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Sample records for royal netherlands institute

  1. Digitising the Past: The Beginning of a New Future at the Royal Tropical Institute of The Netherlands

    ERIC Educational Resources Information Center

    Levi, Peter

    2010-01-01

    Purpose: The purpose of this paper is to describe a project to digitise maps at the Royal Tropical Institute, or Koninklijk Instituut voor de Tropen (KIT), of The Netherlands. KIT has an extensive collection of maps and nautical charts of (sub-) tropical regions, including general maps and topographical map series, city maps, thematic maps and…

  2. Digitising the Past: The Beginning of a New Future at the Royal Tropical Institute of The Netherlands

    ERIC Educational Resources Information Center

    Levi, Peter

    2010-01-01

    Purpose: The purpose of this paper is to describe a project to digitise maps at the Royal Tropical Institute, or Koninklijk Instituut voor de Tropen (KIT), of The Netherlands. KIT has an extensive collection of maps and nautical charts of (sub-) tropical regions, including general maps and topographical map series, city maps, thematic maps and…

  3. Netherlands Maritime Institute

    ERIC Educational Resources Information Center

    Hoefsmit, R. G. A.

    1976-01-01

    Account of the aims and activities of the Netherlands Maritime Institute provided by the Secretary to the Institute's Board of Directors, The Institute's intent is "to promote maritime activities, including the shipbuilding-shipping relationship, in the broadest sense of the word." (Editor/RK)

  4. Je Maintiendrai: The Royal Netherlands Army Within the Alliance

    DTIC Science & Technology

    1989-06-01

    participated in combat from 1950 13 to 1953. 23 Tensions between the Netherlands and Indonesia resulted in several armed confrontations between the Dutch Army...van Hoof, "Fortifications in the Netherlands (c. 1500-1940)," Je Maintiendrai., 197-123; and Gerald Newton, The Netherlands: A Historical and Cultural ...KNIL became known as a "foreign legion." While trying to maintain at least a ratio of 1 European to 3 natives (usually Ambonese or Javanese ), the

  5. Neuropsychometric Test in Royal Netherlands Navy Mine-Clearance Divers

    DTIC Science & Technology

    2001-06-01

    1780 CA Den Helder, The Netherlands, tel +31 223 653214, fax +31 223 653148, e -mail ravhulst @wxs.nl 2 TNO Nutrition and Food Research, P.O.Box 360...3700 AJ Zeist, The Netherlands, tel +31 30 694615, fax +31 30 6944422, e -mail emmen@voeding.tno.nl Background: In recent years, there has been growing...Digit Memo Sjan Test (F/B DMST-F/B Learnin /memoie Paper presented at the RTO HFM Symposium on "Operational Medical Issues in Hypo- and Hyperbaric

  6. Meeting Report: Patrick Moore at the Royal Institution

    NASA Astrophysics Data System (ADS)

    Arditti, D.

    2010-02-01

    'Developments in amateur astronomy: past, present and future'. A special meeting in honour of Sir Patrick Moore to celebrate his 75 years as a BAA member, held on 2009 November 21 at the Royal Institution of Great Britain, Albemarle Street, London W1

  7. Humphry Davy and the Royal Institution of Great Britain.

    PubMed

    Unwin, Patrick R; Unwin, Robert W

    2009-03-20

    The abortive attempts of Sir Humphry Davy to introduce modest reforms at the Royal Society of London during his Presidency (1820-27) contrast with his (largely unstudied) earlier experience of administration at the Royal Institution of Great Britain (RI). Davy's attempts to combat the systemic weaknesses in governance and funding, and his role in effecting changes at the RI, in association with a core group of reformers, merit consideration. This paper analyses important aspects of the early management and social structure of the RI and examines the inner workings of the institution. It shows how and why the Library, its most valuable financial asset, and its celebrated Laboratory, developed along distinctive lines, each with its own support structures and intra-institutional interests. While acknowledging the roles traditionally ascribed to Count Rumford and Sir Joseph Banks, the paper highlights the contributions of other early patrons such as Thomas Bernard, son of a colonial governor of Massachusetts, and Earl Spencer, a leading European bibliophile and RI President from 1813 to 1825. The promotion of a Bill in Parliament in 1810, designed to transform the RI from a proprietary body politic into a corporation of members, and the subsequent framing of the bye-laws, provided opportunities to establish a more democratic structure of elected committees for the conduct of science.

  8. Humphry Davy, nitrous oxide, the Pneumatic Institution, and the Royal Institution.

    PubMed

    West, John B

    2014-11-01

    Humphry Davy (1778-1829) has an interesting place in the history of respiratory gases because the Pneumatic Institution in which he did much of his early work signaled the end of an era of discovery. The previous 40 years had seen essentially all of the important respiratory gases described, and the Institution was formed to exploit their possible value in medical treatment. Davy himself is well known for producing nitrous oxide and demonstrating that its inhalation could cause euphoria and heightened imagination. His thinking influenced the poets Samuel Taylor Coleridge and William Wordsworth, and perhaps we can claim that our discipline colored the poetry of the Romantic Movement. Davy was also the first person to measure the residual volume of the lung. The Pneumatic Institution was the brainchild of Thomas Beddoes, who had trained in Edinburgh under Joseph Black, who discovered carbon dioxide. Later Davy moved to the Royal Institution in London formed, in part, to diffuse the knowledge of scientific discoveries to the general public. Davy was a brilliant lecturer and developed an enthusiastic following. In addition he exploited the newly described electric battery to discover several new elements. He also invented the safety lamp in response to a series of devastating explosions in coal mines. Ultimately Davy became president of the Royal Society, a remarkable honor for somebody with such humble origins. Another of his important contributions was to introduce Michael Faraday (1791-1867) to science. Faraday became one of the most illustrious British scientists of all time.

  9. Killers in the Brain - Essays in Science and Technology from the Royal Institution

    NASA Astrophysics Data System (ADS)

    Day, Peter

    1999-09-01

    This fascinating and diverse selection of essays from the Royal Institution provides a glimpse of some of the most current and exciting scientific research, ranging from the global increase in asthma and allergies to neurodegenerative diseases known as "brain killers."

  10. Degenerative changes of the spine of fighter pilots of the Royal Netherlands Air Force (RNLAF).

    PubMed

    Hendriksen, I J; Holewijn, M

    1999-11-01

    The aim of this study was to examine whether F-16 pilots are at an increased risk of (cervical) spine degeneration. Retrospectively, X-ray slides were examined of pilots of the Royal Netherlands Air Force who were systematically radiographed (at least twice). In total, 316 pilots were evaluated: 188 F-16 pilots and 128 pilots in the control group. Two radiologists, who were blinded as to whether the X-ray films were of F-16 pilots or the control group, examined these X-rays separately. In both groups, the time between the two X-rays was on average 6 yr. Though the inter-rater agreement of the X-rays was rather low, both radiologists found comparable statistically significant differences between the two groups. In the F-16 group, an increased osteophytic spurring was found at levels C4-C5 and C6-C7, and increased arthrosis deformans was found in the cervical spine. Further analysis of the data of a selected group of pilots, whereby the difference in age between both groups was minimized, showed that the higher mean age of the F-16 pilots was possibly correlated with the increased degeneration in this group. No consistent relationship was found between spinal degeneration and initial radiological status. Also, a clear relationship between spinal degeneration and flying hours could not be demonstrated. These findings suggest that frequent exposure to high +Gz forces might cause premature degeneration of the spine of F-16 pilots. Future research must demonstrate to what extent age, mission, and number of flying hours have influenced the results. An uniform international classification and coding system in combination with establishing an international database is recommended.

  11. Integrating Social Sustainability in Engineering Education at the KTH Royal Institute of Technology

    ERIC Educational Resources Information Center

    Björnberg, Karin Edvardsson; Skogh, Inga-Britt; Strömberg, Emma

    2015-01-01

    Purpose: The purpose of this paper is to investigate what are perceived to be the main challenges associated with the integration of social sustainability into engineering education at the KTH Royal Institute of Technology, Stockholm. Design/methodology/approach: Semi-structured interviews were conducted with programme leaders and teachers from…

  12. Progress Report of Computerized I&D Services at the Royal Institute of Technology, Stockholm.

    ERIC Educational Resources Information Center

    Tell, Bjorn; Gluchowicz, Zofia

    During the five years of activities the documentation centre at the Royal Institute of Technology has established itself as an information centre in the fields of science and technology. The SDI service is now well implemented and its activities are used and appreciated by scientists, research workers and engineers at the universities, research…

  13. Integrating Social Sustainability in Engineering Education at the KTH Royal Institute of Technology

    ERIC Educational Resources Information Center

    Björnberg, Karin Edvardsson; Skogh, Inga-Britt; Strömberg, Emma

    2015-01-01

    Purpose: The purpose of this paper is to investigate what are perceived to be the main challenges associated with the integration of social sustainability into engineering education at the KTH Royal Institute of Technology, Stockholm. Design/methodology/approach: Semi-structured interviews were conducted with programme leaders and teachers from…

  14. Cosmic Rays - Essays in Science and Technology from the Royal Institution

    NASA Astrophysics Data System (ADS)

    Catlow, Richard; Greenfield, Susan

    2002-04-01

    Since its foundation in 1799, the Royal Institution of Great Britain has inspired enthusiasm and excitement for science, as a means to understanding the world around us. The Friday Evening Discourses were initiated by Michael Faraday in 1826 and are one of the most prestigious series of popular science lectures in the world.This new selection of essays from the Royal Institution offers fascinating and authoritative accounts of current thinking in diverse areas of science, ranging from cosmic rays to the development of new materials that seem to have a life of their own. Also in this collection are essays that consider how scientists can better convey their work to the general public and to a younger generation.

  15. [Health Institutions of the Hungarian and Imperial-Royal Armed Forces in the First World War].

    PubMed

    Kiss, Gábor

    2006-01-01

    The Military Health Institutes established during the World War I. aimed maintenance and recovery of soldiers' fighting value. Establishing an effective sanitary control was rather important, since the Hungarian Royal Honvéd Army attempted to prevent epidemics and diseases, especially venereal diseases and tuberculosis. The sanitary establishments consisted of three parts: they belonged to the operational area, to the provisional zone and to the homeland territory. These institutions were divided into permanent and temporary ones. Permanent sanitary institutions were the garrison hospitals; troop and military ("honvéd") hospitals and houses for invalids, while temporary sanitary establishments worked only in case of mobilization. In their arrangement not the distance was taken into consideration, but the potential for transport of the wounded. The Hungarian sanitary institutions proved to be rather successful in World War I.

  16. The importance of picking Porter: the Royal Institution, George Porter and the two cultures, 1959–64

    PubMed Central

    Cole, Rupert

    2015-01-01

    This paper examines the cultural reasons why in 1964 the Royal Institution (RI) selected George Porter, who became the only person so far to have been Director of the Royal Institution (1966–85), President of the Royal Society (1985–90) and President of the British Association (1985–86) at the same time, to succeed William Lawrence Bragg as the institution's scientific director and resident professor. Porter was established as first choice by an inner group of RI Managers before the formal selection process began. In this article I argue that Porter won their favour by presenting himself, during his tenure as the RI's Professor of Chemistry (1963–66), as a candidate who fitted well with the Managers' ideas about the future role of the RI—ideas that were deeply influenced by the prevailing technocratic visions of ‘science and society’, particularly C. P. Snow's writings on the ‘two cultures’.

  17. Reprint of "Egon Matijević and The Royal Institution" [J. Colloid Interface Sci. 309 (2007) 189-191].

    PubMed

    Thomas, John Meurig

    2007-06-15

    The background to the Faraday Evening Discourse given by Egon Matijević in 1989, as well as its impact, is outlined, and so also is his participation in the special Faraday Discussion convened at the Royal Institution in September, 1991 to mark the bicentennial of Michael Faraday's birth.

  18. Netherlands.

    PubMed

    1987-09-01

    Focus in this discussion of the Netherlands is on the following: geography; the people; history; government; political conditions; the economy; foreign relations; defense; and relations between the Netherlands and the US. The Dutch, primarily of Germanic stock with some Gallo-Celtic mixture, have clung to their small homeland against the constant threat of destruction by the North Sea and recurrent invasions by the great European powers. Religion influences Dutch history, society, institutions, and attitudes and is closely related to political life but to a diminishing degree. The present constitution dates from 1848 and has been amended several times. The government, based on the principles of ministerial responsibility and parliamentary government common to most constitutional monarchies in Western Europe, is composed of 3 basic institutions: the crown (monarch, Council of Ministers, and Council of State); the States General (Parliament); and the courts. Catholics, Protestants, Labor, and Liberals are the groups which form the historical basis for the 3 main political parties. The Dutch economy is based on private enterprise. The government has little direct ownership or participation, but it heavily influences the economy. More than 45% of the gross national product is involved in government operations and social programs. Services, which account for half of the national income, are primarily in transport and financial areas, such as banking and insurance. Industrial activity provides about 19% of the national income and is dominated by the metalworking, oil refining, chemical, and food-processing industries. In the last several years Dutch economic growth has been limited by the world's general economic slowdown. After an average 2% growth in 1984-86, real growth in 1987 is estimated at 1.5%. For much of its modern history, the Netherlands pursued a neutralist foreign policy. The good relationship between the US and the Netherlands is based on close historical

  19. Royal Observatory, Edinburgh

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The Royal Observatory, Edinburgh (ROE) comprises the UK Astronomy Technology Centre (ATC) of the PARTICLE PHYSICS AND ASTRONOMY RESEARCH COUNCIL, and the University of Edinburgh's Institute for Astronomy....

  20. "Agricultural Chymistry is at present in it's infancy": The Board of Agriculture, The Royal Institution and Humphry Davy.

    PubMed

    James, Frank A J L

    2015-01-01

    In this paper I sketch the institutional interactions between the Board of Agriculture and the Royal Institution in the late eighteenth and early nineteenth centuries. This includes analysing the composition of memberships and committees of both bodies in which, inter alia, I challenge Morris Berman's account of their institutional relations. A key figure was Humphry Davy who, because of his career ambitions, occupied a slightly uncomfortable position as Professor of Chemistry to both organisations. Davy's lecture notebooks and his subsequent publication Elements of Agricultural Chemistry reveal that he drew almost all his direct knowledge of the subject from Britain and Ireland. Yet, despite such parochial shortcomings that might be expected of an infant science at time of war, the popularity of his book, particularly in North America, provided continuity between the end of the Board of Agriculture in 1822 and the start of the impact of Justus Liebig's work in the 1840s.

  1. Thomas Ferrar, MB, LRCSI (1797-1837): the absentee professor of surgery at the Royal Belfast Academical Institution.

    PubMed Central

    Froggatt, P.

    1996-01-01

    Thomas Ferrar was the second professor of surgery in the short-lived (1835-1849) medical school of the Royal Belfast Academical Institution. Appointed on 5 July 1836 he failed to turn up for the winter session and was accordingly discharged on 29 November. He died in Sligo in the following June aged 39. Nothing has been written about Ferrar who survives as a mere foot-note in Belfast medical history. The events leading to his dismissal are, however, unusual, equivocal, and worth recounting. The facts suggest that the Institution was clearly justified in its action but that Ferrar emerges with some credit for a certain if misplaced high-mindedness though overshadowed by his patent derelictions. Images Figure PMID:8979785

  2. A comparison between two systems for pre-employment medical assessment in the Royal Netherlands Army by a randomized, controlled study.

    PubMed

    de Raad, John; Redekop, W Ken

    2004-06-01

    In 1998, the basic medical requirements for the Royal Netherlands Army were introduced as a standard for the assessment of the medical suitability of military personnel, consisting of 43 dichotomized points of judgment. This system replaced the old physical capacity, upper limbs, locomotion, hearing, eyesight, and emotional and mental state system, based on the detection of diseases and infirmities. We compared the two different examination systems for their ability to identify suitable recruits. For the latter purpose, we used the two operational measures of availability and health care costs. We performed a randomized, controlled study in which 352 soldiers were monitored for 2 years after being declared fit by one of the pre-employment medical assessment systems in question and having passed their general military training. We found that the pre-employment medical assessment system was the dominant factor for predicting the number of days fit-for-duty, as well as for the health care costs incurred. Those declared fit by the new system showed a statistically significant higher mean number of days fit-for-duty (648 compared with 612) and incurred significantly lower mean health care costs (6396 compared with 746 Euro). In this study, we were not able to uncover the mechanism by which the "basic medical requirements" examination system led to an improvement in outcome. For the present, this mechanism is interpreted because of differences between the two systems.

  3. Netherlands Institute of Care and Welfare/NIZW: Source of Knowledge and Inspiration.

    ERIC Educational Resources Information Center

    Netherlands Inst. of Care and Welfare, Utrecht.

    Playing an important role in developing new social policies and introducing new methods, the Netherlands Institute of Care and Welfare (NIZW) is an independent foundation funded by a combination of private and public monies to conduct research and to develop and implement programs in five areas: (1) care and nursing; (2) organization of care; (3)…

  4. The motivations, institutions and organization of university-industry collaborations in the Netherlands.

    PubMed

    Bodas Freitas, Isabel Maria; Verspagen, Bart

    2017-01-01

    This study builds on the economics and organization literatures to explore whether and how institutions and organizational structure complement or substitute each other to create specific spaces of alignment where specific individual actors' motivations co-exist. Focusing on university-industry collaborations, the study examines whether and how different axes of alignment of university and industry motivations are integrated in projects with specific technological objectives and organizational structures, benefitting from the presence of specific institutions designed to facilitate collaboration. Empirically, the study relies on in-depth data on 30 university-industry collaborations in the Netherlands, and provides preliminary evidence that the technological objective and organizational structure of collaboration are malleable variables allowing the integration of both partners' objectives and expectations. Different institutional incentives for university-industry collaboration favor specific axes of alignment of motivations and certain types of collaborative projects' design. Hence, our exploratory results suggest that specific organizational and technological structures tend to prevail in the presence of specific institutions.

  5. Knowledge Transfer between SMEs and Higher Education Institutions: Differences between Universities and Colleges of Higher Education in the Netherlands

    ERIC Educational Resources Information Center

    Delfmann, Heike; Koster, Sierdjan

    2012-01-01

    Knowledge transfer (KT) between higher education institutions (HEIs) and businesses is seen as a key element of innovation in knowledge-driven economies: HEIs generate knowledge that can be adopted in the regional economy. This process of valorization has been studied extensively, mainly with a focus on universities. In the Netherlands, there is a…

  6. Changing Children’s Understanding of the Brain: A Longitudinal Study of the Royal Institution Christmas Lectures as a Measure of Public Engagement

    PubMed Central

    Gjersoe, Nathalia L.; Hood, Bruce

    2013-01-01

    Demonstrating the impact of public engagement is an increasingly important activity for today’s academics and researchers. The difficulty is that many areas of interest do not lend themselves well to evaluation because the impact of each single intervention can be hard to trace and take time to become manifest. With this in mind, we evaluated a lecture based around the 2011 Royal Institution Christmas Lectures, ”Meet Your Brain,” delivered to school children from low performing schools. We compared knowledge about four neuroscience facts one week before, one week after and six weeks after the lecture. Analysis revealed significant knowledge transfer one week after the lecture that was retained five weeks later. We conclude that public engagement through tailored lectures can have significant impact in the moderate term with the potential to leave a lasting impression over a longer period. PMID:24260513

  7. Changing children's understanding of the brain: a longitudinal study of the Royal Institution Christmas Lectures as a measure of public engagement.

    PubMed

    Gjersoe, Nathalia L; Hood, Bruce

    2013-01-01

    Demonstrating the impact of public engagement is an increasingly important activity for today's academics and researchers. The difficulty is that many areas of interest do not lend themselves well to evaluation because the impact of each single intervention can be hard to trace and take time to become manifest. With this in mind, we evaluated a lecture based around the 2011 Royal Institution Christmas Lectures, "Meet Your Brain," delivered to school children from low performing schools. We compared knowledge about four neuroscience facts one week before, one week after and six weeks after the lecture. Analysis revealed significant knowledge transfer one week after the lecture that was retained five weeks later. We conclude that public engagement through tailored lectures can have significant impact in the moderate term with the potential to leave a lasting impression over a longer period.

  8. New developments in EPID-based 3D dosimetry in The Netherlands Cancer Institute

    NASA Astrophysics Data System (ADS)

    Mijnheer, B.; Rozendaal, R.; Olaciregui-Ruiz, I.; González, P.; van Oers, R.; Mans, A.

    2017-05-01

    EPID-based offline 3D in vivo dosimetry is performed routinely in The Netherlands Cancer Institute for almost all RT treatments. The 3D dose distribution is reconstructed using the EPID primary dose in combination with a back-projection algorithm and compared with the planned dose distribution. Recently the method was adapted for real-time dose verification, performing 3D dose verification in less than 300 ms, which is faster than the current portal frame acquisition rate. In this way a possibility is created for halting the linac in case of large delivery errors. Furthermore, a new method for pre-treatment QA was developed in which the EPID primary dose behind a phantom or patient is predicted using the CT data of that phantom or patient in combination with in-air EPID measurements. This virtual EPID primary transit dose is then used to reconstruct the 3D dose distribution within the phantom or patient geometry using the same dose engine as applied offline. In order to assess the relevance of our clinically applied alert criteria, we investigated the sensitivity of our EPID-based 3D dose verification system to detect delivery errors in VMAT treatments. This was done through simulation by modifying patient treatment plans, as well as experimentally by performing EPID measurements during the irradiation of an Alderson phantom, both after deliberately introducing errors during VMAT delivery. In this presentation these new developments will be elucidated.

  9. 2D AND 3D dose verification at The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital using EPIDs

    NASA Astrophysics Data System (ADS)

    Mijnheer, Ben; Mans, Anton; Olaciregui-Ruiz, Igor; Sonke, Jan-Jakob; Tielenburg, Rene; Van Herk, Marcel; Vijlbrief, Ron; Stroom, Joep

    2010-11-01

    A review is given of the clinical use of EPID dosimetry in the Department of Radiation Oncology of The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital. All curative plans (almost all IMRT or VMAT) are verified with EPID dosimetry, mostly in vivo. The 2D approach for IMRT verification and the 3D method for VMAT verification are elucidated and their clinical implementation described. It has been shown that EPID dosimetry plays an important role in the total chain of verification procedures that are implemented in our department. It provides a safety net for advanced treatments such as IMRT and VMAT, as well as a full account of the dose delivered.

  10. A Q fever outbreak in a psychiatric care institution in The Netherlands.

    PubMed

    Koene, R P M; Schimmer, B; Rensen, H; Biesheuvel, M; de Bruin, A; Lohuis, A; Horrevorts, A; Lunel, F Verduyn; Delsing, C E; Hautvast, J L A

    2011-01-01

    In May 2008 the Nijmegen Municipal Health Service (MHS) was informed about an outbreak of atypical pneumonia in three in-patients of a long-term psychiatric institution. The patients had been hospitalized and had laboratory confirmation of acute Q fever infection. The MHS started active case finding among in-patients, employees of and visitors to the institution. In a small meadow on the institution premises a flock of sheep was present. One of the lambs in the flock had been abandoned by its mother and cuddled by the in-patients. Samples were taken of the flock. Forty-five clinical cases were identified in employees, in-patients and visitors; 28 were laboratory confirmed as Q fever. Laboratory screening of pregnant women and persons with valvular heart disease resulted in one confirmed Q fever case in a pregnant woman. Of 27 samples from animals, seven were positive and 15 suspect for Coxiella burnetii infection. This outbreak of Q fever in a unique psychiatric setting pointed to a small flock of sheep with newborn lambs as the most likely source of exposure. Care institutions that have vulnerable residents and keep flocks of sheep should be careful to take adequate hygienic measures during delivery of lambs and handling of birth products.

  11. Thank you, Royal Society

    NASA Astrophysics Data System (ADS)

    Toumey, Chris

    2015-04-01

    More than a decade after it was first published, Chris Toumey revisits a report from the Royal Society on the opportunities and uncertainties of nanotechnology, and finds that it still has plenty to offer.

  12. European Standards for Quality Assurance and Institutional Practices of Student Assessment in the UK, the Netherlands and the Czech Republic

    ERIC Educational Resources Information Center

    Kohoutek, Jan

    2014-01-01

    This article analyses the student assessment procedures of 12 universities in the UK, the Netherlands and the Czech Republic with respect to their alignment with the European standards and guidelines on the quality of assessing higher education students (European Standards and Guidelines for Quality Assurance [ESG] 1.3). Based on qualitative…

  13. European Standards for Quality Assurance and Institutional Practices of Student Assessment in the UK, the Netherlands and the Czech Republic

    ERIC Educational Resources Information Center

    Kohoutek, Jan

    2014-01-01

    This article analyses the student assessment procedures of 12 universities in the UK, the Netherlands and the Czech Republic with respect to their alignment with the European standards and guidelines on the quality of assessing higher education students (European Standards and Guidelines for Quality Assurance [ESG] 1.3). Based on qualitative…

  14. Changes in admission to long-term care institutions in the Netherlands: comparing two cohorts over the period 1996-1999 and 2006-2009.

    PubMed

    Alders, Peter; Comijs, Hannie C; Deeg, Dorly J H

    2017-06-01

    Using data from two cohorts, we examine to what extent a decline in institutional care in the Netherlands is associated with changes in the need for care and/or societal factors. We compared older adults, aged 65-89, who were admitted to a long-term care (LTC) institution in the period 1996-1999 and 2006-2009. Using the Andersen model, we tested per block of predisposing, enabling and need factors, which factors were significant predictors of admission to institutional care. With a Blinder-Oaxaca decomposition regression, we decomposed the difference in admission to an LTC institution between the period 1996-1999 and 2006-2009 into a part that is due to differences in health needs and other factors such as effect of policy, social values, and technology. Between 1996 and 2006, the percentage of co-residing partners and income increased and the average level of loneliness decreased significantly. The prevalence of disability, chronic diseases, however, increased. Whereas the care by partners declined, the formal care by professionals increased. Although the observed decline in the admission rate to institutional care was relatively small across the 10 years (from 5.3 % in 1996-1999 to 4.5 % in 2006-2009, a 15 % decrease), the probability of admission in 2006-2009 was relatively much lower when accounting for changes in the health and social conditions of the participants: the probability was 1.7-2.1 % point lower for adults in the period 2006-2009 compared to 1996-1999, a 32-40 % decrease. Our results show that the decline in the admission rate to LTC institutions is not the result of changes in need. The decline is suggested to be the combined effect of changes in policy, technological advances and changes in social norms.

  15. [Forensic assessments from the Netherlands Institute of Forensic Psychiatry and Psychology in retrospect; applications of genetics and neuroscience, in 2000 and 2009].

    PubMed

    Ter Harmsel, J F; Molendijk, T; van El, C G; M'charek, A; Kempes, M; Rinne, T; Pieters, T

    2016-01-01

    Developments in neurosciences and genetics are relevant for forensic psychiatry. To find out whether and how genetic and neuroscientific applications are being used in forensic psychiatric assessments, and, if they are, to estimate to what extent new applications will fit in with these uses. We analysed 60 forensic psychiatric assessments from the Netherlands Institute of Forensic Psychiatry and Psychology, Pieter Baan Center, and 30 non-clinical assessments from 2000 and 2009. We found that (behavioral) genetic, neurological and neuropsychological applications played only a modest role in forensic psychiatric assessment and they represent different phases of the implementation process. Neuropsychological assessment already occupied a position of some importance, but needed to be better integrated. Applications from neurology were still being developed. Clinical genetic assessment was being used occasionally in order to diagnose a genetic syndrome with behavioral consequences. If further validated information becomes available in the future, it should be possible to integrate new research methods more fully into current clinical practice.

  16. Cross-institutional Flood Forecasting in Regional Water Systems;Innovative application of Delft-FEWS in The Netherlands

    NASA Astrophysics Data System (ADS)

    van Heeringen, Klaas-Jan; Douben, Klaas-Jan; van de Wouw, Mark; IJpelaar, Ruben; van Loenen, Arnejan

    2015-04-01

    The regional water system in the North-Brabant province in The Netherlands is (operationally) managed by four different Water Authorities: Rijkswaterstaat Southern-Netherlands, and the three Regional Water Authorities (RWA's) Aa & Maas, De Dommel and Brabantse Delta. The water systems basically consist of mid-sized (navigable) canals, semi-natural brook valleys in mildly sloping sandy soils, and man-made watercourses in clayey polder areas. The management areas of the De Dommel and Brabantse Delta RWA's are bordering Belgium over a total length of approx. 185 km, and are prone to transboundary flood flows. The current project 'Dynamic Water Management' intends to improve the mutual cooperation and communication between the RWA's and Rijkswaterstaat during periods of both high and low water stages. The project deals with governance issues such as water agreements and water systems analyses. A powerful product of the project is a DSS for flood forecasting ('DSS Brabant'). One of the main benefits of cooperation between the RWA's and Rijkswaterstaat is to enable assistance during peak flows and flood events and to try to optimise operational water systems management by deploying drainage and storage facilities by using the connecting (navigable) canals. A set of hydraulic structures like pumps, weirs and sluices facilitate the control and routing of the water flows. Especially during peak flow and flood events, these canals allow to deviate excess flow to neighbours who suffer less from flooding. During regular conditions the water systems are fully independent, but during floods connections are made by using the canal system. The heart of DSS Brabant consists of a Delft-FEWS application, containing several RTC (1st) and hydrodynamic Sobek (2nd order) models FEWS is receiving a variety of data on hourly or six-hourly basis, consisting of measured and forecasted meteorological input (radar-precipitation/HIRLAM, evaporation and wind), water levels and discharges at

  17. [Anaphylaxis caused by royal jelly].

    PubMed

    Roger, A; Rubira, N; Nogueiras, C; Guspi, R; Baltasar, M; Cadahia, A

    1995-01-01

    Royal jelly is the food on which are fed and which causes them to develop into queen bees. It is claimed to have rejuvenating virtues for human beings. This report describes a 15-year-old atopic woman who presented, 15 minutes after the intake of royal jelly, local angioedema, generalised urticaria, dysphonia and bronchospasm. She was given antihistaminics and corticoesteroids and responded well. The ingested product contains royal jelly, lactose and potassium sorbate. No anaphylactic reactions to lactose and sorbates have been described previously. Prick test to common food allergens hymenoptera venoms and pollens were negative. RAST to meletin was also negative. Blood eosinophils were 600 and total IgE 465. Non-commercial prepared specific IgE to royal jelly was positive (0.8 KU/l). Prick by prick was positive to 1/10 dilution, being negative in controls (undiluted). No oral provocation test was performed due to the risk of anaphylaxis. No reported cases of royal jelly allergy were founded in a review of the medical literature. Concluding, it is the first described case of IgE anaphylactic reaction due to royal jelly.

  18. Experiences of home and institution in a secured nursing home ward in The Netherlands: A participatory intervention study.

    PubMed

    Klaassens, Mirjam; Meijering, Louise

    2015-08-01

    Nursing homes have been criticised for not providing a home for their residents. This article aims to provide insight into (1) the features of home and institution as experienced by residents and caregivers of a secured ward in a nursing home, and (2) how interventions implemented on the ward can contribute to a more home-like environment. For this purpose, a participatory intervention study, involving both caregivers and residents, was carried out. We collected data through qualitative research methods: observations, in-depth interviews and diaries to evaluate the interventions over time. We adopted an informed grounded theory approach, and used conceptualisations of total institutions and home as a theoretical lens. We found that the studied ward had strong characteristics of a total institution, such as batch living, block treatment and limited privacy. To increase the sense of home, interventions were formulated and implemented by the caregivers to increase the residents' autonomy, control and privacy. In this process, caregivers' perceptions and attitudes towards the provision of care shifted from task-oriented to person-centred care. We conclude that it is possible to increase the home-like character of a secured ward by introducing core values of home by means of interventions involving both caregivers and residents.

  19. Health-Related Fitness in the Royal Netherlands Army

    DTIC Science & Technology

    2009-10-01

    and at low prices. It was concluded that health promotion activities for this target group were beneficial, but only in concordance with a health...actually worry about chronic disease following these practices is often lacking. Therefore, messages for this target group should aim for the

  20. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread.

    PubMed

    Weterings, V; Zhou, K; Rossen, J W; van Stenis, D; Thewessen, E; Kluytmans, J; Veenemans, J

    2015-08-01

    We describe an outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-KP) ST258 that occurred in two institutions (a hospital and a nursing home) in the Netherlands between July and December 2013. In total, six patients were found to be positive for KPC-KP. All isolates were resistant to colistin and exhibited reduced susceptibility to gentamicin and tigecycline. In all settings, extensive environmental contamination was found. Whole genome sequencing revealed the presence of bla KPC-2 and bla SHV-12 genes, as well as the close relatedness of patient and environmental isolates. In the hospital setting, one transmission was detected, despite contact precautions. After upgrading to strict isolation, no further spread was found. After the transfer of the index patient to a nursing home in the same region, four further transmissions occurred. The outbreak in the nursing home was controlled by transferring all KPC-KP-positive residents to a separate location outside the nursing home, where a dedicated nursing team cared for patients. This outbreak illustrates that the spread of pan-resistant Enterobacteriaceae can be controlled, but may be difficult, particularly in long-term care facilities. It, therefore, poses a major threat to patient safety. Clear guidelines to control reservoirs in and outside the hospitals are urgently needed.

  1. [The infirmaries of ladies and servants in the Spanish royal court of the seventeenth century].

    PubMed

    Campos Diez, Soledad

    2002-01-01

    The object of the present institutional study is the help and health care received by ladies and servants of the palace in the Spanish royal court of the 17th century. The study draws on documents recorded under the heading "The Infirmary of Ladies and Servants" in file 447 of the administrative section at the General Records of the Madrid Royal Palace.

  2. Proteome analysis of Apis mellifera royal jelly.

    PubMed

    Schönleben, Simone; Sickmann, Albert; Mueller, Martin J; Reinders, Joerg

    2007-10-01

    Royal jelly plays a pivotal role in the development of honey bee larvae. However, while various health promoting properties of royal jelly have been reported, most of the active substances within royal jelly that lead to these properties are still unknown. Since up to 50% (dry mass) of royal jelly is protein, royal jelly proteome analysis is a promising starting point for attempts to identify the proteins that provide health-promoting effects. However, the comprehensive analysis of royal jelly proteins is hampered by the enormous abundance of some proteins in the major royal jelly protein family, which constitutes 80-90% of the royal jelly proteome. The high heterogeneity of these proteins is an additional challenge for proteomic analysis, since it necessitates the use of analytical techniques that provide high resolution and a wide dynamic range. The application of individual methods such as 2D-PAGE or multidimensional chromatography can only yield certain subpopulations of a proteome due to the specific bias of each method. We applied different methods for the prefractionation and separation of royal jelly proteins in order to circumvent the shortcomings of the individual techniques and achieve a high coverage of the royal jelly proteome. In this way, we were able to identify 20 different proteins in total, as well as to show a very high degree of cleavage of different proteins of the major royal jelly protein family. Furthermore, we investigated the protein phosphorylation of royal jelly proteins, and identified and located two phosphorylation sites within venom protein 2.

  3. Safety in Royal Filling Factories

    DTIC Science & Technology

    1950-10-01

    Risks to personnel at R.F.F.s - Clean conditions 6 - Fireproof clothing 5 - Protection from Explosion 4,5 - Protection against Lightning 5 Royal...Last War Accident Records New factory planning methods Industrial safety Section 3 METHODS General Safety principles Test of clothing Clean...Instruction (1799) B. Report on safety aspects of certain explosives by the Government Committee of 1914/18* C. Standard tests on D.B. clothing

  4. Netherlands Antilles.

    PubMed

    1983-10-01

    This discussion of the Netherlands Antilles focuses on the following: geography, the people, history, government, political conditions, economy, and foreign relations. In 1980 the population totaled 253,400 with an annual growth rate of 1%. The Netherlands Antilles consists of 2 groups of 3 islands each, situated in the Caribbean Sea about 880 kilometers apart. 40 nationalities are represented. Dutch is the official language, but Spanish and English are spoken widely. Alonzo de Ojeda, a Spanish navigator, landed on Curacao in 1499, and in 1527 the Spanish took possession of Curacao, Bonaire, and Aruba. In 1634 the 3 islands passed to the Netherlands, where they have remained except for 2 short periods during the Napoleonic wars when the British ruled at Willemstad. According to the statute of 1954, which serves as the constitution, the Netherlands Antilles has a constitutional and parliamentary form of government. The highest power in the Kingdom of the Netherlands is the sovereign, Queen Beatrix, who is represented in the Antilles by an appointed governor. The independent court system is under the control of the chief justice of the Supreme Court of Justice. Each of the island territories has its own representative body, the Island Council. Politics are dominated by 3 issues: economic problems, the prospect of independence, and Aruban separatism. The economic well-being of the Netherlands Antilles is based principally on the operations of 2 huge oil refineries. Because of the high volume of shipments in and out of the 2 islands, Curacao and Aruba ports are among the busiest in the world. Until recently, petroleum or petroleum products accounted for about 85% of the dollar volume of imports and exports from the Netherlands Antilles. That figure has declined with the worldwide oil glut, and the refineries are using only 50-60% of capacity. The next most important industries are tourism and offshore investment and banking. The per capita income in the Antilles is one

  5. A History of Navigation in The Royal Air Force from the 60s to the 80s: ?The Last Days of Airborne Analogue Computing?

    NASA Astrophysics Data System (ADS)

    Bonnor, Norman

    This paper is based on a presentation at a seminar on the History of Navigation in the Royal Air Force, held at The Royal Air Force Museum, Hendon, on 21 October 1996. The seminar was organized by the Royal Air Force Historical Society in Association with the Guild of Air Pilots and Air Navigators and the Royal Institute of Navigation. The complete proceedings of the seminar are being published in 1997.

  6. Reviews Book: Voyage to the Heart of the Matter: The ATLAS Experiment at CERN Equipment: SEP Spectroscope Books: Quantum Gods / The Universe Places to visit: The Royal Institution of Great Britain Book: What is this Thing Called Science? Book: Don't be Such a Scientist: Talking Substance in the Age of Style Equipment: La Crosse Anemometer Book: Wonder and Delight Web Watch

    NASA Astrophysics Data System (ADS)

    2010-05-01

    WE RECOMMEND SEP Spectroscope Flatpacked classroom equipment for pupils aged 10 and over Quantum Gods Book attacks spiritualism and religion with physics The Universe Study of whether physics alone can explain origin of universe La Crosse Anemometer Handheld monitor is packed with useful features Wonder and Delight Essays in science education in honour of Eric Rogers WORTH A LOOK Voyage to the Heart of the Matter: The ATLAS Experiment at CERN Pop-up book explains background to complex physics The Royal Institution of Great Britain RI museum proves interesting but not ideal for teaching What is this Thing Called Science? Theory and history of science in an opinionated study Don't be Such a Scientist: Talking Substance in the Age of Style Explanation of how science is best communicated to the public WEB WATCH Particle physics simulations vary in complexity, usefulness and how well they work

  7. The Netherlands.

    ERIC Educational Resources Information Center

    Oomen, Annemarie; de Vos, J. A. M.

    The labor market in the Netherlands is characterized by rapid economic and technological development. In response to this, a new approach to career development has been to expand individuals' career competencies. Education, employment policy, non-profit organizations, and corporate life are facing the task of developing career development services…

  8. Amsterdam, Netherlands

    NASA Image and Video Library

    2012-11-26

    Amsterdam is the largest city and the capital of the Netherlands. Its name derives from a dam in the river Amstel. Founded in the 12th century as a fishing village, Amsterdam was one of the most important ports in the world in the 17th century.

  9. [The insigne and suntuoso Royal Hospital of Granada (I). Royal foundations and the hospital regrouping (1501-1526)].

    PubMed

    Valenzuela Candelario, José

    2003-01-01

    In the 1520s the local authorities planned to set up a new modern hospital in the city of Granada by combining two existing Royal Hospitals: Alhambra and Reyes. As a public institution and as a new building, the new hospital could develop the mandates of the original foundation and extend its care to become a general hospital. In this way it would strengthen its status as a charitable undertaking and legacy of the Catholic Monarchs and, secondly, as a great architectural monument.

  10. "Should I Buy or Should I Grow?" How drug policy institutions and drug market transaction costs shape the decision to self-supply with cannabis in the Netherlands and the Czech Republic.

    PubMed

    Belackova, Vendula; Maalsté, Nicole; Zabransky, Tomas; Grund, Jean Paul

    2015-03-01

    This paper uses the framework of institutional economics to assess the impact of formal and informal institutions that influence the transaction costs on the cannabis market, and users' decisions to self-supply in the Czech Republic and the Netherlands, two countries with seemingly identical policies towards cannabis cultivation. A comparative analysis was conducted using secondary qualitative and quantitative data in four areas that were identified as relevant to the decision to cultivate cannabis: (i) the rules of the game - cannabis cultivation policy; (ii) "playing the game" - implementation of cannabis cultivation policy, (iii) informal institutions - cannabis cultivation culture, and (iv) the transaction costs of the cannabis market - availability, quality, and relative cannabis prices adjusted by purchasing power parity. Although the two policies are similar, their implementation differs substantially. In the Czech Republic, law enforcement has focused almost exclusively on large-scale cultivation. This has resulted in a competitive small-scale cultivation market, built upon a history of cannabis self-supply, which is pushing cannabis prices down. In the Netherlands, the costs of establishing one's own self-supply have historically outweighed the costs associated with buying in coffee shops. Additionally, law enforcement has recently pushed small-scale growers away from the market, and a large-scale cannabis supply, partly controlled by organised criminal groups, has been established that is driving prices up. The Czech cannabis prices have become relatively lower than the Dutch prices only recently, and the decision to buy on the market or to self-supply will be further shaped by the transactions costs on both markets, by policy implementation and by the local culture. The ability to learn from the impacts of cannabis cultivation policies conducted within the framework of UN drug treaties is particularly important at a time when increasing numbers of

  11. Lessons from the United Kingdom's Royal Society

    ERIC Educational Resources Information Center

    Allen, Henry Lee

    2010-01-01

    Celebrating its 350th anniversary as a scholarly association devoted to scientific pursuits, the Royal Society (UK), in March 2010, published "The Scientific Century: Securing Our Future Prosperity." In its report, the Royal Society argues against both the notion of withdrawing public investment from its world-class universities and the…

  12. Lessons from the United Kingdom's Royal Society

    ERIC Educational Resources Information Center

    Allen, Henry Lee

    2010-01-01

    Celebrating its 350th anniversary as a scholarly association devoted to scientific pursuits, the Royal Society (UK), in March 2010, published "The Scientific Century: Securing Our Future Prosperity." In its report, the Royal Society argues against both the notion of withdrawing public investment from its world-class universities and the…

  13. First-year evaluation of IMERG - Final Run in the Netherlands

    NASA Astrophysics Data System (ADS)

    Rios Gaona, Manuel Felipe; Overeem, Aart; Leijnse, Hidde; Uijlenhoet, Remko

    2016-04-01

    For almost two years now, the Global Precipitation Measurement (GPM) mission has provided worldwide satellite rainfall estimates at higher spatiotemporal resolutions than its predecessor TRMM (Tropical Rainfall Measurement Mission). Accurate rainfall estimates at higher resolutions are the main input in modeling physical processes relevant to society like floods, landslides, and weather extremes. Conversely to TRMM Multi-satellite Precipitation Analysis (TMPA) products, the Netherlands is within the coverage of GPM Level-3 products, i.e., IMERG (Integrated Multi-satellite Retrievals for GPM). The IMERG spatiotemporal resolution is 0.1° x 0.1° every 30 min (180°W to 180°E, and 60°N to 60°S), with latencies of 6, 18 hours and 4 months. Here we evaluate the first full year of the IMERG Day 1 Final Run over the land surface of the Netherlands. IMERG Final Run is considered the research product, and provides the longest public data set among IMERG products. We compare half-hourly and daily IMERG rainfall maps against Dutch gauge-adjusted radar rainfall maps. Radar rainfall maps are provided by the Royal Netherlands Meteorological Institute (KNMI), and are considered as the ground truth given its accuracy, spatiotemporal resolution and availability. In general, there is a tendency of GPM to underestimate rainfall intensities over the land surface of the Netherlands. Nevertheless, this underestimation is relatively low, which suggests a potential applicability of IMERG Final Run as a reliable source of rainfall estimates in diverse hydrological and hydrometeorological applications. The robustness and data availability of IMERG is an important asset, especially in places where rain gauge networks are scarce or poorly maintained, or where weather radar networks are too expensive to acquire and/or maintain.

  14. Persistent Identifiers for Dutch cultural heritage institutions

    NASA Astrophysics Data System (ADS)

    Ras, Marcel; Kruithof, Gijsbert

    2016-04-01

    Over the past years, more and more collections belonging to archives, libraries, media, museums, and knowledge institutes are being digitised and made available online. These are exciting times for ALM institutions. They are realising that, in the information society, their collections are goldmines. Unfortunately most heritage institutions in the Netherlands do not yet meet the basic preconditions for long-term availability of their collections. The digital objects often have no long lasting fixed reference yet. URL's and web addresses change. Some digital objects that were referenced in Europeana and other portals can no longer be found. References in scientific articles have a very short life span, which is damaging for scholarly research. In 2015, the Dutch Digital Heritage Network (NDE) has started a two-year work program to co-ordinate existing initiatives in order to improve the (long-term) accessibility of the Dutch digital heritage for a wide range of users, anytime, anyplace. The Digital Heritage Network is a partnership established on the initiative of the Ministry of Education, Culture and Science. The members of the NDE are large, national institutions that strive to professionally preserve and manage digital data, e.g. the National Library, The Netherlands Institute for Sound and Vision, the Netherlands Cultural Heritage Agency, the Royal Netherlands Academy of Arts and Sciences, the National Archive of the Netherlands and the DEN Foundation, and a growing number of associations and individuals both within and outside the heritage sector. By means of three work programmes the goals of the Network should be accomplished and improve the visibility, the usability and the sustainability of digital heritage. Each programme contains of a set of projects. Within the sustainability program a project on creating a model for persistent identifiers is taking place. The main goals of the project are (1) raise awareness among cultural heritage institutions on the

  15. Guide to postgraduate exams: Royal College exams.

    PubMed

    Holsgrove, G

    Postgraduate exams are important milestones (or barriers) in specialist careers. However, there are several peculiar features in the Royal Colleges' exams, and considerable differences between them. This is the first of three articles aimed at helping candidates make appropriate preparations.

  16. The influence of temperature and climate change on the timing of pollen release in the Netherlands

    NASA Astrophysics Data System (ADS)

    van Vliet, Arnold J. H.; Overeem, Aart; de Groot, Rudolf S.; Jacobs, Adrie F. G.; Spieksma, Frits T. M.

    2002-11-01

    In the last decade it has become clear that the timing of many phenological processes, like the start of flowering and leaf unfolding in spring, have changed. The increase in temperature is believed to be the main cause. The earlier start of flowering will have consequences for the start of the pollen season, and thus for the start of the hay fever season. Millions of people world-wide will therefore experience the impact of climate change in their daily lives during spring and summer. In this paper we analyse the relation between climate parameters, especially temperature, and the start of the pollen season in the western part of the Netherlands based on daily pollen counts of the Leiden University Medical Centre and temperature measurements from 1969 till 2000 by the Royal Netherlands Meteorological Institute in De Bilt. The results indicate that there is a strong correlation between temperature and start of the pollen season. An advance of the start of the pollen season of 3 to 22 days has been observed. The potential future changes in the start of the pollen season under climate change scenarios are also discussed.

  17. Multi-Dimensional Impact of the Public–Private Center for Translational Molecular Medicine (CTMM) in the Netherlands: Understanding New 21st Century Institutional Designs to Support Innovation-in-Society

    PubMed Central

    2016-01-01

    Abstract Knowledge translation is at the epicenter of 21st century life sciences and integrative biology. Several innovative institutional designs have been formulated to cultivate knowledge translation. One of these organizational innovations has been the Center for Translational Molecular Medicine (CTMM), a multi-million public–private partnership in the Netherlands. The CTMM aims to accelerate molecular diagnostics and imaging technologies to forecast disease susceptibilities in healthy populations and early diagnosis and personalized treatment of patients. This research evaluated CTMM's impact on scientific, translational, clinical, and economic dimensions. A pragmatic, operationally-defined process indicators approach was used. Data were gathered from CTMM administrations, through a CTMM-wide survey (n = 167) and group interviews. We found that the CTMM focused on disease areas with high human, clinical, and economic burden to society (i.e., oncology, cardiovascular, neurologic, infection, and immunity diseases). CTMM displayed a robust scientific impact that rests 15%–80% above international reference values regarding publication volume and impact. Technology translation to the clinic was accelerated, with >50% of projects progressing from pre-clinical development to clinical testing within 5 years. Furthermore, CTMM has generated nearly 1500 Full Time Equivalent (FTE) of translational R&D capacity. Its positive impact on translational, (future) clinical, and economic aspects is recognized across all surveyed stakeholders. As organizational innovation is increasingly considered critical to forge linkages between life sciences discoveries and innovation-in-society, lessons learned from this study may inform other institutions with similar objectives such as the Clinical and Translational Science Awards (CTSA) Program of the National Institutes of Health (NIH) in the United States. PMID:27195965

  18. Multi-Dimensional Impact of the Public-Private Center for Translational Molecular Medicine (CTMM) in the Netherlands: Understanding New 21(st) Century Institutional Designs to Support Innovation-in-Society.

    PubMed

    Steuten, Lotte M

    2016-05-01

    Knowledge translation is at the epicenter of 21st century life sciences and integrative biology. Several innovative institutional designs have been formulated to cultivate knowledge translation. One of these organizational innovations has been the Center for Translational Molecular Medicine (CTMM), a multi-million public-private partnership in the Netherlands. The CTMM aims to accelerate molecular diagnostics and imaging technologies to forecast disease susceptibilities in healthy populations and early diagnosis and personalized treatment of patients. This research evaluated CTMM's impact on scientific, translational, clinical, and economic dimensions. A pragmatic, operationally-defined process indicators approach was used. Data were gathered from CTMM administrations, through a CTMM-wide survey (n = 167) and group interviews. We found that the CTMM focused on disease areas with high human, clinical, and economic burden to society (i.e., oncology, cardiovascular, neurologic, infection, and immunity diseases). CTMM displayed a robust scientific impact that rests 15%-80% above international reference values regarding publication volume and impact. Technology translation to the clinic was accelerated, with >50% of projects progressing from pre-clinical development to clinical testing within 5 years. Furthermore, CTMM has generated nearly 1500 Full Time Equivalent (FTE) of translational R&D capacity. Its positive impact on translational, (future) clinical, and economic aspects is recognized across all surveyed stakeholders. As organizational innovation is increasingly considered critical to forge linkages between life sciences discoveries and innovation-in-society, lessons learned from this study may inform other institutions with similar objectives such as the Clinical and Translational Science Awards (CTSA) Program of the National Institutes of Health (NIH) in the United States.

  19. Time Resolved Resonance Raman Conference Royal Institution, London United Kingdom,

    DTIC Science & Technology

    1983-01-01

    of several polyenes were discussed in detail with the emphases on the detection and understanding of molecular transformation especially cis-trans...bacteriorhodopsin are closesly connected with the polyenes since the bacteriorhodopsin chro-ophose consists of a protonated shift base polyene . It is of interest to

  20. The first President of the Royal Society.

    PubMed

    Fara, Patricia

    2003-12-01

    Few people know the name of the Royal Society's first President, even though he features prominently in Thomas Sprat's famous allegorical frontispiece. In promotional images, his individual identity is irrelevant for proclaiming the Society's allegiance to Francis Bacon and commitment to experimental investigation. By contrast, William Brouncker's name does appear on Peter Lely's large portrait, which hung at the Royal Society. Brouncker was a gifted mathematician as well as a conscientious administrator, and Lely's portrait reproduces the diagram of one of his innovative algebraic proofs.

  1. [The intervention of the Royal College of Medicine in Nancy in the regulation of pharmaceutical activity].

    PubMed

    Labrude, Pierre

    2011-01-01

    Created in 1752 the Royal College of Medicine in Nancy constituted an institution with extended powers, particularly in sanitary policy and pharmaceutical activity. After explaining the rules of the College, the paper describes with examples its participation to the examinations of pharmacy pupils and their sustaining of "Conclusions de pharmacie et de chymie", to the delivery of drugs and to the fight against charlatanry and prohibited activity of pharmacy. From its creating to its disparition in 1793 by order of the government, the Royal College of Medicine worked remarkably, and the rules worked up during the forty years of its life appear to be of a great modernity.

  2. [Royal jelly: component efficiency, analysis, and standardisation].

    PubMed

    Oršolić, Nada

    2013-09-01

    Royal jelly is a viscous substance secreted by the hypopharyngeal and mandibular glands of worker honeybees (Apis mellifera) that contains a considerable amount of proteins, free amino acids, lipids, vitamins, sugars, and bioactive substances such as 10-hydroxy-trans-2-decenoic acid, antibacterial protein, and 350-kDa protein. These properties make it an attractive ingredient in various types of healthy foods. This article brings a brief review of the molecular mechanisms involved in the development of certain disorders that can be remedied by royal jelly, based on a selection of in vivo and in vitro studies. It also describes current understanding of the mechanisms and beneficial effects by which royal jelly helps to combat aging-related complications. Royal jelly has been reported to exhibit beneficial physiological and pharmacological effects in mammals, including vasodilative and hypotensive activities, antihypercholesterolemic activity, and antitumor activity. As its composition varies significantly (for both fresh and dehydrated samples), the article brings a few recommendations for defining new quality standards.

  3. A suggestion for royal jelly specifications.

    PubMed

    Kanelis, Dimitrios; Tananaki, Chrysoula; Liolios, Vasilis; Dimou, Maria; Goras, Georgios; Rodopoulou, Maria Anna; Karazafiris, Emmanuel; Thrasyvoulou, Andreas

    2015-12-01

    This article proposes guidelines for quality standards of royal jelly. The proposals are based on two sets of data; the first from our study of the factors that may affect the royal jelly's chemical composition (protein and sugar supplementation of beehives) and the second on the analysis of a great number of samples from across Greece to establish natural variability of this product. We compared our findings with the adopted national limits, the proposals of the working group of the International Honey Commission (IHC), and the draft proposal of the International Organization of Standardization (ISO). The studied parameters included moisture, total proteins, sugars (fructose, glucose, sucrose, total sugars), and 10-hydroxy- 2-decenoic acid (10-HDA). Our results indicate that the limits for royal jelly in some countries should be amended and the proposals of the IHC and the ISO reviewed in view of recent data on variability. We believe that our proposals could be considered for setting global standards for royal jelly, as they incorporate national legislations, proposals of scientific groups, experimental data, and updated information.

  4. Margaret Cavendish and the Royal Society

    PubMed Central

    Wilkins, Emma

    2014-01-01

    It is often claimed that Margaret Cavendish was an anti-experimentalist who was deeply hostile to the activities of the early Royal Society—particularly in relation to Robert Hooke's experiments with microscopes. Some scholars have argued that her views were odd or even childish, while others have claimed that they were shaped by her gender-based status as a scientific ‘outsider’. In this paper I examine Cavendish's views in contemporary context, arguing that her relationship with the Royal Society was more nuanced than previous accounts have suggested. This contextualized approach reveals two points: first, that Cavendish's views were not isolated or odd when compared with those of her contemporaries, and second, that the early Royal Society was less intellectually homogeneous than is sometimes thought. I also show that, although hostile to some aspects of experimentalism, Cavendish nevertheless shared many of the Royal Society's ambitions for natural philosophy, especially in relation to its usefulness and the importance of plain language as a means to disseminate new ideas. PMID:25254278

  5. Royal Naval nursing: 'testing but worth it'.

    PubMed

    Moore, Alison

    2014-08-19

    Inga Kennedy is the most senior nurse in the Royal Navy. She enjoys the commitment and discipline required by a career in the armed forces and says the work offers great opportunities for nurses. Her career highlights have included checking that injured personnel in Afghanistan were receiving the best care possible.

  6. netherland hydrological modeling instrument

    NASA Astrophysics Data System (ADS)

    Hoogewoud, J. C.; de Lange, W. J.; Veldhuizen, A.; Prinsen, G.

    2012-04-01

    Netherlands Hydrological Modeling Instrument A decision support system for water basin management. J.C. Hoogewoud , W.J. de Lange ,A. Veldhuizen , G. Prinsen , The Netherlands Hydrological modeling Instrument (NHI) is the center point of a framework of models, to coherently model the hydrological system and the multitude of functions it supports. Dutch hydrological institutes Deltares, Alterra, Netherlands Environmental Assessment Agency, RWS Waterdienst, STOWA and Vewin are cooperating in enhancing the NHI for adequate decision support. The instrument is used by three different ministries involved in national water policy matters, for instance the WFD, drought management, manure policy and climate change issues. The basis of the modeling instrument is a state-of-the-art on-line coupling of the groundwater system (MODFLOW), the unsaturated zone (metaSWAP) and the surface water system (MOZART-DM). It brings together hydro(geo)logical processes from the column to the basin scale, ranging from 250x250m plots to the river Rhine and includes salt water flow. The NHI is validated with an eight year run (1998-2006) with dry and wet periods. For this run different parts of the hydrology have been compared with measurements. For instance, water demands in dry periods (e.g. for irrigation), discharges at outlets, groundwater levels and evaporation. A validation alone is not enough to get support from stakeholders. Involvement from stakeholders in the modeling process is needed. There fore to gain sufficient support and trust in the instrument on different (policy) levels a couple of actions have been taken: 1. a transparent evaluation of modeling-results has been set up 2. an extensive program is running to cooperate with regional waterboards and suppliers of drinking water in improving the NHI 3. sharing (hydrological) data via newly setup Modeling Database for local and national models 4. Enhancing the NHI with "local" information. The NHI is and has been used for many

  7. 1. Historic American Buildings Survey Royal Insurance Co. Booklet '75 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Royal Insurance Co. Booklet '75 Royal Years', 1928 PHOTO TAKEN 1850's - Sacramento Block, Historic View, Sacramento Street & Battery Street, San Francisco, San Francisco County, CA

  8. Going Dutch: Higher Education in the Netherlands

    ERIC Educational Resources Information Center

    Law, David

    2016-01-01

    This article outlines some of the policy issues currently faced by research-based universities in the Netherlands. The focus is on four leading universities (University of Amsterdam: UvA; Free University of Amsterdam: VU; Leiden University; and Delft University of Technology: TUD). The author visited these institutions as part of a Study Tour…

  9. Going Dutch: Higher Education in the Netherlands

    ERIC Educational Resources Information Center

    Law, David

    2016-01-01

    This article outlines some of the policy issues currently faced by research-based universities in the Netherlands. The focus is on four leading universities (University of Amsterdam: UvA; Free University of Amsterdam: VU; Leiden University; and Delft University of Technology: TUD). The author visited these institutions as part of a Study Tour…

  10. Case of anaphylaxis caused by ingestion of royal jelly.

    PubMed

    Katayama, Mirei; Aoki, Mikako; Kawana, Seiji

    2008-04-01

    Anaphylaxis is a severe form of allergic disease. Royal jelly is widely consumed in Japan, but a few cases of anaphylaxis caused by royal jelly have been reported. We encountered a 26-year-old Japanese woman who developed anaphylaxis after drinking a beverage of crude royal jelly including honey. She had a history of bronchial asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis and food allergy (abalone). Prick tests were performed with the beverage of crude royal jelly including honey and with two other beverages including honey. Only the crude royal jelly beverage showed a positive reaction. An oral challenge test with the crude royal jelly beverage was not performed, but a similar test with a beverage including honey caused no symptoms. A positive response to the beverage of crude royal jelly was not observed in normal volunteers. A positive diagnosis of anaphylaxis due to royal jelly was made based on the positive prick test, systemic clinical symptoms and the negative prick tests in healthy volunteers. Moreover, the patient had no symptoms when taking lemon and orange, which were present as essences in the crude royal jelly beverage, and also had no response to honey after anaphylaxis. Increased consumption of royal jelly in health food supplements may increase the incidence of royal jelly-related allergic reactions. Therefore, royal jelly should be considered as a causative allergen in food-induced anaphylaxis.

  11. Forest Resources of Isle Royale National Park 2010

    Treesearch

    Wilfred J. Previant; Linda M. Nagel; Scott A. Pugh; Christopher W. Woodall

    2012-01-01

    This publication provides a baseline overview of forest resources for Isle Royale National Park (Isle Royale) using data from the Forest Inventory and Analysis (FIA) Program of the U.S. Department of Agriculture, Forest Service. The availability of permanent FIA plots allows for the first-ever comparison of Isle Royale's forest conditions (2006-2010) to reserved...

  12. Henry Oldenburg - Shaping the Royal Society

    NASA Astrophysics Data System (ADS)

    Boas Hall, Marie

    2002-03-01

    Henry Oldenburg, born in 1619 in Bremen, Germany, first came to England as a diplomat on a mission to see Oliver Cromwell. He stayed on in England and in 1662 became the Secretary of the Royal Society, and its best known member to the entire learned world of his time. Through his extensive correspondence, now published, he disseminated the Society's ideals and methods at home and abroad. He fostered and encouraged the talents of many scientists later to be far more famous than he, including Newton, Flamsteed, Malpighi, and Leeuwenhoek with whom, as with many others, he developed real friendship. He founded and edited the Philosophical Transactions, the world's oldest scientific journal.His career sheds new light on the intellectual world of his time, especially its scientific aspects, and on the development of the Royal Society; his private life expands our knowledge of social mobility, the urban society, and the religious views of his time.

  13. Inca Royal Estates in the Sacred Valley

    NASA Astrophysics Data System (ADS)

    McKim Malville, J.

    The royal estates lying between Cusco and Machu Picchu illustrate the remarkable variety by which the sun was honored and worshipped in the Inca Empire. The terraced basins of Moray combine the sun at both solstices and, perhaps, the zenith sun, with flowing water and offerings to Pachamama. The complex astronomy at Urubamba involves the palace of Quespiwanka, horizon pillars, solstices, and mountain worship. Ollantaytambo contains horizontal shadow-casting gnomons with a major water shrine.

  14. Birds of Isle Royale in Lake Superior

    USGS Publications Warehouse

    Krefting, L.W.; Lee, F.B.; Shelton, P.C.; Gilbert, K.T.

    1966-01-01

    This report constitutes an annotated list of 197 species of birds reported from Isle Royale National Park, a 210-square-mile archipelago in northwestern Lake Superior including some 200 islets and rock outcrops. The island is 45 miles long and 8 miles wide at its widest point. Bird distribution and habitats are described, along with geography and vegetation; 62 species are known to have bred at least once, 26 are thought to be breeders, and the rest are migrants.

  15. [A tale of 2 cities. The dispute over the true origins of the Royal Society].

    PubMed

    Beeley, Philip

    2008-01-01

    When the Royal Society was founded in November 1660 it took scientific societies already existing in other European countries as its model. However, at a time when the new mathematical and experimental sciences were still generally without a secure institutional foundation there was also great interest in the new society on the part of scientists and scholars abroad. Soon visitors such as Christiaan Huygens and Balthazar de Monconys were able to report positively on its practical orientation, while among others Johannes Hevelius and Philipp Jacob Sachs von Lewenhaimb in letters to the founder member John Wallis and to the secretary Henry Oldenburg requested more information on its origins and statutes. Meanwhile, in England the Royal Society found itself the object of vociferous criticism, especially from the universities, which saw their own role as centres of learning increasingly compromised by the existence of an institution dedicated to the promotion of modern science. The Royal Society responded to this interest from abroad and criticism at home by commissioning an official history written by Thomas Sprat, a man with a university as well as a literary background. However, despite the author's good credentials, the History of the Royal Society presents a one-sided account of the institution, mainly from the perspective of the circle around John Wilkins to which Sprat had belonged. According to their point of view the Royal Society arose from meetings which Wilkins had organized at Wadham College in Oxford in the early 1650s. For members of the old guard, such as Wallis and William Brouncker, the origins of the Royal Society were, however, not in Oxford but rather in London, where meetings involving a significant number of members of the future institution had taken place already in the mid-1640s. This was not simply a question of historical accuracy, but also of the way in which the Royal Society conceived itself: while the circle around Wilkins was in

  16. 76 FR 80433 - In the Matter of Royal Oak Capital Management, LLC, 6173 Bellevue Road, Royal Oak, MD 21662...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... of 1940 Release No. 3340] In the Matter of Royal Oak Capital Management, LLC, 6173 Bellevue Road, Royal Oak, MD 21662; Notice of Intention To Cancel Registration Pursuant to Section 203(H) of the... Advisers Act of 1940 (the ``Act''), cancelling the registration of Royal Oak Capital Management, LLC...

  17. Biomass in the Netherlands

    SciTech Connect

    Kwant, K.W. Jr.; Smakman, G.J.J.; Nillesen, F.H.G.

    1995-11-01

    The energy production from waste and biomass is one of the most promising methods of exploiting renewable energy in the Netherlands. The position of Dutch industry can be improved by means of technological development. An action plan for energy from waste and biomass will be implemented to double the energy output from the present 26 PJ to 54 PJ in 2000. Actions focus on targeted Research and Development with industry and market introduction with the energy production and distribution sector. The government will impose an energy tax (20%) on electricity and natural gas for households. Being a densely populated country the biomass resources originate mainly from waste and residue streams, while as a condition for conversion processes strict environmental regulations have to be met. Landfill gas is widely extracted and converted into energy. Part of the organic fraction of MSW is source separated, digested and upgraded to natural gas quality, while the digestate is used as compost. New development are in the area of cocombustion of wastewood in coal fired power stations. The first plant is under construction. A major R&D programme is set up with industry and research institutes on gasification of residues and biomass. At laboratory and pilotplant scale gasification experiments will be carried out with the different available streams. The major effect will be devoted to blending streams and gas cleaning.

  18. Characterization of major allergens of royal jelly Apis mellifera.

    PubMed

    Rosmilah, M; Shahnaz, M; Patel, G; Lock, J; Rahman, D; Masita, A; Noormalin, A

    2008-12-01

    Royal jelly is widely consumed in the community and has perceived benefits ranging from promoting growth in children and improvement of general health status to enhancement of longevity for the elderly. However, royal jelly consumption has been linked to contact dermatitis, acute asthma, anaphylaxis and death. High prevalence of positive skin tests to royal jelly have been reported among atopic populations in countries with a high rate of royal jelly consumption. The present study is aimed to identify the major allergens of royal jelly. Royal jelly extract was separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE) and 2-dimensional electrophoresis (2-D). Immunoblotting of the SDS-PAGE and 2-D profiles were performed to identify the allergenic spots. Spots were then excised from the 2-D gel, digested with trypsin and analyzed by mass spectrometry. The SDS-PAGE of royal jelly extract revealed 18 bands between 10 to 167 kD. Western blot of the fractionated proteins detected 15 IgE-binding bands between 14 to 127 kD with seven major allergens of 32, 40, 42, 49, 55, 60 and 67 kD using serum from 53 subjects with royal jelly allergy. The 2-D gel fractionated the royal jelly proteins to more than 50 different protein spots. Out of these, 30 spots demonstrated specific IgE affinity to the sera tested. Eight spots of the major royal jelly allergens were selected for mass-spectrometry analysis. Digested tryptic peptides of the spots were compared to the amino acid sequence search in protein databases which identified the fragments of royal jelly homologus to major royal jelly protein 1 (MRJ1) and major royal jelly protein 2 (MRJ2). In conclusion, the major allergens of royal jelly are MRJ1 and MRJ2 in our patients' population.

  19. Royal jelly counteracts bucks' "summer infertility".

    PubMed

    Elnagar, Samar A

    2010-08-01

    Exposure of male rabbits to heat stress during summer adversely affects their fertility leading to major production losses. A total number of 24 male rabbits were randomly divided into four experimental groups exposed to temperatures ranging from a high of 32 degrees C to a low of 23 degrees C. Animals of the 2nd, 3rd and 4th group were individually orally given 200, 400, or 800 mg royal jelly (RJ)/kg body weight once a week to evaluate the ability of RJ feeding to counteract "summer infertility" in bucks and enhance their physiological status. Royal jelly treatments significantly boosted testosterone level to 133, 143 and 124% of basal, increased ejaculated volume by 36, 31 and 18%, increased seminal plasma fructose to 122, 124, and 111%, improved sperm motility by 15, 18 and 5%, increase sperm total output by 65, 63 and 35%, reduced abnormal sperm by 24, 24 and 15% and dead sperm by 27, 25 and 17% compared to the heat stressed control animals. Serum total protein, albumin and globulin increased while serum total lipids, cholesterol and triglycerides decreased with RJ treatments. Creatinine was reduced by 5, 13 and 8% and uric acid by 4, 7 and 4%, respectively for the three doses of RJ compared to control. Alkaline phosphatase has significantly increased to reach 114, 118, and 108% of heat stressed level with the three doses of RJ, indicating the occurrence of active bone deposition. Glucose level increased significantly to reach 105, 112, and 116% of heat stressed control and both calcium and phosphorus increased significantly with RJ treatments. It was concluded that royal jelly administration to heat stressed male rabbits can counteract their "summer infertility" and improve their physiological status.

  20. Rare royal families in honeybees, Apis mellifera

    NASA Astrophysics Data System (ADS)

    Moritz, Robin F. A.; Lattorff, H. Michael G.; Neumann, Peter; Kraus, F. Bernhard; Radloff, Sarah E.; Hepburn, H. Randall

    2005-10-01

    The queen is the dominant female in the honeybee colony, Apis mellifera, and controls reproduction. Queen larvae are selected by the workers and are fed a special diet (royal jelly), which determines caste. Because queens mate with many males a large number of subfamilies coexist in the colony. As a consequence, there is a considerable potential for conflict among the subfamilies over queen rearing. Here we show that honeybee queens are not reared at random but are preferentially reared from rare “royal” subfamilies, which have extremely low frequencies in the colony's worker force but a high frequency in the queens reared.

  1. Oral allergy syndrome in a child provoked by royal jelly.

    PubMed

    Paola, Fantini; Pantalea, Delle Donne; Gianfranco, Calogiuri; Antonio, Ferrannini; Angelo, Vacca; Eustachio, Nettis; Elisabetta, Di Leo

    2014-01-01

    Royal jelly has been demonstrated to have several physiological activities. However, in the literature, different reactions induced by royal jelly are reported. We describe a case of seven-year-old child that was referred to our observation for two episodes of oral allergy syndrome (OAS) that appeared ten minutes after ingestion of royal jelly. Skin prick test with standard panel of inhalant and food allergens, a prick-to-prick test using the royal jelly's extract responsible for patient's reactions, and royal jelly patch test with extemporaneous preparation were performed. The specific IgE by ImmunoCAP System method versus Hymenoptera venom, inhalant allergens, food allergens, and lipid transfer proteins was dosed. According to the positive reactions to royal jelly both by prick-by-prick test and by a first reading patch test, royal jelly immediate hypersensitivity was diagnosed. According to the positive response for almond in both in vivo and in vitro tests we can think of the royal jelly contamination with almond pollen as possible cause of patient's reaction. Moreover, from the results of specific IgE titers versus Compositae pollens, we have argued the possibility that this case of royal jelly allergy could be explained also by the mechanism of cross-reaction with Compositae pollens.

  2. Oral Allergy Syndrome in a Child Provoked by Royal Jelly

    PubMed Central

    Paola, Fantini; Pantalea, Delle Donne; Gianfranco, Calogiuri; Antonio, Ferrannini; Angelo, Vacca; Eustachio, Nettis; Elisabetta, Di Leo

    2014-01-01

    Royal jelly has been demonstrated to have several physiological activities. However, in the literature, different reactions induced by royal jelly are reported. We describe a case of seven-year-old child that was referred to our observation for two episodes of oral allergy syndrome (OAS) that appeared ten minutes after ingestion of royal jelly. Skin prick test with standard panel of inhalant and food allergens, a prick-to-prick test using the royal jelly's extract responsible for patient's reactions, and royal jelly patch test with extemporaneous preparation were performed. The specific IgE by ImmunoCAP System method versus Hymenoptera venom, inhalant allergens, food allergens, and lipid transfer proteins was dosed. According to the positive reactions to royal jelly both by prick-by-prick test and by a first reading patch test, royal jelly immediate hypersensitivity was diagnosed. According to the positive response for almond in both in vivo and in vitro tests we can think of the royal jelly contamination with almond pollen as possible cause of patient's reaction. Moreover, from the results of specific IgE titers versus Compositae pollens, we have argued the possibility that this case of royal jelly allergy could be explained also by the mechanism of cross-reaction with Compositae pollens. PMID:24799914

  3. Friend Not Foe: The Role of Curriculum Committee in Supporting the Development of Curriculum at Royal Roads University

    ERIC Educational Resources Information Center

    Young, Michael G.

    2015-01-01

    Curriculum Committee at Royal Roads University (RRU) is mandated with ensuring that program and course curricula are of sufficient high academic integrity, consistent with other academic institutions, delivered in a manner consistent with program outcomes, and align with the recently adopted Learning and Teaching Model. Yet, the apparent…

  4. Quantification of major royal jelly protein 1 in fresh royal jelly by indirect enzyme-linked immunosorbent assay.

    PubMed

    Yamaguchi, Kikuji; He, Shaoyu; Li, Zhengyue; Murata, Kiyoshi; Hitomi, Nobuyuki; Mozumi, Manaho; Ariga, Risa; Enomoto, Toshiki

    2013-01-01

    Rabbit polyclonal antibody produced by a major royal jelly protein 1 (MRJP1) specific peptide reacted only with a MRJP1. Indirect ELISA with the antibody revealed a MRJP1 level of 4.12-4.67 g/100 g in different company's royal jelly, which almost agreed with that of a hexametric form of MRJP1 (apisin) measured by high performance liquid chromatography. These results suggest that MRJP1 exists mainly as apisin in royal jelly.

  5. An extended monitoring network for the volcanoes of St. Eustatius and Saba, the Caribbean Netherlands.

    NASA Astrophysics Data System (ADS)

    de Zeeuw-van Dalfsen, Elske; Sleeman, Reinoud; Evers, Läslo G.

    2017-04-01

    The volcanoes of the Quill (St. Eustatius) and Mt. Scenery (Saba) are part of the Lesser Antilles volcanic island arc in the West Indies, which hosts seventeen active volcanoes. The last eruptive activity at the Quill occurred 1600-1800 years ago but Mt. Scenery erupted as recent as in 1640. The existence of heated groundwater at St. Eustatius and hot springs at Saba indicate that both the Quill and Mt. Scenery are active, but quiet, rather than extinct. Volcanic hazard is therefore present and monitoring of these volcanoes of utmost importance. Especially considering the fact that Soufrière Hills volcano, at the neighbouring island of Montserrat and of comparable nature to Mt. Scenery, started to erupt in 1995 after 450 years of quietness. Currently, a network of four broadband seismometers is operational at each island. Seismic data are transmitted in real-time to the Royal Netherlands Meteorological Institute (KNMI), where they are (automatically) analysed. We plan to extend this monitoring effort by adding integrated geodetic observations (campaign and continuous GPS, InSAR) and temperature measurements of the hot springs. Furthermore we intend to improve our understanding of the terrain and surface geology by thorough analysis of a TanDEM-X DEM. An improved geophysical characterization of the islands is of great importance both for the population and local governments. These combined efforts will greatly improve the chance to observe the onset and follow the evolution of a future volcanic crisis.

  6. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  7. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  8. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  9. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  10. 36 CFR 7.38 - Isle Royale National Park.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Isle Royale National Park. 7.38 Section 7.38 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.38 Isle Royale National Park. (a) Aircraft...

  11. 1. VIEW SHOWING FOUNDATIONS OF HOISTING WORKS, ROYAL MINE, 1988, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW SHOWING FOUNDATIONS OF HOISTING WORKS, ROYAL MINE, 1988, LOOKING SOUTHEAST. GLORY HOLE DROPS OFF TO LEFT, AND EXCAVATED TRENCH FOR THE 1920s SURFACE TRAM IN RIGHT FOREGROUND - Royal Consolidated Gold Mine & Mills, Hoisting Work, 4.0 Air Miles Northwest of Copperopolis, Copperopolis, Calaveras County, CA

  12. The case for watchful waiting with Isle Royale's wolf population

    USGS Publications Warehouse

    Mech, L. David

    2013-01-01

    In "Should Isle Royale Wolves be Reintroduced? A Case Study on Wilderness Management in a Changing World," Vucetich et al. concluded with the hope that their analysis “motivates broader discussion that deepens understanding of the specifics on Isle Royale and the underlying principles” (2012: 137). This article represents an attempt to continue that discussion.

  13. [The Royal Protomedicato Tribunal and the surgical profession in eighteenth century Spain].

    PubMed

    Astrain Gallart, M

    1996-01-01

    Different approaches to the study of the Royal Protomedicato have not been entirely successful in defining its roles and connections with other organizations that controlled the practice of health professions during the Enlightenment. The loss of manuscript sources relating to the institution has been an almost insurmountable obstacle. In this study we examine the difficult relationships between the Protomedicato and the elite members of the Corps of Military Surgeons who made possible the implementation of a new model of training in surgery in Spain. The establishment of teaching imparted by the new colleges of surgery, together with the restrictions on access to the profession, drove a wedge into the traditional forms of control previously exerted by physicians through the Royal Protomedicato. These changes led to reforms in the tribunal.

  14. Genotype analysis identifies the cause of the "royal disease".

    PubMed

    Rogaev, Evgeny I; Grigorenko, Anastasia P; Faskhutdinova, Gulnaz; Kittler, Ellen L W; Moliaka, Yuri K

    2009-11-06

    The "royal disease," a blood disorder transmitted from Queen Victoria to European royal families, is a striking example of X-linked recessive inheritance. Although the disease is widely recognized to be a form of the blood clotting disorder hemophilia, its molecular basis has never been identified, and the royal disease is now likely extinct. We identified the likely disease-causing mutation by applying genomic methodologies (multiplex target amplification and massively parallel sequencing) to historical specimens from the Romanov branch of the royal family. The mutation occurs in F9, a gene on the X chromosome that encodes blood coagulation factor IX, and is predicted to alter RNA splicing and to lead to production of a truncated form of factor IX. Thus, the royal disease is the severe form of hemophilia, also known as hemophilia B or Christmas disease.

  15. Psychotraumatology in the Netherlands

    PubMed Central

    Vermetten, Eric; Olff, Miranda

    2013-01-01

    The contribution to psychotrauma literature from Dutch authors has a long tradition. The relatively high lifetime prevalence of trauma and posttraumatic stress disorder (PTSD) is not unique for the Netherlands and does not fully explain the interest in trauma and its consequences. In this overview of psychotraumatology in the Netherlands, we will discuss some of the key events and processes that contribute to the current interest. We outlined the historical basis and development of the field in the Netherlands, including the impact of World War II, the effects of major man-made or natural disasters, engagement in military conflicts, as well as smaller scale traumatic events like sexual abuse and traffic accidents. The liberal and open culture may have reduced stigma to trauma, while other sociocultural aspects may have contributed to increased prevalence. Finally, we describe Dutch psychotraumatology today and how history and culture have shaped the current scientific basis. PMID:23671764

  16. [Academies Institute Andalucia].

    PubMed

    Piédrola Angulo, Gonzalo

    2012-01-01

    Academies Institute of Andalusia is the only corporation in the State grouping twenty seven Spanish Academies and Royal Academies of an autonomous region, with a total of 760 Academicians. This paper sets out as conceived, their roles and relationships with other national corporations, as well as the primary mission to maintain and strengthen fraternal relations, culture, research and collaboration between the Andalusian Academy, showing academic representation whole of them.

  17. GUIDE TO NETHERLANDIC STUDIES, BIBLIOGRAPHY.

    ERIC Educational Resources Information Center

    LAGERWEY, WALTER

    THIS BIBLIOGRAPHY OF NETHERLANDIC STUDIES IS A REVISED AND AUGMENTED EDITION OF A REFERENCE GUIDE PREPARED IN 1961. THE TERM "NETHERLANDIC" IS USED TO REFER TO THE GEOGRAPHICAL AREA WHERE THE DUTCH (FLEMISH) LANGUAGE IS SPOKEN. THE BIBLIOGRAPHY OFFERS INFORMATION ON PRINCIPAL STUDIES OF THE NETHERLANDIC PEOPLES' LANGUAGE, LITERATURE,…

  18. Comparing distinct ground-based lightning location networks covering the Netherlands

    NASA Astrophysics Data System (ADS)

    de Vos, Lotte; Leijnse, Hidde; Schmeits, Maurice; Beekhuis, Hans; Poelman, Dieter; Evers, Läslo; Smets, Pieter

    2015-04-01

    Lightning can be detected using a ground-based sensor network. The Royal Netherlands Meteorological Institute (KNMI) monitors lightning activity in the Netherlands with the so-called FLITS-system; a network combining SAFIR-type sensors. This makes use of Very High Frequency (VHF) as well as Low Frequency (LF) sensors. KNMI has recently decided to replace FLITS by data from a sub-continental network operated by Météorage which makes use of LF sensors only (KNMI Lightning Detection Network, or KLDN). KLDN is compared to the FLITS system, as well as Met Office's long-range Arrival Time Difference (ATDnet), which measures Very Low Frequency (VLF). Special focus lies on the ability to detect Cloud to Ground (CG) and Cloud to Cloud (CC) lightning in the Netherlands. Relative detection efficiency of individual flashes and lightning activity in a more general sense are calculated over a period of almost 5 years. Additionally, the detection efficiency of each system is compared to a ground-truth that is constructed from flashes that are detected by both of the other datasets. Finally, infrasound data is used as a fourth lightning data source for several case studies. Relative performance is found to vary strongly with location and time. As expected, it is found that FLITS detects significantly more CC lightning (because of the strong aptitude of VHF antennas to detect CC), though KLDN and ATDnet detect more CG lightning. We analyze statistics computed over the entire 5-year period, where we look at CG as well as total lightning (CC and CG combined). Statistics that are considered are the Probability of Detection (POD) and the so-called Lightning Activity Detection (LAD). POD is defined as the percentage of reference flashes the system detects compared to the total detections in the reference. LAD is defined as the fraction of system recordings of one or more flashes in predefined area boxes over a certain time period given the fact that the reference detects at least one

  19. NCI at Frederick Receives a Royal Visit | Poster

    Cancer.gov

    The Center for Cancer Research (CCR) and NCI at Frederick recently had the honor of hosting Professor Dr. Her Royal Highness Princess Chulabhorn Mahidol of Thailand. Her Royal Highness has a special interest in scientific research related to the use of natural products for treating disease. The purpose of her visit was to discuss the work on natural products being undertaken at NCI at Frederick. Her Royal Highness attended talks by researchers from both the Molecular Targets Laboratory (MTL), CCR, and the Natural Products Branch (NPB), Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD).

  20. NCI at Frederick Receives a Royal Visit | Poster

    Cancer.gov

    The Center for Cancer Research (CCR) and NCI at Frederick recently had the honor of hosting Professor Dr. Her Royal Highness Princess Chulabhorn Mahidol of Thailand. Her Royal Highness has a special interest in scientific research related to the use of natural products for treating disease. The purpose of her visit was to discuss the work on natural products being undertaken at NCI at Frederick. Her Royal Highness attended talks by researchers from both the Molecular Targets Laboratory (MTL), CCR, and the Natural Products Branch (NPB), Developmental Therapeutics Program (DTP), Division of Cancer Treatment and Diagnosis (DCTD).

  1. Geoengineering the climate - the Royal Society study

    NASA Astrophysics Data System (ADS)

    Parker, Andrew

    2010-05-01

    The majority of the climate change we are experiencing now is very likely caused by an increase in greenhouse gases due to human activities, including burning fossil fuels, agriculture and deforestation. There is now widespread belief that a global warming of greater than 2 degrees C above pre-industrial levels would be dangerous and should therefore be avoided. However, despite growing concerns over climate change, global CO2 emissions have continued to climb. This has led some to suggest more radical "geoengineering" alternatives to conventional mitigation via reductions in CO2 emissions. Geoengineering is the deliberate intervention in the climate system to counteract man-made global warming. There are two main classes of geoengineering: direct carbon dioxide removal from the atmosphere, and solar radiation management, which aims to cool the planet by reflecting more sunlight out to space. This presentation will summarise the findings of a recent review of geoengineering carried-out by the UK Royal Society, discussing the climate effects, costs, risks, and research and governance needs for each approach. Key findings include: • Geoengineering is not a magic bullet and not an alternative to emissions reductions. • Cutting global greenhouse gas emissions must remain our highest priority... • ... but this is proving to be difficult, and some forms of geoengineering may be useful to support it • Some carbon dioxide removal and solar radiation management techniques are very likely to be technically possible • However, there are major uncertainties and potential risks concerning effectiveness, costs and social & environmental impacts • Much more research is needed, as well public engagement and a system of regulation (for both deployment and for some R&D). • The acceptability of geoengineering will be determined as much by social, legal and political issues as by scientific and technical factors

  2. Media in the Netherlands.

    ERIC Educational Resources Information Center

    Klaver, Franca

    This 2-part report summarizes Dutch policy on mass media and reviews the status of cable television in the Netherlands. The first part defines the underlying principles of a national policy on mass media in relation to the press, commercial and educational television broadcasting, radio, cable television, and media research. Parliamentary debate…

  3. Media in the Netherlands.

    ERIC Educational Resources Information Center

    Klaver, Franca

    This 2-part report summarizes Dutch policy on mass media and reviews the status of cable television in the Netherlands. The first part defines the underlying principles of a national policy on mass media in relation to the press, commercial and educational television broadcasting, radio, cable television, and media research. Parliamentary debate…

  4. VIEW OF DATE DRIVE, SHOWING ROYAL PALMS ALONG THE STREET. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF DATE DRIVE, SHOWING ROYAL PALMS ALONG THE STREET. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

  5. 2. Photocopy of a measured drawing (original delineated the Royal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of a measured drawing (original delineated the Royal Danish Academy of Fine Arts (Kunstakademiets), Copenhagen, Denmark, 1961) FRONT (KING STREET) ELEVATION AND PLANS OF FIRST AND SECOND FLOORS - Kongensgade 58 (House), 58 King Street, Christiansted, St. Croix, VI

  6. IFLA General Conference, 1985. Collection and Services Division. Section: Interlending and Document Delivery. The Online System of Union Catalogues and Interlibrary Loan ('NCC/IBL') in the Netherlands.

    ERIC Educational Resources Information Center

    Willemsen, Arie W.

    This paper describes the interlending system in the Netherlands and examines the country's union catalogs, the main instrument in the interlending procedure. An overview of the integrated interlending system is provided; the union catalogs of the Royal Library in The Hague, the Technical University Library at Delft, and the library of the…

  7. The Observers Observed: Charles Dickens at the Royal Observatory, Greenwich, in 1850

    NASA Astrophysics Data System (ADS)

    Chapman, A.

    2005-12-01

    In 1850 the magazine Household Words, which Charles Dickens edited, published three articles describing the instruments and workings of the Royal Observatory, Greenwich. These 'popular' articles are invaluable primary sources for the historian of astronomy. They convey some of the Victorian public's fascination with an Institution believed by some to be a lighthouse for night-time shipping on the river Thames; by others, a national repository of 'divining rods' and 'magic mirrors'. Dickens was clearly impressed by the pragmatic usefulness of the Observatory to a commercial and maritime nation, and by seemingly magical, self-acting and recording instruments whereby the wind wrote its own 'Aeolian Autobiography'.

  8. Electron spin resonance spectral analysis of irradiated royal jelly.

    PubMed

    Yamaoki, Rumi; Kimura, Shojiro; Ohta, Masatoshi

    2014-01-15

    The analysis of unpaired electron components in royal jelly was carried out using electron spin resonance (ESR) with the aim to develop a detection method for irradiated royal jelly. The ESR spectrum of royal jelly had natural signals derived from transition metals, including Fe(3+) and Cu(2+), and a signal line near g=2.00. After irradiation, a new splitting asymmetric spectrum with overall spectrum width ca. 10mT at g=2.004 was observed. The intensities of the signals at g=2.004 increased in proportion to the absorbed dose in samples under different storage conditions: fresh frozen royal jelly and dried royal jelly powder at room temperature. The signal intensity of the fresh frozen sample was stable after irradiation. One year after 10kGy irradiation of dried powder, the signal intensity was sevenfold greater than before irradiation, although the intensity continued to steadily decrease with time. This stable radiation-induced radical component was derived from the poorly soluble constituent of royal jelly.

  9. Euthanasia in The Netherlands.

    PubMed Central

    van der Wal, G.; Dillmann, R. J.

    1994-01-01

    The practice of euthanasia in the Netherlands is often used as an argument in debates outside the Netherlands--hence a clear description of the Dutch situation is important. This article summarises recent data and discusses conceptual issues and relevant characteristics of the system of health care. Special emphasis is put on regulation, including relevant data on notification and prosecution. Besides the practice of euthanasia the Dutch are confronted with the gaps in reporting of cases to the public prosecutor and the existence of cases of ending a life without an explicit request. Nevertheless, the "Dutch experiment" need not inevitably lead down the slippery slope because of the visibility and openness of this part of medical practice. This will lead to increased awareness, more safeguards, and improvement of medical decisions concerning the end of life. PMID:8019226

  10. Euthanasia in The Netherlands.

    PubMed

    van der Wal, G; Dillmann, R J

    1994-05-21

    The practice of euthanasia in the Netherlands is often used as an argument in debates outside the Netherlands--hence a clear description of the Dutch situation is important. This article summarises recent data and discusses conceptual issues and relevant characteristics of the system of health care. Special emphasis is put on regulation, including relevant data on notification and prosecution. Besides the practice of euthanasia the Dutch are confronted with the gaps in reporting of cases to the public prosecutor and the existence of cases of ending a life without an explicit request. Nevertheless, the "Dutch experiment" need not inevitably lead down the slippery slope because of the visibility and openness of this part of medical practice. This will lead to increased awareness, more safeguards, and improvement of medical decisions concerning the end of life.

  11. The development of healthy tennis clubs in the Netherlands.

    PubMed

    Pluim, Babette M; Earland, Jane; Pluim, Nicole E

    2014-06-01

    To explore the factors that facilitate or hinder the development of healthy tennis clubs in the Netherlands and to identify suitable interventions that would help clubs to reach 'healthy club' status. A maximum variation, purposive sampling strategy was used to identify and recruit board members (n=16) from 10 Dutch tennis clubs. Data were collected using in-depth interviews based on an interview guide. The interviews explored what steps the clubs had taken to create a healthy tennis club, and what the respondents perceived to be the barriers to reaching healthy club status. The data were analysed using thematic content analysis. An ecological model was used to frame the interpretation of the themes and guide the development of the interventions. Four emerging themes were identified: provision of healthy foods, injury prevention and health services, social health and safety around the club. The main facilitators were found to be support from club management, having appropriate policies in place and having appointed officers. The main barriers were identified as a lack of policy templates, inadequate knowledge of coaches on injury prevention and injury management and fragmented access to relevant information. Guided by an ecological model, this study demonstrates the many factors that influence tennis clubs and the individual members of a healthy tennis club. Using this model, a multilevel intervention framework has been created that could be used by the Royal Netherlands Lawn Tennis Association to increase the number of healthy tennis clubs in the Netherlands.

  12. Study in the Netherlands: Small Countries Have To Be Smarter.

    ERIC Educational Resources Information Center

    Netherlands Organisation for International Cooperation in Higher Education, The Hague.

    This booklet describes opportunities for higher education study in the Netherlands along with information, addresses, and practical tips for foreign students who are considering taking a course or earning a degree at a Dutch institution of higher education. Six sections cover: (1) the investment of study abroad, (2) background on contemporary…

  13. Saving for Learning in the Netherlands. Research Report.

    ERIC Educational Resources Information Center

    Biggar, Sharon

    The Netherlands has been characterized by highly differentiated secondary education, with separate practical, vocational, secondary, and pre-university institutions. Over time, these have converged somewhat. Well-thought-out vocational and adult programs emphasize providing skills needed in the workplace. At least part-time education is compulsory…

  14. Sociology of Education in the Netherlands: Situations, Developments, Debates.

    ERIC Educational Resources Information Center

    Wesselingh, Anton

    1982-01-01

    Describes the origins and sources of the sociology of education in the Netherlands, the institutional context in which it is embedded, and the fields of research and theory that it covers. The realization of expected trends of the field is examined. (AM)

  15. The Netherlands: country profile.

    PubMed

    1985-12-01

    This discussion of the Netherlands covers the country's cities and regions, population growth, households and families, housing, contruction, and spatial planning; ethnicity and religion; education; labor force and income; consumption; and transport and communications. As a small and mineral poor nation with a seafaring tradition, the Netherlands survives on foreign trade. In 1983, total export earnings amounted to nearly 62% of the entire national income. Over 72% of Dutch exports go to other member countries of the European Economic Community (EEC), but imports are more diversified, with 47% originating outside the EEC. Since 1848, the Netherlands has been a constitutional monarchy with a parliamentary form of government. As such, it is one of the most stable democracies in the world. The main administrative units are the 11 provinces, of which Noord-Holland and Zuid-Holland are the most populous and economically most important. Amsterdam remains the commercial center of the country, but its role as the principal port city has been taken over by Rotterdam. No community has more than 700,000 inhabitants, but the country as a whole is highly urbanized because of the large numbers of medium-sized cities. In 1983 the population of the Netherlands totaled 14.34 million, compared to 5.10 million at the turn of the century. In 1965, the total fertility rate was 3.0. The death rate has virtually stabilized at 8/1000. The Dutch life expectancy stands at 72.7 years for men and 79.4 for women (1983). Natural increase has already dropped to 0.4% a year. Apart from the slight impact of net immigration, the positive growth rate reflects the large proportion (53%) of the population in its reproductive years. Mean household sizes in the 11 provinces vary from 2.5 in Noord-Holland (in 1981) to nearly 3 in Overijssel and Noord-Brabant, whereas the proportion of 1 person households ranges from 16% in Drenthe and 17% in the somewhat traditionalist southern provinces of Limburg and

  16. A l'écoute de nos instituts scientifiques.

    NASA Astrophysics Data System (ADS)

    Henrard, J.; Arnould, M.; Demaret, J.; Noels, A.; Vercheval, J.; Crommelynck, D.; Melchior, P.

    The authors give some important events which occurred during the last academic year 1981-1982 in six scientific institutes in Belgium (Groupe de mécanique céleste, Département de Mathématique, Facultés Universitaires de Namur; Institut d'Astronomie, d'Astrophysique et de Géophysique, Université Libre de Bruxelles; Institut d'Astrophysique, Université de Liège; l'Institut d'Aéronomie Spatiale de Belgique; Institut Royal Météorologique de Belgique; Observatoire Royal de Belgique).

  17. Royal jelly attenuates azathioprine induced toxicity in rats.

    PubMed

    Ahmed, Walaa M S; Khalaf, A A; Moselhy, Walaa A; Safwat, Ghada M

    2014-01-01

    In the present study, we investigated the potential protective effects of royal jelly against azathioprine-induced toxicity in rat. Intraperitoneal administration of azathioprine (50 mg/kgB.W.) induced a significant decrease in RBCs count, Hb concentration, PCV%, WBCs count, differential count and platelet count, hepatic antioxidant enzymes (reduced glutathione and glutathione s-transferase) and increase of serum transaminases (alanine aminotransferase and aspartate aminotransferase enzymes) activities, alkaline phosphatase and malondialdehyde formation. Azathioprine induced hepatotoxicity was reflected by marked pathological changes in the liver. Oral administration of royal jelly (200 mg/kgB.W.) was efficient in counteracting azathioprine toxicity whereas it altered the anemic condition, leucopenia and thrombocytopenia induced by azathioprine. Furthermore, royal jelly exerted significant protection against liver damage induced by azathioprine through reduction of the elevated activities of serum hepatic enzymes. Moreover, royal jelly blocked azathioprine-induced lipid peroxidation through decreasing the malondialdehyde formation. In conclusion, royal jelly possesses a capability to attenuate azathioprine-induced toxicity.

  18. Conservation genetics of the endangered Isle Royale gray wolf

    USGS Publications Warehouse

    Wayne, R.K.; Lehman, N.; Girman, D.; Gogan, P.J.P.; Gilbert, D.A.; Hansen, K.; Peterson, R.O.; Seal, U.S.; Eisenhawer, A.; Mech, L.D.; Krumenaker, R.J.

    1991-01-01

    The small group of wolves on Isle Royale has been studied for over three decades as a model of the relationship between large carnivores and their prey. During the last ten years the population declined from 50 individuals to as few as 12 individuals. The causes of this decline may be food shortages, disease, or reduced genetic variability. We address the issues of genetic variability and relationships of Isle Royale wolves using allozyme electrophoresis, mtDNA restriction-site analysis, and multilocus hypervariable minisatellite DNA analysis (genetic fingerprinting). Our results indicate that approximately 50% of the allozyme heterozygosity has been lost in the island population, a decline similar to that expected if no immigration had occurred from the mainland. The genetic fingerprinting data indicate that the seven sampled Isle Royale wolves are as similar as captive populations of siblings. Surprisingly, the Isle Royale wolves have an mtDNA genotype that is very rare on the mainland, being found in only one of 144 mainland wolves. This suggests that the remaining Isle Royale wolves are probably derived from a single female founder.

  19. Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography.

    PubMed

    Genç, M; Aslan, A

    1999-04-16

    In this research, several royal jellies and commercial products containing royal jelly were analysed for their trans-10-hydroxy-2-decenoic acid (10-HDA) content by using a column liquid chromatography technique. Ten samples claimed to be pure royal jelly, containing 10-HDA between 0.75 and 2.54%. Seven samples claimed to contain royal jelly as an ingredient which ranged from non-detectable to 0.054%. The technique was found to be rapid with high recovery.

  20. Octanoic acid confers to royal jelly varroa-repellent properties

    NASA Astrophysics Data System (ADS)

    Nazzi, Francesco; Bortolomeazzi, Renzo; Della Vedova, Giorgio; Del Piccolo, Fabio; Annoscia, Desiderato; Milani, Norberto

    2009-02-01

    The mite Varroa destructor Anderson & Trueman is a parasite of the honeybee Apis mellifera L. and represents a major threat for apiculture in the Western world. Reproduction takes place only inside bee brood cells that are invaded just before sealing; drone cells are preferred over worker cells, whereas queen cells are not normally invaded. Lower incidence of mites in queen cells is at least partly due to the deterrent activity of royal jelly. In this study, the repellent properties of royal jelly were investigated using a lab bioassay. Chemical analysis showed that octanoic acid is a major volatile component of royal jelly; by contrast, the concentration is much lower in drone and worker larval food. Bioassays, carried out under lab conditions, demonstrated that octanoic acid is repellent to the mite. Field studies in bee colonies confirmed that the compound may interfere with the process of cell invasion by the mite.

  1. [The Protomedicato Tribunal and the royal physicians (1665-1724)].

    PubMed

    Pardo Tomás, J; Martínez Vidal, A

    1996-01-01

    This article tries to reconstruct the composition of the Board of Royal Physicians during the reign of Charles II (1665-1799) and the first part of the reign of Philip V (1700-1724), a crucial period in the introduction of modern science and medicine in the Spanish Kingdoms. Their personal records, to be found in the Archivo General de Palacio in Madrid, have been exhaustively consulted. Some of these royal physicians formed part of the Castilian Tribunal del Protomedicato, by means of which the Board of Royal Physicians was selected, promoted and controlled. The Protomedicato was an important battlefield in the conflict between traditional and modern medicine, in which Italian physicians played a decisive role.

  2. Unlocking the Royal Geographical Society Archives: The Experiences of a Fellow of the Society as a Teacher and as a Researcher

    ERIC Educational Resources Information Center

    Segell, Glen M.

    2005-01-01

    Purpose: To detail a user's experiences of the digital archive project of the Royal Geographical Society (with the Institute of British Geographers) (RGS-IBG). The "Unlocking the Archives" project has five facets: construction and conservation at its London archives; an online catalogue of its collections; digitisation of images and…

  3. Wolves, moose, and tree rings on isle royale.

    PubMed

    McLaren, B E; Peterson, R O

    1994-12-02

    Investigation of tree growth in Isle Royale National Park in Michigan revealed the influence of herbivores and carnivores on plants in an intimately linked food chain. Plant growth rates were regulated by cycles in animal density and responded to annual changes in primary productivity only when released from herbivory by wolf predation. Isle Royale's dendrochronology complements a rich literature on food chain control in aquatic systems, which often supports a trophic cascade model. This study provides evidence of top-down control in a forested ecosystem.

  4. Westland, The Netherlands

    NASA Image and Video Library

    2017-09-18

    Westland in the Netherlands is the greenhouse capital of the world. It is the number two exporter of food as measured by value, second only to the United States. This is accomplished inside of almost 100 square kilometers of greenhouses. Tomato production, for example is 1 million tons per year, grown on only 18 square kilometers of area, making it number one globally in efficiency. The image was acquired June 12, 2014, covers an area of 13.5 by 18.4 kilometers, and is located at 52 degrees north, 4.3 degrees east. https://photojournal.jpl.nasa.gov/catalog/PIA21986

  5. Technical Writing in the Netherlands.

    ERIC Educational Resources Information Center

    de Vet, Dominique M. W.

    1996-01-01

    Discusses the technical writing profession in the Netherlands. Bases the discussion on two studies--one directed at technical freelancers and another directed at technical writers working within organizations. Gives a profile of technical writers in the Netherlands; an impression of the problems technical writers in organizations deal with;…

  6. Aircrew cooperation in the Royal Air Force

    NASA Technical Reports Server (NTRS)

    Adcock, C. B.

    1987-01-01

    The progressive introduction of modern, high performance aircraft, coupled with a significant increase in the complexity of the operational environment, has highlighted crew co-operation as a critical factor in aircraft safety. Investigation into recent MAC aircraft accidents supports the conclusion reached by NASA and other U.S. research institutions that a positive training program is required to improve resource management in the cockpit and prevent a breakdown under stress of the crew process. Past training and regulation has concentrated on the attainment of individual flying skills, but group skills have been neglected through lack of knowledge and understanding of the group process. This long-standing deficiency is now being addressed in the U.S. by the progressive and widespread introduction of theoretical and practical training programs to improve crew co-operation. The RAF should provide similar training for its aircrews through the adaptation and development of existing training resources. Better crew co-operation would not only reduce the number of RAF aircraft accidents but also improve the morale of the Service.

  7. Meteorological variation in daily travel behaviour: evidence from revealed preference data from the Netherlands

    NASA Astrophysics Data System (ADS)

    Creemers, Lieve; Wets, Geert; Cools, Mario

    2015-04-01

    This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation (trip motives) and daily modal choices in the Netherlands. To this end, data from the Dutch National Travel Household Survey of 2008 were matched to hourly weather data provided by the Royal Dutch Meteorological Institute and were complemented with thermal indices to indicate the level of thermal comfort and additional variables to indicate the seasonality of the weather conditions. Two multinomial logit-generalised estimation equations (MNL-GEE) models were constructed, one to assess the impact of weather conditions on trip motives and one to assess the effect of weather conditions on modal choice. The modelling results indicate that, depending on the travel attribute of concern, other factors might play a role. Nonetheless, the thermal component, as well as the aesthetical component and the physical component of weather play a significant role. Moreover, the parameter estimates indicate significant differences in the impact of weather conditions when different time scales are considered (e.g. daily versus hourly based). The fact that snow does not play any role at all was unexpected. This finding can be explained by the relatively low occurrence of this weather type in the study area. It is important to consider the effects of weather in travel demand modelling frameworks because this will help to achieve higher accuracy and more realistic traffic forecasts. These will in turn allow policy makers to make better long-term and short-term decisions to achieve various political goals, such as progress towards a sustainable transportation system. Further research in this respect should emphasise the role of weather conditions and activity-scheduling attributes.

  8. Micro seismic event detection based on neural networks in the Groningen area, The Netherlands

    NASA Astrophysics Data System (ADS)

    Paap, Bob; van Maanen, Peter-Paul; Carpentier, Stefan; Meekes, Sjef

    2017-04-01

    Over the past decades, the Groningen gas field has been increasingly faced by induced earthquakes resulting from gas production. The seismic monitoring network at Groningen has been densified in order to acquire more accurate information regarding the onset and origin of seismic events, resulting in increasing amounts of seismic data. Although traditional automated event detection techniques generally are successful in detecting events from continuous data, its detection success is challenged in cases of lower signal-to-noise ratios and often limited availability of seismologists. Besides the recent expansion of the Groningen seismic network, additional new seismic networks have been deployed at several geothermal and CO2 storage fields. The data stream coming from these networks has sparked specific interest in neural networks for automated classification and interpretation. Here we explore the feasibility of neural networks in classifying the occurrence of seismic events. For this purpose a three-layered feedforward neural network was trained using public data related to a seismic event in the Groningen gas field obtained from the Royal Netherlands Meteorological Institute (KNMI) data portal. The first arrival times that were determined by KNMI for a subset of the station data were used to determine the arrival times for the other station data. Different derivatives, using different frequency sub-band and STA/LTA settings, were used as input. Based on these data, the network's parameters were then optimized to predict arrival times accurately. Although this study is still ongoing, we anticipate our approach can significantly increase the performance as compared to detection methods usually applied to the Groningen gas field. This will clear the way for future real-time micro seismic event classification.

  9. Royal Jelly: An ancient remedy with remarkable antibacterial properties.

    PubMed

    Fratini, Filippo; Cilia, Giovanni; Mancini, Simone; Felicioli, Antonio

    2016-11-01

    Royal Jelly (RJ), a honeybee hypopharyngeal gland secretion of young nurse and an exclusive nourishment for bee queen, has been used since ancient times for care and human health and it is still very important in traditional and folkloristic medicine, especially in Asia within the apitherapy. Recently, RJ and its protein and lipid components have been subjected to several investigations on their antimicrobial activity due to extensive traditional uses and for a future application in medicine. Antimicrobial activities of crude Royal Jelly, Royalisin, 10-hydroxy-2-decenoic acid, Jelleines, Major Royal Jelly Proteins against different bacteria have been reported. All these beehive products showed antimicrobial activities that lead their potential employment in several fields as natural additives. RJ and its derived compounds show a highest activity especially against Gram positive bacteria. The purpose of this Review is to summarize the results of antimicrobial studies of Royal Jelly following the timescale of the researches. From the first scientific applications to the isolation of the single components in order to better understand its application in the past years and propose an employment in future studies as a natural antimicrobial agent.

  10. Plant Guide: Royal penstemon: Penstemon speciosus Douglas ex Lindl

    Treesearch

    Derek Tilley; Dan Ogle; Loren St. John; Nancy Shaw

    2009-01-01

    Royal penstemon is chiefly used as a forb component for wildlife habitat enhancement projects and restoration efforts. Its showy flowers attract numerous pollinators and other insects which provide a food source for birds and other vertebrates. This species is also commonly used in xeriscaping and other low-water-use landscaping. It is also suited for roadsides and...

  11. Louise Bourgeois (1563-1636): royal midwife of France.

    PubMed

    Dunn, P M

    2004-03-01

    Louise Bourgeois was the first practicing midwife to write of her experience of childbirth and of women's problems. She did much to enhance the respect in which her craft was held. For 26 years she was midwife to the royal court.

  12. 1. Photocopy of measured drawing (original delineated by the Royal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of measured drawing (original delineated by the Royal Danish Academy of Fine Arts (Kunstakademiets), Copenhagen, Denmark, 1961) WEST ELEVATIONS AND PLAN OF UPPER DRONNINGENSGADE - Dronningensgade Area Study, Ninty-nine Steps, 30-31 Queen Street, Charlotte Amalie, St. Thomas, VI

  13. FACILITY 1042. FRONT OBLIQUE SHOWING ROYAL PALMS LINING FRONT WALK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACILITY 1042. FRONT OBLIQUE SHOWING ROYAL PALMS LINING FRONT WALK. VIEW FACING SOUTHEAST - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Junior Officers' Quarters Type, 9-10 Hale Alii Avenue, 1-2 Eighth Street, Pearl City, Honolulu County, HI

  14. ROYAL PALMLINED WALK TO FACILITY 1041 (QUARTERS J) WITH FACILITY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ROYAL PALM-LINED WALK TO FACILITY 1041 (QUARTERS J) WITH FACILITY 1040 (QUARTERS 1) TO LEFT. TAKEN AT CORNER OF HALE ALII AVENUE AND EIGHTH STREET. VIEW FACING EAST. - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Hale Alii Avenue, Eighth Street, & Avenue D, Pearl City, Honolulu County, HI

  15. Photovoltaic-powered refrigerator experiment at Isle Royale National Park

    NASA Technical Reports Server (NTRS)

    Ratajczak, A. F.

    1977-01-01

    The use of a photovoltaic power system to operate an electric refrigerator at a trail construction camp at Isle Royale, Michigan is investigated. The use of P/V power for refrigeration in a remote installation is demonstrated. System design as well as predicted and measured system performance are presented.

  16. Identification of a Novel Hypocholesterolemic Protein, Major Royal Jelly Protein 1, Derived from Royal Jelly

    PubMed Central

    Asai, Saori; Kusada, Mio; Watanabe, Suzuyo; Kawashima, Takuji; Nakamura, Tadashi; Shimada, Masaya; Goto, Tsuyoshi; Nagaoka, Satoshi

    2014-01-01

    Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study, we set out to identify the bile acid-binding protein contained in RJ, because dietary bile acid-binding proteins including soybean protein and its peptide are effective in ameliorating hypercholesterolemia. Using a cholic acid-conjugated column, we separated some bile acid-binding proteins from RJ and identified the major RJ protein 1 (MRJP1), MRJP2, and MRJP3 as novel bile acid-binding proteins from RJ, based on matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Purified MRJP1, which is the most abundant protein of the bile acid-binding proteins in RJ, exhibited taurocholate-binding activity in vitro. The micellar solubility of cholesterol was significantly decreased in the presence of MRJP1 compared with casein in vitro. Liver bile acids levels were significantly increased, and cholesterol 7α-hydroxylase (CYP7A1) mRNA and protein tended to increase by MRJP1 feeding compared with the control. CYP7A1 mRNA and protein levels were significantly increased by MRJP1 tryptic hydrolysate treatment compared with that of casein tryptic hydrolysate in hepatocytes. MRJP1 hypocholesterolemic effect has been investigated in rats. The cholesterol-lowering action induced by MRJP1 occurs because MRJP1 interacts with bile acids induces a significant increase in fecal bile acids excretion and a tendency to increase in fecal cholesterol excretion and also enhances the hepatic cholesterol catabolism. We have identified, for the first time, a novel hypocholesterolemic protein, MRJP1, in RJ. Interestingly, MRJP1 exhibits greater hypocholesterolemic activity than the medicine β-sitosterol in rats. PMID:25144734

  17. More than royal food - Major royal jelly protein genes in sexuals and workers of the honeybee Apis mellifera

    PubMed Central

    2013-01-01

    Background In the honeybee Apis mellifera, female larvae destined to become a queen are fed with royal jelly, a secretion of the hypopharyngeal glands of young nurse bees that rear the brood. The protein moiety of royal jelly comprises mostly major royal jelly proteins (MRJPs) of which the coding genes (mrjp1-9) have been identified on chromosome 11 in the honeybee’s genome. Results We determined the expression of mrjp1-9 among the honeybee worker caste (nurses, foragers) and the sexuals (queens (unmated, mated) and drones) in various body parts (head, thorax, abdomen). Specific mrjp expression was not only found in brood rearing nurse bees, but also in foragers and the sexuals. Conclusions The expression of mrjp1 to 7 is characteristic for the heads of worker bees, with an elevated expression of mrjp1-4 and 7 in nurse bees compared to foragers. Mrjp5 and 6 were higher in foragers compared to nurses suggesting functions in addition to those of brood food proteins. Furthermore, the expression of mrjp9 was high in the heads, thoraces and abdomen of almost all female bees, suggesting a function irrespective of body section. This completely different expression profile suggests mrjp9 to code for the most ancestral major royal jelly protein of the honeybee. PMID:24279675

  18. Making Kew Observatory: the Royal Society, the British Association and the politics of early Victorian science.

    PubMed

    Macdonald, Lee T

    2015-09-01

    Built in 1769 as a private observatory for King George III, Kew Observatory was taken over in 1842 by the British Association for the Advancement of Science (BAAS). It was then quickly transformed into what some claimed to be a 'physical observatory' of the sort proposed by John Herschel - an observatory that gathered data in a wide range of physical sciences, including geomagnetism and meteorology, rather than just astronomy. Yet this article argues that the institution which emerged in the 1840s was different in many ways from that envisaged by Herschel. It uses a chronological framework to show how, at every stage, the geophysicist and Royal Artillery officer Edward Sabine manipulated the project towards his own agenda: an independent observatory through which he could control the geomagnetic and meteorological research, including the ongoing 'Magnetic Crusade'. The political machinations surrounding Kew Observatory, within the Royal Society and the BAAS, may help to illuminate the complex politics of science in early Victorian Britain, particularly the role of 'scientific servicemen' such as Sabine. Both the diversity of activities at Kew and the complexity of the observatory's origins make its study important in the context of the growing field of the 'observatory sciences'.

  19. The library of the Royal Society of Physicians in Budapest becomes today's Semmelweis Medical History Library.

    PubMed

    Kaproncszay, Katalin; Magyar, László András; Putnam, Constance E

    2011-01-01

    The 170-year history of the library of the Royal Society of Medicine in Budapest illustrates both that political and cultural context matter and that "medical" libraries, if they survive, in due course become primarily "medical history" libraries. Two of the authors are on the staff of the Semmelweis Medical History Library; the third is a US scholar who makes frequent use of the library. Together, they avail themselves of archival and published materials-and personal experience with the collection-to establish the context that produced the original library, trace its evolution, and describe its present-day incarnation. A tale of transformation emerges that reflects how collections are likely to change. The authors present events and individuals in the life of the Royal Society's library and paint a picture of the value of today's Semmelweis Medical History Library. Unique treasures in the collection are described. The story told here is of how a particular nineteenth-century library became a twenty-first-century institution. The authors establish its peculiarly Hungarian context and potential value to librarians and historians from outside Hungary. The overall message is that general medical libraries everywhere are perforce likely to become medical historical libraries over time.

  20. [Spanish medicine and surgery in the eighteenth century: the Royal College of Cadiz].

    PubMed

    Cabrera-Afonso, Juan Rafael

    2008-01-01

    We revise the condition of Spanish Surgery and Medicine, at first half of XVIII century, to appraise the labour of Seniors Surgeons of the Navy, Juan Lacomba first and Pedro Virgili after, both creators of The Royal College of Surgery of Cádiz in 1748. This Institution making the renewal of medical and surgical knowledge in the second half of the eighteenth century. In base to original documentation, summarizes the methods and conditions of teaching, pupils, teachers of subjects, from "Clinical Sessions" (sensu lato), the Library, etc. We valued innovative creations of the Botanical Garden of Medicinal Plants, the Cabinet of Natural History and the first shipment of Collegiate Scholars abroad, the edition of new books on various medical, surgical, and other topics, and so on. This led, in 1791, the constitution of the "Miracle of Cádiz" which is just in a single "Carrera", in only one title and one professional to Medicine and Surgery being held in the College of Cádiz and is exported rapidly to the rest of the West. Which expresses the relation what José Celestino Mutis had with the Royal College, where he was to then develop their skills in New Granada, in Colombia today. The College published in Cádiz and in 1792, his Instruccion ... relativa de las especies y virtudes de la Quina [Instructions ... on the species and the virtues of Quina], which is the only publication during his life in Spanish peninsular territory.

  1. The Library of the Royal Society of Physicians in Budapest becomes today's Semmelweis Medical History Library

    PubMed Central

    Kaproncszay, Katalin; Magyar, László András; Putnam, Constance E

    2011-01-01

    Objectives: The 170-year history of the library of the Royal Society of Medicine in Budapest illustrates both that political and cultural context matter and that “medical” libraries, if they survive, in due course become primarily “medical history” libraries. Methods: Two of the authors are on the staff of the Semmelweis Medical History Library; the third is a US scholar who makes frequent use of the library. Together, they avail themselves of archival and published materials—and personal experience with the collection—to establish the context that produced the original library, trace its evolution, and describe its present-day incarnation. Results: A tale of transformation emerges that reflects how collections are likely to change. The authors present events and individuals in the life of the Royal Society's library and paint a picture of the value of today's Semmelweis Medical History Library. Unique treasures in the collection are described. Conclusion: The story told here is of how a particular nineteenth-century library became a twenty-first–century institution. The authors establish its peculiarly Hungarian context and potential value to librarians and historians from outside Hungary. The overall message is that general medical libraries everywhere are perforce likely to become medical historical libraries over time. PMID:21243053

  2. The development of HIV research laboratories in the Royal Thai Army Medical Department.

    PubMed

    Chuenchitra, Thippawan; Sukwit, Suchitra; Gaywee, Jariyanart; Viputtikul, Kwanjai; Eamsila, Chirapa; Tabprasit, Sutchana; de Souza, Mark; Sirisopana, Narongrid; Nitayaphan, Sorachai; Brown, Arthur E; Chuenchitra, Cheodchai

    2005-11-01

    The development of HIV research laboratories at the Armed Forces Research Institute of Medical Sciences (AFRIMS), Royal Thai Army Medical Department in supporting of HIV-1 vaccine trials in Thailand was implemented in 1991. The collaboration between AFRIMS, Royal Thai Army Medical Department, and the US Military HIV Research Program with the ultimate goal to conduct the HIV-1 vaccine trial phase III. The HIV serology lab was set up for surveillance program in military recruits. Then, there was a need to strengthen more on the existing laboratories by training personnel to cope with the confidentiality of the lab results, specimen processing and data management which are critical. Later on, the necessary laboratory for measuring of vaccine immunogenicity was developed, such as lymphoproliferation assay. Additionally, a molecular biology lab was also developed. The HIV research laboratory management must include an ability to deal with some problems, such as late specimen receiving, fluctuating of power supply, technical staffs maintained. Good laboratory practices and safety must be strictly implemented. Communication network among facilities also played an important role in HIV laboratory strengthening at AFRIMS.

  3. The Royal College of Psychiatrists and the death penalty.

    PubMed

    Gunn, John

    2004-01-01

    The Royal College of Psychiatrists recently issued a revised statement on its position concerning capital punishment. The College proposes to support psychiatrists who refuse to be involved in the capital process, but accepts that some may take up limited involvement in the manner set out in the document. The Royal College is the professional body for psychiatric practitioners in the United Kingdom and Ireland. Almost no public statements are issued from the College without first being deliberated on within at least two of its three major committees. The new document on capital punishment remains in the spirit of the previous ones. The topic of capital punishment is noncontroversial within the British medical profession. In all European countries, capital punishment is against the law, because there is an overarching directive from the Council of Europe (a wide group of nations, wider than the European Union) insisting that it be abolished.

  4. Population limitation and the wolves of Isle Royale

    USGS Publications Warehouse

    Peterson, R.O.; Thomas, N.J.; Thurber, J.M.; Vucetich, J.A.; Waite, T.A.

    1998-01-01

    Population regulation for gray wolves in Isle Royale National Park, Michigan, was ex- amined in 1987-1995 when wolves were in chronic decline following a crash of the pop- ulation in 1981-1982. Canine parvovirus (CPV-2) was probably influential during the crash, but it disappeared by the lae 1980s. High mortality abruptly ceased after 1988, but low recruitment in the absence of disease and obvious shortage of food prevented recovery of the wolf population. In 1983-1995, with a comparable number of moose '10 years old as potential prey, wolves were only half as numerous as in 1959-1980. A simulation of annual fluctuations in effective population size (Ne) for wolves on Isle Royale suggests that their genetic heterozygosity has declined ca. 13% with each generation and ca. 80% in the 50- year history of this population. Inbreeding depression and stochastic demographic variation both remain possible explanations for recent low recruitment.

  5. [New Royal Decree on clinical trials: main implications for emergency medicine physicians who do research].

    PubMed

    García Arenillas, Mar; Haj-Ali Saflo, Okba; Sáenz de Tejada, Marta

    2017-06-01

    The new European Union directives affecting clinical trials of medicines introduced important changes for Spain, leading to the publication of a Royal Decree regulating the conduct of clinical trials that went into effect in January 2016. The decree sets out the principles for complying with the EU directives, regulates the work of institutional review boards (IRBs) or ethics committees that review research proposals, introduces means to facilitate clinical research, and clarifies the role of the Spanish register of clinical trials, among other topics. This paper discusses the main changes that have been introduced, especially those intended to facilitate research, such as the new concepts of low intervention trial and noncommercial clinical research. These concepts may be particularly useful for clinical trials designed by emergency medicine physicians. We also comment on changes affecting vulnerable populations and the documents that must be presented to both the researchers' IRB and the Spanish Agency for Medicines and Health Care Products.

  6. The Magnetic Observatory Buildings at the Royal Observatory, Cape

    NASA Astrophysics Data System (ADS)

    Glass, I. S.

    2015-10-01

    During the 1830s there arose a strong international movement, promoted by Carl Friedrich Gauss and Alexander von Humboldt, to characterise the earth's magnetic field. By 1839 the Royal Society in London, driven by Edward Sabine, had organised a "Magnetic Crusade" - the establishment of a series of magnetic and meteorological observatories around the British Empire, including New Zealand, Australia, St Helena and the Cape. This article outlines the history of the latter installation, its buildings and what became of them.

  7. A Vision in Jeopardy: Royal Navy Maritime Autonomous Systems (MAS)

    DTIC Science & Technology

    2017-03-31

    Successive UK governments have recognized the enduring importance of maritime power for Britain as an island nation and have directed the Royal...transformations to analyze the importance of vision to the success of a program, the cultural and leadership frictions within the RN, and the...water.” i Abstract Successive UK governments have recognized the enduring importance of maritime power for Britain as an island nation and

  8. John Tyndall and the Royal Medal that was never struck

    PubMed Central

    Jackson, Roland

    2014-01-01

    Just once in its long history has a Royal Medal been awarded but not presented. John Tyndall FRS (1820–93) was the chosen recipient in 1853 for his early work on diamagnetism but declined to accept it. The story of why Tyndall felt compelled to turn down this considerable honour sheds light on the scientific politics and personal relationships of the time, on the importance given to the study of magnetism, and on Tyndall's own character and career. PMID:24921107

  9. Whitening Effect of Watersoluble Royal Jelly from South Korea.

    PubMed

    Han, Sang Mi; Kim, Jung Min; Hong, In Phyo; Woo, Soon Ok; Kim, Se Gun; Jang, Hye Ri; Park, Kwan Kyu; Pak, Sok Cheon

    2015-01-01

    Royal jelly has been widely used as a health supplement worldwide. However, royal jelly has been implicated in allergic reactions, and we developed a water-soluble royal jelly (WSRJ) without the allergy inducing protein. In this study, we aimed to identify the anti-melanogenic efficacy of WSRJ. B16F1 melanoma cells were first treated with 10 nM α-melanocyte stimulating hormone (α-MSH) and then with various doses of WSRJ. In addition, we investigated the mRNA and protein expression of melanogenesis-related genes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and TRP-2 by reverse transcription-polymerase chain reaction and western blotting. WSRJ directly inhibited tyrosinase and cellular tyrosinase activity, which decreased melanin synthesis in α-MSH stimulated B16F1 melanoma cells a level comparable to that observed with arbutin. WSRJ decreased the mRNA and protein expressions of tyrosinase, TRP-1, and TRP-2, which was comparable to that observed with arbutin. WSRJ has strong anti-melanogenic activity, which invoice direct inhibition of tyrosinase enzyme activity and suppression of expression of melanogenesis related genes. Results from this study suggests that WSRJ is a potential candidate for the treatment of skin pigmentation.

  10. Geohydrologic data from Port Royal Sound, Beaufort County, South Carolina

    USGS Publications Warehouse

    Burt, R.A.; Belval, D.L.; Crouch, Michael; Hughes, W.B.

    1986-01-01

    Nine offshore wells were drilled through overlying sediments into the Upper Floridan aquifer in Port Royal Sound, South Carolina and the adjacent Atlantic Ocean, to obtain geologic, hydrologic, and water quality data. The Upper Floridan aquifer consists predominantly of light-gray, poorly consolidated, fossiliferous limestone. In the Port Royal Sound area, the Upper Floridan is overlain by olive-gray, medium to course sand and silty sand. Falling-head permeability tests on these overlying clastic sediments indicate permeabilities of 1,100 to 4.3 x 10 to the 7th power centimeters/sec. Other geologic and hydrologic data, including geophysical logs, sieve analyses, and detailed core descriptions were obtained, along with continuous water level records of the wells, tidal records, and barometric pressure records. Water collected from the Upper Floridan aquifer beneath Port Royal Sound and the ocean ranged in concentration of chloride from 54 to 12,000 mg/l. Measured pH ranged from 6.8 to 8.4, and alkalinity ranged from 122 to 368 mg/l as CaC03. Other water quality data obtained include temperature, specific conductance, carbon-13, carbon-14, tritium , deuterium, oxygen-18, dissolved oxygen, dissolved solids, nitrogen species, phosphorus, organic carbon, cyanide, sulfide, calcium, magnesium, sodium, potassium, sulfate, fluoride, silica , bromide, iodide, and selected trace metals. (USGS)

  11. Functional properties of honey, propolis, and royal jelly.

    PubMed

    Viuda-Martos, M; Ruiz-Navajas, Y; Fernández-López, J; Pérez-Alvarez, J A

    2008-11-01

    Honey, propolis, and royal jelly, products originating in the beehive, are attractive ingredients for healthy foods. Honey has been used since ancient times as part of traditional medicine. Several aspects of this use indicate that it also has functions such as antibacterial, antioxidant, antitumor, anti-inflamatory, antibrowning, and antiviral. Propolis is a resinous substance produced by honeybees. This substance has been used in folk medicine since ancient times, due to its many biological properties to possess, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects, among others. Royal jelly has been demonstrated to possess numerous functional properties such as antibacterial activity, anti-inflammatory activity, vasodilative and hypotensive activities, disinfectant action, antioxidant activity, antihypercholesterolemic activity, and antitumor activity. Biological activities of honey, propolis, and royal jelly are mainly attributed to the phenolic compounds such as flavonoids. Flavonoids have been reported to exhibit a wide range of biological activities, including antibacterial, antiviral, anti-inflammatory, antiallergic, and vasodilatory actions. In addition, flavonoids inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and the activity of enzyme systems including cyclo-oxygenase and lipoxygenase.

  12. Institute news

    NASA Astrophysics Data System (ADS)

    1999-11-01

    : Heriot-Watt University 4 Nov: Strathclyde University 17 Nov: York University 24 Nov: Bristol University 1 Dec: Open University 7 Dec: Kent University 14 Dec: Cardiff University 15 Dec: University of Wales, Swansea 24 Jan: Reading University 10 Feb: Abingdon School 16 Feb: Plymouth University 2 Mar: Sheffield University 7 Mar: CLRC Daresbury Laboratory 8 Mar: Liverpool University 9 Mar: Manchester 10 Mar: Lancaster University 15 Mar: Surrey University 16 Mar: Brighton University 17 Mar: St Vincent College, Gosport 22 Mar: Leeds University 23 Mar: Loughborough Grammar School 24 Mar: Oakham School 30 Mar: St Peter's School, Wolverhampton 18 May: University of Hertfordshire 11 Jul: Science Museum 12 Jul: Royal Institution The assistance of the Engineering and Physical Sciences Research Council, CLRC Daresbury Laboratory and DERA Malvern is acknowledged in staging this year's events. Courses, lectures and competitions `Physics in perspective', the study course for sixth-formers and college students, will take place in London on 6 - 8 February 2000, offering insights into many different aspects of physics. The programme commences during the afternoon of Sunday 6 February at King's College London with a Balloon debate, followed by Brian O'Rourke's talk on the `Physics of Formula 1 cars'. On Monday 7 February at the Royal Institution, John Avison (former Honorary Editor of Physics Education) will develop the `Thinking physics' theme by presenting the audience with varied topics in an unusual and challenging way. The second talk of the afternoon, by Professor Roy Sambles, will cover `Lasers, light and liquid crystals'. On the final day (Tuesday 8 February), again at the Royal Institution, Sara Ellison will lead the audience in `Heavenly pursuits', whilst later Dr Colin Wright will entertain with `Juggling - theory and practice'. Futher information and bookings for the course can be made by contacting Mrs Leila Solomon at The Institute of Physics, 76 Portland Place, London W1N 3DH

  13. Netherlands Antilles: country profile.

    PubMed

    Thorndike, T

    1988-03-01

    The Netherlands Antilles is the former name for the 5 islands called "the Antilles of the Five" (Curacao, Bonaire, St Maarten, St Eustatius, and Saba) and the separatist (since 1986) island of Aruba, which has its own prime minister (Henny Eamon -- the prime minister of the other 5 islands is Don Martina). The total 1988 population is 264,000. They enjoy one of the highest standards of living among the developing countries, with a per capita gross national product of $1610 guilder ($15,390 (US). Health services, life expectancy, and political freedom are excellent, due mainly to Dutch standards and aid. The position of women is also generally progressive. Literacy is excellent despite the different languages used (Dutch and Papiamento in Curacao, Bonaire and Aruba; English in St Maarten, St Eustatius, and Saba). Since the 2 major industries (oil refining and offshore financial services) have collapsed, tourism is limited mainly to the Windward Islands (St Eustatius and Saba), and there is no agriculture or fishing, the country's high standard of living is due to $530 million of Dutch aid, on which the country relies. Aruba will become independent in 1996, a future opposed by nearly all the 67,000 islanders, who fear it will mean the loss of Dutch aid.

  14. Family and family therapy in the Netherlands.

    PubMed

    Wagenaar, Karin; Baars, Jan

    2012-04-01

    This article describes how families are functioning in the Netherlands, and how family therapy is used in mental healthcare. In the open Dutch society, new ideas are easily incorporated, as exemplified by the rapid introduction and growth of family therapy in the 1980s. In recent decades, however, family therapy has lost ground to other treatment models that are more individually orientated, and adhere to stricter protocols. This decline of family therapy has been exacerbated by recent budget cuts in mental healthcare. In regular healthcare institutes family therapy now has a marginal position at best, although family treatment models are used in specific areas such as forensic treatments. In addition, the higher trained family therapists have found their own niches to work with couples and families. We argue that a stronger position of family therapy would be beneficial for patients and for families, in order to counteract the strong individualization of Dutch society.

  15. [First outbreak of bluetongue in goats in The Netherlands].

    PubMed

    Dercksen, D; Groot Nibbelink, N; Paauwe, R; Backx, A; van Rijn, P; Vellema, P

    2007-10-15

    For the first time, bluetongue has been diagnosed in goats in the Netherlands and in Northwest-Europe. On the 17th of August 2006, bluetongue was for the first time diagnosed in sheep and a little later in cattle in The Netherlands. The clinical symptoms, diagnostics and differential diagnosis of bluetongue (BT) in goats in the Netherlands are described. The most obvious clinical signs were an acute drop in milk production and high fever (up to 42 degrees C). Clinical signs were less obvious than usually seen for clinically diseased sheep and cattle. A few goats showed oedema of the lips and the head, some nasal discharge and scabs on the nose and lips. Further erythema of the skin of the udder and small subcutaneous hemorrhages were seen. Just like one year ago, for the very first suspicion of bluetongue in Northwest-Europe, a good collaboration between practitioners, specialists of the Animal Health Service (GD Deventer), the Specialist Team of the Food and Consumer Product Safety Authority (VWA), and the Central Institute for animal Disease Control (CIDC-Lelystad) in The Netherlands, led to the first and rapid notification and confirmation of the suspicion of bluetongue.

  16. KIBOWI: A Training Wargame for the Royal Netherlands Army (KIBOWI: Een Training Wargame voor de Koninklijke Landmacht)

    DTIC Science & Technology

    1989-12-01

    gebruik van het model heeft plaatsgevonden gedurende 1988 en 1989 voor circa 20 weken op bataljonsniveau. Ervaring in het gebruik van het prototype...representatie en eenheidsinteractie (detectie, direct vuur, etc.). TNO report Page 4 CONTENTS ABSTRACT 1 SAMENVATTING 2 CONTENTS 4 1 INTRODUCTION 6 2 THE...processes, readjusting for hardware failures, making backups, restarts, etc. 2. Database manager To create exercise databases and to facilitate and

  17. The geologic story of Isle Royale National Park

    USGS Publications Warehouse

    Huber, N. King

    1975-01-01

    Isle Royale is an outstanding example of relatively undisturbed northwoods lake wilderness. But more than simple preservation of such an environment is involved in its inclusion in our National Park System. Its isolation from the mainland provides an almost untouched laboratory for research in the natural sciences, especially those studies whose very nature depends upon such isolation. One excellent example of such research is the intensive study of the predator-prey relationship of the timber wolf and moose, long sponsored by the National Park Service and Purdue University. In probably no other place in North America are the necessary ecological conditions for such a study so admirably fulfilled as on Isle Royale. The development of a natural laboratory with such conditions is ultimately dependent upon geologic processes and events that although not unique in themselves, produced in their interplay a unique result, the island archipelago as we know it today, with its hills and valleys, swamps and bogs the ecological framework of the plant and animal world. Even the most casual visitor can hardly fail to be struck by the fiordlike nature of many of the bays, the chains of fringing islands, the ridge-and-valley topography, and the linear nature of all these features. The distinctive topography of the archipelago is, of course, only the latest manifestation of geologic processes in operation since time immemorial. Fragments of geologic history going back over a billion years can be read from the rocks of the island, and with additional data from other parts of the Lake Superior region, we can fill in some of the story of Isle Royale. After more than a hundred years of study by man, the story is still incomplete. But then, geologic stories are seldom complete, and what we do know allows a deeper appreciation of one of our most naturally preserved parks and whets our curiosity about the missing fragments.

  18. Clinical photograph from the Royal Infirmary of Edinburgh - 1853.

    PubMed

    Malcolm-Smith, N A

    2005-10-01

    A child with a facial defect is presented using clinical details recorded in a ward journal of the Royal Infirmary of Edinburgh for 1853. The entry in the journal is illustrated by a clinical photograph and a pen and ink drawing. The operation for facial reconstruction is described together with an account of post-operative course and outcome. The differential diagnoses and views on the aetiology of the patient's disorder are considered. The photograph itself is described and the historical and social background of the patient are outlined.

  19. The Royal Society and the decline of magic.

    PubMed

    Hunter, Michael

    2011-06-20

    Whereas some have asserted that the early Royal Society actively sought to discredit magical beliefs, others have seen ideas of this kind as integral to the Society's 'nature' in its early years. This paper argues that, whatever the magical commitments of individual Fellows, the Society's corporate policy simply sidelined such pursuits. Yet, insofar as the result was that magic was excluded by default from the proper realm of scientific enquiry, this attitude was to prove paradoxically influential (although its roots have been retrospectively misconstrued to an extent that is significant in itself).

  20. Royal Society offers funds for technology start-ups

    NASA Astrophysics Data System (ADS)

    Clery, Daniel

    2008-04-01

    Scientists with a good idea ripe for commercial exploitation will no longer have to hawk their wares to bankers and private investors to get financial backing: the Royal Society is also about to get into the venture-capital business. The society is planning to set up an enterprise fund to buy equity in start-up companies based on outstanding technology - covering everything from renewable energy and carbon capture to water purification. "If there are difficulties getting science into the marketplace, the society has a role helping with that," says chemical physicist Andrew Mackintosh, a former chief executive of Oxford Instruments who has been brought in to manage the fund.

  1. A Compact Geography of the Netherlands. [Revised.

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    This short booklet on the geography of the Netherlands, designed for use at the upper elementary and secondary levels, contains 17 short descriptive analyses of Dutch physical and human geography. Each section is well illustrated with diagrams and maps. Titles of the sections include (1) High Netherlands--Low Netherlands, (2) Land Reclamation, (3)…

  2. Educational and Nonprofit Institutions Receiving Prime Contract Awards for RDT&E (Research, Development, Test and Evaluation), Fiscal Year 1988.

    DTIC Science & Technology

    1988-01-01

    UNIVERSITY OF PUERTO RICO 185 UNIVERSITY OF MARYLAND 13,292 * Rio Piedras PUERTO RIC 135 CHILE 277 San Juan PUERTO RIC 50 Denver Colorado 88 UasI’Engton...UNITED KIN 60 FRANCE 206 ROYAL INSTITUTION 35 CENTRO DI CULTURA SCIENTIFICA 33 * UNITED KIN 35 ITALY 33 ROYAL NORWEGIAN NAVAL MATERIAL 15,621

  3. Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis

    PubMed Central

    Yamaura, Katsunori; Tomono, Ayana; Suwa, Eriko; Ueno, Koichi

    2013-01-01

    Background: Royal jelly is widely used as a health tonic, especially in Asia. Royal jelly is commonly used in cosmetics as well as in dietary supplements and beverages. Little is known, however, about the pharmacologic efficacy of topical royal jelly. Therefore, we investigated the antipruritic activity of topical royal jelly on chronic pruritus in experimental allergic contact dermatitis in mice. Materials and Methods: Hairless mice (HOS: HR-1), with chronic allergic contact dermatitis induced by 5 weeks of repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) to the entire back skin were treated topically with royal jelly (0.01% or 1%) for 5 weeks after sensitization with TNCB. The effects of royal jelly on pruritus and inflammation were evaluated by measurement of scratching behavior and skin inflammation score, respectively. Results: Repeated application of TNCB to the back skin of mice elicited frequent scratching behavior immediately and 24h after challenge. Topical royal jelly (0.01% or 1%) and betamethasone (0.01%) significantly ameliorated this chronic pruritus throughout the experimental period. The level of nerve growth factor mRNA in back skin was increased in the mice with dermatitis and reduced by betamethasone, but not by royal jelly. Conclusion: The inhibitory effect of royal jelly on chronic pruritus may occur through different mechanisms from those of betamethasone. Topical application of royal jelly, as used in cosmetics, might be beneficial for the alleviation of chronic pruritus. PMID:23661987

  4. Effectiveness of submerged drains in reducing subsidence of peat soils in agricultural use, and their effects on water management and nutrient loading of surface water: modelling of a case study in the western peat soil area of The Netherlands

    NASA Astrophysics Data System (ADS)

    Hendriks, Rob F. A.; van den Akker, Jan J. A.

    2017-04-01

    conditions and for two extreme climate scenarios of the Royal Netherlands Meteorological Institute. In this study the model results of one of the pilot studies are presented. The case study 'de Krimpenerwaard' is situated in the peat area in the "Green Heart" between the major cities of Amsterdam, The Hague, Rotterdam and Utrecht. Model results show a halving of soil subsidence, a strong increase of water recharge but a lower increase of water discharge, and generally small to moderate effects on nutrient loading , all depending (strongly) on meteorological conditions.

  5. [Medical care at the Royal Hospital of Natives].

    PubMed

    Romero-Huesca, Andrés; Ramírez-Bollas, Julio

    2003-01-01

    After the Conquest, the indigenous populations of New Spain were left unprotected by the new government. Thus the Royal Hospital of Naturals (RHN) was created, offering care to the indigenous population for health and with hospitality, as well as religious aid. However, later solely care was provided. The RHN had great support from the Spanish Crown and became a suitable place for clinical investigation that on the peninsula and in all of Europe was forbidden: the autopsies, that in indigenous population are carried out without sanction, only needing authorization of local authorities for their accomplishment, considering the indigenous as inferior to Spaniards. In addition, the RHN was the best place for foundation of the Royal Surgery School of Mexico in the XVIII century. The contribution of the RHN was the fusion of indigenous medicine with European medicine, increasing the therapeutic resource array, as well as the opportunity of carrying clinic investigation through autopsy's for better clinic correlation, and matchless learning for the era in the art of out surgery, this being an important point in the development of the medicine and surgery of Mexico.

  6. Genetic royal cheats in leaf-cutting ant societies.

    PubMed

    Hughes, William O H; Boomsma, Jacobus J

    2008-04-01

    Social groups are vulnerable to cheating because the reproductive interests of group members are rarely identical. All cooperative systems are therefore predicted to involve a mix of cooperative and cheating genotypes, with the frequency of the latter being constrained by the suppressive abilities of the former. The most significant potential conflict in social insect colonies is over which individuals become reproductive queens rather than sterile workers. This reproductive division of labor is a defining characteristic of eusocial societies, but individual larvae will maximize their fitness by becoming queens whereas their nestmates will generally maximize fitness by forcing larvae to become workers. However, evolutionary constraints are thought to prevent cheating by removing genetic variation in caste propensity. Here, we show that one-fifth of leaf-cutting ant patrilines cheat their nestmates by biasing their larval development toward becoming queens rather than workers. Two distinct mechanisms appear to be involved, one most probably involving a general tendency to become a larger adult and the other relating specifically to the queen-worker developmental switch. Just as evolutionary theory predicts, these "royal" genotypes are rare both in the population and within individual colonies. The rarity of royal cheats is best explained as an evolutionary strategy to avoid suppression by cooperative genotypes, the efficiency of which is frequency-dependent. The results demonstrate that cheating can be widespread in even the most cooperative of societies and illustrate that identical principles govern social evolution in highly diverse systems.

  7. Pictorial Atlas of the Netherlands.

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    The atlas contains almost 40 photographs and 40 maps of geographical aspects of the Netherlands: the coast, dikes, canals, towns, and farmland. Each page contains a photograph, a section of a map showing the area in which the photograph was taken, and a discussion of several paragraphs about the geographical problems of the area and how they have…

  8. Pictorial Atlas of the Netherlands.

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    The atlas contains almost 40 photographs and 40 maps of geographical aspects of the Netherlands: the coast, dikes, canals, towns, and farmland. Each page contains a photograph, a section of a map showing the area in which the photograph was taken, and a discussion of several paragraphs about the geographical problems of the area and how they have…

  9. Higher Education in the Netherlands.

    ERIC Educational Resources Information Center

    de Moor, R. A.

    There are two sectors of higher education in the Netherlands: the universities covered by the University Education Act and the vocationally-oriented colleges covered by the Further Education Act. Following a summary of the main elements of secondary education, higher or tertiary education is defined. Thirteen universities and non-university…

  10. [The National Royal Academy of Medicine and the Civil War (1936-1939)].

    PubMed

    Sánchez Granjel, Luis

    2006-01-01

    The Civil war (1936-1939) caused the most serious crisis in the history of the National Royal Academy of Medicine. The Government of the Republic ordered its dissolution in September 1936, and they proposed the creation of a higher organization, "The National Institute of Culture", whose main aim was to join all the Academies that had become sections and that were rigidly controlled by the political power; the course of the war sotpped this project being carried out. In the army-dominated Spain there was a similar process; the "Institute of Spain" (January, 1938) was created and it joined the National Academies although each of them did not lose its own personality. The Academy of Medicine was established in San Sebastian until 1939, and was managed by Enrique Suñer, with the collaboration of Leonardo de la Peña and Santiago Carro; the three of them were named by the Ministry of National Education. The dispersion of the members of the Academy, who had abandoned Madrid, did not allow the Academy to develop its traditional scientific activity, which was not restored until the activity was re-established in Madrid in the summer of 1939.

  11. Reproductive technology: in the Netherlands, tolerance and debate.

    PubMed

    De Wachter, Maurice A M; De Wert, Guido MWR

    1987-06-01

    Two ethicists from the Netherlands' Institute for Bioethics file a report on their country in one of six Hastings Center Report articles on the status of reproductive technologies around the world. The situation in the Netherlands reflects the tolerant attitudes of the Dutch toward what are regarded as private matters. Artificial insemination, in vitro fertilization, and surrogate motherhood are available, and research on embryos is in the planning stages. Facilities offering reproductive services are regulated by the Minister of Health, with advice from the independent Health Council on Artificial Reproduction, the National Council for Public Health, and various insurance companies and professional medical organizations. Public policy debates center around such issues as the value of parenthood; involvement of third parties; secrecy about a child's genetic origins; privacy for semen, ovum, and embryo donors; access to services; and insurance coverage of treatment.

  12. 78 FR 77772 - Culturally Significant Objects Imported for Exhibition Determinations: “A Royal Passion: Queen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Photography'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``A Royal Passion: Queen Victoria and Photography,'' imported from abroad for temporary exhibition...

  13. Outbreak of Legionnaires' disease in Glasgow Royal Infirmary: microbiological aspects.

    PubMed Central

    Timbury, M. C.; Donaldson, J. R.; McCartney, A. C.; Fallon, R. J.; Sleigh, J. D.; Lyon, D.; Orange, G. V.; Baird, D. R.; Winter, J.; Wilson, T. S.

    1986-01-01

    The bacteriological investigation of an outbreak of Legionnaires' disease in Glasgow Royal Infirmary affecting 16 patients is described. Most of the patients had been treated in high-dependency areas on two floors of the hospital supplied by the same two air-conditioned ventilation systems. The source of infection was traced to contamination of a cooling tower from which a plume of spray discharged into the intake vents of the two ventilation systems. Rubber grommets within the cooling tower probably provided a nidus of infection there. The control and management of the outbreak are discussed: a policy of frankness about the course and progress of the investigations was adopted and helped to allay anxiety on the part of both staff and media. PMID:3540109

  14. Mapping the royal road and other hierarchical functions.

    PubMed

    Wiles, Janet; Tonkes, Bradley

    2003-01-01

    In this paper we present a technique for visualising hierarchical and symmetric, multi-modal fitness functions that have been investigated in the evolutionary computation literature. The focus of this technique is on landscapes in moderate-dimensional, binary spaces (i.e., fitness functions defined over [0,1](n), for n < or = 16). The visualisation approach involves an unfolding of the hyperspace into a two-dimensional graph, whose layout represents the topology of the space using a recursive relationship, and whose shading defines the shape of the cost surface defined on the space. Using this technique we present case-study explorations of three fitness functions: royal road, hierarchical-if-and-only-if (H-IFF), and hierarchically decomposable functions (HDF). The visualisation approach provides an insight into the properties of these functions, particularly with respect to the size and shape of the basins of attraction around each of the local optima.

  15. Hearing loss in the Royal Norwegian Navy: A longitudinal study

    PubMed Central

    Irgens-Hansen, Kaja; Baste, Valborg; Bråtveit, Magne; Lind, Ola; Koefoed, Vilhelm F.; Moen, Bente E

    2016-01-01

    The aims of this longitudinal study were to investigate a significant threshold shift (STS) among personnel working on board the Royal Norwegian Navy's (RNoN) vessels between 2012 and 2014 and to identify possible determinants of STS. Hearing thresholds were measured by pure tone audiometry in two consecutive examinations (n = 226). STS was defined as an average change in hearing thresholds ≥ + 10 dB at 2,000 Hz, 3,000 Hz, and 4,000 Hz in either ear. Determinants of STS were assessed through a questionnaire. The incidence of STS was 23.0%. Significant determinants of STS were the number of episodes of temporary threshold shifts (TTS) in the Navy, exposure to continuous loud noise during work on board, and the number of gun shots (in the Navy, hunting, and sports). This study indicated a significant association between noise exposure on board Navy vessels and development of STS. PMID:27157689

  16. Compliance of Royal Naval ships with nitrogen oxide emissions legislation.

    PubMed

    Blatcher, D J; Eames, I

    2013-09-15

    Nitrogen oxide (NOx) emissions from marine diesel engines pose a hazard to human health and the environment. From 2021, demanding emissions limits are expected to be applied to sea areas that the Royal Navy (RN) accesses. We analyze how these future constraints affect the choice of NOx abatement systems for RN ships, which are subject to more design constraints than civilian ships. A weighted matrix approach is used to facilitate a quantitative assessment. For most warships to be built soon after 2021 Lean Nitrogen Traps (LNT) in conjunction with Exhaust Gas Recirculation (EGR) represents a relatively achievable option with fewer drawbacks than other system types. Urea-selective catalytic reduction is likely to be most appropriate for ships that are built to civilian standards. The future technologies that are at an early stage of development are discussed.

  17. Survey of spontaneous pneumothoraces in the Royal Air Force

    PubMed Central

    Cran, I. R.; Rumball, C. A.

    1967-01-01

    Nine hundred and ninety-four cases of spontaneous pneumothorax which occurred in Royal Air Force personnel over a period of 22 years are reviewed. They are analysed in relation to age, side of occurrence, activity at the time of onset, and seasonal occurrence. Some clinical and radiological findings are presented and the incidence of recurrence is described (the possible association with emphysematous bullae is mentioned). Methods of treatment are discussed and those found most suitable for the special requirements of R.A.F. personnel are described. Spontaneous pneumothorax is thought to be more commonly diagnosed now and an increasing incidence in the R.A.F. in recent years is demonstrated. PMID:6050294

  18. [Oxidation of luminol with peroxidase from royal palm leaves].

    PubMed

    Alpeeva, I S; Sakharov, I Iu

    2007-01-01

    We optimized the conditions for luminol oxidation by hydrogen peroxide in the presence of peroxidase (EC 1.11.1.7) from royal palm leaves (Roystonea regia). The pH range (8.3-8.6) corresponding to maximum chemiluminescence was similar for palm tree peroxidase and horseradish peroxidase. Variations in the concentration of the Tris buffer were accompanied by changes in chemiluminescence. Note that maximum chemiluminescence was observed in the 30 mM solution. The detection limit of the enzyme assay during luminol oxidation by hydrogen peroxide was 1 pM. The specific feature of palm tree peroxidase was the generation of a long-term chemiluminescent signal. In combination with the data on the high stability of palm tree peroxidase, our results indicate that this enzyme is promising for its use in analytical studies.

  19. Dental caries amongst Royal Australian Navy recruits, 1988.

    PubMed

    Morgan, M V; Stonnill, A; Laslett, A M

    1992-06-01

    A sample of 1100 Royal Australian recruits were examined for dental caries in 1988. Socio-demographic data were also collected. The mean DMFT scores were 4.33, 6.85, and 8.87 teeth for the 15-19 year-olds, 20-24 year-olds, and 25-29 year-olds, respectively. Caries experience varied between the state of origin of recruitment with Victorian and Queensland subjects having the highest DMFT scores, and Tasmanian subjects, the lowest. Comparison with previous military studies indicated not only a decreased dental caries experience, but also that restoration of teeth rather than extraction is a more likely treatment outcome of dental caries in recent recruits.

  20. Cutaneous leishmaniasis in Royal Marines from Oruzgan, Afghanistan.

    PubMed

    Matheson, A; Williams, R; Bailey, M S

    2012-09-01

    Leishmaniasis is an infectious disease caused by Leishmania protozoa and occurs as a spectrum of clinical syndromes ranging from various forms of cutaneous leishmaniasis (CL) to mucosal leishmaniasis (ML) and visceral leishmaniasis (VL). CL in Afghanistan is either zoonotic (ZCL) due to L. major or anthroponotic (ACL) due to L. tropica and there has been a prolonged epidemic of ACL in eastern Afghanistan since 1987. However, there have been remarkably few reports of CL due to L. tropica amongst foreign troops serving in Afghanistan since 2001. We describe two such cases in Royal Marines deployed to Oruzgan Province in Afghanistan from 2008-9. These patients illustrate important issues regarding the clinical features, referral, diagnosis, treatment and epidemiology of CL amongst foreign troops in Afghanistan. This disease has the potential to cause significant disruption to military personnel and units and so requires efficient management in order to maintain operational effectiveness.

  1. Royal dynasties as human inbreeding laboratories: the Habsburgs

    PubMed Central

    Ceballos, F C; Álvarez, G

    2013-01-01

    The European royal dynasties of the Early Modern Age provide a useful framework for human inbreeding research. In this article, consanguineous marriage, inbreeding depression and the purging of deleterious alleles within a consanguineous population are investigated in the Habsburgs, a royal dynasty with a long history of consanguinity over generations. Genealogical information from a number of historical sources was used to compute kinship and inbreeding coefficients for the Habsburgs. The marriages contracted by the Habsburgs from 1450 to 1750 presented an extremely high mean kinship (0.0628±0.009), which was the result of the matrimonial policy conducted by the dynasty to establish political alliances through marriage. A strong inbreeding depression for both infant and child survival was detected in the progeny of 71 Habsburg marriages in the period 1450–1800. The inbreeding load for child survival experienced a pronounced decrease from 3.98±0.87 in the period 1450–1600 to 0.93±0.62 in the period 1600–1800, but temporal changes in the inbreeding depression for infant survival were not detected. Such a reduction of inbreeding depression for child survival in a relatively small number of generations could be caused by elimination of deleterious alleles of a large effect according with predictions from purging models. The differential purging of the infant and child inbreeding loads suggest that the genetic basis of inbreeding depression was probably very different for infant and child survival in the Habsburg lineage. Our findings provide empirical support that human inbreeding depression for some fitness components might be purged by selection within consanguineous populations. PMID:23572123

  2. Long-term breeding phenology shift in royal penguins

    PubMed Central

    Hindell, Mark A; Bradshaw, Corey J A; Brook, Barry W; Fordham, Damien A; Kerry, Knowles; Hull, Cindy; McMahon, Clive R

    2012-01-01

    The Earth's climate is undergoing rapid warming, unprecedented in recent times, which is driving shifts in the distribution and phenology of many plants and animals. Quantifying changes in breeding phenology is important for understanding how populations respond to these changes. While data on shifts in phenology are common for Northern Hemisphere species (especially birds), there is a dearth of evidence from the Southern Hemisphere, and even fewer data available from the marine environment. Surface air temperatures at Macquarie Island have increased by 0.62°C during the 30-year study period (0.21°C decade−1) and royal penguins (Eudyptes schlegeli) commenced egg laying on average three days earlier in the 1990s than during the 1960s. This contrasts with other studies of Southern Ocean seabirds; five of nine species are now breeding on average 2.1 days later than during the 1950s. Despite the different direction of these trends, they can be explained by a single underlying mechanism: resource availability. There was a negative relationship between the Southern Annular Mode (SAM) and median laying date of royal penguins, such that low-productivity (low SAM) years delayed laying date. This accords with the observations of other seabird species from the Antarctic, where later laying dates were associated with lower sea ice and lower spring productivity. The unifying factor underpinning phenological trends in eastern Antarctica is therefore resource availability; as food becomes scarcer, birds breed later. These changes are not uniform across the region, however, with resource increases in the subantarctic and decreases in eastern Antarctica. PMID:22957162

  3. Fibrous osteodystrophy in two Northern Royal albatross chicks (Diomedea sanfordi).

    PubMed

    Morgan, K J; Alley, M R; Gartrell, B D; Thompson, K G; Perriman, L

    2011-09-01

    In February 2004, two Northern Royal albatross chicks aged 20 and 25 days old were presented for necropsy. Both chicks had been hand-fed in situ at a breeding colony, from 2-3 days post-hatch. The hand-rearing diet consisted of boneless hoki fillets (Macraronus novaezelandiae), electrolytes, and sooty shearwater (Puffinus griseus) proventricular oil obtained as a by-product of cultural harvest. Routine necropsies on the affected chicks revealed many bones were soft and easily bent. Radiography and histopathology revealed decreased bone density, pathological fractures, and extensive remodelling suggestive of fibrous osteodystrophy. Nutritional secondary hyperparathyroidism, resulting from an imbalance in the dietary Ca:P ratio. The imbalance in the dietary Ca:P ratio was a result of feeding deboned and eviscerated fish. This investigation also highlighted potential health risks associated with the practice of feeding stored rancid proventricular oil, including the destruction of fat-soluble vitamins. It is therefore possible that oxidative degradation of vitamin D may have contributed to the development of nutritional secondary hyperparathyroidism. Subsequently, dietary recommendations for supplementary feeding of orphaned Northern Royal albatross chicks include the feeding of whole human-grade fish with an appropriate Ca:P ratio, and the exclusion of proventricular oil. These cases highlight the need for scientific input into wildlife conservation projects, as lack of appropriate nutritional advice resulted in the feeding of a nutritionally inadequate diet. Following the recommended changes in diet, no further cases of osteodystrophy have been diagnosed in hand-raised chicks in the albatross colony.

  4. Long-term breeding phenology shift in royal penguins.

    PubMed

    Hindell, Mark A; Bradshaw, Corey J A; Brook, Barry W; Fordham, Damien A; Kerry, Knowles; Hull, Cindy; McMahon, Clive R

    2012-07-01

    The Earth's climate is undergoing rapid warming, unprecedented in recent times, which is driving shifts in the distribution and phenology of many plants and animals. Quantifying changes in breeding phenology is important for understanding how populations respond to these changes. While data on shifts in phenology are common for Northern Hemisphere species (especially birds), there is a dearth of evidence from the Southern Hemisphere, and even fewer data available from the marine environment. Surface air temperatures at Macquarie Island have increased by 0.62°C during the 30-year study period (0.21°C decade(-1)) and royal penguins (Eudyptes schlegeli) commenced egg laying on average three days earlier in the 1990s than during the 1960s. This contrasts with other studies of Southern Ocean seabirds; five of nine species are now breeding on average 2.1 days later than during the 1950s. Despite the different direction of these trends, they can be explained by a single underlying mechanism: resource availability. There was a negative relationship between the Southern Annular Mode (SAM) and median laying date of royal penguins, such that low-productivity (low SAM) years delayed laying date. This accords with the observations of other seabird species from the Antarctic, where later laying dates were associated with lower sea ice and lower spring productivity. The unifying factor underpinning phenological trends in eastern Antarctica is therefore resource availability; as food becomes scarcer, birds breed later. These changes are not uniform across the region, however, with resource increases in the subantarctic and decreases in eastern Antarctica.

  5. Changes in Curricula and Institutional Structures.

    ERIC Educational Resources Information Center

    Bollerslev, Peter; Estes, Nolan

    Prepared for a 1984 Organisation for Economic Cooperation and Development (OECD) conference, this report analyzes trends and changes in elementary, secondary, higher, and distance education curricula and institutional structures on the basis of a number of case studies from Australia, Belgium, Canada, Denmark, Japan, New Zealand, the Netherlands,…

  6. Medical education in The Netherlands.

    PubMed

    Ten Cate, Olle

    2007-10-01

    This paper aims to draw a picture of current medical education in The Netherlands. Based on strong historical roots in the seventeenth century, Dutch medical education has adapted to changing circumstances through the ages. Nowadays, medical education in The Netherlands may be called "modern", according to international standards and schools such as the one in Maastricht serve as examples, nationally and internationally. After considerable redesign of undergraduate education in the 1980s and 1990s, the first decade of the new century shows a revolutionary development of postgraduate medical education, with the introduction of nationwide competency-based training, and mandatory in-training assessments and portfolios for residents. The high level of activity in medical education development is reflected in high research productivity, measured as Dutch articles in international journals. Despite these strengths, several critical issues around medical education are in debate, ranging from entrance selection, small group tutoring, the two-cycle bachelor-master model and the relevance of basic sciences to the planning of enrolment numbers and working hours for residents. Medical education in The Netherlands is a dynamic field.

  7. Xenotransplantation: perspectives from The Netherlands.

    PubMed

    van Rongen, E

    1998-12-30

    Recently, the Health Council of the Netherlands published a report on xenotransplantation. The technique is considered ethically acceptable, both from a human and from an animal point of view. Clinical application should not yet be permitted, however, because of continuing rejection problems and growing concerns on safety aspects associated with possible transfer of pathogens from the xenotransplant to the host. More research is necessary. Mainly because of the risk for infection, nonhuman primates are not considered acceptable as source animals; the genetically engineered pig is at present the source animal of choice. Legally, import in the Netherlands of (organs from) source animals from within Europe is difficult to prevent. Therefore experiments with such material are not subjected to licensing by the government, which is the case for experiments involving genetic engineering with animals in the Netherlands, but only by local review boards. This situation is considered unwanted and adjustment of the pertinent law is suggested. Also, both genetically engineered animals and patients carrying organs from such animals fall under the European Genetically Modified Organisms regulations. These regulations are not designed for this case and conflicts may arise. Agreements on how to handle this situation have to be made at the European level. It is proposed to draft a national law on "biologicals," medical products consisting at least partly of living materials. Pending such regulations, it is suggested, also on a European level, that xenotransplants be considered as medicines, which would allow adequate control of safety aspects.

  8. Emergency departments in The Netherlands.

    PubMed

    Thijssen, Wendy A M H; Giesen, Paul H J; Wensing, Michel

    2012-01-01

    Emergency medicine in The Netherlands is faced with an increasing interest by politicians and stakeholders in health care. This is due to crowding, increasing costs, criticism of the quality of emergency care, restructuring of out-of-hours services in primary care and the introduction of a training programme for emergency physicians in 2000. A comprehensive search was conducted of published research, policy reports and updated Dutch websites on acute care. Publications were included in this review if these referred to emergency care, including emergency departments (ED), general practitioner (GP) cooperatives and emergency medical services in The Netherlands and were written in English or Dutch. The literature search identified 14 eligible papers. The manual search identified 11 additional papers. Seven reports and two PhD theses were also included. Given the lack of relevant empirical research the review was liberal in its inclusion, but the analysis focused on research when available. ED in The Netherlands are in different stages of development. However, it is obvious that the presence of emergency physicians is increasing and more ED will be staffed by emergency physicians. Although this seems an important step, it does not necessarily imply a good position of the emergency physician in the ED. What the characteristics of the future patient of the Dutch ED will be is dependent on the development of different ED levels of care and GP cooperatives. The lack of empirical research also points out the need for research on quality of care in Dutch ED.

  9. Study in the Netherlands: Small Countries Have To Be Smarter. General Edition.

    ERIC Educational Resources Information Center

    Netherlands Organisation for International Cooperation in Higher Education, The Hague.

    This booklet describes opportunities for higher education study in the Netherlands along with information, addresses, and practical tips for foreign students who are considering taking a course or earning a degree at a Dutch institution of higher education. Six sections cover: (1) the rewards of the investment in study abroad; (2) background on…

  10. Poster Session Presentation [from the Netherlands] [and] Seen at Close Quarters.

    ERIC Educational Resources Information Center

    Bergers, Ton

    Two papers examine vocational training, special education, and government services for the disabled in the Netherlands. Originally presented at a convention poster session of the 16th World Congress of Rehabilitation International, the first paper focuses on the national institute at Werkenrode which provides a residential practice-based education…

  11. Training in the Retail Trade in the Netherlands. Report for the FORCE Programme. First Edition.

    ERIC Educational Resources Information Center

    van den Tillaart, Harry

    An international team of researchers studied the following aspects of training in the Netherlands' retail sector: structure and characteristics, institutional and social context, employment and labor, changing conditions and their implications for skill requirements, and training and recruitment. Data were collected from an analysis of social and…

  12. Pre-service Teachers' Beliefs about Inclusive Education in the Netherlands: In Exploratory Study

    ERIC Educational Resources Information Center

    Civitillo, Sauro; De Moor, Jan M. H.; Vervloed, Mathijs P. J.

    2016-01-01

    Teachers' beliefs are crucial to the success of inclusion programmes and reform efforts for children with special educational needs (SEN). Based on this evidence, one hundred and thirty-nine primary pre-service teachers from one training institution in the Netherlands completed an adapted version of a measure of beliefs towards inclusive…

  13. Poster Session Presentation [from the Netherlands] [and] Seen at Close Quarters.

    ERIC Educational Resources Information Center

    Bergers, Ton

    Two papers examine vocational training, special education, and government services for the disabled in the Netherlands. Originally presented at a convention poster session of the 16th World Congress of Rehabilitation International, the first paper focuses on the national institute at Werkenrode which provides a residential practice-based education…

  14. Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila

    USDA-ARS?s Scientific Manuscript database

    The major royal-jelly proteins (MRJPs) are the main constituents responsible for the specific physiological role of royal jelly (RJ) in honeybees. Male and female Drosophila flies were fed diets containing either no MRJPs (A) or casein (B) at 1.25% (w/w) of diet or MRJPs at 1.25% (C), 2.50% (D), or ...

  15. The Relationship Between Soils and Foliar Nutrition For Planted Royal Paulownia

    Treesearch

    James E. Johnson; David O. Mitchem; Richard E. Kreh

    2002-01-01

    Royal paulownia is becoming an important hardwood plantation species in the southern U.S. A study was done to investigate two novel site preparation techniques for aiding the establishment of royal paulownia seedlings in the Virginia Piedmont. The effects of these treatments on the foliar nutrition of first year seedlings was determined, as was the relationship...

  16. The portrait of Dr William Harvey in the Royal Society since 1683.

    PubMed

    Keynes, Milo

    2006-09-22

    A portrait of William Harvey in the Royal Society since 1683 is a copy by an unknown artist after a portrait, now lost, painted by Sir Peter Lely ca. 1650. Three other unattributed copies besides a copy bought from Lely's studio on his death by the Earl of Bradford have been located. The present labelling of the Royal Society portrait should be corrected.

  17. [The combining ability and heterosis analysis of royal jelly yield and quality properties in western honeybees].

    PubMed

    Liu, Y H; Chen, S L; Zhong, B X

    2001-01-01

    The NC II mating design of 2 x 4 was made in order to evaluate The combining ability and heterosis of royal jelly yield and quality properties that included royal jelly yield, royal jelly yield per cup, acceptance ratio and acidity in Apis mellifera. The results were as follows: (1) For all characters, general combining ability in six parents (GCA) achieved highly significant level (P < 0.01), special combining ability (SCA) only significant (P < 0.05), therefore the additive effect is more important for royal jelly yield and quality properties; (2) The GCA of A. m. acervorum in four characters was higher, and the SCA variance of A. m. carpatica, A. m. caucasica was greater, so they were good parents. ZND-1 Apis mellifera lingustica in royal jelly yield, royal jelly yield per cup, acceptance ratio was an excellent parent, but A. m. carnica only could be used in increasing royal jelly quality; (3) The heterosis over high-parent is negative, thus it is difficult to improve royal jelly yield and quality by cross breeding, but by appropriate choice of parents, high yield and quality combination can be obtained.

  18. Response of Planted Royal Paulownia to Weed Control Treatments After Coppice

    Treesearch

    David O. Mitchem; James E. Johnson; Richard E. Kreh

    2002-01-01

    Today there is an increased interest in growing royal paulownia (Paulownia tomentosa) in the southeastern United States, but difficulties have been encountered in the Piedmont due to heavy clays and intense competition for moisture. Two royal paulownia plantations were established on the Virginia Piedmont to evaluate the effects that weedmats have on...

  19. 78 FR 42512 - Application to Export Electric Energy; Royal Bank of Canada

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... Application to Export Electric Energy; Royal Bank of Canada AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Royal Bank of Canada (RBC) has applied to renew its authority to transmit electric energy from the United States to Canada pursuant to section 202(e) of...

  20. Flamsteed's stars. New perspectives on the life and work of the first Astronomer Royal (1646 - 1719).

    NASA Astrophysics Data System (ADS)

    Willmoth, F.

    Contents: 1. Introduction: the King's "astronomical observer". 2. Flamsteed's career in astronomy: nobility, morality and public utility (J. Bennett). 3. Astronomy and strife: John Flamsteed and the Royal Society (M. Feingold). 4. Models for the practice of astronomy: Flamsteed, Horrocks and Tycho (F. Willmoth). 5. Flamsteed's optics and the identity of the astronomical observer (A. Johns). 6. Equipping an observatory: Flamsteed and Molyneux discuss an astronomical quadrant (H. Higton). 7. Mathematical characters: Flamsteed and Christ's Hospital Royal Mathematical School (R. Iliffe). 8. "Professor" John Flamsteed (I. G. Stewart). 9. Edmond Halley and John Flamsteed at the Royal Observatory (A. Cook). 10. A unique copy of Flamsteed's Historia coelestis (1712) (O. Gingerich). 11. "Labour harder than thrashing": John Flamsteed, property and intellectual labour in nineteenth-century England (W. J. Ashworth). 12. The Flamsteed papers in the archives of the Royal Greenwich Observatory. (A. Perkins). A summary catalogue of Flamsteed's papers in the Royal Greenwich Observatory archives (compiled by F. Willmoth).

  1. Gradual Retirement in the Netherlands: An Analysis Using Administrative Data.

    PubMed

    Bloemen, Hans; Hochguertel, Stefan; Zweerink, Jochem

    2016-02-01

    Gradual retirement by which individuals leave their career jobs and withdraw incrementally from the labor force is an important empirical phenomenon in the United States. We analyze the current state of gradual retirement in the Netherlands using administrative data that allow much more precise tracking of labor market transitions than most survey panel data. We estimate multinomial transition models, taking into account competing pathways out of career employment at older ages, and discuss institutional aspects that limit the scope of gradual retirement, such as financial incentives to retire early.

  2. Monitoring the Solar Radius from the Royal Observatory of the Spanish Navy since 1773

    NASA Astrophysics Data System (ADS)

    Vaquero, J. M.; Gallego, M. C.; Ruiz-Lorenzo, J. J.; López-Moratalla, T.; Carrasco, V. M. S.; Aparicio, A. J. P.; González-González, F. J.; Hernández-García, E.

    2016-08-01

    The solar diameter has been monitored at the Royal Observatory of the Spanish Navy (today the Real Instituto y Observatorio de la Armada: ROA) almost continuously since its creation in 1753 ( i.e. during the past 250 years). After a painstaking effort to collect data in the historical archive of this institution, we present here the data of the solar semidiameter from 1773 to 2006, making up an extensive new database for solar-radius measurements, which can be considered. We have calculated the solar semidiameter from the transit times registered by the observers (except for values of the solar radius from the modern Danjon astrolabe, which were published by ROA). These data were analysed to reveal any significant long-term trends, but no such trends were found. Therefore, the data sample confirms the constancy of the solar diameter during the past 250 years (approximately) within instrumental and methodological limits. Moreover, no relationship between solar radius and the new sunspot-number index has been found from measurements of the ROA. Finally, the mean value for the solar semidiameter (with one standard deviation) calculated from the observations made in the ROA (1773 - 2006), after applying corrections for refraction and diffraction, is equal to 958.87^''±1.77^''.

  3. Protective Effect of Royal Jelly on In Vitro Fertilization (IVF) in Male Mice Treated with Oxymetholone

    PubMed Central

    Zahmatkesh, Ensieh; Najafi, Gholamreza; Nejati, Vahid

    2015-01-01

    Objective This study aimed to investigate the effects of royal jelly (RJ) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (OXM). Materials and Methods In this exprimental study, 32 male and 96 female adult Naval Medical Research Institute (NMRI) mice (7-9 weeks of age) with a ratio of 1:3 for fertili- zation purposes were randomly divided into 4 groups as follows: i. Control group (n=8) receiving 0.1 ml/mice saline daily by gavage for 30 day, ii. RJ group (n=8) treated with RJ at a dose of 100 mg/kg daily by gavage for 30 days, iii. OXM group (n=8) receiving OXM at the dose of 5 mg/kg daily by gavage for 30 days and iv. RJ+OXM group (n=8) receiving RJ at the dose of 100 mg/kg daily by gavage concomitant with 100 mg/kg OXM adminis- tration for 30 days. Results Analysis revealed a significant reduction in catalase, total antioxidant, as well as embryo development in OXM group (P<0.05). However, RJ group showed a salient recovery in the all of the above mentioned parameters and embryo toxicity. Conclusion The results of this study indicated a partially protective effect of RJ against OXM-induced embryo toxicity. PMID:26464831

  4. New clinical trials regulation in Spain: analysis of royal decree 1090/2015.

    PubMed

    Martin Jimenez, M; Calvo Ferrandiz, A; Aparicio Urtasun, J; Garcia-Campelo, R; Gonzalez-Flores, E; Lazaro Quintela, M; Muñoz Mateu, M; Rodriguez Sanchez, C A; Santaballa Bertran, A; Sepulveda Sanchez, J M; Vera Garcia, R; Virizuela Echaburu, J A; Segui Palmer, M A

    2017-03-01

    The coming into force of Directive 2001/20/EC represented a step forward in harmonising clinical trial regulation in European countries, guaranteeing a uniform protection of subjects participating in clinical research across Europe. However, it led to a disproportionate increase in the bureaucratization, and thus, it became evident that procedures needed to be simplified without detriment to patient's safety. Thus, Regulation 536/2014, that repealed Directive 2001/20/EC, with the aim of decreasing the growing bureaucratization and stimulating clinical research in Europe, established simplified procedures, such as regulating a common procedure for authorising trials in Europe, the institution of strict assessment timelines, or the definition of new concepts, such as "low-intervention clinical trial". The legal form of a Regulation allowed the norm to be directly applied to Member States without the need for transposition. By means of the new Royal Decree, the national legislation is adapted to make the application of the regulation feasible and it allows the development of the aspects that the Regulation leaves to national legislation. Both documents seek to stimulate clinical research with medicinal products to foster knowledge, facilitate transparency, and reinforce subjects' safety. This will surely be the case, but with this revision, we will look at the novelties and key aspects that are most relevant to investigators and we will analyse the consequences for all parties involved in clinical research.

  5. BOOK REVIEW: Robert Hooke and the Royal Society

    NASA Astrophysics Data System (ADS)

    Brown, Neil

    2000-01-01

    Many physics students only come across Hooke when they learn his law of stretching springs, which is a pity because it is just one of his contributions to progress in science, and a minor one at that. His, Micrographia, the first great book of microscopical observations, arouses admiration to this day. He was also active in horology, astronomy, geology and surveying, and he took part in biological experiments, transfusing blood between animals. Much of his work was done while he was curator of experiments for the Royal Society, in which he was involved almost from its foundation. This was by no means a full-time occupation, however. After the Great Fire of London, Hooke was appointed one of the three surveyors for the rebuilding of the city. One of the others was Christopher Wren, a lifelong friend. In this role Hooke was responsible for the design of several buildings, including the Monument. Nichols writes about all these activities, as well as Hooke's childhood, his education at Westminster School, the University of Oxford when Hooke was an undergraduate, and the founding of the Royal Society. The book draws on research for a master's degree. Turning a dissertation into a popular book is risky. The author has avoided the pitfall of making it too academic, but the result is not satisfying. Nichols seems overawed by Hooke and his work, frequently seeming to credit Hooke with a far-reaching influence that he did not necessarily have. There may be a case for lauding Hooke as the father of English microscopy, the father of English meteorology, and the founder of English geology and earth sciences, but it needs to be made much more critically, even in a popular work. Hooke was full of good ideas, but he rarely continued long enough to put them into practice. There is no doubt that Hooke proposed using a balance wheel and spring to improve the timekeeping of a watch, for example, but he did not have a watch made to his design until after Christiaan Huygens had

  6. Predicting neck pain in Royal Australian Air Force fighter pilots.

    PubMed

    Tucker, Bennett; Netto, Kevin; Hampson, Gregory; Oppermann, Brett; Aisbett, Brad

    2012-04-01

    Fighter pilots frequently report neck pain and injury, and although risk factors have been suggested, the relationships between risk factors and neck pain have not been quantified. The aim of this study was to identify personal and work behaviors that are significantly associated with neck pain in fighter pilots. Eighty-two Royal Australian Air Force fighter pilots were surveyed about their flying experience, neck pain prevalence, and prevention. Multinomial logistic regressions were used to fit models between pilots' neck pain during and after flight and a range of personal and work characteristics. In-flight neck pain was very weakly, yet positively associated with flight hours. Duration of postflight pain was positively associated with the weekly desktop work hours and the sum of preventative actions taken in flight. The duration pilots were considered temporarily medically unfit for flying was positively associated with pilots' age and their weekly desktop work hours. The risk factors identified by the current study should guide neck pain prevention for fighter pilots. In particular, reducing desktop working hours as well as incorporating specific neck-strengthening exercises and in-flight bracing actions should be considered by agencies to help alleviating neck pain in their pilots.

  7. Genetic royal cheats in leaf-cutting ant societies

    PubMed Central

    Hughes, William O. H.; Boomsma, Jacobus J.

    2008-01-01

    Social groups are vulnerable to cheating because the reproductive interests of group members are rarely identical. All cooperative systems are therefore predicted to involve a mix of cooperative and cheating genotypes, with the frequency of the latter being constrained by the suppressive abilities of the former. The most significant potential conflict in social insect colonies is over which individuals become reproductive queens rather than sterile workers. This reproductive division of labor is a defining characteristic of eusocial societies, but individual larvae will maximize their fitness by becoming queens whereas their nestmates will generally maximize fitness by forcing larvae to become workers. However, evolutionary constraints are thought to prevent cheating by removing genetic variation in caste propensity. Here, we show that one-fifth of leaf-cutting ant patrilines cheat their nestmates by biasing their larval development toward becoming queens rather than workers. Two distinct mechanisms appear to be involved, one most probably involving a general tendency to become a larger adult and the other relating specifically to the queen–worker developmental switch. Just as evolutionary theory predicts, these “royal” genotypes are rare both in the population and within individual colonies. The rarity of royal cheats is best explained as an evolutionary strategy to avoid suppression by cooperative genotypes, the efficiency of which is frequency-dependent. The results demonstrate that cheating can be widespread in even the most cooperative of societies and illustrate that identical principles govern social evolution in highly diverse systems. PMID:18339809

  8. Physical fitness and anthropometric characteristics of Royal Thai Army personnel.

    PubMed

    Napradit, Phunphen; Pantaewan, Pannee

    2009-02-01

    The objective of the present study was to determine the relationship between physical fitness and anthropometric characteristics in Royal Thai Army (RTA) personnel. Body weight, height, waist circumference, hip circumference and blood pressure were measured. Body mass index (BMI) and waist-hip ratio (WHR) were calculated. Subsequently, 4,030 males aged 20 to 60 years were field tested using 2-minute push ups/sit-ups and 2-kilometer run to measure muscular strength/endurance and cardiorespiratory endurance, respectively. Data were analyzed for the relationships between BMI and anthropometric variables and blood pressure and physical fitness results. The average BMI for RTA personnel was 24.0 +/- 3.3 kg/m2. Correlation coefficient between BMI and waist circumference (r = 0.847, p < 0.001) was better than BMI and WHR (r = 0.553, p < 0.001). Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) had a significant positive correlation with BMI. The numbers of push-ups/sit-ups had a negative correlation with BMI (r = -0.121 and -0.109, respectively), whereas 2-kilometer run times had a positive correlation with BMI (r = 0.291, p < 0.001). In conclusion, RTA personnel with increasing BMI tend to have low physical fitness level.

  9. Nitrogen mineralization in a mature boreal forest, Isle Royale, Michigan

    USGS Publications Warehouse

    Stottlemyer, R.; Toczydlowski, D.

    1999-01-01

    The 115-ha boreal Wallace Lake watershed, located on Isle Royale in the Lake Superior Basin, receives moderate anthropogenic atmospheric N inputs (3 kg ha-1 yr-1). Ecosystem response to atmospheric N inputs is, in part, determined by internal production and consumption of this limiting nutrient. The objectives of this 2-yr study on plots dominated by birch, spruce, or alder were to quantify forest floor and surface soil net and gross N mineralization rates, and examine potential effects of changes in temperature and moisture on these processes. Gross N mineralization rates were 23 times net mineralization rates, and increased with forest floor/soil temperature and moisture. Substrate quality was a likely factor in higher gross mineralization rates beneath birch and spruce. Ammonium immobilization increased with forest floor/soil temperature and moisture. Higher net N mineralization rates beneath alder resulted from lower microbial immobilization rather than greater gross N mineralization. The greatest differences between gross N mineralization and immobilization occurred in early summer. Ammonium immobilization averaged 62% of gross N mineralization. Net and gross nitrification rates differed by vegetation type, were highest in spring and fall, and increased with moisture. Gross nitrification was 19 times net nitrification rates. Nitrate immobilization increased with soil moisture, and equalled or exceeded gross nitrification. Net and gross N mineralization or nitrification rates were not correlated. Seasonal variation in forest floor and surface soil N cycling coupled with high ecosystem retention of precipitation N inputs suggest streamwater N concentrations and output reflect trends in soil processes.

  10. Experiences of New Faculty in a Transitional Institution

    ERIC Educational Resources Information Center

    Yeo, Michelle; Bennett, Deb; Merkley, Cari; McNichol, Jane; Osakwe, Carlton; Pada, Carolyn

    2010-01-01

    This research project studies the induction and socialization of new faculty at Mount Royal University, recently transitioned from college to undergraduate university status. There is extensive documentation in the literature on issues faced by new faculty in post-secondary institutions; however, very little is published on how a culture in flux…

  11. [Two cases of royal jelly allergy provoked the symptoms at the time of their first intake].

    PubMed

    Harada, Susumu; Moriyama, Tatsuya; Tanaka, Akira

    2011-06-01

    Two young women were suffered from several symptoms after the intake of royal jelly at their first time. According to the positive skin prick test reactions of raw royal jelly, royal jelly allergy was diagnosed. As the reasons why the symptoms appeared at the time of their first intake, we guessed the possibility that 1) they had been sensitized for royal jelly formerly, or 2) their symptoms were induced by the cross-reactivity between royal jelly and other allergens such as bee, honey and pollens. As to our cases, no related allergens were found in one case, but in another case co-existence of mugwort allergy was suspected from the results of both skin prick test and specific IgE titers. Originally royal jelly allergy has been regarded as class 1 allergic reaction developed by the sensitization of itself. But we speculated the possibility that there can also be cases of class 2 royal jelly allergy by the mechanism of cross-reaction with pollens.

  12. Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus.

    PubMed

    Miyashita, Atsushi; Kizaki, Hayato; Sekimizu, Kazuhisa; Kaito, Chikara

    2016-06-15

    Honeybee royal jelly is reported to have body-enlarging effects in holometabolous insects such as the honeybee, fly and silkmoth, but its effect in non-holometabolous insect species has not yet been examined. The present study confirmed the body-enlarging effect in silkmoths fed an artificial diet instead of mulberry leaves used in the previous literature. Administration of honeybee royal jelly to silkmoth from early larval stage increased the size of female pupae and adult moths, but not larvae (at the late larval stage) or male pupae. We further examined the body-enlarging effect of royal jelly in a non-holometabolous species, the two-spotted cricket Gryllus bimaculatus, which belongs to the evolutionarily primitive group Polyneoptera. Administration of royal jelly to G. bimaculatus from its early nymph stage enlarged both males and females at the mid-nymph and adult stages. In the cricket, the body parts were uniformly enlarged in both males and females; whereas the enlarged female silkmoths had swollen abdomens. Administration of royal jelly increased the number, but not the size, of eggs loaded in the abdomen of silkmoth females. In addition, fat body cells were enlarged by royal jelly in the silkmoth, but not in the cricket. These findings suggest that the body-enlarging effect of royal jelly is common in non-holometabolous species, G. bimaculatus, but it acts in a different manner than in holometabolous species.

  13. Body-enlarging effect of royal jelly in a non-holometabolous insect species, Gryllus bimaculatus

    PubMed Central

    Miyashita, Atsushi; Kizaki, Hayato; Sekimizu, Kazuhisa; Kaito, Chikara

    2016-01-01

    ABSTRACT Honeybee royal jelly is reported to have body-enlarging effects in holometabolous insects such as the honeybee, fly and silkmoth, but its effect in non-holometabolous insect species has not yet been examined. The present study confirmed the body-enlarging effect in silkmoths fed an artificial diet instead of mulberry leaves used in the previous literature. Administration of honeybee royal jelly to silkmoth from early larval stage increased the size of female pupae and adult moths, but not larvae (at the late larval stage) or male pupae. We further examined the body-enlarging effect of royal jelly in a non-holometabolous species, the two-spotted cricket Gryllus bimaculatus, which belongs to the evolutionarily primitive group Polyneoptera. Administration of royal jelly to G. bimaculatus from its early nymph stage enlarged both males and females at the mid-nymph and adult stages. In the cricket, the body parts were uniformly enlarged in both males and females; whereas the enlarged female silkmoths had swollen abdomens. Administration of royal jelly increased the number, but not the size, of eggs loaded in the abdomen of silkmoth females. In addition, fat body cells were enlarged by royal jelly in the silkmoth, but not in the cricket. These findings suggest that the body-enlarging effect of royal jelly is common in non-holometabolous species, G. bimaculatus, but it acts in a different manner than in holometabolous species. PMID:27185266

  14. Compact Geography of the Netherlands. Fifth Edition.

    ERIC Educational Resources Information Center

    Meijer, H.

    A short, concise summary of the geography of the Netherlands is presented in this document. The introduction describes the country's governmental forms, physical location, provinces, population, and history. Geographic coverage includes: (1) the high and low Netherlands; (2) the struggle against flooding and land reclamation; (3) the polders, or…

  15. Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats

    PubMed Central

    Malekinejad, Hassan; Ahsan, Sima; Delkhosh-Kasmaie, Fatemeh; Cheraghi, Hadi; Rezaei-Golmisheh, Ali; Janbaz-Acyabar, Hamed

    2016-01-01

    Objective(s): Paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. The cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages. Materials and Methods: Adult male Wistar rats were divided into control and test groups (n=8). The test group was assigned into five subgroups; 4 groups, along with paclitaxel administration (7.5 mg/kg BW, weekly), received various doses of royal jelly (50, 100, and 150 mg/kg BW) for 28 consecutive days. The last group received only royal jelly at 100 mg/kg. In addition to oxidative and nitrosative stress biomarkers, the creatine kinase (CK-BM) level was also determined. To show the cardioprotective effect of royal jelly on paclitaxel-induced damages, histopathological examinations were conducted. Results: Royal jelly lowered the paclitaxel-elevated malondialdehyde and nitric oxide levels in the heart. Royal jelly could also remarkably reduce the paclitaxel-induced cardiac biomarker of creatine kinase (CK-BM) level and pathological injuries such as diffused edema, hemorrhage, congestion, hyaline exudates, and necrosis. Moreover, royal jelly administration in a dose-dependent manner resulted in a significant (P<0.05) increase in the paclitaxel-reduced total antioxidant capacity. Conclusion: Our data suggest that the paclitaxel-induced histopathological and biochemical alterations could be protected by the royal jelly administration. The cardioprotective effect of royal jelly may be related to the suppression of oxidative and nitrosative stress. PMID:27081469

  16. Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats

    PubMed Central

    Azab, Khaled Shaaban; Bashandy, Mohamed; Salem, Mahmoud; Ahmed, Osama; Tawfik, Zaki; Helal, Hamed

    2011-01-01

    Background: Royal jelly is a nutritive secretion produced by the worker bees, rich in proteins, carbohydrates, vitamins and minerals. Aim: The present study was designed to determine the possible protective effects of royal jelly against radiation induced oxidative stress, hematological, biochemical and histological alterations in male Wister albino rats. Materials and Methods: Male Wister albino rats were exposed to a fractionated dose of gamma radiation (2 Gy every 3 days up to 8 Gy total doses). Royal jelly was administrated (g/Kg/day) by gavages 14 days before exposure to the 1st radiation fraction and the treatment was continued for 15 days after the 1st irradiation fraction till the end of the experiment. The rats were sacrificed 3rd, equivalent to 3rd post 2nd irradiation fraction, and equivalent to 3rd day post last irradiation fraction. Results: In the present study, gamma- irradiation induced hematological, biochemical and histological effects in male Wister albino rats. In royal jelly treated irradiated group, there was a noticeable decrease recorded in thiobarbituric reactive substances concentration when compared to γ-irradiated group. Also, the serum nitric oxide concentration was significantly improved. The administration of royal jelly to irradiated rats according to the current experimental design significantly ameliorates the changes induced in serum lipid profile. Moreover, in royal jelly treated irradiated group, there was a noticeable amelioration recorded in all hematological parameters along the three experimental intervals. The microscopic examination of cardiac muscle of royal jelly treated irradiated rats demonstrated structural amelioration, improved nuclei and normal features of capillaries and veins in endomysium when compared to gamma-irradiated rats. Conclusion: It was suggested that the biochemical, hematological and histological amelioration observed in royal jelly (g/Kg/day) treated irradiated rats might be due to the antioxidant

  17. Comparative analyses of the major royal jelly protein gene cluster in three Apis species with long amplicon sequencing.

    PubMed

    Helbing, Sophie; Lattorff, H Michael G; Moritz, Robin F A; Buttstedt, Anja

    2017-06-01

    The western honeybee, Apis mellifera is a prominent model organism in the field of sociogenomics and a recent upgrade substantially improved annotations of the reference genome. Nevertheless, genome assemblies based on short-sequencing reads suffer from problems in regions comprising e.g. multi-copy genes. We used single-molecule nanopore-based sequencing with extensive read-lengths to reconstruct the organization of the major royal jelly protein (mrjp) region in three species of the genus Apis. Long-amplicon sequencing provides evidence for lineage-specific evolutionary fates of Apis mrjps. Whereas the most basal species, A. florea, seems to encode ten mrjps, different patterns of gene loss and retention were observed for A. mellifera and A. dorsata. Furthermore, we show that a previously reported pseudogene in A. mellifera, mrjp2-like, is an assembly artefact arising from short read sequencing. © The Author 2017. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  18. Traditional virtues, feudal ties and Royal Guards: the culture of service in the eighteenth-century "Maison Militaire du Roi".

    PubMed

    O'Brien, David C

    2003-01-01

    Recent discussions of French army reform before the Revolution have revived interest in the more general topic of military culture in the ancien régime. One account of this period speaks of an evolution in criteria for military merit, one in which professional efficiency came to overshadow traditional martial virtues, such as fidelity and courage. But a review of the evidence, both archival and published, from the Maison militaire du Roi reveals that here, at least, old virtues continued to be central until the end, serving as expressions of a relationship with the king in which royal grâces were their natural complement. Viewed historically, this conception of service continued a feudal tradition. The milieu of the Maison was distinctive in the encouragement it gave to such traditions, but the function of the institution as a pépinière of officers for the army gave it a potentially wide influence in balancing the tendencies towards professionalism.

  19. Proteomic characterization of royal jelly proteins in Chinese (Apis cerana cerana) and European (Apis mellifera) honeybees.

    PubMed

    Qu, Ning; Jiang, Jie; Sun, Liangxian; Lai, Changcheng; Sun, Lifang; Wu, Xueji

    2008-06-01

    In this study, the proteins contained in royal jelly (RJ) derived from Chinese and European honeybees have been analyzed in detail and compared. Remarkable differences were found in the heterogeneity of major royal jelly proteins (MRJPs), MRJP2 and MRJP3, in terms of molecular weight and isoelectric points between the two species of RJ. MRJP2 and MRJP3 produced by Chinese honeybee are less polymorphic than those produced by European honeybee. This study is a contribution to the description of the royal jelly proteome.

  20. Royal London space analysis: plaster versus digital model assessment.

    PubMed

    Grewal, Balpreet; Lee, Robert T; Zou, Lifong; Johal, Ama

    2017-06-01

    With the advent of digital study models, the importance of being able to evaluate space requirements becomes valuable to treatment planning and the justification for any required extraction pattern. This study was undertaken to compare the validity and reliability of the Royal London space analysis (RLSA) undertaken on plaster as compared with digital models. A pilot study (n = 5) was undertaken on plaster and digital models to evaluate the feasibility of digital space planning. This also helped to determine the sample size calculation and as a result, 30 sets of study models with specified inclusion criteria were selected. All five components of the RLSA, namely: crowding; depth of occlusal curve; arch expansion/contraction; incisor antero-posterior advancement and inclination (assessed from the pre-treatment lateral cephalogram) were accounted for in relation to both model types. The plaster models served as the gold standard. Intra-operator measurement error (reliability) was evaluated along with a direct comparison of the measured digital values (validity) with the plaster models. The measurement error or coefficient of repeatability was comparable for plaster and digital space analyses and ranged from 0.66 to 0.95mm. No difference was found between the space analysis performed in either the upper or lower dental arch. Hence, the null hypothesis was accepted. The digital model measurements were consistently larger, albeit by a relatively small amount, than the plaster models (0.35mm upper arch and 0.32mm lower arch). No difference was detected in the RLSA when performed using either plaster or digital models. Thus, digital space analysis provides a valid and reproducible alternative method in the new era of digital records.

  1. Royal Jelly Increases Collagen Production in Rat Skin After Ovariectomy

    PubMed Central

    Park, Hye Min; Cho, Min Hyoung; Cho, Yunhi

    2012-01-01

    Abstract Royal jelly (RJ) is a honeybee product that contains proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. RJ has been reported to have antitumor, antibacterial, and wound-healing activities. We previously reported that RJ enhanced the migration of human dermal fibroblasts and altered the levels of cholesterol and sphinganine in an in vitro wound-healing model in addition to regulating skin photoaging following exposure to ultraviolet-B radiation. We established an animal model of skin aging in the context of estrogen deficiency and assessed the antiaging effects of RJ on skin. To establish an in vivo model of skin aging, bilateral ovariectomies were performed in 12-week-old virgin female Sprague-Dawley rats. Induction of osteoporosis was confirmed through two-dimensional images of the trabecular bone in the left femoral necks using microcomputed tomography. The protective effects of RJ ovariectomy-induced skin aging were examined by determining the protein expression of type I procollagen and matrix metalloproteinase (MMP)-1. The collagen content and epidermal thickness of skin tissue were measured by staining techniques. There was a significant difference in weight between sham-operated and ovariectomized groups. Food efficiency ratio did not differ significantly among the groups. The level of procollagen type I protein was increased in the dorsal skin of ovariectomized rats fed with a dietary supplement containing 1% RJ extract, but the level of MMP-1 was not altered. In particular, the amount of collagen recovered was close to the normal level. RJ may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency. PMID:22468645

  2. Anaemia in elective orthopaedic surgery - Royal Adelaide Hospital, Australia.

    PubMed

    Kearney, B; To, J; Southam, K; Howie, D; To, B

    2016-01-01

    An anaemia clinic was established to improve the preoperative management of elective orthopaedic patients scheduled for arthroplasty. This paper is a report on the first 100 patients assessed. To assess the incidence and causes of anaemia in patients on a waiting list for elective arthroplasty in a public hospital and to assess the impact of anaemia detection in this patient population. Patients attending an Anaemia Clinic for elective orthopaedic surgical patients, during March 2010 to June 2013 were studied. Outcome measures included change in haemoglobin preoperative results and perioperative transfusion rates by preoperative haemoglobin. Seventeen per cent of patients scheduled for elective surgery were found to be anaemic. Of the 100 patients who attended, approximately half were found to be iron deficient and the remainder had anaemia of chronic disease. Serum ferritin <30 µg/L alone did not identify iron deficiency in 80% of patients with iron deficiency. Patients with iron deficient anaemia were able to be treated, in all cases, to achieve a significant increase in preoperative haemoglobin. The general unavailability of erythropoietin limited effective intervention for the non-iron-deficient anaemic patients. Seven patients had their surgery cancelled because of the screening programme. Half of the anaemic patients in a joint replacement screening clinic were iron deficient, and treatment was effective in improving the pre-operative haemoglobin and reducing perioperative transfusion rates. This screening process should improve patient outcome. Another important finding in this group of patients is that ferritin levels cannot be reliably used as the sole indicator in the diagnosis of iron deficiency anaemia in this group of patients undergoing elective arthroplasty. © 2015 Royal Australasian College of Physicians.

  3. CONFERENCE NOTE: International Workshop on Radiation Thermometry Noordwijkerhout, the Netherlands, 24 25 June 1993

    NASA Astrophysics Data System (ADS)

    1993-01-01

    Radiation thermometry is applied in the measurement of temperature where direct contact with the object is impossible, such as in the case of very high temperatures or moving bodies. Important industrial applications are metal, glass, ceramics and plastics and, latterly, semiconductor technology. Recent developments, such as multi-wavelength pyrometry, have motivated the Nederlands Meetinstituut and two Russian institutes, Energotechnica and Symco Association, to organize this workshop. Specialists from Russia, the USA, the UK, Germany and the Netherlands will present state-of-the-art practical applications in radiation thermometry. The workshop will be held on 24 and 25 June 1993 in the "Leeuwenhorst" Congress Centre, Noordwijkerhout, the Netherlands. Information on the technical contents of the programme can be obtained from Dr P Bloembergen, Tel. +31(15) 691 660. Registration For further details please contact: The Training and Consultancy Department, Nederlands Meetinstituut, PO Box 654, 2600 AR Delft, the Netherlands Tel. +31 (15) 691 567.

  4. Two cases of 16th century head injuries managed in royal European families.

    PubMed

    Dowling, Kamilah A; Goodrich, James Tait

    2016-07-01

    In Europe, during the 16th century, there were a number of prominent general surgeons adventurous enough to consider operating on the brain for head injuries. From the time of Hippocrates, operating on the skull and brain was considered both treacherous and too dangerous to be undertaken except on rare occasions. Operating on a member of a royal court was considered even more exceptional because if the outcome was poor, the surgeon could lose a hand or limb, or, even worse, be beheaded. The authors present two interesting cases of royal family members who underwent surgery for head injuries that were quite severe. The surgeons involved, Ambroise Paré, Andreas Vesalius, and Berengario da Carpi, were among the most prominent surgeons in Europe. Despite very challenging political situations, all were willing to undertake a complex surgical intervention on the member of a prominent royal family. The individuals involved, both royal and medical, plus the neurosurgical injuries are discussed.

  5. The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy.

    PubMed

    Erdem, Ozden; Güngörmüş, Zeynep

    2014-01-01

    This study was conducted to evaluate the effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. The study population consisted of 103 patients undergoing radiotherapy and chemotherapy. Oral mucositis was graded according to the World Health Organization criteria, and patients were divided into 2 groups. All patients received mouthwash therapy with benzydamine hydrochloride and nystatin rinses. In addition, patients in the experimental group received royal jelly. The mean resolution time of oral mucositis in the royal jelly group was significantly shorter than that of the control group. As a result, the study results demonstrate that royal jelly administrated by a certain procedure improved the signs and symptoms of oral mucositis and markedly shortened its healing time.

  6. Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression.

    PubMed

    Han, Sang Mi; Yeo, Joo Hong; Cho, Yoon Hee; Pak, Sok Cheon

    2011-01-01

    For cosmetic reasons, the demand for effective and safe skin-whitening agents is high. Since the key enzyme in the melanin synthetic pathway is tyrosinase, many depigmenting agents in the treatment of hyperpigmentation act as tyrosinase inhibitors. In this study, we have investigated the hypo-pigmentary mechanism of royal jelly in a mouse melanocyte cell line, B16F1. Treatment of B16F1 cells with royal jelly markedly inhibited melanin biosynthesis in a dose-dependent manner. Decreased melanin content occurred through the decrease of tyrosinase activity. The mRNA levels of tyrosinase were also reduced by royal jelly. These results suggest that royal jelly reduces melanin synthesis by down-regulation of tyrosinase mRNA transcription and serves as a new candidate in the design of new skin-whitening or therapeutic agents.

  7. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

    PubMed

    Spannhoff, Astrid; Kim, Yong Kee; Raynal, Noel J-M; Gharibyan, Vazganush; Su, Ming-Bo; Zhou, Yue-Yang; Li, Jia; Castellano, Sabrina; Sbardella, Gianluca; Issa, Jean-Pierre J; Bedford, Mark T

    2011-03-01

    Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly.

  8. Genetic variability among lake whitefish from Isle Royale and the Upper Great Lakes

    USGS Publications Warehouse

    Stott, Wendylee; Todd, Thomas N.; Kallemeyn, Larry

    2004-01-01

    The coregonine fishes from Isle Royale National Park represent a unique group that has escaped the successional changes observed elsewhere in North America. Analysis of microsatellite DNA loci revealed significant genetic differences among samples of lake whitefish (Coregonus clupeaformis) from Isle Royale, Lake Superior, and Lake Huron. The amount of genetic variation observed is consistent with that seen in other studies of whitefishes from North America. The lake whitefish from Isle Royale had previously been assigned sub-species status, but no evidence was found to support this. The effects of common ancestry and demographics both play a role in determining the relatedness of the populations. As with other fish species from Isle Royale and the upper Great Lakes, the lake whitefish have their origins in the Mississippi refugium.

  9. [Analysis of tetracyclines in honey and royal jelly by LC/MS/MS].

    PubMed

    Ishii, Rie; Horie, Masakazu; Murayama, Mitsunori; Maitani, Tamio

    2006-12-01

    A simple and accurate method using liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) was developed for the determination of tetracyclines (TCs), i.e., oxytetracycline (OTC), chlortetracycline (CTC) and tetracycline (TC), in honey and royal jelly. Mass spectral acquisition was performed in the positive mode. In LC separation, L-column ODS and 0.01% formic acid-acetonitrile were used as the column and mobile phase, respectively. TCs in a honey sample were diluted with water, while TCs in royal jelly were extracted with 2% metaphosphoric acid-methanol (6:4). They were cleaned up with Oasis HLB and Sep Pak C18 cartridges, respectively. The quantification limits of TC, OTC, and CTC were 5, 5, and 10 ng/g, respectively, while those in royal jelly were 25, 25, and 50 ng/g, respectively. The recoveries of TCs from both honey and royal jelly were 75-120%.

  10. Application of solid/liquid extraction for the gravimetric determination of lipids in royal jelly.

    PubMed

    Antinelli, Jean-François; Davico, Renée; Rognone, Catherine; Faucon, Jean-Paul; Lizzani-Cuvelier, Louisette

    2002-04-10

    Gravimetric lipid determination is a major parameter for the characterization and the authentication of royal jelly quality. A solid/liquid extraction was compared to the reference method, which is based on liquid/liquid extraction. The amount of royal jelly and the time of the extraction were optimized in comparison to the reference method. Boiling/rinsing ratio and spread of royal jelly onto the extraction thimble were identified as critical parameters, resulting in good accuracy and precision for the alternative method. Comparison of reproducibility and repeatability of both methods associated with gas chromatographic analysis of the composition of the extracted lipids showed no differences between the two methods. As the intra-laboratory validation tests were comparable to the reference method, while offering rapidity and a decrease in amount of solvent used, it was concluded that the proposed method should be used with no modification of quality criteria and norms established for royal jelly characterization.

  11. 76 FR 37300 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Royal Fiberglass Pools...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ...EPA is proposing to approve into the Illinois State Implementation Plan (SIP) an adjusted standard for Royal Fiberglass Pools (``Royal'') at its Dix, Illinois facility. On November 8, 2010, the Illinois Environmental Protection Agency (IEPA) submitted to EPA for approval an adjustment to the general rule, Use of Organic Material Rule, commonly known as the eight pound per hour (8 lb/hr) rule, as it applies to emissions of volatile organic matter (VOM) from Royal's pool manufacturing facility. The adjusted standard relieves Royal from being subject to the general rule for VOM emissions from its Dix facility. EPA is approving this SIP revision because it will not interfere with attainment or maintenance of the ozone National Ambient Air Quality Standard (NAAQS).

  12. LASERS IN THE UK, PART I: THE ROYAL RADAR ESTABLISHMENT (RRE), GREAT MALVERN, WORCESTERSHIRE.

    DTIC Science & Technology

    Solid state laser research and development at the Royal Radar Establishment is described. Particular attention is devoted to new crystalline ... materials . Measurement of photon density fluctuation in coherent source is also reported. (Author)

  13. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees

    PubMed Central

    Spannhoff, Astrid; Kim, Yong Kee; Raynal, Noel J -M; Gharibyan, Vazganush; Su, Ming-Bo; Zhou, Yue-Yang; Li, Jia; Castellano, Sabrina; Sbardella, Gianluca; Issa, Jean-Pierre J; Bedford, Mark T

    2011-01-01

    Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly—the secretion produced by the hypopharyngeal and mandibular glands of worker bees—has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is probably driven, in part, by HDACi activity in royal jelly. PMID:21331099

  14. The Royal College of Nursing: a century of dedication to nurses and patients.

    PubMed

    Davies, Janet

    Janet Davies, Chief Executive of the Royal College of Nursing, reflects on the RCN's achievements since its foundation in 1916, and looks ahead to the challenges the nursing profession faces in 2016 and beyond.

  15. Doctor William Gunn (1804-1890): From the South Pacific Islands to Chatham Royal Dockyard.

    PubMed

    Biddle, Richard

    2016-11-24

    Doctor William Gunn had a long and varied career in the Royal Navy. After spending time on anti-slavery patrols along the west coast of Africa, he was posted to the south Pacific. At Pitcairn Island, he treated the inhabitants during an influenza epidemic, proving himself to be a determined and dedicated practitioner. Subsequently, he was appointed head of the medical department at Chatham Royal Dockyard (1859-1865), an appointment that coincided with the final stages of the Royal Navy's transition from sail and wood to steam and iron. The impact of these changes on the health of dockworkers was quickly felt at Chatham, and Gunn found himself in charge during the building of the first iron warship in a royal dockyard. His story thus offers a window through which to observe a practitioner confronting the health issues and medical uncertainties thrown up by technological change in the Victorian era.

  16. Mount Royal College: Building a 16 1/2 Acre Environment Around the Individual

    ERIC Educational Resources Information Center

    College and University Business, 1973

    1973-01-01

    Examines the design, programming, the audiovisual, physical plant and food service operations of Mount Royal College in Calgary, Canada, that attempts to reduce the distance between living and learning. (Author/PG)

  17. 'Any style but gothic': Building a home for the Royal College of Physicians of Ireland.

    PubMed

    Wheelock, H

    2016-06-01

    On 15 July 1864 the Royal College of Physicians of Ireland held its first business meeting in its newly built home at 6 Kildare Street, Dublin. Although the Royal College of Physicians of Ireland had been in existence for over 200 years this was the first occasion that a College meeting had been held in a building owned by the College. This paper looks at the history behind the construction of a home for the Royal College of Physicians of Ireland. It will examine why it took over 200 years for the Physicians to find a permanent home, how they ended up with the building they did, and what they borrowed from the Royal College of Physicians in Edinburgh in the process.

  18. At the Crossroads of Cyber Warfare: Signposts for the Royal Australian Air Force

    DTIC Science & Technology

    2011-06-01

    At the Crossroads of Cyber Warfare : Signposts for the Royal Australian Air Force by Craig Stallard, Squadron leader, Royal...in the conduct of cyber warfare . The 2009 Defence White Paper provided some clarity by indentifying cyber warfare as critical to the maintenance...of national security, but left open the most important issue: should cyber warfare be a joint engagement or a service oriented fight? The RAAF

  19. The Royal Navy’s New-Generation Type 45 Destroyer. Acquisition Options and Implications

    DTIC Science & Technology

    2002-01-01

    Future Offshore Patrol Vessel FPSO Floating Production, Storage and Offloading vessel xxiii xxiv The Royal Navy’s New-Generation Type 45 Destroyer FSC...the conversion of a Floating Production, Storage and Offloading ( FPSO ) vessel, and a naval order for two Alternative Landing Ships Logistics (ALSL...Frigates, various Marine (OPVs) for Royal Brunei design work Navy Offshore SupplyVessel, ALSL, Landing Craft Utility, miscellaneous module and Auxiliary

  20. Generic task-related occupational requirements for Royal Naval personnel.

    PubMed

    Bilzon, J L J; Scarpello, E G; Bilzon, E; Allsopp, A J

    2002-12-01

    Physical tests and selection criteria have historically been used by many military organizations. However, the standards associated with them have come under increasing scrutiny in recent years. This paper describes a series of experiments that were conducted to establish task-related occupational tests and standards (TBTs) for Royal Naval (RN) personnel. A total of 172 (106 male and 66 female) RN personnel volunteered for these experiments, which were designed to: identify the anthropometric requirements for operating various safety hatches and doors on board a RN Frigate (TBT1); quantify the metabolic demands of shipboard firefighting tasks and establish an aerobic fitness standard (TBT2); and identify a battery of tests to predict performance of shipboard casualty-carrying tasks (TBT3). Whilst all subjects completed the criterion tasks during TBT1, performance of the bulkhead door (BD) escape task was related to height (r = 0.50- 0.62, P < 0.05) and vertical reach (r = 0.42-0.54, P < 0.05), with shorter subjects struggling to perform the task. During TBT2, the mean metabolic demand of representative firefighting tasks was 38 ml/min/kg, which must be sustained for 20-30 min. Finally, a battery of tests incorporating measures of lean body mass, fat mass, standing broad jump, 20 m sprint, press-ups, sit-ups and grip strength produced a high correlation (r = 0.89, P < 0.01) with casualty-carrying task performance. From the results of these experiments, it is recommended that RN personnel perform the BD simulation task at the recruitment stage (TBT1), to prove that they possess the anthropometric characteristics commensurate with survival at sea. Secondly, personnel should be frequently screened to ascertain whether they have the maximal aerobic power (41 ml/min/kg) commensurate with shipboard firefighting for 20-30 min (TBT2). Finally, they should perform the battery of proposed tests and score at least 34 points, in order to establish whether they have the

  1. Surgical training in the Netherlands.

    PubMed

    Borel-Rinkes, Inne H M; Gouma, Dirk J; Hamming, Jaap F

    2008-10-01

    Surgical training in the Netherlands has traditionally been characterized by learning on the job under the classic master-trainee doctrine. Over the past decades, it has become regionally organized with intensive structural training courses, and a peer-based quality control system. Recently, the nationwide programme has been modernized further and now involves a systematic, competency-based education with structural training courses, formalized assessment and room for reflection by residents under the supervision of surgical teaching groups. To this end, a uniform web-based digital portfolio is being introduced to facilitate monitoring of the individual resident's progress. Though requiring inspirational leadership, commitment, and determination, this modernization has sparked enthusiasm among trainees and teachers.

  2. Train suicides in The Netherlands.

    PubMed

    van Houwelingen, Cornelis A J; Kerkhof, Ad J F M; Beersma, Domien G M

    2010-12-01

    Little is known about train suicide and factors influencing its prevalence. This study tests the hypotheses that railway density, railway transportation volume, familiarity with railway transportation and population density contribute to train suicide. It also tests the relationship between train suicide and general population suicide and examines the prevalence and the characteristics of high-risk locations and their contribution to the grand total of train suicides. Trends in train suicides were compared with trends in railway track length, train kilometres, passenger kilometres and national suicide figures over the period 1950-2007. The geographical distribution over the national network over the period 1980-2007 was studied. Data were obtained from The Netherlands Railways, Prorail and Statistics Netherlands. 1. The incidence of train suicides is unrelated to railway parameters. 2. Being familiar with railway transportation as a passenger is not a contributory factor. 3. Train suicide rates are unrelated to regional population density. 4. The incidence of train suicides parallels that of general population suicides. 5. Half of the train suicides took place at a limited number of locations, the most important of which were situated within a village or town and were close to a psychiatric hospital. Most conclusions are based on correlational relationships between variables. 1. Train suicide trends reflect trends in general population suicides. 2. Increased train transportation does not lead to more train suicides. 3. The prevention of train suicide at high-risk locations (HRLs) in built-up areas and near psychiatric hospitals deserves first priority. Copyright © 2010 Elsevier B.V. All rights reserved.

  3. Compliance of ENT emergency surgery with the Royal College of Surgeons standards

    PubMed Central

    Sharma, S; Yao, A; Mahalingam, S; Persaud, R

    2016-01-01

    Introduction In 2011 The Royal College of Surgeons of England (RCS) set out best practice standards for emergency surgery. This national pilot audit aimed to determine the compliance of otolaryngology departments in England with these published guidelines. Methods A 26-item online questionnaire was devised that encompassed all the 36 best practices as set out by the RCS for ear, nose and throat (ENT) surgery. This was sent to ENT trainees and consultants based at units in England providing emergency ENT services. Results Data were obtained from 55 of the 102 units (response rate: 54%). A mean compliance of 71% was achieved (range: 25–94%). No units achieved all of the best practices. The standards with the highest compliance included 24-hour availability of blood transfusion and haematology opinion for patients with epistaxis, availability of a consultant or ST3/equivalent for immediate discussion of severe post-tonsillectomy bleeding, 24-hour access to blood transfusion for arrest of haemorrhage and immediate theatre access for arrest of haemorrhage. The areas with the lowest compliance were provision of a pathway for angiography/embolisation for epistaxis and provision of an equipped ENT room on a paediatric ward. Conclusions This audit has highlighted that the majority of departments in England are providing a good standard of ENT emergency care. There is room for improvement in certain areas, such as the provision of an embolisation pathway in the context of refractory epistaxis. We hope that this audit will encourage ENT departments to evaluate their current provision of emergency care and institute changes (where necessary) to maintain and improve their practices. PMID:26688399

  4. Evolutionary institutionalism.

    PubMed

    Fürstenberg, Dr Kai

    Institutions are hard to define and hard to study. Long prominent in political science have been two theories: Rational Choice Institutionalism (RCI) and Historical Institutionalism (HI). Arising from the life sciences is now a third: Evolutionary Institutionalism (EI). Comparative strengths and weaknesses of these three theories warrant review, and the value-to-be-added by expanding the third beyond Darwinian evolutionary theory deserves consideration. Should evolutionary institutionalism expand to accommodate new understanding in ecology, such as might apply to the emergence of stability, and in genetics, such as might apply to political behavior? Core arguments are reviewed for each theory with more detailed exposition of the third, EI. Particular attention is paid to EI's gene-institution analogy; to variation, selection, and retention of institutional traits; to endogeneity and exogeneity; to agency and structure; and to ecosystem effects, institutional stability, and empirical limitations in behavioral genetics. RCI, HI, and EI are distinct but complementary. Institutional change, while amenable to rational-choice analysis and, retrospectively, to criticaljuncture and path-dependency analysis, is also, and importantly, ecological. Stability, like change, is an emergent property of institutions, which tend to stabilize after change in a manner analogous to allopatric speciation. EI is more than metaphorically biological in that institutional behaviors are driven by human behaviors whose evolution long preceded the appearance of institutions themselves.

  5. Institution Closures.

    ERIC Educational Resources Information Center

    Hayden, Mary F., Ed.; And Others

    1995-01-01

    This newsletter theme issue focuses on the need to accelerate the closing of institutions for people with mental retardation. Articles are by both current and former residents of institutions and by professionals, and include: "The Realities of Institutions" (Tia Nelis); "I Cry Out So That I Won't Go Insane" (Mary F. Hayden); "Trends in…

  6. Staff exchange within and between nursing homes in The Netherlands and potential implications for MRSA transmission.

    PubMed

    VAN Gaalen, R D; Hopman, H A; Haenen, A; VAN DEN Dool, C

    2017-03-01

    A recent countrywide MRSA spa-type 1081 outbreak in The Netherlands predominantly affected nursing homes, generating questions on how infection spreads within and between nursing homes despite a low national prevalence. Since the transfer of residents between nursing homes is uncommon in The Netherlands, we hypothesized that staff exchange plays an important role in transmission. This exploratory study investigated the extent of former (last 2 years) and current staff exchange within and between nursing homes in The Netherlands. We relied on a questionnaire that was targeted towards nursing-home staff members who had contact with residents. We found that 17·9% and 12·4% of the nursing-home staff formerly (last 2 years) or currently worked in other healthcare institutes besides their job in the nursing home through which they were selected to participate in this study. Moreover, 39·7% of study participants worked on more than one ward. Our study shows that, in The Netherlands, nursing-home staff form a substantial number of links between wards within nursing homes and nursing homes are linked to a large network of healthcare institutes through their staff members potentially providing a pathway for MRSA transmission between nursing homes and throughout the country.

  7. Institutional paranoia.

    PubMed

    Kulenović, M

    1995-01-01

    Taken separately, the concepts of institution and paranoia have no bearing on this work. They acquire their full new meaning as "institutional paranoia" only when they are taken together. Institutional paranoia is not a mental illness in the ordinary sense. It is a state, a condition, which exists in all associations and communities which have the same goal and concurrent intentions. The author's analysis of the problem is based on observation and monitoring of circumstances, discussions and content analysis, as well as on the use of questionnaires in several health institutions over a long period of time. He focuses his attention primarily on health, political, and economic institutions. The results of observation and analysis point to some interesting phenomena which require further study, regardless of their positive or negative outcome. With additional interventions, the content and dynamics of this process in institutions can contribute to the gradual diminishing of institutional paranoia, and sometimes its complete disappearance over a long time.

  8. Experiential Education, Outdoor Adventure As a Modality in Youth Care and Residential Treatment. A Survey of Programs, Principles, Research and Practice on the European Continent, Especially the Netherlands.

    ERIC Educational Resources Information Center

    Duindam, Ton

    Orthopedagogisch Centrum Michiel is a multifunctional institution in the eastern Netherlands for youth with emotional problems. The staff of the institution's residential treatment center has gradually become involved with outdoor experiential education through training programs, conferences, special projects, and supervised programs. Activities…

  9. [Potentially excluded population from health coverage and health impact since Royal Decree 16/2012: The Central Catalonia experience].

    PubMed

    Álamo-Junquera, Dolores; Sala, Núria; Millet, Joan-Pau; Ortega-Gutiérrez, Lluïsa; Planas-Giner, Albert; Rovira, Carol; Comet, Dolors

    2015-01-01

    To assess the proportion of population potentially excluded from healthcare coverage since the Royal Decree-Law 16/2012. To describe the use of health services, the distribution of chronic and infectious diseases, and the pharmaceutical costs in 2012 of the persons potentially excluded compared to the those who maintain their coverage. An observational analytical cross-sectional study was designed and conducted on a Primary Care based population in the Central Catalonia Management Area of the Institut Català de la Salut PARTICIPANTS AND MAIN MEASUREMENTS: Individuals potentially excluded since the application of the Royal Decree-Law 16/2012 were selected and compared with individuals who maintained their healthcare coverage, randomly matched by sex, age and Primary Care service. The information obtained included the use of health services, the distribution of chronic and infectious diseases, and the pharmaceutical costs during the year 2012. A total of 1,699 individuals were identified as potentially excluded from healthcare coverage, 0.53% of the total of population (51.4% men), with a median of age of 34years (interquartile range, 28-43). The use of healthcare services, the chronic morbidity recorded, and the pharmaceutical costs during the year 2012 of the excluded individuals was lower than those of the non-excluded ones (P<.001). On the other hand, the infectious morbidity was higher in the excluded individuals (P<.001). The results of the study suggests that this legislative measure does not seem to be justified for medical or economic reasons. It could also cause public health problems and contribute to the risk of social fracture. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

  10. Educational Innovation between Freedom and Fixation: The Cultural-Political Construction of Innovations in Early Childhood Education in the Netherlands

    ERIC Educational Resources Information Center

    van Oers, Bert

    2013-01-01

    As in many countries, in the Netherlands, governmental policy regulates the decisions of schools and care providers that concern and the control of the quality of education and care. Article 23 of the Dutch Constitution defines a fundamental right of freedom in matters of education within the context of institutions such as schools and other…

  11. Educational Innovation between Freedom and Fixation: The Cultural-Political Construction of Innovations in Early Childhood Education in the Netherlands

    ERIC Educational Resources Information Center

    van Oers, Bert

    2013-01-01

    As in many countries, in the Netherlands, governmental policy regulates the decisions of schools and care providers that concern and the control of the quality of education and care. Article 23 of the Dutch Constitution defines a fundamental right of freedom in matters of education within the context of institutions such as schools and other…

  12. The absolute configurations of hydroxy fatty acids from the royal jelly of honeybees (Apis mellifera).

    PubMed

    Kodai, Tetsuya; Nakatani, Takafumi; Noda, Naoki

    2011-03-01

    9-Hydroxy-2E-decenoic acid (9-HDA) is a precursor of the queen-produced substance, 9-oxo-2E-decenoic acid (9-ODA), which has various important functions and roles for caste maintenance in honeybee colonies (Apis mellifera). 9-HDA in royal jelly is considered to be a metabolite of 9-ODA produced by worker bees, and it is fed back to the queen who then transforms it into 9-ODA. Recently we found that 9-HDA is present in royal jelly as a mixture of optical isomers (R:S, 2:1). The finding leads us to suspect that chiral fatty acids in royal jelly are precursors of semiochemicals. Rather than looking for semiochemicals in the mandibular glands of the queen bee, this study involves the search for precursors of pheromones from large quantities of royal jelly. Seven chiral hydroxy fatty acids, 9,10-dihydroxy-2E-decenoic, 4,10-dihydroxy-2E-decenoic, 4,9-dihydroxy-2E-decenoic, 3-hydroxydecanoic, 3,9-dihydroxydecanoic, 3,11-dihydroxydodecanoic, and 3,10-dihydroxydecanoic acids were isolated. The absolute configurations of these acids were determined using the modified Mosher's method, and it was revealed that, similar to 9-HDA, five acids are present in royal jelly as mixtures of optical isomers.

  13. Influence of royal jelly on the reproductive function of puberty male rats.

    PubMed

    Yang, Anshu; Zhou, Ming; Zhang, Li; Xie, Guoxiu; Chen, Hongbing; Liu, Zhiyong; Ma, Wei

    2012-06-01

    The adverse effects of royal jelly on the reproductive system of puberty male rats were investigated. Royal jelly was daily administered by gavage to Sprague-Dawley rats at doses 200, 400, and 800 mg/kg for 4 weeks. The body weight and organ coefficients were determined. Sperm count, spermatozoa abnormality, and testicular histopathology were examined through light microscopy. Radioimmunoassay was used to detect serum hormones. The dietary exposure to royal jelly did not affect body weight, but the organ coefficients for the pituitary and testis in the high-dose group were decreased significantly compared with the control group, and significant changes in the microstructure of the testis were observed. No significant differences in sperm count were observed among all groups, however, the sperm deformity rate in the high-dose group increased significantly. Serum hormones in the high-dose group were significantly different from the control group. After royal jelly was stopped for 14 days, the adverse changes were partially reversed and returned to levels close to those in the control group. In conclusion, high-dose royal jelly oral administration for 4 weeks adversely affected the reproductive system of pubescent male rats, but the unfavorable effects are alleviated to some extent by cessation of administration.

  14. Nephroprotective effect of bee honey and royal jelly against subchronic cisplatin toxicity in rats.

    PubMed

    Ibrahim, Abdelazim; Eldaim, Mabrouk A Abd; Abdel-Daim, Mohamed M

    2016-08-01

    Cisplatin is one of the most potent and effective chemotherapeutic agents. However, its antineoplastic use is limited due to its cumulative nephrotoxic side effects. Therefore, the present study was undertaken to examine the nephroprotective potential of dietary bee honey and royal jelly against subchronic cisplatin toxicity in rats. Male Wistar rats were randomly divided into controls, cisplatin-treated, bee honey-pretreated cisplatin-treated and royal jelly-pretreated cisplatin-treated groups. Bee honey and royal jelly were given orally at doses of 20 and 100 mg/kg, respectively. Subchronic toxicity was induced by cisplatin (1 mg/kg bw, ip), twice weekly for 10 weeks. Cisplatin treated animals revealed a significant increase in serum level of renal injury products (urea, creatinine and uric acid). Histopathologically, cisplatin produced pronounced tubulointerstitial injuries, upregulated the fibrogenic factors, α-smooth muscle actin (α-SMA) and transforming growth factor β1(TGF-β1), and downregulated the cell proliferation marker, bromodeoxyuridine (Brdu). Dietary bee honey and royal jelly normalized the elevated serum renal injury product biomarkers, improved the histopathologic changes, reduced the expression of α-SMA and TGF-β1 and increased the expression of Brdu. Therefore, it could be concluded that bee honey, and royal jelly could be used as dietary preventive natural products against subchronic cisplatin-induced renal injury.

  15. [Research on morphological genetic marker of honeybee (Apis melli fera ligustica) in royal jelly production performance].

    PubMed

    Su, Song-Kun; Chen, Sheng-Lu

    2003-11-01

    The lengths of hypopharyngeal glands (HG) from the left and right side were determined in 19 workers of honeybee(Apis mellifera ligustica). There were no significant differences (P<0.05) in length between the left and the right in one worker's hypopharyngeal gland. Three hundred and thirty workers were collected from eleven colonies of "ZND No.1" Italian honeybee(Apis mellifera ligustica) respectively. Head weight, body weight, ratio between head weight and body weight,bursa number and length of hypopharyngeal gland(HG)were tested in these samples. Royal jelly productions were determined during the flowing period of rape and Chinese milk retch from March 30 to April 26 in Chun'an County of Zhejiang Province in 2001. The correlation analysis between royal jelly production and head weight, ratio between head weight and body weight, bursa number of HG,and length of HG were conducted. The correlation coefficient between royal jelly production and length of HG was the largest. The correlation coefficient between royal jelly production and bursa number was the second. It was suggested that the length of HG could be used as one of genetic markers for the production performance of royal jelly.

  16. Effects of Royal Jelly Supplementation on Body Weight and Dietary Intake in Type 2 Diabetic Females

    PubMed Central

    Pourmoradian, Samira; Mahdavi, Reza; Mobasseri, Majid; Faramarzi, Elnaz; Mobasseri, Mehrnoosh

    2012-01-01

    Background: The objective of the current study was to assess the effects of royal jelly supple-mentation on body weight, total daily energy and macronutrients intakes in type2 diabetic fe-males. Methods: In this randomized clinical trial, fifty female volunteers with type2 diabetes were as-signed into the supplemented (n=25) and placebo (n=25) groups, given a daily dose of 1000 mg royal jelly soft gel or placebo, for 8 weeks, respectively. Before and after the intervention, body weight and height of subjects were measured and body mass index was calculated. Dietary intake of patients was assessed using 24-hour food recall questionnaire for three non consecutive days (including 1 weekend day) and analyzed with Nutritionist IV software. The normally distributed data were compared using paired and independent t-tests, where appropriate. Results: Royal jelly supplementation significantly (P<0.01) decreased the mean body weight (72.45±4.42 vs. 71.00±6.44 kg) while it increased insignificantly in placebo group (73.02±6.44 vs 73.52±6.80 kg). Royal jelly supplementation resulted in significant decrease of mean daily total energy (P<0.01) and carbohydrate (P<0.01) intakes, while in placebo group the mean daily total energy and fat intakes were increased significantly (P<0.05). Conclusion: Supplementation with royal jelly may be beneficial in weight management of di-abetic patients. PMID:24688939

  17. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits.

    PubMed

    Pasupuleti, Visweswara Rao; Sammugam, Lakhsmi; Ramesh, Nagesvari; Gan, Siew Hua

    2017-01-01

    There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

  18. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

    PubMed Central

    Sammugam, Lakhsmi; Ramesh, Nagesvari

    2017-01-01

    Background There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions. PMID:28814983

  19. Governing Healthcare through Performance Measurement in Massachusetts and the Netherlands

    PubMed Central

    Van der Wees, Philip J.; der Sanden, Maria W.G. Nijhuis-van; van Ginneken, Ewout; Ayanian, John Z.; Schneider, Eric C.; Westert, Gert P.

    2016-01-01

    Massachusetts and the Netherlands have implemented comprehensive health reforms, which have heightened the importance of performance measurement. The performance measures addressing access to health care and patient experience are similar in the two jurisdictions, but measures of processes and outcomes of care differ considerably. In both jurisdictions, the use of health outcomes to compare the quality of health care organizations is limited, and specific information about costs is lacking. New legislation in both jurisdictions led to the establishment of institutes to monitor the quality of care, similar mandates to make the performance of health care providers transparent, and to establish a shared responsibility of providers, consumers and insurers to improve the quality of health care. In Massachusetts a statewide mandatory quality measure set was established to monitor the quality of care. The Netherlands is stimulating development of performance measures by providers based on a mandatory framework for developing such measures. Both jurisdictions are expanding the use of patient-reported outcomes to support patient care, quality improvement, and performance comparisons with the aim of explicitly linking performance to new payment incentives. PMID:24138729

  20. Plasma medicine in the Netherlands

    NASA Astrophysics Data System (ADS)

    Kroesen, Gerrit

    2012-10-01

    Eindhoven, the Netherlands was one of the locations were Plasma Medicine originated: Eva Stoffels was one of the founders of the field. Since then, the attention for the field steadily increased. Nowadays, strong collaborations exist between the Eindhoven University of Technology (TU/e) and the Red Cross Burn Wound Hospital in Beverwijk, the Amsterdam Medical Center, the Maxima Medical Center in Eindhoven, the Radboud University in Nijmegen, the Free University in Amsterdam, and also companies, both large industries (Philips) and SME's (Vabrema, Lavoisier, Plastech). At TU/e we focus on the plasma itself: developing real time non-invasive diagnostics like TALIF, LIF, IF absorption, Thomson, Rayleigh and Raman scattering, mass spectroscopy, etc, while at the same time developing numerical models on the MD2D platform. For the biology, microbiology and medical aspects we rely on our colleagues who have specialized in those areas. Lesions that are studied are burn wounds, permanent inflammations, diabetic feet, skin infections, and internal diseases like Crohn's disease.

  1. Faithful interpreters? Translation theory and practice at the early Royal Society

    PubMed Central

    Henderson, Felicity

    2013-01-01

    The early Fellows of the Royal Society received letters, papers and printed books written in several European vernaculars. In many cases a translation was needed to make these texts accessible. Translators, though, had to negotiate the Society's corporate views on language and prose style, and also prevailing contemporary theories of literary translation set out by popular poets such as John Dryden and Abraham Cowley. This article examines the translation practices of early Fellows of the Royal Society, showing that translations formed part of a set of knowledge-making processes at meetings. It also discusses the statements about translation theory found in the prefaces to printed volumes produced by or for Royal Society Fellows, arguing that although translators were aware of the requirement for a faithful translation, in fact they often modified their source texts to make them more useful for an English audience.

  2. Identifications of ancient Egyptian royal mummies from the 18th Dynasty reconsidered.

    PubMed

    Habicht, M E; Bouwman, A S; Rühli, F J

    2016-01-01

    For centuries, ancient Egyptian Royal mummies have drawn the attention both of the general public and scientists. Many royal mummies from the New Kingdom have survived. The discoveries of the bodies of these ancient rulers have always sparked much attention, yet not all identifications are clear even nowadays. This study presents a meta-analysis to demonstrate the difficulties in identifying ancient Egyptian royal mummies. Various methods and pitfalls in the identification of the Pharaohs are reassessed since new scientific methods can be used, such as ancient DNA-profiling and CT-scanning. While the ancestors of Tutankhamun have been identified, some identities are still highly controversial (e.g., the mystery of the KV-55 skeleton, recently most likely identified as the genetic father of Tutankhamun). The meta-analysis confirms the suggested identity of some mummies (e.g., Amenhotep III, Thutmosis IV, and Queen Tjye). © 2016 Wiley Periodicals, Inc.

  3. [Institutional Renewal].

    ERIC Educational Resources Information Center

    Brown, Peggy, Ed.

    1983-01-01

    The theme of this journal issue is "Institutional Renewal." Projects designed to address the issues of the 1980s at 18 colleges are described, and 15 definitions of institutional renewal are presented. Participating colleges were provided expert advice through the Association of American College's (AAC) Project Lodestar (renamed…

  4. ‘Because of Poverty brought into Hospital: . . .’A Casenote-Based Analysis of the Changing Role of the Edinburgh Royal Maternity Hospital, 1850-1912

    PubMed Central

    Nuttall, Alison

    2008-01-01

    Summary Although the shift from a social to a medical function which occurred in nineteenth-century general hospitals has been explored, the occurrence of such a change in maternity hospitals has not been considered. Recent analyses of such institutions have examined particular aspects only, and thus give a somewhat static picture. This paper uses analysis of patient records (themselves an under-exploited resource) to explore the changing function of the Edinburgh Royal Maternity Hospital from a provider of shelter during childbirth to the destitute to a source of skilled medical care. It concludes that, although the Hospital had adopted the outward features of a medical institution by 1890, its casebooks suggest that its purpose only truly changed in the early twentieth century, and thus can perhaps be more appropriately linked with national anxiety regarding the health of babies and their mothers. PMID:18605328

  5. [Tropical veterinary medicine and education in The Netherlands].

    PubMed

    Uilenberg, Gerrit

    2008-01-01

    in this lecture an overview is given of the development of tropical veterinary medicine and education in The Netherlands after the Dutch colonial period. The starting point is the development of tropical veterinary medicine in general, especially in Europe and Africa. It is pointed out that just now it is very important to have specialists in tropical diseases not only in the tropics but also in the western world since globalization involves the import of a lot of tropical diseases. The speaker is an advocate of a course on tropical veterinary medicine on an European level, but at the same time he is sceptical about it. In the second part he gives an overview of the education programme on tropical veterinary medicine from the foundation of the Institute at Utrecht University in 1948 until its decline.

  6. Euthanasia in Belgium, the Netherlands and Luxembourg.

    PubMed

    2013-11-01

    Each of the Benelux countries (Belgium, Luxembourg, Netherlands) has enacted legislation that partially decriminalises euthanasia, defined as an act that intentionally terminates someone's life at their request. In the Netherlands and Luxembourg, but not in Belgium, the legislation partially decriminalised assisted suicide at the same time. In all three countries, euthanasia can only be performed by a doctor, in response to the patient's voluntary and well-considered request, and for patients who have an incurable disease that causes unbearable suffering, without any prospect of relief. In the Netherlands, minors can request euthanasia as of the age of 12 years. In 2011, reported euthanasia accounted for about 1% of deaths in Belgium and 3% in the Netherlands. In 75% of cases, cancer was the disease leading to a request for euthanasia. In the Netherlands, the number of cases of euthanasia reported by doctors in surveys matches the number that is officially declared. In Belgium, it is thought that there are as many unreported as reported cases of euthanasia. Since the enactment of euthanasia legislation, fewer deaths involve the intentional administration of lethal drugs without an explicit request from the patient.

  7. High Royal Jelly-Producing Honeybees (Apis mellifera ligustica) (Hymenoptera: Apidae) in China.

    PubMed

    Cao, Lian-Fei; Zheng, Huo-Qing; Pirk, Christian W W; Hu, Fu-Liang; Xu, Zi-Wei

    2016-04-01

    China is the largest producer and exporter of royal jelly (RJ) in the world, supplying >90% of the global market. The high production of RJ in China is principally owing to the high RJ-producing lineage of honeybees (Apis mellifera ligustica Spinola, 1806) established by beekeepers in the 1980s. We describe the development of high royal jelly-producing honeybees and the management of this lineage today. Previous research and recent advances in the genetic characterization of this lineage, and the molecular markers and mechanisms associated with high RJ production are summarized. The gaps in our knowledge and prospects for future research are also highlighted.

  8. Presidential addresses of the Royal Society of Tropical Medicine and Hygiene: 1907-2013.

    PubMed

    Hay, Simon I; McHugh, Gerri M

    2013-10-01

    Presidents have been required to give an inaugural address on commencing office at the Royal Society of Tropical Medicine and Hygiene (RSTMH) since its foundation in 1907. All presidential addresses were identified, sourced and assembled into an annotated bibliography. The majority of presidential addresses have been published in Transactions of the Royal Society of Tropical Medicine and Hygiene. Unpublished and in some cases 'lost' contributions have now been sourced where possible and archived at the RSTMH. This unique, rich and rewarding archive provides a vista into the development of the RSTMH and the discipline of tropical medicine. The archive is freely available to all.

  9. Glacial and postglacial geologic history of Isle Royale National Park, Michigan

    USGS Publications Warehouse

    Huber, N. King

    1973-01-01

    Isle Royale was overridden by glacial ice during each of the four major glaciations of the Pleistocene Epoch, and each successive glaciation essentially obliterated all direct evidence of preceding glaciations on the island. In the waning phase of the last major glaciation, the Wisconsin Glaciation, the frontal ice margin retreated northward from at least the greater part of the Lake Superior basin, then readvanced into the basin during Valders time, about 11,000 years ago. We can attribute to the Valders ice the final aspect of glaciation on Isle Royale, including both erosional and depositional features. It is impossible to estimate the quantity of glacial debris or other surficial materials that might have been present on Isle Royale prior to the Valders readvance, but the readvancing ice appears to have removed most of what might have been present, as judged by the thin surficial cover on the eastern two-thirds of the island today. During the Valders retreat, a series of lakes formed in the Lake Superior basin in front of the retreating ice margin. The retreating ice opened successively lower outlets, and thus the general trend of lake elevations is downward. Distinct lake stages reflect periods of relative stability during which well- defined shoreline features developed. The ice front forming the north margin of the earlier lakes probably remained south of Isle Royale until about the time of glacial Lake Beaver Bay, when it retreated to a position straddling Isle Royale west of Lake Desor. Abundant deposits of glacial debris were left upon the newly deglaciated west end of the island, and the ice front remained stable long enough to build a complex of ice-margin deposits across the island. Shorelines formed by the glacial lake associated with this ice front are found on the western part of the island about 200 feet above present Lake Superior. Subsequent renewed and complete retreat of the ice margin from Isle Royale was rapid enough that only a minor amount

  10. Presidential addresses of the Royal Society of Tropical Medicine and Hygiene: 1907–2013

    PubMed Central

    Hay, Simon I.; McHugh, Gerri M.

    2013-01-01

    Presidents have been required to give an inaugural address on commencing office at the Royal Society of Tropical Medicine and Hygiene (RSTMH) since its foundation in 1907. All presidential addresses were identified, sourced and assembled into an annotated bibliography. The majority of presidential addresses have been published in Transactions of the Royal Society of Tropical Medicine and Hygiene. Unpublished and in some cases ‘lost’ contributions have now been sourced where possible and archived at the RSTMH. This unique, rich and rewarding archive provides a vista into the development of the RSTMH and the discipline of tropical medicine. The archive is freely available to all. PMID:24026462

  11. Captain Edmond Halley, F.R.S., Royal Navy, and the practice of navigation.

    NASA Astrophysics Data System (ADS)

    Waters, D. W.

    Edmond Halley, Fellow of the Royal Society, Astronomer Royal (1720 - 42), is rarely thought of or mentioned as a sea captain or a scientific seaman. Yet his shiphandling in the course of three voyages in command of Their Majesties' Pink Paramore (1698 - 1701) is in itself proof that his seamanship was of the highest order. Similarly, the practical innovations that he made in the arts of navigation and pilotage, in the form of printed sea charts and sailing directions, were fundamentally scientific and therefore remain relevant today.

  12. Burn Institute

    MedlinePlus

    ... a resource to the community. Learn more The Burn Institute reaches thousands of children and adults each year through fire and burn prevention education, burn survivor support programs and the ...

  13. Ageing aircraft research in the Netherlands

    NASA Technical Reports Server (NTRS)

    Dejonge, J. B.; Bartelds, G.

    1992-01-01

    The problems of aging aircraft are worldwide. Hence, international cooperative actions to overcome or prevent problems should be taken. The Federal Aviation Administration (FAA) and the Netherlands Civil Aviation Department (RLD) signed a Memorandum of Cooperation in the area of structural integrity, with specific reference to research on problems in the area of aging aircraft. Here, an overview is given of aging research that is going on in the Netherlands. The work described is done largely at the National Aerospace Laboratory; much of the research is part of the forementioned cooperative agreement.

  14. Ageing aircraft research in the Netherlands

    NASA Technical Reports Server (NTRS)

    Dejonge, J. B.; Bartelds, G.

    1992-01-01

    The problems of aging aircraft are worldwide. Hence, international cooperative actions to overcome or prevent problems should be taken. The Federal Aviation Administration (FAA) and the Netherlands Civil Aviation Department (RLD) signed a Memorandum of Cooperation in the area of structural integrity, with specific reference to research on problems in the area of aging aircraft. Here, an overview is given of aging research that is going on in the Netherlands. The work described is done largely at the National Aerospace Laboratory; much of the research is part of the forementioned cooperative agreement.

  15. [In search of new paths. The self image of the Leopoldina and the Royal Society in London in its correspondence 1670-1677].

    PubMed

    Beeley, Philip; Scriba, Christoph J

    2008-01-01

    The article investigates the correspondence between members of the Academia Naturae Curiosorum and Henry Oldenburg, the secretary of the Royal Society, from 1670 until his death in 1677. In these years Oldenburg, originally a citizen of Bremen, continued to give support to fellow-countrymen such as Major and Sachs von Lewenhaimb whenever he could. But in contrast to the first ten years of the Royal Society, in which Oldenburg had often stressed differences in the character of the two scientific institutions, the future Leopoldina was able to establish a position of almost equal footing from 1670 onwards through its journal the Miscellanea curiosa medico-physica Academiae Naturae Curiosorum. This new self-confidence is reflected in the correspondence between Oldenburg and members of the first German academy. Alongside discussions on curiosities and monstrosities as well as on the topic of artificial gold, the discovery of phosphorus is a major theme of the correspondence in these later years. Oldenburg immediately recognized the importance of this German discovery and thereafter sought to obtain a sample of the substance for display to the Royal Society in London. His efforts were however fraught by various difficulties. Admittedly, Balduin early on sent a sample of his phosphorus to London, but it ultimately turned out not to be genuine. In the meantime Kunckel pretended to be the discoverer of the true phosphorus which he had seen when visiting Brand in Hamburg. When, in September 1677, Crafft eventually arrived in London with a sample of Brand's phosphorus Oldenburg had died tragically just a few days beforehand.

  16. Finding the Way: Improving Access to the Collections of the Royal Scottish Geographical Society

    ERIC Educational Resources Information Center

    Fenton, Candida

    2007-01-01

    Purpose: The purpose of this paper is to describe the Images for All digitisation project at the Royal Scottish Geographical Society, and lessons learned from it. Design/methodology/approach: This paper describes the background to the project and collections held. It focuses on the development of the project web site, the digitisation of 100…

  17. Co-Operative Problem-Solving at the Royal Docks Community School

    ERIC Educational Resources Information Center

    Martin, Ruth

    2013-01-01

    This article responds to Henry Tam's article in this issue of FORUM by exploring opportunities for co-operative problem-solving for staff and students of the Royal Docks Community School in the London Borough of Newham. Becoming a co-operative trust helped the school move out of special measures and develop a strategy of participation and…

  18. Field Philosophy: Environmental Learning and Moral Development in Isle Royale National Park

    ERIC Educational Resources Information Center

    Goralnik, Lissy; Nelson, Michael Paul

    2017-01-01

    We conducted a qualitative analysis of 5 years of student writing data to understand learning and moral development on a field philosophy course in Isle Royale National Park. We were interested in the connection between physical experiences in the natural world and the way students care about or value nonhuman beings, natural systems, and place.…

  19. FACTORS AFFECTING ENHANCED MERCURY BIOACCUMULATION IN INLAND LAKES OF ISLE ROYALE NATIONAL PARK, USA

    EPA Science Inventory

    We investigated factors causing mercury (Hg) concentrations in northern pike to exceed the consumption advisory level in some inland lakes of Isle Royale National Park. Using Hg-clean techniques, we collected water, zooplankton, macroinvertebrates, and fishes in 1998 and 1999 fro...

  20. Ruptured-yolk peritonitis and organochlorine residues in a royal tern

    USGS Publications Warehouse

    Blus, L.J.; Locke, L.N.; Stafford, C.J.

    1977-01-01

    Ruptured-yolk peritonitis was responsible for the death of a royal tern. Lodgment of eggs in the oviduct was probably due to reverse peristalsis brought about by breakage of the thin-shelled eggs and secondary bacterial infection. The thin shells were apparently not related to the low levels of DDE and other organochlorine pollutants found in tissues and egg contents.

  1. APPARENT 85KRYPTON AGES OF GROUNDWATER WITHIN THE ROYAL WATERSHED, MAINE, USA

    EPA Science Inventory

    85Kr activities were determined in 264 domestic and municipal wells from 2002-2004 in the Royal watershed (361 km2), Maine. Gas extraction for 85Kr from wells was effected directly via a well-head methodology permitting efficient widespread analys...

  2. FACTORS AFFECTING ENHANCED MERCURY BIOACCUMULATION IN INLAND LAKES OF ISLE ROYALE NATIONAL PARK, USA

    EPA Science Inventory

    Recent results have shown that 6 of the 43 inland lakes of Isle Royale National Park, the largest island in Lake Superior, contain northen pike with mercury concentrations exceeding health conxumption advisory levels (> 500 ng/g ww). Standard length (550 mm) pike in advisory lake...

  3. Dialogue and Community in Online Learning: Lessons from Royal Roads University

    ERIC Educational Resources Information Center

    Guilar, Joshua; Loring, Alice

    2008-01-01

    This study used a grounded theory case study to identify the theoretical areas that account for the nature and success of Royal Roads University's (RRU) learning community model. This instructional model enables RRU's mission to serve adult learners who want to further their careers through education while living and working across British…

  4. Finding the Way: Improving Access to the Collections of the Royal Scottish Geographical Society

    ERIC Educational Resources Information Center

    Fenton, Candida

    2007-01-01

    Purpose: The purpose of this paper is to describe the Images for All digitisation project at the Royal Scottish Geographical Society, and lessons learned from it. Design/methodology/approach: This paper describes the background to the project and collections held. It focuses on the development of the project web site, the digitisation of 100…

  5. Build Your Own Particle Smasher: The Royal Society Partnership Grants Scheme

    ERIC Educational Resources Information Center

    Education in Science, 2012

    2012-01-01

    This article features the project, "Build Your Own Particle Smasher" and shares how to build a particle smasher project. A-level and AS-level students from Trinity Catholic School have built their own particle smashers, in collaboration with Nottingham Trent University, as part of The Royal Society's Partnership Grants Scheme. The…

  6. Reflections on a Degree Initiative: The UK's Birmingham Royal Ballet Dancers Enter the University of Birmingham

    ERIC Educational Resources Information Center

    Benn, Tansin

    2003-01-01

    This paper provides an opportunity to share experiences and perceptions of the first 5 years of a degree programme for professional dancers. A partnership developed in the mid-1990s between the UK's Birmingham Royal Ballet and the University of Birmingham, Westhill (now School of Education), to provide a part-time, post-experience, flexible study…

  7. Build Your Own Particle Smasher: The Royal Society Partnership Grants Scheme

    ERIC Educational Resources Information Center

    Education in Science, 2012

    2012-01-01

    This article features the project, "Build Your Own Particle Smasher" and shares how to build a particle smasher project. A-level and AS-level students from Trinity Catholic School have built their own particle smashers, in collaboration with Nottingham Trent University, as part of The Royal Society's Partnership Grants Scheme. The…

  8. Co-Operative Problem-Solving at the Royal Docks Community School

    ERIC Educational Resources Information Center

    Martin, Ruth

    2013-01-01

    This article responds to Henry Tam's article in this issue of FORUM by exploring opportunities for co-operative problem-solving for staff and students of the Royal Docks Community School in the London Borough of Newham. Becoming a co-operative trust helped the school move out of special measures and develop a strategy of participation and…

  9. The William Houston Gold Medal of the Royal College of Surgeons of Edinburgh 2009.

    PubMed

    Flint, Helen E

    2010-12-01

    As part of the Membership in Orthodontics examination, candidates are required to present five treated cases. Two of the cases treated by one of the winners of the William Houston Gold Medal from the MOrth diet of the Royal College of Surgeons of Edinburgh in 2009 are described.

  10. Wolf research in the Isle Royale wilderness: do the ends justify the means?

    Treesearch

    Jack G. Oelfke; Rolf O. Peterson; John A. Vucetich; Leah M. Vucetich

    2000-01-01

    Isle Royale National Park is a remote island ecosystem in Lake Superior. A long-term research program investigating the wolf and moose populations in the Park has provided the public and scientific community with valuable information on the ecology of these species in this wilderness setting. A persistent decline within the wolf population led to a change in the...

  11. The William Houston Gold Medal of the Royal College of Surgeons of Edinburgh 2014, orthodontic cases.

    PubMed

    Almuzian, Mohammed

    2015-09-01

    The William Houston Medal is awarded to the individual achieving the highest mark at, the Membership in Orthodontics (MOrth) examination at the Royal College of Surgeons of Edinburgh. As part of the examination the candidate must submit five clinical cases. Details of two cases treated by the winning candidate are presented in this paper.

  12. Leadership Roles and Responsibilities in Operationalizing the Royal Commission: A Special Education Perspective.

    ERIC Educational Resources Information Center

    McBride, Shirley

    1990-01-01

    The Director of Special Education for British Columbia reviews developments of the past year arising out of the Royal Commission on Education's report including specific legislative changes, changes in the role of the Special Education Branch, in the funding of education, and the fiscal framework. Eight priorities for the year ahead are…

  13. APPARENT 85KRYPTON AGES OF GROUNDWATER WITHIN THE ROYAL WATERSHED, MAINE, USA

    EPA Science Inventory

    85Kr activities were determined in 264 domestic and municipal wells from 2002-2004 in the Royal watershed (361 km2), Maine. Gas extraction for 85Kr from wells was effected directly via a well-head methodology permitting efficient widespread analys...

  14. Fluidized bed boiler at the Royal Alexandra Hospital for Children, Camperdown.

    PubMed

    Ellis, J W

    1985-03-01

    A fluidized bed boiler has been installed at the Royal Alexandra Hospital for Children, Camperdown, N.S.W. This paper describes the reasons for developing a project to demonstrate that a fluidized bed coal fire combustor can be incorporated with a modern packaged steam boiler. The boiler and combustor are of Australian design as suitable proven designs from overseas were not available.

  15. FRONT RIGHT OBLIQUE VIEW, SHOWING FRONT WALK/STEPS AND ROYAL PALM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FRONT RIGHT OBLIQUE VIEW, SHOWING FRONT WALK/STEPS AND ROYAL PALM IN FOREGROUND. VIEW FACING NORTH - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Four-Bedroom, Single-Family Type 10, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  16. Early examples of art in Scottish hospitals, 1: Edinburgh Royal Hospital for Sick Children.

    PubMed

    Park, Maureen

    2003-09-01

    The artist Phoebe Traquair was commissioned to decorate a mortuary chapel for Edinburgh's Royal Hospital for Sick Children. This article is the first of two which look at examples of art created for, and in, Scottish hospitals in the 19th century. It is suggested that the importance of Scotland's contribution to this movement is unrecognized by many of its modern-day practitioners.

  17. From Sun King to Royal Twilight: Painting in Eighteenth Century France from the Musee Picardie, Amiens.

    ERIC Educational Resources Information Center

    Johnson, Mark M.

    2000-01-01

    Focuses on the traveling exhibition from the Musee de Picardie in Amiens, France, called "From the Sun King to the Royal Twilight: Painting in Eighteenth Century France," that provides an overview of French paintings from the reign of Louis IV to the fall of the monarchy. (CMK)

  18. Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria

    USDA-ARS?s Scientific Manuscript database

    The antibacterial activity of royalisin, an antimicrobial peptide from the royal jelly produced by honeybees has been addressed extensively. However, its mechanism of action remains unclear. In this study, a recombinant royalisin, RAcc-royalisin from the royal jelly of Chinese honeybee Apis cerana...

  19. MRJP microsatellite markers in Africanized Apis mellifera colonies selected on the basis of royal jelly production.

    PubMed

    Parpinelli, R S; Ruvolo-Takasusuki, M C C; Toledo, V A A

    2014-08-28

    It is important to select the best honeybees that produce royal jelly to identify important molecular markers, such as major royal jelly proteins (MRJPs), and hence contribute to the development of new breeding strategies to improve the production of this substance. Therefore, this study focused on evaluating the genetic variability of mrjp3, mrjp5, and mrjp8 and associated allele maintenance during the process of selective reproduction in Africanized Apis mellifera individuals, which were chosen based on royal jelly production. The three loci analyzed were polymorphic, and produced a total of 16 alleles, with 4 new alleles, which were identified at mrjp5. The effective number of alleles at mrjp3 was 3.81. The observed average heterozygosity was 0.4905, indicating a high degree of genetic variability at these loci. The elevated FIS values for mrjp3, mrjp5, and mrjp8 (0.4188, 0.1077, and 0.2847, respectively) indicate an excess of homozygotes. The selection of Africanized A. mellifera queens for royal jelly production has maintained the mrjp3 C, D, and E alleles; although, the C allele occurred at a low frequency. The heterozygosity and FIS values show that the genetic variability of the queens is decreasing at the analyzed loci, generating an excess of homozygotes. However, the large numbers of drones that fertilize the queens make it difficult to develop homozygotes at mrjp3. Mating through instrumental insemination using the drones of known genotypes is required to increase the efficiency of Africanized A. mellifera-breeding programs, and to improve the quality and efficiency of commercial royal jelly apiaries.

  20. Anti-inflammatory effects of royal jelly on ethylene glycol induced renal inflammation in rats.

    PubMed

    Aslan, Zeyneb; Aksoy, Laçine

    2015-01-01

    In this study, anti-inflammatory effects of Royal Jelly were investigated by inducing renal inflammation in rats with the use of ethylene glycol. For this purpose, the calcium oxalate urolithiasis model was obtained by feeding rats with ethylene glycol in drinking water. The rats were divided in five study groups. The 1st group was determined as the control group. The rats in the 2nd group received ethylene glycol (1%) in drinking water. The rats in the 3rd group were daily fed with Royal Jelly by using oral gavage. The 4th group was determined as the preventive group and the rats were fed with ethylene glycol (1%) in drinking water while receiving Royal Jelly via oral gavage. The 5th group was determined as the therapeutic group and received ethylene glycol in drinking water during the first 2 weeks of the study and Royal Jelly via oral gavage during the last 2 weeks of the study. At the end of the study, proinflammatory/anti-inflammatory cytokines, TNF-a, IL-1ß and IL-18 levels in blood and renal tissue samples from the rats used in the application were measured. The results have shown that ethylene glycol does induce inflammation and renal damage. This can cause the formation of reactive oxygen species. Royal Jelly is also considered to have anti-inflammatory effects due to its possible antiradical and antioxidative effects. It can have positive effects on both the prevention of urolithiasis and possible inflammation during the existing urolithiasis and support the medical treatment.

  1. Netherlands Hydrological Modeling Instrument - Unifying Dutch hydrological modeling expertise for national policy analysis

    NASA Astrophysics Data System (ADS)

    Delsman, J.; Kukuric, N.; Veldhuizen, A.; Tiktak, A.; Kroon, T.

    2009-04-01

    Dutch hydrological institutes Alterra, Deltares, Netherlands Environmental Assessment Agency and RWS Waterdienst have cooperated to build a new national hydrological model. The instrument will be used by all three ministries involved in national water policy matters, for instance drought management, manure policy and climate change issues. The basis of the modeling instrument is a state-of-the-art on-line coupling of the groundwater system (MODFLOW) and the unsaturated zone (metaSWAP). Optionally a national surface water module (MOZART-DM) can be added, in which surface water distribution, discharge and supply are accounted for. The data for the instrument is derived from several national databases, including the subsoil, groundwater abstractions, topsoil, land use, drainage, water distribution, water management and meteorological data. The Netherlands Hydrological modeling Instrument will be the center point of a framework of models, to coherently model the hydrological system and the multitude of functions it supports. This framework will assist in national policy making. Our ambition is to also make the instrument suitable on a regional and local water board scale. Therefore, for the future refinement of the model, local knowledge of hydrological system needs to be implemented in cooperation with the water boards. The development of the new Netherlands Hydrological modeling Instrument is a quality boost for national water management, thanks to a unique cooperation of all major research institutes and policy makers. It constitutes an essential instrument in implementing the right policy in a changing climate.

  2. Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody.

    PubMed

    Shen, Li-rong; Wang, Yi-ran; Zhai, Liang; Zhou, Wen-xiu; Tan, Liang-liang; Li, Mei-lu; Liu, Dan-dan; Xiao, Fa

    2015-02-01

    Major royal jelly protein 1 (MRJP1), designated apalbumin 1, has been regarded as a freshness marker of royal jelly (RJ). A MRJP1-specific peptide (IKEALPHVPIFD) identified by bioinformatics analysis of homologous members of the major royal protein family was synthesized and used to raise polyclonal anti-MRJP1 antibody (anti-SP-MRJP1 antibody). Western blot analysis showed that anti-SP-MRJP1 antibody only reacted with MRJP1 in RJ. In contrast, the previously reported antibody against recombinant MRJP1 (anti-R-MRJP1 antibody) reacted with other members of MRJP family in RJ. Enzyme-linked immunosorbent assay (ELISA) using anti-SP-MRJP1 antibody demonstrated that MRJP1 content in RJ stored at 40 °C significantly degraded by 37.3%, 55.9%, 58.0%, 60.6%, 65.7%, 72.7%, and 73.1% at 7, 14, 21, 28, 35, 42, and 49 d, respectively, when compared with MRJP1 content in fresh RJ (0 d). Optical density analysis of MRJP bands from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles demonstrated that the degradation of MRJP1, MRJP2, MRJP3, and MRJP5 in RJ was strongly and positively correlated with the period of storage (P<0.0001). Our results indicated anti-SP-MRJP1 antibody was highly specific for MRJP1, and ELISA using the antibody is a sensitive and easy-to-use method to determine the freshness and authenticity of RJ.

  3. Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1, major royal jelly protein 1 antibody*

    PubMed Central

    Shen, Li-rong; Wang, Yi-ran; Zhai, Liang; Zhou, Wen-xiu; Tan, Liang-liang; Li, Mei-lu; Liu, Dan-dan; Xiao, Fa

    2015-01-01

    Major royal jelly protein 1 (MRJP1), designated apalbumin 1, has been regarded as a freshness marker of royal jelly (RJ). A MRJP1-specific peptide (IKEALPHVPIFD) identified by bioinformatics analysis of homologous members of the major royal protein family was synthesized and used to raise polyclonal anti-MRJP1 antibody (anti-SP-MRJP1 antibody). Western blot analysis showed that anti-SP-MRJP1 antibody only reacted with MRJP1 in RJ. In contrast, the previously reported antibody against recombinant MRJP1 (anti-R-MRJP1 antibody) reacted with other members of MRJP family in RJ. Enzyme-linked immunosorbent assay (ELISA) using anti-SP-MRJP1 antibody demonstrated that MRJP1 content in RJ stored at 40 °C significantly degraded by 37.3%, 55.9%, 58.0%, 60.6%, 65.7%, 72.7%, and 73.1% at 7, 14, 21, 28, 35, 42, and 49 d, respectively, when compared with MRJP1 content in fresh RJ (0 d). Optical density analysis of MRJP bands from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles demonstrated that the degradation of MRJP1, MRJP2, MRJP3, and MRJP5 in RJ was strongly and positively correlated with the period of storage (P<0.0001). Our results indicated anti-SP-MRJP1 antibody was highly specific for MRJP1, and ELISA using the antibody is a sensitive and easy-to-use method to determine the freshness and authenticity of RJ. PMID:25644470

  4. Religious Education in the Secularised Netherlands

    ERIC Educational Resources Information Center

    van Dijk-Groeneboer, Monique C. H.

    2017-01-01

    Being a religious educator in Western Europe, especially in the highly secularised Netherlands, is a complicated job. There are concepts to be taught to a generation that is mostly religiously analphabetic. Religion is subject to many discussions that foremost include the media's coverage of extremist versions of religion. It has become more…

  5. Childcare in the Netherlands: Lessons in Privatisation

    ERIC Educational Resources Information Center

    Akgunduz, Yusuf Emre; Plantenga, Janneke

    2014-01-01

    In 2005 the Child Care Act was introduced in the Netherlands. The explicit objective of the childcare reform has been to stimulate the operation of market forces so that childcare services are provided in an efficient way. The change towards a demand-driven financing system implies that there is no longer public provision of childcare services in…

  6. Rural Youth Culture: "Keten" in the Netherlands

    ERIC Educational Resources Information Center

    Haartsen, Tialda; Strijker, Dirk

    2010-01-01

    A remarkable present-day phenomenon in rural areas in the Netherlands is that young people, mostly males, often meet in small groups in self-built or at least self-fitted out sheds or caravans ("keten"). At first glance, these "keten" seem to be substitutes for more official entertainment sites in the relatively sparsely…

  7. Compact Geography of the Netherlands. (Third Edition).

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    This document presents information on the physical and human geography of the Netherlands. In this third revised edition, the contents have been brought up-to-date and expanded. In addition, sections on physical planning and environmental problems have been added. The booklet is intended for use by geography classroom teachers and students at…

  8. Islamic Primary Schools in the Netherlands

    ERIC Educational Resources Information Center

    Dronkers, Jaap

    2016-01-01

    During the last 20 years of the 20th century, Islamic primary schools were founded in the Netherlands thanks to its constitutional "freedom of education" (which allows state-funded religious schools), its voucher system (each school receives the same amount of money per pupil), and school choice by parents. This essay gives some…

  9. Rural Youth Culture: "Keten" in the Netherlands

    ERIC Educational Resources Information Center

    Haartsen, Tialda; Strijker, Dirk

    2010-01-01

    A remarkable present-day phenomenon in rural areas in the Netherlands is that young people, mostly males, often meet in small groups in self-built or at least self-fitted out sheds or caravans ("keten"). At first glance, these "keten" seem to be substitutes for more official entertainment sites in the relatively sparsely…

  10. Education and Diversity in the Netherlands

    ERIC Educational Resources Information Center

    Leeman, Yvonne

    2008-01-01

    This article sets out the Dutch approach to the multicultural question. It focuses on how national policies, schools, teachers and teacher educators are addressing and making sense of questions of cultural and religious diversity. The article shows how the Netherlands has partly accommodated itself to greater cultural diversity through compulsory…

  11. Education and Diversity in the Netherlands

    ERIC Educational Resources Information Center

    Leeman, Yvonne

    2008-01-01

    This article sets out the Dutch approach to the multicultural question. It focuses on how national policies, schools, teachers and teacher educators are addressing and making sense of questions of cultural and religious diversity. The article shows how the Netherlands has partly accommodated itself to greater cultural diversity through compulsory…

  12. Treponemal infections in hares in The Netherlands.

    PubMed Central

    Lumeij, J T; de Koning, J; Bosma, R B; van der Sluis, J J; Schellekens, J F

    1994-01-01

    Treponemal infections in wild European brown hares (Lepus europaeus) from The Netherlands were diagnosed by means of serological tests for human syphilis and histological demonstration of spirochetes by the Bosma-Steiner silver impregnation method in histological sections of skin lesions. The treponeme should probably be classified as "Treponema paraluisleporis." Images PMID:8150971

  13. Islamic Primary Schools in the Netherlands

    ERIC Educational Resources Information Center

    Dronkers, Jaap

    2016-01-01

    During the last 20 years of the 20th century, Islamic primary schools were founded in the Netherlands thanks to its constitutional "freedom of education" (which allows state-funded religious schools), its voucher system (each school receives the same amount of money per pupil), and school choice by parents. This essay gives some…

  14. Compact Geography of the Netherlands. (Third Edition).

    ERIC Educational Resources Information Center

    Information and Documentation Centre for the Geography of the Netherlands, Utrecht.

    This document presents information on the physical and human geography of the Netherlands. In this third revised edition, the contents have been brought up-to-date and expanded. In addition, sections on physical planning and environmental problems have been added. The booklet is intended for use by geography classroom teachers and students at…

  15. Effective School Improvement in the Netherlands

    ERIC Educational Resources Information Center

    Sun, Hechuan; de Jong, Rob

    2007-01-01

    Purpose: The purpose of this study is to find out what kind of contextual factors that positively or negatively influence effective school improvement (ESI) in The Netherlands. Design/methodology/approach: To achieve the above-mentioned purpose, Sun's contextual level model with ten contextual factors and 48 indicators has been used to carefully…

  16. HIV transmission patterns among The Netherlands, Suriname, and The Netherlands Antilles: a molecular epidemiological study.

    PubMed

    Kramer, Merlijn A; Cornelissen, Marion; Paraskevis, Dimitrios; Prins, Maria; Coutinho, Roel A; van Sighem, Ard I; Sabajo, Lesley; Duits, Ashley J; Winkel, Cai N; Prins, Jan M; van der Ende, Marchina E; Kauffmann, Robert H; Op de Coul, Eline L

    2011-02-01

    We aimed to study patterns of HIV transmission among Suriname, The Netherlands Antilles, and The Netherlands. Fragments of env, gag, and pol genes of 55 HIV-infected Surinamese, Antillean, and Dutch heterosexuals living in The Netherlands and 72 HIV-infected heterosexuals living in Suriname and the Antilles were amplified and sequenced. We included 145 pol sequences of HIV-infected Surinamese, Antillean, and Dutch heterosexuals living in The Netherlands from an observational cohort. All sequences were phylogenetically analyzed by neighbor-joining. Additionally, HIV-1 mobility among ethnic groups was estimated. A phylogenetic tree of all pol sequences showed two Surinamese and three Antillean clusters of related strains, but no clustering between ethnic groups. Clusters included sequences of individuals living in Suriname and the Antilles as well as those who have migrated to The Netherlands. Similar clustering patterns were observed in env and gag. Analysis of HIV mobility among ethnic groups showed significantly lower migration between groups than expected under the hypothesis of panmixis, apart from higher HIV migration between Antilleans in The Netherlands and all other groups. Our study shows that HIV transmission mainly occurs within the ethnic group. This suggests that cultural factors could have a larger impact on HIV mobility than geographic distance.

  17. "NEVER REGARD YOURSELF AS ALREADY SO THOROUGHLY INFORMED": THE WITHDRAWAL OF ITS INVITATION TO RODNEY SYME TO ADDRESS ITS 2015 CONGRESS BY THE ROYAL AUSTRALASIAN COLLEGE OF PHYSICIANS.

    PubMed

    Parker, Malcolm; Kerridge, Ian; Komesaroff, Paul

    2015-09-01

    In 1628, William Harvey presented his revolutionary theory of the circulation to ears at the Royal College of Physicians that had been deafened by the unquestionable authority of Galen's teachings, from one and a half millennia in the past. Harvey's theory was initially rejected, despite his faith in his colleagues being eager for truth and knowledge, and never regarding themselves as so well informed that they would not welcome "further information". Recently Rodney Syme, the retired Melbourne urologist who for a long time has agitated for the legalisation of assisted dying, and also challenged the authorities to apply the current law in response to his admitted assistance to a number of individuals, was invited to address the 2015 Congress of the Royal Australasian College of Physicians. At the eleventh hour, the invitation to speak was withdrawn. In this column, we trace the course of events leading to this withdrawal of the invitation, and describe some of the correspondence to and from the College in response to the withdrawal. We draw parallels between the experiences of Harvey and Syme, and point to lessons to be learnt from the recent episode of apparent unwillingness, on the part of an institution that seeks to present itself as outward-looking, progressive and socially aware, to fulfil this promise in the increasingly important area of the end-of-life.

  18. J.G. Crowther's War: Institutional strife at the BBC and British Council.

    PubMed

    Jones, Allan

    2016-06-01

    Science writer, historian and administrator J.G. Crowther (1899-1983) had an uneasy relationship with the BBC during the 1920s and 1930s, and was regarded with suspicion by the British security services because of his left politics. Nevertheless the Second World War saw him working for 'establishment' institutions. He was closely associated with the BBC's Overseas Service and employed by the British Council's Science Committee. Both organizations found Crowther useful because of his wide, international knowledge of science and scientists. Crowther's political views, and his international aspirations for the British Council's Science Committee, increasingly embroiled him in an institutional conflict with the Royal Society and with its president, Sir Henry Dale, who was also chairman of the British Council's Science Committee. The conflict centred on the management of international scientific relations, a matter close Crowther's heart, and to Dale's. Dale considered that the formal conduct of international scientific relations was the Royal Society's business rather than the British Council's. Crowther disagreed, and eventually resigned from the British Council Science Committee in 1946. The article expands knowledge of Crowther by drawing on archival documents to elucidate a side of his career that is only lightly touched on in his memoirs. It shows that 'Crowther's war' was also an institutional war between the Science Committee of the British Council and the Royal Society. Crowther's unhappy experience of interference by the Royal Society plausibly accounts for a retreat from his pre-war view that institutional science should plan and manage BBC science broadcasts.

  19. Music Confucius Institute: Evaluating Its Approach as an Agent for International Chinese Music Dissemination

    ERIC Educational Resources Information Center

    Guo, Wei; Li, Sheng Bing

    2016-01-01

    The paper identifies the educational and presentational functions of the Confucius Institute (MCI) at the Royal Danish Academy of Music (RDAM) as its core approaches which mostly influence Chinese cultural dissemination in its host country. The MCI's utilization of the two dissemination approaches aligns with the "receiver-centered"…

  20. Implementing evidence-based policy in a network setting: road safety policy in the Netherlands.

    PubMed

    Bax, Charlotte; de Jong, Martin; Koppenjan, Joop

    2010-01-01

    In the early 1990s, in order to improve road safety in The Netherlands, the Institute for Road Safety Research (SWOV) developed an evidence-based "Sustainable Safety" concept. Based on this concept, Dutch road safety policy, was seen as successful and as a best practice in Europe. In The Netherlands, the policy context has now changed from a sectoral policy setting towards a fragmented network in which safety is a facet of other transport-related policies. In this contribution, it is argued that the implementation strategy underlying Sustainable Safety should be aligned with the changed context. In order to explore the adjustments needed, two perspectives of policy implementation are discussed: (1) national evidence-based policies with sectoral implementation; and (2) decentralized negotiation on transport policy in which road safety is but one aspect. We argue that the latter approach matches the characteristics of the newly evolved policy context best, and conclude with recommendations for reformulating the implementation strategy.

  1. End-of-life decisions in newborns: an approach from The Netherlands.

    PubMed

    Verhagen, A A E; Sauer, P J J

    2005-09-01

    End-of-life decisions in newborns with incurable conditions are especially difficult for pediatricians if they regard the group of stable infants with a hopeless prognosis, not dependent on technology. If a life full of severe and sustained suffering that cannot be relieved by any other means is expected, deliberate ending of life can be an acceptable choice in the Netherlands under very strict conditions. To increase the quality of the decision-making process and facilitate the mandatory reporting of life-ending procedures, a set of medical and legal guidelines (the Groningen protocol) was made in our institution in collaboration with the district attorney. This protocol serves as a tool to bring newborn euthanasia under a regime of effective control. This article describes the present approach to life-ending measures in newborns in the Netherlands and gives an overview of the protocol.

  2. Similar problems, different solutions: comparing refuse collection in the Netherlands and Spain.

    PubMed

    Bel, Germà; Fageda, Xavier; Dijkgraaf, Elbert; Gradus, Raymond

    2010-01-01

    Because of differences in institutional arrangements, public service markets, and national traditions regarding government intervention, local public service provision can vary greatly. In this paper we compare the procedures adopted by the local governments of The Netherlands and Spain in arranging for the provision of solid waste collection. We find that Spain faces a problem of consolidation, opting more frequently to implement policies of privatization and cooperation, at the expense of competition. By contrast, The Netherlands, which has larger municipalities on average, resorts somewhat less to privatization and cooperation, and more to competition. Both options-cooperation and competition-have their merits when striving to strike a balance between transaction costs and scale economies. The choices made in organizational reform seem to be related to several factors, among which the nature of the political system and the size of municipalities appear to be relevant.

  3. Institution Morphisms

    NASA Technical Reports Server (NTRS)

    Goguen, Joseph; Rosu, Grigore; Norvig, Peter (Technical Monitor)

    2001-01-01

    Institutions formalize the intuitive notion of logical system, including both syntax and semantics. A surprising number of different notions of morphisim have been suggested for forming categories with institutions as objects, and a surprising variety of names have been proposed for them. One goal of this paper is to suggest a terminology that is both uniform and informative to replace the current rather chaotic nomenclature. Another goal is to investigate the properties and interrelations of these notions. Following brief expositions of indexed categories, twisted relations, and Kan extensions, we demonstrate and then exploit the duality between institution morphisms in the original sense of Goguen and Burstall, and the 'plain maps' of Meseguer, obtaining simple uniform proofs of completeness and cocompleteness for both resulting categories; because of this duality, we prefer the name 'comorphism' over 'plain map.' We next consider 'theoroidal' morphisms and comorphisims, which generalize signatures to theories, finding that the 'maps' of Meseguer are theoroidal comorphisms, while theoroidal morphisms are a new concept. We then introduce 'forward' and 'semi-natural' morphisms, and appendices discuss institutions for hidden algebra, universal algebra, partial equational logic, and a variant of order sorted algebra supporting partiality.

  4. Institutional Censorship

    ERIC Educational Resources Information Center

    Burke, John Gordon; Bowers, H. Paxton

    1970-01-01

    The difficulty an individual who has been denied access to library material faces in obtaining a remedy in the courts dictates that the library profession go on record against all forms of institutional censorship or unreasonable restrictions on use of library materials. (Author/JS)

  5. Institutional Paralysis

    ERIC Educational Resources Information Center

    Yarmolinsky, Adam

    1975-01-01

    Institutional paralysis of higher education is the result of the disjunction between faculty and administration; the disjunction between substantive planning and bugetary decision-making; the disjunction between departmental structures and functional areas of university concern; and the disjunction between the theory of direct democracy and its…

  6. Institutional Change.

    ERIC Educational Resources Information Center

    Smith, Hayden R., Ed.

    1978-01-01

    This publication's theme, "Institutional Change," is broadly examined in fourteen articles that range from research and opinion to allegory and satire. A student teacher, a dean, and a state education director are among the authors. Articles concern: 1) key elements of change; 2) relationships between local, county, state, and federal educational…

  7. Institutional betrayal.

    PubMed

    Smith, Carly Parnitzke; Freyd, Jennifer J

    2014-09-01

    A college freshman reports a sexual assault and is met with harassment and insensitive investigative practices leading to her suicide. Former grade school students, now grown, come forward to report childhood abuse perpetrated by clergy, coaches, and teachers--first in trickles and then in waves, exposing multiple perpetrators with decades of unfettered access to victims. Members of the armed services elect to stay quiet about sexual harassment and assault during their military service or risk their careers by speaking up. A Jewish academic struggles to find a name for the systematic destruction of his people in Nazi Germany during the Holocaust. These seemingly disparate experiences have in common trusted and powerful institutions (schools, churches, military, government) acting in ways that visit harm upon those dependent on them for safety and well-being. This is institutional betrayal. The purpose of this article is to describe psychological research that examines the role of institutions in traumatic experiences and psychological distress following these experiences. We demonstrate the ways in which institutional betrayal has been left unseen by both the individuals being betrayed as well as the field of psychology and introduce means by which to identify and address this betrayal.

  8. Dealing with risk of fixed installations in The Netherlands

    NASA Astrophysics Data System (ADS)

    Ale, B. J. M.

    In a densely populated and highly industrialized country such as The Netherlands, the competent authorities face the problem of making sure that, on the one hand, the chemical industry can develop and, on the other, the population is not subjected to undue risk or nuisance. Cryogenic storage facilities are treated just as other industrial facilities would be in this respect. While up to the early 1970s such planning was done on the basis of qualitative insight into the hazards of chemical plants, since then it has been recognized that global insight and engineering judgement alone no longer form a solid enough basis on which to rest safety decisions, such as changes to an installation, siting and zoning. From the mid-1970s the Directorate General for the Environment in The Netherlands has been developing tools to support decision makers with quantified information about risks. The development of these techniques has been a complicated task in which the Directorate worked together with engineering companies and the research institutions of the EEC. The development of more accurate tools is a continuing process. The application of decision support techniques to areas other than the immediate risks to life, such as carcinogenic effects and ecological damage, may need even more work to develop suitable techniques. The Directorate General for the Environment has also developed preliminary guidelines for the acceptability of risk. The application of quantitative techniques to support decisions with respect to potentially hazardous chemical installations has been accepted by Parliament. Since the introduction of the Major Hazards Regulation more than 50 external safety reports, describing the risks of major chemical complexes, have been produced. These reports give an interesting insight into the risks of these types of installations and the necessary safety zones around them. They also give an indication to what sort of information can be used successfully by the

  9. Simultaneous determination of seven fluoroquinolones in royal jelly by ultrasonic-assisted extraction and liquid chromatography with fluorescence detection.

    PubMed

    Zhou, Jinhui; Xue, Xiaofeng; Chen, Fang; Zhang, Jinzhen; Li, Yi; Wu, Liming; Chen, Lanzhen; Zhao, Jing

    2009-04-01

    A method for the quantitative determination of seven fluoroquinolone antibacterial agents (FQs) used in beekeeping, viz. ciprofloxacin, norfloxacin, ofloxacin, pefloxacin, danofloxacin, enrofloxacin, and difloxacin, in royal jelly samples was developed on the basis of high performance liquid chromatography with fluorescence detection. Sample preparation included deproteination, ultrasonic-assisted extraction with a mixed inorganic solution of monopotassium phosphate (KH(2)PO(4)) and ethylenediaminetetraacetic acid disodium salt (Na(2)EDTA), and clean-up on a solid-phase extraction cartridge. The extraction procedure was optimized with regard to the amount of inorganic solvent and the duration of sonication for royal jelly as a complicated matrix. Overall recoveries for FQs ranged from 85.9 to 99.1% for royal jelly with standard deviations between 2.79 and 6.27%. Limits of quantification were 2-40 ng/g for seven FQs in royal jelly. A total of 57 real royal jelly samples collected from beekeepers and supermarkets were analyzed. The three most abundant honeybee-use FQs, i. e. ofloxacin, ciprofloxacin, and norfloxacin, were determined in some royal jelly samples in concentrations ranging from 11.9 to 55.6 ng/g. Unexpectedly, however, difloxacin was found at concentrations of about 46.8 ng/g in one sample although it is rarely used in beekeeping. The presented method was successfully applied to quantify FQs in real royal jelly samples.

  10. Identification of genes related to high royal jelly production in the honey bee (Apis mellifera) using microarray analysis.

    PubMed

    Nie, Hongyi; Liu, Xiaoyan; Pan, Jiao; Li, Wenfeng; Li, Zhiguo; Zhang, Shaowu; Chen, Shenglu; Miao, Xiaoqing; Zheng, Nenggan; Su, Songkun

    2017-10-02

    China is the largest royal jelly producer and exporter in the world, and high royal jelly-yielding strains have been bred in the country for approximately three decades. However, information on the molecular mechanism underlying high royal jelly production is scarce. Here, a cDNA microarray was used to screen and identify differentially expressed genes (DEGs) to obtain an overview on the changes in gene expression levels between high and low royal jelly producing bees. We developed a honey bee gene chip that covered 11,689 genes, and this chip was hybridised with cDNA generated from RNA isolated from heads of nursing bees. A total of 369 DEGs were identified between high and low royal jelly producing bees. Amongst these DEGs, 201 (54.47%) genes were up-regulated, whereas 168 (45.53%) were down-regulated in high royal jelly-yielding bees. Gene ontology (GO) analyses showed that they are mainly involved in four key biological processes, and pathway analyses revealed that they belong to a total of 46 biological pathways. These results provide a genetic basis for further studies on the molecular mechanisms involved in high royal jelly production.

  11. The Role of IMAT Solutions for Training Development at the Royal Netherlands Air Force. IMAT Follow-up Research Part 1

    DTIC Science & Technology

    2005-09-01

    are prevented . 3.1.3 Organisational Memory Tool The general purpose of the organisational memory tool is to assist users in the process of creating...steps of a user in a directive manner and prevents a user from making mistakes as much as possible. The next figure gives an example of one of the steps...FunctiorWl knowledige of systerm x 8].. Being able to perform all preventive maintenance tasks• E• To perform Vap~ection tasks SDeclarative knowledge about

  12. Observing the skies of Lisbon. Isaac de Sequeira Samuda, an estrangeirado in the Royal Society.

    PubMed

    Vieira, Carla Costa

    2014-06-20

    Elected in 1723, Isaac de Sequeira Samuda (1681-1729) was the first Jewish Fellow of the Royal Society. He had arrived in London just a few years earlier, escaping from the Portuguese Inquisition. Despite his past, he had no difficulty in establishing links with his country's diplomatic representatives in London. A physician and adviser on scientific subjects, he became a conduit between the emerging world of Portuguese astronomy and the British scientific community. He reported to the Royal Society on astronomical observations made in the new observatories in Lisbon and helped with the acquisition of scientific instruments and books destined for Portugal. These activities were facets of Samuda's unusual career and the diverse though often converging associations that he established until his death. As the member of a network active in the diffusion of new ideas and in the modernization of Portuguese science, Samuda can be regarded as an estrangeirado, as this term has come to be used in the modern literature.

  13. Organochlorine and metal residues in royal terns nesting on the central Texas coast

    USGS Publications Warehouse

    King, K.A.; LeFever, C.A.; Mulhern, B.M.

    1983-01-01

    Royal Tern eggs collected from Pelican and Sundown islands on the central Texas coast in 1978 contained relatively low levels of organochlorine and metal pollutants. DDE and PCBs were found most frequently, but levels were below those known to have an adverse effect on avian reproduction and survival. Average metal residues did not vary significantly between study areas, and with the possible exception of mercury, were present only at background levels. Shells of eggs collected in 1978 were no thinner than eggshells collected before 1947. There was a significant imporvement in mean eggshell thickness from 1970 to 1978 and a corresponding decline in DDE and PCB residues. No deformed or abnormal young were observed. Although elevated levels of industrial contaminants were reported in sediments and sea grasses of Corpus Christi Bay, little of those contaminants appear to have accumulated in the Royal Tern.

  14. Sir William Burnett (1779-1861), professional head of the Royal Naval Medical Department and entrepreneur.

    PubMed

    Penn, Christopher

    2004-08-01

    Sir William Burnett (1779-1861) had an active career as a Royal Navy surgeon in the French Revolutionary and Napoleonic Wars, including service at the battles of St Vincent, the Nile and Trafalgar. From 1822 to 1855 he was professional head of the Royal Naval Medical Department, when he provided effective leadership in a time of great change. Although his official work earned him the reputation of a "hard-working, unimaginative, somewhat harsh man", his correspondence shows a very humane centre under the official carapace. His official performance and reputation were both eroded towards the end of his career by his determined promotion of zinc chloride, for which he held lucrative patents.

  15. The zoonotic implications of pentastomiasis in the royal python (python regius).

    PubMed

    Ayinmode, Ab; Adedokun, Ao; Aina, A; Taiwo, V

    2010-09-01

    Pentastomes are worm-like endoparasites of the phylum Pentastomida found principally in the respiratory tract of reptiles, birds, and mammals. They cause a zoonotic disease known as pentastomiasis in humans and other mammals. The autopsy of a Nigerian royal python (Python regius) revealed two yellowish-white parasites in the lungs, tissue necrosis and inflammatory lesions. The parasite was confirmed to be Armillifer spp (Pentastomid); this is the first recorded case of pentastomiasis in the royal python (Python regius) in Nigeria. This report may be an alert of the possibility of on-going zoonotic transmission of pentastomiasis from snake to man, especially in the sub-urban/rural areas of Nigeria and other West African countries where people consume snake meat.

  16. Death and the dead-house in Victorian asylums: necroscopy versus mourning at the Royal Edinburgh Asylum, c. 1832–1901

    PubMed Central

    Andrews, Jonathan

    2014-01-01

    This article examines the management and meaning of post-mortem examinations, and the spatial ordering of patients’ death, dissection and burial at the Victorian asylum, referencing a range of institutional contexts and exploiting a case study of the Royal Edinburgh Asylum. The routinizing of dissection and the development of the dead-house from a more marginal asylum sector to a lynchpin of laboratory medicine is stressed. External and internal pressure to modernize pathological research facilities is assessed alongside governmental, public and professional critiques of variable necroscopy practices. This is contextualized against wider issues and attitudes surrounding consent and funereal rituals. Onus is placed on tendencies in anatomizing insanity towards the conversion of deceased lunatics – pauper lunatics especially – into mere pathological specimens. On the other hand, significant but compromised resistance on the part of a minority of practitioners, relatives and the wider public is also identified. PMID:22701924

  17. The End of Alchemy? The Repudiation and Persistence of Chrysopoeia at the Académie Royale des Sciences in the Eighteenth Century.

    PubMed

    Principe, Lawrence M

    2014-01-01

    The general abandonment of serious endeavor toward metallic transmutation represents a major development in the history of chemistry, yet its exact causes and timing remain unclear. This essay examines the fate of chrysopoeia at the eighteenth-century Académie Royale des Sciences. It reveals a long-standing tension between Académie chemists, who pursued transmutation, and administrators, who tried to suppress it. This tension provides background for Etienne-François Geoffroy's 1722 paper describing fraudulent practices around transmutation. Although transmutation seems to disappear after Geoffroy's paper, manuscripts reveal that most of the institution's chemists continued to pursue it privately until at least the 1760s, long after widely accepted dates for the "demise of alchemy" in learned circles.

  18. A report from the inaugural meeting of the British Neurosurgical Trainee Research Collaborative held in the Royal College of Surgeons of England, 19 October 2012.

    PubMed

    Kolias, Angelos G; Jones, Timothy L; Cowie, Christopher J; Coulter, Ian C; Afshari, Fardad T; Tarnaris, Andrew; Nelson, Richard J; Gray, William P; Hutchinson, Peter J; Brennan, Paul M

    2013-06-01

    Clinical research, which is essential for improving patient outcomes, is increasingly carried out in the context of networks established between multiple institutions. Research is also considered an important component of training curricula. The recent successful completion of a randomised trial (ROSSINI), which was led by general surgical trainees of the West Midlands Research Collaborative, has established the feasibility of trainee collaborative research networks. A research network for neurosurgical trainees in the UK and Ireland was, therefore, established following the meeting of the British Neurosurgical Trainee Association (BNTA) in Aberdeen on 19 April 2012. This BNTA initiative quickly gained the full support from the Society of British Neurological Surgeons and the UK Neurosurgical Research Network. The inaugural meeting of the British Neurosurgical Trainee Research Collaborative took place at the Royal College of Surgeons of England, London, on 19 October 2012. The purpose of this report is both to record progress to date and to promote this concept.

  19. Large-scale preparation of glycopeptides harboring the TF-antigen unit from royal jelly.

    PubMed

    Maeda, Megumi; Tanaka, Tatsuya; Kimura, Mariko; Kimura, Yoshinobu

    2014-01-01

    We have reported that new N-glycans carrying the TF-antigen occurred on a major royal jelly glycoprotein, and we have identified the glycosylation site to which the antigenic N-glycan is linked, but an appropriate procedure has not been established to prepare non-labeled immunoreactive glycopeptides in large amounts for functional analysis. In this study, we developed an effective method of preparing Asn-glycopeptide bearing TF-antigen.

  20. The Royal Medical Society of Edinburgh: Sale of its Library at Sotheby's *

    PubMed Central

    Crawford, Helen

    1970-01-01

    The library of the Royal Medical Society of Edinburgh, which has been in existence for nearly 250 years, was sold by Sotheby & Co. of London at three auction sales during 1969. The author describes her attendance at the three sales, with emphasis on the most valuable items sold and the considerable acquisitions made for the Middleton Medical Library of the University of Wisconsin. Concluding observations concern some of the practical problems of acquiring antiquarian books at auction. Images PMID:5496237

  1. Technological Advancements in EW: A Way Forward for Royal Saudi Naval Force

    DTIC Science & Technology

    2013-09-01

    Middle East and North Africa MSBU Military system business unit MODA Ministry of Defense and Aviation MBET Missile borne ECM technology NEWAC NATO...organized under the Ministry of Defence and Aviation ( MODA ) to defend the Kingdom against any external aggression. The RSNF is an operational force of... MODA . Another force, the Saudi Arabian National Guard, is responsible for maintaining the internal stability of the Kingdom. The Royal Saudi Naval

  2. [Health care in the prisons of the Kingdom. General Royal Ordinance of prisons of 1834].

    PubMed

    Leiva-Tapia, J

    2015-01-01

    In the 19th century, the concept of "prison health" began to make an appearance in Spanish legislation as an integral part of prison management. Thanks to a series of ideological and progressive principles in the same century, laws were decreed and regulated to address the need for adequate medical care for prisoners in Africa, Spain and the overseas territories. The most important of these was the Royal Ordinance of Prisoners of the Kingdom of 1834, and subsequent Regulation of 1844.

  3. Conscientious care for the unconscious patient: new guidance from the Royal College of Physicians.

    PubMed

    Wade, Derick

    2014-06-01

    Patients who remain unconscious and unaware after a brain insult challenge healthcare. Clinicians are faced with a clinical situation often outside their usual experience. Organisations are faced with practical issues concerning resource use. And people, especially family and friends, are faced with moral, legal and philosophical questions that have no easy answers. This conference launched national guidelines that should assist clinical teams and organisations, and should ensure that all patients and families receive a good quality service. © 2014 Royal College of Physicians.

  4. Incidence of Boxing Injuries in the Royal Air Force in the United Kingdom 1953—66

    PubMed Central

    Brennan, T. N. N.; O'Connor, P. J.

    1968-01-01

    Statistics of injuries arising in amateur boxing in the Royal Air Force in the 14 years 1953-66 are given. There were 240 injuries including two deaths in the 14 years. During the seven years 1960-66, four men out of every thousand entering the ring received injuries to the head or neck which kept them off work for 48 hours or more. No case of the punch-drunk syndrome was seen. PMID:5723355

  5. Heat Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer.

    PubMed

    Moriyama, Takanori; Ito, Aimi; Omote, Sumire; Miura, Yuri; Tsumoto, Hiroki

    2015-01-01

    Soluble royal jelly protein is a candidate factor responsible for mammiferous cell proliferation. Major royal jelly protein 1 (MRJP1), which consists of oligomeric and monomeric forms, is an abundant proliferative protein in royal jelly. We previously reported that MRJP1 oligomer has biochemical heat resistance. Therefore, in the present study, we investigated the effects of several heat treatments (56, 65 and 96°C) on the proliferative activity of MRJP1 oligomer. Heat resistance studies showed that the oligomer molecular forms were slightly maintained until 56℃, but the molecular forms were converted to macromolecular heat-aggregated MRJP1 oligomer at 65℃ and 96℃. But, the growth activity of MRJP1 oligomer treated with 96°C was slightly attenuated when compared to unheated MRJP1 oligomer. On the other hand, the cell proliferation activity was preserved until 96℃ by the cell culture analysis of Jurkat cells. In contrast, those of IEC-6 cells were not preserved even at 56°C. The present observations suggest that the bioactive heat-resistance properties were different by the origin of the cells. The cell proliferation analysis showed that MRJP1 oligomer, but not MRJP2 and MRJP3, significantly increased cell numbers, suggesting that MRJP1 oligomer is the predominant proliferation factor for mammiferous cells.

  6. Evaluation and review of the safety management system implementation in the Royal Thai Air Force

    NASA Astrophysics Data System (ADS)

    Chaiwan, Sakkarin

    This study was designed to determine situation and effectiveness of the safety management system currently implemented in the Royal Thai Air Force. Reviewing the ICAO's SMS and the RTAF's SMS was conducted to identify similarities and differences between the two safety management systems. Later, the researcher acquired safety statistics from the RTAF Safety Center to investigate effectiveness of its safety system. The researcher also collected data to identify other factors affecting effectiveness of the safety system during conducting in-depth interviews. Findings and Conclusions: The study shows that the Royal Thai Air Force has never applied the International Civil Aviation Organization's Safety management System to its safety system. However, the RTAF's SMS and the ICAO's SMS have been developed based on the same concepts. These concepts are from Richard H. Woods's book, Aviation safety programs: A management handbook. However, the effectiveness of the Royal Thai Air Force's safety system is in good stance. An accident rate has been decreasing regularly but there are no known factors to describe the increasing rate, according to the participants' opinion. The participants have informed that there are many issues to be resolved to improve the RTAF's safety system. Those issues are cooperation among safety center's staffs, attitude toward safety of the RTAF senior commanders, and safety standards.

  7. Life history variation among four lake trout morphs at Isle Royale, Lake Superior

    USGS Publications Warehouse

    Hansen, Michael J.; Nate, Nancy A.; Muir, Andrew M.; Bronte, Charles R.; Zimmerman, Mara S.; Krueger, Charles C.

    2016-01-01

    Life history traits were compared among four morphs of lake trout at Isle Royale, Lake Superior. Of 738 lake trout caught at Isle Royale, 701 were assigned to a morph (119 humpers, 160 leans, 85 redfins, and 337 siscowets) using a combination of statistical analysis of head and body shape and visual assignment. On average, redfins were longer (544 mm), heavier (1,481 g), heavier at length (Wr = 94), more buoyant, and older (22 years) than siscowets (519 mm; 1,221 g; 90; 19 years), leans (479 mm; 854 g; 82; 13 years), and humpers (443 mm; 697 g; 87; 17 years). On average, leans grew from a younger age at length = 0 and shorter length at age = 0, at a faster early growth rate to a longer asymptotic length than the other three morphs, while redfins grew at a slower instantaneous rate and humpers grew to a shorter asymptotic length than other morphs. On average, leans were longer (562 mm) and older (15 years) at 50% maturity than redfins (427 mm, 12 years), siscowets (401 mm, 11 years), or humpers (394 mm, 13 years). Life history parameters did not differ between males and females within each morph. We conclude that differences in life history attributes of lean, humper, redfin, and siscowet morphs of lake trout are consistent with differential habitat use in waters around Isle Royale, Lake Superior.

  8. Relation of environmental factors to breeding status of royal and sandwich terns in South Carolina, USA

    USGS Publications Warehouse

    Blus, L.J.; Prouty, R.M.; Neely, B.S.

    1979-01-01

    The population ecology of the royal tern Sterna maxima and sandwich tern Sterna sandvicensis was investigated in South Carolina from 1970 through 1977. Royal and sandwich terns nested together in all of the colonies that we located. The peak in egg laying usually occurred in early May; peak hatching occurred from late May to mid-June. Clutch size for both species was one egg. Tidal flooding was the major factor in egg loss. The breeding population was 15,499 pairs in 1974 and 18,096 pairs in 1975; sandvicensis made up about 5% of the breeding population. The average number of young fledged per nest ranged from 0?36 to 0?44. Residues of organochlorine pollutants in most eggs and tissues were low and posed no identifiable threat to the terns. There was a decline in DDE and dieldrin residues in eggs of maxima. The future of royal and sandwich terns in South Carolina seems fairly secure as the population is apparently at or near carrying capacity and most of the major nesting sites are dedicated to protection of nesting birds.

  9. Her Royal Highness Princess Maha Chakri Sirindhorn: her activities in humanity and medicine.

    PubMed

    Chauluxananan, Somrat; Chentanez, Vilai

    2005-09-01

    Her Royal Highness Princess Maha Chakri Sirindhorn, the Executive Vice-President of the Thai Red Cross Society has followed the footsteps of her fore-bears, carrying the noble humanitarian work they began, particularly the work of the Thai Red Cross society and the Faculty of Medicine, Chulalongkorn University. Her contributions have been a benefit to all, and she has earned great love and is held in high esteem by her people. Her ideas, thoughts, words, and activities have been of immense value to the faculty in both tangible and intangible ways. A selfless, dedicated women who is willing to make sacrifices for the common good, Her Royal Highness serves as a model humanitarian for the staff of the Faculty of Medicine, Chulalongkorn University, whose morale she has boosted and whose operations she has planned with the foresight ofa first-class administrator. Her devotion to the Thai Red Cross, and thus her devotion to her people, have indeed made her the royal gem within Thai hearts, with sparkling brilliance of her humanitarian deeds instilling the warmth of her love in our spirits.

  10. Heat Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer

    PubMed Central

    Moriyama, Takanori; Ito, Aimi; Omote, Sumire; Miura, Yuri; Tsumoto, Hiroki

    2015-01-01

    Soluble royal jelly protein is a candidate factor responsible for mammiferous cell proliferation. Major royal jelly protein 1 (MRJP1), which consists of oligomeric and monomeric forms, is an abundant proliferative protein in royal jelly. We previously reported that MRJP1 oligomer has biochemical heat resistance. Therefore, in the present study, we investigated the effects of several heat treatments (56, 65 and 96°C) on the proliferative activity of MRJP1 oligomer. Heat resistance studies showed that the oligomer molecular forms were slightly maintained until 56℃, but the molecular forms were converted to macromolecular heat-aggregated MRJP1 oligomer at 65℃ and 96℃. But, the growth activity of MRJP1 oligomer treated with 96°C was slightly attenuated when compared to unheated MRJP1 oligomer. On the other hand, the cell proliferation activity was preserved until 96℃ by the cell culture analysis of Jurkat cells. In contrast, those of IEC-6 cells were not preserved even at 56°C. The present observations suggest that the bioactive heat-resistance properties were different by the origin of the cells. The cell proliferation analysis showed that MRJP1 oligomer, but not MRJP2 and MRJP3, significantly increased cell numbers, suggesting that MRJP1 oligomer is the predominant proliferation factor for mammiferous cells. PMID:26020775

  11. Use of Royal Darwin Hospital emergency department by immigration detainees in 2011.

    PubMed

    Deans, Adrienne K; Boerma, Clare J; Fordyce, James; De Souza, Mark; Palmer, Didier J; Davis, Joshua S

    2013-12-16

    To describe the number and nature of emergency department (ED) attendances by immigration detainees in Darwin, in the Northern Territory, over a 12-month period. Retrospective observational study of immigration detainees attending the Royal Darwin Hospital ED during the 2011 calendar year. Number of ED attendances and primary diagnoses. In 2011, there were 770 ED attendances by 518 individual detainees at Royal Darwin Hospital. Those who attended the ED had a mean (SD) age of 27.6 (12.2) years, and 112 of them (21.6%) were children. Most (413, 79.7%) were male, and Iran and Afghanistan were the two most common countries of birth. We estimate that 50.1% (95% CI, 47.0%-53.2%) of immigration detainees in Darwin (mean, 776 per month; total, 1034), attended the Royal Darwin Hospital ED at least once in 2011. The most common primary diagnosis was psychiatric problems (187 attendances, 24.3%), including self-harm (138 attendances, 17.9%). In 2011, asylum seekers in immigration detention in Darwin had a high prevalence of unmet health needs and substantial levels of psychiatric morbidity. The primary health care provided to them was inadequate.

  12. The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series*

    PubMed Central

    Siavash, Mansour; Shokri, Saeideh; Haghighi, Sepehr; Mohammadi, Mahbubeh; Shahtalebi, Mohammad Ali; Farajzadehgan, Ziba

    2011-01-01

    BACKGROUND: Foot ulcers and infections are the major sources of morbidity in individuals with diabetes mellitus. This study aimed to evaluate the efficacy of topical Royal Jelly (a worker honey bee product) on healing diabetic foot ulcers. METHODS: Diabetic patients with foot ulcers that were referred to our clinic at Khorshid Hospital, Isfahan, Iran; were evaluated three times a week and treated according to standard treatments consisted of offloading, infection control, vascular improvement and debridement if required. In addition, all ulcers were measured and then topical sterile 5% Royal Jelly was applied on the total surface area of the wounds. Eventually, they were covered with sterile dressings. Each patient was followed for a period of three months or until the complete healing. RESULTS: A total of eight patients were enrolled in this study. Of these, two had two ulcers and, therefore, ten ulcers were evaluated. Two ulcers were excluded. Seven of the remained eight ulcers healed. Mean duration of complete healing was 41 days. One ulcer did not completely heal but improved to 40% smaller in length, 32% in width and 28% in depth. The mean length, width and depth reduction rates were 0.35 mm/day, 0.28 mm/day and 0.11 mm/day, respectively. CONCLUSIONS: Royal Jelly dressing may be an effective method for treating diabetic foot ulcers besides standard treatments. PMID:22279458

  13. Major royal jelly proteins as markers of authenticity and quality of honey.

    PubMed

    Bilikova, Katarina; Kristof Krakova, Tatiana; Yamaguchi, Kikuji; Yamaguchi, Yoshihisa

    2015-12-01

    Until now, the properties of honey have been defined based exclusively on the content of plant components in the nectar of given plant. We showed that apalbumin1, the major royal jelly (RJ) protein, is an authentic and regular component of honey. Apalbumin1 and other RJ proteins and peptides are responsible for the immunostimulatory properties and antibiotic activity of honey. For the quantification of apalbumin1, an enzyme-linked immunosorbent assay (ELISA) was developed using polyclonal anti-apalbumin1 antibody. The method is suitable for honey authenticity determination; moreover it is useful for detection of the honey, honeybee pollen and RJ in products of medicine, pharmacy, cosmetics, and food industry, where presences of these honeybee products are declared. Results from the analysis for presence and amount of apalbumin1 in honeys will be used for high-throughput screening of honey samples over the world. On the basis of our experiments which show that royal jelly proteins are regular and physiologically active components of honey we propose to change the definition of honey (according to the EU Honey Directive 2001/110/EC) as follows: Honey is a natural sweet substance produced by honey bees from nectar of plants or from secretions of plants, or excretions of plant sucking insects, which honey bees collect, transform by combining with major royal jelly proteins and other specific substances of their own, deposit, dehydrate, store and leave in the honey comb to ripen and mature.

  14. Effect of storage under extremely low oxygen on the volatile composition of 'Royal Gala' apples.

    PubMed

    Both, Vanderlei; Brackmann, Auri; Thewes, Fabio Rodrigo; Ferreira, Daniele de Freitas; Wagner, Roger

    2014-08-01

    The aim of this work was to assess the profile of volatile compounds in 'Royal Gala' apples stored under controlled atmosphere (CA), with O(2) levels ranging from 1.0kPa to as low as 0.5kPa during 8months (0.5°C), followed by 7days of shelf-life at 20°C. Volatile compounds were collected via solid-phase microextraction (HS-SPME) and analysed by gas chromatography. Straight and branched-chain esters exhibited a distinct pattern. The emission of straight-chain esters decreased under extremely low O(2) (0.5kPa), while branched-chain esters were not significantly affected in such condition. 2-Methyl-butyl acetate, a significant contributor to the 'Royal Gala' aroma, was higher in intermediate O(2) concentration, suggesting that lowering the O(2) levels down to 0.7kPa does not negatively affect the volatile composition of 'Royal Gala' apples, as compared to the standard CA (1.0kPa O(2)). The remaining volatile compounds were not strongly affected by storing fruits under extremely low O(2). Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. [Climate change and health in the Netherlands].

    PubMed

    Huynen, Maud M T E; van Vliet, Arnold J H

    2009-01-01

    Climate change possibly affects public health in the Netherlands, including changes in (a) temperature-related effects, heat stress and air pollution, (b) allergies, (c) vector borne infectious disease, and (d) food- and waterborne infectious disease. Due to many prevailing uncertainties, opinions differ regarding the exact size of the expected health risks and the speed at which these might occur, as well as regarding to what degree society would need to or could adapt to these potential health effects. Thus, the gaps in our knowledge are substantial. Scientists and experts are clearly concerned about the limited amount of attention being paid to health effects of climate change in the Netherlands. In response, a proposal for a research programme 'Klimaatverandering en Gezondheid' ('Climate change and health') has been developed over the past year.

  16. Odontology and the history of medicine at the Royal Society of Medicine 1907-1960 and the contributions of Lilian Lindsay--Part One. The early years of the Royal Society of Medicine and the Section of Odontology.

    PubMed

    Papworth, Julie

    2014-01-01

    This paper examines the foundation of the Royal Society of Medicine and the Sections of Odontology. It considers the remarkable achievements of Lilian Lindsay which were made at a time when the medical world was almost entirely dominated by men.

  17. Medical use of cannabis in the Netherlands.

    PubMed

    Gorter, Robert W; Butorac, Mario; Cobian, Eloy Pulido; van der Sluis, Willem

    2005-03-08

    The authors investigated the indications for cannabis prescription in the Netherlands and assessed its efficacy and side effects. A majority (64.1%) of patients reported a good or excellent effect on their symptoms. Of these patients, approximately 44% used cannabis for >/=5 months. Indications were neurologic disorders, pain, musculoskeletal disorders, and cancer anorexia/cachexia. Inhaled cannabis was perceived as more effective than oral administration. Reported side effects were generally mild.

  18. The construction of a Central Netherlands temperature

    NASA Astrophysics Data System (ADS)

    van der Schrier, G.; van Ulden, A.; van Oldenborgh, G. J.

    2011-05-01

    The Central Netherlands Temperature (CNT) is a monthly daily mean temperature series constructed from homogenized time series from the centre of the Netherlands. The purpose of this series is to offer a homogeneous time series representative of a larger area in order to study large-scale temperature changes. It will also facilitate a comparison with climate models, which resolve similar scales. From 1906 onwards, temperature measurements in the Netherlands have been sufficiently standardized to construct a high-quality series. Long time series have been constructed by merging nearby stations and using the overlap to calibrate the differences. These long time series and a few time series of only a few decades in length have been subjected to a homogeneity analysis in which significant breaks and artificial trends have been corrected. Many of the detected breaks correspond to changes in the observations that are documented in the station metadata. This version of the CNT, to which we attach the version number 1.1, is constructed as the unweighted average of four stations (De Bilt, Winterswijk/Hupsel, Oudenbosch/Gilze-Rijen and Gemert/Volkel) with the stations Eindhoven and Deelen added from 1951 and 1958 onwards, respectively. The global gridded datasets used for detecting and attributing climate change are based on raw observational data. Although some homogeneity adjustments are made, these are not based on knowledge of local circumstances but only on statistical evidence. Despite this handicap, and the fact that these datasets use grid boxes that are far larger then the area associated with that of the Central Netherlands Temperature, the temperature interpolated to the CNT region shows a warming trend that is broadly consistent with the CNT trend in all of these datasets. The actual trends differ from the CNT trend up to 30 %, which highlights the need to base future global gridded temperature datasets on homogenized time series.

  19. [Euthanasia and palliative care in the Netherlands].

    PubMed

    Boisseau, Nicolas

    2004-03-27

    THE BIRTH OF THE DUTCH LAW: Euthanasia has been recently legalized in the Netherlands (since April 1, 2002). In this Article, we present the various cultural and historical factors that contributed to the law, the guidelines for the procedure and the resulting controversy. THE INTERVENING FACTORS: Internationally, the attitude concerning end of life care are heterogenic and also directly depend on religious and cultural factors. In the Netherlands, the health system promotes the maintenance at home of the terminally ill. However, the financial aspects (private health insurance) interact with the management of these patients. The rules for euthanasia are very strict and a declaration must be registered. Dedicated commissions are organised to control that the rules are applied. The current debate concerns the pertinence of the regulations, the attitude towards handicapped people and children, and the need to develop palliative care. The latter have only recently been developed in the country. The priority is focusing on old peoples' homes. The Netherlands is slow in this regard, but a new draft law is soon to be presented to the Authorities, and will most probably enable the gaps to be bridged.

  20. Gene therapy legislation in The Netherlands.

    PubMed

    Bleijs, D A; Haenen, I T W C; Bergmans, J E N

    2007-10-01

    Several regulatory organisations are involved in the assessment of clinical gene therapy trials involving genetically modified organisms (GMOs) in The Netherlands. Medical, ethical and scientific aspects are, for instance, evaluated by the Central Committee on Research Involving Human Subjects (CCMO). The Ministry of Housing, Spatial Planning and the Environment (VROM) is the competent authority for the environmental risk assessment according to the deliberate release Directive 2001/18/EC. A Gene Therapy Office has been established in order to streamline the different national review processes and to enable the official procedures to be completed as quickly as possible. Although the Gene Therapy Office improved the application process at the national level, there is a difference of opinion between the EU member states with respect to the EU Directive according to which gene therapy trials are assessed, that urges for harmonisation. This review summarises the gene therapy legislation in The Netherlands and in particular The Netherlands rationale to follow Directive 2001/18/EC for the environmental risk assessment.

  1. "Making a Mess in the Mud": The Discovery of Toddlers' Special Needs by Child Scientists in the 1930s in the Netherlands

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2012-01-01

    In this article, the author discusses plans that were launched at three consecutive conferences on care for toddlers between 1929 and 1938 in the Netherlands. These plans and their realisation are evaluated in terms of what was seen as the missing link in the supply of institutional care for young children. The author identifies the professional…

  2. The Impact of New Technologies on Occupational Profiles in the Banking Sector. Case Studies in Luxembourg, the Netherlands, the United Kingdom and France. CEDEFOP Panorama.

    ERIC Educational Resources Information Center

    Vitali, Laurence; Freiche, Jeanine; Matthews, Alison; Warmerdam, John

    The impact of new technologies on occupational profiles in the banking sector was examined through case studies in four European countries: Luxembourg, the Netherlands, the United Kingdom, and France. In each country, three types of banking institutions were studied: merchant (Eurobank); "counter" (universal) bank; and telebank (bank…

  3. Differences and Similarities in the Use of the Portfolio and Personal Development Plan for Career Guidance in Various Vocational Schools in The Netherlands

    ERIC Educational Resources Information Center

    Mittendorff, Kariene; Jochems, Wim; Meijers, Frans; den Brok, Perry

    2008-01-01

    In The Netherlands, a growing number of vocational education and training institutes are implementing competence-based approaches to learning, including new career guidance practices. These practices often involve instruments such as portfolios or personal development plans, and are aimed at supporting students in their search for a sense of…

  4. "Making a Mess in the Mud": The Discovery of Toddlers' Special Needs by Child Scientists in the 1930s in the Netherlands

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2012-01-01

    In this article, the author discusses plans that were launched at three consecutive conferences on care for toddlers between 1929 and 1938 in the Netherlands. These plans and their realisation are evaluated in terms of what was seen as the missing link in the supply of institutional care for young children. The author identifies the professional…

  5. Saltwater movement in the upper Floridan aquifer beneath Port Royal Sound, South Carolina

    USGS Publications Warehouse

    Smith, Barry S.

    1994-01-01

    Freshwater for Hilton Head Island, South Carolina, is supplied by withdrawals from the Upper Floridan aquifer. Freshwater for the nearby city of Savannah, Georgia, and for the industry that has grown adjacent to the city, has also been supplied, in part, by withdrawal from the Upper Floridan aquifer since 1885. The withdrawal of ground water has caused water levels in the Upper Floridan aquifer to decline over a broad area, forming a cone of depression in the potentiometric surface of the aquifer centered near Savannah. In 1984, the cone of depression extended beneath Hilton Head Island as far as Port Royal Sound. Flow in the aquifer, which had previously been toward Port Royal Sound, has been reversed, and, as a result, saltwater in the aquifer beneath Port Royal Sound has begun to move toward Hilton Head Island. The Saturated-Unsaturated Transport (SUTRA) model of the U.S. Geological Survey was used for the simulation of density-dependent ground-water flow and solute transport for a vertical section of the Upper Floridan aquifer and upper confining unit beneath Hilton Head Island and Port Royal Sound. The model simulated a dynamic equilibrium between the flow of seawater and freshwater in the aquifer near the Gyben-Herzberg position estimated for the period before withdrawals began in 1885; it simulated reasonable movements of brackish water and saltwater from that position to the position determined by chemical analyses of samples withdrawn from the aquifer in 1984, and it approximated hydraulic heads measured in the aquifer in 1976 and 1984. The solute-transport simulations indicate that the transition zone would continue to move toward Hilton Head Island even if pumping ceased on the island. Increases in existing withdrawals or additional withdrawals on or near Hilton Head Island would accelerate movement of the transition zone toward the island, but reduction in withdrawals or the injection of freshwater would slow movement toward the island, according to the

  6. An evaluation of the Royal Air Force helicopter search and rescue services in Britain with reference to Royal Air Force Valley 1980-1989.

    PubMed Central

    Liskiewicz, W J

    1992-01-01

    The Royal Air Force (RAF) operates a helicopter Search and Rescue (SAR) service in the United Kingdom and territorial waters; it also provides a similar service in several locations abroad. A 10-year retrospective study of the SAR helicopter service operating from the RAF base at Valley on the island of Anglesey in North Wales is presented, with national SAR statistics over a similar period provided for comparison. Analysis of records kept by SAR aircrew at RAF Valley shows that their assistance had been requested on 1490 occasions during the 10-year period studied; most of these requests were the result of incidents involving holidaymakers, particularly in the mountains or along the coast. The results illustrate the versatility and life-saving potential of a highly skilled and motivated service able to work in adverse weather and dangerous locations. In the light of current debate, the value of aeromedical evacuation of seriously ill patients using helicopters is discussed. PMID:1494160

  7. Canine Supply for Physical Security: An Analysis of the Royal Australian Air Force Military Working Dog Program

    DTIC Science & Technology

    2016-03-01

    PHYSICAL SECURITY: AN ANALYSIS OF THE ROYAL AUSTRALIAN AIR FORCE MILITARY WORKING DOG PROGRAM by Mark W. Powell March 2016 Thesis...AN ANALYSIS OF THE ROYAL AUSTRALIAN AIR FORCE MILITARY WORKING DOG PROGRAM 5. FUNDING NUMBERS 6. AUTHOR(S) Mark W. Powell 7. PERFORMING...increased demand on its physical security elements. Its military working dog (MWD) workforce is required to meet an inventory of 204 by end of year 2023 as

  8. Weapon in the wrong hands: strategic mismanagement and how the Royal Navy lost the thirteen American colonies.

    DTIC Science & Technology

    2016-05-10

    of an old foe and a new threat. A revitalized France allied with American colonists in full rebellion presented the Royal Navy with an enemy unsuited...foe and a new threat. A revitalized France allied with American colonists in full rebellion presented the Royal Navy with an enemy unsuited to...British naval power enjoyed a superior position on the world’s stage in 1763. France had suffered greatly and turned within to rebuild its forces

  9. [Creating a 'Germanic' public health: national-socialism, human genetics, and eugenics in the Netherlands].

    PubMed

    Snelders, Stephen

    2007-01-01

    The consequences of the uses of concepts of heredity in society and health care are not simply determined. This is demonstrated by a study of Dutch National Socialist doctors and biologists in the Second World War. During the German occupation of the Netherlands SS-biologist W.F.H. Stroër (1907-1979) and SS-doctor J.A. van der Hoeven (1912-1998) attempted to create a eugenic research and health care institute in the Netherlands. Heredity was accorded a key role in National Socialist plans for reorganization of Dutch health care. The ideas of the SS-eugenicists were closely related to those of leading geneticists and eugenicists in the Netherlands. Eugenic ideas were spread among all political ideologies. As late as November 1942 cooperation between the SS and non-Nazi geneticists was still discussed. The hardening of the political climate during the war created more explicit dividing lines between them. The SS-researchers did not believe in the existence of well-defined and separated races. They rejected a purely genetic determinism and advocated measures of social hygiene next to a positive and negative eugenics in the creation of a more healthy Germanic people and a purer race. Racial and genetic concepts were not exclusively translated into eugenic policies directed at human reproduction.

  10. 75 FR 57815 - Purified Carboxymethylcellulose From Finland, Mexico, Netherlands, and Sweden

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... COMMISSION Purified Carboxymethylcellulose From Finland, Mexico, Netherlands, and Sweden AGENCY: United... antidumping duty orders on purified carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden... antidumping duty orders on purified carboxymethylcellulose from Finland, Mexico, Netherlands, and Sweden...

  11. Genetic structure and diversity among brook trout from Isle Royale, Lake Nipigon, and three Minnesota tributaries of Lake Superior

    USGS Publications Warehouse

    Stott, Wendylee; Quinlan, Henry R.; Gorman, Owen T.; King, Timothy L.

    2010-01-01

    Brook trout Salvelinus fontinalis from Isle Royale, Michigan, three Minnesota tributaries of Lake Superior, and Lake Nipigon in Ontario were analyzed for genetic variation at 12 microsatellite DNA loci. Analysis of molecular variance, genetic distance measures, and cluster analysis were used to examine the diversity, gene flow, and relatedness among the samples. The diversity estimates for the samples from Isle Royale were similar to those for the samples collected from Minnesota tributaries of Lake Superior, and all estimates were lower than those reported in other studies of brook trout from eastern North America. Genetic differences were detected among the brook trout at Isle Royale, Lake Nipigon, and the Minnesota tributaries of Lake Superior. Further, the population in Tobin Harbor at the eastern end of Isle Royale was distinct from the populations from tributaries at the southwestern end of the island. The Minnesota tributary population formed a group that was genetically distinct from those from Isle Royale and Lake Nipigon. The Isle Royale population should be managed to preserve the genetic and phenotypic variation that distinguishes it from the other brook trout populations analyzed to date.

  12. Atypical speech and language development: a consensus study on clinical signs in the Netherlands.

    PubMed

    Visser-Bochane, Margot I; Gerrits, Ellen; van der Schans, Cees P; Reijneveld, Sijmen A; Luinge, Margreet R

    2017-01-01

    Atypical speech and language development is one of the most common developmental difficulties in young children. However, which clinical signs characterize atypical speech-language development at what age is not clear. To achieve a national and valid consensus on clinical signs and red flags (i.e. most urgent clinical signs) for atypical speech-language development in children from 1 to 6 years of age. A two-round Delphi study in the Netherlands with a national expert panel (n = 24) of speech and language therapists was conducted. The panel members responded to web-based questionnaires addressing clinical signs. Consensus was defined as ≥ 70% of the experts agreeing on an issue. The first round resulted in a list of 161 characteristics of atypical speech and language development. The second round led to agreement on 124 clinical signs and 34 red flags. Dutch national consensus concerns 17-23 clinical signs per age year for the description of an atypical speech-language development in young children and three to 10 characteristics per age year being red flags for atypical speech-language development. This consensus contributes to early identification and diagnosis of children with atypical speech-language development, awareness and research. © 2016 Royal College of Speech and Language Therapists.

  13. Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals?

    PubMed Central

    2012-01-01

    Background Revalidation for UK doctors is expected to be introduced from late 2012. For general practitioners (GPs), this entails collecting supporting information to be submitted and assessed in a revalidation portfolio every five years. The aim of this study was to explore the feasibility of GPs working in secure environments to collect supporting information for the Royal College of General Practitioners’ (RCGP) proposed revalidation portfolio. Methods We invited GPs working in secure environments in England to submit items of supporting information collected during the previous 12 months using criteria and standards required for the proposed RCGP revalidation portfolio and complete a GP issues log. Initial focus groups and initial and follow-up semi-structured face-to-face and telephone interviews were held to explore GPs’ views of this process. Quantitative and qualitative data were analysed using descriptive statistics and identifying themes respectively. Results Of the 50 GPs who consented to participate in the study, 20 submitted a portfolio. Thirty-eight GPs participated in an initial interview, nine took part in a follow-up interview and 17 completed a GP issues log. GPs reported difficulty in collecting supporting information for valid patient feedback, full-cycle clinical audits and evidence for their extended practice role(s) as sessional practitioners in the high population turnover custodial environment. Peripatetic practitioners experienced more difficulty than their institution based counterparts collating this evidence. Conclusions GPs working in secure environments may experience difficulties in collecting the newer types of supporting information for the proposed RCGP revalidation portfolio primarily due to their employment status within a non-medical environment and characteristics of the detainee population. Increased support from secure environment service commissioners and employers will be a prerequisite for these practitioners to

  14. Can GPs working in secure environments in England re-license using the Royal College of General Practitioners revalidation proposals?

    PubMed

    Coomber, Jane; Charlton, Rodger; Thistlethwaite, Jill E; England, Liz

    2012-12-20

    Revalidation for UK doctors is expected to be introduced from late 2012. For general practitioners (GPs), this entails collecting supporting information to be submitted and assessed in a revalidation portfolio every five years. The aim of this study was to explore the feasibility of GPs working in secure environments to collect supporting information for the Royal College of General Practitioners' (RCGP) proposed revalidation portfolio. We invited GPs working in secure environments in England to submit items of supporting information collected during the previous 12 months using criteria and standards required for the proposed RCGP revalidation portfolio and complete a GP issues log. Initial focus groups and initial and follow-up semi-structured face-to-face and telephone interviews were held to explore GPs' views of this process. Quantitative and qualitative data were analysed using descriptive statistics and identifying themes respectively. Of the 50 GPs who consented to participate in the study, 20 submitted a portfolio. Thirty-eight GPs participated in an initial interview, nine took part in a follow-up interview and 17 completed a GP issues log. GPs reported difficulty in collecting supporting information for valid patient feedback, full-cycle clinical audits and evidence for their extended practice role(s) as sessional practitioners in the high population turnover custodial environment. Peripatetic practitioners experienced more difficulty than their institution based counterparts collating this evidence. GPs working in secure environments may experience difficulties in collecting the newer types of supporting information for the proposed RCGP revalidation portfolio primarily due to their employment status within a non-medical environment and characteristics of the detainee population. Increased support from secure environment service commissioners and employers will be a prerequisite for these practitioners to enable them to re-license using the RCGP

  15. Specialist perioperative allergy clinic services in the UK 2016: Results from the Royal College of Anaesthetists Sixth National Audit Project.

    PubMed

    Egner, W; Cook, T; Harper, N; Garcez, T; Marinho, S; Kong, K L; Nasser, S; Thomas, M; Warner, A; Hitchman, J; Floss, K

    2017-10-01

    Guidelines for investigation of perioperative drug allergy exist, but the quality of services is unknown. Specialist perioperative anaphylaxis services were surveyed through the Royal College of Anaesthetists 6(th) National Audit Project. We compare self-declared UK practice in specialist perioperative allergy services with national recommendations. A SurveyMonkey™ questionnaire was distributed to providers of allergy services in the UK. Responses were assessed for adherence to the best practice recommendations of the British Society for Allergy and Clinical Immunology (BSACI), the Association of Anaesthetists of Great Britain and Ireland and the National Institute for Health and Care Excellence (NICE) Guidance on Drug Allergy-CG183. Over 1200 patients were evaluated in 44 centres annually. Variation in workload, waiting times, access, staffing and diagnostic approach was noted. Paediatric centres had the longest routine waiting times (most wait >13 weeks) in contrast to adult centres (most wait <12 weeks). Service leads are allergists/immunologists (91%) or anaesthetists (7%). Potentially important differences were seen in: testing repertoire [10/44 (23%) lacked BSACI compliant neuromuscular blocking agent (NMBA) panels and 17/44 (39%) lacked a NAP6-defined extended panel; many failed to screen all cases for chlorhexidine 19/44 (43%) or latex 21/44 (48%)], staffing [only 26/44 (59%) had specialist nurses and 18/44 (41%) an anaesthetist] and provision of information [18/44 (41%) gave immediate information in clinic and 5/44 (11%) sign-posted support groups]. Most centres were able to provide diagnostic challenges to antibiotics [40/44 (91%]) and local anaesthetics [41/44 (93%)]. Diagnostic testing is not harmonized, with marked variability in the NMBA panels used to identify safe alternatives. Chlorhexidine and latex are not part of routine testing in many centres. Poor access to services and patient information provision require attention. Harmonization of

  16. [Possible exposure to rabies in anamnesis: rabies advice in the Netherlands].

    PubMed

    Beaujean, D J M A; van Ouwerkerk, I M S; Timen, A; Burgmeijer, R J F; Vermeer de Bondt, P E; van Steenbergen, J E

    2008-03-01

    Anamnestic incidences of four patients have highlighted the potential risk ofexposure to rabies. The first patient was a 30-year-old woman who rescued a bat from the mouth of her dog; it bit her on the right wrist. In the Netherlands, bats may be infected with the Lyssa virus. The Preparedness and Response Unit (PRU) of the Centre for Infectious Disease Control (CIDC) advised human rabies immunoglobulin (HRIG) and a full vaccination programme. The second patient was a 37-year-old woman, who caught a 'sick' squirrel and was subsequently bitten on her left hand. The advice was not to use post exposure prophylaxis since rabies is not prevalent amongst squirrels in the Netherlands. The third patient, a 55-year-old man, was bitten on his right calf by a dog in Sri Lanka. He was treated with HRIG and given the full vaccination course. The fourth patient was a 14-month-old boy who was scratched on the face by a cat in Turkey. He immediately received the first vaccination and upon return to the Netherlands was treated with HRIG and the other vaccinations. All patients remained without symptoms. A structured approach for risk assessment of each potential rabies incident is possible. It requires balancing a number of criteria: the species of animal, the endemicity of rabies in a country, the observed health or vaccination status of an animal, whether the animal can be tested for rabies, if the exposure was provoked or unprovoked, the type of injury and its location on the body of the injured, and the time interval between administration of HRIG and vaccine. In the Netherlands all health care providers are expected to perform a proper risk assessment. They may seek advice from regional health departments (Municipal Health Services), who, in turn, can be assisted by the PRU. HRIG and vaccine are only provided by the National Vaccine Institute in Bilthoven.

  17. The marginal success of regulated competition policy in the Netherlands.

    PubMed

    Lieverdink, H

    2001-04-01

    In the second half of the 1980s the government in the Netherlands adopted a regulated competition policy as part of a comprehensive programme designed to restructure the health care system. The programme was a product of its social and political context, promoted by a group of political entrepreneurs and created to improve efficiency. Despite the initial political support and a long political debate the government had to acknowledge by 1992 that the restructuring would not take place. But changes fostered limited competition between sickness funds and more extensive competition in the small market for supplementary policies. This, however, has not led to sickness funds becoming powerful purchasers that forced hospitals and doctors to improve their efficiency. Rather, they compete for subscribers, become part of large insurance conglomerates, and market more supplementary options. Culturally, health care institutions have become more entrepreneurial, taken up more business concepts, and made the language of markets, products and consumer sovereignty more common. The impact of these changes on the health care system is still unknown, but they create pressure for more health care services, leaving the government with problems that equal those of the 1980s.

  18. Exploring Political Views on Synthetic Biology in the Netherlands.

    PubMed

    Rerimassie, Virgil

    2016-01-01

    Synthetic biology may be an important source of progress as well as societal and political conflict. Against this backdrop, several technology assessment organizations have been seeking to contribute to timely societal and political opinion-making on synthetic biology. The Rathenau Instituut, based in the Netherlands, is one of these organizations. In 2011, the institute organized a 'Meeting of Young Minds': a young people's debate between 'future synthetic biologists' and 'future politicians'. The former were represented by participants in the international Genetically Engineered Machines competition (iGEM), the latter by political youth organizations (PYOs) linked to Dutch political parties. The Rathenau Instituut found seven PYOs-including right wing, left wing, Green and Christian groups-willing to commit to an intensive process aimed at formulating a tentative partisan view on synthetic biology and discussing it with fellow PYOs and iGEM participants. Given the minimal amount of available data on how political parties understand synthetic biology, mapping the debate may provide valuable insights. In this article, I aim to provide such a mapping exercise and also to reflect on how and why the Rathenau Instituut organized the event.

  19. Historic Royal events and the male to female ratio at birth in the United Kingdom.

    PubMed

    Grech, Victor

    2015-08-01

    The male to female ratio of live births is expressed as the ratio of male live births divided by total live births (M/T). Factors which reduce M/T include toxins, stress and privation. Britain remains enamoured of the Monarchy. This study was carried out in order to ascertain whether Royal events influenced M/T in the UK. Live births were analysed in relation to the birth of Prince Charles (1948), the Coronation of Queen Elizabeth II (1952), the Silver Jubilee (1977), the wedding of Diana Spencer to Charles, Prince of Wales (July 1981), the birth of Prince William (1982), the death of Lady Diana (August 1997), the wedding of Kate Middleton to Prince William (2011) and the Golden Jubilee (2002). This study analysed 29,293,240 live births. There was a significant dip in M/T in the Coronation year (p=0.03). M/T dipped significantly in relation to the Royal Wedding, commencing a year before (p<0.0001). There were no significant M/T changes in relation to the Silver and Golden Jubilees. The birth of Prince William in 1982 resulted in a rise in M/T in the following year only (p=0.016). Analysis by quarter in relation to Lady Diana's death showed a decline in M/T 4-5 months later in the first quarter of 1998 (p=0.046). The anticipation and stress leading to the Coronation and Royal Wedding may have depressed M/T. Increased coital rates associated with exuberance in relation to Prince William's birth may have raised M/T. Lady Diana's death was temporally associated with a decline in M/T. Royalty events may affect M/T ratios in Britain. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Subcutaneous packing in royal Egyptian mummies dated from 18th to 20th dynasties.

    PubMed

    Saleem, Sahar N; Hawass, Zahi

    2015-01-01

    It has been widely disseminated in the literature that subcutaneous packing, as part of mummification, was not usually done until the 21st dynasty. We aimed to study by computed tomography (CT) if subcutaneous packing was part of mummification of royal Egyptians dated to 18th to 20th dynasties. We analyzed the 2- and 3-dimensional CT images of 13 royal mummies dated to circa 1550 to 1153 BC for presence of subcutaneous embalming materials. Among the studied mummies were Amenhotep III, Tutankhamun, Seti I, and Ramesses II. We reported the CT characters of any detected subcutaneous embalming materials and noted their impact on the morphology of the involved body part. We correlated the CT findings with the archeological literature. Computed tomographic images showed subcutaneous packing in 12 (92.3%) mummies; whereas the mummy that was previously known as "Thutmose I" showed no such evidence. Subcutaneous packing involved the faces (n = 11), necks (n = 4), torsos (n = 5), and/or extremities (n = 4) of the mummies. Subcutaneous filling materials showed variation in homogeneity and CT densities and they were likely composed of resin, bits of linen with resin, or other substances. Subcutaneous packing procedure succeeded in providing uniform full contour of the involved body regions without causing significant tissue damages. Subcutaneous packing procedure was used as part of mummification of royal Ancient Egyptians dated to 18th to 20th dynasties earlier than what was believed in archaeology. The Ancient Egyptian embalmers must have been skilled in dissection and possessed surgical tools that enabled them to perform this fine procedure.

  1. Mercury toxicity in livers of northern pike (Esox lucius) from Isle Royale, USA.

    PubMed

    Drevnick, Paul E; Roberts, Aaron P; Otter, Ryan R; Hammerschmidt, Chad R; Klaper, Rebecca; Oris, James T

    2008-04-01

    Many laboratory studies have documented that mercury can be toxic to fish, but it is largely unknown if mercury is toxic to fish in their natural environments. The objective of our study was to investigate the toxic effects of mercury on northern pike (Esox lucius) at Isle Royale, Michigan. In 124 northern pike from eight inland lakes, concentrations of total mercury in skin-on fillets ranged from 0.069 to 0.622 microg/g wet mass (wet wt). Concentrations of total mercury in livers increased exponentially compared with concentrations in fillets, to a maximum of 3.1 microg/g wet wt. Methylmercury constituted a majority of the mercury in livers with total mercury concentrations <0.5 microg/g wet wt, but declined to 28-51% of the mercury in livers with total mercury concentrations >0.5 microg/g wet wt. Liver color (absorbance at 400 nm) varied among northern pike and was positively related to liver total mercury concentration. The pigment causing variation in liver color was identified as lipofuscin, which results from lipid peroxidation of membranous organelles. An analysis of covariance revealed lipofuscin accumulation was primarily associated with mercury exposure, and this association obscured any normal accumulation from aging. We also documented decreased lipid reserves in livers and poor condition factors of northern pike with high liver total mercury concentrations. Our results suggest (i) northern pike at Isle Royale are experiencing toxicity at concentrations of total mercury common for northern pike and other piscivorous fish elsewhere in North America and (ii) liver color may be useful for indicating mercury exposure and effects in northern pike at Isle Royale and possibly other aquatic ecosystems and other fish species.

  2. Prevalence of Dupuytren disease in The Netherlands.

    PubMed

    Lanting, Rosanne; van den Heuvel, Edwin R; Westerink, Bram; Werker, Paul M N

    2013-08-01

    Dupuytren disease is a fibroproliferative disease of palmar fascias of the hand. The prevalence of Dupuytren disease and the association with potential risk factors have been the subject of several studies, although there is a paucity of such data from The Netherlands. To study the prevalence of Dupuytren disease, the authors drew a random sample of 1360 individuals, stratified by age, from the northern part of The Netherlands. Of this sample, 763 individuals aged 50 to 89 years participated in this cross-sectional study. The authors examined both hands for signs of Dupuytren disease, and a questionnaire was conducted to identify potential risk factors. The effects of these risk factors were investigated using logistic regression analysis. Additional analyses were performed to develop a logistic prediction model for the prevalence of Dupuytren disease. The prevalence of Dupuytren disease was 22.1 percent. Nodules and cords were seen in 17.9 percent, and flexion contractures were present in 4.2 percent of the study population. Prevalence increased with age, from 4.9 percent in participants aged 50 to 55 years to 52.6 percent among those aged 76 to 80 years. Men were more often affected than women; 26.4 percent versus 18.6 percent, respectively (p=0.007). Other significant risk factors were previous hand injury, excessive alcohol consumption, familial occurrence of Dupuytren disease, and presence of Ledderhose disease. The results show a high prevalence of Dupuytren disease in The Netherlands, particularly the nodular form. Using the developed logistic prediction model, the prevalence of Dupuytren disease can be estimated, based on the presence of significant risk factors. Risk, III.

  3. Nearshore habitat and fish community associations of coaster brook trout in Isle Royale, Lake Superior

    USGS Publications Warehouse

    Gorman, O.T.; Moore, S.A.; Carlson, A.J.; Quinlan, H.R.

    2008-01-01

    We characterized the nearshore habitat and fish community composition of approximately 300 km of shoreline within and adjacent to the major embayments of Isle Royale, Lake Superior. Sampling yielded 17 species, of which 12 were widespread and represented a common element of the Lake Superior fish community, including cisco Coregonus artedi, lake whitefish C. clupeaformis, round whitefish Prosopium cylindraceum, lake trout Salvelinus namaycush, rainbow smelt Osmerus mordax, lake chub Couesius plumbeus, longnose sucker Catostomus catostomus, white sucker C. commersonii, trout-perch Percopsis omiscomaycus, ninespine stickleback Pungitius pungitius, burbot Lota lota, and slimy sculpin Cottus cognatus. The presence of brook trout S. fontinalis in an embayment was associated with the common species of the Isle Royale nearshore fish community, particularly cisco, longnose sucker, and round whitefish. However, brook trout were present in only five embayments and were common only in Tobin Harbor. Most Isle Royale embayments had broadly overlapping ranges of nearshore habitats. Within embayments, fish were distributed along a habitat gradient from less-protected rocky habitat near the mouth to highly protected habitat with mixed and finer substrates at the head. Embayments with brook trout had greater mean protection from the open lake, greater variation in depth, greater mean cover, and higher mean frequencies of large substrates (cobble, boulder, and bedrock). Within those embayments, brook trout were associated with habitat patches with higher mean frequencies of small substrates (particularly sand and coarse gravel). Within Tobin Harbor, brook trout were associated with midembayment habitat and species assemblages, especially those locations with a mixture of sand, gravel, and cobble substrates, an absence of bedrock, and the presence of round whitefish, white sucker, and trout-perch. Comparison of embayments with the model, Tobin Harbor, showed that six embayments

  4. Royal Society reports on Science Base,' suggests five-year fellowships

    SciTech Connect

    Sweet, W.

    1992-12-01

    In October, Britain's Royal Society released its long-awaited report, 'The Future of the Science Base,' the product of an 18 month review of how the nation's basic research is organized and the factors that might make it more successful. The science base report has been treated with considerable respect in the United Kingdom. Its conclusions, which are related in this article, may be of interest to Americans, as many of the trends and dilemmas identified in this report are also found in the U.S. This article review the specific recommendations of the report and also lists demographic and funding information.

  5. Effect of royal jelly ingestion for six months on healthy volunteers

    PubMed Central

    2012-01-01

    Background Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans. Methods We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention. Results Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276). Conclusions Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects. PMID:22995464

  6. Fossilized nuclei and chromosomes reveal 180 million years of genomic stasis in royal ferns.

    PubMed

    Bomfleur, Benjamin; McLoughlin, Stephen; Vajda, Vivi

    2014-03-21

    Rapidly permineralized fossils can provide exceptional insights into the evolution of life over geological time. Here, we present an exquisitely preserved, calcified stem of a royal fern (Osmundaceae) from Early Jurassic lahar deposits of Sweden in which authigenic mineral precipitation from hydrothermal brines occurred so rapidly that it preserved cytoplasm, cytosol granules, nuclei, and even chromosomes in various stages of cell division. Morphometric parameters of interphase nuclei match those of extant Osmundaceae, indicating that the genome size of these reputed "living fossils" has remained unchanged over at least 180 million years-a paramount example of evolutionary stasis.

  7. Intraocular lens confusions: a preventable "never event" - The Royal Victorian Eye and Ear Hospital protocol.

    PubMed

    Zamir, Ehud; Beresova-Creese, Katarina; Miln, Linda

    2012-09-01

    Intraocular lens (IOL) confusions and errors are among the most common postoperative adverse events. Errors may occur at any stage from the decision to operate to the insertion of the IOL. The most common errors occur during IOL selection pre-operative preparation (anaesthesia given before recognition that the intended IOL is not available), or intraoperatively (wrong IOL implanted because of confusion in the operating room). We review the mechanisms of errors reported in the literature and describe the experience at The Royal Victorian Eye and Ear Hospital. We also describe the implementation of an error-detection protocol and provide qualitative data on its performance.

  8. Scientists of the Gwansang-gam, the Royal Observatory of Joseon Dynasty (1)

    NASA Astrophysics Data System (ADS)

    Nha, Il-Seong; Nha, Sarah; Cho, Haman

    2013-03-01

    We have uncovered 14 Korean royal astronomers and one scientist who worked in the early and mid-18th century. In spite of their high positions in the government office, all of them but one were not recorded anywhere in the major histories, such as WangjoSillok (王朝實錄) and JeungboMunheonBigo (增補文獻備考). Our search of Bon'gwans for each person has been carried successfully for 13 scientists. Their family relations are also uncovered finding five eminent astronomy families.

  9. The Royal Naval Medical Services: delivering medical operational capability. the 'black art' of Medical Operational Planning.

    PubMed

    Faye, M

    2013-01-01

    This article looks to dispel the mysteries of the 'black art' of Medical Operational Planning whilst giving an overview of activity within the Medical Operational Capability area of Medical Division (Med Div) within Navy Command Headquarters (NCHQ) during a period when the Royal Naval Medical Services (RNMS) have been preparing and reconfiguring medical capability for the future contingent battle spaces. The rolling exercise program has been used to illustrate the ongoing preparations taken by the Medical Operational Capability (Med Op Cap) and the Medical Force Elements to deliver medical capability in the littoral and maritime environments.

  10. Royal Dutch to launch Russian activity; Moscow to open Sakhalin areas to bids

    SciTech Connect

    Not Available

    1992-10-05

    This paper reports that units of the Royal Dutch/Shell Group are poised to take a role in the Russian petroleum industry. Shell Development Sakhalin BV agreed to join the MMM group conducting a feasibility study for development of Piltun-Astokhskoye and Lunskoye oil and gas fields off Sakhalin Island. And Shell Rossiya AO was registered in Moscow to operate upstream and downstream. Meantime, Moscow's ITAR-TASS news agency last week reported Russia will take international bids for exploration and development onshore and off Sakhalin Island.

  11. [Why the Royal Dutch Medical Association does not blindly follow the euthanasia review committees].

    PubMed

    Hendriks, A C Aart

    2013-01-01

    The provisions of the Dutch Termination of Life on Request and Assisted Suicide Act are not always as clear as were originally hoped for. This also holds true with respect to the provision on the role of an advance directive in a case where the patient is no longer able to express his or her will. Euthanasia Review Committees now tend to interpret this provision broadly, although not always in a consistent way. The Royal Dutch Medical Association has its own responsibility in interpreting this provision in a way consistent with the professional standard.

  12. The use of colours on the the seventeenth century royal warship Vasa.

    PubMed

    Tångeberg, P

    2000-01-01

    The seventeenth-century Swedish Royal warship Vasa was painted and decorated with almost 500 figure sculptures and many carved ornaments. It is probably the most extensive sculptural work in wood to have been preserved from this period in European history. The ship's decorations are of particular importance given the scarcity of knowledge of how sculptures in general, and large ships in particular, were painted in Northern Europe during this period. About 20 different pigments have been characterized and it has been possible to reconstruct the appearance of many of the sculptures and to extend this knowledge to the ship's original appearance.

  13. The understanding of monsters at the Royal Society in the first half of the eighteenth century.

    PubMed

    da Costa, P F

    2000-01-01

    In tune with an Enlightenment sensibility that focused on the search for order and regularities, monsters were given a marginal position in eighteenth-century medical works. By contrast, they had an important place at the Royal Society during the second half of the century. This article first focuses on the general interest in monsters within the context of the natural historical agenda and corporate activity of the Society and then addresses the medical understanding of monsters by members of the Society. Finally, it discusses some of the moral and social implications of their medicalization in eighteenth century England.

  14. Energy R and D in the Netherlands

    SciTech Connect

    EEM Luiten; JJ Dooley; K Blok

    1999-09-07

    This report documents trends in R and D and in particular (public) energy R and D in the Netherlands. Besides quantitative information on R and D and energy R and D, the report gives an impression of changes in science and technology policy, energy policy and changes in energy research priorities (both organizational and financial). In the Netherlands, 2.09% of GDP (or $6.7 billion) was invested in R and D activities in 1995. The private sector financed 46% of all R and D in that year. A small but significant fraction (9.3%) of the research performed in the Netherlands is financed by foreign public and private sector entities. Energy R and D has been identified by the national Strategic Foresight Activity as an important area of R and D for government support in the future. This is due in part to the overall decline in public support for energy R and D that occurred from 1985 to 1995. However, recent concern over climate change and energy policy has resulted in increased budgets for energy R and D. Recent policy documents (e.g., the Memorandum on Energy R and D in April 1998) and initiatives (e.g., a recent university energy R and D program; intensification of climate policy, partly in R and D) indicate the growing interest in addressing the issue of climate change partly through energy R and D. The Dutch government believes that the liberalization of the energy market in the Netherlands justifies an active role for the government to guarantee the longer-term transformation to a sustainable energy system. In terms of climate policy, the expanded and more efficient use of natural gas is seen as a suitable transition option towards a sustainable energy system. However, energy efficiency (and in particular energy efficiency in the industrial sector) and the introduction of renewable technologies (solar energy, wind energy and biomass) are generally favored for the long term. Recently, additional funding was allocated for research on industrial ''breakthrough

  15. Innovation in the Netherlands: Toward Guidelines for Knowledge Transfer

    ERIC Educational Resources Information Center

    Stiekema, Esther I.

    2005-01-01

    When the objectives of the Lisbon Convention were formulated in 2000, the Dutch Government decided that the Netherlands should give priority to achieving these objectives. In 2010 the Netherlands should be one of the most successful economies in Europe, which should itself be the most competitive knowledge-based economic region in the world. With…

  16. The Future of Agricultural Education: The Case of the Netherlands

    ERIC Educational Resources Information Center

    Mulder, Martin; Kupper, Hendrik

    2006-01-01

    Agricultural education has been an essential factor in the success of agricultural development in the Netherlands. At present, as in many countries throughout the world, the position of agricultural education is threatened. Does agricultural education have a future in the Netherlands, and if so, what strategies are being used for its survive? This…

  17. Young Migrants and Discourses on Young Migrants in the Netherlands

    ERIC Educational Resources Information Center

    Gerritsen, Debby; Maier, Robert

    2012-01-01

    This article compares the perspectives of young migrants in the Netherlands with the dominant discourse on "migrants" at present. The integration of young "migrants" have been studied in the European research projects TRESEGY and PROFACITY with the help of a number of ethnographic studies and a questionnaire in the Netherlands.…

  18. The Salient History of Dalton Education in the Netherlands

    ERIC Educational Resources Information Center

    van der Ploeg, Piet

    2014-01-01

    In the Netherlands there are 400 Dalton schools, while Dalton education has all but disappeared elsewhere, including in its country of origin: the USA. Following a brief period in the 1920s in which it enjoyed strong international interest, it disappeared from the scene. How can it be that the Dalton Plan still exists only in the Netherlands? This…

  19. Innovation in the Netherlands: Toward Guidelines for Knowledge Transfer

    ERIC Educational Resources Information Center

    Stiekema, Esther I.

    2005-01-01

    When the objectives of the Lisbon Convention were formulated in 2000, the Dutch Government decided that the Netherlands should give priority to achieving these objectives. In 2010 the Netherlands should be one of the most successful economies in Europe, which should itself be the most competitive knowledge-based economic region in the world. With…

  20. Young Migrants and Discourses on Young Migrants in the Netherlands

    ERIC Educational Resources Information Center

    Gerritsen, Debby; Maier, Robert

    2012-01-01

    This article compares the perspectives of young migrants in the Netherlands with the dominant discourse on "migrants" at present. The integration of young "migrants" have been studied in the European research projects TRESEGY and PROFACITY with the help of a number of ethnographic studies and a questionnaire in the Netherlands.…

  1. The Future of Agricultural Education: The Case of the Netherlands

    ERIC Educational Resources Information Center

    Mulder, Martin; Kupper, Hendrik

    2006-01-01

    Agricultural education has been an essential factor in the success of agricultural development in the Netherlands. At present, as in many countries throughout the world, the position of agricultural education is threatened. Does agricultural education have a future in the Netherlands, and if so, what strategies are being used for its survive? This…

  2. Phytophthora ramorum experience and approach in the Netherlands

    Treesearch

    M.H.C.G. Steeghs; J. De Gruyter

    2006-01-01

    Phytophthora ramorum was found for the first time in the Netherlands in 1993. In 2001 a risk analysis was done. The results initiated a program to investigate the spread in the Netherlands and to develop measures to prevent further spread. The measures outside the nurseries gave rise to intensive discussions with the managers and owners of these...

  3. The Salient History of Dalton Education in the Netherlands

    ERIC Educational Resources Information Center

    van der Ploeg, Piet

    2014-01-01

    In the Netherlands there are 400 Dalton schools, while Dalton education has all but disappeared elsewhere, including in its country of origin: the USA. Following a brief period in the 1920s in which it enjoyed strong international interest, it disappeared from the scene. How can it be that the Dalton Plan still exists only in the Netherlands? This…

  4. XIXth century earthquakes in Belgium, the Netherlands and western Germany

    NASA Astrophysics Data System (ADS)

    Knuts, Elisabeth; Dost, Bernard; Alexandre, Pierre; Camelbeeck, Thierry

    2014-05-01

    Since the last quarter of the XXth century, the rules of the historic criticism are applied in the study of the past earthquakes thanks to the collaboration between seismologists and historians. Various monographs have already been published on the historic seismicity of Belgium, Netherlands and nearby regions but few about the XIXth century. The list of the shocks arisen in those regions is not clearly established. For the major earthquakes, we can find useful monographs that where published at the time of the events. However there is a lack of information about smaller earthquakes that are mentioned in the Belgian, Dutch, French and German catalogs. For those smaller events it is often not possible to determine the zone of perceptibility. Sometimes we cannot even take for sure that the reported event is a real one. The aim of our study is to overcome this gap. Taking into account the rules of historical criticism, we read all the available bibliography, undertook researches in the archives and made an analysis of the press in order to establish a reliable list of earthquakes. Several categories of sources were used: narrative and administrative sources, contemporaneous studies, letters sent to the scientific institutions and press. We could confirm that 84 earthquakes are real and determine a list of fake earthquakes that are unfortunately present in the traditional catalogs. In the list of fake earthquakes, we highlighted several events that we consider doubtful and that require additional researches, especially several earthquakes in mining zone. We compiled our results as a four-column table providing the date of the earthquake, the supposed epicenter, the number of founded sources and the number of macroseismic datapoints. Based on the macroseismic datapoints, we estimated the intensities for every great phenomenon according to EMS-98 scale. The map of the epicenters indicates that the most active zone in the area during the XIXth century is the Lower Rhine

  5. [Aquaculture in the Netherlands: problems and perspectives].

    PubMed

    Hogendoorn, H

    1986-11-15

    New interest is being focussed on the more than 100-year-old field of fish culture in the Netherlands. The systems of production available show varying degrees of control of the fish and their environment, and they have a corresponding yield: 0.01-250 kg/m3/year. The recently developed recirculation systems (40-80 kg/m3) make possible the commercial production of luxury species of fish, independently of climatological conditions and having minimum effects on the environment. Some technical aspects of reproduction, housing, nutrition, growth, health control and marketing of the fish require further attention. But the absence of a solid tradition of fish culture is the main problem in the development of fish culture in the Netherlands today. Good fish stockmanship is required at farmers' level. And the organisation and governmental support, that turned agriculture into a highly successful industry, are also essential. For the moment, the most promising commercial prospects are provided by a number of luxury fish species: trout, salmon, eel, sole, turbot, tilapia, catfish, seabass and seabream. A joint effort may help to overcome the remaining technical and logistical uncertainties.

  6. Prevalence of child maltreatment in The Netherlands.

    PubMed

    Euser, Eveline M; van Ijzendoorn, Marinus H; Prinzie, Peter; Bakermans-Kranenburg, Marian J

    2010-02-01

    The first nationwide prevalence study of child maltreatment in The Netherlands (NPM-2005) was designed as a replication of the National Incidence Studies (NISs) conducted in the United States. Child maltreatment cases were reported by 1,121 professionals from various occupational branches, trained in a detailed registration system of six types of abuse and neglect. In addition, cases registered by the Dutch Child Protection Services (CPS) were analyzed. For 2005, the overall prevalence rate was estimated to be 107,200 (95% CI 102,054-112,882) maltreated children aged 0-18 years, or 30 cases per 1,000 children. Neglect was the most prevalent type (56% of all cases) and sexual abuse had the lowest rate (4%). Of the maltreated children, 47% experienced more than one type of maltreatment. Major risk factors were very low parental education and unemployment. It is worrisome that CPS agencies only see the tip of the iceberg as only 12.6% of all maltreatment cases were reported to the CPS. Training of professionals in observing and reporting child maltreatment is badly needed. The absence of a legal obligation to report in The Netherlands needs reconsideration.

  7. [Postoperative pain control in The Netherlands].

    PubMed

    van den Nieuwenhuyzen, M C; Janss, R A; Brand, R; van Kleef, J W

    1994-04-30

    To determine how postoperative analgesia care is managed in the Netherlands. Descriptive study (questionnaire). Departments of anaesthesiology in all 168 Dutch hospitals. Questionnaires were sent inquiring about postoperative pain therapies and their complications, the organisation and management of postoperative analgesic care, the importance of effective pain control, factors of influence on patient's assessment of pain and the management of the quality of postoperative analgesia. The questionnaires of 73% (n = 122) of the hospitals were suitable for analysis. Locoregional analgesic techniques are used, but intermittent intramuscular administration of an opioid is still the analgesic therapy of choice in the postoperative period. 89% of the interviewed anaesthesiologists assess the average intensity of postoperative pain as moderate or severe, and more than half of the interviewed anaesthesiologists answered that effective postoperative pain management is of substantial influence on the postoperative recovery of the patient. It is essential to improve postoperative pain control in the Netherlands. Frequent assessments and precise documentation of the intensity of pain and pain relief, on which further therapy can be based, might be a first step in improving postoperative pain control. Optimal postoperative pain management requires the input of equipment and staff.

  8. Cervical Ripening in The Netherlands: A Survey

    PubMed Central

    Huisman, Claartje M. A.; Jozwiak, Marta; de Leeuw, Jan Willem; Mol, Ben Willem; Bloemenkamp, Kitty W. M.

    2013-01-01

    Objective. We aim to investigate methods and use of cervical ripening in women without and with a prior cesarean delivery in The Netherlands. Methods. In 2010, we conducted a postal survey in all Dutch hospitals with a labor ward. One gynecologist per hospital was addressed and was asked to respond on behalf of the staff. The questionnaire contained 31 questions concerning cervical ripening and induction of labor. We compared this survey to a similar Dutch survey conducted in 2006. Results. Response rate was 78% (70/92 hospitals). In women without a prior cesarean and in need of cervical ripening, all hospitals (100%) applied prostaglandins (either E1 or E2). In women with a prior cesarean, 21.4% of the hospitals performed an elective cesarean section if delivery was indicated (26.0% in 2006). In case of cervical ripening, 72.7% used mechanical methods (49.1% in 2006), 20.0% used prostaglandins (40.4% in 2006), 3.6% used a combination of prostaglandins and mechanical methods, and 3.6% used membrane-sweeping or oxytocin. Conclusions. In 2010, in The Netherlands, prostaglandins and Foley catheters were the preferred methods for cervical ripening in women without and with a prior cesarean, respectively. Use of mechanical methods in women with a prior cesarean has increased rapidly between 2006 and 2010, corresponding with decreasing use of prostaglandins and elective repeat cesarean sections. PMID:23997770

  9. Urban Scaling of Cities in the Netherlands.

    PubMed

    van Raan, Anthony F J; van der Meulen, Gerwin; Goedhart, Willem

    2016-01-01

    We investigated the socioeconomic scaling behavior of all cities with more than 50,000 inhabitants in the Netherlands and found significant superlinear scaling of the gross urban product with population size. Of these cities, 22 major cities have urban agglomerations and urban areas defined by the Netherlands Central Bureau of Statistics. For these major cities we investigated the superlinear scaling for three separate modalities: the cities defined as municipalities, their urban agglomerations and their urban areas. We find superlinearity with power-law exponents of around 1.15. But remarkably, both types of agglomerations underperform if we compare for the same size of population an agglomeration with a city as a municipality. In other words, an urban system as one formal municipality performs better as compared to an urban agglomeration with the same population size. This effect is larger for the second type of agglomerations, the urban areas. We think this finding has important implications for urban policy, in particular municipal reorganizations. A residual analysis suggests that cities with a municipal reorganization recently and in the past decades have a higher probability to perform better than cities without municipal restructuring.

  10. Urban Scaling of Cities in the Netherlands

    PubMed Central

    van Raan, Anthony F. J.; van der Meulen, Gerwin; Goedhart, Willem

    2016-01-01

    We investigated the socioeconomic scaling behavior of all cities with more than 50,000 inhabitants in the Netherlands and found significant superlinear scaling of the gross urban product with population size. Of these cities, 22 major cities have urban agglomerations and urban areas defined by the Netherlands Central Bureau of Statistics. For these major cities we investigated the superlinear scaling for three separate modalities: the cities defined as municipalities, their urban agglomerations and their urban areas. We find superlinearity with power-law exponents of around 1.15. But remarkably, both types of agglomerations underperform if we compare for the same size of population an agglomeration with a city as a municipality. In other words, an urban system as one formal municipality performs better as compared to an urban agglomeration with the same population size. This effect is larger for the second type of agglomerations, the urban areas. We think this finding has important implications for urban policy, in particular municipal reorganizations. A residual analysis suggests that cities with a municipal reorganization recently and in the past decades have a higher probability to perform better than cities without municipal restructuring. PMID:26751785

  11. Supplementation with Major Royal-Jelly Proteins Increases Lifespan, Feeding, and Fecundity in Drosophila.

    PubMed

    Xin, Xiao-Xuan; Chen, Yong; Chen, Di; Xiao, Fa; Parnell, Laurence D; Zhao, Jing; Liu, Liang; Ordovas, Jose M; Lai, Chao-Qiang; Shen, Li-Rong

    2016-07-27

    The major royal-jelly proteins (MRJPs) are the main constituents responsible for the specific physiological role of royal jelly (RJ) in honeybees. Male and female Drosophila flies were fed diets containing either no MRJPs (A) or casein (B) at 1.25% (w/w) of diet or MRJPs at 1.25% (C), 2.50% (D), or 5.00% (E). Diets B, C, D, and E increased mean lifespan by 4.3%, 9.0%, 12.4%, and 13.9% in males and by 5.8%, 9.7%, 20.0%, and 11.8% in females in comparison to results from diet A, respectively. The diet supplemented with 2.50% MRJPs seems to have the optimal dose to improve both physiological and biochemical measures related to aging in both sexes. Interestingly, lifespan extension by MRJPs in Drosophila was positively associated with feeding and fecundity and up-regulation of copper and zinc-superoxide dismutase (CuZn-SOD) and the Egfr-mediated signaling pathway. This study provides strong evidence that MRJPs are important components of RJ for prolonging lifespan in Drosophila.

  12. Novel royal jelly proteins identified by gel-based and gel-free proteomics.

    PubMed

    Han, Bin; Li, Chenxi; Zhang, Lan; Fang, Yu; Feng, Mao; Li, Jianke

    2011-09-28

    Royal jelly (RJ) plays an important role in caste determination of the honeybee; the genetically same female egg develops into either a queen or worker bee depending on the time and amount of RJ fed to the larvae. RJ also has numerous health-promoting properties for humans. Gel-based and gel-free proteomics approaches and high-performance liquid chromatography-chip quadruple time-of-flight tandem mass spectrometry were applied to comprehensively investigate the protein components of RJ. Overall, 37 and 22 nonredundant proteins were identified by one-dimensional gel electrophoresis and gel-free analysis, respectively, and 19 new proteins were found by these two proteomics approaches. Major royal jelly proteins (MRJPs) were identified as the principal protein components of RJ, and proteins related to carbohydrate metabolism such as glucose oxidase, α-glucosidase precursor, and glucose dehydrogenase were also successfully identified. Importantly, the 19 newly identified proteins were mainly classified into three functional categories: oxidation-reduction (ergic53 CG6822-PA isoform A isoform 1, Sec61 CG9539-PA, and ADP/ATP translocase), protein binding (regucalcin and translationally controlled tumor protein CG4800-PA isoform 1), and lipid transport (apolipophorin-III-like protein). These new findings not only significantly increase the RJ proteome coverage but also help to provide new knowledge of RJ for honeybee biology and potential use for human health promotion.

  13. Observing the skies of Lisbon. Isaac de Sequeira Samuda, an estrangeirado in the Royal Society

    PubMed Central

    Vieira, Carla Costa

    2014-01-01

    Elected in 1723, Isaac de Sequeira Samuda (1681–1729) was the first Jewish Fellow of the Royal Society. He had arrived in London just a few years earlier, escaping from the Portuguese Inquisition. Despite his past, he had no difficulty in establishing links with his country's diplomatic representatives in London. A physician and adviser on scientific subjects, he became a conduit between the emerging world of Portuguese astronomy and the British scientific community. He reported to the Royal Society on astronomical observations made in the new observatories in Lisbon and helped with the acquisition of scientific instruments and books destined for Portugal. These activities were facets of Samuda's unusual career and the diverse though often converging associations that he established until his death. As the member of a network active in the diffusion of new ideas and in the modernization of Portuguese science, Samuda can be regarded as an estrangeirado, as this term has come to be used in the modern literature. PMID:24921106

  14. Fruit quality of Redhaven and Royal Glory peach cultivars on seven different rootstocks.

    PubMed

    Orazem, Primoz; Stampar, Franci; Hudina, Metka

    2011-09-14

    Two peach cultivars, Redhaven and Royal Glory, grafted on seven different rootstocks (Adesoto, Barrier 1, GF 677, Ishtara, Monegro, Penta, and peach seedling) were analyzed for tree vigor and yield. Fruit of similar ripeness (fruit firmness) was analyzed in terms of pomological (fruit weight, soluble solids content) and biochemical parameters (individual sugars, organic acids, phenolic acids in the flesh and peel, as well as flavonols and anthocyanins in the peel). A uniform effect of rootstock on tree size was evident in the cases of both cultivars. The Ishtara rootstock induced weak tree growth; Adesoto, Penta and peach seedling semivigorous growth; and Barrier 1, GF 677, and Monegro vigorous tree growth. We recorded higher yields in the Redhaven cultivar, while no significant differences in yield in the fourth growing season were found among the rootstocks for each cultivar. Rootstock had no effect on soluble solids in the Redhaven cultivar, while in the Royal Glory it did. Penta yielded the highest soluble solids content levels, while Adesoto and Monegro were associated with low levels. In the fruit from both cultivars, the rootstock had a significant influence on individual sugars, organic acids, and phenolic acids in the pulp. We also found that phenolic acids in the pulp and skin were more affected by the rootstock than other secondary metabolites analyzed, regardless of the cultivar.

  15. Abnormal chemical element concentrations in lichens of Isle Royale National Park

    USGS Publications Warehouse

    Bennett, J.P.

    1995-01-01

    Lichens have been used for many years to monitor changes in deposited airborne chemical elements in many areas, but few studies have focused on areas suspected of experiencing slightly elevated pollution. Detection of subtle patterns of slightly elevated pollutants calls for developing several lines of evidence as opposed to single line studies used in heavily polluted areas. This study of two lichen species, Hypogymnia physodes and Evernia mesomorpha, in Isle Royale National Park, Michigan compares the concentrations and ranks of elements with the concentrations and ranks of the elements in the earth's crust, changes in element concentrations over a nine year period, and the geography of element concentrations in the park. S, Zn, Pb, Cd and Se were elevated in both species and higher in rank compared to the concentrations and ranks in the earth's crust. Toxic elements increased 123% in Hypogymnia and 62% in Evernia over 9 years, compared to increases of 45% and 59% for non-toxic elements in each species, respectively. Geographically, the lichens at certain localities with higher exposures experienced higher than average element concentrations. Finally, tissue concentrations of Mn, S and Se at some localities were above levels known to be either toxic or similar to those found in polluted areas. These four lines of evidence suggest that Isle Royale National Park is experiencing the onset of chronic air pollution stress from a number of sources.

  16. Effect of Major Royal Jelly Proteins on Spatial Memory in Aged Rats: Metabolomics Analysis in Urine.

    PubMed

    Chen, Di; Liu, Fang; Wan, Jian-Bo; Lai, Chao-Qiang; Shen, Li-Rong

    2017-04-10

    Royal jelly (RJ) produced by worker honeybees is the sole food for the queen bee throughout her life as well as the larvae of worker bees for the first 3 days after hatching. Supplementation of RJ in the diet has been shown to increase spatial memory in rodents. However, the key constituents in RJ responsible for improvement of cognitive function are unknown. Our objective was to determine if the major royal jelly proteins (MRJPs) extracted from RJ can improve the spatial memory of aged rats. The spatial memory assay using the Morris water maze test was administered once to rats after a 14-week feeding. Metabolomics analysis based on quadrupole time-of-flight mass spectrometry was conducted to examine the differences in compounds from urine. Aged male rats fed MRJPs showed improved spatial memory up to 48.5% when compared to the control male aged rats fed distilled water. The metabolite pattern of the MRJPs-fed aged rats was regressed to that of the young rats. Compounds altered by MRJPs were mapped to nicotinate and nicotinamide metabolism, cysteine taurine metabolism, and energy metabolism pathways. In summary, MRJPs may improve spatial memory and possess the potential for prevention of cognitive impairment via the cysteine and taurine metabolism and energy metabolism pathways in aged rats.

  17. Keynes, Newton and the Royal Society: the events of 1942 and 1943

    PubMed Central

    Kuehn, Daniel

    2013-01-01

    Most discussions of John Maynard Keynes's activities in connection with Newton are restricted to the sale in 1936 at Sotheby's of Newton's Portsmouth Papers and to Keynes's 1946 essay ‘Newton, the Man’. This paper provides a history of Keynes's Newton-related work in the interim, highlighting especially the events of 1942 and 1943, which were particularly relevant to the Royal Society's role in the domestic and international promotion of Newton's legacy. During this period, Keynes lectured twice on Newton, leaving notes that would later be read by his brother Geoffrey in the famous commemoration of the Newton tercentenary in 1946. In 1943 Keynes assisted the Royal Society in its recognition of the Soviet celebrations and in the acquisition and preservation of more of the Newton library. In each instance Keynes took the opportunity to promote his interpretation of Newton as ‘the last of the magicians’: a scientist who had one foot in the pre-modern world and whose approach to understanding the world was as much intuitive as it was methodical. PMID:24686919

  18. Proteomic analysis of royal jelly from three strains of western honeybees (Apis mellifera).

    PubMed

    Li, Jianke; Wang, Ting; Zhang, Zhaohui; Pan, Yinghong

    2007-10-17

    To compare the protein complement of royal jelly (RJ) from high RJ producing honeybees ( Apis mellifera L.), a strain of A. mellifera artificially selected for increased RJ production from Italian honeybees in China for more than two decades was compared to those of native Italian honeybees ( A. mellifera L.) and Carnica honeybees ( A. mellifera C.); the protein in RJ from these three strains of honeybees was partially identified by using a combination of two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS), and a protein engine identification tool applied to the honeybee genome. The results showed that 152, 157, and 137 proteins were detected in the three species of RJ; among which 57, 57, 51 high abundant proteins ere identified, respectively. Most identifited spots, 45, 45, 41, were assigned to major royal jelly proteins (MRJPs). Remarkable differences were found in the heterogeneity of the MRJPs, in particular, MRJP3. Also, 3-glucose oxidase, 1-peroxiredoxin (PRDX), and 1-glutathione S-transferase (GST) S1 were identified in three RJ samples. Furthermore, during the determination of the peptides mass fingerprinting (PMF) of each spot, for the first time, PRDX and GST S1 proteins have been identified in RJ. Thus, the results suggest that the protein complement of high RJ producing honeybees is not different compared to native Italian honeybees, while a difference remains between Carnica honeybees.

  19. A history of the gardens of the Royal College of Physicians of London.

    PubMed

    Hollman, Arthur

    2009-06-01

    The Royal College of Physicians of London (RCP) was founded in the City of London in 1518 and at that time many of the royal, religious and lay residences had gardens. The gardens were used, among other things, to grow fruit trees, herbs for the kitchen and for strewing on the floor, and for leisure, with lawns, bowling and flowers. So it would have been natural for the RCP Fellows to wish to have a garden of their own. This was not possible until the College moved into its second and third homes in the City in 1614 and 1674 and good street plans of these sites, and of their gardens, have now become available, though we lack any details of the planting. The fourth home in Pall Mall East in 1815 was landlocked. Therefore when the fifth (and current) home in Regent's Park was opened in 1964 it was splendid to have a large garden, carefully designed, planted and recorded. In 2004 a wonderful transformation took place when the College created a modern physic garden showing the development of medicinal plants through the ages and in many parts of the world.

  20. Keynes, Newton and the Royal Society: the events of 1942 and 1943.

    PubMed

    Kuehn, Daniel

    2013-03-20

    Most discussions of John Maynard Keynes's activities in connection with Newton are restricted to the sale in 1936 at Sotheby's of Newton's Portsmouth Papers and to Keynes's 1946 essay 'Newton, the Man'. This paper provides a history of Keynes's Newton-related work in the interim, highlighting especially the events of 1942 and 1943, which were particularly relevant to the Royal Society's role in the domestic and international promotion of Newton's legacy. During this period, Keynes lectured twice on Newton, leaving notes that would later be read by his brother Geoffrey in the famous commemoration of the Newton tercentenary in 1946. In 1943 Keynes assisted the Royal Society in its recognition of the Soviet celebrations and in the acquisition and preservation of more of the Newton library. In each instance Keynes took the opportunity to promote his interpretation of Newton as 'the last of the magicians': a scientist who had one foot in the pre-modern world and whose approach to understanding the world was as much intuitive as it was methodical.

  1. The 'royal disease'--haemophilia A or B? A haematological mystery is finally solved.

    PubMed

    Lannoy, N; Hermans, C

    2010-11-01

      'History can change blood. And blood can change the course of history'. Haemophilia is an illustration of this, as this congenital hereditary coagulation disorder, passed through the majority of royal European families at the beginning of the 20th century by Queen Victoria of England and Empress of the Indies, had indisputable political consequences, which led to one of the most defining moments of contemporary history: the Bolshevik Revolution. Today, none of Queen Victoria's living descendents carry haemophilia. Because of this, the characterization of haemophilia (deficit of either factor VIII or XI) and the identification of the causal mutation are rendered impossible. In 1991, a tomb containing the remains of Czar Nicolas II's entire family was discovered. A second tomb was discovered in 2007, allowing Russian and American scientists to fill in this gap in medical history. Following a scientific approach combining current genetic experimentation tools and the development of biological information technology, researchers were able to identify each body, allowing them to obtain precious genetic material from the young Czar Alexis, who was stricken by the disease, which revealed a causal substitution in the splice acceptor site of exon 4 in the F9 gene. This mutation that is responsible for haemophilia B had traumatized European royal families throughout the 20th century!

  2. Royal College of Nursing (Rcn) code of professional conduct: a discussion document.

    PubMed Central

    Dawson, J D; Altschul, A T; Sampson, C; Smith, A M

    1977-01-01

    We are printing in its entirety the discussion document which sets out a code of professional conduct for nurses published by the Royal College of Nursing in November 1976 together with commentaries by the Assistant Secretary of the British Medical Association, a professor of nursing studies, student nurses and a lawyer. The image of the nurse is still that of one of Florence Nightingale's young ladies or of a member of a religious order who is wholly dedicated to caring for the sick. Today, as this document and the comments upon it show, 'dedication' is still part of the motive which leads a man or woman to become a nurse but in addition, and this is where the public may be ignorant or choose to be ignorant, nursing offers a career where intellectual achievement and the satisfaction of a demanding job bring their proper financial reward and place in the professional community. We are grateful to the Royal College of Nursing for permission to publish this document. PMID:926130

  3. [Tuberculosis in the Royal Norwegian Navy at the time of the Second World War].

    PubMed

    Ongre, Aksel; Sommerfelt-Pettersen, Jan

    2008-12-18

    Tuberculosis became a great problem in the Royal Norwegian Navy during the first years of the Second World War (when it operated in allied services mainly from the UK); with the highest incidence (9.6 per 1 000) during the first half of 1943. Main reasons were insufficient medical examination of recruits, crowded living conditions on board (favoured the contagion) and the physical and psychological pressure during sea operations, which may have reduced the immune defence. Prophylactic measures in terms of tuberculin testing of all personnel, chest X-rays of the positives, vaccination of the negatives, environment investigation when disease was discovered, and isolation of those infected, gave control from the second half of 1943 and onwards. The article also mentions treatment, repatriation and the incidence of tuberculosis in the Norwegian Navy before and after the war as well as in the Royal Canadian Naval Services (where the incidence was low) during the war. Today, the tuberculosis situation in Norway is so favourable that routine chest X-ray of the recruits is no longer performed in the armed forces.

  4. Purification, crystallization and preliminary X-ray diffraction analysis of royal palm tree (Roystonea regia) peroxidase

    SciTech Connect

    Watanabe, Leandra; Nascimento, Alessandro S.; Zamorano, Laura S.; Shnyrov, Valery L.; Polikarpov, Igor

    2007-09-01

    The purification, crystallization, X-ray diffraction data acquisition and molecular-replacement results of royal palm tree (R. regia) peroxidase are described. Royal palm tree peroxidase (RPTP), which was isolated from Roystonea regia leaves, has an unusually high stability that makes it a promising candidate for diverse applications in industry and analytical chemistry [Caramyshev et al. (2005 ▶), Biomacromolecules, 6, 1360–1366]. Here, the purification and crystallization of this plant peroxidase and its X-ray diffraction data collection are described. RPTP crystals were obtained by the hanging-drop vapour-diffusion method and diffraction data were collected to a resolution of 2.8 Å. The crystals belong to the trigonal space group P3{sub 1}21, with unit-cell parameters a = b = 116.83, c = 92.24 Å, and contain one protein molecule per asymmetric unit. The V{sub M} value and solvent content are 4.07 Å{sup 3} Da{sup −1} and 69.8%, respectively.

  5. Molecular genetic analysis on the remains of the Dark Countess: Revisiting the French Royal family.

    PubMed

    Parson, Walther; Berger, Cordula; Sänger, Timo; Lutz-Bonengel, Sabine

    2015-11-01

    The "Dark Counts" were a mysterious couple that appeared in the Thuringian village Eishausen in 1807. After living in self imposed solitude for 30 years the woman died and was buried under the name Sophia Botta. Her companion, who presented himself as Vavel de Versay, died in 1845 and was later identified as Leonardus Cornelius van der Valck, secretary of the Dutch embassy in Paris. Their lifestyle led to speculations that she was the true princess Marie Thérèse Charlotte of France, daughter of Louis XVI and Marie Antoinette. According to these speculations she was substituted by another young woman on a voyage from Paris to Vienna. Molecular genetic analyses were set out to test the remains attributed to the Dark Countess. Mitochondrial DNA testing brought concordant results determined in two forensic laboratories (Innsbruck, Austria and Freiburg, Germany) on parallel samples of the remains. The results were in exclusion to both, the mitochondrial lineage earlier reported for the French Royal family and the mitochondrial haplotype observed in a living descendant of the Royal family.

  6. Quantitative Analysis of Apisin, a Major Protein Unique to Royal Jelly

    PubMed Central

    Arai, Yasuko; Kato, Kenji

    2016-01-01

    Apisin, a protein that is unique to royal jelly (RJ), is known to compose the greater part of the RJ proteins and to exist as a heterooligomer containing major royal jelly protein 1 and apisimin. However, few reports on the methods for quantifying apisin have been published. Thus, we attempted to quantify apisin using HPLC, a widely used analytical technique, as described below. Isoelectric precipitation and size-exclusion chromatography were used to obtain the purified protein, which was identified as apisin by SDS-PAGE and LC-MS analyses. The purified apisin was lyophilized and then used to generate a calibration curve to quantify apisin in RJ. The apisin content was fairly constant (i.e., 3.93 to 4.67 w/w%) in natural RJ. This study is the first to describe a simple, standardized method for quantifying apisin using HPLC and suggests that apisin can be used as a benchmark for future evaluations of RJ quality. PMID:27721892

  7. Access to health care for undocumented migrants: a comparative policy analysis of England and the Netherlands.

    PubMed

    Grit, Kor; den Otter, Joost J; Spreij, Anneke

    2012-02-01

    The presence of undocumented migrants is increasing in many Western countries despite wide-ranging attempts by governments to increase border security. Measures taken to control the influx of immigrants include policies that restrict access to publicly funded health care for undocumented migrants. These restrictions to health care access are controversial, and evidence suggests they do not always have the intended effect. This study provides a comparative analysis of institutional, actor-related, and contextual factors that have influenced health care policy development on undocumented migrants in England and the Netherlands. For undocumented migrants, England restricts its access to care at the point of service, while the Netherlands restricts through the payment system for services. The study includes an analysis of policy papers and semistructured, in-depth interviews with various actors in both countries. Findings confirm the influence of such contextual factors as immigration considerations and cost concerns on health care policy making in this area. However, these factors cannot explain the differences between the two countries. Previously enacted policies, especially the organization of the health care system, affected the kind of restrictions for undocumented migrants. Concerns about the side effects of generous treatment of undocumented migrants on other groups played a substantial role in formulating restrictive policies in both countries. Evidently, policy development and implementation is critically affected by institutional rules, which govern the degree of influence that doctors and professional medical associations have on the policy process.

  8. Religion and Fertility in Western Europe: Trends Across Cohorts in Britain, France and the Netherlands.

    PubMed

    Peri-Rotem, Nitzan

    The role of religion in explaining fertility differences is often overlooked in demographic studies, particularly in Western Europe, where there has been a substantial decline in institutional forms of religious adherence. The current study explores the changing relationships between religion and childbearing in Britain, France and the Netherlands. Using data from the Generations and Gender Programme and the British Household Panel Survey, religious differences in completed fertility and the transition to first birth are explored across cohorts of women. In addition, a longitudinal analysis is employed to examine the influence of religion on subsequent childbearing. Although the secularization paradigm assumes that the influence of religion on individual behavior will diminish over time, it is found that religious affiliation and practice continue to be important determinants of fertility and family formation patterns. However, there is some variation in the relationship between religion and fertility across countries; while in France and the Netherlands fertility gaps by religiosity are either consistent or increasing, in Britain, this gap appears to have narrowed over time. These findings suggest that fertility differences by religion also depend on the particular social context of religious institutions in each country.

  9. South[ern] Africa's "Dar ul-'Ulums": Institutions of Social Change for the Common Good?

    ERIC Educational Resources Information Center

    Haron, Muhammed

    2014-01-01

    Muslim communities in principally non-Muslim nation states (e.g. South Africa, United States of America, the United Kingdom and the Netherlands) established a plethora of Muslim theological institutions. They have done so with the purpose of educating and reinforcing their Muslim identity. These educational structures have given rise to numerous…

  10. The Royal Society, natural history and the peoples of the 'New World(s)', 1660-1800.

    PubMed

    Gascoigne, John

    2009-12-01

    This paper focuses on the response of the Royal Society to the increasing contact with parts of the globe beyond Europe. Such contact was in accord with the programme of Baconian natural history that the early Royal Society espoused, but it also raised basic questions about the extent and nature of the pursuit of natural history. In particular, the paper is concerned with the attention paid to one particular branch of natural history, the study of other peoples and their customs. Such scrutiny of other peoples in distant lands raised basic questions about what methods natural history should employ and the extent to which it could serve as a foundation for more general and theoretical claims. By taking a wide sweep from the beginnings of the Royal Society until the end of the eighteenth century it is hoped light will be shed on the changing understanding of natural history over this period.

  11. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses.

    PubMed

    Sugiyama, Tsuyoshi; Takahashi, Keita; Mori, Hiroshi

    2012-12-01

    Royal jelly is a food for queen and larvae honeybees. 10-Hydroxy-trans-2-decenoic acid (10H2DA; "royal jelly acid") is the principal lipid component in royal jelly. Several pharmacological activities of 10H2DA have been reported: anti-tumor, anti-biotic, immunomodulatory, estrogenic and neurogenic. We recently revealed an inhibitory effect of 10H2DA in innate immune signals. Despite appreciable advances in studies on innate immune signals after the identification of Toll-like receptors as innate immune receptors, few studies have reported the effect of 10H2DA on innate immune signals. In this review, we focus on recent advances in the evaluation of the biological activities of 10H2DA (especially immunomodulatory activities). We also discuss the molecular mechanisms underpinning these biological activities, which could lead to new therapeutic targets for the treatment of immune disorders.

  12. Food to some, poison to others - honeybee royal jelly and its growth inhibiting effect on European Foulbrood bacteria.

    PubMed

    Vezeteu, Thomas V; Bobiş, Otilia; Moritz, Robin F A; Buttstedt, Anja

    2017-02-01

    Honeybee colonies (Apis mellifera) serve as attractive hosts for a variety of pathogens providing optimal temperatures, humidity, and an abundance of food. Thus, honeybees have to deal with pathogens throughout their lives and, even as larvae they are affected by severe brood diseases like the European Foulbrood caused by Melissococcus plutonius. Accordingly, it is highly adaptive that larval food jelly contains antibiotic compounds. However, although food jelly is primarily consumed by bee larvae, studies investigating the antibiotic effects of this jelly have largely concentrated on bacterial human diseases. In this study, we show that royal jelly fed to queen larvae and added to the jelly of drone and worker larvae, inhibits not only the growth of European Foulbrood-associated bacteria but also its causative agent M. plutonius. This effect is shown to be caused by the main protein (major royal jelly protein 1) of royal jelly.

  13. Determination and confirmation of methyl p-hydroxybenzoate in royal jelly and other foods produced by the honey bee.

    PubMed

    Ishiwata, H; Takeda, Y; Yamada, T; Watanabe, Y; Hosagai, T; Ito, S; Sakurai, H; Aoki, G; Ushiama, N

    1995-01-01

    Methyl p-hydroxybenzoate (methyl paraben) in foods produced by the Honey Bee was determined by HPLC and confirmed by GC-MS. The compound was detected at a mean concentration of 22.3 +/- 6.8 mg/kg (between 14.2 and 31.9 mg/kg) in commercial royal jelly, but was not detected in honey, propolis or pollen lumps at the detection limit of 1 mg/kg. Fresh royal jelly collected from apiaries contained methyl p-hydroxybenzoate at a concentration of 20.3 +/- 4.7 mg/kg (between 12.5 and 31.7 mg/kg). These results indicate that the methyl p-hydroxybenzoate in royal jelly is not added but is a natural component.

  14. [Influence of honey, royal jelly and propolis on accelerating acetate healing of experimental gastric ulcers in rats].

    PubMed

    Belostotskiĭ, N I; Kas'ianenko, V I; Dubtsova, E A; Lazebnik, L B

    2009-01-01

    This study examines gastric acetic ulcer healing in the rat after administration of honey, royal jelly and propolis into the stomach. Chronic gastric ulcers were induced in male Wistar rats by the application of 100% acetic acid to the serosal surface of the stomach on 60 sec. Bee-keeping products were administrated into the stomach from 2nd to 7th day after acetic ulcer induction. On 7th day animals were killed, and ulcer area was measured in mm2. In gastric juice pH and activity of pepsin were measured. The healing of acetic ulcers is accelerated with the administration of honey, royal jelly or propolis during six days. The largest healing effect was demonstrated with propolis and royal jelly, smaller one with the honey. It was revealed decrease of stomach acid secretion in the rats, which have received bee-keeping products versus the rats of control group.

  15. NEWS: Institute news

    NASA Astrophysics Data System (ADS)

    2000-07-01

    When Mary took up her appointment in the Institute's Education Department in June 1997, she indicated that she wished to return to teaching in two or three years. We have just heard that in September she will be joining the staff of the Science Department at Camden Girls' School, London. Mary's departure from the Institute is a great loss to the Department, where she has worked tirelessly, and with great imagination, to support those who teach physics at all secondary levels - and at primary level too when the opportunity presented itself. She has made tremendous contributions to the careers side of the Department's work, supporting careers events, providing informal training for others willing to do the same, helping to develop new careers materials and identifying people whom the Institute could use as role models or as the subject of case studies in print or electronic publications. Mary has been equally happy and willing to support pupils, students and teachers, and has been a wonderful role model herself, coming from an industrial research background, training for teaching after a career break and willing and able to teach biology, chemistry and design technology as well as physics. Mary has also written and edited Phases virtually single-handed. We are delighted to hear that Mary will continue to support the department's work as one of its teacher `volunteers'. Ilya Eigenbrot We are pleased to report that Ilya Eigenbrot, who will be known to some through his work at the Royal Institution and his appearances at the Christmas Lectures in a technical support role, has agreed to give the IOP Schools (touring) Lecture next year. The subject will be Lasers and this will follow nicely on to Zbig's lecture this year. Resources (print) Physics on Course The tenth issue of the Institute's popular guide to higher education, Physics on Course 2001, will be published early in July and distributed to all schools and colleges in the United Kingdom and the Republic of

  16. Microsatellite analysis of royal jelly producing traits of Italian honeybee (Apis mellifera Liguatica).

    PubMed

    Chen, Sheng-Lu; Li, Jian-Ke; Zhong, Bo-Xiong; Su, Song-Kun

    2005-10-01

    Genetic variations at 10 microsatellite loci were surveyed to determine the evolutionary relationships and molecular characteristics of three different honeybee (Apis mellifera L.) populations from Italy and China, i. e., native Italian (Ee), Chinese-Italian (Eb) and selected high royal jelly producing bees (Ea). A total of 96 alleles,an average of 9.6 alleles per locus,were scored in Ee,Eb and Ea bees at 10 loci. Out of which 48 (5%) were different. This indicated a high degree of polymorphism and ever, some genetic differentiation among the three populations due to artificial selection and geographical isolation. The polymorphic information contents (PIC) and heterozyosity of the three populations at 10 loci were 0.57, 0.50, 0.57, and 0.60, 0.57, 0.61, for Ee, Eb, Ea populations respectively, neither of which were different. This indicated same gene diversity within the three populations. The genetic distance was shorter between Ee and Eb bees as well as between Eb and Ea bees. Whereas that between Ee and Eb bees was longer. Further analysis indicated that the allele frequency of seven alleles at six loci (159 bp at A29,100 bp and 104 bp at A24; 110 bp at A7; 126 bp at A43, 221 bp at A14 and 221 bp at A113) increased going from Ee to Eb to Ea bees. Paired tests showed significant higher allele frequency between Ea and Eb bees,as well as between Ea and Eb bees. This indicates that these seven alleles are likely molecular markers of the high royal jelly producing bees. In addition,the allele frequency of four alleles at four loci (106 bp at A24,140 bp at A43;215 bp at A113 and 219 bp at A14) decreased going from Ea bees to Eb to Ee. Paired tests indicated significant lower allele frequency between Ea and Ee bees,as well as between Ea and Eb bees. Those four alleles may be the genetic markers for low royal jelly production.

  17. [Determination of four insecticide residues in honey and royal jelly by gas chromatography-negative chemical ionization mass spectrometry].

    PubMed

    Xia, Guanghui; Shen, Weijian; Yu, Keyao; Wu, Bin; Zhang, Rui; Shen, Chongyu; Zhao, Zengyun; Bian, Xiaohong; Xu, Jiyang

    2014-07-01

    A method was developed for the determination of four insecticide residues in honey and royal jelly by gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS). The honey and royal jelly samples were treated with different preparation methods as the result of the different components. The honey sample was extracted with ethyl acetate and cleaned up with primary second amine, and the royal jelly sample was extracted with acetonitrile-water (1:1, v/v), and cleaned up with a C18 solid-phase extraction column. Finally, the extracts of the honey and royal jelly were analyzed by GC-NCI/MS in selected ion monitoring (SIM) mode separately. External standard calibration method was used for quantification. The linearities of calibration curves of the four insecticides were good with the correlation coefficients greater than 0.99 in the range of 50-500 microg/L. The limits of the detection (LODs) of the four insecticides were in the range of 0.12- 5.0 microg/kg, and the limits of the quantification (LOQs) were in the range of 0.40-16.5 microg/kg. The recoveries of the four insecticides spiked in honey and royal jelly at three spiked levels (10, 15 and 20 microg/kg) were in the range of 78.2 -110.0%, and the relative standard deviations (RSDs) were all below 14%. The sensitivity and selectivity of this method were good with no interfering peaks. The proposed method is simple quick and effective to analyze the four insecticide residues in honey and royal jelly.

  18. Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-‎induced male rats

    PubMed Central

    Amirshahi, Tayebeh; Najafi, Gholamreza; Nejati, Vahid

    2014-01-01

    Background: Bleomycin (BL) is a glycopeptide antibiotic obtained from the bacterium Streptomyces verticillus which is routinely used for treatment of human cancers. Royal jelly (RJ) is a production from the hypo pharyngeal, mandibular and post cerebral glands of nurse bees. RJ consists of 66% water, 15% sugars, 5% lipids, and 13% proteins, essential amino acids and vitamins. Objective: The aim of present study was to evaluate protective effect of royal jelly on sperm parameters and malondialdehyde (MDA) production in rat. Materials and Methods: Forty adult male wistar rats (220±20gr) were randomly divided into 4 groups (n=10). Control group (CG) received normal saline 10 ml/kg twice a week with Intraperitoneal (I.P) for 48 days (0.3 ml/rat(. Royal Jelly group (RJG) received jelly (100 mg/kg daily) for 48 days orally. Bleomycin group (BLG) received BL (10 mg/kg twice a week) with I.P for 48 days. Royal Jelly+ Bleomycin group (RJ+BLG) received royal Jelly (100 mg/kg /day) orally concomitant with BL administration. Sperm count, motility, and viability were investigated and chromatin quality and DNA integrity were also analyzed. Serum testosterone and MDA concentrations were measured as well. Results: BL caused decline significantly (p<0.05) sperm count, sperm viability, motility as well as testosterone concentration compared to control group while significant (p<0.05) increases in immature sperm, sperm with damaged DNA and MDA concentration were announced in BL in comparison with CG and RJ+BLG. Royal jelly improved Bleomycin-induced toxicity on sperm parameters and testosterone and MDA concentrations. Conclusion: The present results support the idea that BL adversely affects sperm parameters and MDA and the RJ with antioxidant properties has positive effects on these parameters. This article extracted from M.Sc. thesis. (Tayebeh amirshahi) PMID:24799882

  19. Experiences of foreign European nurses in The Netherlands.

    PubMed

    de Veer, Anke; den Ouden, Dirk-Jan; Francke, Anneke

    2004-04-01

    As a result of the shortage of nurses, Dutch health care organizations want to recruit nurses from outside Europe (e.g. Indonesia, South Africa). The Dutch government, however, is not encouraging this policy and prefers to recruit within the European Union. In order to better support such nurses, it is important to know the problems European nurses encounter in The Netherlands. This study is about the experience of nurses from other European countries in The Netherlands. This paper addresses itself to three principal questions. First, how many nurses qualified in other EU or EU candidate states are starting to work in The Netherlands. Second, why do they come to The Netherlands. And finally what problems do they encounter when working in The Netherlands. A questionnaire has been send to all registered nurses trained in another EU or EU candidate state. The response has been 987 or 67%. Thus, far approximately 1500 nurses from other EU/candidate states have come to The Netherlands. Personal reasons, including marriage, are the most important reasons for their coming here. Half of the nurses took one or more courses before starting work in nursing in The Netherlands. These were often Dutch language courses. The nurses had to make a number of adjustments. Major difficulties were unfamiliarity with Dutch laws and the fiscal and social security systems, recognition of their qualifications and application for permits. Some basic issues, such as how to write a letter of application, caused problems. The language and unfamiliarity with the Dutch health care system made it difficult to find a job. When they had gained employment in nursing these problems remained the most serious. The conclusion is that international employment mobility in nursing is rather low in the case of The Netherlands. If the Dutch government decides to encourage the employment of nurses from abroad, several measures can be taken to make working in The Netherlands more attractive.

  20. At birth: the modern state, modern medicine, and the royal midwife Louise Bourgeois in seventeenth-century France.

    PubMed

    Sheridan, B

    1999-01-01

    In this article I explore the connections between state centralization, the professionalization of healing, and the end of the royal midwife Louise Bourgeois' (1563-1636) illustrious career in seventeenth-century France. Specifically, I analyze seventeenth-century narratives of two events which frame Louise Bourgeois' public career as a writer and royal midwife in order to demonstrate the way that the changing meanings of childbirth and the role of the midwife in the medical hierarchy were bound up in state formation and consolidation. The result for midwives was that, though they could still practice, they were ultimately considered marginal to the medical community.

  1. [Adaptation of Einthoven's string galvanometer for electrocardiography in the Netherlands].

    PubMed

    Wyers, P J

    2001-12-22

    After the Dutch physiologist Willem Einthoven (1860-1927) published the construction of his string galvanometer in 1901, the development of electrocardiography in the Netherlands was slow. During the next twenty years only a few string galvanometers were in use in the Netherlands, mostly in physiology laboratories. Publications concerning electrocardiographic tests on patients were scarce. In 1924, Einthoven was awarded the Nobel Prize for Physiology and Medicine for discovering the mechanism of the electrocardiogram. From that moment onwards, electrocardiography developed rapidly in the Netherlands and during the following 30 years particular use was made of the French string galvanometer designed by Boulitte.

  2. Serious road injuries in The Netherlands dissected.

    PubMed

    Weijermars, Wendy; Bos, Niels; Stipdonk, Henk L

    2016-01-01

    This article discusses the characteristics and injury patterns of serious road injuries (Maximum Abbreviated Injury Scale [MAIS] 2+ inpatients) in The Netherlands. In The Netherlands, the actual number of serious injuries is estimated by linking police data to hospital data. The distribution of serious road injuries over (1) travel mode and gender and (2) crash type and age are compared for the years 2000 and 2011. Moreover, the distribution of the injuries over the body regions is illustrated using colored injury body profiles. The number of serious injuries is higher for men than for women and increased from 16,500 in 2000 to 19,700 in 2011. In 2011, about half (51%) of the serious road injuries were due to a bicycle crash not involving a motor vehicle. The share of casualties aged 60 years and older is relatively high (43% in 2011) in these crashes. The injury body profiles show that head injuries (31%) and injuries to the lower extremities (37%) are most prevalent. Compared to other travel modes, pedestrians and riders of powered 2-wheelers relatively often sustain lower-leg injuries compared to other travel modes. Head injuries are most prevalent in cyclists who are injured in a crash with a motorized vehicle. Cyclists who are injured in a crash not involving a motor vehicle and casualties of 60 years and older relatively often include hip or upper-leg injuries. The characteristics of serious road injuries differ from those of fatalities and the distribution of injuries over the body differs by travel mode, gender, and age.

  3. Improving efficiency in robotic theatres in the Royal Wolverhampton NHS Trust: a gynaecology theatres perspective.

    PubMed

    Harding, V; Williams, J

    2016-03-01

    Improving efficiency within the operating theatre is always a key concern when running a successful operating list. However, with robotic surgery, this can become paramount. Robotic procedures require a more technical set up, additional planning, and good solid communication within the multidisciplinary team. Efficiency needs to be at the forefront of everyone's mind. Forward planning requires knowledge of the procedures being carried out and adequate training with the robot. Trouble shooting will also improve efficiency in robotic surgery, as being able to expect the unexpected can be a major advantage. This article looks at the hurdles encountered by the theatre team at Royal Wolverhampton Trust at the implementation of the robotic programme, and how the theatre team made adjustments to working practice in order to minimise disruption and maximise efficiency.

  4. Profile: Vanessa Cameron – 36 years at the Royal College of Psychiatrists

    PubMed Central

    Poole, Rob; Robinson, Catherine A.

    2016-01-01

    On 16 December 2016, Vanessa Cameron retires as Chief Executive of the Royal College of Psychiatrists. She started working there in September 1980 and in 1984 she became Secretary of the College, the role that preceded chief executive. The College was formed in 1971, so Vanessa has been present for most of its lifetime. It has been a period of continuous change that has seen psychiatry leave the old mental hospitals, expand considerably in the late 1990s and early part of the 21st century, and come under huge pressure more recently. Although she has never worked within mental health services, Vanessa has been at the heart of British psychiatry for 36 years. She was awarded an MBE in the 2013 New Year's Honours list for services to psychiatry. We interviewed Vanessa at 21 Prescot Street on 3 August 2016. PMID:28377815

  5. The royal road for genetic algorithms: Fitness landscapes and GA performance

    SciTech Connect

    Mitchell, M.; Holland, J.H. ); Forrest, S. . Dept. of Computer Science)

    1991-01-01

    Genetic algorithms (GAs) play a major role in many artificial-life systems, but there is often little detailed understanding of why the GA performs as it does, and little theoretical basis on which to characterize the types of fitness landscapes that lead to successful GA performance. In this paper we propose a strategy for addressing these issues. Our strategy consists of defining a set of features of fitness landscapes that are particularly relevant to the GA, and experimentally studying how various configurations of these features affect the GA's performance along a number of dimensions. In this paper we informally describe an initial set of proposed feature classes, describe in detail one such class ( Royal Road'' functions), and present some initial experimental results concerning the role of crossover and building blocks'' on landscapes constructed from features of this class. 27 refs., 1 fig., 5 tabs.

  6. The logic of scientific unity? Medawar, the Royal Society and the Rothschild controversy 1971–72

    PubMed Central

    Calver, Neil; Parker, Miles

    2016-01-01

    In 1971 Lord (Victor) Rothschild published his report for the government, The organisation and management of government R&D, and Sir Peter Medawar launched a campaign for the election of Sir Karl Popper to Fellowship of the Royal Society. We explore these two developments in the contexts of the then current views of the role and purpose of science, and their underpinning philosophy. Although the political battle was won by Rothschild, resulting in major changes to the funding and management of applied R&D, we argue that, despite this, Medawar's campaign for Popper provided an embattled science community with a philosophical basis for defending pure research and the unity of basic and applied science. PMID:27017681

  7. The Royal Princess Anna Vasa. Historical note and radiological examination of her skeleton.

    PubMed

    Grzegorzewski, M; Borón, Z; Lasek, W; Florkowski, A

    1996-03-01

    Radiological findings on the skeleton of the Royal Princess Anna Vasa are presented. Anna Vasa (1568-1625) was the sister of Sigismund Vasa, who reigned as Sigismund III, king of Sweden and Poland. She was born in Sweden but spent most of her life in Poland. Her skeleton was removed from the tomb in Toruń during restoration work at St. Mary's Church in April 1994. It was then subjected to anthropological and radiological examinations (conventional radiography and CT). The studies revealed a number of anatomical deviations and pathological abnormalities; e.g. basilar impression and congenital anomalies of the spine. These findings can explain many of the complaints troubling Anna Vasa during her lifetime. A fragmentary historical outline and biography of Anna Vasa and Sigismund III are also presented.

  8. The discovery of microorganisms by Robert Hooke and Antoni Van Leeuwenhoek, fellows of the Royal Society.

    PubMed

    Gest, Howard

    2004-05-01

    The existence of microscopic organisms was discovered during the period 1665-83 by two Fellows of The Royal Society, Robert Hooke and Antoni van Leeuwenhoek. In Micrographia (1665), Hooke presented the first published depiction of a microganism, the microfungus Mucor. Later, Leeuwenhoek observed and described microscopic protozoa and bacteria. These important revelations were made possible by the ingenuity of Hooke and Leeuwenhoek in fabricating and using simple microscopes that magnified objects from about 25-fold to 250-fold. After a lapse of more than 150 years, microscopy became the backbone of our understanding of the roles of microbes in the causation of infectious diseases and the recycling of chemical elements in the biosphere.

  9. Management practices that concentrate visitor activities: Camping impact management at Isle Royale National Park, USA

    USGS Publications Warehouse

    Marion, J.L.; Farrell, T.A.

    2002-01-01

    This study assessed campsite conditions and the effectiveness of campsite impact management strategies at Isle Royale National Park, USA. Protocols for assessing indicators of vegetation and soil conditions were developed and applied to 156 campsites and 88 shelters within 36 backcountry campgrounds. The average site was 68 m2 and 83% of sites lost vegetation over areas less than 47 m2. Results reveal that management actions to spatially concentrate camping activities and reduce camping disturbance have been highly successful. Comparisons of disturbed area/overnight stay among other protected areas reinforces this assertion. These reductions in area of camping disturbance are attributed to a designated site camping policy, limitation on site numbers, construction of sites in sloping terrain, use of facilities, and an ongoing program of campsite maintenance. Such actions are most appropriate in higher use backcountry and wilderness settings.

  10. Telecommunications model for continuing education of health professionals: the Royal Brompton case.

    PubMed

    Kotis, Takis

    2003-01-01

    Telemedicine is said to be helpful to both patients and providers, but we need real-world examples to demonstrate its effectiveness. This paper presents such an example. Royal Brompton, under the Tele-remedy Program of EC Telecom, conducted a project with the Children's Hospital of Athens, Greece, to provide remote diagnosis management and continuing education for heart disease, using European ISDN technology. Preliminary results showed that, when carried out in a large scale multi-site environment, Teleremedy program significantly reduced geographic and socio-economic isolation for the patient and the professional isolation for the physician. Comparison of original vs. transmitted data revealed no significant differences, with diagnosis accuracy of 100%.

  11. AN AUTOPSIC ART: DRAWINGS OF 'DR GRANVILLE'S MUMMY' IN THE ROYAL SOCIETY ARCHIVES.

    PubMed

    Riggs, Christina

    2016-06-20

    In 1821 Augustus Bozzi Granville FRS unwrapped and dissected an ancient Egyptian mummy, presenting the results of his examination to the Royal Society in 1825. He commissioned artist Henry Perry to draw the process in stages; these drawings were subsequently engraved by James Basire for publication in Philosophical Transactions. This article presents the original drawings for the first time, allowing comparison with their engravings. Taken together with Granville's accounts of the unwrapping of the mummy, the drawings demonstrate the significant role of illustration and other visual practices in anatomical argumentation in the early nineteenth century, as well as the prestige that commissioned illustrations lent to the performance and dissemination of scientific expertise. Moreover, the drawings include one of the key visual tropes of race science--a skull in left-facing profile, mapped with a facial angle--and thus indicate the early incorporation of Egyptian mummies into typologies of race.

  12. An autopsic art: drawings of ‘Dr Granville's mummy’ in the Royal Society archives

    PubMed Central

    Riggs, Christina

    2016-01-01

    In 1821 Augustus Bozzi Granville FRS unwrapped and dissected an ancient Egyptian mummy, presenting the results of his examination to the Royal Society in 1825. He commissioned artist Henry Perry to draw the process in stages; these drawings were subsequently engraved by James Basire for publication in Philosophical Transactions. This article presents the original drawings for the first time, allowing comparison with their engravings. Taken together with Granville's accounts of the unwrapping of the mummy, the drawings demonstrate the significant role of illustration and other visual practices in anatomical argumentation in the early nineteenth century, as well as the prestige that commissioned illustrations lent to the performance and dissemination of scientific expertise. Moreover, the drawings include one of the key visual tropes of race science—a skull in left-facing profile, mapped with a facial angle—and thus indicate the early incorporation of Egyptian mummies into typologies of race. PMID:27386713

  13. Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish

    SciTech Connect

    Paul E. Drevnick; Donald E. Canfield; Patrick R. Gorski

    2007-11-01

    Mercury contamination of fish is a global problem. Consumption of contaminated fish is the primary route of methylmercury exposure in humans and is detrimental to health. Newly mandated reductions in anthropogenic mercury emissions aim to reduce atmospheric mercury deposition and thus mercury concentrations in fish. However, factors other than mercury deposition are important for mercury bioaccumulation in fish. In the lakes of Isle Royale, U.S.A., reduced rates of sulfate deposition since the Clean Air Act of 1970 have caused mercury concentrations in fish to decline to levels that are safe for human consumption, even without a discernible decrease in mercury deposition. Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters. 71 refs., 3 figs., 1 tab.

  14. Lessons From a 17-Year Radiosurgery Experience at the Royal Adelaide Hospital

    SciTech Connect

    Roos, Daniel E.; Brophy, Brian P.; Taylor, James

    2012-01-01

    Purpose: To illustrate some of the potential pitfalls of cranial stereotactic radiosurgery (SRS) and its planning based on prospectively gathered data from a 17-year experience at the Royal Adelaide Hospital. Methods and Materials: More than 250 treatments have been planned since 1993 using previously described standard SRS techniques for intracranial benign and malignant lesions. Results: Five case studies are presented (1 meningioma, 1 acoustic neuroma, 2 solitary brain metastasis, 1 arteriovenous malformation), each of which demonstrates at least one salutary lesson. Conclusions: Because SRS delivers a highly conformal dose distribution, it is unforgiving of any geographic miss due to inaccurate outlining and thus dependent on neuroradiological expertise and collaboration. There are also potentially significant implications of misdiagnosis in SRS cases without histological proof-in particular, presumed brain metastases.

  15. Molecular characterization of MRJP3, highly polymorphic protein of honeybee (Apis mellifera) royal jelly.

    PubMed

    Albert, S; Klaudiny, J; Simúth, J

    1999-05-01

    Major proteins of honey bee (Apis mellifera) royal jelly are members of the MRJP protein family. One MRJP protein termed MRJP3 exhibits a size polymorphism as detected by SDS-PAGE. In this report we show that polymorphism of the MRJP3 protein is a consequence of the polymorphism of a region with a variable number of tandem repeats (VNTR) located at the C-terminal part of the MRJP3 coding region. We present the characterization of five polymorphic alleles of MRJP3 by DNA sequencing. By PCR analyses, at least 10 alleles of distinct sizes were found in randomly sampled bees. Studies with nurse bees from a single honeybee colony revealed both Mendelian inheritance and very high variability of the MRJP3 genomic locus. The high variability and simple detection of the MRJP3 polymorphism may be useful for genotyping of individuals in studies of the honeybee.

  16. The Royal Philanthropic Expedition of the Vaccine: a landmark in the history of public health.

    PubMed

    Soto-Pérez-de-Celis, E

    2008-11-01

    In 1979, smallpox officially became the first disease ever to be eradicated by mankind. The global efforts to defeat this dreadful pandemic, however, started almost two centuries before. One of the most important, and sometimes forgotten, events in the fight against smallpox was the Royal Philanthropic Expedition of the Vaccine, commissioned by Charles IV of Spain to physicians Francisco Xavier Balmis y Berenguer and Jose Salvany in 1804. The aim of this expedition was to take the smallpox vaccine, discovered by Jenner, to Spain's territories in the Americas and in the Far East. After several years of vaccination in modern day Puerto Rico, Cuba, Venezuela, Ecuador, Peru, Bolivia, Chile, Mexico and the Philippines, the expedition returned to Europe. To this day, the Balmis and Salvany expedition remains a great example of international cooperation, and a landmark in the history of public health.

  17. Exploring and communicating knowledge of trees in the early royal society.

    PubMed

    Hartley, Beryl

    2010-09-20

    For nearly 150 years after its foundation, Fellows of the Royal Society collected information on trees, investigated their anatomy and physiology, promoted planting and improved planting practices, and introduced, naturalized and classified foreign species. Their discoveries and advice were widely disseminated and used. Historians have generally neglected this interest, although the Society's first publication was an influential work on trees. They have also overlooked the significance of Stephen Hales's remark in Vegetable Staticks--that he hoped his enquiries into the nature of plants would improve skills in agriculture and gardening-and his linking of sap movement to tree pruning. Fellows' experiments and field trials not only advanced knowledge of the structure, nutrition and growth of trees but also provided empirical evidence supporting instructions for cultivating them.

  18. Tracer simulation study of potential solute movement in Port Royal Sound, South Carolina

    USGS Publications Warehouse

    Kilpatrick, F.A.; Cummings, T. Ray

    1972-01-01

    A tracer study was conducted in Port Royal Sound to simulate the movement and ultimate pattern of concentration of a solute continuously injected into the flow. A total of 750 pounds of Rhodamine WT dye was injected by boat during a period of 24.8 hours in a line across the Colleton River. During the following 43 days, samples of water were taken at selected points in the sound, and the concentration of dye in the samples was determined by fluorometric analysis. The data obtained in the field study were used with theoretical models to compute the ultimate pattern of concentration of nonconservative and conservative solutes for a hypothetical continuous injection at the site on the Colleton River.

  19. The letter from Dublin: climate change, colonialism, and the Royal Society in the seventeenth century.

    PubMed

    Vogel, Brant

    2011-01-01

    This article discusses an anonymous letter published in the Philosophical Transactions in 1676 that reports the theories of American colonists about the cause of their warming climate (cultivation and deforestation), and offers Ireland's colonial experience as a counterexample: Ireland was a colony with decreased cultivation, but the same perceived warming. That such an objection seemed necessary to the author shows that anthropogenic climate change could be a subject of debate and that the concept of climate was tied into theories of land use and to the colonial enterprise. Since he was liminal to both the Royal Society of London and the intellectual circles of Dublin, his skepticism, contextualized here, questions both the elite discourse and the discourse at the colonial periphery.

  20. Characterisation of particulate matter in the Royal Museum of Fine Arts, Antwerp, Belgium

    NASA Astrophysics Data System (ADS)

    Gysels, Kristin; Deutsch, Felix; Grieken, René Van

    Aerosol samples were collected during two campaigns in February and July 1999 both inside and outside the Koninklijk Museum voor Schone Kunsten (KMSK, Royal Museum of Fine Arts) in Antwerp. Bulk aerosol concentrations, as well as the composition of the individual particles, were determined. The influence of the outdoor aerosol was clearly visible. In winter, restoration and construction works constituted an additional indoor source of Ca-rich and Ca-Si particles. Along with sea salt, these were the main particle types identified in this season. In summer, S-rich particles were most frequent. The summer abundances of Ca-rich particles remained low, even though the museum is situated in a limestone building. Moreover, dry deposition samples were collected in order to determine what amount of particles could actually be deposited onto the works of art.

  1. Retrospective Analysis of Patient Presentations at the Sydney (Australia) Royal Easter Show from 2012 to 2014.

    PubMed

    Crabtree, Nathan; Mo, Shirley; Ong, Leon; Jegathees, Thuvarahan; Wei, Daniel; Fahey, David; Liu, Jia Jenny

    2017-04-01

    Introduction Comprehensive studies on the relationship between patient demographics and subsequent treatment and disposition at a single mass-gathering event are lacking. The Sydney Royal Easter Show (SRES; Sydney Olympic Park, New South Wales, Australia) is an annual, 14-day, agricultural mass-gathering event occurring around the Easter weekend, attracting more than 800,000 patrons per year. In this study, patient records from the SRES were analyzed to examine relationships between weather, crowd size, day of week, and demographics on treatment and disposition. This information would help to predict factors affecting patient treatment and disposition to guide ongoing training of first responders and to evaluate the appropriateness of staffing skills mix at future events. Hypothesis Patient demographics, environmental factors, and attendance would influence the nature and severity of presentations at the SRES, which would influence staffing requirements.

  2. Sir Robert Stawell Ball (1840-1913): Royal Astronomer in Ireland and astronomy's public voice

    NASA Astrophysics Data System (ADS)

    Chapman, Allan

    2007-11-01

    Nineteenth-century Ireland, and especially Dublin, had a vibrant scientific tradition. And astronomy in particular was seriously cultivated, being part of an Irish tradition extending back to early medieval times. This paper examines principally the career of Sir Robert Stawell Ball, who, while holding three prestigious posts in Ireland, namely those of Andrews Professor at Trinity College, Dublin, Royal Astronomer of Ireland, and Director of the Dunsink Observatory, became famous for his genius as a popular astronomical interpreter, lecturer, and writer. The paper looks at Ball's wider career, the circumstances that provided a receptive market for astronomical information across the English-speaking world, and his massive outreach as both a lecturer and a writer.

  3. The Phenotypic Effects of Royal Jelly on Wild-Type D. melanogaster Are Strain-Specific

    PubMed Central

    Morgan, Stefanie L.; Seggio, Joseph A.; Hicks, Jasmin A.; Sharp, Katherine A.; Axelrod, Jeffrey D.; Wang, Kevin C.

    2016-01-01

    The role for royal jelly (RJ) in promoting caste differentiation of honeybee larvae into queens rather than workers is well characterized. A recent study demonstrated that this poorly understood complex nutrition drives strikingly similar phenotypic effects in Drosophila melanogaster, such as increased body size and reduced developmental time, making possible the use of D. melanogaster as a model system for the genetic analysis of the cellular mechanisms underlying RJ and caste differentiation. We demonstrate here that RJ increases the body size of some wild-type strains of D. melanogaster but not others, and report significant delays in developmental time in all flies reared on RJ. These findings suggest that cryptic genetic variation may be a factor in the D. melanogaster response to RJ, and should be considered when attempting to elucidate response mechanisms to environmental changes in non-honeybee species. PMID:27486863

  4. [Aldo Castellani and the expeditions of the Royal Society to the black sleep's country].

    PubMed

    Ledermann D, Walter

    2011-06-01

    At the beginning the investigation on infectious diseases was plenty of adventures in exotic countries. The efforts of the English investigators, headed by Patrick Manson, gave birth to the "tropical" medicine and "tropical" diseases, like the sleeping sickness, which was sweeping the country north to the Victoria Lake in 1901. The Royal Society of London sent two Commissions in search of the etiological agent. Aldo Castellani was decisive for the failure of the first - Low, Castellani, Christy,1902 - because even he saw Trypanosoma in samples of some patients, he did not appreciate his discovery; and decisive also for the success of the second -Bruce, Nabarro, Greig, 1903 - when he and Bruce recognized this Trypanosoma as the etiological agent. Following these expeditions, Low developed a brilliant career in England, Christy a life of investigation mixed up with adventures through Asia and Africa and Castellani a long life of lights and shadows in many lands.

  5. A Third Analysis of Officer Resignation from the Royal Australian Navy

    DTIC Science & Technology

    1989-04-01

    I . vA., C Q\\ I DPSYCH-N R/N 2/891 ( A Third Analysis of I Officer Resignation 0) from the I N Royal Australian Navy N I I by R.G. SALAS I Area...APPROVED FOR PUB3LC rr-’FAQ’ 90 y L\\, ili AL 149 Depatimert of Defence Page Clasfication Fte~tsec May 86 DOCUMENT CONTROL DATA Ia A R Numbe lb Establishment...Numbei 2 Document Date 3. Task Numbe 005-839 DPSYCH-N R/N 2/89 4, Title 5, Secuhty Classification 6 No Paqje.I A Third Analysis of Officer "Plce app

  6. THE LOGIC OF SCIENTIFIC UNITY? MEDAWAR, THE ROYAL SOCIETY AND THE ROTHSCHILD CONTROVERSY 1971-72.

    PubMed

    Calver, Neil; Parker, Miles

    2016-03-20

    In 1971 Lord (Victor) Rothschild published his report for the government, The organisation and management of government R&D, and Sir Peter Medawar launched a campaign for the election of Sir Karl Popper to Fellowship of the Royal Society. We explore these two developments in the contexts of the then current views of the role and purpose of science, and their underpinning philosophy. Although the political battle was won by Rothschild, resulting in major changes to the funding and management of applied R&D, we argue that, despite this, Medawar's campaign for Popper provided an embattled science community with a philosophical basis for defending pure research and the unity of basic and applied science.

  7. Royal sun medicinal mushroom, Agaricus brasiliensis Ka21 (higher Basidiomycetes), as a functional food in humans.

    PubMed

    Yamanaka, Daisuke; Liu, Ying; Motoi, Masuro; Ohno, Naohito

    2013-01-01

    The Royal Sun medicinal mushroom, Agaricus brasiliensis, is used as a natural health product. In Japan, however, the quality control of some of these mushroom products has been viewed as a safety problem. Focusing on the quality control of A. brasiliensis KA21, we have performed several safety studies. To date, we have established evidence that this mushroom can be used safely as an immunostimulant and to mediate biochemical parameters associated with obesity or diabetes. Furthermore, to improve the manufacturing process of this mushroom, we have studied the relationship between its pharmaceutical actions and the conditions of its cultivation and thermal management. The purpose of this review is to report the findings of basic and clinical studies of the fruit body of A. brasiliensis KA21.

  8. Sir Harry C Sinderson Pasha (1891-1974): physician, medical educator and royal confidant.

    PubMed

    Jawad, A S

    2013-01-01

    Following the end of the First World War, several British orientalists had a significant influence on politics and development in a number of Arab countries in the Middle East. These include familiar figures such as TE Lawrence in Hejaz, Jordan and Syria, Gertrude Bell in Iraq, Harry St John Philby (later Sheikh Abdullah) in Saudi Arabia and Sir John Glubb (Glubb Pasha) in Jordan. There are however other less well-known individuals, of whom Harry Sinderson Pasha is one. Sinderson was a physician who played a significant role in the development of health and medical education in modern Iraq after it was established by the British in 1920. He was personal physician to the Royal family of Iraq, a confidant to King Faisal I and then to the Prince Regent, and he played an important role in the politics of that period.

  9. History of the Royal College of Chiropractic Sports Sciences (Canada): the early years

    PubMed Central

    De Finney, John; Lawson, Gordon; Gryfe, David; Gillis-Lawson, Susan; Crawford, John P.

    2016-01-01

    In 1978 the Canadian Chiropractic Association recognized the need to establish an organization that would prepare chiropractors to treat athletic injuries and promote these services to sports organizations. Dr. Adrian Grice approached three chiropractors to establish such an organization. The Canadian Chiropractic Sports Academy (CCSA) was established in 1978. This was the start of the chiropractic sports movement which has seen chiropractors playing prominent roles as team doctors to professional and amateur teams and athletes and in the delivery of care at major national and international competitions. This paper will show the work done by the original founders of the CCSA which has helped to pave the way to the present level of acceptance of chiropractic sports injury management and performance enhancement and as the progenitor of the Royal College of Chiropractic Sports Sciences Canada. PMID:28065996

  10. Purification, crystallization and preliminary X-ray diffraction analysis of royal palm tree (Roystonea regia) peroxidase

    PubMed Central

    Watanabe, Leandra; Nascimento, Alessandro S.; Zamorano, Laura S.; Shnyrov, Valery L.; Polikarpov, Igor

    2007-01-01

    Royal palm tree peroxidase (RPTP), which was isolated from Roystonea regia leaves, has an unusually high stability that makes it a promising candidate for diverse applications in industry and analytical chemistry [Caramyshev et al. (2005 ▶), Biomacromolecules, 6, 1360–1366]. Here, the purification and crystallization of this plant peroxidase and its X-ray diffraction data collection are described. RPTP crystals were obtained by the hanging-drop vapour-diffusion method and diffraction data were collected to a resolution of 2.8 Å. The crystals belong to the trigonal space group P3121, with unit-cell parameters a = b = 116.83, c = 92.24 Å, and contain one protein molecule per asymmetric unit. The V M value and solvent content are 4.07 Å3 Da−1 and 69.8%, respectively. PMID:17768354

  11. Organochlorine and metal residues in royal terns nesting on the central Texas coast

    USGS Publications Warehouse

    King, K.A.; LeFever, C.A.; Mulhern, B.M.

    1982-01-01

    Royal Tern (Sterna maxima) eggs collected from two study areas on the central Texas coast in 1978 contained organochlorine residues at levels below those known to have adverse effects on avian reproduction and survival. Residues of zinc, copper, selenium, and arsenic were present at what appeared to be background levels. Mercury residues were elevated. Average organochlorine and metals residues did not differ significantly between an agricultural-industrial study area and a less developed control area. The thickness of eggshells collected in 1978 was statistically similar to the thickness of shells collected before 1943. There was a significant improvement in mean eggshell thickness from 1970 to 1978 with a corresponding decline in DDE and PCB residues.

  12. Purification, crystallization and preliminary X-ray diffraction analysis of royal palm tree (Roystonea regia) peroxidase.

    PubMed

    Watanabe, Leandra; Nascimento, Alessandro S; Zamorano, Laura S; Shnyrov, Valery L; Polikarpov, Igor

    2007-09-01

    Royal palm tree peroxidase (RPTP), which was isolated from Roystonea regia leaves, has an unusually high stability that makes it a promising candidate for diverse applications in industry and analytical chemistry [Caramyshev et al. (2005), Biomacromolecules, 6, 1360-1366]. Here, the purification and crystallization of this plant peroxidase and its X-ray diffraction data collection are described. RPTP crystals were obtained by the hanging-drop vapour-diffusion method and diffraction data were collected to a resolution of 2.8 A. The crystals belong to the trigonal space group P3(1)21, with unit-cell parameters a = b = 116.83, c = 92.24 A, and contain one protein molecule per asymmetric unit. The V(M) value and solvent content are 4.07 A3 Da(-1) and 69.8%, respectively.

  13. History of the Royal College of Chiropractic Sports Sciences (Canada): the early years.

    PubMed

    De Finney, John; Lawson, Gordon; Gryfe, David; Gillis-Lawson, Susan; Crawford, John P

    2016-12-01

    In 1978 the Canadian Chiropractic Association recognized the need to establish an organization that would prepare chiropractors to treat athletic injuries and promote these services to sports organizations. Dr. Adrian Grice approached three chiropractors to establish such an organization. The Canadian Chiropractic Sports Academy (CCSA) was established in 1978. This was the start of the chiropractic sports movement which has seen chiropractors playing prominent roles as team doctors to professional and amateur teams and athletes and in the delivery of care at major national and international competitions. This paper will show the work done by the original founders of the CCSA which has helped to pave the way to the present level of acceptance of chiropractic sports injury management and performance enhancement and as the progenitor of the Royal College of Chiropractic Sports Sciences Canada.

  14. Seventeenth-century 'treasure' found in Royal Society archives: the Ludus helmontii and the stone disease.

    PubMed

    Alfonso-Goldfarb, Ana Maria; Ferraz, Márcia Helena Mendes; Rattansi, Piyo M

    2014-09-20

    Our archival researches at the Royal Society reveal that a small envelope attached to a 1675 letter from an Antwerp apothecary, A. Boutens, contained a sample of the 'Ludus' prepared as a remedy for the 'stone disease' then sweeping through Europe, which was first announced in J. B. van Helmont's De lithiasi (1644). After examining the fascination with the medical use of the Ludus (which required the 'alkahest' for its preparation) and the tenacious efforts to procure it, we trace the fortunae of two other ludi in England, brought to and offered by Francis Mercurius van Helmont during his English sojourn. Both eventually found their way to the geologist John Woodward, one of them through Sir Isaac Newton. Finally we show how the allure of the Ludus helmontii vanished, with transformations in mineral analysis and reclassifications from Woodward to John Hill.

  15. Genomic Variation of Inbreeding and Ancestry in the Remaining Two Isle Royale Wolves.

    PubMed

    Hedrick, Philip W; Kardos, Marty; Peterson, Rolf O; Vucetich, John A

    2017-03-01

    Inbreeding, relatedness, and ancestry have traditionally been estimated with pedigree information, however, molecular genomic data can provide more detailed examination of these properties. For example, pedigree information provides estimation of the expected value of these measures but molecular genomic data can estimate the realized values of these measures in individuals. Here, we generate the theoretical distribution of inbreeding, relatedness, and ancestry for the individuals in the pedigree of the Isle Royale wolves, the first examination of such variation in a wild population with a known pedigree. We use the 38 autosomes of the dog genome and their estimated map lengths in our genomic analysis. Although it is known that the remaining wolves are highly inbred, closely related, and descend from only 3 ancestors, our analyses suggest that there is significant variation in the realized inbreeding and relatedness around pedigree expectations. For example, the expected inbreeding in a hypothetical offspring from the 2 remaining wolves is 0.438 but the realized 95% genomic confidence interval is from 0.311 to 0.565. For individual chromosomes, a substantial proportion of the whole chromosomes are completely identical by descent. This examination provides a background to use when analyzing molecular genomic data for individual levels of inbreeding, relatedness, and ancestry. The level of variation in these measures is a function of the time to the common ancestor(s), the number of chromosomes, and the rate of recombination. In the Isle Royale wolf population, the few generations to a common ancestor results in the high variance in genomic inbreeding. © The American Genetic Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats

    PubMed Central

    Ghanbari, Elham; Nejati, Vahid; Khazaei, Mozafar

    2016-01-01

    Background: Diabetes is the most common endocrine disease. It has adverse effects on male reproductive function. Royal Jelly (RJ) has antioxidant and anti-diabetic effects and show protective effects against diabetes. Objective: This study was conducted to evaluate the effect of RJ on histopathological alterations of the testicular tissue in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In this experimental study, 28 adult Wistar rats were randomly divided into control (C), royal jelly (R), diabetic (D) and RJ-treated diabetic (D+R) groups. Diabetes was induced by a single intraperitoneal injection of STZ at 50 mg/kg body weight (BW). The rats from the R and D+R groups received daily RJ (100 mg/kg BW) for 6 wks orally. Hematoxylin-Eosin staining was used to analyze histopathological changes including: tunica albuginea thickness (TAT), seminiferous tubules diameter (STsD), Johnsen’s score, tubular differentiation index (TDI), spermiogenesis index (SPI), Sertoli cell index (SCI), meiotic index (MI), and mononuclear immune cells (MICs) in testes. The antioxidant status was examined by evaluating testicular levels of ferric reducing antioxidant power (FRAP) and catalase (CAT) activity. Results: Histological results of the testis from diabetic rats showed significant decrease in STsD, Johnsen’s score, TDI, SPI, SCI and MI, and significant increase in TAT and MICs, while administration of RJ significantly reverted these changes (p<0.05). RJ treatment markedly increased activity of CAT and FRAP. There were significant differences in FRAP levels among C (13.0±0.5), RJ (13.4±0.3), D (7.8±0.6) and D+R (12.4±0.7) groups (p<0.05). Conclusion: RJ improved diabetes-induced impairment in testis, probably through its antioxidant property. PMID:27679827

  17. Effect of Royal Jelly on Formalin Induced-Inflammation in Rat Hind Paw

    PubMed Central

    Arzi, Ardeshir; Olapour, Samaneh; Yaghooti, Hamid; Sistani Karampour, Neda

    2015-01-01

    Background: Royal Jelly (RJ), a food item secreted by worker honeybees, is a mixture that contains protein, glucose, lipid, vitamins, and minerals; it is widely used as a commercial medical product. Previous studies have shown that RJ has a number of physiological effects, such as anti-inflammatory, antitumor, antiallergic and antioxidant activities. Objectives: In the present study, the anti-inflammatory properties of RJ were investigated in formalin-induced rat paw edema. Materials and Methods: In this study, 30 male Wistar albino rats were divided into five equal groups (n = 6) as follows: test groups received different doses (25, 50 and 100 mg/kg, ip) of RJ and a negative control group received normal saline (5 mL/kg) and a positive control group received aspirin (300 mg/kg, i.p). Edema was induced on the right hind paw of the rat by a subplantar injection of 100 µL of formalin (2.5%) after 30 minutes. Paw edema was measured in the rats received the drugs, saline and aspirin before and after the formalin injection during 5 hours, using a plethysmometer. Results: The results showed that RJ has a dose-dependent anti-inflammatory effect and the highest anti-inflammatory effect was observed in the doses of 50 and 100 mg/kg. Conclusions: Royal jelly has potent anti-inflammatory effects compared to aspirin and it could be used in the treatment of inflammation. However, further studies are required to determine the active components in RJ responsible for this effect and its mechanism of action. PMID:25866724

  18. The Royal College of Radiologists' audit of prostate brachytherapy in the year 2012.

    PubMed

    Stewart, A J; Drinkwater, K J; Laing, R W; Nobes, J P; Locke, I

    2015-06-01

    This audit provides a comprehensive overview of UK prostate brachytherapy practice in the year 2012, measured against existing standards, immediately before the introduction of new Royal College of Radiologists (RCR) guidelines. This audit allows comparison with European and North American brachytherapy practice and for the impact of the RCR 2012 guidelines to be assessed in the future. A web-based data collection tool was developed by the RCR Clinical Audit Committee and sent to audit leads at all cancer centres in the UK. Standards were developed based on available guidelines in use at the start of 2012 covering case mix and dosimetry. Further questions were included to reflect areas of anticipated change with the implementation of the 2012 guidelines. Audit findings were compared with similar audits of practice in Europe, the USA and Latin America. Forty-nine of 59 cancer centres submitted data. Twenty-nine centres reported carrying out prostate brachytherapy; of these, 25 (86%) provided data regarding the number of implants, staffing, dosimetry, medication and anaesthesia and follow-up. Audit standards achieved excellent compliance in most areas, although were low in post-implant dosimetry and in post-implant scanning at 30 days. This audit provides a comprehensive picture of prostate brachytherapy in the UK in 2012. Patterns of care of prostate brachytherapy are similar to practice in the USA and Europe. The number of prostate brachytherapy implants carried out in the UK has grown significantly since a previous RCR audit in 2005 and it is important that centres maintain minimum numbers of cases to ensure that experience can be maintained and compliance to guidelines achieved. Copyright © 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  19. Royal jelly proteome comparison between A. mellifera ligustica and A. cerana cerana.

    PubMed

    Yu, Fang; Mao, Feng; Jianke, Li

    2010-05-07

    In this study, we compared royal jelly (RJ) produced by Apis mellifera ligustica and Apis cerana cerana in production, protein profiles, and abundances using proteomic approaches. The RJ proteome was displayed using two-dimensional gel electrophoresis (2DGE), and proteins were identified using MALDI-TOF MS and LC-Chip/ESI-QTOF MS. Differences in the RJ proteome between the two bee species were validated using western-blot analysis. RJ production by A. cerana cerana (3.21 +/- 0.43 g) is significantly lower than that of A. mellifera ligustica (80.5 +/- 7.83 g). The 2DGE based MS approach identified 52 and 60 proteins in the RJ of A. mellifera ligustica and A. cerana cerana, respectively. The majority of the identified proteins were major royal jelly proteins (MRJPs). Peroxiredoxin 2540, glutathione S-transferase S1, and MRJP5 were detected only in the RJ of A. mellifera ligustica, and MRJP1 was the most abundant MRJP. In contrast, MRJP7 was found only in the RJ of A. cerana cerana. But, similar to A. mellifera ligustica, MRJP1 was found most abundantly in this case too. In this study, glucose oxidase was identified for the first time in the A. cerana cerana RJ. Comparing the protein levels of MRJP1, 2, 3, 4, and 5 between the two species, they were significantly higher in the RJ of A. mellifera ligustica than in A. cerana cerana. This observation was supported by Western blot analysis using anti-MRJP1, 2, 3 antibodies. The result suggested that A. mellifera ligustica needs more nutrition to nurse the developing larvae and queens as compared to that of A. cerana cerana. This study improved our understanding of protein composition of RJ from Western and Eastern honeybees. RJ produced by A. mellifera ligustica exceeds the RJ from A. cerana cerana both in terms of production and health purposes.

  20. Crystal structure and statistical coupling analysis of highly glycosylated peroxidase from royal palm tree (Roystonea regia).

    PubMed

    Watanabe, Leandra; de Moura, Patricia Ribeiro; Bleicher, Lucas; Nascimento, Alessandro S; Zamorano, Laura S; Calvete, Juan J; Sanz, Libia; Pérez, Alicia; Bursakov, Sergey; Roig, Manuel G; Shnyrov, Valery L; Polikarpov, Igor

    2010-02-01

    Royal palm tree peroxidase (RPTP) is a very stable enzyme in regards to acidity, temperature, H(2)O(2), and organic solvents. Thus, RPTP is a promising candidate for developing H(2)O(2)-sensitive biosensors for diverse applications in industry and analytical chemistry. RPTP belongs to the family of class III secretory plant peroxidases, which include horseradish peroxidase isozyme C, soybean and peanut peroxidases. Here we report the X-ray structure of native RPTP isolated from royal palm tree (Roystonea regia) refined to a resolution of 1.85A. RPTP has the same overall folding pattern of the plant peroxidase superfamily, and it contains one heme group and two calcium-binding sites in similar locations. The three-dimensional structure of RPTP was solved for a hydroperoxide complex state, and it revealed a bound 2-(N-morpholino) ethanesulfonic acid molecule (MES) positioned at a putative substrate-binding secondary site. Nine N-glycosylation sites are clearly defined in the RPTP electron-density maps, revealing for the first time conformations of the glycan chains of this highly glycosylated enzyme. Furthermore, statistical coupling analysis (SCA) of the plant peroxidase superfamily was performed. This sequence-based method identified a set of evolutionarily conserved sites that mapped to regions surrounding the heme prosthetic group. The SCA matrix also predicted a set of energetically coupled residues that are involved in the maintenance of the structural folding of plant peroxidases. The combination of crystallographic data and SCA analysis provides information about the key structural elements that could contribute to explaining the unique stability of RPTP.

  1. Institute Study Report

    NASA Technical Reports Server (NTRS)

    Whitaker, Ann; Steadman, Jackie; Little, Sally; Underwood, Debra; Blackman, Mack; Simonds, Judy

    1997-01-01

    This report documents a study conducted by the MSFC working group on Institutes in 1995 on the structure, organization and business arrangements of Institutes at a time when the agency was considering establishing science institutes. Thirteen institutes, ten science centers associated with the state of Georgia, Stanford Research Institute (SRI), and IIT Research Institute (IITRI), and general data on failed institutes were utilized to form this report. The report covers the working group's findings on institute mission, structure, director, board of directors/advisors, the working environment, research arrangements, intellectual property rights, business management, institute funding, and metrics.

  2. Lessons from history: morbidity of cold injury in the Royal Marines during the Falklands Conflict of 1982.

    PubMed

    Golden, Francis St Clair; Francis, Thomas James Roose; Gallimore, Deborah; Pethybridge, Roger

    2013-08-08

    Environmental conditions in the Falklands Conflict of 1982 favoured the genesis of cold injuries. Immediately, post-war, cold injury morbidity and its contributory factors were assessed, in the personnel of UK 3 Commando Brigade (3 Cdo Bde). A questionnaire survey of the 3,006 members of 3 Cdo Bde who landed on the islands was conducted within 6-10 weeks of the end of hostilities. Questions included those relating to features of cold injury, body morphology, age, symptoms experienced, past medical history and other possible contributory causes. Additionally, the unit medical team conducted a cursory examination. Data were sent to the Royal Navy Institute of Naval Medicine (INM), where the degree of likely cold injury was broadly classified ('asymptomatic' 'mild', 'moderate' or 'severe'). A sample (total 109) was then selected at random from each category and subsequently examined and tested at the INM (nerve conduction, photoplethysmography and thermography testing). Forty-seven non-cold exposed sailors acted as a control group. These contemporaneous records have now been identified and interrogated. Some 2,354 (78%) completed questionnaires were returned, revealing that 1,505 (64%) had experienced symptoms of non-freezing cold injury. The morbidity in the infantry units was significantly greater than that in the support troops (1,051 (76%) vs 454 (46%), p < 0.05). No evidence was found to support an influence of a number of factors, commonly believed to have an aetiological role in the production of cold injury. Whilst there was no significant relationship between past history and cold injury morbidity in the brigade as a whole, or within the infantry units alone, an association was identified in the collective infantry units (73%) and the support/headquarter units (59%) (p < 0.05).In comparison with uninjured sailors who acted as controls (n = 47), nerve conduction was impaired in 35% of those screened some months after returning to the UK, while the

  3. Netherlands to Aid Central, Eastern Europe in Halting Pollution Effects.

    ERIC Educational Resources Information Center

    O'Sullivan, Dermot A.

    1991-01-01

    Discussed are efforts originating in the Netherlands to assist the Soviet Union and Eastern European counties to form and carry out significant air and water pollution improvement policies. Examples of proposals and programs being formed are described. (CW)

  4. [Population forecasts for the Netherlands, 1986-2035].

    PubMed

    Cruijsen, H

    1987-02-01

    Results of the 1986 official population forecasts for the Netherlands are presented, and the assumptions made in their preparation are described. Comparisons are made with forecasts for 1985. Three alternative variations of the forecasts are included. (SUMMARY IN ENG)

  5. Dutch perspectives on palliative care in the Netherlands.

    PubMed

    Cohen-Almagor, Raphael

    2002-01-01

    This study reports data gathered via extensive interviews with some of the leading authorities on the euthanasia policy that were conducted in the Netherlands. They were asked: It has been argued that the policy and practice of euthanasia in the Netherlands is the result of undeveloped palliative care. What do you think? I also mentioned the fact that there are only a few hospices in the Netherlands. The responses were different and contradictory. Many interviewees agreed with the statement. Almost all of those agreeing with it said that only during the late 1990s were people beginning to admit that there was a need to improve palliative care. Some interviewees insisted that doctors first need to explore other options for helping the patient prior to choosing the course of euthanasia. Other interviewees thought that palliative care is well developed in the Netherlands and that euthanasia has actually paved the way for calling more attention to palliative care.

  6. Netherlands to Aid Central, Eastern Europe in Halting Pollution Effects.

    ERIC Educational Resources Information Center

    O'Sullivan, Dermot A.

    1991-01-01

    Discussed are efforts originating in the Netherlands to assist the Soviet Union and Eastern European counties to form and carry out significant air and water pollution improvement policies. Examples of proposals and programs being formed are described. (CW)

  7. Euthanasia and the legal situation in The Netherlands.

    PubMed

    deHaas, G

    In The Netherlands a doctor may, under certain circumstances, avoid prosecution if he or she helps a patient to die who has persistently requested euthanasia. This paper describes the current legal situation.

  8. Voluntary euthanasia under control? Further empirical evidence from The Netherlands.

    PubMed Central

    Jochemsen, H; Keown, J

    1999-01-01

    Nineteen ninety-six saw the publication of a major Dutch survey into euthanasia in the Netherlands. This paper outlines the main statistical findings of this survey and considers whether it shows that voluntary euthanasia is under effective control in the Netherlands. The paper concludes that although there has been some improvement in compliance with procedural requirements, the practice of voluntary euthanasia remains beyond effective control. PMID:10070633

  9. Widespread Usutu virus outbreak in birds in the Netherlands, 2016.

    PubMed

    Rijks, J M; Kik, M L; Slaterus, R; Foppen, Rpb; Stroo, A; IJzer, J; Stahl, J; Gröne, A; Koopmans, Mgp; van der Jeugd, H P; Reusken, Cbem

    2016-11-10

    We report a widespread Usutu virus outbreak in birds in the Netherlands. Viral presence had been detected through targeted surveillance as early as April 2016 and increased mortality in common blackbirds and captive great grey owls was noticed from August 2016 onwards. Usutu virus infection was confirmed by post-mortem examination and RT-PCR. Extensive Usutu virus activity in the Netherlands in 2016 underlines the need to monitor mosquito activity and mosquito-borne infections in 2017 and beyond.

  10. Evaluation of the Netherlands' International Test Facility for Smart Grids

    SciTech Connect

    Palmintier, Bryan; Pratt, Annabelle

    2015-06-01

    The Netherlands Enterprise Agency (Rijksdienst voor Ondernemend Nederland, or RVO) engaged the U.S. National Renewable Energy Laboratory (NREL) for two primary purposes: to evaluate the International Test Facility for Smart Grids (ITF) sponsored by RVO and to learn best practices for integrated test facilities from NREL's Energy Systems Integration Facility (ESIF). This report covers the ITF evaluation and is largely based on a one-week visit to the Netherlands in November 2014.

  11. Widespread Usutu virus outbreak in birds in the Netherlands, 2016

    PubMed Central

    Rijks, JM; Kik, ML; Slaterus, R; Foppen, RPB; Stroo, A; IJzer, J; Stahl, J; Gröne, A; Koopmans, MGP; van der Jeugd, HP; Reusken, CBEM

    2016-01-01

    We report a widespread Usutu virus outbreak in birds in the Netherlands. Viral presence had been detected through targeted surveillance as early as April 2016 and increased mortality in common blackbirds and captive great grey owls was noticed from August 2016 onwards. Usutu virus infection was confirmed by post-mortem examination and RT-PCR. Extensive Usutu virus activity in the Netherlands in 2016 underlines the need to monitor mosquito activity and mosquito-borne infections in 2017 and beyond. PMID:27918257

  12. Simultaneous determination of trace migration of phthalate esters in honey and royal jelly by GC-MS.

    PubMed

    Zhou, Jinhui; Qi, Yitao; Wu, Hongmei; Diao, Qingyun; Tian, Feifei; Li, Yi

    2014-03-01

    A simple, rapid, and reliable liquid-liquid extraction coupled to GC-MS method was developed and validated for the quantification of 22 phthalate esters (PAEs) in honey and royal jelly. Instrument parameters for GC-MS were tested to obtain the satisfactory separation between 22 PAEs with high sensitivity. The extraction procedure was optimized in order to achieve the best recovery. The following criteria were used to validate the developed method: linearity, LOD, lower LOQ, precision, accuracy, matrix effect and carry-over. Correlation coefficients were >0.999 by applying the linear regression model based on the least-squares method with a weighting factor (1/x). The intra- and interday precision were within 12.7% in terms of RSD, and the accuracy was within -11.8% in terms of relative error. The mean extraction recoveries ranged between 80.1 and 110.9% for honey and royal jelly. No significant matrix effect and carry-over for PAEs were observed for the analysis of honey and royal jelly samples. A total of 20 real samples were analyzed for a mini-survey using the developed method. Seven PAEs in honey samples and five PAEs in royal jelly samples were found, indicating potential contamination with several PAEs.

  13. Flying Start: Educational and Social Factors in the Recruitment of Pilots of the Royal Air Force in the Interwar Years.

    ERIC Educational Resources Information Center

    Mansell, Tony

    1997-01-01

    Describes the various means of entry into the Royal Air Force (RAF) during the interwar years. Although originally limited to recruits with social connections, the program changed under pressure of rearmament and impending war with Germany. By the late 1930s, occupational aptitude superseded social standing as an admission requirement. (MJP)

  14. Storage temperature and 1-MCP treatment affect storage disorders and physiological attributes of ‘Royal Gala’ apples

    USDA-ARS?s Scientific Manuscript database

    Royal Gala’ apples [Malus domestica (Borkh.) Mansf.] can develop postharvest disorders such as flesh browning, senescent breakdown, peeling, cracking, or shriveling during and after cold storage. The objective of this study was to examine the effects of storage temperature and a range of 1-methylc...

  15. Implementation of an Open Source Library Management System: Experiences with Koha 3.0 at the Royal London Homoeopathic Hospital

    ERIC Educational Resources Information Center

    Bissels, Gerhard

    2008-01-01

    Purpose: The purpose of this paper is to describe the selection process and criteria that led to the implementation of the Koha 3.0 library management system (LMS) at the Complementary and Alternative Medicine Library and Information Service (CAMLIS), Royal London Homoeopathic Hospital. Design/methodology/approach: The paper is a report based on…

  16. Implementation of an Open Source Library Management System: Experiences with Koha 3.0 at the Royal London Homoeopathic Hospital

    ERIC Educational Resources Information Center

    Bissels, Gerhard

    2008-01-01

    Purpose: The purpose of this paper is to describe the selection process and criteria that led to the implementation of the Koha 3.0 library management system (LMS) at the Complementary and Alternative Medicine Library and Information Service (CAMLIS), Royal London Homoeopathic Hospital. Design/methodology/approach: The paper is a report based on…

  17. Two Years on: Koha 3.0 in Use at the CAMLIS Library, Royal London Homoeopathic Hospital

    ERIC Educational Resources Information Center

    Bissels, Gerhard; Chandler, Andrea

    2010-01-01

    Purpose: The purpose of this paper is to describe the further development of the Koha 3.0 library management system (LMS) and the involvement of external software consultants at the Complementary and Alternative Medicine Library and Information Service (CAMLIS), Royal London Homoeopathic Hospital. Design/methodology/approach: The paper takes the…

  18. Children at Risk in School: Proceedings of a Day Conference at the Royal Commonwealth Society on Wednesday, February 5, 1975.

    ERIC Educational Resources Information Center

    National Association for the Care and Resettlement of Offenders, (England).

    This booklet consists of ther proceedings of a day conference at the Royal Commonwealth Society to explore the subject of crime prevention in relation to children in school. It is divided into several sections which speak to the following: (1) report summary of comments made by the various participants; (2) how teachers can help to combat crime;…

  19. Present Practices and Background to Teaching and Learning at the Royal University of Bhutan (RUB): A Pilot Study

    ERIC Educational Resources Information Center

    Gyamtso, Deki; Maxwell, T. W.

    2012-01-01

    In Bhutan relatively few studies at the higher education level have been done and fewer still reported in international journals. This pilot study highlights the present practices and culture of teaching and learning at one of the teacher education colleges of the Royal University of Bhutan (RUB). It looks broadly across the issues of…

  20. Two Years on: Koha 3.0 in Use at the CAMLIS Library, Royal London Homoeopathic Hospital

    ERIC Educational Resources Information Center

    Bissels, Gerhard; Chandler, Andrea

    2010-01-01

    Purpose: The purpose of this paper is to describe the further development of the Koha 3.0 library management system (LMS) and the involvement of external software consultants at the Complementary and Alternative Medicine Library and Information Service (CAMLIS), Royal London Homoeopathic Hospital. Design/methodology/approach: The paper takes the…