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Sample records for royal netherlands institute

  1. Digitising the Past: The Beginning of a New Future at the Royal Tropical Institute of The Netherlands

    ERIC Educational Resources Information Center

    Levi, Peter

    2010-01-01

    Purpose: The purpose of this paper is to describe a project to digitise maps at the Royal Tropical Institute, or Koninklijk Instituut voor de Tropen (KIT), of The Netherlands. KIT has an extensive collection of maps and nautical charts of (sub-) tropical regions, including general maps and topographical map series, city maps, thematic maps and…

  2. Je Maintiendrai: The Royal Netherlands Army Within the Alliance

    DTIC Science & Technology

    1989-06-01

    participated in combat from 1950 13 to 1953. 23 Tensions between the Netherlands and Indonesia resulted in several armed confrontations between the Dutch Army...van Hoof, "Fortifications in the Netherlands (c. 1500-1940)," Je Maintiendrai., 197-123; and Gerald Newton, The Netherlands: A Historical and Cultural ...KNIL became known as a "foreign legion." While trying to maintain at least a ratio of 1 European to 3 natives (usually Ambonese or Javanese ), the

  3. Neuropsychometric Test in Royal Netherlands Navy Mine-Clearance Divers

    DTIC Science & Technology

    2001-06-01

    1780 CA Den Helder, The Netherlands, tel +31 223 653214, fax +31 223 653148, e -mail ravhulst @wxs.nl 2 TNO Nutrition and Food Research, P.O.Box 360...3700 AJ Zeist, The Netherlands, tel +31 30 694615, fax +31 30 6944422, e -mail emmen@voeding.tno.nl Background: In recent years, there has been growing...Digit Memo Sjan Test (F/B DMST-F/B Learnin /memoie Paper presented at the RTO HFM Symposium on "Operational Medical Issues in Hypo- and Hyperbaric

  4. Meeting Report: Patrick Moore at the Royal Institution

    NASA Astrophysics Data System (ADS)

    Arditti, D.

    2010-02-01

    'Developments in amateur astronomy: past, present and future'. A special meeting in honour of Sir Patrick Moore to celebrate his 75 years as a BAA member, held on 2009 November 21 at the Royal Institution of Great Britain, Albemarle Street, London W1

  5. Humphry Davy and the Royal Institution of Great Britain.

    PubMed

    Unwin, Patrick R; Unwin, Robert W

    2009-03-20

    The abortive attempts of Sir Humphry Davy to introduce modest reforms at the Royal Society of London during his Presidency (1820-27) contrast with his (largely unstudied) earlier experience of administration at the Royal Institution of Great Britain (RI). Davy's attempts to combat the systemic weaknesses in governance and funding, and his role in effecting changes at the RI, in association with a core group of reformers, merit consideration. This paper analyses important aspects of the early management and social structure of the RI and examines the inner workings of the institution. It shows how and why the Library, its most valuable financial asset, and its celebrated Laboratory, developed along distinctive lines, each with its own support structures and intra-institutional interests. While acknowledging the roles traditionally ascribed to Count Rumford and Sir Joseph Banks, the paper highlights the contributions of other early patrons such as Thomas Bernard, son of a colonial governor of Massachusetts, and Earl Spencer, a leading European bibliophile and RI President from 1813 to 1825. The promotion of a Bill in Parliament in 1810, designed to transform the RI from a proprietary body politic into a corporation of members, and the subsequent framing of the bye-laws, provided opportunities to establish a more democratic structure of elected committees for the conduct of science.

  6. Killers in the Brain - Essays in Science and Technology from the Royal Institution

    NASA Astrophysics Data System (ADS)

    Day, Peter

    1999-09-01

    This fascinating and diverse selection of essays from the Royal Institution provides a glimpse of some of the most current and exciting scientific research, ranging from the global increase in asthma and allergies to neurodegenerative diseases known as "brain killers."

  7. Humphry Davy, nitrous oxide, the Pneumatic Institution, and the Royal Institution.

    PubMed

    West, John B

    2014-11-01

    Humphry Davy (1778-1829) has an interesting place in the history of respiratory gases because the Pneumatic Institution in which he did much of his early work signaled the end of an era of discovery. The previous 40 years had seen essentially all of the important respiratory gases described, and the Institution was formed to exploit their possible value in medical treatment. Davy himself is well known for producing nitrous oxide and demonstrating that its inhalation could cause euphoria and heightened imagination. His thinking influenced the poets Samuel Taylor Coleridge and William Wordsworth, and perhaps we can claim that our discipline colored the poetry of the Romantic Movement. Davy was also the first person to measure the residual volume of the lung. The Pneumatic Institution was the brainchild of Thomas Beddoes, who had trained in Edinburgh under Joseph Black, who discovered carbon dioxide. Later Davy moved to the Royal Institution in London formed, in part, to diffuse the knowledge of scientific discoveries to the general public. Davy was a brilliant lecturer and developed an enthusiastic following. In addition he exploited the newly described electric battery to discover several new elements. He also invented the safety lamp in response to a series of devastating explosions in coal mines. Ultimately Davy became president of the Royal Society, a remarkable honor for somebody with such humble origins. Another of his important contributions was to introduce Michael Faraday (1791-1867) to science. Faraday became one of the most illustrious British scientists of all time.

  8. Integrating Social Sustainability in Engineering Education at the KTH Royal Institute of Technology

    ERIC Educational Resources Information Center

    Björnberg, Karin Edvardsson; Skogh, Inga-Britt; Strömberg, Emma

    2015-01-01

    Purpose: The purpose of this paper is to investigate what are perceived to be the main challenges associated with the integration of social sustainability into engineering education at the KTH Royal Institute of Technology, Stockholm. Design/methodology/approach: Semi-structured interviews were conducted with programme leaders and teachers from…

  9. Progress Report of Computerized I&D Services at the Royal Institute of Technology, Stockholm.

    ERIC Educational Resources Information Center

    Tell, Bjorn; Gluchowicz, Zofia

    During the five years of activities the documentation centre at the Royal Institute of Technology has established itself as an information centre in the fields of science and technology. The SDI service is now well implemented and its activities are used and appreciated by scientists, research workers and engineers at the universities, research…

  10. Cosmic Rays - Essays in Science and Technology from the Royal Institution

    NASA Astrophysics Data System (ADS)

    Catlow, Richard; Greenfield, Susan

    2002-04-01

    Since its foundation in 1799, the Royal Institution of Great Britain has inspired enthusiasm and excitement for science, as a means to understanding the world around us. The Friday Evening Discourses were initiated by Michael Faraday in 1826 and are one of the most prestigious series of popular science lectures in the world.This new selection of essays from the Royal Institution offers fascinating and authoritative accounts of current thinking in diverse areas of science, ranging from cosmic rays to the development of new materials that seem to have a life of their own. Also in this collection are essays that consider how scientists can better convey their work to the general public and to a younger generation.

  11. [Health Institutions of the Hungarian and Imperial-Royal Armed Forces in the First World War].

    PubMed

    Kiss, Gábor

    2006-01-01

    The Military Health Institutes established during the World War I. aimed maintenance and recovery of soldiers' fighting value. Establishing an effective sanitary control was rather important, since the Hungarian Royal Honvéd Army attempted to prevent epidemics and diseases, especially venereal diseases and tuberculosis. The sanitary establishments consisted of three parts: they belonged to the operational area, to the provisional zone and to the homeland territory. These institutions were divided into permanent and temporary ones. Permanent sanitary institutions were the garrison hospitals; troop and military ("honvéd") hospitals and houses for invalids, while temporary sanitary establishments worked only in case of mobilization. In their arrangement not the distance was taken into consideration, but the potential for transport of the wounded. The Hungarian sanitary institutions proved to be rather successful in World War I.

  12. The importance of picking Porter: the Royal Institution, George Porter and the two cultures, 1959–64

    PubMed Central

    Cole, Rupert

    2015-01-01

    This paper examines the cultural reasons why in 1964 the Royal Institution (RI) selected George Porter, who became the only person so far to have been Director of the Royal Institution (1966–85), President of the Royal Society (1985–90) and President of the British Association (1985–86) at the same time, to succeed William Lawrence Bragg as the institution's scientific director and resident professor. Porter was established as first choice by an inner group of RI Managers before the formal selection process began. In this article I argue that Porter won their favour by presenting himself, during his tenure as the RI's Professor of Chemistry (1963–66), as a candidate who fitted well with the Managers' ideas about the future role of the RI—ideas that were deeply influenced by the prevailing technocratic visions of ‘science and society’, particularly C. P. Snow's writings on the ‘two cultures’.

  13. Reprint of "Egon Matijević and The Royal Institution" [J. Colloid Interface Sci. 309 (2007) 189-191].

    PubMed

    Thomas, John Meurig

    2007-06-15

    The background to the Faraday Evening Discourse given by Egon Matijević in 1989, as well as its impact, is outlined, and so also is his participation in the special Faraday Discussion convened at the Royal Institution in September, 1991 to mark the bicentennial of Michael Faraday's birth.

  14. Royal Observatory, Edinburgh

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The Royal Observatory, Edinburgh (ROE) comprises the UK Astronomy Technology Centre (ATC) of the PARTICLE PHYSICS AND ASTRONOMY RESEARCH COUNCIL, and the University of Edinburgh's Institute for Astronomy....

  15. "Agricultural Chymistry is at present in it's infancy": The Board of Agriculture, The Royal Institution and Humphry Davy.

    PubMed

    James, Frank A J L

    2015-01-01

    In this paper I sketch the institutional interactions between the Board of Agriculture and the Royal Institution in the late eighteenth and early nineteenth centuries. This includes analysing the composition of memberships and committees of both bodies in which, inter alia, I challenge Morris Berman's account of their institutional relations. A key figure was Humphry Davy who, because of his career ambitions, occupied a slightly uncomfortable position as Professor of Chemistry to both organisations. Davy's lecture notebooks and his subsequent publication Elements of Agricultural Chemistry reveal that he drew almost all his direct knowledge of the subject from Britain and Ireland. Yet, despite such parochial shortcomings that might be expected of an infant science at time of war, the popularity of his book, particularly in North America, provided continuity between the end of the Board of Agriculture in 1822 and the start of the impact of Justus Liebig's work in the 1840s.

  16. Thomas Ferrar, MB, LRCSI (1797-1837): the absentee professor of surgery at the Royal Belfast Academical Institution.

    PubMed Central

    Froggatt, P.

    1996-01-01

    Thomas Ferrar was the second professor of surgery in the short-lived (1835-1849) medical school of the Royal Belfast Academical Institution. Appointed on 5 July 1836 he failed to turn up for the winter session and was accordingly discharged on 29 November. He died in Sligo in the following June aged 39. Nothing has been written about Ferrar who survives as a mere foot-note in Belfast medical history. The events leading to his dismissal are, however, unusual, equivocal, and worth recounting. The facts suggest that the Institution was clearly justified in its action but that Ferrar emerges with some credit for a certain if misplaced high-mindedness though overshadowed by his patent derelictions. Images Figure PMID:8979785

  17. Netherlands Institute of Care and Welfare/NIZW: Source of Knowledge and Inspiration.

    ERIC Educational Resources Information Center

    Netherlands Inst. of Care and Welfare, Utrecht.

    Playing an important role in developing new social policies and introducing new methods, the Netherlands Institute of Care and Welfare (NIZW) is an independent foundation funded by a combination of private and public monies to conduct research and to develop and implement programs in five areas: (1) care and nursing; (2) organization of care; (3)…

  18. Knowledge Transfer between SMEs and Higher Education Institutions: Differences between Universities and Colleges of Higher Education in the Netherlands

    ERIC Educational Resources Information Center

    Delfmann, Heike; Koster, Sierdjan

    2012-01-01

    Knowledge transfer (KT) between higher education institutions (HEIs) and businesses is seen as a key element of innovation in knowledge-driven economies: HEIs generate knowledge that can be adopted in the regional economy. This process of valorization has been studied extensively, mainly with a focus on universities. In the Netherlands, there is a…

  19. Changing Children’s Understanding of the Brain: A Longitudinal Study of the Royal Institution Christmas Lectures as a Measure of Public Engagement

    PubMed Central

    Gjersoe, Nathalia L.; Hood, Bruce

    2013-01-01

    Demonstrating the impact of public engagement is an increasingly important activity for today’s academics and researchers. The difficulty is that many areas of interest do not lend themselves well to evaluation because the impact of each single intervention can be hard to trace and take time to become manifest. With this in mind, we evaluated a lecture based around the 2011 Royal Institution Christmas Lectures, ”Meet Your Brain,” delivered to school children from low performing schools. We compared knowledge about four neuroscience facts one week before, one week after and six weeks after the lecture. Analysis revealed significant knowledge transfer one week after the lecture that was retained five weeks later. We conclude that public engagement through tailored lectures can have significant impact in the moderate term with the potential to leave a lasting impression over a longer period. PMID:24260513

  20. 2D AND 3D dose verification at The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital using EPIDs

    NASA Astrophysics Data System (ADS)

    Mijnheer, Ben; Mans, Anton; Olaciregui-Ruiz, Igor; Sonke, Jan-Jakob; Tielenburg, Rene; Van Herk, Marcel; Vijlbrief, Ron; Stroom, Joep

    2010-11-01

    A review is given of the clinical use of EPID dosimetry in the Department of Radiation Oncology of The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital. All curative plans (almost all IMRT or VMAT) are verified with EPID dosimetry, mostly in vivo. The 2D approach for IMRT verification and the 3D method for VMAT verification are elucidated and their clinical implementation described. It has been shown that EPID dosimetry plays an important role in the total chain of verification procedures that are implemented in our department. It provides a safety net for advanced treatments such as IMRT and VMAT, as well as a full account of the dose delivered.

  1. Thank you, Royal Society

    NASA Astrophysics Data System (ADS)

    Toumey, Chris

    2015-04-01

    More than a decade after it was first published, Chris Toumey revisits a report from the Royal Society on the opportunities and uncertainties of nanotechnology, and finds that it still has plenty to offer.

  2. European Standards for Quality Assurance and Institutional Practices of Student Assessment in the UK, the Netherlands and the Czech Republic

    ERIC Educational Resources Information Center

    Kohoutek, Jan

    2014-01-01

    This article analyses the student assessment procedures of 12 universities in the UK, the Netherlands and the Czech Republic with respect to their alignment with the European standards and guidelines on the quality of assessing higher education students (European Standards and Guidelines for Quality Assurance [ESG] 1.3). Based on qualitative…

  3. Cross-institutional Flood Forecasting in Regional Water Systems;Innovative application of Delft-FEWS in The Netherlands

    NASA Astrophysics Data System (ADS)

    van Heeringen, Klaas-Jan; Douben, Klaas-Jan; van de Wouw, Mark; IJpelaar, Ruben; van Loenen, Arnejan

    2015-04-01

    The regional water system in the North-Brabant province in The Netherlands is (operationally) managed by four different Water Authorities: Rijkswaterstaat Southern-Netherlands, and the three Regional Water Authorities (RWA's) Aa & Maas, De Dommel and Brabantse Delta. The water systems basically consist of mid-sized (navigable) canals, semi-natural brook valleys in mildly sloping sandy soils, and man-made watercourses in clayey polder areas. The management areas of the De Dommel and Brabantse Delta RWA's are bordering Belgium over a total length of approx. 185 km, and are prone to transboundary flood flows. The current project 'Dynamic Water Management' intends to improve the mutual cooperation and communication between the RWA's and Rijkswaterstaat during periods of both high and low water stages. The project deals with governance issues such as water agreements and water systems analyses. A powerful product of the project is a DSS for flood forecasting ('DSS Brabant'). One of the main benefits of cooperation between the RWA's and Rijkswaterstaat is to enable assistance during peak flows and flood events and to try to optimise operational water systems management by deploying drainage and storage facilities by using the connecting (navigable) canals. A set of hydraulic structures like pumps, weirs and sluices facilitate the control and routing of the water flows. Especially during peak flow and flood events, these canals allow to deviate excess flow to neighbours who suffer less from flooding. During regular conditions the water systems are fully independent, but during floods connections are made by using the canal system. The heart of DSS Brabant consists of a Delft-FEWS application, containing several RTC (1st) and hydrodynamic Sobek (2nd order) models FEWS is receiving a variety of data on hourly or six-hourly basis, consisting of measured and forecasted meteorological input (radar-precipitation/HIRLAM, evaporation and wind), water levels and discharges at

  4. Experiences of home and institution in a secured nursing home ward in The Netherlands: A participatory intervention study.

    PubMed

    Klaassens, Mirjam; Meijering, Louise

    2015-08-01

    Nursing homes have been criticised for not providing a home for their residents. This article aims to provide insight into (1) the features of home and institution as experienced by residents and caregivers of a secured ward in a nursing home, and (2) how interventions implemented on the ward can contribute to a more home-like environment. For this purpose, a participatory intervention study, involving both caregivers and residents, was carried out. We collected data through qualitative research methods: observations, in-depth interviews and diaries to evaluate the interventions over time. We adopted an informed grounded theory approach, and used conceptualisations of total institutions and home as a theoretical lens. We found that the studied ward had strong characteristics of a total institution, such as batch living, block treatment and limited privacy. To increase the sense of home, interventions were formulated and implemented by the caregivers to increase the residents' autonomy, control and privacy. In this process, caregivers' perceptions and attitudes towards the provision of care shifted from task-oriented to person-centred care. We conclude that it is possible to increase the home-like character of a secured ward by introducing core values of home by means of interventions involving both caregivers and residents.

  5. [The infirmaries of ladies and servants in the Spanish royal court of the seventeenth century].

    PubMed

    Campos Diez, Soledad

    2002-01-01

    The object of the present institutional study is the help and health care received by ladies and servants of the palace in the Spanish royal court of the 17th century. The study draws on documents recorded under the heading "The Infirmary of Ladies and Servants" in file 447 of the administrative section at the General Records of the Madrid Royal Palace.

  6. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread.

    PubMed

    Weterings, V; Zhou, K; Rossen, J W; van Stenis, D; Thewessen, E; Kluytmans, J; Veenemans, J

    2015-08-01

    We describe an outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-KP) ST258 that occurred in two institutions (a hospital and a nursing home) in the Netherlands between July and December 2013. In total, six patients were found to be positive for KPC-KP. All isolates were resistant to colistin and exhibited reduced susceptibility to gentamicin and tigecycline. In all settings, extensive environmental contamination was found. Whole genome sequencing revealed the presence of bla KPC-2 and bla SHV-12 genes, as well as the close relatedness of patient and environmental isolates. In the hospital setting, one transmission was detected, despite contact precautions. After upgrading to strict isolation, no further spread was found. After the transfer of the index patient to a nursing home in the same region, four further transmissions occurred. The outbreak in the nursing home was controlled by transferring all KPC-KP-positive residents to a separate location outside the nursing home, where a dedicated nursing team cared for patients. This outbreak illustrates that the spread of pan-resistant Enterobacteriaceae can be controlled, but may be difficult, particularly in long-term care facilities. It, therefore, poses a major threat to patient safety. Clear guidelines to control reservoirs in and outside the hospitals are urgently needed.

  7. [Anaphylaxis caused by royal jelly].

    PubMed

    Roger, A; Rubira, N; Nogueiras, C; Guspi, R; Baltasar, M; Cadahia, A

    1995-01-01

    Royal jelly is the food on which are fed and which causes them to develop into queen bees. It is claimed to have rejuvenating virtues for human beings. This report describes a 15-year-old atopic woman who presented, 15 minutes after the intake of royal jelly, local angioedema, generalised urticaria, dysphonia and bronchospasm. She was given antihistaminics and corticoesteroids and responded well. The ingested product contains royal jelly, lactose and potassium sorbate. No anaphylactic reactions to lactose and sorbates have been described previously. Prick test to common food allergens hymenoptera venoms and pollens were negative. RAST to meletin was also negative. Blood eosinophils were 600 and total IgE 465. Non-commercial prepared specific IgE to royal jelly was positive (0.8 KU/l). Prick by prick was positive to 1/10 dilution, being negative in controls (undiluted). No oral provocation test was performed due to the risk of anaphylaxis. No reported cases of royal jelly allergy were founded in a review of the medical literature. Concluding, it is the first described case of IgE anaphylactic reaction due to royal jelly.

  8. Health-Related Fitness in the Royal Netherlands Army

    DTIC Science & Technology

    2009-10-01

    and at low prices. It was concluded that health promotion activities for this target group were beneficial, but only in concordance with a health...actually worry about chronic disease following these practices is often lacking. Therefore, messages for this target group should aim for the

  9. Netherlands Antilles.

    PubMed

    1983-10-01

    This discussion of the Netherlands Antilles focuses on the following: geography, the people, history, government, political conditions, economy, and foreign relations. In 1980 the population totaled 253,400 with an annual growth rate of 1%. The Netherlands Antilles consists of 2 groups of 3 islands each, situated in the Caribbean Sea about 880 kilometers apart. 40 nationalities are represented. Dutch is the official language, but Spanish and English are spoken widely. Alonzo de Ojeda, a Spanish navigator, landed on Curacao in 1499, and in 1527 the Spanish took possession of Curacao, Bonaire, and Aruba. In 1634 the 3 islands passed to the Netherlands, where they have remained except for 2 short periods during the Napoleonic wars when the British ruled at Willemstad. According to the statute of 1954, which serves as the constitution, the Netherlands Antilles has a constitutional and parliamentary form of government. The highest power in the Kingdom of the Netherlands is the sovereign, Queen Beatrix, who is represented in the Antilles by an appointed governor. The independent court system is under the control of the chief justice of the Supreme Court of Justice. Each of the island territories has its own representative body, the Island Council. Politics are dominated by 3 issues: economic problems, the prospect of independence, and Aruban separatism. The economic well-being of the Netherlands Antilles is based principally on the operations of 2 huge oil refineries. Because of the high volume of shipments in and out of the 2 islands, Curacao and Aruba ports are among the busiest in the world. Until recently, petroleum or petroleum products accounted for about 85% of the dollar volume of imports and exports from the Netherlands Antilles. That figure has declined with the worldwide oil glut, and the refineries are using only 50-60% of capacity. The next most important industries are tourism and offshore investment and banking. The per capita income in the Antilles is one

  10. Proteome analysis of Apis mellifera royal jelly.

    PubMed

    Schönleben, Simone; Sickmann, Albert; Mueller, Martin J; Reinders, Joerg

    2007-10-01

    Royal jelly plays a pivotal role in the development of honey bee larvae. However, while various health promoting properties of royal jelly have been reported, most of the active substances within royal jelly that lead to these properties are still unknown. Since up to 50% (dry mass) of royal jelly is protein, royal jelly proteome analysis is a promising starting point for attempts to identify the proteins that provide health-promoting effects. However, the comprehensive analysis of royal jelly proteins is hampered by the enormous abundance of some proteins in the major royal jelly protein family, which constitutes 80-90% of the royal jelly proteome. The high heterogeneity of these proteins is an additional challenge for proteomic analysis, since it necessitates the use of analytical techniques that provide high resolution and a wide dynamic range. The application of individual methods such as 2D-PAGE or multidimensional chromatography can only yield certain subpopulations of a proteome due to the specific bias of each method. We applied different methods for the prefractionation and separation of royal jelly proteins in order to circumvent the shortcomings of the individual techniques and achieve a high coverage of the royal jelly proteome. In this way, we were able to identify 20 different proteins in total, as well as to show a very high degree of cleavage of different proteins of the major royal jelly protein family. Furthermore, we investigated the protein phosphorylation of royal jelly proteins, and identified and located two phosphorylation sites within venom protein 2.

  11. The Netherlands.

    ERIC Educational Resources Information Center

    Oomen, Annemarie; de Vos, J. A. M.

    The labor market in the Netherlands is characterized by rapid economic and technological development. In response to this, a new approach to career development has been to expand individuals' career competencies. Education, employment policy, non-profit organizations, and corporate life are facing the task of developing career development services…

  12. Reviews Book: Voyage to the Heart of the Matter: The ATLAS Experiment at CERN Equipment: SEP Spectroscope Books: Quantum Gods / The Universe Places to visit: The Royal Institution of Great Britain Book: What is this Thing Called Science? Book: Don't be Such a Scientist: Talking Substance in the Age of Style Equipment: La Crosse Anemometer Book: Wonder and Delight Web Watch

    NASA Astrophysics Data System (ADS)

    2010-05-01

    WE RECOMMEND SEP Spectroscope Flatpacked classroom equipment for pupils aged 10 and over Quantum Gods Book attacks spiritualism and religion with physics The Universe Study of whether physics alone can explain origin of universe La Crosse Anemometer Handheld monitor is packed with useful features Wonder and Delight Essays in science education in honour of Eric Rogers WORTH A LOOK Voyage to the Heart of the Matter: The ATLAS Experiment at CERN Pop-up book explains background to complex physics The Royal Institution of Great Britain RI museum proves interesting but not ideal for teaching What is this Thing Called Science? Theory and history of science in an opinionated study Don't be Such a Scientist: Talking Substance in the Age of Style Explanation of how science is best communicated to the public WEB WATCH Particle physics simulations vary in complexity, usefulness and how well they work

  13. [The insigne and suntuoso Royal Hospital of Granada (I). Royal foundations and the hospital regrouping (1501-1526)].

    PubMed

    Valenzuela Candelario, José

    2003-01-01

    In the 1520s the local authorities planned to set up a new modern hospital in the city of Granada by combining two existing Royal Hospitals: Alhambra and Reyes. As a public institution and as a new building, the new hospital could develop the mandates of the original foundation and extend its care to become a general hospital. In this way it would strengthen its status as a charitable undertaking and legacy of the Catholic Monarchs and, secondly, as a great architectural monument.

  14. First-year evaluation of IMERG - Final Run in the Netherlands

    NASA Astrophysics Data System (ADS)

    Rios Gaona, Manuel Felipe; Overeem, Aart; Leijnse, Hidde; Uijlenhoet, Remko

    2016-04-01

    For almost two years now, the Global Precipitation Measurement (GPM) mission has provided worldwide satellite rainfall estimates at higher spatiotemporal resolutions than its predecessor TRMM (Tropical Rainfall Measurement Mission). Accurate rainfall estimates at higher resolutions are the main input in modeling physical processes relevant to society like floods, landslides, and weather extremes. Conversely to TRMM Multi-satellite Precipitation Analysis (TMPA) products, the Netherlands is within the coverage of GPM Level-3 products, i.e., IMERG (Integrated Multi-satellite Retrievals for GPM). The IMERG spatiotemporal resolution is 0.1° x 0.1° every 30 min (180°W to 180°E, and 60°N to 60°S), with latencies of 6, 18 hours and 4 months. Here we evaluate the first full year of the IMERG Day 1 Final Run over the land surface of the Netherlands. IMERG Final Run is considered the research product, and provides the longest public data set among IMERG products. We compare half-hourly and daily IMERG rainfall maps against Dutch gauge-adjusted radar rainfall maps. Radar rainfall maps are provided by the Royal Netherlands Meteorological Institute (KNMI), and are considered as the ground truth given its accuracy, spatiotemporal resolution and availability. In general, there is a tendency of GPM to underestimate rainfall intensities over the land surface of the Netherlands. Nevertheless, this underestimation is relatively low, which suggests a potential applicability of IMERG Final Run as a reliable source of rainfall estimates in diverse hydrological and hydrometeorological applications. The robustness and data availability of IMERG is an important asset, especially in places where rain gauge networks are scarce or poorly maintained, or where weather radar networks are too expensive to acquire and/or maintain.

  15. Lessons from the United Kingdom's Royal Society

    ERIC Educational Resources Information Center

    Allen, Henry Lee

    2010-01-01

    Celebrating its 350th anniversary as a scholarly association devoted to scientific pursuits, the Royal Society (UK), in March 2010, published "The Scientific Century: Securing Our Future Prosperity." In its report, the Royal Society argues against both the notion of withdrawing public investment from its world-class universities and the…

  16. Persistent Identifiers for Dutch cultural heritage institutions

    NASA Astrophysics Data System (ADS)

    Ras, Marcel; Kruithof, Gijsbert

    2016-04-01

    Over the past years, more and more collections belonging to archives, libraries, media, museums, and knowledge institutes are being digitised and made available online. These are exciting times for ALM institutions. They are realising that, in the information society, their collections are goldmines. Unfortunately most heritage institutions in the Netherlands do not yet meet the basic preconditions for long-term availability of their collections. The digital objects often have no long lasting fixed reference yet. URL's and web addresses change. Some digital objects that were referenced in Europeana and other portals can no longer be found. References in scientific articles have a very short life span, which is damaging for scholarly research. In 2015, the Dutch Digital Heritage Network (NDE) has started a two-year work program to co-ordinate existing initiatives in order to improve the (long-term) accessibility of the Dutch digital heritage for a wide range of users, anytime, anyplace. The Digital Heritage Network is a partnership established on the initiative of the Ministry of Education, Culture and Science. The members of the NDE are large, national institutions that strive to professionally preserve and manage digital data, e.g. the National Library, The Netherlands Institute for Sound and Vision, the Netherlands Cultural Heritage Agency, the Royal Netherlands Academy of Arts and Sciences, the National Archive of the Netherlands and the DEN Foundation, and a growing number of associations and individuals both within and outside the heritage sector. By means of three work programmes the goals of the Network should be accomplished and improve the visibility, the usability and the sustainability of digital heritage. Each programme contains of a set of projects. Within the sustainability program a project on creating a model for persistent identifiers is taking place. The main goals of the project are (1) raise awareness among cultural heritage institutions on the

  17. The influence of temperature and climate change on the timing of pollen release in the Netherlands

    NASA Astrophysics Data System (ADS)

    van Vliet, Arnold J. H.; Overeem, Aart; de Groot, Rudolf S.; Jacobs, Adrie F. G.; Spieksma, Frits T. M.

    2002-11-01

    In the last decade it has become clear that the timing of many phenological processes, like the start of flowering and leaf unfolding in spring, have changed. The increase in temperature is believed to be the main cause. The earlier start of flowering will have consequences for the start of the pollen season, and thus for the start of the hay fever season. Millions of people world-wide will therefore experience the impact of climate change in their daily lives during spring and summer. In this paper we analyse the relation between climate parameters, especially temperature, and the start of the pollen season in the western part of the Netherlands based on daily pollen counts of the Leiden University Medical Centre and temperature measurements from 1969 till 2000 by the Royal Netherlands Meteorological Institute in De Bilt. The results indicate that there is a strong correlation between temperature and start of the pollen season. An advance of the start of the pollen season of 3 to 22 days has been observed. The potential future changes in the start of the pollen season under climate change scenarios are also discussed.

  18. Multi-Dimensional Impact of the Public-Private Center for Translational Molecular Medicine (CTMM) in the Netherlands: Understanding New 21(st) Century Institutional Designs to Support Innovation-in-Society.

    PubMed

    Steuten, Lotte M

    2016-05-01

    Knowledge translation is at the epicenter of 21st century life sciences and integrative biology. Several innovative institutional designs have been formulated to cultivate knowledge translation. One of these organizational innovations has been the Center for Translational Molecular Medicine (CTMM), a multi-million public-private partnership in the Netherlands. The CTMM aims to accelerate molecular diagnostics and imaging technologies to forecast disease susceptibilities in healthy populations and early diagnosis and personalized treatment of patients. This research evaluated CTMM's impact on scientific, translational, clinical, and economic dimensions. A pragmatic, operationally-defined process indicators approach was used. Data were gathered from CTMM administrations, through a CTMM-wide survey (n = 167) and group interviews. We found that the CTMM focused on disease areas with high human, clinical, and economic burden to society (i.e., oncology, cardiovascular, neurologic, infection, and immunity diseases). CTMM displayed a robust scientific impact that rests 15%-80% above international reference values regarding publication volume and impact. Technology translation to the clinic was accelerated, with >50% of projects progressing from pre-clinical development to clinical testing within 5 years. Furthermore, CTMM has generated nearly 1500 Full Time Equivalent (FTE) of translational R&D capacity. Its positive impact on translational, (future) clinical, and economic aspects is recognized across all surveyed stakeholders. As organizational innovation is increasingly considered critical to forge linkages between life sciences discoveries and innovation-in-society, lessons learned from this study may inform other institutions with similar objectives such as the Clinical and Translational Science Awards (CTSA) Program of the National Institutes of Health (NIH) in the United States.

  19. [The intervention of the Royal College of Medicine in Nancy in the regulation of pharmaceutical activity].

    PubMed

    Labrude, Pierre

    2011-01-01

    Created in 1752 the Royal College of Medicine in Nancy constituted an institution with extended powers, particularly in sanitary policy and pharmaceutical activity. After explaining the rules of the College, the paper describes with examples its participation to the examinations of pharmacy pupils and their sustaining of "Conclusions de pharmacie et de chymie", to the delivery of drugs and to the fight against charlatanry and prohibited activity of pharmacy. From its creating to its disparition in 1793 by order of the government, the Royal College of Medicine worked remarkably, and the rules worked up during the forty years of its life appear to be of a great modernity.

  20. netherland hydrological modeling instrument

    NASA Astrophysics Data System (ADS)

    Hoogewoud, J. C.; de Lange, W. J.; Veldhuizen, A.; Prinsen, G.

    2012-04-01

    Netherlands Hydrological Modeling Instrument A decision support system for water basin management. J.C. Hoogewoud , W.J. de Lange ,A. Veldhuizen , G. Prinsen , The Netherlands Hydrological modeling Instrument (NHI) is the center point of a framework of models, to coherently model the hydrological system and the multitude of functions it supports. Dutch hydrological institutes Deltares, Alterra, Netherlands Environmental Assessment Agency, RWS Waterdienst, STOWA and Vewin are cooperating in enhancing the NHI for adequate decision support. The instrument is used by three different ministries involved in national water policy matters, for instance the WFD, drought management, manure policy and climate change issues. The basis of the modeling instrument is a state-of-the-art on-line coupling of the groundwater system (MODFLOW), the unsaturated zone (metaSWAP) and the surface water system (MOZART-DM). It brings together hydro(geo)logical processes from the column to the basin scale, ranging from 250x250m plots to the river Rhine and includes salt water flow. The NHI is validated with an eight year run (1998-2006) with dry and wet periods. For this run different parts of the hydrology have been compared with measurements. For instance, water demands in dry periods (e.g. for irrigation), discharges at outlets, groundwater levels and evaporation. A validation alone is not enough to get support from stakeholders. Involvement from stakeholders in the modeling process is needed. There fore to gain sufficient support and trust in the instrument on different (policy) levels a couple of actions have been taken: 1. a transparent evaluation of modeling-results has been set up 2. an extensive program is running to cooperate with regional waterboards and suppliers of drinking water in improving the NHI 3. sharing (hydrological) data via newly setup Modeling Database for local and national models 4. Enhancing the NHI with "local" information. The NHI is and has been used for many

  1. The first President of the Royal Society.

    PubMed

    Fara, Patricia

    2003-12-01

    Few people know the name of the Royal Society's first President, even though he features prominently in Thomas Sprat's famous allegorical frontispiece. In promotional images, his individual identity is irrelevant for proclaiming the Society's allegiance to Francis Bacon and commitment to experimental investigation. By contrast, William Brouncker's name does appear on Peter Lely's large portrait, which hung at the Royal Society. Brouncker was a gifted mathematician as well as a conscientious administrator, and Lely's portrait reproduces the diagram of one of his innovative algebraic proofs.

  2. Going Dutch: Higher Education in the Netherlands

    ERIC Educational Resources Information Center

    Law, David

    2016-01-01

    This article outlines some of the policy issues currently faced by research-based universities in the Netherlands. The focus is on four leading universities (University of Amsterdam: UvA; Free University of Amsterdam: VU; Leiden University; and Delft University of Technology: TUD). The author visited these institutions as part of a Study Tour…

  3. Time Resolved Resonance Raman Conference Royal Institution, London United Kingdom,

    DTIC Science & Technology

    1983-01-01

    of several polyenes were discussed in detail with the emphases on the detection and understanding of molecular transformation especially cis-trans...bacteriorhodopsin are closesly connected with the polyenes since the bacteriorhodopsin chro-ophose consists of a protonated shift base polyene . It is of interest to

  4. 1. Historic American Buildings Survey Royal Insurance Co. Booklet '75 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Royal Insurance Co. Booklet '75 Royal Years', 1928 PHOTO TAKEN 1850's - Sacramento Block, Historic View, Sacramento Street & Battery Street, San Francisco, San Francisco County, CA

  5. [Royal jelly: component efficiency, analysis, and standardisation].

    PubMed

    Oršolić, Nada

    2013-09-01

    Royal jelly is a viscous substance secreted by the hypopharyngeal and mandibular glands of worker honeybees (Apis mellifera) that contains a considerable amount of proteins, free amino acids, lipids, vitamins, sugars, and bioactive substances such as 10-hydroxy-trans-2-decenoic acid, antibacterial protein, and 350-kDa protein. These properties make it an attractive ingredient in various types of healthy foods. This article brings a brief review of the molecular mechanisms involved in the development of certain disorders that can be remedied by royal jelly, based on a selection of in vivo and in vitro studies. It also describes current understanding of the mechanisms and beneficial effects by which royal jelly helps to combat aging-related complications. Royal jelly has been reported to exhibit beneficial physiological and pharmacological effects in mammals, including vasodilative and hypotensive activities, antihypercholesterolemic activity, and antitumor activity. As its composition varies significantly (for both fresh and dehydrated samples), the article brings a few recommendations for defining new quality standards.

  6. A suggestion for royal jelly specifications.

    PubMed

    Kanelis, Dimitrios; Tananaki, Chrysoula; Liolios, Vasilis; Dimou, Maria; Goras, Georgios; Rodopoulou, Maria Anna; Karazafiris, Emmanuel; Thrasyvoulou, Andreas

    2015-12-01

    This article proposes guidelines for quality standards of royal jelly. The proposals are based on two sets of data; the first from our study of the factors that may affect the royal jelly's chemical composition (protein and sugar supplementation of beehives) and the second on the analysis of a great number of samples from across Greece to establish natural variability of this product. We compared our findings with the adopted national limits, the proposals of the working group of the International Honey Commission (IHC), and the draft proposal of the International Organization of Standardization (ISO). The studied parameters included moisture, total proteins, sugars (fructose, glucose, sucrose, total sugars), and 10-hydroxy- 2-decenoic acid (10-HDA). Our results indicate that the limits for royal jelly in some countries should be amended and the proposals of the IHC and the ISO reviewed in view of recent data on variability. We believe that our proposals could be considered for setting global standards for royal jelly, as they incorporate national legislations, proposals of scientific groups, experimental data, and updated information.

  7. Royal Naval nursing: 'testing but worth it'.

    PubMed

    Moore, Alison

    2014-08-19

    Inga Kennedy is the most senior nurse in the Royal Navy. She enjoys the commitment and discipline required by a career in the armed forces and says the work offers great opportunities for nurses. Her career highlights have included checking that injured personnel in Afghanistan were receiving the best care possible.

  8. Margaret Cavendish and the Royal Society

    PubMed Central

    Wilkins, Emma

    2014-01-01

    It is often claimed that Margaret Cavendish was an anti-experimentalist who was deeply hostile to the activities of the early Royal Society—particularly in relation to Robert Hooke's experiments with microscopes. Some scholars have argued that her views were odd or even childish, while others have claimed that they were shaped by her gender-based status as a scientific ‘outsider’. In this paper I examine Cavendish's views in contemporary context, arguing that her relationship with the Royal Society was more nuanced than previous accounts have suggested. This contextualized approach reveals two points: first, that Cavendish's views were not isolated or odd when compared with those of her contemporaries, and second, that the early Royal Society was less intellectually homogeneous than is sometimes thought. I also show that, although hostile to some aspects of experimentalism, Cavendish nevertheless shared many of the Royal Society's ambitions for natural philosophy, especially in relation to its usefulness and the importance of plain language as a means to disseminate new ideas. PMID:25254278

  9. [A tale of 2 cities. The dispute over the true origins of the Royal Society].

    PubMed

    Beeley, Philip

    2008-01-01

    When the Royal Society was founded in November 1660 it took scientific societies already existing in other European countries as its model. However, at a time when the new mathematical and experimental sciences were still generally without a secure institutional foundation there was also great interest in the new society on the part of scientists and scholars abroad. Soon visitors such as Christiaan Huygens and Balthazar de Monconys were able to report positively on its practical orientation, while among others Johannes Hevelius and Philipp Jacob Sachs von Lewenhaimb in letters to the founder member John Wallis and to the secretary Henry Oldenburg requested more information on its origins and statutes. Meanwhile, in England the Royal Society found itself the object of vociferous criticism, especially from the universities, which saw their own role as centres of learning increasingly compromised by the existence of an institution dedicated to the promotion of modern science. The Royal Society responded to this interest from abroad and criticism at home by commissioning an official history written by Thomas Sprat, a man with a university as well as a literary background. However, despite the author's good credentials, the History of the Royal Society presents a one-sided account of the institution, mainly from the perspective of the circle around John Wilkins to which Sprat had belonged. According to their point of view the Royal Society arose from meetings which Wilkins had organized at Wadham College in Oxford in the early 1650s. For members of the old guard, such as Wallis and William Brouncker, the origins of the Royal Society were, however, not in Oxford but rather in London, where meetings involving a significant number of members of the future institution had taken place already in the mid-1640s. This was not simply a question of historical accuracy, but also of the way in which the Royal Society conceived itself: while the circle around Wilkins was in

  10. Case of anaphylaxis caused by ingestion of royal jelly.

    PubMed

    Katayama, Mirei; Aoki, Mikako; Kawana, Seiji

    2008-04-01

    Anaphylaxis is a severe form of allergic disease. Royal jelly is widely consumed in Japan, but a few cases of anaphylaxis caused by royal jelly have been reported. We encountered a 26-year-old Japanese woman who developed anaphylaxis after drinking a beverage of crude royal jelly including honey. She had a history of bronchial asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis and food allergy (abalone). Prick tests were performed with the beverage of crude royal jelly including honey and with two other beverages including honey. Only the crude royal jelly beverage showed a positive reaction. An oral challenge test with the crude royal jelly beverage was not performed, but a similar test with a beverage including honey caused no symptoms. A positive response to the beverage of crude royal jelly was not observed in normal volunteers. A positive diagnosis of anaphylaxis due to royal jelly was made based on the positive prick test, systemic clinical symptoms and the negative prick tests in healthy volunteers. Moreover, the patient had no symptoms when taking lemon and orange, which were present as essences in the crude royal jelly beverage, and also had no response to honey after anaphylaxis. Increased consumption of royal jelly in health food supplements may increase the incidence of royal jelly-related allergic reactions. Therefore, royal jelly should be considered as a causative allergen in food-induced anaphylaxis.

  11. Biomass in the Netherlands

    SciTech Connect

    Kwant, K.W. Jr.; Smakman, G.J.J.; Nillesen, F.H.G.

    1995-11-01

    The energy production from waste and biomass is one of the most promising methods of exploiting renewable energy in the Netherlands. The position of Dutch industry can be improved by means of technological development. An action plan for energy from waste and biomass will be implemented to double the energy output from the present 26 PJ to 54 PJ in 2000. Actions focus on targeted Research and Development with industry and market introduction with the energy production and distribution sector. The government will impose an energy tax (20%) on electricity and natural gas for households. Being a densely populated country the biomass resources originate mainly from waste and residue streams, while as a condition for conversion processes strict environmental regulations have to be met. Landfill gas is widely extracted and converted into energy. Part of the organic fraction of MSW is source separated, digested and upgraded to natural gas quality, while the digestate is used as compost. New development are in the area of cocombustion of wastewood in coal fired power stations. The first plant is under construction. A major R&D programme is set up with industry and research institutes on gasification of residues and biomass. At laboratory and pilotplant scale gasification experiments will be carried out with the different available streams. The major effect will be devoted to blending streams and gas cleaning.

  12. 76 FR 80433 - In the Matter of Royal Oak Capital Management, LLC, 6173 Bellevue Road, Royal Oak, MD 21662...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... of 1940 Release No. 3340] In the Matter of Royal Oak Capital Management, LLC, 6173 Bellevue Road, Royal Oak, MD 21662; Notice of Intention To Cancel Registration Pursuant to Section 203(H) of the... Advisers Act of 1940 (the ``Act''), cancelling the registration of Royal Oak Capital Management,...

  13. Henry Oldenburg - Shaping the Royal Society

    NASA Astrophysics Data System (ADS)

    Boas Hall, Marie

    2002-03-01

    Henry Oldenburg, born in 1619 in Bremen, Germany, first came to England as a diplomat on a mission to see Oliver Cromwell. He stayed on in England and in 1662 became the Secretary of the Royal Society, and its best known member to the entire learned world of his time. Through his extensive correspondence, now published, he disseminated the Society's ideals and methods at home and abroad. He fostered and encouraged the talents of many scientists later to be far more famous than he, including Newton, Flamsteed, Malpighi, and Leeuwenhoek with whom, as with many others, he developed real friendship. He founded and edited the Philosophical Transactions, the world's oldest scientific journal.His career sheds new light on the intellectual world of his time, especially its scientific aspects, and on the development of the Royal Society; his private life expands our knowledge of social mobility, the urban society, and the religious views of his time.

  14. The Royal Navy and British Security Policy.

    DTIC Science & Technology

    1983-12-01

    SCHOOL December 1983 Author Approved by: Tesis Avisor s" econd R e r Chafrman, Department of National Security Affairs -- and Policy Sciences " Dean of...8217s based on the 14 VULCAN , VICTOR and VALIANT bombers. Although cooperation with the American SAC was envisioned from the begining, the force did...British strategic nuclear deterrent. This responsibility was once the domain of the Royal Air Force and its VULCAN , VICTOR, and VALIANT bombers, but after

  15. Birds of Isle Royale in Lake Superior

    USGS Publications Warehouse

    Krefting, L.W.; Lee, F.B.; Shelton, P.C.; Gilbert, K.T.

    1966-01-01

    This report constitutes an annotated list of 197 species of birds reported from Isle Royale National Park, a 210-square-mile archipelago in northwestern Lake Superior including some 200 islets and rock outcrops. The island is 45 miles long and 8 miles wide at its widest point. Bird distribution and habitats are described, along with geography and vegetation; 62 species are known to have bred at least once, 26 are thought to be breeders, and the rest are migrants.

  16. Inca Royal Estates in the Sacred Valley

    NASA Astrophysics Data System (ADS)

    McKim Malville, J.

    The royal estates lying between Cusco and Machu Picchu illustrate the remarkable variety by which the sun was honored and worshipped in the Inca Empire. The terraced basins of Moray combine the sun at both solstices and, perhaps, the zenith sun, with flowing water and offerings to Pachamama. The complex astronomy at Urubamba involves the palace of Quespiwanka, horizon pillars, solstices, and mountain worship. Ollantaytambo contains horizontal shadow-casting gnomons with a major water shrine.

  17. Characterization of major allergens of royal jelly Apis mellifera.

    PubMed

    Rosmilah, M; Shahnaz, M; Patel, G; Lock, J; Rahman, D; Masita, A; Noormalin, A

    2008-12-01

    Royal jelly is widely consumed in the community and has perceived benefits ranging from promoting growth in children and improvement of general health status to enhancement of longevity for the elderly. However, royal jelly consumption has been linked to contact dermatitis, acute asthma, anaphylaxis and death. High prevalence of positive skin tests to royal jelly have been reported among atopic populations in countries with a high rate of royal jelly consumption. The present study is aimed to identify the major allergens of royal jelly. Royal jelly extract was separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE) and 2-dimensional electrophoresis (2-D). Immunoblotting of the SDS-PAGE and 2-D profiles were performed to identify the allergenic spots. Spots were then excised from the 2-D gel, digested with trypsin and analyzed by mass spectrometry. The SDS-PAGE of royal jelly extract revealed 18 bands between 10 to 167 kD. Western blot of the fractionated proteins detected 15 IgE-binding bands between 14 to 127 kD with seven major allergens of 32, 40, 42, 49, 55, 60 and 67 kD using serum from 53 subjects with royal jelly allergy. The 2-D gel fractionated the royal jelly proteins to more than 50 different protein spots. Out of these, 30 spots demonstrated specific IgE affinity to the sera tested. Eight spots of the major royal jelly allergens were selected for mass-spectrometry analysis. Digested tryptic peptides of the spots were compared to the amino acid sequence search in protein databases which identified the fragments of royal jelly homologus to major royal jelly protein 1 (MRJ1) and major royal jelly protein 2 (MRJ2). In conclusion, the major allergens of royal jelly are MRJ1 and MRJ2 in our patients' population.

  18. Friend Not Foe: The Role of Curriculum Committee in Supporting the Development of Curriculum at Royal Roads University

    ERIC Educational Resources Information Center

    Young, Michael G.

    2015-01-01

    Curriculum Committee at Royal Roads University (RRU) is mandated with ensuring that program and course curricula are of sufficient high academic integrity, consistent with other academic institutions, delivered in a manner consistent with program outcomes, and align with the recently adopted Learning and Teaching Model. Yet, the apparent…

  19. Royal jelly counteracts bucks' "summer infertility".

    PubMed

    Elnagar, Samar A

    2010-08-01

    Exposure of male rabbits to heat stress during summer adversely affects their fertility leading to major production losses. A total number of 24 male rabbits were randomly divided into four experimental groups exposed to temperatures ranging from a high of 32 degrees C to a low of 23 degrees C. Animals of the 2nd, 3rd and 4th group were individually orally given 200, 400, or 800 mg royal jelly (RJ)/kg body weight once a week to evaluate the ability of RJ feeding to counteract "summer infertility" in bucks and enhance their physiological status. Royal jelly treatments significantly boosted testosterone level to 133, 143 and 124% of basal, increased ejaculated volume by 36, 31 and 18%, increased seminal plasma fructose to 122, 124, and 111%, improved sperm motility by 15, 18 and 5%, increase sperm total output by 65, 63 and 35%, reduced abnormal sperm by 24, 24 and 15% and dead sperm by 27, 25 and 17% compared to the heat stressed control animals. Serum total protein, albumin and globulin increased while serum total lipids, cholesterol and triglycerides decreased with RJ treatments. Creatinine was reduced by 5, 13 and 8% and uric acid by 4, 7 and 4%, respectively for the three doses of RJ compared to control. Alkaline phosphatase has significantly increased to reach 114, 118, and 108% of heat stressed level with the three doses of RJ, indicating the occurrence of active bone deposition. Glucose level increased significantly to reach 105, 112, and 116% of heat stressed control and both calcium and phosphorus increased significantly with RJ treatments. It was concluded that royal jelly administration to heat stressed male rabbits can counteract their "summer infertility" and improve their physiological status.

  20. Rare royal families in honeybees, Apis mellifera

    NASA Astrophysics Data System (ADS)

    Moritz, Robin F. A.; Lattorff, H. Michael G.; Neumann, Peter; Kraus, F. Bernhard; Radloff, Sarah E.; Hepburn, H. Randall

    2005-10-01

    The queen is the dominant female in the honeybee colony, Apis mellifera, and controls reproduction. Queen larvae are selected by the workers and are fed a special diet (royal jelly), which determines caste. Because queens mate with many males a large number of subfamilies coexist in the colony. As a consequence, there is a considerable potential for conflict among the subfamilies over queen rearing. Here we show that honeybee queens are not reared at random but are preferentially reared from rare “royal” subfamilies, which have extremely low frequencies in the colony's worker force but a high frequency in the queens reared.

  1. Oral allergy syndrome in a child provoked by royal jelly.

    PubMed

    Paola, Fantini; Pantalea, Delle Donne; Gianfranco, Calogiuri; Antonio, Ferrannini; Angelo, Vacca; Eustachio, Nettis; Elisabetta, Di Leo

    2014-01-01

    Royal jelly has been demonstrated to have several physiological activities. However, in the literature, different reactions induced by royal jelly are reported. We describe a case of seven-year-old child that was referred to our observation for two episodes of oral allergy syndrome (OAS) that appeared ten minutes after ingestion of royal jelly. Skin prick test with standard panel of inhalant and food allergens, a prick-to-prick test using the royal jelly's extract responsible for patient's reactions, and royal jelly patch test with extemporaneous preparation were performed. The specific IgE by ImmunoCAP System method versus Hymenoptera venom, inhalant allergens, food allergens, and lipid transfer proteins was dosed. According to the positive reactions to royal jelly both by prick-by-prick test and by a first reading patch test, royal jelly immediate hypersensitivity was diagnosed. According to the positive response for almond in both in vivo and in vitro tests we can think of the royal jelly contamination with almond pollen as possible cause of patient's reaction. Moreover, from the results of specific IgE titers versus Compositae pollens, we have argued the possibility that this case of royal jelly allergy could be explained also by the mechanism of cross-reaction with Compositae pollens.

  2. Oral Allergy Syndrome in a Child Provoked by Royal Jelly

    PubMed Central

    Paola, Fantini; Pantalea, Delle Donne; Gianfranco, Calogiuri; Antonio, Ferrannini; Angelo, Vacca; Eustachio, Nettis; Elisabetta, Di Leo

    2014-01-01

    Royal jelly has been demonstrated to have several physiological activities. However, in the literature, different reactions induced by royal jelly are reported. We describe a case of seven-year-old child that was referred to our observation for two episodes of oral allergy syndrome (OAS) that appeared ten minutes after ingestion of royal jelly. Skin prick test with standard panel of inhalant and food allergens, a prick-to-prick test using the royal jelly's extract responsible for patient's reactions, and royal jelly patch test with extemporaneous preparation were performed. The specific IgE by ImmunoCAP System method versus Hymenoptera venom, inhalant allergens, food allergens, and lipid transfer proteins was dosed. According to the positive reactions to royal jelly both by prick-by-prick test and by a first reading patch test, royal jelly immediate hypersensitivity was diagnosed. According to the positive response for almond in both in vivo and in vitro tests we can think of the royal jelly contamination with almond pollen as possible cause of patient's reaction. Moreover, from the results of specific IgE titers versus Compositae pollens, we have argued the possibility that this case of royal jelly allergy could be explained also by the mechanism of cross-reaction with Compositae pollens. PMID:24799914

  3. Quantification of major royal jelly protein 1 in fresh royal jelly by indirect enzyme-linked immunosorbent assay.

    PubMed

    Yamaguchi, Kikuji; He, Shaoyu; Li, Zhengyue; Murata, Kiyoshi; Hitomi, Nobuyuki; Mozumi, Manaho; Ariga, Risa; Enomoto, Toshiki

    2013-01-01

    Rabbit polyclonal antibody produced by a major royal jelly protein 1 (MRJP1) specific peptide reacted only with a MRJP1. Indirect ELISA with the antibody revealed a MRJP1 level of 4.12-4.67 g/100 g in different company's royal jelly, which almost agreed with that of a hexametric form of MRJP1 (apisin) measured by high performance liquid chromatography. These results suggest that MRJP1 exists mainly as apisin in royal jelly.

  4. Psychotraumatology in the Netherlands

    PubMed Central

    Vermetten, Eric; Olff, Miranda

    2013-01-01

    The contribution to psychotrauma literature from Dutch authors has a long tradition. The relatively high lifetime prevalence of trauma and posttraumatic stress disorder (PTSD) is not unique for the Netherlands and does not fully explain the interest in trauma and its consequences. In this overview of psychotraumatology in the Netherlands, we will discuss some of the key events and processes that contribute to the current interest. We outlined the historical basis and development of the field in the Netherlands, including the impact of World War II, the effects of major man-made or natural disasters, engagement in military conflicts, as well as smaller scale traumatic events like sexual abuse and traffic accidents. The liberal and open culture may have reduced stigma to trauma, while other sociocultural aspects may have contributed to increased prevalence. Finally, we describe Dutch psychotraumatology today and how history and culture have shaped the current scientific basis. PMID:23671764

  5. 1. VIEW SHOWING FOUNDATIONS OF HOISTING WORKS, ROYAL MINE, 1988, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW SHOWING FOUNDATIONS OF HOISTING WORKS, ROYAL MINE, 1988, LOOKING SOUTHEAST. GLORY HOLE DROPS OFF TO LEFT, AND EXCAVATED TRENCH FOR THE 1920s SURFACE TRAM IN RIGHT FOREGROUND - Royal Consolidated Gold Mine & Mills, Hoisting Work, 4.0 Air Miles Northwest of Copperopolis, Copperopolis, Calaveras County, CA

  6. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a)...

  7. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a)...

  8. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a)...

  9. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a)...

  10. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a)...

  11. The case for watchful waiting with Isle Royale's wolf population

    USGS Publications Warehouse

    Mech, L. David

    2013-01-01

    In "Should Isle Royale Wolves be Reintroduced? A Case Study on Wilderness Management in a Changing World," Vucetich et al. concluded with the hope that their analysis “motivates broader discussion that deepens understanding of the specifics on Isle Royale and the underlying principles” (2012: 137). This article represents an attempt to continue that discussion.

  12. Genotype analysis identifies the cause of the "royal disease".

    PubMed

    Rogaev, Evgeny I; Grigorenko, Anastasia P; Faskhutdinova, Gulnaz; Kittler, Ellen L W; Moliaka, Yuri K

    2009-11-06

    The "royal disease," a blood disorder transmitted from Queen Victoria to European royal families, is a striking example of X-linked recessive inheritance. Although the disease is widely recognized to be a form of the blood clotting disorder hemophilia, its molecular basis has never been identified, and the royal disease is now likely extinct. We identified the likely disease-causing mutation by applying genomic methodologies (multiplex target amplification and massively parallel sequencing) to historical specimens from the Romanov branch of the royal family. The mutation occurs in F9, a gene on the X chromosome that encodes blood coagulation factor IX, and is predicted to alter RNA splicing and to lead to production of a truncated form of factor IX. Thus, the royal disease is the severe form of hemophilia, also known as hemophilia B or Christmas disease.

  13. Media in the Netherlands.

    ERIC Educational Resources Information Center

    Klaver, Franca

    This 2-part report summarizes Dutch policy on mass media and reviews the status of cable television in the Netherlands. The first part defines the underlying principles of a national policy on mass media in relation to the press, commercial and educational television broadcasting, radio, cable television, and media research. Parliamentary debate…

  14. NCI at Frederick Receives a Royal Visit | Poster

    Cancer.gov

    The Center for Cancer Research (CCR) and NCI at Frederick recently had the honor of hosting Professor Dr. Her Royal Highness Princess Chulabhorn Mahidol of Thailand. Her Royal Highness has a special interest in scientific research related to the use of natural products for treating disease. The purpose of her visit was to discuss the work on natural products being undertaken at NCI at Frederick. Her Royal Highness attended talks by researchers from both the Molecular Targets Laboratory (MTL), CCR, and the Natural Products Branch (NPB), Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD).

  15. A l'écoute de nos instituts scientifiques.

    NASA Astrophysics Data System (ADS)

    Henrard, J.; Arnould, M.; Demaret, J.; Noels, A.; Vercheval, J.; Crommelynck, D.; Melchior, P.

    The authors give some important events which occurred during the last academic year 1981-1982 in six scientific institutes in Belgium (Groupe de mécanique céleste, Département de Mathématique, Facultés Universitaires de Namur; Institut d'Astronomie, d'Astrophysique et de Géophysique, Université Libre de Bruxelles; Institut d'Astrophysique, Université de Liège; l'Institut d'Aéronomie Spatiale de Belgique; Institut Royal Météorologique de Belgique; Observatoire Royal de Belgique).

  16. The Observers Observed: Charles Dickens at the Royal Observatory, Greenwich, in 1850

    NASA Astrophysics Data System (ADS)

    Chapman, A.

    2005-12-01

    In 1850 the magazine Household Words, which Charles Dickens edited, published three articles describing the instruments and workings of the Royal Observatory, Greenwich. These 'popular' articles are invaluable primary sources for the historian of astronomy. They convey some of the Victorian public's fascination with an Institution believed by some to be a lighthouse for night-time shipping on the river Thames; by others, a national repository of 'divining rods' and 'magic mirrors'. Dickens was clearly impressed by the pragmatic usefulness of the Observatory to a commercial and maritime nation, and by seemingly magical, self-acting and recording instruments whereby the wind wrote its own 'Aeolian Autobiography'.

  17. 2. Photocopy of a measured drawing (original delineated the Royal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of a measured drawing (original delineated the Royal Danish Academy of Fine Arts (Kunstakademiets), Copenhagen, Denmark, 1961) FRONT (KING STREET) ELEVATION AND PLANS OF FIRST AND SECOND FLOORS - Kongensgade 58 (House), 58 King Street, Christiansted, St. Croix, VI

  18. VIEW OF DATE DRIVE, SHOWING ROYAL PALMS ALONG THE STREET. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF DATE DRIVE, SHOWING ROYAL PALMS ALONG THE STREET. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

  19. Saving for Learning in the Netherlands. Research Report.

    ERIC Educational Resources Information Center

    Biggar, Sharon

    The Netherlands has been characterized by highly differentiated secondary education, with separate practical, vocational, secondary, and pre-university institutions. Over time, these have converged somewhat. Well-thought-out vocational and adult programs emphasize providing skills needed in the workplace. At least part-time education is compulsory…

  20. Electron spin resonance spectral analysis of irradiated royal jelly.

    PubMed

    Yamaoki, Rumi; Kimura, Shojiro; Ohta, Masatoshi

    2014-01-15

    The analysis of unpaired electron components in royal jelly was carried out using electron spin resonance (ESR) with the aim to develop a detection method for irradiated royal jelly. The ESR spectrum of royal jelly had natural signals derived from transition metals, including Fe(3+) and Cu(2+), and a signal line near g=2.00. After irradiation, a new splitting asymmetric spectrum with overall spectrum width ca. 10mT at g=2.004 was observed. The intensities of the signals at g=2.004 increased in proportion to the absorbed dose in samples under different storage conditions: fresh frozen royal jelly and dried royal jelly powder at room temperature. The signal intensity of the fresh frozen sample was stable after irradiation. One year after 10kGy irradiation of dried powder, the signal intensity was sevenfold greater than before irradiation, although the intensity continued to steadily decrease with time. This stable radiation-induced radical component was derived from the poorly soluble constituent of royal jelly.

  1. Meteorological variation in daily travel behaviour: evidence from revealed preference data from the Netherlands

    NASA Astrophysics Data System (ADS)

    Creemers, Lieve; Wets, Geert; Cools, Mario

    2015-04-01

    This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation (trip motives) and daily modal choices in the Netherlands. To this end, data from the Dutch National Travel Household Survey of 2008 were matched to hourly weather data provided by the Royal Dutch Meteorological Institute and were complemented with thermal indices to indicate the level of thermal comfort and additional variables to indicate the seasonality of the weather conditions. Two multinomial logit-generalised estimation equations (MNL-GEE) models were constructed, one to assess the impact of weather conditions on trip motives and one to assess the effect of weather conditions on modal choice. The modelling results indicate that, depending on the travel attribute of concern, other factors might play a role. Nonetheless, the thermal component, as well as the aesthetical component and the physical component of weather play a significant role. Moreover, the parameter estimates indicate significant differences in the impact of weather conditions when different time scales are considered (e.g. daily versus hourly based). The fact that snow does not play any role at all was unexpected. This finding can be explained by the relatively low occurrence of this weather type in the study area. It is important to consider the effects of weather in travel demand modelling frameworks because this will help to achieve higher accuracy and more realistic traffic forecasts. These will in turn allow policy makers to make better long-term and short-term decisions to achieve various political goals, such as progress towards a sustainable transportation system. Further research in this respect should emphasise the role of weather conditions and activity-scheduling attributes.

  2. Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography.

    PubMed

    Genç, M; Aslan, A

    1999-04-16

    In this research, several royal jellies and commercial products containing royal jelly were analysed for their trans-10-hydroxy-2-decenoic acid (10-HDA) content by using a column liquid chromatography technique. Ten samples claimed to be pure royal jelly, containing 10-HDA between 0.75 and 2.54%. Seven samples claimed to contain royal jelly as an ingredient which ranged from non-detectable to 0.054%. The technique was found to be rapid with high recovery.

  3. Royal jelly attenuates azathioprine induced toxicity in rats.

    PubMed

    Ahmed, Walaa M S; Khalaf, A A; Moselhy, Walaa A; Safwat, Ghada M

    2014-01-01

    In the present study, we investigated the potential protective effects of royal jelly against azathioprine-induced toxicity in rat. Intraperitoneal administration of azathioprine (50 mg/kgB.W.) induced a significant decrease in RBCs count, Hb concentration, PCV%, WBCs count, differential count and platelet count, hepatic antioxidant enzymes (reduced glutathione and glutathione s-transferase) and increase of serum transaminases (alanine aminotransferase and aspartate aminotransferase enzymes) activities, alkaline phosphatase and malondialdehyde formation. Azathioprine induced hepatotoxicity was reflected by marked pathological changes in the liver. Oral administration of royal jelly (200 mg/kgB.W.) was efficient in counteracting azathioprine toxicity whereas it altered the anemic condition, leucopenia and thrombocytopenia induced by azathioprine. Furthermore, royal jelly exerted significant protection against liver damage induced by azathioprine through reduction of the elevated activities of serum hepatic enzymes. Moreover, royal jelly blocked azathioprine-induced lipid peroxidation through decreasing the malondialdehyde formation. In conclusion, royal jelly possesses a capability to attenuate azathioprine-induced toxicity.

  4. Conservation genetics of the endangered Isle Royale gray wolf

    USGS Publications Warehouse

    Wayne, R.K.; Lehman, N.; Girman, D.; Gogan, P.J.P.; Gilbert, D.A.; Hansen, K.; Peterson, R.O.; Seal, U.S.; Eisenhawer, A.; Mech, L.D.; Krumenaker, R.J.

    1991-01-01

    The small group of wolves on Isle Royale has been studied for over three decades as a model of the relationship between large carnivores and their prey. During the last ten years the population declined from 50 individuals to as few as 12 individuals. The causes of this decline may be food shortages, disease, or reduced genetic variability. We address the issues of genetic variability and relationships of Isle Royale wolves using allozyme electrophoresis, mtDNA restriction-site analysis, and multilocus hypervariable minisatellite DNA analysis (genetic fingerprinting). Our results indicate that approximately 50% of the allozyme heterozygosity has been lost in the island population, a decline similar to that expected if no immigration had occurred from the mainland. The genetic fingerprinting data indicate that the seven sampled Isle Royale wolves are as similar as captive populations of siblings. Surprisingly, the Isle Royale wolves have an mtDNA genotype that is very rare on the mainland, being found in only one of 144 mainland wolves. This suggests that the remaining Isle Royale wolves are probably derived from a single female founder.

  5. Octanoic acid confers to royal jelly varroa-repellent properties

    NASA Astrophysics Data System (ADS)

    Nazzi, Francesco; Bortolomeazzi, Renzo; Della Vedova, Giorgio; Del Piccolo, Fabio; Annoscia, Desiderato; Milani, Norberto

    2009-02-01

    The mite Varroa destructor Anderson & Trueman is a parasite of the honeybee Apis mellifera L. and represents a major threat for apiculture in the Western world. Reproduction takes place only inside bee brood cells that are invaded just before sealing; drone cells are preferred over worker cells, whereas queen cells are not normally invaded. Lower incidence of mites in queen cells is at least partly due to the deterrent activity of royal jelly. In this study, the repellent properties of royal jelly were investigated using a lab bioassay. Chemical analysis showed that octanoic acid is a major volatile component of royal jelly; by contrast, the concentration is much lower in drone and worker larval food. Bioassays, carried out under lab conditions, demonstrated that octanoic acid is repellent to the mite. Field studies in bee colonies confirmed that the compound may interfere with the process of cell invasion by the mite.

  6. Wolves, moose, and tree rings on isle royale.

    PubMed

    McLaren, B E; Peterson, R O

    1994-12-02

    Investigation of tree growth in Isle Royale National Park in Michigan revealed the influence of herbivores and carnivores on plants in an intimately linked food chain. Plant growth rates were regulated by cycles in animal density and responded to annual changes in primary productivity only when released from herbivory by wolf predation. Isle Royale's dendrochronology complements a rich literature on food chain control in aquatic systems, which often supports a trophic cascade model. This study provides evidence of top-down control in a forested ecosystem.

  7. The development of HIV research laboratories in the Royal Thai Army Medical Department.

    PubMed

    Chuenchitra, Thippawan; Sukwit, Suchitra; Gaywee, Jariyanart; Viputtikul, Kwanjai; Eamsila, Chirapa; Tabprasit, Sutchana; de Souza, Mark; Sirisopana, Narongrid; Nitayaphan, Sorachai; Brown, Arthur E; Chuenchitra, Cheodchai

    2005-11-01

    The development of HIV research laboratories at the Armed Forces Research Institute of Medical Sciences (AFRIMS), Royal Thai Army Medical Department in supporting of HIV-1 vaccine trials in Thailand was implemented in 1991. The collaboration between AFRIMS, Royal Thai Army Medical Department, and the US Military HIV Research Program with the ultimate goal to conduct the HIV-1 vaccine trial phase III. The HIV serology lab was set up for surveillance program in military recruits. Then, there was a need to strengthen more on the existing laboratories by training personnel to cope with the confidentiality of the lab results, specimen processing and data management which are critical. Later on, the necessary laboratory for measuring of vaccine immunogenicity was developed, such as lymphoproliferation assay. Additionally, a molecular biology lab was also developed. The HIV research laboratory management must include an ability to deal with some problems, such as late specimen receiving, fluctuating of power supply, technical staffs maintained. Good laboratory practices and safety must be strictly implemented. Communication network among facilities also played an important role in HIV laboratory strengthening at AFRIMS.

  8. The Library of the Royal Society of Physicians in Budapest becomes today's Semmelweis Medical History Library

    PubMed Central

    Kaproncszay, Katalin; Magyar, László András; Putnam, Constance E

    2011-01-01

    Objectives: The 170-year history of the library of the Royal Society of Medicine in Budapest illustrates both that political and cultural context matter and that “medical” libraries, if they survive, in due course become primarily “medical history” libraries. Methods: Two of the authors are on the staff of the Semmelweis Medical History Library; the third is a US scholar who makes frequent use of the library. Together, they avail themselves of archival and published materials—and personal experience with the collection—to establish the context that produced the original library, trace its evolution, and describe its present-day incarnation. Results: A tale of transformation emerges that reflects how collections are likely to change. The authors present events and individuals in the life of the Royal Society's library and paint a picture of the value of today's Semmelweis Medical History Library. Unique treasures in the collection are described. Conclusion: The story told here is of how a particular nineteenth-century library became a twenty-first–century institution. The authors establish its peculiarly Hungarian context and potential value to librarians and historians from outside Hungary. The overall message is that general medical libraries everywhere are perforce likely to become medical historical libraries over time. PMID:21243053

  9. Making Kew Observatory: the Royal Society, the British Association and the politics of early Victorian science.

    PubMed

    Macdonald, Lee T

    2015-09-01

    Built in 1769 as a private observatory for King George III, Kew Observatory was taken over in 1842 by the British Association for the Advancement of Science (BAAS). It was then quickly transformed into what some claimed to be a 'physical observatory' of the sort proposed by John Herschel - an observatory that gathered data in a wide range of physical sciences, including geomagnetism and meteorology, rather than just astronomy. Yet this article argues that the institution which emerged in the 1840s was different in many ways from that envisaged by Herschel. It uses a chronological framework to show how, at every stage, the geophysicist and Royal Artillery officer Edward Sabine manipulated the project towards his own agenda: an independent observatory through which he could control the geomagnetic and meteorological research, including the ongoing 'Magnetic Crusade'. The political machinations surrounding Kew Observatory, within the Royal Society and the BAAS, may help to illuminate the complex politics of science in early Victorian Britain, particularly the role of 'scientific servicemen' such as Sabine. Both the diversity of activities at Kew and the complexity of the observatory's origins make its study important in the context of the growing field of the 'observatory sciences'.

  10. Royal Jelly: An ancient remedy with remarkable antibacterial properties.

    PubMed

    Fratini, Filippo; Cilia, Giovanni; Mancini, Simone; Felicioli, Antonio

    2016-11-01

    Royal Jelly (RJ), a honeybee hypopharyngeal gland secretion of young nurse and an exclusive nourishment for bee queen, has been used since ancient times for care and human health and it is still very important in traditional and folkloristic medicine, especially in Asia within the apitherapy. Recently, RJ and its protein and lipid components have been subjected to several investigations on their antimicrobial activity due to extensive traditional uses and for a future application in medicine. Antimicrobial activities of crude Royal Jelly, Royalisin, 10-hydroxy-2-decenoic acid, Jelleines, Major Royal Jelly Proteins against different bacteria have been reported. All these beehive products showed antimicrobial activities that lead their potential employment in several fields as natural additives. RJ and its derived compounds show a highest activity especially against Gram positive bacteria. The purpose of this Review is to summarize the results of antimicrobial studies of Royal Jelly following the timescale of the researches. From the first scientific applications to the isolation of the single components in order to better understand its application in the past years and propose an employment in future studies as a natural antimicrobial agent.

  11. ROYAL PALMLINED WALK TO FACILITY 1041 (QUARTERS J) WITH FACILITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ROYAL PALM-LINED WALK TO FACILITY 1041 (QUARTERS J) WITH FACILITY 1040 (QUARTERS 1) TO LEFT. TAKEN AT CORNER OF HALE ALII AVENUE AND EIGHTH STREET. VIEW FACING EAST. - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Hale Alii Avenue, Eighth Street, & Avenue D, Pearl City, Honolulu County, HI

  12. Photovoltaic-powered refrigerator experiment at Isle Royale National Park

    NASA Technical Reports Server (NTRS)

    Ratajczak, A. F.

    1977-01-01

    The use of a photovoltaic power system to operate an electric refrigerator at a trail construction camp at Isle Royale, Michigan is investigated. The use of P/V power for refrigeration in a remote installation is demonstrated. System design as well as predicted and measured system performance are presented.

  13. 1. Photocopy of measured drawing (original delineated by the Royal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of measured drawing (original delineated by the Royal Danish Academy of Fine Arts (Kunstakademiets), Copenhagen, Denmark, 1961) WEST ELEVATIONS AND PLAN OF UPPER DRONNINGENSGADE - Dronningensgade Area Study, Ninty-nine Steps, 30-31 Queen Street, Charlotte Amalie, St. Thomas, VI

  14. FACILITY 1042. FRONT OBLIQUE SHOWING ROYAL PALMS LINING FRONT WALK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACILITY 1042. FRONT OBLIQUE SHOWING ROYAL PALMS LINING FRONT WALK. VIEW FACING SOUTHEAST - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Junior Officers' Quarters Type, 9-10 Hale Alii Avenue, 1-2 Eighth Street, Pearl City, Honolulu County, HI

  15. Educational and Nonprofit Institutions Receiving Prime Contract Awards for RDT&E (Research, Development, Test and Evaluation), Fiscal Year 1988.

    DTIC Science & Technology

    1988-01-01

    ENG ED 3,770 m Chili Junction New York 50 Casa Bianco Florida 212 Troy New York 6,640 Saint Cloud Florida 2,488 Bedford Mass 350 RESEARCH FNDTN MTL HLTH...UNITED KIN 60 FRANCE 206 ROYAL INSTITUTION 35 CENTRO DI CULTURA SCIENTIFICA 33 * UNITED KIN 35 ITALY 33 ROYAL NORWEGIAN NAVAL MATERIAL 15,621

  16. More than royal food - Major royal jelly protein genes in sexuals and workers of the honeybee Apis mellifera

    PubMed Central

    2013-01-01

    Background In the honeybee Apis mellifera, female larvae destined to become a queen are fed with royal jelly, a secretion of the hypopharyngeal glands of young nurse bees that rear the brood. The protein moiety of royal jelly comprises mostly major royal jelly proteins (MRJPs) of which the coding genes (mrjp1-9) have been identified on chromosome 11 in the honeybee’s genome. Results We determined the expression of mrjp1-9 among the honeybee worker caste (nurses, foragers) and the sexuals (queens (unmated, mated) and drones) in various body parts (head, thorax, abdomen). Specific mrjp expression was not only found in brood rearing nurse bees, but also in foragers and the sexuals. Conclusions The expression of mrjp1 to 7 is characteristic for the heads of worker bees, with an elevated expression of mrjp1-4 and 7 in nurse bees compared to foragers. Mrjp5 and 6 were higher in foragers compared to nurses suggesting functions in addition to those of brood food proteins. Furthermore, the expression of mrjp9 was high in the heads, thoraces and abdomen of almost all female bees, suggesting a function irrespective of body section. This completely different expression profile suggests mrjp9 to code for the most ancestral major royal jelly protein of the honeybee. PMID:24279675

  17. Aircrew cooperation in the Royal Air Force

    NASA Technical Reports Server (NTRS)

    Adcock, C. B.

    1987-01-01

    The progressive introduction of modern, high performance aircraft, coupled with a significant increase in the complexity of the operational environment, has highlighted crew co-operation as a critical factor in aircraft safety. Investigation into recent MAC aircraft accidents supports the conclusion reached by NASA and other U.S. research institutions that a positive training program is required to improve resource management in the cockpit and prevent a breakdown under stress of the crew process. Past training and regulation has concentrated on the attainment of individual flying skills, but group skills have been neglected through lack of knowledge and understanding of the group process. This long-standing deficiency is now being addressed in the U.S. by the progressive and widespread introduction of theoretical and practical training programs to improve crew co-operation. The RAF should provide similar training for its aircrews through the adaptation and development of existing training resources. Better crew co-operation would not only reduce the number of RAF aircraft accidents but also improve the morale of the Service.

  18. Population limitation and the wolves of Isle Royale

    USGS Publications Warehouse

    Peterson, R.O.; Thomas, N.J.; Thurber, J.M.; Vucetich, J.A.; Waite, T.A.

    1998-01-01

    Population regulation for gray wolves in Isle Royale National Park, Michigan, was ex- amined in 1987-1995 when wolves were in chronic decline following a crash of the pop- ulation in 1981-1982. Canine parvovirus (CPV-2) was probably influential during the crash, but it disappeared by the lae 1980s. High mortality abruptly ceased after 1988, but low recruitment in the absence of disease and obvious shortage of food prevented recovery of the wolf population. In 1983-1995, with a comparable number of moose '10 years old as potential prey, wolves were only half as numerous as in 1959-1980. A simulation of annual fluctuations in effective population size (Ne) for wolves on Isle Royale suggests that their genetic heterozygosity has declined ca. 13% with each generation and ca. 80% in the 50- year history of this population. Inbreeding depression and stochastic demographic variation both remain possible explanations for recent low recruitment.

  19. The Magnetic Observatory Buildings at the Royal Observatory, Cape

    NASA Astrophysics Data System (ADS)

    Glass, I. S.

    2015-10-01

    During the 1830s there arose a strong international movement, promoted by Carl Friedrich Gauss and Alexander von Humboldt, to characterise the earth's magnetic field. By 1839 the Royal Society in London, driven by Edward Sabine, had organised a "Magnetic Crusade" - the establishment of a series of magnetic and meteorological observatories around the British Empire, including New Zealand, Australia, St Helena and the Cape. This article outlines the history of the latter installation, its buildings and what became of them.

  20. John Tyndall and the Royal Medal that was never struck

    PubMed Central

    Jackson, Roland

    2014-01-01

    Just once in its long history has a Royal Medal been awarded but not presented. John Tyndall FRS (1820–93) was the chosen recipient in 1853 for his early work on diamagnetism but declined to accept it. The story of why Tyndall felt compelled to turn down this considerable honour sheds light on the scientific politics and personal relationships of the time, on the importance given to the study of magnetism, and on Tyndall's own character and career. PMID:24921107

  1. A Compact Geography of the Netherlands. [Revised.

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    This short booklet on the geography of the Netherlands, designed for use at the upper elementary and secondary levels, contains 17 short descriptive analyses of Dutch physical and human geography. Each section is well illustrated with diagrams and maps. Titles of the sections include (1) High Netherlands--Low Netherlands, (2) Land Reclamation, (3)…

  2. Whitening Effect of Watersoluble Royal Jelly from South Korea.

    PubMed

    Han, Sang Mi; Kim, Jung Min; Hong, In Phyo; Woo, Soon Ok; Kim, Se Gun; Jang, Hye Ri; Park, Kwan Kyu; Pak, Sok Cheon

    2015-01-01

    Royal jelly has been widely used as a health supplement worldwide. However, royal jelly has been implicated in allergic reactions, and we developed a water-soluble royal jelly (WSRJ) without the allergy inducing protein. In this study, we aimed to identify the anti-melanogenic efficacy of WSRJ. B16F1 melanoma cells were first treated with 10 nM α-melanocyte stimulating hormone (α-MSH) and then with various doses of WSRJ. In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting. WSRJ directly inhibited tyrosinase and cellular tyrosinase activity, which decreased melanin synthesis in α-MSH stimulated B16F1 melanoma cells a level comparable to that observed with arbutin. WSRJ decreased the mRNA and protein expressions of tyrosinase, TRP-1, and TRP-2, which was comparable to that observed with arbutin. WSRJ has strong anti-melanogenic activity, which invoice direct inhibition of tyrosinase enzyme activity and suppression of expression of melanogenesis related genes. Results from this study suggests that WSRJ is a potential candidate for the treatment of skin pigmentation.

  3. Functional properties of honey, propolis, and royal jelly.

    PubMed

    Viuda-Martos, M; Ruiz-Navajas, Y; Fernández-López, J; Pérez-Alvarez, J A

    2008-11-01

    Honey, propolis, and royal jelly, products originating in the beehive, are attractive ingredients for healthy foods. Honey has been used since ancient times as part of traditional medicine. Several aspects of this use indicate that it also has functions such as antibacterial, antioxidant, antitumor, anti-inflamatory, antibrowning, and antiviral. Propolis is a resinous substance produced by honeybees. This substance has been used in folk medicine since ancient times, due to its many biological properties to possess, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects, among others. Royal jelly has been demonstrated to possess numerous functional properties such as antibacterial activity, anti-inflammatory activity, vasodilative and hypotensive activities, disinfectant action, antioxidant activity, antihypercholesterolemic activity, and antitumor activity. Biological activities of honey, propolis, and royal jelly are mainly attributed to the phenolic compounds such as flavonoids. Flavonoids have been reported to exhibit a wide range of biological activities, including antibacterial, antiviral, anti-inflammatory, antiallergic, and vasodilatory actions. In addition, flavonoids inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and the activity of enzyme systems including cyclo-oxygenase and lipoxygenase.

  4. Geohydrologic data from Port Royal Sound, Beaufort County, South Carolina

    USGS Publications Warehouse

    Burt, R.A.; Belval, D.L.; Crouch, Michael; Hughes, W.B.

    1986-01-01

    Nine offshore wells were drilled through overlying sediments into the Upper Floridan aquifer in Port Royal Sound, South Carolina and the adjacent Atlantic Ocean, to obtain geologic, hydrologic, and water quality data. The Upper Floridan aquifer consists predominantly of light-gray, poorly consolidated, fossiliferous limestone. In the Port Royal Sound area, the Upper Floridan is overlain by olive-gray, medium to course sand and silty sand. Falling-head permeability tests on these overlying clastic sediments indicate permeabilities of 1,100 to 4.3 x 10 to the 7th power centimeters/sec. Other geologic and hydrologic data, including geophysical logs, sieve analyses, and detailed core descriptions were obtained, along with continuous water level records of the wells, tidal records, and barometric pressure records. Water collected from the Upper Floridan aquifer beneath Port Royal Sound and the ocean ranged in concentration of chloride from 54 to 12,000 mg/l. Measured pH ranged from 6.8 to 8.4, and alkalinity ranged from 122 to 368 mg/l as CaC03. Other water quality data obtained include temperature, specific conductance, carbon-13, carbon-14, tritium , deuterium, oxygen-18, dissolved oxygen, dissolved solids, nitrogen species, phosphorus, organic carbon, cyanide, sulfide, calcium, magnesium, sodium, potassium, sulfate, fluoride, silica , bromide, iodide, and selected trace metals. (USGS)

  5. Institute news

    NASA Astrophysics Data System (ADS)

    1999-11-01

    : Heriot-Watt University 4 Nov: Strathclyde University 17 Nov: York University 24 Nov: Bristol University 1 Dec: Open University 7 Dec: Kent University 14 Dec: Cardiff University 15 Dec: University of Wales, Swansea 24 Jan: Reading University 10 Feb: Abingdon School 16 Feb: Plymouth University 2 Mar: Sheffield University 7 Mar: CLRC Daresbury Laboratory 8 Mar: Liverpool University 9 Mar: Manchester 10 Mar: Lancaster University 15 Mar: Surrey University 16 Mar: Brighton University 17 Mar: St Vincent College, Gosport 22 Mar: Leeds University 23 Mar: Loughborough Grammar School 24 Mar: Oakham School 30 Mar: St Peter's School, Wolverhampton 18 May: University of Hertfordshire 11 Jul: Science Museum 12 Jul: Royal Institution The assistance of the Engineering and Physical Sciences Research Council, CLRC Daresbury Laboratory and DERA Malvern is acknowledged in staging this year's events. Courses, lectures and competitions `Physics in perspective', the study course for sixth-formers and college students, will take place in London on 6 - 8 February 2000, offering insights into many different aspects of physics. The programme commences during the afternoon of Sunday 6 February at King's College London with a Balloon debate, followed by Brian O'Rourke's talk on the `Physics of Formula 1 cars'. On Monday 7 February at the Royal Institution, John Avison (former Honorary Editor of Physics Education) will develop the `Thinking physics' theme by presenting the audience with varied topics in an unusual and challenging way. The second talk of the afternoon, by Professor Roy Sambles, will cover `Lasers, light and liquid crystals'. On the final day (Tuesday 8 February), again at the Royal Institution, Sara Ellison will lead the audience in `Heavenly pursuits', whilst later Dr Colin Wright will entertain with `Juggling - theory and practice'. Futher information and bookings for the course can be made by contacting Mrs Leila Solomon at The Institute of Physics, 76 Portland Place, London W1N 3DH

  6. Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis

    PubMed Central

    Yamaura, Katsunori; Tomono, Ayana; Suwa, Eriko; Ueno, Koichi

    2013-01-01

    Background: Royal jelly is widely used as a health tonic, especially in Asia. Royal jelly is commonly used in cosmetics as well as in dietary supplements and beverages. Little is known, however, about the pharmacologic efficacy of topical royal jelly. Therefore, we investigated the antipruritic activity of topical royal jelly on chronic pruritus in experimental allergic contact dermatitis in mice. Materials and Methods: Hairless mice (HOS: HR-1), with chronic allergic contact dermatitis induced by 5 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) to the entire back skin were treated topically with royal jelly (0.01% or 1%) for 5 weeks after sensitization with TNCB. The effects of royal jelly on pruritus and inflammation were evaluated by measurement of scratching behavior and skin inflammation score, respectively. Results: Repeated application of TNCB to the back skin of mice elicited frequent scratching behavior immediately and 24h after challenge. Topical royal jelly (0.01% or 1%) and betamethasone (0.01%) significantly ameliorated this chronic pruritus throughout the experimental period. The level of nerve growth factor mRNA in back skin was increased in the mice with dermatitis and reduced by betamethasone, but not by royal jelly. Conclusion: The inhibitory effect of royal jelly on chronic pruritus may occur through different mechanisms from those of betamethasone. Topical application of royal jelly, as used in cosmetics, might be beneficial for the alleviation of chronic pruritus. PMID:23661987

  7. Pictorial Atlas of the Netherlands.

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    The atlas contains almost 40 photographs and 40 maps of geographical aspects of the Netherlands: the coast, dikes, canals, towns, and farmland. Each page contains a photograph, a section of a map showing the area in which the photograph was taken, and a discussion of several paragraphs about the geographical problems of the area and how they have…

  8. Higher Education in the Netherlands.

    ERIC Educational Resources Information Center

    de Moor, R. A.

    There are two sectors of higher education in the Netherlands: the universities covered by the University Education Act and the vocationally-oriented colleges covered by the Further Education Act. Following a summary of the main elements of secondary education, higher or tertiary education is defined. Thirteen universities and non-university…

  9. Reproductive technology: in the Netherlands, tolerance and debate.

    PubMed

    De Wachter, Maurice A M; De Wert, Guido MWR

    1987-06-01

    Two ethicists from the Netherlands' Institute for Bioethics file a report on their country in one of six Hastings Center Report articles on the status of reproductive technologies around the world. The situation in the Netherlands reflects the tolerant attitudes of the Dutch toward what are regarded as private matters. Artificial insemination, in vitro fertilization, and surrogate motherhood are available, and research on embryos is in the planning stages. Facilities offering reproductive services are regulated by the Minister of Health, with advice from the independent Health Council on Artificial Reproduction, the National Council for Public Health, and various insurance companies and professional medical organizations. Public policy debates center around such issues as the value of parenthood; involvement of third parties; secrecy about a child's genetic origins; privacy for semen, ovum, and embryo donors; access to services; and insurance coverage of treatment.

  10. KIBOWI: A Training Wargame for the Royal Netherlands Army (KIBOWI: Een Training Wargame voor de Koninklijke Landmacht)

    DTIC Science & Technology

    1989-12-01

    gebruik van het model heeft plaatsgevonden gedurende 1988 en 1989 voor circa 20 weken op bataljonsniveau. Ervaring in het gebruik van het prototype...representatie en eenheidsinteractie (detectie, direct vuur, etc.). TNO report Page 4 CONTENTS ABSTRACT 1 SAMENVATTING 2 CONTENTS 4 1 INTRODUCTION 6 2 THE...processes, readjusting for hardware failures, making backups, restarts, etc. 2. Database manager To create exercise databases and to facilitate and

  11. The geologic story of Isle Royale National Park

    USGS Publications Warehouse

    Huber, N. King

    1975-01-01

    Isle Royale is an outstanding example of relatively undisturbed northwoods lake wilderness. But more than simple preservation of such an environment is involved in its inclusion in our National Park System. Its isolation from the mainland provides an almost untouched laboratory for research in the natural sciences, especially those studies whose very nature depends upon such isolation. One excellent example of such research is the intensive study of the predator-prey relationship of the timber wolf and moose, long sponsored by the National Park Service and Purdue University. In probably no other place in North America are the necessary ecological conditions for such a study so admirably fulfilled as on Isle Royale. The development of a natural laboratory with such conditions is ultimately dependent upon geologic processes and events that although not unique in themselves, produced in their interplay a unique result, the island archipelago as we know it today, with its hills and valleys, swamps and bogs the ecological framework of the plant and animal world. Even the most casual visitor can hardly fail to be struck by the fiordlike nature of many of the bays, the chains of fringing islands, the ridge-and-valley topography, and the linear nature of all these features. The distinctive topography of the archipelago is, of course, only the latest manifestation of geologic processes in operation since time immemorial. Fragments of geologic history going back over a billion years can be read from the rocks of the island, and with additional data from other parts of the Lake Superior region, we can fill in some of the story of Isle Royale. After more than a hundred years of study by man, the story is still incomplete. But then, geologic stories are seldom complete, and what we do know allows a deeper appreciation of one of our most naturally preserved parks and whets our curiosity about the missing fragments.

  12. Royal Society offers funds for technology start-ups

    NASA Astrophysics Data System (ADS)

    Clery, Daniel

    2008-04-01

    Scientists with a good idea ripe for commercial exploitation will no longer have to hawk their wares to bankers and private investors to get financial backing: the Royal Society is also about to get into the venture-capital business. The society is planning to set up an enterprise fund to buy equity in start-up companies based on outstanding technology - covering everything from renewable energy and carbon capture to water purification. "If there are difficulties getting science into the marketplace, the society has a role helping with that," says chemical physicist Andrew Mackintosh, a former chief executive of Oxford Instruments who has been brought in to manage the fund.

  13. The Royal Society and the decline of magic.

    PubMed

    Hunter, Michael

    2011-06-20

    Whereas some have asserted that the early Royal Society actively sought to discredit magical beliefs, others have seen ideas of this kind as integral to the Society's 'nature' in its early years. This paper argues that, whatever the magical commitments of individual Fellows, the Society's corporate policy simply sidelined such pursuits. Yet, insofar as the result was that magic was excluded by default from the proper realm of scientific enquiry, this attitude was to prove paradoxically influential (although its roots have been retrospectively misconstrued to an extent that is significant in itself).

  14. Clinical photograph from the Royal Infirmary of Edinburgh - 1853.

    PubMed

    Malcolm-Smith, N A

    2005-10-01

    A child with a facial defect is presented using clinical details recorded in a ward journal of the Royal Infirmary of Edinburgh for 1853. The entry in the journal is illustrated by a clinical photograph and a pen and ink drawing. The operation for facial reconstruction is described together with an account of post-operative course and outcome. The differential diagnoses and views on the aetiology of the patient's disorder are considered. The photograph itself is described and the historical and social background of the patient are outlined.

  15. [The National Royal Academy of Medicine and the Civil War (1936-1939)].

    PubMed

    Sánchez Granjel, Luis

    2006-01-01

    The Civil war (1936-1939) caused the most serious crisis in the history of the National Royal Academy of Medicine. The Government of the Republic ordered its dissolution in September 1936, and they proposed the creation of a higher organization, "The National Institute of Culture", whose main aim was to join all the Academies that had become sections and that were rigidly controlled by the political power; the course of the war sotpped this project being carried out. In the army-dominated Spain there was a similar process; the "Institute of Spain" (January, 1938) was created and it joined the National Academies although each of them did not lose its own personality. The Academy of Medicine was established in San Sebastian until 1939, and was managed by Enrique Suñer, with the collaboration of Leonardo de la Peña and Santiago Carro; the three of them were named by the Ministry of National Education. The dispersion of the members of the Academy, who had abandoned Madrid, did not allow the Academy to develop its traditional scientific activity, which was not restored until the activity was re-established in Madrid in the summer of 1939.

  16. 78 FR 77772 - Culturally Significant Objects Imported for Exhibition Determinations: “A Royal Passion: Queen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Photography'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``A Royal Passion: Queen Victoria and Photography,'' imported from abroad for temporary...

  17. Xenotransplantation: perspectives from The Netherlands.

    PubMed

    van Rongen, E

    1998-12-30

    Recently, the Health Council of the Netherlands published a report on xenotransplantation. The technique is considered ethically acceptable, both from a human and from an animal point of view. Clinical application should not yet be permitted, however, because of continuing rejection problems and growing concerns on safety aspects associated with possible transfer of pathogens from the xenotransplant to the host. More research is necessary. Mainly because of the risk for infection, nonhuman primates are not considered acceptable as source animals; the genetically engineered pig is at present the source animal of choice. Legally, import in the Netherlands of (organs from) source animals from within Europe is difficult to prevent. Therefore experiments with such material are not subjected to licensing by the government, which is the case for experiments involving genetic engineering with animals in the Netherlands, but only by local review boards. This situation is considered unwanted and adjustment of the pertinent law is suggested. Also, both genetically engineered animals and patients carrying organs from such animals fall under the European Genetically Modified Organisms regulations. These regulations are not designed for this case and conflicts may arise. Agreements on how to handle this situation have to be made at the European level. It is proposed to draft a national law on "biologicals," medical products consisting at least partly of living materials. Pending such regulations, it is suggested, also on a European level, that xenotransplants be considered as medicines, which would allow adequate control of safety aspects.

  18. Medical education in The Netherlands.

    PubMed

    Ten Cate, Olle

    2007-10-01

    This paper aims to draw a picture of current medical education in The Netherlands. Based on strong historical roots in the seventeenth century, Dutch medical education has adapted to changing circumstances through the ages. Nowadays, medical education in The Netherlands may be called "modern", according to international standards and schools such as the one in Maastricht serve as examples, nationally and internationally. After considerable redesign of undergraduate education in the 1980s and 1990s, the first decade of the new century shows a revolutionary development of postgraduate medical education, with the introduction of nationwide competency-based training, and mandatory in-training assessments and portfolios for residents. The high level of activity in medical education development is reflected in high research productivity, measured as Dutch articles in international journals. Despite these strengths, several critical issues around medical education are in debate, ranging from entrance selection, small group tutoring, the two-cycle bachelor-master model and the relevance of basic sciences to the planning of enrolment numbers and working hours for residents. Medical education in The Netherlands is a dynamic field.

  19. Emergency departments in The Netherlands.

    PubMed

    Thijssen, Wendy A M H; Giesen, Paul H J; Wensing, Michel

    2012-01-01

    Emergency medicine in The Netherlands is faced with an increasing interest by politicians and stakeholders in health care. This is due to crowding, increasing costs, criticism of the quality of emergency care, restructuring of out-of-hours services in primary care and the introduction of a training programme for emergency physicians in 2000. A comprehensive search was conducted of published research, policy reports and updated Dutch websites on acute care. Publications were included in this review if these referred to emergency care, including emergency departments (ED), general practitioner (GP) cooperatives and emergency medical services in The Netherlands and were written in English or Dutch. The literature search identified 14 eligible papers. The manual search identified 11 additional papers. Seven reports and two PhD theses were also included. Given the lack of relevant empirical research the review was liberal in its inclusion, but the analysis focused on research when available. ED in The Netherlands are in different stages of development. However, it is obvious that the presence of emergency physicians is increasing and more ED will be staffed by emergency physicians. Although this seems an important step, it does not necessarily imply a good position of the emergency physician in the ED. What the characteristics of the future patient of the Dutch ED will be is dependent on the development of different ED levels of care and GP cooperatives. The lack of empirical research also points out the need for research on quality of care in Dutch ED.

  20. Pre-service Teachers' Beliefs about Inclusive Education in the Netherlands: In Exploratory Study

    ERIC Educational Resources Information Center

    Civitillo, Sauro; De Moor, Jan M. H.; Vervloed, Mathijs P. J.

    2016-01-01

    Teachers' beliefs are crucial to the success of inclusion programmes and reform efforts for children with special educational needs (SEN). Based on this evidence, one hundred and thirty-nine primary pre-service teachers from one training institution in the Netherlands completed an adapted version of a measure of beliefs towards inclusive…

  1. Design Research in the Netherlands: Introducing Logarithms Using Realistic Mathematics Education

    ERIC Educational Resources Information Center

    Webb, David C.; van der Kooij, Henk; Geist, Monica R.

    2011-01-01

    This article describes Realistic Mathematics Education (RME), a design theory for mathematics education proposed by Hans Freudenthal and developed over 40 years of developmental research at the Freudenthal Institute for Science and Mathematics Education in the Netherlands. Activities from a unit to develop student understanding of logarithms are…

  2. Training in the Retail Trade in the Netherlands. Report for the FORCE Programme. First Edition.

    ERIC Educational Resources Information Center

    van den Tillaart, Harry

    An international team of researchers studied the following aspects of training in the Netherlands' retail sector: structure and characteristics, institutional and social context, employment and labor, changing conditions and their implications for skill requirements, and training and recruitment. Data were collected from an analysis of social and…

  3. Poster Session Presentation [from the Netherlands] [and] Seen at Close Quarters.

    ERIC Educational Resources Information Center

    Bergers, Ton

    Two papers examine vocational training, special education, and government services for the disabled in the Netherlands. Originally presented at a convention poster session of the 16th World Congress of Rehabilitation International, the first paper focuses on the national institute at Werkenrode which provides a residential practice-based education…

  4. 75 FR 30431 - Carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... COMMISSION Carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden AGENCY: United States... on carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden. SUMMARY: The Commission... carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden would be likely to lead to continuation...

  5. Experiences of New Faculty in a Transitional Institution

    ERIC Educational Resources Information Center

    Yeo, Michelle; Bennett, Deb; Merkley, Cari; McNichol, Jane; Osakwe, Carlton; Pada, Carolyn

    2010-01-01

    This research project studies the induction and socialization of new faculty at Mount Royal University, recently transitioned from college to undergraduate university status. There is extensive documentation in the literature on issues faced by new faculty in post-secondary institutions; however, very little is published on how a culture in flux…

  6. Gradual Retirement in the Netherlands: An Analysis Using Administrative Data.

    PubMed

    Bloemen, Hans; Hochguertel, Stefan; Zweerink, Jochem

    2016-02-01

    Gradual retirement by which individuals leave their career jobs and withdraw incrementally from the labor force is an important empirical phenomenon in the United States. We analyze the current state of gradual retirement in the Netherlands using administrative data that allow much more precise tracking of labor market transitions than most survey panel data. We estimate multinomial transition models, taking into account competing pathways out of career employment at older ages, and discuss institutional aspects that limit the scope of gradual retirement, such as financial incentives to retire early.

  7. 76 FR 37300 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Royal Fiberglass Pools...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ...EPA is proposing to approve into the Illinois State Implementation Plan (SIP) an adjusted standard for Royal Fiberglass Pools (``Royal'') at its Dix, Illinois facility. On November 8, 2010, the Illinois Environmental Protection Agency (IEPA) submitted to EPA for approval an adjustment to the general rule, Use of Organic Material Rule, commonly known as the eight pound per hour (8 lb/hr) rule,......

  8. 78 FR 42512 - Application to Export Electric Energy; Royal Bank of Canada

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... Application to Export Electric Energy; Royal Bank of Canada AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Royal Bank of Canada (RBC) has applied to renew its authority to transmit electric energy from the United States to Canada pursuant to section 202(e) of...

  9. The portrait of Dr William Harvey in the Royal Society since 1683.

    PubMed

    Keynes, Milo

    2006-09-22

    A portrait of William Harvey in the Royal Society since 1683 is a copy by an unknown artist after a portrait, now lost, painted by Sir Peter Lely ca. 1650. Three other unattributed copies besides a copy bought from Lely's studio on his death by the Earl of Bradford have been located. The present labelling of the Royal Society portrait should be corrected.

  10. Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The major royal-jelly proteins (MRJPs) are the main constituents responsible for the specific physiological role of royal jelly (RJ) in honeybees. Male and female Drosophila flies were fed diets containing either no MRJPs (A) or casein (B) at 1.25% (w/w) of diet or MRJPs at 1.25% (C), 2.50% (D), or ...

  11. Flamsteed's stars. New perspectives on the life and work of the first Astronomer Royal (1646 - 1719).

    NASA Astrophysics Data System (ADS)

    Willmoth, F.

    Contents: 1. Introduction: the King's "astronomical observer". 2. Flamsteed's career in astronomy: nobility, morality and public utility (J. Bennett). 3. Astronomy and strife: John Flamsteed and the Royal Society (M. Feingold). 4. Models for the practice of astronomy: Flamsteed, Horrocks and Tycho (F. Willmoth). 5. Flamsteed's optics and the identity of the astronomical observer (A. Johns). 6. Equipping an observatory: Flamsteed and Molyneux discuss an astronomical quadrant (H. Higton). 7. Mathematical characters: Flamsteed and Christ's Hospital Royal Mathematical School (R. Iliffe). 8. "Professor" John Flamsteed (I. G. Stewart). 9. Edmond Halley and John Flamsteed at the Royal Observatory (A. Cook). 10. A unique copy of Flamsteed's Historia coelestis (1712) (O. Gingerich). 11. "Labour harder than thrashing": John Flamsteed, property and intellectual labour in nineteenth-century England (W. J. Ashworth). 12. The Flamsteed papers in the archives of the Royal Greenwich Observatory. (A. Perkins). A summary catalogue of Flamsteed's papers in the Royal Greenwich Observatory archives (compiled by F. Willmoth).

  12. Hearing loss in the Royal Norwegian Navy: A longitudinal study

    PubMed Central

    Irgens-Hansen, Kaja; Baste, Valborg; Bråtveit, Magne; Lind, Ola; Koefoed, Vilhelm F.; Moen, Bente E

    2016-01-01

    The aims of this longitudinal study were to investigate a significant threshold shift (STS) among personnel working on board the Royal Norwegian Navy's (RNoN) vessels between 2012 and 2014 and to identify possible determinants of STS. Hearing thresholds were measured by pure tone audiometry in two consecutive examinations (n = 226). STS was defined as an average change in hearing thresholds ≥ + 10 dB at 2,000 Hz, 3,000 Hz, and 4,000 Hz in either ear. Determinants of STS were assessed through a questionnaire. The incidence of STS was 23.0%. Significant determinants of STS were the number of episodes of temporary threshold shifts (TTS) in the Navy, exposure to continuous loud noise during work on board, and the number of gun shots (in the Navy, hunting, and sports). This study indicated a significant association between noise exposure on board Navy vessels and development of STS. PMID:27157689

  13. Compliance of Royal Naval ships with nitrogen oxide emissions legislation.

    PubMed

    Blatcher, D J; Eames, I

    2013-09-15

    Nitrogen oxide (NOx) emissions from marine diesel engines pose a hazard to human health and the environment. From 2021, demanding emissions limits are expected to be applied to sea areas that the Royal Navy (RN) accesses. We analyze how these future constraints affect the choice of NOx abatement systems for RN ships, which are subject to more design constraints than civilian ships. A weighted matrix approach is used to facilitate a quantitative assessment. For most warships to be built soon after 2021 Lean Nitrogen Traps (LNT) in conjunction with Exhaust Gas Recirculation (EGR) represents a relatively achievable option with fewer drawbacks than other system types. Urea-selective catalytic reduction is likely to be most appropriate for ships that are built to civilian standards. The future technologies that are at an early stage of development are discussed.

  14. Mapping the royal road and other hierarchical functions.

    PubMed

    Wiles, Janet; Tonkes, Bradley

    2003-01-01

    In this paper we present a technique for visualising hierarchical and symmetric, multi-modal fitness functions that have been investigated in the evolutionary computation literature. The focus of this technique is on landscapes in moderate-dimensional, binary spaces (i.e., fitness functions defined over [0,1](n), for n < or = 16). The visualisation approach involves an unfolding of the hyperspace into a two-dimensional graph, whose layout represents the topology of the space using a recursive relationship, and whose shading defines the shape of the cost surface defined on the space. Using this technique we present case-study explorations of three fitness functions: royal road, hierarchical-if-and-only-if (H-IFF), and hierarchically decomposable functions (HDF). The visualisation approach provides an insight into the properties of these functions, particularly with respect to the size and shape of the basins of attraction around each of the local optima.

  15. Outbreak of Legionnaires' disease in Glasgow Royal Infirmary: microbiological aspects.

    PubMed Central

    Timbury, M. C.; Donaldson, J. R.; McCartney, A. C.; Fallon, R. J.; Sleigh, J. D.; Lyon, D.; Orange, G. V.; Baird, D. R.; Winter, J.; Wilson, T. S.

    1986-01-01

    The bacteriological investigation of an outbreak of Legionnaires' disease in Glasgow Royal Infirmary affecting 16 patients is described. Most of the patients had been treated in high-dependency areas on two floors of the hospital supplied by the same two air-conditioned ventilation systems. The source of infection was traced to contamination of a cooling tower from which a plume of spray discharged into the intake vents of the two ventilation systems. Rubber grommets within the cooling tower probably provided a nidus of infection there. The control and management of the outbreak are discussed: a policy of frankness about the course and progress of the investigations was adopted and helped to allay anxiety on the part of both staff and media. PMID:3540109

  16. Dental caries amongst Royal Australian Navy recruits, 1988.

    PubMed

    Morgan, M V; Stonnill, A; Laslett, A M

    1992-06-01

    A sample of 1100 Royal Australian recruits were examined for dental caries in 1988. Socio-demographic data were also collected. The mean DMFT scores were 4.33, 6.85, and 8.87 teeth for the 15-19 year-olds, 20-24 year-olds, and 25-29 year-olds, respectively. Caries experience varied between the state of origin of recruitment with Victorian and Queensland subjects having the highest DMFT scores, and Tasmanian subjects, the lowest. Comparison with previous military studies indicated not only a decreased dental caries experience, but also that restoration of teeth rather than extraction is a more likely treatment outcome of dental caries in recent recruits.

  17. Cutaneous leishmaniasis in Royal Marines from Oruzgan, Afghanistan.

    PubMed

    Matheson, A; Williams, R; Bailey, M S

    2012-09-01

    Leishmaniasis is an infectious disease caused by Leishmania protozoa and occurs as a spectrum of clinical syndromes ranging from various forms of cutaneous leishmaniasis (CL) to mucosal leishmaniasis (ML) and visceral leishmaniasis (VL). CL in Afghanistan is either zoonotic (ZCL) due to L. major or anthroponotic (ACL) due to L. tropica and there has been a prolonged epidemic of ACL in eastern Afghanistan since 1987. However, there have been remarkably few reports of CL due to L. tropica amongst foreign troops serving in Afghanistan since 2001. We describe two such cases in Royal Marines deployed to Oruzgan Province in Afghanistan from 2008-9. These patients illustrate important issues regarding the clinical features, referral, diagnosis, treatment and epidemiology of CL amongst foreign troops in Afghanistan. This disease has the potential to cause significant disruption to military personnel and units and so requires efficient management in order to maintain operational effectiveness.

  18. Royal dynasties as human inbreeding laboratories: the Habsburgs

    PubMed Central

    Ceballos, F C; Álvarez, G

    2013-01-01

    The European royal dynasties of the Early Modern Age provide a useful framework for human inbreeding research. In this article, consanguineous marriage, inbreeding depression and the purging of deleterious alleles within a consanguineous population are investigated in the Habsburgs, a royal dynasty with a long history of consanguinity over generations. Genealogical information from a number of historical sources was used to compute kinship and inbreeding coefficients for the Habsburgs. The marriages contracted by the Habsburgs from 1450 to 1750 presented an extremely high mean kinship (0.0628±0.009), which was the result of the matrimonial policy conducted by the dynasty to establish political alliances through marriage. A strong inbreeding depression for both infant and child survival was detected in the progeny of 71 Habsburg marriages in the period 1450–1800. The inbreeding load for child survival experienced a pronounced decrease from 3.98±0.87 in the period 1450–1600 to 0.93±0.62 in the period 1600–1800, but temporal changes in the inbreeding depression for infant survival were not detected. Such a reduction of inbreeding depression for child survival in a relatively small number of generations could be caused by elimination of deleterious alleles of a large effect according with predictions from purging models. The differential purging of the infant and child inbreeding loads suggest that the genetic basis of inbreeding depression was probably very different for infant and child survival in the Habsburg lineage. Our findings provide empirical support that human inbreeding depression for some fitness components might be purged by selection within consanguineous populations. PMID:23572123

  19. Long-term breeding phenology shift in royal penguins.

    PubMed

    Hindell, Mark A; Bradshaw, Corey J A; Brook, Barry W; Fordham, Damien A; Kerry, Knowles; Hull, Cindy; McMahon, Clive R

    2012-07-01

    The Earth's climate is undergoing rapid warming, unprecedented in recent times, which is driving shifts in the distribution and phenology of many plants and animals. Quantifying changes in breeding phenology is important for understanding how populations respond to these changes. While data on shifts in phenology are common for Northern Hemisphere species (especially birds), there is a dearth of evidence from the Southern Hemisphere, and even fewer data available from the marine environment. Surface air temperatures at Macquarie Island have increased by 0.62°C during the 30-year study period (0.21°C decade(-1)) and royal penguins (Eudyptes schlegeli) commenced egg laying on average three days earlier in the 1990s than during the 1960s. This contrasts with other studies of Southern Ocean seabirds; five of nine species are now breeding on average 2.1 days later than during the 1950s. Despite the different direction of these trends, they can be explained by a single underlying mechanism: resource availability. There was a negative relationship between the Southern Annular Mode (SAM) and median laying date of royal penguins, such that low-productivity (low SAM) years delayed laying date. This accords with the observations of other seabird species from the Antarctic, where later laying dates were associated with lower sea ice and lower spring productivity. The unifying factor underpinning phenological trends in eastern Antarctica is therefore resource availability; as food becomes scarcer, birds breed later. These changes are not uniform across the region, however, with resource increases in the subantarctic and decreases in eastern Antarctica.

  20. Long-term breeding phenology shift in royal penguins

    PubMed Central

    Hindell, Mark A; Bradshaw, Corey J A; Brook, Barry W; Fordham, Damien A; Kerry, Knowles; Hull, Cindy; McMahon, Clive R

    2012-01-01

    The Earth's climate is undergoing rapid warming, unprecedented in recent times, which is driving shifts in the distribution and phenology of many plants and animals. Quantifying changes in breeding phenology is important for understanding how populations respond to these changes. While data on shifts in phenology are common for Northern Hemisphere species (especially birds), there is a dearth of evidence from the Southern Hemisphere, and even fewer data available from the marine environment. Surface air temperatures at Macquarie Island have increased by 0.62°C during the 30-year study period (0.21°C decade−1) and royal penguins (Eudyptes schlegeli) commenced egg laying on average three days earlier in the 1990s than during the 1960s. This contrasts with other studies of Southern Ocean seabirds; five of nine species are now breeding on average 2.1 days later than during the 1950s. Despite the different direction of these trends, they can be explained by a single underlying mechanism: resource availability. There was a negative relationship between the Southern Annular Mode (SAM) and median laying date of royal penguins, such that low-productivity (low SAM) years delayed laying date. This accords with the observations of other seabird species from the Antarctic, where later laying dates were associated with lower sea ice and lower spring productivity. The unifying factor underpinning phenological trends in eastern Antarctica is therefore resource availability; as food becomes scarcer, birds breed later. These changes are not uniform across the region, however, with resource increases in the subantarctic and decreases in eastern Antarctica. PMID:22957162

  1. Compact Geography of the Netherlands. Fifth Edition.

    ERIC Educational Resources Information Center

    Meijer, H.

    A short, concise summary of the geography of the Netherlands is presented in this document. The introduction describes the country's governmental forms, physical location, provinces, population, and history. Geographic coverage includes: (1) the high and low Netherlands; (2) the struggle against flooding and land reclamation; (3) the polders, or…

  2. Protective Effect of Royal Jelly on In Vitro Fertilization (IVF) in Male Mice Treated with Oxymetholone

    PubMed Central

    Zahmatkesh, Ensieh; Najafi, Gholamreza; Nejati, Vahid

    2015-01-01

    Objective This study aimed to investigate the effects of royal jelly (RJ) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (OXM). Materials and Methods In this exprimental study, 32 male and 96 female adult Naval Medical Research Institute (NMRI) mice (7-9 weeks of age) with a ratio of 1:3 for fertili- zation purposes were randomly divided into 4 groups as follows: i. Control group (n=8) receiving 0.1 ml/mice saline daily by gavage for 30 day, ii. RJ group (n=8) treated with RJ at a dose of 100 mg/kg daily by gavage for 30 days, iii. OXM group (n=8) receiving OXM at the dose of 5 mg/kg daily by gavage for 30 days and iv. RJ+OXM group (n=8) receiving RJ at the dose of 100 mg/kg daily by gavage concomitant with 100 mg/kg OXM adminis- tration for 30 days. Results Analysis revealed a significant reduction in catalase, total antioxidant, as well as embryo development in OXM group (P<0.05). However, RJ group showed a salient recovery in the all of the above mentioned parameters and embryo toxicity. Conclusion The results of this study indicated a partially protective effect of RJ against OXM-induced embryo toxicity. PMID:26464831

  3. Monitoring the Solar Radius from the Royal Observatory of the Spanish Navy since 1773

    NASA Astrophysics Data System (ADS)

    Vaquero, J. M.; Gallego, M. C.; Ruiz-Lorenzo, J. J.; López-Moratalla, T.; Carrasco, V. M. S.; Aparicio, A. J. P.; González-González, F. J.; Hernández-García, E.

    2016-08-01

    The solar diameter has been monitored at the Royal Observatory of the Spanish Navy (today the Real Instituto y Observatorio de la Armada: ROA) almost continuously since its creation in 1753 ( i.e. during the past 250 years). After a painstaking effort to collect data in the historical archive of this institution, we present here the data of the solar semidiameter from 1773 to 2006, making up an extensive new database for solar-radius measurements, which can be considered. We have calculated the solar semidiameter from the transit times registered by the observers (except for values of the solar radius from the modern Danjon astrolabe, which were published by ROA). These data were analysed to reveal any significant long-term trends, but no such trends were found. Therefore, the data sample confirms the constancy of the solar diameter during the past 250 years (approximately) within instrumental and methodological limits. Moreover, no relationship between solar radius and the new sunspot-number index has been found from measurements of the ROA. Finally, the mean value for the solar semidiameter (with one standard deviation) calculated from the observations made in the ROA (1773 - 2006), after applying corrections for refraction and diffraction, is equal to 958.87^''±1.77^''.

  4. New clinical trials regulation in Spain: analysis of royal decree 1090/2015.

    PubMed

    Martin Jimenez, M; Calvo Ferrandiz, A; Aparicio Urtasun, J; Garcia-Campelo, R; Gonzalez-Flores, E; Lazaro Quintela, M; Muñoz Mateu, M; Rodriguez Sanchez, C A; Santaballa Bertran, A; Sepulveda Sanchez, J M; Vera Garcia, R; Virizuela Echaburu, J A; Segui Palmer, M A

    2017-03-01

    The coming into force of Directive 2001/20/EC represented a step forward in harmonising clinical trial regulation in European countries, guaranteeing a uniform protection of subjects participating in clinical research across Europe. However, it led to a disproportionate increase in the bureaucratization, and thus, it became evident that procedures needed to be simplified without detriment to patient's safety. Thus, Regulation 536/2014, that repealed Directive 2001/20/EC, with the aim of decreasing the growing bureaucratization and stimulating clinical research in Europe, established simplified procedures, such as regulating a common procedure for authorising trials in Europe, the institution of strict assessment timelines, or the definition of new concepts, such as "low-intervention clinical trial". The legal form of a Regulation allowed the norm to be directly applied to Member States without the need for transposition. By means of the new Royal Decree, the national legislation is adapted to make the application of the regulation feasible and it allows the development of the aspects that the Regulation leaves to national legislation. Both documents seek to stimulate clinical research with medicinal products to foster knowledge, facilitate transparency, and reinforce subjects' safety. This will surely be the case, but with this revision, we will look at the novelties and key aspects that are most relevant to investigators and we will analyse the consequences for all parties involved in clinical research.

  5. CONFERENCE NOTE: International Workshop on Radiation Thermometry Noordwijkerhout, the Netherlands, 24 25 June 1993

    NASA Astrophysics Data System (ADS)

    1993-01-01

    Radiation thermometry is applied in the measurement of temperature where direct contact with the object is impossible, such as in the case of very high temperatures or moving bodies. Important industrial applications are metal, glass, ceramics and plastics and, latterly, semiconductor technology. Recent developments, such as multi-wavelength pyrometry, have motivated the Nederlands Meetinstituut and two Russian institutes, Energotechnica and Symco Association, to organize this workshop. Specialists from Russia, the USA, the UK, Germany and the Netherlands will present state-of-the-art practical applications in radiation thermometry. The workshop will be held on 24 and 25 June 1993 in the "Leeuwenhorst" Congress Centre, Noordwijkerhout, the Netherlands. Information on the technical contents of the programme can be obtained from Dr P Bloembergen, Tel. +31(15) 691 660. Registration For further details please contact: The Training and Consultancy Department, Nederlands Meetinstituut, PO Box 654, 2600 AR Delft, the Netherlands Tel. +31 (15) 691 567.

  6. [Two cases of royal jelly allergy provoked the symptoms at the time of their first intake].

    PubMed

    Harada, Susumu; Moriyama, Tatsuya; Tanaka, Akira

    2011-06-01

    Two young women were suffered from several symptoms after the intake of royal jelly at their first time. According to the positive skin prick test reactions of raw royal jelly, royal jelly allergy was diagnosed. As the reasons why the symptoms appeared at the time of their first intake, we guessed the possibility that 1) they had been sensitized for royal jelly formerly, or 2) their symptoms were induced by the cross-reactivity between royal jelly and other allergens such as bee, honey and pollens. As to our cases, no related allergens were found in one case, but in another case co-existence of mugwort allergy was suspected from the results of both skin prick test and specific IgE titers. Originally royal jelly allergy has been regarded as class 1 allergic reaction developed by the sensitization of itself. But we speculated the possibility that there can also be cases of class 2 royal jelly allergy by the mechanism of cross-reaction with pollens.

  7. Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.

    PubMed

    Miyashita, Atsushi; Kizaki, Hayato; Sekimizu, Kazuhisa; Kaito, Chikara

    2016-06-15

    Honeybee royal jelly is reported to have body-enlarging effects in holometabolous insects such as the honeybee, fly and silkmoth, but its effect in non-holometabolous insect species has not yet been examined. The present study confirmed the body-enlarging effect in silkmoths fed an artificial diet instead of mulberry leaves used in the previous literature. Administration of honeybee royal jelly to silkmoth from early larval stage increased the size of female pupae and adult moths, but not larvae (at the late larval stage) or male pupae. We further examined the body-enlarging effect of royal jelly in a non-holometabolous species, the two-spotted cricket Gryllus bimaculatus, which belongs to the evolutionarily primitive group Polyneoptera. Administration of royal jelly to G. bimaculatus from its early nymph stage enlarged both males and females at the mid-nymph and adult stages. In the cricket, the body parts were uniformly enlarged in both males and females; whereas the enlarged female silkmoths had swollen abdomens. Administration of royal jelly increased the number, but not the size, of eggs loaded in the abdomen of silkmoth females. In addition, fat body cells were enlarged by royal jelly in the silkmoth, but not in the cricket. These findings suggest that the body-enlarging effect of royal jelly is common in non-holometabolous species, G. bimaculatus, but it acts in a different manner than in holometabolous species.

  8. Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats

    PubMed Central

    Azab, Khaled Shaaban; Bashandy, Mohamed; Salem, Mahmoud; Ahmed, Osama; Tawfik, Zaki; Helal, Hamed

    2011-01-01

    Background: Royal jelly is a nutritive secretion produced by the worker bees, rich in proteins, carbohydrates, vitamins and minerals. Aim: The present study was designed to determine the possible protective effects of royal jelly against radiation induced oxidative stress, hematological, biochemical and histological alterations in male Wister albino rats. Materials and Methods: Male Wister albino rats were exposed to a fractionated dose of gamma radiation (2 Gy every 3 days up to 8 Gy total doses). Royal jelly was administrated (g/Kg/day) by gavages 14 days before exposure to the 1st radiation fraction and the treatment was continued for 15 days after the 1st irradiation fraction till the end of the experiment. The rats were sacrificed 3rd, equivalent to 3rd post 2nd irradiation fraction, and equivalent to 3rd day post last irradiation fraction. Results: In the present study, gamma- irradiation induced hematological, biochemical and histological effects in male Wister albino rats. In royal jelly treated irradiated group, there was a noticeable decrease recorded in thiobarbituric reactive substances concentration when compared to γ-irradiated group. Also, the serum nitric oxide concentration was significantly improved. The administration of royal jelly to irradiated rats according to the current experimental design significantly ameliorates the changes induced in serum lipid profile. Moreover, in royal jelly treated irradiated group, there was a noticeable amelioration recorded in all hematological parameters along the three experimental intervals. The microscopic examination of cardiac muscle of royal jelly treated irradiated rats demonstrated structural amelioration, improved nuclei and normal features of capillaries and veins in endomysium when compared to gamma-irradiated rats. Conclusion: It was suggested that the biochemical, hematological and histological amelioration observed in royal jelly (g/Kg/day) treated irradiated rats might be due to the antioxidant

  9. Traditional virtues, feudal ties and Royal Guards: the culture of service in the eighteenth-century "Maison Militaire du Roi".

    PubMed

    O'Brien, David C

    2003-01-01

    Recent discussions of French army reform before the Revolution have revived interest in the more general topic of military culture in the ancien régime. One account of this period speaks of an evolution in criteria for military merit, one in which professional efficiency came to overshadow traditional martial virtues, such as fidelity and courage. But a review of the evidence, both archival and published, from the Maison militaire du Roi reveals that here, at least, old virtues continued to be central until the end, serving as expressions of a relationship with the king in which royal grâces were their natural complement. Viewed historically, this conception of service continued a feudal tradition. The milieu of the Maison was distinctive in the encouragement it gave to such traditions, but the function of the institution as a pépinière of officers for the army gave it a potentially wide influence in balancing the tendencies towards professionalism.

  10. Proteomic characterization of royal jelly proteins in Chinese (Apis cerana cerana) and European (Apis mellifera) honeybees.

    PubMed

    Qu, Ning; Jiang, Jie; Sun, Liangxian; Lai, Changcheng; Sun, Lifang; Wu, Xueji

    2008-06-01

    In this study, the proteins contained in royal jelly (RJ) derived from Chinese and European honeybees have been analyzed in detail and compared. Remarkable differences were found in the heterogeneity of major royal jelly proteins (MRJPs), MRJP2 and MRJP3, in terms of molecular weight and isoelectric points between the two species of RJ. MRJP2 and MRJP3 produced by Chinese honeybee are less polymorphic than those produced by European honeybee. This study is a contribution to the description of the royal jelly proteome.

  11. Surgical training in the Netherlands.

    PubMed

    Borel-Rinkes, Inne H M; Gouma, Dirk J; Hamming, Jaap F

    2008-10-01

    Surgical training in the Netherlands has traditionally been characterized by learning on the job under the classic master-trainee doctrine. Over the past decades, it has become regionally organized with intensive structural training courses, and a peer-based quality control system. Recently, the nationwide programme has been modernized further and now involves a systematic, competency-based education with structural training courses, formalized assessment and room for reflection by residents under the supervision of surgical teaching groups. To this end, a uniform web-based digital portfolio is being introduced to facilitate monitoring of the individual resident's progress. Though requiring inspirational leadership, commitment, and determination, this modernization has sparked enthusiasm among trainees and teachers.

  12. BOOK REVIEW: Robert Hooke and the Royal Society

    NASA Astrophysics Data System (ADS)

    Brown, Neil

    2000-01-01

    Many physics students only come across Hooke when they learn his law of stretching springs, which is a pity because it is just one of his contributions to progress in science, and a minor one at that. His, Micrographia, the first great book of microscopical observations, arouses admiration to this day. He was also active in horology, astronomy, geology and surveying, and he took part in biological experiments, transfusing blood between animals. Much of his work was done while he was curator of experiments for the Royal Society, in which he was involved almost from its foundation. This was by no means a full-time occupation, however. After the Great Fire of London, Hooke was appointed one of the three surveyors for the rebuilding of the city. One of the others was Christopher Wren, a lifelong friend. In this role Hooke was responsible for the design of several buildings, including the Monument. Nichols writes about all these activities, as well as Hooke's childhood, his education at Westminster School, the University of Oxford when Hooke was an undergraduate, and the founding of the Royal Society. The book draws on research for a master's degree. Turning a dissertation into a popular book is risky. The author has avoided the pitfall of making it too academic, but the result is not satisfying. Nichols seems overawed by Hooke and his work, frequently seeming to credit Hooke with a far-reaching influence that he did not necessarily have. There may be a case for lauding Hooke as the father of English microscopy, the father of English meteorology, and the founder of English geology and earth sciences, but it needs to be made much more critically, even in a popular work. Hooke was full of good ideas, but he rarely continued long enough to put them into practice. There is no doubt that Hooke proposed using a balance wheel and spring to improve the timekeeping of a watch, for example, but he did not have a watch made to his design until after Christiaan Huygens had

  13. The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy.

    PubMed

    Erdem, Ozden; Güngörmüş, Zeynep

    2014-01-01

    This study was conducted to evaluate the effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. The study population consisted of 103 patients undergoing radiotherapy and chemotherapy. Oral mucositis was graded according to the World Health Organization criteria, and patients were divided into 2 groups. All patients received mouthwash therapy with benzydamine hydrochloride and nystatin rinses. In addition, patients in the experimental group received royal jelly. The mean resolution time of oral mucositis in the royal jelly group was significantly shorter than that of the control group. As a result, the study results demonstrate that royal jelly administrated by a certain procedure improved the signs and symptoms of oral mucositis and markedly shortened its healing time.

  14. Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression.

    PubMed

    Han, Sang Mi; Yeo, Joo Hong; Cho, Yoon Hee; Pak, Sok Cheon

    2011-01-01

    For cosmetic reasons, the demand for effective and safe skin-whitening agents is high. Since the key enzyme in the melanin synthetic pathway is tyrosinase, many depigmenting agents in the treatment of hyperpigmentation act as tyrosinase inhibitors. In this study, we have investigated the hypo-pigmentary mechanism of royal jelly in a mouse melanocyte cell line, B16F1. Treatment of B16F1 cells with royal jelly markedly inhibited melanin biosynthesis in a dose-dependent manner. Decreased melanin content occurred through the decrease of tyrosinase activity. The mRNA levels of tyrosinase were also reduced by royal jelly. These results suggest that royal jelly reduces melanin synthesis by down-regulation of tyrosinase mRNA transcription and serves as a new candidate in the design of new skin-whitening or therapeutic agents.

  15. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

    PubMed

    Spannhoff, Astrid; Kim, Yong Kee; Raynal, Noel J-M; Gharibyan, Vazganush; Su, Ming-Bo; Zhou, Yue-Yang; Li, Jia; Castellano, Sabrina; Sbardella, Gianluca; Issa, Jean-Pierre J; Bedford, Mark T

    2011-03-01

    Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly.

  16. LASERS IN THE UK, PART I: THE ROYAL RADAR ESTABLISHMENT (RRE), GREAT MALVERN, WORCESTERSHIRE.

    DTIC Science & Technology

    Solid state laser research and development at the Royal Radar Establishment is described. Particular attention is devoted to new crystalline ... materials . Measurement of photon density fluctuation in coherent source is also reported. (Author)

  17. Genetic variability among lake whitefish from Isle Royale and the Upper Great Lakes

    USGS Publications Warehouse

    Stott, Wendylee; Todd, Thomas N.; Kallemeyn, Larry

    2004-01-01

    The coregonine fishes from Isle Royale National Park represent a unique group that has escaped the successional changes observed elsewhere in North America. Analysis of microsatellite DNA loci revealed significant genetic differences among samples of lake whitefish (Coregonus clupeaformis) from Isle Royale, Lake Superior, and Lake Huron. The amount of genetic variation observed is consistent with that seen in other studies of whitefishes from North America. The lake whitefish from Isle Royale had previously been assigned sub-species status, but no evidence was found to support this. The effects of common ancestry and demographics both play a role in determining the relatedness of the populations. As with other fish species from Isle Royale and the upper Great Lakes, the lake whitefish have their origins in the Mississippi refugium.

  18. Doctor William Gunn (1804-1890): From the South Pacific Islands to Chatham Royal Dockyard.

    PubMed

    Biddle, Richard

    2016-11-24

    Doctor William Gunn had a long and varied career in the Royal Navy. After spending time on anti-slavery patrols along the west coast of Africa, he was posted to the south Pacific. At Pitcairn Island, he treated the inhabitants during an influenza epidemic, proving himself to be a determined and dedicated practitioner. Subsequently, he was appointed head of the medical department at Chatham Royal Dockyard (1859-1865), an appointment that coincided with the final stages of the Royal Navy's transition from sail and wood to steam and iron. The impact of these changes on the health of dockworkers was quickly felt at Chatham, and Gunn found himself in charge during the building of the first iron warship in a royal dockyard. His story thus offers a window through which to observe a practitioner confronting the health issues and medical uncertainties thrown up by technological change in the Victorian era.

  19. 'Any style but gothic': Building a home for the Royal College of Physicians of Ireland.

    PubMed

    Wheelock, H

    2016-06-01

    On 15 July 1864 the Royal College of Physicians of Ireland held its first business meeting in its newly built home at 6 Kildare Street, Dublin. Although the Royal College of Physicians of Ireland had been in existence for over 200 years this was the first occasion that a College meeting had been held in a building owned by the College. This paper looks at the history behind the construction of a home for the Royal College of Physicians of Ireland. It will examine why it took over 200 years for the Physicians to find a permanent home, how they ended up with the building they did, and what they borrowed from the Royal College of Physicians in Edinburgh in the process.

  20. At the Crossroads of Cyber Warfare: Signposts for the Royal Australian Air Force

    DTIC Science & Technology

    2011-06-01

    At the Crossroads of Cyber Warfare : Signposts for the Royal Australian Air Force by Craig Stallard, Squadron leader, Royal...in the conduct of cyber warfare . The 2009 Defence White Paper provided some clarity by indentifying cyber warfare as critical to the maintenance...of national security, but left open the most important issue: should cyber warfare be a joint engagement or a service oriented fight? The RAAF

  1. Experiential Education, Outdoor Adventure As a Modality in Youth Care and Residential Treatment. A Survey of Programs, Principles, Research and Practice on the European Continent, Especially the Netherlands.

    ERIC Educational Resources Information Center

    Duindam, Ton

    Orthopedagogisch Centrum Michiel is a multifunctional institution in the eastern Netherlands for youth with emotional problems. The staff of the institution's residential treatment center has gradually become involved with outdoor experiential education through training programs, conferences, special projects, and supervised programs. Activities…

  2. Royal Jelly Increases Collagen Production in Rat Skin After Ovariectomy

    PubMed Central

    Park, Hye Min; Cho, Min Hyoung; Cho, Yunhi

    2012-01-01

    Abstract Royal jelly (RJ) is a honeybee product that contains proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. RJ has been reported to have antitumor, antibacterial, and wound-healing activities. We previously reported that RJ enhanced the migration of human dermal fibroblasts and altered the levels of cholesterol and sphinganine in an in vitro wound-healing model in addition to regulating skin photoaging following exposure to ultraviolet-B radiation. We established an animal model of skin aging in the context of estrogen deficiency and assessed the antiaging effects of RJ on skin. To establish an in vivo model of skin aging, bilateral ovariectomies were performed in 12-week-old virgin female Sprague-Dawley rats. Induction of osteoporosis was confirmed through two-dimensional images of the trabecular bone in the left femoral necks using microcomputed tomography. The protective effects of RJ ovariectomy-induced skin aging were examined by determining the protein expression of type I procollagen and matrix metalloproteinase (MMP)-1. The collagen content and epidermal thickness of skin tissue were measured by staining techniques. There was a significant difference in weight between sham-operated and ovariectomized groups. Food efficiency ratio did not differ significantly among the groups. The level of procollagen type I protein was increased in the dorsal skin of ovariectomized rats fed with a dietary supplement containing 1% RJ extract, but the level of MMP-1 was not altered. In particular, the amount of collagen recovered was close to the normal level. RJ may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency. PMID:22468645

  3. Educational Innovation between Freedom and Fixation: The Cultural-Political Construction of Innovations in Early Childhood Education in the Netherlands

    ERIC Educational Resources Information Center

    van Oers, Bert

    2013-01-01

    As in many countries, in the Netherlands, governmental policy regulates the decisions of schools and care providers that concern and the control of the quality of education and care. Article 23 of the Dutch Constitution defines a fundamental right of freedom in matters of education within the context of institutions such as schools and other…

  4. Compliance of ENT emergency surgery with the Royal College of Surgeons standards

    PubMed Central

    Sharma, S; Yao, A; Mahalingam, S; Persaud, R

    2016-01-01

    Introduction In 2011 The Royal College of Surgeons of England (RCS) set out best practice standards for emergency surgery. This national pilot audit aimed to determine the compliance of otolaryngology departments in England with these published guidelines. Methods A 26-item online questionnaire was devised that encompassed all the 36 best practices as set out by the RCS for ear, nose and throat (ENT) surgery. This was sent to ENT trainees and consultants based at units in England providing emergency ENT services. Results Data were obtained from 55 of the 102 units (response rate: 54%). A mean compliance of 71% was achieved (range: 25–94%). No units achieved all of the best practices. The standards with the highest compliance included 24-hour availability of blood transfusion and haematology opinion for patients with epistaxis, availability of a consultant or ST3/equivalent for immediate discussion of severe post-tonsillectomy bleeding, 24-hour access to blood transfusion for arrest of haemorrhage and immediate theatre access for arrest of haemorrhage. The areas with the lowest compliance were provision of a pathway for angiography/embolisation for epistaxis and provision of an equipped ENT room on a paediatric ward. Conclusions This audit has highlighted that the majority of departments in England are providing a good standard of ENT emergency care. There is room for improvement in certain areas, such as the provision of an embolisation pathway in the context of refractory epistaxis. We hope that this audit will encourage ENT departments to evaluate their current provision of emergency care and institute changes (where necessary) to maintain and improve their practices. PMID:26688399

  5. Plasma medicine in the Netherlands

    NASA Astrophysics Data System (ADS)

    Kroesen, Gerrit

    2012-10-01

    Eindhoven, the Netherlands was one of the locations were Plasma Medicine originated: Eva Stoffels was one of the founders of the field. Since then, the attention for the field steadily increased. Nowadays, strong collaborations exist between the Eindhoven University of Technology (TU/e) and the Red Cross Burn Wound Hospital in Beverwijk, the Amsterdam Medical Center, the Maxima Medical Center in Eindhoven, the Radboud University in Nijmegen, the Free University in Amsterdam, and also companies, both large industries (Philips) and SME's (Vabrema, Lavoisier, Plastech). At TU/e we focus on the plasma itself: developing real time non-invasive diagnostics like TALIF, LIF, IF absorption, Thomson, Rayleigh and Raman scattering, mass spectroscopy, etc, while at the same time developing numerical models on the MD2D platform. For the biology, microbiology and medical aspects we rely on our colleagues who have specialized in those areas. Lesions that are studied are burn wounds, permanent inflammations, diabetic feet, skin infections, and internal diseases like Crohn's disease.

  6. Generic task-related occupational requirements for Royal Naval personnel.

    PubMed

    Bilzon, J L J; Scarpello, E G; Bilzon, E; Allsopp, A J

    2002-12-01

    Physical tests and selection criteria have historically been used by many military organizations. However, the standards associated with them have come under increasing scrutiny in recent years. This paper describes a series of experiments that were conducted to establish task-related occupational tests and standards (TBTs) for Royal Naval (RN) personnel. A total of 172 (106 male and 66 female) RN personnel volunteered for these experiments, which were designed to: identify the anthropometric requirements for operating various safety hatches and doors on board a RN Frigate (TBT1); quantify the metabolic demands of shipboard firefighting tasks and establish an aerobic fitness standard (TBT2); and identify a battery of tests to predict performance of shipboard casualty-carrying tasks (TBT3). Whilst all subjects completed the criterion tasks during TBT1, performance of the bulkhead door (BD) escape task was related to height (r = 0.50- 0.62, P < 0.05) and vertical reach (r = 0.42-0.54, P < 0.05), with shorter subjects struggling to perform the task. During TBT2, the mean metabolic demand of representative firefighting tasks was 38 ml/min/kg, which must be sustained for 20-30 min. Finally, a battery of tests incorporating measures of lean body mass, fat mass, standing broad jump, 20 m sprint, press-ups, sit-ups and grip strength produced a high correlation (r = 0.89, P < 0.01) with casualty-carrying task performance. From the results of these experiments, it is recommended that RN personnel perform the BD simulation task at the recruitment stage (TBT1), to prove that they possess the anthropometric characteristics commensurate with survival at sea. Secondly, personnel should be frequently screened to ascertain whether they have the maximal aerobic power (41 ml/min/kg) commensurate with shipboard firefighting for 20-30 min (TBT2). Finally, they should perform the battery of proposed tests and score at least 34 points, in order to establish whether they have the

  7. [Tropical veterinary medicine and education in The Netherlands].

    PubMed

    Uilenberg, Gerrit

    2008-01-01

    in this lecture an overview is given of the development of tropical veterinary medicine and education in The Netherlands after the Dutch colonial period. The starting point is the development of tropical veterinary medicine in general, especially in Europe and Africa. It is pointed out that just now it is very important to have specialists in tropical diseases not only in the tropics but also in the western world since globalization involves the import of a lot of tropical diseases. The speaker is an advocate of a course on tropical veterinary medicine on an European level, but at the same time he is sceptical about it. In the second part he gives an overview of the education programme on tropical veterinary medicine from the foundation of the Institute at Utrecht University in 1948 until its decline.

  8. Euthanasia in Belgium, the Netherlands and Luxembourg.

    PubMed

    2013-11-01

    Each of the Benelux countries (Belgium, Luxembourg, Netherlands) has enacted legislation that partially decriminalises euthanasia, defined as an act that intentionally terminates someone's life at their request. In the Netherlands and Luxembourg, but not in Belgium, the legislation partially decriminalised assisted suicide at the same time. In all three countries, euthanasia can only be performed by a doctor, in response to the patient's voluntary and well-considered request, and for patients who have an incurable disease that causes unbearable suffering, without any prospect of relief. In the Netherlands, minors can request euthanasia as of the age of 12 years. In 2011, reported euthanasia accounted for about 1% of deaths in Belgium and 3% in the Netherlands. In 75% of cases, cancer was the disease leading to a request for euthanasia. In the Netherlands, the number of cases of euthanasia reported by doctors in surveys matches the number that is officially declared. In Belgium, it is thought that there are as many unreported as reported cases of euthanasia. Since the enactment of euthanasia legislation, fewer deaths involve the intentional administration of lethal drugs without an explicit request from the patient.

  9. The absolute configurations of hydroxy fatty acids from the royal jelly of honeybees (Apis mellifera).

    PubMed

    Kodai, Tetsuya; Nakatani, Takafumi; Noda, Naoki

    2011-03-01

    9-Hydroxy-2E-decenoic acid (9-HDA) is a precursor of the queen-produced substance, 9-oxo-2E-decenoic acid (9-ODA), which has various important functions and roles for caste maintenance in honeybee colonies (Apis mellifera). 9-HDA in royal jelly is considered to be a metabolite of 9-ODA produced by worker bees, and it is fed back to the queen who then transforms it into 9-ODA. Recently we found that 9-HDA is present in royal jelly as a mixture of optical isomers (R:S, 2:1). The finding leads us to suspect that chiral fatty acids in royal jelly are precursors of semiochemicals. Rather than looking for semiochemicals in the mandibular glands of the queen bee, this study involves the search for precursors of pheromones from large quantities of royal jelly. Seven chiral hydroxy fatty acids, 9,10-dihydroxy-2E-decenoic, 4,10-dihydroxy-2E-decenoic, 4,9-dihydroxy-2E-decenoic, 3-hydroxydecanoic, 3,9-dihydroxydecanoic, 3,11-dihydroxydodecanoic, and 3,10-dihydroxydecanoic acids were isolated. The absolute configurations of these acids were determined using the modified Mosher's method, and it was revealed that, similar to 9-HDA, five acids are present in royal jelly as mixtures of optical isomers.

  10. Influence of royal jelly on the reproductive function of puberty male rats.

    PubMed

    Yang, Anshu; Zhou, Ming; Zhang, Li; Xie, Guoxiu; Chen, Hongbing; Liu, Zhiyong; Ma, Wei

    2012-06-01

    The adverse effects of royal jelly on the reproductive system of puberty male rats were investigated. Royal jelly was daily administered by gavage to Sprague-Dawley rats at doses 200, 400, and 800 mg/kg for 4 weeks. The body weight and organ coefficients were determined. Sperm count, spermatozoa abnormality, and testicular histopathology were examined through light microscopy. Radioimmunoassay was used to detect serum hormones. The dietary exposure to royal jelly did not affect body weight, but the organ coefficients for the pituitary and testis in the high-dose group were decreased significantly compared with the control group, and significant changes in the microstructure of the testis were observed. No significant differences in sperm count were observed among all groups, however, the sperm deformity rate in the high-dose group increased significantly. Serum hormones in the high-dose group were significantly different from the control group. After royal jelly was stopped for 14 days, the adverse changes were partially reversed and returned to levels close to those in the control group. In conclusion, high-dose royal jelly oral administration for 4 weeks adversely affected the reproductive system of pubescent male rats, but the unfavorable effects are alleviated to some extent by cessation of administration.

  11. Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats.

    PubMed

    Ibrahim, Abdelazim; Eldaim, Mabrouk A Abd; Abdel-Daim, Mohamed M

    2016-08-01

    Cisplatin is one of the most potent and effective chemotherapeutic agents. However, its antineoplastic use is limited due to its cumulative nephrotoxic side effects. Therefore, the present study was undertaken to examine the nephroprotective potential of dietary bee honey and royal jelly against subchronic cisplatin toxicity in rats. Male Wistar rats were randomly divided into controls, cisplatin-treated, bee honey-pretreated cisplatin-treated and royal jelly-pretreated cisplatin-treated groups. Bee honey and royal jelly were given orally at doses of 20 and 100 mg/kg, respectively. Subchronic toxicity was induced by cisplatin (1 mg/kg bw, ip), twice weekly for 10 weeks. Cisplatin treated animals revealed a significant increase in serum level of renal injury products (urea, creatinine and uric acid). Histopathologically, cisplatin produced pronounced tubulointerstitial injuries, upregulated the fibrogenic factors, α-smooth muscle actin (α-SMA) and transforming growth factor β1(TGF-β1), and downregulated the cell proliferation marker, bromodeoxyuridine (Brdu). Dietary bee honey and royal jelly normalized the elevated serum renal injury product biomarkers, improved the histopathologic changes, reduced the expression of α-SMA and TGF-β1 and increased the expression of Brdu. Therefore, it could be concluded that bee honey, and royal jelly could be used as dietary preventive natural products against subchronic cisplatin-induced renal injury.

  12. Effects of Royal Jelly Supplementation on Body Weight and Dietary Intake in Type 2 Diabetic Females

    PubMed Central

    Pourmoradian, Samira; Mahdavi, Reza; Mobasseri, Majid; Faramarzi, Elnaz; Mobasseri, Mehrnoosh

    2012-01-01

    Background: The objective of the current study was to assess the effects of royal jelly supple-mentation on body weight, total daily energy and macronutrients intakes in type2 diabetic fe-males. Methods: In this randomized clinical trial, fifty female volunteers with type2 diabetes were as-signed into the supplemented (n=25) and placebo (n=25) groups, given a daily dose of 1000 mg royal jelly soft gel or placebo, for 8 weeks, respectively. Before and after the intervention, body weight and height of subjects were measured and body mass index was calculated. Dietary intake of patients was assessed using 24-hour food recall questionnaire for three non consecutive days (including 1 weekend day) and analyzed with Nutritionist IV software. The normally distributed data were compared using paired and independent t-tests, where appropriate. Results: Royal jelly supplementation significantly (P<0.01) decreased the mean body weight (72.45±4.42 vs. 71.00±6.44 kg) while it increased insignificantly in placebo group (73.02±6.44 vs 73.52±6.80 kg). Royal jelly supplementation resulted in significant decrease of mean daily total energy (P<0.01) and carbohydrate (P<0.01) intakes, while in placebo group the mean daily total energy and fat intakes were increased significantly (P<0.05). Conclusion: Supplementation with royal jelly may be beneficial in weight management of di-abetic patients. PMID:24688939

  13. ‘Because of Poverty brought into Hospital: . . .’A Casenote-Based Analysis of the Changing Role of the Edinburgh Royal Maternity Hospital, 1850-1912

    PubMed Central

    Nuttall, Alison

    2008-01-01

    Summary Although the shift from a social to a medical function which occurred in nineteenth-century general hospitals has been explored, the occurrence of such a change in maternity hospitals has not been considered. Recent analyses of such institutions have examined particular aspects only, and thus give a somewhat static picture. This paper uses analysis of patient records (themselves an under-exploited resource) to explore the changing function of the Edinburgh Royal Maternity Hospital from a provider of shelter during childbirth to the destitute to a source of skilled medical care. It concludes that, although the Hospital had adopted the outward features of a medical institution by 1890, its casebooks suggest that its purpose only truly changed in the early twentieth century, and thus can perhaps be more appropriately linked with national anxiety regarding the health of babies and their mothers. PMID:18605328

  14. Institution Closures.

    ERIC Educational Resources Information Center

    Hayden, Mary F., Ed.; And Others

    1995-01-01

    This newsletter theme issue focuses on the need to accelerate the closing of institutions for people with mental retardation. Articles are by both current and former residents of institutions and by professionals, and include: "The Realities of Institutions" (Tia Nelis); "I Cry Out So That I Won't Go Insane" (Mary F. Hayden); "Trends in…

  15. Ageing aircraft research in the Netherlands

    NASA Technical Reports Server (NTRS)

    Dejonge, J. B.; Bartelds, G.

    1992-01-01

    The problems of aging aircraft are worldwide. Hence, international cooperative actions to overcome or prevent problems should be taken. The Federal Aviation Administration (FAA) and the Netherlands Civil Aviation Department (RLD) signed a Memorandum of Cooperation in the area of structural integrity, with specific reference to research on problems in the area of aging aircraft. Here, an overview is given of aging research that is going on in the Netherlands. The work described is done largely at the National Aerospace Laboratory; much of the research is part of the forementioned cooperative agreement.

  16. Faithful interpreters? Translation theory and practice at the early Royal Society

    PubMed Central

    Henderson, Felicity

    2013-01-01

    The early Fellows of the Royal Society received letters, papers and printed books written in several European vernaculars. In many cases a translation was needed to make these texts accessible. Translators, though, had to negotiate the Society's corporate views on language and prose style, and also prevailing contemporary theories of literary translation set out by popular poets such as John Dryden and Abraham Cowley. This article examines the translation practices of early Fellows of the Royal Society, showing that translations formed part of a set of knowledge-making processes at meetings. It also discusses the statements about translation theory found in the prefaces to printed volumes produced by or for Royal Society Fellows, arguing that although translators were aware of the requirement for a faithful translation, in fact they often modified their source texts to make them more useful for an English audience.

  17. Identifications of ancient Egyptian royal mummies from the 18th Dynasty reconsidered.

    PubMed

    Habicht, M E; Bouwman, A S; Rühli, F J

    2016-01-01

    For centuries, ancient Egyptian Royal mummies have drawn the attention both of the general public and scientists. Many royal mummies from the New Kingdom have survived. The discoveries of the bodies of these ancient rulers have always sparked much attention, yet not all identifications are clear even nowadays. This study presents a meta-analysis to demonstrate the difficulties in identifying ancient Egyptian royal mummies. Various methods and pitfalls in the identification of the Pharaohs are reassessed since new scientific methods can be used, such as ancient DNA-profiling and CT-scanning. While the ancestors of Tutankhamun have been identified, some identities are still highly controversial (e.g., the mystery of the KV-55 skeleton, recently most likely identified as the genetic father of Tutankhamun). The meta-analysis confirms the suggested identity of some mummies (e.g., Amenhotep III, Thutmosis IV, and Queen Tjye).

  18. Music Confucius Institute: Evaluating Its Approach as an Agent for International Chinese Music Dissemination

    ERIC Educational Resources Information Center

    Guo, Wei; Li, Sheng Bing

    2016-01-01

    The paper identifies the educational and presentational functions of the Confucius Institute (MCI) at the Royal Danish Academy of Music (RDAM) as its core approaches which mostly influence Chinese cultural dissemination in its host country. The MCI's utilization of the two dissemination approaches aligns with the "receiver-centered"…

  19. J.G. Crowther's War: Institutional strife at the BBC and British Council.

    PubMed

    Jones, Allan

    2016-06-01

    Science writer, historian and administrator J.G. Crowther (1899-1983) had an uneasy relationship with the BBC during the 1920s and 1930s, and was regarded with suspicion by the British security services because of his left politics. Nevertheless the Second World War saw him working for 'establishment' institutions. He was closely associated with the BBC's Overseas Service and employed by the British Council's Science Committee. Both organizations found Crowther useful because of his wide, international knowledge of science and scientists. Crowther's political views, and his international aspirations for the British Council's Science Committee, increasingly embroiled him in an institutional conflict with the Royal Society and with its president, Sir Henry Dale, who was also chairman of the British Council's Science Committee. The conflict centred on the management of international scientific relations, a matter close Crowther's heart, and to Dale's. Dale considered that the formal conduct of international scientific relations was the Royal Society's business rather than the British Council's. Crowther disagreed, and eventually resigned from the British Council Science Committee in 1946. The article expands knowledge of Crowther by drawing on archival documents to elucidate a side of his career that is only lightly touched on in his memoirs. It shows that 'Crowther's war' was also an institutional war between the Science Committee of the British Council and the Royal Society. Crowther's unhappy experience of interference by the Royal Society plausibly accounts for a retreat from his pre-war view that institutional science should plan and manage BBC science broadcasts.

  20. [In search of new paths. The self image of the Leopoldina and the Royal Society in London in its correspondence 1670-1677].

    PubMed

    Beeley, Philip; Scriba, Christoph J

    2008-01-01

    The article investigates the correspondence between members of the Academia Naturae Curiosorum and Henry Oldenburg, the secretary of the Royal Society, from 1670 until his death in 1677. In these years Oldenburg, originally a citizen of Bremen, continued to give support to fellow-countrymen such as Major and Sachs von Lewenhaimb whenever he could. But in contrast to the first ten years of the Royal Society, in which Oldenburg had often stressed differences in the character of the two scientific institutions, the future Leopoldina was able to establish a position of almost equal footing from 1670 onwards through its journal the Miscellanea curiosa medico-physica Academiae Naturae Curiosorum. This new self-confidence is reflected in the correspondence between Oldenburg and members of the first German academy. Alongside discussions on curiosities and monstrosities as well as on the topic of artificial gold, the discovery of phosphorus is a major theme of the correspondence in these later years. Oldenburg immediately recognized the importance of this German discovery and thereafter sought to obtain a sample of the substance for display to the Royal Society in London. His efforts were however fraught by various difficulties. Admittedly, Balduin early on sent a sample of his phosphorus to London, but it ultimately turned out not to be genuine. In the meantime Kunckel pretended to be the discoverer of the true phosphorus which he had seen when visiting Brand in Hamburg. When, in September 1677, Crafft eventually arrived in London with a sample of Brand's phosphorus Oldenburg had died tragically just a few days beforehand.

  1. High Royal Jelly-Producing Honeybees (Apis mellifera ligustica) (Hymenoptera: Apidae) in China.

    PubMed

    Cao, Lian-Fei; Zheng, Huo-Qing; Pirk, Christian W W; Hu, Fu-Liang; Xu, Zi-Wei

    2016-04-01

    China is the largest producer and exporter of royal jelly (RJ) in the world, supplying >90% of the global market. The high production of RJ in China is principally owing to the high RJ-producing lineage of honeybees (Apis mellifera ligustica Spinola, 1806) established by beekeepers in the 1980s. We describe the development of high royal jelly-producing honeybees and the management of this lineage today. Previous research and recent advances in the genetic characterization of this lineage, and the molecular markers and mechanisms associated with high RJ production are summarized. The gaps in our knowledge and prospects for future research are also highlighted.

  2. Captain Edmond Halley, F.R.S., Royal Navy, and the practice of navigation.

    NASA Astrophysics Data System (ADS)

    Waters, D. W.

    Edmond Halley, Fellow of the Royal Society, Astronomer Royal (1720 - 42), is rarely thought of or mentioned as a sea captain or a scientific seaman. Yet his shiphandling in the course of three voyages in command of Their Majesties' Pink Paramore (1698 - 1701) is in itself proof that his seamanship was of the highest order. Similarly, the practical innovations that he made in the arts of navigation and pilotage, in the form of printed sea charts and sailing directions, were fundamentally scientific and therefore remain relevant today.

  3. Presidential addresses of the Royal Society of Tropical Medicine and Hygiene: 1907–2013

    PubMed Central

    Hay, Simon I.; McHugh, Gerri M.

    2013-01-01

    Presidents have been required to give an inaugural address on commencing office at the Royal Society of Tropical Medicine and Hygiene (RSTMH) since its foundation in 1907. All presidential addresses were identified, sourced and assembled into an annotated bibliography. The majority of presidential addresses have been published in Transactions of the Royal Society of Tropical Medicine and Hygiene. Unpublished and in some cases ‘lost’ contributions have now been sourced where possible and archived at the RSTMH. This unique, rich and rewarding archive provides a vista into the development of the RSTMH and the discipline of tropical medicine. The archive is freely available to all. PMID:24026462

  4. Glacial and postglacial geologic history of Isle Royale National Park, Michigan

    USGS Publications Warehouse

    Huber, N. King

    1973-01-01

    Isle Royale was overridden by glacial ice during each of the four major glaciations of the Pleistocene Epoch, and each successive glaciation essentially obliterated all direct evidence of preceding glaciations on the island. In the waning phase of the last major glaciation, the Wisconsin Glaciation, the frontal ice margin retreated northward from at least the greater part of the Lake Superior basin, then readvanced into the basin during Valders time, about 11,000 years ago. We can attribute to the Valders ice the final aspect of glaciation on Isle Royale, including both erosional and depositional features. It is impossible to estimate the quantity of glacial debris or other surficial materials that might have been present on Isle Royale prior to the Valders readvance, but the readvancing ice appears to have removed most of what might have been present, as judged by the thin surficial cover on the eastern two-thirds of the island today. During the Valders retreat, a series of lakes formed in the Lake Superior basin in front of the retreating ice margin. The retreating ice opened successively lower outlets, and thus the general trend of lake elevations is downward. Distinct lake stages reflect periods of relative stability during which well- defined shoreline features developed. The ice front forming the north margin of the earlier lakes probably remained south of Isle Royale until about the time of glacial Lake Beaver Bay, when it retreated to a position straddling Isle Royale west of Lake Desor. Abundant deposits of glacial debris were left upon the newly deglaciated west end of the island, and the ice front remained stable long enough to build a complex of ice-margin deposits across the island. Shorelines formed by the glacial lake associated with this ice front are found on the western part of the island about 200 feet above present Lake Superior. Subsequent renewed and complete retreat of the ice margin from Isle Royale was rapid enough that only a minor amount

  5. Presidential addresses of the Royal Society of Tropical Medicine and Hygiene: 1907-2013.

    PubMed

    Hay, Simon I; McHugh, Gerri M

    2013-10-01

    Presidents have been required to give an inaugural address on commencing office at the Royal Society of Tropical Medicine and Hygiene (RSTMH) since its foundation in 1907. All presidential addresses were identified, sourced and assembled into an annotated bibliography. The majority of presidential addresses have been published in Transactions of the Royal Society of Tropical Medicine and Hygiene. Unpublished and in some cases 'lost' contributions have now been sourced where possible and archived at the RSTMH. This unique, rich and rewarding archive provides a vista into the development of the RSTMH and the discipline of tropical medicine. The archive is freely available to all.

  6. Islamic Primary Schools in the Netherlands

    ERIC Educational Resources Information Center

    Dronkers, Jaap

    2016-01-01

    During the last 20 years of the 20th century, Islamic primary schools were founded in the Netherlands thanks to its constitutional "freedom of education" (which allows state-funded religious schools), its voucher system (each school receives the same amount of money per pupil), and school choice by parents. This essay gives some…

  7. Education and Diversity in the Netherlands

    ERIC Educational Resources Information Center

    Leeman, Yvonne

    2008-01-01

    This article sets out the Dutch approach to the multicultural question. It focuses on how national policies, schools, teachers and teacher educators are addressing and making sense of questions of cultural and religious diversity. The article shows how the Netherlands has partly accommodated itself to greater cultural diversity through compulsory…

  8. Treponemal infections in hares in The Netherlands.

    PubMed Central

    Lumeij, J T; de Koning, J; Bosma, R B; van der Sluis, J J; Schellekens, J F

    1994-01-01

    Treponemal infections in wild European brown hares (Lepus europaeus) from The Netherlands were diagnosed by means of serological tests for human syphilis and histological demonstration of spirochetes by the Bosma-Steiner silver impregnation method in histological sections of skin lesions. The treponeme should probably be classified as "Treponema paraluisleporis." Images PMID:8150971

  9. Effective School Improvement in the Netherlands

    ERIC Educational Resources Information Center

    Sun, Hechuan; de Jong, Rob

    2007-01-01

    Purpose: The purpose of this study is to find out what kind of contextual factors that positively or negatively influence effective school improvement (ESI) in The Netherlands. Design/methodology/approach: To achieve the above-mentioned purpose, Sun's contextual level model with ten contextual factors and 48 indicators has been used to carefully…

  10. Rural Youth Culture: "Keten" in the Netherlands

    ERIC Educational Resources Information Center

    Haartsen, Tialda; Strijker, Dirk

    2010-01-01

    A remarkable present-day phenomenon in rural areas in the Netherlands is that young people, mostly males, often meet in small groups in self-built or at least self-fitted out sheds or caravans ("keten"). At first glance, these "keten" seem to be substitutes for more official entertainment sites in the relatively sparsely…

  11. Compact Geography of the Netherlands. (Third Edition).

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    This document presents information on the physical and human geography of the Netherlands. In this third revised edition, the contents have been brought up-to-date and expanded. In addition, sections on physical planning and environmental problems have been added. The booklet is intended for use by geography classroom teachers and students at…

  12. Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The antibacterial activity of royalisin, an antimicrobial peptide from the royal jelly produced by honeybees has been addressed extensively. However, its mechanism of action remains unclear. In this study, a recombinant royalisin, RAcc-royalisin from the royal jelly of Chinese honeybee Apis cerana...

  13. HIV transmission patterns among The Netherlands, Suriname, and The Netherlands Antilles: a molecular epidemiological study.

    PubMed

    Kramer, Merlijn A; Cornelissen, Marion; Paraskevis, Dimitrios; Prins, Maria; Coutinho, Roel A; van Sighem, Ard I; Sabajo, Lesley; Duits, Ashley J; Winkel, Cai N; Prins, Jan M; van der Ende, Marchina E; Kauffmann, Robert H; Op de Coul, Eline L

    2011-02-01

    We aimed to study patterns of HIV transmission among Suriname, The Netherlands Antilles, and The Netherlands. Fragments of env, gag, and pol genes of 55 HIV-infected Surinamese, Antillean, and Dutch heterosexuals living in The Netherlands and 72 HIV-infected heterosexuals living in Suriname and the Antilles were amplified and sequenced. We included 145 pol sequences of HIV-infected Surinamese, Antillean, and Dutch heterosexuals living in The Netherlands from an observational cohort. All sequences were phylogenetically analyzed by neighbor-joining. Additionally, HIV-1 mobility among ethnic groups was estimated. A phylogenetic tree of all pol sequences showed two Surinamese and three Antillean clusters of related strains, but no clustering between ethnic groups. Clusters included sequences of individuals living in Suriname and the Antilles as well as those who have migrated to The Netherlands. Similar clustering patterns were observed in env and gag. Analysis of HIV mobility among ethnic groups showed significantly lower migration between groups than expected under the hypothesis of panmixis, apart from higher HIV migration between Antilleans in The Netherlands and all other groups. Our study shows that HIV transmission mainly occurs within the ethnic group. This suggests that cultural factors could have a larger impact on HIV mobility than geographic distance.

  14. Implementing evidence-based policy in a network setting: road safety policy in the Netherlands.

    PubMed

    Bax, Charlotte; de Jong, Martin; Koppenjan, Joop

    2010-01-01

    In the early 1990s, in order to improve road safety in The Netherlands, the Institute for Road Safety Research (SWOV) developed an evidence-based "Sustainable Safety" concept. Based on this concept, Dutch road safety policy, was seen as successful and as a best practice in Europe. In The Netherlands, the policy context has now changed from a sectoral policy setting towards a fragmented network in which safety is a facet of other transport-related policies. In this contribution, it is argued that the implementation strategy underlying Sustainable Safety should be aligned with the changed context. In order to explore the adjustments needed, two perspectives of policy implementation are discussed: (1) national evidence-based policies with sectoral implementation; and (2) decentralized negotiation on transport policy in which road safety is but one aspect. We argue that the latter approach matches the characteristics of the newly evolved policy context best, and conclude with recommendations for reformulating the implementation strategy.

  15. Similar problems, different solutions: comparing refuse collection in the Netherlands and Spain.

    PubMed

    Bel, Germà; Fageda, Xavier; Dijkgraaf, Elbert; Gradus, Raymond

    2010-01-01

    Because of differences in institutional arrangements, public service markets, and national traditions regarding government intervention, local public service provision can vary greatly. In this paper we compare the procedures adopted by the local governments of The Netherlands and Spain in arranging for the provision of solid waste collection. We find that Spain faces a problem of consolidation, opting more frequently to implement policies of privatization and cooperation, at the expense of competition. By contrast, The Netherlands, which has larger municipalities on average, resorts somewhat less to privatization and cooperation, and more to competition. Both options-cooperation and competition-have their merits when striving to strike a balance between transaction costs and scale economies. The choices made in organizational reform seem to be related to several factors, among which the nature of the political system and the size of municipalities appear to be relevant.

  16. Co-Operative Problem-Solving at the Royal Docks Community School

    ERIC Educational Resources Information Center

    Martin, Ruth

    2013-01-01

    This article responds to Henry Tam's article in this issue of FORUM by exploring opportunities for co-operative problem-solving for staff and students of the Royal Docks Community School in the London Borough of Newham. Becoming a co-operative trust helped the school move out of special measures and develop a strategy of participation and…

  17. Build Your Own Particle Smasher: The Royal Society Partnership Grants Scheme

    ERIC Educational Resources Information Center

    Education in Science, 2012

    2012-01-01

    This article features the project, "Build Your Own Particle Smasher" and shares how to build a particle smasher project. A-level and AS-level students from Trinity Catholic School have built their own particle smashers, in collaboration with Nottingham Trent University, as part of The Royal Society's Partnership Grants Scheme. The…

  18. Dialogue and Community in Online Learning: Lessons from Royal Roads University

    ERIC Educational Resources Information Center

    Guilar, Joshua; Loring, Alice

    2008-01-01

    This study used a grounded theory case study to identify the theoretical areas that account for the nature and success of Royal Roads University's (RRU) learning community model. This instructional model enables RRU's mission to serve adult learners who want to further their careers through education while living and working across British…

  19. Leadership Roles and Responsibilities in Operationalizing the Royal Commission: A Special Education Perspective.

    ERIC Educational Resources Information Center

    McBride, Shirley

    1990-01-01

    The Director of Special Education for British Columbia reviews developments of the past year arising out of the Royal Commission on Education's report including specific legislative changes, changes in the role of the Special Education Branch, in the funding of education, and the fiscal framework. Eight priorities for the year ahead are…

  20. FACTORS AFFECTING ENHANCED MERCURY BIOACCUMULATION IN INLAND LAKES OF ISLE ROYALE NATIONAL PARK, USA

    EPA Science Inventory

    We investigated factors causing mercury (Hg) concentrations in northern pike to exceed the consumption advisory level in some inland lakes of Isle Royale National Park. Using Hg-clean techniques, we collected water, zooplankton, macroinvertebrates, and fishes in 1998 and 1999 fro...

  1. The William Houston Gold Medal of the Royal College of Surgeons of Edinburgh 2009.

    PubMed

    Flint, Helen E

    2010-12-01

    As part of the Membership in Orthodontics examination, candidates are required to present five treated cases. Two of the cases treated by one of the winners of the William Houston Gold Medal from the MOrth diet of the Royal College of Surgeons of Edinburgh in 2009 are described.

  2. Finding the Way: Improving Access to the Collections of the Royal Scottish Geographical Society

    ERIC Educational Resources Information Center

    Fenton, Candida

    2007-01-01

    Purpose: The purpose of this paper is to describe the Images for All digitisation project at the Royal Scottish Geographical Society, and lessons learned from it. Design/methodology/approach: This paper describes the background to the project and collections held. It focuses on the development of the project web site, the digitisation of 100…

  3. The William Houston Gold Medal of the Royal College of Surgeons of Edinburgh 2014, orthodontic cases.

    PubMed

    Almuzian, Mohammed

    2015-09-01

    The William Houston Medal is awarded to the individual achieving the highest mark at, the Membership in Orthodontics (MOrth) examination at the Royal College of Surgeons of Edinburgh. As part of the examination the candidate must submit five clinical cases. Details of two cases treated by the winning candidate are presented in this paper.

  4. APPARENT 85KRYPTON AGES OF GROUNDWATER WITHIN THE ROYAL WATERSHED, MAINE, USA

    EPA Science Inventory

    85Kr activities were determined in 264 domestic and municipal wells from 2002-2004 in the Royal watershed (361 km2), Maine. Gas extraction for 85Kr from wells was effected directly via a well-head methodology permitting efficient widespread analys...

  5. FACTORS AFFECTING ENHANCED MERCURY BIOACCUMULATION IN INLAND LAKES OF ISLE ROYALE NATIONAL PARK, USA

    EPA Science Inventory

    Recent results have shown that 6 of the 43 inland lakes of Isle Royale National Park, the largest island in Lake Superior, contain northen pike with mercury concentrations exceeding health conxumption advisory levels (> 500 ng/g ww). Standard length (550 mm) pike in advisory lake...

  6. Reflections on a Degree Initiative: The UK's Birmingham Royal Ballet Dancers Enter the University of Birmingham

    ERIC Educational Resources Information Center

    Benn, Tansin

    2003-01-01

    This paper provides an opportunity to share experiences and perceptions of the first 5 years of a degree programme for professional dancers. A partnership developed in the mid-1990s between the UK's Birmingham Royal Ballet and the University of Birmingham, Westhill (now School of Education), to provide a part-time, post-experience, flexible study…

  7. Ruptured-yolk peritonitis and organochlorine residues in a royal tern

    USGS Publications Warehouse

    Blus, L.J.; Locke, L.N.; Stafford, C.J.

    1977-01-01

    Ruptured-yolk peritonitis was responsible for the death of a royal tern. Lodgment of eggs in the oviduct was probably due to reverse peristalsis brought about by breakage of the thin-shelled eggs and secondary bacterial infection. The thin shells were apparently not related to the low levels of DDE and other organochlorine pollutants found in tissues and egg contents.

  8. Early examples of art in Scottish hospitals, 1: Edinburgh Royal Hospital for Sick Children.

    PubMed

    Park, Maureen

    2003-09-01

    The artist Phoebe Traquair was commissioned to decorate a mortuary chapel for Edinburgh's Royal Hospital for Sick Children. This article is the first of two which look at examples of art created for, and in, Scottish hospitals in the 19th century. It is suggested that the importance of Scotland's contribution to this movement is unrecognized by many of its modern-day practitioners.

  9. Fluidized bed boiler at the Royal Alexandra Hospital for Children, Camperdown.

    PubMed

    Ellis, J W

    1985-03-01

    A fluidized bed boiler has been installed at the Royal Alexandra Hospital for Children, Camperdown, N.S.W. This paper describes the reasons for developing a project to demonstrate that a fluidized bed coal fire combustor can be incorporated with a modern packaged steam boiler. The boiler and combustor are of Australian design as suitable proven designs from overseas were not available.

  10. MRJP microsatellite markers in Africanized Apis mellifera colonies selected on the basis of royal jelly production.

    PubMed

    Parpinelli, R S; Ruvolo-Takasusuki, M C C; Toledo, V A A

    2014-08-28

    It is important to select the best honeybees that produce royal jelly to identify important molecular markers, such as major royal jelly proteins (MRJPs), and hence contribute to the development of new breeding strategies to improve the production of this substance. Therefore, this study focused on evaluating the genetic variability of mrjp3, mrjp5, and mrjp8 and associated allele maintenance during the process of selective reproduction in Africanized Apis mellifera individuals, which were chosen based on royal jelly production. The three loci analyzed were polymorphic, and produced a total of 16 alleles, with 4 new alleles, which were identified at mrjp5. The effective number of alleles at mrjp3 was 3.81. The observed average heterozygosity was 0.4905, indicating a high degree of genetic variability at these loci. The elevated FIS values for mrjp3, mrjp5, and mrjp8 (0.4188, 0.1077, and 0.2847, respectively) indicate an excess of homozygotes. The selection of Africanized A. mellifera queens for royal jelly production has maintained the mrjp3 C, D, and E alleles; although, the C allele occurred at a low frequency. The heterozygosity and FIS values show that the genetic variability of the queens is decreasing at the analyzed loci, generating an excess of homozygotes. However, the large numbers of drones that fertilize the queens make it difficult to develop homozygotes at mrjp3. Mating through instrumental insemination using the drones of known genotypes is required to increase the efficiency of Africanized A. mellifera-breeding programs, and to improve the quality and efficiency of commercial royal jelly apiaries.

  11. Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody.

    PubMed

    Shen, Li-rong; Wang, Yi-ran; Zhai, Liang; Zhou, Wen-xiu; Tan, Liang-liang; Li, Mei-lu; Liu, Dan-dan; Xiao, Fa

    2015-02-01

    Major royal jelly protein 1 (MRJP1), designated apalbumin 1, has been regarded as a freshness marker of royal jelly (RJ). A MRJP1-specific peptide (IKEALPHVPIFD) identified by bioinformatics analysis of homologous members of the major royal protein family was synthesized and used to raise polyclonal anti-MRJP1 antibody (anti-SP-MRJP1 antibody). Western blot analysis showed that anti-SP-MRJP1 antibody only reacted with MRJP1 in RJ. In contrast, the previously reported antibody against recombinant MRJP1 (anti-R-MRJP1 antibody) reacted with other members of MRJP family in RJ. Enzyme-linked immunosorbent assay (ELISA) using anti-SP-MRJP1 antibody demonstrated that MRJP1 content in RJ stored at 40 °C significantly degraded by 37.3%, 55.9%, 58.0%, 60.6%, 65.7%, 72.7%, and 73.1% at 7, 14, 21, 28, 35, 42, and 49 d, respectively, when compared with MRJP1 content in fresh RJ (0 d). Optical density analysis of MRJP bands from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles demonstrated that the degradation of MRJP1, MRJP2, MRJP3, and MRJP5 in RJ was strongly and positively correlated with the period of storage (P<0.0001). Our results indicated anti-SP-MRJP1 antibody was highly specific for MRJP1, and ELISA using the antibody is a sensitive and easy-to-use method to determine the freshness and authenticity of RJ.

  12. Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody*

    PubMed Central

    Shen, Li-rong; Wang, Yi-ran; Zhai, Liang; Zhou, Wen-xiu; Tan, Liang-liang; Li, Mei-lu; Liu, Dan-dan; Xiao, Fa

    2015-01-01

    Major royal jelly protein 1 (MRJP1), designated apalbumin 1, has been regarded as a freshness marker of royal jelly (RJ). A MRJP1-specific peptide (IKEALPHVPIFD) identified by bioinformatics analysis of homologous members of the major royal protein family was synthesized and used to raise polyclonal anti-MRJP1 antibody (anti-SP-MRJP1 antibody). Western blot analysis showed that anti-SP-MRJP1 antibody only reacted with MRJP1 in RJ. In contrast, the previously reported antibody against recombinant MRJP1 (anti-R-MRJP1 antibody) reacted with other members of MRJP family in RJ. Enzyme-linked immunosorbent assay (ELISA) using anti-SP-MRJP1 antibody demonstrated that MRJP1 content in RJ stored at 40 °C significantly degraded by 37.3%, 55.9%, 58.0%, 60.6%, 65.7%, 72.7%, and 73.1% at 7, 14, 21, 28, 35, 42, and 49 d, respectively, when compared with MRJP1 content in fresh RJ (0 d). Optical density analysis of MRJP bands from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles demonstrated that the degradation of MRJP1, MRJP2, MRJP3, and MRJP5 in RJ was strongly and positively correlated with the period of storage (P<0.0001). Our results indicated anti-SP-MRJP1 antibody was highly specific for MRJP1, and ELISA using the antibody is a sensitive and easy-to-use method to determine the freshness and authenticity of RJ. PMID:25644470

  13. Simultaneous determination of seven fluoroquinolones in royal jelly by ultrasonic-assisted extraction and liquid chromatography with fluorescence detection.

    PubMed

    Zhou, Jinhui; Xue, Xiaofeng; Chen, Fang; Zhang, Jinzhen; Li, Yi; Wu, Liming; Chen, Lanzhen; Zhao, Jing

    2009-04-01

    A method for the quantitative determination of seven fluoroquinolone antibacterial agents (FQs) used in beekeeping, viz. ciprofloxacin, norfloxacin, ofloxacin, pefloxacin, danofloxacin, enrofloxacin, and difloxacin, in royal jelly samples was developed on the basis of high performance liquid chromatography with fluorescence detection. Sample preparation included deproteination, ultrasonic-assisted extraction with a mixed inorganic solution of monopotassium phosphate (KH(2)PO(4)) and ethylenediaminetetraacetic acid disodium salt (Na(2)EDTA), and clean-up on a solid-phase extraction cartridge. The extraction procedure was optimized with regard to the amount of inorganic solvent and the duration of sonication for royal jelly as a complicated matrix. Overall recoveries for FQs ranged from 85.9 to 99.1% for royal jelly with standard deviations between 2.79 and 6.27%. Limits of quantification were 2-40 ng/g for seven FQs in royal jelly. A total of 57 real royal jelly samples collected from beekeepers and supermarkets were analyzed. The three most abundant honeybee-use FQs, i. e. ofloxacin, ciprofloxacin, and norfloxacin, were determined in some royal jelly samples in concentrations ranging from 11.9 to 55.6 ng/g. Unexpectedly, however, difloxacin was found at concentrations of about 46.8 ng/g in one sample although it is rarely used in beekeeping. The presented method was successfully applied to quantify FQs in real royal jelly samples.

  14. [Climate change and health in the Netherlands].

    PubMed

    Huynen, Maud M T E; van Vliet, Arnold J H

    2009-01-01

    Climate change possibly affects public health in the Netherlands, including changes in (a) temperature-related effects, heat stress and air pollution, (b) allergies, (c) vector borne infectious disease, and (d) food- and waterborne infectious disease. Due to many prevailing uncertainties, opinions differ regarding the exact size of the expected health risks and the speed at which these might occur, as well as regarding to what degree society would need to or could adapt to these potential health effects. Thus, the gaps in our knowledge are substantial. Scientists and experts are clearly concerned about the limited amount of attention being paid to health effects of climate change in the Netherlands. In response, a proposal for a research programme 'Klimaatverandering en Gezondheid' ('Climate change and health') has been developed over the past year.

  15. Medical use of cannabis in the Netherlands.

    PubMed

    Gorter, Robert W; Butorac, Mario; Cobian, Eloy Pulido; van der Sluis, Willem

    2005-03-08

    The authors investigated the indications for cannabis prescription in the Netherlands and assessed its efficacy and side effects. A majority (64.1%) of patients reported a good or excellent effect on their symptoms. Of these patients, approximately 44% used cannabis for >/=5 months. Indications were neurologic disorders, pain, musculoskeletal disorders, and cancer anorexia/cachexia. Inhaled cannabis was perceived as more effective than oral administration. Reported side effects were generally mild.

  16. Death and the dead-house in Victorian asylums: necroscopy versus mourning at the Royal Edinburgh Asylum, c. 1832–1901

    PubMed Central

    Andrews, Jonathan

    2014-01-01

    This article examines the management and meaning of post-mortem examinations, and the spatial ordering of patients’ death, dissection and burial at the Victorian asylum, referencing a range of institutional contexts and exploiting a case study of the Royal Edinburgh Asylum. The routinizing of dissection and the development of the dead-house from a more marginal asylum sector to a lynchpin of laboratory medicine is stressed. External and internal pressure to modernize pathological research facilities is assessed alongside governmental, public and professional critiques of variable necroscopy practices. This is contextualized against wider issues and attitudes surrounding consent and funereal rituals. Onus is placed on tendencies in anatomizing insanity towards the conversion of deceased lunatics – pauper lunatics especially – into mere pathological specimens. On the other hand, significant but compromised resistance on the part of a minority of practitioners, relatives and the wider public is also identified. PMID:22701924

  17. A report from the inaugural meeting of the British Neurosurgical Trainee Research Collaborative held in the Royal College of Surgeons of England, 19 October 2012.

    PubMed

    Kolias, Angelos G; Jones, Timothy L; Cowie, Christopher J; Coulter, Ian C; Afshari, Fardad T; Tarnaris, Andrew; Nelson, Richard J; Gray, William P; Hutchinson, Peter J; Brennan, Paul M

    2013-06-01

    Clinical research, which is essential for improving patient outcomes, is increasingly carried out in the context of networks established between multiple institutions. Research is also considered an important component of training curricula. The recent successful completion of a randomised trial (ROSSINI), which was led by general surgical trainees of the West Midlands Research Collaborative, has established the feasibility of trainee collaborative research networks. A research network for neurosurgical trainees in the UK and Ireland was, therefore, established following the meeting of the British Neurosurgical Trainee Association (BNTA) in Aberdeen on 19 April 2012. This BNTA initiative quickly gained the full support from the Society of British Neurological Surgeons and the UK Neurosurgical Research Network. The inaugural meeting of the British Neurosurgical Trainee Research Collaborative took place at the Royal College of Surgeons of England, London, on 19 October 2012. The purpose of this report is both to record progress to date and to promote this concept.

  18. The End of Alchemy? The Repudiation and Persistence of Chrysopoeia at the Académie Royale des Sciences in the Eighteenth Century.

    PubMed

    Principe, Lawrence M

    2014-01-01

    The general abandonment of serious endeavor toward metallic transmutation represents a major development in the history of chemistry, yet its exact causes and timing remain unclear. This essay examines the fate of chrysopoeia at the eighteenth-century Académie Royale des Sciences. It reveals a long-standing tension between Académie chemists, who pursued transmutation, and administrators, who tried to suppress it. This tension provides background for Etienne-François Geoffroy's 1722 paper describing fraudulent practices around transmutation. Although transmutation seems to disappear after Geoffroy's paper, manuscripts reveal that most of the institution's chemists continued to pursue it privately until at least the 1760s, long after widely accepted dates for the "demise of alchemy" in learned circles.

  19. Gene therapy legislation in The Netherlands.

    PubMed

    Bleijs, D A; Haenen, I T W C; Bergmans, J E N

    2007-10-01

    Several regulatory organisations are involved in the assessment of clinical gene therapy trials involving genetically modified organisms (GMOs) in The Netherlands. Medical, ethical and scientific aspects are, for instance, evaluated by the Central Committee on Research Involving Human Subjects (CCMO). The Ministry of Housing, Spatial Planning and the Environment (VROM) is the competent authority for the environmental risk assessment according to the deliberate release Directive 2001/18/EC. A Gene Therapy Office has been established in order to streamline the different national review processes and to enable the official procedures to be completed as quickly as possible. Although the Gene Therapy Office improved the application process at the national level, there is a difference of opinion between the EU member states with respect to the EU Directive according to which gene therapy trials are assessed, that urges for harmonisation. This review summarises the gene therapy legislation in The Netherlands and in particular The Netherlands rationale to follow Directive 2001/18/EC for the environmental risk assessment.

  20. "Making a Mess in the Mud": The Discovery of Toddlers' Special Needs by Child Scientists in the 1930s in the Netherlands

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2012-01-01

    In this article, the author discusses plans that were launched at three consecutive conferences on care for toddlers between 1929 and 1938 in the Netherlands. These plans and their realisation are evaluated in terms of what was seen as the missing link in the supply of institutional care for young children. The author identifies the professional…

  1. The Impact of New Technologies on Occupational Profiles in the Banking Sector. Case Studies in Luxembourg, the Netherlands, the United Kingdom and France. CEDEFOP Panorama.

    ERIC Educational Resources Information Center

    Vitali, Laurence; Freiche, Jeanine; Matthews, Alison; Warmerdam, John

    The impact of new technologies on occupational profiles in the banking sector was examined through case studies in four European countries: Luxembourg, the Netherlands, the United Kingdom, and France. In each country, three types of banking institutions were studied: merchant (Eurobank); "counter" (universal) bank; and telebank (bank…

  2. Odontology and the history of medicine at the Royal Society of Medicine 1907-1960 and the contributions of Lilian Lindsay--Part One. The early years of the Royal Society of Medicine and the Section of Odontology.

    PubMed

    Papworth, Julie

    2014-01-01

    This paper examines the foundation of the Royal Society of Medicine and the Sections of Odontology. It considers the remarkable achievements of Lilian Lindsay which were made at a time when the medical world was almost entirely dominated by men.

  3. [Creating a 'Germanic' public health: national-socialism, human genetics, and eugenics in the Netherlands].

    PubMed

    Snelders, Stephen

    2007-01-01

    The consequences of the uses of concepts of heredity in society and health care are not simply determined. This is demonstrated by a study of Dutch National Socialist doctors and biologists in the Second World War. During the German occupation of the Netherlands SS-biologist W.F.H. Stroër (1907-1979) and SS-doctor J.A. van der Hoeven (1912-1998) attempted to create a eugenic research and health care institute in the Netherlands. Heredity was accorded a key role in National Socialist plans for reorganization of Dutch health care. The ideas of the SS-eugenicists were closely related to those of leading geneticists and eugenicists in the Netherlands. Eugenic ideas were spread among all political ideologies. As late as November 1942 cooperation between the SS and non-Nazi geneticists was still discussed. The hardening of the political climate during the war created more explicit dividing lines between them. The SS-researchers did not believe in the existence of well-defined and separated races. They rejected a purely genetic determinism and advocated measures of social hygiene next to a positive and negative eugenics in the creation of a more healthy Germanic people and a purer race. Racial and genetic concepts were not exclusively translated into eugenic policies directed at human reproduction.

  4. 75 FR 57815 - Purified Carboxymethylcellulose From Finland, Mexico, Netherlands, and Sweden

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... COMMISSION Purified Carboxymethylcellulose From Finland, Mexico, Netherlands, and Sweden AGENCY: United... antidumping duty orders on purified carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden... antidumping duty orders on purified carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden...

  5. Sir William Burnett (1779-1861), professional head of the Royal Naval Medical Department and entrepreneur.

    PubMed

    Penn, Christopher

    2004-08-01

    Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.

  6. Organochlorine and metal residues in royal terns nesting on the central Texas coast

    USGS Publications Warehouse

    King, K.A.; LeFever, C.A.; Mulhern, B.M.

    1983-01-01

    Royal Tern eggs collected from Pelican and Sundown islands on the central Texas coast in 1978 contained relatively low levels of organochlorine and metal pollutants. DDE and PCBs were found most frequently, but levels were below those known to have an adverse effect on avian reproduction and survival. Average metal residues did not vary significantly between study areas, and with the possible exception of mercury, were present only at background levels. Shells of eggs collected in 1978 were no thinner than eggshells collected before 1947. There was a significant imporvement in mean eggshell thickness from 1970 to 1978 and a corresponding decline in DDE and PCB residues. No deformed or abnormal young were observed. Although elevated levels of industrial contaminants were reported in sediments and sea grasses of Corpus Christi Bay, little of those contaminants appear to have accumulated in the Royal Tern.

  7. The zoonotic implications of pentastomiasis in the royal python (python regius).

    PubMed

    Ayinmode, Ab; Adedokun, Ao; Aina, A; Taiwo, V

    2010-09-01

    Pentastomes are worm-like endoparasites of the phylum Pentastomida found principally in the respiratory tract of reptiles, birds, and mammals. They cause a zoonotic disease known as pentastomiasis in humans and other mammals. The autopsy of a Nigerian royal python (Python regius) revealed two yellowish-white parasites in the lungs, tissue necrosis and inflammatory lesions. The parasite was confirmed to be Armillifer spp (Pentastomid); this is the first recorded case of pentastomiasis in the royal python (Python regius) in Nigeria. This report may be an alert of the possibility of on-going zoonotic transmission of pentastomiasis from snake to man, especially in the sub-urban/rural areas of Nigeria and other West African countries where people consume snake meat.

  8. Large-scale preparation of glycopeptides harboring the TF-antigen unit from royal jelly.

    PubMed

    Maeda, Megumi; Tanaka, Tatsuya; Kimura, Mariko; Kimura, Yoshinobu

    2014-01-01

    We have reported that new N-glycans carrying the TF-antigen occurred on a major royal jelly glycoprotein, and we have identified the glycosylation site to which the antigenic N-glycan is linked, but an appropriate procedure has not been established to prepare non-labeled immunoreactive glycopeptides in large amounts for functional analysis. In this study, we developed an effective method of preparing Asn-glycopeptide bearing TF-antigen.

  9. [Health care in the prisons of the Kingdom. General Royal Ordinance of prisons of 1834].

    PubMed

    Leiva-Tapia, J

    2015-01-01

    In the 19th century, the concept of "prison health" began to make an appearance in Spanish legislation as an integral part of prison management. Thanks to a series of ideological and progressive principles in the same century, laws were decreed and regulated to address the need for adequate medical care for prisoners in Africa, Spain and the overseas territories. The most important of these was the Royal Ordinance of Prisoners of the Kingdom of 1834, and subsequent Regulation of 1844.

  10. The Royal Medical Society of Edinburgh: Sale of its Library at Sotheby's *

    PubMed Central

    Crawford, Helen

    1970-01-01

    The library of the Royal Medical Society of Edinburgh, which has been in existence for nearly 250 years, was sold by Sotheby & Co. of London at three auction sales during 1969. The author describes her attendance at the three sales, with emphasis on the most valuable items sold and the considerable acquisitions made for the Middleton Medical Library of the University of Wisconsin. Concluding observations concern some of the practical problems of acquiring antiquarian books at auction. Images PMID:5496237

  11. The Role of IMAT Solutions for Training Development at the Royal Netherlands Air Force. IMAT Follow-up Research Part 1

    DTIC Science & Technology

    2005-09-01

    are prevented . 3.1.3 Organisational Memory Tool The general purpose of the organisational memory tool is to assist users in the process of creating...steps of a user in a directive manner and prevents a user from making mistakes as much as possible. The next figure gives an example of one of the steps...FunctiorWl knowledige of systerm x 8].. Being able to perform all preventive maintenance tasks• E• To perform Vap~ection tasks SDeclarative knowledge about

  12. Effect of storage under extremely low oxygen on the volatile composition of 'Royal Gala' apples.

    PubMed

    Both, Vanderlei; Brackmann, Auri; Thewes, Fabio Rodrigo; Ferreira, Daniele de Freitas; Wagner, Roger

    2014-08-01

    The aim of this work was to assess the profile of volatile compounds in 'Royal Gala' apples stored under controlled atmosphere (CA), with O(2) levels ranging from 1.0kPa to as low as 0.5kPa during 8months (0.5°C), followed by 7days of shelf-life at 20°C. Volatile compounds were collected via solid-phase microextraction (HS-SPME) and analysed by gas chromatography. Straight and branched-chain esters exhibited a distinct pattern. The emission of straight-chain esters decreased under extremely low O(2) (0.5kPa), while branched-chain esters were not significantly affected in such condition. 2-Methyl-butyl acetate, a significant contributor to the 'Royal Gala' aroma, was higher in intermediate O(2) concentration, suggesting that lowering the O(2) levels down to 0.7kPa does not negatively affect the volatile composition of 'Royal Gala' apples, as compared to the standard CA (1.0kPa O(2)). The remaining volatile compounds were not strongly affected by storing fruits under extremely low O(2).

  13. Heat Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer.

    PubMed

    Moriyama, Takanori; Ito, Aimi; Omote, Sumire; Miura, Yuri; Tsumoto, Hiroki

    2015-01-01

    Soluble royal jelly protein is a candidate factor responsible for mammiferous cell proliferation. Major royal jelly protein 1 (MRJP1), which consists of oligomeric and monomeric forms, is an abundant proliferative protein in royal jelly. We previously reported that MRJP1 oligomer has biochemical heat resistance. Therefore, in the present study, we investigated the effects of several heat treatments (56, 65 and 96°C) on the proliferative activity of MRJP1 oligomer. Heat resistance studies showed that the oligomer molecular forms were slightly maintained until 56℃, but the molecular forms were converted to macromolecular heat-aggregated MRJP1 oligomer at 65℃ and 96℃. But, the growth activity of MRJP1 oligomer treated with 96°C was slightly attenuated when compared to unheated MRJP1 oligomer. On the other hand, the cell proliferation activity was preserved until 96℃ by the cell culture analysis of Jurkat cells. In contrast, those of IEC-6 cells were not preserved even at 56°C. The present observations suggest that the bioactive heat-resistance properties were different by the origin of the cells. The cell proliferation analysis showed that MRJP1 oligomer, but not MRJP2 and MRJP3, significantly increased cell numbers, suggesting that MRJP1 oligomer is the predominant proliferation factor for mammiferous cells.

  14. Life history variation among four lake trout morphs at Isle Royale, Lake Superior

    USGS Publications Warehouse

    Hansen, Michael J.; Nate, Nancy A.; Muir, Andrew M.; Bronte, Charles R.; Zimmerman, Mara S.; Krueger, Charles C.

    2016-01-01

    Life history traits were compared among four morphs of lake trout at Isle Royale, Lake Superior. Of 738 lake trout caught at Isle Royale, 701 were assigned to a morph (119 humpers, 160 leans, 85 redfins, and 337 siscowets) using a combination of statistical analysis of head and body shape and visual assignment. On average, redfins were longer (544 mm), heavier (1,481 g), heavier at length (Wr = 94), more buoyant, and older (22 years) than siscowets (519 mm; 1,221 g; 90; 19 years), leans (479 mm; 854 g; 82; 13 years), and humpers (443 mm; 697 g; 87; 17 years). On average, leans grew from a younger age at length = 0 and shorter length at age = 0, at a faster early growth rate to a longer asymptotic length than the other three morphs, while redfins grew at a slower instantaneous rate and humpers grew to a shorter asymptotic length than other morphs. On average, leans were longer (562 mm) and older (15 years) at 50% maturity than redfins (427 mm, 12 years), siscowets (401 mm, 11 years), or humpers (394 mm, 13 years). Life history parameters did not differ between males and females within each morph. We conclude that differences in life history attributes of lean, humper, redfin, and siscowet morphs of lake trout are consistent with differential habitat use in waters around Isle Royale, Lake Superior.

  15. The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series*

    PubMed Central

    Siavash, Mansour; Shokri, Saeideh; Haghighi, Sepehr; Mohammadi, Mahbubeh; Shahtalebi, Mohammad Ali; Farajzadehgan, Ziba

    2011-01-01

    BACKGROUND: Foot ulcers and infections are the major sources of morbidity in individuals with diabetes mellitus. This study aimed to evaluate the efficacy of topical Royal Jelly (a worker honey bee product) on healing diabetic foot ulcers. METHODS: Diabetic patients with foot ulcers that were referred to our clinic at Khorshid Hospital, Isfahan, Iran; were evaluated three times a week and treated according to standard treatments consisted of offloading, infection control, vascular improvement and debridement if required. In addition, all ulcers were measured and then topical sterile 5% Royal Jelly was applied on the total surface area of the wounds. Eventually, they were covered with sterile dressings. Each patient was followed for a period of three months or until the complete healing. RESULTS: A total of eight patients were enrolled in this study. Of these, two had two ulcers and, therefore, ten ulcers were evaluated. Two ulcers were excluded. Seven of the remained eight ulcers healed. Mean duration of complete healing was 41 days. One ulcer did not completely heal but improved to 40% smaller in length, 32% in width and 28% in depth. The mean length, width and depth reduction rates were 0.35 mm/day, 0.28 mm/day and 0.11 mm/day, respectively. CONCLUSIONS: Royal Jelly dressing may be an effective method for treating diabetic foot ulcers besides standard treatments. PMID:22279458

  16. Evaluation and review of the safety management system implementation in the Royal Thai Air Force

    NASA Astrophysics Data System (ADS)

    Chaiwan, Sakkarin

    This study was designed to determine situation and effectiveness of the safety management system currently implemented in the Royal Thai Air Force. Reviewing the ICAO's SMS and the RTAF's SMS was conducted to identify similarities and differences between the two safety management systems. Later, the researcher acquired safety statistics from the RTAF Safety Center to investigate effectiveness of its safety system. The researcher also collected data to identify other factors affecting effectiveness of the safety system during conducting in-depth interviews. Findings and Conclusions: The study shows that the Royal Thai Air Force has never applied the International Civil Aviation Organization's Safety management System to its safety system. However, the RTAF's SMS and the ICAO's SMS have been developed based on the same concepts. These concepts are from Richard H. Woods's book, Aviation safety programs: A management handbook. However, the effectiveness of the Royal Thai Air Force's safety system is in good stance. An accident rate has been decreasing regularly but there are no known factors to describe the increasing rate, according to the participants' opinion. The participants have informed that there are many issues to be resolved to improve the RTAF's safety system. Those issues are cooperation among safety center's staffs, attitude toward safety of the RTAF senior commanders, and safety standards.

  17. Major royal jelly proteins as markers of authenticity and quality of honey.

    PubMed

    Bilikova, Katarina; Kristof Krakova, Tatiana; Yamaguchi, Kikuji; Yamaguchi, Yoshihisa

    2015-12-01

    Until now, the properties of honey have been defined based exclusively on the content of plant components in the nectar of given plant. We showed that apalbumin1, the major royal jelly (RJ) protein, is an authentic and regular component of honey. Apalbumin1 and other RJ proteins and peptides are responsible for the immunostimulatory properties and antibiotic activity of honey. For the quantification of apalbumin1, an enzyme-linked immunosorbent assay (ELISA) was developed using polyclonal anti-apalbumin1 antibody. The method is suitable for honey authenticity determination; moreover it is useful for detection of the honey, honeybee pollen and RJ in products of medicine, pharmacy, cosmetics, and food industry, where presences of these honeybee products are declared. Results from the analysis for presence and amount of apalbumin1 in honeys will be used for high-throughput screening of honey samples over the world. On the basis of our experiments which show that royal jelly proteins are regular and physiologically active components of honey we propose to change the definition of honey (according to the EU Honey Directive 2001/110/EC) as follows: Honey is a natural sweet substance produced by honey bees from nectar of plants or from secretions of plants, or excretions of plant sucking insects, which honey bees collect, transform by combining with major royal jelly proteins and other specific substances of their own, deposit, dehydrate, store and leave in the honey comb to ripen and mature.

  18. [Possible exposure to rabies in anamnesis: rabies advice in the Netherlands].

    PubMed

    Beaujean, D J M A; van Ouwerkerk, I M S; Timen, A; Burgmeijer, R J F; Vermeer de Bondt, P E; van Steenbergen, J E

    2008-03-01

    Anamnestic incidences of four patients have highlighted the potential risk ofexposure to rabies. The first patient was a 30-year-old woman who rescued a bat from the mouth of her dog; it bit her on the right wrist. In the Netherlands, bats may be infected with the Lyssa virus. The Preparedness and Response Unit (PRU) of the Centre for Infectious Disease Control (CIDC) advised human rabies immunoglobulin (HRIG) and a full vaccination programme. The second patient was a 37-year-old woman, who caught a 'sick' squirrel and was subsequently bitten on her left hand. The advice was not to use post exposure prophylaxis since rabies is not prevalent amongst squirrels in the Netherlands. The third patient, a 55-year-old man, was bitten on his right calf by a dog in Sri Lanka. He was treated with HRIG and given the full vaccination course. The fourth patient was a 14-month-old boy who was scratched on the face by a cat in Turkey. He immediately received the first vaccination and upon return to the Netherlands was treated with HRIG and the other vaccinations. All patients remained without symptoms. A structured approach for risk assessment of each potential rabies incident is possible. It requires balancing a number of criteria: the species of animal, the endemicity of rabies in a country, the observed health or vaccination status of an animal, whether the animal can be tested for rabies, if the exposure was provoked or unprovoked, the type of injury and its location on the body of the injured, and the time interval between administration of HRIG and vaccine. In the Netherlands all health care providers are expected to perform a proper risk assessment. They may seek advice from regional health departments (Municipal Health Services), who, in turn, can be assisted by the PRU. HRIG and vaccine are only provided by the National Vaccine Institute in Bilthoven.

  19. Institutional Censorship

    ERIC Educational Resources Information Center

    Burke, John Gordon; Bowers, H. Paxton

    1970-01-01

    The difficulty an individual who has been denied access to library material faces in obtaining a remedy in the courts dictates that the library profession go on record against all forms of institutional censorship or unreasonable restrictions on use of library materials. (Author/JS)

  20. Institutional betrayal.

    PubMed

    Smith, Carly Parnitzke; Freyd, Jennifer J

    2014-09-01

    A college freshman reports a sexual assault and is met with harassment and insensitive investigative practices leading to her suicide. Former grade school students, now grown, come forward to report childhood abuse perpetrated by clergy, coaches, and teachers--first in trickles and then in waves, exposing multiple perpetrators with decades of unfettered access to victims. Members of the armed services elect to stay quiet about sexual harassment and assault during their military service or risk their careers by speaking up. A Jewish academic struggles to find a name for the systematic destruction of his people in Nazi Germany during the Holocaust. These seemingly disparate experiences have in common trusted and powerful institutions (schools, churches, military, government) acting in ways that visit harm upon those dependent on them for safety and well-being. This is institutional betrayal. The purpose of this article is to describe psychological research that examines the role of institutions in traumatic experiences and psychological distress following these experiences. We demonstrate the ways in which institutional betrayal has been left unseen by both the individuals being betrayed as well as the field of psychology and introduce means by which to identify and address this betrayal.

  1. Institution Morphisms

    NASA Technical Reports Server (NTRS)

    Goguen, Joseph; Rosu, Grigore; Norvig, Peter (Technical Monitor)

    2001-01-01

    Institutions formalize the intuitive notion of logical system, including both syntax and semantics. A surprising number of different notions of morphisim have been suggested for forming categories with institutions as objects, and a surprising variety of names have been proposed for them. One goal of this paper is to suggest a terminology that is both uniform and informative to replace the current rather chaotic nomenclature. Another goal is to investigate the properties and interrelations of these notions. Following brief expositions of indexed categories, twisted relations, and Kan extensions, we demonstrate and then exploit the duality between institution morphisms in the original sense of Goguen and Burstall, and the 'plain maps' of Meseguer, obtaining simple uniform proofs of completeness and cocompleteness for both resulting categories; because of this duality, we prefer the name 'comorphism' over 'plain map.' We next consider 'theoroidal' morphisms and comorphisims, which generalize signatures to theories, finding that the 'maps' of Meseguer are theoroidal comorphisms, while theoroidal morphisms are a new concept. We then introduce 'forward' and 'semi-natural' morphisms, and appendices discuss institutions for hidden algebra, universal algebra, partial equational logic, and a variant of order sorted algebra supporting partiality.

  2. Exploring Political Views on Synthetic Biology in the Netherlands.

    PubMed

    Rerimassie, Virgil

    2016-01-01

    Synthetic biology may be an important source of progress as well as societal and political conflict. Against this backdrop, several technology assessment organizations have been seeking to contribute to timely societal and political opinion-making on synthetic biology. The Rathenau Instituut, based in the Netherlands, is one of these organizations. In 2011, the institute organized a 'Meeting of Young Minds': a young people's debate between 'future synthetic biologists' and 'future politicians'. The former were represented by participants in the international Genetically Engineered Machines competition (iGEM), the latter by political youth organizations (PYOs) linked to Dutch political parties. The Rathenau Instituut found seven PYOs-including right wing, left wing, Green and Christian groups-willing to commit to an intensive process aimed at formulating a tentative partisan view on synthetic biology and discussing it with fellow PYOs and iGEM participants. Given the minimal amount of available data on how political parties understand synthetic biology, mapping the debate may provide valuable insights. In this article, I aim to provide such a mapping exercise and also to reflect on how and why the Rathenau Instituut organized the event.

  3. The marginal success of regulated competition policy in the Netherlands.

    PubMed

    Lieverdink, H

    2001-04-01

    In the second half of the 1980s the government in the Netherlands adopted a regulated competition policy as part of a comprehensive programme designed to restructure the health care system. The programme was a product of its social and political context, promoted by a group of political entrepreneurs and created to improve efficiency. Despite the initial political support and a long political debate the government had to acknowledge by 1992 that the restructuring would not take place. But changes fostered limited competition between sickness funds and more extensive competition in the small market for supplementary policies. This, however, has not led to sickness funds becoming powerful purchasers that forced hospitals and doctors to improve their efficiency. Rather, they compete for subscribers, become part of large insurance conglomerates, and market more supplementary options. Culturally, health care institutions have become more entrepreneurial, taken up more business concepts, and made the language of markets, products and consumer sovereignty more common. The impact of these changes on the health care system is still unknown, but they create pressure for more health care services, leaving the government with problems that equal those of the 1980s.

  4. Saltwater movement in the upper Floridan aquifer beneath Port Royal Sound, South Carolina

    USGS Publications Warehouse

    Smith, Barry S.

    1994-01-01

    Freshwater for Hilton Head Island, South Carolina, is supplied by withdrawals from the Upper Floridan aquifer. Freshwater for the nearby city of Savannah, Georgia, and for the industry that has grown adjacent to the city, has also been supplied, in part, by withdrawal from the Upper Floridan aquifer since 1885. The withdrawal of ground water has caused water levels in the Upper Floridan aquifer to decline over a broad area, forming a cone of depression in the potentiometric surface of the aquifer centered near Savannah. In 1984, the cone of depression extended beneath Hilton Head Island as far as Port Royal Sound. Flow in the aquifer, which had previously been toward Port Royal Sound, has been reversed, and, as a result, saltwater in the aquifer beneath Port Royal Sound has begun to move toward Hilton Head Island. The Saturated-Unsaturated Transport (SUTRA) model of the U.S. Geological Survey was used for the simulation of density-dependent ground-water flow and solute transport for a vertical section of the Upper Floridan aquifer and upper confining unit beneath Hilton Head Island and Port Royal Sound. The model simulated a dynamic equilibrium between the flow of seawater and freshwater in the aquifer near the Gyben-Herzberg position estimated for the period before withdrawals began in 1885; it simulated reasonable movements of brackish water and saltwater from that position to the position determined by chemical analyses of samples withdrawn from the aquifer in 1984, and it approximated hydraulic heads measured in the aquifer in 1976 and 1984. The solute-transport simulations indicate that the transition zone would continue to move toward Hilton Head Island even if pumping ceased on the island. Increases in existing withdrawals or additional withdrawals on or near Hilton Head Island would accelerate movement of the transition zone toward the island, but reduction in withdrawals or the injection of freshwater would slow movement toward the island, according to the

  5. Energy R and D in the Netherlands

    SciTech Connect

    EEM Luiten; JJ Dooley; K Blok

    1999-09-07

    This report documents trends in R and D and in particular (public) energy R and D in the Netherlands. Besides quantitative information on R and D and energy R and D, the report gives an impression of changes in science and technology policy, energy policy and changes in energy research priorities (both organizational and financial). In the Netherlands, 2.09% of GDP (or $6.7 billion) was invested in R and D activities in 1995. The private sector financed 46% of all R and D in that year. A small but significant fraction (9.3%) of the research performed in the Netherlands is financed by foreign public and private sector entities. Energy R and D has been identified by the national Strategic Foresight Activity as an important area of R and D for government support in the future. This is due in part to the overall decline in public support for energy R and D that occurred from 1985 to 1995. However, recent concern over climate change and energy policy has resulted in increased budgets for energy R and D. Recent policy documents (e.g., the Memorandum on Energy R and D in April 1998) and initiatives (e.g., a recent university energy R and D program; intensification of climate policy, partly in R and D) indicate the growing interest in addressing the issue of climate change partly through energy R and D. The Dutch government believes that the liberalization of the energy market in the Netherlands justifies an active role for the government to guarantee the longer-term transformation to a sustainable energy system. In terms of climate policy, the expanded and more efficient use of natural gas is seen as a suitable transition option towards a sustainable energy system. However, energy efficiency (and in particular energy efficiency in the industrial sector) and the introduction of renewable technologies (solar energy, wind energy and biomass) are generally favored for the long term. Recently, additional funding was allocated for research on industrial ''breakthrough

  6. The Future of Agricultural Education: The Case of the Netherlands

    ERIC Educational Resources Information Center

    Mulder, Martin; Kupper, Hendrik

    2006-01-01

    Agricultural education has been an essential factor in the success of agricultural development in the Netherlands. At present, as in many countries throughout the world, the position of agricultural education is threatened. Does agricultural education have a future in the Netherlands, and if so, what strategies are being used for its survive? This…

  7. Young Migrants and Discourses on Young Migrants in the Netherlands

    ERIC Educational Resources Information Center

    Gerritsen, Debby; Maier, Robert

    2012-01-01

    This article compares the perspectives of young migrants in the Netherlands with the dominant discourse on "migrants" at present. The integration of young "migrants" have been studied in the European research projects TRESEGY and PROFACITY with the help of a number of ethnographic studies and a questionnaire in the Netherlands.…

  8. Innovation in the Netherlands: Toward Guidelines for Knowledge Transfer

    ERIC Educational Resources Information Center

    Stiekema, Esther I.

    2005-01-01

    When the objectives of the Lisbon Convention were formulated in 2000, the Dutch Government decided that the Netherlands should give priority to achieving these objectives. In 2010 the Netherlands should be one of the most successful economies in Europe, which should itself be the most competitive knowledge-based economic region in the world. With…

  9. The Salient History of Dalton Education in the Netherlands

    ERIC Educational Resources Information Center

    van der Ploeg, Piet

    2014-01-01

    In the Netherlands there are 400 Dalton schools, while Dalton education has all but disappeared elsewhere, including in its country of origin: the USA. Following a brief period in the 1920s in which it enjoyed strong international interest, it disappeared from the scene. How can it be that the Dalton Plan still exists only in the Netherlands? This…

  10. An evaluation of the Royal Air Force helicopter search and rescue services in Britain with reference to Royal Air Force Valley 1980-1989.

    PubMed Central

    Liskiewicz, W J

    1992-01-01

    The Royal Air Force (RAF) operates a helicopter Search and Rescue (SAR) service in the United Kingdom and territorial waters; it also provides a similar service in several locations abroad. A 10-year retrospective study of the SAR helicopter service operating from the RAF base at Valley on the island of Anglesey in North Wales is presented, with national SAR statistics over a similar period provided for comparison. Analysis of records kept by SAR aircrew at RAF Valley shows that their assistance had been requested on 1490 occasions during the 10-year period studied; most of these requests were the result of incidents involving holidaymakers, particularly in the mountains or along the coast. The results illustrate the versatility and life-saving potential of a highly skilled and motivated service able to work in adverse weather and dangerous locations. In the light of current debate, the value of aeromedical evacuation of seriously ill patients using helicopters is discussed. PMID:1494160

  11. XIXth century earthquakes in Belgium, the Netherlands and western Germany

    NASA Astrophysics Data System (ADS)

    Knuts, Elisabeth; Dost, Bernard; Alexandre, Pierre; Camelbeeck, Thierry

    2014-05-01

    Since the last quarter of the XXth century, the rules of the historic criticism are applied in the study of the past earthquakes thanks to the collaboration between seismologists and historians. Various monographs have already been published on the historic seismicity of Belgium, Netherlands and nearby regions but few about the XIXth century. The list of the shocks arisen in those regions is not clearly established. For the major earthquakes, we can find useful monographs that where published at the time of the events. However there is a lack of information about smaller earthquakes that are mentioned in the Belgian, Dutch, French and German catalogs. For those smaller events it is often not possible to determine the zone of perceptibility. Sometimes we cannot even take for sure that the reported event is a real one. The aim of our study is to overcome this gap. Taking into account the rules of historical criticism, we read all the available bibliography, undertook researches in the archives and made an analysis of the press in order to establish a reliable list of earthquakes. Several categories of sources were used: narrative and administrative sources, contemporaneous studies, letters sent to the scientific institutions and press. We could confirm that 84 earthquakes are real and determine a list of fake earthquakes that are unfortunately present in the traditional catalogs. In the list of fake earthquakes, we highlighted several events that we consider doubtful and that require additional researches, especially several earthquakes in mining zone. We compiled our results as a four-column table providing the date of the earthquake, the supposed epicenter, the number of founded sources and the number of macroseismic datapoints. Based on the macroseismic datapoints, we estimated the intensities for every great phenomenon according to EMS-98 scale. The map of the epicenters indicates that the most active zone in the area during the XIXth century is the Lower Rhine

  12. Urban Scaling of Cities in the Netherlands.

    PubMed

    van Raan, Anthony F J; van der Meulen, Gerwin; Goedhart, Willem

    2016-01-01

    We investigated the socioeconomic scaling behavior of all cities with more than 50,000 inhabitants in the Netherlands and found significant superlinear scaling of the gross urban product with population size. Of these cities, 22 major cities have urban agglomerations and urban areas defined by the Netherlands Central Bureau of Statistics. For these major cities we investigated the superlinear scaling for three separate modalities: the cities defined as municipalities, their urban agglomerations and their urban areas. We find superlinearity with power-law exponents of around 1.15. But remarkably, both types of agglomerations underperform if we compare for the same size of population an agglomeration with a city as a municipality. In other words, an urban system as one formal municipality performs better as compared to an urban agglomeration with the same population size. This effect is larger for the second type of agglomerations, the urban areas. We think this finding has important implications for urban policy, in particular municipal reorganizations. A residual analysis suggests that cities with a municipal reorganization recently and in the past decades have a higher probability to perform better than cities without municipal restructuring.

  13. [Aquaculture in the Netherlands: problems and perspectives].

    PubMed

    Hogendoorn, H

    1986-11-15

    New interest is being focussed on the more than 100-year-old field of fish culture in the Netherlands. The systems of production available show varying degrees of control of the fish and their environment, and they have a corresponding yield: 0.01-250 kg/m3/year. The recently developed recirculation systems (40-80 kg/m3) make possible the commercial production of luxury species of fish, independently of climatological conditions and having minimum effects on the environment. Some technical aspects of reproduction, housing, nutrition, growth, health control and marketing of the fish require further attention. But the absence of a solid tradition of fish culture is the main problem in the development of fish culture in the Netherlands today. Good fish stockmanship is required at farmers' level. And the organisation and governmental support, that turned agriculture into a highly successful industry, are also essential. For the moment, the most promising commercial prospects are provided by a number of luxury fish species: trout, salmon, eel, sole, turbot, tilapia, catfish, seabass and seabream. A joint effort may help to overcome the remaining technical and logistical uncertainties.

  14. Access to health care for undocumented migrants: a comparative policy analysis of England and the Netherlands.

    PubMed

    Grit, Kor; den Otter, Joost J; Spreij, Anneke

    2012-02-01

    The presence of undocumented migrants is increasing in many Western countries despite wide-ranging attempts by governments to increase border security. Measures taken to control the influx of immigrants include policies that restrict access to publicly funded health care for undocumented migrants. These restrictions to health care access are controversial, and evidence suggests they do not always have the intended effect. This study provides a comparative analysis of institutional, actor-related, and contextual factors that have influenced health care policy development on undocumented migrants in England and the Netherlands. For undocumented migrants, England restricts its access to care at the point of service, while the Netherlands restricts through the payment system for services. The study includes an analysis of policy papers and semistructured, in-depth interviews with various actors in both countries. Findings confirm the influence of such contextual factors as immigration considerations and cost concerns on health care policy making in this area. However, these factors cannot explain the differences between the two countries. Previously enacted policies, especially the organization of the health care system, affected the kind of restrictions for undocumented migrants. Concerns about the side effects of generous treatment of undocumented migrants on other groups played a substantial role in formulating restrictive policies in both countries. Evidently, policy development and implementation is critically affected by institutional rules, which govern the degree of influence that doctors and professional medical associations have on the policy process.

  15. Mercury toxicity in livers of northern pike (Esox lucius) from Isle Royale, USA.

    PubMed

    Drevnick, Paul E; Roberts, Aaron P; Otter, Ryan R; Hammerschmidt, Chad R; Klaper, Rebecca; Oris, James T

    2008-04-01

    Many laboratory studies have documented that mercury can be toxic to fish, but it is largely unknown if mercury is toxic to fish in their natural environments. The objective of our study was to investigate the toxic effects of mercury on northern pike (Esox lucius) at Isle Royale, Michigan. In 124 northern pike from eight inland lakes, concentrations of total mercury in skin-on fillets ranged from 0.069 to 0.622 microg/g wet mass (wet wt). Concentrations of total mercury in livers increased exponentially compared with concentrations in fillets, to a maximum of 3.1 microg/g wet wt. Methylmercury constituted a majority of the mercury in livers with total mercury concentrations <0.5 microg/g wet wt, but declined to 28-51% of the mercury in livers with total mercury concentrations >0.5 microg/g wet wt. Liver color (absorbance at 400 nm) varied among northern pike and was positively related to liver total mercury concentration. The pigment causing variation in liver color was identified as lipofuscin, which results from lipid peroxidation of membranous organelles. An analysis of covariance revealed lipofuscin accumulation was primarily associated with mercury exposure, and this association obscured any normal accumulation from aging. We also documented decreased lipid reserves in livers and poor condition factors of northern pike with high liver total mercury concentrations. Our results suggest (i) northern pike at Isle Royale are experiencing toxicity at concentrations of total mercury common for northern pike and other piscivorous fish elsewhere in North America and (ii) liver color may be useful for indicating mercury exposure and effects in northern pike at Isle Royale and possibly other aquatic ecosystems and other fish species.

  16. Nearshore habitat and fish community associations of coaster brook trout in Isle Royale, Lake Superior

    USGS Publications Warehouse

    Gorman, O.T.; Moore, S.A.; Carlson, A.J.; Quinlan, H.R.

    2008-01-01

    We characterized the nearshore habitat and fish community composition of approximately 300 km of shoreline within and adjacent to the major embayments of Isle Royale, Lake Superior. Sampling yielded 17 species, of which 12 were widespread and represented a common element of the Lake Superior fish community, including cisco Coregonus artedi, lake whitefish C. clupeaformis, round whitefish Prosopium cylindraceum, lake trout Salvelinus namaycush, rainbow smelt Osmerus mordax, lake chub Couesius plumbeus, longnose sucker Catostomus catostomus, white sucker C. commersonii, trout-perch Percopsis omiscomaycus, ninespine stickleback Pungitius pungitius, burbot Lota lota, and slimy sculpin Cottus cognatus. The presence of brook trout S. fontinalis in an embayment was associated with the common species of the Isle Royale nearshore fish community, particularly cisco, longnose sucker, and round whitefish. However, brook trout were present in only five embayments and were common only in Tobin Harbor. Most Isle Royale embayments had broadly overlapping ranges of nearshore habitats. Within embayments, fish were distributed along a habitat gradient from less-protected rocky habitat near the mouth to highly protected habitat with mixed and finer substrates at the head. Embayments with brook trout had greater mean protection from the open lake, greater variation in depth, greater mean cover, and higher mean frequencies of large substrates (cobble, boulder, and bedrock). Within those embayments, brook trout were associated with habitat patches with higher mean frequencies of small substrates (particularly sand and coarse gravel). Within Tobin Harbor, brook trout were associated with midembayment habitat and species assemblages, especially those locations with a mixture of sand, gravel, and cobble substrates, an absence of bedrock, and the presence of round whitefish, white sucker, and trout-perch. Comparison of embayments with the model, Tobin Harbor, showed that six embayments

  17. Intraocular lens confusions: a preventable "never event" - The Royal Victorian Eye and Ear Hospital protocol.

    PubMed

    Zamir, Ehud; Beresova-Creese, Katarina; Miln, Linda

    2012-09-01

    Intraocular lens (IOL) confusions and errors are among the most common postoperative adverse events. Errors may occur at any stage from the decision to operate to the insertion of the IOL. The most common errors occur during IOL selection pre-operative preparation (anaesthesia given before recognition that the intended IOL is not available), or intraoperatively (wrong IOL implanted because of confusion in the operating room). We review the mechanisms of errors reported in the literature and describe the experience at The Royal Victorian Eye and Ear Hospital. We also describe the implementation of an error-detection protocol and provide qualitative data on its performance.

  18. Royal Dutch to launch Russian activity; Moscow to open Sakhalin areas to bids

    SciTech Connect

    Not Available

    1992-10-05

    This paper reports that units of the Royal Dutch/Shell Group are poised to take a role in the Russian petroleum industry. Shell Development Sakhalin BV agreed to join the MMM group conducting a feasibility study for development of Piltun-Astokhskoye and Lunskoye oil and gas fields off Sakhalin Island. And Shell Rossiya AO was registered in Moscow to operate upstream and downstream. Meantime, Moscow's ITAR-TASS news agency last week reported Russia will take international bids for exploration and development onshore and off Sakhalin Island.

  19. Royal Society reports on Science Base,' suggests five-year fellowships

    SciTech Connect

    Sweet, W.

    1992-12-01

    In October, Britain's Royal Society released its long-awaited report, 'The Future of the Science Base,' the product of an 18 month review of how the nation's basic research is organized and the factors that might make it more successful. The science base report has been treated with considerable respect in the United Kingdom. Its conclusions, which are related in this article, may be of interest to Americans, as many of the trends and dilemmas identified in this report are also found in the U.S. This article review the specific recommendations of the report and also lists demographic and funding information.

  20. Fossilized nuclei and chromosomes reveal 180 million years of genomic stasis in royal ferns.

    PubMed

    Bomfleur, Benjamin; McLoughlin, Stephen; Vajda, Vivi

    2014-03-21

    Rapidly permineralized fossils can provide exceptional insights into the evolution of life over geological time. Here, we present an exquisitely preserved, calcified stem of a royal fern (Osmundaceae) from Early Jurassic lahar deposits of Sweden in which authigenic mineral precipitation from hydrothermal brines occurred so rapidly that it preserved cytoplasm, cytosol granules, nuclei, and even chromosomes in various stages of cell division. Morphometric parameters of interphase nuclei match those of extant Osmundaceae, indicating that the genome size of these reputed "living fossils" has remained unchanged over at least 180 million years-a paramount example of evolutionary stasis.

  1. The understanding of monsters at the Royal Society in the first half of the eighteenth century.

    PubMed

    da Costa, P F

    2000-01-01

    In tune with an Enlightenment sensibility that focused on the search for order and regularities, monsters were given a marginal position in eighteenth-century medical works. By contrast, they had an important place at the Royal Society during the second half of the century. This article first focuses on the general interest in monsters within the context of the natural historical agenda and corporate activity of the Society and then addresses the medical understanding of monsters by members of the Society. Finally, it discusses some of the moral and social implications of their medicalization in eighteenth century England.

  2. Effect of royal jelly ingestion for six months on healthy volunteers

    PubMed Central

    2012-01-01

    Background Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans. Methods We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention. Results Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276). Conclusions Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects. PMID:22995464

  3. The use of colours on the the seventeenth century royal warship Vasa.

    PubMed

    Tångeberg, P

    2000-01-01

    The seventeenth-century Swedish Royal warship Vasa was painted and decorated with almost 500 figure sculptures and many carved ornaments. It is probably the most extensive sculptural work in wood to have been preserved from this period in European history. The ship's decorations are of particular importance given the scarcity of knowledge of how sculptures in general, and large ships in particular, were painted in Northern Europe during this period. About 20 different pigments have been characterized and it has been possible to reconstruct the appearance of many of the sculptures and to extend this knowledge to the ship's original appearance.

  4. Experiences of foreign European nurses in The Netherlands.

    PubMed

    de Veer, Anke; den Ouden, Dirk-Jan; Francke, Anneke

    2004-04-01

    As a result of the shortage of nurses, Dutch health care organizations want to recruit nurses from outside Europe (e.g. Indonesia, South Africa). The Dutch government, however, is not encouraging this policy and prefers to recruit within the European Union. In order to better support such nurses, it is important to know the problems European nurses encounter in The Netherlands. This study is about the experience of nurses from other European countries in The Netherlands. This paper addresses itself to three principal questions. First, how many nurses qualified in other EU or EU candidate states are starting to work in The Netherlands. Second, why do they come to The Netherlands. And finally what problems do they encounter when working in The Netherlands. A questionnaire has been send to all registered nurses trained in another EU or EU candidate state. The response has been 987 or 67%. Thus, far approximately 1500 nurses from other EU/candidate states have come to The Netherlands. Personal reasons, including marriage, are the most important reasons for their coming here. Half of the nurses took one or more courses before starting work in nursing in The Netherlands. These were often Dutch language courses. The nurses had to make a number of adjustments. Major difficulties were unfamiliarity with Dutch laws and the fiscal and social security systems, recognition of their qualifications and application for permits. Some basic issues, such as how to write a letter of application, caused problems. The language and unfamiliarity with the Dutch health care system made it difficult to find a job. When they had gained employment in nursing these problems remained the most serious. The conclusion is that international employment mobility in nursing is rather low in the case of The Netherlands. If the Dutch government decides to encourage the employment of nurses from abroad, several measures can be taken to make working in The Netherlands more attractive.

  5. [Adaptation of Einthoven's string galvanometer for electrocardiography in the Netherlands].

    PubMed

    Wyers, P J

    2001-12-22

    After the Dutch physiologist Willem Einthoven (1860-1927) published the construction of his string galvanometer in 1901, the development of electrocardiography in the Netherlands was slow. During the next twenty years only a few string galvanometers were in use in the Netherlands, mostly in physiology laboratories. Publications concerning electrocardiographic tests on patients were scarce. In 1924, Einthoven was awarded the Nobel Prize for Physiology and Medicine for discovering the mechanism of the electrocardiogram. From that moment onwards, electrocardiography developed rapidly in the Netherlands and during the following 30 years particular use was made of the French string galvanometer designed by Boulitte.

  6. Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila.

    PubMed

    Xin, Xiao-Xuan; Chen, Yong; Chen, Di; Xiao, Fa; Parnell, Laurence D; Zhao, Jing; Liu, Liang; Ordovas, Jose M; Lai, Chao-Qiang; Shen, Li-Rong

    2016-07-27

    The major royal-jelly proteins (MRJPs) are the main constituents responsible for the specific physiological role of royal jelly (RJ) in honeybees. Male and female Drosophila flies were fed diets containing either no MRJPs (A) or casein (B) at 1.25% (w/w) of diet or MRJPs at 1.25% (C), 2.50% (D), or 5.00% (E). Diets B, C, D, and E increased mean lifespan by 4.3%, 9.0%, 12.4%, and 13.9% in males and by 5.8%, 9.7%, 20.0%, and 11.8% in females in comparison to results from diet A, respectively. The diet supplemented with 2.50% MRJPs seems to have the optimal dose to improve both physiological and biochemical measures related to aging in both sexes. Interestingly, lifespan extension by MRJPs in Drosophila was positively associated with feeding and fecundity and up-regulation of copper and zinc-superoxide dismutase (CuZn-SOD) and the Egfr-mediated signaling pathway. This study provides strong evidence that MRJPs are important components of RJ for prolonging lifespan in Drosophila.

  7. Novel royal jelly proteins identified by gel-based and gel-free proteomics.

    PubMed

    Han, Bin; Li, Chenxi; Zhang, Lan; Fang, Yu; Feng, Mao; Li, Jianke

    2011-09-28

    Royal jelly (RJ) plays an important role in caste determination of the honeybee; the genetically same female egg develops into either a queen or worker bee depending on the time and amount of RJ fed to the larvae. RJ also has numerous health-promoting properties for humans. Gel-based and gel-free proteomics approaches and high-performance liquid chromatography-chip quadruple time-of-flight tandem mass spectrometry were applied to comprehensively investigate the protein components of RJ. Overall, 37 and 22 nonredundant proteins were identified by one-dimensional gel electrophoresis and gel-free analysis, respectively, and 19 new proteins were found by these two proteomics approaches. Major royal jelly proteins (MRJPs) were identified as the principal protein components of RJ, and proteins related to carbohydrate metabolism such as glucose oxidase, α-glucosidase precursor, and glucose dehydrogenase were also successfully identified. Importantly, the 19 newly identified proteins were mainly classified into three functional categories: oxidation-reduction (ergic53 CG6822-PA isoform A isoform 1, Sec61 CG9539-PA, and ADP/ATP translocase), protein binding (regucalcin and translationally controlled tumor protein CG4800-PA isoform 1), and lipid transport (apolipophorin-III-like protein). These new findings not only significantly increase the RJ proteome coverage but also help to provide new knowledge of RJ for honeybee biology and potential use for human health promotion.

  8. Keynes, Newton and the Royal Society: the events of 1942 and 1943.

    PubMed

    Kuehn, Daniel

    2013-03-20

    Most discussions of John Maynard Keynes's activities in connection with Newton are restricted to the sale in 1936 at Sotheby's of Newton's Portsmouth Papers and to Keynes's 1946 essay 'Newton, the Man'. This paper provides a history of Keynes's Newton-related work in the interim, highlighting especially the events of 1942 and 1943, which were particularly relevant to the Royal Society's role in the domestic and international promotion of Newton's legacy. During this period, Keynes lectured twice on Newton, leaving notes that would later be read by his brother Geoffrey in the famous commemoration of the Newton tercentenary in 1946. In 1943 Keynes assisted the Royal Society in its recognition of the Soviet celebrations and in the acquisition and preservation of more of the Newton library. In each instance Keynes took the opportunity to promote his interpretation of Newton as 'the last of the magicians': a scientist who had one foot in the pre-modern world and whose approach to understanding the world was as much intuitive as it was methodical.

  9. Observing the skies of Lisbon. Isaac de Sequeira Samuda, an estrangeirado in the Royal Society

    PubMed Central

    Vieira, Carla Costa

    2014-01-01

    Elected in 1723, Isaac de Sequeira Samuda (1681–1729) was the first Jewish Fellow of the Royal Society. He had arrived in London just a few years earlier, escaping from the Portuguese Inquisition. Despite his past, he had no difficulty in establishing links with his country's diplomatic representatives in London. A physician and adviser on scientific subjects, he became a conduit between the emerging world of Portuguese astronomy and the British scientific community. He reported to the Royal Society on astronomical observations made in the new observatories in Lisbon and helped with the acquisition of scientific instruments and books destined for Portugal. These activities were facets of Samuda's unusual career and the diverse though often converging associations that he established until his death. As the member of a network active in the diffusion of new ideas and in the modernization of Portuguese science, Samuda can be regarded as an estrangeirado, as this term has come to be used in the modern literature. PMID:24921106

  10. The 'royal disease'--haemophilia A or B? A haematological mystery is finally solved.

    PubMed

    Lannoy, N; Hermans, C

    2010-11-01

      'History can change blood. And blood can change the course of history'. Haemophilia is an illustration of this, as this congenital hereditary coagulation disorder, passed through the majority of royal European families at the beginning of the 20th century by Queen Victoria of England and Empress of the Indies, had indisputable political consequences, which led to one of the most defining moments of contemporary history: the Bolshevik Revolution. Today, none of Queen Victoria's living descendents carry haemophilia. Because of this, the characterization of haemophilia (deficit of either factor VIII or XI) and the identification of the causal mutation are rendered impossible. In 1991, a tomb containing the remains of Czar Nicolas II's entire family was discovered. A second tomb was discovered in 2007, allowing Russian and American scientists to fill in this gap in medical history. Following a scientific approach combining current genetic experimentation tools and the development of biological information technology, researchers were able to identify each body, allowing them to obtain precious genetic material from the young Czar Alexis, who was stricken by the disease, which revealed a causal substitution in the splice acceptor site of exon 4 in the F9 gene. This mutation that is responsible for haemophilia B had traumatized European royal families throughout the 20th century!

  11. Effect of Major Royal Jelly Proteins on Spatial Memory in Aged Rats: Metabolomics Analysis in Urine.

    PubMed

    Chen, Di; Liu, Fang; Wan, Jian-Bo; Lai, Chao-Qiang; Shen, Li-Rong

    2017-04-10

    Royal jelly (RJ) produced by worker honeybees is the sole food for the queen bee throughout her life as well as the larvae of worker bees for the first 3 days after hatching. Supplementation of RJ in the diet has been shown to increase spatial memory in rodents. However, the key constituents in RJ responsible for improvement of cognitive function are unknown. Our objective was to determine if the major royal jelly proteins (MRJPs) extracted from RJ can improve the spatial memory of aged rats. The spatial memory assay using the Morris water maze test was administered once to rats after a 14-week feeding. Metabolomics analysis based on quadrupole time-of-flight mass spectrometry was conducted to examine the differences in compounds from urine. Aged male rats fed MRJPs showed improved spatial memory up to 48.5% when compared to the control male aged rats fed distilled water. The metabolite pattern of the MRJPs-fed aged rats was regressed to that of the young rats. Compounds altered by MRJPs were mapped to nicotinate and nicotinamide metabolism, cysteine taurine metabolism, and energy metabolism pathways. In summary, MRJPs may improve spatial memory and possess the potential for prevention of cognitive impairment via the cysteine and taurine metabolism and energy metabolism pathways in aged rats.

  12. Molecular genetic analysis on the remains of the Dark Countess: Revisiting the French Royal family.

    PubMed

    Parson, Walther; Berger, Cordula; Sänger, Timo; Lutz-Bonengel, Sabine

    2015-11-01

    The "Dark Counts" were a mysterious couple that appeared in the Thuringian village Eishausen in 1807. After living in self imposed solitude for 30 years the woman died and was buried under the name Sophia Botta. Her companion, who presented himself as Vavel de Versay, died in 1845 and was later identified as Leonardus Cornelius van der Valck, secretary of the Dutch embassy in Paris. Their lifestyle led to speculations that she was the true princess Marie Thérèse Charlotte of France, daughter of Louis XVI and Marie Antoinette. According to these speculations she was substituted by another young woman on a voyage from Paris to Vienna. Molecular genetic analyses were set out to test the remains attributed to the Dark Countess. Mitochondrial DNA testing brought concordant results determined in two forensic laboratories (Innsbruck, Austria and Freiburg, Germany) on parallel samples of the remains. The results were in exclusion to both, the mitochondrial lineage earlier reported for the French Royal family and the mitochondrial haplotype observed in a living descendant of the Royal family.

  13. Abnormal chemical element concentrations in lichens of Isle Royale National Park

    USGS Publications Warehouse

    Bennett, J.P.

    1995-01-01

    Lichens have been used for many years to monitor changes in deposited airborne chemical elements in many areas, but few studies have focused on areas suspected of experiencing slightly elevated pollution. Detection of subtle patterns of slightly elevated pollutants calls for developing several lines of evidence as opposed to single line studies used in heavily polluted areas. This study of two lichen species, Hypogymnia physodes and Evernia mesomorpha, in Isle Royale National Park, Michigan compares the concentrations and ranks of elements with the concentrations and ranks of the elements in the earth's crust, changes in element concentrations over a nine year period, and the geography of element concentrations in the park. S, Zn, Pb, Cd and Se were elevated in both species and higher in rank compared to the concentrations and ranks in the earth's crust. Toxic elements increased 123% in Hypogymnia and 62% in Evernia over 9 years, compared to increases of 45% and 59% for non-toxic elements in each species, respectively. Geographically, the lichens at certain localities with higher exposures experienced higher than average element concentrations. Finally, tissue concentrations of Mn, S and Se at some localities were above levels known to be either toxic or similar to those found in polluted areas. These four lines of evidence suggest that Isle Royale National Park is experiencing the onset of chronic air pollution stress from a number of sources.

  14. Fruit quality of Redhaven and Royal Glory peach cultivars on seven different rootstocks.

    PubMed

    Orazem, Primoz; Stampar, Franci; Hudina, Metka

    2011-09-14

    Two peach cultivars, Redhaven and Royal Glory, grafted on seven different rootstocks (Adesoto, Barrier 1, GF 677, Ishtara, Monegro, Penta, and peach seedling) were analyzed for tree vigor and yield. Fruit of similar ripeness (fruit firmness) was analyzed in terms of pomological (fruit weight, soluble solids content) and biochemical parameters (individual sugars, organic acids, phenolic acids in the flesh and peel, as well as flavonols and anthocyanins in the peel). A uniform effect of rootstock on tree size was evident in the cases of both cultivars. The Ishtara rootstock induced weak tree growth; Adesoto, Penta and peach seedling semivigorous growth; and Barrier 1, GF 677, and Monegro vigorous tree growth. We recorded higher yields in the Redhaven cultivar, while no significant differences in yield in the fourth growing season were found among the rootstocks for each cultivar. Rootstock had no effect on soluble solids in the Redhaven cultivar, while in the Royal Glory it did. Penta yielded the highest soluble solids content levels, while Adesoto and Monegro were associated with low levels. In the fruit from both cultivars, the rootstock had a significant influence on individual sugars, organic acids, and phenolic acids in the pulp. We also found that phenolic acids in the pulp and skin were more affected by the rootstock than other secondary metabolites analyzed, regardless of the cultivar.

  15. Keynes, Newton and the Royal Society: the events of 1942 and 1943

    PubMed Central

    Kuehn, Daniel

    2013-01-01

    Most discussions of John Maynard Keynes's activities in connection with Newton are restricted to the sale in 1936 at Sotheby's of Newton's Portsmouth Papers and to Keynes's 1946 essay ‘Newton, the Man’. This paper provides a history of Keynes's Newton-related work in the interim, highlighting especially the events of 1942 and 1943, which were particularly relevant to the Royal Society's role in the domestic and international promotion of Newton's legacy. During this period, Keynes lectured twice on Newton, leaving notes that would later be read by his brother Geoffrey in the famous commemoration of the Newton tercentenary in 1946. In 1943 Keynes assisted the Royal Society in its recognition of the Soviet celebrations and in the acquisition and preservation of more of the Newton library. In each instance Keynes took the opportunity to promote his interpretation of Newton as ‘the last of the magicians’: a scientist who had one foot in the pre-modern world and whose approach to understanding the world was as much intuitive as it was methodical. PMID:24686919

  16. Purification, crystallization and preliminary X-ray diffraction analysis of royal palm tree (Roystonea regia) peroxidase

    SciTech Connect

    Watanabe, Leandra; Nascimento, Alessandro S.; Zamorano, Laura S.; Shnyrov, Valery L.; Polikarpov, Igor

    2007-09-01

    The purification, crystallization, X-ray diffraction data acquisition and molecular-replacement results of royal palm tree (R. regia) peroxidase are described. Royal palm tree peroxidase (RPTP), which was isolated from Roystonea regia leaves, has an unusually high stability that makes it a promising candidate for diverse applications in industry and analytical chemistry [Caramyshev et al. (2005 ▶), Biomacromolecules, 6, 1360–1366]. Here, the purification and crystallization of this plant peroxidase and its X-ray diffraction data collection are described. RPTP crystals were obtained by the hanging-drop vapour-diffusion method and diffraction data were collected to a resolution of 2.8 Å. The crystals belong to the trigonal space group P3{sub 1}21, with unit-cell parameters a = b = 116.83, c = 92.24 Å, and contain one protein molecule per asymmetric unit. The V{sub M} value and solvent content are 4.07 Å{sup 3} Da{sup −1} and 69.8%, respectively.

  17. Quantitative Analysis of Apisin, a Major Protein Unique to Royal Jelly

    PubMed Central

    Arai, Yasuko; Kato, Kenji

    2016-01-01

    Apisin, a protein that is unique to royal jelly (RJ), is known to compose the greater part of the RJ proteins and to exist as a heterooligomer containing major royal jelly protein 1 and apisimin. However, few reports on the methods for quantifying apisin have been published. Thus, we attempted to quantify apisin using HPLC, a widely used analytical technique, as described below. Isoelectric precipitation and size-exclusion chromatography were used to obtain the purified protein, which was identified as apisin by SDS-PAGE and LC-MS analyses. The purified apisin was lyophilized and then used to generate a calibration curve to quantify apisin in RJ. The apisin content was fairly constant (i.e., 3.93 to 4.67 w/w%) in natural RJ. This study is the first to describe a simple, standardized method for quantifying apisin using HPLC and suggests that apisin can be used as a benchmark for future evaluations of RJ quality. PMID:27721892

  18. South[ern] Africa's "Dar ul-'Ulums": Institutions of Social Change for the Common Good?

    ERIC Educational Resources Information Center

    Haron, Muhammed

    2014-01-01

    Muslim communities in principally non-Muslim nation states (e.g. South Africa, United States of America, the United Kingdom and the Netherlands) established a plethora of Muslim theological institutions. They have done so with the purpose of educating and reinforcing their Muslim identity. These educational structures have given rise to numerous…

  19. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses.

    PubMed

    Sugiyama, Tsuyoshi; Takahashi, Keita; Mori, Hiroshi

    2012-12-01

    Royal jelly is a food for queen and larvae honeybees. 10-Hydroxy-trans-2-decenoic acid (10H2DA; "royal jelly acid") is the principal lipid component in royal jelly. Several pharmacological activities of 10H2DA have been reported: anti-tumor, anti-biotic, immunomodulatory, estrogenic and neurogenic. We recently revealed an inhibitory effect of 10H2DA in innate immune signals. Despite appreciable advances in studies on innate immune signals after the identification of Toll-like receptors as innate immune receptors, few studies have reported the effect of 10H2DA on innate immune signals. In this review, we focus on recent advances in the evaluation of the biological activities of 10H2DA (especially immunomodulatory activities). We also discuss the molecular mechanisms underpinning these biological activities, which could lead to new therapeutic targets for the treatment of immune disorders.

  20. The Royal Society, natural history and the peoples of the 'New World(s)', 1660-1800.

    PubMed

    Gascoigne, John

    2009-12-01

    This paper focuses on the response of the Royal Society to the increasing contact with parts of the globe beyond Europe. Such contact was in accord with the programme of Baconian natural history that the early Royal Society espoused, but it also raised basic questions about the extent and nature of the pursuit of natural history. In particular, the paper is concerned with the attention paid to one particular branch of natural history, the study of other peoples and their customs. Such scrutiny of other peoples in distant lands raised basic questions about what methods natural history should employ and the extent to which it could serve as a foundation for more general and theoretical claims. By taking a wide sweep from the beginnings of the Royal Society until the end of the eighteenth century it is hoped light will be shed on the changing understanding of natural history over this period.

  1. Food to some, poison to others - honeybee royal jelly and its growth inhibiting effect on European Foulbrood bacteria.

    PubMed

    Vezeteu, Thomas V; Bobiş, Otilia; Moritz, Robin F A; Buttstedt, Anja

    2017-02-01

    Honeybee colonies (Apis mellifera) serve as attractive hosts for a variety of pathogens providing optimal temperatures, humidity, and an abundance of food. Thus, honeybees have to deal with pathogens throughout their lives and, even as larvae they are affected by severe brood diseases like the European Foulbrood caused by Melissococcus plutonius. Accordingly, it is highly adaptive that larval food jelly contains antibiotic compounds. However, although food jelly is primarily consumed by bee larvae, studies investigating the antibiotic effects of this jelly have largely concentrated on bacterial human diseases. In this study, we show that royal jelly fed to queen larvae and added to the jelly of drone and worker larvae, inhibits not only the growth of European Foulbrood-associated bacteria but also its causative agent M. plutonius. This effect is shown to be caused by the main protein (major royal jelly protein 1) of royal jelly.

  2. [Influence of honey, royal jelly and propolis on accelerating acetate healing of experimental gastric ulcers in rats].

    PubMed

    Belostotskiĭ, N I; Kas'ianenko, V I; Dubtsova, E A; Lazebnik, L B

    2009-01-01

    This study examines gastric acetic ulcer healing in the rat after administration of honey, royal jelly and propolis into the stomach. Chronic gastric ulcers were induced in male Wistar rats by the application of 100% acetic acid to the serosal surface of the stomach on 60 sec. Bee-keeping products were administrated into the stomach from 2nd to 7th day after acetic ulcer induction. On 7th day animals were killed, and ulcer area was measured in mm2. In gastric juice pH and activity of pepsin were measured. The healing of acetic ulcers is accelerated with the administration of honey, royal jelly or propolis during six days. The largest healing effect was demonstrated with propolis and royal jelly, smaller one with the honey. It was revealed decrease of stomach acid secretion in the rats, which have received bee-keeping products versus the rats of control group.

  3. [Population forecasts for the Netherlands, 1986-2035].

    PubMed

    Cruijsen, H

    1987-02-01

    Results of the 1986 official population forecasts for the Netherlands are presented, and the assumptions made in their preparation are described. Comparisons are made with forecasts for 1985. Three alternative variations of the forecasts are included. (SUMMARY IN ENG)

  4. Netherlands to Aid Central, Eastern Europe in Halting Pollution Effects.

    ERIC Educational Resources Information Center

    O'Sullivan, Dermot A.

    1991-01-01

    Discussed are efforts originating in the Netherlands to assist the Soviet Union and Eastern European counties to form and carry out significant air and water pollution improvement policies. Examples of proposals and programs being formed are described. (CW)

  5. [Determination of four insecticide residues in honey and royal jelly by gas chromatography-negative chemical ionization mass spectrometry].

    PubMed

    Xia, Guanghui; Shen, Weijian; Yu, Keyao; Wu, Bin; Zhang, Rui; Shen, Chongyu; Zhao, Zengyun; Bian, Xiaohong; Xu, Jiyang

    2014-07-01

    A method was developed for the determination of four insecticide residues in honey and royal jelly by gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS). The honey and royal jelly samples were treated with different preparation methods as the result of the different components. The honey sample was extracted with ethyl acetate and cleaned up with primary second amine, and the royal jelly sample was extracted with acetonitrile-water (1:1, v/v), and cleaned up with a C18 solid-phase extraction column. Finally, the extracts of the honey and royal jelly were analyzed by GC-NCI/MS in selected ion monitoring (SIM) mode separately. External standard calibration method was used for quantification. The linearities of calibration curves of the four insecticides were good with the correlation coefficients greater than 0.99 in the range of 50-500 microg/L. The limits of the detection (LODs) of the four insecticides were in the range of 0.12- 5.0 microg/kg, and the limits of the quantification (LOQs) were in the range of 0.40-16.5 microg/kg. The recoveries of the four insecticides spiked in honey and royal jelly at three spiked levels (10, 15 and 20 microg/kg) were in the range of 78.2 -110.0%, and the relative standard deviations (RSDs) were all below 14%. The sensitivity and selectivity of this method were good with no interfering peaks. The proposed method is simple quick and effective to analyze the four insecticide residues in honey and royal jelly.

  6. Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats

    PubMed Central

    Amirshahi, Tayebeh; Najafi, Gholamreza; Nejati, Vahid

    2014-01-01

    Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. Objective: The aim of present study was to evaluate protective effect of royal jelly on sperm parameters and malondialdehyde (MDA) production in rat. Materials and Methods: Forty adult male wistar rats (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat(. Royal Jelly group (RJG) received jelly (100 mg/kg daily) for 48 days orally. Bleomycin group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. Royal Jelly+ Bleomycin group (RJ+BLG) received royal Jelly (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum testosterone and MDA concentrations were measured as well. Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as testosterone concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. Royal jelly improved Bleomycin-induced toxicity on sperm parameters and testosterone and MDA concentrations. Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters. This article extracted from M.Sc. thesis. (Tayebeh amirshahi) PMID:24799882

  7. Widespread Usutu virus outbreak in birds in the Netherlands, 2016.

    PubMed

    Rijks, J M; Kik, M L; Slaterus, R; Foppen, Rpb; Stroo, A; IJzer, J; Stahl, J; Gröne, A; Koopmans, Mgp; van der Jeugd, H P; Reusken, Cbem

    2016-11-10

    We report a widespread Usutu virus outbreak in birds in the Netherlands. Viral presence had been detected through targeted surveillance as early as April 2016 and increased mortality in common blackbirds and captive great grey owls was noticed from August 2016 onwards. Usutu virus infection was confirmed by post-mortem examination and RT-PCR. Extensive Usutu virus activity in the Netherlands in 2016 underlines the need to monitor mosquito activity and mosquito-borne infections in 2017 and beyond.

  8. Evaluation of the Netherlands' International Test Facility for Smart Grids

    SciTech Connect

    Palmintier, Bryan; Pratt, Annabelle

    2015-06-01

    The Netherlands Enterprise Agency (Rijksdienst voor Ondernemend Nederland, or RVO) engaged the U.S. National Renewable Energy Laboratory (NREL) for two primary purposes: to evaluate the International Test Facility for Smart Grids (ITF) sponsored by RVO and to learn best practices for integrated test facilities from NREL's Energy Systems Integration Facility (ESIF). This report covers the ITF evaluation and is largely based on a one-week visit to the Netherlands in November 2014.

  9. Widespread Usutu virus outbreak in birds in the Netherlands, 2016

    PubMed Central

    Rijks, JM; Kik, ML; Slaterus, R; Foppen, RPB; Stroo, A; IJzer, J; Stahl, J; Gröne, A; Koopmans, MGP; van der Jeugd, HP; Reusken, CBEM

    2016-01-01

    We report a widespread Usutu virus outbreak in birds in the Netherlands. Viral presence had been detected through targeted surveillance as early as April 2016 and increased mortality in common blackbirds and captive great grey owls was noticed from August 2016 onwards. Usutu virus infection was confirmed by post-mortem examination and RT-PCR. Extensive Usutu virus activity in the Netherlands in 2016 underlines the need to monitor mosquito activity and mosquito-borne infections in 2017 and beyond. PMID:27918257

  10. NEWS: Institute news

    NASA Astrophysics Data System (ADS)

    2000-07-01

    When Mary took up her appointment in the Institute's Education Department in June 1997, she indicated that she wished to return to teaching in two or three years. We have just heard that in September she will be joining the staff of the Science Department at Camden Girls' School, London. Mary's departure from the Institute is a great loss to the Department, where she has worked tirelessly, and with great imagination, to support those who teach physics at all secondary levels - and at primary level too when the opportunity presented itself. She has made tremendous contributions to the careers side of the Department's work, supporting careers events, providing informal training for others willing to do the same, helping to develop new careers materials and identifying people whom the Institute could use as role models or as the subject of case studies in print or electronic publications. Mary has been equally happy and willing to support pupils, students and teachers, and has been a wonderful role model herself, coming from an industrial research background, training for teaching after a career break and willing and able to teach biology, chemistry and design technology as well as physics. Mary has also written and edited Phases virtually single-handed. We are delighted to hear that Mary will continue to support the department's work as one of its teacher `volunteers'. Ilya Eigenbrot We are pleased to report that Ilya Eigenbrot, who will be known to some through his work at the Royal Institution and his appearances at the Christmas Lectures in a technical support role, has agreed to give the IOP Schools (touring) Lecture next year. The subject will be Lasers and this will follow nicely on to Zbig's lecture this year. Resources (print) Physics on Course The tenth issue of the Institute's popular guide to higher education, Physics on Course 2001, will be published early in July and distributed to all schools and colleges in the United Kingdom and the Republic of

  11. Hydrocarbon Induced Seismicity in Northern Netherlands

    NASA Astrophysics Data System (ADS)

    Dost, B.; Spetzler, J.; Kraaijpoel, D.; Caccavale, M.

    2015-12-01

    The northern Netherlands has been regarded aseismic until the first earthquakes started in 1986, after more than 25 years of gas production from the one of the largest on-shore gas-fields in the World, the Groningen field, and accompanying smaller gas fields. Due to the shallow sources, at approximately 3 km depth, even small magnitude events cause considerable damage to buildings in the region. Since the largest recorded event in the Groningen field in 2012 with ML= 3,6, more than 30.000 damage claims were received by the mining company. Since 1995 a seismic monitoring network is operational in the region, consisting of 8 200m deep boreholes with 4 levels of 3C 4,5 Hz geophones. The network was designed for a location threshold of ML=1,5 over a 40x 80 km region. Average station separation was 20 km. At the end of 2014, 245 events have been recorded with ML ≥ 1,5, out of a total of 1100. Since 2003 a new mining law is in place in the Netherlands, which requires for each gas field in production a seismic risk analysis. Initially, due to the small number of events for specific fields, a general hazard (PSHA) was calculated for all gas-fields and a maximum magnitude was estimated at ML = 3,9. Since 2003 an increase in the activity rate is observed for the Groningen field, leading to the development of new models and a re-assessment of parameters like the maximum magnitude. More recently these models are extended to seismic risk, where also the fragility of the regional buildings is taken into account. Understanding the earthquake process is essential in taking mitigation measures. Continued research is focused on reducing the uncertainties in the hazard and risk models and is accompanied by an upgrade of the monitoring network. In 2014 a new dense network was designed to monitor the Groningen gas field in this region (30*40 km) with an average separation of 4 km. This allows an improved location threshold (M>0,5) and location accuracy (50-100m). A detailed P- and S

  12. Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Main royal jelly protein 1 (MRJP1) is the most abundant member of the main royal jelly protein (MRJP) family among honeybees. Mature MRJP1 cDNA of the Chinese honeybee (Apis cerana cerana MRJP1, or AccMRJP1) was expressed in Pichia pastoris. SDS-PAGE showed that recombinant AccMRJP1 was identical in...

  13. From RAF to RN--the transition from Princess Mary's RAF Nursing Service (PMRAFNS) to Queen Alexandra's Royal Naval Nursing Service (QARNNS).

    PubMed

    Masawi, S K

    2015-01-01

    I transferred from the Royal Air Force to the Royal Navy (RN) on 10 July 2014. I would like to share my experiences as a junior RN Officer during Op GRITROCK, looking at some of the similarities and differences between the two Services and their deployed environments: maritime and air.

  14. [Psychiatric institutions in the regno delle due Sicilie].

    PubMed

    Leoni, F

    1993-01-01

    Before 1510 there wasn't a single hospital in Southern Italy which took in mental patients, with the possible exception of L'ospedale degli Incurabili, which in any case dealt with other kinds of illnesses as well. Finally, in 1813 the decision was taken to found an institution in the city of Aversa which would deal exclusively with mental patients. This institution was put under the control of Giovanni Maria Linguiti. He took care of all patients using his therapeutic methods, with such excellent results that his reputation spread outside the kingdom. In 1816 in Sicily, an attempt was made to repeat the success of Aversa, but not until 1824 was it decided that L'ospizio di Santa Teresa should care for mental patients. Don Pietro Pisani was delegated to coordinate that hospital and, in 1827, he published a number of theories and guidelines concerning mental healthcare similar to those of Linguiti. In December 1864 a Royal Decree forced through parliament a statute which laid down the rules for the reorganization of these hospitals. Finally in August 1874, after numerous financial difficulties and struggles between political bodies and health service management, a Royal Decree was established and a new guiding statute was passed.

  15. Large outbreak of Salmonella Thompson related to smoked salmon in the Netherlands, August to December 2012.

    PubMed

    Friesema, I; de Jong, A; Hofhuis, A; Heck, M; van den Kerkhof, H; de Jonge, R; Hameryck, D; Nagel, K; van Vilsteren, G; van Beek, P; Notermans, D; van Pelt, W

    2014-10-02

    On 15 August 2012, an increase in the number of Salmonella Thompson cases was noticed by the Salmonella surveillance in the Netherlands. A case–control study was performed, followed by a food investigation. In total 1,149 cases were laboratory-confirmed between August and December 2012 of which four elderly (76–91 years) were reported to have died due to the infection. The cause of the outbreak was smoked salmon processed at a single site. The smoked salmon had been continuously contaminated in the processing lines through reusable dishes, which turned out to be porous and had become loaded with bacteria. This is the largest outbreak of salmonellosis ever recorded in the Netherlands. The temporary closure of the processing site and recall of the smoked salmon stopped the outbreak. An estimated four to six million Dutch residents were possibly exposed to the contaminated smoked salmon and an estimated 23,000 persons would have had acute gastroenteritis with S. Thompson during this outbreak. This outbreak showed that close collaboration between diagnostic laboratories, regional public health services, the national institute for public health and the food safety authorities is essential in outbreak investigations.

  16. Two major mumps genotype G variants dominated recent mumps outbreaks in the Netherlands (2009-2012).

    PubMed

    Gouma, Sigrid; Sane, Jussi; Gijselaar, Daphne; Cremer, Jeroen; Hahné, Susan; Koopmans, Marion; van Binnendijk, Rob

    2014-05-01

    During three seasons of mumps outbreaks in the Netherlands (September 2009-August 2012), 822 mumps cases were laboratory-confirmed at the National Institute for Public Health and the Environment (RIVM). Most patients were vaccinated young adults. Given the protracted endemic circulation, we studied the genetic diversity and changes of mumps virus over a period of 3 years. Phylogenetic analysis of the small hydrophobic (SH) gene (316 bp) was performed on a representative set of 808 specimens that tested positive for mumps via PCR. Additionally, the haemagglutinin/neuraminidase (HN) gene (1749 bp) and fusion (F) gene (1617 bp) were sequenced for a subset of samples (n = 17). Correlations between different sequence types and epidemiological and clinical data were investigated. The outbreaks in the Netherlands were dominated by two SH gene sequence types within genotype G, termed MuVs/Delft.NLD/03.10 (variant 1) and MuVs/Scheemda.NLD/12.10 (variant 2). Sequence analysis of the HN and F genes indicated that the outbreaks were initiated by separately introduced genetic lineages. The predominance of variant 2 by the end of the first outbreak season could not be explained by any of the epidemiological factors investigated. Orchitis was more frequently reported in males infected with variant 2, irrespective of age and vaccination status. These findings illustrate genetic heterogeneity of an emerging mumps genotype, and raise questions about the mechanisms driving mumps epidemiology and immunity in relation to vaccination.

  17. Overcoming fragmentation in health care: chronic care in Austria, Germany and The Netherlands.

    PubMed

    Nolte, Ellen; Knai, Cécile; Hofmarcher, Maria; Conklin, Annalijn; Erler, Antje; Elissen, Arianne; Flamm, Maria; Fullerton, Brigit; Sönnichsen, Andreas; Vrijhoef, Hubertus J M

    2012-01-01

    The growing recognition of care fragmentation is causing many countries to explore new approaches to healthcare delivery that can bridge the boundaries between professions, providers and institutions and so better support the rising number of people with chronic health problems. This paper examines the role of the regulatory, funding and organisational context for the development and implementation of approaches to chronic care, using examples from Austria, Germany and the Netherlands. We find that the three countries have implemented a range of policies and approaches to achieve better coordination within and across the primary and secondary care interface and so better meet the needs of patients with chronic conditions. This has involved changes to the regulatory framework to support more coordinated approaches to care (Austria, Germany), coupled with financial incentives (Austria, Germany) or changes in payment systems (the Netherlands). What is common to the three countries is the comparative 'novelty' of policies and approaches aimed at fostering coordinated care; however, the evidence of their impact remains unclear.

  18. ['Advanced trauma life support' in Netherlands].

    PubMed

    van Vugt, A B

    2000-10-28

    Introduction of the principles of advanced trauma life support (ATLS) in the management of accident victims has been in progress in the Netherlands since 1995. The main ATLS principles are that the aid giver treats the most dangerous disorder first and does no further damage. After assessment and, if necessary, treatment of the airways, the respiration, the circulation and any craniocerebral injury, an exploratory examination is carried out. Physicians receive theoretical and practical instructions in this form of management during an intensive two-day course, counselled by a coordinating organization in the USA. Most of those attending are interns in general surgery, traumatology and orthopaedics, gatekeeper doctors of emergency rooms and army medical officers. The standardized way of thinking improves the communication and understanding between the various disciplines involved in trauma care, in part because there exist comparable programmes for ambulance care and emergency care. Other measures improving the quality of trauma care are regionalization of the trauma care, medical helicopter teams and evaluation of the effects of ATLS as an operating procedure.

  19. [The first woman surgeons in the Netherlands].

    PubMed

    Mulder, M; De Jong, E

    1997-01-01

    This article describes the position of woman surgeons in the Netherlands. In 1913 the first woman, Heleen Robert, was accepted as member of the Dutch Society of Surgery. Three others, Jeanne Knoop, Frieda van Hasselt and Rosalie Wijnberg, followed during the next ten years. The nomination of Rosalie Wijnberg caused a turbulent discussion as she was working as a gynaecologist and not as a surgeon. One can wonder about this argument as other members were gynaecologists too. It seems that the male attitudes towards women were changing as more women entered the male dominated field. Nevertheless, from 1931 on, the year in which the registration of specialists was created, a number of women succeeded in obtaining a registration in surgery. Four of them were interviewed: dr. D.A.E. Norel, A.G. Wiersum-de Kwaadsteniet, J. Leeksma-Lievense and A.A. Fierstra. The general opinion still is that surgery is not a female profession. At the moment there are some twenty women working as general surgeon compared to a seven hundred men.

  20. AN AUTOPSIC ART: DRAWINGS OF 'DR GRANVILLE'S MUMMY' IN THE ROYAL SOCIETY ARCHIVES.

    PubMed

    Riggs, Christina

    2016-06-20

    In 1821 Augustus Bozzi Granville FRS unwrapped and dissected an ancient Egyptian mummy, presenting the results of his examination to the Royal Society in 1825. He commissioned artist Henry Perry to draw the process in stages; these drawings were subsequently engraved by James Basire for publication in Philosophical Transactions. This article presents the original drawings for the first time, allowing comparison with their engravings. Taken together with Granville's accounts of the unwrapping of the mummy, the drawings demonstrate the significant role of illustration and other visual practices in anatomical argumentation in the early nineteenth century, as well as the prestige that commissioned illustrations lent to the performance and dissemination of scientific expertise. Moreover, the drawings include one of the key visual tropes of race science--a skull in left-facing profile, mapped with a facial angle--and thus indicate the early incorporation of Egyptian mummies into typologies of race.

  1. Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat.

    PubMed

    Terayama, Yui; Matsuura, Tetsuro; Ozaki, Kiyokazu

    2017-01-01

    A 152-week-old male Royal College of Surgeons (RCS) rat kept as a non-treated animal in a long-term animal study presented with a soft mass in the anterior mediastinum, which adhered to the pleura of the lung. Histopathologically, the mass mainly consisted of round to short spindle-shaped tumor cells that had infiltrated through the hyperplastic thymic tissue. The tumor cells were arranged in loose to dense sheets. Nuclei were moderate in size and round to spindle-shaped, with small nucleoli. Almost all tumor cells exhibited abundant eosinophilic cytoplasm, including eosinophilic granules of a range of sizes. The granules of tumor cells exhibited metachromasia with toluidine blue stain and were positive for c-kit and mast cell protease II. These findings indicate that the tumor described here represents a rare case of spontaneous malignant mast cell tumor with thymic epithelial hyperplasia.

  2. Seventeenth-century 'treasure' found in Royal Society archives: the Ludus helmontii and the stone disease.

    PubMed

    Alfonso-Goldfarb, Ana Maria; Ferraz, Márcia Helena Mendes; Rattansi, Piyo M

    2014-09-20

    Our archival researches at the Royal Society reveal that a small envelope attached to a 1675 letter from an Antwerp apothecary, A. Boutens, contained a sample of the 'Ludus' prepared as a remedy for the 'stone disease' then sweeping through Europe, which was first announced in J. B. van Helmont's De lithiasi (1644). After examining the fascination with the medical use of the Ludus (which required the 'alkahest' for its preparation) and the tenacious efforts to procure it, we trace the fortunae of two other ludi in England, brought to and offered by Francis Mercurius van Helmont during his English sojourn. Both eventually found their way to the geologist John Woodward, one of them through Sir Isaac Newton. Finally we show how the allure of the Ludus helmontii vanished, with transformations in mineral analysis and reclassifications from Woodward to John Hill.

  3. Lessons From a 17-Year Radiosurgery Experience at the Royal Adelaide Hospital

    SciTech Connect

    Roos, Daniel E.; Brophy, Brian P.; Taylor, James

    2012-01-01

    Purpose: To illustrate some of the potential pitfalls of cranial stereotactic radiosurgery (SRS) and its planning based on prospectively gathered data from a 17-year experience at the Royal Adelaide Hospital. Methods and Materials: More than 250 treatments have been planned since 1993 using previously described standard SRS techniques for intracranial benign and malignant lesions. Results: Five case studies are presented (1 meningioma, 1 acoustic neuroma, 2 solitary brain metastasis, 1 arteriovenous malformation), each of which demonstrates at least one salutary lesson. Conclusions: Because SRS delivers a highly conformal dose distribution, it is unforgiving of any geographic miss due to inaccurate outlining and thus dependent on neuroradiological expertise and collaboration. There are also potentially significant implications of misdiagnosis in SRS cases without histological proof-in particular, presumed brain metastases.

  4. Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish

    SciTech Connect

    Paul E. Drevnick; Donald E. Canfield; Patrick R. Gorski

    2007-11-01

    Mercury contamination of fish is a global problem. Consumption of contaminated fish is the primary route of methylmercury exposure in humans and is detrimental to health. Newly mandated reductions in anthropogenic mercury emissions aim to reduce atmospheric mercury deposition and thus mercury concentrations in fish. However, factors other than mercury deposition are important for mercury bioaccumulation in fish. In the lakes of Isle Royale, U.S.A., reduced rates of sulfate deposition since the Clean Air Act of 1970 have caused mercury concentrations in fish to decline to levels that are safe for human consumption, even without a discernible decrease in mercury deposition. Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters. 71 refs., 3 figs., 1 tab.

  5. THE LOGIC OF SCIENTIFIC UNITY? MEDAWAR, THE ROYAL SOCIETY AND THE ROTHSCHILD CONTROVERSY 1971-72.

    PubMed

    Calver, Neil; Parker, Miles

    2016-03-20

    In 1971 Lord (Victor) Rothschild published his report for the government, The organisation and management of government R&D, and Sir Peter Medawar launched a campaign for the election of Sir Karl Popper to Fellowship of the Royal Society. We explore these two developments in the contexts of the then current views of the role and purpose of science, and their underpinning philosophy. Although the political battle was won by Rothschild, resulting in major changes to the funding and management of applied R&D, we argue that, despite this, Medawar's campaign for Popper provided an embattled science community with a philosophical basis for defending pure research and the unity of basic and applied science.

  6. Exploring and communicating knowledge of trees in the early royal society.

    PubMed

    Hartley, Beryl

    2010-09-20

    For nearly 150 years after its foundation, Fellows of the Royal Society collected information on trees, investigated their anatomy and physiology, promoted planting and improved planting practices, and introduced, naturalized and classified foreign species. Their discoveries and advice were widely disseminated and used. Historians have generally neglected this interest, although the Society's first publication was an influential work on trees. They have also overlooked the significance of Stephen Hales's remark in Vegetable Staticks--that he hoped his enquiries into the nature of plants would improve skills in agriculture and gardening-and his linking of sap movement to tree pruning. Fellows' experiments and field trials not only advanced knowledge of the structure, nutrition and growth of trees but also provided empirical evidence supporting instructions for cultivating them.

  7. Characterisation of particulate matter in the Royal Museum of Fine Arts, Antwerp, Belgium

    NASA Astrophysics Data System (ADS)

    Gysels, Kristin; Deutsch, Felix; Grieken, René Van

    Aerosol samples were collected during two campaigns in February and July 1999 both inside and outside the Koninklijk Museum voor Schone Kunsten (KMSK, Royal Museum of Fine Arts) in Antwerp. Bulk aerosol concentrations, as well as the composition of the individual particles, were determined. The influence of the outdoor aerosol was clearly visible. In winter, restoration and construction works constituted an additional indoor source of Ca-rich and Ca-Si particles. Along with sea salt, these were the main particle types identified in this season. In summer, S-rich particles were most frequent. The summer abundances of Ca-rich particles remained low, even though the museum is situated in a limestone building. Moreover, dry deposition samples were collected in order to determine what amount of particles could actually be deposited onto the works of art.

  8. The Phenotypic Effects of Royal Jelly on Wild-Type D. melanogaster Are Strain-Specific

    PubMed Central

    Morgan, Stefanie L.; Seggio, Joseph A.; Hicks, Jasmin A.; Sharp, Katherine A.; Axelrod, Jeffrey D.; Wang, Kevin C.

    2016-01-01

    The role for royal jelly (RJ) in promoting caste differentiation of honeybee larvae into queens rather than workers is well characterized. A recent study demonstrated that this poorly understood complex nutrition drives strikingly similar phenotypic effects in Drosophila melanogaster, such as increased body size and reduced developmental time, making possible the use of D. melanogaster as a model system for the genetic analysis of the cellular mechanisms underlying RJ and caste differentiation. We demonstrate here that RJ increases the body size of some wild-type strains of D. melanogaster but not others, and report significant delays in developmental time in all flies reared on RJ. These findings suggest that cryptic genetic variation may be a factor in the D. melanogaster response to RJ, and should be considered when attempting to elucidate response mechanisms to environmental changes in non-honeybee species. PMID:27486863

  9. Retrospective Analysis of Patient Presentations at the Sydney (Australia) Royal Easter Show from 2012 to 2014.

    PubMed

    Crabtree, Nathan; Mo, Shirley; Ong, Leon; Jegathees, Thuvarahan; Wei, Daniel; Fahey, David; Liu, Jia Jenny

    2017-04-01

    Introduction Comprehensive studies on the relationship between patient demographics and subsequent treatment and disposition at a single mass-gathering event are lacking. The Sydney Royal Easter Show (SRES; Sydney Olympic Park, New South Wales, Australia) is an annual, 14-day, agricultural mass-gathering event occurring around the Easter weekend, attracting more than 800,000 patrons per year. In this study, patient records from the SRES were analyzed to examine relationships between weather, crowd size, day of week, and demographics on treatment and disposition. This information would help to predict factors affecting patient treatment and disposition to guide ongoing training of first responders and to evaluate the appropriateness of staffing skills mix at future events. Hypothesis Patient demographics, environmental factors, and attendance would influence the nature and severity of presentations at the SRES, which would influence staffing requirements.

  10. Telecommunications model for continuing education of health professionals: the Royal Brompton case.

    PubMed

    Kotis, Takis

    2003-01-01

    Telemedicine is said to be helpful to both patients and providers, but we need real-world examples to demonstrate its effectiveness. This paper presents such an example. Royal Brompton, under the Tele-remedy Program of EC Telecom, conducted a project with the Children's Hospital of Athens, Greece, to provide remote diagnosis management and continuing education for heart disease, using European ISDN technology. Preliminary results showed that, when carried out in a large scale multi-site environment, Teleremedy program significantly reduced geographic and socio-economic isolation for the patient and the professional isolation for the physician. Comparison of original vs. transmitted data revealed no significant differences, with diagnosis accuracy of 100%.

  11. The discovery of microorganisms by Robert Hooke and Antoni Van Leeuwenhoek, fellows of the Royal Society.

    PubMed

    Gest, Howard

    2004-05-01

    The existence of microscopic organisms was discovered during the period 1665-83 by two Fellows of The Royal Society, Robert Hooke and Antoni van Leeuwenhoek. In Micrographia (1665), Hooke presented the first published depiction of a microganism, the microfungus Mucor. Later, Leeuwenhoek observed and described microscopic protozoa and bacteria. These important revelations were made possible by the ingenuity of Hooke and Leeuwenhoek in fabricating and using simple microscopes that magnified objects from about 25-fold to 250-fold. After a lapse of more than 150 years, microscopy became the backbone of our understanding of the roles of microbes in the causation of infectious diseases and the recycling of chemical elements in the biosphere.

  12. Molecular characterization of MRJP3, highly polymorphic protein of honeybee (Apis mellifera) royal jelly.

    PubMed

    Albert, S; Klaudiny, J; Simúth, J

    1999-05-01

    Major proteins of honey bee (Apis mellifera) royal jelly are members of the MRJP protein family. One MRJP protein termed MRJP3 exhibits a size polymorphism as detected by SDS-PAGE. In this report we show that polymorphism of the MRJP3 protein is a consequence of the polymorphism of a region with a variable number of tandem repeats (VNTR) located at the C-terminal part of the MRJP3 coding region. We present the characterization of five polymorphic alleles of MRJP3 by DNA sequencing. By PCR analyses, at least 10 alleles of distinct sizes were found in randomly sampled bees. Studies with nurse bees from a single honeybee colony revealed both Mendelian inheritance and very high variability of the MRJP3 genomic locus. The high variability and simple detection of the MRJP3 polymorphism may be useful for genotyping of individuals in studies of the honeybee.

  13. Sir Robert Stawell Ball (1840-1913): Royal Astronomer in Ireland and astronomy's public voice

    NASA Astrophysics Data System (ADS)

    Chapman, Allan

    2007-11-01

    Nineteenth-century Ireland, and especially Dublin, had a vibrant scientific tradition. And astronomy in particular was seriously cultivated, being part of an Irish tradition extending back to early medieval times. This paper examines principally the career of Sir Robert Stawell Ball, who, while holding three prestigious posts in Ireland, namely those of Andrews Professor at Trinity College, Dublin, Royal Astronomer of Ireland, and Director of the Dunsink Observatory, became famous for his genius as a popular astronomical interpreter, lecturer, and writer. The paper looks at Ball's wider career, the circumstances that provided a receptive market for astronomical information across the English-speaking world, and his massive outreach as both a lecturer and a writer.

  14. Management practices that concentrate visitor activities: Camping impact management at Isle Royale National Park, USA

    USGS Publications Warehouse

    Marion, J.L.; Farrell, T.A.

    2002-01-01

    This study assessed campsite conditions and the effectiveness of campsite impact management strategies at Isle Royale National Park, USA. Protocols for assessing indicators of vegetation and soil conditions were developed and applied to 156 campsites and 88 shelters within 36 backcountry campgrounds. The average site was 68 m2 and 83% of sites lost vegetation over areas less than 47 m2. Results reveal that management actions to spatially concentrate camping activities and reduce camping disturbance have been highly successful. Comparisons of disturbed area/overnight stay among other protected areas reinforces this assertion. These reductions in area of camping disturbance are attributed to a designated site camping policy, limitation on site numbers, construction of sites in sloping terrain, use of facilities, and an ongoing program of campsite maintenance. Such actions are most appropriate in higher use backcountry and wilderness settings.

  15. The letter from Dublin: climate change, colonialism, and the Royal Society in the seventeenth century.

    PubMed

    Vogel, Brant

    2011-01-01

    This article discusses an anonymous letter published in the Philosophical Transactions in 1676 that reports the theories of American colonists about the cause of their warming climate (cultivation and deforestation), and offers Ireland's colonial experience as a counterexample: Ireland was a colony with decreased cultivation, but the same perceived warming. That such an objection seemed necessary to the author shows that anthropogenic climate change could be a subject of debate and that the concept of climate was tied into theories of land use and to the colonial enterprise. Since he was liminal to both the Royal Society of London and the intellectual circles of Dublin, his skepticism, contextualized here, questions both the elite discourse and the discourse at the colonial periphery.

  16. History of the Royal College of Chiropractic Sports Sciences (Canada): the early years

    PubMed Central

    De Finney, John; Lawson, Gordon; Gryfe, David; Gillis-Lawson, Susan; Crawford, John P.

    2016-01-01

    In 1978 the Canadian Chiropractic Association recognized the need to establish an organization that would prepare chiropractors to treat athletic injuries and promote these services to sports organizations. Dr. Adrian Grice approached three chiropractors to establish such an organization. The Canadian Chiropractic Sports Academy (CCSA) was established in 1978. This was the start of the chiropractic sports movement which has seen chiropractors playing prominent roles as team doctors to professional and amateur teams and athletes and in the delivery of care at major national and international competitions. This paper will show the work done by the original founders of the CCSA which has helped to pave the way to the present level of acceptance of chiropractic sports injury management and performance enhancement and as the progenitor of the Royal College of Chiropractic Sports Sciences Canada. PMID:28065996

  17. Profile: Vanessa Cameron – 36 years at the Royal College of Psychiatrists

    PubMed Central

    Poole, Rob; Robinson, Catherine A.

    2016-01-01

    On 16 December 2016, Vanessa Cameron retires as Chief Executive of the Royal College of Psychiatrists. She started working there in September 1980 and in 1984 she became Secretary of the College, the role that preceded chief executive. The College was formed in 1971, so Vanessa has been present for most of its lifetime. It has been a period of continuous change that has seen psychiatry leave the old mental hospitals, expand considerably in the late 1990s and early part of the 21st century, and come under huge pressure more recently. Although she has never worked within mental health services, Vanessa has been at the heart of British psychiatry for 36 years. She was awarded an MBE in the 2013 New Year's Honours list for services to psychiatry. We interviewed Vanessa at 21 Prescot Street on 3 August 2016. PMID:28377815

  18. The royal road for genetic algorithms: Fitness landscapes and GA performance

    SciTech Connect

    Mitchell, M.; Holland, J.H. ); Forrest, S. . Dept. of Computer Science)

    1991-01-01

    Genetic algorithms (GAs) play a major role in many artificial-life systems, but there is often little detailed understanding of why the GA performs as it does, and little theoretical basis on which to characterize the types of fitness landscapes that lead to successful GA performance. In this paper we propose a strategy for addressing these issues. Our strategy consists of defining a set of features of fitness landscapes that are particularly relevant to the GA, and experimentally studying how various configurations of these features affect the GA's performance along a number of dimensions. In this paper we informally describe an initial set of proposed feature classes, describe in detail one such class ( Royal Road'' functions), and present some initial experimental results concerning the role of crossover and building blocks'' on landscapes constructed from features of this class. 27 refs., 1 fig., 5 tabs.

  19. The logic of scientific unity? Medawar, the Royal Society and the Rothschild controversy 1971–72

    PubMed Central

    Calver, Neil; Parker, Miles

    2016-01-01

    In 1971 Lord (Victor) Rothschild published his report for the government, The organisation and management of government R&D, and Sir Peter Medawar launched a campaign for the election of Sir Karl Popper to Fellowship of the Royal Society. We explore these two developments in the contexts of the then current views of the role and purpose of science, and their underpinning philosophy. Although the political battle was won by Rothschild, resulting in major changes to the funding and management of applied R&D, we argue that, despite this, Medawar's campaign for Popper provided an embattled science community with a philosophical basis for defending pure research and the unity of basic and applied science. PMID:27017681

  20. Organochlorine and metal residues in royal terns nesting on the central Texas coast

    USGS Publications Warehouse

    King, K.A.; LeFever, C.A.; Mulhern, B.M.

    1982-01-01

    Royal Tern (Sterna maxima) eggs collected from two study areas on the central Texas coast in 1978 contained organochlorine residues at levels below those known to have adverse effects on avian reproduction and survival. Residues of zinc, copper, selenium, and arsenic were present at what appeared to be background levels. Mercury residues were elevated. Average organochlorine and metals residues did not differ significantly between an agricultural-industrial study area and a less developed control area. The thickness of eggshells collected in 1978 was statistically similar to the thickness of shells collected before 1943. There was a significant improvement in mean eggshell thickness from 1970 to 1978 with a corresponding decline in DDE and PCB residues.

  1. Purification, crystallization and preliminary X-ray diffraction analysis of royal palm tree (Roystonea regia) peroxidase.

    PubMed

    Watanabe, Leandra; Nascimento, Alessandro S; Zamorano, Laura S; Shnyrov, Valery L; Polikarpov, Igor

    2007-09-01

    Royal palm tree peroxidase (RPTP), which was isolated from Roystonea regia leaves, has an unusually high stability that makes it a promising candidate for diverse applications in industry and analytical chemistry [Caramyshev et al. (2005), Biomacromolecules, 6, 1360-1366]. Here, the purification and crystallization of this plant peroxidase and its X-ray diffraction data collection are described. RPTP crystals were obtained by the hanging-drop vapour-diffusion method and diffraction data were collected to a resolution of 2.8 A. The crystals belong to the trigonal space group P3(1)21, with unit-cell parameters a = b = 116.83, c = 92.24 A, and contain one protein molecule per asymmetric unit. The V(M) value and solvent content are 4.07 A3 Da(-1) and 69.8%, respectively.

  2. History of the Royal College of Chiropractic Sports Sciences (Canada): the early years.

    PubMed

    De Finney, John; Lawson, Gordon; Gryfe, David; Gillis-Lawson, Susan; Crawford, John P

    2016-12-01

    In 1978 the Canadian Chiropractic Association recognized the need to establish an organization that would prepare chiropractors to treat athletic injuries and promote these services to sports organizations. Dr. Adrian Grice approached three chiropractors to establish such an organization. The Canadian Chiropractic Sports Academy (CCSA) was established in 1978. This was the start of the chiropractic sports movement which has seen chiropractors playing prominent roles as team doctors to professional and amateur teams and athletes and in the delivery of care at major national and international competitions. This paper will show the work done by the original founders of the CCSA which has helped to pave the way to the present level of acceptance of chiropractic sports injury management and performance enhancement and as the progenitor of the Royal College of Chiropractic Sports Sciences Canada.

  3. Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats

    PubMed Central

    Ghanbari, Elham; Nejati, Vahid; Khazaei, Mozafar

    2016-01-01

    Background: Diabetes is the most common endocrine disease. It has adverse effects on male reproductive function. Royal Jelly (RJ) has antioxidant and anti-diabetic effects and show protective effects against diabetes. Objective: This study was conducted to evaluate the effect of RJ on histopathological alterations of the testicular tissue in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In this experimental study, 28 adult Wistar rats were randomly divided into control (C), royal jelly (R), diabetic (D) and RJ-treated diabetic (D+R) groups. Diabetes was induced by a single intraperitoneal injection of STZ at 50 mg/kg body weight (BW). The rats from the R and D+R groups received daily RJ (100 mg/kg BW) for 6 wks orally. Hematoxylin-Eosin staining was used to analyze histopathological changes including: tunica albuginea thickness (TAT), seminiferous tubules diameter (STsD), Johnsen’s score, tubular differentiation index (TDI), spermiogenesis index (SPI), Sertoli cell index (SCI), meiotic index (MI), and mononuclear immune cells (MICs) in testes. The antioxidant status was examined by evaluating testicular levels of ferric reducing antioxidant power (FRAP) and catalase (CAT) activity. Results: Histological results of the testis from diabetic rats showed significant decrease in STsD, Johnsen’s score, TDI, SPI, SCI and MI, and significant increase in TAT and MICs, while administration of RJ significantly reverted these changes (p<0.05). RJ treatment markedly increased activity of CAT and FRAP. There were significant differences in FRAP levels among C (13.0±0.5), RJ (13.4±0.3), D (7.8±0.6) and D+R (12.4±0.7) groups (p<0.05). Conclusion: RJ improved diabetes-induced impairment in testis, probably through its antioxidant property. PMID:27679827

  4. Royal jelly proteome comparison between A. mellifera ligustica and A. cerana cerana.

    PubMed

    Yu, Fang; Mao, Feng; Jianke, Li

    2010-05-07

    In this study, we compared royal jelly (RJ) produced by Apis mellifera ligustica and Apis cerana cerana in production, protein profiles, and abundances using proteomic approaches. The RJ proteome was displayed using two-dimensional gel electrophoresis (2DGE), and proteins were identified using MALDI-TOF MS and LC-Chip/ESI-QTOF MS. Differences in the RJ proteome between the two bee species were validated using western-blot analysis. RJ production by A. cerana cerana (3.21 +/- 0.43 g) is significantly lower than that of A. mellifera ligustica (80.5 +/- 7.83 g). The 2DGE based MS approach identified 52 and 60 proteins in the RJ of A. mellifera ligustica and A. cerana cerana, respectively. The majority of the identified proteins were major royal jelly proteins (MRJPs). Peroxiredoxin 2540, glutathione S-transferase S1, and MRJP5 were detected only in the RJ of A. mellifera ligustica, and MRJP1 was the most abundant MRJP. In contrast, MRJP7 was found only in the RJ of A. cerana cerana. But, similar to A. mellifera ligustica, MRJP1 was found most abundantly in this case too. In this study, glucose oxidase was identified for the first time in the A. cerana cerana RJ. Comparing the protein levels of MRJP1, 2, 3, 4, and 5 between the two species, they were significantly higher in the RJ of A. mellifera ligustica than in A. cerana cerana. This observation was supported by Western blot analysis using anti-MRJP1, 2, 3 antibodies. The result suggested that A. mellifera ligustica needs more nutrition to nurse the developing larvae and queens as compared to that of A. cerana cerana. This study improved our understanding of protein composition of RJ from Western and Eastern honeybees. RJ produced by A. mellifera ligustica exceeds the RJ from A. cerana cerana both in terms of production and health purposes.

  5. Genomic Variation of Inbreeding and Ancestry in the Remaining Two Isle Royale Wolves.

    PubMed

    Hedrick, Philip W; Kardos, Marty; Peterson, Rolf O; Vucetich, John A

    2016-12-11

    Inbreeding, relatedness, and ancestry have traditionally been estimated with pedigree information, however, molecular genomic data can provide more detailed examination of these properties. For example, pedigree information provides estimation of the expected value of these measures but molecular genomic data can estimate the realized values of these measures in individuals. Here, we generate the theoretical distribution of inbreeding, relatedness, and ancestry for the individuals in the pedigree of the Isle Royale wolves, the first examination of such variation in a wild population with a known pedigree. We use the 38 autosomes of the dog genome and their estimated map lengths in our genomic analysis. Although it is known that the remaining wolves are highly inbred, closely related, and descend from only 3 ancestors, our analyses suggest that there is significant variation in the realized inbreeding and relatedness around pedigree expectations. For example, the expected inbreeding in a hypothetical offspring from the 2 remaining wolves is 0.438 but the realized 95% genomic confidence interval is from 0.311 to 0.565. For individual chromosomes, a substantial proportion of the whole chromosomes are completely identical by descent. This examination provides a background to use when analyzing molecular genomic data for individual levels of inbreeding, relatedness, and ancestry. The level of variation in these measures is a function of the time to the common ancestor(s), the number of chromosomes, and the rate of recombination. In the Isle Royale wolf population, the few generations to a common ancestor results in the high variance in genomic inbreeding.

  6. Storage temperature and 1-MCP treatment affect storage disorders and physiological attributes of ‘Royal Gala’ apples

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Royal Gala’ apples [Malus domestica (Borkh.) Mansf.] can develop postharvest disorders such as flesh browning, senescent breakdown, peeling, cracking, or shriveling during and after cold storage. The objective of this study was to examine the effects of storage temperature and a range of 1-methylc...

  7. Simultaneous determination of trace migration of phthalate esters in honey and royal jelly by GC-MS.

    PubMed

    Zhou, Jinhui; Qi, Yitao; Wu, Hongmei; Diao, Qingyun; Tian, Feifei; Li, Yi

    2014-03-01

    A simple, rapid, and reliable liquid-liquid extraction coupled to GC-MS method was developed and validated for the quantification of 22 phthalate esters (PAEs) in honey and royal jelly. Instrument parameters for GC-MS were tested to obtain the satisfactory separation between 22 PAEs with high sensitivity. The extraction procedure was optimized in order to achieve the best recovery. The following criteria were used to validate the developed method: linearity, LOD, lower LOQ, precision, accuracy, matrix effect and carry-over. Correlation coefficients were >0.999 by applying the linear regression model based on the least-squares method with a weighting factor (1/x). The intra- and interday precision were within 12.7% in terms of RSD, and the accuracy was within -11.8% in terms of relative error. The mean extraction recoveries ranged between 80.1 and 110.9% for honey and royal jelly. No significant matrix effect and carry-over for PAEs were observed for the analysis of honey and royal jelly samples. A total of 20 real samples were analyzed for a mini-survey using the developed method. Seven PAEs in honey samples and five PAEs in royal jelly samples were found, indicating potential contamination with several PAEs.

  8. Children at Risk in School: Proceedings of a Day Conference at the Royal Commonwealth Society on Wednesday, February 5, 1975.

    ERIC Educational Resources Information Center

    National Association for the Care and Resettlement of Offenders, (England).

    This booklet consists of ther proceedings of a day conference at the Royal Commonwealth Society to explore the subject of crime prevention in relation to children in school. It is divided into several sections which speak to the following: (1) report summary of comments made by the various participants; (2) how teachers can help to combat crime;…

  9. Two Years on: Koha 3.0 in Use at the CAMLIS Library, Royal London Homoeopathic Hospital

    ERIC Educational Resources Information Center

    Bissels, Gerhard; Chandler, Andrea

    2010-01-01

    Purpose: The purpose of this paper is to describe the further development of the Koha 3.0 library management system (LMS) and the involvement of external software consultants at the Complementary and Alternative Medicine Library and Information Service (CAMLIS), Royal London Homoeopathic Hospital. Design/methodology/approach: The paper takes the…

  10. It Gets Me Upset Talking about the Royal Albert: Collaborative Analysis of the Ethics of an Oral History Project

    ERIC Educational Resources Information Center

    Mee, Steve

    2012-01-01

    An ongoing oral history project at the University of Cumbria seeks to uncover the lived experiences of people with learning difficulties who lived at the Royal Albert Hospital. A recently made video exposed the apparent distress this caused one of the participants. Ethical discussions about the project reached a point of being "stuck".…

  11. Present Practices and Background to Teaching and Learning at the Royal University of Bhutan (RUB): A Pilot Study

    ERIC Educational Resources Information Center

    Gyamtso, Deki; Maxwell, T. W.

    2012-01-01

    In Bhutan relatively few studies at the higher education level have been done and fewer still reported in international journals. This pilot study highlights the present practices and culture of teaching and learning at one of the teacher education colleges of the Royal University of Bhutan (RUB). It looks broadly across the issues of…

  12. Implementation of an Open Source Library Management System: Experiences with Koha 3.0 at the Royal London Homoeopathic Hospital

    ERIC Educational Resources Information Center

    Bissels, Gerhard

    2008-01-01

    Purpose: The purpose of this paper is to describe the selection process and criteria that led to the implementation of the Koha 3.0 library management system (LMS) at the Complementary and Alternative Medicine Library and Information Service (CAMLIS), Royal London Homoeopathic Hospital. Design/methodology/approach: The paper is a report based on…

  13. 78 FR 23316 - The Royal Bank of Scotland plc, et al.; Notice of Application and Temporary Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... ``Covered Persons'') with respect to any activity contemplated by section 9(a) of the Act. Filing Date: The... Marunouchi, Chiyoda-ku, Tokyo 100- 0005, Japan. FOR FURTHER INFORMATION CONTACT: Bruce R. MacNeil, Senior... direct or indirect wholly-owned subsidiary of The Royal Bank of Scotland Group plc (``RBSG''). RBSG...

  14. Decision support for dutch drought management and climate change with the Netherland Hydrological Modeling Instrument

    NASA Astrophysics Data System (ADS)

    Hunink, J.; Hoogewoud, J. C.; Prinsen, G.; Veldhuizen, A.

    2012-04-01

    Netherlands Hydrological Modeling Instrument Decision support for dutch drought management and climate change. J. Hunink , J.C.Hoogewoud , A. Veldhuizen , G. Prinsen , The Netherlands Hydrological modeling Instrument (NHI) is the center point of a framework of models, to coherently model the hydrological system and the multitude of functions it supports. Dutch hydrological institutes Deltares, Alterra, Netherlands Environmental Assessment Agency, RWS Waterdienst, STOWA and Vewin are cooperating in enhancing the NHI for adequate decision support. The instrument is used by three different ministries involved in national water policy matters, for instance drought management, manure policy and climate change issues. The basis of the modeling instrument is a state-of-the-art on-line coupling of the groundwater system (MODFLOW), the unsaturated zone (metaSWAP) and the surface water system (MOZART-DM). It brings together hydro(geo)logical processes from the column to the basin scale, ranging from 250x250m plots to the river Rhine and includes salt water flow. The NHI is validated with an eight year run (1998-2006) with dry and wet periods and is updated every year. During periods of water scarcity the NHI is used for operational forecasting and decision support system for the National Board of water Distribution. It provides data on nationwide calculated water demands, development of water levels in reservoirs and possible los of yield in agricultural area's. For the exploration of the future of fresh water supply in the Netherlands an extensive study is set up using the NHI. In this study different climate scenarios are being evalueated. In the first phase the focus is on describing the range of possible effects, the second phase focuses on adaptive measures and preparing for decisions how to alter the hydrological system. Results from the first phase show that in future scenario's fresh water may not be available to current water users. Important decisions about the

  15. Trace analysis of sulforaphane in bee pollen and royal jelly by liquid chromatography-tandem mass spectrometry.

    PubMed

    Ares, Ana M; Ayuso, Irene; Bernal, José L; Nozal, María J; Bernal, José

    2016-02-15

    In this study, we investigate for the first time the presence of sulforaphane (SFN) residues in two of the most currently consumed food/dietary supplements, royal jelly and bee pollen. Chromatography-tandem mass spectrometry (LC-MS/MS) was the method employed, the mass spectrometer consisting of an ion-trap mass analyzer used with electrospray ionization (ESI) in positive ion mode. An efficient sample treatment involving a solvent extraction with methanol, centrifugation, and concentration in a rotary evaporator was proposed. In all cases average analyte recoveries were between 92 and 106%. Chromatographic analysis (16min) was performed on a core-shell technology based column (Kinetex C18, 150×4.6mm, 2.6μm, 100Å). The mobile phase consisted of 0.02M ammonium formate in water and acetonitrile, with a flow rate of 0.5mL/min in gradient elution mode. The fully validated method was selective, linear from 8 to 1000μg/kg (bee pollen), or from 10 to 1250μg/kg (royal jelly), precise and accurate; relative standard deviation (% RSD) and relative error (% RE) values were below 10%. Low limits of detection (LOD) and quantification (LOQ) were obtained, namely, 3μg/kg (LOD) and 8 (bee pollen) and 10 (royal jelly) μg/kg (LOQ). The method was applied for SFN analysis in several royal jelly and bee pollen samples. SFN was detected at trace levels in some bee pollen samples (<23μg/kg) examined, whilst SFN went undetected in the royal jelly samples analyzed.

  16. The screening and scoping of Environmental Impact Assessment and Strategic Environmental Assessment of Carbon Capture and Storage in the Netherlands

    SciTech Connect

    Koornneef, J.; Faaij, A.; Turkenburg, W.

    2008-08-15

    The Environmental Impact Assessment (EIA) and Strategic Environmental Assessment (SEA) are procedural tools which have as goal to assess and evaluate possible environmental effects of, respectively, a proposed project or policy plan. The goal of this article is to explore possible bottlenecks in applying both the EIA and SEA procedures on Carbon Capture and Storage (CCS) activities in the Netherlands, as experience is currently minimal or lacking. In this study we focus mainly on the institutional and procedural aspects of the screening and scoping phases of both procedures. This is achieved by reviewing EIA and SEA procedures for analogue projects for the three distinctive process steps of a CCS project, namely the power plant with capture, the transport and finally the underground storage of the CO{sub 2}. Additionally, EIA and SEA or similar procedures on CCS in other countries are reviewed and the legal framework for the Dutch EIA and SEA is studied. This article shows a concise overview of the EIA and SEA procedure in the Netherlands and the relation between both procedures. Based on our findings we have constructed a conceptual taxonomy for the scope of both procedures for CCS in the Netherlands. This taxonomy conceptualizes the possible integration of assessing the environmental impacts for tiered levels of decision making. This integration might be needed for first CCS projects as decisions on the strategic (spatial planning) level are currently absent for CCS in the Netherlands. Perpendicular to such integration is the integration of linked activities in the CCS chain and their alternatives, into one procedure. We argue that it would be beneficial to combine the separate EIA procedures for CCS activities into one procedure or at least provide close linkage between them.

  17. Porters, watchmen, and the crime of William Sayers: the non-scientific staff of the Royal Observatory, Greenwich, in Victorian times

    NASA Astrophysics Data System (ADS)

    Chapman, Allan

    2003-06-01

    A careful study of the detailed archives of the Victorian Royal Observatory makes it possible to build up a picture of the employment and working conditions not only of the astronomical staff who worked at Greenwich, but also of the labourers, watchmen, and gate porters. Indeed, the archives open up a window on to how the Observatory was run on a daily basis: how its non-scientific staff were recruited and paid, and what were their terms of employment. They also say a great deal about how Sir George Biddell Airy directed and controlled every aspect of the Observatory's life. Yet while Airy was a strict employer, he emerges as a man who was undoubtedly fair-minded and sometimes even generous to his non-scientific work-force. A study of the Observatory staff files also reveals the relationship between the Observatory labouring staff and the Airy family's domestic servants. And of especial interest is the robbery committed by William Sayers, the Airy family footman in 1868, bringing to light as it does Sir George and Lady Richarda Airy's views on crime and its social causes and consequences, the prison rehabilitation service in 1868, and their opinions on the reform of offenders. Though this paper is not about astronomy as such, it illuminates a fascinating interface where the world of astronomical science met and worked alongside the world of ordinary Victorian people within the walls of one of the nineteenth century's most illustrious astronomical institutions.

  18. Quality assurance of medical education in the Netherlands: programme or systems accreditation?

    PubMed Central

    Hillen, Harry F. P.

    2010-01-01

    Accreditation is an instrument that is used worldwide to monitor, maintain and improve the quality of medical education. International standards have been defined to be used in reviewing and evaluating the quality of education. The organization and the process of accreditation of medical education programmes in the Netherlands and in Flanders are described in some detail. Accreditation can be based on the results of a detailed assessment of an educational programme or on an evaluation of the educational system and the organization of the institution in question. The Flemish-Dutch accreditation organization (NAO) is moving from programme accreditation towards a combination of programme and systems accreditation. The pros and cons of these two approaches are discussed. PMID:21818192

  19. The state of psychiatry in the Netherlands: strength by quality, influence by capabilities.

    PubMed

    van Schijndel, Maarten A; Gerrits, Wieneke L J; Niesink, Peter; van der Gaag, Rutger Jan

    2012-08-01

    Psychiatry and mental healthcare in the Netherlands has a long history of institutional care, slowly more adapted to the community, but differentiated from mainstream healthcare in terms of organization and remuneration. It is in a crucial phase of reconsideration. Along with harsh cuts on the budgets in healthcare, the field is in transition where training is concerned. The good news is that in fruitful cooperation the government and all spcialist parties involved in mental healthcare are on the verge of reaching an important agreement that should make mental healthcare more patient centred, affordable and accessible for those who need it. The bad news that needs serious consideration and ongoing action is that mental health problems are still highly stigmatized and that as a result the government could impose an unjust and unfair own financial contribution for users in mental care as a means of lowering the costs in the field.

  20. Institute Study Report

    NASA Technical Reports Server (NTRS)

    Whitaker, Ann; Steadman, Jackie; Little, Sally; Underwood, Debra; Blackman, Mack; Simonds, Judy

    1997-01-01

    This report documents a study conducted by the MSFC working group on Institutes in 1995 on the structure, organization and business arrangements of Institutes at a time when the agency was considering establishing science institutes. Thirteen institutes, ten science centers associated with the state of Georgia, Stanford Research Institute (SRI), and IIT Research Institute (IITRI), and general data on failed institutes were utilized to form this report. The report covers the working group's findings on institute mission, structure, director, board of directors/advisors, the working environment, research arrangements, intellectual property rights, business management, institute funding, and metrics.

  1. [From veterinarian to quality control manager. What is going to change in the Netherlands for the practicing large animal veterinarian under influence of the White Paper about food safety?].

    PubMed

    Lipman, L J A; Bijker, P G H; Snijders, J M A; Sterneberg-van der Maaten, T; van Knapen, F

    2002-03-15

    The work of farm animal practitioners will change in the coming years as a result of the White Paper on food safety. Both government and the Royal Veterinary Association of the Netherlands are working on an accreditation system for veterinarians. The veterinary practitioner is a link in the chain to achieve safe products. Where in the past emphasis was on the individual animal, it will now be on the herd or flock. The veterinarian will officially determine the health status of the farm, which in turn will play a role in the inspection procedures at the slaughterhouse. This form of farm management will become compulsory for all stockholders within the framework of the Veterinary Network for Supervision. In turn, these developments will affect the veterinary medicine curriculum. New subjects such as quality management will become increasingly important.

  2. [Vancomycin resistant enterococci in the Netherlands].

    PubMed

    Leavis, H L; Willems, R J; Mascini, E M; Vandenbroucke-Grauls, C M; Bonten, M J

    2004-05-01

    Enterococci (Enterococcus faecalis and Enterococcus faecium) are relatively avirulent enteric bacteria that usually only cause infections in immunocompromised patients. Antimicrobial treatment, however, is hampered as enterococci are intrinsically resistant to many antibiotics. For years, vancomycin was considered the last available antibiotic. Plasmid-mediated resistance against vancomycin among enterococci was first described in the nineteen-eighties and since then incidences of infection caused by vancomycin-resistant enterococci (VRE) have increased dramatically, especially in the United States. In 2000, three outbreaks of VRE occurred in hospitals in the Netherlands and a set of infection-control measures was proposed to limit further transmission. These measures were based on the simultaneous isolation of VRE from multiple patients. All three outbreaks were controlled by these measures and no new outbreaks in Dutch hospitals have been reported since then. Epidemiological studies have shown that hospital outbreaks on three continents were caused by a subpopulation of E. faecium, which is characterized by the presence of a potential virulence gene (variant esp) and resistance to amoxicillin. This 'hospital strain' of E. faecium has probably been prevalent within hospital settings for some time, but only became clinically relevant when it had acquired vancomycin-resistance. Current advice is to implement the set of infection control measures formulated in 2000, only in those patients colonized by amoxicillin-resistant VRE. The potential dangers of VRE were recently underlined by the proven transmission of the vancomycin-resistance gene from VRE to methicillin-resistant Staphylococcus aureus (MRSA) in two patients in the United States. It is in the interest of the patients that prevalence of VRE and MRSA in Dutch hospitals should be kept as low as possible.

  3. Landfill reduction experience in The Netherlands.

    PubMed

    Scharff, Heijo

    2014-11-01

    Modern waste legislation aims at resource efficiency and landfill reduction. This paper analyses more than 20 years of landfill reduction in the Netherlands. The combination of landfill regulations, landfill tax and landfill bans resulted in the desired landfill reduction, but also had negative effects. A fierce competition developed over the remaining waste to be landfilled. In 2013 the Dutch landfill industry generated €40 million of annual revenue, had €58 million annual costs and therefore incurred an annual loss of €18 million. It is not an attractive option to prematurely end business. There is a risk that Dutch landfill operators will not be able to fulfil the financial obligations for closure and aftercare. Contrary to the polluter pays principle the burden may end up with society. EU regulations prohibiting export of waste for disposal are in place. Strong differentials in landfill tax rate between nations have nevertheless resulted in transboundary shipment of waste and in non-compliance with the self-sufficiency and proximity principles. During the transformation from a disposal society to a recycling society, it is important to carefully plan required capacity and to guide the reorganisation of the landfill sector. At some point, it is no longer profitable to provide landfill services. It may be necessary for public organisations or the state to take responsibility for the continued operation of a 'safety net' in waste management. Regulations have created a financial incentive to pass on the burden of monitoring and controlling the impact of waste to future generations. To prevent this, it is necessary to revise regulations on aftercare and create incentives to actively stabilise landfills.

  4. Noise zoning around airports in the Netherlands

    NASA Astrophysics Data System (ADS)

    Evers, F. W. R.

    1980-01-01

    The situation in the Netherlands with respect to noise abatement is dominated by a steadily increasing activity both at the political and the administrative level. A new law with respect to the designation of noise zones around existing and future airports and military airfields was enacted on 1 October 1978. A comprehensive new noise nuisance act was signed by the Queen on 16 February 1979. Both laws were accepted by Parliament unanimously. This article describes the new regulations with respect to noise zoning around airports. To maintain the habitability of the environment around airports, a demarcation will be made between the interest of the people living there and those of aviation. A noise zone will be designated outside which the noise load from aircraft movements may not exceed a fixed maximum. Within this area, where a noise load above the fixed maximum is allowed, planning and building design measures will have to be taken. Although the exclusion of new housing within the noise zone is an essential element, the area will be used for other purposes by exchanging previously intended developments with those from areas outside the zone. The Minister in charge of physical planning will issue directives concerning the contents of local development plans and will indicate how such plans, once amended, should be put into effect. Termination of the use or habitation of existing buildings is possible as well as soundproofing of buildings. The costs of measures taken to prevent undesirable new developments and measures taken to improve the existing state of affairs are borne by the central government. But a charge has to be paid by the users of the airports to defray the costs.

  5. 77 FR 14733 - Purified Carboxymethylcellulose From Finland and the Netherlands: Extension of Time Limit for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE International Trade Administration Purified Carboxymethylcellulose From Finland and the Netherlands: Extension..., inter alia, purified carboxymethylcellulose from Finland and the Netherlands covering the period July...

  6. Protective effect of royal jelly on the sperm parameters and testosterone level and lipid peroxidation in adult mice treated with oxymetholone

    PubMed Central

    Zahmatkesh, Ensieh; Najafi, Gholamreza; Nejati, Vahid; Heidari, Reza

    2014-01-01

    Objectives : The aim of the present study was to evaluate protective effect of royal jelly on sperm parameters, testosterone level, and malondialdehyde (MDA) production in mice. Materials and Methods: Thirty-two adult male NMRI mice weighing 30±2 g were used. All the animals were divided into 4 groups. Control group: received saline 0.1 ml/mouse/day orally for 30 days. Royal jelly group (RJ): received royal jelly at dose of 100 mg/kg daily for 30 days orally. Oxymetholone group: the received Oxymetholone (OX) at dose of 5 mg/kg daily for 30 days orally. Royal jelly+Oxymetholone group: received royal jelly at dose of 100 mg/kg/day orally concomitant with OX administration. Sperm count, sperm motility, viability, maturity, and DNA integrity were analyzed. Furthermore, serum testosterone and MDA concentrations were determined. Results: In Oxymetholone group, sperm count, motility as well as testosterone concentration reduced significantly (p<0.05), while significant (p<0.05) increases in immature sperm, sperm with DNA damaged, and MDA concentration were announced in Oxymetholone group in comparison with control group and Royal jelly+Oxymetholone group. RJ caused partially amelioration in all of the above- mentioned parameters in Royal Jelly+Oxymetholone group. Conclusion: In conclusion, RJ may be used in combination with OX to improve OX-induced oxidative stress and male infertility. PMID:25050300

  7. Controlled Containment, Radioactive Waste Management in the Netherlands

    SciTech Connect

    Codee, H.

    2002-02-26

    All radioactive waste produced in The Netherlands is managed by COVRA, the central organization for radioactive waste. The Netherlands forms a good example of a country with a small nuclear power program which will end in the near future. However, radioisotope production, nuclear research and other industrial activities will continue to produce radioactive waste. For the small volume, but broad spectrum of radioactive waste, including TENORM, The Netherlands has developed a management system based on the principles to isolate, to control and to monitor the waste. Long term storage is an essential element of the management system and forms a necessary step in the strategy of controlled containment that will ultimately result in final removal of the waste. Since the waste will remain retrievable for long time new technologies and new disposal options can be applied when available and feasible.

  8. 76 FR 29191 - Purified Carboxymethylcellulose From Finland and the Netherlands: Continuation of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... Antidumping Duty Orders: Purified Carboxymethylcellulose from Finland, Mexico, the Netherlands and Sweden, 70... Netherlands, and Sweden: Final Results of the Expedited First Sunset Reviews of the Antidumping Duty Orders... Finland, Mexico, Netherlands and Sweden, 76 FR 27663 (May 12, 2011), and USITC Publication 4225 (May...

  9. [Aliens in the Netherlands on January 1, 1990].

    PubMed

    Van Der Erf, R F; Tas, R F

    1990-08-01

    Data on the foreign-born population living in the Netherlands are presented and analyzed. "On January 1st 1990 there were 641 thousand aliens living in the Netherlands, i.e. 4.3% of the total population. These figures only relate to people included in Dutch municipal population registers who do not possess... Dutch nationality.... The largest category of aliens on January 1st 1990 was that of the Turks (185 thousand), followed by the 11 EC-nationalities (160 thousand) and... Moroccans (144 thousand)." (SUMMARY IN ENG)

  10. Modelling moose-forest interactions under different predation scenarios at Isle Royale National Park, USA.

    PubMed

    De Jager, Nathan R; Rohweder, Jason J; Miranda, Brian R; Sturtevant, Brian R; Fox, Timothy J; Romanski, Mark C

    2017-03-06

    Loss of top predators may contribute to high ungulate population densities and chronic over-browsing of forest ecosystems. However, spatial and temporal variability in the strength of interactions between predators and ungulates occurs over scales that are much shorter than the scales over which forest communities change, making it difficult to characterize trophic cascades in forest ecosystems. We applied the LANDIS-II forest succession model and a recently developed ungulate browsing extension to model how the moose population could interact with the forest ecosystem of Isle Royale National Park, USA, under three different wolf predation scenarios. We contrasted a 100-year future without wolves (no predation) with two predation scenarios (weak = long-term average predation rates and strong = higher than average rates). Increasing predation rates led to lower peak moose population densities, lower biomass removal rates, and higher estimates of forage availability and landscape carrying capacity, especially during the first forty-years of simulations. Thereafter, moose population density was similar for all predation scenarios, but available forage biomass and the carrying capacity of the landscape continued to diverge among predation scenarios. Changes in total aboveground live biomass and species composition were most pronounced in the no and weak predation scenarios. Consistent with smaller-scale studies, high browsing rates led to reductions in the biomass of heavily browsed Populus tremuloides, Betula papyrifera, and Abies balsamea, and increases in the biomass of unbrowsed Picea glauca and P. mariana, especially after the simulation year 2050 when existing boreal hardwood stands at Isle Royale are projected to senesce. As a consequence, lower predation rates corresponded with a landscape that progressively shifted toward dominance by P. glauca and P. mariana, and lacking available forage biomass. Consistencies with previously documented small

  11. The gonadotrophic response of Royal Marines during an operational deployment in Afghanistan.

    PubMed

    Hill, N E; Woods, D R; Delves, S K; Murphy, K G; Davison, A S; Brett, S J; Quinton, R; Turner, S; Stacey, M; Allsopp, A J; Fallowfield, J L

    2015-03-01

    Military training has been associated with changes in the hypothalamic-pituitary-gonadal axis consistent with central hypogonadism. Often such changes have been associated with body mass loss, though sleep deprivation and other psychological stress may also contribute. The effects of deployment in a combat zone on the hypothalamic-pituitary-gonadal axis in military personnel are not known. The objective was to investigate the hypothalamic-pituitary-gonadal axis in male military personnel deployed in Afghanistan. Eighty-nine Royal Marines were investigated pre-deployment, following 3 months in Afghanistan and following 2 weeks mid-tour leave. Testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinising hormone (LH), 17-hydroxyprogesterone, androstenedione (AD) and insulin were assayed and body mass recorded. The results showed that body mass (kg) dropped from 83.2 ± 9.2 to 79.2 ± 8.2 kg during the first 3 months of deployment (p < 0.001). Total testosterone did not change, but SHBG increased (30.7 ± 9.7 vs. 42.3 ± 14.1 nmol/L, p < 0.001), resulting in a significant (p < 0.001) fall in calculated free testosterone (435.2 ± 138 vs. 375.1 ± 98 pmol/L). Luteinising hormone and FSH increased by 14.3% (p < 0.001) and 4.9% (p = 0.003) respectively. Free testosterone, SHBG, LH and FSH returned to baseline following 2 weeks of mid-tour leave. Androstenedione (AD) decreased by 14.5% (p = 0.024), and insulin decreased by 26% (p = 0.039), over the course of deployment. In this study of lean Royal Marines, free testosterone decreased during operational deployment to Afghanistan. There was no evidence to suggest major stress-induced central hypogonadism. We postulate that reduced body mass, accompanied by a decrease in insulin and AD synthesis, may have contributed to an elevated SHBG, leading to a decrease in free testosterone.

  12. Landfill reduction experience in The Netherlands

    SciTech Connect

    Scharff, Heijo

    2014-11-15

    Highlights: • ‘Zero waste’ initiatives never consider risks, side effects or experience of achieved low levels of landfill. • This paper provides insight into what works and what not. • Where strong gradients in regulations and tax occur between countries, waste will find its way to landfills across borders. • Strong landfill reduction can create a fierce competition over the remaining waste to be landfilled resulting in losses. • At some point a public organisation should take responsibility for the operation of a ‘safety net’ in waste management. - Abstract: Modern waste legislation aims at resource efficiency and landfill reduction. This paper analyses more than 20 years of landfill reduction in the Netherlands. The combination of landfill regulations, landfill tax and landfill bans resulted in the desired landfill reduction, but also had negative effects. A fierce competition developed over the remaining waste to be landfilled. In 2013 the Dutch landfill industry generated €40 million of annual revenue, had €58 million annual costs and therefore incurred an annual loss of €18 million. It is not an attractive option to prematurely end business. There is a risk that Dutch landfill operators will not be able to fulfil the financial obligations for closure and aftercare. Contrary to the polluter pays principle the burden may end up with society. EU regulations prohibiting export of waste for disposal are in place. Strong differentials in landfill tax rate between nations have nevertheless resulted in transboundary shipment of waste and in non-compliance with the self-sufficiency and proximity principles. During the transformation from a disposal society to a recycling society, it is important to carefully plan required capacity and to guide the reorganisation of the landfill sector. At some point, it is no longer profitable to provide landfill services. It may be necessary for public organisations or the state to take responsibility for the

  13. Theodore J. Simons 1939-1987

    NASA Astrophysics Data System (ADS)

    Murthy, Raj

    Theodore Johannes Simons was born in the Netherlands in 1939. He graduated from the Technological University of Delft, where he majored in theoretical fluid dynamics. He was subsequently associated with the North Sea Storm Surge Research of the Royal Netherlands Meteorological Institute and served as a meteorological officer in the Royal Netherlands Air Force.In 1966, Simons came to the United States as a research student at the Department of Atmospheric Science, Colorado State University (Fort Collins), where he studied atmospheric instability and numerical modeling of atmospheric development. He received his Ph.D. in 1970 for his study of the nonlinear dynamics of cyclone waves.

  14. Thomas Birch's 'Weekly Letter' (1741-66): correspondence and history in the mid-eighteenth-century Royal Society.

    PubMed

    Ellis, Markman

    2014-09-20

    Thomas Birch (1705-66), Secretary of the Royal Society from 1752 to 1765, and Philip Yorke, second Earl of Hardwicke (1720-90), wrote a 'Weekly Letter' from 1741 to 1766, an unpublished correspondence of 680 letters now housed in the British Library (Additional Mss 35396-400). The article examines the dimensions and purposes of this correspondence, an important conduit of information for the influential coterie of the 'Hardwicke circle' gathered around Yorke in the Royal Society. It explores the writers' self-conception of the correspondence, which was expressed in deliberately archaic categories of seventeenth-century news exchange, such as the newsletter, aviso and a-la-main. It shows how the letter writers negotiated their difference in status through the discourse of friendship, and concludes that the 'Weekly Letter' constituted for the correspondents a form of private knowledge, restricted in circulation to their discrete group, and as such unlike the open and networked model of Enlightenment science.

  15. Seventeenth-century experimenta, magisterial formulae and the ‘animal alkahest’: new documents found in Royal Society archives

    PubMed Central

    Alfonso-Goldfarb, Ana Maria; Ferraz, Márcia Helena Mendes; Rattansi, Piyo M.

    2015-01-01

    In this paper we present three newly rediscovered documents from the Royal Society archives that, together with the four described in our previous publications, constitute a set on a cognate theme. The documents were written by, or addressed to, members of the early Royal Society, and their subject is several magisterial formulae, including J. B. van Helmont's alkahest and Ludus. In addition to the interest in those formulae as medicines for various grave illnesses, our analysis showed that some seventeenth-century scholars sought to explain operations of the animal body by invoking similar but natural substances, while attempting to assimilate the latest anatomical discoveries into a novel framework. The complete set of documents sheds some new light on the interests of seventeenth-century networks of scholars concerned with experimenta. PMID:26665488

  16. SEVENTEENTH-CENTURY EXPERIMENTA, MAGISTERIAL FORMULAE AND THE 'ANIMAL ALKAHEST': NEW DOCUMENTS FOUND IN ROYAL SOCIETY ARCHIVES.

    PubMed

    Alfonso-Goldfarb, Ana Maria; Mendes Ferraz, Márcia Helena; Rattansi, Piyo M

    2015-12-20

    In this paper we present three newly rediscovered documents from the Royal Society archives that, together with the four described in our previous publications, constitute a set on a cognate theme. The documents were written by, or addressed to, members of the early Royal Society, and their subject is several magisterial formulae, including J. B. van Helmont's alkahest and Ludus. In addition to the interest in those formulae as medicines for various grave illnesses, our analysis showed that some seventeenth-century scholars sought to explain operations of the animal body by invoking similar but natural substances, while attempting to assimilate the latest anatomical discoveries into a novel framework. The complete set of documents sheds some new light on the interests of seventeenth-century networks of scholars concerned with experimenta.

  17. Ethanol reduces ripening of 'Royal Gala' apples stored in controlled atmosphere.

    PubMed

    Weber, Anderson; Brackmann, Auri; Both, Vanderlei; Pavanello, Elizandra P; Anese, Rogerio O; Schorr, Márcio R W

    2016-03-01

    This work aims at evaluate ethanol effect of acetaldehyde application in post-storage quality of 'Royal Gala' apples maintenance, and to compare them with consolidated storage techniques. Thus two experiments were performed during the years of 2008 and 2009. In the first experiment (2008), the application of ethanol, acetaldehyde or 1-MCP and ethylene scrubbing were tested. Fruits were stored in controlled atmosphere (CA) with 1.0kPa O2 and 2.0kPa CO2 at 0.5°C. In the second experiment (2009), the treatments tested were ethanol application combined or not with low relative humidity (LRH) and LRH alone. In this experiment, apples were stored in CA with 1.2kPa O2 + 2.5kPa CO2 at 0.5°C. After eight months of storage, 0.5 mL ethanol kg-1 apples month-1 or 0.25 mL acetaldehyde kg-1 apples month-1 increased mealiness, flesh browning, and decays incidence and reduced flesh firmness. In contrast, 0.3 mL ethanol kg-1 apples month-1, tested on second experiment, prevented fruit softening and decreased ACC oxidase activity and ethylene production. Although lower relative humidity was not efficient in maintaining post-storage quality, it enhanced the positive effect of ethanol application at 0.3 mL kg-1 apples month-1.

  18. Royal jelly prevents the progression of sarcopenia in aged mice in vivo and in vitro.

    PubMed

    Niu, Kaijun; Guo, Hui; Guo, Yinting; Ebihara, Satoru; Asada, Masanori; Ohrui, Takashi; Furukawa, Katsutoshi; Ichinose, Masakazu; Yanai, Kazuhiko; Kudo, Yukitsuka; Arai, Hiroyuki; Okazaki, Tatsuma; Nagatomi, Ryoichi

    2013-12-01

    Sarcopenia is characterized by the age-related loss of muscle mass and strength. One of the mechanisms of sarcopenia is the loss in the function and number of muscle satellite cells. Royal jelly (RJ) is a health food used worldwide. To obtain better digestion and absorption than RJ, protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to have potential pharmacological benefits such as prolonging the life span and reducing fatigue. Because these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of RJ or pRJ treatment on the skeletal muscles in an animal model using aged mice. In vivo, RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength and increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls. In vitro, using isolated satellite cells from aged mice, pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls. These findings suggest that RJ/pRJ treatment had a beneficial effect on age-related sarcopenia.

  19. Identification of the distribution of adenosine phosphates, nucleosides and nucleobases in royal jelly.

    PubMed

    Wu, Liming; Chen, Lanzhen; Selvaraj, Jonathan Nimal; Wei, Yue; Wang, Yong; Li, Yi; Zhao, Jing; Xue, Xiaofeng

    2015-04-15

    Nucleotides, nucleosides and nucleobases play a greater role in the physiological activity of organisms which are highly present in royal jelly (RJ). The objective of the present study is to develop a HPLC method to simultaneous determine nucleotides, nucleosides and nucleobases in RJ and access them in fresh and commercial RJ samples. The LOD and LOQ were 12.2-99.6 μg/L and 40.8-289.4 μg/L, respectively with nearly 100.9% recoveries. Except uric acid, all other compounds were found in RJ samples. Significant difference in the average content of compounds in fresh (2682.93 mg/kg) and commercial samples (3152.78 mg/kg) were observed. AMP, adenosine and adenine were found predominant in all the samples. Significant higher levels of ATP, ADP and AMP was seen in fresh RJ samples, and IMP, uridine, guanosine, and thymidine was seen in commercial RJ samples. The investigated compounds can be used as indexes for assessment RJ freshness and quality.

  20. The therapeutic potential of royal jelly in benign prostatic hyperplasia. Comparison with contemporary literature.

    PubMed

    Pajovic, Bogdan; Radojevic, Nemanja; Dimitrovski, Antonio; Tomovic, Savo; Vukovic, Marko

    2016-09-01

    The aim of this study is to establish the scientific benefit of royal jelly (RJ) on prostatic-specific antigen (PSA), post-void residual (PVR) volume and International Prostate Symptom Score (IPSS) in benign prostatic hyperplasia. For the study, a group of 40 men were administered 38 mg of RJ over a period of three months, their PSA values, prostate volumes and the volumes of their transitory prostate zones, PVR and IPPS values were measured at the end of the first month, and at the end of the third month. The results of this study confirm the potential of RJ in reducing PSA scores and improving IPSS values. Since the use of RJ did not lead to any significant reduction in PVR, prostate volume, or to any involution of the transitory zone, it appears that it may only affect the blood marker of prostatic hyperplasia and to improve quality-of-life (QoL) in those patients. Overall, in comparison to phytotherapy and conventional therapy, RJ had similar positive effects on QoL in patients with BPH, however it exhibited markedly better effects on reducing PSA levels in blood. The therapeutical use of RJ exhibited no side effects.

  1. 'Bio-nano interactions: new tools, insights and impacts': summary of the Royal Society discussion meeting.

    PubMed

    Lynch, Iseult; Feitshans, Ilise L; Kendall, Michaela

    2015-02-05

    Bio-nano interactions can be defined as the study of interactions between nanoscale entities and biological systems such as, but not limited to, peptides, proteins, lipids, DNA and other biomolecules, cells and cellular receptors and organisms including humans. Studying bio-nano interactions is particularly useful for understanding engineered materials that have at least one dimension in the nanoscale. Such materials may consist of discrete particles or nanostructured surfaces. Much of biology functions at the nanoscale; therefore, our ability to manipulate materials such that they are taken up at the nanoscale, and engage biological machinery in a designed and purposeful manner, opens new vistas for more efficient diagnostics, therapeutics (treatments) and tissue regeneration, so-called nanomedicine. Additionally, this ability of nanomaterials to interact with and be taken up by cells allows nanomaterials to be used as probes and tools to advance our understanding of cellular functioning. Yet, as a new technology, assessment of the safety of nanomaterials, and the applicability of existing regulatory frameworks for nanomaterials must be investigated in parallel with development of novel applications. The Royal Society meeting 'Bio-nano interactions: new tools, insights and impacts' provided an important platform for open dialogue on the current state of knowledge on these issues, bringing together scientists, industry, regulatory and legal experts to concretize existing discourse in science law and policy. This paper summarizes these discussions and the insights that emerged.

  2. Noise and sleep on board vessels in the Royal Norwegian Navy

    PubMed Central

    Sunde, Erlend; Bråtveit, Magne; Pallesen, Ståle; Moen, Bente Elisabeth

    2016-01-01

    Previous research indicates that exposure to noise during sleep can cause sleep disturbance. Seamen on board vessels are frequently exposed to noise also during sleep periods, and studies have reported sleep disturbance in this occupational group. However, studies of noise and sleep in maritime settings are few. This study's aim was to examine the associations between noise exposure during sleep, and sleep variables derived from actigraphy among seamen on board vessels in the Royal Norwegian Navy (RNoN). Data were collected on board 21 RNoN vessels, where navy seamen participated by wearing an actiwatch (actigraph), and by completing a questionnaire comprising information on gender, age, coffee drinking, nicotine use, use of medication, and workload. Noise dose meters were used to assess noise exposure inside the seamen's cabin during sleep. Eighty-three sleep periods from 68 seamen were included in the statistical analysis. Linear mixed-effects models were used to examine the association between noise exposure and the sleep variables percentage mobility during sleep and sleep efficiency, respectively. Noise exposure variables, coffee drinking status, nicotine use status, and sleeping hours explained 24.9% of the total variance in percentage mobility during sleep, and noise exposure variables explained 12.0% of the total variance in sleep efficiency. Equivalent noise level and number of noise events per hour were both associated with increased percentage mobility during sleep, and the number of noise events was associated with decreased sleep efficiency. PMID:26960785

  3. [Dentists' judgement of the complaint procedure of the Royal Dutch Dental Association].

    PubMed

    van Dam, B A F M; Gorter, R C; Eijkman, M A J; Bruers, J J M

    2015-02-01

    In 2013, to evaluate the functioning of the complaint procedure of the Royal Dutch Dental Association (KNMT), an anonymous, written survey was conducted among 955 dentists and dental specialists, for whom in the period mid-2008 to mid-2013 a complaint was handled. 413 (43%) participated in the study. 51% of them reported that the complaint was successfully mediated by the Regional Mediation Boards and the Specialist Mediation Board and 17% that the patient had withdrawn the complaint. For the remaining 32% the complaint was handled by the Central Complaint Committee, who determined that 13% was (partially) substantiated, 17% was not substantiated and 2% was settled. Generally, 79% of the dentists are (mostly) positive about the procedure of mediation, while 8% are neutral and 13% are dissatisfied about it. With regard to the complaints procedure this was 60%, 11% and 29% respectively. The judgment of the dentists about the Regional Mediation Boards and the Specialist Mediation Board and about the Central Complaints Committee is influenced by the success of the complaints procedure and by the impact of the complaint that was experienced. The emotional support of dentists during the complaints trajectory is one of the points requiring attention.

  4. Noise and sleep on board vessels in the Royal Norwegian Navy.

    PubMed

    Sunde, Erlend; Bratveit, Magne; Pallesen, Stale; Moen, Bente Elisabeth

    2016-01-01

    Previous research indicates that exposure to noise during sleep can cause sleep disturbance. Seamen on board vessels are frequently exposed to noise also during sleep periods, and studies have reported sleep disturbance in this occupational group. However, studies of noise and sleep in maritime settings are few. This study's aim was to examine the associations between noise exposure during sleep, and sleep variables derived from actigraphy among seamen on board vessels in the Royal Norwegian Navy (RNoN). Data were collected on board 21 RNoN vessels, where navy seamen participated by wearing an actiwatch (actigraph), and by completing a questionnaire comprising information on gender, age, coffee drinking, nicotine use, use of medication, and workload. Noise dose meters were used to assess noise exposure inside the seamen's cabin during sleep. Eighty-three sleep periods from 68 seamen were included in the statistical analysis. Linear mixed-effects models were used to examine the association between noise exposure and the sleep variables percentage mobility during sleep and sleep efficiency, respectively. Noise exposure variables, coffee drinking status, nicotine use status, and sleeping hours explained 24.9% of the total variance in percentage mobility during sleep, and noise exposure variables explained 12.0% of the total variance in sleep efficiency. Equivalent noise level and number of noise events per hour were both associated with increased percentage mobility during sleep, and the number of noise events was associated with decreased sleep efficiency.

  5. Effects of royal jelly supplementation on regulatory T cells in children with SLE

    PubMed Central

    Zahran, Asmaa M.; Elsayh, Khalid I.; Saad, Khaled; Eloseily, Esraa M.A.; Osman, Naglaa S.; Alblihed, Mohamd A.; Badr, Gamal; Mahmoud, Mohamed H.

    2016-01-01

    Background and objective To our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE with some immunological markers (CD4+ and CD8+ regulatory T cells and T lymphocytes apoptosis). Methods This was an open-label study in which 20 SLE children received 2 g of freshly prepared RJ daily, for 12 weeks. Results The percentages of CD4+ CD25+high FOXP3+cells (CD4+ regulatory T cells) and CD8+CD25+high FOXP3+cells (CD8+ regulatory T cells) were significantly increased after RJ treatment when compared with baseline values. Apoptotic CD4 T lymphocytes were significantly decreased after RJ therapy when compared with baseline values and the control group. Conclusion This is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this stage, it is a single study with a small number of patients, and a great deal of additional wide-scale randomized controlled studies are needed to critically validate the efficacy of RJ in SLE. PMID:27887663

  6. Age, growth, maturity, and fecundity of 'humper' lake trout, Isle Royale, Lake Superior

    USGS Publications Warehouse

    Rahrer, Jerold F.

    1965-01-01

    Humper lake trout are one of the several races or subpopulations of lake trout in Lake Superior. This study is based on 3,705 fish collected on a reef south of Isle Royale near the eastern end. The mean lengths of humper trout from commercial gill nets were smaller than those of lean lake trout. Members of age-groups VII, VIII, and IX represented 81.5 per cent of the commercial humper catch. The body-scale relation was described by two intersecting straight lines. The weight of humper trout increased as the 3.282 power of the length. Growth in length was slow and ranged from 1.6 to 3.5 inches per year. Annual increments were greatest in the first, sixth, and seventh years. Growth in weight was also slow but increased each year. Humper trout became legal (1 1/2 pounds) in the eighth year of life and reached 5 pounds in 11 years. All fish longer than 19.1 inches and older than age-group VIII were mature; the shortest mature fish were: males, 12.7 inches; females, 14.7 inches. At minimum legal size, 98 per cent of the males and 56 per cent of the females were mature. Humper trout produced an average of 1,351 eggs per fish or 516 per pound.

  7. Royal Dutch/Shell unit to start gas flow off Brazil

    SciTech Connect

    Not Available

    1992-07-20

    Pecten do Brazil, a unit of the Royal Dutch/Shell Group, plans a September start-up of Merluza, the only natural gas field discovered off Brazil by a foreign operator. This paper reports that plans call for initial production of 17.7 MMcfd from a single fixed platform in 130 m of water in the Santos basin 180 km off Sao Paulo state. Production is expected to build to 53 MMcfd 1 year later and stay at that volume for 12 years. Total investment in the project is pegged at $439 million. Although Pecten discovered and developed the field, stat oil company Petroleos Brasileiro SA earlier was scheduled to assume operator ship in spring 1992. Pecten found Merluza in 1979 and has drilled six high angle development wells. The field holds and estimated 388.5 bcf of reserves, almost 1/10 of the nation's total 4.06 tcf, plus 11 million bbl of condensate. Merluza gas will move though a 186 km, 16 in. subsea pipeline to shore at Praia Grande, Santos, where is will link with a 28 km, 16 in. pipeline to the Presidente Bernardes refinery at Cubatao, Sao Paulo State. The refinery will take some of the gas, with the rest to be distributed in Sao Paulo state by Comgas, the state's gas distribution company.

  8. Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice.

    PubMed

    Yoshida, Mei; Hayashi, Kaori; Watadani, Risa; Okano, Yoshiyasu; Tanimura, Keiya; Kotoh, Jun; Sasaki, Daiki; Matsumoto, Kozo; Maeda, Akihiko

    2017-02-14

    The study examined whether royal jelly (RJ) can prevent obesity and ameliorate hyperglycemia in type 2 diabetes. This study utilized obese/diabetic KK-Ay mice. RJ (10 mg/kg) was administered by oral gavage. Body weight, plasma glucose and insulin levels were measured. mRNA and protein levels were determined using quantitative reverse transcription polymerase chain reaction and western blotting, respectively. Four weeks of RJ administration improved hyperglycemia and partially suppressed body weight gain, although the latter effect did not reach statistical significance. In addition, RJ administration did not improve insulin resistance. RJ administration suppressed the mRNA expression of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, in the liver. Simultaneously, RJ administration induced adiponectin (AdipoQ) expression in abdominal fat, adiponectin receptor-1 (AdipoR1) expression in the liver and phosphorylated AMP-activated protein kinase (pAMPK) expression, which suppressed G6Pase levels in the livers of KK-Ay mice. pAMPK levels were also increased in skeletal muscle, but glucose transporter-4 (Glut4) translocation was not increased in the RJ supplementation group. The improvement in hyperglycemia due to long-term RJ administration may be because of the suppression of G6Pase expression through the upregulation of AdipoQ and AdipoR1 mRNA and pAMPK protein expressions.

  9. Royal College of Pathologists' United Kingdom pilot study of laboratory accreditation. The College Accreditation Steering Committee.

    PubMed

    1990-02-01

    The Royal College of Pathologists recently commissioned a pilot study to assess the feasibility, desirability, and cost of establishing a national scheme for laboratory accreditation in the United Kingdom. Using a format similar to that designed by the College of American Pathologists, eight inspectors visited 24 laboratories comprising the major disciplines of two district hospitals, two teaching hospitals, a specialised (paediatric) hospital and a private hospital. Nine were considered accreditable without reservation, but 15 had deficiencies identified of differing importance which needed to be corrected before accreditation could be awarded. Problems identified were variable, but none related to technical performance and many did not require extra resources to correct. The exercise was conducted without organisational difficulty at an approximate direct cost of 300 pounds per laboratory. The study shows that the format used could form the basis of a cost effective nationwide strategy. The type of problems identified suggest that such a strategy is more likely to succeed if it is organised from within the pathology professions.

  10. In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

    PubMed Central

    Zhang, Yan-Zheng; Zheng, Yu-Fei

    2016-01-01

    Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages. The results showed that 10-H2DA, 10-HDAA, and SEA had potent, dose-dependent inhibitory effects on the release of the major inflammatory-mediators, nitric oxide, and interleukin-10, and only SEA decreased TNF-α production. Several key inflammatory genes have also been modulated by these RJ fatty acids, with 10-H2DA showing distinct modulating effects as compared to the other two FAs. Furthermore, we found that these three FAs regulated several proteins involved in MAPK and NF-κB signaling pathways. Taken together, these findings provide additional references for using RJ against inflammatory diseases. PMID:27847405

  11. Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice

    PubMed Central

    YOSHIDA, Mei; HAYASHI, Kaori; WATADANI, Risa; OKANO, Yoshiyasu; TANIMURA, Keiya; KOTOH, Jun; SASAKI, Daiki; MATSUMOTO, Kozo; MAEDA, Akihiko

    2016-01-01

    The study examined whether royal jelly (RJ) can prevent obesity and ameliorate hyperglycemia in type 2 diabetes. This study utilized obese/diabetic KK-Ay mice. RJ (10 mg/kg) was administered by oral gavage. Body weight, plasma glucose and insulin levels were measured. mRNA and protein levels were determined using quantitative reverse transcription polymerase chain reaction and western blotting, respectively. Four weeks of RJ administration improved hyperglycemia and partially suppressed body weight gain, although the latter effect did not reach statistical significance. In addition, RJ administration did not improve insulin resistance. RJ administration suppressed the mRNA expression of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, in the liver. Simultaneously, RJ administration induced adiponectin (AdipoQ) expression in abdominal fat, adiponectin receptor-1 (AdipoR1) expression in the liver and phosphorylated AMP-activated protein kinase (pAMPK) expression, which suppressed G6Pase levels in the livers of KK-Ay mice. pAMPK levels were also increased in skeletal muscle, but glucose transporter-4 (Glut4) translocation was not increased in the RJ supplementation group. The improvement in hyperglycemia due to long-term RJ administration may be because of the suppression of G6Pase expression through the upregulation of AdipoQ and AdipoR1 mRNA and pAMPK protein expressions. PMID:27890887

  12. A retrospective analysis of deep neck infections at Royal perth hospital.

    PubMed

    Matzelle, S J; Heard, A M B; Khong, G L S; Riley, R H; Eakins, P D

    2009-07-01

    Serious deep neck infections may result in life-threatening airway complications. The aim of this study was to review the management of patients requiring surgical drainage with deep neck infections and to identify possible factors that may predict a greater risk of airway complications. In this study the authors reviewed the notes of patients requiring surgical drainage of deep neck infections who were admitted to Royal Perth Hospital over a seven-year period (2000 to 2007). One hundred and twenty-nine suitable patients were identified, of whom 15.5% encountered airway complications including one death due to airway obstruction. Airway complications were more common if there was no consultant anaesthetist present (odds ratio 4.01 [confidence interval 1.20 to 13.46], P = 0.02). Deep neck infections are still relatively common and are associated with significant morbidity and mortality. Patients with deep neck infections represent an anaesthetic challenge which should be managed by those with an appropriate level of experience.

  13. Accelerating vaccine development and deployment: report of a Royal Society satellite meeting

    PubMed Central

    Bregu, Migena; Draper, Simon J.; Hill, Adrian V. S.; Greenwood, Brian M.

    2011-01-01

    The Royal Society convened a meeting on the 17th and 18th November 2010 to review the current ways in which vaccines are developed and deployed, and to make recommendations as to how each of these processes might be accelerated. The meeting brought together academics, industry representatives, research sponsors, regulators, government advisors and representatives of international public health agencies from a broad geographical background. Discussions were held under Chatham House rules. High-throughput screening of new vaccine antigens and candidates was seen as a driving force for vaccine discovery. Multi-stakeholder, small-scale manufacturing facilities capable of rapid production of clinical grade vaccines are currently too few and need to be expanded. In both the human and veterinary areas, there is a need for tiered regulatory standards, differentially tailored for experimental and commercial vaccines, to allow accelerated vaccine efficacy testing. Improved cross-fertilization of knowledge between industry and academia, and between human and veterinary vaccine developers, could lead to more rapid application of promising approaches and technologies to new product development. Identification of best-practices and development of checklists for product development plans and implementation programmes were seen as low-cost opportunities to shorten the timeline for vaccine progression from the laboratory bench to the people who need it. PMID:21893549

  14. Royal Jelly alleviates sperm toxicity and improves in vitro fertilization outcome in Stanozolol-treated mice

    PubMed Central

    Shalizar Jalali, Ali; Najafi, Gholamreza; Hosseinchi, Mohammadreza; Sedighnia, Ashkan

    2015-01-01

    Background: Stanozolol (ST) is a synthetic anabolic-androgenic steroid often abused by athletes. An increasing body of evidence points towards the role of ST misuses in the pathogenesis of a wide range of adverse effects including reprotoxicity. Objective: The aim of this study was to analyze the possible reproprotective effect of royal jelly (RJ) as an efficient antioxidant in ST-treated mice. Materials and Methods: Adult male mice were divided into four groups (n=5). Two groups of mice received ST (4.6 mg/kg/day) via gavage for 35 days. RJ was given orally to one of these groups at the dose level of 100 mg/kg body weight per day synchronously. Untreated control group and RJ-only treated group were also included. Epididymal sperm characteristics and in vitro fertilizing capacity were evaluated after 35 days. Results: ST treatment caused a significant (p<0.05) decrease in sperm count and motility and fertilization rate along with poor blastocyst formation and increased sperm DNA damage. Moreover, the incidence of apoptosis and abnormality in spermatozoa was significantly (p<0.05) higher in ST-exposed mice than those of control. The above-mentioned parameters were restored to near normal level by RJ co-administration. Conclusion: Data from the current study suggest that RJ has a potential repro-protective action against ST-induced reproductive toxicity in mice. However, clinical studies are warranted to investigate such an effect in human subjects. PMID:25653671

  15. Hatchability rate and embryonic growth of broiler chicks following in ovo injection royal jelly.

    PubMed

    Moghaddam, A A; Borji, M; Komazani, D

    2014-01-01

    1. The objectives of this study were to compare the hatchability, chick body and internal organs weights and plasma testosterone concentration of hatchlings after in ovo administration of royal jelly (RJ) on d 7 of incubation. 2. Fertile eggs (n = 150) were injected into the air sac or yolk sac with 0.5 ml normal saline solution or normal saline and pure RJ. The eggs were randomly divided into 5 groups of 30 eggs each: NC, control eggs receiving no injection; ASA, air sac-injected eggs given normal saline solution; ARJ, air sac-injected eggs injected with pure RJ; YSA, yolk sac-injected eggs receiving normal saline solution and YRJ, yolk sac-injected eggs given pure RJ. 3. Injection of RJ significantly decreased hatchability (46.7%) compared with injection of saline solution (68.3%). Hatchability was lower in ARJ (33.3 %) and YRJ (60.0%) groups than in the NC group (90.0%). Hatchability in ASA (70.0%) and YSA (66.66%) groups were comparable to the NC group. 4. In ovo injection of RJ into both sacs increased chicks' absolute and relative body, heart, liver and testes weights compared to the control group whereas plasma testosterone concentration was similar among the different groups. 5. It was concluded that in ovo injection of RJ may be an effective method to increase the body weight of hatched chicks as an absolute value (CWT) and chicks' internal organ weights.

  16. Protective Effects of Royal Jelly on Oxymetholone- Induced Liver Injury in Mice

    PubMed Central

    Nejati, Vahid; Zahmatkesh, Ensieh; Babaei, Mohammad

    2016-01-01

    Background: The present study was carried out to investigate the possible protective effects of royal jelly (RJ) on oxymetholone (OXM)-induced oxidative liver injuries in mice. Methods: In total, 32 adult male NMRI mice were divided into four groups of eight mice each. Mice in groups 1 and 2 were orally administered 5 mg/kg/day OXM for 30 days. At the same time, mice in group 3 received RJ at a dose of 100 mg/kg/day. Saline control and RJ control groups were also included in this study. Results: Administration of 5 mg/kg OXM resulted in a significant decrease in total antioxidant capacity and catalase activity, as well as a significant increase in malondialdehyde (P<0.05). In addition, OXM-administrated mice showed a slight increase in liver enzymes, including alanine amino transferase, aspartate amino transferase, and alkaline phosphatase. Although OXM caused histopathological changes in the liver, RJ could significantly improve all of the above-mentioned parameters at a dose of 100 mg/kg. Conclusion: The results of the present study indicated that RJ has a partially protective effect on OXM-induced liver toxicity in mice. PMID:27178489

  17. The Effects of Royal Jelly on Fitness Traits and Gene Expression in Drosophila melanogaster.

    PubMed

    Shorter, John R; Geisz, Matthew; Özsoy, Ergi; Magwire, Michael M; Carbone, Mary Anna; Mackay, Trudy F C

    2015-01-01

    Royal Jelly (RJ) is a product made by honey bee workers and is required for queen differentiation and accompanying changes in queen body size, development time, lifespan and reproductive output relative to workers. Previous studies have reported similar changes in Drosophila melanogaster in response to RJ. Here, we quantified viability, development time, body size, productivity, lifespan and genome wide transcript abundance of D. melanogaster reared on standard culture medium supplemented with increasing concentrations of RJ. We found that lower concentrations of RJ do induce significant differences in body size in both sexes; higher concentrations reduce size, increase mortality, shorten lifespan and reduce productivity. Increased concentrations of RJ also consistently lengthened development time in both sexes. RJ is associated with changes in expression of 1,581 probe sets assessed using Affymetrix Drosophila 2.0 microarrays, which were enriched for genes associated with metabolism and amino acid degradation. The transcriptional changes are consistent with alterations in cellular processes to cope with excess nutrients provided by RJ, including biosynthesis and detoxification, which might contribute to accelerated senescence and reduced lifespan.

  18. "Inhumanly brought back to life and misery": Mary Wollstonecraft, Frankenstein, and the Royal Humane Society.

    PubMed

    Williams, C

    2001-01-01

    While thorough investigation of many aspects of contemporary scientific developments and Mary Shelley's personal history have provided illuminating contexts for the study of Frankenstein, the activities of the Royal Humane Society, and other bodies and individuals who pioneered and publicized resuscitation techniques, have been comparatively neglected. Here we find a richly documented, highly conspicuous area of scientific endeavour, which generated much excitement in life and literature from the last quarter of the eighteenth century onwards. There are three major points of contact with Frankenstein: Victor Frankenstein's revival of dead tissue to make his creature; the frequent occurrences of unconsciousness and asphyxia, both in the novel and in Mary Shelley's family during the period leading up to its composition, and the widely differing degrees of competence and success with which they are treated; and the possibility that resuscitative techniques were used to revive Mary Shelley's mother, Mary Wollstonecraft, after a suicide attempt. The impact on Frankenstein of Mary Shelley's lifelong distress at the role she played in bringing about her mother's death in childbirth has been thoroughly canvassed by other critics, notably Anne Mellor, but the thought that Mary Shelley, who was herself conceived after her mother's second suicide attempt, might be, in a sense, a child of the dead adds a further turn to the Gothic screw. This study traces a hitherto unexplored intersection between Mary Shelley's first novel and her family history, as well as showing how it launches a formidable attack on the shady ethics and inconsiderate arrogance of some early resuscitators.

  19. An evaluation of camping impacts and their management at Isle Royale National Park

    USGS Publications Warehouse

    Farrell, T.A.; Marion, J.L.

    1998-01-01

    Results from the development and application of a monitoring program to assess visitor impacts on back-country campsites at Isle Royale National Park are presented. Survey staff assessed conditions on 244 sites within 36 back-country campgrounds, including 113 individual campsites, 43 group campsites, and 88 shelters. Site conditions are generally quite good. Site size and other areal measures of disturbance are exceptionally small attributed to the placement of most sites on cut-and-fill constructed ?benches? within sloping terrain. Relational analyses revealed that campsites in Spruce and Fir forests and under more open forest canopies have significantly lower areal measures of disturbance. Areal disturbance is also reduced on sites where shelters and picnic tables are present, suggesting that these facilities act to concentrate visitor use. Site locational attributes, such as intersite visibility and proximity to trails, indicate a low potential for solitude within some campgrounds. Recommendations regarding site number, distribution, arrangement, facilities, maintenance, and monitoring are offered for management consideration.

  20. +GZ-induced neck injuries in Royal Australian Air Force fighter pilots.

    PubMed

    Newman, D G

    1997-06-01

    +GZ-induced neck injuries are a relatively common occurrence in pilots of high performance fighter aircraft. We surveyed 52 fighter pilots from the Royal Australian Air Force Base at Williamtown via an anonymous questionnaire in order to determine the prevalence and operational significance of these injuries. The pilots flew either the F/A-18 Hornet or the MB326H Macchi. Of the respondents, 44 reported having had a neck injury under +GZ. A higher rate was reported in pilots of the F/A-18. Most of these injuries were simple muscle sprains. There were 20 pilots who reported their neck injury as having interfered with mission completion. Only 12 pilots reported doing any regular neck strengthening exercises, while 33 pilots reported doing preflight neck stretches immediately prior to high +GZ exposure. There were 14 pilots who sought medical attention for their injury, with 9 being taken off flight status for an average of 2 weeks. Air combat maneuvering sorties and the "check six" head position were identified as causal factors by most pilots. This study demonstrates the operational significance of these injuries, and highlights the need for more research into this important aerospace medicine issue.

  1. William Brouncker MD Viscount Castlelyons (c 1620-84) First President of the Royal Society.

    PubMed

    Breathnach, Caoimhghín S

    2006-11-01

    William Brouncker was the grandson of Sir Henry Brouncker, President of Munster during the Elizabethan Plantation of Ireland in the 16th century. William's date and place of birth are uncertain; he was born about 1620, most probably at Castlelyons, County Cork, and educated at Oxford where he shone in mathematics and languages. Until his death in 1684 he served the Stuarts as a senior member of the Navy Board from which sprang the Admiralty, and we owe much of what we know about his life to the warts-and-all diary of his younger naval colleague, Samuel Pepys (1633-1703). Although William was granted a doctorate in medicine by Oxford in 1646, music and mathematics were his major interests. He was the first President of the Royal Society and he held that position from 1662 to 1677, when his tenure was brought to a reluctant close by an election, sardonically recorded in the diary of the curator of experiments, Robert Hooke (1635-1703). If Brouncker did not add any empirical facts, he certainly contributed to the promotion and dissemination of natural knowledge.

  2. The Ripley Scroll of the Royal College of Physicians of Edinburgh.

    PubMed

    McCallum, R I

    1996-01-01

    Alchemical scrolls associated with George Ripley are unusual documents which illustrate the pursuit of the Philosophers Stone. Scrolls vary from about 5 feet in length by 5 inches wide to over 20 feet long and about 3 feet wide. There are 16 scrolls in libraries in the UK and 4 in the USA. Ripley whose name is attached to the scrolls was a Canon of Bridlington in Yorkshire and lived from about 1415 to 1495. He is renowned as an alchemist and author of alchemical works in rhyme, and his verses are used on the scrolls. Some of the scrolls were produced in the 16th century, in Lübeck, probably at the request of John Dee the Elizabethan polymath. A Ripley scroll is in the library of the Royal College of Physicians of Edinburgh to which it was presented in 1707. The only published description of this scroll appeared in 1876, and it has not apparently been studied since. Interest in Ripley scrolls has grown in recent years and there have been a number of publications describing them since 1990. The Edinburgh scroll is described and is compared with the other scrolls which have been seen personally or for which detailed descriptions have been published. The origin, significance and use of Ripley Scrolls are discussed in an attempt to define their contemporary role.

  3. Management of neck pain in Royal Australian Air Force fast jet aircrew.

    PubMed

    Netto, Kevin; Hampson, Gregory; Oppermann, Brett; Carstairs, Greg; Aisbett, Brad

    2011-01-01

    To examine the type and effectiveness of various strategies used by Royal Australian Air Force (RAAF) fast jet (FJ) aircrew in self-referral and management of flight-related neck pain, a 6-section, 18-question survey tool was distributed to 86 eligible RAAF aircrew. Selective results from the sections evaluating aircrew demographics, incidence of flight-related neck pain, and the self-referral strategies of aircrew to manage these injuries are presented here. Eighty-two RAAF FJ aircrew responded to the survey. Ninety-five percent of the respondents experienced flight-related neck pain. The most commonly sought treatment modalities were on-base medical and physiotherapy services. Many respondents reported that currently provided on-base treatment and ancillary services such as chiropractic therapy are the most effective in alleviating symptoms. Further investigation into the effectiveness and safety of these ancillary therapies needs to be performed to allow appropriate consideration of their place in the management of neck pain in FJ aircrew.

  4. Conservation of Stone Cladding on the FAÇADE of Royal Palace in Caserta

    NASA Astrophysics Data System (ADS)

    Titomanlio, I.

    2013-07-01

    The beauty of cultural heritage and monumental architecture, is often linked to their non-structural elements and decorative stones façades cladding. The collapse of these elements causes significant consequences that interest the social, the economic, the historical and the technical fields. Several regulatory documents and literature studies contain methods to address the question of relief and of the risk analysis and due to the non - structural stones security. Among the references are widespread international regulatory documents prepared by the Federal Emergency Management Agency of the United States by Applied Technology Council and California. In Italy there are some indications contained in the Norme Tecniche per le Costruzioni and the Direttiva del Presidente del Consiglio dei Ministri in 2007, finalize to the reduction of seismic risk assessment of cultural heritage. The paper, using normative references and scientific researches, allows to analyze on Royal Palace of Caserta the safety and the preservation of cultural heritage and the vulnerability of non-structural stones façade cladding. Using sophisticated equipments of Laboratory ARS of the Second University of Naples, it was possible to analyze the collapse of stone elements due to degradation caused by natural phenomena of deterioration (age of the building, type of materials, geometries , mode of fixing of the elements themselves). The paper explains the collapse mechanisms of stones façade cladding of Luigi Vanvitelli Palace.

  5. Physiological, biochemical, and psychological responses to environmental survival training in the Royal Australian Air Force.

    PubMed

    Chester, Annalise L; Edwards, Andrew M; Crowe, Melissa; Quirk, Frances

    2013-07-01

    Military environmental survival training (EST) is designed and considered to evoke significant stressors to military personnel in preparation for combat-like scenarios. The aim of this study was to observe and report selected physiological, biochemical, psychological, and performance responses to this intense 15-day program of Royal Australian Air Force (RAAF) EST. Fourteen RAAF participants undertook the EST course. Physiological and psychological responses were collected across the 15 days across outcomes: (1) biochemical markers (blood lactate, interlukin-6, and creatine kinase), (2) performance and anthropometric indices (vertical jump, body mass), and (3) psychological questionnaires profile of mood states, depression anxiety stress scale, Kessler-10 etc.). Creatine kinase concentration increased significantly from baseline to day 5 (p < 0.05) and thereafter remained elevated for the remaining 10 days of EST (128%; p < 0.01). Vertical jump (-10%; p < 0.01) and body mass (-8%; p < 0.01) both decreased across 15 days of EST, while there were no significant change in interlukin-6. Negative psychological responses were observed for mood (p < 0.01), depression (p < 0.05), anxiety (p < 0.01), and stress (p < 0.01) following the EST course. This case study showed the RAAF EST course imposed significant physiological and psychological stress as observed from markers of muscle damage, deterioration in physical performance, substantial weight loss, negative mood, and psychological distress.

  6. Apparent 85Kr ages of groundwater within the Royal watershed, Maine, USA.

    PubMed

    Sidle, W C

    2006-01-01

    Specific 85Kr activity is mapped from 264 domestic and municipal wells sampled during 2002-2004 in the Royal watershed (361 km2), Maine. Gas samples are collected at 20 m, 40 m, and > 50 m interval depths within the unconfined aquifers. Gas extraction for 85Kr from wells is obtained directly via a wellhead methodology avoiding conventional collection of large sample volumes. Atmospheric 85Kr input to the recharge environment is estimated at 1.27 Bq m(-3) by time-series analyses of weighted monthly precipitation (2001-2004). Numerical simulation of Kr gas transport through the variable unsaturated zones to the water table suggests up to 12-year time lags locally, thus biasing the 85Kr groundwater ages. Apparent 85Kr ages suggest that approximately 70% of groundwater near 20 m depth was recharged less than 30 years BP (2004). Mass-age transport modeling suggests that post mid-1950s recharge penetrates to part of the basin's floor and that older groundwater seeps from the underlying fractured bedrock may occur.

  7. Longevity extension of worker honey bees (Apis mellifera) by royal jelly: optimal dose and active ingredient

    PubMed Central

    Han, Mingfeng

    2017-01-01

    In the Western honey bee, Apis mellifera, queens and workers have different longevity although they share the same genome. Queens consume royal jelly (RJ) as the main food throughout their life, including as adults, but workers only eat worker jelly when they are larvae less than 3 days old. In order to explore the effect of RJ and the components affecting longevity of worker honey bees, we first determined the optimal dose for prolonging longevity of workers as 4% RJ in 50% sucrose solution, and developed a method of obtaining long lived workers. We then compared the effects of longevity extension by RJ 4% with bee-collected pollen from rapeseed (Brassica napus). Lastly, we determined that a water soluble RJ protein obtained by precipitation with 60% ammonium sulfate (RJP60) contained the main component for longevity extension after comparing the effects of RJ crude protein extract (RJCP), RJP30 (obtained by precipitation with 30% ammonium sulfate), and RJ ethanol extract (RJEE). Understanding what regulates worker longevity has potential to help increase colony productivity and improve crop pollination efficiency. PMID:28367370

  8. Tele-pharmacy in remote medical practice: the Royal Flying Doctor Service Medical Chest Program.

    PubMed

    Margolis, S A; Ypinazar, V A

    2008-01-01

    In recent times remote medical practice has been developed into a unique discipline in its own right with telehealth one of the eight defining key features. Since 1942, the telemedicine consultation service provided by the Royal Flying Doctor Service in Australia has been supported by a tele-pharmacy program known as the Medical Chest Program. The contents of the chest comprise more than 85 items, including medications and equipment which can be prescribed during a telehealth consultation to cover both emergency care and definitive treatment for less serious conditions. By 2006 there were 3500 medical chests placed throughout Australia. Specifically, the state of Queensland had 21 470 telehealth consultations from 1 July 2005 to 30 June 2006, resulting in the prescription of at least one medical chest item in 2938 (13.7%) consultations. Queensland data regarding medication indicate that antibiotics (26%), analgesics (23%) and gastrointestinal medications (12%) were the most common categories of dispensed medications, and that the most common clinical diagnostic categories for the consultation resulting in dispensed medications were respiratory (17%), skin (15%) and abdominal conditions (13%). In summary, the RFDS medical chest program continues to be a successful large scale provider of medications to those living in remote Australia, enabling early access to medications for both emergencies and definitive care, while minimising the need for mail-order pharmacy or patient travel. This model of care may provide an important template for those designing service delivery models in other remote jurisdictions.

  9. Making public ahead of print: Meetings and publications at the Royal Society, 1752–1892

    PubMed Central

    Fyfe, Aileen; Moxham, Noah

    2016-01-01

    This essay examines the interplay between the meetings and publications of learned scientific societies during the eighteenth and nineteenth centuries, when journals were an established but not yet dominant form of scholarly communication. The ‘making public’ of research at meetings, long before actual ‘publication’ in society periodicals, enabled a complex of more or less formal sites of communication and discussion ahead of print. Using two case studies from the Royal Society of London—Jan Ingen-Housz in 1782 and John Tyndall in 1857 to 1858—we reveal how different individuals navigated and exploited the power structures, social activities and seasonal rhythms of learned societies, all necessary precursors to gaining admission to the editorial processes of society journals, and trace the shifting significance of meetings in the increasingly competitive and diverse realm of Victorian scientific publishing. We conclude by reflecting on the implications of these historical perspectives for current discussions of the ‘ends’ of the scientific journal.

  10. A review of the (60)Co internal dosimetry at Devonport Royal Dockyard.

    PubMed

    Vickers, J M A; Collison, R; Collision, R

    2010-03-01

    The physico-chemical properties of (60)Co contaminants arising from the UK Naval Nuclear Propulsion Programme (NNPP) pressurised water reactor (PWR) plants have been investigated in order to review individual monitoring requirements at Devonport Royal Dockyard (DRD). This has been achieved through laboratory tests on NNPP primary component samples and interpretation of direct bioassay measurements using internal dosimetry modelling software. Interpretation of lung measurements was completed for two inhalation events involving material originating from a PWR plant and post-primary circuit decontamination. Initial estimates of intake and dose were calculated using International Commission on Radiological Protection default parameter values. However, a good fit could only be achieved by fitting the data to alternative absorption parameters where 90-95% of the material dissolved and absorbed rapidly at a rate of 1 day(-1). As a consequence of this review, a number of improvements have been made to monitoring arrangements at DRD. A minimum of three direct measurements are now taken during the 0-30 day period after an intake, the capability of the Canberra Accuscan has been enhanced and dissolution tests are being carried out by the Health Protection Agency (HPA) on samples taken from PWR plants.

  11. Estrogenic Activities of Fatty Acids and a Sterol Isolated from Royal Jelly

    PubMed Central

    Isohama, Yoichiro; Maruyama, Hiroe; Yamada, Yayoi; Narita, Yukio; Ohta, Shozo; Araki, Yoko; Miyata, Takeshi; Mishima, Satoshi

    2008-01-01

    We have previously reported that royal jelly (RJ) from honeybees (Apis mellifera) has weak estrogenic activity mediated by interaction with estrogen receptors that leads to changes in gene expression and cell proliferation. In this study, we isolated four compounds from RJ that exhibit estrogenic activity as evaluated by a ligand-binding assay for the estrogen receptor (ER) β. These compounds were identified as 10-hydroxy-trans-2-decenoic acid, 10-hydroxydecanoic acid, trans-2-decenoic acid and 24-methylenecholesterol. All these compounds inhibited binding of 17β-estradiol to ERβ, although more weakly than diethylstilbestrol or phytoestrogens. However, these compounds had little or no effect on the binding of 17β-estradiol to ERα. Expression assays suggested that these compounds activated ER, as evidenced by enhanced transcription of a reporter gene containing an estrogen-responsive element. Treatment of MCF-7 cells with these compounds enhanced their proliferation, but concomitant treatment with tamoxifen blocked this effect. Exposure of immature rats to these compounds by subcutaneous injection induced mild hypertrophy of the luminal epithelium of the uterus, but was not associated with an increase in uterine weight. These findings provide evidence that these compounds contribute to the estrogenic effect of RJ. PMID:18830443

  12. Longevity extension of worker honey bees (Apis mellifera) by royal jelly: optimal dose and active ingredient.

    PubMed

    Yang, Wenchao; Tian, Yuanyuan; Han, Mingfeng; Miao, Xiaoqing

    2017-01-01

    In the Western honey bee, Apis mellifera, queens and workers have different longevity although they share the same genome. Queens consume royal jelly (RJ) as the main food throughout their life, including as adults, but workers only eat worker jelly when they are larvae less than 3 days old. In order to explore the effect of RJ and the components affecting longevity of worker honey bees, we first determined the optimal dose for prolonging longevity of workers as 4% RJ in 50% sucrose solution, and developed a method of obtaining long lived workers. We then compared the effects of longevity extension by RJ 4% with bee-collected pollen from rapeseed (Brassica napus). Lastly, we determined that a water soluble RJ protein obtained by precipitation with 60% ammonium sulfate (RJP60) contained the main component for longevity extension after comparing the effects of RJ crude protein extract (RJCP), RJP30 (obtained by precipitation with 30% ammonium sulfate), and RJ ethanol extract (RJEE). Understanding what regulates worker longevity has potential to help increase colony productivity and improve crop pollination efficiency.

  13. Long-term treatment with royal jelly improves bleomycin-induced pulmonary fibrosis in rats.

    PubMed

    Zargar, Hamid Reza; Hemmati, Ali Asghar; Ghafourian, Mehri; Arzi, Ardeshir; Rezaie, Anahita; Javad-Moosavi, Seyed Ali

    2017-01-01

    This study investigated the anti-fibrotic potential of royal jelly (RJ) powder against bleomycin-induced pulmonary fibrosis in rats. The rats were given RJ orally (25, 50, and 100 mg/kg per day) for 7 consecutive days before the administration of single intratracheal instillation of bleomycin (BLM) at 7.5 IU/kg. RJ doses were continued for 21 days after BLM exposure. Fibrotic changes in the lungs were studied by cell count and analysis of cytokine levels in the bronchoalveolar lavage fluid (BALF), histopathological examination, and assaying oxidative stress biomarkers in lung tissue. The results showed that BLM administration significantly increased the fibrotic changes, collagen content, and levels of malondialdehyde and decreased total thiol and glutathione peroxidase antioxidant contents in the rats' lung tissue. An increase in the level of cell counts and pro-inflammatory and pro-fibrotic cytokines such as TNF-α and TGF-β in BALF was observed. Also, it significantly decreased IFN-γ, an anti-fibrotic cytokine, in BALF. However, RJ (50 and 100 mg/kg) reversed all of these biochemical indices as well as histopathological alterations induced by BLM. The present study demonstrates that RJ, by its antioxidant and anti-inflammatory properties, attenuates oxidative damage and fibrosis induced by BLM.

  14. Healthcare coverage for undocumented migrants in Spain: Regional differences after Royal Decree Law 16/2012.

    PubMed

    Cimas, Marta; Gullon, Pedro; Aguilera, Eva; Meyer, Stefan; Freire, José Manuel; Perez-Gomez, Beatriz

    2016-04-01

    The economic crisis has prompted the debate on how to regulate health coverage of undocumented migrants in publicly funded healthcare systems. Spain, as one of the most heavily affected countries in Europe, can be considered a case of particular interest. In 2012 the Spanish Government issued a Royal Decree Law (RDL 16/2012) which revoked their previous full right to public healthcare coverage, now limited for some exceptions. However, the Spanish National Health System is highly decentralized, and this Central Government decree had to be implemented by the Regional Health Authorities. Our aim is to compare regional policies regarding entitlement to healthcare for undocumented migrants after RDL 16/2012 in the 17 Autonomous Regions by performing an exhaustive review of the regional health policy regulations published after the enactment of RDL 16/2012. Our analysis shows that many Regions adopted legal, legislative and administrative actions to void or limit its effects, while others applied it as intended, resulting in huge differences in healthcare coverage for irregular migrants among Spanish Regions. The unequal implementation of this Law constitutes a paradigmatic example of the complexity of nation-wide regulation of controversial key issues in decentralized health systems. In addition, our results highlight that within-country differences in access and/or entitlement can be as relevant as those reported among-country when there is healthcare decentralization.

  15. A small collection of sunspot drawings made in the Royal Astronomical Observatory of the Spanish Navy in 1884

    NASA Astrophysics Data System (ADS)

    Galaviz, P.; Vaquero, J. M.; Gallego, M. C.; Sánchez-Bajo, F.

    2016-12-01

    In this paper we analyze a small collection of sunspot drawings made at the Astronomical Observatory of the Spanish Navy in the period from April 1, 1884 to August 18, 1884. We calculate the area and the heliographic coordinates of the observed sunspots. From these coordinates, we obtain the solar rotation rate in this period. Finally, we compare our results with the data recorded by the Royal Greenwich Observatory.

  16. Efficacy of bayer suspend poly zone against stable flies and house flies when applied to trigger royal cloth

    Technology Transfer Automated Retrieval System (TEKTRAN)

    METHODS: PolyZone (PZ)(Deltamethrin 4.75% AI) was mixed with water according to label instructions (45.4 ml per 3.79 liters H2O = 0.06% solution) for application to 10 x 10 cm squares of blue Trigger-Royal Box fabric (65% polyester and 35% cotton, Galey & Lord, Inc., New York). PZ was applied to run...

  17. Age, growth, and maturity of round whitefish of the Apostle Islands and Isle Royale Regions, Lake Superior

    USGS Publications Warehouse

    Bailey, Merryll M.

    1963-01-01

    The round whitefish has been of some commercial importance in the upper Great Lakes but production in Lake Superior has generally been small; the United States average was 26,600 pounds for 1929-59. This study is based on 1,173 fish collected in the Apostle Islands in 1958-60 and 103 collected at Isle Royale in 1958 and 1960. The average age of 6.0 years at Isle Royale was concluded to be significantly higher than the mean of 4.2 years in the Apostle Islands. The body-scale relation is a straight line with an intercept of 1.1 inches on the length axis. Weight of Apostle Islands round whitefish captured in several months increased as the 3.22 power of the length. Growth in length was relatively slow; nearly or fully 7 years were required to reach an acceptable commercial length of 14 inches in both the Apostle Islands and at Isle Royale. The calculated weights at the end of the seventh year were 12.6 ounces in the Apostle Islands and 13.8 ounces at Isle Royale. Minimum length at maturity of male round whitefish (7.0-7.4 inches) was less than that of females (8.5-8.9 inches). At age-group II, 11.1 percent of male round whitefish, but only 1.5 percent of the females were mature. All males were mature as age-group V and all females as age-group VI. Males dominated the younger age groups but females were more numerous in the older ones. Estimates of the number of eggs in 37 round whitefish ovaries yielded an average of 5,330 eggs for fish 10.5-17.4 inches long.

  18. Improving Royal Australian Air Force Strategic Airlift Planning by Application of a Computer Based Management Information System

    DTIC Science & Technology

    1991-12-01

    perceived ability of system to support organisational goals and objectives. Other: With what other informtion systems should commaications be considered... informtion system ? A system is not required or justified. Potential exists for a system but not right now. A system may be justified. However, the envirornet...IMPROVING ROYAL AUSTRALIAN AIR FORCE STRATEGIC AIRLIFT PLANNING BY APPLICATION OF A (XM E BASED MANAGEEN INFORMATION SYSTEM THESIS Neil A. Cooper Squadron

  19. The New Microbiology: a conference at the Institut de France.

    PubMed

    Radoshevich, Lilliana; Bierne, Hélène; Ribet, David; Cossart, Pascale

    2012-08-01

    In May 2012, three European Academies held a conference on the present and future of microbiology. The conference, entitled "The New Microbiology", was a joint effort of the French Académie des sciences, of the German National Academy of Sciences Leopoldina and of the British Royal Society. The organizers - Pascale Cossart and Philippe Sansonetti from the "Académie des sciences", David Holden and Richard Moxon from the "Royal Society", and Jörg Hacker and Jürgen Hesseman from the "Leopoldina Nationale Akademie der Wissenschaften" - wanted to highlight the current renaissance in the field of microbiology mostly due to the advent of technological developments and allowing for single-cell analysis, rapid and inexpensive genome-wide comparisons, sophisticated microscopy and quantitative large-scale studies of RNA regulation and proteomics. The conference took place in the historical Palais de l'Institut de France in Paris with the strong support of Jean-François Bach, Secrétaire Perpétuel of the Académie des sciences.

  20. Delta Project Planning and Implementation in the Netherlands.

    ERIC Educational Resources Information Center

    Dutt, Ashok K.; Heal, Stephen

    1979-01-01

    Describes a water management project in the Netherlands which is intended to protect the people, land, and property in the Delta Region from abnormally high floods. Presents background for initiation of the Delta Project and discusses problems encountered in the project to date. (Author/DB)

  1. Initiative for Transformative Sustainability Education at Wageningen University, The Netherlands

    ERIC Educational Resources Information Center

    Wals, Arjen E. J.

    2011-01-01

    In this article, the author talks about a student-initiated Initiative for Transformative Sustainability Education (ITSE) at Wageningen University in The Netherlands which has led to the development of an undergraduate minor called Sustainability-in-Action consisting of four interlinked courses. When formally approved, the minor will be offered…

  2. World Perspective Case Descriptions on Educational Programs for Adults: Netherlands.

    ERIC Educational Resources Information Center

    Balde, Maatje; And Others

    Twenty adult education programs being conducted in the Netherlands are described in the case studies in this packet. The courses range from adult basic education to continuing education courses in languages, from basic nursing courses to advanced neurology. The following programs are profiled: (1) open school (Balde); (2) study house for adults…

  3. Schmallenberg virus in Culicoides spp. biting midges, the Netherlands, 2011.

    PubMed

    Elbers, Armin R W; Meiswinkel, Rudy; van Weezep, Erik; Sloet van Oldruitenborgh-Oosterbaan, Marianne M; Kooi, Engbert A

    2013-01-01

    To determine which species of Culicoides biting midges carry Schmallenberg virus (SBV), we assayed midges collected in the Netherlands during autumn 2011. SBV RNA was found in C. scoticus, C. obsoletus sensu stricto, and C. chiopterus. The high proportion of infected midges might explain the rapid spread of SBV throughout Europe.

  4. Child Health in the Netherlands: Facts and Figures, 1997.

    ERIC Educational Resources Information Center

    Hirasing, R. A.; van Zaal, M. A. E.; Meulmeester, J. F.; Verbrugge, H. P.

    This book presents information on the current health status of children and adolescents in the Netherlands. Chapter 1 discusses demographic factors, including population trends and life expectancy. Chapter 2 focuses on children's health status, reporting on child mortality rates, abortion, birth rate, family planning, perinatal health problems,…

  5. Restructuring Secondary Education in the Netherlands: Between Control and Autonomy.

    ERIC Educational Resources Information Center

    Veugelers, Wiel; Zijlstra, Henk

    This article analyzes the effects of senior secondary-education reform in The Netherlands and the effects that these changes have exerted on teachers. It focuses on the way that changes, such as profiles, new exam programs, and alterations in "study house," interacted with and influenced teachers' tasks. The paper provides an overview of…

  6. Curriculum Development of Computer and Information Literacy in the Netherlands.

    ERIC Educational Resources Information Center

    Hartsuijker, Ard P.

    1986-01-01

    Describes a national project on computer and information literacy in the Netherlands for all students in lower secondary education, i.e., the 12- to 16-year-old age group. Curriculum development is discussed with emphasis on equal participation by female students and teachers, and hardware and software specifications are noted. (LRW)

  7. The Big Five of School Leadership Competences in the Netherlands

    ERIC Educational Resources Information Center

    Kruger, Meta

    2009-01-01

    School leaders have been given an important role in initiating and implementing school improvement, which demands new forms of leadership. This invokes the question of the basic competences for leadership that are presently required. This article focuses on the formulation of competences for school leaders in the Netherlands with the aim of…

  8. Laboratories for Educational Innovation: Honors Programs in the Netherlands

    ERIC Educational Resources Information Center

    Wolfensberger, Marca V. C.; Van Eijl, Pierre; Pilot, Albert

    2012-01-01

    In Dutch universities, honors programs are a fast growing development. The first such programs started in 1993. Twenty years later a large number of programs are implemented at nearly all research universities and also at many universities of applied sciences in the Netherlands. Recent data have revealed significant diversity in the types and…

  9. Situation Reports--Bahamas, Brasil, Guatemala, Netherlands Antilles (Curacao), Uruguay.

    ERIC Educational Resources Information Center

    International Planned Parenthood Federation, London (England).

    Data relating to population and family planning in four foreign countries are presented in these situation reports. Countries included are Bahamas, Guatemala, Netherlands Antilles (Curacao), and Uruguay. Information is provided under two topics, general background and family planning situation, where appropriate and if it is available. General…

  10. Education, Allocation and Earnings in the Netherlands: Overschooling?

    ERIC Educational Resources Information Center

    Hartog, Joop; Oosterbeek, Hessel

    1988-01-01

    Large changes in educational composition of the Netherlands labor force in the past two decades have produced marked changes in the distribution of individuals by education level across job levels. Undereducation has been reduced, and overeducation has been increased. The latter situation does not imply inefficiency because even years of…

  11. Pica and the Academic Libraries in the Netherlands.

    ERIC Educational Resources Information Center

    Oosterop, Danielle

    1996-01-01

    Describes Pica, an organization in the Netherlands which evolved from the Project for Integrated Catalogue Automation that includes the National Library and all university libraries. Topics include the organizational structure, the shared online cataloging system, interlibrary loan, library networks and database access, and electronic document…

  12. Variegated Squirrel Bornavirus 1 in Squirrels, Germany and the Netherlands

    PubMed Central

    Schlottau, Kore; Jenckel, Maria; van den Brand, Judith; Fast, Christine; Herden, Christiane; Höper, Dirk; Homeier-Bachmann, Timo; Thielebein, Jens; Mensing, Niels; Diender, Bert; Hoffmann, Donata; Ulrich, Rainer G.; Mettenleiter, Thomas C.; Koopmans, Marion; Tappe, Dennis; Schmidt-Chanasit, Jonas; Reusken, Chantal B.E.M.; Hoffmann, Bernd

    2017-01-01

    We screened squirrels in Germany and the Netherlands for the novel zoonotic variegated squirrel bornavirus 1 (VSBV-1). The detection of VSBV-1 in 11 squirrels indicates a considerable risk for transmission to humans handling those animals. Therefore, squirrels in contact with humans should routinely be tested for VSBV-1. PMID:28221112

  13. Selection and Training of Secondary School Headteachers in the Netherlands.

    ERIC Educational Resources Information Center

    Esp, D. G.

    The Netherlands has an effective training system for secondary school administrators, in spite of an outwardly complex and compartmentalized education system. Nearly one-third of the schools are Roman Catholic, one-third Protestant, and one-third run by municipalities and by private boards. There is increasing emphasis on the growing complexity of…

  14. Stagnation in Mortality Decline among Elders in the Netherlands

    ERIC Educational Resources Information Center

    Janssen, Fanny; Nusselder, Wilma J.; Looman, Caspar W. N.; Mackenbach, Johan P.; Kunst, Anton E.

    2003-01-01

    Purpose: This study assesses whether the stagnation of old-age (80+) mortality decline observed in The Netherlands in the 1980s continued in the 1990s and determines which factors contributed to this stagnation. Emphasis is on the role of smoking. Design and Methods: Poisson regression analysis with linear splines was applied to total and…

  15. The Master in Addiction Medicine Program in the Netherlands

    ERIC Educational Resources Information Center

    De Jong, Cornelis; Luycks, Lonneke; Delicat, Jan-Wilm

    2011-01-01

    Since 2007 there is a full-time, 2-year professional training in addiction medicine in the Netherlands. The aim of this article is to describe in detail the development and present status of the Dutch Master in Addiction Medicine (MiAM) program. In this competency-based professional training, theoretical courses are integrated with learning in…

  16. Working Economics: Labor Policy and Conducive Economy in the Netherlands

    ERIC Educational Resources Information Center

    Korver, Ton

    2004-01-01

    The conducive economy challenges both the conceptual foundations and the practices of present-day economies. In the Netherlands, a few initiatives during the 1980s and early 1990s looked promising, in particular, as these initiatives focused on work quality as one major precondition for reducing disability and enhancing labor participation.…

  17. Teaching Gender and Geography: The Case of the Netherlands

    ERIC Educational Resources Information Center

    Fortuijn, Joos Droogleever

    2011-01-01

    Feminist geography teaching in universities in the Netherlands originated 30 years ago in an academic context that counteracted this new development for ideological reasons. Nowadays, the neoliberal conditions of the market have replaced the conservative ideology that prevailed 30 years ago. Feminist geography is supported as far as it returns…

  18. Community Care for People with Mental Retardation in the Netherlands.

    ERIC Educational Resources Information Center

    Dosen, Anton

    1988-01-01

    Services for people with mental retardation in the Netherlands are examined, with emphasis on normalization, placement options including group homes and institutionalization, guidance for families through the Social Pedological Service, and the care of mental illness in mentally retarded persons through special diagnostic and treatment centers.…

  19. Vocational Training in the Netherlands: Reform and Innovation.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    This volume presents a report on recent developments and current policy objectives in vocational education and training in the Netherlands. The study is based on a conceptual and analytical framework jointly elaborated by the Organisation for Economic Cooperation and Development Secretariat and representatives of member countries. Organized in two…

  20. Assessing Intelligence in Children and Youth Living in the Netherlands

    ERIC Educational Resources Information Center

    Hurks, Petra P. M.; Bakker, Helen

    2016-01-01

    In this article, we briefly describe the history of intelligence test use with children and youth in the Netherlands, explain which models of intelligence guide decisions about test use, and detail how intelligence tests are currently being used in Dutch school settings. Empirically supported and theoretical models studying the structure of human…

  1. Interagency Cooperation: Comparing U.S. and the Netherlands

    DTIC Science & Technology

    2010-01-14

    HGIS ). HGIS was created in 1997. This construction within the government’s budget is aimed to bring all foreign activities of all Ministries...activities, like HGIS in the Netherlands. This way Departments are forced to The administration should consider to make its case for Congress more

  2. The Netherlands in Fifty Maps: An Annotated Atlas.

    ERIC Educational Resources Information Center

    Tamsma, R.

    1988-01-01

    Statistical data relating to The Netherlands is presented in 50 maps that were originally published in the "Journal of Economic and Social Geography" between 1977 and 1986. Lengthy annotations accompanying each map provide important background information on the issues depicted. These elucidations were written with the foreign reader in…

  3. Historical Film Documentation at the Netherlands Information Service.

    ERIC Educational Resources Information Center

    Egeter van Kuyk, R. H. J.

    1981-01-01

    Describes the computerized film documentation system being developed for use in the Film Archives of the Netherlands Information Service. The organization of the films by historical periods, the film access system, content analysis of the films, and operation of the film retrieval system are discussed. Four figures accompany the text. (Author/JL)

  4. Social Partners and Vocational Education in the Netherlands.

    ERIC Educational Resources Information Center

    van Dijk, Cor; And Others

    This document on the links between the world of work and the world of vocational training in the Netherlands includes 5 chapters, a list of abbreviations, and a 42-item reference list. Chapter 1 introduces the report. Chapter 2 outlines the Dutch system of industrial relations and presents the concept of "neocorporatism." Chapter 3…

  5. OECD Review of Career Guidance Policies. Netherlands: Country Note.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    The Netherlands' career guidance system and policies were evaluated. Data were collected through meetings with policymakers and guidance practitioners in the public and private sectors, analysis of data from a national questionnaire, and a review of pertinent documentation. The evaluation focused on the following areas: markets and the role of…

  6. Sign Language of the Netherlands (SLN) and Deaf Culture.

    ERIC Educational Resources Information Center

    van den Bogaerde, Beppie; Stuifzand, Marjan

    2003-01-01

    Describes a new professional training program for teachers and interpreters in Sign Language of the Netherlands. Includes courses in Deaf culture linked to practical assignments that encourage students to go forth into the Deaf community and link the theoretical knowledge taught in the classes with their own experiences among the Deaf. (Contains…

  7. Sign Language Planning in the Netherlands between 1980 and 2010

    ERIC Educational Resources Information Center

    Schermer, Trude

    2012-01-01

    This article discusses several aspects of language planning with respect to Sign Language of the Netherlands, or Nederlandse Gebarentaal (NGT). For nearly thirty years members of the Deaf community, the Dutch Deaf Council (Dovenschap) have been working together with researchers, several organizations in deaf education, and the organization of…

  8. Child Guidance and Mental Health in the Netherlands

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2006-01-01

    In the Netherlands, as in the United States, the introduction of the concept of "mental health" in education is closely related to the development of a network of child guidance clinics. The first of these was established in Amsterdam in 1928. However, a substantial movement to actively promote mental health did not come into existence…

  9. Rethinking Postgraduate Education in Geography: The Case of the Netherlands

    ERIC Educational Resources Information Center

    Fortuijn, Joos Droogleever

    2012-01-01

    This paper discusses reforms in postgraduate education in geography in the Netherlands in the context of Europeanization and globalization. Europeanization and globalization have resulted in challenges as well as opportunities for students and universities. In terms of internationalization, Europeanization and the global economic crisis have…

  10. Pesticide Reduction Programs in Denmark, the Netherlands, and Sweden.

    ERIC Educational Resources Information Center

    Hurst, Peter

    1992-01-01

    The Netherlands, Denmark, and Sweden are leaders in introducing comprehensive and targeted risk reduction programs for pesticides. Describes these programs and their implementation, incorporating material obtained through interviews with representatives of the main constituencies involved in reduction Tables list pesticides that do not meet the…

  11. Schmallenberg Virus in Culicoides spp. Biting Midges, the Netherlands, 2011

    PubMed Central

    Meiswinkel, Rudy; van Weezep, Erik; Sloet van Oldruitenborgh-Oosterbaan, Marianne M.; Kooi, Engbert A.

    2013-01-01

    To determine which species of Culicoides biting midges carry Schmallenberg virus (SBV), we assayed midges collected in the Netherlands during autumn 2011. SBV RNA was found in C. scoticus, C. obsoletus sensu stricto, and C. chiopterus. The high proportion of infected midges might explain the rapid spread of SBV throughout Europe. PMID:23260040

  12. Summary of inaugural meeting of the Skin Care in Organ Recipients Group, UK, held at the Royal Society of Medicine, 7 October 2004.

    PubMed

    Eedy, D J

    2005-07-01

    This summarizes a meeting held in London at the Royal Society of Medicine, which was brought together by Prof. Fenella Wojnarowska, Professor of Dermatology at Churchill Hospital, Oxford and cofounder of Skin Care in Organ Recipients, UK (SCOR.UK).

  13. From Abydos to the Valley of the Kings and Amarna: the conception of royal funerary landscapes in the New Kingdom

    NASA Astrophysics Data System (ADS)

    Magli, G.

    Royal funerary landscapes in Egypt show a remarkable continuity in the use of symbols and in the interplay between natural and man-built features. In such a context directionality, both in the sense of succession of elements and of orientation of single buildings and tombs, plays a relevant role in governing the landscape in accordance with the idea of "cosmic" order, the basis of the temporal power of the Pharaoh. This paper investigates cognitive aspects of the funerary royal landscapes of the New Kingdom, with special emphasis on the connections with astronomy and orientation. A close similarity between the sacred landscape at western Thebes and the early dynastic funerary landscape at Abydos comes out and such a similarity may have been one of the reasons for the choice of Valley of the Kings as royal Necropolis. The original, actually unique way in which old symbols and features were re-elaborated by Akhenaten in planning his funerary landscape at Amarna is also highlighted.

  14. Copper mining pollution detected on Isle Royale in Lake Superior between 6500 and 5400 years ago using sediment geochemical studies

    NASA Astrophysics Data System (ADS)

    Pompeani, D. P.; Abbott, M. B.; Bain, D.; DePasqual, S.; Finkenbinder, M. S.

    2014-12-01

    Isle Royale, in Lake Superior, was the site of indigenous copper mining, however the timing and geographical context of past mining activity is poorly understood. We analyzed sorbed metal concentrations, carbon, nitrogen, and organic matter to document past mining pollution in sediment cores recovered from McCargoe Cove; a long, narrow inlet of Lake Superior on Isle Royale adjacent to a high concentration of ancient copper mines. Concentrations of lead, copper, and potassium increase in the sediments at McCargoe Cove after 1860 AD and between 6500 and 5400 years before 1950 AD or present (yr BP). Metal pollution increases coincide with radiocarbon dates associated with prehistoric copper artifacts and mines. These results, in combination with other lake sediment reconstruction sites located on Michigan's Keweenaw Peninsula, demonstrate that from 6500 to 5400 yr BP mining activities are detectable across the Lake Superior region. Interestingly a coherent cessation of lead emissions at multiple study sites after ~5400 yr BP coincides with the onset of dry conditions found in regional paleoclimate proxy records. After ~5000 yr BP, lead concentrations on both Isle Royale and the Keweenaw Peninsula remain at background levels until the onset of modern pollution increases ~1860 AD.

  15. Molecular and biochemical characterization of the major royal jelly protein in bumblebees suggest a non-nutritive function.

    PubMed

    Kupke, Jens; Spaethe, Johannes; Mueller, Martin J; Rössler, Wolfgang; Albert, Štefan

    2012-09-01

    Honeybee queens are generated on purpose by extensive feeding with a glandular secretion termed royal jelly. Major royal jelly proteins (MRJPs) are the dominant proteinaceous component of royal jelly. One of them, MRJP1, was found to play a central role in honeybee queen development. Genes encoding MRJPs were reported to originate from a single originator, and several of them have evolved nutritive function. Phylogenetic analysis provides evidence that the same originator has multiplied independently in Nasonia and ant lineages. Here we show that bumblebees represent a transition species preserving a single-copy pre-multiplication stage of MRJP evolution. By exploring the single-copy BtRJPL gene, we found striking similarities with MRJPs of the honeybee such as gene structure and expression regulation. At the same time it turned out that BtRJPL does not fulfill criteria for functioning as a nutritive protein. Instead we found evidence that BtRJPL is involved in food digestion or modification, which appears to be the original MRJP function, at least in this lineage. Thus, the evolutionary pattern of MRJPs in hymenopterans constitutes an excellent example of a functional diversification combined with the origin of new properties followed by intensive gene duplication events.

  16. Space Radar Image of Flevoland, Netherlands

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This is a three-frequency false color image of Flevoland, The Netherlands, centered at 52.4 degrees north latitude, 5.4 degrees east longitude. This image was acquired by the Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) aboard space shuttle Endeavour on April 14, 1994. It was produced by combining data from the X-band, C-band and L-band radars. The area shown is approximately 25 kilometers by 28 kilometers (15-1/2 by 17-1/2 miles). Flevoland, which fills the lower two-thirds of the image, is a very flat area that is made up of reclaimed land that is used for agriculture and forestry. At the top of the image, across the canal from Flevoland, is an older forest shown in red; the city of Harderwijk is shown in white on the shore of the canal. At this time of the year, the agricultural fields are bare soil, and they show up in this image in blue. The changes in the brightness of the blue areas are equal to the changes in roughness. The dark blue areas are water and the small dots in the canal are boats. This SIR-C/X-SAR supersite is being used for both calibration and agricultural studies. Several soil and crop ground-truth studies will be conducted during the shuttle flight. In addition, about 10calibration devices and 10 corner reflectors have been deployed to calibrate and monitor the radar signal. One of these transponders can be seen as a bright star in the lower right quadrant of the image. This false-color image was made using L-band total power in the red channel, C-band total power in the green channel, and X-band VV polarization in the blue channel. Spaceborne Imaging Radar-C and X-Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be

  17. Tetracycline residues in royal jelly and honey by liquid chromatography tandem mass spectrometry: validation study according to Commission Decision 2002/657/EC.

    PubMed

    Giannetti, L; Longo, F; Buiarelli, F; Russo, M V; Neri, B

    2010-09-01

    A specific, sensitive and robust liquid chromatography tandem mass spectrometry method for determining oxytetracycline, tetracycline, chlortetracycline and doxycycline in royal jelly and honey samples is presented. Extraction of drug residues was performed by ammonium acetate buffer as extractant followed by a clean-up with metal chelate affinity chromatography and solid-phase extraction. Tetracycline analysis was performed using liquid chromatography-electrospray ionisation-tandem mass spectrometry. The presented method is the first validated for royal jelly and in accordance with the requirements set by Commission Decision 2002/657/EC. Recoveries of the methods, calculated spiking the samples at 5.0, 10.0, 20.0 and 30.0 μg kg(-1), were 79% to 90% for honey and 77% to 90% for royal jelly. The intra-day precision (RSD) ranged between 8.1% and 15.0% for honey and from 9.1% to 16.3% for royal jelly, while inter-day precision values were from 10.2% to 17.6% and from 10.6% to 18.4% respectively for honey and royal jelly. Linearity for the four analytes was calculated from 5.0 to 50.0 μg kg(-1). The decision limits (CCα) ranged from 6.2 to 6.4 μg kg(-1) and from 6.1 to 6.5 μg kg(-1) for honey and royal jelly, respectively. Detection capabilities values (CCβ) ranged between 7.2 and 7.7 μg kg(-1) and from 7.3 to 7.9 μg kg(-1) respectively for honey and royal jelly. The developed method is currently in use for confirmation of the official control analysis of honey and royal jelly samples.

  18. Operational Water Resources Forecasting System for The Netherlands

    NASA Astrophysics Data System (ADS)

    Weerts, A.; Prinsen, G.; Patzke, S.; van Verseveld, W.; Berger, H.; Kroon, T.

    2011-12-01

    During periods of low flows of the Rhine and Meuse Rivers and/or agricultural drought the National Coordinating Committee for Water Distribution of the Netherlands has to decide how the available surface water is used and allocated between different functions like safety (e.g. peat-levee stability), reduction of salt water intrusion, drinking water and agriculture. Since 2009, a real time forecasting system is operational and provides daily nationwide forecasts on the total fresh surface water supply, groundwater levels and saturation of the root zone at 250x250 meters using a surface water model coupled with a MODFLOW-MetaSWAP model of the saturated-unsaturated zone and with a lead-time of 10-30 days. In 2011, new forecasts products like a spatial groundwater anomaly plots for the weekly drought bulletin were introduced. Besides this product, a no rain scenario with a leadtime of 30 days and schematic status displays were also introduced. These products turned out to provide usefull information to support decision making and inform the public during the low period and unusal dry start of 2011 in the Netherlands and Rhine and Meuse basin. The changing patterns in groundwater anomaly give good insight into the hydrological behaviour of the Netherlands. The no-rain scenario provided usefull information to decide on maintaining increased target levels of Lake IJssel and Lake Marker (e.g. the main fresh water supply basins in the Netherlands). Displays of water quality infomation (chloride concentrations) helped to gain insight on the extend of salt water intrusion in the South-Western part of the Netherlands. The schematic status displays provide the water managers a quick and easy to understand overview of the hydrological status cumulating all the underlying detailed information.

  19. Operational Water Resources Forecasting System for The Netherlands

    NASA Astrophysics Data System (ADS)

    Weerts, A. H.; Prinsen, G.; Patzke, S.; van Verseveld, W.; Berger, H.; Kroon, T.

    2012-04-01

    During periods of low flows of the Rhine and Meuse Rivers and/or agricultural drought the National Coordinating Committee for Water Distribution of the Netherlands has to decide how the available surface water is used and allocated between different functions like safety (e.g. peat-levee stability), reduction of salt water intrusion, drinking water and agriculture. Since 2009, a real time forecasting system is operational and provides daily nationwide forecasts on the total fresh surface water supply, groundwater levels and saturation of the root zone at 250x250 meters using a surface water model coupled with a MODFLOW-MetaSWAP model of the saturated-unsaturated zone and with a lead-time of 10-30 days. In 2011, new forecasts products like a spatial groundwater anomaly plots for the weekly drought bulletin were introduced. Besides this product, a no rain scenario with a leadtime of 30 days and schematic status displays were also introduced. These products turned out to provide usefull information to support decision making and inform the public during the low period and unusal dry start of 2011 in the Netherlands and Rhine and Meuse basin. The changing patterns in groundwater anomaly give good insight into the hydrological behaviour of the Netherlands. The no-rain scenario provided usefull information to decide on maintaining increased target levels of Lake IJssel and Lake Marker (e.g. the main fresh water supply basins in the Netherlands). Displays of water quality infomation (chloride concentrations) helped to gain insight on the extend of salt water intrusion in the South-Western part of the Netherlands. The schematic status displays provide the water managers a quick and easy to understand overview of the hydrological status cumulating all the underlying detailed information.

  20. Lessons from history: morbidity of cold injury in the Royal Marines during the Falklands Conflict of 1982

    PubMed Central

    2013-01-01

    Background Environmental conditions in the Falklands Conflict of 1982 favoured the genesis of cold injuries. Immediately, post-war, cold injury morbidity and its contributory factors were assessed, in the personnel of UK 3 Commando Brigade (3 Cdo Bde). Methods A questionnaire survey of the 3,006 members of 3 Cdo Bde who landed on the islands was conducted within 6–10 weeks of the end of hostilities. Questions included those relating to features of cold injury, body morphology, age, symptoms experienced, past medical history and other possible contributory causes. Additionally, the unit medical team conducted a cursory examination. Data were sent to the Royal Navy Institute of Naval Medicine (INM), where the degree of likely cold injury was broadly classified (‘asymptomatic’ ‘mild’, ‘moderate’ or ‘severe’). A sample (total 109) was then selected at random from each category and subsequently examined and tested at the INM (nerve conduction, photoplethysmography and thermography testing). Forty-seven non-cold exposed sailors acted as a control group. These contemporaneous records have now been identified and interrogated. Results Some 2,354 (78%) completed questionnaires were returned, revealing that 1,505 (64%) had experienced symptoms of non-freezing cold injury. The morbidity in the infantry units was significantly greater than that in the support troops (1,051 (76%) vs 454 (46%), p < 0.05). No evidence was found to support an influence of a number of factors, commonly believed to have an aetiological role in the production of cold injury. Whilst there was no significant relationship between past history and cold injury morbidity in the brigade as a whole, or within the infantry units alone, an association was identified in the collective infantry units (73%) and the support/headquarter units (59%) (p < 0.05). In comparison with uninjured sailors who acted as controls (n = 47), nerve conduction was impaired in 35% of those screened

  1. Towards risk-based drought management in the Netherlands: quantifying the welfare effects of water shortage

    NASA Astrophysics Data System (ADS)

    van der Vat, Marnix; Femke, Schasfoort; Rhee Gigi, Van; Manfred, Wienhoven; Nico, Polman; Joost, Delsman; den Hoek Paul, Van; Maat Judith, Ter; Marjolein, Mens

    2016-04-01

    sectors hydrological data was lacking to make a reliable estimate of drought return periods. By 2021, the Netherlands Government aims to agree on the water supply service levels, which should describe water availability and quality that can be delivered with a certain return period. The Netherlands' Ministry of Infrastructure and the Environment, representatives of the regional water boards and Rijkswaterstaat (operating the main water system) as well as several consultants and research institutes are important stakeholders for further development of the method, evaluation of cases and the development of a quantitative risk-informed decision-making tool.

  2. Water quality and hydrology in a coastal region of The Netherlands

    NASA Astrophysics Data System (ADS)

    Van Rees Vellinga, E.; Toussaint, C. G.; Wit, K. E.

    For horticultural and agricultural water use, as well as with regard to environmental needs, it is imperative to maintain a good quality of the surface waters in central-west Netherlands. However, many factors with a deteriorating influence exist. To determine the influence of the various factors, a multidisciplinary investigation was carried out and the results were laid down in an extensive report in 1976 by the Institute for Land and Water Management Research (I.C.W.). This paper gives the summary of this geological and hydrological survey, and the data of groundwater as well as surface water quality. Information about the chemical composition of the surface waters and the groundwater aquifers is given in maps and graphs, and the methods with which the geohydrological data have been analyzed and applied are discussed. The influence on surface water quality of the most important polluting sources was established, and a conspectus of their contribution is given. Of these sources some are natural ones, whose contribution is almost impossible to be lowered. Other sources are the result of human activities within the area, which could be and are combated. A special and external source is the inlet water coming from the river Rhine. Fresh water is supplied to the central-west Netherlands region to compensate evaporation from the crops and also to flush the canals and ditches in order to combat the influence of the natural internal sources (in particular saline seepage) and the remainder of the other internal ones. In this context the quality of the Rhine water, the only source of fresh inlet water, remains of grave concern.

  3. Sounding-derived parameters associated with large hail and tornadoes in the Netherlands

    NASA Astrophysics Data System (ADS)

    Groenemeijer, P. H.; van Delden, A.

    2007-02-01

    A study is presented focusing on the potential value of parameters derived from radiosonde data or data from numerical atmospheric models for the forecasting of severe weather associated with convective storms. Parameters have been derived from soundings in the proximity of large hail, tornadoes (including tornadoes over water: waterspouts) and thunderstorms in the Netherlands. 66,365 radiosonde soundings from six stations in and around the Netherlands between 1 Dec. 1975 to 31 Aug. 2003 were classified as being associated or not associated with these weather phenomena using observational data from voluntary observers, the Dutch National Meteorological Institute (KNMI) and lightning data from the U.K. Met. Office. It was found that instability as measured by the Lifted Index or CAPE and 0-6 km wind shear independently have considerable skill in distinguishing environments of large hail and of non-hail-producing thunderstorms. It was also found that CAPE released below 3 km above ground level is on average high near waterspouts and weak tornadoes that mostly occur with low shear in the lowest 1 km above the Earth's surface. On the other hand, low-level shear is strong in environments of stronger (F1 and F2) tornadoes and increases with increasing F-scale. This is consistent with the notion that stretching of pre-existing vertical vorticity is the most important mechanism for the formation of weak tornadoes while the tilting of vorticity is more important with stronger tornadoes. The presented results may assist forecasters to assess the likelihood of severe hail or tornadoes.

  4. Implementing wildlife disease surveillance in the Netherlands, a One Health approach.

    PubMed

    Maas, M; Gröne, A; Kuiken, T; Van Schaik, G; Roest, H I J; Van Der Giessen, J W B

    2016-12-01

    The surveillance of (emerging) wildlife diseases can provide important, objective evidence of the circulation of pathogens of interest for veterinary and/or public health. The involvement of multiple research institutions in wildlife disease surveillance can ensure the best use of existing knowledge and expertise, but can also complicate or add challenges to the integration of wildlife disease surveillance components into a national programme. Documenting the existing efforts in a country's surveillance of wildlife diseases, including the institutes in which it takes place, provides a basis for policy-makers and authorities to identify gaps and priorities in their current surveillance programmes. This paper describes the wildlife disease surveillance activities taking place in the Netherlands. The authors recommend that, in addition to funding these current activities, surveillance resources should be allocated with the flexibility to allow for additional targeted surveillance, to detect and adequately respond to newly introduced or emerging pathogens. Similar structured overviews of wildlife disease surveillance in other countries would be very useful to facilitate international collaboration.

  5. The lameness of King Philip II and Royal Tomb I at Vergina, Macedonia.

    PubMed

    Bartsiokas, Antonis; Arsuaga, Juan-Luis; Santos, Elena; Algaba, Milagros; Gómez-Olivencia, Asier

    2015-08-11

    King Philip II was the father of Alexander the Great. He suffered a notorious penetrating wound by a lance through his leg that was nearly fatal and left him lame in 339 B.C.E. (i.e., 3 y before his assassination in 336 B.C.E.). In 1977 and 1978 two male skeletons were excavated in the Royal Tombs II and I of Vergina, Greece, respectively. Tomb I also contained another adult (likely a female) and a newborn skeleton. The current view is that Philip II was buried in Tomb II. However, the male skeleton of Tomb II bears no lesions to his legs that would indicate lameness. We investigated the skeletal material of Tomb I with modern forensic techniques. The male individual in Tomb I displays a conspicuous case of knee ankylosis that is conclusive evidence of lameness. Right through the overgrowth of the knee, there is a hole. There are no obvious signs that are characteristic of infection and osteomyelitis. This evidence indicates that the injury was likely caused by a severe penetrating wound to the knee, which resulted in an active inflammatory process that stopped years before death. Standard anthropological age-estimation techniques based on dry bone, epiphyseal lines, and tooth analysis gave very wide age ranges for the male, centered around 45 y. The female would be around 18-y-old and the infant would be a newborn. It is concluded that King Philip II, his wife Cleopatra, and their newborn child are the occupants of Tomb I.

  6. Characterisation of microRNAs from apple (Malus domestica 'Royal Gala') vascular tissue and phloem sap

    PubMed Central

    2010-01-01

    Background Plant microRNAs (miRNAs) are a class of small, non-coding RNAs that play an important role in development and environmental responses. Hundreds of plant miRNAs have been identified to date, mainly from the model species for which there are available genome sequences. The current challenge is to characterise miRNAs from plant species with agricultural and horticultural importance, to aid our understanding of important regulatory mechanisms in crop species and enable improvement of crops and rootstocks. Results Based on the knowledge that many miRNAs occur in large gene families and are highly conserved among distantly related species, we analysed expression of twenty-one miRNA sequences in different tissues of apple (Malus x domestica 'Royal Gala'). We identified eighteen sequences that are expressed in at least one of the tissues tested. Some, but not all, miRNAs expressed in apple tissues including the phloem tissue were also detected in the phloem sap sample derived from the stylets of woolly apple aphids. Most of the miRNAs detected in apple phloem sap were also abundant in the phloem sap of herbaceous species. Potential targets for apple miRNAs were identified that encode putative proteins shown to be targets of corresponding miRNAs in a number of plant species. Expression patterns of potential targets were analysed and correlated with expression of corresponding miRNAs. Conclusions This study validated tissue-specific expression of apple miRNAs that target genes responsible for plant growth, development, and stress response. A subset of characterised miRNAs was also present in the apple phloem translocation stream. A comparative analysis of phloem miRNAs in herbaceous species and woody perennials will aid our understanding of non-cell autonomous roles of miRNAs in plants. PMID:20682080

  7. The lameness of King Philip II and Royal Tomb I at Vergina, Macedonia

    PubMed Central

    Bartsiokas, Antonis; Arsuaga, Juan-Luis; Santos, Elena; Algaba, Milagros; Gómez-Olivencia, Asier

    2015-01-01

    King Philip II was the father of Alexander the Great. He suffered a notorious penetrating wound by a lance through his leg that was nearly fatal and left him lame in 339 B.C.E. (i.e., 3 y before his assassination in 336 B.C.E.). In 1977 and 1978 two male skeletons were excavated in the Royal Tombs II and I of Vergina, Greece, respectively. Tomb I also contained another adult (likely a female) and a newborn skeleton. The current view is that Philip II was buried in Tomb II. However, the male skeleton of Tomb II bears no lesions to his legs that would indicate lameness. We investigated the skeletal material of Tomb I with modern forensic techniques. The male individual in Tomb I displays a conspicuous case of knee ankylosis that is conclusive evidence of lameness. Right through the overgrowth of the knee, there is a hole. There are no obvious signs that are characteristic of infection and osteomyelitis. This evidence indicates that the injury was likely caused by a severe penetrating wound to the knee, which resulted in an active inflammatory process that stopped years before death. Standard anthropological age-estimation techniques based on dry bone, epiphyseal lines, and tooth analysis gave very wide age ranges for the male, centered around 45 y. The female would be around 18-y-old and the infant would be a newborn. It is concluded that King Philip II, his wife Cleopatra, and their newborn child are the occupants of Tomb I. PMID:26195763

  8. Noise exposure and cognitive performance: A study on personnel on board Royal Norwegian Navy vessels.

    PubMed

    Irgens-Hansen, Kaja; Gundersen, Hilde; Sunde, Erlend; Baste, Valborg; Harris, Anette; Bråtveit, Magne; Moen, Bente E

    2015-01-01

    Prior research shows that work on board vessels of the Royal Norwegian Navy (RNoN) is associated with noise exposure levels above recommended standards. Further, noise exposure has been found to impair cognitive performance in environmental, occupational, and experimental settings, although prior research in naval and maritime settings is sparse. The aim of this study was to evaluate cognitive performance after exposure to noise among personnel working on board vessels in the RNoN. Altogether 87 Navy personnel (80 men, 7 women; 31 ± 9 years) from 24 RNoN vessels were included. Noise exposure was recorded by personal noise dosimeters at a minimum of 4 h prior to testing, and categorized into 4 groups for the analysis: <72.6 dB(A), 72.6-77.0 dB(A), 77.1-85.2 dB(A), and >85.2 dB(A). The participants performed a visual attention test based on the Posner cue-target paradigm. Multivariable general linear model (GLM) analyses were performed to analyze whether noise exposure was associated with response time (RT) when adjusting for the covariates age, alertness, workload, noise exposure in test location, sleep the night before testing, use of hearing protection device (HPD), and percentage of errors. When adjusting for covariates, RT was significantly increased among personnel exposed to >85.2 dB(A) and 77.1-85.2 dB(A) compared to personnel exposed to <72.6 dB(A).

  9. Visitors' perception of thermal comfort during extreme heat events at the Royal Botanic Garden Melbourne.

    PubMed

    Lam, Cho Kwong Charlie; Loughnan, Margaret; Tapper, Nigel

    2016-01-06

    Outdoor thermal comfort studies have mainly examined the perception of local residents, and there has been little work on how those conditions are perceived differently by tourists, especially tourists of diverse origins. This issue is important because it will improve the application of thermal indices in predicting the thermal perception of tourists. This study aims to compare the differences in thermal perception and preferences between local and overseas visitors to the Royal Botanic Garden (RBG) in Melbourne during summer. An 8-day survey was conducted in February 2014 at four sites in the garden (n = 2198), including 2 days with maximum temperature exceeding 40 °C. The survey results were compared with data from four weather stations adjacent to the survey locations. One survey location, 'Fern Gully', has a misting system and visitors perceived the Fern Gully to be cooler than other survey locations. As the apparent temperature exceeded 32.4 °C, visitors perceived the environment as being 'warm' or 'hot'. At 'hot' conditions, 36.8 % of European visitors voted for no change to the thermal conditions, which is considerably higher than the response from Australian visitors (12.2 %) and Chinese visitors (7.5 %). Study results suggest that overseas tourists have different comfort perception and preferences compared to local Australians in hot weather based at least in part on expectations. Understanding the differences in visitors' thermal perception is important to improve the garden design. It can also lead to better tour planning and marketing to potential visitors from different countries.

  10. The impact of The Royal College of Surgeons of England research fellowship scheme

    PubMed Central

    Shalhoub, J; Cromwell, D; Coomer, M; Alderson, D

    2016-01-01

    Introduction The research fellowship scheme for surgeons in training run by The Royal College of Surgeons of England (RCS) had its 20th anniversary in 2013. A survey was undertaken to assess outcomes of the scheme during those 20 years. Methods Fellowship recipients were invited to complete an online 20-item questionnaire about their fellowship research and research activities since its completion. The questionnaire covered type of research undertaken, higher research degree enrolment, publications resulting from the fellowship research and subsequent research career. Results Of the 502 RCS fellowship recipients, 361 responded (72%). Their research covered a broad array of topics, Almost two-thirds (62%) undertook laboratory-based research and most of the remainder conducted patient-based clinical research. The vast majority (96%) of respondents had enrolled for a higher degree, with a high completion rate: 91% of fellowship recipients in the first 15 years of the scheme obtained their degree. Of the fellowships from the first 15 years of the scheme, between a fifth and a third of recipients subsequently held an academic position. The median number of peer reviewed articles and presentations per recipient was 3 and 6 respectively. Almost two-thirds (60%) of respondents had obtained funding for further research, with over half of these receiving grants from national research funding bodies. Conclusions The RCS research fellowship scheme has helped trainee surgeons to undertake research towards the start of their career. Most trainees used RCS fellowships as part of their funding towards a higher degree and this was regularly achieved, along with a number of peer reviewed publications. A significant proportion of fellowship recipients progressed into academic positions in surgery. PMID:27138854

  11. Noise exposure and cognitive performance: A study on personnel on board Royal Norwegian Navy vessels

    PubMed Central

    Irgens-Hansen, Kaja; Gundersen, Hilde; Sunde, Erlend; Baste, Valborg; Harris, Anette; Bråtveit, Magne; Moen, Bente E.

    2015-01-01

    Prior research shows that work on board vessels of the Royal Norwegian Navy (RNoN) is associated with noise exposure levels above recommended standards. Further, noise exposure has been found to impair cognitive performance in environmental, occupational, and experimental settings, although prior research in naval and maritime settings is sparse. The aim of this study was to evaluate cognitive performance after exposure to noise among personnel working on board vessels in the RNoN. Altogether 87 Navy personnel (80 men, 7 women; 31 ± 9 years) from 24 RNoN vessels were included. Noise exposure was recorded by personal noise dosimeters at a minimum of 4 h prior to testing, and categorized into 4 groups for the analysis: <72.6 dB(A), 72.6-77.0 dB(A), 77.1-85.2 dB(A), and >85.2 dB(A). The participants performed a visual attention test based on the Posner cue-target paradigm. Multivariable general linear model (GLM) analyses were performed to analyze whether noise exposure was associated with response time (RT) when adjusting for the covariates age, alertness, workload, noise exposure in test location, sleep the night before testing, use of hearing protection device (HPD), and percentage of errors. When adjusting for covariates, RT was significantly increased among personnel exposed to >85.2 dB(A) and 77.1-85.2 dB(A) compared to personnel exposed to <72.6 dB(A). PMID:26356374

  12. Study on The Effect of Royal Jelly on Reproductive Parameters in Streptozotocin-Induced Diabetic Rats

    PubMed Central

    Ghanbari, Elham; Nejati, Vahid; Najafi, Gholamreza; Khazaei, Mozafar; Babaei, Mohammad

    2015-01-01

    Background Diabetes mellitus has a variety of structural and functional effects on the male reproductive system. Diabetes results in reduced sperm parameters and libido. The present study aims to investigate the effects of royal jelly (RJ) on reproductive parameters of testosterone and malondialdehyde (MDA) production in diabetic rats. Materials and Methods This experimental study was conducted on adult male Wistar rats. The animals were divided into four groups (n=8 per group): control, RJ, diabetic and diabetic treated with RJ. Diabetes was induced by intraperitoneal injection of 60 mg/kg body weight (BW) of streptozotocin (STZ). RJ, at a dose of 100 mg/kg BW was given by gavage. The duration of treatment was six weeks. After the treatment period the rats were sacrificed. The testes were weighed and changes in sperm count, motility, viability, deformity, DNA integrity and chromatin quality were analyzed. Serum testosterone and MDA concentrations of testicular tissue were determined. Data were analyzed by oneway ANOVA with p<0.05 as the significant level. Results STZ-induced diabetes decreased numerous reproductive parameters in rats. Testicular weight, sperm count, motility, viability and serum testosterone levels increased in the diabetic group treated with RJ. There was a significant decrease observed in sperm deformity, DNA integrity, chromatin quality, and tissue MDA levels in diabetic rats treated with RJ compared to the diabetic group (p<0.05). Conclusion RJ improved reproductive parameters such as testicular weight, sperm count, viability, motility, deformity, DNA integrity, chromatin quality, serum testosterone and testicular tissue MDA levels in diabetic rats. PMID:25918599

  13. The impact of The Royal College of Surgeons of England research fellowship scheme.

    PubMed

    Shalhoub, J; Cromwell, D; Coomer, M; Alderson, D

    2016-07-01

    Introduction The research fellowship scheme for surgeons in training run by The Royal College of Surgeons of England (RCS) had its 20th anniversary in 2013. A survey was undertaken to assess outcomes of the scheme during those 20 years. Methods Fellowship recipients were invited to complete an online 20-item questionnaire about their fellowship research and research activities since its completion. The questionnaire covered type of research undertaken, higher research degree enrolment, publications resulting from the fellowship research and subsequent research career. Results Of the 502 RCS fellowship recipients, 361 responded (72%). Their research covered a broad array of topics, Almost two-thirds (62%) undertook laboratory-based research and most of the remainder conducted patient-based clinical research. The vast majority (96%) of respondents had enrolled for a higher degree, with a high completion rate: 91% of fellowship recipients in the first 15 years of the scheme obtained their degree. Of the fellowships from the first 15 years of the scheme, between a fifth and a third of recipients subsequently held an academic position. The median number of peer reviewed articles and presentations per recipient was 3 and 6 respectively. Almost two-thirds (60%) of respondents had obtained funding for further research, with over half of these receiving grants from national research funding bodies. Conclusions The RCS research fellowship scheme has helped trainee surgeons to undertake research towards the start of their career. Most trainees used RCS fellowships as part of their funding towards a higher degree and this was regularly achieved, along with a number of peer reviewed publications. A significant proportion of fellowship recipients progressed into academic positions in surgery.

  14. Visitors' perception of thermal comfort during extreme heat events at the Royal Botanic Garden Melbourne

    NASA Astrophysics Data System (ADS)

    Lam, Cho Kwong Charlie; Loughnan, Margaret; Tapper, Nigel

    2016-01-01

    Outdoor thermal comfort studies have mainly examined the perception of local residents, and there has been little work on how those conditions are perceived differently by tourists, especially tourists of diverse origins. This issue is important because it will improve the application of thermal indices in predicting the thermal perception of tourists. This study aims to compare the differences in thermal perception and preferences between local and overseas visitors to the Royal Botanic Garden (RBG) in Melbourne during summer. An 8-day survey was conducted in February 2014 at four sites in the garden (n = 2198), including 2 days with maximum temperature exceeding 40 °C. The survey results were compared with data from four weather stations adjacent to the survey locations. One survey location, `Fern Gully', has a misting system and visitors perceived the Fern Gully to be cooler than other survey locations. As the apparent temperature exceeded 32.4 °C, visitors perceived the environment as being `warm' or `hot'. At `hot' conditions, 36.8 % of European visitors voted for no change to the thermal conditions, which is considerably higher than the response from Australian visitors (12.2 %) and Chinese visitors (7.5 %). Study results suggest that overseas tourists have different comfort perception and preferences compared to local Australians in hot weather based at least in part on expectations. Understanding the differences in visitors' thermal perception is important to improve the garden design. It can also lead to better tour planning and marketing to potential visitors from different countries.

  15. Faculty of Prehospital Care, Royal College of Surgeons Edinburgh guidance for medical provision for wilderness medicine.

    PubMed

    Mellor, Adrian; Dodds, Naomi; Joshi, Raj; Hall, John; Dhillon, Sundeep; Hollis, Sarah; Davis, Pete; Hillebrandt, David; Howard, Eva; Wilkes, Matthew; Langdana, Burjor; Lee, David; Hinson, Nigel; Williams, Thomas Harcourt; Rowles, Joe; Pynn, Harvey

    2015-01-01

    To support leaders and those involved in providing medical care on expeditions in wilderness environments, the Faculty of Pre-Hospital Care (FPHC) of The Royal College of Surgeons of Edinburgh convened an expert panel of leading healthcare professionals and expedition providers. The aims of this panel were to: (1) provide guidance to ensure the best possible medical care for patients within the geographical, logistical and human factor constraints of an expedition environment. (2) Give aspiring and established expedition medics a 'benchmark' of skills they should meet. (3) Facilitate expedition organisers in selecting the most appropriate medical cover and provider for their planned activity. A system of medical planning is suggested to enable expedition leaders to identify the potential medical risks and their mitigation. It was recognised that the scope of practice for wilderness medicine covers elements of primary healthcare, pre-hospital emergency medicine and preventative medicine. Some unique competencies were also identified. Further to this, the panel recommends the use of a matrix and advisory expedition medic competencies relating to the remoteness and medical threat of the expedition. This advice is aimed at all levels of expedition medic, leader and organiser who may be responsible for delivering or managing the delivery of remote medical care for participants. The expedition medic should be someone equipped with the appropriate medical competencies, scope of practice and capabilities in the expedition environment and need not necessarily be a qualified doctor. In addition to providing guidance regarding the clinical competencies required of the expedition medic, the document provides generic guidance and signposting to the more pertinent aspects of the role of expedition medic.

  16. Swimmer-Training Institutions

    ERIC Educational Resources Information Center

    O'Donnell, R. W.

    1972-01-01

    This satirical essay proposes an institution of higher learning that would prepare students to become swimmers" and swimming instructors. Curriculum, teaching methods, student selection and evaluation are modelled on certain contemporary teacher-training institutes. (PD)

  17. Canadian institute honours Hawking

    NASA Astrophysics Data System (ADS)

    Durrani, Matin

    2009-11-01

    The Perimeter Institute for Theoretical Physics in Waterloo, Canada, has announced that a major new extension to its campus will be known as the Stephen Hawking Centre. The extension, which is currently being built, is due to open in 2011 and will double the size of the institute. It will also provide a home for the institute's Masters students, the first of whom joined the Perimeter Institute this autumn as part of its Perimeter Scholars international programme.

  18. Dr David Maclagan (1785-1865): distinguished Military Surgeon, President of both the Royal College of Surgeons and Royal College Physicians of Edinburgh, founder of a medical and military dynasty.

    PubMed

    Kaufman, Matthew H

    2006-05-01

    Dr David Maclagan studied medicine in Edinburgh, obtaining the LRCS Edin Diploma in 1804 and graduating with the MD degree in 1805. Because he was too young to enter the army, he spent a year in London, principally at St. George's Hospital, and he gained the MRCS England Diploma in 1807. Then he entered the army as an Assistant Surgeon associated with the 91st Foot Regiment. He served at Walcheren in 1809 and in the Peninsula. Later he was seconded as a Surgeon-Major to the 9th Portuguese Brigade. After his promotion to Physician to the Forces, he superintended the hospital arrangements of the Portuguese Army. Between 1811 and 1814 he sent a series of letters, principally to his wife, giving his personal impressions of his life in the war zone. He also maintained two personal diaries that nominally detailed his activities in the Peninsula between 1812 and 1813. After the end of the fighting he was put on half-pay and returned to Edinburgh. Then he gained the Fellowship of the Royal College of Surgeons of Edinburgh in 1816 and was appointed a Surgeon to the New Town Dispensary. After he established himself in private practice in Edinburgh he became the Honorary Consulting Surgeon to the Dispensary until shortly before his death. He was elected President of the Edinburgh College of Surgeons in 1826-27. He became a Fellow of the Royal College of Physicians of Edinburgh in 1848, and was elected its President in 1856-57. He founded an important medical and military dynasty. Three of his sons joined the medical profession and four served in the army. One of his sons was appointed Archbishop of York. His eldest son followed in his father's footsteps and was also President of both Royal Colleges, of Surgeons and Physicians, in Edinburgh. His widow, Jane, and his seven sons survived him.

  19. Astronomical Institute of Athens

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The Astronomical Institute of Athens is the oldest research institute of modern Greece (it faces the Parthenon). The Astronomical Institute (AI) of the National Observatory of Athens (NOA) started its observational projects in 1847. The modern computer and research center are housed at the Penteli Astronomical Station with major projects and international collaborations focused on extragalactic ...

  20. Herzberg Institute of Astrophysics

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The Herzberg Institute of Astrophysics (HIA) is the Institute within the NATIONAL RESEARCH COUNCIL of Canada responsible for providing astronomical facilities, and developing related instrumentation and software for Canadian researchers. The Institute was established in 1975, and now operates 1.8 m and 1.2 m optical telescopes at the DOMINION ASTROPHYSICAL OBSERVATORY close to Victoria, BC, as we...

  1. Implementing Institutional Research Findings.

    ERIC Educational Resources Information Center

    Blai, Boris, Jr.

    Although many agree that institutional research in higher education has come of age and is accepted as a part of institutional management, great variations exist in the extent to which institutional research findings are synthesized and utilized in management decision-making. A number of reasons can be identified as accounting for this phenomenon,…

  2. Sources of Hepatitis E Virus Genotype 3 in the Netherlands

    PubMed Central

    Lodder, Willemijn J.; Lodder-Verschoor, Froukje; van den Berg, Harold H.J.L.; Vennema, Harry; Duizer, Erwin; Koopmans, Marion; de Roda Husman, Ana Maria

    2009-01-01

    Non–travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied. HEV genotype 3/open reading frame 2 sequences were detected in 53% of pig farms, 4% of wild boar feces, and 17% of surface water samples. HEV sequences grouped within 4 genotype 3 clusters, of which 1 is so far unique to the Netherlands. The 2 largest clusters contained 35% and 43% of the animal and environmental sequences and 75% and 6%, respectively, of human HEV sequences obtained from a study on Dutch hepatitis E patients. This finding suggests that infection risk may be also dependent on transmission routes other than the ones currently studied. Besides the route of exposure, virus characteristics may be an important determinant for HEV disease in humans. PMID:19239749

  3. Women in physics in the Netherlands: Progress and developments

    NASA Astrophysics Data System (ADS)

    Rudolf, Petra; de Graaf, Noortje; Koornstra, Renée-Andrée; van Tijn, Paula; Kool, Dorien

    2015-12-01

    The visibility of women and the awareness of a healthy gender balance in physics in the Netherlands have clearly improved over the last few years. Initiatives to promote women and their possibilities to pursue a career in physics are plentiful and commendable. Nevertheless, the numbers do not yet show the desired impact of all these initiatives. Although student numbers have increased, the percentage of female first-year student remains at approximately 13% of the total students in physics. Similarly, the relative numbers of female PhD candidates and postdocs have been stable over the last years at (both) approximately 20% to 25%. Despite the number of women obtaining a PhD in physics and continuing a scientific career as postdoc, the presence of women further up on the scientific ladder in physics remains strikingly low. We will here focus on the current status, ambitions, and initiatives in the Netherlands to promote women, and especially to keep them, in physics.

  4. Comparison between vaginal royal jelly and vaginal estrogen effects on quality of life and vaginal atrophy in postmenopausal women: a clinical trial study

    PubMed Central

    Seyyedi, Fatemeh; Kopaei, Mahmoud Rafiean; Miraj, Sepideh

    2016-01-01

    Objective This study was conducted to evaluate the therapeutic effects of vaginal royal jelly and vaginal estrogen on quality of life and vaginal atrophy in postmenopausal women. Methods This double-blind randomized controlled clinical trial was carried out at gynecology and obstetrics clinics of Hajar Hospital of Shahrekord University of Medical Sciences (Iran) from January 2013 to January 2014. The study was conducted on married postmenopausal women between 50 and 65 years old. Of 120 patients, 30 individuals were excluded based on the exclusion criteria, and 90 women were randomly distributed into three groups of 30 royal jelly vaginal cream 15%, vaginal Premarin, and placebo (lubricant), for three months. At the beginning and the end of the study, quality of life and vaginal cytology assay were evaluated. Data were analyzed by SPSS Version 11. Results Vaginal cream of royal jelly is significantly more effective than vaginal cream of Premarin and lubricant in improvement of quality of life in postmenopausal women (p<0.05). Moreover, Pap smear results showed that vaginal atrophy in vaginal Premarin group was lower than the other groups (p<0.001), and there was no significant difference between lubricant and royal jelly groups (p=0.89). Conclusion Administration of vaginal royal jelly was effective in quality-of-life improvement of postmenopausal women. Given to the various properties of royal jelly and its effectiveness on quality of life and vaginal atrophy in postmenopausal women, further studies are recommended for using =royal jelly in improving menopausal symptoms. Clinical trial registration The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the IRCT code: 2014112220043n1. Funding Shahrekord University of Medical Sciences supported this research (project no. 1440). PMID:28070251

  5. [Population forecasts for the Netherlands, 1985-2035].

    PubMed

    Cruijsen Hgjm

    1986-03-01

    Some results from the most recent official population forecasts for the Netherlands for the period up to 2035 are presented. These projections were prepared using a cohort-component model, and provide forecasts for individual years of age, sex, and marital status. The assumptions used in their preparation are described. Three variants are presented for the forecasts, of which the medium variant is considered the most probable. (summary in ENG)

  6. [Aliens in the Netherlands on January 1, 1991].

    PubMed

    Van Der Erf, R F; Tas, R F

    1991-09-01

    Data on foreigners living in the Netherlands as of January 1991 are analyzed. Consideration is given to age, marital status, fertility, mortality, migration, and population trends by nationality. It is noted that the 1990 increase of 50,000 resident aliens was the largest annual increase in this century. The greatest number of aliens come from Turkey, followed by those from elsewhere in Europe, and thirdly from Morocco. (SUMMARY IN ENG)

  7. Starting neonatal screening for haemoglobinopathies in The Netherlands.

    PubMed

    Giordano, P C

    2009-01-01

    Neonatal screening for haemoglobinopathies started in The Netherlands on 1 January 2007. The method of choice, high-performance liquid chromatography, and the universal setting have shown that the predicted incidence is indeed present in the country. Patients and carriers are reported in order to prevent morbidity, and for the primary prevention of serious haemoglobinopathies. Background, preceding discussion, health gain, implementation, provisional results and ethics issues are discussed, as well as matters concerning technology, know-how, and ongoing and future developments.

  8. The Genome of the Netherlands: design, and project goals.

    PubMed

    Boomsma, Dorret I; Wijmenga, Cisca; Slagboom, Eline P; Swertz, Morris A; Karssen, Lennart C; Abdellaoui, Abdel; Ye, Kai; Guryev, Victor; Vermaat, Martijn; van Dijk, Freerk; Francioli, Laurent C; Hottenga, Jouke Jan; Laros, Jeroen F J; Li, Qibin; Li, Yingrui; Cao, Hongzhi; Chen, Ruoyan; Du, Yuanping; Li, Ning; Cao, Sujie; van Setten, Jessica; Menelaou, Androniki; Pulit, Sara L; Hehir-Kwa, Jayne Y; Beekman, Marian; Elbers, Clara C; Byelas, Heorhiy; de Craen, Anton J M; Deelen, Patrick; Dijkstra, Martijn; den Dunnen, Johan T; de Knijff, Peter; Houwing-Duistermaat, Jeanine; Koval, Vyacheslav; Estrada, Karol; Hofman, Albert; Kanterakis, Alexandros; Enckevort, David van; Mai, Hailiang; Kattenberg, Mathijs; van Leeuwen, Elisabeth M; Neerincx, Pieter B T; Oostra, Ben; Rivadeneira, Fernanodo; Suchiman, Eka H D; Uitterlinden, Andre G; Willemsen, Gonneke; Wolffenbuttel, Bruce H; Wang, Jun; de Bakker, Paul I W; van Ommen, Gert-Jan; van Duijn, Cornelia M

    2014-02-01

    Within the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as a national node of the European BBMRI. One of the aims of BBMRI-NL is to enrich biobanks with different types of molecular and phenotype data. Here, we describe the Genome of the Netherlands (GoNL), one of the projects within BBMRI-NL. GoNL is a whole-genome-sequencing project in a representative sample consisting of 250 trio-families from all provinces in the Netherlands, which aims to characterize DNA sequence variation in the Dutch population. The parent-offspring trios include adult individuals ranging in age from 19 to 87 years (mean=53 years; SD=16 years) from birth cohorts 1910-1994. Sequencing was done on blood-derived DNA from uncultured cells and accomplished coverage was 14-15x. The family-based design represents a unique resource to assess the frequency of regional variants, accurately reconstruct haplotypes by family-based phasing, characterize short indels and complex structural variants, and establish the rate of de novo mutational events. GoNL will also serve as a reference panel for imputation in the available genome-wide association studies in Dutch and other cohorts to refine association signals and uncover population-specific variants. GoNL will create a catalog of human genetic variation in this sample that is uniquely characterized with respect to micro-geographic location and a wide range of phenotypes. The resource will be made available to the research and medical community to guide the interpretation of sequencing projects. The present paper summarizes the global characteristics of the project.

  9. Routine outcome measurement in the Netherlands - A focus on benchmarking.

    PubMed

    Delespaul, Philippe A E G

    2015-01-01

    Routine outcome measurement (ROM) is a 'hot' topic in the Netherlands. Over recent years the Netherlands have developed a centralized monitoring system for all reimbursed mental health interventions, in an attempt to improve the quality of care. The Foundation for Benchmarking Mental Health (SBG) is an independent knowledge centre for mental health providers and insurance companies. It was founded to organize and manage the countrywide ROM initiative. A Dutch countrywide ROM initiative is appealing, and the procedures in the Netherlands are described. However, the national ROM system was oversold. Arguments are discussed. It would have been a far better strategy if insurance companies and authorities had not focused on a national system but stimulated local data collection and requested a managerial plan-do-check-act (PDCA) cycle to stimulate service improvements from year to year. Within the same service, chances are higher that the same kind of clientele is served from year to year and therefore it will be easier to interpret the data. The ROM should regain its clinical focus. Mobile ROM systems using smartphones that collect sampled experiences could be an interesting future solution.

  10. Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools.

    PubMed

    Mandacaru, Samuel C; do Vale, Luis H F; Vahidi, Siavash; Xiao, Yiming; Skinner, Owen S; Ricart, Carlos A O; Kelleher, Neil L; de Sousa, Marcelo Valle; Konermann, Lars

    2017-03-21

    Royal jelly (RJ) triggers the development of female honeybee larvae into queens. This effect has been attributed to the presence of major royal jelly protein 1 (MRJP1) in RJ. MRJP1 isolated from royal jelly is tightly associated with apisimin, a 54-residue α-helical peptide that promotes the noncovalent assembly of MRJP1 into multimers. No high-resolution structural data are available for these complexes, and their binding stoichiometry remains uncertain. We examined MRJP1/apisimin using a range of biophysical techniques. We also investigated the behavior of deglycosylated samples, as well as samples with reduced apisimin content. Our mass spectrometry (MS) data demonstrate that the native complexes predominantly exist in a (MRJP14 apisimin4) stoichiometry. Hydrogen/deuterium exchange MS reveals that MRJP1 within these complexes is extensively disordered in the range of residues 20-265. Marginally stable secondary structure (likely antiparallel β-sheet) exists around residues 266-432. These weakly structured regions interchange with conformers that are extensively unfolded, giving rise to bimodal (EX1) isotope distributions. We propose that the native complexes have a "dimer of dimers" quaternary structure in which MRJP1 chains are bridged by apisimin. Specifically, our data suggest that apisimin acts as a linker that forms hydrophobic contacts involving the MRJP1 segment (316)VLFFGLV(322). Deglycosylation produces large soluble aggregates, highlighting the role of glycans as aggregation inhibitors. Samples with reduced apisimin content form dimeric complexes with a (MRJP12 apisimin1) stoichiometry. The information uncovered in this work will help pave the way toward a better understanding of the unique physiological role played by MRJP1 during queen differentiation.

  11. Heroin-assisted treatment in the Netherlands: History, findings, and international context.

    PubMed

    Blanken, Peter; van den Brink, Wim; Hendriks, Vincent M; Huijsman, Ineke A; Klous, Marjolein G; Rook, Elisabeth J; Wakelin, Jennifer S; Barendrecht, Cas; Beijnen, Jos H; van Ree, Jan M

    2010-04-01

    This monograph describes the history, findings and international context of heroin-assisted treatment (HAT) in the Netherlands. The monograph consists of (1) a short introduction and seven paragraphs describing the following aspects of HAT in the Netherlands: (2) history of HAT studies and implementation of routine HAT in the Netherlands; (3) main findings on efficacy, safety and cost-effectiveness from the two randomized controlled HAT trials in the Netherlands; (4) new findings from a large cohort study on the effectiveness of HAT in routine clinical practice in the Netherlands; (5) unique data on the patient's perspective of HAT; (6) data on the pharmacological and pharmaceutical basis for HAT in the Netherlands; (7) description of the registration process; and (8) account of the international context of HAT. Together, these data show that HAT can now be considered a safe and proven-effective intervention for the treatment of chronic, treatment-resistant heroin dependent patients.

  12. In-depth phosphoproteomic analysis of royal jelly derived from western and eastern honeybee species.

    PubMed

    Han, Bin; Fang, Yu; Feng, Mao; Lu, Xiaoshan; Huo, Xinmei; Meng, Lifeng; Wu, Bin; Li, Jianke

    2014-12-05

    The proteins in royal jelly (RJ) play a pivotal role in the nutrition, immune defense, and cast determination of honeybee larvae and have a wide range of pharmacological and health-promoting functions for humans as well. Although the importance of post-translational modifications (PTMs) in protein function is known, investigation of protein phosphorylation of RJ proteins is still very limited. To this end, two complementary phosphopeptide enrichment materials (Ti(4+)-IMAC and TiO2) and high-sensitivity mass spectrometry were applied to establish a detailed phosphoproteome map and to qualitatively and quantitatively compare the phosphoproteomes of RJ produced by Apis mellifera ligustica (Aml) and Apis cerana cerana (Acc). In total, 16 phosphoproteins carrying 67 phosphorylation sites were identified in RJ derived from western bees, and nine proteins phosphorylated on 71 sites were found in RJ produced by eastern honeybees. Of which, eight phosphorylated proteins were common to both RJ samples, and the same motif ([S-x-E]) was extracted, suggesting that the function of major RJ proteins as nutrients and immune agents is evolutionary preserved in both of these honeybee species. All eight overlapping phosphoproteins showed significantly higher abundance in Acc-RJ than in Aml-RJ, and the phosphorylation of Jelleine-II (an antimicrobial peptide, TPFKLSLHL) at S(6) in Acc-RJ had stronger antimicrobial properties than that at T(1) in Aml-RJ even though the overall antimicrobial activity of Jelleine-II was found to decrease after phosphorylation. The differences in phosphosites, peptide abundance, and antimicrobial activity of the phosphorylated RJ proteins indicate that the two major honeybee species employ distinct phosphorylation strategies that align with their different biological characteristics shaped by evolution. The phosphorylation of RJ proteins are potentially driven by the activity of extracellular serine/threonine protein kinase FAM20C-like protein (FAM20C

  13. Royal College of General Practitioners Research and Surveillance Centre (RCGP RSC) sentinel network: a cohort profile

    PubMed Central

    Correa, Ana; Hinton, William; McGovern, Andrew; van Vlymen, Jeremy; Yonova, Ivelina; Jones, Simon; de Lusignan, Simon

    2016-01-01

    Purpose The Royal College of General Practitioners Research and Surveillance Centre (RCGP RSC) is one of the longest established primary care sentinel networks. In 2015, it established a new data and analysis hub at the University of Surrey. This paper evaluates the representativeness of the RCGP RSC network against the English population. Participants and method The cohort includes 1 042 063 patients registered in 107 participating general practitioner (GP) practices. We compared the RCGP RSC data with English national data in the following areas: demographics; geographical distribution; chronic disease prevalence, management and completeness of data recording; and prescribing and vaccine uptake. We also assessed practices within the network participating in a national swabbing programme. Findings to date We found a small over-representation of people in the 25–44 age band, under-representation of white ethnicity, and of less deprived people. Geographical focus is in London, with less practices in the southwest and east of England. We found differences in the prevalence of diabetes (national: 6.4%, RCPG RSC: 5.8%), learning disabilities (national: 0.44%, RCPG RSC: 0.40%), obesity (national: 9.2%, RCPG RSC: 8.0%), pulmonary disease (national: 1.8%, RCPG RSC: 1.6%), and cardiovascular diseases (national: 1.1%, RCPG RSC: 1.2%). Data completeness in risk factors for diabetic population is high (77–99%). We found differences in prescribing rates and costs for infections (national: 5.58%, RCPG RSC: 7.12%), and for nutrition and blood conditions (national: 6.26%, RCPG RSC: 4.50%). Differences in vaccine uptake were seen in patients aged 2 years (national: 38.5%, RCPG RSC: 32.8%). Owing to large numbers, most differences were significant (p<0.00015). Future plans The RCGP RSC is a representative network, having only small differences with the national population, which have now been quantified and can be assessed for clinical relevance for specific studies. This

  14. The quandary of local people—Park relations in Nepal's Royal Chitwan National Park

    NASA Astrophysics Data System (ADS)

    Nepal, Sanjay K.; Weber, Karl E.

    1995-11-01

    This paper analyzes five major causes of park-people conflicts that have occurred in Nepal's Royal Chitwan National Park. The causes include illegal transactions of forest products from the park, livestock grazing in the park, illegal hunting and fishing, crop damage, and threats to human and animal life caused by wild animals from the park. The conflicts indicate a reciprocal relationship between the park and local people. They reflect the attitudes of local people and representatives of the park authority whose priorities and objectives largely diverge. The results show that people settled adjacent to the park are heavily dependent on its resources. Even in places where some, albeit few alternative sources exist, local people continue to trespass the park boundary as these sources are inadequate to ensure the fulfillment of local people's resource needs. Illegal transactions of resources continue throughout the year; however, they are less intense during summer due to flooding caused by the Rapti River, which forms the park boundary towards the northern section where this study is conducted. The frequency of local people's visits to the park is mainly determined by their age, distance between homesteads and park, and volume of crop loss caused by wild animals. Crop damage is the function of size of landholding, distance, and frequency of crop raid. Local people claim that they have no intention of letting their livestock graze in the park; however, the dense vegetation of the park attracts livestock grazing on riverbanks just outside the open park boundary. Many head of livestock are killed by carnivores of the park. Human casualties are mainly caused by sloth bear ( Melursus ursinus), tiger ( Panthera tigris), wild pig ( Sug scrofa), and rhinoceros ( Rhinoceros unicornis). There had been some earlier attempts to reconcile the conflicts by offering local people different kinds of compensations; however, these were unsuccessful measures. An integrated approach is

  15. Microbial monitoring in treated stone at the Royal Chapel of Granada

    NASA Astrophysics Data System (ADS)

    Jroundi, Fadwa; Pinar, Guadalupe; González-Muñoz, Maria Theresa; Sterflinger, Katja

    2014-05-01

    Biomineralization processes have been applied in situ to protect and consolidate decayed ornamental stone of the Royal Chapel in Granada (Spain). In few years, this conservation treatment has gained worth attention as environmentally friendly methodology for protection and consolidation of limestone because of the compatibilities shown between the new calcium carbonate cement and the original stone substrate. Moreover, the success of this approach may be related to the diversity of the microbiota inhabiting the stone and activated upon the biotreatment application and throughout the time. González-Muñoz et al. (2008) proposed a nutritional solution that activate among the bacteria inhabiting the stone those with carbonatogenic activity. In this study, a long-term (one, two and three years) monitoring of the microbiota present on the treated and untreated stones was done using a molecular strategy, including total DNA extraction, PCR amplification of 16S rRNA sequences, construction of clone libraries and fingerprinting by DGGE (Denaturing Gradient Gel Electrophoresis) analysis. Sequencing of the 16S rDNA revealed the dominant occurrence of members of Actinobacteria (44.20%), Gamma-proteobacteria (30.24%) and Chloroflexi (25.56%) after one year of the biotreatment. Whereas after two years, members of Cyanobacteria (22.10%) appeared and three years after, the microbiota consisted of only Actinobacteria and Cyanobacteria with approximately the same percentage in comparison with the untreated stones, dominated exclusively by Actinobacteria (100%). Fungal diversity followed the same dynamic as bacterial diversity being Ascomicota the predominant order before treatment. After one year, members of Basidiomycota and Viridiplantae appeared on the stone while two years after, the Viridiplantae dominated with a percentage of 84.77%. Finally, three years after the treatment, fungi population started to stabilize again and Ascomicota predominated next to 16.67% of

  16. Effect of Processed Honey and Royal Jelly on Cancer-Related Fatigue: A Double-Blind Randomized Clinical Trial

    PubMed Central

    Mofid, Bahram; Rezaeizadeh, Hossein; Termos, Abdulkarim; Rakhsha, Afshin; Mafi, Ahmad Rezazadeh; Taheripanah, Taiebeh; Ardakani, Mehran Mirabzadeh; Taghavi, Seyed Mohammad Esmaeil; Moravveji, Seyyed Alireza; Kashi, Amir Shahram Yousefi

    2016-01-01

    Background Cancer-related fatigue (CRF) is experienced by 50% to 90% of cancer patients and can severely affect their quality of life and functional capacity. Several randomized trials have recommended various ways to alleviate the symptoms of CRF with or without recourse to medications. Objective The aim of this study is to evaluate the effectiveness of processed honey and royal jelly on the symptoms of CRF in cancer patients who are undergoing hormone therapy, chemotherapy, chemo-radiation, or radiotherapy. Methods Fifty-two participants from the patients who visited the oncology clinic of Shohada-e-Tajrish hospital in Tehran (Iran) between May 2013 and August 2014 were selected and divided into two groups. The study group (26 patients) received processed honey and royal jelly, while the control group received pure honey. Both groups were instructed to consume their 5mL supplement twice daily for 4 weeks. Both groups were assessed at the beginning of the study, after 2 weeks, and then at the end of 4 weeks of treatment. Fatigue was measured using a visual analogue fatigue scale (VAFS) and fatigue severity scale (FSS). The results were compared between the two arms of study, and equality of probability distributions was assessed using a Kolmogorov–Smirnov test. Results The mean age of the 52 patients was 54.84. After two and four weeks of treatment with processed honey and royal jelly, VAFS and FSS due to treatment was better in the study group than in the control group, and the differences were statistically significant (p<0.001, p<0.001, respectively). Conclusion To the best of our knowledge, our study provided support for the use of processed honey and royal jelly to ameliorate CRF. The positive results of this study warrant further studies in this field. Clinical Trial Registration The study was registered in the Iranian Clinical Trial Registry Center (http://www.irct.ir) with the registration code: IRCT2015081423426N1. Funding The authors received no

  17. Hydraulics for Royal Gardens: Water Art as a Challenge for 18th Century Science and 21st Century Physics Teaching

    NASA Astrophysics Data System (ADS)

    Eckert, Michael

    2007-06-01

    Hydraulics is an engineering specialty and largely neglected as a topic in physics teaching. But the history of hydraulics from the Renaissance to the Baroque, merits our attention because hydraulics was then more broadly conceived as a practical and theoretical science; it served as a constant bone of contention for mechanics and mathematics; its obvious practical importance from raising water in mines to the playful fountains in royal gardens illustrates the social role of science like few others do. The playful character of historic hydraulics problems makes it also an appealing topic for modern science education.

  18. A pioneer from the Islamic Golden Age: Haly Abbas and spinal traumas in his principal work, The Royal Book.

    PubMed

    Belen, Deniz; Aciduman, Ahmet

    2006-10-01

    Spinal diseases have attracted medical scientists throughout the history of medicine, probably because they are relatively easy to diagnose and fairly simple to treat. Physicians who made great progress in medicine during the glorious Islamic civilizations also enthusiastically dealt with spine-related problems. More than a thousand years ago Persia was a cradle of medical learning, and Islamic medicine and other sciences spread westward from that center. A leading figure during this period was Haly Abbas, who created an excellent and compact medical encyclopedia, The Royal Book. Sadly, this book has rarely been cited in the literature. The subject of the present vignette is Abbas' work regarding spinal trauma.

  19. The effect of same-sex marriage laws on different-sex marriage: evidence from the Netherlands.

    PubMed

    Trandafir, Mircea

    2014-02-01

    It has long been argued that the legalization of same-sex marriage would have a negative impact on marriage. In this article, I examine how different-sex marriage in the Netherlands was affected by the enactment of two laws: a 1998 law that provided all couples with an institution almost identical to marriage (a "registered partnership") and a 2001 law that legalized same-sex marriage for the first time in the world. I first construct a synthetic control for the Netherlands using OECD data for the period 1988-2005 and find that neither law had significant effects on either the overall or different-sex marriage rate. I next construct a unique individual-level data set covering the period 1995-2005 by combining the Dutch Labor Force Survey and official municipal records. The estimates from a discrete-time hazard model with unobserved heterogeneity for the first-marriage decision confirm the findings in the aggregate analysis. The effects of the two laws are heterogeneous, with presumably more-liberal individuals (as defined by their residence or ethnicity) marrying less after passage of both laws and potentially more-conservative individuals marrying more after passage of each law.

  20. Implementing Quality Assurance at Royal University of Phnom Penh, Cambodia: Perceptions, Practices and Challenges

    ERIC Educational Resources Information Center

    Ros, Soveacha

    2010-01-01

    Quality Assurance in higher education has been an ongoing international issue for discussion. As higher education institutions move toward an era of accountability and accreditation, groups of stakeholders require proof of high-quality academic programs and services from higher education providers. Since the mid-1990s, most providers have strived…

  1. Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.

    PubMed

    Wang, Xiaoxia; Cao, Min; Dong, Yuqing

    2016-08-23

    Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders.

  2. Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.

    PubMed

    Makino, Junya; Ogasawara, Rie; Kamiya, Tetsuro; Hara, Hirokazu; Mitsugi, Yukari; Yamaguchi, Eiji; Itoh, Akichika; Adachi, Tetsuo

    2016-04-22

    Extracellular superoxide dismutase (EC-SOD) is one of the main SOD isozymes and plays an important role in the prevention of cardiovascular diseases by accelerating the dismutation reaction of superoxide. Royal jelly includes 10-hydroxy-2-decenoic acid (10H2DA, 2), which regulates the expression of various types of genes in epigenetics through the effects of histone deacetylase (HDAC) antagonism. The expression of EC-SOD was previously reported to be regulated epigenetically through histone acetylation in THP-1 cells. Therefore, we herein evaluated the effects of the royal jelly constituents 10-hydroxydecanoic acid (10HDA, 1), sebacic acid (SA, 3), and 4-hydroperoxy-2-decenoic acid ethyl ester (4-HPO-DAEE, 4), which is a derivative of 2, on the expression of EC-SOD in THP-1 cells. The treatment with 1 mM 1, 2, or 3 or 100 μM 4 increased EC-SOD expression and histone H3 and H4 acetylation levels. Moreover, the enrichment of acetylated histone H4 was observed in the proximal promoter region of EC-SOD and was caused by the partial promotion of ERK phosphorylation (only 4) and inhibition of HDAC activities, but not by the expression of HDACs. Overall, 4 exerted stronger effects than 1, 2, or 3 and has potential as a candidate or lead compound against atherosclerosis.

  3. Whole-genome resequencing of honeybee drones to detect genomic selection in a population managed for royal jelly

    PubMed Central

    Wragg, David; Marti-Marimon, Maria; Basso, Benjamin; Bidanel, Jean-Pierre; Labarthe, Emmanuelle; Bouchez, Olivier; Le Conte, Yves; Vignal, Alain

    2016-01-01

    Four main evolutionary lineages of A. mellifera have been described including eastern Europe (C) and western and northern Europe (M). Many apiculturists prefer bees from the C lineage due to their docility and high productivity. In France, the routine importation of bees from the C lineage has resulted in the widespread admixture of bees from the M lineage. The haplodiploid nature of the honeybee Apis mellifera, and its small genome size, permits affordable and extensive genomics studies. As a pilot study of a larger project to characterise French honeybee populations, we sequenced 60 drones sampled from two commercial populations managed for the production of honey and royal jelly. Results indicate a C lineage origin, whilst mitochondrial analysis suggests two drones originated from the O lineage. Analysis of heterozygous SNPs identified potential copy number variants near to genes encoding odorant binding proteins and several cytochrome P450 genes. Signatures of selection were detected using the hapFLK haplotype-based method, revealing several regions under putative selection for royal jelly production. The framework developed during this study will be applied to a broader sampling regime, allowing the genetic diversity of French honeybees to be characterised in detail. PMID:27255426

  4. Whole-genome resequencing of honeybee drones to detect genomic selection in a population managed for royal jelly.

    PubMed

    Wragg, David; Marti-Marimon, Maria; Basso, Benjamin; Bidanel, Jean-Pierre; Labarthe, Emmanuelle; Bouchez, Olivier; Le Conte, Yves; Vignal, Alain

    2016-06-03

    Four main evolutionary lineages of A. mellifera have been described including eastern Europe (C) and western and northern Europe (M). Many apiculturists prefer bees from the C lineage due to their docility and high productivity. In France, the routine importation of bees from the C lineage has resulted in the widespread admixture of bees from the M lineage. The haplodiploid nature of the honeybee Apis mellifera, and its small genome size, permits affordable and extensive genomics studies. As a pilot study of a larger project to characterise French honeybee populations, we sequenced 60 drones sampled from two commercial populations managed for the production of honey and royal jelly. Results indicate a C lineage origin, whilst mitochondrial analysis suggests two drones originated from the O lineage. Analysis of heterozygous SNPs identified potential copy number variants near to genes encoding odorant binding proteins and several cytochrome P450 genes. Signatures of selection were detected using the hapFLK haplotype-based method, revealing several regions under putative selection for royal jelly production. The framework developed during this study will be applied to a broader sampling regime, allowing the genetic diversity of French honeybees to be characterised in detail.

  5. Using 'reverse triage' to create hospital surge capacity: Royal Darwin Hospital's response to the Ashmore Reef disaster.

    PubMed

    Satterthwaite, Peter S; Atkinson, Carol J

    2012-02-01

    This report analyses the impact of reverse triage, as described by Kelen, to rapidly assess the need for continuing inpatient care and to expedite patient discharge to create surge capacity for disaster victims. The Royal Darwin Hospital was asked to take up to 30 casualties suffering from blast injuries from a boat carrying asylum seekers that had exploded 840 km west of Darwin. The hospital was full, with a backlog of cases awaiting admission in the emergency department. The Disaster Response Team convened at 10:00 to develop the surge capacity to admit up to 30 casualties. By 14:00, 56 beds (16% of capacity) were predicted to be available by 18:00. The special circumstances of a disaster enabled staff to suspend their usual activities and place a priority on triaging inpatients' suitability for discharge. The External Disaster Plan was activated and response protocols were followed. Normal elective activity was suspended. Multidisciplinary teams immediately assessed patients and completed the necessary clinical and administrative requirements to discharge them quickly. As per the Plan there was increased use of community care options: respite nursing home beds and community nursing services. Through a combination of cancellation of all planned admissions, discharging 19 patients at least 1 day earlier than planned and discharging all patients earlier in the day surge capacity was made available in Royal Darwin Hospital to accommodate blast victims. Notably, reverse triage resulted in no increase in clinical risk with only one patient who was discharged early returning for further treatment.

  6. Fast determination of adenosine 5'-triphosphate (ATP) and its catabolites in royal jelly using ultraperformance liquid chromatography.

    PubMed

    Zhou, Ling; Xue, XiaoFeng; Zhou, JinHui; Li, Yi; Zhao, Jing; Wu, LiMing

    2012-09-12

    To obtain insight into the metabolic regulation of adenosine 5'-triphosphate (ATP) in royal jelly and to determine whether ATP and its catabolites can be used as objective parameters to evaluate the freshness and quality of royal jelly (RJ), a rapid ultraperformance liquid chromatography (UPLC) method has been developed for feasible separation and quantitation of ATP and its catabolites in RJ, namely, adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate (AMP), inosine monophosphate (IMP), inosine (HxR), and hypoxanthine (Hx). The analytes in the sample were extracted using 5% precooled perchloric acid. Chromatographic separation was performed on a Waters Acquity UPLC system with a Waters BEH Shield RP18 column and gradient elution based on a mixture of two solvents: solvent A, 50 mM phosphate buffer (pH 6.5); and solvent B, acetonitrile. The recoveries were in the range of 86.0-102.3% with RSD of no more than 3.6%. The correlation coefficients of six analytes were high (r(2) ≥ 0.9988) and within the test ranges. The limits of detection and quantification for the investigated compounds were lower, at 0.36-0.68 and 1.22-2.30 mg/kg, respectively. The overall intra- and interday RSDs were no more than 1.8%. The developed method was successfully applied to the analysis of the analytes in samples. The results showed that ATP in RJ sequentially degrades to ADP, AMP, IMP, HxR, and Hx during storage.

  7. Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease

    PubMed Central

    Wang, Xiaoxia; Cao, Min; Dong, Yuqing

    2016-01-01

    Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders. PMID:27472466

  8. Thomas Birch's ‘Weekly Letter’ (1741–66): correspondence and history in the mid-eighteenth-century Royal Society

    PubMed Central

    Ellis, Markman

    2014-01-01

    Thomas Birch (1705–66), Secretary of the Royal Society from 1752 to 1765, and Philip Yorke, second Earl of Hardwicke (1720–90), wrote a ‘Weekly Letter’ from 1741 to 1766, an unpublished correspondence of 680 letters now housed in the British Library (Additional Mss 35396–400). The article examines the dimensions and purposes of this correspondence, an important conduit of information for the influential coterie of the ‘Hardwicke circle’ gathered around Yorke in the Royal Society. It explores the writers' self-conception of the correspondence, which was expressed in deliberately archaic categories of seventeenth-century news exchange, such as the newsletter, aviso and a-la-main. It shows how the letter writers negotiated their difference in status through the discourse of friendship, and concludes that the ‘Weekly Letter’ constituted for the correspondents a form of private knowledge, restricted in circulation to their discrete group, and as such unlike the open and networked model of Enlightenment science. PMID:25254279

  9. Case series of pectoralis major rupture requiring operative intervention sustained on the Royal Marines ‘Tarzan’ assault course

    PubMed Central

    Smith, Chris; Guyver, Paul Michael

    2015-01-01

    We present (with intra-operative imaging) four patients who sustained pectoralis major (PM) ruptures on the same piece of equipment of the ‘Tarzan’ assault course at the Commando Training Centre, Royal Marines (CTCRM). Recruits jump at running pace, carrying 21 lbs of equipment and a weapon (8 lbs) across a 6-feet gap onto a vertical cargo-net. The recruits punch horizontally through the net, before adducting their arm to catch themselves, and all weight, on their axilla. All patients presented with immediate pain and reduced function. Two had ruptures demonstrated on magnetic resonance imaging, one on an ultrasound scan and one via clinical examination. All four patients were found, at operation, to have sustained type IIIE injuries. All patients underwent PM repair using a unicortical button fixation and had an uneventful immediate postoperative course. Patient 1 left Royal Marines training after the injury (out of choice; not because of failure to rehabilitate). All other patients are under active rehabilitation, hoping to return to training. Review of 10 years of records at CTCRM reveal no documented PM rupture prior to our first case in October 2013. There has been no change to the obstacle or technique used and all patients deny the use of steroids. PMID:27582974

  10. Texas Heart Institute

    MedlinePlus

    ... Texas Heart Institute, The University of Texas Health Science Center at Houston, MD Anderson Cancer Center, and The University of Houston. Held most ... for Physicians Fellowships & Residencies School ...

  11. Development and validation of a multiclass method for the quantification of veterinary drug residues in honey and royal jelly by liquid chromatography-tandem mass spectrometry.

    PubMed

    Jin, Yue; Zhang, Jinzhen; Zhao, Wen; Zhang, Wenwen; Wang, Lin; Zhou, Jinhui; Li, Yi

    2017-04-15

    The aim of this study was to develop an analytical method for the analysis of a wide range of veterinary drugs in honey and royal jelly. A modified sample preparation procedure based on the quick, easy, cheap, effective, rugged and safe (QuEChERS) method was developed, followed by liquid chromatography tandem mass spectrometry determination. Use of the single sample preparation method for analysis of 42 veterinary drugs becomes more valuable because honey and royal jelly belong to completely different complex matrices. Another main advantage of the proposed method is its ability to identify and quantify 42 veterinary drugs with higher sensitivity than reference methods of China. This work has shown that the reported method was demonstrated to be convenient and reliable for the quick monitoring of veterinary drugs in honey and royal jelly samples.

  12. Sir William Newbigging (1772-1852) and Patrick Newbigging (1813-1864)-father and son presidents of the Royal College of Surgeons of Edinburgh.

    PubMed

    Kaufman, Matthew H

    2004-11-01

    Sir William Newbigging was a surgeon to the Edinburgh Royal Infirmary from 1802. While a dextrous operator, he was regarded principally as an excellent general practitioner. He was President of the Royal College of Surgeons of Edinburgh 1814-16 and was knighted by Queen Victoria in 1838. He had five sons, four of whom followed him into the medical profession. Four of his sons died young-only Patrick outlived him. When Patrick returned from a Continental tour in 1842 he joined his father's general practice and when Sir William died in 1852 he took it over. From 1861 to 1863 he was also President of the Royal College of Surgeons of Edinburgh. His last few years were plagued by ill health and he died in 1864, shortly after his fiftieth birthday.

  13. 30 years of Arctic sea ice thickness measurements by Royal Navy submarines

    NASA Astrophysics Data System (ADS)

    Wadhams, P.; Hughes, N.; Rodrigues, J. M.; Toberg, N.

    2009-12-01

    Royal Navy submarines fitted with upward-looking sonars have been collecting sea ice thickness data in the Arctic Ocean since the early 1970s. These data sets provide unique information on the Arctic sea ice thickness distribution and the way it has been changing in the past decades. In March 2007 HMS Tireless conducted a transect of the Arctic Ocean from Fram Strait to the western Beaufort Sea which gave the opportunity to measure the thickness of the sea ice cover during the winter immediately preceding the exceptional retreat of summer 2007. Three years earlier, in April 2004, a voyage by the same submarine took sea ice thickness data in the regions of Fram Strait, the Lincoln Sea and the North Pole. We report on the ice draft, pressure ridge and lead distributions obtained in these two cruises and analyse the evolution of the ice cover from 2004 to 2007 in areas of coincident tracks. In the region from north of Fram Strait to Ellesmere Island (about 85°N, 0-70°W) we find no change in mean drafts between 2004 and 2007 although there is a change in ice composition, with more ridging in 2007 and a slight reduction of modal draft. This agrees with the concept of young ice being driven towards Fram Strait. The region north of Ellesmere Island continues to be a "redoubt" of very thick deformed multiyear ice. In 2007 the submarine profiled extensively under the DAMOCLES ice camp at about 85°N 64°W and under the SEDNA ice camp at about 73°N 145°W. The latter is in the same location as the 1976 AIDJEX ice camp and a sonar survey done by a US submarine in April 1976. We found that a large decrease in mean draft had occurred (32%) over 31 years and that in 2007 the SEDNA region contained the thinnest ice of any part of the Arctic surveyed by the submarine. Under the DAMOCLES ice camp about 200km of topographic sea ice data were gathered with a Kongsberg EM3002 multibeam (MB) sonar, making this the largest continuous data set of its kind. The MB data produce high

  14. The EUI Data Center at the Royal Observatory of Belgium: challenges and solutions

    NASA Astrophysics Data System (ADS)

    Verbeeck, Cis; Stegen, Koen; Berghmans, David; West, Matthew; Kraaikamp, Emil; Gissot, Samuel; Giordanengo, Boris; Nicula, Bogdan

    ESA’s Solar Orbiter mission is conceived to perform a close-up study of the Sun and the inner heliosphere. With a perihelion close at 0.29 AU and a maximum aphelion at about 0.85 AU, Solar Orbiter ventures closer to the Sun than any spacecraft before. Furthermore, about 3 years after launch, the spacecraft will begin an out-of-ecliptic phase, with inclinations gradually increasing up to 30 degrees. Solar Orbiter will be launched in 2017 and its nominal mission will last until 2024 (with the possibility of an extended mission until 2026). It will provide unique data and imagery of the Sun. The Extreme Ultraviolet Imager (EUI) suite onboard Solar Orbiter is composed of two High Resolution Imagers (HRI, one at Lyman-alpha and one at 174 Angstrom), and one dual band Full-Sun imager (FSI) working alternatively at the 174 and 304 Angstrom EUV passbands. The EUI Data Center (EDC), under PI supervision and located at the Royal Observatory of Belgium (Brussels), will be the single point of contact for instrument planning activities and for data deliveries to the Solar Orbiter archive at ESAC (Madrid), and is currently in its design phase. The EUI Data Center will be responsible for delivery to ESAC and the maintenance of the pipeline software that will process EUI data from telemetry packets to higher level data products. It will also ensure the delivery of these data products to the Solar Orbiter Data Archive, and maintain the instrument user manual that documents the processing of EUI non-science TM packets at ESOC (Darmstadt). The EDC will monitor any anomaly affecting the EUI instrument and produce on a regular basis the Instrument Operations Reports including an instrument health and science performance review. Here, we present an overview of the EDC and how it envisages to tackle some specific challenges. Since EUI will only observe during three “science windows” of 10 days each per orbit of about 165 days and in view of a severely limited telemetry, it is

  15. Noise and exposure of personnel aboard vessels in the Royal Norwegian Navy.

    PubMed

    Sunde, Erlend; Irgens-Hansen, Kaja; Moen, Bente E; Gjestland, Truls; Koefoed, Vilhelm F; Oftedal, Gunnhild; Bråtveit, Magne

    2015-03-01

    Despite awareness of noise aboard vessels at sea, few studies have reported measured noise levels aboard ships. This study aimed to describe the noise levels aboard vessels in the Royal Norwegian Navy (RNoN), and to assess the noise exposure of personnel aboard RNoN vessels. In 2012/2013 noise measurements were conducted aboard 14 RNoN vessels from four different vessel classes (frigates, coastal corvettes, mine vessels, and coast guard vessels) which were included in this study. Mean and median A-weighted noise levels (L p,A) in decibel (dB(A)) were calculated for different locations in each vessel class. The noise exposure of RNoN personnel was assessed by dosimeter measurements, and with a task-based (TB) strategy. The TB strategy used means of area measured noise levels in locations and the personnel's mean reported time spent in the respective locations to estimate the exposure. Area measurements of noise during sailing with typical operating modes, showed that for all vessel classes the noise levels were high in engine rooms with median L p,A ranging from 86.4 to 105.3 dB(A). In all the other locations the vessel class with the highest noise levels (coastal corvettes) had a median L p,A ranging from 71.7 to 95.0 dB(A), while the vessel class with the lowest noise levels (coast guard vessels) had a median L p,A ranging from 41.5 to 57.8 dB(A). For all vessel classes the engineers and electricians had amongst the highest 24-hour noise exposure (L p,A,24h), both before and after adjusting for estimated use of hearing protective devices (L p,A,24h > 67.3 dB(A)). The vessel class with the highest personnel exposure levels (coastal corvettes) had L p,A,24h ranging from 76.6 to 79.3 dB(A). The vessel class with the lowest personnel exposure levels (coast guard vessels) had an L p,A,24h ranging from 47.4 to 67.3 dB(A). In general, the dosimeter measurements gave higher exposure levels than those estimated with the TB strategy. All vessel classes, except the coast

  16. Advanced Operational Aviation Medicine Course, (4th), held at Royal Air Force Institute of Aviation Medicine, Farnborough, Hampshire on 17-26 June 1975

    DTIC Science & Technology

    1976-05-01

    possible. A life raft with an inflatable floor and a canopy provides good protection against -i chill. Frequent practice drills and experience of the...and equLpeant that will protect him from the coldl but military experience has shown that succems In such adverse onditions depends far nor* upon the...under such extreme conditions comes mainly from experience and training in that particular environmant and inKprovevents in mental and manual

  17. Annotated type catalogue of the Orthalicoidea (Mollusca, Gastropoda) in the Royal Belgian Institute of Sciences, Brussels, with descriptions of two new species

    PubMed Central

    Breure, Abraham S.H.

    2011-01-01

    Abstract The type status is described of 57 taxa from the superfamily Orthalicoidea in the collection of the Brussels museum. Two new species are described: Stenostylus perturbatus sp. n., and Suniellus adriani sp. n. New lectotypes are designated for Bulimulus (Naesiotus) amastroides Ancey, 1887; Bulimulus blanfordianus Ancey, 1903; Bulimulus montivagus chacoensis Ancey, 1897; Bulimus coloratus Nyst, 1845; Plecochilus dalmasi Dautzenberg, 1900; Placostylus porphyrostomus elata Dautzenberg, 1923; Bulimulus ephippium Ancey, 1904; Bulimus fulminans Nyst, 1843; Bulimus funckii Nyst, 1843; Orphnus thompsoni lutea Cousin, 1887; Bulimus melanocheilus Nyst, 1845; Orphnus thompsoni nigricans Cousin, 1887; Orphnus thompsoni olivacea Cousin, 1887; Bulimulus pollonerae Ancey, 1897; Orphnus thompsoni zebra Cousin, 1887. New combinations are: Bostryx borellii (Ancey, 1897); Bostryx carandaitiensis (Preston, 1907); Protoglyptus mazei (Crosse, 1874); Kuschelenia (Vermiculatus) sanborni (Haas, 1947). New synonymies are established for the following nominal taxa: Orphnus thompsoni var. lutea Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845); Orphnus thompsoni var. nigricans Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845); Thaumastus nystianus var. nigricans Cousin, 1887 = Drymaeus (Drymaeus) nystianus (Pfeiffer, 1853); Orphnus thompsoni var. olivacea Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845); Orphnus thompsoni var. zebra Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845). PMID:21747669

  18. Potential interoperability problems facing multi-site radiation oncology centers in The Netherlands

    NASA Astrophysics Data System (ADS)

    Scheurleer, J.; Koken, Ph; Wessel, R.

    2014-03-01

    Aim: To identify potential interoperability problems facing multi-site Radiation Oncology (RO) departments in the Netherlands and solutions for unambiguous multi-system workflows. Specific challenges confronting the RO department of VUmc (RO-VUmc), which is soon to open a satellite department, were characterized. Methods: A nationwide questionnaire survey was conducted to identify possible interoperability problems and solutions. Further detailed information was obtained by in-depth interviews at 3 Dutch RO institutes that already operate in more than one site. Results: The survey had a 100% response rate (n=21). Altogether 95 interoperability problems were described. Most reported problems were on a strategic and semantic level. The majority were DICOM(-RT) and HL7 related (n=65), primarily between treatment planning and verification systems or between departmental and hospital systems. Seven were identified as being relevant for RO-VUmc. Departments have overcome interoperability problems with their own, or with tailor-made vendor solutions. There was little knowledge about or utilization of solutions developed by Integrating the Healthcare Enterprise Radiation Oncology (IHE-RO). Conclusions: Although interoperability problems are still common, solutions have been identified. Awareness of IHE-RO needs to be raised. No major new interoperability problems are predicted as RO-VUmc develops into a multi-site department.

  19. Taming the fear of voice: Dilemmas in maintaining a high vaccination rate in the Netherlands.

    PubMed

    Geelen, Els; van Vliet, Hans; de Hoogh, Pieter; Horstman, Klasien

    2016-03-01

    In the context of international public debates on vaccination the National Institute for Public Health and the Environment (RIVM), the Dutch public health body responsible for the National Immunization Programme (NIP), fears that the high vaccination rate of children in the Netherlands obscures the many doubts and criticisms parents may have about vaccination. The question arises as to how the robustness of this vaccination rate and the resilience of the NIP can be assessed. To answer this question, we explore the vaccination practices and relationships between professionals and parents using qualitative methods. Drawing on Hirschman's concepts of exit, voice and loyalty, we distinguish between two different approaches to vaccination: one which enforces parental loyalty to the vaccination programme, and one which allows for voice. The analysis shows that due to their lack of voice in the main vaccination setting, parents' considerations are unknown and insight into their loyalty is lacking. We argue that the Dutch vaccination programme is caught between the insecurity of enforced parental loyalty to the NIP and the insecurity of enabling parental voice and negotiating space. We conclude that to increase the resilience of the NIP, experimenting with voice and exit is inevitable.

  20. [Veterinary assistance to dairy farms in the Netherlands: an assessment of the situation by dairy farmers].

    PubMed

    Lievaart, J J; Noordhuizen, J P

    1999-12-15

    A questionnaire-based study was conducted among 466 dairy farmers in the Netherlands. The study investigated the experiences and opinions of dairy farmers about veterinary herd health and production management programmes. The dairy farmers were selected at random, and thus some took part in such programmes whereas others did not. The questionnaire comprised general questions about the farm operation and specific questions about the herd health programme and the practice conducting it, as well as perceived advantages and disadvantages of the veterinary programme. Farmers who did not participate in such programmes were questioned about their reasons for not participating. Both groups were questioned about future perspectives and opportunities. The costs of the programme appeared to be a drawback for participation but not as much as perceived by the practices. According to farmers, programmes focus too much on curative aspects and too little on analysis or prevention, where the needs are. Farm areas not included in the programme are so far not yet covered by other institutions, contrary to the expectations of the veterinarians. In the future, the farmers would be willing to take part in similar or expanded programmes, provided that certain conditions, such as product definition, structure, planning, costs, are properly met.