes and corresponding changes in ocean currents are most likely responsible for these patterns. PMID:19364537

  20. A flipped spoon and chin prompt to increase mouth clean.

    PubMed

    Dempsey, Jack; Piazza, Cathleen C; Groff, Rebecca A; Kozisek, Jennifer M

    2011-01-01

    We treated the liquid refusal of a 15-month-old girl using 2 antecedent manipulations: flipped spoon and chin prompt. Use of the chin prompt in the absence of the flipped spoon failed to produce increases in mouth clean (a product measure of swallowing). By contrast, modest increases in mouth clean resulted from the implementation of the flipped spoon alone. The greatest increases in mouth clean resulted from the combination of the 2 manipulations. PMID:22219548

  1. The trouble with CHINS (community health information networks).

    PubMed

    Appleby, C

    1995-05-01

    If one had to choose a single acronym that captures both the vision and folly of today's health care industry, it would be "CHIN." The term--which stands for "community health information network"--combines the idealism of community-based health care with the promise of computer automation. Ironically, the acronym may come to be synonymous with "sticking your neck out"; these costly computer networks presuppose a quixotic collaboration among hospitals and health systems long at one another's competitive throats. For CHINs to succeed, they must overcome barriers that many industry insiders say are insurmountable.

  2. Ak-Chin Indian Community Biomass Feasiiblity Study

    SciTech Connect

    Mark A. Moser, RCM Digesters, Inc.; Mark Randall, Daystar Consulting, LLC; Leonard S. Gold, Ak-Chin Energy Services & Utility Strategies Consulting Group

    2005-12-31

    Study of the conversion of chicken litter to biogas for the production of energy. There was an additional requirement that after extracting the energy from the chicken litter the nutrient value of the raw chicken litter had to be returned to the Ak-Chin Farms for use as fertilizer in a form and delivery method acceptable to the Farm.

  3. Characteristics of Dry Chin-Tuck Swallowing Vibrations and Sounds

    PubMed Central

    Dudik, Joshua M; Jestrović, Iva; Luan, Bo; Coyle, James L.; Sejdić, Ervin

    2015-01-01

    Objective The effects of the chin-tuck maneuver, a technique commonly employed to compensate for dysphagia, on cervical auscultation are not fully understood. Characterizing a technique that is known to affect swallowing function is an important step on the way to developing a new instrumentation-based swallowing screening tool. Methods In this study, we recorded data from 55 adult participants who each completed five saliva swallows in a chin-tuck position. The resulting data was processed using previously designed filtering and segmentation algorithms. We then calculated 9 time, frequency, and time-frequency domain features for each independent signal. Results We found that multiple frequency and time domain features varied significantly between male and female subjects as well as between swallowing sounds and vibrations. However, our analysis showed that participant age did not play a significant role on the values of the extracted features. Finally, we found that various frequency features corresponding to swallowing vibrations did demonstrate statistically significant variation between the neutral and chin-tuck positions but sounds showed no changes between these two positions. Conclusion The chin-tuck maneuver affects many facets of swallowing vibrations and sounds and its effects can be monitored via cervical auscultation. Significance These results suggest that a subject’s swallowing technique does need to be accounted for when monitoring their performance with cervical auscultation based instrumentation. PMID:25974926

  4. Mechanisms of Airway Protection during Chin-Down Swallowing

    ERIC Educational Resources Information Center

    Macrae, Phoebe; Anderson, Cheryl; Humbert, Ianessa

    2014-01-01

    Purpose: This study examined the effects of chin-down swallowing on laryngeal vestibule closure. It also investigated the technique's rehabilitative impact, by assessing the stability of effects across multiple trials and aftereffects in neutral swallows on cessation of the technique. Method: Duration of laryngeal vestibule closure (dLVC) was…

  5. Numb chin syndrome secondary to leptomeningeal carcinomatosis from gastric adenocarcinoma.

    PubMed

    Riesgo, Vincent J; Delgado, Silvia R; Poveda, Julio; Rammohan, Kottil

    2015-04-01

    Numb chin syndrome (NCS) can be a sign of malignancy. Its association with gastric adenocarcinoma is rare. We report a case of a 27-year-old Hispanic female that presented with complaint of left sided headache associated with numbness of the left side of chin and lower gingiva. Initial brain MRI, whole body gallium scan, high resolution CT of chest and elevated protein in the CSF were suggestive of sarcoidosis. She was treated with IV steroids with transient clinical improvement. Two weeks later, her symptoms worsened and further evaluation revealed the diagnosis of a poorly differentiated metastatic gastric adenocarcinoma with leptomeningeal involvement. This case report aims to emphasize the importance of identifying NCS as a possible indication of an underlying malignant condition. Reported cases of NCS associated with metastatic gastric adenocarcinoma are very rare.

  6. Surgical placement of a chin cleft concomitant with genioplasty.

    PubMed

    Sher, M R

    1980-01-01

    This article presents a surgical technique for creation of a chin cleft in conjuction with advancement genioplasty. The technique is simple. However, the cleft should be made deeper than seems aesthetically desirable at the time of surgery because healing and muscle function will decrease the final depth of the depression. The depth that can be anticipated can be determined by the degree of tension of the subcutaneous sutures. Minor recontouring of bone may be necessary when there is a prominent bony apex to the symphysis. The actual chin cleft is a soft tissue phenomenon, rather than a bone cleavage point. It is not suggested that this procedure be offered to every patient, but familiarity with the technique is needed should there be a request to perform such surgery.

  7. [Acute anterior bi-opercular syndrome of critical origin in epilepsy with rolandic spikes].

    PubMed

    Septien, L; Gras, P; Giroud, M; Dumas, R

    1992-01-01

    We report the fifth case of a palsy of the lips, the tongue and the pharynx corresponding to an acute pseudo-bulbar syndrome causing speech arrest, and hyper-sialorrhea. The clinical examination and the electroencephalograms showed a partial motor status with spikes discharges in the two central regions, in a 10-year old boy known to have epilepsy with rolandic spikes. The status epilepticus ceased with phenytoin therapy. Although epilepsy with rolandic spikes is a benign one without any cerebral lesion, a partial motor status epilepticus is possible and does not change prognosis. PMID:1303564

  8. Policy, Practice in Giftedness, and Research Methodologies: Response to Roland S. Persson's Article

    ERIC Educational Resources Information Center

    Matthews, Dona J.

    2012-01-01

    The author finds the target article "Cultural Variation and Dominance in a Globalised Knowledge Economy" to be a thoughtful exploration of an important topic for all social scientists, certainly including those who study gifted development and education. Roland S. Persson (2012a) raises many questions about policy and practice in giftedness…

  9. "Profound Levels of Learning" through Brain-Based Teaching: A Tribute to Roland Barth

    ERIC Educational Resources Information Center

    Shore, Rebecca Ann

    2012-01-01

    This article is a tribute to the writings of Dr. Roland Barth through a personal story spanning over two decades. It explores Dr. Barth's personal vision of an effective school through recent brain-based principles. It revisits Barth's axioms and uses recent implications from the neurosciences as new supporting evidence for their success in…

  10. [Chin Junso--founder of the medical lineage Uirou].

    PubMed

    Sugiyama, Shigeru

    2002-01-01

    Chin Junso was an excellent doctor with expertise in the medical sciences gained from teachings that originated in the Kin and Gen dynasties. He devised and used unique prescriptions with various aromatics, which he collectively called Hoyaku (fragrant medication). Although he did not desire to enter government service because of his old age, his knowledge and wishes were handed down to his descendants. He led a quiet life in his later years by practicing meditation at a Zen temple of the Rinzai-shu order. Uirou in Odawara incidentally belongs to the Nichiren-shu order and not to the lineage of Junso. Nichiren-shu was a Buddhism order popular among townspeople in Kyoto at that time. It may be of interest to note the second master Souju and the third master Jouyu contributed to the trade between Japan and Korea.

  11. Voice and Valence-Altering Operations in Falam Chin: A Role and Reference Grammar Approach

    ERIC Educational Resources Information Center

    King, Deborah

    2010-01-01

    This dissertation describes and analyzes voice and valence-altering operations in Falam Chin, a Tibeto-Burman language of Burma. The data is explained within the framework of Role and Reference Grammar (RRG), which supplies several key concepts particularly useful for generalizing the behavior of the Falam Chin operations. The first is RRG's…

  12. Choosing the Best Procedure to Augment the Chin: Is Anything Better than an Implant?

    PubMed

    Sykes, Jonathan M; Fitzgerald, Rebecca

    2016-10-01

    The chin plays a very important role in overall facial appearance, and aesthetic procedures to augment the chin in patients with microgenia can improve overall facial balance. Many procedures exist to enhance the appearance of a small chin. Procedures include surgeries such as placement of an alloplast implant and bony osteotomy of the mentum (sliding genioplasty). The advantages and disadvantages of each surgical technique are well documented. Although surgical augmentation of the chin has been the gold standard of therapy, recent development of injectable filler products with lifting capacity has changed the way that many practitioners alter chin shape and size. Filler agents allow augmentation of the chin in horizontal (projection), vertical, and transverse dimensions. Injectable fillers are a simple, noninvasive procedure that causes minimal to no downtime, incurs minimal risks, and allows the practitioner to shape the chin in three dimensions. This procedure allows patients to enhance their chin size without requiring an operative visit. As more and varied filler products become FDA-approved, the versatility and application of these agents will increase. PMID:27680522

  13. Cognitive deficits in children with benign rolandic epilepsy of childhood or rolandic discharges: a study of children between 4 and 7 years of age with and without seizures compared with healthy controls.

    PubMed

    Danielsson, Julia; Petermann, Franz

    2009-12-01

    Recent developments in research on cognitive abilities in benign rolandic epilepsy of childhood with centrotemporal spikes have led to interest in the following domains: language, memory, executive, motor, and visual-constructive functions. As previous studies have investigated the cognitive development of mainly school-aged children, this study focuses on preschool and elementary school children. Twenty-five children affected by benign rolandic epilepsy/rolandic discharges and 25 healthy children matched for age and sex were enrolled in this retrospective study. The mean IQ scores were 94.76 for children with epilepsy and 99.3 for control children. For the children with benign rolandic epilepsy, cognitive testing revealed increased verbal and nonverbal deficits with respect to articulation (P=0.002), auditory memory (P=0.003), visual memory (P=0.016), language comprehension (P=0.009), and visual-constructive performance (P=0.033), as compared with the children in the control group. In our sample, the results showed an association between rolandic epilepsy and language and memory deficits. As cognitive development in preschool children is progressive and dynamic, larger prospective follow-up studies, with assessments at different time points, will facilitate understanding of the cognitive profiles of children with rolandic epilepsy.

  14. Roland Kuhn—100th Birthday of an Innovator of Clinical Psychopharmacology

    PubMed Central

    Steinberg, Holger; Himmerich, Hubertus

    2012-01-01

    On the occasion of his 100th birthday this letter is to pay tribute to Swiss psychiatrist and psychopharmacologist Roland Kuhn (1912–2005), who established the antidepressant effects of imipramine starting in 1956. Since until now only monoaminergic-based antidepressants such as this substance found their way into psychopharmacological therapy, one can say that Kuhn established the lead antidepressant substance and has hence fundamentally changed clinical psychiatry and care for the mentally ill.

  15. Combined treatment with botulinum toxin and hyaluronic acid to correct unsightly lateral-chin depression*

    PubMed Central

    Braz, André Vieira; Louvain, Dailana; Mukamal, Luana Vieira

    2013-01-01

    With aging, anatomical changes are observed in the face. In the lower third, these changes are expressed as ptosis of the angle of the mouth, lip enhancement groove mentalis; decrease in concavity between the jaw and neck and very noticeable platysmal banding. The repeated contraction of muscles of the lateral-chin together with the band platysmal side form what are called a marionette groove. Treating the whole lateral-chin area can result in a more harmonious aspect of the face when compared with treatment of a marionette groove in isolation. In this paper we describe combined treatment of the lateral chin area using botulinum toxin and fillers. PMID:23539022

  16. Static test of a fan-powered chin nozzle for V/STOl applications

    NASA Technical Reports Server (NTRS)

    Salemann, V.

    1981-01-01

    The performance of a "chin" nozzle which diverts flow in a downward direction immediately downstream of a fan typical of designs suitable for V/STOL A applications was evaluated. Back pressure distortion to the fan and fan discharge pressure distortion were also measured. Results show that the distortion is significant at the closest spacing between the fan exit and cascade entrance tested, and that the chin nozzle performance deteriorates with increased flow diversion to the chin nozzle. Color oil flow visualization on video tape and still photos were also obtained. Tests were conducted behind a 12" model fan in the NASA-Lewis fan calibration facility.

  17. Paraffin Granulomata, “Witch's Chin,” and Nasal Deformities

    PubMed Central

    Field, Lawrence Marshall

    2010-01-01

    A 57-year-old Filipino woman had paraffin materials placed in her nose, chin, and cheeks approximately 15 years prior to consultation. Progressive enlargement of the chin had occurred, simulating a witch's chin deformity, with a lesser degree of the distal nose and columellar area. Restoration of a relatively normal chin contour was accomplished by using tumescent bi-level anesthesia, mobilizing the protuberant tissues, hemi-ressecting the excess skin, and sculpting the subjacent tissue to an appropriate degree. The nose was then entered at the columellar junction with the upper lip, an open rhinotomy was accomplished, the supra-cartilaginous fibrous tissue was serially ressected to reform the profile, the cartilage was replaced to narrow the nasal configuration, and the nose structure was then replaced. Cosmetic improvement was significant. PMID:20725553

  18. Early secondary bone grafting of alveolar cleft defects. A comparison between chin and rib grafts.

    PubMed

    Borstlap, W A; Heidbuchel, K L; Freihofer, H P; Kuijpers-Jagtman, A M

    1990-07-01

    Since 1981 in cleft lip and palate patients a combined surgical-orthodontic procedure has been performed to eliminate the residual alveolar cleft. For early secondary bone grafting (before the eruption of the canine tooth) initially the graft tissue of choice was rib. Since 1984 chin bone has also been used. Sixty one patients with complete unilateral clefts were reviewed (mean age 9.5 years). 15.7% of the rib graft cases showed resorption of the graft of 50% and more. Such resorption was not found in any of the chin graft cases. No complications such as wound dehiscence, sequestration, excessive resorption of bone or recurrence of an oro-nasal fistula were found in the chin graft group. This leads to the conclusion that if enough bone is available in the chin region to bridge the defect, this graft is preferable to a rib graft.

  19. "Dimple"-matically correct - Revisiting the technique for the creation of a chin dimple.

    PubMed

    Mokal, N J; Desai, M F

    2012-01-01

    The boom in cosmetic surgery has ushered in the age of the "designer dimple." In the current scenario where an increasing number of Indians are seeking cosmetic surgery, we present our technique for creation of chin dimples. We used this simple and straightforward technique in one patient. The principal steps of the technique include thinning the skin flap, creating a concave indentation in the mandibular symphysis, and obtaining an adhesion between the thinned skin flap and the indented bone. An aesthetically pleasing chin dimple was achieved. We propose that the bony contouring improves the chances of creating a permanent chin cleft or dimple. Our technique for creation of chin dimples aims to give an aesthetic and permanent result by altering the underlying contour of mandibular symphysis and achieving accurate skin coaptation with non-absorbable sutures.

  20. Short faces, big tongues: developmental origin of the human chin.

    PubMed

    Coquerelle, Michael; Prados-Frutos, Juan Carlos; Rojo, Rosa; Mitteroecker, Philipp; Bastir, Markus

    2013-01-01

    During the course of human evolution, the retraction of the face underneath the braincase, and closer to the cervical column, has reduced the horizontal dimension of the vocal tract. By contrast, the relative size of the tongue has not been reduced, implying a rearrangement of the space at the back of the vocal tract to allow breathing and swallowing. This may have left a morphological signature such as a chin (mental prominence) that can potentially be interpreted in Homo. Long considered an autopomorphic trait of Homo sapiens, various extinct hominins show different forms of mental prominence. These features may be the evolutionary by-product of equivalent developmental constraints correlated with an enlarged tongue. In order to investigate developmental mechanisms related to this hypothesis, we compare modern 34 human infants against 8 chimpanzee fetuses, whom development of the mandibular symphysis passes through similar stages. The study sets out to test that the shared ontogenetic shape changes of the symphysis observed in both species are driven by the same factor--space restriction at the back of the vocal tract and the associated arrangement of the tongue and hyoid bone. We apply geometric morphometric methods to extensive three-dimensional anatomical landmarks and semilandmarks configuration, capturing the geometry of the cervico-craniofacial complex including the hyoid bone, tongue muscle and the mandible. We demonstrate that in both species, the forward displacement of the mental region derives from the arrangement of the tongue and hyoid bone, in order to cope with the relative horizontal narrowing of the oral cavity. Because humans and chimpanzees share this pattern of developmental integration, the different forms of mental prominence seen in some extinct hominids likely originate from equivalent ontogenetic constraints. Variations in this process could account for similar morphologies.

  1. Short faces, big tongues: developmental origin of the human chin.

    PubMed

    Coquerelle, Michael; Prados-Frutos, Juan Carlos; Rojo, Rosa; Mitteroecker, Philipp; Bastir, Markus

    2013-01-01

    During the course of human evolution, the retraction of the face underneath the braincase, and closer to the cervical column, has reduced the horizontal dimension of the vocal tract. By contrast, the relative size of the tongue has not been reduced, implying a rearrangement of the space at the back of the vocal tract to allow breathing and swallowing. This may have left a morphological signature such as a chin (mental prominence) that can potentially be interpreted in Homo. Long considered an autopomorphic trait of Homo sapiens, various extinct hominins show different forms of mental prominence. These features may be the evolutionary by-product of equivalent developmental constraints correlated with an enlarged tongue. In order to investigate developmental mechanisms related to this hypothesis, we compare modern 34 human infants against 8 chimpanzee fetuses, whom development of the mandibular symphysis passes through similar stages. The study sets out to test that the shared ontogenetic shape changes of the symphysis observed in both species are driven by the same factor--space restriction at the back of the vocal tract and the associated arrangement of the tongue and hyoid bone. We apply geometric morphometric methods to extensive three-dimensional anatomical landmarks and semilandmarks configuration, capturing the geometry of the cervico-craniofacial complex including the hyoid bone, tongue muscle and the mandible. We demonstrate that in both species, the forward displacement of the mental region derives from the arrangement of the tongue and hyoid bone, in order to cope with the relative horizontal narrowing of the oral cavity. Because humans and chimpanzees share this pattern of developmental integration, the different forms of mental prominence seen in some extinct hominids likely originate from equivalent ontogenetic constraints. Variations in this process could account for similar morphologies. PMID:24260566

  2. The Sequence of Swallowing Events During the Chin-Down Posture

    PubMed Central

    Young, Jennifer L.; Macrae, Phoebe; Anderson, Cheryl; Taylor-Kamara, Isha

    2015-01-01

    Purpose This study investigated the effect of the chin-down posture on the sequence of swallowing events in healthy adults. Method Sixteen healthy participants performed 45 5-ml thin liquid swallows during videofluoroscopy: 5 neutral head position, 30 chin-down posture, and then 10 neutral head position. Eight swallowing events were measured: the time of hyoid burst, bolus head in the pharynx, bolus tail in the pharynx, laryngeal vestibule closure (LVC), upper esophageal sphincter (UES) opening, bolus head in the UES, bolus tail exiting the pharynx, and laryngeal vestibule opening (LVO). Results Our key finding is that LVC was one of the first 3 swallowing events in 69% of neutral swallows and in 78% of chin-down swallows (p = .006). Also, LVO occurred last in 14% of chin-down swallows but never occurred last in the preceding neutral swallows (p ≤ .001). Thus, in chin-down swallows, LVC occurred earlier and LVO occurred later. Conclusions The chin-down posture may be beneficial for individuals with delayed onset of LVC and reduced duration of the LVC. Future studies are needed to examine this effect in individuals with dysphagia. PMID:26225454

  3. A festschrift for Roland L. Weinsier: nutrition scientist, educator, and clinician.

    PubMed

    Heimburger, Douglas C; Allison, David B; Goran, Michael I; Heini, Adrian F; Hensrud, Donald D; Hunter, Gary R; Klein, Samuel; Kumanyika, Shiriki K; Kushner, Robert F; Rolls, Barbara J; Schoeller, Dale; Schutz, Yves

    2003-10-01

    Roland L. Weinsier, M.D., Dr.P.H., devoted himself to the fields of nutrition and obesity for more than 35 years. He contributed outstanding work related to the treatment of obesity through dietary and lifestyle change; metabolic/energetic influences on obesity, weight loss, and weight regain; body composition changes accompanying weight loss and regain; the health benefits and risks of weight loss; nutrition education for physicians; and nutrition support of sick patients. He served on the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Task Force on Prevention and Treatment of Obesity, as Chair of the University of Alabama at Birmingham's Department of Nutrition Sciences, and as Founder and Director of its NIDDK-funded Clinical Nutrition Research Center. He was a long-time and active member of NAASO, serving in the roles of Councilor, Publications Committee Chair, Continuing Medical Education Course Director, Public Relations Committee Chair, and Membership Committee Co-Chair, to name just a few. He was well respected as a staunch defender of NAASO's scientific integrity in these roles. Sadly, Roland Weinsier died on November 27, 2002. He will be missed and remembered by many as a revered and beloved teacher, mentor, healer, and scholar.

  4. Tongue contractions during speech may have led to the development of the bony geometry of the chin following the evolution of human language: a mechanobiological hypothesis for the development of the human chin.

    PubMed

    Ichim, Ionut; Kieser, Jules; Swain, Michael

    2007-01-01

    One of the most fundamental yet unanswered questions of human evolution is that of the development of the chin. Whereas it is known that the chin, or mentum osseum, is an unique anatomical feature of modern humans that emerged during the Middle and Late Pleistocene, its origin and biomechanical significance are the subjects of intense controversy. Theories range from the suggestion that the chin evolved as a result of progressive reduction of the dental arch, which left it as a protrusion, to the hypothesis that it provided resistance to mandibular bending during mastication. Until now however, no accepted functional explanation of the human chin has emerged. Here, we develop the hypothesis that the actions of the tongue and non-masticatory orofacial muscles may have played a significant role on the development of the human chin. We report numerical simulations of the forces and resultant stresses developed in hypothetical chinned and non-chinned mandibles. Using empirical data and estimates of the forces generated by the human tongue during speech, our hypothesis suggests that the chin might in fact have developed as a result of the actions of the tongue and perioral muscles, rather than as a buttress to withstand masticatory induced stress. This provides a new perspective on the generation of the chin and importantly, suggests that its appearance may be causally related to the development of the human language.

  5. Biomechanical response of the human mandible to impacts of the chin.

    PubMed

    Craig, Matthew; Bir, Cynthia; Viano, David; Tashman, Scott

    2008-10-20

    The purpose of this study was to determine the force-time and force-displacement response of the human mandible under direct loading at the chin. Sub-fracture response of the mandible and temporomandibular joint (TMJ) were analyzed from 10 cadavers that were impacted at the chin with a 2.8-kg mass at drop heights of 300, 400 and 500 mm and a 5.2-kg mass at 500 mm. Motion of radio-opaque markers adhered to the surface of the bone was recorded at 1000 Hz by a bi-planar X-ray and converted to three-dimensional coordinates. Peak force ranged from 0.90 to 4.54 kN causing chin displacement of 1.2-4.4 mm. A bi-linear response was observed with stiffness of 475.1+/-199.8 kN/m for chin displacement resulting from loading up to 0.6 kN and 2381.6+/-495.7 kN/m for loads from 0.6 to 3.25 kN. This defines the biomechanical response of the mandible for chin motion under impact loading. The response of different segments of the mandible and TMJ are also documented. Force-time and force-displacement response corridors for the mandible can be used for finite element model and/or the development and validation of a biomechanical surrogate.

  6. Cephalometric evaluation of class-III patients with chin cap and tongue guard.

    PubMed

    Danaie, S M; Salehi, P

    2005-06-01

    The purpose of this study was to determine the effect of chin cap therapy combined with an upper tongue guard in the early treatment of class-III malocclusion on the nasomaxillary complex and mandible. The subjects of this study consisted of 40 patients aged 5-13 years (mean age of 8.5 +/- 2). All of them possessed an anterior cross bite and/or concave profile. The mean force of chin cap was determined to be 200 g on each side for 18 h/day and the mean treatment period was 22 months. The cephalometric analyses including skeletal, dental, and soft tissue analysis were carried out before and after treatment. The analysis of the cephalometric measurements revealed a negative correlation between the combination effects of chin cap therapy upper tongue guard. This effect appeared in the early stages of treatment. It was a case-control study and Wilcoxon test was used for statistical analysis. The comparison of dependent variables revealed that skeletal effects of chin cap therapy were more than dental and soft tissue effects. Changes in the upper and lower pharyngeal spaces were not significant. A reduction of nasolabial angle occurred due to the protrusion of upper incisors. Finally, it was shown that the combination of chin cap and upper tongue guard could be more effective in the early treatment.

  7. [Cortical mapping and neurophysiological monitoring during resection of an arteriovenous malformation in the rolandic region].

    PubMed

    Vega-Zelaya, Lorena; Pedrosa-Sánchez, Manuel; Pastor, Jesús

    2014-07-01

    INTRODUCTION. Surgery of arteriovenous malformations of eloquent areas has a significant risk of causing severe neurological deficits. CASE REPORT. A 39 years old woman having a headache, showed an arteriovenous malformation in right rolandic region. During resection, performed under general anesthesia, a neurophysiological mapping and subsequently intraoperative neurophysiological monitoring of motor and somatosensory functions was performed. The temporary closure of an artery resulted in a severe motor impairment, reversible after remove the clipping, so that artery had to be respected during the intervention. After resection, the motor and sensory responses were normal. The patient was discharged without any neurological deficits. CONCLUSION. Functional mapping and intraoperative neurophysiological monitoring were very helpful for the identification and protection of eloquent areas. The use of these techniques for resection of arteriovenous malformations located in functionally relevant areas, allows a safely surgery in patients under general anesthesia.

  8. Sleep studies in benign epilepsy of childhood with rolandic spikes. I. Sleep pathology.

    PubMed

    Clemens, B; Oláh, R

    1987-01-01

    Polygraphic all-night sleep records of 11 children with typical benign epilepsy of childhood with rolandic spikes (BERS) and those of eight nonepileptic controls were investigated with regard to sleep pathology. Basic properties of sleep organization and electromorphology were preserved in both groups. Seventeen quantitative sleep parameters were measured. Except for more waking in the BERS group, no sleep parameter showed significant differences between the BERS and the control group, but differences existed in comparison to normative values. We interpret our results as showing that in BERS epileptic neuronal malfunctioning does not affect sleep organization in a characteristic manner. The lack of detrimental interactions between epileptic neuronal behavior and pathological sleep alterations may be an additional cause of the benign course of BERS.

  9. Validation of the Tunisian version of the Roland-Morris questionnaire.

    PubMed

    Bejia, Ismail; Younes, Mohamed; Kamel, Ben Sallem; Letaief, Mondher; Touzi, Mongi; Soltani, Mohamed; Bergaoui, Naceur

    2005-03-01

    Our aim was to validate a culturally adapted, Tunisian-language version of the Roland-Morris Disability Questionnaire (RMDQ), which is a reliable evaluation instrument for low-back-pain disability. A total of 62 patients with low back pain were assessed by the questionnaire. Reliability for the 1-week test/re-test was assessed by a construction of a Bland Altman plot. Internal construct validity was assessed by Cronbach's alphatest. External construct validity was assessed by association with pain, the Schober test and the General Function Score. Sensitivity to change was determined using a t-test for paired data to compare RMDQ scores at inclusion and at completion of the therapeutic sequence of local corticosteroid injections. We also compared the questionnaire score with the General Function Score, both taken after completion of the therapeutic sequence. The constructed Bland Altman plot showed good reliability. Internal consistency of the RMDQ was found to be very good and the Cronbach's alpha test was 0.94, indicating a good internal construct validity. The questionnaire is correlated with the pain visual analogue scale (r=33; p=0.0001), with the Schober test (r=0.27; p=0.0001) and the General Function Score (r=56; p=0.0001) indicating an adequate external construct validity. The RMDQ administered after the therapeutic sequence is sensitive to change (r=0.83; p=0.000). Comparison of the questionnaire score to the General Function Score, after completion of the therapeutic sequence, was satisfactory (r=0.75; p=0.000). We conclude that the Tunisian version of the Roland-Morris questionnaire has good reliability and internal consistency. Furthermore, it has a good internal- and external construct validity and high sensitivity to change. It is an adequate and useful tool for assessing low-back-pain disability.

  10. Reconstruction of the chin using an expanded deltopectoral flap following multiple recurrences of oral cancer.

    PubMed

    Balakrishnan, Chenicheri; Hackenson, David; Balakrishnan, Anila; Elliott, David; Careaga, Daniel

    2012-01-01

    An important alternative to free tissue transfer in patients requiring correction of soft tissue chin defects are local and regional flaps, such as the pectoralis major myocutaneous flap and deltopectoral flap. With predictable vascular supply, potential for large size, and good aesthetic match for facial and cervical skin, the deltopectoral flap can offer the reconstructive surgeon additional options in patients who lack vessels suitable for free tissue transfer. The use of an expanded deltopectoral flap for a staged reconstruction of the chin in a patient with cancer recurrences, concomitant resections, radiation and multiple reconstructions is reported.

  11. Reconstruction of the chin using an expanded deltopectoral flap following multiple recurrences of oral cancer.

    PubMed

    Balakrishnan, Chenicheri; Hackenson, David; Balakrishnan, Anila; Elliott, David; Careaga, Daniel

    2012-01-01

    An important alternative to free tissue transfer in patients requiring correction of soft tissue chin defects are local and regional flaps, such as the pectoralis major myocutaneous flap and deltopectoral flap. With predictable vascular supply, potential for large size, and good aesthetic match for facial and cervical skin, the deltopectoral flap can offer the reconstructive surgeon additional options in patients who lack vessels suitable for free tissue transfer. The use of an expanded deltopectoral flap for a staged reconstruction of the chin in a patient with cancer recurrences, concomitant resections, radiation and multiple reconstructions is reported. PMID:23997595

  12. The chin as a donor site in early secondary osteoplasty: a retrospective clinical and radiological evaluation.

    PubMed

    Hoppenreijs, T J; Nijdam, E S; Freihofer, H P

    1992-04-01

    26 unilateral cleft palate patients received an autogenous bicortical chin bone graft for early reconstruction of the alveolar process. In the evaluation of the donor site, 4% of the anterior teeth showed a negative pulpal sensibility, less than 1% a peri-apical granuloma and 12% pulp canal obliteration. The tooth buds of the canines showed developmental disturbances in 6%. Exposure of unerupted canines should be avoided, and a 5 mm safety margin is advised. Based on its architecture, topographic accessibility, minimal post-operative morbidity and absence of visible scars, the chin can be considered to be a very useful donor site in bone grafting procedures.

  13. Numb chin syndrome as a manifestation of jaw metastasis diagnosed in a bone scan.

    PubMed

    Noriega, E; Sabaté-Llobera, A; Benítez, A; Martínez, G A; Rodríguez-Rubio, J; Mora, J

    2016-01-01

    In many cases, numb chin syndrome (NCS) may represent a banal pathology. However, as it can be associated with malignant processes, its presence should alert the clinician of a possible occult disease. In patients already diagnosed with cancer, it often represents an ominous sign that indicates poor prognosis, due to the rapid progress of the disease. The case is presented of a 62-year-old man diagnosed with synchronous lung and bladder cancer, who suddenly complained of numbness in the chin. The bone scan confirmed the suspicion of metastastic bone disease, and the patient died two months after the appearance of this sign.

  14. Spontaneous Osteonecrosis of the Jaw During Bisphosphonate Therapy: An Unusual Etiology of the Numb Chin Syndrome.

    PubMed

    Fusi-Schmidhauser, Tanja; Bardelli, Donata

    2016-09-01

    The numb chin syndrome is a rare manifestation of intractable pain in the palliative care setting and represents a major therapeutic challenge. The reported etiologies of the numb chin syndrome include trauma, infections, immune-mediated systemic conditions, and malignancy, both through local infiltration or compression of the inferior alveolar nerve sheath. The authors present the case of a patient with long-standing multiple myeloma, suffering from numb chin syndrome caused by a spontaneous osteonecrosis of the jaw after bisphosphonate therapy. Intractable unilateral orofacial pain over the right chin and lower lip with associated numbness and paresthesia in the distribution area of the mental nerve were the clinical features. A complex pharmacological therapy, including methadone, carbamazepine, and dexamethasone was started, with insufficient pain control. In consideration of the prevalent neuropathic etiology, the authors opted for a locoregional nerve block of the mandibular nerve with bupivacaine and clonidine. The interdisciplinary approach was successful, and the patient was discharged with satisfactory pain control. The purpose of this report is to demonstrate the complexity of the therapeutic approach, which may include pharmacological measures and interventional procedures to improve symptom management in this challenging clinical condition. PMID:27491573

  15. Seismic detections of the 15 February 2013 Chelyabinsk meteor from the dense ChinArray

    NASA Astrophysics Data System (ADS)

    Li, Lu; Wang, Baoshan; Peng, Zhigang; Wang, Weitao

    2016-07-01

    ChinArray is a dense portable broadband seismic network to cover the entire continental China, and the Phase I is deployed along the north-south seismic belt in southwest China. In this study, we analyze seismic data recorded on the ChinArray following the February 15, 2013 Chelyabinsk (Russia) meteor. This was the largest known object entering the Earth's atmosphere since the 1908 Tunguska meteor. The seismic energy radiated from this event was recorded by seismic stations worldwide including the dense ChinArray that are more than 4000 km away. The weak signal from the meteor event was contaminated by a magnitude 5.8 Tonga earthquake occurred ~20 min earlier. To test the feasibility of detecting the weak seismic signals from the meteor event, we compute vespagram and perform F-K analysis to the surface-wave data. We identify a seismic phase with back azimuth (BAZ) of 329.7° and slowness of 34.73 s/deg, corresponding to the surface wave from the Russian meteor event (BAZ ~325.97°). The surface magnitude (M S) of the meteor event is 3.94 ± 0.18. We also perform similar analysis on the data from the broadband array F-net in Japan, and find the BAZ of the surface waves to be 316.61°. With the different BAZs of ChinArray and F-net, we locate the Russian meteor event at 58.80°N, 58.72°E. The relatively large mislocation (~438 km as compared with 55.15°N, 61.41°E by others) may be a result of the bending propagation path of surface waves, which deviates from the great circle path. Our results suggest that the dense ChinArray and its subarrays could be used to detect weak signals at teleseismic distances.

  16. Seismic detections of the 15 February 2013 Chelyabinsk meteor from the dense ChinArray

    NASA Astrophysics Data System (ADS)

    Li, Lu; Wang, Baoshan; Peng, Zhigang; Wang, Weitao

    2016-08-01

    ChinArray is a dense portable broadband seismic network to cover the entire continental China, and the Phase I is deployed along the north-south seismic belt in southwest China. In this study, we analyze seismic data recorded on the ChinArray following the February 15, 2013 Chelyabinsk (Russia) meteor. This was the largest known object entering the Earth's atmosphere since the 1908 Tunguska meteor. The seismic energy radiated from this event was recorded by seismic stations worldwide including the dense ChinArray that are more than 4000 km away. The weak signal from the meteor event was contaminated by a magnitude 5.8 Tonga earthquake occurred ~20 min earlier. To test the feasibility of detecting the weak seismic signals from the meteor event, we compute vespagram and perform F-K analysis to the surface-wave data. We identify a seismic phase with back azimuth (BAZ) of 329.7° and slowness of 34.73 s/deg, corresponding to the surface wave from the Russian meteor event (BAZ ~325.97°). The surface magnitude ( M S) of the meteor event is 3.94 ± 0.18. We also perform similar analysis on the data from the broadband array F-net in Japan, and find the BAZ of the surface waves to be 316.61°. With the different BAZs of ChinArray and F-net, we locate the Russian meteor event at 58.80°N, 58.72°E. The relatively large mislocation (~438 km as compared with 55.15°N, 61.41°E by others) may be a result of the bending propagation path of surface waves, which deviates from the great circle path. Our results suggest that the dense ChinArray and its subarrays could be used to detect weak signals at teleseismic distances.

  17. Are dyslexia and dyscalculia associated with Rolandic epilepsy? A short report on ten Italian patients.

    PubMed

    Canavese, Carlotta; Rigardetto, Roberto; Viano, Vilma; Vittorini, Roberta; Bassi, Bianca; Pieri, Ilaria; Capizzi, Giorgio

    2007-12-01

    Rolandic epilepsy (RE) is the most common childhood epilepsy syndrome with a good, long-term outcome. Nevertheless, some studies indicate that children with RE have more scholastic and neuropsychological problems than controls. The purpose of this study was to describe neuropsychological findings in a small group of Italian children with RE, focusing on dyslexia and dyscalculia. Possible correlations between these findings and the age-at-onset of seizures, duration of active epilepsy, frequency, type and localization of epileptic discharges were examined. Children affected by RE, aged nine to eleven years were selected from patients admitted to the outpatient service of our Clinic. They underwent cognitive evaluation, specific evaluation for dyslexia and dyscalculia, and awake and sleep EEG recordings. We found two patients out of the ten with dyscalculia, one of whom also had characteristics of dyslexia. This small study suggests that dyscalculia and dyslexia might be more frequent than expected in children with RE. No significant correlations between this finding and EEG, seizure-frequency or age-at-onset of epilepsy were found in our patients. PMID:18077230

  18. Modulation of Rolandic Beta-Band Oscillations during Motor Simulation of Joint Actions.

    PubMed

    Ménoret, Mathilde; Bourguignon, Mathieu; Hari, Riitta

    2015-01-01

    Successful joint actions require precise temporal and spatial coordination between individuals who aim to achieve a common goal. A growing number of behavioral data suggest that to efficiently couple and coordinate a joint task, the actors have to represent both own and the partner's actions. However it is unclear how the motor system is specifically recruited for joint actions. To find out how the goal and the presence of the partner's hand can impact the motor activity during joint action, we assessed the functional state of 16 participants' motor cortex during observation and associated motor imagery of joint actions, individual actions, and non-goal-directed actions performed with either 1 or 2 hands. As an indicator of the functional state of the motor cortex, we used the reactivity of the rolandic magnetoencephalographic (MEG) beta rhythm following median-nerve stimulation. Motor imagery combined with action observation was associated with activation of the observer's motor cortex, mainly in the hemisphere contralateral to the viewed (and at the same time imagined) hand actions. The motor-cortex involvement was enhanced when the goal of the actions was visible but also, in the ipsilateral hemisphere, when the partner's hand was visible in the display. During joint action, the partner's action, in addition to the participant's own action, thus seems to be represented in the motor cortex so that it can be triggered by the mere presence of an acting hand in the peripersonal space. PMID:26151634

  19. Benign rolandic epileptiform discharges are associated with mood and behavior problems

    PubMed Central

    Sarco, Dean P.; Boyer, Katrina; Lundy-Krigbaum, Shannon M.; Takeoka, Masanori; Jensen, Frances; Gregas, Matt; Waber, Deborah P.

    2016-01-01

    Children with benign rolandic epilepsy (BRE) experience elevated rates of cognitive, behavioral, and affective problems. Frequent epileptiform spike discharges may impair behavioral functioning. To elucidate this relationship, we evaluated associations between the EEG spike frequency index (SI) and parental ratings of psychosocial adjustment and executive functioning in school-aged children with EEGs typical of BRE. Twenty-one children (6–12 years) participated. Parents completed validated questionnaires at a median of 5 months (range: 1–8) after a routine outpatient EEG. The EEG SI was calculated for wakefulness and sleep. The strength of association between the SI and behavioral variables was evaluated by simple and multivariate correlation. Higher awake and sleep SIs were associated with more symptoms of depression (P<0.001), aggression and conduct problems (P<0.01). Higher sleep SI was associated with executive dysfunction and anxiety (P<0.05). Symptoms of hyperactivity and inattention had no correlation. Increased epileptiform activity in children with BRE may predict higher rates of mood and behavioral problems. PMID:21862414

  20. The spectrum from BCECTS to LKS: The Rolandic EEG trait-impact on cognition.

    PubMed

    Stephani, Ulrich; Carlsson, Goran

    2006-01-01

    The laboratory hallmark of BCECTS is the rolandic discharge (RD) in the EEG of patients, occurring in a characteristic topographical, vigilance-related, event-related, and age-related pattern, disappearing during puberty. RDs are present in 2% of healthy children. About 8% of children with RDs have epilepsy. An increased prevalence rate of RDs is found in children with cognitive and behavioral disorders, with headaches and some genetic syndromes. In some patients, the cognitive disorders are transient but in others they are progressive, resulting in stable mental retardation after puberty. A recent study of 36 BCECTS patients addressed the following questions. (1) the possible relationship between the severity of RDs and the neuropsychological deficits; (2) the profile of neuropsychological deficits; (3) changes of cognition related to EEG changes; and (4) effects of therapy. No correlation was found between global IQ and the severity of the RDs. All the children had at least one specific learning disorder (sometimes long-lasting). When the children were treated, a correlation between cognitive and EEG improvement could not be demonstrated. Recently, 21 patients without epilepsy but with attention deficit and hyperactivity and/or learning disorders were studied: an open treatment trial with sulthiame resulted in improved sustained and selective attention. The neurobiology of RDs and their relationship to cognitive dysfunction and epilepsy requires further study.

  1. Altered Rolandic Gamma-Band Activation Associated with Motor Impairment and Ictal Network Desynchronization in Childhood Epilepsy

    PubMed Central

    Doesburg, Sam M.; Ibrahim, George M.; Smith, Mary Lou; Sharma, Rohit; Viljoen, Amrita; Chu, Bill; Rutka, James T.; Snead, O. Carter; Pang, Elizabeth W.

    2013-01-01

    Epilepsy is associated with an abnormal expression of neural oscillations and their synchronization across brain regions. Oscillatory brain activation and synchronization also play an important role in cognition, perception and motor control. Childhood epilepsy is associated with a variety of cognitive and motor deficits, but the relationship between altered functional brain responses in various frequency ranges and functional impairment in these children remains poorly understood. We investigated functional magnetoencephalographic (MEG) responses from motor cortex in multiple functionally relevant frequency bands following median nerve stimulation in twelve children with epilepsy, including four children with motor impairments. We demonstrated that children with motor impairments exhibit an excessive gamma-band response from Rolandic cortex, and that the magnitude of this Rolandic gamma response is negatively associated with motor function. Abnormal responses from motor cortex were also associated with ictal desynchronization of oscillations within Rolandic cortex measured using intracranial EEG (iEEG). These results provide the evidence that ictal disruption of motor networks is associated with an altered functional response from motor cortex, which is in turn associated with motor impairment. PMID:23383007

  2. Fiddler's neck: Chin rest-associated irritant contact dermatitis and allergic contact dermatitis in a violin player.

    PubMed

    Caero, Jennifer E; Cohen, Philip R

    2012-09-01

    Fiddler's neck refers to an irritant contact dermatitis on the submandibular neck of violin and viola players and an allergic contact dermatitis to nickel from the bracket attaching the violin to the chin rest on the violinist's supraclavicular neck. A 26-year-old woman developed submandibular and supraclavicular left neck lesions corresponding to the locations of the chin rest and bracket that was attached to her violin that held it against her neck when she played. Substitution of a composite chin rest, which did not contain nickel, and the short-term application of a low potency topical corticosteroid cream, resulted in complete resolution of the allergic contact dermatitis supraclavicular neck lesion. The irritant contact dermatitis submandibular neck lesion persisted. In conclusion, violin players are predisposed to developing irritant contact dermatitis or allergic contact dermatitis from the chin rest. We respectfully suggest that the submandibular neck lesions from contact with the chin rest be referred to as 'fiddler's neck - type 1,' whereas the supraclavicular neck lesions resulting from contact of the bracket holding the chin rest in place be called 'fiddler's neck - type 2.' A composite chin rest should be considered in patients with a preceding history of allergic contact dermatitis to nickel. PMID:23031377

  3. Fiddler's neck: Chin rest-associated irritant contact dermatitis and allergic contact dermatitis in a violin player.

    PubMed

    Caero, Jennifer E; Cohen, Philip R

    2012-09-01

    Fiddler's neck refers to an irritant contact dermatitis on the submandibular neck of violin and viola players and an allergic contact dermatitis to nickel from the bracket attaching the violin to the chin rest on the violinist's supraclavicular neck. A 26-year-old woman developed submandibular and supraclavicular left neck lesions corresponding to the locations of the chin rest and bracket that was attached to her violin that held it against her neck when she played. Substitution of a composite chin rest, which did not contain nickel, and the short-term application of a low potency topical corticosteroid cream, resulted in complete resolution of the allergic contact dermatitis supraclavicular neck lesion. The irritant contact dermatitis submandibular neck lesion persisted. In conclusion, violin players are predisposed to developing irritant contact dermatitis or allergic contact dermatitis from the chin rest. We respectfully suggest that the submandibular neck lesions from contact with the chin rest be referred to as 'fiddler's neck - type 1,' whereas the supraclavicular neck lesions resulting from contact of the bracket holding the chin rest in place be called 'fiddler's neck - type 2.' A composite chin rest should be considered in patients with a preceding history of allergic contact dermatitis to nickel.

  4. Chinrest pressure in violin playing: type of music, chin rest, and shoulder pad as possible mediators.

    PubMed

    Okner, M; Kernozek, T

    1997-04-01

    INTRODUCTION:: This study was conducted to determine if there are differences in pressure on a violin chin rest during performance due to changes in shoulder pads, chin rests, or pieces of music performed. It was also hypothesized that these differences would correlate with anthropometric measurements made of the subjects' necks and shoulders. METHODS::: A Novel EMED pad was used over the chin rest, containing 120 sensors, each one centimetre squared. The sampling rate was 50 Hz. A total of ten subjects, all professional violinists, performed excerpts from a Bruch violin concerto and a Handel sonata. Anthropometric measurements were made of the subjects' necks and shoulders. Each subject began by using his own violin with his usual shoulder pad and chin rest set-up, and then with the author's violin. Two different shoulder pads and three different chin rests were placed on the violin, in all possible combinations, for both pieces of music. This resulted in a total of fourteen conditions given in randomized order for each subject. Subjects were asked to give verbal feedback regarding the comfort and ease of playing of each shoulder pad and chin rest. Data was collected for three trials of each condition, and a mean for the three trials was obtained for each dependent variable. The five dependent variables were: peak pressure, maximum force, pressure/time integral and force/time integral, and total contact area. Intraclass coefficients of reliability were calculated for the dependent variables. Pearson's correlation coefficients were computed to determine if there were significant relationships between the five dependent variables and violin height, shoulder width, and neck length. RESULTS:: Pressure/time integral achieved the highest reliability with a coefficient of 0.9310, followed by peak pressure at 0.9152, force/time integral at 0.8817, maximum force at 0.8685, and total area at 0.8571. Multivariate analysis of variance detected significant differences in

  5. Chinrest pressure in violin playing: type of music, chin rest, and shoulder pad as possible mediators.

    PubMed

    Okner, M; Kernozek, T

    1997-04-01

    INTRODUCTION:: This study was conducted to determine if there are differences in pressure on a violin chin rest during performance due to changes in shoulder pads, chin rests, or pieces of music performed. It was also hypothesized that these differences would correlate with anthropometric measurements made of the subjects' necks and shoulders. METHODS::: A Novel EMED pad was used over the chin rest, containing 120 sensors, each one centimetre squared. The sampling rate was 50 Hz. A total of ten subjects, all professional violinists, performed excerpts from a Bruch violin concerto and a Handel sonata. Anthropometric measurements were made of the subjects' necks and shoulders. Each subject began by using his own violin with his usual shoulder pad and chin rest set-up, and then with the author's violin. Two different shoulder pads and three different chin rests were placed on the violin, in all possible combinations, for both pieces of music. This resulted in a total of fourteen conditions given in randomized order for each subject. Subjects were asked to give verbal feedback regarding the comfort and ease of playing of each shoulder pad and chin rest. Data was collected for three trials of each condition, and a mean for the three trials was obtained for each dependent variable. The five dependent variables were: peak pressure, maximum force, pressure/time integral and force/time integral, and total contact area. Intraclass coefficients of reliability were calculated for the dependent variables. Pearson's correlation coefficients were computed to determine if there were significant relationships between the five dependent variables and violin height, shoulder width, and neck length. RESULTS:: Pressure/time integral achieved the highest reliability with a coefficient of 0.9310, followed by peak pressure at 0.9152, force/time integral at 0.8817, maximum force at 0.8685, and total area at 0.8571. Multivariate analysis of variance detected significant differences in

  6. Method of induction could affect emotional outcomes: comment on markey, chin, vanepps, and loewenstein (2014 ).

    PubMed

    Bench, Shane W; Yaugher, Ashley C; Lench, Heather C

    2015-04-01

    Markey, Chin, Vanepps, and Loewenstein (2014) demonstrated six methods for the induction of boredom. However, a clear and testable definition of boredom should be established prior to experimental manipulation of the construct. Defining boredom from a functional emotion perspective is one approach that affords a definition separable from the outcomes associated with boredom and insight into which manipulations may effectively target the construct. PMID:25730196

  7. Incidence of cleft chin among the Adi and Apatani of Arunachal Pradesh, Northeast India.

    PubMed

    Dass, U

    1985-09-01

    The occurrence of cleft chin was studied among five endogamous groups (Padam, Minyong, Pasi, Gallong, Apatani) of Arunachal Pradesh, Northeast India. The incidence of this trait is low in all the groups. Thus, the populations are characterized by low frequencies of the gene Cl. Bisexual difference is significant only among the Minyong. While compared with other populations from Northeast India, the Mongoloid populations were found to be distinct from the only caste population, which has been investigated so far.

  8. Control of a trackball by the chin for communication applications, with and without neck movements.

    PubMed

    Jacobs, R; Hendrickx, E; Van Mele, I; Edwards, K; Verheust, M; Spaepen, A; van Steenberghe, D

    1997-03-01

    The overall aim was to evaluate whether a trackball could be used for communication by people who cannot speak due to severe motor impairment. The precision of trackball control by isolated jaw movements or a combination of jaw and head movements was evaluated in 18 healthy physical-education students, free of overt symptoms of craniomandibular dysfunction. The participants were asked to operate a trackball using the chin to type a standard text of four short sentences. There were two experimental situations: nine participants performed the typewriting task with their heads fixed; the other nine performed this task with free head movements. Trackball operation moved to the cursor over an alphabetical keyboard displayed on a computer screen and character selection was made by depression of the left-hand click button using the chin. Participants were asked to perform the task as quickly and accurately as possible. Result showed that those with free head movement typed the test significantly faster than those restricted to using only their jaw muscles. The mean time per character selection was 2.4 s (SD 0.3) for the group with free head movement and 2.7 s (SD 0.3) for the group using only jaw muscles. Group scores were not significantly different with regard to accuracy. It is suggested that a chin-operated trackball could be used for communication applications both with and without neck movements. PMID:9188991

  9. The effectiveness of the head-turn-plus-chin-down maneuver for eliminating vallecular residue.

    PubMed

    Nagy, Ahmed; Peladeau-Pigeon, Melanie; Valenzano, Teresa Josephine; Namasivayam, Ashwini Marini; Steele, Catriona Margaret

    2016-04-01

    Purpose When swallowing efficiency is impaired, residue accumulates in the pharynx. Cued or spontaneous swallows in the head neutral position do not always successfully clear residue. We investigated the impact of a novel maneuver on residue clearance by combining a head turn with the chin down posture. Methods Data were collected from 26 participants who demonstrated persistent vallecular residue after an initial head neutral clearance swallow in videofluoroscopy. Participants were cued to perform a head-turn-plus-chin-down swallow, with the direction of head turn randomized. Pixel-based measures of residue in the vallecular space before and after the maneuver were made on still frame lateral images using ImageJ software. Measures of % full and the Normalized Residue Ratio Scale (NRRS) were extracted. Univariate analyses of variance were used to detect significant reductions in residue. Results On average, pre-maneuver measures showed residue filling 56-73% of the valleculae, depending on stimulus consistency (NRRS scores: 0.2-0.4). More than 80% of pre-swallow measures displayed NRRS ratios > 0.06, a threshold previously linked to increased risk of post-swallow aspiration. Conclusion The head-turn-plus-chin-down maneuver achieved significant reductions in residue for thin and nectar-thick fluids, suggesting that this maneuver can be effective in reducing persistent vallecular residue with these consistencies. PMID:27191873

  10. 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy.

    PubMed

    Reinthaler, Eva M; Lal, Dennis; Lebon, Sebastien; Hildebrand, Michael S; Dahl, Hans-Henrik M; Regan, Brigid M; Feucht, Martha; Steinböck, Hannelore; Neophytou, Birgit; Ronen, Gabriel M; Roche, Laurian; Gruber-Sedlmayr, Ursula; Geldner, Julia; Haberlandt, Edda; Hoffmann, Per; Herms, Stefan; Gieger, Christian; Waldenberger, Melanie; Franke, Andre; Wittig, Michael; Schoch, Susanne; Becker, Albert J; Hahn, Andreas; Männik, Katrin; Toliat, Mohammad R; Winterer, Georg; Lerche, Holger; Nürnberg, Peter; Mefford, Heather; Scheffer, Ingrid E; Berkovic, Samuel F; Beckmann, Jacques S; Sander, Thomas; Jacquemont, Sebastien; Reymond, Alexandre; Zimprich, Fritz; Neubauer, Bernd A

    2014-11-15

    Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy. Its molecular basis is largely unknown and a complex genetic etiology is assumed in the majority of affected individuals. The present study tested whether six large recurrent copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2, 16p13.11 and 22q11.2 previously associated with neurodevelopmental disorders also increase risk of RE. Our association analyses revealed a significant excess of the 600 kb genomic duplication at the 16p11.2 locus (chr16: 29.5-30.1 Mb) in 393 unrelated patients with typical (n = 339) and atypical (ARE; n = 54) RE compared with the prevalence in 65,046 European population controls (5/393 cases versus 32/65,046 controls; Fisher's exact test P = 2.83 × 10(-6), odds ratio = 26.2, 95% confidence interval: 7.9-68.2). In contrast, the 16p11.2 duplication was not detected in 1738 European epilepsy patients with either temporal lobe epilepsy (n = 330) and genetic generalized epilepsies (n = 1408), suggesting a selective enrichment of the 16p11.2 duplication in idiopathic focal childhood epilepsies (Fisher's exact test P = 2.1 × 10(-4)). In a subsequent screen among children carrying the 16p11.2 600 kb rearrangement we identified three patients with RE-spectrum epilepsies in 117 duplication carriers (2.6%) but none in 202 carriers of the reciprocal deletion. Our results suggest that the 16p11.2 duplication represents a significant genetic risk factor for typical and atypical RE. PMID:24939913

  11. Delayed convergence between brain network structure and function in rolandic epilepsy

    PubMed Central

    Besseling, René M. H.; Jansen, Jacobus F. A.; Overvliet, Geke M.; van der Kruijs, Sylvie J. M.; Ebus, Saskia C. M.; de Louw, Anton J. A.; Hofman, Paul A. M.; Aldenkamp, Albert P.; Backes, Walter H.

    2014-01-01

    Introduction: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. Methods: Twenty-two children with RE (age, mean ± SD: 11.3 ± 2.0 y) and 22 healthy controls (age 10.5 ± 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01–0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. Results: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. Conclusion: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of

  12. Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility

    PubMed Central

    Mellish, Louise C; Dunkley, Colin; Ferrie, Colin D; Pal, Deb K

    2015-01-01

    Background The evidence base for management of childhood epilepsy is poor, especially for the most common specific syndromes such as rolandic epilepsy (RE) and Panayiotopoulos syndrome (PS). Considerable international variation in management and controversy about non-treatment indicate the need for high quality randomised controlled trials (RCT). The aim of this study is, therefore, to describe current UK practice and explore the feasibility of different RCT designs for RE and PS. Methods We conducted an online survey of 590 UK paediatricians who treat epilepsy. Thirty-two questions covered annual caseload, investigation and management practice, factors influencing treatment, antiepileptic drug preferences and hypothetical trial design preferences. Results 132 responded (22%): 81% were paediatricians and 95% at consultant seniority. We estimated, annually, 751 new RE cases and 233 PS cases. Electroencephalography (EEG) is requested at least half the time in approximately 70% of cases; MRI brain at least half the time in 40%–65% cases and neuropsychological evaluation in 7%–8%. Clinicians reported non-treatment in 40%: main reasons were low frequency of seizures and parent/child preferences. Carbamazepine is the preferred older, and levetiracetam the preferred newer, RCT arm. Approximately one-half considered active and placebo designs acceptable, choosing seizures as primary and cognitive/behavioural measures as secondary outcomes. Conclusions Management among respondents is broadly in line with national guidance, although with possible overuse of brain imaging and underuse of EEG and neuropsychological assessments. A large proportion of patients in the UK remains untreated, and clinicians seem amenable to a range of RCT designs, with carbamazepine and levetiracetam the preferred active drugs. PMID:25202134

  13. 16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy.

    PubMed

    Reinthaler, Eva M; Lal, Dennis; Lebon, Sebastien; Hildebrand, Michael S; Dahl, Hans-Henrik M; Regan, Brigid M; Feucht, Martha; Steinböck, Hannelore; Neophytou, Birgit; Ronen, Gabriel M; Roche, Laurian; Gruber-Sedlmayr, Ursula; Geldner, Julia; Haberlandt, Edda; Hoffmann, Per; Herms, Stefan; Gieger, Christian; Waldenberger, Melanie; Franke, Andre; Wittig, Michael; Schoch, Susanne; Becker, Albert J; Hahn, Andreas; Männik, Katrin; Toliat, Mohammad R; Winterer, Georg; Lerche, Holger; Nürnberg, Peter; Mefford, Heather; Scheffer, Ingrid E; Berkovic, Samuel F; Beckmann, Jacques S; Sander, Thomas; Jacquemont, Sebastien; Reymond, Alexandre; Zimprich, Fritz; Neubauer, Bernd A

    2014-11-15

    Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy. Its molecular basis is largely unknown and a complex genetic etiology is assumed in the majority of affected individuals. The present study tested whether six large recurrent copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2, 16p13.11 and 22q11.2 previously associated with neurodevelopmental disorders also increase risk of RE. Our association analyses revealed a significant excess of the 600 kb genomic duplication at the 16p11.2 locus (chr16: 29.5-30.1 Mb) in 393 unrelated patients with typical (n = 339) and atypical (ARE; n = 54) RE compared with the prevalence in 65,046 European population controls (5/393 cases versus 32/65,046 controls; Fisher's exact test P = 2.83 × 10(-6), odds ratio = 26.2, 95% confidence interval: 7.9-68.2). In contrast, the 16p11.2 duplication was not detected in 1738 European epilepsy patients with either temporal lobe epilepsy (n = 330) and genetic generalized epilepsies (n = 1408), suggesting a selective enrichment of the 16p11.2 duplication in idiopathic focal childhood epilepsies (Fisher's exact test P = 2.1 × 10(-4)). In a subsequent screen among children carrying the 16p11.2 600 kb rearrangement we identified three patients with RE-spectrum epilepsies in 117 duplication carriers (2.6%) but none in 202 carriers of the reciprocal deletion. Our results suggest that the 16p11.2 duplication represents a significant genetic risk factor for typical and atypical RE.

  14. Alveolar and Skeletal Chin Dimensions Associated with Lower Facial Height Among Different Divergent Patterns

    PubMed Central

    Khan, MD Yaser Ahmed; Kishore, M.S.V; Rachala, Madhukar Reddy; Sashidhar, Nagam Reddy

    2016-01-01

    Introduction Alveolar and skeletal chin dimensions with facial height have an impact on diagnosis and treatment planning in orthodontic patients and serves as a reference landmark for facial aesthetics. Aim To evaluate the alveolar and skeleton chin dimensions among different divergent patterns, to evaluate the lower face height in different divergent growth patterns, to give an estimate to the oral surgeon for any adjunctive procedure. Materials and Methods The study includes a total sample of 45 non-growing individuals (26 males and 19 females) from the archival records of the Orthodontic Department with age ranging between 18-25 years, classified into different divergent patterns based on the mandibular plane angle. The sample was divided into three groups, of which 15 patients in each group were evaluated: Group-1: Normodivergent, Group-2: Hypodivergent and Group-3: Hyperdivergent patterns respectively. Standardized digital lateral cephalograms and antero-posterior cephalograms of these patients were obtained in Natural Head Position (NHP). Results The results of the retrospective cephalometeric study were statistically analyzed by using ANOVA and Tukey’s multiple post hoc test which showed that hard tissue chin measurement were greater in hypodivergent group (13.7mm) and the increased lower facial height showed statistically significant difference in high mandibular plane angle group (59.6mm). In antero-posterior cephalograms the transverse width showed statistically significant difference in normodivergent group (32.60mm). Conclusion The anterio-posterior width of the symphysis was higher in hypodivergent growth pattern, whereas vertical height of the symphysis was greater in hyperdivergent group. The lower facial height among three groups showed statistically significant difference among hyperdivergent group. In comparison of all the three groups in Anterio-Posterior (AP) cephalograms, statistically significant difference was noted in normodivergent group

  15. Chin and prejowl augmentation in the management of the aging jawline.

    PubMed

    Romo, Thomas; Yalamanchili, Haresh; Sclafani, Anthony P

    2005-02-01

    The effects of aging in the lower face and neck are reflected in the contour of the jawline. Soft tissue atrophy, the formation of jowls, and retrusion of the chin are all age-associated changes that contrast starkly with the smooth harmony of a young lower face. These soft tissue changes in the jawline are exacerbated by the effects of aging on the bony portion of the mandible. Bone resorption of the mandible seen with aging can lead to the development of a hypoplastic mentum and the formation of an anterior mandibular groove. Rhytidectomy serves to address the soft tissue changes from aging but cannot counter the effects of aging on the bony mandible itself. Understanding the effects of bone resorption on the aging mandible allows the facial plastic surgeon to augment the mandible appropriately to achieve a more effective rejuvenation of the lower face. The aging process in the mandible and the development of the prejowl sulcus are reviewed. The use of chin and prejowl augmentation as a valuable adjuvant to facelift surgery is discussed.

  16. Chin-sternum-heart syndrome type of injury observed in a pedestrian victim of car traffic accident.

    PubMed

    Furumiya, Junichi; Nishimura, Hiroyuki; Nakanishi, Akinori; Hashimoto, Yoshiaki

    2009-04-01

    We report an autopsy case of a pedestrian victim of car traffic accident with the chin-sternum-heart syndrome type of injury. A drunken man who lay on the road was run over by a car. He died immediately at the scene. The autopsy findings were as follows: large scalp lacerations, abrasions in the chin and the sternal region, a transverse fracture of the sternum, ruptures of the heart, ruptures of the ascending and descending aortae, rupture and hemorrhage of the nuchal muscle, ring fracture of the base of the skull, subarachnoid hemorrhage at the base of the brain, multiple rib fractures, anterior compression fracture of the 11th thoracic vertebra, and small lacerations of the liver. Blood ethanol level was 2.92 mg/g. These findings indicate that there was hyperflexion of the neck and then the victim's heart was strongly compressed and ruptured by the collision of the chin with the sternal region of the chest.

  17. Placement of endosteal implants combined with chin bone onlay graft for dental reconstruction in patients with grafted alveolar clefts.

    PubMed

    Fukuda, M; Takahashi, T; Yamaguchi, T; Kochi, S

    1998-12-01

    Endosteal implants were inserted into grafted alveoli after particulate cancellous bone and marrow grafting in seven patients with cleft lip or palate in conjunction with simultaneous chin bone onlay grafting. In these patients, the alveolar bone height of the bony bridge was insufficient when evaluated by both computed tomographic and periapical radiographic images. The age at first implant surgery ranged from 14 to 28 years. Although four of the seven patients had an uneventful course, three had wound dehiscence, and in all but one of them the exposed chin bone underwent partial or total necrosis. Ultimately all seven implants integrated into the bone, and the alveolar bone height was increased in all but one patient. The results indicate that chin bone onlay grafting with simultaneous implant insertion is useful in patients with cleft lip or palate with insufficient alveolar bone height.

  18. Revealing Additional Dimensions of Globalisation and Cultural Hegemony: A Response to Roland S. Persson's Call for Cultural Sensitivity in Gifted Studies

    ERIC Educational Resources Information Center

    Ambrose, Don

    2012-01-01

    In this commentary, the author finds the interdisciplinary approach of Roland S. Persson's (2012a) target article refreshing. Persson's (2012a) additional emphases on ethnocentricity, cultural bias and strong threads of influence from the global economy also are helpful. They shed light on some strong contextual influences that shape the…

  19. Comparison of modified chin lift technique with EC technique for mask ventilation in adult apneic patients

    PubMed Central

    Rajappa, Geetha C.; Parate, Leena Harshad; Tejesh, C. A.; Prathima, P. T.

    2016-01-01

    Background: Mask ventilation (MV) is an essential basic life support skill. We used chin lift maneuver for MV and named as modified chin lift technique (MCL). EC technique is most common technique used for MV. Aims: The aim of this study is to compare the efficacy of both techniques for MV in term of expired tidal volume (TV). Secondarily, we also assessed the effect of experience on the performance of these both techniques. Settings and Design: The study area was operation theater of our hospital. This was a prospective, randomized, crossover study. Methods: A total 108 adults undergoing elective surgery under general anesthesia were recruited. In all patients, operators (novice/anesthesiologist) randomly performed both techniques either to start with EC or MCL technique. Expired TV was measured for one minute for each technique. Statistical Analysis: Paired t-test was used to compare TV. Results and Conclusion: The mean TV was significantly higher in MCL group than EC group (528.08 [104.96] ml vs. 483.39 [103] ml; P < 0.001). The novice (521.89 [117.9] ml vs. 478.70 [130.29] ml; P < 0.001) as well as anesthesiologists (534.27 [110.85] ml vs. 488.08 [111.6] ml; P < 0.001) was able to generate significantly more TV with MCL technique than EC technique. The TV did not differ significantly between novice and anesthesiologist for EC technique (P = 0.474) or MCL technique (P = 0.187). Novices as well as anesthesiologist felt MCL technique more satisfactory (70%). Clinical Trial Registration: CTRI/2016/04/006874. PMID:27746566

  20. Growth characteristics underlying lack of a chin in pigs: a histomorphometric study

    PubMed Central

    Price, J.; Tee, B. C.; Vig, K.; Shanker, S.; Kennedy, K.; Sun, Z.

    2015-01-01

    Objectives Despite similar mandibular growth to that of humans, pigs lack a chin projection as shown in most humans. To understand whether this divergence is contributed to differences in local symphyseal growth, this project characterized bone modeling activities at the symphyseal surfaces of juvenile pigs. Material and Methods Symphyseal specimens from 2 age groups (4- and 6-month-old, n=10) were processed into histological sections with and without decalcification, which were assessed for surface mineral apposition and bone resorption, respectively. In a blinded fashion, measurements of four parameters (MAR: mineral apposition rate, MAZ: mineral apposition zone; ES/BS: eroded surface; OC.N/BS: osteoclast number) were obtained and tested by a multivariate two-way mixed-model analyses of variance (MANOVA) for the differences between symphyseal regions and ages. Results Qualitatively, pig symphyseal labial and lingual surfaces were horizontally oriented and characterized by mineral apposition and bone resorption, respectively. Quantitatively, labial mineral apposition tended to be greater rostrally than caudally at 4 months, which became greater caudally than rostrally at 6 months (region/age interactions: p=0.127 for MAR, p=0.012 for MAZ). Lingual bone resorption tended to be greater caudally than rostrally, but only ES/BS measurements was significant (p=0.039) regardless of age while OC.N/BS measurements varied with ages and regions (age/region interaction, p=0.087). Conclusions Insufficient differential in symphyseal surface modeling between the labial-caudal and labial-rostral regions contributes to the lack of chin projection in the pig. PMID:26250613

  1. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo.

    PubMed

    Kumfer, Kraig T; Cook, Steven J; Squirrell, Jayne M; Eliceiri, Kevin W; Peel, Nina; O'Connell, Kevin F; White, John G

    2010-01-15

    The anterior-posterior axis of the Caenorhabditis elegans embryo is elaborated at the one-cell stage by the polarization of the partitioning (PAR) proteins at the cell cortex. Polarization is established under the control of the Rho GTPase RHO-1 and is maintained by the Rho GTPase CDC-42. To understand more clearly the role of the Rho family GTPases in polarization and division of the early embryo, we constructed a fluorescent biosensor to determine the localization of CDC-42 activity in the living embryo. A genetic screen using this biosensor identified one positive (putative guanine nucleotide exchange factor [GEF]) and one negative (putative GTPase activating protein [GAP]) regulator of CDC-42 activity: CGEF-1 and CHIN-1. CGEF-1 was required for robust activation, whereas CHIN-1 restricted the spatial extent of CDC-42 activity. Genetic studies placed CHIN-1 in a novel regulatory loop, parallel to loop described previously, that maintains cortical PAR polarity. We found that polarized distributions of the nonmuscle myosin NMY-2 at the cell cortex are independently produced by the actions of RHO-1, and its effector kinase LET-502, during establishment phase and CDC-42, and its effector kinase MRCK-1, during maintenance phase. CHIN-1 restricted NMY-2 recruitment to the anterior during maintenance phase, consistent with its role in polarizing CDC-42 activity during this phase.

  2. Effect on the contour of bone and soft tissue one year after harvesting chin bone for alveolar cleft repair.

    PubMed

    Dik, E A; de Ruiter, A P; van der Bilt, A; Koole, R

    2010-10-01

    In this study the authors evaluate and quantify the residual bony defect in the mandibular symphysis and its effect on the soft tissue contour a minimum of 1 year after harvesting chin bone. 59 ASA I cleft lip and palate patients, aged 8-19 years were included. In all patients an autologous bone graft from the mandibular symphysis was harvested for transplantation to the alveolar cleft. Lateral cephalograms were used to measure the donor site defects, and the effects on the soft tissue contour. An evident residual defect was measured at the donor site 1 year after harvesting chin bone. A significant relation was seen between age at time of surgery and size of the defect 1 year postoperatively. In older patients a larger defect remained. Using the current surgical technique of harvesting chin bone, complete bony repair of the defect was not achieved. This study shows postoperatively persisting defects that comprise on average 14% of the original peroperative defects. A significant increase in soft tissue thickness was seen at the mandibular symphysis at a minimum of 1 year postoperatively. These changes in the soft tissue chin contour 1 year after harvesting bone are similar to normal growth changes.

  3. Children with Multiple Disabilities and Minimal Motor Behavior Using Chin Movements to Operate Microswitches to Obtain Environmental Stimulation

    ERIC Educational Resources Information Center

    Lancioni, Giulio E.; O'Reilly, Mark F.; Singh, Nirbhay N.; Sigafoos, Jeff; Tota, Alessia; Antonucci, Massimo; Oliva, Doretta

    2006-01-01

    In these two studies, two children with multiple disabilities and minimal motor behavior were assessed to see if they could use chin movements to operate microswitches to obtain environmental stimulation. In Study I, we applied an adapted version of a recently introduced electronic microswitch [Lancioni, G. E., O'Reilly, M. F., Singh, N. N.,…

  4. GM2 gangliosidosis associated with a HEXA missense mutation in Japanese Chin dogs: a potential model for Tay Sachs disease.

    PubMed

    Sanders, Douglas N; Zeng, Rong; Wenger, David A; Johnson, Gary S; Johnson, Gayle C; Decker, Jared E; Katz, Martin L; Platt, Simon R; O'Brien, Dennis P

    2013-01-01

    GM2 gangliosidosis is a fatal lysosomal storage disease caused by a deficiency of β-hexosaminidase (EC 3.2.1.52). There are two major isoforms of the enzyme: hexosaminidase A composed of an α and a β subunit (encoded by HEXA and HEXB genes, respectively); and, hexosaminidase B composed of two β subunits. Hexosaminidase A requires an activator protein encoded by GM2A to catabolize GM2 ganglioside, but even in the absence of the activator protein, it can hydrolyze the synthetic substrates commonly used to assess enzyme activity. GM2 gangliosidosis has been reported in Japanese Chin dogs, and we identified the disease in two related Japanese Chin dogs based on clinical signs, histopathology and elevated brain GM2 gangliosides. As in previous reports, we found normal or elevated hexosaminidase activity when measured with the synthetic substrates. This suggested that the canine disease is analogous to human AB variant of G(M2) gangliosidosis, which results from mutations in GM2A. However, only common neutral single nucleotide polymorphisms were found upon sequence analysis of the canine ortholog of GM2A from the affected Japanese Chins. When the same DNA samples were used to sequence HEXA, we identified a homozygous HEXA:c967G>A transition which predicts a p.E323K substitution. The glutamyl moiety at 323 is known to make an essential contribution to the active site of hexosaminidase A, and none of the 128 normal Japanese Chins and 92 normal dogs of other breeds that we tested was homozygous for HEXA:c967A. Thus it appears that the HEXA:c967G>A transition is responsible for the GM2 gangliosidosis in Japanese Chins.

  5. GM2 gangliosidosis associated with a HEXA missense mutation in Japanese Chin dogs: a potential model for Tay Sachs disease.

    PubMed

    Sanders, Douglas N; Zeng, Rong; Wenger, David A; Johnson, Gary S; Johnson, Gayle C; Decker, Jared E; Katz, Martin L; Platt, Simon R; O'Brien, Dennis P

    2013-01-01

    GM2 gangliosidosis is a fatal lysosomal storage disease caused by a deficiency of β-hexosaminidase (EC 3.2.1.52). There are two major isoforms of the enzyme: hexosaminidase A composed of an α and a β subunit (encoded by HEXA and HEXB genes, respectively); and, hexosaminidase B composed of two β subunits. Hexosaminidase A requires an activator protein encoded by GM2A to catabolize GM2 ganglioside, but even in the absence of the activator protein, it can hydrolyze the synthetic substrates commonly used to assess enzyme activity. GM2 gangliosidosis has been reported in Japanese Chin dogs, and we identified the disease in two related Japanese Chin dogs based on clinical signs, histopathology and elevated brain GM2 gangliosides. As in previous reports, we found normal or elevated hexosaminidase activity when measured with the synthetic substrates. This suggested that the canine disease is analogous to human AB variant of G(M2) gangliosidosis, which results from mutations in GM2A. However, only common neutral single nucleotide polymorphisms were found upon sequence analysis of the canine ortholog of GM2A from the affected Japanese Chins. When the same DNA samples were used to sequence HEXA, we identified a homozygous HEXA:c967G>A transition which predicts a p.E323K substitution. The glutamyl moiety at 323 is known to make an essential contribution to the active site of hexosaminidase A, and none of the 128 normal Japanese Chins and 92 normal dogs of other breeds that we tested was homozygous for HEXA:c967A. Thus it appears that the HEXA:c967G>A transition is responsible for the GM2 gangliosidosis in Japanese Chins. PMID:23266199

  6. Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes.

    PubMed

    Baglietto, M G; Battaglia, F M; Nobili, L; Tortorelli, S; De Negri, E; Calevo, M G; Veneselli, E; De Negri, M

    2001-06-01

    Nine children (five males, four females; age range 6 years 1 month to 11 years 1 month) affected by benign epilepsy of childhood with centrotemporal or Rolandic spikes (BECRS) with EEG evidence of marked activation of interictal epileptic discharges (IEDs) during sleep, and nine unaffected control children matched for age, sex, and socioeconomic status, were enrolled in a prospective study. At the time of detection of IED activation during sleep, patients showed a mean Full-Scale IQ score within the normal range, but significantly below that of control participants; neuropsychological assessment revealed disorders in visuospatial short-term memory (Corsi's Block Tapping Test), attention, and cognitive flexibility (Trail Making Test and Stroop Color-Word Test), picture naming, and fluency (Benton's Naming Test and Word Fluency), visuoperceptual skill (Ghent-Poppelreuter and Street Gestalt Completion Tests) and visuomotor coordination (Bender Test). After detection of IED activation during sleep, children were followed up for 2 years. At the time of IED remission (T1), neuropsychological re-evaluation showed a notable increase in IQ score and a significant improvement (t-test: p<0.007) in visuomotor coordination, non-verbal short-term memory, sustained attention and mental flexibility, picture naming, and visual-perceptual performance. At T1, patients' performance did not differ from the controls (Mann-Whitney U test). PMID:11409830

  7. A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy.

    PubMed

    Kossoff, Eric H; Los, Jenna G; Boatman, Dana F

    2007-12-01

    Benign rolandic epilepsy (BRE) and Landau-Kleffner syndrome (LKS) are similar epilepsy syndromes with sleep-accentuated epileptiform activity, sporadic seizures, and language dysfunction. Levetiracetam has been associated with improved language function in LKS and seizure reduction in BRE. We hypothesized levetiracetam would improve language function in children with BRE. A pilot study was performed with six children (aged 6-12) with BRE and evidence of impaired auditory comprehension and verbal memory. Children were transitioned from their current anticonvulsant to 40 mg/kg/day levetiracetam over a 2-week period and retested at 6 months. At 6 months, three of four children with baseline auditory comprehension impairments performed normally (P=0.06), and five had improved auditory verbal memory (P=0.08). Seizures improved in five, decreasing from 2.7 to 1.0 seizure per 6 months (P=0.11). Results from this pilot study suggest that levetiracetam may have a beneficial effect on language in children with BRE.

  8. Orbital and Subcutaneous Emphysema Following Enucleation and Respiratory Distress in a Japanese Chin.

    PubMed

    Gornik, Kara R; Pirie, Christopher G; Alario, Anthony F

    2015-01-01

    A 7 yr old, neutered male Japanese chin presented to the Cummings School of Veterinary Medicine at Tufts University (CSVMTU) for evaluation of chronic unilateral orbital swelling that worsened following an episode of respiratory distress. The left eye had been enucleated 5 yr previously. Intermittent mild-to-moderate left orbital swelling had been noted by the owner since the initial surgery. Examination demonstrated a moderate-to-severe, soft, fluctuant swelling involving the left orbit with erythema of the overlying skin. Crepitus was noted over the occipital tuberosity. Computed tomography revealed a large volume of gas involving the left orbit. The gas extended caudally within the subcutaneous tissues to both hemimandibles, dorsal to the cranium, and partially surrounded the cranial neck. The presence of a mucosa-lined, air-filled space with a patent nasolacrimal duct was noted on orbital exploration. The lining was removed and the duct closed. Histopathology confirmed the presence of an epithelial lining. No recurrence of the swelling was observed on examination 8 wk after surgery. This is the first report documenting acute worsening of orbital swelling following an episode of respiratory distress. This case highlights the importance of addressing the nasolacrimal duct while performing an enculeation in a brachycephalic dog. PMID:26535462

  9. Short and long-latency responses in human masseter muscle evoked by chin taps.

    PubMed

    Hellsing, G; Klineberg, I

    1984-01-01

    Ten healthy subjects received downward, backward and upward chin taps with standardized force and direction. Taps in all three directions elicited short (M1) and long (M2 and M3)-latency excitatory EMG responses in the masseter muscle. M1 (mean latency 8.9 ms, amplitude 150 microV) occurred more frequently and with shorter latency during clenching than during relaxation or opening. Downward taps were more efficient in evoking jaw-jerks (25 per cent) than upward (14 per cent) and backward ones (16 per cent). M2 was a weak biphasic deflection occurring during the silent period (mean latency 42 ms, amplitude 87 microV) and M3 was an EMG burst following the silent period (mean latency 69.3 ms, amplitude 169 microV). No long-latency evoked responses were obtained from the relaxed masseter. Thus, muscle stretch increases M1 response frequency but is not a necessary prerequisite. The hypothesis that vibratory transmission plays an important role was confirmed. Voluntary activation of the stimulated muscle (clenching) increases M1-response frequency and shortens response latency.

  10. Cytodiagnosis of a Cutaneous Clear Cell Malignancy: Metastatic Renal Cell Carcinoma on Chin

    PubMed Central

    Mohan, Gyanendra; Chaturvedi, Sunanda; Khan, Shakir Ali

    2016-01-01

    Clear cell type of renal cell carcinoma (RCC) is most common urological malignancy. Several diagnostic challenges arise when it presents as a cutaneous nodule, being an uncommon presentation. Fine needle aspiration cytology (FNAC) of a cutaneous nodule is crucial for distinguishing primary tumours from metastatic tumours because cutaneous metastases represent a terminal stage of illness. Due to considerable overlap of cytomorphological features determination of primary warrants need of detailed clinical history and close inspection of every cytological detail. We report here a case of cutaneous metastasis of RCC on chin in a patient 11 years after nephrectomy. Though there are reports of RCC metastases diagnosed on histology, there are fewer cytology case reports. Cytological differential diagnosis has been discussed for arriving at the final diagnosis in case of clear cell tumours. Early and accurate diagnosis is mandatory for optimal treatment. Cytodiagnosis of cutaneous metastasis of RCC is uncommon due to its low suspicion index in cutaneous nodules. More so, it presents late and an unusual sites due to its resemblance to common dermatological diseases. PMID:26894079

  11. Orbital and Subcutaneous Emphysema Following Enucleation and Respiratory Distress in a Japanese Chin.

    PubMed

    Gornik, Kara R; Pirie, Christopher G; Alario, Anthony F

    2015-01-01

    A 7 yr old, neutered male Japanese chin presented to the Cummings School of Veterinary Medicine at Tufts University (CSVMTU) for evaluation of chronic unilateral orbital swelling that worsened following an episode of respiratory distress. The left eye had been enucleated 5 yr previously. Intermittent mild-to-moderate left orbital swelling had been noted by the owner since the initial surgery. Examination demonstrated a moderate-to-severe, soft, fluctuant swelling involving the left orbit with erythema of the overlying skin. Crepitus was noted over the occipital tuberosity. Computed tomography revealed a large volume of gas involving the left orbit. The gas extended caudally within the subcutaneous tissues to both hemimandibles, dorsal to the cranium, and partially surrounded the cranial neck. The presence of a mucosa-lined, air-filled space with a patent nasolacrimal duct was noted on orbital exploration. The lining was removed and the duct closed. Histopathology confirmed the presence of an epithelial lining. No recurrence of the swelling was observed on examination 8 wk after surgery. This is the first report documenting acute worsening of orbital swelling following an episode of respiratory distress. This case highlights the importance of addressing the nasolacrimal duct while performing an enculeation in a brachycephalic dog.

  12. Cone beam computed tomography in the differential diagnosis of mental neuropathy (numb chin syndrome) in metastatic colon cancer.

    PubMed

    Friedrich, Reinhard E; Heiland, Max; Assaf, Alexandre T; Riecke, Björn

    2013-04-01

    Neuropathy of the mental nerve, also referred to as numb chin syndrome (NCS), is a rare finding that demands for accurate differential diagnosis and therapy. This is a report of two patients with a history of colonic cancer, who experienced a progressive hypaesthesia of one side of the corner of the mouth, lower lip and chin, associated with intermittent phases of pain some weeks prior to admission to hospital. Orthopantomograms were insufficient to disclose the relationship between the osseous lesion and the nerve canal. Cone beam computed tomography (CBCT) clearly disclosed the widely spreading, in-growing tumour of the mandible and the affection of the canal's boundary. CBCT is recommended as the imaging modality of primary choice to disclose apparent osseous affections of the mandibular canal and foramina associated with NCS, in particular in the diagnostics of outpatients admitted to specialized clinics and in the dental office.

  13. To fix or not to fix: the role of 2-phenoxyethanol in rabbit, Oryctolagus cuniculus, chin gland secretion.

    PubMed

    Hayes, R A; Richardson, B J; Wyllie, S G

    2003-05-01

    The European rabbit (Oryctolagus cuniculus) uses the secretion of the chin gland to maintain dominance hierarchies in the wild. Recent work has investigated changes in the secretion when social status is manipulated in the rabbit. When a rabbit becomes dominant, a new compound appears in his secretion, 2-phenoxyethanol. This compound is used as a fixative in the perfume industry. This study investigates whether the compound performs a similar function in the secretion of the rabbit. 2-Phenoxyethanol is not detected olfactorially by rabbits, and slows the release rate of some of the compounds that occur naturally in rabbit chin gland secretion. We suggest that when a rabbit becomes dominant, he adds a fixative to his secretion so that his scent will persist in the environment and not dissipate. He will thus come to dominate the olfactory environment, in much the same way as he does the physical environment.

  14. Persistent infection of the chin with an unusual skin pathogen (Streptococcus milleri): a sign of intraoral carcinoma.

    PubMed

    Buckley, D A; Murphy, A; Dervan, P; Hone, R; O'Dwyer, T; O'Loughlin, S

    1998-01-01

    Streptococcus milleri is a commensal of the oropharynx and gastrointestinal tract which is not generally associated with skin disease. We now report a patient who presented with a pustular mass of the chin with lower lip anaesthesia. He was initially thought to have sycosis barbae, but response to treatment was poor and lesional swabs repeatedly cultured S. milleri. After some delay, squamous cell carcinoma of the mouth, involving the mandible and overlying skin, was detected. We consider that the S. milleri either invaded through the tumour from the mouth or root canal or colonized the skin from saliva dribbled over the numb lower lip. Isolation of an unusual organism and numbness of the chin are features that should suggest the need for early radiography. PMID:9667108

  15. Health and Human Rights in Chin State, Western Burma: A Population-Based Assessment Using Multistaged Household Cluster Sampling

    PubMed Central

    Sollom, Richard; Richards, Adam K.; Parmar, Parveen; Mullany, Luke C.; Lian, Salai Bawi; Iacopino, Vincent; Beyrer, Chris

    2011-01-01

    Background The Chin State of Burma (also known as Myanmar) is an isolated ethnic minority area with poor health outcomes and reports of food insecurity and human rights violations. We report on a population-based assessment of health and human rights in Chin State. We sought to quantify reported human rights violations in Chin State and associations between these reported violations and health status at the household level. Methods and Findings Multistaged household cluster sampling was done. Heads of household were interviewed on demographics, access to health care, health status, food insecurity, forced displacement, forced labor, and other human rights violations during the preceding 12 months. Ratios of the prevalence of household hunger comparing exposed and unexposed to each reported violation were estimated using binomial regression, and 95% confidence intervals (CIs) were constructed. Multivariate models were done to adjust for possible confounders. Overall, 91.9% of households (95% CI 89.7%–94.1%) reported forced labor in the past 12 months. Forty-three percent of households met FANTA-2 (Food and Nutrition Technical Assistance II project) definitions for moderate to severe household hunger. Common violations reported were food theft, livestock theft or killing, forced displacement, beatings and torture, detentions, disappearances, and religious and ethnic persecution. Self reporting of multiple rights abuses was independently associated with household hunger. Conclusions Our findings indicate widespread self-reports of human rights violations. The nature and extent of these violations may warrant investigation by the United Nations or International Criminal Court. Please see later in the article for the Editors' Summary PMID:21346799

  16. Availability of ground water on Federal land near the Ak-Chin Indian Reservation, Arizona: a reconnaissance study

    USGS Publications Warehouse

    Wilson, Richard P.

    1979-01-01

    Sufficient ground water to provide about 2.1 million acre-feet in a 25-year period is available for delivery to the Ak-Chin Indian Reservation from Federal land in the Vekol Valley, Waterman Wash area, and Bosque area in south-central Arizona. Withdrawal of 85,000 acre-feet per year as required by the Ak-Chin water-supply act--Public Law 95-328--will greatly deplete the amount of water in storage and may cause land subsidence in the areas. Study concurrent with well-field development will enable design changes to minimize pumping costs , water-level declines, movement of poor-quality water into the well fields, and potential land subsidence and associated earth fissures. Surface and bore-hole geophysical testing, aquifer tests, and the development of simulative mathematical models will accomplish these goals and permit quantitative evaluations of the potential deleterious effects resulting from development of the water supply. (Woodard-USGS)

  17. Chin tuck against resistance (CTAR): new method for enhancing suprahyoid muscle activity using a Shaker-type exercise.

    PubMed

    Yoon, Wai Lam; Khoo, Jason Kai Peng; Rickard Liow, Susan J

    2014-04-01

    For patients with dysphagia resulting from upper esophageal sphincter dysfunction, strengthening the suprahyoid muscles through therapeutic exercise has proved effective in restoring oral feeding. The aim of this study was to compare the maximum and mean surface electromyography (sEMG) activity of the suprahyoid muscles during the Chin Tuck Against Resistance (CTAR) exercise and the Shaker exercise for both isokinetic and isometric tasks. During the CTAR exercises, the participant is seated while tucking the chin to compress an inflatable rubber ball, whereas during the Shaker exercise, the participant is lay supine while lifting the head to look at the feet. Forty healthy participants (20 males, 20 females) aged 21-39 years completed all four tasks in counterbalanced order, with measures of resting activation taken prior to each exercise. Although subjective feedback suggested that the sitting position for CTAR is less strenuous than the supine position for Shaker, the results of separate analyses showed significantly greater maximum sEMG values during the CTAR isokinetic and isometric exercises than during the equivalent Shaker exercises, and significantly greater mean sEMG values were observed for the CTAR isometric exercise than for the Shaker isometric exercise. Clinical trials are now needed, but the CTAR exercises appear effective in exercising the suprahyoid muscles, and they could achieve therapeutic effects comparable to those of Shaker exercises, with the potential for greater compliance by patients.

  18. Bimaxillary protrusion with an atrophic alveolar defect: orthodontics, autogenous chin-block graft, soft tissue augmentation, and an implant.

    PubMed

    Chiu, Grace S C; Chang, Chris H N; Roberts, W Eugene

    2015-01-01

    Bimaxillary protrusion in a 28-year-old woman was complicated by multiple missing, restoratively compromised, or hopeless teeth. The maxillary right central incisor had a history of avulsion and replantation that subsequently evolved into generalized external root resorption with Class III mobility and severe loss of the supporting periodontium. This complex malocclusion had a discrepancy index of 21, and 8 additional points were scored for the atrophic dental implant site (maxillary right central incisor). The comprehensive treatment plan included extraction of 4 teeth (both maxillary first premolars, the maxillary right central incisor, and the mandibular right first molar), orthodontic closure of all spaces except for the future implant site (maxillary right central incisor), augmentation of the alveolar defect with an autogenous chin-block graft, enhancement of the gingival biotype with a connective tissue graft, and an implant-supported prosthesis. Orthodontists must understand the limitations of bone grafts. Augmented alveolar defects are slow to completely turn over to living bone, so they are usually good sites for implants but respond poorly to orthodontic space closure. However, postsurgical orthodontic treatment is often indicated to optimally finish the esthetic zone before placing the final prosthesis. The latter was effectively performed for this patient, resulting in a total treatment time of about 36 months for comprehensive interdisciplinary care. An excellent functional and esthetic result was achieved. PMID:25533077

  19. Size and placement of developing anterior teeth in immature Neanderthal mandibles from Dederiyeh Cave, Syria: implications for emergence of the modern human chin.

    PubMed

    Fukase, Hitoshi; Kondo, Osamu; Ishida, Hajime

    2015-03-01

    Evolutionary and functional significance of the human chin has long been explored from various perspectives including masticatory biomechanics, speech, and anterior tooth size. Recent ontogenetic studies have indicated that the spatial position of internally forming anterior teeth partially constrains adult mandibular symphyseal morphology. The present study therefore preliminarily examined the size and placement of developing anterior teeth in immature Neanderthal mandibles of Dederiyeh 1 and 2, compared with similarly-aged modern humans (N = 16) and chimpanzees (N = 7) whose incisors are comparatively small and large among extant hominids, respectively. The Dederiyeh 1 mandible is described as slightly presenting a mental trigone and attendant mental fossa, whereas Dederiyeh 2 completely lacks such chin-associated configurations. Results showed that, despite symphyseal size being within the modern human range, both Dederiyeh mandibles accommodated overall larger anterior dentition and displayed a remarkably wide bicanine space compared to those of modern humans. Dederiyeh 2 had comparatively thicker deciduous incisor roots and more enlarged permanent incisor crypts than Dederiyeh 1, but both Dederiyeh individuals exhibited a total dental size mostly intermediate between modern humans and chimpanzees. These findings potentially imply that the large deciduous/permanent incisors collectively distended the labial alveolar bone, obscuring an incipient mental trigone. It is therefore hypothesized that the appearance of chin-associated features, particularly of the mental trigone and fossa, can be accounted for partly by developmental relationships between the sizes of the available mandibular space and anterior teeth. This hypothesis must be, however, further addressed with more referential samples in future studies.

  20. Growth data of underprivileged children living in rural areas of Chin State, Burma/Myanmar, compared to the WHO reference growth standards: an observational study

    PubMed Central

    Prenkert, Malin; Ehnfors, Margareta

    2016-01-01

    Objectives To explore growth data (height-for-age, weight-for-age and BMI-for-age) of children living in poor socioeconomic conditions in rural areas of Chin State, Burma/Myanmar; and to compare these data with the growth and development z-score (GDZ) values for school-aged children and adolescents, provided by the WHO. Setting A support and educational programme, run by the Swedish association Chin Development and Research Society (CDRS), was carried out among underprivileged school-aged children, unable to attend school without economic and practical support, living in villages and remote areas in Chin State. Participants Community leaders who were well familiar with the citizens in the community identified children in need of this support. Other community members could also suggest or apply for this. The sample includes all participating children in the CDRS programme at the time of the data collection in six townships. The children were placed in host families, close to a suitable school. Two samples with a total of 639 children from 144 villages and remote areas were obtained: 1. Children in the CDRS Chin Programme (CCP) (2007–2010) comprised 558 children: 50% girls and boys. 2. Children in the Chin Society (CCS) (2010) comprised 81 children: 44% girls and 56% boys. Primary outcome measures Growth data. Results All growth data from both groups deviated significantly from the WHO standard references (p≤0.001). The prevalence of stunting (height-for-age ≤–2SD) was 52% among girls and 68% among boys. High levels of wasting (weight-for-age ≤–2SD) were found among girls 29% and boys 36% aged 5–10 years. In addition, severe thinness (BMI-for-age ≤–2SD) was found among girls 31% and boys 44%, all results to be compared to the expected 2.27%. Conclusions Many more than expected—according to the WHO reference values—in CCP and CCS suffered from stunting, wasting and thinness. PMID:26787249

  1. Comparative Analysis of Reproductive Traits in Black-Chinned Tilapia Females from Various Coastal Marine, Estuarine and Freshwater Ecosystems

    PubMed Central

    Kantoussan, Justin; Ndiaye, Papa; Thiaw, Omar Thiom; Albaret, Jean-Jacques

    2012-01-01

    The black-chinned tilapia Sarotherodon melanotheron is a marine teleost characterised by an extreme euryhalinity. However, beyond a certain threshold at very high salinity, the species exhibits impaired growth and precocious reproduction. In this study, the relationships between reproductive parameters, environmental salinity and condition factor were investigated in wild populations of this species that were sampled in two consecutive years (2003 and 2004) from three locations in Senegal with different salinities: Guiers lake (freshwater, 0 psu), Hann bay (seawater, 37 psu) and Saloum estuary (hypersaline water, 66–127 psu). The highest absolute fecundity and spawning weight were recorded in seawater by comparison to either freshwater or hypersaline water whereas the poorest condition factors were observed in the most saline sampling site. These results reflect higher resource allocation to the reproduction due to the lowest costs of adaptation to salinity in seawater (the natural environment of this species) rather than differences in food resources at sites and/or efficiency at foraging and prey availability. Fecundities, oocyte size as well as spawning weight were consistent from year to year. However, the relative fecundity in the Saloum estuary varied significantly between the dry and rainy raisons with higher values in the wet season, which seems to reflect seasonal variations in environmental salinity. Such a reproductive tactic of producing large amounts of eggs in the rainy season when the salinity in the estuary was lower, would give the fry a better chance at survival and therefore assures a high larval recruitment. An inverse correlation was found between relative fecundity and oocyte size at the two extreme salinity locations, indicating that S. melanotheron has different reproductive strategies in these ecosystems. The adaptive significance of these two reproductive modes is discussed in regard to the heavy osmotic constraint imposed by extreme

  2. Tribute to Christine Chin

    ERIC Educational Resources Information Center

    Teo, Tang Wee; Tan, Aik-Ling

    2015-01-01

    It has been more than 3 years since Christine left us. She has left a lasting legacy of her academic brilliance among the science education community. This paper pays tribute to Christine's fine research work that has shaped and continues to shape science education research in the field of questioning and argumentation.

  3. Mystery behind Non-Healing Wound at Chin Region - Myiasis due to Neglected Trauma – A Case Report with Review of Literature

    PubMed Central

    Hajira, Neha

    2016-01-01

    Myiasis is the infestation of human beings with fly larvae which feed on host’s living or dead tissue. Diagnosis of this condition is made by the presence of larvae in affected body parts. The standard treatment is the mechanical removal of the maggots from the lesion and management of the general systemic condition. This paper report a case of myiasis at the chin region in a 45-year-old male managed by manual removal of larvae after topical application of turpentine oil, surgical debridement of necrotic tissues and antimicrobial therapy. PMID:27504426

  4. Mystery behind Non-Healing Wound at Chin Region - Myiasis due to Neglected Trauma - A Case Report with Review of Literature.

    PubMed

    Khandelwal, Pulkit; Hajira, Neha

    2016-06-01

    Myiasis is the infestation of human beings with fly larvae which feed on host's living or dead tissue. Diagnosis of this condition is made by the presence of larvae in affected body parts. The standard treatment is the mechanical removal of the maggots from the lesion and management of the general systemic condition. This paper report a case of myiasis at the chin region in a 45-year-old male managed by manual removal of larvae after topical application of turpentine oil, surgical debridement of necrotic tissues and antimicrobial therapy. PMID:27504426

  5. Evaluating the Training Effects of Two Swallowing Rehabilitation Therapies Using Surface Electromyography--Chin Tuck Against Resistance (CTAR) Exercise and the Shaker Exercise.

    PubMed

    Sze, Wei Ping; Yoon, Wai Lam; Escoffier, Nicolas; Rickard Liow, Susan J

    2016-04-01

    In this study, the efficacy of two dysphagia interventions, the Chin Tuck against Resistance (CTAR) and Shaker exercises, were evaluated based on two principles in exercise science-muscle-specificity and training intensity. Both exercises were developed to strengthen the suprahyoid muscles, whose contractions facilitate the opening of the upper esophageal sphincter, thereby improving bolus transfer. Thirty-nine healthy adults performed two trials of both exercises in counter-balanced order. Surface electromyography (sEMG) recordings were simultaneously collected from suprahyoid muscle group and sternocleidomastoid muscle during the exercises. Converging results using sEMG amplitude analyses suggested that the CTAR was more specific in targeting the suprahyoid muscles than the Shaker exercise. Fatigue analyses on sEMG signals further indicated that the suprahyoid muscle group were equally or significantly fatigued (depending on metric), when participants carried out CTAR compared to the Shaker exercise. Importantly, unlike during Shaker exercise, the sternocleidomastoid muscles were significantly less activated and fatigued during CTAR. Lowering the chin against resistance is therefore sufficiently specific and intense to fatigue the suprahyoid muscles.

  6. Polybrominated diphenyl ethers in fat samples from White-chinned Petrels (Procellaria aequinoctialis) and Spectacled Petrels (P. conspicillata) off southern Brazil.

    PubMed

    Cipro, Caio V Z; Colabuono, Fernanda I; Taniguchi, Satie; Montone, Rosalinda C

    2013-12-15

    Polybrominated diphenyl ethers (PBDEs) have been gaining much visibility in environmental chemical studies due to their similarity to PCBs and growing reports of harmful effects. The fact that these contaminants have not yet undergone bans or restrictions on the global level underscores the need for data on their occurrence. In the present study, fat samples from 26 White-chinned Petrels (Procellaria aequinoctialis) and 3 Spectacled Petrels (P. conspicillata) collected dead ashore or as bycatch of longline fisheries in southern Brazil were analyzed to determine concentrations of seven congeners (IUPAC #28, 47, 99, 100, 153, 154 and 183). Concentrations of ΣPBDEs ranged from not detectable to 72.70 ng g(-1) (wet weight), comparatively lower than concentrations reported for seabird samples in northern hemisphere. The most detected congeners were 153, 154 and 183. This pattern is close to that previously reported for birds of the same group, but not those from the same region. PMID:24143957

  7. Plasticity of gene expression according to salinity in the testis of broodstock and F1 black-chinned tilapia, Sarotherodon melanotheron heudelotii

    PubMed Central

    Guinand, Bruno; Dugué, Rémi; Cosson, Jacky; Legendre, Marc; Panfili, Jacques; Durand, Jean-Dominique

    2014-01-01

    The black-chinned tilapia Sarotherodon melanotheron heudelotii Rüppell 1852 (Teleostei, Cichlidae) displays remarkable acclimation capacities. When exposed to drastic changes of salinity, which can be the case in its natural habitat, it develops quick physiological responses and keeps reproducing. The present study focused on the physiological impact of salinity on male reproductive capacities, using gene expression as a proxy of acclimation process. Two series of experimental fish were investigated: the first one was composed of fish maintained in freshwater for several generations and newly acclimated to salinities of 35 and 70, whereas the second one consisted of the descendants of the latter born and were raised under their native salinity. Expression patterns of 43 candidate genes previously identified from the testes of wild males was investigated in the three salinities and two generations. Twenty of them showed significant expression differences between salinities, and their predicted function revealed that most of them are involved in the osmotic tolerance of sperm cells and/or in the maintenance of sperm motility. A high level of expression variation was evidenced, especially for fish maintained in freshwater. In spite of this, gene expression patterns allowed the differentiation between fish raised in freshwater and those maintained in hypersaline water in both generations. Altogether, the results presented here suggest that this high variability of expression is likely to ensure the reproductive success of this species under varying salinities. PMID:25548735

  8. PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.

    PubMed

    Beatty, Alexander; Morton, Diane G; Kemphues, Kenneth

    2013-05-01

    In the one-cell C. elegans embryo, polarity is maintained by mutual antagonism between the anterior cortical proteins PAR-3, PKC-3, PAR-6 and CDC-42, and the posterior cortical proteins PAR-2 and LGL-1 on the posterior cortex. The mechanisms by which these proteins interact to maintain polarity are incompletely understood. In this study, we investigate the interplay among PAR-2, LGL-1, myosin, the anterior PAR proteins and CDC-42. We find that PAR-2 and LGL-1 affect cortical myosin accumulation by different mechanisms. LGL-1 does not directly antagonize the accumulation of cortical myosin and instead plays a role in regulating PAR-6 levels. By contrast, PAR-2 likely has separate roles in regulating cortical myosin accumulation and preventing the expansion of the anterior cortical domain. We also provide evidence that asymmetry of active CDC-42 can be maintained independently of LGL-1 and PAR-2 by a redundant pathway that includes the CDC-42 GAP CHIN-1. Finally, we show that, in addition to its primary role in regulating the size of the anterior cortical domain via its binding to PAR-6, CDC-42 has a secondary role in regulating cortical myosin that is not dependent on PAR-6.

  9. Osmoregulatory strategies in natural populations of the black-chinned tilapia Sarotherodon melanotheron exposed to extreme salinities in West African estuaries.

    PubMed

    Lorin-Nebel, Catherine; Avarre, Jean-Christophe; Faivre, Nicolas; Wallon, Sophie; Charmantier, Guy; Durand, Jean-Dominique

    2012-08-01

    The effect of salinity was studied in natural populations of the black-chinned tilapia (Sarotherodon melanotheron) from West Africa. This euryhaline species colonizes nearly all coastal environments from bays to lagoons characterized by salinities ranging from fresh water to hypersaline water over 100 ‰. Individuals were sampled during the dry season at several locations characterized by different levels of salinity (3-102 ‰). Their osmotic status and their gills were analyzed. The branchial mitochondria-rich cells (MRC), localized at the basis of the filaments and along the lamellae in fish taken from the saline stations, showed a wide plasticity with significant differences in their number and size. The most striking results were a significant larger area (≈3x) and a higher number (≈55x) of MRC at high salinity (102 ‰) compared to low salinity (3 ‰). The major ion transporters and channels were localized by immunocytochemistry and different expression patterns have been recorded between stations. Despite an increased Na⁺/K⁺-ATPase (NKA) α-subunit expression and NKA activity, pointing to an increased monovalent ion excretion, a severe osmotic imbalance was recorded in animals living in hypersaline environments.

  10. Seasonal accumulations of some heavy metal in water, sediment and tissues of black-chinned tilapia Sarotherodon melanotheron from Biétri Bay in Ebrié Lagoon, Ivory Coast.

    PubMed

    Coulibaly, Safiatou; Atse, Boua Célestin; Koffi, Kouamé Mathias; Sylla, Soumaïla; Konan, Kouadio Justin; Kouassi, N'Guessan Joël

    2012-04-01

    The seasonal accumulation of cadmium, copper, lead, mercury and zinc was determined in sediments, water, and black-chinned tilapia (Sarotherodon melanotheron; muscle, brain, kidney and liver tissues) collected monthly from Biétri Bay. The mean water concentration of metals (in mg L(-1)) ranged from 0.01 to 0.30 (mercury), 0.02-0.26 (cadmium), 2.40-4.80 (lead), 9.05-9.68 (copper), and 12.05-19.87 (zinc). The seasonal variations showed a significant difference in the levels of mercury, cadmium and lead among season. The highest mercury (0.30 ± 0.02 μg L(-1)), cadmium (0.26 ± 0.02 mg L(-1)) and lead (4.80 ± 1.03 mg L(-1)) levels were observed during dry season, while the lowest levels (0.21 ± 0.01, 0.02 ± 0.01 and 2.40 ± 0.02 mg L(-1), respectively mercury, cadmium and lead) were measured during rainy season. The average cadmium (0.58 ± 0.36 mg L(-1)), copper (42.15 ± 19.40 mg L(-1)), lead (58.47 ± 38.10 mg kg(-1)), mercury (0.79 ± 0.47 μg kg(-1)) and zinc (187.58 ± 76.99 mg kg(-1)) concentrations determined in Biétri Bay sediments showed a similar trend as in water. The seasonal variations of mercury, cadmium and lead in tissues revealed that these metals were higher concentrated during dry and swelling seasons. The levels of zinc and copper followed by lead were higher in the tissues. The order of tissues metals concentrations was: kidney > liver > brain > muscle.

  11. Identification of Reliable Sulcal Patterns of the Human Rolandic Region.

    PubMed

    Mellerio, Charles; Lapointe, Marie-Noël; Roca, Pauline; Charron, Sylvain; Legrand, Laurence; Meder, Jean-François; Oppenheim, Catherine; Cachia, Arnaud

    2016-01-01

    A major feature of the human cortex is its huge morphological variability. Although a comprehensive literature about the sulco-gyral pattern of the central region is available from post-mortem data, a reliable and reproducible characterization from in vivo data is still lacking. The aim of this study is to test the reliability of morphological criteria of the central region sulci used in post-mortem data, when applied to in vivo magnetic resonance imaging (MRI) data. Thirty right-handed healthy individuals were included in the study. Automated segmentation and three dimensional (3D) surface-based rendering were obtained from clinical 3D T1-weighted MRI. Two senior radiologists labeled the three sulci composing the central region (precentral [PreCS], central [CS] and postcentral [PostCS]) and analyzed their morphological variations using 47 standard criteria derived from Ono's atlas based on post-mortem data. For each criterion, inter-rater concordance and comparison with the occurrence frequency provided in Ono's atlas were estimated. Overall, the sulcal pattern criteria derived from MRI data were highly reproducible between the raters with a high mean inter-rater concordance in the three sulci (CS: κ = 0.92 in left hemisphere/κ = 0.91 in right hemisphere; PreCS: κ = 0.91/κ = 0.93; PostCS: κ = 0.84/0.79). Only a very limited number of sulcal criteria significantly differed between the in vivo and the post-mortem data (CS: 2 criteria in the left hemisphere/3 criteria in the right hemisphere; PreCS: 3 in the left and right hemispheres; PostCS: 3 in the left hemisphere and 5 in the right hemisphere). Our study provides a comprehensive description of qualitative sulcal patterns in the central region from in vivo clinical MRI with high agreement with previous post-mortem data. Such identification of reliable sulcal patterns of the central region visible with standard clinical MRI data paves the way for the detection of subtle variations of the central sulcation associated with variations of normal or pathological functioning. PMID:27582700

  12. [The atypical developments of rolandic epilepsy are predictable complications].

    PubMed

    Pesántez-Ríos, Gabriela; Martínez-Bermejo, Antonio; Arcas, Joaquín; Merino-Andreu, Milagros; Ugalde-Canitrot, Arturo

    2015-08-01

    Introduccion. Las evoluciones atipicas de la epilepsia rolandica son parte de un espectro clinico de fenotipos variables, idiopaticos, dependientes de la edad y con una predisposicion geneticamente determinada. Objetivo. Estudiar las caracteristicas electroclinicas sugestivas de una evolucion atipica en la epilepsia rolandica. Pacientes y metodos. Se realizo una busqueda retrospectiva de 133 niños diagnosticados de epilepsia focal benigna atipica (EFBA), sindrome de Landau-Kleffner y epilepsia de punta-onda continua durante el sueño (POCS). Se seleccionaron nueve pacientes que, en el trascurso de su epilepsia rolandica, presentaron un cuadro clinico atipico y un patron electroencefalografico (EEG) de estado epileptico electrico durante el sueño (ESES). Resultados. El inicio de la epilepsia rolandica fue, en promedio, a los 5 años. Los pacientes presentaron un empeoramiento clinico y del EEG año y medio mas tarde en promedio. En tres pacientes se observaron caracteristicas de EFBA, y en seis, de POCS. No se encontraron casos de sindrome de Landau-Kleffner. El EEG en vigilia mostro una focalidad centrotemporal izquierda en seis pacientes, y derecha, en tres. Todos los pacientes presentaron un ESES en el EEG de sueño. En tres de ellos se observo un patron atipico de ESES regional. Ademas, se detectaron alteraciones cognitivas y conductuales por deficits en areas especificas del aprendizaje, como lenguaje, memoria, atencion e inquietud. Conclusiones. El inicio precoz de la epilepsia rolandica, la aparicion de nuevas crisis con un incremento en su frecuencia y una focalidad frontocentrotemporal en el EEG, que aumenta en frecuencia, tanto en vigilia como en sueño, son caracteristicas electroclinicas sugerentes de una evolucion atipica.

  13. Identification of Reliable Sulcal Patterns of the Human Rolandic Region

    PubMed Central

    Mellerio, Charles; Lapointe, Marie-Noël; Roca, Pauline; Charron, Sylvain; Legrand, Laurence; Meder, Jean-François; Oppenheim, Catherine; Cachia, Arnaud

    2016-01-01

    A major feature of the human cortex is its huge morphological variability. Although a comprehensive literature about the sulco-gyral pattern of the central region is available from post-mortem data, a reliable and reproducible characterization from in vivo data is still lacking. The aim of this study is to test the reliability of morphological criteria of the central region sulci used in post-mortem data, when applied to in vivo magnetic resonance imaging (MRI) data. Thirty right-handed healthy individuals were included in the study. Automated segmentation and three dimensional (3D) surface-based rendering were obtained from clinical 3D T1-weighted MRI. Two senior radiologists labeled the three sulci composing the central region (precentral [PreCS], central [CS] and postcentral [PostCS]) and analyzed their morphological variations using 47 standard criteria derived from Ono’s atlas based on post-mortem data. For each criterion, inter-rater concordance and comparison with the occurrence frequency provided in Ono’s atlas were estimated. Overall, the sulcal pattern criteria derived from MRI data were highly reproducible between the raters with a high mean inter-rater concordance in the three sulci (CS: κ = 0.92 in left hemisphere/κ = 0.91 in right hemisphere; PreCS: κ = 0.91/κ = 0.93; PostCS: κ = 0.84/0.79). Only a very limited number of sulcal criteria significantly differed between the in vivo and the post-mortem data (CS: 2 criteria in the left hemisphere/3 criteria in the right hemisphere; PreCS: 3 in the left and right hemispheres; PostCS: 3 in the left hemisphere and 5 in the right hemisphere). Our study provides a comprehensive description of qualitative sulcal patterns in the central region from in vivo clinical MRI with high agreement with previous post-mortem data. Such identification of reliable sulcal patterns of the central region visible with standard clinical MRI data paves the way for the detection of subtle variations of the central sulcation associated with variations of normal or pathological functioning. PMID:27582700

  14. The Roland Maze Project — Cosmic Ray Registration at Schools

    NASA Astrophysics Data System (ADS)

    Feder, J.; JȨDRZEJCZAK, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Tokarski, P.; Wibig, T.

    Experimental studies of cosmic rays at the highest energies (above 1018 eV) are the main scientific goal of the projected large area network of extensive air shower detectors. Placing the detectors on the roofs of high school buildings will lower the cost by using the existing urban infrastructure (INTERNET, power supply, etc.), and can be a very efficient way of science popularisation by engaging high school students in the research program. 30 high schools in Łódź are already involved in the project. The project has recently obtained some financial support from the City Council of Łódź. The donation enabled us to start experimental work on detector construction details. A cycle of lectures and seminars devoted to different aspects of project realization (detector construction, on-line data acquisition system, C++ programming) has been organized for students at our Institute and at schools.

  15. [Neuropsychological alterations are frequent in rolandic epilepsy and its atypical developments].

    PubMed

    Pesantez-Rios, G; Martinez-Bermejo, A; Pesantez-Cuesta, G

    2016-08-01

    Introduccion. La epilepsia rolandica o epilepsia benigna de la infancia con puntas centrotemporales se denomina benigna debido a lo favorables que suelen ser sus crisis y a la espontanea normalizacion del electroencefalograma al llegar a la pubertad, aunque se ha demostrado el impacto sobre el desarrollo cognitivo con la presencia de deficits cognitivos heterogeneos, relacionados especialmente con las descargas intercriticas persistentes durante el sueño no REM. El objetivo de este trabajo es estudiar las redes epileptogenas involucradas en los trastornos neuropsicologicos de esta patologia. Desarrollo. Las evoluciones atipicas tienen en comun una actividad epileptica persistente durante el sueño lento, que desempeña un papel importante en el desarrollo de los deficits neurocognitivos que se asocian a esta patologia. Factores como la edad de inicio de la epilepsia, el inicio de la evolucion atipica, la localizacion de las descargas interictales y la actividad epileptica continua durante el sueño que persista durante mas de dos años pueden provocar cambios en el funcionamiento de las redes neurocognitivas, con los consecuentes deficits en las funciones neuropsicologicas, que incluso pueden resultar irreversibles. Conclusiones. Es necesario un seguimiento cercano tanto clinico como electroencefalografico; ademas, deben realizarse estudios neuropsicologicos formales desde el inicio de la epilepsia benigna de la infancia con puntas centrotemporales y mas en los casos que es evidente una evolucion atipica para detectar y prevenir los deficits neuropsicologicos antes de que se instauren definitivamente.

  16. The Roland Maze Project school-based extensive air shower network

    NASA Astrophysics Data System (ADS)

    Feder, J.; Jȩdrzejczak, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Wibig, T.

    2006-01-01

    We plan to construct the large area network of extensive air shower detectors placed on the roofs of high school buildings in the city of Łódź. Detection points will be connected by INTERNET to the central server and their work will be synchronized by GPS. The main scientific goal of the project are studies of ultra high energy cosmic rays. Using existing town infrastructure (INTERNET, power supply, etc.) will significantly reduce the cost of the experiment. Engaging high school students in the research program should significantly increase their knowledge of science and modern technologies, and can be a very efficient way of science popularisation. We performed simulations of the projected network capabilities of registering Extensive Air Showers and reconstructing energies of primary particles. Results of the simulations and the current status of project realisation will be presented.

  17. Chin Prompt Plus Re-Presentation as Treatment for Expulsion in Children with Feeding Disorders

    ERIC Educational Resources Information Center

    Wilkins, Jonathan W.; Piazza, Cathleen C.; Groff, Rebecca A.; Vaz, Petula C. M.

    2011-01-01

    Expulsion (spitting out food) is a problem behavior observed in many children with feeding disorders. In the current investigation, we identified 4 children diagnosed with a feeding disorder who exhibited high rates of expulsion. Treatment with re-presentation (placing expelled liquids or solids back into the child's mouth) was not effective in…

  18. Retrospective analysis of secondary alveolar cleft grafts using iliac of chin bone.

    PubMed

    Nwoku, Alagumba L; Al Atel, Abdullah; Al Shlash, Saud; Oluyadi, Bashir A; Ismail, Salwa

    2005-09-01

    The osseous closure of alveolar clefts is an integral component of a comprehensive rehabilitation of patients with cleft lip and palate and has assumed an essential position in the reconstruction of cleft deformity. Our study consists of 35 patients aged between 7 and 11 years who received secondary bone grafting of their cleft alveolus over a 30 month period from July 1999 to December 2003. There were 22 (62.9%) males and 13 (37.1%) females. In 25 cases, bone graft was harvested from the iliac crest and in 10 others, from the mandibular symphysis. A total number of 41 osteoplasties was performed in the 35 patients. Twenty osteoplasties maintained an alveolar height up to 75% and approximately that number showed resorption varying between 50% and 75%. There was no case of complete resorption of graft. There were no serious periodontal pockets found. In all cases, the wound healed well, and there was no complication. Our experience demonstrates that secondary alveolar bone grafting is an efficacious method of rehabilitating patients with alveolar clefts.

  19. "The Source of Learning Is Thought" Reading the "Chin-ssu lu" (???) with a "Western Eye"

    ERIC Educational Resources Information Center

    Reichenbach, Roland

    2016-01-01

    The contribution focuses on Neo-Confucian texts as collected by Zhu Xi (?? 1130-1200) and Lü Zuqian (1137-1181) and is a look from the "outside", from the perspective of German theories of Bildung ("self-cultivation"). It aims at demonstrating that among other insights that today's readers may gather from Neo-Confucian…

  20. Sleep-related, low voltage Rolandic and vertex spikes: an EEG marker of benignity in infancy-onset focal epilepsies.

    PubMed

    Bureau, Michelle; Cokar, Ozlem; Maton, Bruno; Genton, Pierre; Dravet, Charlotte

    2002-03-01

    Although benign forms of epilepsies with onset in infancy have recently been recognized, the occurrence of seizures in an infant or very young child is very often an event of great significance and the prognosis concerning both epilepsy and neuropsychological development must be guarded. No reliable clinical or electroencephalographic (EEG) markers that can predict the outcome have been described. In a retrospective series of 10 patients, we found a peculiar EEG pattern seen across sleep stages, but not in the waking state in infants whose first seizures appeared before the age of 1 year, and which were mostly complex focal. In all cases, follow-up showed a favourable outcome with complete seizure remission and no cognitive impairment. The specificity of these EEG changes was 100%, but the sensitivity was lower, since they were not seen in some of the infants with the same favourable outcome. We discuss the clinical similarities between our patients and those cases reported earlier by other authors as benign, non-familial or familial focal epilepsies, in whom, however, no interictal abnormalities had been seen on the EEG. Such EEG changes are probably specific to benign, self-limited, early onset focal epilepsies. PMID:11967175

  1. Holocene left-slip rate determined by cosmogenic surface dating on the Xidatan segment of the Kunlun Fault (Qinghai, Chin

    SciTech Connect

    Guoguang, Z; Caffee, M; Finkel, R; G,; demer, Y; Meriaux, A S; Qunlu,; Ryerson, F J; Tapponnier, P; Van der Woerd, J

    1998-09-01

    Cosmogenic dating, using in-situ 26A1 and 10Be in quartz pebbles from alluvial terrace surfaces, constrains the late Holocene slip rate on the Xidatan segment of the Kuniun fault in northeastern Tibet. Two terrace risers offset by 24 ± 3 and 33 f± 4m, having respective ages of 1788 ± 388 and 2914 ± 471 yr, imply a slip rate of 12.1 ± 2.6 mm/yr. The full range of ages obtained ((less than or equal to) 22.8 k.y., most of them between 6.7 and 1.4 k.y.) confirm that terrace deposition and incision, hence landform evolution, are modulated by post-glacial climate change. Coupled with minimum offsets of 9-12 m, this slip rate implies that great earthquakes (M-8) with a recurrence time of 800-1000 yr. rupture the Kunlun fault n

  2. Purely cutaneous Langerhans cell histiocytosis presenting as an ulcer on the chin in an elderly man successfully treated with thalidomide

    PubMed Central

    Subramaniyan, Radhakrishnan; Ramachandran, Rajagopal; Rajangam, Gnanasekaran; Donaparthi, Navya

    2015-01-01

    Langerhans cell histiocytosis (LCH) is a rare, clonal proliferative disorder of Langerhans’ cells of unknown etiology. Although the clinical presentation and therapeutic approach to the disease in children have been well established; limited data is available about the disease in adults. Purely cutaneous involvement of LCH in a man older than 70 years has rarely been described. Herein we report the case of a 71-year-old man with cutaneous LCH confined to the perioral region, scalp, and flexures successfully treated with thalidomide. PMID:26753141

  3. The Role of Selenium in HIV Infection Cosby A Stone, Kosuke Kawai, Roland Kupka, Wafaie W Fawzi Harvard School of Public Health

    PubMed Central

    Stone, Cosby A; Kawai, Kosuke; Kupka, Roland; Fawzi, Wafaie W.

    2010-01-01

    HIV infection is a global disease that disproportionately burdens populations with nutritional vulnerabilities. Laboratory experiments have shown that selenium has an inhibitory effect on HIV in vitro through antioxidant effects of glutathione peroxidase and other selenoproteins. Numerous studies have reported low selenium status in HIV-infected individuals, and serum selenium concentration declines with disease progression. Some cohort studies have shown an association between selenium deficiency and progression to AIDS or mortality. In several randomized controlled trials, selenium supplementation has reduced hospitalizations, diarrheal morbidity, and improved CD4 cell counts, but the evidence remains mixed. Additional trials are recommended to study the effect of selenium supplementation on opportunistic infections, and other HIV disease related comorbidities in the context of highly active antiretroviral therapy in both developing and developed countries. PMID:20961297

  4. Salinity-related variation in gene expression in wild populations of the black-chinned tilapia from various West African coastal marine, estuarine and freshwater habitats

    NASA Astrophysics Data System (ADS)

    Tine, Mbaye; McKenzie, David J.; Bonhomme, François; Durand, Jean-Dominique

    2011-01-01

    This study measured the relative expression of the genes coding for Na +, K +-ATPase 1α(NAKA), voltage-dependent anion channel (VDAC), cytochrome c oxidase-1 (COX), and NADH dehydrogenase (NDH), in gills of six wild populations of a West African tilapia species, acclimatised to a range of seasonal (rainy or dry) salinities in coastal, estuarine and freshwater sites. Previous laboratory experiments have demonstrated that these genes, involved in active ion transport, oxidative phosphorylation, and intra-cellular ATP transport, are relatively over-expressed in gill tissues of this species acclimated to high salinity. Positive correlations between relative expression and ambient salinity were found for all genes in the wild populations (Spearman rank correlation, p < 0.05), although for some genes these were only significant in either the rainy season or dry season. Most significantly, however, relative expression was positively correlated amongst the four genes, indicating that they are functionally interrelated in adaptation of Sarotherodon melanotheron to salinity variations in its natural environment. In the rainy season, when salinity was unstable and ranged between zero and 37 psu across the sites, overall mean expression of the genes was higher than in the dry season, which may have reflected more variable particularly sudden fluctuations in salinity and poorer overall water quality. In the dry season, when the salinity is more stable but ranged between zero and 100 psu across the sites, NAKA, NDH and VDAC expression revealed U-shaped relationships with lowest relative expression at salinities approaching seawater, between 25 and 45 psu. Although it is not simple to establish direct relationship between gene expression levels and energy requirement for osmoregulation, these results may indicate that costs of adaptation to salinity are lowest in seawater, the natural environment of this species. While S. melanotheron can colonise environments with extremely high salinities, up to 100 psu, this was related to high relative expression for all genes studied, indicating that this imposes increased energy demand for osmotic homeostasis in gill tissues. This study is the first to demonstrate, in fish and in wild populations, that expression of NAKA, VDAC, NDH and COX are interrelated in gill tissues, and are involved in long-term acclimatisation to a salinity range between 0 and 100 psu.

  5. Deoxycholic Acid Injection

    MedlinePlus

    Deoxycholic acid injection is used to improve the appearance and profile of moderate to severe submental fat ('double chin'; fatty tissue located under the chin). Deoxycholic acid injection is in a class of medications called ...

  6. Early secondary osteoplastic closure of the residual alveolar cleft in combination with orthodontic treatment.

    PubMed

    Freihofer, H P; Kuijpers-Jagtman, A M

    1989-12-01

    In 84 early secondary bone graftings, rib and chin transplants were used. While good overall results are obtained, comparison of the two types of graft show that the cases with bone from the chin clearly do better.

  7. Aping our ancestors

    NASA Astrophysics Data System (ADS)

    Ennos, Roland

    2014-08-01

    Roland Ennos argues that the abilities of the great apes to cope in the dangerous mechanical environment of the forest canopy are part of the human species' intellectual inheritance and are intimately connected with our abilities as physicists.

  8. How Exercise Can Help

    MedlinePlus Videos and Cool Tools

    ... be active. That is, they need to improve muscle tone around the joint -- it actually protects the joint. Dr. Roland Moskowitz: If you strengthen the muscles and stabilize the joint, you decrease the instability ...

  9. Scent marking by the male domestic rabbit (Oryctolagus cuniculus) is stimulated by an object's novelty and its specific visual or tactile characteristics.

    PubMed

    Hoffman, Kurt L; Hernández Decasa, D M; Beyer Ruiz, M E; González-Mariscal, Gabriela

    2010-03-01

    "Chinning" is a stereotyped scent marking behavior of domestic rabbits, in which the animal rubs the underside of its chin against objects in order to deposit scent gland secretions. Although the long-term maintenance of chinning requires circulating gonadal steroids, little is known about the acute regulation of this behavior. To define specific environmental stimuli that engage the chinning motor pattern, male rabbits were placed into an open field arena containing markable objects ("standard" bricks, "tall" bricks, or polished onyx spheres), observed for 30 min, returned to the home cage for 5 min, and then placed in the open field arena for another 30 min. During the 5 min interim: (1) the location of the open field or the spatial orientation of the objects within it were changed, (2) the olfactory or (3) visual characteristics of the objects were changed; or (4) no changes were made. Chinning and ambulation habituated to each type of object across the first 30 min, and bricks elicited more chinning than polished onyx spheres. In the second 30 min test, chinning was re-stimulated only when the original objects were replaced by visually different ones that had preferred characteristics. Ambulatory behavior was increased by changing the location of the open field arena, while modifying the olfactory characteristics of the objects had no effect on chinning or ambulation. These results indicate that scent marking is stimulated by object novelty and by the visual and/or tactile characteristics of the objects being marked.

  10. 75 FR 43199 - Alaska Native Claims Selection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... approving the conveyance of surface estate for certain lands to Beaver Kwit'chin Corporation, pursuant to... Doyon, Limited when the surface estate is conveyed to Beaver Kwit'chin Corporation. The lands are in the vicinity of Beaver, Alaska, and are located in: Fairbanks Meridian, Alaska T. 16 N., R. 1 E., Secs. 1 to...

  11. 75 FR 71648 - Federal Motor Vehicle Safety Standards, Child Restraint Systems; Hybrid III 10-Year-Old Child...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... with the seat back. Only one head injury case was associated with self contact (head contact with knee... readings due to chin-to-chest contact, NHTSA published the 2008 SNPRM to propose a NHTSA-developed... experience stiff contact between its chin and upper sternal bib region which may result in an...

  12. The Scholarship of Teaching and Learning in Teaching Sociology: 1973-2009

    ERIC Educational Resources Information Center

    Paino, Maria; Blankenship, Chastity; Grauerholz, Liz; Chin, Jeffrey

    2012-01-01

    This article updates and extends research by Baker and Chin, who tracked changes in studies published in Teaching Sociology from 1973 to 1983 (Baker) and 1984 to 1999 (Chin). The current study traces manuscripts published in "Teaching Sociology" from 2000 to 2009. We examine both who publishes in the journal and what gets published. In particular,…

  13. Accuracy of a Computer-Aided Surgical Simulation (CASS) Protocol for Orthognathic Surgery: A Prospective Multicenter Study

    PubMed Central

    Hsu, Sam Sheng-Pin; Gateno, Jaime; Bell, R. Bryan; Hirsch, David L.; Markiewicz, Michael R.; Teichgraeber, John F.; Zhou, Xiaobo; Xia, James J.

    2012-01-01

    Purpose The purpose of this prospective multicenter study was to assess the accuracy of a computer-aided surgical simulation (CASS) protocol for orthognathic surgery. Materials and Methods The accuracy of the CASS protocol was assessed by comparing planned and postoperative outcomes of 65 consecutive patients enrolled from 3 centers. Computer-generated surgical splints were used for all patients. For the genioplasty, one center utilized computer-generated chin templates to reposition the chin segment only for patients with asymmetry. Standard intraoperative measurements were utilized without the chin templates for the remaining patients. The primary outcome measurements were linear and angular differences for the maxilla, mandible and chin when the planned and postoperative models were registered at the cranium. The secondary outcome measurements were: maxillary dental midline difference between the planned and postoperative positions; and linear and angular differences of the chin segment between the groups with and without the use of the template. The latter was measured when the planned and postoperative models were registered at mandibular body. Statistical analyses were performed, and the accuracy was reported using root mean square deviation (RMSD) and Bland and Altman's method for assessing measurement agreement. Results In the primary outcome measurements, there was no statistically significant difference among the 3 centers for the maxilla and mandible. The largest RMSD was 1.0mm and 1.5° for the maxilla, and 1.1mm and 1.8° for the mandible. For the chin, there was a statistically significant difference between the groups with and without the use of the chin template. The chin template group showed excellent accuracy with largest positional RMSD of 1.0mm and the largest orientational RSMD of 2.2°. However, larger variances were observed in the group not using the chin template. This was significant in anteroposterior and superoinferior directions, as in

  14. Oscillatory brain states interact with late cognitive components of the somatosensory evoked potential.

    PubMed

    Reinacher, Matthias; Becker, Robert; Villringer, Arno; Ritter, Petra

    2009-09-30

    The question of interaction between ongoing neuronal activity and evoked responses has been addressed for different species, sensory systems and measurement modalities. Among other findings, there is converging evidence for an interaction of occipital alpha-rhythm amplitude with the visual evoked potential. Here, we test the hypothesis that the modulatory role of an ongoing rhythm might not be confined to the visual system and the occipital alpha rhythm, but instead may be generalized to other sensory systems. Using an online EEG analysis approach, we investigated the influence of the Rolandic alpha-rhythm on the somatosensory evoked potential (SEP). We triggered vibrotactile stimulation during periods of high Rolandic alpha-rhythm amplitude. Analysis revealed significant effects of pre-stimulus Rolandic alpha amplitude on the amplitude of the N140 and P260 components of the SEP, known to be linked to cognitive processing, but not on early sensory components. The N140-P260 complex shows a different focus in topography than the early sensory components and the pre-stimulus Rolandic alpha rhythm. These results indicate an involvement of Rolandic alpha-rhythm in higher cognitive processing. In more general terms--and in the context of similar studies in the visual system--our findings suggest that modulation of late EP components by ongoing rhythms might be a characteristic and possibly universal feature of sensory systems. PMID:19589356

  15. Relevance of ovarian signaling for the early behavioral transition from estrus to pregnancy in the female rabbit.

    PubMed

    Hoffman, K L; González-Mariscal, G

    2007-11-01

    During estrus, the female domestic rabbit (Oryctolagus cuniculus) displays scent marking behavior (chinning), which is immediately inhibited after mating, temporarily recovers, and then declines and remains inhibited across pregnancy. Chinning is inhibited by progesterone (P) and the activation of the progesterone receptor (PR), but it is unlikely that P participates in the "acute" (immediate) or "early" inhibition of chinning (24 to 96 h post-mating, before plasma P levels rise). Since PR is activated in a ligand-independent manner by a variety of signaling molecules, some of which (e.g., GnRH) are also associated with reflexive ovulation in this species, we hypothesized that neurochemical/neuroendocrine signals associated with mating activate PR, resulting in the inhibition of chinning. In Experiment 1, we tested whether the PR antagonist, RU486 (20 mg, injected s.c. at -1 h, or at -7 h and +3 h relative to mating) prevented the post-mating inhibition of chinning in intact females. RU486 did not prevent the post-mating decline in chinning, indicating that PR activation associated with mating is not necessary for this effect. In Experiment 2, we used ovariectomized (OVX), estradiol benzoate (EB)-treated females to test the hypothesis that ovarian signaling is necessary for the post-mating inhibition of chinning. The acute inhibition of chinning occurred in OVX females, but the early inhibition was absent. We conclude that ovarian signaling is necessary for the early, but not acute, post-mating inhibition of chinning. The PR seems not to participate in either of these phases.

  16. Integral inversion to Fraunhofer diffraction for particle sizing.

    PubMed

    Cao, Zhang; Xu, Lijun; Ding, Jie

    2009-09-01

    A new solution to the inversion of Fraunhofer diffraction for particle sizing was introduced. Compared with the well-known Chin-Shifrin inversion, it is an inversion of the form of integral transform and less sensitive to noise. Simulation results with noise-contaminated data were obtained and showed that the new inversion is better than the Chin-Shifrin inversion. Especially when the particle diameter was small, the new inversion still performed well, whereas the Chin-Shifrin inversion did not converge.

  17. Impaired social behavior in children with benign childhood epilepsy with centrotemporal spikes.

    PubMed

    Genizi, Jacob; Shamay-Tsoory, Simone G; Shahar, Eli; Yaniv, Shoshana; Aharon-Perez, Judith

    2012-02-01

    The aim of the present study was to assess the emotional and cognitive aspects of social cognition among patients with rolandic epilepsy. A computerized neuropsychological battery was used for cognitive evaluation. Affective and cognitive social cognition were evaluated using two computerized Theory of Mind tasks. Cognitive abilities and social behavior of 15 children, diagnosed with rolandic epilepsy, ages 7 to 13 years were assessed and compared with 15 age- and education-matched healthy controls. Compared with controls, the epileptic patients had lower scores on verbal and visual learning rate parameters and on verbal processing and were significantly impaired on "affective Theory of Mind" tasks but not on "cognitive Theory of Mind" conditions. Our findings raise the possibility that rolandic epilepsy may affect neural networks affecting cognition and mediating social cognition essential for social behavior, thus challenging the benign nature of the condition. PMID:21868370

  18. The role of the right hemisphere in the control of speech prosody in propositional and affective contexts.

    PubMed

    Shapiro, B E; Danly, M

    1985-05-01

    Sixteen right-handed adult males with localized insult to either the right or left hemisphere and five control subjects without brain damage read aloud target sentences embedded in paragraphs, while intoning their voices in either a declarative, interrogative, happy, or sad mode. Acoustical analysis of the speech wave was performed. Right-anterior (pre-Rolandic) and right-central (pre- and post-Rolandic) brain-damaged patients spoke with less pitch variation and restricted intonational range across emotional and nonemotional domains, while patients with right posterior (post-Rolandic) damage had exaggerated pitch variation and intonational range across both domains. No such deficits were found in patients with left posterior damage, whose prosody was similar to that of normal control subjects. It is suggested that damage to the right hemisphere alone may result in a primary disturbance of speech prosody that may be independent of the disturbances in affect often noted in right-brain-damaged populations. PMID:4027566

  19. Ian Wallace (Profile).

    ERIC Educational Resources Information Center

    Stott, Jon C.

    1989-01-01

    Interviews Canadian children's author-illustrator Ian Wallace. Discusses the development of several of Wallace's books, including "Chin Chiang and the Dragon's Dance" and "The Sparrow's Song," as well as his development as an artist. (MM)

  20. Rosacea (image)

    MedlinePlus

    Rosacea is a condition where the area of the cheeks, nose, chin, forehead, or eyelids become inflamed. ... vessels, swelling, or skin eruptions similar to acne. Rosacea occurs most often in fair skinned people, particularly ...

  1. Bitter Melon

    MedlinePlus

    African Cucumber, Ampalaya, Balsam Pear, Balsam-Apple, Balsambirne, Balsamo, Bitter Apple, Bitter Cucumber, Bitter Gourd, Bittergurke, Carilla Fruit, Carilla Gourd, Cerasee, Chinli-Chih, Cundeamor, Fructus Mormordicae Grosvenori, Karavella, Kathilla, ...

  2. Jaw Injuries and Disorders

    MedlinePlus

    ... chin. The joint where the mandible meets your skull is the temporomandibular joint. Jaw problems include Fractures Dislocations Temporomandibular joint dysfunction Osteonecrosis, which happens when your bones lose their blood supply Cancers Treatment of jaw problems depends on the cause.

  3. For Aging Blacks, 'Golden Years' Often Marred by Disability

    MedlinePlus

    ... lifetime of disadvantage," Chin said. "Compared to whites, African-Americans have worse education, lower income and fewer social ties, all leading to worse health. "African-Americans are more likely to lack health insurance, and ...

  4. Genioplasty.

    PubMed

    Abadi, Mohammad; Pour, Omid Barahmand

    2015-10-01

    With increasing aesthetic awareness, in addition to the forehead, nose, and cheekbone prominence, the chin nowadays is seen as one of the most important parts of the facial skeleton. The size and location of these areas of the skeleton in relation to the skull base and their three-dimensional positional relationship to each other are essential and contribute the individuality of a human face. The position of the chin has a strong influence on the assessment of the facial harmony; its different types and forms dominate the appearance. Furthermore, the expression of the chin is equated with character traits and thus it is an important component of the profile forms. Genioplasty is a routine procedure for the correction of aesthetic and functional deformity of the chin region. It is therefore one of the contour-enhancing surgical methods. PMID:26579866

  5. [Condylar hyperplasia. Early detection is desired].

    PubMed

    van der Zwan, J

    1998-12-01

    When single-sided excessive condylar growth is detected in time, removal of the affected condyle is sufficient. In cases of late detection, extensive surgery of upper and lower jaw and the chin may be necessary. PMID:11928146

  6. 21 CFR 878.3500 - Polytetrafluoroethylene with carbon fibers composite implant material.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES... material intended to be implanted during surgery of the chin, jaw, nose, or bones or tissue near the eye...

  7. 21 CFR 878.3500 - Polytetrafluoroethylene with carbon fibers composite implant material.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES... material intended to be implanted during surgery of the chin, jaw, nose, or bones or tissue near the eye...

  8. 21 CFR 878.3500 - Polytetrafluoroethylene with carbon fibers composite implant material.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES... material intended to be implanted during surgery of the chin, jaw, nose, or bones or tissue near the eye...

  9. 21 CFR 878.3500 - Polytetrafluoroethylene with carbon fibers composite implant material.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES... material intended to be implanted during surgery of the chin, jaw, nose, or bones or tissue near the eye...

  10. 21 CFR 878.3500 - Polytetrafluoroethylene with carbon fibers composite implant material.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES... material intended to be implanted during surgery of the chin, jaw, nose, or bones or tissue near the eye...

  11. Communication by olfactory signals in rabbits: its role in reproduction.

    PubMed

    Melo, Angel I; González-Mariscal, Gabriela

    2010-01-01

    Rabbits use a variety of olfactory signals to transmit information related with reproduction. Such cues are produced in skin glands (submandibular, anal, Harder's, lachrymal, preputial) and the mammary gland-nipple complex. Some signals are transmitted by active behaviors, for example, chin-marking, urination, and defecation, while others are transmitted passively (e.g., mammary pheromone (MP) and inguinal gland secretions). We show that sex steroids regulate: chinning frequency and the chin gland's size, weight and secretory activity in bucks and does by acting on specific brain regions or on the chin gland, respectively. The "mammary pheromone," identified in milk as 2-methyl-but-2-enal, is essential for guiding the pups to the nipples, but its origin (mammary gland, ventral skin, nipple) remains to be determined. Estradiol, progesterone, and prolactin regulate the emission of an olfactory cue that also triggers nipple-search behavior in the pups, but its chemical identity and relation with the MP are unclear.

  12. 1. Historic American Buildings Survey E. W. Russell, Photographer, September ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey E. W. Russell, Photographer, September 15, 1936 GATE IN FRONT OF 201 GOVERNMENT STREET - 201 Government Street (Iron Gate), Moved to Spring Hill Avenue & Riviere du Chin Road, Mobile, Mobile County, AL

  13. Facial nerve palsy due to birth trauma

    MedlinePlus

    ... way on both sides while crying No movement (paralysis) on the affected side of the face (from the forehead to the chin in severe ... relieve pressure on the nerve. Infants with permanent paralysis need special therapy.

  14. Teebi hypertelorism syndrome: additional cases.

    PubMed

    Machado-Paula, Ligiane Alves; Guion-Almeida, Maria Leine

    2003-03-01

    We report on two unrelated Brazilian boys who have craniofacial and digital anomalies resembling those reported with Teebi hypertelorism syndrome. Additional features such as cleft lip and palate, large uvula, atypical chin and abnormal scapulae were observed.

  15. 42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... l.p.m. Number of tests Minimum life minutes 1 Chest-mounted or back-mounted gas mask (as received) 20,000 64 3 12 Chest-mounted or back-mounted gas mask (equilibrated) 20,000 32 4 12 Chin-style gas mask (as received) 5,000 64 3 12 Chin-style gas mask (equilibrated) 5,000 32 4 12 Chemical...

  16. 42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... l.p.m. Number of tests Minimum life minutes 1 Chest-mounted or back-mounted gas mask (as received) 20,000 64 3 12 Chest-mounted or back-mounted gas mask (equilibrated) 20,000 32 4 12 Chin-style gas mask (as received) 5,000 64 3 12 Chin-style gas mask (equilibrated) 5,000 32 4 12 Chemical...

  17. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  18. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  19. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  20. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  1. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  2. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  3. 29 CFR 4.101 - Official rulings and interpretations in this subpart.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... incorrect. See for example, Skidmore v. Swift & Co., 323 U.S. 134 (1944); Roland Co. v. Walling, 326 U.S... responsibilities of administration and enforcement (Skidmore v. Swift & Co., 323 U.S. 134 (1944)). In order that... informed judgment to which courts and litigants may properly resort for guidance” (Skidmore v. Swift &...

  4. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  5. 41 CFR 50-201.2 - Administration of the Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 10 of the Portal-to-Portal Act of 1947 (61 Stat. 84, 29 U.S.C. 251, et seq., discussed in 29 CFR part.... (“Skidmore v. Swift & Co.”, 323 U.S. 134 (1944), “Roland Co. v. Walling”, 326 U.S. 657 (1946);...

  6. Empire: An Analytical Category for Educational Research

    ERIC Educational Resources Information Center

    Coloma, Roland Sintos

    2013-01-01

    In this article Roland Sintos Coloma argues for the relevance of empire as an analytical category in educational research. He points out the silence in mainstream studies of education on the subject of empire, the various interpretive approaches to deploying empire as an analytic, and the importance of indigeneity in research on empire and…

  7. On Universals, Cultural Variations and Individual Uniqueness: Throwing down the Gauntlet in Giftedness Research

    ERIC Educational Resources Information Center

    Garces-Bacsal, Rhoda Myra

    2012-01-01

    Roland S. Persson's (2012a) piece is extremely comprehensive, timely and very relevant especially in light of a growing appreciation of cultural diversity and the emergence of a global community--which is an inevitable offshoot of globalisation that goes beyond world economy and international markets. It covers multiple themes; ranging from…

  8. The Myth in the Discourse.

    ERIC Educational Resources Information Center

    Breen, Myles; Corcoran, Farrel

    Reflecting the ideas of Roland Barthes, this paper examines the nature and importance of myth as a type of speech. The investigation proceeds by discussing myth from the perspectives of both traditional and contemporary disciplines, then considers the universality of myth, its religious impulse, and its functions. Using examples from television…

  9. 1967: The Birth of "The Death of the Author"

    ERIC Educational Resources Information Center

    Logie, John

    2013-01-01

    Roland Barthes's "The Death of the Author" is a foundational text for scholars who are addressing questions of authorship and textual ownership in English studies and its neighboring disciplines. Barthes's essay is typically presented without significant attention to the circumstances and context surrounding its initial English publication in 1967…

  10. Musical Hunger: A Philosophical Testimonial of Miseducation

    ERIC Educational Resources Information Center

    Laird, Susan

    2009-01-01

    Reflecting upon Simone Weil's conception of beauty as food, this essay proposes musical hunger as a metaphoric way of understanding a particular species of "cultural miseducation" as conceived by Jane Roland Martin, that disadvantages children musically and perhaps therefore also spiritually. It examines such musical miseducation with regard to an…

  11. Benign Childhood Focal Epilepsies: Assessment of Established and Newly Recognized Syndromes

    ERIC Educational Resources Information Center

    Panayiotopoulos, Chrysostomos P.; Michael, Michael; Sanders, Sue; Valeta, Thalia; Koutroumanidis, Michael

    2008-01-01

    A big advance in epileptology has been the recognition of syndromes with distinct aetiology, clinical and EEG features, treatment and prognosis. A prime and common example of this is rolandic epilepsy that is well known by the general paediatricians for over 50 years, thus allowing a precise diagnosis that predicts an excellent prognosis. However,…

  12. 75 FR 62535 - Farm Credit Administration Board; Sunshine Act; Regular Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    .... SUMMARY: Notice is hereby given, pursuant to the Government in the Sunshine Act (5 U.S.C. 552b(e)(3)), of... October 14, 2010, from 9 a.m. until such time as the Board concludes its business. FOR FURTHER INFORMATION CONTACT: Roland E. Smith, Secretary to the Farm Credit Administration Board, (703) 883-4009, TTY (703)...

  13. 75 FR 17140 - Sunshine Act; Farm Credit Administration Board; Regular Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ...: Notice is hereby given, pursuant to the Government in the Sunshine Act (5 U.S.C. 552b(e)(3)), of the..., 2010, from 9 a.m. until such time as the Board concludes its business. FOR FURTHER INFORMATION CONTACT: Roland E. Smith, Secretary to the Farm Credit Administration Board, (703) 883-4009, TTY (703)...

  14. A Distinction between Emic Research and Etic Research

    ERIC Educational Resources Information Center

    Gallagher, James J.

    2012-01-01

    Roland S. Persson (2012a) has made a significant contribution to the literature in pointing out the potential for cultural bias in the body of research related to gifted and talented. He encourages a distinction between emic research, where the results are limited to a particular culture and etic research, where the results can be generalised to…

  15. A Catalyst for Charting a Path to Research Validity in the Field of Gifted Education

    ERIC Educational Resources Information Center

    Sisk, Dorothy A.

    2012-01-01

    Roland S. Persson's (2012a) article addresses a concern that many educators have stressed in their theoretical models, namely the importance of the interaction between the individual and the environment, and the impact of culture on not only values and beliefs, but on behaviour. As Persson (2012a) points out these models all have merit, but he…

  16. 76 FR 19765 - Toutant Hydropower Inc.; Notice of Application Accepted for Filing, Soliciting Comments, Motions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... Energy Regulatory Commission Toutant Hydropower Inc.; Notice of Application Accepted for Filing... Hydropower Inc. e. Name of Project: M.S.C. (Toutant) Hydroelectric Project. f. Location: The project is..., 16 U.S.C. 791a-825r. h. Applicant Contact: Roland Toutant, Toutant Hydropower, Inc., 80 Bungay...

  17. The Role of the State and the Social Partners: Mechanisms and Spheres of Influence.

    ERIC Educational Resources Information Center

    Vocational Training, 1992

    1992-01-01

    This serial issue is devoted to clarifying the attitudes of the various parties or "social partners" to vocational training in the Member States of the European Community. Following an editorial introducing the topic are these articles: "The Community Social Dialogue" (Roland Tavitian); "From the Market Jungle to the Social Dialogue: Vocational…

  18. No Child Left Behind and the Spectacle of Failing Schools: The Mythology of Contemporary School Reform

    ERIC Educational Resources Information Center

    Granger, David A.

    2008-01-01

    This article discusses what David Berliner (2005) has called the perverse "spectacle of fear" (208) surrounding issues of teacher quality and accountability in contemporary school reform. Drawing principally on the critical semiotics of Roland Barthes' essay, "The World of Wrestling" (1957), it examines the way that this spectacle works to…

  19. Expression of Self-Concept and Adjustment against Repeated Aggressions: The Case of a Longitudinal Study on School Bullying

    ERIC Educational Resources Information Center

    Houbre, Barbara; Tarquinio, Cyril; Lanfranchi, Jean-Baptiste

    2010-01-01

    Bullying between students in the school setting is an increasing problem. Bullying can be defined as any form of repeated mental or physical violence carried out by one or several individuals on a person who is not capable of defending himself (Roland and Idsoe, "Aggress Behav" 27:446-462, 2001). The aim of this paper is to observe the expression…

  20. Planning and Implementing Augmentative Communication Service Delivery, 2: Proceedings of the National Planners Conference on Assistive Device Service Delivery.

    ERIC Educational Resources Information Center

    Coston, Caroline A., Ed.

    The document consists of 30 author contributed chapters concerned with augmentative communication service delivery. Chapter titles and authors are: "Communication Options for Persons Who Cannot Speak: Planning for Service Delivery" (David Beukelman); "Planning Service Delivery Systems" (Roland Hahn II); "Planning Ohio's Augmentative Communication…

  1. The Proper Place of Theory in Educational History?

    ERIC Educational Resources Information Center

    Urban, Wayne J.

    2011-01-01

    In this article, the author talks about the proper place of theory in educational history and shares his comments on the essays by Eileen Tamura, Carolyn Eick, and Roland Coloma. Eileen Tamura's positing of most educational historians as practitioners of narrative history is surely on the mark. She invites historians of education to investigate…

  2. Das Sprachlabor und der Audiovisuelle Unterricht (The Language Laboratory and Audiovisual Instruction).

    ERIC Educational Resources Information Center

    Freudenstein, Reinhold, Ed.

    Four articles, written in German, discuss such aspects of the language laboratory as: teaching pronunciation in the laboratory (Heinrich Schrand), the dummy-element in transformational grammar (Helmut Heuer), testing in the language laboratory (Kenneth S. Leigh), and language laboratory work in Finland (Roland Freihoff). Nine book reviews on…

  3. Literary Theory and the Notion of Difficulty. Report Series 4.7.

    ERIC Educational Resources Information Center

    Touponce, William

    The works of French literary theorists Jacques Lacan, Jacques Derrida, and Roland Barthes reflect a view of the text as the primary object of investigation for any discipline in the human sciences. Each of the three has been involved with pedagogical reforms within French cultural institutions: Derrida with the teaching of philosophy, Lacan with…

  4. Bullying among Students and Its Consequences on Health

    ERIC Educational Resources Information Center

    Houbre, Barbara; Tarquinio, Cyril; Thuillier, Isabelle; Hergott, Emmanuelle

    2006-01-01

    Violence among students at school is an ever-growing problem. Bullying can be defined as all forms of repeated physical or mental violence performed by an individual on another person who is not capable of defending him/herself (Roland & Idsoe, 2001). The three studies conducted here reveal some of the characteristics and implications of this type…

  5. Revision Hope: Writing Disruption in Composition Studies.

    ERIC Educational Resources Information Center

    Jung, Julie

    1997-01-01

    Uses Roland Barthes's metaphor of the "punctum" to explore the transformative potential of disruptions. Argues that writing teachers have been trained to read disruption in texts and classrooms as "evidence of poor taste or failed pedagogy," but that disruptions delay closure and thereby create spaces wherein theories and relationships can be…

  6. 75 FR 67408 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  7. 76 FR 2929 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ....gpoaccess.gov/fr/ . A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  8. 75 FR 3947 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ....gpoaccess.gov/ fr/. A consolidated listing of all authorities as of June 30 is also published each year. The... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  9. 76 FR 53157 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... Federal Register at http://www.gpoaccess.gov/fr/ fr/. A consolidated listing of all authorities as of June... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... excepted service as required by 5 CFR 213.103. FOR FURTHER INFORMATION CONTACT: Roland Edwards,...

  10. European Consciousness: Towards Defining a Complex Concept and Its Educational Significance (Europaisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung)

    ERIC Educational Resources Information Center

    Jobst, Solvejg

    2005-01-01

    The present study aims at a definition of "European consciousness". In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmuller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain identification…

  11. Educational Studies of Cosmic Rays with a Telescope of Geiger-Muller Counters

    ERIC Educational Resources Information Center

    Wibig, T.; Kolodziejczak, K.; Pierzynski, R.; Sobczak, R.

    2006-01-01

    A group of high school students (XII Liceum) in the framework of the Roland Maze Project has built a compact telescope of three Geiger-Muller counters. The connection between the telescope and a PC computer was also created and programmed by students involved in the Project. This has allowed students to use their equipment to perform serious…

  12. Goals and Objectives of National Science Policy. Science Policy Study--Hearings Volume 1. Hearings before the Task Force on Science Policy of the Committee on Science and Technology, House of Representatives, Ninety-Ninth Congress, First Session (February 28; March 7, 21, 28; April 4, 1985). No. 46.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Science and Technology.

    These hearings, which focused on the goals and objectives of national science policy, include discussions, questions and answers for the record, and, when applicable, prepared statements. Individuals appearing during the hearings include: (1) George C. Pimentel; (2) Alex Roland; (3) John S. Foster, Jr.; (4) James B. Wyngaarden; and (5) Lewis M.…

  13. Bibliographic Annual in Speech Communication: 1974. Volume 5.

    ERIC Educational Resources Information Center

    Kennicott, Patrick C., Ed.

    This annotated bibliography is an annual volume devoted to maintaining a record of graduate work in speech communication, providing abstracts of doctoral dissertations, and making subject area bibliographies available. The contents of this volume include "Studies in Mass Communication: A Selected Bibliography, 1973" by Roland C. Johnson and…

  14. The Time Is Ripe (Again)

    ERIC Educational Resources Information Center

    Barth, Roland S.

    2013-01-01

    "It's always been a promising time for teacher leadership. It's just never been a successful time," writes noted educator Roland Barth. Why? Barth points to five obstacles: administrator resistance, the taboo in teaching against elevating oneself higher than one's peers, the fact that teachers' plates are full, the…

  15. Black Superintendents of Selected American Cities.

    ERIC Educational Resources Information Center

    Negro History Bulletin, 1980

    1980-01-01

    Presents photographs of 12 Black superintendents of urban school districts. They are: J. Jerome Harris, Ronald Lewis, Willie W. Herenton, Robert R. Wheeler, Alonzo A. Crim, Roland N. Patterson, Jean Franklin Emmons, Charles R. Thomas, Richard C. Hunter, Arthur Jefferson, Ulysses Byas, and Howard E. White, Sr. (GC)

  16. Some Thoughts on "Cultural Variation and Dominance in a Globalised Knowledge-Economy"

    ERIC Educational Resources Information Center

    Yang, Yang; Gentry, Marcia

    2012-01-01

    To view giftedness research in a global context is an important and desirable attempt. Roland S. Persson (2012a), in the target article entitled Cultural Variation and Dominance in a Globalised Knowledge-Economy: Towards a Cultural-Sensitive Research Paradigm in the Science of Giftedness, delivers thought-provoking views in the cultural influences…

  17. No Such Thing as a Consensus: Olive Banks and the Sociology of Education

    ERIC Educational Resources Information Center

    Delamont, Sara

    2008-01-01

    The title of this article comes from the editorial written for this journal by Olive Banks, Len Barton, Roger Dale, David Hargreaves, Roland Meighan, Ivan Reid and Graham Vulliamy (Banks et al. 1980, 4) that appeared in its first issue, and set out its remit. The seven scholars who wrote that editorial pledged to "publish high quality work of any…

  18. A Semiotic Perspective on the Technical and Professional Writing Assignment.

    ERIC Educational Resources Information Center

    Westmoreland, Kay

    1995-01-01

    Uses central ideas from Roland Barthes's essays on connotative semiotics as a rationale for directing students in technical and professional writing classes to develop the critical reflex to analyze and then make judgments about the values implied by connotative systems. (SR)

  19. The Aims of Education and the Leap of Freedom

    ERIC Educational Resources Information Center

    Yun, SunInn

    2014-01-01

    This paper considers the place of freedom in discussions of the aims of education. Bearing in mind remarks of R.S. Peters to the affect that the singling out of aims can "fall into the hands of rationalistically minded curriculum planners", it begins by considering the views of Roland Reichenbach regarding Bildung and his account of this…

  20. Evaluation of the anterior mandibular donor site one year after secondary reconstruction of an alveolar cleft: 3-dimensional analysis using cone-beam computed tomography.

    PubMed

    van Bilsen, M W T; Schreurs, R; Meulstee, J W; Kuijpers, M A R; Meijer, G J; Borstlap, W A; Bergé, S J; Maal, T J J

    2015-10-01

    The aim of this study was to analyse changes in the volume of the chin after harvest of a bone graft for secondary reconstruction of an alveolar cleft. Cone-beam computed tomographic (CT) scans of 27 patients taken preoperatively, and immediately and one year postoperatively, were analysed, and 3-dimensional hard-tissue reconstructions made. The hard-tissue segmentation of the scan taken one year postoperatively was subtracted from the segmentation of the preoperative scan to calculate the alteration in the volume of bone at the donor site (chin). A centrally-orientated persistent concavity at the buccal side of the chin was found (mean (range) 160 (0-500) mm(3)). At the lingual side of the chin, a central concavity remained (mean (range) volume 20 (0-80) mm(3)). Remarkably, at the periphery of this concavity there was overgrowth of new bone (mean (range) volume 350 (0-1600) mm(3)). Re-attachment of the muscles of the tongue resulted in a significantly larger central lingual defect one year postoperatively (p=0.01). We also measured minor alterations in volume of the chin at one year. Whether these alterations influence facial appearance and long term bony quality is to be the subject of further research.

  1. KSC-04PD-1424

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. Workers in the Orbiter Processing Facility lift the Reinforced Carbon-Carbon (RCC) chin panel to install on Discovery. The chin panel is the smile-shaped section of RCC directly below the nose cap that provides a thermal barrier during re-entry. The nose cap, with chin panel, was removed from the vehicle in the summer of 2003 and returned to the vendor, where it underwent numerous forms of Non-Destructive Evaluation. These tests included X-ray, ultrasound and eddy current to ensure its structural integrity prior to reinstallation. Discovery is designated as the Return to Flight vehicle for mission STS-114, no earlier than March 2005.

  2. KSC-04PD-1427

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. Workers in the Orbiter Processing Facility check the placement of the Reinforced Carbon-Carbon chin panel on Discovery. The chin panel is the smile-shaped section of RCC directly below the nose cap that provides a thermal barrier during re-entry. The nose cap, with chin panel, was removed from the vehicle in the summer of 2003 and returned to the vendor, where it underwent numerous forms of Non-Destructive Evaluation. These tests included X-ray, ultrasound and eddy current to ensure its structural integrity prior to reinstallation. Discovery is designated as the Return to Flight vehicle for mission STS-114, no earlier than March 2005.

  3. KSC-04PD-1423

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. Workers in the Orbiter Processing Facility prepare the Reinforced Carbon-Carbon (RCC) chin panel to install on Discovery. The chin panel is the smile-shaped section of RCC directly below the nose cap that provides a thermal barrier during re-entry. The nose cap, with chin panel, was removed from the vehicle in the summer of 2003 and returned to the vendor, where it underwent numerous forms of Non-Destructive Evaluation. These tests included X-ray, ultrasound and eddy current to ensure its structural integrity prior to reinstallation. Discovery is designated as the Return to Flight vehicle for mission STS-114, no earlier than March 2005.

  4. KSC-04PD-1425

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. Workers in the Orbiter Processing Facility lift the Reinforced Carbon-Carbon (RCC) chin panel into place on Discovery. The chin panel is the smile-shaped section of RCC directly below the nose cap that provides a thermal barrier during re-entry. The nose cap, with chin panel, was removed from the vehicle in the summer of 2003 and returned to the vendor, where it underwent numerous forms of Non-Destructive Evaluation. These tests included X-ray, ultrasound and eddy current to ensure its structural integrity prior to reinstallation. Discovery is designated as the Return to Flight vehicle for mission STS-114, no earlier than March 2005.

  5. KSC-04PD-1426

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. Workers in the Orbiter Processing Facility check the placement of the Reinforced Carbon-Carbon (RCC) chin panel on Discovery. . The chin panel is the smile- shaped section of RCC directly below the nose cap that provides a thermal barrier during re-entry. The nose cap, with chin panel, was removed from the vehicle in the summer of 2003 and returned to the vendor, where it underwent numerous forms of Non- Destructive Evaluation. These tests included X-ray, ultrasound and eddy current to ensure its structural integrity prior to reinstallation. Discovery is designated as the Return to Flight vehicle for mission STS-114, no earlier than March 2005.

  6. Bone remodeling to correct maxillary deficiency after growth cessation

    PubMed Central

    Showkatbakhsh, Rahman; Ghassemi, Alireza; Gerressen, Marcus; Ghassemi, Mehrangiz; Jamilian, Abdolreza; Mohammad, Shadab; Pal, Uma S.

    2012-01-01

    This case report presents a 22-year-old girl with class III malocclusion due to maxillary deficiency. The patient was referred for presurgical orthodontics; however, she rejected the surgery. This case was treated by means of Tongue appliance and slow palatal expansion, followed by lower fixed appliance, reverse chin cup, and upper fixed appliance. Tongue appliance and slow palatal expansion were used at the beginning of the treatment. After 6 months, reverse chin cup and lower fixed appliance were added. Six months later reverse chin cup was removed and upper fixed appliance was mounted. Positive overbite and over jet were achieved after 24 months of active treatment. Nasolabial angle also showed improvement. Nonsurgical treatment of adult class III patients is a difficult procedure; however, this patient was treated nonsurgically. PMID:23833499

  7. Common Errors in Digital Panoramic Radiographs of Patients with Mixed Dentition and Patients with Permanent Dentition

    PubMed Central

    Peretz, Benjamin; Gotler, Maya; Kaffe, Israel

    2012-01-01

    Purpose. To compare errors in digital panoramic radiographs of permanent and mixed dentitions. Methods. 143 and 146 digital radiographs of mixed and permanent dentitions were examined. Results. Significantly fewer errors presented in the mixed dentition. Positioning too forward significantly prevalent in the mixed dentition; slumped position and nonpositioning of chin properly were significantly prevailed in the permanent dentition. Blurred or shortened upper incisors were significantly more prevalent in the mixed dentition. Diagnostic ability could be improved by manipulating the brightness or contrast in nearly 45% of all radiographs. In the mixed dentition, tilting the chin down and a slumped position made the lower incisors significantly nondiagnostic. In the permanent dentition, tilting the chin down made the lower incisors to be significantly nondiagnostic. Conclusions. More errors were prevalent in panoramic radiographs of permanent dentitions. Properly positioning the patient is the most important factor in preventing a cascade of errors. PMID:22505905

  8. Study of Aerosol/Cloud/Radiation Interactions over the ARM SGP Site

    SciTech Connect

    Chuang, C; Chin, S

    2006-03-14

    While considerable advances in the understanding of atmospheric processes and feedbacks in the climate system have led to a better representation of these mechanisms in general circulation models (GCMs), the greatest uncertainty in predictability of future climate arises from clouds and their interactions with radiation. To explore this uncertainty, cloud resolving model has been evolved as one of the main tools for understanding and testing cloud feedback processes in climate models, whereas the indirect effects of aerosols are closely linked with cloud feedback processes. In this study we incorporated an existing parameterization of cloud drop concentration (Chuang et al., 2002a) together with aerosol prediction from a global chemistry/aerosol model (IMPACT) (Rotman et al., 2004; Chuang et al., 2002b; Chuang et al., 2005) into LLNL cloud resolving model (Chin, 1994; Chin et al., 1995; Chin and Wilhelmson, 1998) to investigate the effects of aerosols on cloud/precipitation properties and the resulting radiation fields over the Southern Great Plains.

  9. Primate experiments on mandibular growth direction.

    PubMed

    Tomer, B S; Harvold, E P

    1982-08-01

    Induced oral respiration in eight growing monkeys led to a lowering of the chin, a steeper mandibular plane angle, and an increase in the gonial angle as compared with eight control animals. The posterior border of the mandible maintained its normal inclination relative to the skull. The mandible underwent a posterior rotation in the experimental animals and an anterior rotation in the controls. The findings suggest that the position of the chin and the inclination of the mandibular plane are controlled by the balance between the suprahyoid and the orofacial muscles. Since the posterior border of the ramus undergoes gradual remodeling and maintains its normal inclination, it is assumed that the masticatory muscles are not significantly affected by the altered respiratory function. It is therefore concluded that the ramus with the masticatory muscles and the chin with its suprahyoid and orofacial muscles represent two relatively independent systems.

  10. Cone-Beam Computed Tomography Assessment of Lower Facial Asymmetry in Unilateral Cleft Lip and Palate and Non-Cleft Patients with Class III Skeletal Relationship

    PubMed Central

    Lin, Yifan; Chen, Gui; Fu, Zhen; Ma, Lian; Li, Weiran

    2015-01-01

    Introduction To evaluate, using cone-beam computed tomography (CBCT), both the condylar-fossa relationships and the mandibular and condylar asymmetries between unilateral cleft lip and palate (UCLP) patients and non-cleft patients with class III skeletal relationship, and to investigate the factors of asymmetry contributing to chin deviation. Methods The UCLP and non-cleft groups consisted of 30 and 40 subjects, respectively, in mixed dentition with class III skeletal relationships. Condylar-fossa relationships and the dimensional and positional asymmetries of the condyles and mandibles were examined using CBCT. Intra-group differences were compared between two sides in both groups using a paired t-test. Furthermore, correlations between each measurement and chin deviation were assessed. Results It was observed that 90% of UCLP and 67.5% of non-cleft subjects had both condyles centered, and no significant asymmetry was found. The axial angle and the condylar center distances to the midsagittal plane were significantly greater on the cleft side than on the non-cleft side (P=0.001 and P=0.028, respectively) and were positively correlated with chin deviation in the UCLP group. Except for a larger gonial angle on the cleft side, the two groups presented with consistent asymmetries showing shorter mandibular bodies and total mandibular lengths on the cleft (deviated) side. The average chin deviation was 1.63 mm to the cleft side, and the average absolute chin deviation was significantly greater in the UCLP group than in the non-cleft group (P=0.037). Conclusion Compared with non-cleft subjects with similar class III skeletal relationships, the subjects with UCLP showed more severe lower facial asymmetry. The subjects with UCLP presented with more asymmetrical positions and rotations of the condyles on axial slices, which were positively correlated with chin deviation. PMID:26237311

  11. Alchemy, Chinese versus Greek, an etymological approach: a rejoinder.

    PubMed

    Mahdihassan, S

    1988-01-01

    The theory generally accepted maintains that Alchemy arose at Alexandria as a child of Greek culture. It has two names, Chemeia as the earlier and Chumeia as the later. There is another theory that Alchemy arose in China. Its founder was the aged ascetic who longed after drugs of longevity. He first tried jade, next gold and cinnabar, but the ideal was a drug which was red like cinnabar and fire-proof like gold. But what was actually prepared was red colloidal gold or "calcined gold," by grinding gold granules in a decoction of an herb of longevity. It was called Chin-I; Chin = gold and I = plant juice. In Fukin dialect Chin-I = Kim-Iya. This was Arabicized, by pre-Islamic Arabs trading in silk with China, as Kimiya, whence arose Al-Kimiya and finally Al-chemy. It was first accepted by Bucharic speaking Copts in Egypt who transliterated Kimiya = Chemeia, pronouncing it as the Arabs did. With the increase of trade in silk the Chinese also went to Alexandria and helped the Greeks to translate Chin-I as Chrusozomion meaning, gold (making) ferment, instead of gold making plant juice. Consistent with this origin of the word Chemeia is the fact that the earlier Alchemists were not Greeks but probably Bucharic speaks Copts or Egyptians. The consumer of Chin-I or Chemeia became "a drug-made immortal" called Chin-Jen, Golden-Man. This was translated into Greek as Chrusanthropos. Thus the etymoloogy of two Greek words Chrusozomion and Chrusanthropos support the origin of the loan word, Chemeia as Chinese. To save space it is not proposed to discuss the origin of Chumeia.

  12. Simultaneous osseous genioplasty and meloplasty.

    PubMed

    Wider, T M; Spiro, S A; Wolfe, S A

    1997-04-01

    A review was done of the records of 50 patients who had osseous genioplasty performed at the same sitting as face lifting and, in many cases, submental lipectomy over a 20-year period by the senior author. The types of genioplasties were sliding advancement (40), lengthening with interpositional bone graft (7), and reduction (3). In 9 patients, chin implants were removed, generally because of inadequate chin projection or implant erosion. Three patients were operated on under local anesthesia, the remainder under general anesthesia. Associated procedures, done in 46 patients, included rhinoplasty, forehead lifting, blepharoplasty, lateral canthopexy, excision of buccal fat pads, reduction mammaplasty, and abdominoplasty. In 4 patients, associated maxillofacial procedures were performed, including Le Fort I and III osteotomies, two-jaw surgery, mandibular advancement with sagittal splitting, and orbital expansion. The perceived advantages of osseous genioplasty were greater versatility in dealing with problems in other than the sagittal plane, the possibility of greater chin projection, and a tightening of the submental musculature. Complications occurred in 10 patients. These included two hematomas requiring aspiration in the office, a prolapsed submandibular gland requiring later excision, a transient weakness of the marginal mandibular nerve, a transient numbness of the lower lip on one side, four revisions of scars resulting from the face lifting, and one localized wound infection in the parasymphyseal area that resolved with oral antibiotics. The most common complaint, which came from 8 female patients at some time from 1 month to 3 years postoperatively, was that the chin was "too strong." In 6 of these patients, most of whom were operated on early in the series, some of the chin projection was reduced by burring. Osseous genioplasty can be performed safely along with face lifting and submental lipectomy. The degree of advancement necessary in aesthetic

  13. KSC-04PD-1428

    NASA Technical Reports Server (NTRS)

    2004-01-01

    KENNEDY SPACE CENTER, FLA. Workers in the Orbiter Processing Facility complete the installation of the Reinforced Carbon- Carbon panel on Discovery. The chin panel is the smile-shaped section of RCC directly below the nose cap that provides a thermal barrier during re-entry. The nose cap, with chin panel, was removed from the vehicle in the summer of 2003 and returned to the vendor, where it underwent numerous forms of Non- Destructive Evaluation. These tests included X-ray, ultrasound and eddy current to ensure its structural integrity prior to reinstallation. Discovery is designated as the Return to Flight vehicle for mission STS-114, no earlier than March 2005.

  14. Tan, cinnabar, as drug of longevity prior to alchemy.

    PubMed

    Mahdihassan, S

    1984-01-01

    Alchemy as the art of gold making never existing and had no beginning. It arose as the cult of longevity using simples, like gold and cinnabar, as drugs of longevity. It became alchemy on making the first synthetic drug, Chin-Yeh, Gold-plus-herbal juice, and reached its ideal with Chin-Tan, Gold-plus-cinnabar. The former was red colloidal gold, the latter vermilion with traces of gold. As inscribed character Tan shows crude cinnabar, pulverized, lavagated and filtered on a rectangular piece of cloth.

  15. Efficient quantum secret sharing scheme with two-particle entangled states

    NASA Astrophysics Data System (ADS)

    Zhu, Zhen-Chao; Zhang, Yu-Qing; Fu, An-Min

    2011-04-01

    This paper proposes a protocol for multi-party quantum secret sharing utilizing four non-orthogonal two-particle entangled states following some ideas in the schemes proposed by Liu et al. (2006 Chin. Phys. Lett. 23 3148) and Zhang et al. (2009 Chin. Phys. B 18 2149) respectively. The theoretical efficiency for qubits of the new protocol is improved from 50% to approaching 100%. All the entangled states can be used for generating the private key except those used for the eavesdropping check. The validity of a probable attack called opaque cheat attack to this kind of protocols is considered in the paper for the first time.

  16. Fireworks under the microscope: a spectacular new species of Zodiomyces from the Thaxter collection.

    PubMed

    Rossi, Walter; Haelewaters, Danny; Pfister, Donald H

    2016-01-01

    A new species of Zodiomyces (Ascomycota, Laboulbeniales) is described, Z. rhizophorus, parasitic on a hydrophilid beetle (Coleoptera, Hydrophilidae) from Trinidad. This species was discovered during the examination of the slides of Laboulbeniales made by Roland Thaxter. It is characterized by numerous long, slender, multicellular and multiseriate outgrowths at the base of the receptacle. Thaxter's outstanding illustrations have set a standard in the field of mycology; we provide a review of the methods he employed in the preparation of these illustrations.

  17. Session: Reservoir Technology

    SciTech Connect

    Renner, Joel L.; Bodvarsson, Gudmundur S.; Wannamaker, Philip E.; Horne, Roland N.; Shook, G. Michael

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five papers: ''Reservoir Technology'' by Joel L. Renner; ''LBL Research on the Geysers: Conceptual Models, Simulation and Monitoring Studies'' by Gudmundur S. Bodvarsson; ''Geothermal Geophysical Research in Electrical Methods at UURI'' by Philip E. Wannamaker; ''Optimizing Reinjection Strategy at Palinpinon, Philippines Based on Chloride Data'' by Roland N. Horne; ''TETRAD Reservoir Simulation'' by G. Michael Shook

  18. Fireworks under the microscope: a spectacular new species of Zodiomyces from the Thaxter collection.

    PubMed

    Rossi, Walter; Haelewaters, Danny; Pfister, Donald H

    2016-01-01

    A new species of Zodiomyces (Ascomycota, Laboulbeniales) is described, Z. rhizophorus, parasitic on a hydrophilid beetle (Coleoptera, Hydrophilidae) from Trinidad. This species was discovered during the examination of the slides of Laboulbeniales made by Roland Thaxter. It is characterized by numerous long, slender, multicellular and multiseriate outgrowths at the base of the receptacle. Thaxter's outstanding illustrations have set a standard in the field of mycology; we provide a review of the methods he employed in the preparation of these illustrations. PMID:27055574

  19. 737 Windshear Tests, Orlando

    NASA Technical Reports Server (NTRS)

    1992-01-01

    NASA researchers evaluating wind shear sensor displays in the experimental flight deck at NASA's Boeing 737 research aircraft. During this flight test program, over 75 microbursts were penetrated at altitudes from 800-1100 ft to test the performance of radar, lidar and infrared wind shear sensors. Pictured from left to right are Wind Shear Program Manager Roland Bowles, NASA research pilot Lee Person, Wind Shear Program Deputy Manager Michael Lewis, NASA research engineer David Hinton, NASA research engineer Emedio Bracalante.

  20. Data-Based Methods for AB Initio Protein Structure Prediction

    SciTech Connect

    Dr Keith L. Frost

    2002-11-07

    OAK 270 - Per the DOE Project Officer ''Roland Hirsh'' Germantown, Md. The required final report for this award has been waived due to the fact Dr Keith Frost who was the P.I. on the research took a leave of absence at the end of March 2000, and left the university without an approval. The University adjusted their records to reflect this early termination; no further funding applied.

  1. Localization of sensorimotor cortex: the influence of Sherrington and Cushing on the modern concept.

    PubMed

    Uematsu, S; Lesser, R P; Gordon, B

    1992-06-01

    According to Penfield, the work of Charles Sherrington's laboratory forced a change from the long-held concept of a broad, overlapping sensorimotor cortex to the concept of a narrow, discrete pre-Rolandic motor cortex separate from the post-Rolandic sensory strip. Harvey Cushing, one of the founders of modern neurosurgery, coined the term narrow motor strip. Cushing also appears to have been the first to color the precentral gyrus in a mosaic pattern and to use red coloring for the motor cortex and blue for the sensory cortex. Cushing's red and blue color coding is still used in textbooks, nearly 100 years later. In this article, we review the historical evolution of and the evidence for the concept of narrow and discrete motor and sensory strips anterior and posterior to the Rolandic cortex. A review of the historical development of the concept and recent physiological studies reaffirms the proposition that the motor and sensory areas are much broader and more complex than they were thought to be in the classic teaching that originated with Sherrington and Cushing.

  2. Positron computed tomography studies of cerebral metabolic responses to complex motor tasks

    SciTech Connect

    Phelps, M.E.; Mazziotta, J.C.

    1984-01-01

    Human motor system organization was explored in 8 right-handed male subjects using /sup 18/F-fluorodeoxyglucose and positron computed tomography to measure cerebral glucose metabolism. Five subjects had triple studies (eyes closed) including: control (hold pen in right hand without moving), normal size writing (subject repeatedly writes name) and large (10-15 X normal) name writing. In these studies normal and large size writing had a similar distribution of metabolic responses when compared to control studies. Activations (percent change from control) were in the range of 12-20% and occurred in the striatum bilaterally > contralateral Rolandic cortex > contralateral thalamus. No significant activations were observed in the ipsilateral thalamus, Rolandic cortex or cerebellum (supplementary motor cortex was not examined). The magnitude of the metabolic response in the striatum was greater with the large versus normal sized writing. This differential response may be due to an increased number and topographic distribution of neurons responding with the same average activity between tasks or an increase in the functional activity of the same neuronal population between the two tasks (present spatial resolution inadequate to differentiate). When subjects (N=3) performed novel sequential finger movements, the maximal metabolic response was in the contralateral Rolandic cortex > striatum. Such studies provide a means of exploring human motor system organization, motor learning and provide a basis for examining patients with motor system disorders.

  3. Facial Prototype Formation in Children.

    ERIC Educational Resources Information Center

    Inn, Donald; And Others

    This study examined memory representation as it is exhibited in young children's formation of facial prototypes. In the first part of the study, researchers constructed images of faces using an Identikit that provided the features of hair, eyes, mouth, nose, and chin. Images were varied systematically. A series of these images, called exemplar…

  4. Eflornithine

    MedlinePlus

    ... is used to slow the growth of unwanted hair on the face in women, usually around the lips or under the chin. Eflornithine works by blocking a natural substance that is needed for hair to grow and is located in your hair ...

  5. Fundreds in Arkansas: An Interdisciplinary Collaboration

    ERIC Educational Resources Information Center

    La Porte, Angela M.

    2010-01-01

    This article discusses Fundreds in Arkansas, an interactive cooperative in Arkansas to promote and support Mel Chin's nationwide interdisciplinary artwork, Operation Paydirt (The Fundred Dollar Bill Project). The artwork involves communities and educational institutions across the country, healthcare professionals, engineers, urban planners, and…

  6. Quantum kung fu

    NASA Astrophysics Data System (ADS)

    Flicker, Felix

    2014-07-01

    If someone puts you in an armlock, what should you do? If you happen to be a martial artist well-practised in the art of joint manipulation, or chin na, you will know the answer already: there is one simple move that will allow you to turn the tables on your aggressor, leaving them on the wrong end of a throw.

  7. Facial Feature Extraction Based on Wavelet Transform

    NASA Astrophysics Data System (ADS)

    Hung, Nguyen Viet

    Facial feature extraction is one of the most important processes in face recognition, expression recognition and face detection. The aims of facial feature extraction are eye location, shape of eyes, eye brow, mouth, head boundary, face boundary, chin and so on. The purpose of this paper is to develop an automatic facial feature extraction system, which is able to identify the eye location, the detailed shape of eyes and mouth, chin and inner boundary from facial images. This system not only extracts the location information of the eyes, but also estimates four important points in each eye, which helps us to rebuild the eye shape. To model mouth shape, mouth extraction gives us both mouth location and two corners of mouth, top and bottom lips. From inner boundary we obtain and chin, we have face boundary. Based on wavelet features, we can reduce the noise from the input image and detect edge information. In order to extract eyes, mouth, inner boundary, we combine wavelet features and facial character to design these algorithms for finding midpoint, eye's coordinates, four important eye's points, mouth's coordinates, four important mouth's points, chin coordinate and then inner boundary. The developed system is tested on Yale Faces and Pedagogy student's faces.

  8. Swollen lymph nodes

    MedlinePlus

    ... fingers) include: Groin Armpit Neck (there is a chain of lymph nodes on either side of the front of the neck, both sides of the neck, and down each side of the back of the neck) Under the jaw and chin Behind the ears On the back of the head

  9. 77 FR 69498 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... or faxed comments should be submitted by December 4, 2012. Before including your address, phone.... ALABAMA Mobile County Africatown Historic District, Bounded by Jakes Ln., Paper Mill, & Warren Rds., Chin, & Railroad Sts., Mobile, 12000990 COLORADO Jefferson County Staunton Ranch Rural Historic Landscape,...

  10. Investigation of Primary Students' Motivation Levels towards Science Learning

    ERIC Educational Resources Information Center

    Sevinc, Betul; Ozmen, Haluk; Yigit, Nevzat

    2011-01-01

    The present research was conducted with 518 students enrolled at the 6th, 7th and 8th classes of primary schools. A likert-type scale developed by Tuan, Chin and Shieh (2005) and translated into Turkish by Yilmaz and Cavas (2007) was used to examine the motivation levels of students towards science learning. Research findings revealed that gender,…

  11. Papillary haemangioma: a case report of multiple facial location.

    PubMed

    Rammeh, S; Fazaa, B; Ajouli, W; Labbene, I; Kharfi, M; Zermani, R

    2014-06-01

    Papillary haemangiomas were recently defined as morphologically distinct and benign cutaneous haemangiomas showing a predominantly intravascular capillary proliferation within dilated thin-walled dermal blood vessels. We describe the case of a 45-year-old woman who presented with multiple eruptive red-bluish raised papules and nodules distributed over the skin of the chin that were related to a papillary haemangioma.

  12. A Modified Kole's Osteotomy for Correction of Anterior Open Bite and Macrogenia in a Cleft Patient.

    PubMed

    Ramanathan, Manikandhan; Rao, Srinivasan H

    2013-03-01

    We present a modified technique to close anterior open bite as well as to correct anterior and vertical macrogenia without sacrificing the lowermost symphyseal segment, in comparison with conventional Kole's osteotomy, which can alter the symmetric bone architecture of the chin and jeopardize the blood supply of the sandwich segments. PMID:24436737

  13. High-Resolution Global Modeling of the Effects of Subgrid-Scale Clouds and Turbulence on Precipitating Cloud Systems

    SciTech Connect

    Bogenschutz, Peter; Moeng, Chin-Hoh

    2015-10-13

    The PI’s at the National Center for Atmospheric Research (NCAR), Chin-Hoh Moeng and Peter Bogenschutz, have primarily focused their time on the implementation of the Simplified-Higher Order Turbulence Closure (SHOC; Bogenschutz and Krueger 2013) to the Multi-scale Modeling Framework (MMF) global model and testing of SHOC on deep convective cloud regimes.

  14. 50 CFR Table 1a to Part 679 - Delivery Condition* and Product Codes

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... Throat, or isthmus, slit to allow blood to drain 03 Bled fish destined for fish meal (includes offsite.... Head removed, belly slit, viscera and most of backbone removed; fillets attached 37 Cheeks. Muscles on sides of head (ancillary only) 17 Chins. Lower jaw (mandible), muscles, and flesh (ancillary only)...

  15. 50 CFR Table 1a to Part 679 - Delivery Condition and Product Codes

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Bled only. Throat or isthmus slit to allow blood to drain. 03 Bled fish destined for fish meal... Cheeks. Muscles on sides of head (ancillary only). 17 Chins. Lower jaw (mandible), muscles, and flesh... body behind head and in front of tail. 21 Fish meal. Meal from whole fish or fish parts; includes...

  16. 42 CFR 84.126 - Canister bench tests; minimum requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... hours. (b) Front-mounted and back-mounted gas mask canisters will be tested and shall meet the minimum... monoxide and particulate contaminants shall have a window or other indicator to warn the gas mask wearer... canister penetration has occurred. (d) Chin-style gas mask canisters shall meet the minimum...

  17. 42 CFR Appendix - Tables to Subpart I of Part 84

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirements for Front-Mounted and Back-Mounted Gas Mask Canisters Canister type Test condition Test atmosphere.... Table 6—Canister Bench Tests and Requirements for Chin-Style Gas Mask Canisters Canister type Test... will be 6 min instead of 12 min. Table 7—Canister Bench Tests and Requirements for Escape Gas...

  18. 42 CFR 84.126 - Canister bench tests; minimum requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... hours. (b) Front-mounted and back-mounted gas mask canisters will be tested and shall meet the minimum... monoxide and particulate contaminants shall have a window or other indicator to warn the gas mask wearer... canister penetration has occurred. (d) Chin-style gas mask canisters shall meet the minimum...

  19. 42 CFR 84.126 - Canister bench tests; minimum requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... hours. (b) Front-mounted and back-mounted gas mask canisters will be tested and shall meet the minimum... monoxide and particulate contaminants shall have a window or other indicator to warn the gas mask wearer... canister penetration has occurred. (d) Chin-style gas mask canisters shall meet the minimum...

  20. Visual fields and foraging in procellariiform seabirds: sensory aspects of dietary segregation.

    PubMed

    Martin, G R; Prince, P A

    2001-01-01

    Retinal visual fields were determined using an ophthalmoscopic reflex technique in two seabird species of the family Procellariidae: white-chinned petrel Procellaria aequinoctialis and antarctic prion Pachyptila desolata. The binocular fields of both species show a similar shape but they differ in size and in the position of the bill within the field. In white-chinned petrels the binocular field extends vertically through approximately 140 degrees and has a maximum width of approximately 40 degrees. The bill is placed approximately central within the field. The binocular field of the prions is approximately half this width and vertical extent, and the bill is placed close to the ventral edge. These differences in binocular field topography can be correlated with the different foraging techniques that these birds employ when seeking a similar diet within the same environment. White-chinned petrels pursue individual items both at the surface and while diving to moderate depths. Antarctic prions feed primarily by filtering items from surface waters. These differences in visual field topography mirror those found in different terrestrial bird species that primarily employ visual or tactile cues in the pursuit of food items. White-chinned petrel eyes and visual fields show features of an amphibious optical design similar to those found in penguins and albatrosses. PMID:11359046

  1. STS-53 Pilot Cabana adjusts CCA during JSC launch emergency egress training

    NASA Technical Reports Server (NTRS)

    1992-01-01

    STS-53 Discovery, Orbiter Vehicle (OV) 103, Pilot Robert D. Cabana, wearing launch and entry suit (LES), adjusts communications carrier assembly (CCA) chin strap and microphones before donning his helmet. Cabana is preparing for launch emergency egress bailout procedures in JSC's Mockup and Integration Laboratory (MAIL) Bldg 9NE.

  2. ["Microband F" extraoral traction appliance. Antero-posterior symmetry and asymmetry].

    PubMed

    Fotis, V; Basarelli, V

    1991-01-01

    The Authors describe a new appliance for monolateral asymmetric and/or bilateral symmetric extraoral anterior tractions. This new device doesn't need chin rest; it is specifically suggested for patients suffering from TMJ dysfunctions; from the esthetic point of view it is well accepted by patients.

  3. All Things in Moderation

    ERIC Educational Resources Information Center

    Malone, Larry; De Lucchi, Linda; Long, Kathy

    2004-01-01

    Four fourth-grade teachers are bent over a conference table, chins in palms, concentrating on one student's assessment paper. This paper is one of many on the table, organized into several ragged piles. The teachers are discussing nuances of the student's work, trying to reach agreement on the quality of the response. The goal of this careful…

  4. Revisiting the Authoritative-Dialogic Tension in Inquiry-Based Elementary Science Teacher Questioning

    ERIC Educational Resources Information Center

    Van Booven, Christopher D.

    2015-01-01

    Building on the "questioning-based discourse analytical" framework developed by Singapore-based science educator and discourse analyst, Christine Chin, this study investigated the extent to which fifth-grade science teachers' use of questions with either an authoritative or dialogic orientation differentially restricted or expanded the…

  5. 16 CFR 1203.15 - Positional stability test (roll-off resistance).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... dimensions of the full chin ISO reference headforms sizes A, E, J, M, and O. (2) Test fixture. The headform shall be secured in a test fixture with the headform's vertical axis pointing downward and 45 degrees to the direction of gravity (see Figure 7 of this part). The test fixture shall permit rotation of...

  6. 16 CFR 1203.15 - Positional stability test (roll-off resistance).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... dimensions of the full chin ISO reference headforms sizes A, E, J, M, and O. (2) Test fixture. The headform shall be secured in a test fixture with the headform's vertical axis pointing downward and 45 degrees to the direction of gravity (see Figure 7 of this part). The test fixture shall permit rotation of...

  7. 16 CFR 1203.15 - Positional stability test (roll-off resistance).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... dimensions of the full chin ISO reference headforms sizes A, E, J, M, and O. (2) Test fixture. The headform shall be secured in a test fixture with the headform's vertical axis pointing downward and 45 degrees to the direction of gravity (see Figure 7 of this part). The test fixture shall permit rotation of...

  8. 16 CFR 1203.15 - Positional stability test (roll-off resistance).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... dimensions of the full chin ISO reference headforms sizes A, E, J, M, and O. (2) Test fixture. The headform shall be secured in a test fixture with the headform's vertical axis pointing downward and 45 degrees to the direction of gravity (see Figure 7 of this part). The test fixture shall permit rotation of...

  9. Modified triaca-style wing osteotomy to correct facial asymmetry in a patient with horizontal growth-type condylar hyperplasia.

    PubMed

    Wenghoefer, Matthias; Peters, Armin; Reich, Rudolf Hermann

    2013-01-01

    In this short communication, we suggest a slight modification of Albino Triaca's chin-wing osteotomy to vertically correct the inferior border of the mandible in a patient with horizontal growth-type facial asymmetry due to condylar hyperplasia. PMID:24036777

  10. Gradient Shifts with Naturally Occurring Human Face Stimuli

    ERIC Educational Resources Information Center

    Derenne, Adam; Breitstein, R. Michael

    2006-01-01

    The present research examined stimulus generalization and gradient shifts on a dimension involving human faces. Twenty undergraduates were instructed to examine the proportion of the total face length that lay between the tip of the nose and the end of the chin. The face stimuli were images of actual people shown on a computer screen; no face was…

  11. An Emergent Curriculum in China: Collaborative Tolerance

    ERIC Educational Resources Information Center

    Farrell, Lynn

    2004-01-01

    The concept for the piloting of a contemporary early childhood kindergarten in China was visualised by the chief executive officer of TMC Academy, Dr Chin, in July 2002 when he participated in a Singaporean-led mission to Liaoning Province in China. Shenyang Creative Kindergarten is the result of that concept. It opened for children in September…

  12. Comparison of gene expression profiles in cultivated peanut (Arachis hypogaea) under strong artificial selection

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Over the past five decades, cultivated peanut in China has been subjected to strong artificial selection in breeding programs. To investigate the impact of artificial selection on expression diversity, we compared gene expression profiles in pod and leaf of five widespread cultivars in Southern Chin...

  13. Insecure Commitment and Resistance: An Examination of Change Leadership, Self-Efficacy, and Trust on the Relationship between Job Insecurity, Employee Commitment, and Resistance to Organizational Change

    ERIC Educational Resources Information Center

    Smith, Robert Elijah

    2013-01-01

    This study was designed to examine the mediation role of self-efficacy and the moderating roles of change leadership strategy and trust on the change attitudes of job insecure employees. Using job insecurity theory (Greenhalgh, 1983), Chin & Benne's (1961) seminal classification of change leadership strategies and the tripartite model of…

  14. English Teaching & Learning, 2002-2003.

    ERIC Educational Resources Information Center

    English Teaching & Learning, 2003

    2003-01-01

    These four issues contain the following articles: "A Case Documentation of English Instruction at the Elementary School Level: The Cross-Cultural Impact of Native Speaker Teachers" (Hsien-Chin Liou) [written in Chinese]; "A Collaborative Tale with Two Taiwanese EFL College Groups" (Feng-Ming Chi); "A Developmental Study on Phonological Awareness…

  15. feature - Office of Cancer Clinical Proteomics Research

    Cancer.gov

    "Cancer is a disease of the genome," noted Lynda Chin, M.D., professor of dermatology, Harvard Medical School and Dana-Farber Cancer Institute. "And understanding the impact of genomic changes in the proteome is critically important for converting genomic knowledge into something that a clinician can use on their patients."

  16. NITROTYROSINE ATTENUATES RSV-INDUCED INFLAMMATION IN AIRWAY EPITHELIAL CELLS

    EPA Science Inventory

    Nitrotyrosine attenuates RSV-induced inflammation in airway epithelial cells. Joleen Soukup, Zuowei Li, Susanne Becker and Yuh-Chin Huang. NHEERL, ORD, USEPA, RTP, North Carolina, CEMALB, University of North Carolina, Chapel Hill, North Carolina

    Nitrotyrosine (NO2Tyr) is a...

  17. Congenital Heart Information Network

    MedlinePlus

    ... Barmash and Uwe Baemayr for The Congenital Heart Information Network Exempt organization under Section 501(c)3. Copyright ©1996 - 2016 C.H.I.N. All rights reserved TX4-390-685 Original site design and HTML by Panoptic Communications

  18. 42 CFR 84.1130 - Respirators; description.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... respective vapors, or from the chemical reaction between their respective vapors and gases. (3) Air-purifying... reaction with sorbent material in the canister. (c) Pesticide respirators, including all completely...) Front-mounted or back-mounted gas masks; (2) Chin-style gas mask; (3) Chemical cartridge; (4)...

  19. 42 CFR 84.1130 - Respirators; description.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... respective vapors, or from the chemical reaction between their respective vapors and gases. (3) Air-purifying... reaction with sorbent material in the canister. (c) Pesticide respirators, including all completely...) Front-mounted or back-mounted gas masks; (2) Chin-style gas mask; (3) Chemical cartridge; (4)...

  20. 42 CFR 84.1130 - Respirators; description.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... respective vapors, or from the chemical reaction between their respective vapors and gases. (3) Air-purifying... reaction with sorbent material in the canister. (c) Pesticide respirators, including all completely...) Front-mounted or back-mounted gas masks; (2) Chin-style gas mask; (3) Chemical cartridge; (4)...

  1. 42 CFR 84.1130 - Respirators; description.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... respective vapors, or from the chemical reaction between their respective vapors and gases. (3) Air-purifying... reaction with sorbent material in the canister. (c) Pesticide respirators, including all completely...) Front-mounted or back-mounted gas masks; (2) Chin-style gas mask; (3) Chemical cartridge; (4)...

  2. 42 CFR 84.1130 - Respirators; description.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... respective vapors, or from the chemical reaction between their respective vapors and gases. (3) Air-purifying... reaction with sorbent material in the canister. (c) Pesticide respirators, including all completely...) Front-mounted or back-mounted gas masks; (2) Chin-style gas mask; (3) Chemical cartridge; (4)...

  3. VANADL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF ENOS

    EPA Science Inventory

    VANADYL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF eNOS. Zhuowei Li, Jacqueline D. Carter, Lisa A. Dailey, Joleen Soukup, Yuh-Chin T. Huang. CEMALB, University of North Carolina and ORD, US EPA, Chapel Hill, North Carolina
    V...

  4. URBAN PARTICLE-INDUCED PULMONARY ARTERY CONSTRUCTION IS MEDIATED BY SUPEROXIDE PRODUCTION

    EPA Science Inventory

    URBAN PARTICLE-INDUCED PULMONARY ARTERY CONSTRICTION IS MEDIATED BY SUPEROXIDE PRODUCTION.Jacqueline D. Carter, Zhuowei Li, Lisa A. Dailey, Yuh-Chin T. Huang. CEMALB, University of North Carolina, and ORD, US EPA, Chapel Hill, North Carolina.

    Exposure to particulate matter...

  5. VANADYL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF ENOS

    EPA Science Inventory

    VANADYL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF eNOS.

    Zhuowei Li, Jacqueline D. Carter, Lisa A. Dailey, Joleen Soukup, Yuh-Chin T. Huang. CEMALB, University of North Carolina and NHEERL, US EPA, Chapel Hill, North Ca...

  6. Interorganizational health care systems implementations: an exploratory study of early electronic commerce initiatives.

    PubMed

    Payton, F C; Ginzberg, M J

    2001-01-01

    Changing business practices, customers needs, and market dynamics have driven many organizations to implement interorganizational systems (IOSs). IOSs have been successfully implemented in the banking, cotton, airline, and consumer-goods industries, and recently attention has turned to the health care industry. This article describes an exploratory study of health care IOS implementations based on the voluntary community health information network (CHIN) model.

  7. Visual fields and foraging in procellariiform seabirds: sensory aspects of dietary segregation.

    PubMed

    Martin, G R; Prince, P A

    2001-01-01

    Retinal visual fields were determined using an ophthalmoscopic reflex technique in two seabird species of the family Procellariidae: white-chinned petrel Procellaria aequinoctialis and antarctic prion Pachyptila desolata. The binocular fields of both species show a similar shape but they differ in size and in the position of the bill within the field. In white-chinned petrels the binocular field extends vertically through approximately 140 degrees and has a maximum width of approximately 40 degrees. The bill is placed approximately central within the field. The binocular field of the prions is approximately half this width and vertical extent, and the bill is placed close to the ventral edge. These differences in binocular field topography can be correlated with the different foraging techniques that these birds employ when seeking a similar diet within the same environment. White-chinned petrels pursue individual items both at the surface and while diving to moderate depths. Antarctic prions feed primarily by filtering items from surface waters. These differences in visual field topography mirror those found in different terrestrial bird species that primarily employ visual or tactile cues in the pursuit of food items. White-chinned petrel eyes and visual fields show features of an amphibious optical design similar to those found in penguins and albatrosses.

  8. Toward a Paradigm of Educational Change: The Role of Management Information Systems.

    ERIC Educational Resources Information Center

    Simonds, Richard Shelton

    The paradigm and model presented in this paper, influenced by the Havelock's "linkage" model and Chin's "changing" model, aim to assist educators in determing directions of change using a selection of managerial and behavioral techniques, and to regulate the rate of change using management information and control systems. The generic paradigm…

  9. ALTERATION OF CARDIAC ELECTRICAL ACTIVITY BY WATER-LEACHABLE COMPONENTS OF RESIDUAL OIL FLY ASH (ROFA)

    EPA Science Inventory

    Alteration of cardiac electrical activity by water-leachable components
    of residual oil fly ash (ROFA)

    Desuo Wang, Yuh-Chin T. Huang*, An Xie, Ting Wang

    *Human Studies Division, NHEERL, US EPA
    104 Mason Farm Road, Chapel Hill, NC 27599
    Department of Basic ...

  10. 1. Historic American Buildings Survey E. W. Russell, Photographer, February ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey E. W. Russell, Photographer, February 6, 1936 WROUGHT IRON GATE WITH CAST IRON ORNAMENTATION, 456 SO. CONCEPTION STREET - 456 South Conception Street (Iron Fence & Gate), (moved to 1802 Old Govt. & 3333 Riviere du Chin), Mobile, Mobile County, AL

  11. EFFECTS OF METAL COMPONENTS IN CONCENTRATED AMBIENT AIR PARTICLES ON PULMONARY INJURY

    EPA Science Inventory

    EFFECTS OF METAL COMPONENTS IN CONCENTRATED AMBIENT AIR PARTICLES ON PULMONARY INJURY. Yuh-Chin Huang, Jackie Stonehuerner, Jackie Carter, Andrew J. Ghio, Robert B. Devlin. NHEERL, US EPA, RTP, NC.
    The mechanisms for cardiopulmonary morbidity associated with exposure to air po...

  12. Pedagogy Journal, 1996.

    ERIC Educational Resources Information Center

    Marashio Paul, Ed.; And Others

    1996-01-01

    This annual serial volume contains 19 articles offering practical pedagogical ideas from faculty at New Hampshire technical colleges. The following articles are presented: (1) "Goodbye Mr. Desrochers or What I Learned While Teaching My First Lit. Course," by Diane Chin; (2) "A Teacher Learns: Building a Fly Rod," by Walter Ryan; (3) "A Teacher in…

  13. Descriptions of four species of grenadier fishes of the genera Hymenocephalus and Hymenogadus (Teleostei, Gadiformes, Macrouridae) from the New Zealand region and Tasman Sea, including two new species of Hymenocephalus.

    PubMed

    McMillan, Peter; Iwamoto, Tomio

    2014-01-01

    Two new species of Hymenocephalus are described from the New Zealand region and Tasman Sea. Hymenocephalus fuscus sp. n. has 11-12 pelvic fin rays, is darkly pigmented, with enlarged bony ridges on the dorsal aspects of head, lacks a chin barbel, has few (16-19) gill rakers on inner side of first arch and is similar to other species in the H. aterrimus species group. Hymenocephalus maculicaudus sp. n. has 8 pelvic fin rays, a mid-lateral line of melanophores on body and tail that extends about a head length posterior to anal fin origin, a short (7-16 % HL) chin barbel and is similar to other species in the H. megalops species group. Hymenocephalus nascens has 12-14 pelvic fin rays, lacks a chin barbel, has a mid-lateral stripe of silvery (fresh) or brownish (preserved) pigment running along trunk and tail. Hymenogadus gracilis has a serrated (weak, near tip) first dorsal fin spine, 7-9 pelvic fin rays, long (20-30% HL) chin barbel, and one row of enlarged melanophores along lateral mid-line of the tail. Hymenocephalus nascens and Hymenogadus gracilis are recorded for the first time from the New Zealand region. A key to the known New Zealand species of Hymenocephalus and Hymenogadus is provided.  PMID:25284648

  14. Temporomandibular joint dislocation and deafness from a cricket ball injury.

    PubMed

    Murthy, P; Bandasson, C; Dhillon, R S

    1994-05-01

    Cricket is a national sport in some countries and can be potentially hazardous. We report an incident of a cricket ball impact to the chin, which resulted in posterior dislocation of both temporomandibular joints and bilateral mixed deafness. There appear to be no similar case reports in the literature.

  15. Outline of the beginnings of alchemy and its antecedents.

    PubMed

    Mahdihassan, S

    1984-01-01

    There had been a long use of Simples as drugs of longevity. Among these red substances predominated, red ochre and cinnabar as minerals, ephedra bearing red berries and pomegranate and peach as vegetable products. In China herbalism became a cult of longevity with its legendary founder as Emperor Shen Nung and with the god of longevity finally emerging from the peach as Shou-Sing. To excell simple drugs of longevity the first synthetic drug was prepared as brick red colloidal gold. It was called Chin-I. Gold-cum-herbal juice. Dialectally it was pronounced Kim-Iya, whence Alkimiya in Arabic, and finally alchemy. Chin-I was Herbo-golden drug and also gold-making-juice, a miraculous substance. But it was not blood-red. Now came Chin-Tan, Cinnabar-gold, red like blood. Its redness equalled blood and as such was soul, gold as its acceptor had an everlasting body. Chin-Tan was designed as the ideal drug of longevity. Alchemy started by making red gold but degenerated, trying to make bullion gold.

  16. Periodontal Side Effect During Orthopedic Face Mask Therapy.

    PubMed

    Incerti-Parenti, Serena; Checchi, Vittorio; Molinari, Camilla; Alessandri-Bonetti, Giulio

    2015-01-01

    A 7-year-old patient exhibited gingival recession of tooth #41 and severe plaque accumulation after 3 months of face mask therapy. The recession improved only slightly after appropriate oral hygiene instructions and motivation. Decisive improvement began when the vertical chin pad extension was reduced to avoid pressure on the affected area. PMID:27029093

  17. Studies Presented to Robert B. Lees by His Students. Papers in Linguistics.

    ERIC Educational Resources Information Center

    Sadock, Jerrold M.; Vanek, Anthony L.

    This volume, dedicated to Professor Robert B. Lees on the occasion of his departure from the University of Illinois, contains 15 papers on a variety of linguistic topics: C. L. Baker, "Problems of Polarity in Counterfactuals"; Lawrence F. Bouton, "Do So: Do+Adverb"; Chin-chuan Cheng, "Domains of Phonological Rule Application"; Joseph F. Foster,…

  18. Tracking Speech Sound Acquisition

    ERIC Educational Resources Information Center

    Powell, Thomas W.

    2011-01-01

    This article describes a procedure to aid in the clinical appraisal of child speech. The approach, based on the work by Dinnsen, Chin, Elbert, and Powell (1990; Some constraints on functionally disordered phonologies: Phonetic inventories and phonotactics. "Journal of Speech and Hearing Research", 33, 28-37), uses a railway idiom to track gains in…

  19. NITROTYROSINATION OF A TUBULIN INDUCES EPITHELIAL BARRIER DYSFUNCTION

    EPA Science Inventory

    Nitrotyrosination of a-Tubulin Induces Epithelial Transport Dysfunction. Yuh-Chin Huang, Lisa Dailey, Wen-Li Zhang and Ilona Jaspers. ORD, Environmental Protection Agency and CEMLB, University of North Carolina

    a-Tubulin undergoes a cyclic removal and readdition of tyrosin...

  20. Descriptions of four species of grenadier fishes of the genera Hymenocephalus and Hymenogadus (Teleostei, Gadiformes, Macrouridae) from the New Zealand region and Tasman Sea, including two new species of Hymenocephalus.

    PubMed

    McMillan, Peter; Iwamoto, Tomio

    2014-08-21

    Two new species of Hymenocephalus are described from the New Zealand region and Tasman Sea. Hymenocephalus fuscus sp. n. has 11-12 pelvic fin rays, is darkly pigmented, with enlarged bony ridges on the dorsal aspects of head, lacks a chin barbel, has few (16-19) gill rakers on inner side of first arch and is similar to other species in the H. aterrimus species group. Hymenocephalus maculicaudus sp. n. has 8 pelvic fin rays, a mid-lateral line of melanophores on body and tail that extends about a head length posterior to anal fin origin, a short (7-16 % HL) chin barbel and is similar to other species in the H. megalops species group. Hymenocephalus nascens has 12-14 pelvic fin rays, lacks a chin barbel, has a mid-lateral stripe of silvery (fresh) or brownish (preserved) pigment running along trunk and tail. Hymenogadus gracilis has a serrated (weak, near tip) first dorsal fin spine, 7-9 pelvic fin rays, long (20-30% HL) chin barbel, and one row of enlarged melanophores along lateral mid-line of the tail. Hymenocephalus nascens and Hymenogadus gracilis are recorded for the first time from the New Zealand region. A key to the known New Zealand species of Hymenocephalus and Hymenogadus is provided. 

  1. International Symposium on Chinese Languages and Linguistics Proceedings (4th, Taipei, Taiwan, July 18-20, 1994).

    ERIC Educational Resources Information Center

    Ho, Dah-an, Ed.; Tseng, Chiu-yu, Ed.

    This publication of proceedings, most in English and some in Chinese, of a conference on Chinese languages and linguistics include the following papers: "On Rule Effect and Dialect Classification" (Chin-Chuan Cheng); "Cross-Linguistic Typological Variation, Grammatical Relations, and the Chinese Language" (Bernard Comrie); "Is Chinese a Pragmatic…

  2. Comment on 'Quantum teleportation of an arbitrary two-qubit state and its relation to multipartite entanglement'

    SciTech Connect

    Deng Fuguo

    2005-09-15

    The multipartite state in the Rigolin's protocol [Phys. Rev. A 71, 032303 (2005)] for teleporting an arbitrary two-qubit state is just a product state of N Einstein-Podolsky-Rosen pairs in essence, not a genuine multipartite entangled state, and this protocol in principle is equivalent to the Yang-Guo protocol [Chin. Phys. Lett. 17, 162 (2000)].

  3. Can longer forest harvest intervals increase summer streamflow for salmon recovery?

    EPA Science Inventory

    The Mashel Streamflow Modeling Project in the Mashel River Basin, Washington, is using a watershed-scale ecohydrological model to assess whether longer forest harvest intervals can remediate summer low flow conditions that have contributed to sharply reduced runs of spawning Chin...

  4. Factor Structure of the Multidimensional Orientation toward Dying and Death Inventory among Hong Kong College Students: A Preliminary Study

    ERIC Educational Resources Information Center

    Wittkowski, Joachim; Ho, Samuel M. Y.; Chan, Wallace C. H.

    2011-01-01

    This study examines the factor structures of the Chinese version of the Multidimensional Orientation Toward Dying and Death Inventory (MODDI-F/chin), originally established in German language, in a sample of Hong Kong college students (n = 256). Both confirmatory factor analysis and exploratory factor analysis were performed to examine the factor…

  5. Movement Activity Levels on Traditional and Contemporary Playground Structures.

    ERIC Educational Resources Information Center

    Gabbard, Carl P.; LeBlanc, Elizabeth

    This study investigated playground activity levels of children in grades K-4 and compared levels of use of traditional and creative playground apparatus. The traditional playground area consisted of climbing bars, slides, ladders, chin bars, swings, see saws, and a merry-go-round. The creative playground contained tire hurdles, tire walk, tire…

  6. A Modified Kole's Osteotomy for Correction of Anterior Open Bite and Macrogenia in a Cleft Patient.

    PubMed

    Ramanathan, Manikandhan; Rao, Srinivasan H

    2013-03-01

    We present a modified technique to close anterior open bite as well as to correct anterior and vertical macrogenia without sacrificing the lowermost symphyseal segment, in comparison with conventional Kole's osteotomy, which can alter the symmetric bone architecture of the chin and jeopardize the blood supply of the sandwich segments.

  7. The Grapefruit Race: Demonstrating the Influence of Competition on Gender Differences in Intimacy

    ERIC Educational Resources Information Center

    Hebl, Mikki R.; King, Eden B.; McGuire, Julie; Turchin, Melissa

    2008-01-01

    We present an interactive demonstration of factors that mitigate gender differences. Male and female volunteers pass a grapefruit from one classmate to the next using only their chins. The speed of task completion depends on its framing; when the volunteers believe the task is an exercise, women tend to be faster than men, whereas the opposite…

  8. Identification of Physically Underdeveloped Pupils: Activities to Improve Their Performance.

    ERIC Educational Resources Information Center

    President's Council on Physical Fitness and Sports, Washington, DC.

    Screening tests consisting of observation procedures and simple physical exercises requiring only a chinning bar, stopwatch, and record forms are suggested for identifying pupils aged ten to seventeen who are underdeveloped in strength, flexibility, agility, or cardiorespiratory endurance. Classes should be divided into pairs with one pupil acting…

  9. Outline of the beginnings of alchemy and its antecedents.

    PubMed

    Mahdihassan, S

    1984-01-01

    There had been a long use of Simples as drugs of longevity. Among these red substances predominated, red ochre and cinnabar as minerals, ephedra bearing red berries and pomegranate and peach as vegetable products. In China herbalism became a cult of longevity with its legendary founder as Emperor Shen Nung and with the god of longevity finally emerging from the peach as Shou-Sing. To excell simple drugs of longevity the first synthetic drug was prepared as brick red colloidal gold. It was called Chin-I. Gold-cum-herbal juice. Dialectally it was pronounced Kim-Iya, whence Alkimiya in Arabic, and finally alchemy. Chin-I was Herbo-golden drug and also gold-making-juice, a miraculous substance. But it was not blood-red. Now came Chin-Tan, Cinnabar-gold, red like blood. Its redness equalled blood and as such was soul, gold as its acceptor had an everlasting body. Chin-Tan was designed as the ideal drug of longevity. Alchemy started by making red gold but degenerated, trying to make bullion gold. PMID:6388307

  10. Are We Ready to #MeetTheMoment?

    ERIC Educational Resources Information Center

    Chin, Maisie

    2015-01-01

    CADRE, an organization led by Maisie Chin, is a Human Right to Education Campaign. Between 2005 and 2013, CADRE played a lead role in using grassroots organizing and leadership development to create a seismic shift in public policy, debate, and narrative around school discipline, racial disparities, parents' roles, school climate, and closing the…

  11. Adaptation of the Students' Motivation towards Science Learning (SMTSL) Questionnaire in the Greek Language

    ERIC Educational Resources Information Center

    Dermitzaki, Irini; Stavroussi, Panayiota; Vavougios, Denis; Kotsis, Konstantinos T.

    2013-01-01

    The present study aimed at adapting in the Greek language the Students' Motivation Towards Science Learning (SMTSL) questionnaire developed by Tuan, Chin, and Shieh ("INT J SCI EDUC" 27(6): 639-654, 2005a) into a different cultural context, a different age group, that is, in university students and with a focus on physics learning.…

  12. A Randomized Study of Three Interventions for Aspiration of Thin Liquids in Patients with Dementia or Parkinson's Disease

    ERIC Educational Resources Information Center

    Logemann, Jeri A.; Gensler, Gary; Robbins, JoAnne; Lindblad, Anne S.; Brandt, Diane; Hind, Jacqueline A.; Kosek, Steven; Dikeman, Karen; Kazandjian, Marta; Gramigna, Gary D.; Lundy, Donna; McGarvey-Toler, Susan; Miller Gardner, Patricia J.

    2008-01-01

    Purpose: This study was designed to identify which of 3 treatments for aspiration on thin liquids--chin-down posture, nectar-thickened liquids, or honey-thickened liquids--results in the most successful immediate elimination of aspiration on thin liquids during the videofluorographic swallow study in patients with dementia and/or Parkinson's…

  13. Acrocallosal syndrome: report of a Brazilian girl.

    PubMed

    Guion-Almeida, M L; Richieri-Costa, A

    1992-08-01

    We report on a Brazilian girl born to nonconsanguineous parents and presenting with frontonasal dysostosis, callosal agenesis, abnormal upper lids, cleft lip/palate, redundant skin in the neck, grooved chin, and bifid thumbs. Major diagnostic criteria present in this patient are related to the acrocallosal syndrome. The clinical and major nosologic aspects of this condition are discussed.

  14. Photographic Facial Soft Tissue Analysis by Means of Linear and Angular Measurements in an Adolescent Persian Population

    PubMed Central

    Moshkelgosha, Vahid; Fathinejad, Sheida; Pakizeh, Zeinab; Shamsa, Mohammad; Golkari, Ali

    2015-01-01

    Objective : To obtain objective average measurements of the profile and frontal facial soft tissue to be used as a guide for aesthetic treatment goals. Methods and Materials : This observational study included 110 females and 130 males high school students aged 16-18 years. None of the subjects had any facial deformities. All of them and their parents gave consent to take part in this study. In each case, two standard photographs of profile and frontal views were taken 27 landmarks were digitized on photographs. The mean, standard deviation, and range for a total of 43 facial indices were calculated digitally by computer software. The Student’s t-test was used to compare males and females. Results : The ratio between the lower and middle facial thirds was one to one, but the height of the upper facial third was proportionally smaller than the other two-thirds in both sexes. Boys had greater nasal length, depth, and prominence than girls with statistically significant differences. Both upper and lower lips were more prominent in girls than in boys. All measurements of the chin showed sexual dimorphism characterized by greater chin height and prominence and deeper mentolabial sulcus. Boys had greater facial dimensions than girls. Mouth width, nasal base width, and intercanthal distance were significantly greater in boys. Conclusion : The labial, nasal, and chin areas showed sexual dimorphism in most of the parameters used in this study. Boys had larger faces, greater facial heights, longer nasal, labial, and chin lengths, and greater nasal, labial, and chin prominence. PMID:26464606

  15. Brain activity varies with modulation of dynamic pitch variance in sentence melody.

    PubMed

    Meyer, Martin; Steinhauer, Karsten; Alter, Kai; Friederici, Angela D; von Cramon, D Yves

    2004-05-01

    Fourteen native speakers of German heard normal sentences, sentences which were either lacking dynamic pitch variation (flattened speech), or comprised of intonation contour exclusively (degraded speech). Participants were to listen carefully to the sentences and to perform a rehearsal task. Passive listening to flattened speech compared to normal speech produced strong brain responses in right cortical areas, particularly in the posterior superior temporal gyrus (pSTG). Passive listening to degraded speech compared to either normal or flattened speech particularly involved fronto-opercular and subcortical (Putamen, Caudate Nucleus) regions bilaterally. Additionally the Rolandic operculum (premotor cortex) in the right hemisphere subserved processing of neat sentence intonation. As a function of explicit rehearsing sentence intonation we found several activation foci in the left inferior frontal gyrus (Broca's area), the left inferior precentral sulcus, and the left Rolandic fissure. The data allow several suggestions: First, both flattened and degraded speech evoked differential brain responses in the pSTG, particularly in the planum temporale (PT) bilaterally indicating that this region mediates integration of slowly and rapidly changing acoustic cues during comprehension of spoken language. Second, the bilateral circuit active whilst participants receive degraded speech reflects general effort allocation. Third, the differential finding for passive perception and explicit rehearsal of intonation contour suggests a right fronto-lateral network for processing and a left fronto-lateral network for producing prosodic information. Finally, it appears that brain areas which subserve speech (frontal operculum) and premotor functions (Rolandic operculum) coincidently support the processing of intonation contour in spoken sentence comprehension.

  16. Brain activity varies with modulation of dynamic pitch variance in sentence melody.

    PubMed

    Meyer, Martin; Steinhauer, Karsten; Alter, Kai; Friederici, Angela D; von Cramon, D Yves

    2004-05-01

    Fourteen native speakers of German heard normal sentences, sentences which were either lacking dynamic pitch variation (flattened speech), or comprised of intonation contour exclusively (degraded speech). Participants were to listen carefully to the sentences and to perform a rehearsal task. Passive listening to flattened speech compared to normal speech produced strong brain responses in right cortical areas, particularly in the posterior superior temporal gyrus (pSTG). Passive listening to degraded speech compared to either normal or flattened speech particularly involved fronto-opercular and subcortical (Putamen, Caudate Nucleus) regions bilaterally. Additionally the Rolandic operculum (premotor cortex) in the right hemisphere subserved processing of neat sentence intonation. As a function of explicit rehearsing sentence intonation we found several activation foci in the left inferior frontal gyrus (Broca's area), the left inferior precentral sulcus, and the left Rolandic fissure. The data allow several suggestions: First, both flattened and degraded speech evoked differential brain responses in the pSTG, particularly in the planum temporale (PT) bilaterally indicating that this region mediates integration of slowly and rapidly changing acoustic cues during comprehension of spoken language. Second, the bilateral circuit active whilst participants receive degraded speech reflects general effort allocation. Third, the differential finding for passive perception and explicit rehearsal of intonation contour suggests a right fronto-lateral network for processing and a left fronto-lateral network for producing prosodic information. Finally, it appears that brain areas which subserve speech (frontal operculum) and premotor functions (Rolandic operculum) coincidently support the processing of intonation contour in spoken sentence comprehension. PMID:15068910

  17. Who Pioneered the Use of Antipsychotics in North America?

    PubMed Central

    Stip, Emmanuel

    2015-01-01

    Objective: Neuroleptics were introduced into North America 60 years ago. The credit for this advance is generally accorded to Heinz Lehmann. I sought to explore whether Lehmann really was the first North American psychiatrist to study the effects of chlorpromazine (CPZ) and to provide a more balanced view of its application in a clinical context. Method: I searched for historical documents and published articles in several libraries and interviewed psychiatrists active from 1952–1970. Results: The first article in English was published in the July volume of the Archives of Neurology and Psychiatry in 1954 (n = 71). Another article, written in French by Roland Saucier and published in a journal called Le Saguenay Médical, also described the effects of CPZ on a Canadian psychiatric population in August 1954 (n > 200). However, the first prescription for CPZ was written by Roland Saucier, who brought the product back from Paris after a fellowship there. Ruth Kajander, in Ontario, was also one of the first prescribers of this drug, following her study of its use in anesthesia and a publication in the proceedings of a symposium. Conclusion: The contents of the 2 naturalistic studies were compared. Lehmann’s study started 1 month before that of Saucier. Lehmann was the first North American psychiatrist to publish an article on CPZ, but Roland Saucier nevertheless made an important contribution, being the first to prescribe this drug in North America and reporting results for a study with a sample size 3 times that of Lehmann’s study. PMID:25886681

  18. Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: the continuing debate.

    PubMed

    Deonna, Thierry; Roulet-Perez, Eliane

    2010-10-01

    Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome) may present as a developmental language disturbance and the affected child may also exhibit autistic features. Landau-Kleffner is now seen as the rare and severe end of a spectrum of cognitive-behavioural symptoms that can be seen in idiopathic (genetic) focal epilepsies of childhood, the benign end being the more frequent typical rolandic epilepsy. Several recent studies show that many children with rolandic epilepsy have minor developmental cognitive and behavioural problems and that some undergo a deterioration (usually temporary) in these domains, the so-called "atypical" forms of the syndrome. The severity and type of deterioration correlate with the site and spread of the epileptic spikes recorded on the electroencephalogram within the perisylvian region, and continuous spike-waves during sleep (CSWS) frequently occur during this period of the epileptic disorder. Some of these children have more severe preexisting communicative and language developmental disorders. If early stagnation or regression occurs in these domains, it presumably reflects epileptic activity in networks outside the perisylvian area, i.e. those involved in social cognition and emotions. Longitudinal studies will be necessary to find out if and how much the bioelectrical abnormalities play a causal role in these subgroup of children with both various degrees of language and autistic regression and features of idiopathic focal epilepsy. One has to remember that it took nearly 40 years to fully acknowledge the epileptic origin of aphasia in Landau-Kleffner syndrome and the milder acquired cognitive problems in rolandic epilepsies.

  19. Molecules and Clusters in Intense Laser Fields

    NASA Astrophysics Data System (ADS)

    Posthumus, Jan

    2001-06-01

    Preface; 1. Ultra-high intensity based on Ti:Sapphire Philip F. Taday and Andrew J. Langley; 2. Diatomic molecules in intense laser fields Jan H. Posthumus and James F. McCann; 3. Small polyatomic molecules in intense laser fields C. Cornaggia; 4. Coherent control in intense laser fields Eric Charron and Brian Sheehy; 5. Experimental studies of laser-heated rare gas clusters M. Lezius and M. Schmidt; 6. Single cluster explosions and high harmonic generation John W. G. Tisch and Emma Springate; 7. Intense laser interaction with extended cluster media Roland A. Smith and Todd Ditmire.

  20. Molecules and Clusters in Intense Laser Fields

    NASA Astrophysics Data System (ADS)

    Posthumus, Jan

    2009-09-01

    Preface; 1. Ultra-high intensity based on Ti:Sapphire Philip F. Taday and Andrew J. Langley; 2. Diatomic molecules in intense laser fields Jan H. Posthumus and James F. McCann; 3. Small polyatomic molecules in intense laser fields C. Cornaggia; 4. Coherent control in intense laser fields Eric Charron and Brian Sheehy; 5. Experimental studies of laser-heated rare gas clusters M. Lezius and M. Schmidt; 6. Single cluster explosions and high harmonic generation John W. G. Tisch and Emma Springate; 7. Intense laser interaction with extended cluster media Roland A. Smith and Todd Ditmire.

  1. Air resistance measurements on actual airplane parts

    NASA Technical Reports Server (NTRS)

    Weiselsberger, C

    1923-01-01

    For the calculation of the parasite resistance of an airplane, a knowledge of the resistance of the individual structural and accessory parts is necessary. The most reliable basis for this is given by tests with actual airplane parts at airspeeds which occur in practice. The data given here relate to the landing gear of a Siemanms-Schuckert DI airplane; the landing gear of a 'Luftfahrzeug-Gesellschaft' airplane (type Roland Dlla); landing gear of a 'Flugzeugbau Friedrichshafen' G airplane; a machine gun, and the exhaust manifold of a 269 HP engine.

  2. Evaluation of Clear Sky Models for Satellite-Based Irradiance Estimates

    SciTech Connect

    Sengupta, M.; Gotseff, P.

    2013-12-01

    This report describes an intercomparison of three popular broadband clear sky solar irradiance model results with measured data, as well as satellite-based model clear sky results compared to measured clear sky data. The authors conclude that one of the popular clear sky models (the Bird clear sky model developed by Richard Bird and Roland Hulstrom) could serve as a more accurate replacement for current satellite-model clear sky estimations. Additionally, the analysis of the model results with respect to model input parameters indicates that rather than climatological, annual, or monthly mean input data, higher-time-resolution input parameters improve the general clear sky model performance.

  3. On the nature of the anti-tail of Comet Kohoutek /1973f/. I - A working model

    NASA Technical Reports Server (NTRS)

    Sekanina, Z.

    1974-01-01

    The model derived for the anti-tail of Comet Kohoutek describes it as a flat formation, confined essentially to the comet's orbit plane and composed of relatively heavy particles (mostly in the size range 0.1-1 mm) whose motions are controlled by solar gravity and solar radiation pressure. Almost all the material was produced by the comet before perihelion at a rate about an order of magnitude higher than for Comets Arend-Roland and Bennett. The latent heat of vaporization of the particle material is estimated at 40-45 kcal/mole or higher.

  4. Migraine and the benign partial epilepsies of childhood: evidence for an association.

    PubMed

    Andermann, F

    2000-01-01

    There is an increasing body of evidence to suggest that benign rolandic epilepsy and benign occipital epilepsy of childhood are frequently associated with migraine. This however has not been universally recognized. Clearly further investigation of this association is required. The purpose of this report is to examine the varied diagnostic criteria for common migraine utilized by epileptologists and other neurologists, to review clinical migraine epilepsy relationships, EEG abnormalities in migraine and epilepsy, and the association of seizures with vascular headache in patients with various forms of epilepsy. Hopefully, this will stimulate further research into this intriguing association of two conditions which though they have different pathophysiology frequently coexist.

  5. Astronomy-Connected Scientific Works in Early Transylvania and Banat

    NASA Astrophysics Data System (ADS)

    Farkas, Ladislau

    2008-09-01

    Baron Roland von Eötvös: physicist who demonstrated the proportionality of the inertial and gravitational mass and carried out research on the spatial changes in gravitation. Some of his experiments was made on the territory of Banat and Crisana (south-easter Transylvania). Count Luigi Ferdinando Marsigli: a very complex personality: engineer, diplomat, spy, scientist (geograph, historian, biologist, astronomer), who made the first astronomical observations in Banat and published them. Maximilian Hell: a mathematician and astronomer who founded the first astronomical observatory in Cluj and made observations on a very interesting natural phenomenon: the transit of the planet Venus.

  6. [Recommendations for a basic functional assessment of low back pain].

    PubMed

    Demoulin, C; Fauconnier, C; Vanderthommen, M; Henrotin, Y

    2005-01-01

    This article aims to recommend easy, reproducible and valid physical tests and questionnaires to allow a functional and physical assessment of sub-acute and chronic low back pain patients. We recommend the pain visual analogue scale, the French translation of the Roland-Morris Disability Questionnaire (EIFEL) and the Dallas questionnaire to appreciate pain intensity and its influence on patients' quality of life. Sorensen's test is recommended in order to assess trunk extensor muscles endurance. We suggest to measure pelvic and lumbar flexion mobility by means of the inclinometer technique. The test described by McQuade is recommended to assess abdominal muscles static endurance. PMID:16184742

  7. Migraine and the benign partial epilepsies of childhood: evidence for an association.

    PubMed

    Andermann, F

    2000-01-01

    There is an increasing body of evidence to suggest that benign rolandic epilepsy and benign occipital epilepsy of childhood are frequently associated with migraine. This however has not been universally recognized. Clearly further investigation of this association is required. The purpose of this report is to examine the varied diagnostic criteria for common migraine utilized by epileptologists and other neurologists, to review clinical migraine epilepsy relationships, EEG abnormalities in migraine and epilepsy, and the association of seizures with vascular headache in patients with various forms of epilepsy. Hopefully, this will stimulate further research into this intriguing association of two conditions which though they have different pathophysiology frequently coexist. PMID:11231222

  8. Are children affected by epileptic neuropsychiatric comorbidities?

    PubMed

    Terra, Vera Cristina; de Paola, Luciano; Silvado, Carlos Eduardo

    2014-09-01

    Childhood-onset epilepsy is associated with psychiatric and cognitive difficulties and with poor social outcomes in adulthood. Some antiepileptic drugs adversely affect behavior in susceptible children with easy-to-control or refractory epilepsies, contributing to a high risk of psychological and psychiatric disturbance. Studies had demonstrated that patients with benign rolandic epilepsy and absence epilepsy had more aggressive behavior, depression, and anxiety disorders than control children. Psychiatric comorbidities are strongly associated with a poor long-term health-related quality of life in childhood-onset epilepsy, which suggests that comprehensive epilepsy care must include screening and long-term treatment for these conditions, even if seizures remit.

  9. Spatial disorientation in right-hemisphere infarction.

    PubMed Central

    Meerwaldt, J D; van Harskamp, F

    1982-01-01

    Spatial orientation was tested with the rod orientation test. The subjects were 40 normal controls and 68 brain-damaged patients with cerebral infarcts. Patients in whom the lesion included the post-rolandic region of the right hemisphere performed worse than controls or patients with lesions at other sites. Patients with an exclusively postrolandic (usually occipital) lesion showed higher error rates than patients with a combined prerolandic and postrolandic lesion, but only for the visual part of the test. These patients were re-examined one year after the stroke. Most of them showed an incomplete recovery of spatial function. PMID:7119828

  10. A quasi-Newton acceleration for high-dimensional optimization algorithms.

    PubMed

    Zhou, Hua; Alexander, David; Lange, Kenneth

    2011-01-01

    In many statistical problems, maximum likelihood estimation by an EM or MM algorithm suffers from excruciatingly slow convergence. This tendency limits the application of these algorithms to modern high-dimensional problems in data mining, genomics, and imaging. Unfortunately, most existing acceleration techniques are ill-suited to complicated models involving large numbers of parameters. The squared iterative methods (SQUAREM) recently proposed by Varadhan and Roland constitute one notable exception. This paper presents a new quasi-Newton acceleration scheme that requires only modest increments in computation per iteration and overall storage and rivals or surpasses the performance of SQUAREM on several representative test problems.

  11. Epileptiform activity in children with developmental dysphasia: quantification of discharges in overnight sleep video-EEG.

    PubMed

    Neuschlová, Lenka; Sterbová, Katalin; Zácková, Jitka; Komárek, Vladimír

    2007-12-01

    We present results of analysis of overnight sleep video-EEG in 8 patients with developmental dysphasia and rolandic discharges. We evaluated the incidence of epileptiform discharges (expressed as paroxysmal activity density) at one or more electrodes in different sleep stages in three different periods of the night (after falling asleep, around midnight and before awakening). The difference of paroxysmal activity density was never higher than 21%, indicating that quantifying the discharges in the whole night recording is not necessary. We also showed that two independent foci may differ in the frequency of discharges. We propose a scheme for evaluation of EEG reflecting both frequency and distribution of discharges.

  12. Local ICA for the Most Wanted face recognition

    NASA Astrophysics Data System (ADS)

    Guan, Xin; Szu, Harold H.; Markowitz, Zvi

    2000-04-01

    Facial disguises of FBI Most Wanted criminals are inevitable and anticipated in our design of automatic/aided target recognition (ATR) imaging systems. For example, man's facial hairs may hide his mouth and chin but not necessarily the nose and eyes. Sunglasses will cover the eyes but not the nose, mouth, and chins. This fact motivates us to build sets of the independent component analyses bases separately for each facial region of the entire alleged criminal group. Then, given an alleged criminal face, collective votes are obtained from all facial regions in terms of 'yes, no, abstain' and are tallied for a potential alarm. Moreover, and innocent outside shall fall below the alarm threshold and is allowed to pass the checkpoint. Such a PD versus FAR called ROC curve is obtained.

  13. Lightweight device to stimulate and monitor human vestibulo-ocular reflex

    NASA Technical Reports Server (NTRS)

    McStravick, M. Catherine (Inventor); Proctor, David R. (Inventor); Wood, Scott J. (Inventor)

    1989-01-01

    A helmet formed of a rigid shell is disclosed. The shell is lined with several air filled bladders to contact firmly the head of a user. The shell has a rigid chin bar supporting a bite bar connected fixedly to a mouthpiece bearing against the teeth and hard palate to firmly anchor the helmet without movement. The outer shell surface supports various air pumping bulbs and accelerometers. Separate left and right visor pivot on the side guided in a central tongue and groove track to move optical lens mounts into the user's field of vision. The chin bar is connected to the shell by a pair of releasable clasps. A safety lanyard connects to the clasps to quickly pull pins from the clasps to enable quick release in case of motion sickness.

  14. A case of juvenile hyaline fibromatosis.

    PubMed

    Yayli, Savaş; Uncu, Sibel; Alpay, Köksal; Yildiz, Kadriye; Cimşit, Gülseren; Bahadir, Sevgi

    2006-04-01

    Juvenile hyaline fibromatosis (JHF) is a rare, autosomally-recessive disease characterized by papulonodular skin lesions, soft tissue masses, joint contractures, gingival hypertrophy and osteolytic bone lesions. Its onset is in infancy or early childhood. The most commonly affected sites are the nose, chin, ears, scalp, back and knees. The accumulation of an amorphous, hyaline material is typical in the skin and the other organs. Herein, we report a 14-month-old boy who presented with confluent pink papules on the paranasal folds and the chin, and nodular lesions on the periauricular and perianal regions. He had gingival hypertrophy and contractures of the shoulders, knees and elbows. He also had third-degree consanguineous parents. Histopathological studies confirmed the diagnosis of JHF with the presence of increased numbers of fibroblasts embedded in a hyalinized connective tissue stroma.

  15. Review of rapid eye movement behavior sleep disorders.

    PubMed

    Abad, Vivien C; Guilleminault, Christian

    2004-03-01

    The spectrum of rapid eye movement behavior disorders (RBD) spans various age groups, with the greatest prevalence in elderly men. Major diagnostic features include harmful or potentially harmful sleep behaviors that disrupt sleep continuity and dream enactment during rapid eye movement sleep. In RBD patients, the polysomnogram during rapid eye movement sleep demonstrates excessive augmentation of chin electromyogram or excessive chin or limb phasic electromyogram twitching. RBD may be associated with various neurodegenerative disorders, such as multiple system atrophy, Parkinson's disease, and dementia with Lewy bodies. Other co-morbid conditions may include narcolepsy, agrypnia excitata, sleepwalking, and sleep terrors. RBD is hypothesized to be caused by primary dysfunction of the pedunculo-pontine nucleus or other key brainstem structures associated with basal ganglia pathology or, alternatively, from abnormal afferent signals in the basal ganglia leading to dysfunction in the midbrain extrapyramidal area/ pedunculo-pontine nucleus regions. PMID:14984689

  16. Combined Treatment with Botulinum Toxin and 595-nm Pulsed Dye Laser for Traumatic Scarring.

    PubMed

    Lee, Sang Ju; Jeong, Se Yeong; No, Yeon A; Park, Kui Young; Kim, Beom Joo

    2015-12-01

    Traumatic scars on skin covering areas of high movement, especially areas on the face, can be stressful for patients. We report two cases of traumatic scars that occurred on the chin, and that were successfully treated with a combined therapy of 595-nm pulsed dye laser (PDL) and intramuscular injection of botulinum toxin. After the treatment, good cosmetic results were achieved in both patients. The only adverse effect during and after the treatments was mild pain, which resolved within several days without any additional treatment. In conclusion, the combination of 595-nm PDL and intramuscular botulinum toxin injection was shown to be a safe and effective treatment for traumatic scars on the mobile chin area in Korean patients. PMID:26719648

  17. Penning trap mass measurement of 72Br

    NASA Astrophysics Data System (ADS)

    Valverde, A. A.; Bollen, G.; Cooper, K.; Eibach, M.; Gulyuz, K.; Izzo, C.; Morrissey, D. J.; Ringle, R.; Sandler, R.; Schwarz, S.; Sumithrarachchi, C. S.; Villari, A. C. C.

    2015-03-01

    The Low Energy Beam and Ion Trap (LEBIT) Penning trap mass spectrometer was used to perform an improved-precision mass measurement of 72Br and the low-lying isomeric state, Brm72, giving mass excesses of -59 062.2 (1.0 )keV and -58 960.9 (1.2 )keV , respectively. These values are consistent with the values from the 2012 atomic mass evaluation [Chin. Phys. C 36, 1603 (2012), 10.1088/1674-1137/36/12/003] and the Nubase2012 evaluation of nuclear properties [Chin. Phys. C 36, 1157 (2012), 10.1088/1674-1137/36/12/001]. The uncertainties on the mass of the ground state and isomeric state have been reduced by a factor of seven.

  18. Orocutaneous Fistula or Traumatic Infectious Skin Lesion: A Diagnostic Dilemma

    PubMed Central

    Vermani, Mayank; Kalia, Vimal; Singh, Sumita; Garg, Sunny; Aggarwal, Shweta; Khurana, Richa; Kalra, Geeta

    2015-01-01

    Orocutaneous fistula (OCF) (of dental origin) is an uncommon but well-described condition in the literature. These are often misdiagnosed by physicians and dentists. Careful selection of investigating modality is important in case of diagnostically challenging cases. A 19-year-old female came with a complaint of a lesion on the chin reported with h/o trauma with the impact on chin presented as diagnostic dilemma because of unusual case history and clinical examination. Commonly used radiographic investigations like IOPA and orthopantomograph did not resolve the dilemma whereas advanced imaging modality like CT scan, 3D volume imaging, and contrast enhanced CT played an important role in the diagnosis of OCF and selecting the treatment plan. PMID:26618009

  19. Sensory Hairs in the Bowhead Whale, Balaena mysticetus (Cetacea, Mammalia).

    PubMed

    Drake, Summer E; Crish, Samuel D; George, John C; Stimmelmayr, Raphaella; Thewissen, J G M

    2015-07-01

    We studied the histology and morphometrics of the hairs of bowhead whales (Balaena mysticetus). These whales are hairless except for two patches of more than 300 hairs on the rostral tip of the lower lip and chin, the rostral tip of the upper lip, and a bilateral row of approximately ten hairs caudal to the blowhole. Histological data indicate that hairs in all three of these areas are vibrissae: they show an outermost connective tissue capsule, a circumferential blood sinus system surrounding the hair shaft, and dense innervation to the follicle. Morphometric data were collected on hair diameters, epidermal recess diameters, hair follicle length, and external hair lengths. The main difference between the hairs in the different regions is that blowhole hairs have larger diameters than the hairs in the chin and rostrum regions. We speculate that the hair shaft thickness patterns in bowheads reflect functional specializations.

  20. Gnatophyma - A rare form of rosacea*

    PubMed Central

    de Macedo, Ana Carolina Lisboa; Sakai, Fernanda Dias Pacheco; de Vasconcelos, Rossana Cantanhede Farias; Duarte, Artur Antonio

    2012-01-01

    Phyma is the last stage of rosacea and is due to chronic inflammation and edema. It can affect nose (rhinophyma), chin (gnatophyma), forehead (metophyma), ears (otophyma) and eyelids (blepharophyma). Rhinophyma is the most frequent location and there are few reports about gnatophyma. We report the case of a female patient, 41 years old, who had an infiltrated, erythematous, edematous plaque around the chin and lower lip for two years. Histopathology showed perivascular lymphocytic infiltrate, hypertrophied follicles and sebaceous glands, dilated vessels and fibrosis. She was treated with oral tetracycline, oral ivermectin and metronidazole cream with a satisfactory response. The clinical, histopathological and therapeutic response correlation confirmed the diagnosis of gnatophyma, a rare variant of phyma. PMID:23197212

  1. A class of physical modeling recurrent networks for analysis/synthesis of plucked string instruments.

    PubMed

    Su, A Y; Liang, Sheng-Fu

    2002-01-01

    A new approach is proposed that closely synthesizes tones of plucked string instruments by using a class of physical modeling recurrent networks. The strategies employed consist of a fast training algorithm and a multistage training procedure that are able to obtain the synthesis parameters for a specific instrument automatically. The training vector can be recorded tones of most target plucked instruments with ordinary microphones. The proposed approach delivers encouraging results when it is applied to different types of plucked string instruments such as steel-string guitar, nylon-string guitar, harp, Chin, Yueh-chin, and Pipa. The synthesized tones sound very close to the originals produced by their acoustic counterparts. In addition, the paper presents an embedded technique that can produce special effects such as vibrato and portamento that are vital to the playing of plucked-string instruments. The computation required in the resynthesis processing is also reasonable. PMID:18244510

  2. Managing the Cutaneous Sinus Tract of Dental Origine

    PubMed Central

    Janev, Edvard; Redzep, Enis

    2016-01-01

    BACKGROUND: Draining cutaneous sinus tract in chin area may be caused by chronic periapical dental infections. Misdiagnosis of these lesions usually leads to destructive invasive treatment of the sinus tract that is not correct and curative. CASE REPORT: A 31-year-old male patient referred to us with a chronically draining lesion on his chin. The lesion previously was misdiagnosed by medical doctors and had undergone two times surgery with a focus on the skin lesion and had received antibiotic therapy for a prolonged period of time. After clinical and radiologic examination the dental origin of the lesion was evident and proper endodontic and surgical treatment was performed. Three months later, after the treatment, the lesion showed total healing and reoccurrence occurred. CONCLUSION: The key to successful treatment of cutaneous sinus tract of dental origin must be in appropriate communication between the dentist and the physician in order to achieve correct diagnosis and therapy in such cases. PMID:27703580

  3. Enhancement of the results of neck liposuction with the FAMI technique.

    PubMed

    Butterwick, Kimberly J

    2003-10-01

    Submental liposuction is an excellent procedure for improving the aging neck by reducing the cervicomental angle and increasing the definition of the mandibular border. However, it does not address the loss of volume of the chin and perioral areas caused by atrophy of hard and soft tissues. In this study, thirty patients underwent concomitant submental tumescent liposuction and fat augmentation with the FAMI (fat autograft muscle injection) technique in order to assess short-term results and complications associated with these two relatively noninvasive procedures. All patients had improvement in the cervicomental border, a smoother mandibular border, and a more proportioned chin following 3-5 days of swelling. Patients followed for 6 months to one year had long term retention of fat. There were no significant complications. In this preliminary series, submental tumescent liposuction with FAMI provided enhanced aesthetic results with little downtime and minimal complications. PMID:14558395

  4. The "baseball cap orthosis": a simple solution for dropped head syndrome.

    PubMed

    Fast, Avital; Thomas, Mark A

    2008-01-01

    Dropped head syndrome (DHS) is a well-recognized condition characterized by gradual sagging of the head. At the extreme, the condition may lead to a "chin on chest deformity" where the chin rests on the chest wall and the patient is unable to look straight ahead. Dropped head syndrome tends to develop in patients with severe weakness of the neck extensors. Various neuromuscular disorders and surgical procedures may compromise the stability of the cervical spine and lead to this disorder. The condition may severely compromise the patient's quality of life and result in significant disability. A simple device-the "baseball cap orthosis"-was developed to help patients maintain their head in the upright position. Two patients with DHS who were provided with the baseball cap orthosis are presented.

  5. [Electromyography of perioral muscles in the cleft lip and palate patients with crossbite].

    PubMed

    Li, W R; Lin, J X; Fu, M K

    1994-11-01

    In this study, twenty-nine cleft lip and palate patients with anterior crossbite were chosen as study group and twenty-eight normal children, twenty-seven patients with anterior crossbite as the control groups. All subjects were examined with EMG, and found some characters of the perioral muscles activity of the cleft patients. (1) The electromyographic amplitude of the upper lip and chin muscles was higher in cleft patients than that of other two groups during swallowing of saliva (2) Activity of chin muscle in cleft patients and crossbite patients in rest position were higher than that of normal occlusion (3) The Asymmetry index of the activity of upper lip muscle in every functional positions of the cleft patients are higher than ther groups. The abnormal activity of perioral muscles of the cleft patients demonstrate that functional repairment of cleft lip and needed lip bumper are necessary.

  6. Age differences and structural validity for the Greek version of the Body Cathexis Scale.

    PubMed

    Theodorakis, Y; Doganis, G; Bagiatis, K

    1991-02-01

    To examine age differences and the internal structure of the Greek version of the Body Cathexis Scale, 152 women 18 to 45 yr. of age and participating in physical fitness programs took the scale. High internal consistency was evident: in item analysis rs ranged from .29 to .68, split-half r was .89, and Cronbach alpha .92. Factor analysis yielded six factors: (1) Physical Fitness, (2) Total Appearance, (3) Health and Skills, (4) Face, (5) Ears and Chin, and (6) Extremities. These explained 52.5% of the total variance. The higher body satisfaction was observed on the factors, Health and Skills, Ears and Chin, and Extremities. Multivariate analysis of variance of body satisfaction across factors indicated no differences. PMID:2034776

  7. Sex and age identification of palila

    USGS Publications Warehouse

    Jeffrey, J.J.; Fancy, S.G.; Lindsey, G.D.; Banko, P.C.; Pratt, T.K.; Jacobi, J.D.

    1993-01-01

    Methods to sex and age Palila (Loxioides bailleui), an endangered Hawaiian finch restricted to subalpine woodlands on Hawai'i, were identified on the basis of measurements and plumage characteristics of 17 museum specimens and 96 known-age, live Palila. Palila undergo a single annual molt during September-December following the breeding season. Presence of a complete or partial wingbar distinguishes hatch-year and second-year Palila from after-second-year birds. Adult male Palila are distinguished from females by a distinct napeline and lt 30% gray feathers intermixed with yellow feathers on the head. The black or gray feathers of the lores and chin of males are darker than those on the back, whereas the lores and chin of females are lighter or of the same shade as back feathers.

  8. [Progress of study on the demodex blepharitis].

    PubMed

    Zhang, X Y; Sun, X G

    2016-04-11

    Demodex blepharitis is an infectious ocular disease which is common, but always to be neglected. There were a few related reports about this disease in China. The pathogenic mechanism of demodex blepharitis is not clear at present. Literatures held different ideas about its diagnosis, therapeutic methods and curative effect. This review will summarize the new development of demodex blepharitis in order to provide references for its basic and clinical researches.(Chin J Ophthalmol, 2016, 52: 315-320).

  9. Reconstruction of particle-size distributions from light-scattering patterns using three inversion methods.

    PubMed

    Vargas-Ubera, Javier; Aguilar, J Félix; Gale, David Michel

    2007-01-01

    By means of a numerical study we show particle-size distributions retrieved with the Chin-Shifrin, Phillips-Twomey, and singular value decomposition methods. Synthesized intensity data are generated using Mie theory, corresponding to unimodal normal, gamma, and lognormal distributions of spherical particles, covering the size parameter range from 1 to 250. Our results show the advantages and disadvantages of each method, as well as the range of applicability for the Fraunhofer approximation as compared to rigorous Mie theory.

  10. Interorganizational health care systems implementations: an exploratory study of early electronic commerce initiatives.

    PubMed

    Payton, F C; Ginzberg, M J

    2001-01-01

    Changing business practices, customers needs, and market dynamics have driven many organizations to implement interorganizational systems (IOSs). IOSs have been successfully implemented in the banking, cotton, airline, and consumer-goods industries, and recently attention has turned to the health care industry. This article describes an exploratory study of health care IOS implementations based on the voluntary community health information network (CHIN) model. PMID:11293008

  11. [Pay attention to the donor material supply for corneal transplantation].

    PubMed

    Pan, Z Q; Liang, Q F

    2016-09-11

    Corneal transplantation is an important method in the treatment of corneal blindness. It is imperative to improve the treatment effectiveness of corneal disease and reduce the possibility of corneal blindness with the progress of corneal transplantation surgery, the construction and development of eye banks and the rational use of donor materials. This article reviews the component corneal transplantation technology promotion, eye bank construction and preparation of donor slices for component corneal transplantation surgery. (Chin J Ophthalmol, 2016, 52: 641-643). PMID:27647243

  12. ASK Magazine. No. 9

    NASA Technical Reports Server (NTRS)

    Post, Todd (Editor)

    2002-01-01

    Most of this issue is about ACE (Advanced Composition Explorer). We've collected stories by four members of the ACE management team: Don Margolies, the mission manager from Goddard Space Flight Center; Frandsen, science payloads manager from the Caltech Jet Propulsion Laboratory; Mary Chin, project manager in charge of spacecraft development at the Johns Hopkins Applied Physics Laboratory; and Frank Snow, operations and ground systems manager at Goddard.

  13. Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males.

    PubMed

    Wax, Benjamin; Kavazis, Andreas N; Luckett, William

    2016-01-01

    Citrulline-malate (CM) has been proposed to provide an ergogenic effect during resistance exercise; however, there is a paucity of research investigating these claims. Therefore, we investigated the impact that CM supplementation would have on repeated bouts of resistance exercise. Fourteen resistance-trained males participated in a randomized, counterbalanced, double-blind study. Subjects were randomly assigned to placebo (PL) or CM (8 g) and performed three sets each of chin-ups, reverse chin-ups, and push-ups to failure. One week later, subjects ingested the other supplement and performed the same protocol. Blood lactate (BLa), heart rate (HR), and blood pressure (BP) were measured preexercise, with BLa measured a second time immediately following the last set, while HR and BP were measured 5 and 10 min postexercise. Citrulline-malate ingestion significantly increased the amount of repetitions performed for each exercise (chin-ups: PL = 28.4 ± 7.1, CM = 32.2 ± 5.6, p = .003; reverse chin-ups: PL = 26.6 ± 5.6, CM = 32.1 ± 7.1, p = .017; push-ups: PL = 89.1 ± 37.4, CM = 97.7 ± 36.1, p < .001). Blood lactate data indicated a time effect (p < .001), but no treatment differences (p = .935). Systolic BP data did not show differences for time (p = .078) or treatment (p = .119). Diastolic BP data did not show differences for time (p = .069), but indicated treatment differences (p = .014) for subjects ingesting CM. Collectively, these findings suggests that CM increased upper-body resistance performance in trained college-age males. PMID:25674699

  14. Energy requirements of gamefield exercises designed for wheelchair-bound persons.

    PubMed

    Cardús, D; McTaggart, W G; Ribas-Cardús, F; Donovan, W H

    1989-02-01

    This report presents energy requirements of three athletic exercises (power ramp, climber, and chin-ups) in a free-wheeling gamefield developed by the City of Houston for wheelchair-bound persons. Heart rate was monitored by telemetry. Expired gas samples were collected in Douglas bags. Oxygen and CO2 concentrations were determined by mass spectrometry and expired gas volumes by a wet gas meter. Pulmonary ventilation, O2 consumption, and CO2 production were calculated from expired gas samples. Laboratory studies were conducted on eight men with paraplegia and ten untrained, healthy, able-bodied men. The same persons were tested on the gamefield while propelling a wheelchair over the power ramp, the climber, and doing chin-ups. Age and weight were 32 +/- 4yrs vs 31 +/- 6yrs and 79.6kg vs 79.0kg, respectively, for paraplegic and healthy men. Paraplegic men had average heart rates of 133 +/- 11bpm, 133 +/- 19bpm, and 135 +/- 21bpm, respectively, for the power ramp, climber, and chin-ups. Heart rate values for able-bodied men were 136 +/- 26bpm, 139 +/- 24bpm, and 136 +/- 26bpm, respectively, for the same three exercises. The paraplegic men's VO2 measurements were 13.2 +/- 2.2, 11.5 +/- 2.8, and 6.4 +/- 2.9ml/min/kg, respectively, for the power ramp, climber, and chin-ups. The able-bodied men's VO2 measurements were 15.8 +/- 2.8, 15.4 +/- 3.6, and 9.2 +/- 2.8 ml/min/kg for the same exercises. Patients with paraplegia seemed to outperform able-bodied men in all events. Gamefield exercises appeared to tax the cardiorespiratory system at a level comparable to that usually prescribed for training purposes. PMID:2916929

  15. Immediate 3-dimensional ridge augmentation after extraction of periodontally hopeless tooth using chinblock graft

    PubMed Central

    Desai, Ankit; Thomas, Raison; A. Baron, Tarunkumar; Shah, Rucha; Mehta, Dhoom-Singh

    2015-01-01

    Background The aim of the present study was to evaluate clinically and radiographically, the efficacy of immediate ridge augmentation to reconstruct the vertical and horizontal dimensions at extraction sites of periodontally hopeless tooth using an autogenous chin block graft. Material and Methods A total of 11 patients (7 male & 4 female) with localized advanced bone loss around single rooted teeth having hopeless prognosis and indicated for extraction were selected for the study. The teeth were atraumatically extracted and deficient sites were augmented using autogenous chin block graft. Parameters like clinically soft tissue height - width and also radiographic ridge height -width were measured before and 6 months after augmentation. Obtained results were tabulated and analysed statistically. Results After 6 months of immediate ridge augmentation, the mean gain in radiographic vertical height and horizontal width was 7.64 + 1.47 mm (P = 0.005) and 5.28 + 0.46 mm (P = 0.007) respectively which was found to be statistically significant (P < 0.05). Mean change of width gain of 0.40mm and height loss of 0.40mm of soft tissue parameters, from the baseline till completion of the study at 6 months was observed. Conclusions The present study showed predictable immediate ridge augmentation with autogenous chin block graft at periodontally compromised extraction site. It can provide adequate hard and soft tissue foundation for perfect 3-Dimensional prosthetic positioning of implant in severely deficient ridges. Key words:Immediate ridge augmentation, periondontally hopeless tooth, autogenous chin graft, dental implant. PMID:26644832

  16. Hyaluronic acid gel in skin rejuvenation.

    PubMed

    Carruthers, Jean; Carruthers, Alastair

    2006-01-01

    Hyaluronans have become the most popular agents used for soft tissue augmentation in the entire facial area. They are biodegradeable, nonpermanent and have a remarkable safety profile. Their natural biocompatibility means that no pretreatment skin test is necessary. The soft pliable enhancement of natural tissue turgor and contour makes them very acceptable in the lips and perioral and periocular regions. The more viscous agents are very helpful in the treatment of facial lipoatrophy particularly in the region of the cheeks and chin.

  17. Condylar hyperplasia.

    PubMed

    Shankar, Uma; Chandra, Subhash; Raju, B H V Rama Krishnam; Anitha, G; Srikanth, K Venkata; Laheji, Afshan

    2012-01-01

    Condylar hyperplasia (CH), as the name suggests, affects mandibular condyle producing overgrowth of condyle, which is characterized by a slowly progressive, usually unilateral enlargement of the mandible, facial asymmetry and deviation of chin to the unaffected side. The condition is known to be self-limiting, usually begins around puberty, but may not be recognized until later in life. This paper reports a case of severe facial asymmetry secondary to CH, which was successfully treated by high condylectomy only. PMID:23404027

  18. Cryptanalysis of fair quantum blind signatures

    NASA Astrophysics Data System (ADS)

    He, Li-Bao; Huang, Liu-Sheng; Yang, Wei; Xu, Rui

    2012-03-01

    We investigate the fair quantum blind signature scheme proposed by Wang and Wen [Wang T Y and Wen Q Y 2010 Chin. Phys. B 19 060307], which uses the fundamental properties of quantum mechanics and the availability of a trusted arbitrator. However, in this paper, we find that the protocol cannot satisfy the property of non-forgeability even under the condition that the trusted arbitrator is totally credible. Moreover, a simple feasible suggestion for improving the protocol is proposed.

  19. Correction of a mandibular asymmetry after fibula reconstruction using a custom-made polyetheretherketone (PEEK) onlay after implant supported occlusal rehabilitation.

    PubMed

    Berrone, M; Aldiano, C; Pentenero, M; Berrone, S

    2015-10-01

    This study describes an unusual case of mandibular asymmetry after fibula free flap reconstruction in a young man following major facial trauma that was corrected using a custom-made polyetheretherketone prosthesis. There is little information in the literature on the use of alloplasts to correct mandibular asymmetry as interest in 'aesthetic re-modelling' has traditionally focused on nasal, zygomatic and chin regions. This report demonstrates that this technique can be used successfully to address selected cases of mandibular asymmetry.

  20. Correction of a mandibular asymmetry after fibula reconstruction using a custom-made polyetheretherketone (PEEK) onlay after implant supported occlusal rehabilitation.

    PubMed

    Berrone, M; Aldiano, C; Pentenero, M; Berrone, S

    2015-10-01

    This study describes an unusual case of mandibular asymmetry after fibula free flap reconstruction in a young man following major facial trauma that was corrected using a custom-made polyetheretherketone prosthesis. There is little information in the literature on the use of alloplasts to correct mandibular asymmetry as interest in 'aesthetic re-modelling' has traditionally focused on nasal, zygomatic and chin regions. This report demonstrates that this technique can be used successfully to address selected cases of mandibular asymmetry. PMID:26824216

  1. Vertical Localization of the Malar Prominence

    PubMed Central

    Kaptein, John S.; Markarian, Alexander

    2015-01-01

    Background: During reconstruction or augmentation, it is important to localize the malar complex in a symmetrical and aesthetically pleasing position. Few studies have determined the location of this feature and none related the location to gender, age, or ethnicity. Some of these have attempted to relate the position to the aesthetically pleasing Golden Ratio φ. Methods: We assessed the vertical location of the malar prominence relative to other facial landmarks, determined consistency among individuals, and compared this with values used in artistry. Study population consisted of a convenience sample of 67 patients taken from an otolaryngology practice at a large urban medical center. Coordinates of the malar prominence were referenced to distinct facial landmarks from which the ratio of chin-to-malar prominence to chin-to-eye canthus was determined. Results: Average chin-to-malar prominence distance was 0.793 ± 0.023 (SD) of the chin-to-eye canthus distance. Variability due to the specific image chosen [coefficient of variation (CV) = 1.19%] and combined inter/intrareader variability (CV = 1.71%) validate the methodology. Variability among individuals (CV = 2.84%) indicates population consistency. No difference was found between gender and age groups or between whites and Hispanics. Individuals of other/unknown ethnicities were within the range common to whites and Hispanics. Our population’s value is not different from the value of 0.809 used in artistry, which is based on the Golden Ratio φ. Conclusions: The vertical position of the malar prominence is consistent among individuals, is clinically well-approximated by the value based on the Golden Ratio, and may be useful as a reference for surgical reconstruction or augmentation. PMID:26180712

  2. [Progress of study on the demodex blepharitis].

    PubMed

    Zhang, X Y; Sun, X G

    2016-04-11

    Demodex blepharitis is an infectious ocular disease which is common, but always to be neglected. There were a few related reports about this disease in China. The pathogenic mechanism of demodex blepharitis is not clear at present. Literatures held different ideas about its diagnosis, therapeutic methods and curative effect. This review will summarize the new development of demodex blepharitis in order to provide references for its basic and clinical researches.(Chin J Ophthalmol, 2016, 52: 315-320). PMID:27094071

  3. Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training.

    PubMed

    Greer, Beau K; Jones, Brett T

    2011-07-01

    Dietary supplement companies claim that arginine supplements acutely enhance skeletal muscular endurance. The purpose of this study was to determine whether acute arginine α-ketoglutarate supplementation (AAKG) will affect local muscle endurance of the arm and shoulder girdle or the blood pressure (BP) response to anaerobic exercise. Twelve trained college-aged men (22.6 ± 3.8 years) performed 2 trials of exercise separated by at least 1 week. At 4 hours before, and 30 minutes before exercise, a serving of an AAKG supplement (3,700 mg arginine alpha-ketoglutarate per serving) or placebo was administered. Resting BP was assessed pre-exercise after 16 minutes of seated rest, and 5 and 10 minutes postexercise. Three sets each of chin-ups, reverse chin-ups, and push-ups were performed to exhaustion with 3 minutes of rest between each set. Data were analyzed using repeated-measures analysis of variance and paired t-tests. The AAKG supplementation did not improve muscle endurance or significantly affect the BP response to anaerobic work. Subjects performed fewer total chin-ups (23.75 ± 6.38 vs. 25.58 ± 7.18) and total trial repetitions (137.92 ± 28.18 vs. 141.08 ± 28.57) in the supplement trial (p ≤ 0.05). Subjects executed fewer reverse chin-ups (5.83 ± 1.85 vs. 6.75 ± 2.09) during set 2 after receiving the supplement as compared to the placebo (p < 0.05). Because AAKG supplementation may hinder muscular endurance, the use of these supplements before resistance training should be questioned.

  4. Allergy to metal caused by materials used for intermaxillary fixation: case report.

    PubMed

    Hashitani, Susumu; Maeda, Tsunenari; Okui, Shin; Takaoka, Kazuki; Honda, Kosuke; Urade, Masahiro

    2008-06-01

    A 21-year-old man with no history of contact allergy developed eczema over his entire body 2 days after he had had intermaxillary fixation (IMF) of a mandibular fracture. Patch testing showed a strong reaction to nickel so the arch bars and wires that had been used for fixation were removed and replaced with resin brackets, elastic bands, and a chin cap. The eczema disappeared 2 days later.

  5. Effects of functional orthodontic appliances in the correction of a primary anterior crossbite--changes in craniofacial morphology and tongue position.

    PubMed

    Onodera, Kieko; Niikuni, Naoko; Yanagisawa, Munemitsu; Nakajima, Ichiro

    2006-08-01

    Chin caps have been used for the correction of primary anterior crossbites, but previous studies of the treatment effects have highlighted problems such as pressure on the temporomandibular joint (TMJ). Therefore, to reduce pressure on the TMJ, a functional orthodontic appliance, the Yanagisawa Class III (YC3) shield was developed to improve the overjet in the primary dentition. The aim of this study was to determine the treatment effects of the YC3 in correcting a primary anterior crossbite compared with a chin cap. The pre- and post-treatment lateral cephalograms of 10 patients (5 male, 5 females) and 10 treated with a YC3 (5 males, 5 females) were compared in relation to craniofacial morphology and tongue position [the YC3 was used from 51 months of age +/- 7 months to 74 months of age +/- 12 months (i.e. for 23 +/- 9 months) and the chin cap from 53 months of age +/- 2 months to 75 months of age +/- 1 month (i.e. for 22 +/- 5 months)]. A Mann-Whitney U-test was used to determine any statistical differences. The YC3 group showed significantly higher values for gonial angle and U1 to SN (P < 0.05), and significantly lower values for interincisal and tongue position (P < 0.05), compared with the chin cap group. The results indicate that the use of the YC3 not only improves overjet, but also changes the tongue position. The findings also suggest that the YC3 results in functional effects on the skeletal system during the mid-growth period.

  6. Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males.

    PubMed

    Wax, Benjamin; Kavazis, Andreas N; Luckett, William

    2016-01-01

    Citrulline-malate (CM) has been proposed to provide an ergogenic effect during resistance exercise; however, there is a paucity of research investigating these claims. Therefore, we investigated the impact that CM supplementation would have on repeated bouts of resistance exercise. Fourteen resistance-trained males participated in a randomized, counterbalanced, double-blind study. Subjects were randomly assigned to placebo (PL) or CM (8 g) and performed three sets each of chin-ups, reverse chin-ups, and push-ups to failure. One week later, subjects ingested the other supplement and performed the same protocol. Blood lactate (BLa), heart rate (HR), and blood pressure (BP) were measured preexercise, with BLa measured a second time immediately following the last set, while HR and BP were measured 5 and 10 min postexercise. Citrulline-malate ingestion significantly increased the amount of repetitions performed for each exercise (chin-ups: PL = 28.4 ± 7.1, CM = 32.2 ± 5.6, p = .003; reverse chin-ups: PL = 26.6 ± 5.6, CM = 32.1 ± 7.1, p = .017; push-ups: PL = 89.1 ± 37.4, CM = 97.7 ± 36.1, p < .001). Blood lactate data indicated a time effect (p < .001), but no treatment differences (p = .935). Systolic BP data did not show differences for time (p = .078) or treatment (p = .119). Diastolic BP data did not show differences for time (p = .069), but indicated treatment differences (p = .014) for subjects ingesting CM. Collectively, these findings suggests that CM increased upper-body resistance performance in trained college-age males.

  7. Epidermal electronics for electromyography: An application to swallowing therapy.

    PubMed

    Constantinescu, Gabriela; Jeong, Jae-Woong; Li, Xinda; Scott, Dylan K; Jang, Kyung-In; Chung, Hyun-Joong; Rogers, John A; Rieger, Jana

    2016-08-01

    Head and neck cancer treatment alters the anatomy and physiology of patients. Resulting swallowing difficulties can lead to serious health concerns. Surface electromyography (sEMG) is used as an adjuvant to swallowing therapy exercises. sEMG signal collected from the area under the chin provides visual biofeedback from muscle contractions and is used to help patients perform exercises correctly. However, conventional sEMG adhesive pads are relatively thick and difficult to effectively adhere to a patient's altered chin anatomy, potentially leading to poor signal acquisition in this population. Here, the emerging technology of epidermal electronics is introduced, where ultra-thin geometry allows for close contouring of the chin. The two objectives of this study were to (1) assess the potential of epidermal electronics technology for use with swallowing therapy and (2) assess the significance of the reference electrode placement. This study showed comparative signals between the new epidermal sEMG patch and the conventional adhesive patches used by clinicians. Furthermore, an integrated reference yielded optimal signal for clinical use; this configuration was more robust to head movements than when an external reference was used. Improvements for future iterations of epidermal sEMG patches specific to day-to-day clinical use are suggested.

  8. Craniofacial morphologic parameters in a Persian population: an anthropometric study.

    PubMed

    Amini, Fariborz; Mashayekhi, Ziba; Rahimi, Hajir; Morad, Golnaz

    2014-09-01

    Limited data are available regarding the reference ranges of facial proportions of the Persian population in Iran. This study aimed to establish the reference range of craniofacial anthropometric measurements in an adult Iranian population. On 100 individuals (men = women), aged 18 to 30 years with normal faces and occlusions, 34 linear and 7 angular measurements as well as 24 indices were calculated. The difference of measurements between men and women were evaluated by paired t-test. The data were compared with the norms of North American whites using 1-sample t-test. The subjects belonged to 5 ethnic groups (57% from Fars, 14% from Kord, 11% from Azari, 10% from Gilaki-Mazani, and 2% from Lor). All head measurements were greater in men except for the head index and the head height. The subjects had leptoprosopic faces. The intercanthal width was almost one third of the biocular width and greater than the eye fissure length. Although the nose width of women was significantly smaller, both sexes had leptorrhine noses. The chin height and lower chin height were greater in men. In comparison with North American whites, considerable differences were found regarding head height and width, biocular width, nose height, face height, mouth width, and upper chin height. In conclusion, the reference range of craniofacial anthropometric measurements established for the Iranian population might be efficiently used for esthetic treatments.

  9. Estimation of Delta Wave by Mutual Information of Heartbeat During Sleep

    NASA Astrophysics Data System (ADS)

    Kurihara, Yosuke; Watanabe, Kajiro; Kobayashi, Kazuyuki; Tanaka, Hiroshi

    The quality of sleep is evaluated based on the sleep stages judged by R-K method or the manual of American Academy of Sleep Medicine. The brainwaves, eye movements, and chin EMG of sleeping subjects are used for the judgment. These methods above, however, require some electrodes to be attached to the head and the face to obtain the brainwaves, eye movements, and chin EMG, thus making the measurements troublesome to be held on a daily basis. If non-invasive measurements of brainwaves, eye movements, and chin EMG are feasible, or their equivalent data can be estimated through other bio-signals, the monitoring of the quality of daily sleeps, which influences the health condition, will be easy. In this paper, we discuss the appearance rate of delta wave occurrences, which is deeply related with the depth of sleep, can be estimated based on the average amount of mutual information calculated by pulse wave signals and body movements measured non-invasively by the pneumatic method. As a result, the root mean square error between the appearance rate of delta wave occurrences measured with a polysomnography and the estimated delta pulse was 14.93%.

  10. Relevance of mating-associated stimuli, ovulation, and the progesterone receptor for the post-coital inhibition of estrous behavior in the female rabbit.

    PubMed

    Hoffman, Kurt L; Rueda Morales, Rafael I; González-Mariscal, Gabriela

    2010-11-01

    Estrous female domestic rabbits (Oryctolagus cuniculus) display scent marking ("chinning") and sexual receptivity. Mating induces ovulation, which occurs approximately 12h later, and also decreases chinning and receptivity. In the present study, we explored the participation of mating-associated stimuli, ovulation, and the progesterone receptor (PR) in mediating such behavioral effects. We found that copulatory stimuli were not necessary, and that ovulation alone was sufficient, as these behavioral changes were replicated in unmated females by intravenous administration of human chorionic gonadotropin (hCG). The post-mating administration (s.c.) of 5μg/day estradiol benzoate (EB), prevented the decline in chinning and receptivity. A lower dose of EB (1μg/day) had no effect, nor did the antiprogestin RU486 (20mg, s.c., administered 3h before mating). However, the combination of a single pre-mating administration of RU486 plus the post-mating administration of 1μg/day EB completely blocked the decline in estrous behavior. We propose that PR activation around the time of mating and a post-mating decline in ovarian estradiol secretion and/or estradiol responsiveness act in parallel to terminate estrus in this species.

  11. Effects of mop handle height on shoulder muscle activity and perceived exertion during floor mopping using a figure eight method

    PubMed Central

    WALLIUS, Mari-Anne; RISSANEN, Saara M.; BRAGGE, Timo; VARTIAINEN, Paavo; KARJALAINEN, Pasi A.; RÄSÄNEN, Kimmo; JÄRVELIN-PASANEN, Susanna

    2015-01-01

    The aim of this study was to investigate effects of mop handle height on electromyographic (EMG) activities of the shoulder muscles and perceived exertion for the shoulder area during floor mopping using a figure eight method. An experimental study with 13 cleaners was conducted using surface EMG and category ratio (CR-10) scale. EMG activity was recorded unilaterally from the upper trapezius, infraspinatus, anterior and middle deltoid muscles. Each subject performed four trials of mopping and each trial consisted of using a different mop handle height (mop adjustment at the level of shoulder, chin, nose and eye) in randomized order. EMG data were normalized to a percentage of maximal voluntary contraction (%MVC). The muscle activities were assessed by estimating the 10th, 50th and 90th percentiles of the amplitude probability distribution function (APDF) of the EMG signals and analysed by linear mixed model analysis. Results showed that shoulder muscle activity was significantly lower when the mop handle height was adjusted to shoulder level or chin level as compared to eye level. These findings were supported by subjective ratings of exertion. It seems that mop handle height adjustment between shoulder and chin level may be recommended as a basis for figure eight mopping. PMID:26423328

  12. Epidermal electronics for electromyography: An application to swallowing therapy.

    PubMed

    Constantinescu, Gabriela; Jeong, Jae-Woong; Li, Xinda; Scott, Dylan K; Jang, Kyung-In; Chung, Hyun-Joong; Rogers, John A; Rieger, Jana

    2016-08-01

    Head and neck cancer treatment alters the anatomy and physiology of patients. Resulting swallowing difficulties can lead to serious health concerns. Surface electromyography (sEMG) is used as an adjuvant to swallowing therapy exercises. sEMG signal collected from the area under the chin provides visual biofeedback from muscle contractions and is used to help patients perform exercises correctly. However, conventional sEMG adhesive pads are relatively thick and difficult to effectively adhere to a patient's altered chin anatomy, potentially leading to poor signal acquisition in this population. Here, the emerging technology of epidermal electronics is introduced, where ultra-thin geometry allows for close contouring of the chin. The two objectives of this study were to (1) assess the potential of epidermal electronics technology for use with swallowing therapy and (2) assess the significance of the reference electrode placement. This study showed comparative signals between the new epidermal sEMG patch and the conventional adhesive patches used by clinicians. Furthermore, an integrated reference yielded optimal signal for clinical use; this configuration was more robust to head movements than when an external reference was used. Improvements for future iterations of epidermal sEMG patches specific to day-to-day clinical use are suggested. PMID:27255865

  13. Fungitoxic phenols from carnation (Dianthus caryophyllus) effective against Fusarium oxysporum f. sp. dianthi.

    PubMed

    Curir, Paolo; Dolci, Marcello; Dolci, Paola; Lanzotti, Virginia; De Cooman, Luc

    2003-01-01

    The phenol compositions of two cultivars of carnation (Dianthus caryophyllus) namely "Gloriana" and "Roland", which are partially and highly resistant, respectively, to Fusarium oxysporum f. sp. dianthi have been investigated with the aim of determining if endogenous phenols could have an anti-fungal effect against the pathogen. Analyses were performed on healthy and F. oxysporum-inoculated in vitro tissues, and on in vivo plants. Two benzoic acid derivatives, protocatechuic acid (3,4-dihydroxybenzoic acid) and vanillic acid (4-hydroxy-3-methoxybenzoic acid), were found within healthy and inoculated tissues of both cultivars, together with the flavonol glycoside peltatoside (3-[6-O-(alpha-L-arabinopyranosyl)-beta-D-glucopyranosyl] quercetin). These molecules proved to be only slightly inhibitory towards the pathogen. 2,6-Dimethoxybenzoic acid was detected in small amounts only in the inoculated cultivar "Gloriana", while the highly resistant cultivar "Roland" showed the presence of the flavone datiscetin (3,5,7,2'-tetrahydroxyflavone). The latter compound exhibited an appreciable fungitoxic activity towards F. oxysporum f. sp. dianthi.

  14. Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate.

    PubMed

    Hill, Shirley Y; Sharma, Vinod; Jones, Bobby L

    2016-09-30

    Lifetime measures of cannabis use and co-occurring exposures were obtained from a longitudinal cohort followed an average of 13 years at the time they received a structural MRI scan. MRI scans were analyzed for 88 participants (mean age=25.9 years), 34 of whom were regular users of cannabis. Whole brain voxel based morphometry analyses (SPM8) were conducted using 50 voxel clusters at p=0.005. Controlling for age, familial risk, and gender, we found reduced volume in Regular Users compared to Non-Users, in the lingual gyrus, anterior cingulum (right and left), and the rolandic operculum (right). The right anterior cingulum reached family-wise error statistical significance at p=0.001, controlling for personal lifetime use of alcohol and cigarettes and any prenatal exposures. CNR1 haplotypes were formed from four CNR1 SNPs (rs806368, rs1049353, rs2023239, and rs6454674) and tested with level of cannabis exposure to assess their interactive effects on the lingual gyrus, cingulum (right and left) and rolandic operculum, regions showing cannabis exposure effects in the SPM8 analyses. These analyses used mixed model analyses (SPSS) to control for multiple potentially confounding variables. Level of cannabis exposure was associated with decreased volume of the right anterior cingulum and showed interaction effects with haplotype variation.

  15. On the origin of the magnetic field in type-1 comet tails - A reply to Ershkovich

    NASA Technical Reports Server (NTRS)

    Mendis, D. A.

    1977-01-01

    Ershkovich (1976) employed the observed geometry of the type 1 tail of comet Arend-Roland 1957 III to show that any magnetic field present there cannot be of 'internal' origin but must have been 'captured' from the magnetized solar wind. Such an 'external' origin for the magnetic field in type 1 comet tails is not disputed, but several other points raised by Ershkovich are discussed. These concern the generation of substantial magnetic fields within the coma during periods when the comet's heliocentric distance is typically not greater than 1 AU, Ershkovich's use of the pressure balance across the tail 'tangential discontinuity' to estimate that the 'captured' magnetic field is of the order of the solar wind-field, his interpretation of certain observations of motions in the tail of comet Arend-Roland, and his assertion that the distant comet tail will be transformed into a turbulent wake due to the Kelvin-Helmholtz instability. It is argued that the 'captured' magnetic field should be substantially amplified relative to the solar-wind field, that the pressure-balance equation is of limited use, and that the real configuration of a type 1 tail must be treated in detail before any definite conclusions can be reached about the Kelvin-Helmholtz instability.

  16. An fMRI Study of Obesity, Food Reward, and Perceived Caloric Density: Does a Low-Fat Label Make Food Less Appealing?

    PubMed Central

    Ng, Janet; Stice, Eric; Yokum, Sonja; Bohon, Cara

    2011-01-01

    We tested the hypothesis that obese individuals experience greater activation of the gustatory and somatosensory cortex, but weaker activation of the striatum, in response to intake and anticipated intake of high-fat chocolate milkshake versus an isocaloric milkshake labeled low-fat and a tasteless solution using functional magnetic resonance imaging (fMRI) with 17 obese and 17 lean young women. Obese relative to lean women showed greater activation in somatosensory (Rolandic operculum), gustatory (frontal operculum), and reward valuation regions (amgydala, ventralmedial prefrontal cortex (vmPFC) in response to intake and anticipated intake of milkshake versus tasteless solution, though there was little evidence of reduced striatal activation. Obese relative to lean women also showed greater activation in the Rolandic operculum, frontal operculum, and vmPFC in response to isocaloric milkshakes labeled regular versus lowfat. Results suggest that hyper-responsivity of somatosensory, gustatory, and reward valuation regions may be related to overeating and that top-down processing influence reward encoding, which could further contribute to weight gain. PMID:21497628

  17. Words in melody: an H(2)15O PET study of brain activation during singing and speaking.

    PubMed

    Jeffries, K J; Fritz, J B; Braun, A R

    2003-04-15

    We used H(2)15O PET to characterize the interaction of words and melody by comparing brain activity measured while subjects spoke or sang the words to a familiar song. Relative increases in activity during speaking vs singing were observed in the left hemisphere, in classical perisylvian language areas including the posterior superior temporal gyrus, supramarginal gyrus, and frontal operculum, as well as in Rolandic cortices and putamen. Relative increases in activity during singing were observed in the right hemisphere: these were maximal in the right anterior superior temporal gyrus and contiguous portions of the insula; relative increases associated with singing were also detected in the right anterior middle temporal gyrus and superior temporal sulcus, medial and dorsolateral prefrontal cortices, mesial temporal cortices and cerebellum, as well as in Rolandic cortices and nucleus accumbens. These results indicate that the production of words in song is associated with activation of regions within right hemisphere areas that are not mirror-image homologues of left hemisphere perisylvian language areas, and suggest that multiple neural networks may be involved in different aspects of singing. Right hemisphere mechanisms may support the fluency-evoking effects of singing in neurological disorders such as stuttering or aphasia.

  18. Disrupted White Matter Network and Cognitive Decline in Type 2 Diabetes Patients.

    PubMed

    Zhang, Junying; Liu, Zhen; Li, Zixiao; Wang, Yunxia; Chen, Yaojing; Li, Xin; Chen, Kewei; Shu, Ni; Zhang, Zhanjun

    2016-05-01

    Type 2 diabetes mellitus is accompanied by cognitive impairment and is associated with an increased risk of dementia. Damage to brain structures such as white matter network disruption may underlie this cognitive disturbance. In the present study, 886 non-diabetic and 163 type 2 diabetic participants completed a battery of neuropsychological tests. Among them, 38 diabetic patients and 34 non-diabetic participants that matched the patients for age/sex/education received a magnetic resonance imaging-based diffusion tensor imaging. Then we calculated the topological properties of the white matter network using a graph theoretical method to investigate network efficiency differences between groups. We found that type 2 diabetic patients had inferior performances compared to the non-diabetic controls, in several cognitive domains involving executive function, spatial processing, memory, and attention. We also found that diabetic patients exhibited a disrupted topological organization of the white matter network (including the global network properties, i.e., network strength, global efficiency, local efficiency and shortest path length, and the nodal efficiency of the right rolandic operculum) in the brain. Moreover, those global network properties and the nodal efficiency of the right rolandic operculum both had positive correlations with executive function in the patient group. The results suggest that type 2 diabetes mellitus leads to an alteration in the topological organization of the cortical white matter network and this alteration may account for the observed cognitive decline.

  19. Probing of structural relaxation times in the glassy state of sucrose and trehalose based on dynamical properties of two secondary relaxation processes

    SciTech Connect

    Kaminski, K.; Adrjanowicz, K.; Paluch, M.; Kaminska, E.

    2011-06-15

    Time-dependent isothermal dielectric measurements were carried out deeply in the glassy state on two very important saccharides: sucrose and trehalose. In both compounds two prominent secondary relaxation processes were identified. The faster one is an inherent feature of the whole family of carbohydrates. The slower one can also be detected in oligo- and polysaccharides. It was shown earlier that the {beta} process is the Johari-Goldstein (JG) relaxation coupled to motions of the glycosidic linkage, while the {gamma} relaxation originates from motions of the exocyclic hydroxymethyl unit. Recently, it was shown that the JG relaxation process can be used to determine structural relaxation times in the glassy state [R. Casalini and C. M. Roland, Phys. Rev. Lett. 102, 035701 (2009)]. In this paper we present the results of an analysis of the data obtained during aging using two independent approaches. The first was proposed by Casalini and Roland, and the second one is based on the variation of the dielectric strength of the secondary relaxation process during aging [J. K. Vij and G. Power, J. Non-Cryst. Solids 357, 783 (2011)]. Surprisingly, we found that the estimated structural relaxation times in the glassy state of both saccharides are almost the same, independent of the type of secondary mode. This finding calls into question the common view that secondary modes of intramolecular origin do not provide information about the dynamics of the glassy state.

  20. Rapid distributed fronto-parieto-occipital processing stages during working memory in humans.

    PubMed

    Halgren, E; Boujon, C; Clarke, J; Wang, C; Chauvel, P

    2002-07-01

    Cortical potentials were recorded from implanted electrodes during a difficult working memory task requiring rapid storage, modification and retrieval of multiple memoranda. Synchronous event-related potentials were generated in distributed occipital, parietal, Rolandic and prefrontal sites beginning approximately 130 ms after stimulus onset and continuing for >500 ms. Coherent phase-locked, event-related oscillations supported interaction between these dorsal stream structures throughout the task period. The Rolandic structures generated early as well as sustained potentials to sensory stimuli in the absence of movement. Activation peaks and phase lags between synaptic populations suggested that perceptual processing occurred exclusively in the visual association cortex from approximately 90 to 130 ms, with its results projected to fronto-parietal areas for interpretation from approximately 130 to 280 ms. The direction of interaction then appeared to reverse from approximately 300 to 400 ms, consistent with mental arithmetic being performed by fronto-parietal areas operating upon a visual scratch pad in the dorsolateral occipital cortex. A second reversal, from approximately 420 to 600 ms, may have represented an updating of memoranda stored in fronto-parietal sites. Lateralized perisylvian oscillations suggested an articulatory loop. Anterior cingulate activity was evoked by feedback signals indicating errors. These results indicate how a fronto-centro-parietal 'central executive' might interact with an occipital visual scratch pad, perisylvian articulatory loop and limbic monitor to implement the sequential stages of a complex mental operation.

  1. Lifetime use of cannabis from longitudinal assessments, cannabinoid receptor (CNR1) variation, and reduced volume of the right anterior cingulate.

    PubMed

    Hill, Shirley Y; Sharma, Vinod; Jones, Bobby L

    2016-09-30

    Lifetime measures of cannabis use and co-occurring exposures were obtained from a longitudinal cohort followed an average of 13 years at the time they received a structural MRI scan. MRI scans were analyzed for 88 participants (mean age=25.9 years), 34 of whom were regular users of cannabis. Whole brain voxel based morphometry analyses (SPM8) were conducted using 50 voxel clusters at p=0.005. Controlling for age, familial risk, and gender, we found reduced volume in Regular Users compared to Non-Users, in the lingual gyrus, anterior cingulum (right and left), and the rolandic operculum (right). The right anterior cingulum reached family-wise error statistical significance at p=0.001, controlling for personal lifetime use of alcohol and cigarettes and any prenatal exposures. CNR1 haplotypes were formed from four CNR1 SNPs (rs806368, rs1049353, rs2023239, and rs6454674) and tested with level of cannabis exposure to assess their interactive effects on the lingual gyrus, cingulum (right and left) and rolandic operculum, regions showing cannabis exposure effects in the SPM8 analyses. These analyses used mixed model analyses (SPSS) to control for multiple potentially confounding variables. Level of cannabis exposure was associated with decreased volume of the right anterior cingulum and showed interaction effects with haplotype variation. PMID:27500453

  2. Effects of Biofreeze and chiropractic adjustments on acute low back pain: a pilot study☆

    PubMed Central

    Zhang, John; Enix, Dennis; Snyder, Brian; Giggey, Kristan; Tepe, Rodger

    2008-01-01

    Abstract Objective This randomized controlled study was designed to determine the pain-relieving effect of Biofreeze (Performance Health Inc., Export, PA) body surface application and chiropractic adjustments on subjects with acute low back pain (LBP). Methods The data were collected at the baseline, 2 weeks after treatment, and 4 weeks after treatment for final analyses. Diversified manual adjustments were provided by licensed chiropractors twice a week for 4 weeks to both control and experimental groups. Biofreeze was applied to the lower back area 3 times a day for 4 weeks in the experimental group. Outcome assessments included visual analog scale, Roland Morris Disability Questionnaire, heart rate variability for stress, and electromyography for low back muscle activity. Results A total of 36 subjects were recruited in the study (25 male). The average age was 34 years. Significant pain reduction was found after each week of treatment in the experimental group (P < .05). The Roland Morris Disability Questionnaire did not show significant changes in both groups. There were no significant differences for pain reduction in the control group. Heart rate variability analysis showed no significant change (P > .05) in the experimental group after 4 weeks of Biofreeze and chiropractic adjustments. There were no statistically significant changes in the electromyography readings between the 2 groups. Conclusion Biofreeze combined with chiropractic adjustment showed significant reduction in LBP. PMID:19674721

  3. Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain.

    PubMed

    Kivitz, Alan J; Gimbel, Joseph S; Bramson, Candace; Nemeth, Mary Anne; Keller, David S; Brown, Mark T; West, Christine R; Verburg, Kenneth M

    2013-07-01

    Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8weeks), naproxen (500mg twice daily), or placebo. The primary efficacy end point was mean change in daily average low back pain intensity (LBPI) from baseline to week 16. Secondary end points included mean change from baseline to week 16 in the Roland Morris Disability Questionnaire and Patient's Global Assessment (PGA) of low back pain. Tanezumab 10 and 20mg had similar efficacy profiles and significantly improved LBPI, Roland Morris Disability Questionnaire, and PGA scores vs both placebo and naproxen (P⩽.05). Tanezumab 5mg provided improvement of PGA scores vs placebo (P⩽.05), and naproxen resulted in significant improvement of LBPI vs placebo (P⩽.05). Adverse event incidence was comparable across tanezumab doses but higher than with placebo or naproxen. Arthralgia, pain in extremity, headache, and paresthesia were the most commonly reported adverse events by tanezumab-treated patients. The most frequently reported adverse events resulting in discontinuation of tanezumab treatment were arthralgia and paresthesia; the highest frequency was observed with tanezumab 20mg (both 1.4%). Serious adverse event incidence was similar across treatments. In conclusion, tanezumab provided significantly greater improvement in pain, function, and global scores vs placebo and naproxen in patients with chronic low back pain.

  4. GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction.

    PubMed

    Lesca, Gaetan; Rudolf, Gabrielle; Bruneau, Nadine; Lozovaya, Natalia; Labalme, Audrey; Boutry-Kryza, Nadia; Salmi, Manal; Tsintsadze, Timur; Addis, Laura; Motte, Jacques; Wright, Sukhvir; Tsintsadze, Vera; Michel, Anne; Doummar, Diane; Lascelles, Karine; Strug, Lisa; Waters, Patrick; de Bellescize, Julitta; Vrielynck, Pascal; de Saint Martin, Anne; Ville, Dorothee; Ryvlin, Philippe; Arzimanoglou, Alexis; Hirsch, Edouard; Vincent, Angela; Pal, Deb; Burnashev, Nail; Sanlaville, Damien; Szepetowski, Pierre

    2013-09-01

    Epileptic encephalopathies are severe brain disorders with the epileptic component contributing to the worsening of cognitive and behavioral manifestations. Acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and continuous spike and waves during slow-wave sleep syndrome (CSWSS) represent rare and closely related childhood focal epileptic encephalopathies of unknown etiology. They show electroclinical overlap with rolandic epilepsy (the most frequent childhood focal epilepsy) and can be viewed as different clinical expressions of a single pathological entity situated at the crossroads of epileptic, speech, language, cognitive and behavioral disorders. Here we demonstrate that about 20% of cases of LKS, CSWSS and electroclinically atypical rolandic epilepsy often associated with speech impairment can have a genetic origin sustained by de novo or inherited mutations in the GRIN2A gene (encoding the N-methyl-D-aspartate (NMDA) glutamate receptor α2 subunit, GluN2A). The identification of GRIN2A as a major gene for these epileptic encephalopathies provides crucial insights into the underlying pathophysiology.

  5. Infarct topography and hemiparesis profiles with cerebral convexity infarction: the Stroke Data Bank.

    PubMed

    Mohr, J P; Foulkes, M A; Polis, A T; Hier, D B; Kase, C S; Price, T R; Tatemichi, T K; Wolf, P A

    1993-04-01

    For the 183 of 1276 patients in the NINDS Stroke Data Bank with convexity infarction in the middle cerebral artery territory, the size of the infarct did not differ between the two sides but the location of the main site of the infarct differed: on the left side, it was centred in the inferior parietal region, and was mid-frontal on the right. There was a good correlation between infarct size and weakness severity whether estimated by overall motor function on one side, arm, or hand alone. There was a poor correlation, however, for lesion location (lower third, middle third or upper third on either side of the Rolandic fissure) and any of the specific syndromes of focal weakness, no two cases sharing the same lesion for the same syndrome and several cases sharing the same lesion with a different syndrome. The findings indicated a difference in weakness syndromes between the two hemispheres and great individual variation of the acute syndrome caused by a given site of focal infarction along the Rolandic convexity. These variations may explain some of the difficulties showing effects of a given therapeutic agent in studies of acute ischaemic stroke. Large sample sizes will be required for the reliable assessment of any treatment using currently popular clinical stroke scales.

  6. Educational studies of cosmic rays with a telescope of Geiger Müller counters

    NASA Astrophysics Data System (ADS)

    Wibig, T.; Kolodziejczak, K.; Pierzynski, R.; Sobczak, R.

    2006-11-01

    A group of high school students (XII Liceum) in the framework of the Roland Maze Project has built a compact telescope of three Geiger Müller counters. The connection between the telescope and a PC computer was also created and programmed by students involved in the Project. This has allowed students to use their equipment to perform serious scientific measurements concerning the single cosmic ray muon flux at ground level and below. These measurements were then analysed with the programs on the basis of current knowledge on statistics. An overview of the apparatus, methods and results have been presented at several student conferences and recently won the first prize in a national competition for high school students' scientific work. The telescope itself, in spite of its 'scientific' purposes, is built in such a way that it can be hung on a wall in a school physics lab and count muons continuously. This can help to raise in interest in studying physics among others. At present a few (three) groups of young participants of the Roland Maze Project have already built their own telescopes for their schools and some others are working on it. This work is a perfect example of what can be done by young people when respective opportunities are created by more experienced researchers and a little help and advice is given.

  7. Does 48 hours' bed rest influence the outcome of acute low back pain?

    PubMed Central

    Wilkinson, M J

    1995-01-01

    BACKGROUND. Bed rest is a traditional treatment for back pain, yet only in recent years has the therapeutic benefit of this been questioned. AIM. The aim of this pilot study was to ascertain whether or not 48 hours' bed rest had an effect on the outcome of acute low back pain. METHOD. The study was conducted as a randomized controlled trial to compare a prescription of 48 hours' strict bed rest with controls; the control subjects were encouraged to remain mobile and to have no daytime rest. Nine general practitioners from practices in the West Midlands recruited patients in the age range 16-60 years who presented with low back pain of less than seven days' duration, with or without pain radiation. The outcome measures assessed were: change in straight leg raise and lumbar flexion after seven days, Oswestry and Roland-Morris disability scores after seven days and 28 days, and time taken from work. RESULTS. Forty two patients were recruited: 20 were allocated to bed rest and 22 as controls. Compared with the bed rest group the control group had statistically better Roland-Morris scores at day seven (P < 0.05) but not at day 28. At day seven, there were no statistically significant differences between groups in straight leg raise or lumbar flexion measurements although the control group had a better mean lumbar flexion than the bed rest group. The improvement in disability scores at day seven compared with day one was similar for the two groups but more of the control group had fully recovered (defined as scores of one or zero on the Roland-Morris disability scale and five or less on the Oswestry disability scale) by day seven. Remaining mobile did not appear to cause any adverse effects. The number of days lost from work in both groups was equal. A large number of self-remedies and physical therapies were recorded by subjects from both groups. CONCLUSION. The results of this pilot study did not indicate whether bed rest or remaining mobile was superior for the

  8. Cervical spine immobilization in the elderly population

    PubMed Central

    Phan, Kevin; Mobbs, Ralph J.; Wilson, David; Ball, Jonathon

    2016-01-01

    Background Immobilization of the cervical spine is a cornerstone of spinal injury management. In the context of suspected cervical spine injury, patients are immobilized in a ‘neutral position’ based on the head and trunk resting on a flat surface. It is hypothesized that the increased thoracic kyphosis and loss of cervical lordosis seen in elderly patients may require alternative cervical immobilization, compared with the ‘neutral position’. Methods To investigate this, an audit of pan-scan CT performed on consecutive major trauma patients aged over 65 years was carried out over a 6-month period. Utilizing the pan-CT’s localizing scout film, a novel measurement, the ‘chin-brow horizontal’ angle was independently measured by a senior spine surgeon (RJM) and a neurosurgeon (PJR) with the gantry used as a horizontal zero- degree reference. The benefit of the ‘chin-brow horizontal’ angle in the trauma setting is it can be assessed from the bedside whilst the patient is immobilized against a flat surface. Results During the 6-month study period, 58 patients were identified (30 male, 28 female), with an average age of 77.6 years (minimum 65, maximum 97). Results showed that ‘chin-brow horizontal’ angles varied widely, between +15.8 degrees in flexion to −30.5 degrees in extension (mean −12.4 degrees in extension, standard deviation 9.31 degrees. The interobserver correlation was 0.997 (95% CI: 0.995–0.998). Conclusions These findings suggest that, due to degenerative changes commonly seen in elderly patients, the routine use of the ‘neutral position’ adopted for cervical spine immobilization may not be appropriate in this population. We suggest that consideration be taken in cervical spine immobilization, with patients assessed on an individual basis including the fracture morphology, to minimize the risk of fracture displacement and worsened neurological deficit.

  9. Eye-rima oris distance and its relation to the vertical dimension of occlusion measured by two methods: Anthropometric study in a sample of Yemeni dental students

    PubMed Central

    Alhajj, Mohammed Nasser; Khalifa, Nadia; Amran, Abdullah

    2016-01-01

    Objective: This study was conducted to evaluate the relationship between the distance measured from the distal outer of the eye to the parting line of the lips and the occlusal vertical dimension (OVD) measured by two methods. Methods: One hundred and fourteen dental students (76 males and 38 females) were recruited for this study with mean age (22.34 ± 1.83) years. The distance from distal canthus of the eye to rima oris (eye-RO) was compared with two different measurements of the OVD (nasal [N] to gnathion [Gn], and subnasal [Sn] to menton [Me]). All distances were measured using modified digital caliper. Results: Pearson correlation coefficient test for correlations and paired samples t-test for differences were used with a significant level of (P < 0.05). There was a positive significant correlation between the eye-RO distance and the two measurements of the OVD. However, this correlation was stronger between eye-RO and the distance from the tip of the nose to the tip of the chin than that between eye-RO and the distance from the septum of the nose to the under of the chin (r = 0.313 with P = 0.0007, r = 0.296 with P = 0.0014), respectively. Conclusion: The distance from the outer canthus of the eye to the parting of the lips seems to be a reliable method in predicting the OVD and should relate to the distance from the tip of the nose to the tip of the chin. PMID:27011736

  10. Proposed helmet PET geometries with add-on detectors for high sensitivity brain imaging

    NASA Astrophysics Data System (ADS)

    Tashima, Hideaki; Yamaya, Taiga

    2016-10-01

    For dedicated brain PET, we can significantly improve sensitivity for the cerebrum region by arranging detectors in a compact hemisphere. The geometrical sensitivity for the top region of the hemisphere is increased compared with conventional cylindrical PET consisting of the same number of detectors. However, the geometrical sensitivity at the center region of the hemisphere is still low because the bottom edge of the field-of-view is open, the same as for the cylindrical PET. In this paper, we proposed a helmet PET with add-on detectors for high sensitivity brain PET imaging for both center and top regions. The key point is the add-on detectors covering some portion of the spherical surface in addition to the hemisphere. As the location of the add-on detectors, we proposed three choices: a chin detector, ear detectors, and a neck detector. For example, the geometrical sensitivity for the region-of-interest at the center was increased by 200% by adding the chin detector which increased the size by 12% of the size of the hemisphere detector. The other add-on detectors gave almost the same increased sensitivity effect as the chin detector did. Compared with standard whole-body-cylindrical PET, the proposed geometries can achieve 2.6 times higher sensitivity for brain region even with less than 1/4 detectors. In addition, we conducted imaging simulations for geometries with a diameter of 250 mm and with high resolution depth-of-interaction detectors. The simulation results showed that the proposed geometries increased image quality, and all of the add-on detectors were equivalently effective. In conclusion, the proposed geometries have high potential for widespread applications in high-sensitivity, high-resolution, and low-cost brain PET imaging.

  11. Long-term three-dimensional stability of mandibular advancement surgery

    PubMed Central

    Franco, Alexandre A.; Cevidanes, Lucia Helena S.; Phillips, Ceib; Rossouw, Paul Emile; Turvey, Timothy A.; Carvalho, Felipe de Assis R.; de Paula, Leonardo K.; Quintão, Cátia Cardoso A.; Almeida, Marco Antonio O.

    2013-01-01

    PURPOSE To evaluate the three-dimensional changes in the position of the condyles, rami, and chin from 1 to 3 years after mandibular advancement surgery. METHOD This prospective observational study used pre and postoperative CBCT scans of 27 subjects with skeletal Class II jaw relationship and normal or deep overbite. An automatic technique of cranial base superimposition was used to assess positional and/or bone remodeling changes that were visually displayed and quantified using 3D color maps. An analysis of covariance with presence of genioplasty, age at the time of surgery, and sex as explanatory variables was used to estimate and test the adjusted mean changes for each region of interest. RESULTS The chin rotated downward and backwards between the 1 and 3 years post-surgery. Changes ≥ 2mm were observed in 17% of the cases. The mandibular condyles presented displacements and/or bone remodeling ≥ 2mm on the anterior surface (21% of the cases on the left and 13% on the right side), superior surfaces (8% on both sides) and lateral poles (17% on the left and 4% on the right side). The posterior borders of the rami exhibited symmetric lateral or rotational displacements in 4% of the cases. CONCLUSION In the hierarchy of surgical stability, mandibular advancement surgery is considered one of the most stable surgical procedures However, between 1 and 3 years post-surgery approximately 20% of the patients had 2-4 mm changes in the horizontal and vertical chin position, and/or changes in condylar position and adaptive bone remodeling. PMID:23769460

  12. [Microcirculation of optic nerve head and glaucoma].

    PubMed

    Zhang, S H; Zhao, J L; Wu, C

    2016-06-11

    Glaucoma is a leading cause of irreversible blindness world widely. The pathogenesis of glaucoma is still not fully understood. It is proposed that the microcirculation of optic nerve head (ONH) may play an important role in glaucomatous optic neuropathy, but the hypothesis is still lack of direct evidence. In this review, we summarized the technical developments in ONH blood flow examination and findings on relationship between decreased ONH microcirculation and glaucoma. These evidences implicate that damaged ONH microcirculation involves in pathogenesis of glaucoma. (Chin J Ophthalmol, 2016, 52: 466-470). PMID:27373574

  13. Juvenile hyaline fibromatosis: a case report.

    PubMed

    Karaçal, Naci; Gülçelik, Nevzat; Yildiz, Kadriye; Mungan, Sevdegül; Kutlu, Necmettin

    2005-07-01

    Juvenile hyaline fibromatosis ( JHF ) is a rare autosomal recessive disease characterized by papulonodular skin lesions, gingival hyperplasia, joint contractures, and bone lesions. The skin lesions may consist of multiple large tumors, commonly on the scalp and around the neck, and small pearly, pink papules and plaques on the trunk, chin, ears, and around the nostrils. Here, we report a 2-year-old boy with characteristic stiffness of the knees and elbows and pink confluent papules on the paranasal folds, and periauricular and perianal regions. He also had hard nodules all over the scalp and around the mouth, and severe gingival hyperplasia. The lesions were totally excised and clinicopathological diagnosis was JHF.

  14. Helping a boy with chronic medical problems get on friendly terms with his body and puberty.

    PubMed

    Todd, Victoria

    2012-01-01

    "My mom wants me to shave off my facial hair, but I like it. I think it makes me look mature," said sixteen-year-old Alex as he proudly stroked the crop of hairs sprouting from his chin. I was speechless. Why? Because for years I had heard about all the medical things that were wrong with Alex's body. Then, when puberty arrived, his distress about his changing body was intense. So how did psychoanalysis help him get on friendly terms with body changes, even enjoying signs of growing up? We shall see. PMID:26020996

  15. Deep-level diversity and leadership.

    PubMed

    Klein, Kristen M; Wang, Mo

    2010-12-01

    In the special issue on Diversity and Leadership (April 2010), the authors made a strong case for the importance of diversity in workplace leadership, rejected premature declarations that workplace discrimination is obsolete, and called for leadership theories that acknowledge and promote the value of diversity. We appreciate all authors' stressing that the glass ceiling still exists, not only for women but for other historically low-power groups as well. We also agree that modern theories of leadership can benefit immensely from increased participation by scholars and practitioners who are not Western, White, upper-class men (Chin, 2010). PMID:21133527

  16. [Orthognathic surgery: surgical failures and complications].

    PubMed

    Guyot, Laurent

    2016-03-01

    Orthognathic surgery procedures mark the endpoint of lengthy orthodontic-surgical preparations and herald the completion of treatment for patients and their families. The main types of procedure are full maxillary Le Fort I osteotomies, mandibular osteotomies and chin surgery. To ensure a successful outcome, all require a favorable environment and extreme technical skill. But, like all surgical operations, they are also subject to peri- and post-operative complications resulting from treatment hazards or errors. Whatever the cause, surgical complications can entail failures in the management of the malformation. By seeking to understand and analyzing these complications, we can already help to prevent and reduce the contingent risks of failure.

  17. [Research progress of corneal epithelial basal cells and basement membrane].

    PubMed

    Qu, J H; Sun, X G

    2016-09-11

    The cylinder cells at the bottom of corneal epithelial cells are basal cells. Their cytoplasm contains keratin intermediate filament which is important in secretion of basement membrane. Corneal epithelial dysfunction due to diabetes or ocular surgery is intimately related with basal cell abnormality. Corneal epithelial basement membrane is a highly specific extracellular matrix which is made up of lamina lucida and lamina densa. It plays an extremely important role in renewal and restoration. Many ocular abnormalities and diseases have been described to relate to the corneal epithelial basement membrane, such as traumatic recurrent corneal erosion, corneal dystrophy and keratoconus. (Chin J Ophthalmol, 2016, 52: 703-707). PMID:27647251

  18. Pycnodysostosis: A bone dysplasia with unusual oral manifestation.

    PubMed

    Balaji, M S Anandi; Sundaram, R Kanmani Shanmuga; Karthik, Poornima; Asokan, Kannan

    2014-10-01

    Pycnodysostosis, a sclerosing bone dysplasia, is a rare autosomal recessive disorder with an estimated prevalence rate of one in one million. Patients with pycnodyostosis usually have normal intelligence, sexual development and life span. This condition is characterized by increased bone density and fragility along with oral manifestations like malposition teeth, hypoplastic maxilla, receded chin and delayed eruption of permanent teeth with discharging sinuses in the jaws because of poor blood supply. This is one such rare case report of a 47-year-old patient presenting with a complaint of fractured jaw and reviewing the clinical and radiographic characteristics of pycnodysostosis. PMID:25565757

  19. Determination of hydraulic characteristics and yield of aquifers underlying Vekol Valley, Arizona, using several classical and current methods

    USGS Publications Warehouse

    Marie, James R.; Hollett, Kenneth J.

    1996-01-01

    Investigations were conducted in Arizona during the early 1980's to obtain hydrologic data in order to deliver 30,000 acre-feet of water annually to the Ak-Chin Indian Reservation. A recharge experiment produced infiltration rates for an ephemeral stream channel that ranged from 0.64 to 1.09 cubic feet per second per 1,000 feet of channel length. Water moved vertically through the 330-foot-thick unsaturated zone to the water table in less than 5 days.

  20. [Insufficient diagnostics in a patient with a fracture of the mandibular collum].

    PubMed

    Valstar, M H; Jaspers, G W; de Lange, J

    2013-03-01

    A 13-year-old boy was presented to oral and maxillofacial surgeon with chin and preauricular pain after afallfrom his skateboard. A panoramic radiograph did not show any indication of a fracture of the mandibular collum. Two weeks later, the boy was referred by his orthodontist to the department of Oral and Maxillofacial Surgery of a medical centre in connection with a relapse ofa class III malocclusion despite a recently completed treatment of that problem. A computertomogram displayed a fracture of the mandibular collum. In case afracture of the mandibular collum is suspected, imaging from 2 directions is always required.

  1. Micropuncture needles combined with ultrasound guidance for unusual central venous cannulation: desperate times call for desperate measures--a new trick for old anesthesiologists.

    PubMed

    Castillo, Daniel; McEwen, Dan S; Young, Lyle; Kirkpatrick, John

    2012-03-01

    Central vascular access can be a very challenging task in patients with skeletal deformities such as ankylosing spondylitis, kyphosis, and chin-on-chest deformity. The use of traditional methods of accessing the central venous circulation in these patients can require multiple attempts and may lead to significant complications such as bleeding, pneumothorax, and vascular injury. Ultrasound-guided central venous access has become a very common procedure in the United States and Europe; its efficacy and safety have been demonstrated, and together with the use of micropuncture needles, the technique can facilitate central venous access in complicated cases.

  2. Dermatoses of the neck affecting violin and viola players ("fiddler's neck", and contact dermatitis).

    PubMed

    Tennstedt, D; Cromphaut, P; Dooms-Goossens, A; Lachapelle, J M

    1979-01-01

    Skin lesions occurring on the neck of violin or viola players are described, in the light of two personal observations. The lesions can be divided into two types: 1. Lesions described as "fiddler's neck", i.e. an area of erythematous, sometimes pigmented or scaly lichenification on the left side of the neck, just below the angle of the jaw, where the chin rest of the instrument is in contact with the skin. Histopathologic features of the lesions are described. 2. Allergic contact dermatitis to wooden or metallic parts of the violin. The recent literature is reviewed.

  3. Misidentification by wild rabbits,Oryctolagus cuniculus, of group members carrying the odor of foreign inguinal gland secretion : I. Experiments with all-male groups.

    PubMed

    Hesterman, E R; Mykytowycz, R

    1982-02-01

    To demonstrate that the inguinal gland odor conveys information on the identity of individuals, 60 male, wild-type rabbits,Oryctolagus cuniculus, living in groups of three in outdoor pens, were used in 120 tests. Members of the groups smeared with the inguinal gland secretion from unfamiliar rabbits were attacked by their penmates. In contrast the odors of chin gland secretions and urine of strange rabbits and of a commercial perfume did not cause serious disruption to the social relationships within the groups.

  4. Management of congenital muscular torticollis in a child: a case report and review.

    PubMed

    Ta, Jennifer H; Krishnan, Miguel

    2012-11-01

    Congenital muscular torticollis is a condition in which the sternocleidomastoid muscle is shortened on the involved side, leading to an ipsilateral tilt of the head and a contralateral rotation of the face and chin. Most of these patients present in infancy and are successfully treated with physical therapy. Occasionally, patients present in childhood at which time conservative management is rarely successful. Here we present a child with torticollis who was successfully managed with a unipolar release of the sternocleidomastoid. We then review the epidemiology, proposed etiologies, and various treatment options for torticollis and their rates of success.

  5. Congenital muscular torticollis.

    PubMed

    Nilesh, Kumar; Mukherji, Srijon

    2013-07-01

    Congenital muscular torticollis (CMT) is a rare congenital musculoskeletal disorder characterized by unilateral shortening of the sternocleidomastoid muscle (SCM). It presents in newborn infants or young children with reported incidence ranging from 0.3% to 2%. Owing to effective shortening of SCM on the involved side there is ipsilateral head tilt and contralateral rotation of the face and chin. This article reports a case of CMT in a 3½-year-old male child successfully managed by surgical release of the involved SCM followed by physiotherapy.

  6. Congenital muscular torticollis

    PubMed Central

    Nilesh, Kumar; Mukherji, Srijon

    2013-01-01

    Congenital muscular torticollis (CMT) is a rare congenital musculoskeletal disorder characterized by unilateral shortening of the sternocleidomastoid muscle (SCM). It presents in newborn infants or young children with reported incidence ranging from 0.3% to 2%. Owing to effective shortening of SCM on the involved side there is ipsilateral head tilt and contralateral rotation of the face and chin. This article reports a case of CMT in a 3½-year-old male child successfully managed by surgical release of the involved SCM followed by physiotherapy. PMID:24205484

  7. PubMed Central

    ALDIANO, C.; PENTENERO, M.; BERRONE, S.

    2015-01-01

    SUMMARY This study describes an unusual case of mandibular asymmetry after fibula free flap reconstruction in a young man following major facial trauma that was corrected using a custom-made polyetheretherketone prosthesis. There is little information in the literature on the use of alloplasts to correct mandibular asymmetry as interest in 'aesthetic re-modelling' has traditionally focused on nasal, zygomatic and chin regions. This report demonstrates that this technique can be used successfully to address selected cases of mandibular asymmetry. PMID:26824216

  8. Hypersonic airbreathing missile concepts under study at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Hunt, J. L.; Johnston, P. J.; Cubbage, J. M.; Dillon, J. L.; Richie, C. B.; Marcum, D. C., Jr.; Carlson, C. H.

    1982-01-01

    The design and performance of several tactical and strategic hypersonic airbreathing missile concepts under study at the NASA Langley Research Center are discussed from an evolutionary perspective. A mid- and chin inlet missile design, constrained to the Navy's vertical box launcher, was investigated; a performance comparison is presented that is favorable to the mid-inlet approach. Parasol wing, confined flow field, and spatula-like cruise missile configurations were examined with strategic applications in mind. The preliminary results are encouraging with respect to aerodynamic and volumetric efficiency and choice of engine integration schemes.

  9. Revisiting Deng et al.'s Multiparty Quantum Secret Sharing Protocol

    NASA Astrophysics Data System (ADS)

    Hwang, Tzonelih; Hwang, Cheng-Chieh; Yang, Chun-Wei; Li, Chuan-Ming

    2011-09-01

    The multiparty quantum secret sharing protocol [Deng et al. in Chin. Phys. Lett. 23: 1084-1087, 2006] is revisited in this study. It is found that the performance of Deng et al.'s protocol can be much improved by using the techniques of block-transmission and decoy single photons. As a result, the qubit efficiency is improved 2.4 times and only one classical communication, a public discussion, and two quantum communications between each agent and the secret holder are needed rather than n classical communications, n public discussions, and 3n/2 quantum communications required in the original scheme.

  10. Paraliparis hawaiiensis, a new species of snailfish (Scorpaeniformes: Liparidae) and the first described from the Hawaiian Archipelago.

    PubMed

    Stein, D L; Drazen, J C

    2014-05-01

    Paraliparis hawaiiensis n.sp. is described from the north-western Hawaiian Islands from two specimens collected at 2196 and 3055 m. It differs from other North Pacific Ocean species in its chin pore arrangement, tooth pattern and body proportions. Although liparid specimens have previously been collected from Hawaii, they were undescribed and are now lost. Therefore, this is the first liparid species described from the archipelago. In situ photographs of Hawaiian snailfishes are also shown and discussed here. PMID:24697612

  11. Nonadiabatic production of spinor condensates with a QUIC trap

    NASA Astrophysics Data System (ADS)

    Zhang, Peng; Xu, Zhan; You, Li

    2006-05-01

    A recent experiment [Xiu-Quan Ma et al., Chin. Phys. Lett. 22, 1106 (2005)] reported the observation of a multi-component spinor condensate when the magnetic field of a QUIC trap containing a spin polarized condensate was switched off. Our theoretical study show that this phenomena can be described within a general framework of the nonadiabatic Landau-Zener transition theory. We will discuss the population transfers at the zero field level crossing for this interesting case involving more than two levels, and provide a detailed understanding of the relevant nonadiabatic behavior.

  12. Deep-level diversity and leadership.

    PubMed

    Klein, Kristen M; Wang, Mo

    2010-12-01

    In the special issue on Diversity and Leadership (April 2010), the authors made a strong case for the importance of diversity in workplace leadership, rejected premature declarations that workplace discrimination is obsolete, and called for leadership theories that acknowledge and promote the value of diversity. We appreciate all authors' stressing that the glass ceiling still exists, not only for women but for other historically low-power groups as well. We also agree that modern theories of leadership can benefit immensely from increased participation by scholars and practitioners who are not Western, White, upper-class men (Chin, 2010).

  13. Partial deletion of long arm of chromosome 11[del(11)(q23)]: Jacobsen syndrome. Two new cases and review of the clinical findings.

    PubMed Central

    Schinzel, A; Auf der Maur, P; Moser, H

    1977-01-01

    Two cases, a boy and a girl, with the 11q-(Jacobsen) syndrome are reported. Findings common to both and typical for this chromosome aberration include a narrow protruding forehead, hypertelorism, non-horizontal position of the eyes, ptosis, strabismus, broad root, and short upturned tip of thenose, carp mouth, receding chin, misshapen ears, simian creases, and severe mental retardation. In addition, one patient had pyloric stenosis and an inguinal hernia. Growth retardation and microcephaly were not found in either of them. The karyotypes revealed de novo-deletions of the long arm of one chromosome 11,del(11)(q23). Images PMID:604495

  14. Epithelial and Fibrous Hyperplasia: An Oral Manifestation of Tuberous Sclerosis Complex. A Case Study.

    PubMed

    Mbibi, Sandra U; Segelnick, Stuart L; Weinberg, Mea A

    2015-01-01

    The authors present a case study of a 13-year-old female with a past medical history of tuberous sclerosis complex (TSC), an autosomal dominant disorder. It usually presents with a triad of epilepsy, mental deficiency and facial angiofibromas that are often distributed around the nose, cheek and chin, and are frequently shaped like butterfly wings. In addition, oral manifestations include gingival enlargement and developmental enamel pitting on the facial aspect of the anterior permanent dentition in 50% to 100% of patients. The patient's chief complaint was gingival enlargement and gingival bleeding. The histology of the excised gingival tissue revealed epithelial and fibrous hyperplasia, consistent with TSC.

  15. Cryptanalysis and Improvement on "Robust EPR-Pairs-Based Quantum Secure Communication with Authentication Resisting Collective Noise"

    NASA Astrophysics Data System (ADS)

    Yue, Qiu-Ling; Yu, Chao-Hua; Liu, Bin; Wang, Qing-Le

    2016-05-01

    Recently, Chang et al. [Sci Chin-Phys Mech Astron. 57(10), 1907-1912, 2014] proposed two robust quantum secure communication protocols with authentication based on Einstein-Podolsky-Rosen (EPR) pairs, which can resist collective noise. In this paper, we analyze the security of their protocols, and show that there is a kind of security flaw in their protocols. By a kind of impersonation attack, the eavesdropper can obtain half of the message on average. Furthermore, an improved method of their protocols is proposed to close the security loophole.

  16. Acute, flaccid quadriplegia in three cats with suspected coral snake envenomation.

    PubMed

    Chrisman, C L; Hopkins, A L; Ford, S L; Meeks, J C

    1996-01-01

    Three cats were evaluated for acute, ascending, flaccid quadriplegia; depression; and reduced nociception. Complete or partial neuromuscular junction blockade was found on nerve stimulation studies during electromyographic examinations. Two of the cases had wounds on the chin or paw compatible with coral snake bites. Although a coral snake was found in only one case, coral snake envenomation was suspected because potential for exposure, clinical signs, and electrodiagnostic findings were similar to dogs reported with this condition and to cats with tiger snake envenomation. Only one case received coral snake antivenin. All cases recovered within seven-to-10 days.

  17. Osteotomy and osteosynthesis in complex segmental genioplasty with double surgical guide

    PubMed Central

    Assis, Adriano; Olate, Sergio; Asprino, Luciana; de Moraes, Márcio

    2014-01-01

    Chin osteotomy is used in esthetic and functional procedure; genioplasty shows different surgical options as lineal osteotomy, curved osteotomy, segmental osteotomy and others for different conditions of the face. This communication shows the use of two surgical guides used in a patient with extremely facial asymmetry; the surgical plan was realized in a stereolithographic biomodel. The first surgical guide was used for osteotomy and the second surgical guide was used for putting the plate, previously bent, and for segmented osteotomy in the planned position on the biomodel; this technique showed adequate adaptation and security in this extremely asymmetric case. The potential use of this surgical guide was discussed. PMID:24995074

  18. [Is glaucoma a mitochondrial neurodegenerative disease].

    PubMed

    Zhang, Z; Ma, J M; Wang, N L

    2016-09-11

    The retinal ganglion cell, due to peculiar structural and energetic constraints, appears acutely susceptible to mitochondrial dysfunction. Emerging evidence suggests that changes in the mitochondrial DNA(mtDNA)and in nuclear DNA genes that encode mitochondrial proteins may influence mitochondrial structure and function and, therefore, contribute to the pathogenesis of primary open angle glaucoma. As the main glaucoma risk factors are elevated intraocular pressure and older age, we discuss their relationship with mitochondrial dysfunction. If the contribution of mitochondrial dysfunction to glaucoma pathogenesis is further established, emerging therapies aiming to optimize mitochondrial function represent potential clinical treatments. (Chin J Ophthalmol, 2016, 52: 714-717). PMID:27647253

  19. Surgical orthodontic correction of mandibular laterognathism

    PubMed Central

    Singh, Harpreet; Srivastava, Dhirendra; Kapoor, Pranav; Sharma, Poonam

    2016-01-01

    This case report describes the successful treatment of a patient with mandibular laterognathism and associated facial asymmetry with combined surgical orthodontic approach. After 7 months of presurgical orthodontic treatment, intraoral vertical ramus osteotomy, and straightening genioplasty were performed as two step surgeries to reposition the deviated mandible and chin, respectively. The total active treatment period was 14 months. After surgical orthodontic treatment, significant improvement in occlusion, masticatory function, and facial appearance was discernible. Posttreatment records at 3 years showed stable results with good occlusion. PMID:27127755

  20. Comparison of eye movements over faces in photographic positives and negatives.

    PubMed

    Luria, S M; Strauss, M S

    1978-01-01

    Eye movements were recorded while subjects viewed ordinary portraits and photographic negatives of those portraits. Under both conditions they first studied sixteen portraits and then tried to decide which of forty-eight portraits they had just seen. They made more errors of recognition while viewing negatives, and their fixation patterns were significantly altered: there was a decrease in the percentage of fixations directed to the eyes, nose, and mouth, and an increase for such details as the ears, cheeks, chin, cap, and necktie. There was also a decrease in the ratio of fixations to the most fixated detail compared to the least fixated detail. PMID:693234

  1. Comparison of eye movements over faces in photographic positives and negatives.

    PubMed

    Luria, Saul M; Strauss, Mark S

    2013-01-01

    Eye movements were recorded while subjects viewed ordinary portraits and photographic negatives of those portraits. Under both conditions they first studied sixteen portraits and then tried to decide which of forty-eight portraits they had just seen. They made more errors of recognition while viewing negatives, and their fixation patterns were significantly altered: there was a decrease in the percentage of fixations directed to the eyes, nose, and mouth, and an increase for such details as the ears, cheeks, chin, cap, and necktie. There was also a decrease in the ratio of fixations to the most fixated detail compared to the least fixated detail. PMID:24601026

  2. [The advances of suppression in research of amblyopia].

    PubMed

    Liu, S; Liu, H

    2016-04-11

    Suppression that is the result of interocular competition is an important machanism of amblyopia. The imbalance of suppression may lead the consequence to amblyopia. In the early study, researchers had raised the theory of II. Quadratic Summation which had revealed the relationship of interocular interaction and suppression. In some basic researches, other studies had showed the most possible anatomic location of suppression. Recently, researchers found a new method to quantify the interocular suppression named the noise model. Further studies found a novel disinhibition therapy to treat amblyopia. We summarized the research advances in suppression and disinhibition treatment in amblyopia. (Chin J Ophthalmol, 2016, 52: 305-308). PMID:27094069

  3. A fatality and the American mountain lion: bite mark analysis and profile of the offending lion.

    PubMed

    Rollins, C E; Spencer, D E

    1995-05-01

    Attacks on humans by mountain lions have been infrequent in the history of the United States. Of the 64 authenticated attacks since 1890 in North America, there have been 13 fatalities. This paper reports a case of an adult mountain lion which attacked and killed a female jogger during the spring of 1994 in California. The lion left an imprint of its teeth on the victim's chin. The authors used this bite mark to aid authorities in profiling the approximate age and gender of the attacking animal. The authors subsequently utilized bite mark analysis to establish that the lion actually responsible for the attack had been removed from the area. PMID:7782754

  4. Three-dimensional assessment of mandibular advancement 1 year after surgery

    PubMed Central

    de Assis Ribeiro Carvalho, Felipe; Cevidanes, Lucia Helena Soares; Motta, Alexandre Trindade Simões da; de Oliveira Almeida, Marco Antonio; Phillips, Ceib

    2010-01-01

    Introduction This prospective observational study evaluated changes in the 3-dimensional position and remodeling of the mandibular rami, condyles, and chin at splint removal and 1 year after mandibular advancement surgery. Methods Presurgery, splint removal (4–6 weeks postsurgery), and 1-year postsurgery cone-beam computed tomography scans of 27 subjects were used. Superimposition on the cranial base was used to assess positional or remodeling changes in the anatomic regions of interest. Surface distance displacements were visually displayed and quantified by 3-dimensional color maps. A 1-sample t test was used to assess the average postsurgical changes of each region of interest. The level of significance was set at 0.05. Results After antero-inferior chin displacement with surgery (mean, 6.81 ± 3.2 mm at splint removal), the average 1-year post-surgery displacement was not statistically significant (P = 0.44). Postsurgical adaptations greater than 2 mm were observed in 48% of the patients: 16% with an additional anterior-inferior displacement of the chin of 2 to 4 mm, and 4% with ≥4 mm; 20% had postero-superior movement of 2 to 4 mm, and 8% had postero-superior movement of ≥4 mm. The condyles tended to move, on average, ≤2 mm supero-posteriorly with surgery, and this small positional displacement was maintained 1 year postsurgery (right condyle, P = 0.58; left, P = 0.88). The rami exhibited outward (lateral) movements with surgery, with greater displacement of the inferior part of the rami (≥2 mm in 65% of the subjects). This torque of the ramus with surgery was stable 1 year postsurgery. Conclusions Three-dimensional assessment of skeletal changes with mandibular advancement surgery shows that nearly half of the patients have >2 mm change in chin position from splint removal to the 1-year follow-up, with approximately equal chances of anterior and posterior movement. Torque of the rami usually occurs with mandibular advancement surgery. PMID:20381760

  5. Neutrino Tunneling from NUT Kerr Newman de Sitter Black Hole

    NASA Astrophysics Data System (ADS)

    Yang, Nan; Yang, Juan; Li, Jin

    2013-08-01

    In this paper, the method of semi-classical is applied to explore the Hawking radiation of a NUT-Kerr-Newman de Sitter Black Hole from tunneling point of view. The Hamilton-Jacobi equation in NUT-Kerr-Newman de Sitter space time is derived by the method presented by Lin and Yang (Chin. Phys. B, 20:110403, 2011). We obtain the Hawking temperatures at the event horizon and cosmological horizon and we also obtain the tunneling probability of neutrino following the semi-classical quantum equation. The results show the common features of NUT-Kerr-Newman de Sitter Black Hole.

  6. Cryptanalysis and Improvement on "Robust EPR-Pairs-Based Quantum Secure Communication with Authentication Resisting Collective Noise"

    NASA Astrophysics Data System (ADS)

    Yue, Qiu-Ling; Yu, Chao-Hua; Liu, Bin; Wang, Qing-Le

    2016-10-01

    Recently, Chang et al. [Sci Chin-Phys Mech Astron. 57(10), 1907-1912, 2014] proposed two robust quantum secure communication protocols with authentication based on Einstein-Podolsky-Rosen (EPR) pairs, which can resist collective noise. In this paper, we analyze the security of their protocols, and show that there is a kind of security flaw in their protocols. By a kind of impersonation attack, the eavesdropper can obtain half of the message on average. Furthermore, an improved method of their protocols is proposed to close the security loophole.

  7. Maritime Aerosol Network (MAN) as a Component of AERONET

    NASA Technical Reports Server (NTRS)

    Smirnov, A.; Holben, B. N.; Slutsker, I.; Giles, D. M.; McClain, C. R.; Eck, T. F.; Sakerin, S. M.; Macke, A.; Croot, P.; Zibordi, G.; Quinn, P. K.

    2008-01-01

    The World Ocean produces a large amount of natural aerosols that have all impact on the Earth's albedo and climate. Sea-salt is the major contributor to aerosol optical depth over the oceans. [Mahowald et al. 2006; Chin et al. 2002; Satheesh et al. 1999; Winter and Chylek, 1997] and therefore affects the radiative balance over the ocean through the direct [Haywood et al. 1999] and indirect aerosol effect [O'Dowd et al. 1999]. Aerosols over the oceans (produced marine and advected from land sources) are important for various atmospheric processes [Lewis and Schwartz, 2004] and remote sensing studies [Gordon, 1997].

  8. Pycnodysostosis: A bone dysplasia with unusual oral manifestation

    PubMed Central

    Balaji, M S Anandi; Sundaram, R Kanmani Shanmuga; Karthik, Poornima; Asokan, Kannan

    2014-01-01

    Pycnodysostosis, a sclerosing bone dysplasia, is a rare autosomal recessive disorder with an estimated prevalence rate of one in one million. Patients with pycnodyostosis usually have normal intelligence, sexual development and life span. This condition is characterized by increased bone density and fragility along with oral manifestations like malposition teeth, hypoplastic maxilla, receded chin and delayed eruption of permanent teeth with discharging sinuses in the jaws because of poor blood supply. This is one such rare case report of a 47-year-old patient presenting with a complaint of fractured jaw and reviewing the clinical and radiographic characteristics of pycnodysostosis. PMID:25565757

  9. Atypical rosacea in a male patient: case study.

    PubMed

    Debroy Kidambi, A; Tiffin, N J; Ramsay, H M

    2016-01-01

    Rosacea fulminans is a rare disorder of unknown cause, almost exclusively affecting women. There are only a few reported cases in men. The condition is characterized by the abrupt onset of pustules and nodules predominantly affecting the cheeks or chin without any systemic upset. We report the case of a 37-year-old man who presented with papulopustules, predominantly localized to his nose. Histopathological features were consistent with rosacea fulminans. The patient was managed with treatments including oral prednisolone, isotretinoin, and trimethioprim. PMID:27267199

  10. Frontonasal dysplasia, macroblepharon, eyelid colobomas, ear anomalies, macrostomia, mental retardation and CNS structural anomalies: defining the phenotype.

    PubMed

    Guion-Almeida, M L; Richieri-Costa, A

    2001-04-01

    We report a Brazilian boy, born to normal and nonconsanguineous parents showing, among other signs, brachycephaly, a wide forehead, a widow's peak, hypertelorism, wide palpebral fissures with multiple eyelid colobomas, a broad nasal root, a long philtrum, macrostomia, prominent lips, a high arched palate, a midline alveolar cleft, a small and grooved chin, ear anomalies, structural anomaly of the corpus callosum, and mental retardation. To our knowledge this additional patient defines a particular clinical condition previously reported [Guion-Almeida M.L. Richieri-Costa A. (1999) Clinical Dysmorphol 8;1-4; Masuno M. et al. (2000) Clin Dysmorphol 9:59-60].

  11. Functional and structural balances of homologous sensorimotor regions in multiple sclerosis fatigue.

    PubMed

    Cogliati Dezza, I; Zito, G; Tomasevic, L; Filippi, M M; Ghazaryan, A; Porcaro, C; Squitti, R; Ventriglia, M; Lupoi, D; Tecchio, F

    2015-03-01

    Fatigue in multiple sclerosis (MS) is a highly disabling symptom. Among the central mechanisms behind it, an involvement of sensorimotor networks is clearly evident from structural and functional studies. We aimed at assessing whether functional/structural balances of homologous sensorimotor regions-known to be crucial for sensorimotor networks effectiveness-decrease with MS fatigue increase. Functional connectivity measures at rest and during a simple motor task (weak handgrip of either the right or left hand) were derived from primary sensorimotor areas electroencephalographic recordings in 27 mildly disabled MS patients. Structural MRI-derived inter-hemispheric asymmetries included the cortical thickness of Rolandic regions and the volume of thalami. Fatigue symptoms increased together with the functional inter-hemispheric imbalance of sensorimotor homologous areas activities at rest and during movement, in absence of any appreciable parenchymal asymmetries. This finding supports the development of compensative interventions that may revert these neuronal activity imbalances to relieve fatigue in MS.

  12. Session: Program Review X Wrap-Up

    SciTech Connect

    1992-01-01

    This wrap-up session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of Closing Remarks by Roland R. Kessler and six NGA Industry Critique Panel presentations: ''Summary of Comments on DOE-Industry Cooperation by Geothermal Industry Panel'' by James B. Koenig, GeothermEx, Inc.; ''NGA Industry Critique of the Exploration Component'' by Joe L. Iovenitti, Weiss Associates; ''Critique of Drilling Research'' by Jerry Hamblin, UNOCAL Geothermal; ''Critique Panel Comments on Reservoir Engineering, DOE Geothermal Technology Development'' by Dennis Kaspereit, California Energy Company, Inc.; ''DOE Geothermal Program Review - Critique on Production'' by Douglas B. Jung, Two-Phase Engineering and Research; ''Comments on the DOE Hydrothermal Energy Conversion R&D Program'' by David L. Mendive, Geothermal Development Associates.

  13. At Home in the Universe

    NASA Astrophysics Data System (ADS)

    Wheeler, John A.

    Colleague and confidant of Einstein and Bohr and pioneer of nuclear fission -- John A. Wheeler is one of our most original and profound thinkers. In engaging essays formed of reminiscence, science, and conjecture, Wheeler writes of debates and discussions with Bohr, long talks with Einstein in his study at Princeton, and the eloquence and nobility of Hermann Weyl. With simple delight in "the machinery of existence" Wheeler exudes an enthusiasm that illuminates this collection. John Wheeler is one of the 20th century's most notable nuclear physicists and relativity theorists. In addition, he has played a leading role in research on pulsars, black holes, and nuclear reactor safety. Dr. Wheeler is Jan and Roland Blumberg Professor Emeritus at the University of Texas, Austin and Joseph Henry Professor of Physics Emeritus at Princeton University.

  14. Langevin Simulation of Microstructure in Martensitic Transformations

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Lookman, T.; Shenoy, S. R.; Saxena, A.; Bishop, A. R.

    1996-03-01

    We present a dynamical model to simulate microstructure in martensitic transformations within the context of shape memory alloys. The Hamiltonian of the system includes a triple-well potential (φ^6 model) in local shear strain, (2) strain gradient terms up to second order in strain and fourth order in gradient, and (3) all symmetry allowed compositional fluctuation induced strain gradient terms. We show the formation of twinned martensite below the transformation temperature and tweed precursors above the transformation temperature, as well as indications of hierarchical structures near the habit plane. These phases result from a competition between short range attraction and long range elastic repulsive forces. The long range interaction is incorporated via Fourier spectral methods as discussed by C. Roland and R.C.Desai [Phys. Rev. B 42, 6658 (1990)].

  15. International Program and Local Organizing Committees

    NASA Astrophysics Data System (ADS)

    2012-12-01

    International Program Committee Dionisio Bermejo (Spain) Roman Ciurylo (Poland) Elisabeth Dalimier (France) Alexander Devdariani (Russia) Milan S Dimitrijevic (Serbia) Robert Gamache (USA) Marco A Gigosos (Spain) Motoshi Goto (Japan) Magnus Gustafsson (Sweden) Jean-Michel Hartmann (France) Carlos Iglesias (USA) John Kielkopf (USA) John C Lewis (Canada) Valery Lisitsa (Russia) Eugene Oks (USA) Christian G Parigger (USA) Gillian Peach (UK) Adriana Predoi-Cross (Canada) Roland Stamm (Germany) Local Organizing Committee Nikolay G Skvortsov (Chair, St Petersburg State University) Evgenii B Aleksandrov (Ioffe Physico-Technical Institute, St Petersburg) Vadim A Alekseev (Scientific Secretary, St Petersburg State University) Sergey F Boureiko (St.Petersburg State University) Yury N Gnedin (Pulkovo Observatory, St Petersburg) Alexander Z Devdariani (Deputy Chair, St Petersburg State University) Alexander P Kouzov (Deputy Chair, St Petersburg State University) Nikolay A Timofeev (St Petersburg State University)

  16. ESA Mission ROSETTA Will Probe for Chirality of Cometary Amino Acids

    NASA Astrophysics Data System (ADS)

    Thiemann, Wolfram H.-P.; Meierhenrich, Uwe

    2001-02-01

    New crucial theoretical investigations on the origin of biomolecular chirality are reviewed briefly. With the goal to investigate these theories our team is going to perform the `chirality-experiment' in the near future with cometary matter. In 2012 the robotical lander RoLand will detach from the orbiter of the ROSETTA spacecraft and set down on the surface of comet 46P/Wirtanen in order to separate and identify cometary organic compounds via GC-MS in situ. Chiral organics will be separated into their enantiomers by application of 3 capillary columns coated with different kinds of stationary phases. Non-volatile compounds like amino acids will be derivatized in especially developed gas phase alkylation steps avoiding reactions in the liquid phase. The results of these preliminary gas phase reactions are presented in this article.

  17. Europäisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung

    NASA Astrophysics Data System (ADS)

    Jobst, Solvejg

    2005-11-01

    EUROPEAN CONSCIOUSNESS: TOWARDS DEFINING A COMPLEX CONCEPT AND ITS EDUCATIONAL SIGNIFICANCE - The present study aims at a definition of `European consciousness'. In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmüller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain identification structures and social perspectives, can take such distinct forms of moral consciousness as `Eurocentrism', `European patriotism', or `reflective European consciousness'. Making reference to Wolfgang Klafki's notion of general education, it is finally argued that the emancipatory contribution of schooling to greater European integration consists in mediating precisely this last way of thinking.

  18. Airborne Wind Shear Detection and Warning Systems. Second Combined Manufacturers' and Technologists' Conference, part 2

    NASA Technical Reports Server (NTRS)

    Spady, Amos A., Jr. (Compiler); Bowles, Roland L. (Compiler); Schlickenmaier, Herbert (Compiler)

    1990-01-01

    The Second Combined Manufacturers' and Technologists' Conference was hosted jointly by NASA Langley (LaRC) and the Federal Aviation Administration (FAA) in Williamsburg, Virginia, on October 18 to 20, 1988. The meeting was co-chaired by Dr. Roland Bowles of LaRC and Herbrt Schlickenmaier of the FAA. The purpose of the meeting was to transfer significant, ongoing results gained during the second year of the joint NASA/FAA Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements.

  19. Airborne Wind Shear Detection and Warning Systems. Fourth Combined Manufacturers' and Technologists' Conference, part 2

    NASA Technical Reports Server (NTRS)

    Vicroy, Dan D. (Compiler); Bowles, Roland L. (Compiler); Passman, Robert H. (Compiler)

    1992-01-01

    The Fourth Combined Manufacturers' and Technologists' Conference was hosted jointly by NASA Langley Research Center (LaRC) and the Federal Aviation Administration (FAA) in Williamsburg, Virginia, on April 14-16, 1992. The meeting was co-chaired by Dr. Roland Bowles of LaRC and Bob Passman of the FAA. The purpose of the meeting was to transfer significant ongoing results of the NASA/FAA Joint Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements. The present document has been compiled to record the essence of the technology updates and discussions which follow each.

  20. Benign nocturnal alternating hemiplegia of childhood: two cases with positive evolution.

    PubMed

    Villéga, Frédéric; Picard, Fabienne; Espil-Taris, Caroline; Husson, Marie; Michel, Véronique; Pedespan, Jean-Michel

    2011-06-01

    Benign nocturnal alternating hemiplegia (BNAH) of childhood is distinct from the classic form of malignant alternating hemiplegia of childhood [1]. It is characterized by hemiplegic attacks occurring exclusively during sleep [2]. It can be misdiagnosed as migraine, nocturnal frontal lobe epilepsy, benign rolandic epilepsy, Panayiotopoulos syndrome, or sleep-related movement disorder [1-4]. Only nine patients have been described to date, with typically, a normal development [1,5-7]. In order to insist about the benignity of the affection, we report two cases: a new three-year-old boy suffering from BNAH and a patient already published to show positive evolution at fourteen years of age. BNAH is a rare disorder but may be underdiagnosed. Making an early diagnosis can help to describe to the parents the good prognosis without treatment. PMID:20817433

  1. Five benefits of call recording for medical practices.

    PubMed

    Murphy, Roland

    2010-01-01

    Despite documentation's essential positioning in medical practices of all sizes and specialties, one aspect of patient and insurance provider interaction remains overlooked in the majority of practices: telephone-based communication. In many cases, patient and payment information exchanged via telephone is logged with little more than a note typed or written in the patient file. This leads to "he said/she said" disagreements with regard to patient service, consultations, and coding; reduced payments from insurance providers; incomplete patient records; liability exposure; and a host of other problems. In this article, call recording professional Roland Murphy explains how a call recording solution can fill the gaps in documentation, increase practice revenues, and improve patient care without excessive investment costs and while protecting patient confidentiality. PMID:20480782

  2. Reduced fractional anisotropy in the anterior corpus callosum is associated with reduced speech fluency in persistent developmental stuttering.

    PubMed

    Civier, Oren; Kronfeld-Duenias, Vered; Amir, Ofer; Ezrati-Vinacour, Ruth; Ben-Shachar, Michal

    2015-04-01

    Developmental stuttering is a speech disorder that severely limits one's ability to communicate. White matter anomalies were reported in stuttering, but their functional significance is unclear. We analyzed the relation between white matter properties and speech fluency in adults who stutter (AWS). We used diffusion tensor imaging with tract-based spatial statistics, and examined group differences as well as correlations with behavioral fluency measures. We detected a region in the anterior corpus callosum with significantly lower fractional anisotropy in AWS relative to controls. Within the AWS group, reduced anisotropy in that region is associated with reduced fluency. A statistically significant interaction was found between group and age in two additional regions: the left Rolandic operculum and the left posterior corpus callosum. Our findings suggest that anterior callosal anomaly in stuttering may represent a maladaptive reduction in interhemispheric inhibition, possibly leading to a disadvantageous recruitment of right frontal cortex in speech production.

  3. Historical Photogrammetry: Bird's Paluxy River Dinosaur Chase Sequence Digitally Reconstructed as It Was prior to Excavation 70 Years Ago

    PubMed Central

    Falkingham, Peter L.; Bates, Karl T.; Farlow, James O.

    2014-01-01

    It is inevitable that some important specimens will become lost or damaged over time, conservation is therefore of vital importance. The Paluxy River dinosaur tracksite is among the most famous in the world. In 1940, Roland T. Bird described and excavated a portion of the site containing associated theropod and sauropod trackways. This excavated trackway was split up and housed in different institutions, and during the process a portion was lost or destroyed. We applied photogrammetric techniques to photographs taken by Bird over 70 years ago, before the trackway was removed, to digitally reconstruct the site as it was prior to excavation. The 3D digital model offers the opportunity to corroborate maps drawn by R.T. Bird when the tracksite was first described. More broadly, this work demonstrates the exciting potential for digitally recreating palaeontological, geological, or archaeological specimens that have been lost to science, but for which photographic documentation exists. PMID:24695537

  4. Neural mechanisms underlying auditory feedback control of speech.

    PubMed

    Tourville, Jason A; Reilly, Kevin J; Guenther, Frank H

    2008-02-01

    The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 136 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech.

  5. And to end on a poetic note: Galen’s authorial strategies in the pharmacological books

    PubMed Central

    Totelin, Laurence M.V.

    2012-01-01

    This paper examines the authorial strategies deployed by Galen in his two main pharmacological treatises devoted to compound remedies: Composition of Medicines according to Types and Composition of Medicines according to Places. Some of Galen’s methods of self assertion (use of the first person; writing of prefaces) are conventional. Others have not received much attention from scholars. Thus, here, I examine Galen’s borrowing of his sources’ ‘I’; his use of the phrase ‘in these words’; and his recourse to Damocrates’ verse to conclude pharmacological books. I argue that Galen’s authorial persona is very different from that of the modern author as defined by Roland Barthes. Galen imitates and impersonates his pharmacological sources. This re-enactment becomes a way to gain experience (peira) of remedies and guarantees their efficacy.

  6. Neuroimaging in alcoholism: ethanol and brain damage.

    PubMed

    Mann, K; Agartz, I; Harper, C; Shoaf, S; Rawlings, R R; Momenan, R; Hommer, D W; Pfefferbaum, A; Sullivan, E V; Anton, R F; Drobes, D J; George, M S; Bares, R; Machulla, H J; Mundle, G; Reimold, M; Heinz, A

    2001-05-01

    This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The co-chairs were Karl Mann and Ingrid Agartz. The presentations were (1) Neuropathological changes in alcohol-related brain damage, by Clive Harper; (2) Regional brain volumes including the hippocampus and monoamine metabolites in alcohol dependence, by Ingrid Agartz, Susan Shoaf, Robert R, Rawlings, Reza Momenan, and Daniel W Hommer; (3) Diffusion tensor abnormalities in imaging of white matter alcoholism, by Adolf Pfefferbaum and Edith V. Sullivan; (4) Use of functional MRI to evaluate brain activity during alcohol cue exposure in alcoholics: Relationship to craving, by Raymond F. Anton, David J. Drobes, and Mark S. George; and (5) mu-Opiate receptor availability in alcoholism: First results from a positron emission tomography study, by Karl Mann, Roland Bares, Hans-Juergen Machulla, Goetz Mundle, Matthias Reimold, and Andreas Heinz.

  7. [Adélaïde Hautval (1906-1988): An exemplary medical personality].

    PubMed

    Halioua, Bruno; Hauptmann, Georges

    2015-12-01

    Adélaïde Hautval (1906-1988), psychiatrist, was arrested in April 1942 having defended a Jewish family abused by German soldiers. She was imprisoned in Bourges and in several camps in France (Pithiviers, Beaune-la-Rolande, Orléans, Romainville) before being deported as a "Friend of the Jews" at Auschwitz in the convoy of 23 January 1943, said 31,000 convoy with 229 other resistant women, Marie-Claude Vaillant-Couturier, Charlotte Delbo, Danielle Casanova. She refused to participate in the "medical" experience of Nazi doctors Clauberg, Schumann, Wirths and Mengele at Birkenau. She was then deported to Ravensbrück. During her deportation, she illustrated her dedication in the medical management of the deportees. She testified repeatedly on her experience of remote doctor. Hautval Adélaïde was the first French woman doctor named Righteous among the Nations in 1965. PMID:26411305

  8. INDIAN CASTE SYSTEM: HISTORICAL AND PSYCHOANALYTIC VIEWS.

    PubMed

    Vallabhaneni, Madhusudana Rao

    2015-12-01

    This paper elucidates the historical origins and transformations of India's caste system. Surveying the complex developments over many centuries, it points out that three positions have been taken in this regard. One suggests that the caste one is born into can be transcended within one's lifetime by performing good deeds. The other declares caste to be immutable forever. And, the third says that one can be reborn into a higher caste if one lives a virtuous life. Moving on to the sociopolitical realm, the paper notes how these positions have been used and exploited. The paper then attempts to anchor the existence and purpose of the Hindu caste system in Freud's ideas about group psychology and Klein's proposals of splitting and projective identification. The paper also deploys the large group psychology concepts of Volkan and the culturally nuanced psychoanalytic anthropology of Roland and Kakar. It concludes with delineating some ameliorative strategies for this tragic problem in the otherwise robust democratic society of India.

  9. Hydrodynamic simulations of microjetting from shock-loaded grooves

    NASA Astrophysics Data System (ADS)

    Roland, Caroline; de Resseguier, Thibaut; Sollier, Arnaud; Lescoute, Emilien; Soulard, Laurent; Loison, Didier

    2015-06-01

    The interaction of a shock wave with a free surface presenting geometrical defects, such as cavities or grooves, may lead to the ejection of micrometric debris at velocities of km/s order. This process can be involved in many applications, like pyrotechnics or industrial safety. Laser shock experiments reported in this conference (T. de Resseguier, C. Roland et al., abstract ref.000066) provide insight into jet formation and peak velocities for various groove angles and shock pressures. Here, we present hydrodynamic simulations of these experiments, in both 2D and 3D geometries, using both finite element method and smoothed particles hydrodynamics. Numerical results are compared to several theoretical predictions including the Richtmyer-Meshkov instabilities. The role of the elastic-plastic behavior on jet formation is investigated. Finally, the possibility to simulate the late stages of jet expansion and fragmentation is explored, to evaluate the mass distribution of the ejecta and their ballistic properties, still essentially unknown in the experiments.

  10. Cognitive Expertise: An ALE Meta-Analysis.

    PubMed

    Neumann, Nicola; Lotze, Martin; Eickhoff, Simon B

    2016-01-01

    Expert performance constitutes the endpoint of skill acquisition and is accompanied by widespread neuroplastic changes. To reveal common mechanisms of reorganization associated with long-term expertise in a cognitive domain (mental calculation, chess, language, memory, music without motor involvement), we used activation likelihood estimation meta-analysis and compared brain activation of experts to nonexperts. Twenty-six studies matched inclusion criteria, most of which reported an increase and not a decrease of activation foci in experts. Increased activation occurred in the left rolandic operculum (OP 4) and left primary auditory cortex and in bilateral premotor cortex in studies that used auditory stimulation. In studies with visual stimulation, experts showed enhanced activation in the right inferior parietal cortex (area PGp) and the right lingual gyrus. Experts' brain activation patterns seem to be characterized by enhanced or additional activity in domain-specific primary, association, and motor structures, confirming that learning is localized and very specialized. PMID:26467981

  11. [Adélaïde Hautval (1906-1988): An exemplary medical personality].

    PubMed

    Halioua, Bruno; Hauptmann, Georges

    2015-12-01

    Adélaïde Hautval (1906-1988), psychiatrist, was arrested in April 1942 having defended a Jewish family abused by German soldiers. She was imprisoned in Bourges and in several camps in France (Pithiviers, Beaune-la-Rolande, Orléans, Romainville) before being deported as a "Friend of the Jews" at Auschwitz in the convoy of 23 January 1943, said 31,000 convoy with 229 other resistant women, Marie-Claude Vaillant-Couturier, Charlotte Delbo, Danielle Casanova. She refused to participate in the "medical" experience of Nazi doctors Clauberg, Schumann, Wirths and Mengele at Birkenau. She was then deported to Ravensbrück. During her deportation, she illustrated her dedication in the medical management of the deportees. She testified repeatedly on her experience of remote doctor. Hautval Adélaïde was the first French woman doctor named Righteous among the Nations in 1965.

  12. Stereochemical investigation of cometary matter onboard the Rosetta Lander.

    PubMed

    Meierhenrich, U J; Thiemann, W H; Rosenbauer, H

    2001-01-01

    At present the European Space Agency is working on one of its Cornerstone Missions, named "Rosetta", to be launched in January 2003 for a visit to comet 46P/Wirtanen2 in 2011. The Rosetta spacecraft will carry a small subsatellite, the Rosetta Lander3 (RoLand), to be detached from the orbiter and land on the surface of the comet's nucleus. One of our main scientific interests is to find out whether chiral organic compounds in cometary matter brought to the Earth by cometary impacts might have had, due to corresponding enantiomeric excesses, a seed function in determining the handedness which is characteristic of homochiral compounds employed by life on Earth. For this reason we have developed an Experiment for the ROSETTA mission, named Cometary Sampling and Composition Experiment (COSAC).

  13. Seventeenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W.

    1992-01-31

    PREFACE The Seventeenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 29-31, 1992. There were one hundred sixteen registered participants which equaled the attendance last year. Participants were from seven foreign countries: Italy, Japan, United Kingdom, France, Belgium, Mexico and New Zealand. Performance of many geothermal fields outside the United States was described in the papers. The Workshop Banquet Speaker was Dr. Raffaele Cataldi. Dr. Cataldi gave a talk on the highlights of his geothermal career. The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy was awarded to Dr. Cataldi. Dr. Frank Miller presented the award at the banquet. Thirty-eight papers were presented at the Workshop with two papers submitted for publication only. Dr. Roland Horne opened the meeting and the key note speaker was J.E. ''Ted'' Mock who discussed the DOE Geothermal R. & D. Program. The talk focused on aiding long-term, cost effective private resource development. Technical papers were organized in twelve sessions concerning: geochemistry, hot dry rock, injection, geysers, modeling, and reservoir mechanics. Session chairmen were major contributors to the program and we thank: Sabodh Garg., Jim Lovekin, Jim Combs, Ben Barker, Marcel Lippmann, Glenn Horton, Steve Enedy, and John Counsil. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual equipment and to Francois Groff who coordinated the meeting arrangements for the Workshop. Henry J. Ramey, Jr. Roland N. Horne Frank G. Miller Paul Kruger William E. Brigham Jean W. Cook -vii

  14. The 27-item Coping Strategies Questionnaire – Revised: Confirmatory factor analysis, reliability and validity in Italian-speaking subjects with chronic pain

    PubMed Central

    Monticone, Marco; Ferrante, Simona; Giorgi, Ines; Galandra, Caterina; Rocca, Barbara; Foti, Calogero

    2014-01-01

    BACKGROUND: Increasing attention is being devoted to cognitive-behavioural measures to improve interventions for chronic pain. OBJECTIVE: To develop an Italian version of the Coping Strategies Questionnaire – Revised (CSQ-R), and to validate it in a study involving 345 Italian subjects with chronic pain. METHODS: The questionnaire was developed following international recommendations. The psychometric analyses included confirmatory factor analysis; reliability, assessed by internal consistency (Cronbach’s alpha) and test-retest reliability (intraclass correlation coefficients); and construct validity, assessed by calculating the correlations between the subscales of the CSQ-R and measures of pain (numerical rating scale), disability (Sickness Impact Profile – Roland Scale), depression (Center for Epidemiological Studies – Depression Scale) and coping (Chronic Pain Coping Inventory) (Pearson’s correlation). RESULTS: Confirmatory factor analysis revealed that the CSQ-R model had an acceptable data-model fit (comparative fit index and normed fit index ≤0.90, root mean square error of approximation ≥0.08). Cronbach’s alpha was satisfactory (CSQ-R 0.914 to 0.961), and the intraclass correlation coefficients were good/excellent (CSQ-R 0.850 to 0.918). As expected, the correlations with the numerical rating scale, Sickness Impact Profile – Roland Scale, Center for Epidemiological Studies – Depression Scale and Chronic Pain Coping Inventory highlighted the adaptive and maladaptive properties of most of the CSQ-R subscales. CONCLUSION: The CSQ-R was successfully translated into Italian. The translation proved to have good factorial structure, and its psychometric properties are similar to those of the original and other adapted versions. Its use is recommended for clinical and research purposes in Italy and abroad. PMID:24761430

  15. Alpha power and coherence primarily reflect neural activity related to stages of motor response during a continuous monitoring task.

    PubMed

    Moore, Roger A; Gale, Anthony; Morris, Paul H; Forrester, Dave

    2008-08-01

    Previously, EEG theta (4-6 Hz) was related to goal conflict resolution [Moore, R.A., Gale, A., Morris, P.H., Forrester, D., 2006. Theta phase locking across the neocortex reflects cortico-hippocampal recursive communication during goal conflict resolution. Int. J. Psychophysiol. 60, 260-273] in the context of theory linked with animal hippocampal theta [Gray, J.A., McNaughton, N., 2000. The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal system, 2nd ed, Oxford University Press, Oxford]. Here, the hypothesis that human EEG alpha (8-12 Hz) may also be a natural analogue to animal hippocampal theta is tested. Participants engaged in a monitoring task where the object was to press a response key immediately after presentation of 4 individual, non-repeating, single integer odd digits. These were presented amongst a continuous stream of single integer digits and Xs. EEG recorded in the earlier study were reanalysed; this time extracting alpha power and coherence from the same 34 participants. Alpha had a different profile to theta and was not primarily related to goal conflict. Low alpha (8-10 Hz) coherence consistently increased at electrodes close to primary sensorimotor cortex; particularly during response execution and response inhibition. The coherence analysis revealed that high alpha (10-12 Hz) related to response execution. Supplementary analyses demonstrated widespread high alpha coherence increase during response execution, inhibition and preparation. These data were discussed within the context of motor driven 'classic alpha' and Rolandic mu. A coherence profile which differentiated response execution and response inhibition was proposed to reflect a working memory network which was activated during response execution. Also, alpha power (8-12 Hz) reduced at several central electrodes during response execution. This reflected classic Rolandic mu response. Participants displaying a predicted low alpha power trend had the

  16. Probing of structural relaxation times in the glassy state of sucrose and trehalose based on dynamical properties of two secondary relaxation processes

    NASA Astrophysics Data System (ADS)

    Kaminski, K.; Adrjanowicz, K.; Kaminska, E.; Paluch, M.

    2011-06-01

    Time-dependent isothermal dielectric measurements were carried out deeply in the glassy state on two very important saccharides: sucrose and trehalose. In both compounds two prominent secondary relaxation processes were identified. The faster one is an inherent feature of the whole family of carbohydrates. The slower one can also be detected in oligo- and polysaccharides. It was shown earlier that the β process is the Johari-Goldstein (JG) relaxation coupled to motions of the glycosidic linkage, while the γ relaxation originates from motions of the exocyclic hydroxymethyl unit. Recently, it was shown that the JG relaxation process can be used to determine structural relaxation times in the glassy state [R. Casalini and C. M. Roland, Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.102.035701 102, 035701 (2009)]. In this paper we present the results of an analysis of the data obtained during aging using two independent approaches. The first was proposed by Casalini and Roland, and the second one is based on the variation of the dielectric strength of the secondary relaxation process during aging [J. K. Vij and G. Power, J. Non-Cryst. SolidsJNCSBJ0022-309310.1016/j.jnoncrysol.2010.07.067 357, 783 (2011)]. Surprisingly, we found that the estimated structural relaxation times in the glassy state of both saccharides are almost the same, independent of the type of secondary mode. This finding calls into question the common view that secondary modes of intramolecular origin do not provide information about the dynamics of the glassy state.

  17. Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex.

    PubMed

    Roll, Patrice; Vernes, Sonja C; Bruneau, Nadine; Cillario, Jennifer; Ponsole-Lenfant, Magali; Massacrier, Annick; Rudolf, Gabrielle; Khalife, Manal; Hirsch, Edouard; Fisher, Simon E; Szepetowski, Pierre

    2010-12-15

    It is a challenge to identify the molecular networks contributing to the neural basis of human speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech (developmental verbal dyspraxia, DVD), whereas mutations of sushi-repeat protein SRPX2 lead to epilepsy of the rolandic (sylvian) speech areas, with DVD or with bilateral perisylvian polymicrogyria. Pathophysiological mechanisms driven by SRPX2 involve modified interaction with the plasminogen activator receptor (uPAR). Independent chromatin-immunoprecipitation microarray screening has identified the uPAR gene promoter as a potential target site bound by FOXP2. Here, we directly tested for the existence of a transcriptional regulatory network between human FOXP2 and the SRPX2/uPAR complex. In silico searches followed by gel retardation assays identified specific efficient FOXP2-binding sites in each of the promoter regions of SRPX2 and uPAR. In FOXP2-transfected cells, significant decreases were observed in the amounts of both SRPX2 (43.6%) and uPAR (38.6%) native transcripts. Luciferase reporter assays demonstrated that FOXP2 expression yielded a marked inhibition of SRPX2 (80.2%) and uPAR (77.5%) promoter activity. A mutant FOXP2 that causes DVD (p.R553H) failed to bind to SRPX2 and uPAR target sites and showed impaired down-regulation of SRPX2 and uPAR promoter activity. In a patient with polymicrogyria of the left rolandic operculum, a novel FOXP2 mutation (p.M406T) was found in the leucine-zipper (dimerization) domain. p.M406T partially impaired the FOXP2 regulation of SRPX2 promoter activity, whereas that of the uPAR promoter remained unchanged. Together with recently described FOXP2-CNTNAP2 and SRPX2/uPAR links, the FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders.

  18. Patient Expectations as Predictors of Outcome In Patients with Acute Low Back Pain

    PubMed Central

    Phillips, Russell S.; Davis, Roger B.; Cherkin, Daniel C.; Legedza, Anna; Kaptchuk, Ted J.; Hrbek, Andrea; Buring, Julie E.; Post, Diana; Connelly, Maureen T.; Eisenberg, David M.

    2007-01-01

    BACKGROUND Few studies have evaluated the association between patient expectations for recovery and clinical outcomes, and no study has evaluated whether asking patients to choose their therapy modifies such an association. OBJECTIVE To evaluate the association between patients’ expectations and functional recovery in patients with acute low back pain (LBP), and to determine whether that association is affected by giving patients choice of therapy. DESIGN AND PARTICIPANTS A secondary analysis of a randomized controlled trial comparing usual care alone to usual care plus choice of chiropractic, acupuncture, or massage in 444 adults with acute LBP, lasting less than 21 days. MEASUREMENTS AND MAIN RESULTS Primary outcome was functional disability (Roland score) at 5 and 12 weeks. Patients’ general expectations for improvement were associated with improvement in functional status (β = 0.96, 95% CI = 0.56, 1.36). A 1-point increase in general expectations was associated with a 0.96-point improvement in Roland score. The association of expectation with outcome was 2–3 times greater in the usual care group than the choice group. However, these differences did not reach statistical significance. CONCLUSIONS In patients with acute LBP, higher expectations for recovery are associated with greater functional improvement. Eliciting patient expectations for improvement may be a simple way to identify patients with the highest (or lowest) likelihood of experiencing functional improvement. Incorporating questions about patient expectations in future trials may clarify the role of this important correlate of clinical outcomes. PMID:18066631

  19. A double-blind controlled trial of a single dose naproxen and an amino acid medical food theramine for the treatment of low back pain.

    PubMed

    Shell, William E; Charuvastra, Elizabeth H; DeWood, Marcus A; May, Lawrence A; Bullias, Debora H; Silver, David S

    2012-03-01

    To study the safety and efficacy of a new medical food (Theramine) in the treatment of low back pain, we performed a 28-day double-blind randomized controlled trial in 129 patients. Back pain was present for at least 6 weeks and was not mild. Patients were randomly assigned to receive medical food alone (n = 43), naproxen alone (250 mg/d, n = 42), or both medical food and naproxen (n = 44). All patients were assessed by using Roland-Morris Disability Questionnaire, Oswestry Low Back Pain Scale, Visual Analog Scale Evaluation and laboratory analysis performed at baseline and at 28 days for assessing the safety and impact on inflammatory markers, which included complete blood counts, C-Reactive protein (CRP), and liver function (alkaline phosphatase, aspartate transaminase, and alanine transaminase). At baseline, there were no statistically significant differences in low back pain when assessed by Roland-Morris function or Oswestry assessments nor were there differences in the blood indices of inflammation. At day 28, both the medical food group and combined therapy group (medical food with naproxen) were statistically significantly superior to the naproxen-alone group (P < 0.05). The medical food and naproxen group showed functional improvement when compared to the naproxen-alone group. The naproxen-alone group showed significant elevations in CRP, alanine transaminase, and aspartate transaminase when compared with the other groups. Medical food alone or with naproxen showed no significant change in liver function tests or CRP, with medical food potentially mitigating the effects seen with naproxen alone. The medical food (Theramine) appeared to be effective in relieving back pain without causing any significant side effects and may provide a safe alternative to presently available therapies.

  20. Interaction of gustatory and lingual somatosensory perceptions at the cortical level in the human: a functional magnetic resonance imaging study.

    PubMed

    Cerf-Ducastel, B; Van de Moortele, P F; MacLeod, P; Le Bihan, D; Faurion, A

    2001-05-01

    The present study has investigated interaction at the cortical level in the human between two major components of flavor perception, pure chemical gustatory and lingual somatosensory perception. Twelve subjects participated in a functional magnetic resonance imaging study and tasted six stimuli, applied on the whole tongue, among which four were pure gustatory stimuli (NaCl, aspartame, quinine and HCl, pH 2.4 or 2.2) and two were both taste and lingual somatosensory stimuli, i.e. somato-gustatory stimuli (HCl, pH 1.6 or 1.5, and aluminum potassium sulfate). Functional images were acquired with an echo planar sequence on a 3 T system and were individually processed by correlation with the temporal perception profile. Both sets of stimuli showed activation in the same cortical areas, namely the insula, the rolandic operculum (base of the pre- and post-central gyri), the frontal operculum and the temporal operculum, confirming a wide overlap of taste and lingual somatosensory representations. However, the relative activation across areas and the analysis of co-activated areas across all runs for each set of stimuli allowed discrimination of taste and somatosensory modalities. Factor analysis of correspondences indicated different patterns of activation across the sub-insular and opercular regions, depending on the gustatory or somato-gustatory nature of the stimuli. For gustatory stimuli different activation patterns for the superior and inferior parts of the insula suggested a difference in function between these two insular sub-regions. Furthermore, the left inferior insula was co-activated with the left angular gyrus, a structure involved in semantic processing. In contrast, only somato-gustatory stimuli specifically produced a simultaneous and symmetrical activation of both the left and right rolandic opercula, which include a part of the sensory homunculus dedicated to the tactile representation of oral structures.

  1. The effect of violin playing on the bony facial structures in adolescents.

    PubMed

    Kovero, O; Könönen, M; Pirinen, S

    1997-08-01

    Holding a violin between shoulder and chin needs a special kind of muscle function. The purpose of this investigation was to determine whether this kind of muscular activity is a modifying factor for facial growth in adolescence. The bony facial dimensions of 24 adolescent violin students attending colleges of music with a playing history of 5-11 years were measured from lateral and posteroanterior cephalograms and panoramic tomograms of the jaws. The dimensions were compared with those of sex- and age-matched controls. Significant differences were found between violin players and controls. The players had higher faces, especially on the right side of the lower face and in the right mandibular ramus. The players also had more proclined upper and lower incisors than the controls. It is concluded that the overall greater facial height in violinists reflects the increased face muscle activity and the higher bony dimensions of the right side of the face are due to the muscular activity produced on that side to balance the load caused by the violin on the left. The greater proclination of the incisors is the result of an altered balance of muscular activity between tongue and lip, and the pressure of the violin to the chin. PMID:9308257

  2. Honest sexual signaling in turtles: experimental evidence of a trade-off between immune response and coloration in red-eared sliders Trachemys scripta elegans

    NASA Astrophysics Data System (ADS)

    Ibáñez, Alejandro; Polo-Cavia, Nuria; López, Pilar; Martín, José

    2014-10-01

    Sexual signals can be evolutionarily stable if they are honest and condition dependent or costly to the signaler. One possible cost is the existence of a trade-off between maintaining the immune system and the elaboration of ornaments. This hypothesis has been experimentally tested in some groups of animals but not in others such as turtles. We experimentally challenged the immune system of female red-eared sliders Trachemys scripta elegans, with a bacterial antigen (lipopolysaccharide (LPS)) without pathogenic effects to explore whether the immune activation affected visual colorful ornaments of the head. The LPS injection altered the reflectance patterns of color ornaments. In comparison to the control animals, the yellow chin stripes of injected animals exhibited (1) reduced brightness, (2) lower long wavelength (>470 nm) reflectance, and (3) lower values for carotenoid chroma. The postorbital patches of injected individuals also showed reduced very long wavelength (>570 nm) reflectance but did not change in carotenoid chroma. Thus, experimental turtles showed darker and less "yellowish" chin stripes and less "reddish" postorbital patches at the end of the experiment, whereas control turtles did not change their coloration. This is the first experimental evidence supporting the existence of a trade-off between the immune system and the expression of visual ornaments in turtles. We suggest that this trade-off may allow turtles to honestly signal individual quality via characteristics of coloration, which may have an important role in intersexual selection processes.

  3. Taiwanese Political Parties can be Categorized by Face, by Those Who Reported Making Face-To-Trait Inferences

    PubMed Central

    Hu, Shun-Fu; Chang, Chien-Kai; Chen, Yu-Chen; Chien, Sarina Hui-Lin

    2016-01-01

    The present study aims to replicate and extend Rule and Ambady (2010a)'s findings that Republicans and Democrats could be differentiated by face. In Experiment 1, undergraduates categorized 50 gray-scale full-face photos of candidates of the two major political parties in Taiwan, the Kuomingtang (KMT) and the Democratic Progressive Party (DPP). Using identical stimuli and procedure, Experiment 2 tested 25- to 57-year-olds. Experiment 3 tested undergraduates with cropped photos, Experiment 4, with photos devoid of the mouth and chin area. At the end of each Experiment, we interviewed the participants about the strategies used. Results showed that undergraduates could categorize KMT and DPP with accuracies significantly higher than chance in full-face photos (Experiment 1), M = 0.524, p = 0.045, cropped photos (Experiment 3), M = 0.534, p = 0.016, and photos devoid of the mouth-and-chin area (Experiment 4), M = 0.530, p = 0.048. Adults aged between 25 and 57 could also categorize full-face photos (Experiment 2), M = 0.557, p < 0.001. Analysis on strategy use revealed that the better-than-chance performance may be a unique contribution of those who reported making face-to-trait inferences. In sum, we replicated Rule and Ambady's (2010a) results in East Asian and found that face-to-trait inferences may be essential. PMID:26793130

  4. Long-term under-masculinization in male rabbits due to maternal stress is reversed by prenatal administration of testosterone.

    PubMed

    Bánszegi, Oxána; Szenczi, Péter; Dúcs, Anita; Hudson, Robyn; Altbäcker, Vilmos

    2015-06-01

    It is well established that in mammals prenatal exposure to exogenous testosterone has a masculinizing effect on female morphology and behavior. Fewer studies, however, have been conducted in males on this subject, and the results are controversial. In the present study, we investigated the long-term effect of administering extra prenatal testosterone (testosterone proprionate; TP) on adult male domestic rabbits' morphology and behavior using two different control groups, non-treated and vehicle injected mothers. Unexpectedly, administering the vehicle alone had a clear under-masculinizing effect on all morphological and behavioral measures; lower body mass, smaller anogenital distance and smaller chin glands, lower chin-marking activity and greater timidity. Administration of TP counteracted this effect in a dose-dependent manner such that animals exposed to the highest dose prenatally showed values on the morphological and behavioral measures equivalent to but not greater than the non-treated control group. We conclude (1) that additional testosterone beyond what male fetuses produce in utero does not result in increased masculinization, and thus, that male fetuses are less susceptible prenatally to hormonal effects than females, and (2) that presumably stress-related effects of administering the vehicle alone resulted in under-masculinization, which could be recovered by the prenatal administration of TP. These results may partly account for the contradictory findings of previous studies, and indicate the importance of including both non-treated and sham- (vehicle) treated controls in future experiments.

  5. Effects of facial hard tissue surgery on facial aesthetics: changes in facial content and frames.

    PubMed

    Choi, Jin-Young; Lee, Sang-Hoon; Baek, Seung-Hak

    2012-11-01

    Aesthetic units of the face can be divided into facial content (FC; eyes, nose, lips, and mouth), anterior facial frame (AFF; a contour line from the trichion, the temporal line of the frontal bone, the lateral orbital rim, the most lateral line of the anterior part of the zygomatic body, the anterior border of the masseter muscle, to the inferior border of the chin), and posterior facial frame (PFF; a contour line from the hairline, the zygomatic arch, to the ramus and gonial angle area of the mandible). The size and shape of each FC and the balance and proportion between FCs create a unique appearance for each person. The facial form can be determined through the combination of AFF and PFF. In the Asian population, clinicians frequently encounter problems of FC (eg, acute nasolabial angle, protrusive and everted lips, nonconsonant lip line, or lip canting), AFF (eg, midface hypoplasia, protrusive and asymmetric chin, vertical deficiency/excess of the anterior maxilla and symphysis, or prominent zygoma), and PFF (eg, square mandibular angle). These problems can be efficiently and effectively corrected through the combination of hard tissue surgery such as anterior segmental osteotomy, genioplasty, mandibular angle reduction, malarplasty, and orthognathic surgery. Therefore, the purposes of this article were to introduce the concepts of FC, AFF, and PFF, and to explain the effects of facial hard tissue surgery on facial aesthetics.

  6. Comparison of the reproducibility of panoramic radiographs between dentulous and edentulous patients

    PubMed Central

    Park, Jong-Woong; Huh, Kyung-Hoe; Yi, Won-Jin; Lee, Sam-Sun; Choi, Soon-Chul

    2014-01-01

    Purpose This study was performed to evaluate the reproducibility of panoramic radiographs of dentulous and edentulous patients. Materials and Methods The reproducibility of panoramic radiographs was evaluated using the panoramic radiographs acquired from 30 anterior dentulous patients by using a common biting positioning device (dentulous group) and 30 anterior edentulous patients by using chin-support devices to take a panoramic radiograph (edentulous group), respectively; these patients had undergone 3 or more panoramic radiographs. The widths and angles between the designated landmarks were measured on the panoramic radiographs, and the reproducibility was evaluated using the intraclass correlation coefficient (ICC) and the coefficient of variation. Results In the dentulous and edentulous groups, the ICCs of the mandibular ramus and mandibular angle areas were higher than the condylar head and zygomatic areas. The mandibular ramus and angle areas showed statistically lower mean coefficients of variation than the condylar head and zygomatic areas in the dentulous group. The mandibular angle area showed a significantly lower mean coefficient of variation than the zygomatic area in the edentulous group. By comparing the two groups, each ICC of the edentulous group was lower than that of the dentulous group, and the mean coefficients of variation of the mandibular ramus area, zygomatic area, left condylar inclination, and ramus ratio between the right and the left in the edentulous group were significantly higher than those in the dentulous group. Conclusion Biting positioning for dentulous patients provided better positioning reproducibility than chin-support positioning when performing panoramic radiography for edentulous patients. PMID:24944958

  7. Comment on ``Adiabatic quantum computation with a one-dimensional projector Hamiltonian''

    NASA Astrophysics Data System (ADS)

    Kay, Alastair

    2013-10-01

    The partial adiabatic search algorithm was introduced in Tulsi's paper [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.80.052328 80, 052328 (2009)] as a modification of the usual adiabatic algorithm for a quantum search with the idea that most of the interesting computation only happens over a very short range of the adiabatic path. By focusing on that restricted range, one can potentially gain an advantage by reducing the control requirements on the system, enabling a uniform rate of evolution. In this Comment, we point out an oversight in Tulsi's paper [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.80.052328 80, 052328 (2009)] that invalidates its proof. However, the argument can be corrected, and the calculations in Tulsi's paper [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.80.052328 80, 052328 (2009)] are then sufficient to show that the scheme still works. Nevertheless, subsequent works [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.82.034304 82, 034304 (2010), Chin. Phys. BCPBHAJ1674-105610.1088/1674-1056/20/4/040309 20, 040309 (2011), Chin. Phys. BCPBHAJ1674-105610.1088/1674-1056/21/1/010306 21, 010306 (2012), AASRI Procedia 1, 5862 (2012), and Quantum Inf. Process.10.1007/s11128-013-0557-1 12, 2689 (2013)] cannot all be recovered in the same way.

  8. Jade and gold originally as drugs in China.

    PubMed

    Mahdihassan, S

    1981-01-01

    Demand for a drug identifies its user and also his needs. An aged ascetic living alone in a forest needed a drug to acquire physical strength. His search was guided by the theory that like makes like. Accordingly, jade was selected as a hard stone that never tarnishes which, when taken as a powder, will make the consumer strong-bodied. Previously, red-ochre was consumed orally on the principle that its redness would increase blood and promote longevity. Jade came to supercede red-ochre or red-earth. Its inscribed character in Chinese, Yü, is a horizontal stroke on the top of Thu, earth or clay. Thus Yü, jade, signifies Super-Earth or a drug superior to red-ochre. Searching for a more potent drug, gold was discovered and, being fireproof, was thus everlasting. Chin, gold, as a character, is composed of Yü, jade, plus a phonetic as the specifying additive. Hence the resultant character, Chin, presents gold as Super-Jade. Briefly, jade is Super (Red)-Earth and gold is Super-Jade.

  9. Modelling of facial growth in Czech children based on longitudinal data: Age progression from 12 to 15 years using 3D surface models.

    PubMed

    Koudelová, Jana; Dupej, Ján; Brůžek, Jaroslav; Sedlak, Petr; Velemínská, Jana

    2015-03-01

    Dealing with the increasing number of long-term missing children and juveniles requires more precise and objective age progression techniques for the prediction of their current appearance. Our contribution includes detailed and real facial growth information used for modelling age progression during adolescence. This study was based on an evaluation of the overall 180 three-dimensional (3D) facial scans of Czech children (23 boys, 22 girls), which were longitudinally studied from 12 to 15 years of age and thus revealed the real growth-related changes. The boys underwent more marked changes compared with the girls, especially in the regions of the eyebrow ridges, nose and chin. Using modern geometric morphometric methods, together with their applications, we modelled the ageing and allometric trajectories for both sexes and simulated the age-progressed effects on facial scans. The facial parts that are important for facial recognition (eyes, nose, mouth and chin) all deviated less than 0.75mm, whereas the areas with the largest deviations were situated on the marginal parts of the face. The mean error between the predicted and real facial morphology obtained by modelling the children from 12 to 15 years of age was 1.92mm in girls and 1.86mm in boys. This study is beneficial for forensic artists as it reduces the subjectivity of age progression methods.

  10. Possible Interbreeding in Late Italian Neanderthals? New Data from the Mezzena Jaw (Monti Lessini, Verona, Italy)

    PubMed Central

    Condemi, Silvana; Mounier, Aurélien; Giunti, Paolo; Lari, Martina; Caramelli, David; Longo, Laura

    2013-01-01

    In this article we examine the mandible of Riparo Mezzena a Middle Paleolithic rockshelter in the Monti Lessini (NE Italy, Verona) found in 1957 in association with Charentian Mousterian lithic assemblages. Mitochondrial DNA analysis performed on this jaw and on other cranial fragments found at the same stratigraphic level has led to the identification of the only genetically typed Neanderthal of the Italian peninsula and has confirmed through direct dating that it belongs to a late Neanderthal. Our aim here is to re-evaluate the taxonomic affinities of the Mezzena mandible in a wide comparative framework using both comparative morphology and geometric morphometrics. The comparative sample includes mid-Pleistocene fossils, Neanderthals and anatomically modern humans. This study of the Mezzena jaw shows that the chin region is similar to that of other late Neanderthals which display a much more modern morphology with an incipient mental trigone (e.g. Spy 1, La Ferrassie, Saint-Césaire). In our view, this change in morphology among late Neanderthals supports the hypothesis of anatomical change of late Neanderthals and the hypothesis of a certain degree of interbreeding with AMHs that, as the dating shows, was already present in the European territory. Our observations on the chin of the Mezzena mandible lead us to support a non abrupt phylogenetic transition for this period in Europe. PMID:23544098

  11. The effect of violin playing on the bony facial structures in adolescents.

    PubMed

    Kovero, O; Könönen, M; Pirinen, S

    1997-08-01

    Holding a violin between shoulder and chin needs a special kind of muscle function. The purpose of this investigation was to determine whether this kind of muscular activity is a modifying factor for facial growth in adolescence. The bony facial dimensions of 24 adolescent violin students attending colleges of music with a playing history of 5-11 years were measured from lateral and posteroanterior cephalograms and panoramic tomograms of the jaws. The dimensions were compared with those of sex- and age-matched controls. Significant differences were found between violin players and controls. The players had higher faces, especially on the right side of the lower face and in the right mandibular ramus. The players also had more proclined upper and lower incisors than the controls. It is concluded that the overall greater facial height in violinists reflects the increased face muscle activity and the higher bony dimensions of the right side of the face are due to the muscular activity produced on that side to balance the load caused by the violin on the left. The greater proclination of the incisors is the result of an altered balance of muscular activity between tongue and lip, and the pressure of the violin to the chin.

  12. Congenital muscular torticollis in adult patients: literature review and a case report using a harmonic scalpel.

    PubMed

    Pombo Castro, María; Luaces Rey, Ramón; Vázquez Mahía, Inés; López-Cedrún Cembranos, José Luís

    2014-02-01

    Congenital torticollis is characterized by shortening and fibrosis of the sternocleidomastoid (SCM) muscle detected at birth or shortly after birth. This leads to a lateral inclination of the head to the ipsilateral shoulder and chin deviation to the opposite side. When diagnosed early, most cases can be conservatively managed with excellent results. In neglected adult cases, the treatment of this entity is more controversial. A review of the different treatment options in neglected adult cases of congenital torticollis is presented, and a case successfully treated by SCM bipolar release is reported. A 35-year-old woman diagnosed with congenital torticollis was referred to the authors' department. She had been diagnosed at 32 years of age and had been conservatively treated, with no success. Physical examination showed a posterior region of the left SCM muscle hard to palpation, with head tilt to the same side and chin deviation to the right. Bipolar release of the SCM muscle was performed under general anesthesia using the harmonic scalpel. Immobilization with a brace was applied during the first 2 weeks and manual stretching was performed after removal of the brace. Head tilt and movement limitation were resolved, achieving good functional and cosmetic results. Although the best treatment results in congenital torticollis are achieved during the first years of childhood, bipolar release of the SCM muscle followed by postsurgical physical therapy can be effective in neglected adult cases.

  13. Honest sexual signaling in turtles: experimental evidence of a trade-off between immune response and coloration in red-eared sliders Trachemys scripta elegans.

    PubMed

    Ibáñez, Alejandro; Polo-Cavia, Nuria; López, Pilar; Martín, José

    2014-10-01

    Sexual signals can be evolutionarily stable if they are honest and condition dependent or costly to the signaler. One possible cost is the existence of a trade-off between maintaining the immune system and the elaboration of ornaments. This hypothesis has been experimentally tested in some groups of animals but not in others such as turtles. We experimentally challenged the immune system of female red-eared sliders Trachemys scripta elegans, with a bacterial antigen (lipopolysaccharide (LPS)) without pathogenic effects to explore whether the immune activation affected visual colorful ornaments of the head. The LPS injection altered the reflectance patterns of color ornaments. In comparison to the control animals, the yellow chin stripes of injected animals exhibited (1) reduced brightness, (2) lower long wavelength (>470 nm) reflectance, and (3) lower values for carotenoid chroma. The postorbital patches of injected individuals also showed reduced very long wavelength (>570 nm) reflectance but did not change in carotenoid chroma. Thus, experimental turtles showed darker and less "yellowish" chin stripes and less "reddish" postorbital patches at the end of the experiment, whereas control turtles did not change their coloration. This is the first experimental evidence supporting the existence of a trade-off between the immune system and the expression of visual ornaments in turtles. We suggest that this trade-off may allow turtles to honestly signal individual quality via characteristics of coloration, which may have an important role in intersexual selection processes.

  14. Dietary Exposure of Nigerians to Mutagens and Estrogen-Like Chemicals

    PubMed Central

    Omoruyi, Iyekhoetin Matthew; Ahamioje, Derek; Pohjanvirta, Raimo

    2014-01-01

    Food and drinking water are poorly delineated sources of human exposure to chemical food mutagens and endocrine-disrupting chemicals. In this study, we investigated the presence of mutagens and chemicals exhibiting estrogenic activity in the daily diet of Nigerians, using in vitro assays. Commercially processed foods or snacks and various brands of pure water sachets were extracted by solid-phase extraction and liquid-liquid extraction, respectively. Mutagenicity was determined by the conventional Ames test and two complementary assays on two strains of Salmonella (TA 100 and TA 98), while the estrogenic activity was assessed by a yeast bioluminescent assay, using two recombinant yeast strains (Saccharomyces cerevisiae BMAEREluc/ERα and S. cerevisiae BMA64/luc). A third of the food varieties investigated (chin-chin, hamburger, suya and bean cake) were mutagenic in all three assays, either in the presence or absence of S9 mix. Of the packed water samples, five out of the sixteen investigated (31%), were found to be estrogenic, with estradiol and bisphenol A equivalents ranging from 0.79 to 44.0 ng/L and 124.2 to 1,000.8 ng/L, respectively. Hence, although the current situation in Nigeria does not appear to be substantially worse than, e.g., in Europe, regular monitoring is warranted in the future. PMID:25153465

  15. Physiological characteristics of National Collegiate Athletic Association Division I ice hockey players and their relation to game performance.

    PubMed

    Peyer, Karissa L; Pivarnik, James M; Eisenmann, Joey C; Vorkapich, Michael

    2011-05-01

    Previous ice hockey research has focused on physiological profiles and determinants of skating speed, but few studies have examined the association of preseason player evaluations with a measure of season-long performance. Understanding which tests are most predictive of player performance could help coaches organize practice and training more effectively. The purpose of this study was to describe physical characteristics and skill levels of 24 members of an NCAA Division I men's ice hockey team and relate them to game performance over the course of a season as measured by plus/minus (+/-) score. Subjects performed a battery of preseason tests including treadmill maximal aerobic capacity, body fat, leg press, push-ups, bench press, chin-ups, and sprinting ability both on and off ice. Pearson and Spearman correlations were used to examine correlations between preseason measures and +/- score. One coach also subjectively grouped the top and bottom 6 players, and analysis of variance was used to examine any differences in preseason measures and +/- score between these 2 groups. Leg press, chin-ups, bench press, and repeat sprint performance were significantly correlated with +/- score (r = 0.554, 0.462, 0.499, and -0.568, respectively). Teams with limited time and resources may choose to perform these tests to evaluate player potential efficiently. Only +/- score differed between top and bottom players suggesting that +/- accurately reflected the coach's perception of player success in this sample. PMID:21478763

  16. Aeroacoustic sources of motorcycle helmet noise.

    PubMed

    Kennedy, J; Adetifa, O; Carley, M; Holt, N; Walker, I

    2011-09-01

    The prevalence of noise in the riding of motorcycles has been a source of concern to both riders and researchers in recent times. Detailed flow field information will allow insight into the flow mechanisms responsible for the production of sound within motorcycle helmets. Flow field surveys of this nature are not found in the available literature which has tended to focus on sound pressure levels at ear as these are of interest for noise exposure legislation. A detailed flow survey of a commercial motorcycle helmet has been carried out in combination with surface pressure measurements and at ear acoustics. Three potential noise source regions are investigated, namely, the helmet wake, the surface boundary layer and the cavity under the helmet at the chin bar. Extensive information is provided on the structure of the helmet wake including its frequency content. While the wake and boundary layer flows showed negligible contributions to at-ear sound the cavity region around the chin bar was identified as a key noise source. The contribution of the cavity region was investigated as a function of flow speed and helmet angle both of which are shown to be key factors governing the sound produced by this region. PMID:21895059

  17. Taiwanese Political Parties can be Categorized by Face, by Those Who Reported Making Face-To-Trait Inferences.

    PubMed

    Hu, Shun-Fu; Chang, Chien-Kai; Chen, Yu-Chen; Chien, Sarina Hui-Lin

    2015-01-01

    The present study aims to replicate and extend Rule and Ambady (2010a)'s findings that Republicans and Democrats could be differentiated by face. In Experiment 1, undergraduates categorized 50 gray-scale full-face photos of candidates of the two major political parties in Taiwan, the Kuomingtang (KMT) and the Democratic Progressive Party (DPP). Using identical stimuli and procedure, Experiment 2 tested 25- to 57-year-olds. Experiment 3 tested undergraduates with cropped photos, Experiment 4, with photos devoid of the mouth and chin area. At the end of each Experiment, we interviewed the participants about the strategies used. Results showed that undergraduates could categorize KMT and DPP with accuracies significantly higher than chance in full-face photos (Experiment 1), M = 0.524, p = 0.045, cropped photos (Experiment 3), M = 0.534, p = 0.016, and photos devoid of the mouth-and-chin area (Experiment 4), M = 0.530, p = 0.048. Adults aged between 25 and 57 could also categorize full-face photos (Experiment 2), M = 0.557, p < 0.001. Analysis on strategy use revealed that the better-than-chance performance may be a unique contribution of those who reported making face-to-trait inferences. In sum, we replicated Rule and Ambady's (2010a) results in East Asian and found that face-to-trait inferences may be essential.

  18. [The results of using extraoral traction in children with a prognathic bite].

    PubMed

    Latiĭ, A A

    1990-01-01

    Primary and repeated lateral teleroentgenograms of the head of 37 children aged 4-8 with prognathic occlusion were analyzed, recorded on an average in 2 years after employment of a chin sling with extraoral traction. Analysis has shown normalization of the jaws and occlusion in the sagittal plane, resultant from limitation of mesial transposition of the mandible in the skull in the course of facial skeleton growth. This has been achieved at the expense of inhibition of longitudinal growth of the mandibular body and ascending branches more than twofold as against the reference values and was also a result of mandibular shift due to traction and of enhanced vertical transposition of the mandible in the skull due to distal rotation. The principal indications for the employment of chin sling in the management of prognathic occlusion are intensive growth of the mandible or a tendency to such growth, mesial position of the mandible in the skull, and a combination of these disorders, that may be the principal or additional factors contributing to the pathogenesis of this abnormality.

  19. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation.

    PubMed

    Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Quinto-Sánchez, Mirsha; Mendoza-Revilla, Javier; Camilo Chacón-Duque, Juan; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; Pérez, Gastón Macín; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya, Gabriel; Rothhammer, Francisco; Headon, Denis; González-José, Rolando; Balding, David; Ruiz-Linares, Andrés

    2016-01-01

    We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10(-8)) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of ∼3,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion. PMID:27193062

  20. Introduction to Chinese Medical Literature

    PubMed Central

    Kan, Lai-Bing

    1965-01-01

    The history of medicine in China is divided into four periods, from about 2700 B.C. to the present. Brief descriptions of standard works of these periods (e.g. Pèn-Ts'ao, Nei Ching, Nan Ching, Shang Han Lun, Ch'in K'ue Yao Lüeh, Chai I Ching, Chou Hou Pei Chi Fang, Mo Ching, Ming I Pieh Lu, Ch'ao Shih Pin Yüan, Chien Chin Yao Fang, Wai T'ai Pi Yao, Hsi Yüan Lu, Pèn-Ts'ao Kang-Mu, etc.) are given. The latter part of the paper deals with the state of modern medical research and literature in Mainland China, where equal emphasis is placed on the practice of both traditional Chinese and Western medicine in the treatment of diseases, thus resulting in a new era in Chinese medical history. This is based on the information obtainable in Hong Kong. Information about medical developments in Taiwan is readily available elsewhere and so has been omitted. PMID:14223740

  1. Dislocation of temporo-mandibular joint - an uncommon circumstance of occurrence: vaginal delivery.

    PubMed

    El Bouazzaoui, Abderrahim; Labib, Smael; Derkaoui, Ali; Adnane Berdai, Mohammed; Bendadi, Azzeddine; Harandou, Mustapha

    2010-06-25

    Dislocation of temporo-mandibular joint (TMJ) is an infrequent disease but still spectacular. This disease consists of a permanent, to some extent complete disruption of the temporo-mandibular joint. These dislocations often occur in a context of yawning, and less frequently after a burst of laughing or relatively mild facial trauma (slap, punch on the chin). We report a case of TMJ occurring in an uncommon circumstance: vaginal delivery. A woman aged 24-years with no special past medical history; primipara was admitted in the Department of Maternity of the University Hospital Hassan II of Fez for an imminent delivery of a twin pregnancy. Ten minutes after admission, the patient delivered vaginally with episiotomy. She gave birth to twins weighing 2800 g and 2400 g. During labour, and due to efforts of crying, the patient developed a sudden and immediate loss of function of the temporo-mandibular joint, with difficulty of speaking, the mouth permanently opened and with the chin lowered and thrown forward. The examination found an empty glenoid fossa of the temporo-mandibular joint in both sides. The diagnosis of dislocation of the TMJ was established. A CT scan of facial bones was done, objectifying a bilateral dislocation of TMJ. The reduction of this dislocation was performed in the operating room under sedation.

  2. Donor site morbidity after reconstruction of alveolar bone defects with mandibular symphyseal bone grafts in cleft patients--111 consecutive patients.

    PubMed

    Andersen, K; Nørholt, S E; Knudsen, J; Küseler, A; Jensen, J

    2014-04-01

    The aim of this study was to assess the objective and subjective morbidity after reconstruction of alveolar bone defects with mandibular symphyseal bone grafts in patients with cleft lip and palate. One hundred and eleven patients born between 1995 and 1999, who had undergone chin bone harvesting for alveolar cleft reconstruction in the period from 2000 through 2011, were included. A survey of medical records was conducted. Subjective morbidity after reconstruction was assessed using a questionnaire. Medical records revealed few postoperative incidents; 5.6% reported persistent sensory disturbances in the donor area. Postoperative pain averaged 3.6 ± 2.1 (scale 0-10). The overall satisfaction with the surgical result was 8.7 ± 1.7 (scale 0-10). This study revealed that chin bone harvesting for reconstruction of alveolar defects in patients with cleft lip and palate is a safe and predictable procedure, highly appreciated by the patients, and characterized by only minor postoperative incidents. Patients must be informed of the risk of sensory disturbances in the donor area.

  3. Midline facial soft tissue thickness database of Turkish population: MRI study.

    PubMed

    Sipahioğlu, Serdar; Ulubay, Hakan; Diren, H Barış

    2012-06-10

    Facial reconstruction is the approximation of an antemortem face from human skeletal remains. Since the nineteenth century, several methods have been developed for reconstruction of the face; all of them require the measurement of average tissue thicknesses at various points on the face. To our knowledge, there are no publications on soft tissue thickness in the Turkish population. In addition, there are few publications on the value of magnetic resonance imaging (MRI) in measuring soft tissue thickness for forensic sciences. The aim of this study was to create a reference database of facial tissue thickness in the Turkish population, and to present data illustrating the successful use of MRI for this purpose. The study included 161 patients (79 males and 82 females) between the ages of 18 and 78 who had undergone brain MRI in our radiology clinic, and showed no sign of maxillofacial pathology. Measurements were taken at 9 points at the midline; glabella, nasion, end of nasals, mid-philtrum, upper lip margin, lower lip margin, chin-lip fold, mental eminence, and beneath chin points. The mean values for these points in the patient sample population were determined, and differences related to age, sex, and body mass index (BMI) were calculated. The values were then compared to the findings of the Manhein study.

  4. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

    PubMed Central

    Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Quinto-Sánchez, Mirsha; Mendoza-Revilla, Javier; Camilo Chacón-Duque, Juan; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; Pérez, Gastón Macín; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria- Cátira; Canizales-Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya, Gabriel; Rothhammer, Francisco; Headon, Denis; González-José, Rolando; Balding, David; Ruiz-Linares, Andrés

    2016-01-01

    We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10−8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of ∼3,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion. PMID:27193062

  5. Cervical Spondylotic Myelopathy Secondary to Dropped Head Syndrome: Report of a Case and Review of the Literature

    PubMed Central

    Soufiani, Housain F.; Rahimizadeh, Saghayegh

    2016-01-01

    The dropped head syndrome (DHS) is a disabling condition caused by severe weakness of the neck extensor muscles causing progressive reducible kyphosis of the cervical spine and the inability to hold the head up. Weakness can occur in isolation or in association with a generalized neuromuscular disorder. Isolated cases are owed to the late onset of noninflammatory myopathy designated as INEM, where persistent chin to chest deformity may gradually cause or aggravate preexisting degenerative changes of the cervical spine and ultimately result in myelopathy. In review of the literature, we could find only 5 cases, with no unique guidelines to address the management of these two concomitant pathologies. Herein, a 69-year-old man who had developed cervical myelopathy 2 years after being affected by isolated dropped head syndrome is presented. Chin to chest deformity and cervical myelopathy were managed through three-level anterior cervical discectomy and fusion (ACDF) combined with decompressive cervical laminectomy and stabilization with C2 to C7 pedicle screw-rod construct. At 4-month follow-up, despite recovery in patient's neurological status, flexion deformity reappeared with recurrence of dropped head due to C7 pedicle screws pull-out. However, this was successfully managed with extension of the construct to the upper thoracic levels. PMID:27034870

  6. Revisiting the Authoritative-Dialogic Tension in Inquiry-Based Elementary Science Teacher Questioning

    NASA Astrophysics Data System (ADS)

    Van Booven, Christopher D.

    2015-05-01

    Building on the 'questioning-based discourse analytical' framework developed by Singapore-based science educator and discourse analyst, Christine Chin, this study investigated the extent to which fifth-grade science teachers' use of questions with either an authoritative or dialogic orientation differentially restricted or expanded the quality and complexity of student responses in the USA. The author analyzed approximately 10 hours of classroom discourse from elementary science classrooms organized around inquiry-based science curricula and texts. Teacher questions and feedback were classified according to their dialogic orientation and contextually inferred structural purpose, while student understanding was operationalized as a dynamic interaction between cognitive process, syntacto-semantic complexity, and science knowledge type. The results of this study closely mirror Chin's and other scholars' findings that the fixed nature of authoritatively oriented questioning can dramatically limit students' opportunities to demonstrate higher order scientific understanding, while dialogically oriented questions, by contrast, often grant students the discursive space to demonstrate a greater breadth and depth of both canonical and self-generated knowledge. However, certain teacher questioning sequences occupying the 'middle ground' between maximal authoritativeness and dialogicity revealed patterns of meaningful, if isolated, instances of higher order thinking. Implications for classroom practice are discussed along with recommendations for future research.

  7. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation.

    PubMed

    Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Quinto-Sánchez, Mirsha; Mendoza-Revilla, Javier; Camilo Chacón-Duque, Juan; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; Pérez, Gastón Macín; Gómez-Valdés, Jorge; Villamil-Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Salzano, Francisco M; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya, Gabriel; Rothhammer, Francisco; Headon, Denis; González-José, Rolando; Balding, David; Ruiz-Linares, Andrés

    2016-05-19

    We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10(-8)) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of ∼3,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.

  8. Dietary exposure of Nigerians to mutagens and estrogen-like chemicals.

    PubMed

    Omoruyi, Iyekhoetin Matthew; Ahamioje, Derek; Pohjanvirta, Raimo

    2014-08-15

    Food and drinking water are poorly delineated sources of human exposure to chemical food mutagens and endocrine-disrupting chemicals. In this study, we investigated the presence of mutagens and chemicals exhibiting estrogenic activity in the daily diet of Nigerians, using in vitro assays. Commercially processed foods or snacks and various brands of pure water sachets were extracted by solid-phase extraction and liquid-liquid extraction, respectively. Mutagenicity was determined by the conventional Ames test and two complementary assays on two strains of Salmonella (TA 100 and TA 98), while the estrogenic activity was assessed by a yeast bioluminescent assay, using two recombinant yeast strains (Saccharomyces cerevisiae BMAEREluc/ERα and S. cerevisiae BMA64/luc). A third of the food varieties investigated (chin-chin, hamburger, suya and bean cake) were mutagenic in all three assays, either in the presence or absence of S9 mix. Of the packed water samples, five out of the sixteen investigated (31%), were found to be estrogenic, with estradiol and bisphenol A equivalents ranging from 0.79 to 44.0 ng/L and 124.2 to 1,000.8 ng/L, respectively. Hence, although the current situation in Nigeria does not appear to be substantially worse than, e.g., in Europe, regular monitoring is warranted in the future.

  9. Comparison of Cyberware PX and PS 3D human head scanners

    NASA Astrophysics Data System (ADS)

    Carson, Jeremy; Corner, Brian D.; Crockett, Eric; Li, Peng; Paquette, Steven

    2008-02-01

    A common limitation of laser line three-Dimensional (3D) scanners is the inability to scan objects with surfaces that are either parallel to the laser line or that self-occlude. Filling in missing areas adds some unwanted inaccuracy to the 3D model. Capturing the human head with a Cyberware PS Head Scanner is an example of obtaining a model where the incomplete areas are difficult to fill accurately. The PS scanner uses a single vertical laser line to illuminate the head and is unable to capture data at top of the head, where the line of sight is tangent to the surface, and under the chin, an area occluded by the chin when the subject looks straight forward. The Cyberware PX Scanner was developed to obtain this missing 3D head data. The PX scanner uses two cameras offset at different angles to provide a more detailed head scan that captures surfaces missed by the PS scanner. The PX scanner cameras also use new technology to obtain color maps that are of higher resolution than the PS Scanner. The two scanners were compared in terms of amount of surface captured (surface area and volume) and the quality of head measurements when compared to direct measurements obtained through standard anthropometry methods. Relative to the PS scanner, the PX head scans were more complete and provided the full set of head measurements, but actual measurement values, when available from both scanners, were about the same.

  10. Unusual complication after genioplasty.

    PubMed

    Avelar, Rafael Linard; Sá, Carlos Diego Lopes; Esses, Diego Felipe Silveira; Becker, Otávio Emmel; Soares, Eduardo Costa Studart; de Oliveira, Rogerio Belle

    2014-01-01

    Facial beauty depends on shape, proportion, and harmony between the facial thirds. The chin is one of the most important components of the inferior third and has an important role on the definition of facial aesthetic and harmony in both frontal and lateral views. There are 2 principal therapeutic approaches that one can choose to treat mental deformities, alloplastic implants, and mental basilar ostectomy, also known as genioplasty. The latest is more commonly used because of great versatility in the correction of three-dimensional deformities of the chin and smaller taxes of postoperative complications. Possible transoperative and postoperative complications of genioplasty include mental nerve lesion, bleeding, damage to tooth roots, bone resorption of the mobilized segment, mandibular fracture, ptosis of the lower lip, and failure to stabilize the ostectomized segment. The study presents 2 cases of displacement of the osteotomized segment after genioplasty associated with facial trauma during postoperative orthognathic surgery followed by rare complications with no reports in the literature. PMID:24621765

  11. Facial growth after primary periosteoplasty versus primary bone grafting in unilateral cleft lip and palate.

    PubMed

    Sameshima, G T; Banh, D S; Smahel, Z; Melnick, M

    1996-07-01

    A cephalometric evaluation of long-term changes resulting from two different surgical techniques for the correction of unilateral cleft lip and palate (UCLP) was undertaken on a sample of 19 males with primary bone grafting, and 42 males with primary periosteoplasty from the Science Academy of the Czech Republic, Prague. Lateral cephalometric radiographs collected at approximately 10 and 15 years of age were traced, digitized, and analyzed using the finite-element method. Facial growth and development between the two groups were compared. Significant differences between the two groups were found in the upper face, the posterior part of the maxilla, the anterior bony chin, and nasal bone areas. The periosteoplasty group demonstrated significantly greater vertical development between anterior cranial base and the maxilla. The bony chin was larger and a greater inferior displacement of the posterior palate were found in the periosteoplasty group. An increased proclination in the nasal bone was observed in the bone graft group. This investigation both confirms the findings of a previous study of these sample populations, and provides additional important details regarding the differences between the groups.

  12. Duplication of 20qter and deletion of 20pter due to paternal pericentric inversion: patient report and review of 20qter duplications.

    PubMed

    Starr, Lois J; Truemper, Edward J; Pickering, Diane L; Sanger, Warren G; Olney, Ann Haskins

    2014-08-01

    Duplications of the terminal long arm of chromosome 20 are rare chromosomal anomalies. We report a male infant found on array comparative genomic hybridization analysis to have a 19.5 Mb duplication of chromosome 20q13.12-13.33, as well as an 886 kb deletion of 20p13 at 18,580-904,299 bp. This anomaly occurred as the recombinant product of a paternal pericentric inversion. There have been 23 reported clinical cases involving 20qter duplications; however, to our knowledge this is only the second reported patient with a paternal pericentric inversion resulting in 46,XY,rec(20)dup(20q). This patient shares many characteristics with previously described patients with 20qter duplications, including microphthalmia, anteverted nares, long ears, cleft palate, small chin, dimpled chin, cardiac malformations, and normal intrauterine growth. While there is variable morbidity in patients with terminal duplications of 20q, a review of previously reported patients and comparison to our patient's findings shows significant phenotypic similarity.

  13. Frequency Distribution and Association of some Morpho- and Physiological Traits in Patients with Lung Diseases in Kosova.

    PubMed

    Alija, Avdulla J; Bajraktari, Ismet D; Bresgen, Nikolaus; Hadziselimovic, Rifat; Beqiraj, Valentina; Selimi, Mimoza; Salihu, Hyrzeme; Mikullovci, Besime; Eckl, Peter M

    2015-12-01

    The aim of this study was to investigate the distribution of specific phenotypes in patients with lung diseases as well as their eventual association with the risk of developing lung diseases. For this purpose 2777 patients with lung diseases and 2778 healthy individuals from all over Kosova were examined for the appearance of the following selected phenotypes: ear lobe free (ELF)/ear lobe attached, normal chin (NC)/cleft chin, tongue roller (TR)/non roller, hand clasping right thumb over (HC)/hand clasping left thumb over, righthanded (RH)/lefthanded. In addition, the blood group from ABO system and the presence or absence of the Rhesus factor asphenotypical markers were observed. The results obtained show significant differences between control and lung disease patients for NC (p ≤ 0.05) and TR (p ≤ 0.005) as well as for blood groups AB (p ≤ 0.05) and O (p ≤ 0.005). These results point to eventually increased levels of genetic load as a result of the increased homozygosity in some gene loci causing an increased frequency of some recessive phenotypes in patients with lung diseases. Together with the specific associations observed, these preliminary findings could serve as a basis for further in depth investigations with respect to the types of lung diseases, occupational exposure and dietary habits, and thus is expected to contribute to an understanding of predispositions and susceptibility to lung diseases.

  14. Evaluation of the 2008 Predictions of Run-Timing and Survival of Wild Migrant Yearling Chinook and Steelhead on the Columbia and Snake Rivers.

    SciTech Connect

    Beer, W. Nicholas; Iltis, Susannah; Anderson, James J.

    2009-01-01

    Columbia Basin Research uses the COMPASS model on a daily basis during the outmigration of Snake River Chinook and steelhead smolts to predict downstream passage and survival. Fish arrival predictions and observations from program RealTime along with predicted and observed environmental conditions are used to make in-season predictions of arrival and survival to various dams in the Columbia and Snake Rivers. For 2008, calibrations of travel and survival parameters for two stocks of fish-Snake River yearling PIT-tagged wild chinook salmon (chin1pit) and Snake River PIT-tagged steelhead (lgrStlhd)-were used to model travel and survival of steelhead and chinook stocks from Lower Granite Dam (LWG) or McNary Dam (MCN) to Bonneville Dam (BON). This report summarizes the success of the COMPASS/RealTime process to model these migrations as they occur. We compared model results on timing and survival to data from two sources: stock specific counts at dams and end-of-season control survival estimates (Jim Faulkner, NOAA, pers. comm. Dec. 16, 2008). The difference between the predicted and observed day of median passage and the Mean Absolute Deviation (MAD) between predicted and observed arrival cumulative distributions are measures of timing accuracy. MAD is essentially the average percentage error over the season. The difference between the predicted and observed survivals is a measure of survival accuracy. Model results and timing data were in good agreement from LWG to John Day Dam (JDA). Predictions of median passage days for the chin1pit and lgrStlhd stocks were 0 and 2 days (respectively) later than observed. MAD for chin1pit and lgrStlhd stocks at JDA were 2.3% and 5.9% (respectively). Between JDA and BON modeling and timing data were not as well matched. At BON, median passage predictions were 6 and 10 days later than observed and MAD values were 7.8% and 16.0% respectively. Model results and survival data were in good agreement from LWG to MCN. COMPASS predicted

  15. Metal and selenium concentrations in blood and feathers of petrels of the genus Procellaria.

    PubMed

    Carvalho, Paloma Calábria; Bugoni, Leandro; McGill, Rona A R; Bianchini, Adalto

    2013-07-01

    Concentrations of copper (Cu), zinc (Zn), cadmium (Cd), lead (Pb), mercury (Hg), and selenium (Se) were determined in blood and feathers of spectacled (Procellaria conspicillata) and white-chinned (Procellaria aequinoctialis) petrels, species that are phylogenetically related, but with distinct ecological niches. In winter, they feed on similar foods, indicated by an overlapping range of whole-blood stable isotopes values (δ(15) N; δ(13) C). No relation was found between blood metal concentration and stable isotope values. In spectacled petrels, metal concentrations appeared lower in blood (Cu = 0.79-20.77 µg/g; Zn = 10.95-28.02 µg/g; Cd = 1.73-10.11 µg/g; Pb = 5.02-26.03 µg/g; Hg = 0.84-9.86 µg/g) than in feathers (Cu = 1.05-21.57 µg/g; Zn = 45.30-81.49 µg/g; Cd = 3.76-10.44 µg/g; Pb = 16.53-59.00 µg/g; Hg = 4.24-24.03 µg/g). In white-chinned petrels, metal concentrations also appeared lower in blood (Cu = 0.62-10.4 µg/g; Zn = 10.73-24.69 µg/g; Cd = 2.00-6.31 µg/g; Pb = 5.72-24.03 µg/g) than in feathers (Cu = 2.68-23.92 µg/g; Zn = 48.96-93.54 µg/g; Cd = 5.72-24.03 µg/g; Pb = 18.62-55.51 µg/g), except for Hg (blood = 0.20-15.82 µg/g; feathers = 0.19-8.91 µg/g). Selenium (0.24-14.18 µg/g) and Hg (0.22-1.44 µg/g) concentrations showed a positive correlation in growing feathers of spectacled petrels. Blood and feather Hg levels were higher in spectacled petrels while feathers Cu and Zn concentrations were greater in white-chinned petrels. Juvenile white-chinned petrels exhibited greater blood Hg concentrations than adults. In the south Atlantic Ocean, discards from commercial fishing operations consumed by spectacled petrels year-round and by white-chinned petrels during the wintering period have elevated Hg concentrations. Because Hg toxicity is associated with behavioral and reproductive changes in birds, it could

  16. Osseous genioplasty: A case series

    PubMed Central

    Deshpande, Sanjeev N.; Munoli, Amarnath V.

    2011-01-01

    Introduction: The chin (mentum) is vital to the human facial morphology as it contributes to the facial aesthetics and harmony both on frontal and lateral views. Osseous genioplasty, the alteration of the chin through skeletal modification, can lead to significant enhancement of the overall facial profile. Aim and Study Design: A case series was designed to study the long-term results of osseous genioplasty in Indian patients with regard to patient satisfaction, complications, and long-term stability. Materials and Methods: All subjects who underwent osseous genioplasty either alone or as a component of orthognathic surgery between January 1992 and December 2010, with a minimum follow-up of 2 years, were included. The genioplasty was performed using standard protocols of assessment and execution. Post-operative evaluation included patient satisfaction, complications and radiological evidence of long-term stability. A comprehensive score was formulated for the purpose of the study. Results: Thirty-seven subjects underwent osseous genioplasty with at least 2 years of follow-up in the study period. This included 17 male and 20 female subjects, with a mean age of 22.8 years (15-52 years) and a mean follow-up of 3 years 4 months (2 years to 4 years and 11 months). Nineteen subjects underwent isolated genioplasty while 18 underwent genioplasty as a part of orthognathic surgery. The procedures included advancement (22), pushback (9), side-to-side (4) and vertical reduction (2) genioplasty. Thirty-six subjects (97.3%) were extremely pleased with the results with only one subject expressing reservations, without, however, demanding any further procedure. There were no significant complications. The osteotomised segment was well maintained in its new position with good bony union and minimal resorption. Overall, 35 (94.6%) cases had excellent results and 2 (4.4%) cases had good results, according to the comprehensive score. Conclusions: Osseous genioplasty is a safe and

  17. IR/UV laser spectroscopy of secondary structures in isolated peptide chains: an original insight onto the non-covalent interactions that shape proteins

    NASA Astrophysics Data System (ADS)

    Gloaguen, Eric

    2009-03-01

    Protein shape and flexibility is governed by non-covalent interactions that need to be accurately described by molecular structure simulations. However, the computational methods adapted for large molecules like proteins have difficulties to reproduce precisely these non-covalent interactions and cannot reach the level of structural details required to address many biological relevant issues. Special efforts are currently done to document these interactions by carrying out experiments on simple model systemsootnotetextJ.-P. Schermann, Spectroscopy and modeling of biomolecular building blocks. (Elsevier, 2007). in order to help the development of reliable DFT-D calculationsootnotetextP. Jurecka, J. Cerny, P. Hobza, and D. R. Salahub, J. Comput. Chem. 28 (2), 555 (2007); S. Grimme, J. Comput. Chem. 27 (15), 1787 (2006). and polarisable force fields explorations.ootnotetextN. Gresh, G. A. Cisneros, T. A. Darden, and J. P. Piquemal, Journal of Chemical Theory and Computation 3 (6), 1960 (2007). The selectivity of the IR/UV double resonance spectroscopy of gas phase isolated peptides (less than 10 residues) laser desorbed and cooled in a molecular beam enables us to discriminate the spectral signature of the several H-bonds shaping the molecular conformation. This can be carried out for each conformation detected in the molecular beam, providing a precise IR fingerprint of the intramolecular hydrogen bond network of these moleculesootnotetextW. Chin, F. Piuzzi, I. Dimicoli, and M. Mons, Phys. Chem. Chem. Phys. 8, 1 (2006); W. Chin, M. Mons, J.-P. Dognon, F. Piuzzi, B. Tardivel, and I. Dimicoli, Phys. Chem. Chem. Phys. 6, 2700 (2004); E. Gloaguen, F. Pagliarulo, V. Brenner, W. Chin, F. Piuzzi, B. Tardivel, and M. Mons, PCCP 9, 4491 (2007).^ and references therein These IR frequencies are directly compared to the calculated frequencies of selected conformations of the isolated molecule for assignment purpose. Once the experimentally observed conformations are known, the

  18. Hormonal and behavioral changes induced by acute and chronic experimental infestation with Psoroptes cuniculi in the domestic rabbit Oryctolagus cuniculus

    PubMed Central

    2013-01-01

    Background Parasitic diseases are important in animal production because they cause high economic losses. Affected animals often exhibit stereotypical behavioral alterations such as anorexia and inactivity, among others. Among the diseases that commonly affect domestic rabbits is mange, which is caused by the mite Psoroptes cuniculi. Therefore, within the context of the host-parasite relationship, it is critical to understand the mechanisms involved in the alteration of host behavior, in order to better utilize sick animal behavior as a strategy for diagnosis and treatment of disease. Methods Rabbits were infested placing mites in the ear conduct. We characterized changes in exploratory behavior and scent marking evoked by acute (1-9 days) and chronic (25-33 days) experimental infestation. Behavior was recorded during ten minutes while the animals were in a 120 cm × 120 cm open field arena divided into 9 squares. Serum cortisol was measured individually using radioimmunoassay kits. Locomotor activity, chinning, rearing and body weight were compared using a Friedman test, the effect of treatment (infested versus non-infested) across time was analyzed using a repeated measures ANOVA, and the Pearson test was used to determine whether chinning and ambulation scores were significantly correlated. Serum cortisol levels and food consumption were analyzed with a Kruskal-Wallis test and body temperature was analyzed with an ANOVA test. Results We observed a significant decrease in rearing behavior as early as two days post-infestation, while chinning and locomotor activity were significantly decreased four days post-infestation. Chronic infestation was associated with decreased food intake, significant weight loss, and a trend toward increased serum cortisol levels, while no changes were observed in body temperature. Conclusions The presence of visible lesions within the ear canal is commonly used to detect mite infestation in rabbits, but this is possible only after

  19. Intracortical and Thalamocortical Connections of the Hand and Face Representations in Somatosensory Area 3b of Macaque Monkeys and Effects of Chronic Spinal Cord Injuries.

    PubMed

    Chand, Prem; Jain, Neeraj

    2015-09-30

    Brains of adult monkeys with chronic lesions of dorsal columns of spinal cord at cervical levels undergo large-scale reorganization. Reorganization results in expansion of intact chin inputs, which reactivate neurons in the deafferented hand representation in the primary somatosensory cortex (area 3b), ventroposterior nucleus of the thalamus and cuneate nucleus of the brainstem. A likely contributing mechanism for this large-scale plasticity is sprouting of axons across the hand-face border. Here we determined whether such sprouting takes place in area 3b. We first determined the extent of intrinsic corticocortical connectivity between the hand and the face representations in normal area 3b. Small amounts of neuroanatomical tracers were injected in these representations close to the electrophysiologically determined hand-face border. Locations of the labeled neurons were mapped with respect to the detailed electrophysiological somatotopic maps and histologically determined hand-face border revealed in sections of the flattened cortex stained for myelin. Results show that intracortical projections across the hand-face border are few. In monkeys with chronic unilateral lesions of the dorsal columns and expanded chin representation, connections across the hand-face border were not different compared with normal monkeys. Thalamocortical connections from the hand and face representations in the ventroposterior nucleus to area 3b also remained unaltered after injury. The results show that sprouting of intrinsic connections in area 3b or the thalamocortical inputs does not contribute to large-scale cortical plasticity. Significance statement: Long-term injuries to dorsal spinal cord in adult primates result in large-scale somatotopic reorganization due to which chin inputs expand into the deafferented hand region. Reorganization takes place in multiple cortical areas, and thalamic and medullary nuclei. To what extent this brain reorganization due to dorsal column injuries

  20. Intracortical and Thalamocortical Connections of the Hand and Face Representations in Somatosensory Area 3b of Macaque Monkeys and Effects of Chronic Spinal Cord Injuries.

    PubMed

    Chand, Prem; Jain, Neeraj

    2015-09-30

    Brains of adult monkeys with chronic lesions of dorsal columns of spinal cord at cervical levels undergo large-scale reorganization. Reorganization results in expansion of intact chin inputs, which reactivate neurons in the deafferented hand representation in the primary somatosensory cortex (area 3b), ventroposterior nucleus of the thalamus and cuneate nucleus of the brainstem. A likely contributing mechanism for this large-scale plasticity is sprouting of axons across the hand-face border. Here we determined whether such sprouting takes place in area 3b. We first determined the extent of intrinsic corticocortical connectivity between the hand and the face representations in normal area 3b. Small amounts of neuroanatomical tracers were injected in these representations close to the electrophysiologically determined hand-face border. Locations of the labeled neurons were mapped with respect to the detailed electrophysiological somatotopic maps and histologically determined hand-face border revealed in sections of the flattened cortex stained for myelin. Results show that intracortical projections across the hand-face border are few. In monkeys with chronic unilateral lesions of the dorsal columns and expanded chin representation, connections across the hand-face border were not different compared with normal monkeys. Thalamocortical connections from the hand and face representations in the ventroposterior nucleus to area 3b also remained unaltered after injury. The results show that sprouting of intrinsic connections in area 3b or the thalamocortical inputs does not contribute to large-scale cortical plasticity. Significance statement: Long-term injuries to dorsal spinal cord in adult primates result in large-scale somatotopic reorganization due to which chin inputs expand into the deafferented hand region. Reorganization takes place in multiple cortical areas, and thalamic and medullary nuclei. To what extent this brain reorganization due to dorsal column injuries

  1. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life.

    PubMed

    Ranieri, M; Sciuscio, M; Cortese, A M; Santamato, A; Di Teo, L; Ianieri, G; Bellomo, R G; Stasi, M; Megna, M

    2009-01-01

    The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) and the beneficial effect of physical exercise on positive sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict. Often these painful syndromes after the acute event, tend to recurr becoming subacute or chronic syndromes that become for the period of interest disabiling is an event very important in these cases proper prevention, based on a maintenance drug therapy and the strengthening exercises of paravertebral muscles, flexibility exercises on the spine and when needed on the reduction of body weight. In this Observational Cohort, two-arm trial, 203 patients were enrolled and divided into two groups, the first, ALA and GLA group, (n = 101) received oral dose of 600 mg of alpha-lipoic acid (ALA) and 360 mg of gamma-linolenic acid (GLA) and a rehabilitation program for six weeks, the second (n = 102) treated with only rehabilitation program. Patients were recruited at the centre of Physical Medicine and Rehabilitation, they underwent a physiatric examination at the primary outcome (t0) and secondary outcomes were recorded at monitoring visits scheduled at two weeks = t1, four weeks = t2, six weeks = t3, and at the same has been administered the following scale: VAS scale, SF-36, Oswestry Low Back Pain Disability Questionnaire, Aberdeen Back Pain Scale (ABPS), Revised Leeds Disability Questionnaire (LDQ), Roland and Morris Disability Questionnaire. Significant improvements was noted in the ALA and GLA group for paresthesia, stabbing and burning pain, as showed by VAS (Visual Analogue Scale), Oswestry Low Back Pain Disability Questionnaire, Aberdeen Low Back Pain Scale; also, improvements of quality of life has been noted, in the same group, as showed by SF-36, LDQ (Revised Leeds Disability Questionnaire), Roland and Morris disability questionnaire. All these outcome measure showed statistically

  2. Nineteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Horne, R.J.; Kruger, P.; Miller, F.G.; Brigham, W.E.; Cook, J.W.

    1994-01-20

    PREFACE The Nineteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 18-20, 1994. This workshop opened on a sad note because of the death of Prof. Henry J. Ramey, Jr. on November 19, 1993. Hank had been fighting leukemia for a long time and finally lost the battle. Many of the workshop participants were present for the celebration of his life on January 21 at Stanford's Memorial Church. Hank was one of the founders of the Stanford Geothermal Program and the Geothermal Reservoir Engineering Workshop. His energy, kindness, quick wit, and knowledge will long be missed at future workshops. Following the Preface we have included a copy of the Memorial Resolution passed by the Stanford University Senate. There were one hundred and four registered participants. Participants were from ten foreign countries: Costa Rica, England, Iceland, Italy, Japan, Kenya, Mexico, New Zealand, Philippines and Turkey. Workshop papers described the performance of fourteen geothermal fields outside the United States. Roland N. Home opened the meeting and welcomed the visitors to the campus. The key note speaker was J.E. ''Ted'' Mock who gave a presentation about the future of geothermal development. The banquet speaker was Jesus Rivera and he spoke about Energy Sources of Central American Countries. Forty two papers were presented at the Workshop. Technical papers were organized in twelve sessions concerning: sciences, injection, production, modeling, and adsorption. Session chairmen are an important part of the workshop and our thanks go to: John Counsil, Mark Walters, Dave Duchane, David Faulder, Gudmundur Bodvarsson, Jim Lovekin, Joel Renner, and Iraj Ershaghi. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes for publication. We owe a great deal of thanks to our students who operate audiovisual

  3. A pilot randomized controlled trial comparing the efficacy of exercise, spinal manipulation, and neuro emotional technique for the treatment of pregnancy-related low back pain

    PubMed Central

    2012-01-01

    Background This pilot randomized controlled trial evaluated the feasibility of conducting a full scale study and compared the efficacy of exercise, spinal manipulation, and a mind-body therapy called Neuro Emotional Technique for the treatment of pregnancy-related low back pain, a common morbidity of pregnancy. Methods Healthy pregnant women with low back pain of insidious onset were eligible to enroll in the study at any point in their pregnancy. Once enrolled, they remained in the study until they had their babies. Women were randomly allocated into one of three treatment groups using opaque envelopes. The treatment schedule paralleled the prenatal care schedule and women received individualized intervention. Our null hypothesis was that spinal manipulation and Neuro Emotional Technique would perform no better than exercise in enhancing function and decreasing pain. Our primary outcome measure was the Roland Morris Disability Questionnaire and our secondary outcome measure was the Numeric Pain Rating Scale. Intention to treat analysis was conducted. For the primary analysis, regression was conducted to compare groups on the outcome measure scores. In a secondary responder analysis, difference in proportions of participants in attaining 30% and 50% improvement were calculated. Feasibility factors for conducting a future larger trial were also evaluated such as recruitment, compliance to study protocols, cost, and adverse events. Results Fifty-seven participants were randomized into the exercise (n = 22), spinal manipulation (n = 15), and Neuro Emotional Technique (n = 20) treatment arms. At least 50% of participants in each treatment group experienced clinically meaningful improvement in symptoms for the Roland Morris Disability Questionnaire. At least 50% of the exercise and spinal manipulation participants also experienced clinically meaningful improvement for the Numeric Pain Rating Scale. There were no clinically meaningful or statistically

  4. Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.

    PubMed

    Tozzi, Leonardo; Carballedo, Angela; Wetterling, Friedrich; McCarthy, Hazel; O'Keane, Veronica; Gill, Michael; Morris, Derrek; Fahey, Ciara; Meaney, James; Frodl, Thomas

    2016-01-01

    The gene expressing the FK506 binding protein 51 (FKBP5) is involved in the regulation of glucocorticoid receptor sensitivity. The rs1360780 SNP in this gene (T allele vs C homozygous) has been found to be associated with major depressive disorder (MDD). The aim of our study was to investigate whether this polymorphism might be associated with altered brain structure and function in a cohort of 40 patients with MDD and 43 healthy controls. A functional magnetic resonance imaging (fMRI) emotional attention task was employed. Diffusion tensor imaging (DTI) was also conducted, extracting mean diffusivity (MD) and fractional anisotropy (FA) from brain areas that showed functional differences between patients expressing the two alleles of the rs1360780 SNP. Finally, the effect of the interaction of childhood adversity as measured by the Childhood trauma Questionnaire (CTQ) and rs1360780 allele status was analyzed in relation to DTI measures using a general linear model. All results presented are family-wise error (FWE) corrected. Functional interactions were found between genotype and diagnosis (p<0.01). Patients carrying the high-risk allele, compared with patients not carrying it, showed reduced activity in the rolandic operculum, Heschl gyrus, insula, parahippocampal gyrus, posterior cingulate cortex, inferior frontal gyrus (p<0.05 for all measures); and increased MD and reduced FA measures in many of these regions (p<0.05). An interaction between CTQ scores and allele status was associated with DTI changes in the insula, rolandic operculum, and inferior frontal gyrus. Here, the presence of both the high-risk allele and higher CTQ scores was associated with higher MD and lower FA values (p<0.05). In conclusion, MDD patients expressing the T allele of rs1360780, compared with C homozygous patients, exhibit functional and structural differences in areas involved in emotional perception and inhibition. The interaction between the T allele and childhood maltreatment

  5. Sixteenth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.; Miller, F.G.; Horne, R.N.; Brigham, W.E.; Cook, J.W.

    1991-01-25

    The Sixteenth Workshop on Geothermal Reservoir Engineering was held at Stanford University on January 23-25, 1991. The Workshop Banquet Speaker was Dr. Mohinder Gulati of UNOCAL Geothermal. Dr. Gulati gave an inspiring talk on the impact of numerical simulation on development of geothermal energy both in The Geysers and the Philippines. Dr. Gulati was the first recipient of The Stanford Geothermal Program Reservoir Engineering Award for Excellence in Development of Geothermal Energy. Dr. Frank Miller presented the award. The registered attendance figure of one hundred fifteen participants was up slightly from last year. There were seven foreign countries represented: Iceland, Italy, Philippines, Kenya, the United Kingdom, Mexico, and Japan. As last year, papers on about a dozen geothermal fields outside the United States were presented. There were thirty-six papers presented at the Workshop, and two papers were submitted for publication only. Attendees were welcomed by Dr. Khalid Aziz, Chairman of the Petroleum Engineering Department at Stanford. Opening remarks were presented by Dr. Roland Horne, followed by a discussion of the California Energy Commission's Geothermal Activities by Barbara Crowley, Vice Chairman; and J.E. ''Ted'' Mock's presentation of the DOE Geothermal Program: New Emphasis on Industrial Participation. Technical papers were organized in twelve sessions concerning: hot dry rock, geochemistry, tracer injection, field performance, modeling, and chemistry/gas. As in previous workshops, session chairpersons made major contributions to the program. Special thanks are due to Joel Renner, Jeff Tester, Jim Combs, Kathy Enedy, Elwood Baldwin, Sabodh Garg, Marcel0 Lippman, John Counsil, and Eduardo Iglesias. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank Pat Ota, Angharad Jones, Rosalee Benelli, Jeanne Mankinen, Ted Sumida, and Terri A. Ramey who also produces the Proceedings Volumes

  6. 3D model of radionuclide dispersion in coastal areas with multifraction cohesive and non-cohesive sediments

    NASA Astrophysics Data System (ADS)

    Brovchenko, Igor; Maderich, Vladimir; Jung, Kyung Tae

    2015-04-01

    We developed new radionuclide dispersion model that may be used in coastal areas, rivers and estuaries with non-uniform distribution of suspended and bed sediments both cohesive and non-cohesive types. Model describes radionuclides concentration in dissolved phase in water column, particulated phase on suspended sediments on each sediment class types, bed sediments and pore water. The transfer of activity between the water column and the pore water in the upper layer of the bottom sediment is governed by diffusion processes. The phase exchange between dissolved and particulate radionuclides is written in terms of desorption rate a12 (s-1) and distribution coefficient Kd,iw and Kd,ib (m3/kg) for water column and for bottom deposit, respectively. Following (Periáñez et al., 1996) the dependence of distribution coefficients is inversely proportional to the sediment particle size. For simulation of 3D circulation, turbulent diffusion and wave fields a hydrostatic model SELFE (Roland et. al. 2010) that solves Reynolds-stress averaged Navier-Stokes (RANS) equations and Wave Action transport equation on the unstructured grids was used. Simulation of suspended sediment concentration and bed sediments composition is based on (L. Pinto et. al., 2012) approach that originally was developed for non-cohesive sediments. In present study we modified this approach to include possibility of simulating mixture of cohesive and non-cohesive sediments by implementing parameterizations for erosion and deposition fluxes for cohesive sediments and by implementing flocculation model for determining settling velocity of cohesive flocs. Model of sediment transport was calibrated on measurements in the Yellow Sea which is shallow tidal basin with strongly non-uniform distribution of suspended and bed sediments. Model of radionuclide dispersion was verified on measurements of 137Cs concentration in surface water and bed sediments after Fukushima Daiichi nuclear accident. References Peri

  7. The SNAP trial: a double blind multi-center randomized controlled trial of a silicon nitride versus a PEEK cage in transforaminal lumbar interbody fusion in patients with symptomatic degenerative lumbar disc disorders: study protocol

    PubMed Central

    2014-01-01

    Background Polyetheretherketone (PEEK) cages have been widely used in the treatment of lumbar degenerative disc disorders, and show good clinical results. Still, complications such as subsidence and migration of the cage are frequently seen. A lack of osteointegration and fibrous tissues surrounding PEEK cages are held responsible. Ceramic implants made of silicon nitride show better biocompatible and osteoconductive qualities, and therefore are expected to lower complication rates and allow for better fusion. Purpose of this study is to show that fusion with the silicon nitride cage produces non-inferior results in outcome of the Roland Morris Disability Questionnaire at all follow-up time points as compared to the same procedure with PEEK cages. Methods/Design This study is designed as a double blind multi-center randomized controlled trial with repeated measures analysis. 100 patients (18–75 years) presenting with symptomatic lumbar degenerative disorders unresponsive to at least 6 months of conservative treatment are included. Patients will be randomly assigned to a PEEK cage or a silicon nitride cage, and will undergo a transforaminal lumbar interbody fusion with pedicle screw fixation. Primary outcome measure is the functional improvement measured by the Roland Morris Disability Questionnaire. Secondary outcome parameters are the VAS leg, VAS back, SF-36, Likert scale, neurological outcome and radiographic assessment of fusion. After 1 year the fusion rate will be measured by radiograms and CT. Follow-up will be continued for 2 years. Patients and clinical observers who will perform the follow-up visits will be blinded for type of cage used during follow-up. Analyses of radiograms and CT will be performed independently by two experienced radiologists. Discussion In this study a PEEK cage will be compared with a silicon nitride cage in the treatment of symptomatic degenerative lumbar disc disorders. To our knowledge, this is the first randomized controlled

  8. Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex

    PubMed Central

    Roll, Patrice; Vernes, Sonja C.; Bruneau, Nadine; Cillario, Jennifer; Ponsole-Lenfant, Magali; Massacrier, Annick; Rudolf, Gabrielle; Khalife, Manal; Hirsch, Edouard; Fisher, Simon E.; Szepetowski, Pierre

    2010-01-01

    It is a challenge to identify the molecular networks contributing to the neural basis of human speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech (developmental verbal dyspraxia, DVD), whereas mutations of sushi-repeat protein SRPX2 lead to epilepsy of the rolandic (sylvian) speech areas, with DVD or with bilateral perisylvian polymicrogyria. Pathophysiological mechanisms driven by SRPX2 involve modified interaction with the plasminogen activator receptor (uPAR). Independent chromatin-immunoprecipitation microarray screening has identified the uPAR gene promoter as a potential target site bound by FOXP2. Here, we directly tested for the existence of a transcriptional regulatory network between human FOXP2 and the SRPX2/uPAR complex. In silico searches followed by gel retardation assays identified specific efficient FOXP2-binding sites in each of the promoter regions of SRPX2 and uPAR. In FOXP2-transfected cells, significant decreases were observed in the amounts of both SRPX2 (43.6%) and uPAR (38.6%) native transcripts. Luciferase reporter assays demonstrated that FOXP2 expression yielded a marked inhibition of SRPX2 (80.2%) and uPAR (77.5%) promoter activity. A mutant FOXP2 that causes DVD (p.R553H) failed to bind to SRPX2 and uPAR target sites and showed impaired down-regulation of SRPX2 and uPAR promoter activity. In a patient with polymicrogyria of the left rolandic operculum, a novel FOXP2 mutation (p.M406T) was found in the leucine-zipper (dimerization) domain. p.M406T partially impaired the FOXP2 regulation of SRPX2 promoter activity, whereas that of the uPAR promoter remained unchanged. Together with recently described FOXP2-CNTNAP2 and SRPX2/uPAR links, the FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders. PMID:20858596

  9. Mixed Form of Hirsutism in an Adolescent Female and Laser Therapy

    PubMed Central

    Gacaferri Lumezi, Besa; Goci, Aferdita; Lokaj, Violeta; Latifi, Hatixhe; Karahoda, Natyra; Minci, Ganimete; Telaku, Drita; Gercari, Antigona; Kocinaj, Allma

    2014-01-01

    Introduction: Hirsutism is a common disorder of excess growth of terminal hair in an androgen-dependent male distribution in women, including the chin, upper lip, breasts, back, and abdomen. It is very important to identify the etiology of hirsutism and adequate treat is prior to any cosmetic therapy. Case Presentation: The case was a 17-year-old female with severe hirsutism, oligomenorrhea, and obesity. She was evaluated to identify the etiology and diagnosed as a case of polycystic ovarian syndrome (PCOS), nonclassic congenital adrenal hyperplasia (NC-CAH), and hyperandrogenic insulin-resistant acanthosis nigricans (HAIR-AN) syndrome, which is a rare combination of hirsutism etiology. She was successfully treated according to the underlying pathology, and laser photoepilation was used as the preferred hair removal method. Discussion: Establishing the etiology, using the evidence–based strategies to improve hirsutism, and treating the underlying disorder, are essential for proper management of women with hirsutism. PMID:25068069

  10. SplitRFLab: A MATLAB GUI toolbox for receiver function analysis based on SplitLab

    NASA Astrophysics Data System (ADS)

    Xu, Mijian; Huang, Hui; Huang, Zhouchuan; Wang, Liangshu

    2016-02-01

    We add new modules for receiver function (RF) analysis in SplitLab toolbox, which includes the manual RF analysis module, automatic RF analysis and related quality control modules, and H- k stacking module. The updated toolbox (named SplitRFLab toolbox), especially its automatic RF analysis module, could calculate the RFs quickly and efficiently, which is very useful in RF analysis with huge amount of seismic data. China is now conducting the ChinArray project that plans to deploy thousands of portable stations across Chinese mainland. Our SplitRFLab toolbox may obtain reliable RF results quickly at the first time, which provide essentially new constraint to the crustal and mantle structures.

  11. Direct Measurement of the Mass Difference of (163)Ho and (163)Dy Solves the Q-Value Puzzle for the Neutrino Mass Determination.

    PubMed

    Eliseev, S; Blaum, K; Block, M; Chenmarev, S; Dorrer, H; Düllmann, Ch E; Enss, C; Filianin, P E; Gastaldo, L; Goncharov, M; Köster, U; Lautenschläger, F; Novikov, Yu N; Rischka, A; Schüssler, R X; Schweikhard, L; Türler, A

    2015-08-01

    The atomic mass difference of (163)Ho and (163)Dy has been directly measured with the Penning-trap mass spectrometer SHIPTRAP applying the novel phase-imaging ion-cyclotron-resonance technique. Our measurement has solved the long-standing problem of large discrepancies in the Q value of the electron capture in (163)Ho determined by different techniques. Our measured mass difference shifts the current Q value of 2555(16) eV evaluated in the Atomic Mass Evaluation 2012 [G. Audi et al., Chin. Phys. C 36, 1157 (2012)] by more than 7σ to 2833(30(stat))(15(sys)) eV/c(2). With the new mass difference it will be possible, e.g., to reach in the first phase of the ECHo experiment a statistical sensitivity to the neutrino mass below 10 eV, which will reduce its present upper limit by more than an order of magnitude.

  12. Realization of the ergonomics design and automatic control of the fundus cameras

    NASA Astrophysics Data System (ADS)

    Zeng, Chi-liang; Xiao, Ze-xin; Deng, Shi-chao; Yu, Xin-ye

    2012-12-01

    The principles of ergonomics design in fundus cameras should be extending the agreeableness by automatic control. Firstly, a 3D positional numerical control system is designed for positioning the eye pupils of the patients who are doing fundus examinations. This system consists of a electronically controlled chin bracket for moving up and down, a lateral movement of binocular with the detector and the automatic refocusing of the edges of the eye pupils. Secondly, an auto-focusing device for the object plane of patient's fundus is designed, which collects the patient's fundus images automatically whether their eyes is ametropic or not. Finally, a moving visual target is developed for expanding the fields of the fundus images.

  13. Morbid obesity in a child with monosomy 1p36 syndrome

    PubMed Central

    Zagalo, Ana; Dias, Patricia; Pereira, Carla; Sampaio, Maria de Lurdes

    2012-01-01

    The monosomy 1p36 syndrome is a cause of syndromic obesity. It is characterised by psychomotor delay, hypotonia and typical craniofacial dysmorphism. Other features commonly associated are behavioural anomalies including hyperphagia and self-injuring, seizures, congenital heart disease and hypothyroidism. The authors report the case of a 9-year and 5-month-boy referred to the paediatric endocrinology clinics for morbid obesity. Clinical findings were generalised obesity with a body mass index >95th centile, acanthosis nigricans of the neck, arms with self inflicted lesions, deep-set eyes, straight eyebrows, broad nasal bridge and pointed chin. He was unable to walk and had no expressive language. Cytogenetic analysis identified 1p36.33-pter deletion (~139 Mb terminal deletion in chromosome 1 short arm) and Y chromosome duplication. The blood analysis showed insulin resistance and dyslipidaemia. The authors emphasise the need to consider monosomy 1p36 as a cause of severe psychomotor delay and obesity. PMID:22605691

  14. Some psychological considerations on the behavior of the human eye in the case of an irradiation from a monochromatic optical device

    NASA Astrophysics Data System (ADS)

    Reidenbach, Hans-Dieter

    2005-04-01

    In investigations of the eye blink reflex it was found that there exists a dependence on the wavelength of the applied laser device considering the frequency of this physiological reaction. The experimentally acquired correlation shows a much weaker association with the V(λ)-curve than it is normally valid for photobic vision. The experimentally obtained results might be explained by the well-known fundamental WEBER-FECHNER-law of psychophysics and will be given as a blink reflex function in accordance with the STEVENS power law. The results of 788 measurements at 670 nm, 635 nm and 532 nm in lab and field trials in which the head of the tested volunteers was fixed on a chin rest were confirmed in two additionally performed studies with 516 volunteers with an unrestrained head in which either a direct intrabeam viewing or an eye-tracking method was applied in order to simulate typical irradiation situations.

  15. The first case of Niikawa-Kuroki syndrome in Kazakhstan associated with café au lait spots.

    PubMed

    Al Mosawi, A J; Fewin, L

    2009-10-01

    Niikawa-Kuroki syndrome (Kabuki syndrome) is a multiple congenital anomaly syndrome of unknown etiology with a very wide spectrum of abnormalities and severity. The aim of this paper was to report the first case of the syndrome in Kazakhstan associated café au lait. Five year and half old boy from Kazakhstan (Uzbek-of Turk ethnicity) presented with dysmorphic facial features (long palpebral fissures, a broad and depressed nasal tip, large prominent earlobes, small head, epicanthic folds short stature, delayed language development, hypotonia, bilateral developmental dysplasia of the hip (DDH), large ears and triangular chin, café au lait spots. The clinical diagnosis was based on the triad of characteristic facial abnormalities (long palpebral fissures, a broad and depressed nasal tip, large prominent earlobes, small head), growth retardation, (DDH). In this paper the authors report the first case of Kabuki syndrome associated with café au lait spots.

  16. The Burmese medic: an international physician assistant analogue.

    PubMed

    Pedersen, Donald M; Pedersen, Kathy J; Santitamrongpan, Verapan

    2012-01-01

    Although there have been recent democratic reforms in Myanmar (formerly known as Burma), for nearly 60 years there has been a consistent history of human rights violations as part of a civil war waged by the Myanmar military, known as the Tatmadaw. Approximately 3,500 villages have been destroyed by the Tatmadaw during the half-century of civil war. Oppression against minority groups, including the Karen, Karenni, Kachin, Mon, Shan, Chin, and Muslims has adversely affected the health outcomes of these vulnerable populations. Since the mid 1990s, medics have been providing care for the ethnic minorities who were displaced from their homes by the civil war and who live in the jungles of eastern Burma as well as in the refugee camps and towns in the border areas of Thailand. This article will look at how these medics are providing care similar to that provided by physician assistants in the United States.

  17. Intravenous methylprednisolone pulse therapy in ankylosing spondylitis.

    PubMed

    Ejstrup, L; Peters, N D

    1985-08-01

    For several years the medical treatment of active ankylosing spondylitis (AS) has been NSAID because gold, penicillamine, antimalarials and steroids have been without efficacy. In 1981, Mintz et al reported that methylprednisolone pulse therapy (MPPT) had an excellent effect in patients with AS. Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days. Mobility and pain were recorded before, during, and after treatment. Significant pain relief and improvement of mobility of the spine for at least six weeks were clearly demonstrated (p less than 0.05). Finger to floor distance and chin manubrium distance improved significantly for at least six months (p less than 0.05). We conclude that intravenous MPPT is a useful treatment in patients with active AS when NSAID is insufficient. PMID:4042697

  18. Extrapolated gradientlike algorithms for molecular dynamics and celestial mechanics simulations.

    PubMed

    Omelyan, I P

    2006-09-01

    A class of symplectic algorithms is introduced to integrate the equations of motion in many-body systems. The algorithms are derived on the basis of an advanced gradientlike decomposition approach. Its main advantage over the standard gradient scheme is the avoidance of time-consuming evaluations of force gradients by force extrapolation without any loss of precision. As a result, the efficiency of the integration improves significantly. The algorithms obtained are analyzed and optimized using an error-function theory. The best among them are tested in actual molecular dynamics and celestial mechanics simulations for comparison with well-known nongradient and gradient algorithms such as the Störmer-Verlet, Runge-Kutta, Cowell-Numerov, Forest-Ruth, Suzuki-Chin, and others. It is demonstrated that for moderate and high accuracy, the extrapolated algorithms should be considered as the most efficient for the integration of motion in molecular dynamics simulations. PMID:17025782

  19. A new species of Satyrichthys (Teleostei: Peristediidae) from the Maldives Archipelago (Indian Ocean).

    PubMed

    Pogoreutz, Claudia; Vitecek, Simon; Ahnelt, Harald

    2013-01-01

    A new species of the genus Satyrichthys, Satyrichthys kikingeri sp. nov., is described from the Rasdhoo Atoll, Maldives Archipelago. The new species is placed in a group of Satyrichthys with at least three lip barbels and unequal parietal bones. It differs from its congeners in the combination of the following characters: (1) 3/3 lip and 1/0 chin barbels, (2) 15 fin rays in the second dorsal fin, 13 fin rays in the anal fin, (3) 25 bony plates in the dorsal, 29 in the upper lateral and 20 in the lower lateral rows, (4) 21st to 28th bony plates in the upper lateral row with forward directed spines and (5) parietal bones unequal in size on midline. Satyrichthys kikingeri sp. nov. is the first Satyrichthys species reported from the Republic of the Maldives. PMID:26312277

  20. [Pathogenesis, clinical picture, and current therapy of rosacea].

    PubMed

    Gonser, L I; Gonser, C E; Schaller, M

    2016-01-01

    Rosacea is a common chronic inflammatory disease, especially in patients with fair skin and positive family history. Typical locations are forehead, nose, cheeks and chin; the periorbital region is usually not involved. Clinical features can be very heterogeneous. Besides different subtypes (erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea), which often overlap, various special forms of rosacea exist. Up to 60% of patients with cutaneous rosacea suffer from ocular rosacea. In Germany, brimonidine, metronidazol, azelaic acid, and ivermectin are approved for topical therapy of rosacea; for systemic therapy, doxycycline at a subantimicrobial dose (40 mg/day) is the only approved substance. In case of resistance to this therapy, contraindications or side effects, various alternative therapies are available, however off-label. PMID:26669873