Smoking cessation interventions following acute coronary syndrome: a missed opportunity?

PubMed

Boggon, Rachael; Timmis, Adam; Hemingway, Harry; Raju, Sunil; Malvestiti, Franco Mondello; Van Staa, Tjeerd P

2014-06-01

It is recommended that general practitioners (GPs) offer cessation advice and pharmacological interventions to smokers with acute coronary syndrome (ACS). The study objective was to describe the extent to which this is done, and to describe outcomes by smoking status. Patients aged 30+ hospitalised for troponin-positive ACS from 2002 to 2009, discharged home alive, were identified in the Myocardial Ischaemia National Audit Project registry. Patient data were linked to the General Practice Research Database, Hospital Episode Statistics, and Office of National Statistics mortality data, enabling a unique perspective of longitudinal smoking data. Patients who smoked prior to the hospitalisation had GP interventions and quitting status established in the 3 months following discharge, and were followed up for major clinical outcomes. The outcomes evaluated included death, repeat ACS, stroke, heart failure, and major adverse cardiac events (MACE). Of the 4834 patients included, 965 (20%) were smokers at the time of their ACS. After the ACS event, only 225 (24%) received any GP smoking intervention within 3 months, with 82 (9%) receiving advice only, and 143 (15%) receiving a pharmacological intervention. Patients who quit (320; 33%) were at a decreased risk of mortality (relative risk (RR) 0.49; 95% confidence interval (CI) 0.35-0.69) and MACE (RR 0.61; 0.46-0.80) compared with patients who did not. Whilst a high proportion of patients with ACS are smokers, there is a low level of GP cessation intervention following hospital discharge. This missed opportunity of patient care is important given the decreased risk of mortality and MACE found amongst those who quit. © The European Society of Cardiology 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Smoking cessation interventions following acute coronary syndrome: a missed opportunity?

PubMed Central

Boggon, Rachael; Timmis, Adam; Hemingway, Harry; Raju, Sunil; Malvestiti, Franco Mondello; Van Staa, Tjeerd P

2015-01-01

Background It is recommended that general practitioners (GPs) offer cessation advice and pharmacological interventions to smokers with acute coronary syndrome (ACS). The study objective was to describe the extent to which this is done, and to describe outcomes by smoking status. Design Patients aged 30+ hospitalised for troponin-positive ACS from 2002 to 2009, discharged home alive, were identified in the Myocardial Ischaemia National Audit Project registry. Patient data were linked to the General Practice Research Database, Hospital Episode Statistics, and Office of National Statistics mortality data, enabling a unique perspective of longitudinal smoking data. Patients who smoked prior to the hospitalisation had GP interventions and quitting status established in the 3 months following discharge, and were followed up for major clinical outcomes. Methods The outcomes evaluated included death, repeat ACS, stroke, heart failure, and major adverse cardiac events (MACE). Results Of the 4834 patients included, 965 (20%) were smokers at the time of their ACS. After the ACS event, only 225 (24%) received any GP smoking intervention within 3 months, with 82 (9%) receiving advice only, and 143 (15%) receiving a pharmacological intervention. Patients who quit (320; 33%) were at a decreased risk of mortality (relative risk (RR) 0.49; 95% confidence interval (CI) 0.35–0.69) and MACE (RR 0.61; 0.46–0.80) compared with patients who did not. Conclusions Whilst a high proportion of patients with ACS are smokers, there is a low level of GP cessation intervention following hospital discharge. This missed opportunity of patient care is important given the decreased risk of mortality and MACE found amongst those who quit. PMID:22952289

Workload and non-contact injury incidence in elite football players competing in European leagues.

PubMed

Delecroix, Barthelemy; McCall, Alan; Dawson, Brian; Berthoin, Serge; Dupont, Gregory

2018-06-02

The aim of this study was to analyse the relationship between absolute and acute:chronic workload ratios and non-contact injury incidence in professional football players and to assess their predictive ability. Elite football players (n = 130) from five teams competing in European domestic and confederation level competitions were followed during one full competitive season. Non-contact injuries were recorded and using session rate of perceived exertion (s-RPE) internal absolute workload and acute:chronic (A:C) workload ratios (4-weeks, 3-weeks, 2-weeks and week-to-week) were calculated using a rolling days method. The relative risk (RR) of non-contact injury was increased (RR = 1.59, CI95%: 1.18-2.15) when a cumulative 4-week absolute workload was greater than 10629 arbitrary units (AU) in comparison with a workload between 3745 and 10628 AU. When the 3-week absolute workload was more than 8319 AU versus between 2822 and 8318 AU injury risk was also increased (RR= 1.46, CI95% 1.08-1.98). Injury incidence was higher when the 4-week A:C ratio was <0.85 versus >0.85 (RR = 1.31, CI95%: 1.02-1.70) and with a 3-week A:C ratio >1.30 versus <1.30 (RR = 1.37, CI95%: 1.05-1.77). Importantly, none of the A:C workload combinations showed high sensitivity or specificity. In elite European footballers, using internal workload (sRPE) revealed that cumulative workloads over 3 and 4 weeks were associated with injury incidence. Additionally, A:C workloads, using combinations of 2, 3 and 4 weeks as the C workloads were also associated with increased injury risk. No A:C workload combination was appropriate to predict injury.

Gauss Modular-Arithmetic Congruence = Signal X Noise PRODUCT: Clock-model Archimedes HYPERBOLICITY Centrality INEVITABILITY: Definition: Complexity= UTTER-SIMPLICITY: Natural-Philosophy UNITY SIMPLICITY Redux!!!

NASA Astrophysics Data System (ADS)

Kummer, E. E.; Siegel, Edward Carl-Ludwig

2011-03-01

Clock-model Archimedes [http://linkage.rockeller.edu/ wli/moved.8.04/ 1fnoise/ index. ru.html] HYPERBOLICITY inevitability throughout physics/pure-maths: Newton-law F=ma, Heisenberg and classical uncertainty-principle=Parseval/Plancherel-theorems causes FUZZYICS definition: (so miscalled) "complexity" = UTTER-SIMPLICITY!!! Watkins[www.secamlocal.ex.ac.uk/people/staff/mrwatkin/]-Hubbard[World According to Wavelets (96)-p.14!]-Franklin[1795]-Fourier[1795;1822]-Brillouin[1922] dual/inverse-space(k,w) analysis key to Fourier-unification in Archimedes hyperbolicity inevitability progress up Siegel cognition hierarchy-of-thinking (HoT): data-info.-know.-understand.-meaning-...-unity-simplicity = FUZZYICS!!! Frohlich-Mossbauer-Goldanskii-del Guidice [Nucl.Phys.B:251,375(85);275,185 (86)]-Young [arXiv-0705.4678y2, (5/31/07] theory of health/life=aqueous-electret/ ferroelectric protoplasm BEC = Archimedes-Siegel [Schrodinger Cent.Symp.(87); Symp.Fractals, MRS Fall Mtg.(89)-5-pprs] 1/w-"noise" Zipf-law power-spectrum hyperbolicity INEVITABILITY= Chi; Dirac delta-function limit w=0 concentration= BEC = Chi-Quong.

Differences of Articulation Rate and Utterance Length in Fluent and Disfluent Utterances of Preschool Children Who Stutter

PubMed Central

Chon, HeeCheong; Sawyer, Jean; Ambrose, Nicoline G.

2014-01-01

Purpose The purpose of this study was to investigate characteristics of four types of utterances in preschool children who stutter: perceptually fluent, containing normal disfluencies (OD utterance), containing stuttering-like disfluencies (SLD utterance), and containing both normal and stuttering-like disfluencies (SLD+OD utterance). Articulation rate and length of utterance were measured to seek the differences. Because articulation rate may reflect temporal aspects of speech motor control, it was predicted that the articulation rate would be different between perceptually fluent utterances and utterances containing disfluencies. The length of utterance was also expected to show different patterns. Method Participants were 14 preschool children who stutter. Disfluencies were identified from their spontaneous speech samples, and articulation rate in syllables per second and utterance length in syllables were measured for the four types of utterances. Results and discussion There was no significant difference in articulation rate between each type of utterance. Significantly longer utterances were found only in SLD+OD utterances compared to fluent utterances, suggesting that utterance length may be related to efforts in executing motor as well as linguistic planning. The SLD utterance revealed a significant negative correlation in that longer utterances tended to be slower in articulation rates. Longer utterances may place more demand on speech motor control due to more linguistic and/or grammatical features, resulting in stuttering-like disfluencies and a decreased rate. PMID:22995336

Risk Factors for Blood Transfusion With Primary Posterior Lumbar Fusion.

PubMed

Basques, Bryce A; Anandasivam, Nidharshan S; Webb, Matthew L; Samuel, Andre M; Lukasiewicz, Adam M; Bohl, Daniel D; Grauer, Jonathan N

2015-11-01

Retrospective cohort study. To identify factors associated with blood transfusion for primary posterior lumbar fusion surgery, and to identify associations between blood transfusion and other postoperative complications. Blood transfusion is a relatively common occurrence for patients undergoing primary posterior lumbar fusion. There is limited information available describing which patients are at increased risk for blood transfusion, and the relationship between blood transfusion and short-term postoperative outcomes is poorly characterized. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients undergoing primary posterior lumbar fusion from 2011 to 2013. Multivariate analysis was used to find associations between patient characteristics and blood transfusion, along with associations between blood transfusion and postoperative outcomes. Out of 4223 patients, 704 (16.7%) had a blood transfusion. Age 60 to 69 (relative risk [RR] 1.6), age greater than equal to 70 (RR 1.7), American Society of Anesthesiologists class greater than equal to 3 (RR 1.1), female sex (RR 1.1), pulmonary disease (RR 1.2), preoperative hematocrit less than 36.0 (RR 2.0), operative time greater than equal to 310 minutes (RR 2.9), 2 levels (RR 1.6), and 3 or more levels (RR 2.1) were independently associated with blood transfusion. Interbody fusion (RR 0.9) was associated with decreased rates of blood transfusion. Receiving a blood transfusion was significantly associated with any complication (RR 1.7), sepsis (RR 2.6), return to the operating room (RR 1.7), deep surgical site infection (RR 2.6), and pulmonary embolism (RR 5.1). Blood transfusion was also associated with an increase in postoperative length of stay of 1.4 days (P < 0.001). 1 in 6 patients received a blood transfusion while undergoing primary posterior lumbar fusion, and risk factors for these occurrences were characterized. Strategies to minimize blood loss might be considered in these patients to avoid the associated complications. 3.

Change in health behaviours following acute coronary syndrome: Arab-Jewish differences.

PubMed

Reges, Orna; Vilchinsky, Noa; Leibowitz, Morton; Khaskia, Abdulrahem; Mosseri, Morris; Kark, Jeremy D

2015-04-01

Health-promoting behaviours after acute coronary syndrome (ACS) are effective in preventing recurrence. Ethnicity impacts on such behaviours. We assessed the independent association of Arab vs. Jewish ethnicity with persistence of smoking and physical inactivity 6 months after ACS in central Israel. Prospective cohort study. During their admission for ACS and subsequently 6 months later, 420 patients were interviewed about their smoking and exercise habits. The association of ethnicity with health-promoting behaviours was assessed by logistic regression adjusting for socio-demographic and clinical covariates. Smoking prevalence and physical inactivity were substantially higher among Arab patients than Jewish patients at admission (gender-adjusted prevalence rate ratio (RR) 2.25, 95% CI 1.80-2.81, p < 0.01 and RR 1.46, 95% CI 1.28-1.67, p < 0.001, respectively). The relative differences increased at 6 months (RR 2.94, 95% CI 2.13-4.07, p < 0.001 and RR 3.00, 95% CI 2.24-4.04, p < 0.001, respectively). Excess persistent smoking at 6 months among Arab vs. Jewish patients who were smokers at admission (adjusted OR 2.05, 95% CI 1.00-4.20, p = 0.049) was largely mediated through the 3.5-fold higher participation of Jewish patients in cardiac prevention and rehabilitation program (CPRP) (OR adjusted also for CPRP 1.31, 95% CI 0.59-2.93, p = 0.51). Greater persistent sedentary behaviour at 6 months among nonexercisers at admission among Arab patients (adjusted OR 3.68, 95% CI 1.93-7.02, p < 0.001) was partly mediated through attendance of CPRP (OR adjusted also for CPRP 2.38, 95% CI 1.19-4.76, p = 0.014). Culturally sensitive programmes need to be developed to enhance CPRP participation and favourable health-promoting changes among Arab patients. A comprehensive understanding of the determinants of the Arab-Jewish differences in efficacious health-promoting behaviours is crucial to inform appropriate ethnic-specific health-promoting strategies. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Statins for acute coronary syndrome.

PubMed

Vale, Noah; Nordmann, Alain J; Schwartz, Gregory G; de Lemos, James; Colivicchi, Furio; den Hartog, Frank; Ostadal, Petr; Macin, Stella M; Liem, Anho H; Mills, Edward J; Bhatnagar, Neera; Bucher, Heiner C; Briel, Matthias

2014-09-01

The early period following the onset of acute coronary syndrome (ACS) represents a critical stage of coronary heart disease, with a high risk of recurrent events and deaths. The short-term effects of early treatment with statins on patient-relevant outcomes in patients suffering from ACS are unclear. This is an update of a review previously published in 2011. To assess the effects, both harms and benefits, of early administered statins in patients with ACS, in terms of mortality and cardiovascular events. We updated the searches of CENTRAL (2013, Issue 3), MEDLINE (Ovid) (1946 to April Week 1 2013), EMBASE (Ovid) (1947 to 2013 Week 14), and CINAHL (EBSCO) (1938 to 2013) on 12 April 2013. We applied no language restrictions. We supplemented the search by contacting experts in the field, by reviewing the reference lists of reviews and editorials on the topic, and by searching trial registries. Randomized controlled trials (RCTs) comparing statins with placebo or usual care, with initiation of statin therapy within 14 days following the onset of ACS, follow-up of at least 30 days, and reporting at least one clinical outcome. Two authors independently assessed risk of bias and extracted data. We calculated risk ratios (RRs) for all outcomes in the treatment and control groups and pooled data using random-effects models. Eighteen studies (14,303 patients) compared early statin treatment versus placebo or no treatment in patients with ACS. The new search did not identify any new studies for inclusion. There were some concerns about risk of bias and imprecision of summary estimates. Based on moderate quality evidence, early statin therapy did not decrease the combined primary outcome of death, non-fatal myocardial infarction, and stroke at one month (risk ratio (RR) 0.93, 95% confidence interval (CI) 0.80 to 1.08) or four months (RR 0.93, 95% CI 0.81 to 1.06) of follow-up when compared to placebo or no treatment. There were no statistically significant risk reductions from statins for total death, total myocardial infarction, total stroke, cardiovascular death, revascularization procedures, and acute heart failure at one month or at four months, although there were favorable trends related to statin use for each of these endpoints. Moderate quality evidence suggests that the incidence of unstable angina was significantly reduced at four months following ACS (RR 0.76, 95% CI 0.59 to 0.96). There were nine individuals with myopathy (elevated creatinine kinase levels more than 10 times the upper limit of normal) in statin-treated patients (0.13%) versus one (0.015%) in the control groups. Serious muscle toxicity was mostly limited to patients treated with simvastatin 80 mg. Based on moderate quality evidence, due to concerns about risk of bias and imprecision, initiation of statin therapy within 14 days following ACS does not reduce death, myocardial infarction, or stroke up to four months, but reduces the occurrence of unstable angina at four months following ACS. Serious side effects were rare.

Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis.

PubMed

Abrahan, Lauro L; Ramos, John Daniel A; Cunanan, Elleen L; Tiongson, Marc Denver A; Punzalan, Felix Eduardo R

2018-06-01

Red cell distribution width (RDW), a routine component of the complete blood count (CBC), measures variation in the size of circulating erythrocytes. It has been associated with several clinical outcomes in cardiovascular disease. We sought to strengthen the association between RDW and mortality in patients admitted for acute coronary syndrome (ACS) by pooling together data from available studies. Studies that fulfilled the following were identified for analysis: 1) observational; 2) included patients admitted for ACS; 3) reported data on all-cause or cardiovascular (CV) mortality in association with a low or high RDW; and 4) used logistic regression analysis to control for confounders. Using MEDLINE, Clinical Key, ScienceDirect, Scopus, and Cochrane Central Register of Controlled Trials databases, a search for eligible studies was conducted until January 9, 2017. The quality of each study was evaluated using the Newcastle-Ottawa Quality Assessment Scale. Our primary outcome of interest was all-cause or CV mortality. We also investigated the impact of RDW on major adverse cardiovascular events (MACEs) for the studies that reported these outcomes. Review Manager (RevMan) 5.3 was utilized to perform Mantel-Haenzel analysis of random effects and compute for relative risk. We identified 13 trials involving 10,410 patients, showing that in ACS, a low RDW is associated with a statistically significant lower all-cause or CV mortality (RR 0.35, (95% CI 0.30 to 0.40), P < 0.00001, I 2 = 53%), a finding that was consistent both in the short- and long-term. A low RDW is also associated with lower risk for MACEs after an ACS (RR 0.56, (95% CI 0.51 to 0.61), P < 0.00001, I 2 = 91%). A low RDW during an ACS is associated with lower all-cause or CV mortality and lower risk of subsequent MACEs, providing us with a convenient and inexpensive risk stratification tool in ACS patients.

Investigate feasibility of using ground penetrating radar in QC/QA of rubblization projects : executive summary report.

DOT National Transportation Integrated Search

2011-07-01

Rubblization and Roll (R/R) is an activity routinely practiced by the state DOTs for the rehabilitation of in-service composite pavements. The AC layer is milled and the exposed concrete pavement is broken (rubblized) into small fragments using heavy...

Thermal modification of activated carbon surface chemistry improves its capacity as redox mediator for azo dye reduction.

PubMed

Pereira, L; Pereira, R; Pereira, M F R; van der Zee, F P; Cervantes, F J; Alves, M M

2010-11-15

The surface chemistry of a commercial AC (AC(0)) was selectively modified, without changing significantly its textural properties, by chemical oxidation with HNO(3) (AC(HNO3)) and O(2) (AC(O2)), and thermal treatments under H(2) (AC(H2)) or N(2) (AC(N2)) flow. The effect of modified AC on anaerobic chemical dye reduction was assayed with sulphide at different pH values 5, 7 and 9. Four dyes were tested: Acid Orange 7, Reactive Red 2, Mordant Yellow 10 and Direct Blue 71. Batch experiments with low amounts of AC (0.1 g L(-1)) demonstrated an increase of the first-order reduction rate constants, up to 9-fold, as compared with assays without AC. Optimum rates were obtained at pH 5 except for MY10, higher at pH 7. In general, rates increased with increasing the pH of point zero charge (pH(pzc)), following the trend AC(HNO3) < AC(O2) < AC(0) < AC(N2) < AC(H2). The highest reduction rate was obtained for MY10 with AC(H2) at pH 7, which corresponded to the double, as compared with non-modified AC. In a biological system using granular biomass, AC(H2) also duplicated and increase 4.5-fold the decolourisation rates of MY10 and RR2, respectively. In this last experiment, reaction rate was independent of AC concentration in the tested range 0.1-0.6 g L(-1). Copyright © 2010 Elsevier B.V. All rights reserved.

Differences of Articulation Rate and Utterance Length in Fluent and Disfluent Utterances of Preschool Children Who Stutter

ERIC Educational Resources Information Center

Chon, HeeCheong; Sawyer, Jean; Ambrose, Nicoline G.

2012-01-01

Purpose: The purpose of this study was to investigate characteristics of four types of utterances in preschool children who stutter: perceptually fluent, containing normal disfluencies (OD utterance), containing stuttering-like disfluencies (SLD utterance), and containing both normal and stuttering-like disfluencies (SLD+OD utterance).…

Effects of prosodic boundary on /aC/ sequences: articulatory results

NASA Astrophysics Data System (ADS)

Tabain, Marija

2003-05-01

This study presents EMA (electromagnetic articulography) data on articulation of the vowel /a/ at different prosodic boundaries in French. Three speakers of metropolitan French produced utterances containing the vowel /a/, preceded by /tee/ and followed by one of six consonants /bee dee gee eff ess sh/ (three stops and three fricatives), with different prosodic boundaries intervening between the /a/ and the six different consonants. The prosodic boundaries investigated are the Utterance, the Intonational phrase, the Accentual phrase, and the Word. Data for the Tongue Tip, Tongue Body, and Jaw are presented. The articulatory data presented here were recorded at the same time as the acoustic data presented in Tabain [J. Acoust. Soc. Am. 113, 516-531 (2003)]. Analyses show that there is a strong effect on peak displacement of the vowel according to the prosodic hierarchy, with the stronger prosodic boundaries inducing a much lower Tongue Body and Jaw position than the weaker prosodic boundaries. Durations of both the opening movement into and the closing movement out of the vowel are also affected. Peak velocity of the articulatory movements is also examined, and, contrary to results for phrase-final lengthening, it is found that peak velocity of the opening movement into the vowel tends to increase with the higher prosodic boundaries, together with the increased magnitude of the movement between the consonant and the vowel. Results for the closing movement out of the vowel and into the consonant are not so clear. Since one speaker shows evidence of utterance-level articulatory declension, it is suggested that the competing constraints of articulatory declension and prosodic effects might explain some previous results on phrase-final lengthening.

Changes in pupil diameter are correlated with the occurrence of pareidolias in patients with dementia with Lewy bodies.

PubMed

Suzuki, Yumi; Hirayama, Kazumi; Shimomura, Tatsuo; Uchiyama, Makoto; Fujii, Hiromi; Mori, Etsuro; Nishio, Yoshiyuki; Iizuka, Osamu; Inoue, Ryusuke; Otsuki, Mika; Sakai, Shinya

2017-03-01

Pareidolias are visual illusions of meaningful objects, such as faces and animals, that arise from ambiguous forms embedded in visual scenes. Pareidolias and visual hallucinations have been suggested to have a common underlying neural mechanism in patients with dementia with Lewy bodies (DLB). The aim of the present study was to find an externally observable physiological indicator of pareidolias. Using a pareidolia test developed by Uchiyama and colleagues, we evoked pareidolias in patients with DLB and recorded the resultant changes in the diameters of their pupil. The time frequencies of changes in pupil diameters preceding pareidolic utterances and correct utterances by the patients, as well as correct utterances by healthy control participants, were analyzed by a fast Fourier transform program. The power at time frequencies of 0-0.46 Hz was found to be greatest preceding pareidolic utterances in patients with DLB, followed by that preceding correct utterances in control participants, followed by that preceding correct utterances in patients with DLB. When the changes in power preceding the utterance were greater than the median value of correct utterances by the control group, the frequency of pareidolic utterances was significantly greater than that of correct utterances and when the changes were the same as or lower than the median value, the frequency of correct utterances was significantly greater than that of pareidolic utterances. Greater changes in power preceding the utterance at time frequencies of 0-0.46 Hz may thus be an externally observable physiological indicator of the occurrence of pareidolias.

Changes in pupil diameter are correlated with the occurrence of pareidolias in patients with dementia with Lewy bodies

PubMed Central

Suzuki, Yumi; Hirayama, Kazumi; Shimomura, Tatsuo; Uchiyama, Makoto; Fujii, Hiromi; Mori, Etsuro; Nishio, Yoshiyuki; Iizuka, Osamu; Inoue, Ryusuke; Otsuki, Mika

2017-01-01

Pareidolias are visual illusions of meaningful objects, such as faces and animals, that arise from ambiguous forms embedded in visual scenes. Pareidolias and visual hallucinations have been suggested to have a common underlying neural mechanism in patients with dementia with Lewy bodies (DLB). The aim of the present study was to find an externally observable physiological indicator of pareidolias. Using a pareidolia test developed by Uchiyama and colleagues, we evoked pareidolias in patients with DLB and recorded the resultant changes in the diameters of their pupil. The time frequencies of changes in pupil diameters preceding pareidolic utterances and correct utterances by the patients, as well as correct utterances by healthy control participants, were analyzed by a fast Fourier transform program. The power at time frequencies of 0–0.46 Hz was found to be greatest preceding pareidolic utterances in patients with DLB, followed by that preceding correct utterances in control participants, followed by that preceding correct utterances in patients with DLB. When the changes in power preceding the utterance were greater than the median value of correct utterances by the control group, the frequency of pareidolic utterances was significantly greater than that of correct utterances and when the changes were the same as or lower than the median value, the frequency of correct utterances was significantly greater than that of pareidolic utterances. Greater changes in power preceding the utterance at time frequencies of 0–0.46 Hz may thus be an externally observable physiological indicator of the occurrence of pareidolias. PMID:28134631

Association between community health center and rural health clinic presence and county-level hospitalization rates for ambulatory care sensitive conditions: an analysis across eight US states.

PubMed

Probst, Janice C; Laditka, James N; Laditka, Sarah B

2009-07-31

Federally qualified community health centers (CHCs) and rural health clinics (RHCs) are intended to provide access to care for vulnerable populations. While some research has explored the effects of CHCs on population health, little information exists regarding RHC effects. We sought to clarify the contribution that CHCs and RHCs may make to the accessibility of primary health care, as measured by county-level rates of hospitalization for ambulatory care sensitive (ACS) conditions. We conducted an ecologic analysis of the relationship between facility presence and county-level hospitalization rates, using 2002 discharge data from eight states within the US (579 counties). Counties were categorized by facility availability: CHC(s) only, RHC(s) only, both (CHC and RHC), and neither. US Agency for Healthcare Research and Quality definitions were used to identify ACS diagnoses. Discharge rates were based on the individual's county of residence and were obtained by dividing ACS hospitalizations by the relevant county population. We calculated ACS rates separately for children, working age adults, and older individuals, and for uninsured children and working age adults. To ensure stable rates, we excluded counties having fewer than 1,000 residents in the child or working age adult categories, or 500 residents among those 65 and older. Multivariate Poisson analysis was used to calculate adjusted rate ratios. Among working age adults, rate ratio (RR) comparing ACS hospitalization rates for CHC-only counties to those of counties with neither facility was 0.86 (95% Confidence Interval, CI, 0.78-0.95). Among older adults, the rate ratio for CHC-only counties compared to counties with neither facility was 0.84 (CI 0.81-0.87); for counties with both CHC and RHC present, the RR was 0.88 (CI 0.84-0.92). No CHC/RHC effects were found for children. No effects were found on estimated hospitalization rates among uninsured populations. Our results suggest that CHCs and RHCs may play a useful role in providing access to primary health care. Their presence in a county may help to limit the county's rate of hospitalization for ACS diagnoses, particularly among older people.

Successive Single-Word Utterances and Use of Conversational Input: A Pre-Syntactic Route to Multiword Utterances

ERIC Educational Resources Information Center

Herr-Israel, Ellen; McCune, Lorraine

2011-01-01

In the period between sole use of single words and majority use of multiword utterances, children draw from their existing productive capability and conversational input to facilitate the eventual outcome of majority use of multiword utterances. During this period, children use word combinations that are not yet mature multiword utterances, termed…

The Effects of Two Levels of Linguistic Constraint on Echolalia and Generative Language Production in Children with Autism.

ERIC Educational Resources Information Center

Rydell, Patrick J.; Mirenda, Pat

1991-01-01

This study of 3 boys (ages 5-6) with autism found that adult high-constraint antecedent utterances elicited more verbal utterances in general, including subjects' echolalia; adult low-constraint utterances elicited more subject high-constraint utterances; and the degree of adult-utterance constraint did not influence the mean lengths of subjects'…

Early syntactic creativity: a usage-based approach.

PubMed

Lieven, Elena; Behrens, Heike; Speares, Jennifer; Tomasello, Michael

2003-05-01

The aim of the current study was to determine the degree to which a sample of one child's creative utterances related to utterances that the child previously produced. The utterances to be accounted for were all of the intelligible, multi-word utterances produced by the child in a single hour of interaction with her mother early in her third year of life (at age 2;1.11). We used a high-density database consisting of 5 hours of recordings per week together with a maternal diary for the previous 6 weeks. Of the 295 multi-word utterances on tape, 37% were 'novel' in the sense that they had not been said in their entirety before. Using a morpheme-matching method, we identified the way(s) in which each novel utterance differed from its closest match in the preceding corpus. In 74% of the cases we required only one operation to match the previous utterance and the great majority of these consisted of the substitution of a word (usually a noun) into a previous utterance or schema. Almost all the other single-operation utterances involved adding a word onto the beginning or end of a previous utterance. 26% of the novel, multi-word utterances required more than one operation to match the closest previous utterance, although many of these only involved a combination of the two operations seen for the single-operation utterances. Some others were, however, more complex to match. The results suggest that the relatively high degree of creativity in early English child language could be at least partially based upon entrenched schemas and a small number of simple operations to modify them. We discuss the implications of these results for the interplay in language production between strings registered in memory and categorial knowledge.

Utterance-final position and pitch marking aid word learning in school-age children

PubMed Central

Laaha, Sabine; Fitch, W. Tecumseh

2017-01-01

We investigated the effects of word order and prosody on word learning in school-age children. Third graders viewed photographs belonging to one of three semantic categories while hearing four-word nonsense utterances containing a target word. In the control condition, all words had the same pitch and, across trials, the position of the target word was varied systematically within each utterance. The only cue to word–meaning mapping was the co-occurrence of target words and referents. This cue was present in all conditions. In the Utterance-final condition, the target word always occurred in utterance-final position, and at the same fundamental frequency as all the other words of the utterance. In the Pitch peak condition, the position of the target word was varied systematically within each utterance across trials, and produced with pitch contrasts typical of infant-directed speech (IDS). In the Pitch peak + Utterance-final condition, the target word always occurred in utterance-final position, and was marked with a pitch contrast typical of IDS. Word learning occurred in all conditions except the control condition. Moreover, learning performance was significantly higher than that observed with simple co-occurrence (control condition) only for the Pitch peak + Utterance-final condition. We conclude that, for school-age children, the combination of words' utterance-final alignment and pitch enhancement boosts word learning. PMID:28878961

Utterance-final position and pitch marking aid word learning in school-age children.

PubMed

Filippi, Piera; Laaha, Sabine; Fitch, W Tecumseh

2017-08-01

We investigated the effects of word order and prosody on word learning in school-age children. Third graders viewed photographs belonging to one of three semantic categories while hearing four-word nonsense utterances containing a target word. In the control condition, all words had the same pitch and, across trials, the position of the target word was varied systematically within each utterance. The only cue to word-meaning mapping was the co-occurrence of target words and referents. This cue was present in all conditions. In the Utterance-final condition, the target word always occurred in utterance-final position, and at the same fundamental frequency as all the other words of the utterance. In the Pitch peak condition, the position of the target word was varied systematically within each utterance across trials, and produced with pitch contrasts typical of infant-directed speech (IDS). In the Pitch peak + Utterance-final condition, the target word always occurred in utterance-final position, and was marked with a pitch contrast typical of IDS. Word learning occurred in all conditions except the control condition. Moreover, learning performance was significantly higher than that observed with simple co-occurrence ( control condition) only for the Pitch peak + Utterance-final condition. We conclude that, for school-age children, the combination of words' utterance-final alignment and pitch enhancement boosts word learning.

Utterance rate and linguistic properties as determinants of lexical dysfluencies in children who stutter

PubMed Central

Howell, Peter; Au-Yeung, James; Pilgrim, Lesley

2007-01-01

Two important determinants of variation in stuttering frequency are utterance rate and the linguistic properties of the words being spoken. Little is known how these determinants interrelate. It is hypothesized that those linguistic factors that lead to change in word duration, alter utterance rate locally within an utterance that then gives rise to an increase in stuttering frequency. According to the hypothesis, utterance rate variation should occur locally within the linguistic segments in an utterance that is known to increase the likelihood of stuttering. The hypothesis is tested using length of tone unit as the linguistic factor. Three predictions are confirmed: Utterance rate varies locally within the tone units and this local variation affects stuttering frequency; stuttering frequency is positively related to the length of tone units; variations in utterance rate are correlated with tone unit length. Alternative theoretical formulations of these findings are considered. PMID:9921672

Auditory Cortex Processes Variation in Our Own Speech

PubMed Central

Sitek, Kevin R.; Mathalon, Daniel H.; Roach, Brian J.; Houde, John F.; Niziolek, Caroline A.; Ford, Judith M.

2013-01-01

As we talk, we unconsciously adjust our speech to ensure it sounds the way we intend it to sound. However, because speech production involves complex motor planning and execution, no two utterances of the same sound will be exactly the same. Here, we show that auditory cortex is sensitive to natural variations in self-produced speech from utterance to utterance. We recorded event-related potentials (ERPs) from ninety-nine subjects while they uttered “ah” and while they listened to those speech sounds played back. Subjects' utterances were sorted based on their formant deviations from the previous utterance. Typically, the N1 ERP component is suppressed during talking compared to listening. By comparing ERPs to the least and most variable utterances, we found that N1 was less suppressed to utterances that differed greatly from their preceding neighbors. In contrast, an utterance's difference from the median formant values did not affect N1. Trial-to-trial pitch (f0) deviation and pitch difference from the median similarly did not affect N1. We discuss mechanisms that may underlie the change in N1 suppression resulting from trial-to-trial formant change. Deviant utterances require additional auditory cortical processing, suggesting that speaking-induced suppression mechanisms are optimally tuned for a specific production. PMID:24349399

Effects of high and low constraint utterances on the production of immediate and delayed echolalia in young children with autism.

PubMed

Rydell, P J; Mirenda, P

1994-12-01

This study examined the effects of adult antecedent utterances on the occurrence and use of echolalia in children with autism during a free play setting. Adult antecedent utterances were differentiated into two types, high and low constraint, based on the degree of linguistic constraint inherent in the adult utterance and social-communicative control exerted on the child's social and verbal interaction. Results of this study identified a variety of patterns of echolalia usage following adult high and low constraint utterances. Overall results found that a majority of immediate echoes followed high constraint utterances and were primarily used as responsives, organizational devices, and cognitives. The majority of delayed echoes followed low constraint utterances and were primarily used as requestives, assertives, and cognitives. Delayed echoes were more likely than immediate echoes to be produced with evidence of comprehension, but there were no differences in comprehension within the two categories of echolalia following high and low constraint utterances. Educational implications are discussed.

Listener Reliability in Assigning Utterance Boundaries in Children's Spontaneous Speech

ERIC Educational Resources Information Center

Stockman, Ida J.

2010-01-01

Research and clinical practices often rely on an utterance unit for spoken language analysis. This paper calls attention to the problems encountered when identifying utterance boundaries in young children's spontaneous conversational speech. The results of a reliability study of utterance boundary assignment are described for 20 females with…

The Role of Utterance Length and Position in 3-Year-Olds' Production of Third Person Singular -s

ERIC Educational Resources Information Center

Mealings, Kiri T.; Demuth, Katherine

2014-01-01

Purpose: Evidence from children's spontaneous speech suggests that utterance length and utterance position may help explain why children omit grammatical morphemes in some contexts but not others. This study investigated whether increased utterance length (hence, increased grammatical complexity) adversely affects children's third person singular…

The effects of two levels of linguistic constraint on echolalia and generative language production in children with autism.

PubMed

Rydell, P J; Mirenda, P

1991-06-01

The effects of specific types of adult antecedent utterances (high vs. low constraint) on the verbal behaviors produced by three subjects with autism were examined. Adult utterance types were differentiated in terms of the amount of control the adults exhibited in their verbal interactions with the subjects during a free play setting. Videotaped interactions were analyzed and coded according to a predetermined categorical system. The results of this investigation suggest that the level of linguistic constraint exerted on the child interactants during naturalistic play sessions affected their communicative output. The overall findings suggest that (a) adult high constraint utterances elicited more verbal utterances in general, as well as a majority of the subjects' echolalia; (b) adult low constraint utterances elicited more subject high constraint utterances; and (c) the degree of constraint of adult utterances did not appear to influence the mean lengths of subjects' utterances. The results are discussed in terms of their implications for educational interventions, and suggestions are made for future research concerning the dynamics of echolalia in interactive contexts.

Performance and cross-crop resistance of Cry1F-maize selected Spodoptera frugiperda on transgenic Bt cotton: implications for resistance management

PubMed Central

Yang, Fei; Kerns, David L.; Brown, Sebe; Kurtz, Ryan; Dennehy, Tim; Braxton, Bo; Head, Graham; Huang, Fangneng

2016-01-01

Transgenic crops producing Bacillus thuringiensis (Bt) proteins have become a primary tool in pest management. Due to the intensive use of Bt crops, resistance of the fall armyworm, Spodoptera frugiperda, to Cry1F maize has occurred in Puerto Rico, Brazil, and some areas of the southeastern U.S. The sustainability of Bt crops faces a great challenge because the Cry1F-maize resistant S. frugiperda may also infest other Bt crops in multiple cropping ecosystems. Here we examined the survival and plant injury of a S. frugiperda population selected with Cry1F maize on three single-gene and five pyramided Bt cotton products. Larvae of Cry1F-susceptible (SS), -heterozygous (RS), and -resistant (RR) genotypes of S. frugiperda were all susceptible to the pyramided cotton containing Cry1Ac/Cry2Ab, Cry1Ac/Cry1F/Vip3A, Cry1Ab/Cry2Ae, or Cry1Ab/Cry2Ae/Vip3A, and the single-gene Cry2Ae cotton. Pyramided cotton containing Cry1Ac/Cry1F was effective against SS and RS, but not for RR. These findings show that the Cry1F-maize selected S. frugiperda can cause cross-crop resistance to other Bt crops expressing similar insecticidal proteins. Resistance management and pest management programs that utilize diversify mortality factors must be implemented to ensure the sustainability of Bt crops. This is especially important in areas where resistance to single-gene Bt crops is already widespread. PMID:27301612

Performance and cross-crop resistance of Cry1F-maize selected Spodoptera frugiperda on transgenic Bt cotton: implications for resistance management.

PubMed

Yang, Fei; Kerns, David L; Brown, Sebe; Kurtz, Ryan; Dennehy, Tim; Braxton, Bo; Head, Graham; Huang, Fangneng

2016-06-15

Transgenic crops producing Bacillus thuringiensis (Bt) proteins have become a primary tool in pest management. Due to the intensive use of Bt crops, resistance of the fall armyworm, Spodoptera frugiperda, to Cry1F maize has occurred in Puerto Rico, Brazil, and some areas of the southeastern U.S. The sustainability of Bt crops faces a great challenge because the Cry1F-maize resistant S. frugiperda may also infest other Bt crops in multiple cropping ecosystems. Here we examined the survival and plant injury of a S. frugiperda population selected with Cry1F maize on three single-gene and five pyramided Bt cotton products. Larvae of Cry1F-susceptible (SS), -heterozygous (RS), and -resistant (RR) genotypes of S. frugiperda were all susceptible to the pyramided cotton containing Cry1Ac/Cry2Ab, Cry1Ac/Cry1F/Vip3A, Cry1Ab/Cry2Ae, or Cry1Ab/Cry2Ae/Vip3A, and the single-gene Cry2Ae cotton. Pyramided cotton containing Cry1Ac/Cry1F was effective against SS and RS, but not for RR. These findings show that the Cry1F-maize selected S. frugiperda can cause cross-crop resistance to other Bt crops expressing similar insecticidal proteins. Resistance management and pest management programs that utilize diversify mortality factors must be implemented to ensure the sustainability of Bt crops. This is especially important in areas where resistance to single-gene Bt crops is already widespread.

The period-luminosity and period-radius relations of Type II and anomalous Cepheids in the Large and Small Magellanic Clouds

NASA Astrophysics Data System (ADS)

Groenewegen, M. A. T.; Jurkovic, M. I.

2017-07-01

Context. Type II Cepheids (T2Cs) and anomalous Cepheids (ACs) are pulsating stars that follow separate period-luminosity relations. Aims: We study the period-luminosity (PL) and period-radius (PR) relations for T2Cs and ACs in the Magellanic Clouds. Methods: In an accompanying paper we determined the luminosities and effective temperatures for the 335 T2Cs and ACs in the LMC and SMC discovered in the OGLE-III survey, by constructing the spectral energy distribution (SED) and fitting this with model atmospheres and a dust radiative transfer model (in the case of dust excess). Building on these results we studied the PL and PR relations of these sources. Using existing pulsation models for RR Lyrae and classical Cepheids we derive the period-luminosity-mass-temperature-metallicity relations and then estimate the pulsation mass. Results: The PL relation for the T2Cs does not appear to depend on metallicity and is Mbol = + 0.12-1.78log P (for P < 50 days), excluding the dusty RV Tau stars. Relations for fundamental and first overtone LMC ACs are also presented. The PR relation for T2C also shows little or no dependence on metallicity or period. Our preferred relation combines SMC and LMC stars and all T2C subclasses and is log R = 0.846 + 0.521log P. Relations for fundamental and first overtone LMC ACs are also presented. The pulsation masses from the RR Lyrae and classical Cepheid pulsation models agree well for the short period T2Cs, the BL Her subtype, and ACs, and are consistent with estimates in the literature, I.e. MBLH 0.49M⊙ and MAC 1.3M⊙, respectively. The masses of the W Vir appear similar to the BL Her. The situation for the pWVir and RV Tau stars is less clear. For many RV Tau the masses are in conflict with the standard picture of (single-star) post-AGB evolution, where the masses are either too large (≳1 M⊙) or too small (≲0.4 M⊙). Full Table 3 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/A29

Utterance Duration as It Relates to Communicative Variables in Infant Vocal Development

ERIC Educational Resources Information Center

Ramsdell-Hudock, Heather L.; Stuart, Andrew; Parham, Douglas F.

2018-01-01

Purpose: We aimed to provide novel information on utterance duration as it relates to vocal type, facial affect, gaze direction, and age in the prelinguistic/early linguistic infant. Method: Infant utterances were analyzed from longitudinal recordings of 15 infants at 8, 10, 12, 14, and 16 months of age. Utterance durations were measured and coded…

Babbling in children with neurodevelopmental disability and validity of a simplified way of measuring canonical babbling ratio.

PubMed

Nyman, Anna; Lohmander, Anette

2018-01-01

Babbling is an important precursor to speech, but has not yet been thoroughly investigated in children with neurodevelopmental disabilities. Canonical babbling ratio (CBR) is a commonly used but time-consuming measure for quantifying babbling. The aim of this study was twofold: to validate a simplified version of the CBR (CBR UTTER ), and to use this measure to determine if early precursors to speech and language development could be detected in children with different neurodevelopmental disabilities. Two different data sets were used. In Part I, CBR UTTER was compared to two other CBR measures using previously obtained phonetic transcriptions of 3571 utterances from 38 audio recordings of 12-18 month old children with and without cleft palate. In CBR UTTER , number of canonical utterances was divided by total number of utterances. In CBR syl , number of canonical syllables was divided by total number of syllables. In CBR utt , number of canonical syllables was divided by total number of utterances. High agreement was seen between CBR UTTER and CBR syl , suggesting CBR UTTER as an alternative. In Part II, babbling in children with neurodevelopmental disability was examined. Eighteen children aged 12-22 months with Down syndrome, cerebral palsy or developmental delay were audio-video recorded during interaction with a parent. Recordings were analysed by observation of babbling, consonant production, calculation of CBR UTTER , and compared to data from controls. The study group showed significantly lower occurrence of all variables, except for of plosives. The long-term relevance of the findings for the speech and language development of the children needs to be investigated.

Gi proteins regulate adenylyl cyclase activity independent of receptor activation.

PubMed

Melsom, Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav; Krobert, Kurt Allen

2014-01-01

Despite the view that only β2- as opposed to β1-adrenoceptors (βARs) couple to G(i), some data indicate that the β1AR-evoked inotropic response is also influenced by the inhibition of Gi. Therefore, we wanted to determine if Gi exerts tonic receptor-independent inhibition upon basal adenylyl cyclase (AC) activity in cardiomyocytes. We used the Gs-selective (R,R)- and the Gs- and G(i)-activating (R,S)-fenoterol to selectively activate β2ARs (β1AR blockade present) in combination with Gi inactivation with pertussis toxin (PTX). We also determined the effect of PTX upon basal and forskolin-mediated responses. Contractility was measured ex vivo in left ventricular strips and cAMP accumulation was measured in isolated ventricular cardiomyocytes from adult Wistar rats. PTX amplified both the (R,R)- and (R,S)-fenoterol-evoked maximal inotropic response and concentration-dependent increases in cAMP accumulation. The EC50 values of fenoterol matched published binding affinities. The PTX enhancement of the Gs-selective (R,R)-fenoterol-mediated responses suggests that Gi regulates AC activity independent of receptor coupling to Gi protein. Consistent with this hypothesis, forskolin-evoked cAMP accumulation was increased and inotropic responses to forskolin were potentiated by PTX treatment. In non-PTX-treated tissue, phosphodiesterase (PDE) 3 and 4 inhibition or removal of either constitutive muscarinic receptor activation of Gi with atropine or removal of constitutive adenosine receptor activation with CGS 15943 had no effect upon contractility. However, in PTX-treated tissue, PDE3 and 4 inhibition alone increased basal levels of cAMP and accordingly evoked a large inotropic response. Together, these data indicate that Gi exerts intrinsic receptor-independent inhibitory activity upon AC. We propose that PTX treatment shifts the balance of intrinsic G(i) and Gs activity upon AC towards Gs, enhancing the effect of all cAMP-mediated inotropic agents.

Gi Proteins Regulate Adenylyl Cyclase Activity Independent of Receptor Activation

PubMed Central

Melsom, Caroline Bull; Ørstavik, Øivind; Osnes, Jan-Bjørn; Skomedal, Tor; Levy, Finn Olav; Krobert, Kurt Allen

2014-01-01

Background and purpose Despite the view that only β2- as opposed to β1-adrenoceptors (βARs) couple to Gi, some data indicate that the β1AR-evoked inotropic response is also influenced by the inhibition of Gi. Therefore, we wanted to determine if Gi exerts tonic receptor-independent inhibition upon basal adenylyl cyclase (AC) activity in cardiomyocytes. Experimental approach We used the Gs-selective (R,R)- and the Gs- and Gi-activating (R,S)-fenoterol to selectively activate β2ARs (β1AR blockade present) in combination with Gi inactivation with pertussis toxin (PTX). We also determined the effect of PTX upon basal and forskolin-mediated responses. Contractility was measured ex vivo in left ventricular strips and cAMP accumulation was measured in isolated ventricular cardiomyocytes from adult Wistar rats. Key results PTX amplified both the (R,R)- and (R,S)-fenoterol-evoked maximal inotropic response and concentration-dependent increases in cAMP accumulation. The EC50 values of fenoterol matched published binding affinities. The PTX enhancement of the Gs-selective (R,R)-fenoterol-mediated responses suggests that Gi regulates AC activity independent of receptor coupling to Gi protein. Consistent with this hypothesis, forskolin-evoked cAMP accumulation was increased and inotropic responses to forskolin were potentiated by PTX treatment. In non-PTX-treated tissue, phosphodiesterase (PDE) 3 and 4 inhibition or removal of either constitutive muscarinic receptor activation of Gi with atropine or removal of constitutive adenosine receptor activation with CGS 15943 had no effect upon contractility. However, in PTX-treated tissue, PDE3 and 4 inhibition alone increased basal levels of cAMP and accordingly evoked a large inotropic response. Conclusions and implications Together, these data indicate that Gi exerts intrinsic receptor-independent inhibitory activity upon AC. We propose that PTX treatment shifts the balance of intrinsic Gi and Gs activity upon AC towards Gs, enhancing the effect of all cAMP-mediated inotropic agents. PMID:25203113

Effects of High and Low Constraint Utterances on the Production of Immediate and Delayed Echolalia in Young Children with Autism.

ERIC Educational Resources Information Center

Rydell, Patrick J.; Mirenda, Pat

1994-01-01

Examination of the effects of adult antecedent utterances on echolalia in seven male children with autism (ages five and six) during free play found that most immediate echoes followed high constraint utterances and were used as responsives, organizational devices, and cognitives. Most delayed echoes followed low constraint utterances and were…

Construction of graphic symbol utterances by children, teenagers, and adults: the effect of structure and task demands.

PubMed

Trudeau, Natacha; Sutton, Ann; Dagenais, Emmanuelle; de Broeck, Sophie; Morford, Jill

2007-10-01

This study investigated the impact of syntactic complexity and task demands on construction of utterances using picture communication symbols by participants from 3 age groups with no communication disorders. Participants were 30 children (7;0 [years;months] to 8;11), 30 teenagers (12;0 to 13;11), and 30 adults (18 years and above). All participants constructed graphic symbol utterances to describe photographs presented with spoken French stimuli. Stimuli included simple and complex (object relative and subject relative) utterances describing the photographs, which were presented either 1 at a time (neutral condition) or in an array of 4 (contrast condition). Simple utterances lead to more uniform response patterns than complex utterances. Among complex utterances, subject relative sentences appeared more difficult to convey. Increasing the need for message clarity (i.e., contrast condition) elicited changes in the production of graphic symbol sequences for complex propositions. The effects of syntactic complexity and task demands were more pronounced for children. Graphic symbol utterance construction appears to involve more than simply transferring spoken language skills. One possible explanation is that this type of task requires higher levels of metalinguistic ability. Clinical implications and directions for further research are discussed.

Anaerobic digestion of Jatropha curcas L. press cake and effects of an iron-additive.

PubMed

Schmidt, Thomas

2011-11-01

Oil production from Jatropha curcas L. seeds generates large amounts of Jatropha press cake (JPC) which can be utilized as a substrate for biogas production. The objective of this work was to investigate anaerobic mono-digestion of JPC and the effects of an iron additive (IA) on gas quality and process stability during the increase of the organic loading rate (OLR). With the increase of the OLR from 1.3 to 3.2 g(VS) L(-1) day(-1), the biogas yield in the reference reactor (RR) without IA decreased from 512 to 194 L(N) kg(VS) (-1) and the CH₄ concentration decreased from 69.3 to 44.4%. In the iron additive reactor (IAR), the biogas yield decreased from 530 to 462 L(N) kg(VS) (-1) and the CH₄ concentration decreased from 69.4 to 61.1%. The H₂S concentration in the biogas was reduced by addition of the IA to values below 258 ppm in the IAR while H₂S concentration in the RR increased and exceeded the detection limit of 5000 ppm. The acid capacity (AC) in the RR increased to more than 20 g L(-1), indicating an accumulation of organic acids caused by process instability. AC values in the IAR remained stable at values below 5 g L(-1). The results demonstrate that JPC can be used as sole substrate for anaerobic digestion up to an OLR of 2.4 g(VS) l(-1) day(-1). The addition of IA has effectively decreased the H(2)S content in the biogas and has improved the stability of the anaerobic process and the biogas quality.

Gastro-esophageal reflux and antisecretory drugs use among patients with chronic autoimmune atrophic gastritis: a study with pH-impedance monitoring.

PubMed

Tenca, A; Massironi, S; Pugliese, D; Consonni, D; Mauro, A; Cavalcoli, F; Franchina, M; Spampatti, M; Conte, D; Penagini, R

2016-02-01

Patients with chronic autoimmune atrophic gastritis (CAAG) often refer digestive symptoms and are prescribed antisecretory medications. Aims were to investigate: (i) gastro-esophageal reflux (GER), (ii) psychopathological profile, (iii) frequency of use and clinical benefit of antisecretory drugs. Prospective observational study on 41 CAAG patients who underwent: 24 h multichannel intra-luminal impedance-pH (MII-pH) monitoring off-therapy, standardized medical interview and psychological questionnaire (i.e., SCL-90R). The medical interview was repeated at least 1 month after MII-pH in patients who were using antisecretory drugs. Statistical analysis was performed calculating median (10th-90th percentiles) and risk ratios (RR) with 95% confidence interval. Median intra-gastric pH was 6.2 (4.6-7.0). One patient had acid reflux (AC) associated with symptoms, five had increased total reflux number and four had symptoms associated to non-acid reflux (NA) (patients referred as 'GER positive'). Using patients 'GER negative' with normal SCL-90R as reference, the RR of being symptomatic in patients GER positive was 2.1 (1.1-4.1) if SCL-90R was normal and 0.9 (0.5-1.7) if it was altered (difference in RR significant being p = 0.04). Seventeen/28 (61%) symptomatic patients were on antisecretory drugs, which were stopped in 16 of them according to results of MII-pH and clinical evaluation after 574 days (48-796) showed that symptoms were unchanged. In patients with CAAG (i) AC reflux rarely occurred whereas increased NA reflux was not infrequent both being related to symptoms in some patients, (ii) psychopathological profile has a role in symptoms' occurrence, (iii) antisecretory drugs were generally inappropriately used and clinically ineffective. © 2015 John Wiley & Sons Ltd.

Utterance complexity and stuttering on function words in preschool-age children who stutter.

PubMed

Richels, Corrin; Buhr, Anthony; Conture, Edward; Ntourou, Katerina

2010-09-01

The purpose of the present investigation was to examine the relation between utterance complexity and utterance position and the tendency to stutter on function words in preschool-age children who stutter (CWS). Two separate studies involving two different groups of participants (Study 1, n=30; Study 2, n=30) were conducted. Participants were preschool-age CWS between the age of 3, 0 and 5, 11 who engaged in 15-20min parent-child conversational interactions. From audio-video recordings of each interaction, every child utterance of each parent-child sample was transcribed. From these transcripts, for each participant, measures of language (e.g., length and complexity) and measures of stuttering (e.g., word type and utterance position) were obtained. Results of Study 1 indicated that children stuttered more frequently on function words, but that this tendency was not greater for complex than simple utterances. Results of Study 2, involving the assessment of utterance position and MLU quartile, indicated that that stuttering was more likely to occur with increasing sentence length, and that stuttering tended to occur at the utterance-initial position, the position where function words were also more likely to occur. Findings were taken to suggest that, although word-level influences cannot be discounted, utterance-level influences contribute to the loci of stuttering in preschool-age children, and may help account for developmental changes in the loci of stuttering. The reader will learn about and be able to: (a) describe the influence of word type (function versus content words), and grammatical complexity, on disfluent speech; (b) compare the effect of stuttering frequency based on the position of the word in the utterance; (c) discuss the contribution of utterance position on the frequency of stuttering on function words; and (d) explain possible reasons why preschoolers stutter more frequently on function words than content words.

Theory of mind in utterance interpretation: the case from clinical pragmatics.

PubMed

Cummings, Louise

2015-01-01

The cognitive basis of utterance interpretation is an area that continues to provoke intense theoretical debate among pragmatists. That utterance interpretation involves some type of mind-reading or theory of mind (ToM) is indisputable. However, theorists are divided on the exact nature of this ToM-based mechanism. In this paper, it is argued that the only type of ToM-based mechanism that can adequately represent the cognitive basis of utterance interpretation is one which reflects the rational, intentional, holistic character of interpretation. Such a ToM-based mechanism is supported on conceptual and empirical grounds. Empirical support for this view derives from the study of children and adults with pragmatic disorders. Specifically, three types of clinical case are considered. In the first case, evidence is advanced which indicates that individuals with pragmatic disorders exhibit deficits in reasoning and the use of inferences. These deficits compromise the ability of children and adults with pragmatic disorders to comply with the rational dimension of utterance interpretation. In the second case, evidence is presented which suggests that subjects with pragmatic disorders struggle with the intentional dimension of utterance interpretation. This dimension extends beyond the recognition of communicative intentions to include the attribution of a range of cognitive and affective mental states that play a role in utterance interpretation. In the third case, evidence is presented that children and adults with pragmatic disorders struggle with the holistic character of utterance interpretation. This serves to distort the contexts in which utterances are processed for their implicated meanings. The paper concludes with some thoughts about the role of theorizing in relation to utterance interpretation.

Language-based communication strategies that support person-centered communication with persons with dementia.

PubMed

Savundranayagam, Marie Y; Moore-Nielsen, Kelsey

2015-10-01

There are many recommended language-based strategies for effective communication with persons with dementia. What is unknown is whether effective language-based strategies are also person centered. Accordingly, the objective of this study was to examine whether language-based strategies for effective communication with persons with dementia overlapped with the following indicators of person-centered communication: recognition, negotiation, facilitation, and validation. Conversations (N = 46) between staff-resident dyads were audio-recorded during routine care tasks over 12 weeks. Staff utterances were coded twice, using language-based and person-centered categories. There were 21 language-based categories and 4 person-centered categories. There were 5,800 utterances transcribed: 2,409 without indicators, 1,699 coded as language or person centered, and 1,692 overlapping utterances. For recognition, 26% of utterances were greetings, 21% were affirmations, 13% were questions (yes/no and open-ended), and 15% involved rephrasing. Questions (yes/no, choice, and open-ended) comprised 74% of utterances that were coded as negotiation. A similar pattern was observed for utterances coded as facilitation where 51% of utterances coded as facilitation were yes/no questions, open-ended questions, and choice questions. However, 21% of facilitative utterances were affirmations and 13% involved rephrasing. Finally, 89% of utterances coded as validation were affirmations. The findings identify specific language-based strategies that support person-centered communication. However, between 1 and 4, out of a possible 21 language-based strategies, overlapped with at least 10% of utterances coded as each person-centered indicator. This finding suggests that staff need training to use more diverse language strategies that support personhood of residents with dementia.

Theory of mind in utterance interpretation: the case from clinical pragmatics

PubMed Central

Cummings, Louise

2015-01-01

The cognitive basis of utterance interpretation is an area that continues to provoke intense theoretical debate among pragmatists. That utterance interpretation involves some type of mind-reading or theory of mind (ToM) is indisputable. However, theorists are divided on the exact nature of this ToM-based mechanism. In this paper, it is argued that the only type of ToM-based mechanism that can adequately represent the cognitive basis of utterance interpretation is one which reflects the rational, intentional, holistic character of interpretation. Such a ToM-based mechanism is supported on conceptual and empirical grounds. Empirical support for this view derives from the study of children and adults with pragmatic disorders. Specifically, three types of clinical case are considered. In the first case, evidence is advanced which indicates that individuals with pragmatic disorders exhibit deficits in reasoning and the use of inferences. These deficits compromise the ability of children and adults with pragmatic disorders to comply with the rational dimension of utterance interpretation. In the second case, evidence is presented which suggests that subjects with pragmatic disorders struggle with the intentional dimension of utterance interpretation. This dimension extends beyond the recognition of communicative intentions to include the attribution of a range of cognitive and affective mental states that play a role in utterance interpretation. In the third case, evidence is presented that children and adults with pragmatic disorders struggle with the holistic character of utterance interpretation. This serves to distort the contexts in which utterances are processed for their implicated meanings. The paper concludes with some thoughts about the role of theorizing in relation to utterance interpretation. PMID:26379602

Impact of an Early Invasive Strategy versus Conservative Strategy for Unstable Angina and Non-ST Elevation Acute Coronary Syndrome in Patients with Chronic Kidney Disease: A Systematic Review

PubMed Central

Shaw, Catriona; Nitsch, Dorothea; Lee, Jasmine; Fogarty, Damian; Sharpe, Claire C.

2016-01-01

Background Clinical practice guidelines support an early invasive approach after NSTE-ACS in patients with chronic kidney disease (CKD). There is no direct randomised controlled trial evidence in the CKD population, and whether the benefit of an early invasive approach is maintained across the spectrum of severity of CKD remains controversial. Methods We conducted a systematic review to evaluate the association between an early invasive approach and all-cause mortality in patients with CKD. We searched MEDLINE and EMBASE (1990-May 2015) and article reference lists. Data describing study design, participants, invasive management strategies, renal function, all-cause mortality and risk of bias were extracted. Results 3,861 potentially relevant studies were identified. Ten studies, representing data on 147,908 individuals with NSTE-ACS met the inclusion criteria. Qualitative heterogeneity in the definitions of early invasive approach, comparison groups and renal dysfunction existed. Meta-analysis of the RCT derived and observational data were generally supportive of an early invasive approach in CKD (RR0.76 (95% CI 0.49–1.17) and RR0.50 (95%CI 0.42–0.59) respectively). Meta-analysis of the observational studies demonstrated a large degree of heterogeneity (I2 79%) driven in part by study size and heterogeneity across various kidney function levels. Conclusions The observational data support that an early invasive approach after NSTE-ACS confers a survival benefit in those with early-moderate CKD. Local opportunities for quality improvement should be sought. Those with severe CKD and the dialysis population are high risk and under-studied. Novel and inclusive approaches for CKD and dialysis patients in cardiovascular clinical trials are needed. PMID:27195786

Voice recognition through phonetic features with Punjabi utterances

NASA Astrophysics Data System (ADS)

Kaur, Jasdeep; Juglan, K. C.; Sharma, Vishal; Upadhyay, R. K.

2017-07-01

This paper deals with perception and disorders of speech in view of Punjabi language. Visualizing the importance of voice identification, various parameters of speaker identification has been studied. The speech material was recorded with a tape recorder in their normal and disguised mode of utterances. Out of the recorded speech materials, the utterances free from noise, etc were selected for their auditory and acoustic spectrographic analysis. The comparison of normal and disguised speech of seven subjects is reported. The fundamental frequency (F0) at similar places, Plosive duration at certain phoneme, Amplitude ratio (A1:A2) etc. were compared in normal and disguised speech. It was found that the formant frequency of normal and disguised speech remains almost similar only if it is compared at the position of same vowel quality and quantity. If the vowel is more closed or more open in the disguised utterance the formant frequency will be changed in comparison to normal utterance. The ratio of the amplitude (A1: A2) is found to be speaker dependent. It remains unchanged in the disguised utterance. However, this value may shift in disguised utterance if cross sectioning is not done at the same location.

Infants' Behaviors as Antecedents and Consequents of Mothers' Responsive and Directive Utterances

ERIC Educational Resources Information Center

Masur, Elise Frank; Flynn, Valerie; Lloyd, Carrie A.

2013-01-01

To investigate possible influences on and consequences of mothers' speech, specific infant behaviors preceding and following four pragmatic categories of mothers' utterances--responsive utterances, supportive behavioral directives, intrusive behavioral directives, and intrusive attentional directives--were examined longitudinally during dyadic…

Effects of utterance length and vocal loudness on speech breathing in older adults.

PubMed

Huber, Jessica E

2008-12-31

Age-related reductions in pulmonary elastic recoil and respiratory muscle strength can affect how older adults generate subglottal pressure required for speech production. The present study examined age-related changes in speech breathing by manipulating utterance length and loudness during a connected speech task (monologue). Twenty-three older adults and twenty-eight young adults produced a monologue at comfortable loudness and pitch and with multi-talker babble noise playing in the room to elicit louder speech. Dependent variables included sound pressure level, speech rate, and lung volume initiation, termination, and excursion. Older adults produced shorter utterances than young adults overall. Age-related effects were larger for longer utterances. Older adults demonstrated very different lung volume adjustments for loud speech than young adults. These results suggest that older adults have a more difficult time when the speech system is being taxed by both utterance length and loudness. The data were consistent with the hypothesis that both young and older adults use utterance length in premotor speech planning processes.

Utterance independent bimodal emotion recognition in spontaneous communication

NASA Astrophysics Data System (ADS)

Tao, Jianhua; Pan, Shifeng; Yang, Minghao; Li, Ya; Mu, Kaihui; Che, Jianfeng

2011-12-01

Emotion expressions sometimes are mixed with the utterance expression in spontaneous face-to-face communication, which makes difficulties for emotion recognition. This article introduces the methods of reducing the utterance influences in visual parameters for the audio-visual-based emotion recognition. The audio and visual channels are first combined under a Multistream Hidden Markov Model (MHMM). Then, the utterance reduction is finished by finding the residual between the real visual parameters and the outputs of the utterance related visual parameters. This article introduces the Fused Hidden Markov Model Inversion method which is trained in the neutral expressed audio-visual corpus to solve the problem. To reduce the computing complexity the inversion model is further simplified to a Gaussian Mixture Model (GMM) mapping. Compared with traditional bimodal emotion recognition methods (e.g., SVM, CART, Boosting), the utterance reduction method can give better results of emotion recognition. The experiments also show the effectiveness of our emotion recognition system when it was used in a live environment.

Uptake and efficacy of a systematic intensive smoking cessation intervention using motivational interviewing for smokers hospitalised for an acute coronary syndrome: a multicentre before-after study with parallel group comparisons.

PubMed

Auer, Reto; Gencer, Baris; Tango, Rodrigo; Nanchen, David; Matter, Christian M; Lüscher, Thomas Felix; Windecker, Stephan; Mach, François; Cornuz, Jacques; Humair, Jean-Paul; Rodondi, Nicolas

2016-09-20

To compare the efficacy of a proactive approach with a reactive approach to offer intensive smoking cessation intervention using motivational interviewing (MI). Before-after comparison in 2 academic hospitals with parallel comparisons in 2 control hospitals. Academic hospitals in Switzerland. Smokers hospitalised for an acute coronary syndrome (ACS). In the intervention hospitals during the intervention phase, a resident physician trained in MI systematically offered counselling to all smokers admitted for ACS, followed by 4 telephone counselling sessions over 2 months by a nurse trained in MI. In the observation phase, the in-hospital intervention was offered only to patients whose clinicians requested a smoking cessation intervention. In the control hospitals, no intensive smoking cessation intervention was offered. The primary outcome was 1 week smoking abstinence (point prevalence) at 12 months. Secondary outcomes were the number of smokers who received the in-hospital smoking cessation intervention and the duration of the intervention. In the intervention centres during the intervention phase, 87% of smokers (N=193/225) received a smoking cessation intervention compared to 22% in the observational phase (p<0.001). Median duration of counselling was 50 min. During the intervention phase, 78% received a phone follow-up for a median total duration of 42 min in 4 sessions. Prescription of nicotine replacement therapy at discharge increased from 18% to 58% in the intervention phase (risk ratio (RR): 3.3 (95% CI 2.4 to 4.3; p≤0.001). Smoking cessation at 12-month increased from 43% to 51% comparing the observation and intervention phases (RR=1.20, 95% CI 0.98 to 1.46; p=0.08; 97% with outcome assessment). In the control hospitals, the RR for quitting was 1.02 (95% CI 0.84 to 1.25; p=0.8, 92% with outcome assessment). A proactive strategy offering intensive smoking cessation intervention based on MI to all smokers hospitalised for ACS significantly increases the uptake of smoking cessation counselling and might increase smoking abstinence at 12 months. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Effects of Conversational Pressures on Speech Planning

ERIC Educational Resources Information Center

Swets, Benjamin; Jacovina, Matthew E.; Gerrig, Richard J.

2013-01-01

In ordinary conversation, speakers experience pressures both to produce utterances suited to particular addressees and to do so with minimal delay. To document the impact of these conversational pressures, our experiment asked participants to produce brief utterances to describe visual displays. We complicated utterance planning by including…

Mikhail Bakhtin and "Expressive Discourse."

ERIC Educational Resources Information Center

Ewald, Helen Rothschild

Mikhail Bakhtin's concept of dialogism has applications to rhetoric and composition instruction. Dialogism, sometimes translated as intertextuality, is the term Bakhtin used to designate the relation of one utterance to other utterances. Dialogism is not dialogue in the usual sense of the word; it is the context which informs utterance, and…

An auditory cue-depreciation effect.

PubMed

Gibson, J M; Watkins, M J

1991-01-01

An experiment is reported in which subjects first heard a list of words and then tried to identify these same words from degraded utterances. Paralleling previous findings in the visual modality, the probability of identifying a given utterance was reduced when the utterance was immediately preceded by other, more degraded, utterances of the same word. A second experiment replicated this "cue-depreciation effect" and in addition found the effect to be weakened, if not eliminated, when the target word was not included in the initial list or when the test was delayed by two days.

Influence of interlocutor/reader on utterance in reflective writing and interview

NASA Astrophysics Data System (ADS)

Collyer, Vivian M.

2010-03-01

The influence of the Other on utterance is foundational to language study. This analysis contrasts this influence within two modes of communication: reflective writing and interview. The data source is derived from the reflective writings and interview transcripts of a twelfth-grade physics student. In this student's case, reflective writing includes extensive utterances, utilizing rhetorical devices to persuade and reconcile with his reader. In the interview, on-going back-and-forth utterances allow the two participants to negotiate a co-constructed meaning for religion. Implications for the classroom are briefly discussed.

Examination of the Locus of Positional Effects on Children's Production of Plural -s: Considerations From Local and Global Speech Planning.

PubMed

Theodore, Rachel M; Demuth, Katherine; Shattuck-Hufnagel, Stefanie

2015-06-01

Prosodic and articulatory factors influence children's production of inflectional morphemes. For example, plural -s is produced more reliably in utterance-final compared to utterance-medial position (i.e., the positional effect), which has been attributed to the increased planning time in utterance-final position. In previous investigations of plural -s, utterance-medial plurals were followed by a stop consonant (e.g., dogsbark), inducing high articulatory complexity. We examined whether the positional effect would be observed if the utterance-medial context were simplified to a following vowel. An elicited imitation task was used to collect productions of plural nouns from 2-year-old children. Nouns were elicited utterance-medially and utterance-finally, with the medial plural followed by either a stressed or an unstressed vowel. Acoustic analysis was used to identify evidence of morpheme production. The positional effect was absent when the morpheme was followed by a vowel (e.g., dogseat). However, it returned when the vowel-initial word contained 2 syllables (e.g., dogsarrive), suggesting that the increased processing load in the latter condition negated the facilitative effect of the easy articulatory context. Children's productions of grammatical morphemes reflect a rich interaction between emerging levels of linguistic competence, raising considerations for diagnosis and rehabilitation of language disorders.

Nonhomogeneous transfer reveals specificity in speech motor learning.

PubMed

Rochet-Capellan, Amélie; Richer, Lara; Ostry, David J

2012-03-01

Does motor learning generalize to new situations that are not experienced during training, or is motor learning essentially specific to the training situation? In the present experiments, we use speech production as a model to investigate generalization in motor learning. We tested for generalization from training to transfer utterances by varying the acoustical similarity between these two sets of utterances. During the training phase of the experiment, subjects received auditory feedback that was altered in real time as they repeated a single consonant-vowel-consonant utterance. Different groups of subjects were trained with different consonant-vowel-consonant utterances, which differed from a subsequent transfer utterance in terms of the initial consonant or vowel. During the adaptation phase of the experiment, we observed that subjects in all groups progressively changed their speech output to compensate for the perturbation (altered auditory feedback). After learning, we tested for generalization by having all subjects produce the same single transfer utterance while receiving unaltered auditory feedback. We observed limited transfer of learning, which depended on the acoustical similarity between the training and the transfer utterances. The gradients of generalization observed here are comparable to those observed in limb movement. The present findings are consistent with the conclusion that speech learning remains specific to individual instances of learning.

Nonhomogeneous transfer reveals specificity in speech motor learning

PubMed Central

Rochet-Capellan, Amélie; Richer, Lara

2012-01-01

Does motor learning generalize to new situations that are not experienced during training, or is motor learning essentially specific to the training situation? In the present experiments, we use speech production as a model to investigate generalization in motor learning. We tested for generalization from training to transfer utterances by varying the acoustical similarity between these two sets of utterances. During the training phase of the experiment, subjects received auditory feedback that was altered in real time as they repeated a single consonant-vowel-consonant utterance. Different groups of subjects were trained with different consonant-vowel-consonant utterances, which differed from a subsequent transfer utterance in terms of the initial consonant or vowel. During the adaptation phase of the experiment, we observed that subjects in all groups progressively changed their speech output to compensate for the perturbation (altered auditory feedback). After learning, we tested for generalization by having all subjects produce the same single transfer utterance while receiving unaltered auditory feedback. We observed limited transfer of learning, which depended on the acoustical similarity between the training and the transfer utterances. The gradients of generalization observed here are comparable to those observed in limb movement. The present findings are consistent with the conclusion that speech learning remains specific to individual instances of learning. PMID:22190628

Stuttering Frequency in Relation to Lexical Diversity, Syntactic Complexity, and Utterance Length

ERIC Educational Resources Information Center

Wagovich, Stacy A.; Hall, Nancy E.

2018-01-01

Children's frequency of stuttering can be affected by utterance length, syntactic complexity, and lexical content of language. Using a unique small-scale within-subjects design, this study explored whether language samples that contain more stuttering have (a) longer, (b) syntactically more complex, and (c) lexically more diverse utterances than…

Exploring the Utility of a School-Age Narrative Microstructure Index: Proportion of Restricted Utterances

ERIC Educational Resources Information Center

Jerger, Sara; Thorne, John C.

2016-01-01

Purpose: This research attempted to replicate Hoffman's 2009 finding that the proportion of narrative utterances with semantic or syntactic errors (i.e., = 14% "restricted utterances") can differentiate school-age children with typical development from those with language impairment with a sensitivity of 83% and specificity of 88%.…

The Coordinated Interplay of Scene, Utterance, and World Knowledge: Evidence from Eye Tracking

ERIC Educational Resources Information Center

Knoeferle, Pia; Crocker, Matthew W.

2006-01-01

Two studies investigated the interaction between utterance and scene processing by monitoring eye movements in agent-action-patient events, while participants listened to related utterances. The aim of Experiment 1 was to determine if and when depicted events are used for thematic role assignment and structural disambiguation of temporarily…

Convergent and Divergent Validity of the Grammaticality and Utterance Length Instrument

ERIC Educational Resources Information Center

Castilla-Earls, Anny; Fulcher-Rood, Katrina

2018-01-01

Purpose: This feasibility study examines the convergent and divergent validity of the Grammaticality and Utterance Length Instrument (GLi), a tool designed to assess the grammaticality and average utterance length of a child's prerecorded story retell. Method: Three raters used the GLi to rate audio-recorded story retells from 100 English-speaking…

Persistence of Emphasis in Language Production: A Cross-Linguistic Approach

ERIC Educational Resources Information Center

Bernolet, Sarah; Hartsuiker, Robert J.; Pickering, Martin J.

2009-01-01

This study investigates the way in which speakers determine which aspects of an utterance to emphasize and how this affects the form of utterances. To do this, we ask whether the binding between emphasis and thematic roles persists between utterances. In one within-language (Dutch-Dutch) and three cross-linguistic (Dutch-English) structural…

Two-year outcome after early or late Intervention in non-ST elevation acute coronary syndrome

PubMed Central

Badings, Erik A; Remkes, Wouter S; The, Salem H K; Dambrink, Jan-Henk E; Tjeerdsma, Geert; Rasoul, Saman; Timmer, Jorik R; van der Wielen, Marloes L J; Lok, Dirk J A; Hermanides, Renicus S; Van Wijngaarden, Jan; Suryapranata, Harry; van ’t Hof, Arnoud W J

2017-01-01

Objective To compare long-term outcome of an early to a delayed invasive strategy in high-risk patients with non-ST elevation acute coronary syndrome (NSTE-ACS). Methods This prospective, multicentre trial included patients with NSTE-ACS and at least two out of three of the following high-risk criteria: (1) evidence of extensive myocardial ischaemia on ECG, (2) elevated biomarkers for myocardial necrosis and (3) age above 65 years. Patients were randomised to either an early (angiography and revascularisation if appropriate <12 hours) or a delayed invasive strategy (>48 hours after randomisation). Endpoint for this prespecified long-term follow-up was the composite incidence of death or reinfarction after 2 years. Data collection was performed by telephone contact with the patients, their relatives or general practitioner and by review of hospital records. Results Endpoint status after 2-year follow-up was collected in 521 of 542 initially enrolled patients. Incidence of death or reinfarction was 11.8% in the early and 13.1% in the delayed treatment group (relative risk (RR)=0.90, 95% CI 0.57 to 1.42). No significant differences were found in occurrence of the individual components of the primary endpoint: death 6.1% vs 8.9%, RR 0.69 (95% CI 0.37 to 1.27), reinfarction 6.5% vs 5.4%, RR 1.20 (95% CI 0.60 to 2.38). Post-hoc subgroup analysis showed statistical significant interaction between age and treatment strategy on outcome (p=0.02). Conclusions After 2 years follow-up, no difference in incidence of death or reinfarction was seen between early to late invasive strategy. These findings are in line with results of other studies with longer follow-up. Older patients seem to benefit more from early invasive treatment. PMID:28409008

Morbidity and Mortality Weekly Report. Volume 47, Number RR-3. Recommendations to Prevent and Control Iron Deficiency in the United States.

DTIC Science & Technology

1998-04-03

adverse birth outcomes. Some studies have indicated that adequate iron supplementation during pregnancy reduces the prevalence of iron- deficiency...iron intake during pregnancy has not resulted in a reduced prevalence of anemia among low-income, pregnant women (4,9,105). Evidence on iron...during pregnancy . Am J Obstet Gynecol 1995;173(1):205-9. 45. Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in

A New Type of Carbon Nanostructure Formed Within a Metal-Matrix

DTIC Science & Technology

2012-06-01

A New Type of Carbon Nanostructure Formed Within a Metal-Matrix 1 Lourdes Salamanca-Riba, 1 Romaine Isaacs, 2 Azzam N. Mansour, 3 Adam Hall, 2...HAADF imaging. REFERENCES [1] D.A. Muller, Y. Tzou, R. Raj, and J . Silcox, Nature 366, 725 (1993). [2] R.R. Schlittler, J.W. Seo, J.K...Gimzewiski, C. Durkan, M.S.M. Saifullah, M.E. Welland, Science 292, 1136 (2001). [3] A.C. Ferrari, and J . Robertson, Phys. Rev. B 61, 14095 (2000). [4

Utterance Complexity and Stuttering on Function Words in Preschool-Age Children Who Stutter

ERIC Educational Resources Information Center

Richels, Corrin; Buhr, Anthony; Conture, Edward; Ntourou, Katerina

2010-01-01

The purpose of the present investigation was to examine the relation between utterance complexity and utterance position and the tendency to stutter on function words in preschool-age children who stutter (CWS). Two separate studies involving two different groups of participants (Study 1, n = 30; Study 2, n = 30) were conducted. Participants were…

Examination of the Locus of Positional Effects on Children's Production of Plural -"s": Considerations from Local and Global Speech Planning

ERIC Educational Resources Information Center

Theodore, Rachel M.; Demuth, Katherine; Shattuck-Hufnagel, Stefanie

2015-01-01

Purpose: Prosodic and articulatory factors influence children's production of inflectional morphemes. For example, plural -"s" is produced more reliably in utterance-final compared to utterance-medial position (i.e., the positional effect), which has been attributed to the increased planning time in utterance-final position. In previous…

Feeling backwards? How temporal order in speech affects the time course of vocal emotion recognition

PubMed Central

Rigoulot, Simon; Wassiliwizky, Eugen; Pell, Marc D.

2013-01-01

Recent studies suggest that the time course for recognizing vocal expressions of basic emotion in speech varies significantly by emotion type, implying that listeners uncover acoustic evidence about emotions at different rates in speech (e.g., fear is recognized most quickly whereas happiness and disgust are recognized relatively slowly; Pell and Kotz, 2011). To investigate whether vocal emotion recognition is largely dictated by the amount of time listeners are exposed to speech or the position of critical emotional cues in the utterance, 40 English participants judged the meaning of emotionally-inflected pseudo-utterances presented in a gating paradigm, where utterances were gated as a function of their syllable structure in segments of increasing duration from the end of the utterance (i.e., gated syllable-by-syllable from the offset rather than the onset of the stimulus). Accuracy for detecting six target emotions in each gate condition and the mean identification point for each emotion in milliseconds were analyzed and compared to results from Pell and Kotz (2011). We again found significant emotion-specific differences in the time needed to accurately recognize emotions from speech prosody, and new evidence that utterance-final syllables tended to facilitate listeners' accuracy in many conditions when compared to utterance-initial syllables. The time needed to recognize fear, anger, sadness, and neutral from speech cues was not influenced by how utterances were gated, although happiness and disgust were recognized significantly faster when listeners heard the end of utterances first. Our data provide new clues about the relative time course for recognizing vocally-expressed emotions within the 400–1200 ms time window, while highlighting that emotion recognition from prosody can be shaped by the temporal properties of speech. PMID:23805115

Effects of Type of Agreement Violation and Utterance Position on the Auditory Processing of Subject-Verb Agreement: An ERP Study

PubMed Central

Dube, Sithembinkosi; Kung, Carmen; Peter, Varghese; Brock, Jon; Demuth, Katherine

2016-01-01

Previous ERP studies have often reported two ERP components—LAN and P600—in response to subject-verb (S-V) agreement violations (e.g., the boys *runs). However, the latency, amplitude and scalp distribution of these components have been shown to vary depending on various experiment-related factors. One factor that has not received attention is the extent to which the relative perceptual salience related to either the utterance position (verbal inflection in utterance-medial vs. utterance-final contexts) or the type of agreement violation (errors of omission vs. errors of commission) may influence the auditory processing of S-V agreement. The lack of reports on these effects in ERP studies may be due to the fact that most studies have used the visual modality, which does not reveal acoustic information. To address this gap, we used ERPs to measure the brain activity of Australian English-speaking adults while they listened to sentences in which the S-V agreement differed by type of agreement violation and utterance position. We observed early negative and positive clusters (AN/P600 effects) for the overall grammaticality effect. Further analysis revealed that the mean amplitude and distribution of the P600 effect was only significant in contexts where the S-V agreement violation occurred utterance-finally, regardless of type of agreement violation. The mean amplitude and distribution of the negativity did not differ significantly across types of agreement violation and utterance position. These findings suggest that the increased perceptual salience of the violation in utterance final position (due to phrase-final lengthening) influenced how S-V agreement violations were processed during sentence comprehension. Implications for the functional interpretation of language-related ERPs and experimental design are discussed. PMID:27625617

Effects of Type of Agreement Violation and Utterance Position on the Auditory Processing of Subject-Verb Agreement: An ERP Study.

PubMed

Dube, Sithembinkosi; Kung, Carmen; Peter, Varghese; Brock, Jon; Demuth, Katherine

2016-01-01

Previous ERP studies have often reported two ERP components-LAN and P600-in response to subject-verb (S-V) agreement violations (e.g., the boys (*) runs). However, the latency, amplitude and scalp distribution of these components have been shown to vary depending on various experiment-related factors. One factor that has not received attention is the extent to which the relative perceptual salience related to either the utterance position (verbal inflection in utterance-medial vs. utterance-final contexts) or the type of agreement violation (errors of omission vs. errors of commission) may influence the auditory processing of S-V agreement. The lack of reports on these effects in ERP studies may be due to the fact that most studies have used the visual modality, which does not reveal acoustic information. To address this gap, we used ERPs to measure the brain activity of Australian English-speaking adults while they listened to sentences in which the S-V agreement differed by type of agreement violation and utterance position. We observed early negative and positive clusters (AN/P600 effects) for the overall grammaticality effect. Further analysis revealed that the mean amplitude and distribution of the P600 effect was only significant in contexts where the S-V agreement violation occurred utterance-finally, regardless of type of agreement violation. The mean amplitude and distribution of the negativity did not differ significantly across types of agreement violation and utterance position. These findings suggest that the increased perceptual salience of the violation in utterance final position (due to phrase-final lengthening) influenced how S-V agreement violations were processed during sentence comprehension. Implications for the functional interpretation of language-related ERPs and experimental design are discussed.

Advancing methods for reliably assessing motivational interviewing fidelity using the Motivational Interviewing Skills Code

PubMed Central

Lord, Sarah Peregrine; Can, Doğan; Yi, Michael; Marin, Rebeca; Dunn, Christopher W.; Imel, Zac E.; Georgiou, Panayiotis; Narayanan, Shrikanth; Steyvers, Mark; Atkins, David C.

2014-01-01

The current paper presents novel methods for collecting MISC data and accurately assessing reliability of behavior codes at the level of the utterance. The MISC 2.1 was used to rate MI interviews from five randomized trials targeting alcohol and drug use. Sessions were coded at the utterance-level. Utterance-based coding reliability was estimated using three methods and compared to traditional reliability estimates of session tallies. Session-level reliability was generally higher compared to reliability using utterance-based codes, suggesting that typical methods for MISC reliability may be biased. These novel methods in MI fidelity data collection and reliability assessment provided rich data for therapist feedback and further analyses. Beyond implications for fidelity coding, utterance-level coding schemes may elucidate important elements in the counselor-client interaction that could inform theories of change and the practice of MI. PMID:25242192

Advancing methods for reliably assessing motivational interviewing fidelity using the motivational interviewing skills code.

PubMed

Lord, Sarah Peregrine; Can, Doğan; Yi, Michael; Marin, Rebeca; Dunn, Christopher W; Imel, Zac E; Georgiou, Panayiotis; Narayanan, Shrikanth; Steyvers, Mark; Atkins, David C

2015-02-01

The current paper presents novel methods for collecting MISC data and accurately assessing reliability of behavior codes at the level of the utterance. The MISC 2.1 was used to rate MI interviews from five randomized trials targeting alcohol and drug use. Sessions were coded at the utterance-level. Utterance-based coding reliability was estimated using three methods and compared to traditional reliability estimates of session tallies. Session-level reliability was generally higher compared to reliability using utterance-based codes, suggesting that typical methods for MISC reliability may be biased. These novel methods in MI fidelity data collection and reliability assessment provided rich data for therapist feedback and further analyses. Beyond implications for fidelity coding, utterance-level coding schemes may elucidate important elements in the counselor-client interaction that could inform theories of change and the practice of MI. Copyright © 2015 Elsevier Inc. All rights reserved.

Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.

PubMed

Eussen, Simone J P M; Vollset, Stein Emil; Igland, Jannicke; Meyer, Klaus; Fredriksen, Ase; Ueland, Per Magne; Jenab, Mazda; Slimani, Nadia; Boffetta, Paolo; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine; Morois, Sophie; Weikert, Cornelia; Pischon, Tobias; Linseisen, Jakob; Kaaks, Rudolf; Trichopoulou, Antonia; Zilis, Demosthenes; Katsoulis, Michael; Palli, Domenico; Berrino, Franco; Vineis, Paolo; Tumino, Rosario; Panico, Salvatore; Peeters, Petra H M; Bueno-de-Mesquita, H Bas; van Duijnhoven, Fränzel J B; Gram, Inger Torhild; Skeie, Guri; Lund, Eiliv; González, Carlos A; Martínez, Carmen; Dorronsoro, Miren; Ardanaz, Eva; Navarro, Carmen; Rodríguez, Laudina; Van Guelpen, Bethany; Palmqvist, Richard; Manjer, Jonas; Ericson, Ulrika; Bingham, Sheila; Khaw, Kay-Tee; Norat, Teresa; Riboli, Elio

2010-05-01

A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber. Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; Ptrend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C-->T, MTHFR1298A-->C, MTR2756A-->G, MTRR66A-->G, and MTHFD11958G-->A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC=1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC=0.74 (0.39-1.37); 0.34]. The SLC19A180G-->A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59); <0.01]. This large European prospective multicenter study did not show an association of CRC risk with plasma folate status nor with MTHFR polymorphisms. Findings of the present study tend to weaken the evidence that folate plays an important role in CRC carcinogenesis. However, larger sample sizes are needed to adequately address potential gene-environment interactions. Copyright (c) 2010 AACR

Using interactive voice response to improve disease management and compliance with acute coronary syndrome best practice guidelines: A randomized controlled trial.

PubMed

Sherrard, Heather; Duchesne, Lloyd; Wells, George; Kearns, Sharon Ann; Struthers, Christine

2015-01-01

There is evidence from large clinical trials that compliance with standardized best practice guidelines (BPGs) improves survival of acute coronary syndrome (ACS) patients. However, their application is often suboptimal. In this study, the researchers evaluated whether the use of an interactive voice response (IVR) follow-up system improved ACS BPG compliance. This was a single-centre randomized control trial (RCT) of 1,608 patients (IVR=803; usual care=805). The IVR group received five automated calls in 12 months. The primary composite outcome was increased medication compliance and decreased adverse events. A significant improvement of 60% in the IVR group for the primary composite outcome was found (RR 1.60, 95% CI: 1.29 to 2.00, p <0.001). There was significant improvement in medication compliance (p <0.001) and decrease in unplanned medical visits (p = 0.023). At one year, the majority of patients ( 85%) responded positively to using the system again. Follow-up by IVR produced positive outcomes in ACS patients.

Mothers' Attention-Getting Utterances during Shared Book Reading: Links to Low-Income Preschoolers' Verbal Engagement, Visual Attention, and Early Literacy

ERIC Educational Resources Information Center

Son, Seung-Hee Claire; Tineo, Maria F.

2016-01-01

This study examined associations among low-income mothers' use of attention-getting utterances during shared book reading, preschoolers' verbal engagement and visual attention to reading, and their early literacy skills (N = 51). Mother-child shared book reading sessions were videotaped and coded for each utterance, including attention talk,…

Mean Length of Utterance Levels in 6-Month Intervals for Children 3 to 9 Years with and without Language Impairments

ERIC Educational Resources Information Center

Rice, Mabel L.; Smolik, Filip; Perpich, Denise; Thompson, Travis; Rytting, Nathan; Blossom, Megan

2010-01-01

Purpose: The mean length of children's utterances is a valuable estimate of their early language acquisition. The available normative data lack documentation of language and nonverbal intelligence levels of the samples. This study reports age-referenced mean length of utterance (MLU) data from children with specific language impairment (SLI) and…

Emotional reactivity and regulation associated with fluent and stuttered utterances of preschool-age children who stutter

PubMed Central

Jones, Robin M.; Conture, Edward G.; Walden, Tedra A.

2014-01-01

Purpose The purpose of this study was to assess the relation between emotional reactivity and regulation associated with fluent and stuttered utterances of preschool-age children who stutter (CWS) and those who do not (CWNS). Participants Participants were eight 3 to 6-year old CWS and eight CWNS of comparable age and gender. Methods Participants were exposed to three emotion-inducing overheard conversations—neutral, angry and happy—and produced a narrative following each overheard conversation. From audio-video recordings of these narratives, coded behavioral analysis of participants’ negative and positive affect and emotion regulation associated with stuttered and fluent utterances was conducted. Results Results indicated that CWS were significantly more likely to exhibit emotion regulation attempts prior to and during their fluent utterances following the happy as compared to the negative condition, whereas CWNS displayed the opposite pattern. Within-group assessment indicated that CWS were significantly more likely to display negative emotion prior to and during their stuttered than fluent utterances, particularly following the positive overheard conversation. Conclusions After exposure to emotional-inducing overheard conversations, changes in preschool-age CWS’s emotion and emotion regulatory attempts were associated with the fluency of their utterances. PMID:24630144

The sounds of sarcasm in English and Cantonese: A cross-linguistic production and perception study

NASA Astrophysics Data System (ADS)

Cheang, Henry S.

Three studies were conducted to examine the acoustic markers of sarcasm in English and in Cantonese, and the manner in which such markers are perceived across these languages. The first study consisted of acoustic analyses of sarcastic utterances spoken in English to verify whether particular prosodic cues correspond to English sarcastic speech. Native English speakers produced utterances expressing sarcasm, sincerity, humour, or neutrality. Measures taken from each utterance included fundamental frequency (F0), amplitude, speech rate, harmonics-to-noise ratio (HNR, to probe voice quality), and one-third octave spectral values (to probe resonance). The second study was conducted to ascertain whether specific acoustic features marked sarcasm in Cantonese and how such features compare with English sarcastic prosody. The elicitation and acoustic analysis methods from the first study were applied to similarly-constructed Cantonese utterances spoken by native Cantonese speakers. Direct acoustic comparisons between Cantonese and English sarcasm exemplars were also made. To further test for cross-linguistic prosodic cues of sarcasm and to assess whether sarcasm could be conveyed across languages, a cross-linguistic perceptual study was then performed. A subset of utterances from the first two studies was presented to naive listeners fluent in either Cantonese or English. Listeners had to identify the attitude in each utterance regardless of language of presentation. Sarcastic utterances in English (regardless of text) were marked by lower mean F0 and reductions in HNR and F0 standard deviation (relative to comparison attitudes). Resonance changes, reductions in both speech rate and F0 range signalled sarcasm in conjunction with some vocabulary terms. By contrast, higher mean F0, amplitude range reductions, and F0 range restrictions corresponded with sarcastic utterances spoken in Cantonese regardless of text. For Cantonese, reduced speech rate and higher HNR interacted with certain vocabulary to mark sarcasm. Sarcastic prosody was most distinguished from acoustic features corresponding to sincere utterances in both languages. Direct English-Cantonese comparisons between sarcasm tokens confirmed cross-linguistic differences in sarcastic prosody. Finally, Cantonese and English listeners could identify sarcasm in their native languages but identified sarcastic utterances spoken in the unfamiliar language at chance levels. It was concluded that particular acoustic cues marked sarcastic speech in Cantonese and English, and these patterns of sarcastic prosody were specific to each language.

Children's Understanding That Utterances Emanate from Minds: Using Speaker Belief To Aid Interpretation.

ERIC Educational Resources Information Center

Mitchell, Peter; Robinson, Elizabeth J.; Thompson, Doreen E.

1999-01-01

Three experiments examined 3- to 6-year olds' ability to use a speaker's utterance based on false belief to identify which of several referents was intended. Found that many 4- to 5-year olds performed correctly only when it was unnecessary to consider the speaker's belief. When the speaker gave an ambiguous utterance, many 3- to 6-year olds…

Reasonable Language: An Integrative Study of Paul Grice's Theories of Meaning, Reasoning, and Value

ERIC Educational Resources Information Center

Kurle, BonnieJean

2012-01-01

Three worries seem to plague Grice's theory of meaning. If, as Grice seems to hold, utterer intentions, including the meaning intention (M-intention), are to be epistemically prior to what some utterance--what some sentence or phrase-means, then one should be able to translate utterances from a language radically different from one's…

How Do Children Acquire Early Grammar and Build Multiword Utterances? A Corpus Study of French Children Aged 2 to 4

ERIC Educational Resources Information Center

Le Normand, M. T.; Moreno-Torres, I.; Parisse, C.; Dellatolas, G.

2013-01-01

In the last 50 years, researchers have debated over the lexical or grammatical nature of children's early multiword utterances. Due to methodological limitations, the issue remains controversial. This corpus study explores the effect of grammatical, lexical, and pragmatic categories on mean length of utterances (MLU). A total of 312 speech samples…

Self-, other-, and joint monitoring using forward models.

PubMed

Pickering, Martin J; Garrod, Simon

2014-01-01

In the psychology of language, most accounts of self-monitoring assume that it is based on comprehension. Here we outline and develop the alternative account proposed by Pickering and Garrod (2013), in which speakers construct forward models of their upcoming utterances and compare them with the utterance as they produce them. We propose that speakers compute inverse models derived from the discrepancy (error) between the utterance and the predicted utterance and use that to modify their production command or (occasionally) begin anew. We then propose that comprehenders monitor other people's speech by simulating their utterances using covert imitation and forward models, and then comparing those forward models with what they hear. They use the discrepancy to compute inverse models and modify their representation of the speaker's production command, or realize that their representation is incorrect and may develop a new production command. We then discuss monitoring in dialogue, paying attention to sequential contributions, concurrent feedback, and the relationship between monitoring and alignment.

Self-, other-, and joint monitoring using forward models

PubMed Central

Pickering, Martin J.; Garrod, Simon

2014-01-01

In the psychology of language, most accounts of self-monitoring assume that it is based on comprehension. Here we outline and develop the alternative account proposed by Pickering and Garrod (2013), in which speakers construct forward models of their upcoming utterances and compare them with the utterance as they produce them. We propose that speakers compute inverse models derived from the discrepancy (error) between the utterance and the predicted utterance and use that to modify their production command or (occasionally) begin anew. We then propose that comprehenders monitor other people’s speech by simulating their utterances using covert imitation and forward models, and then comparing those forward models with what they hear. They use the discrepancy to compute inverse models and modify their representation of the speaker’s production command, or realize that their representation is incorrect and may develop a new production command. We then discuss monitoring in dialogue, paying attention to sequential contributions, concurrent feedback, and the relationship between monitoring and alignment. PMID:24723869

Lexical and Acoustic Features of Maternal Utterances Addressing Preverbal Infants in Picture Book Reading Link to 5-Year-Old Children's Language Development

ERIC Educational Resources Information Center

Liu, Huei-Mei

2014-01-01

Research Findings: I examined the long-term association between the lexical and acoustic features of maternal utterances during book reading and the language skills of infants and children. Maternal utterances were collected from 22 mother-child dyads in picture book-reading episodes when children were ages 6-12 months and 5 years. Two aspects of…

AC loss in YBCO coated conductors at high dB/dt measured using a spinning magnet calorimeter (stator testbed environment)

NASA Astrophysics Data System (ADS)

Murphy, J. P.; Gheorghiu, N. N.; Bullard, T.; Haugan, T.; Sumption, M. D.; Majoros, M.; Collings, E. W.

2017-09-01

A new facility for the measurement of AC loss in superconductors at high dB/dt has been developed. The test device has a spinning rotor consisting of permanent magnets arranged in a Halbach array; the sample, positioned outside of this, is exposed to a time varying AC field with a peak radial field of 0.566 T. At a rotor speed of 3600 RPM the frequency of the AC field is 240 Hz, the radial dB/dt is 543 T/s and the tangential dB/dt is 249 T/s. Loss is measured using nitrogen boiloff from a double wall calorimeter feeding a gas flow meter. The system is calibrated using power from a known resistor. YBCO tape losses were measured in the new device and compared to the results from a solenoidal magnet AC loss system measurement of the same samples (in this latter case measurements were limited to a field of amplitude 0.1 T and a dB/dt of 100 T/s). Solenoidal magnet system AC loss measurements taken on a YBCO sample agreed with the Brandt loss expression associated with a 0-0.1 T Ic of 128 A. Subsequently, losses for two more YBCO tapes nominally identical to the first were individually measured in this spinning magnet calorimeter (SMC) machine with a Bmax of 0.566 T and dB/dt of up to 272 T/s. The losses, compared to a simplified version of the Brandt expression, were consistent with the average Ic expected for the tape in the 0-0.5 T range at 77 K. The eddy current contribution was consistent with a 77 K residual resistance ratio, RR, of 4.0. The SMC results for these samples agreed to within 5%. Good agreement was also obtained between the results of the SMC AC loss measurement and the solenoidal magnet AC loss measurement on the same samples.

Changes of deceleration and acceleration capacity of heart rate in patients with acute hemispheric ischemic stroke.

PubMed

Xu, Yan-Hong; Wang, Xing-De; Yang, Jia-Jun; Zhou, Li; Pan, Yong-Chao

2016-01-01

Autonomic dysfunction is common after stroke, which is correlated with unfavorable outcome. Phase-rectified signal averaging is a newly developed technique for assessing cardiac autonomic function, by detecting sympathetic and vagal nerve activity separately through calculating acceleration capacity (AC) and deceleration capacity (DC) of heart rate. In this study, we used this technique for the first time to investigate the cardiac autonomic function of patients with acute hemispheric ischemic stroke. A 24-hour Holter monitoring was performed in 63 patients with first-ever acute ischemic stroke in hemisphere and sinus rhythm, as well as in 50 controls with high risk of stroke. DC, AC, heart rate variability parameters, standard deviation of all normal-to-normal intervals (SDNN), and square root of the mean of the sum of the squares of differences between adjacent normal-to-normal intervals (RMSSD) were calculated. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of stroke. We analyzed the changes of DC, AC, SDNN, and RMSSD and also studied the correlations between these parameters and NIHSS scores. The R-R (R wave to R wave on electrocardiogram) intervals, DC, AC, and SDNN in the cerebral infarction group were lower than those in controls (P=0.003, P=0.002, P=0.006, and P=0.043), but the difference of RMSSD and the D-value and ratio between absolute value of AC (|AC|) and DC were not statistically significant compared with those in controls. The DC of the infarction group was significantly correlated with |AC|, SDNN, and RMSSD (r=0.857, r=0.619, and r=0.358; P=0.000, P=0.000, and P=0.004). Correlation analysis also showed that DC, |AC|, and SDNN were negatively correlated with NIHSS scores (r=-0.279, r=-0.266, and r=-0.319; P=0.027, P=0.035, and P=0.011). Both DC and AC of heart rate decreased in patients with hemispheric infarction, reflecting a decrease in both vagal and sympathetic modulation. Both DC and AC were correlated with the severity of stroke.

A Nonlinear Fuel Optimal Reaction Jet Control Law

DTIC Science & Technology

2002-07-29

derive a nonlinear fuel optimal attitude control system (ACS) that drives the final state to the desired state according to a cost function that...αroll = 0.22 rad/s2 and αyaw = 0.20 rad/s2. [ ] ( )( )ωωτω rrr&r r&r ⋅×−⋅= ⋅Ω−= − 2 1 1 II QQ (9) where, Q r is the attitude quaternion ...from Table-1 regarding the relative performance of the nonlinear controller with a conventional PID controller ( used in this paper as a benchmark for

Stabilization of the Solvent Methyl-n-Amyl Ketone (MAK) in Vinyl Paints.

DTIC Science & Technology

1983-06-01

Europe 09757 Fort Carson 913 Chanute FS. IL 6188 Huntsville 35807 Fort Devens 01433 3345 CES/D. Stop 27 Lower MA SssSippi valley 39180 Fort O,’lb 13801...7th Army Training Comand 09114 Fort SherldA 60031 western Division 64066 87TN1: [TG-DEM 15) Fort Stewart 31313 ATTN Sr. Tnch. rAC -031 27332 40, 7tl...80903 ATTN: Facilities Engineer ATTN: OAEN- RR Fort Belvoir 22060 AITTN- 0AE-RCC Area Engineer ALDC-Area Office Fort Benning 3190S ATTN: DAEN-DM

How language production shapes language form and comprehension

PubMed Central

MacDonald, Maryellen C.

2012-01-01

Language production processes can provide insight into how language comprehension works and language typology—why languages tend to have certain characteristics more often than others. Drawing on work in memory retrieval, motor planning, and serial order in action planning, the Production-Distribution-Comprehension (PDC) account links work in the fields of language production, typology, and comprehension: (1) faced with substantial computational burdens of planning and producing utterances, language producers implicitly follow three biases in utterance planning that promote word order choices that reduce these burdens, thereby improving production fluency. (2) These choices, repeated over many utterances and individuals, shape the distributions of utterance forms in language. The claim that language form stems in large degree from producers' attempts to mitigate utterance planning difficulty is contrasted with alternative accounts in which form is driven by language use more broadly, language acquisition processes, or producers' attempts to create language forms that are easily understood by comprehenders. (3) Language perceivers implicitly learn the statistical regularities in their linguistic input, and they use this prior experience to guide comprehension of subsequent language. In particular, they learn to predict the sequential structure of linguistic signals, based on the statistics of previously-encountered input. Thus, key aspects of comprehension behavior are tied to lexico-syntactic statistics in the language, which in turn derive from utterance planning biases promoting production of comparatively easy utterance forms over more difficult ones. This approach contrasts with classic theories in which comprehension behaviors are attributed to innate design features of the language comprehension system and associated working memory. The PDC instead links basic features of comprehension to a different source: production processes that shape language form. PMID:23637689

Study of Discussion Record Analysis Using Temporal Data Crystallization and Its Application to TV Scene Analysis

DTIC Science & Technology

2015-03-31

analysis. For scene analysis, we use Temporal Data Crystallization (TDC), and for logical analysis, we use Speech Act theory and Toulmin Argumentation...utterance in the discussion record. (i) An utterance ID, and a speaker ID (ii) Speech acts (iii) Argument structure Speech act denotes...mediator is expected to use more OQs than CQs. When the speech act of an utterance is an argument, furthermore, we recognize the conclusion part

Beginning to Talk Like an Adult: Increases in Speech-like Utterances in Young Cochlear Implant Recipients and Toddlers with Normal Hearing

PubMed Central

Ertmer, David J.; Jung, Jongmin; Kloiber, Diana True

2013-01-01

Background Speech-like utterances containing rapidly combined consonants and vowels eventually dominate the prelinguistic and early word productions of toddlers who are developing typically (TD). It seems reasonable to expect a similar phenomenon in young cochlear implants (CI) recipients. This study sought to determine the number of months of robust hearing experience needed to achieve a majority of speech-like utterances in both of these groups. Methods Speech samples were recorded at 3-month intervals during the first 2 years of CI experience, and between 6- and 24 months of age in TD children. Speech-like utterances were operationally defined as those belonging to the Basic Canonical Syllables (BCS) or Advanced Forms (AF) levels of the Consolidated Stark Assessment of Early Vocal Development-Revised. Results On average, the CI group achieved a majority of speech- like utterances after 12 months, and the TD group after 18 months of robust hearing experience. The CI group produced greater percentages of speech-like utterances at each interval until 24-months, when both groups approximated 80%. Conclusion Auditory deprivation did not limit progress in vocal development as young CI recipients showed more-rapid-than-typical speech development during the first 2 years of device use. Implications for the Infraphonological model of speech development are considered. PMID:23813203

Everyday problem solving in African Americans and European Americans with Alzheimer's disease: an exploratory study.

PubMed

Ripich, Danielle N; Fritsch, Thomas; Ziol, Elaine

2002-03-01

In this exploratory study, we compared the performance of 10 African American and 26 European American persons with early- to mid-stage Alzheimer's disease (AD) to 20 nondemented elderly (NE), using a shortened version of the Test of Problem Solving (TOPS). The TOPS measures verbal reasoning to solve everyday problems in five areas: explaining inferences, determining causes, answering negative why questions, determining solutions, and avoiding problems. Six linguistic measures were also examined: total utterances, abandoned utterances, length of utterances, maze words, questions, and total words. NE performed better than AD subjects on all but one measure of verbal reasoning ability. AD subjects also showed a trend to use more total utterances and abandoned utterances than NE. For the AD group, no ethnic differences were found for verbal reasoning or linguistic measures. The findings from this preliminary investigation suggest that, compared to European Americans, African American persons with AD demonstrate similar everyday problem solving and linguistic skills. Thus, assessments such as TOPS that examine everyday problem solving may be a useful nonbiased evaluation tool for persons with AD in these two ethnic groups.

Tamoxifen for the management of breast events induced by non-steroidal antiandrogens in patients with prostate cancer: a systematic review

PubMed Central

2012-01-01

Background Tamoxifen has emerged as a potential management option for gynecomastia and breast pain due to non-steroidal antiandrogens, and it is considered an alternative to surgery or radiotherapy. The objective of this systematic review was to assess the benefits and harms of tamoxifen, in comparison to other treatment options, for either the prophylaxis or treatment of breast events induced by non-steroidal antiandrogens in prostate cancer patients. Methods We searched CENTRAL, MEDLINE, EMBASE, reference lists, the abstracts of three major conferences and three trial registers to identify ongoing randomized controlled trials (RCTs). Two authors independently screened the articles identified, assessed the trial quality and extracted data. The protocol was prospectively registered (CRD42011001320; http://www.crd.york.ac.uk/PROSPERO). Results Four studies were identified. Tamoxifen significantly reduced the risk of suffering from gynecomastia (risk ratio 9RR0 0.10, 95% CI 0.05 to 0.22) or breast pain (RR 0.06, 95% CI 0.02 to 0.17) at six months compared to untreated controls. Tamoxifen also showed a significant benefit for the prevention of gynecomastia (RR 0.22, 95% CI 0.08 to 0.58) and breast pain (RR 0.25, 95% CI 0.10 to 0.64) when compared to anastrozole after a median of 12 months. One study showed a significant benefit of tamoxifen for the prevention of gynecomastia (RR 0.24, 95% CI 0.09 to 0.65) and breast pain (RR 0.20, 95% CI 0.06 to 0.65) when compared with radiotherapy at six months. Radiotherapy increased the risk of suffering from nipple erythema and skin irritation, but there were no significant differences for any other adverse events (all P > 0.05). Conclusions The currently available evidence suggests good efficacy of tamoxifen for the prevention and treatment of breast events induced by non-steroidal antiandrogens. The impact of tamoxifen therapy on long-term adverse events, disease progression and survival remains unclear. Further large, well-designed RCTs, including long-term follow-ups, are warranted. Also, the optimal dose needs to be clarified. PMID:22925442

Analysis of Timing Control Mechanism of Utterance and Body Motion Using Dialogue between Human and Communication Robot

NASA Astrophysics Data System (ADS)

Takasugi, Shoji; Yamamoto, Tomohito; Muto, Yumiko; Abe, Hiroyuki; Miyake, Yoshihiro

The purpose of this study is to clarify the effects of timing control of utterance and body motion in human-robot interaction. Our previous study has already revealed the correlation of timing of utterance and body motion in human-human communication. Here we proposed a timing control model based on our previous research and estimated its influence to realize human-like communication using a questionnaire method. The results showed that the difference of effectiveness between the communication with the timing control model and that without it was observed. In addition, elderly people evaluated the communication with timing control much higher than younger people. These results show not only the importance of timing control of utterance and body motion in human communication but also its effectiveness for realizing human-like human-robot interaction.

Matching Speaking to Singing Voices and the Influence of Content.

PubMed

Peynircioğlu, Zehra F; Rabinovitz, Brian E; Repice, Juliana

2017-03-01

We tested whether speaking voices of unfamiliar people could be matched to their singing voices, and, if so, whether the content of the utterances would influence this matching performance. Our hypothesis was that enough acoustic features would remain the same between speaking and singing voices such that their identification as belonging to the same or different individuals would be possible even upon a single hearing. We also hypothesized that the contents of the utterances would influence this identification process such that voices uttering words would be easier to match than those uttering vowels. We used a within-participant design with blocked stimuli that were counterbalanced using a Latin square design. In one block, mode (speaking vs singing) was manipulated while content was held constant; in another block, content (word vs syllable) was manipulated while mode was held constant, and in the control block, both mode and content were held constant. Participants indicated whether the voices in any given pair of utterances belonged to the same person or to different people. Cross-mode matching was above chance level, although mode-congruent performance was better. Further, only speaking voices were easier to match when uttering words. We can identify speaking and singing voices as the same or different even on just a single hearing. However, content interacts with mode such that words benefit matching of speaking voices but not of singing voices. Results are discussed within an attentional framework. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

The Edge Factor in Early Word Segmentation: Utterance-Level Prosody Enables Word Form Extraction by 6-Month-Olds

PubMed Central

Johnson, Elizabeth K.; Seidl, Amanda; Tyler, Michael D.

2014-01-01

Past research has shown that English learners begin segmenting words from speech by 7.5 months of age. However, more recent research has begun to show that, in some situations, infants may exhibit rudimentary segmentation capabilities at an earlier age. Here, we report on four perceptual experiments and a corpus analysis further investigating the initial emergence of segmentation capabilities. In Experiments 1 and 2, 6-month-olds were familiarized with passages containing target words located either utterance medially or at utterance edges. Only those infants familiarized with passages containing target words aligned with utterance edges exhibited evidence of segmentation. In Experiments 3 and 4, 6-month-olds recognized familiarized words when they were presented in a new acoustically distinct voice (male rather than female), but not when they were presented in a phonologically altered manner (missing the initial segment). Finally, we report corpus analyses examining how often different word types occur at utterance boundaries in different registers. Our findings suggest that edge-aligned words likely play a key role in infants’ early segmentation attempts, and also converge with recent reports suggesting that 6-month-olds’ have already started building a rudimentary lexicon. PMID:24421892

Effects of Disfluency in Online Interpretation of Deception.

PubMed

Loy, Jia E; Rohde, Hannah; Corley, Martin

2017-05-01

A speaker's manner of delivery of an utterance can affect a listener's pragmatic interpretation of the message. Disfluencies (such as filled pauses) influence a listener's off-line assessment of whether the speaker is truthful or deceptive. Do listeners also form this assessment during the moment-by-moment processing of the linguistic message? Here we present two experiments that examined listeners' judgments of whether a speaker was indicating the true location of the prize in a game during fluent and disfluent utterances. Participants' eye and mouse movements were biased toward the location named by the speaker during fluent utterances, whereas the opposite bias was observed during disfluent utterances. This difference emerged rapidly after the onset of the critical noun. Participants were similarly sensitive to disfluencies at the start of the utterance (Experiment 1) and in the middle (Experiment 2). Our findings support recent research showing that listeners integrate pragmatic information alongside semantic content during the earliest moments of language processing. Unlike prior work which has focused on pragmatic effects in the interpretation of the literal message, here we highlight disfluency's role in guiding a listener to an alternative non-literal message. Copyright © 2016 Cognitive Science Society, Inc.

Audio steganography by amplitude or phase modification

NASA Astrophysics Data System (ADS)

Gopalan, Kaliappan; Wenndt, Stanley J.; Adams, Scott F.; Haddad, Darren M.

2003-06-01

This paper presents the results of embedding short covert message utterances on a host, or cover, utterance by modifying the phase or amplitude of perceptually masked or significant regions of the host. In the first method, the absolute phase at selected, perceptually masked frequency indices was changed to fixed, covert data-dependent values. Embedded bits were retrieved at the receiver from the phase at the selected frequency indices. Tests on embedding a GSM-coded covert utterance on clean and noisy host utterances showed no noticeable difference in the stego compared to the hosts in speech quality or spectrogram. A bit error rate of 2 out of 2800 was observed for a clean host utterance while no error occurred for a noisy host. In the second method, the absolute phase of 10 or fewer perceptually significant points in the host was set in accordance with covert data. This resulted in a stego with successful data retrieval and a slightly noticeable degradation in speech quality. Modifying the amplitude of perceptually significant points caused perceptible differences in the stego even with small changes of amplitude made at five points per frame. Finally, the stego obtained by altering the amplitude at perceptually masked points showed barely noticeable differences and excellent data recovery.

Sun River (24CA74): A Stratified Pelican Lake and Oxbow Occupation Site near Great Falls, Montana.

DTIC Science & Technology

1983-08-31

silicified sediment probably were derived from outcrops of the Madison and Kootenai Formations, respectively. BW Bade t -[ / ’,’V ~ St rr, ,’, T...8217 .404 10 A- ac. UW cc "a 0 141 v Sso 7-19 Figure 7-9. Level VI uniface tools (full scale): a: Tool #62, 45N 268W, basalt cortical flake b: Tool #49, 43N...frcxm the Madison Group of Mississippian age, which occurs widely in central Montana, especially in the Little Belt Mountains. All of these materials also

National Program for Inspection of Non-Federal Dams. Shenipsit Dam (CT 00482), Thames River Basin, Stafford, Connecticut. Phase I Inspection Report.

DTIC Science & Technology

1980-09-01

purpose of a Phase I Investigation is to identify expeditiously - those dams which may pose hazards to human life or property. The assessment of the general...calculatec by the Soil Loss Formula (0.1 ton/ac/yr. y±cld). The dosianed heiGht of the structures vill provide st rage for a 50 year sediment...As shown in the above listing the design meet, the c:rr,1 ,ia established in all instances. L B-13 rage -,- n We have discussed with the S. C.S

F-16 Pilot Media Selection

DTIC Science & Technology

1981-03-01

sweep wLS1vaTI GrJAVA-M*- .~--- ’- - - -t------ 7EOA FFM 𔃼t ee.W?mv ~.L: 1.7.5.4/2n C.AMM~AT!: L’sftle MIMI I-- itlm . z4 ~~~as~e;.~~ i c’.1~te1...ac~e I C-s.met~ I £’A.F- ivsa ~ta I ~ acca az~Y I I tc~ ~t I tca± - e~aec N .x-c, ; cnar. ~ ;zar~a I ~i~; EC~I~ a c2r..1C:%ttI I ~t7!fl - -- rr..r

IMUX: Managing Tor Connections from Two to Infinity, and Beyond

DTIC Science & Technology

2014-11-03

generalizes between the “per-circuit” approaches such as PCTCP and the fixed number of sessions in “ vanilla Tor” (1) and Torchestra (2). • We analyze a variety...increasing performance. The two main components of the algo- rithm are global scheduling and autotuning. In vanilla Tor, libevent iterates through the...1 2 3 4 5 Download Time (s) 0.0 0.2 0.4 0.6 0.8 1.0 C um ul at iv e Fr ac tio n vanilla imux-rr imux-ewma imux-shortest (a) Time to first byte 0 2 4

Pharmacologic intervention for retained placenta: a systematic review and meta-analysis.

PubMed

Duffy, James M N; Mylan, Sophie; Showell, Marian; Wilson, Matthew J A; Khan, Khalid S

2015-03-01

To assess the effectiveness and safety of pharmacologic interventions for the treatment of retained placenta (when the placenta remains undelivered after 30 minutes of active management of the third stage of labor). We searched: 1) Cochrane Central Register of Controlled Trials (CENTRAL), 2) Cochrane Pregnancy and Childbirth Group's Trials Register, 3) EMBASE, and 4) MEDLINE from inception to June 2014. Randomized controlled trials comparing a pharmacologic intervention(s) with a placebo for the treatment of retained placenta were included. Sixteen randomized controlled trials, including 1,683 participants, were included. Study characteristics and quality were recorded. The meta-analysis was based on random-effects methods for pooled data. There were no statistically significant differences in the requirement to perform manual removal of a placenta in patients treated with oxytocin (55% compared with 60%; relative risk [RR] 0.86, 95% confidence interval [CI] 0.73-1.02; 10 randomized controlled trials [RCTs]), prostaglandins (44% compared with 55%; RR 0.82, 95% CI 0.58-1.15; four RCTs), nitroglycerin (85% compared with 80%; RR 1.06, 95% CI 0.80-1.41; one RCT), or oxytocin and nitroglycerin (52% compared with 79%; RR 0.23, 95% CI 0.01-8.48; two RCTs) compared with placebo. There was limited reporting of secondary outcomes. As opposed to the use of oxytocin as part of the active management of the third stage of labor that has been shown to diminish bleeding in the third stage, once the diagnosis of retained placenta has been made, no pharmacologic treatment has been shown to be effective. When retained placenta is diagnosed, immediate manual removal of the placenta should be considered. PROSPERO International Prospective Register of Systematic Reviews, http://www.crd.york.ac.uk/PROSPERO/, CRD42014010641.

Physiological and production response of dairy goats bred in a tropical climate.

PubMed

de Souza, Priscila Teixeira; Salles, Maria Gorete Flores; da Costa, Antônio Nélson Lima; Carneiro, Hilton Alexandre Vidal; de Souza, Leonardo Peres; Rondina, Davide; de Araújo, Airton Alencar

2014-09-01

The aim of this work was to determine the adaptability of Saanen and ½Saanen × ½Anglo-Nubian (½S½AN) goats bred in tropical climates. The study included 30 goats, 15 Saanen and 15 ½S½AN. The data was collected during the rainy and dry seasons. During the whole experimental period, the environment variables were recorded, as well as rectal temperature (RT), superficial temperature (ST), respiratory rate (RR) and heart rate (HR) and milk production (MP). The adaptability coefficient (AC) was calculated for both genotypes. The averages were evaluated by ANOVA at 5% probability. There was a genotype and period of year effect, as well as the interaction genotype × period of year. Pearson's simple correlation analysis was then carried out between milk production and physiological and environment variables. There was a statistical difference (p < 0.05) between the seasons for RT, ST and RR. RT, RR and HR were lower for ½S½AN than Saanen goats, regardless of the season. MP was greater in the dry season (p < 0.05) (2.52 ± 0.50 kg/day for ½S½AN and 2.41 ± 0.38 kg/day for Saanen) than the rainy season (2.17 ± 0.27 kg/day for ½S½AN and 2.28 ± 0.53 kg/day for Saanen). The MP correlations were very significant (p < 0.05), however low and negative, where it was higher when correlated with RR in Saanen goats. Under the conditions of the present study, it is concluded that the goats were influenced by climatic factors, where the rainy period was more likely to cause thermal stress in the animals.

Physiological and production response of dairy goats bred in a tropical climate

NASA Astrophysics Data System (ADS)

de Souza, Priscila Teixeira; Salles, Maria Gorete Flores; da Costa, Antônio Nélson Lima; Carneiro, Hilton Alexandre Vidal; de Souza, Leonardo Peres; Rondina, Davide; de Araújo, Airton Alencar

2014-09-01

The aim of this work was to determine the adaptability of Saanen and ½Saanen × ½Anglo-Nubian (½S½AN) goats bred in tropical climates. The study included 30 goats, 15 Saanen and 15 ½S½AN. The data was collected during the rainy and dry seasons. During the whole experimental period, the environment variables were recorded, as well as rectal temperature (RT), superficial temperature (ST), respiratory rate (RR) and heart rate (HR) and milk production (MP). The adaptability coefficient (AC) was calculated for both genotypes. The averages were evaluated by ANOVA at 5 % probability. There was a genotype and period of year effect, as well as the interaction genotype × period of year. Pearson's simple correlation analysis was then carried out between milk production and physiological and environment variables. There was a statistical difference ( p < 0.05) between the seasons for RT, ST and RR. RT, RR and HR were lower for ½S½AN than Saanen goats, regardless of the season. MP was greater in the dry season ( p < 0.05) (2.52 ± 0.50 kg/day for ½S½AN and 2.41 ± 0.38 kg/day for Saanen) than the rainy season (2.17 ± 0.27 kg/day for ½S½AN and 2.28 ± 0.53 kg/day for Saanen). The MP correlations were very significant ( p < 0.05), however low and negative, where it was higher when correlated with RR in Saanen goats. Under the conditions of the present study, it is concluded that the goats were influenced by climatic factors, where the rainy period was more likely to cause thermal stress in the animals.

[Influence of human personal features on acoustic correlates of speech emotional intonation characteristics].

PubMed

Dmitrieva, E S; Gel'man, V Ia; Zaĭtseva, K A; Orlov, A M

2009-01-01

Comparative study of acoustic correlates of emotional intonation was conducted on two types of speech material: sensible speech utterances and short meaningless words. The corpus of speech signals of different emotional intonations (happy, angry, frightened, sad and neutral) was created using the actor's method of simulation of emotions. Native Russian 20-70-year-old speakers (both professional actors and non-actors) participated in the study. In the corpus, the following characteristics were analyzed: mean values and standard deviations of the power, fundamental frequency, frequencies of the first and second formants, and utterance duration. Comparison of each emotional intonation with "neutral" utterances showed the greatest deviations of the fundamental frequency and frequencies of the first formant. The direction of these deviations was independent of the semantic content of speech utterance and its duration, age, gender, and being actor or non-actor, though the personal features of the speakers affected the absolute values of these frequencies.

Don't Underestimate the Benefits of Being Misunderstood.

PubMed

Gibson, Edward; Tan, Caitlin; Futrell, Richard; Mahowald, Kyle; Konieczny, Lars; Hemforth, Barbara; Fedorenko, Evelina

2017-06-01

Being a nonnative speaker of a language poses challenges. Individuals often feel embarrassed by the errors they make when talking in their second language. However, here we report an advantage of being a nonnative speaker: Native speakers give foreign-accented speakers the benefit of the doubt when interpreting their utterances; as a result, apparently implausible utterances are more likely to be interpreted in a plausible way when delivered in a foreign than in a native accent. Across three replicated experiments, we demonstrated that native English speakers are more likely to interpret implausible utterances, such as "the mother gave the candle the daughter," as similar plausible utterances ("the mother gave the candle to the daughter") when the speaker has a foreign accent. This result follows from the general model of language interpretation in a noisy channel, under the hypothesis that listeners assume a higher error rate in foreign-accented than in nonaccented speech.

Using the self-select paradigm to delineate the nature of speech motor programming.

PubMed

Wright, David L; Robin, Don A; Rhee, Jooyhun; Vaculin, Amber; Jacks, Adam; Guenther, Frank H; Fox, Peter T

2009-06-01

The authors examined the involvement of 2 speech motor programming processes identified by S. T. Klapp (1995, 2003) during the articulation of utterances differing in syllable and sequence complexity. According to S. T. Klapp, 1 process, INT, resolves the demands of the programmed unit, whereas a second process, SEQ, oversees the serial order demands of longer sequences. A modified reaction time paradigm was used to assess INT and SEQ demands. Specifically, syllable complexity was dependent on syllable structure, whereas sequence complexity involved either repeated or unique syllabi within an utterance. INT execution was slowed when articulating single syllables in the form CCCV compared to simpler CV syllables. Planning unique syllables within a multisyllabic utterance rather than repetitions of the same syllable slowed INT but not SEQ. The INT speech motor programming process, important for mental syllabary access, is sensitive to changes in both syllable structure and the number of unique syllables in an utterance.

Semiotic diversity in utterance production and the concept of ‘language’

PubMed Central

Kendon, Adam

2014-01-01

Sign language descriptions that use an analytic model borrowed from spoken language structural linguistics have proved to be not fully appropriate. Pictorial and action-like modes of expression are integral to how signed utterances are constructed and to how they work. However, observation shows that speakers likewise use kinesic and vocal expressions that are not accommodated by spoken language structural linguistic models, including pictorial and action-like modes of expression. These, also, are integral to how speaker utterances in face-to-face interaction are constructed and to how they work. Accordingly, the object of linguistic inquiry should be revised, so that it comprises not only an account of the formal abstract systems that utterances make use of, but also an account of how the semiotically diverse resources that all languaging individuals use are organized in relation to one another. Both language as an abstract system and languaging should be the concern of linguistics. PMID:25092661

[Observation of oral actions using digital image processing system].

PubMed

Ichikawa, T; Komoda, J; Horiuchi, M; Ichiba, H; Hada, M; Matsumoto, N

1990-04-01

A new digital image processing system to observe oral actions is proposed. The system provides analyses of motion pictures along with other physiological signals. The major components are a video tape recorder, a digital image processor, a percept scope, a CCD camera, an A/D converter and a personal computer. Five reference points were marked on the lip and eyeglasses of 9 adult subjects. Lip movements were recorded and analyzed using the system when uttering five vowels and [ka, sa, ta, ha, ra, ma, pa, ba[. 1. Positions of the lip when uttering five vowels were clearly classified. 2. Active articulatory movements of the lip were not recognized when uttering consonants [k, s, t, h, r[. It seemed lip movements were dependent on tongue and mandibular movements. Downward and rearward movements of the upper lip, and upward and forward movements of the lower lip were observed when uttering consonants [m, p, b[.

An harmonic smile resulted from the use of ceramic prosthesis with zirconia structure: a case report.

PubMed

Tavarez, Rudys Rodolfo de Jesus; Goncalves, Leticia Machado; Dias, Ana Paula; Dias, Anna Claudia Pereira; Malheiros, Adriana Santos; Silva, Alice Carvalho; Bandeca, Matheus Coelho

2014-06-01

The rehabilitation of patients requiring an esthetic smile demands a multidisciplinary approach. This clinical report describes a treatment plan for recovery aesthetics' smile of anterior teeth using ceramic prosthesis with zirconia structure. Initially, a review of aesthetic parameters, diagnostic waxing, mock-up and provisional restorations was performed. A contextual assessment of aesthetic, proportion and shape of teeth was done to recreate a natural looking for teeth in consonance with the smile line. Subsequently, based on these parameters, fixed prostheses of the upper anterior teeth using ceramic restorations with zirconia infrastructures were performed. The use of ceramic restorations with zirconia structures associated with a careful treatment plan allows the professional to integrate esthetic and function for satisfactory clinical results. How to cite the article: Tavarez RR, Gonçalves LM, Dias AP, Dias AC, Malheiros AS, Silva AC, Bandeca MC. An harmonic smile resulted from the use of ceramic prosthesis with zirconia structure: A case report. J Int Oral Health 2014;6(3):90-2.

CC genotype of anti-apoptotic gene BCL-2 (-938 C/A) is an independent prognostic marker of unfavorable clinical outcome in patients with non-small-cell lung cancer.

PubMed

Javid, J; Mir, R; Mirza, M; Imtiyaz, A; Prasant, Y; Mariyam, Z; Julka, P K; Mohan, A; Lone, M; Ray, P C; Saxena, A

2015-04-01

B cell lymphoma 2 (BCL-2) gene is a well-known regulator of apoptosis and a key element in cancer development and progression. A regulatory (-938C>A, rs2279115) single-nucleotide polymorphism in the inhibitory P2 BCL-2 gene promoter generates significantly different BCL-2 promoter activities and has been associated with different clinical outcomes in various malignancies. The aim of the present study was to analyze the possible influence of the (-938C>A) SNP on the risk and survival of Indian patients suffering from NSCLC. A hospital-based case-control study of 155 age- and sex-matched patients diagnosed with NSCLC and 155 cancer-free controls was conducted and genotyped by performing PIRA-PCR to elucidate the putative association between clinical outcome and genotypes of BCL-2 (-938C>A, rs2279115). The association of the polymorphism with the survival of NSCLC patients was analyzed by Kaplan-Meier curves. In Indian NSCLC, patients increased risk of developing NSCLC was found to be associated with BCL-2 (-938) CC genotype, [OR 3.68 (1.92-6.79), RR 1.87 (1.35-2.57) and RD 31.03 (16.79-45.27) p 0.00006 for CC and OR 2.08 (1.18-3.66), RR 1.36 (1.08-1.71) and RD 17.74 (4.68-30.81) p 0.01 for AC genotype]. Patients homozygous for C allele exhibited a significant poor overall survival compared with patients displaying AC + CC or AC or AA genotype [median survival (months) 8 vs. 11 vs. 14 vs. 35.5 (p < 0.0001)]. In addition, significant associations were observed between TNM stage, histological type, distant metastases status, family history of any cancer, gender and age group of NSCLC patients with BCL-2 (-938C>A) polymorphism. Genetic polymorphism in the inhibitory P2 promoter region of anti-apoptotic BCL-2 genes contributes to the risk of developing non-small-cell lung cancer in Indian population. BCL-2 (-938CC) genotype was an independent adverse prognostic factor for patients with NSCLC.

A theoretical and methodological proposal for the descriptive assessment of therapeutic interactions.

PubMed

Froján-Parga, María Xesús; Ruiz-Sancho, Elena M; Calero-Elvira, Ana

2016-01-01

The goal of this study is to show the development of a strategy for a descriptive assessment of the therapeutic interaction. In this study, we develop an observational methodology to analyze the dialogues that took place during 92 sessions conducted in a psychological center in Madrid, Spain, in which 19 adults were treated for various psychological problems by 9 behavioral therapists. A system was developed to codify vocal behavior of both the therapists and the clients; the software The Observer XT was used for recording. Therapeutic interactions were analyzed using sequential analysis. There are three main sequences that synthesize the therapist-client interaction: first, an utterance by the client preceded by a therapist's verbalization, specifically a question (discriminative morphology) and followed by an expression of approval (reinforcement morphology); second, verbalizations of failure or discomfort uttered by the client, followed most often by verbalizations of disapproval (punishing morphology) uttered by the therapist; and third, verbalizations uttered by the client that are discriminated by the therapist after an in-depth explanation and followed by different therapist's utterances (expressions of approval, technical information, etc.). Depending on how the client responds the results in this study present a starting point for the study of the functional sequences that form the basis of therapeutic change.

On the intonation of German intonation questions: the role of the prenuclear region.

PubMed

Petrone, Caterina; Niebuhr, Oliver

2014-03-01

German questions and statements are distinguished not only by lexical and syntactic but also by intonational means. This study revisits, for Northern Standard German, how questions are signalled intonationally in utterances that have neither lexical nor syntactic cues. Starting from natural productions of such 'intonation questions', two perception experiments were run. Experiment 1 is based on a gating paradigm, which was applied to naturally produced questions and statements. Experiment 11 includes two indirect-identification tasks. Resynthesized stimuli were judged in relation to two context utterances, each of which was compatible with only one sentence mode interpretation. Results show that utterances with a finally falling nuclear pitch-accent contour can also trigger question perception. An utterance-final rise is not mandatory. Also, question and statement cues are not restricted to the intonational nucleus. Rather, listeners can refer to shape, slope, and alignment differences of the preceding prenuclear pitch accent to identify sentence mode. These findings are in line with studies suggesting that the utterance-final rise versus fall contrast is not directly related to sentence modality, but represents a separate attitudinal meaning dimension. Moreover, the findings support that both prenuclear and nuclear fundamental frequency (F0) patterns must be taken into account in the analysis of tune meaning.

Imitative Production of Rising Speech Intonation in Pediatric Cochlear Implant Recipients

PubMed Central

Peng, Shu-Chen; Tomblin, J. Bruce; Spencer, Linda J.; Hurtig, Richard R.

2011-01-01

Purpose This study investigated the acoustic characteristics of pediatric cochlear implant (CI) recipients' imitative production of rising speech intonation, in relation to the perceptual judgments by listeners with normal hearing (NH). Method Recordings of a yes–no interrogative utterance imitated by 24 prelingually deafened children with a CI were extracted from annual evaluation sessions. These utterances were perceptually judged by adult NH listeners in regard with intonation contour type (non-rise, partial-rise, or full-rise) and contour appropriateness (on a 5-point scale). Fundamental frequency, intensity, and duration properties of each utterance were also acoustically analyzed. Results Adult NH listeners' judgments of intonation contour type and contour appropriateness for each CI participant 's utterances were highly positively correlated. The pediatric CI recipients did not consistently use appropriate intonation contours when imitating a yes–no question. Acoustic properties of speech intonation produced by these individuals were discernible among utterances of different intonation contour types according to NH listeners' perceptual judgments. Conclusions These findings delineated the perceptual and acoustic characteristics of speech intonation imitated by prelingually deafened children and young adults with a CI. Future studies should address whether the degraded signals these individuals perceive via a CI contribute to their difficulties with speech intonation production. PMID:17905907

Visual Grouping in Accordance With Utterance Planning Facilitates Speech Production.

PubMed

Zhao, Liming; Paterson, Kevin B; Bai, Xuejun

2018-01-01

Research on language production has focused on the process of utterance planning and involved studying the synchronization between visual gaze and the production of sentences that refer to objects in the immediate visual environment. However, it remains unclear how the visual grouping of these objects might influence this process. To shed light on this issue, the present research examined the effects of the visual grouping of objects in a visual display on utterance planning in two experiments. Participants produced utterances of the form "The snail and the necklace are above/below/on the left/right side of the toothbrush" for objects containing these referents (e.g., a snail, a necklace and a toothbrush). These objects were grouped using classic Gestalt principles of color similarity (Experiment 1) and common region (Experiment 2) so that the induced perceptual grouping was congruent or incongruent with the required phrasal organization. The results showed that speech onset latencies were shorter in congruent than incongruent conditions. The findings therefore reveal that the congruency between the visual grouping of referents and the required phrasal organization can influence speech production. Such findings suggest that, when language is produced in a visual context, speakers make use of both visual and linguistic cues to plan utterances.

Eye’m talking to you: speakers’ gaze direction modulates co-speech gesture processing in the right MTG

PubMed Central

Toni, Ivan; Hagoort, Peter; Kelly, Spencer D.; Özyürek, Aslı

2015-01-01

Recipients process information from speech and co-speech gestures, but it is currently unknown how this processing is influenced by the presence of other important social cues, especially gaze direction, a marker of communicative intent. Such cues may modulate neural activity in regions associated either with the processing of ostensive cues, such as eye gaze, or with the processing of semantic information, provided by speech and gesture. Participants were scanned (fMRI) while taking part in triadic communication involving two recipients and a speaker. The speaker uttered sentences that were and were not accompanied by complementary iconic gestures. Crucially, the speaker alternated her gaze direction, thus creating two recipient roles: addressed (direct gaze) vs unaddressed (averted gaze) recipient. The comprehension of Speech&Gesture relative to SpeechOnly utterances recruited middle occipital, middle temporal and inferior frontal gyri, bilaterally. The calcarine sulcus and posterior cingulate cortex were sensitive to differences between direct and averted gaze. Most importantly, Speech&Gesture utterances, but not SpeechOnly utterances, produced additional activity in the right middle temporal gyrus when participants were addressed. Marking communicative intent with gaze direction modulates the processing of speech–gesture utterances in cerebral areas typically associated with the semantic processing of multi-modal communicative acts. PMID:24652857

Musical and linguistic listening modes in the speech-to-song illusion bias timing perception and absolute pitch memory.

PubMed

Graber, Emily; Simchy-Gross, Rhimmon; Margulis, Elizabeth Hellmuth

2017-12-01

The speech-to-song (STS) illusion is a phenomenon in which some spoken utterances perceptually transform to song after repetition [Deutsch, Henthorn, and Lapidis (2011). J. Acoust. Soc. Am. 129, 2245-2252]. Tierney, Dick, Deutsch, and Sereno [(2013). Cereb. Cortex. 23, 249-254] developed a set of stimuli where half tend to transform to perceived song with repetition and half do not. Those that transform and those that do not can be understood to induce a musical or linguistic mode of listening, respectively. By comparing performance on perceptual tasks related to transforming and non-transforming utterances, the current study examines whether the musical mode of listening entails higher sensitivity to temporal regularity and better absolute pitch (AP) memory compared to the linguistic mode. In experiment 1, inter-stimulus intervals within STS trials were steady, slightly variable, or highly variable. Participants reported how temporally regular utterance entrances were. In experiment 2, participants performed an AP memory task after a blocked STS exposure phase. Utterances identically matching those used in the exposure phase were targets among transposed distractors in the test phase. Results indicate that listeners exhibit heightened awareness of temporal manipulations but reduced awareness of AP manipulations to transforming utterances. This methodology establishes a framework for implicitly differentiating musical from linguistic perception.

[A study of the phenomenon of voice intonation: analysis, usage and diagnosis].

PubMed

Kazanecka, E; Pawłowski, Z; Zółtowski, M

1997-01-01

The aim of this work was to study the average rise time (RT) and average flow rate (MRT) in utterance. Data were collected from 48 singers and 44 patients. The group of patients included cases of modulus vocale, polypus laryngis, paresis bilateralis, hemiparesis, and CA laryngis. Various characteristics of utterance were recorded synchronously: the frequency and intensity of the fundamental laryngeal tone were measured with a laryngophone, a microphone was used to monitor acoustic radiation from the mouth, and a pneumotrachometer was applied for the measurement of flow rate. The data were stored and analysed with the use of a computer. Results show that the analysis carried out in the study describes the distinctive characteristics of normal and pathologic utterance. The main findings are as follows: a) rise time (RT) decreases with increasing loudness and pitch of the sound and is also shorter in staccato than inlegato sounds; b) during the initial transient of staccato sounds, the average flow rate in the glottis increases with intensity and pitch of the sound; c) pre-fonation time (TPP) and air volume do not differentiate normal and pathologic utterance; d) in cases of voice pathology, the analysis of utterance described in this study can be used for the evaluation of therapy and rehabilitation.

Language acquisition: hesitations in the question/answer dialogic pair.

PubMed

Chacon, Lourenço; Villega, Cristyane de Camargo Sampaio

2015-01-01

(1) To verify the existence (or not) of hesitation marks in the beginning of utterances in children's discourse; and (2) to determine to what extent the presence/absence of these marks could be explained by retrievable facts in the production conditions of their discourses. Interview situations with four children aged 5-6 years attending Kindergarten level II in a public preschool at the time of the data collection were analyzed. The interviews were recorded on audio and video, inside a soundproof booth, with high fidelity equipment. Afterwards, the recordings were transcribed by six transcribers that were specially trained for this task. Transcription rules that prioritized the analyses of hesitations were used. For the analysis of retrievable facts in the production conditions of children's discourse, the dialogic pair question-answer was adopted. A correlation between presence/absence of hesitation in the beginning of utterances in children and type of question (open/closed) made by the collocutor was observed. When the question was closed ended, the utterances were preferably initiated without hesitation marks, and when the question was open ended, the utterances were preferably initiated with hesitation marks. The presence/absence of hesitation marks in the beginning of utterances in children was found to be dependent on the production conditions of their discourses.

Young children's recall and reconstruction of audio and audiovisual narratives.

PubMed

Gibbons, J; Anderson, D R; Smith, R; Field, D E; Fischer, C

1986-08-01

It has been claimed that the visual component of audiovisual media dominates young children's cognitive processing. This experiment examines the effects of input modality while controlling the complexity of the visual and auditory content and while varying the comprehension task (recall vs. reconstruction). 4- and 7-year-olds were presented brief stories through either audio or audiovisual media. The audio version consisted of narrated character actions and character utterances. The narrated actions were matched to the utterances on the basis of length and propositional complexity. The audiovisual version depicted the actions visually by means of stop animation instead of by auditory narrative statements. The character utterances were the same in both versions. Audiovisual input produced superior performance on explicit information in the 4-year-olds and produced more inferences at both ages. Because performance on utterances was superior in the audiovisual condition as compared to the audio condition, there was no evidence that visual input inhibits processing of auditory information. Actions were more likely to be produced by the younger children than utterances, regardless of input medium, indicating that prior findings of visual dominance may have been due to the salience of narrative action. Reconstruction, as compared to recall, produced superior depiction of actions at both ages as well as more constrained relevant inferences and narrative conventions.

Health risk among asbestos cement sheet manufacturing workers in Thailand.

PubMed

Phanprasit, Wantanee; Sujirarat, Dusit; Chaikittiporn, Chalermchai

2009-12-01

To assess asbestos exposure and calculate the relative risks of lung cancer among asbestos cement roof sheet workers and to predict the incidence rate of lung cancer caused by asbestos in Thailand. A cross-sectional study was conducted in four asbestos cement roof factories. Both area and personal air samples were collected and analyzed employing NIOSH method # 7400 and counting rule A for all procesess and activities. The time weight average exposures were calculated for each studied task using average area concentrations of the mill and personal concentrations. Then, cumulative exposures were estimated based on the past nation-wide air sampling concentrations and those from the present study. The relative risk (RR) of lung cancer among asbestos cement sheet workers was calculated and the number of asbestos related lung cancer case was estimated. The roof fitting polishers had the highest exposure to airborne asbestos fiber (0.73 fiber/ml). The highest average area concentration was at the conveyor to the de-bagger areas (0.02 fiber/ml). The estimated cumulative exposure for the workers performed studied-tasks ranged in between 90.13-115.65 fiber-years/ml while the relative risk of lung cancer calculated using US. EPA's model were 5.37-5.96. Based on the obtained RR, lung cancer among AC sheet in Thailand would be 2 case/year. In case that AC sheet will not be prohibited from being manufactured, even though only chrysotile is allowed, the surveillance system should be further developed and more seriously implemented. The better control measures for all processes must be implemented. Furthermore, due to the environmental persistence of asbestos fiber, its life cycle analysis should be conducted in order to control environmental exposure of general population.

A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome

PubMed Central

Dong, Ming; Liao, James K.; Yan, Bryan; Li, Ruijie; Zhang, Mang; Yu, Cheuk-Man

2013-01-01

Background Recent experimental evidence suggests that the Rho/Rho-kinase (ROCK) system may play an important role in the pathogenesis of acute coronary syndrome (ACS) but there are little clinical data. This study examined if ROCK activity is increased in patients with acute coronary syndrome and if ROCK activity predicts long-term cardiovascular event. Method Blood samples were collected from 188 patients within 12 h after admission for ACS (53% men; aged 70±13) and from 61 control subject. The main outcome measures were all cause mortality, readmission with ACS or congestive heart failure (CHF) from presentation within around 2 years (mean:14.4±7.2 months; range: 0.5 to 26 months). Results ROCK activity increased in ST elevation myocardial infarction (STEMI, n=90) (3.33±0.93), non-STEMI (NSTEMI, n=68) (3.37±1.04) and unstable angina (UA, n=30) (2.53±0.59) groups when compared with disease controls (n=31) (2.06±0.38, all p<0.001) and healthy controls (n=30) (1.54±0.43, all p<0.001). There were 24 deaths, 34 readmissions with ACS and 15 admissions with CHF within 2 years. Patients with a high N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high ROCK activity on admission had a five-fold risk of a cardiovascular event (RR: 5.156; 95% CI: 2.180–12.191) when compared to those with low NT-proBNP and low ROCK activity. Conclusion ROCK activity was increased in patients with ACS, particularly in those with myocardial infarction. The combined usage of both ROCK activity and NT-proBNP might identify a subset of ACS patients at particularly high risk. PMID:22921817

Intelligibility and Individual Learner Differences in the EIL Context

ERIC Educational Resources Information Center

Matsuura, Hiroko

2007-01-01

According to Smith and Nelson [Smith, L.E., Nelson, C.E., 1985. "International intelligibility of English: directions and resources." "World Englishes" 3, 333-342.], "intelligibility" refers to word/utterance recognition, whereas "comprehensibility" is the understanding of word/utterance meaning. This study…

Terminating Devices in Spoken French.

ERIC Educational Resources Information Center

Andrews, Barry J.

1989-01-01

A study examines the way in which one group of discourse connectors, terminators, function in contemporary spoken French. Three types of terminators, elements used at the end of an utterance or section to indicate its completion, are investigated, including utterance terminators, interrogative tags, and terminal tags. (Author/MSE)

Brain basis of communicative actions in language

PubMed Central

Egorova, Natalia; Shtyrov, Yury; Pulvermüller, Friedemann

2016-01-01

Although language is a key tool for communication in social interaction, most studies in the neuroscience of language have focused on language structures such as words and sentences. Here, the neural correlates of speech acts, that is, the actions performed by using language, were investigated with functional magnetic resonance imaging (fMRI). Participants were shown videos, in which the same critical utterances were used in different communicative contexts, to Name objects, or to Request them from communication partners. Understanding of critical utterances as Requests was accompanied by activation in bilateral premotor, left inferior frontal and temporo-parietal cortical areas known to support action-related and social interactive knowledge. Naming, however, activated the left angular gyrus implicated in linking information about word forms and related reference objects mentioned in critical utterances. These findings show that understanding of utterances as different communicative actions is reflected in distinct brain activation patterns, and thus suggest different neural substrates for different speech act types. PMID:26505303

Brain basis of communicative actions in language.

PubMed

Egorova, Natalia; Shtyrov, Yury; Pulvermüller, Friedemann

2016-01-15

Although language is a key tool for communication in social interaction, most studies in the neuroscience of language have focused on language structures such as words and sentences. Here, the neural correlates of speech acts, that is, the actions performed by using language, were investigated with functional magnetic resonance imaging (fMRI). Participants were shown videos, in which the same critical utterances were used in different communicative contexts, to Name objects, or to Request them from communication partners. Understanding of critical utterances as Requests was accompanied by activation in bilateral premotor, left inferior frontal and temporo-parietal cortical areas known to support action-related and social interactive knowledge. Naming, however, activated the left angular gyrus implicated in linking information about word forms and related reference objects mentioned in critical utterances. These findings show that understanding of utterances as different communicative actions is reflected in distinct brain activation patterns, and thus suggest different neural substrates for different speech act types. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Using the Self-Select Paradigm to Delineate the Nature of Speech Motor Programming

PubMed Central

Wright, David L.; Robin, Don A.; Rhee, Jooyhun; Vaculin, Amber; Jacks, Adam; Guenther, Frank H.; Fox, Peter T.

2015-01-01

Purpose The authors examined the involvement of 2 speech motor programming processes identified by S. T. Klapp (1995, 2003) during the articulation of utterances differing in syllable and sequence complexity. According to S. T. Klapp, 1 process, INT, resolves the demands of the programmed unit, whereas a second process, SEQ, oversees the serial order demands of longer sequences. Method A modified reaction time paradigm was used to assess INT and SEQ demands. Specifically, syllable complexity was dependent on syllable structure, whereas sequence complexity involved either repeated or unique syllabi within an utterance. Results INT execution was slowed when articulating single syllables in the form CCCV compared to simpler CV syllables. Planning unique syllables within a multisyllabic utterance rather than repetitions of the same syllable slowed INT but not SEQ. Conclusions The INT speech motor programming process, important for mental syllabary access, is sensitive to changes in both syllable structure and the number of unique syllables in an utterance. PMID:19474396

Semiotic diversity in utterance production and the concept of 'language'.

PubMed

Kendon, Adam

2014-09-19

Sign language descriptions that use an analytic model borrowed from spoken language structural linguistics have proved to be not fully appropriate. Pictorial and action-like modes of expression are integral to how signed utterances are constructed and to how they work. However, observation shows that speakers likewise use kinesic and vocal expressions that are not accommodated by spoken language structural linguistic models, including pictorial and action-like modes of expression. These, also, are integral to how speaker utterances in face-to-face interaction are constructed and to how they work. Accordingly, the object of linguistic inquiry should be revised, so that it comprises not only an account of the formal abstract systems that utterances make use of, but also an account of how the semiotically diverse resources that all languaging individuals use are organized in relation to one another. Both language as an abstract system and languaging should be the concern of linguistics. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Auditory Training with Frequent Communication Partners

ERIC Educational Resources Information Center

Tye-Murray, Nancy; Spehar, Brent; Sommers, Mitchell; Barcroft, Joe

2016-01-01

Purpose: Individuals with hearing loss engage in auditory training to improve their speech recognition. They typically practice listening to utterances spoken by unfamiliar talkers but never to utterances spoken by their most frequent communication partner (FCP)--speech they most likely desire to recognize--under the assumption that familiarity…

Second Language Learners and Speech Act Comprehension

ERIC Educational Resources Information Center

Holtgraves, Thomas

2007-01-01

Recognizing the specific speech act ( Searle, 1969) that a speaker performs with an utterance is a fundamental feature of pragmatic competence. Past research has demonstrated that native speakers of English automatically recognize speech acts when they comprehend utterances (Holtgraves & Ashley, 2001). The present research examined whether this…

Child implant users' imitation of happy- and sad-sounding speech

PubMed Central

Wang, David J.; Trehub, Sandra E.; Volkova, Anna; van Lieshout, Pascal

2013-01-01

Cochlear implants have enabled many congenitally or prelingually deaf children to acquire their native language and communicate successfully on the basis of electrical rather than acoustic input. Nevertheless, degraded spectral input provided by the device reduces the ability to perceive emotion in speech. We compared the vocal imitations of 5- to 7-year-old deaf children who were highly successful bilateral implant users with those of a control sample of children who had normal hearing. First, the children imitated several happy and sad sentences produced by a child model. When adults in Experiment 1 rated the similarity of imitated to model utterances, ratings were significantly higher for the hearing children. Both hearing and deaf children produced poorer imitations of happy than sad utterances because of difficulty matching the greater pitch modulation of the happy versions. When adults in Experiment 2 rated electronically filtered versions of the utterances, which obscured the verbal content, ratings of happy and sad utterances were significantly differentiated for deaf as well as hearing children. The ratings of deaf children, however, were significantly less differentiated. Although deaf children's utterances exhibited culturally typical pitch modulation, their pitch modulation was reduced relative to that of hearing children. One practical implication is that therapeutic interventions for deaf children could expand their focus on suprasegmental aspects of speech perception and production, especially intonation patterns. PMID:23801976

Pronunciation difficulty, temporal regularity, and the speech-to-song illusion.

PubMed

Margulis, Elizabeth H; Simchy-Gross, Rhimmon; Black, Justin L

2015-01-01

The speech-to-song illusion (Deutsch et al., 2011) tracks the perceptual transformation from speech to song across repetitions of a brief spoken utterance. Because it involves no change in the stimulus itself, but a dramatic change in its perceived affiliation to speech or to music, it presents a unique opportunity to comparatively investigate the processing of language and music. In this study, native English-speaking participants were presented with brief spoken utterances that were subsequently repeated ten times. The utterances were drawn either from languages that are relatively difficult for a native English speaker to pronounce, or languages that are relatively easy for a native English speaker to pronounce. Moreover, the repetition could occur at regular or irregular temporal intervals. Participants rated the utterances before and after the repetitions on a 5-point Likert-like scale ranging from "sounds exactly like speech" to "sounds exactly like singing." The difference in ratings before and after was taken as a measure of the strength of the speech-to-song illusion in each case. The speech-to-song illusion occurred regardless of whether the repetitions were spaced at regular temporal intervals or not; however, it occurred more readily if the utterance was spoken in a language difficult for a native English speaker to pronounce. Speech circuitry seemed more liable to capture native and easy-to-pronounce languages, and more reluctant to relinquish them to perceived song across repetitions.

A Pragmatic Study of Humor

ERIC Educational Resources Information Center

Ibraheem, Sura Dhiaa; Abbas, Nawal Fadhil

2016-01-01

Linguistically speaking, the concept of humor, which seems to be vast for people, has specific dimensions by which it is generated including: puns, irony, sarcasm, wittiness, and contrastive utterances in relation to the speakers of those utterances. It is about how the extra linguistics elements dominate the situation and the delivery of humor.…

Dialogic Linkage and Resonance in Autism

ERIC Educational Resources Information Center

Hobson, R. Peter; Hobson, Jessica A.; Garcia-Perez, Rosa; Du Bois, John

2012-01-01

We evaluated how children with autism make linguistic adjustments when talking with someone else. We devised two novel measures to assess (a) overall conversational linkage and (b) utterance-by-utterance resonance within dialogue between an adult and matched participants with and without autism (n = 12 per group). Participants with autism were…

The advantages of wearable green reflected photoplethysmography.

PubMed

Maeda, Yuka; Sekine, Masaki; Tamura, Toshiyo

2011-10-01

This report evaluates the efficacy of reflected-type green light photoplethysmography (green light PPG). Transmitted infrared light was used for PPG and the arterial pulse was monitored transcutaneously. The reflected PPG signal contains AC components based on the heartbeat-related signal from the arterial blood flow and DC components, which include reflectance and scattering from tissue. Generally, changes in AC components are monitored, but the DC components play an important role during heat stress. In this study, we compared the signal of green light PPG to infrared PPG and ECG during heat stress. The wavelengths of the green and infrared light were 525 nm and 880 nm, respectively. Experiments were performed on young healthy subjects in cold (10°C), hot (45°C), and normal environments. The pulse rates were compared among three measurement devices and the AC and DC components of the PPG signal were evaluated during heat stress. The pulse rates obtained from green light PPG were strongly correlated with the R-R interval of an electrocardiogram in all environments, but those obtained from infrared light PPG displayed a weaker correlation with cold exposure. The AC components were of similar signal output for both wavelengths during heat stress. Also, the DC components for green light PPG were similar during heat stress, but showed less signal output for infrared light PPG during hot exposure. The main reason for the reduced DC components was speculated to be the increased blood flow at the vascular bed. Therefore, reflected green light PPG can be useful for pulse rate monitoring because it is less influenced by the tissue and vein region.

Effects of prosodically modulated sub-phonetic variation on lexical competition.

PubMed

Salverda, Anne Pier; Dahan, Delphine; Tanenhaus, Michael K; Crosswhite, Katherine; Masharov, Mikhail; McDonough, Joyce

2007-11-01

Eye movements were monitored as participants followed spoken instructions to manipulate one of four objects pictured on a computer screen. Target words occurred in utterance-medial (e.g., Put the cap next to the square) or utterance-final position (e.g., Now click on the cap). Displays consisted of the target picture (e.g., a cap), a monosyllabic competitor picture (e.g., a cat), a polysyllabic competitor picture (e.g., a captain) and a distractor (e.g., a beaker). The relative proportion of fixations to the two types of competitor pictures changed as a function of the position of the target word in the utterance, demonstrating that lexical competition is modulated by prosodically conditioned phonetic variation.

Generic Language and Judgements about Category Membership: Can Generics Highlight Properties as Central?

ERIC Educational Resources Information Center

Hollander, Michelle A.; Gelman, Susan A.; Raman, Lakshmi

2009-01-01

Many languages distinguish generic utterances (e.g., "Tigers are ferocious") from non-generic utterances (e.g., "Those tigers are ferocious"). Two studies examined how generic language specially links properties and categories. We used a novel-word extension task to ask if 4- to 5-year-old children and adults distinguish…

Speech Compensation for Time-Scale-Modified Auditory Feedback

ERIC Educational Resources Information Center

Ogane, Rintaro; Honda, Masaaki

2014-01-01

Purpose: The purpose of this study was to examine speech compensation in response to time-scale-modified auditory feedback during the transition of the semivowel for a target utterance of /ija/. Method: Each utterance session consisted of 10 control trials in the normal feedback condition followed by 20 perturbed trials in the modified auditory…

Reference in Action: Links between Pointing and Language

ERIC Educational Resources Information Center

Cooperrider, Kensy Andrew

2011-01-01

When referring to things in the world, speakers produce utterances that are composites of speech and action. Pointing gestures are a pervasive part of such composite utterances, but many questions remain about exactly how pointing is integrated with speech. In this dissertation I present three strands of research that investigate relations of…

Analysis of False Starts in Spontaneous Speech.

ERIC Educational Resources Information Center

O'Shaughnessy, Douglas

A primary difference between spontaneous speech and read speech concerns the use of false starts, where a speaker interrupts the flow of speech to restart his or her utterance. A study examined the acoustic aspects of such restarts in a widely-used speech database, examining approximately 1000 utterances, about 10% of which contained a restart.…

Utterance in the Classroom: Dialogic Motives for Invention.

ERIC Educational Resources Information Center

Hunt, Russell A.

Collaboration in writing is not confined to conventional multiple authorship and peer editing, but extends across the text to include its readers. Strong support for language development comes from dialogic situations in which student writing is created as a response to some other utterance, and yet classrooms rarely support such situations. The…

Pragmatic Functions in Late Talkers: A 1-Year Follow-Up Study

ERIC Educational Resources Information Center

MacRoy-Higgins, Michelle; Kliment, Sarah

2017-01-01

This study analyzed spontaneous language samples of three-year-olds with a history of expressive language delay (late talkers) and age-matched controls using Dore's Conversational Acts analysis (1978) and Mean Length of Utterance (MLU; Brown, 1973). Differences were observed between groups in utterances classified as organizational device and…

The Utterance as Speech Genre in Mikhail Bakhtin's Philosophy of Language.

ERIC Educational Resources Information Center

McCord, Michael A.

This paper focuses on one of the central concepts of Mikhail Bakhtin's philosophy of language: his theory of the utterance as speech genre. Before exploring speech genres, the paper discusses Bakhtin's ideas concerning language--both language as a general system, and the use of language as particular speech communication. The paper considers…

The Role of Speech Rhythm in Language Discrimination: Further Tests with a Non-Human Primate

ERIC Educational Resources Information Center

Tincoff, Ruth; Hauser, Marc; Tsao, Fritz; Spaepen, Geertrui; Ramus, Franck; Mehler, Jacques

2005-01-01

Human newborns discriminate languages from different rhythmic classes, fail to discriminate languages from the same rhythmic class, and fail to discriminate languages when the utterances are played backwards. Recent evidence showing that cotton-top tamarins discriminate Dutch from Japanese, but not when utterances are played backwards, is…

Passionate Utterance and Moral Education

ERIC Educational Resources Information Center

Munday, Ian

2009-01-01

This paper explores Stanley Cavell's notion of "passionate utterance", which acts as an extension of/departure from (we might read it as both) J. L. Austin's theory of the performative. Cavell argues that Austin having made the revolutionary discovery that truth claims in language are bound up with how words perform, then gets bogged by convention…

Use of Word Length Information in Utterance Planning

ERIC Educational Resources Information Center

Meyer, Antje S.; Belke, Eva; Hacker, Christine; Mortensen, Linda

2007-01-01

Griffin [Griffin, Z. M. (2003). "A reversed length effect in coordinating the preparation and articulation of words in speaking." "Psychonomic Bulletin & Review," 10, 603-609.] found that speakers naming object pairs spent more time before utterance onset looking at the second object when the first object name was short than when it was long. She…

Differentiating Children with and without Language Impairment Based on Grammaticality

ERIC Educational Resources Information Center

Eisenberg, Sarita L.; Guo, Ling-Yu

2013-01-01

Purpose: This study compared the diagnostic accuracy of a general grammaticality measure (i.e., percentage grammatical utterance; PGU) to 2 less comprehensive measures of grammaticality--a measure that excluded utterances without a subject and/or main verb (i.e., percentage sentence point; PSP) and a measure that looked only at verb tense errors…

Dialogic Ruptures: An Ethical Imperative

ERIC Educational Resources Information Center

Arndt, Sonja

2017-01-01

Dialogue is promoted as a key strategy to "solve" the "problem" of diversity in educational settings. Yet, "[w]hen we select words … We usually take them from other utterances, and mainly from utterances that are kindred to ours in genre, that is in theme, composition or style" (p. 87, emphasis in the original). This…

Understanding Old Words with New Meanings.

ERIC Educational Resources Information Center

Clark, Herbert H.; Gerrig, Richard J.

1983-01-01

Assumptions about comprehension of utterances are challenged in two experiments using as an example the verb phrase "to do a Richard Nixon on a tape" (i.e., erase it). It is argued that creating meanings, as with this phrase, works differently from selecting senses for utterances and that many require a mixture of the two. (MSE)

Young Children's Understanding of Markedness in Non-Verbal Communication

ERIC Educational Resources Information Center

Liebal, Kristin; Carpenter, Malinda; Tomasello, Michael

2011-01-01

Speakers often anticipate how recipients will interpret their utterances. If they wish some other, less obvious interpretation, they may "mark" their utterance (e.g. with special intonations or facial expressions). We investigated whether two- and three-year-olds recognize when adults mark a non-verbal communicative act--in this case a pointing…

Learning Words from Labeling and Directive Speech

ERIC Educational Resources Information Center

Callanan, Maureen A.; Akhtar, Nameera; Sussman, Lisa

2014-01-01

Despite the common intuition that labeling may be the best way to teach a new word to a child, systematic testing is needed of the prediction that children learn words better from labeling utterances than from directive utterances. Two experiments compared toddlers' label learning in the context of hearing words used in directive versus labeling…

Causal Inference and Language Comprehension: Event-Related Potential Investigations

ERIC Educational Resources Information Center

Davenport, Tristan S.

2014-01-01

The most important information conveyed by language is often contained not in the utterance itself, but in the interaction between the utterance and the comprehender's knowledge of the world and the current situation. This dissertation uses psycholinguistic methods to explore the effects of a common type of inference--causal inference--on language…

Pragmatic Inferences in Context: Learning to Interpret Contrastive Prosody

ERIC Educational Resources Information Center

Kurumada, Chigusa; Clark, Eve V.

2017-01-01

Can preschoolers make pragmatic inferences based on the intonation of an utterance? Previous work has found that young children appear to ignore intonational meanings and come to understand contrastive intonation contours only after age six. We show that four-year-olds succeed in interpreting an English utterance, such as "It LOOKS like a…

For a new look at 'lexical errors': evidence from semantic approximations with verbs in aphasia.

PubMed

Duvignau, Karine; Tran, Thi Mai; Manchon, Mélanie

2013-08-01

The ability to understand the similarity between two phenomena is fundamental for humans. Designated by the term analogy in psychology, this ability plays a role in the categorization of phenomena in the world and in the organisation of the linguistic system. The use of analogy in language often results in non-standard utterances, particularly in speakers with aphasia. These non-standard utterances are almost always studied in a nominal context and considered as errors. We propose a study of the verbal lexicon and present findings that measure, by an action-video naming task, the importance of verb-based non-standard utterances made by 17 speakers with aphasia ("la dame déshabille l'orange"/the lady undresses the orange, "elle casse la tomate"/she breaks the tomato). The first results we have obtained allow us to consider these type of utterances from a new perspective: we propose to eliminate the label of "error", suggesting that they may be viewed as semantic approximations based upon a relationship of inter-domain synonymy and are ingrained in the heart of the lexical system.

Provider-patient adherence dialogue in HIV care: results of a multisite study.

PubMed

Laws, M Barton; Beach, Mary Catherine; Lee, Yoojin; Rogers, William H; Saha, Somnath; Korthuis, P Todd; Sharp, Victoria; Wilson, Ira B

2013-01-01

Few studies have analyzed physician-patient adherence dialogue about ARV treatment in detail. We comprehensively describe physician-patient visits in HIV care, focusing on ARV-related dialogue, using a system that assigns each utterance both a topic code and a speech act code. Observational study using audio recordings of routine outpatient visits by people with HIV at specialty clinics. Providers were 34 physicians and 11 non-M.D. practitioners. Of 415 patients, 66% were male, 59% African-American. 78% reported currently taking ARVs. About 10% of utterances concerned ARV treatment. Among those using ARVs, 15% had any adherence problem solving dialogue. ARV problem solving talk included significantly more directives and control parameter utterances by providers than other topics. Providers were verbally dominant, asked five times as many questions as patients, and made 21 times as many directive utterances. Providers asked few open questions, and rarely checked patients' understanding. Physicians respond to the challenges of caring for patients with HIV by adopting a somewhat physician-centered approach which is particularly evident in discussions about ARV adherence.

Anticipatory other-completion of augmentative and alternative communication talk: a conversation analysis study.

PubMed

Bloch, Steven

2011-01-01

The study described here investigates the practice of anticipatory completion of augmentative and alternative communication (AAC) utterances in progress. The aims were to identify and analyse features of this practice as they occur in natural conversation between a person using an AAC system and a family member. The methods and principles of Conversation Analysis (CA) were used to video record conversations between people with progressive neurological diseases and a progressive speech disorder (dysarthria) and their family members. Key features of interaction were identified and extracts transcribed. Four extracts of talk between a man with motor neurone disease/amyotrophic lateral sclerosis and his mother are presented here. Anticipatory completion of AAC utterances is intimately related to the sequential context in which such utterances occur. Difficulties can arise from topic shifts, understanding the intended action of an AAC word in progress and in recognising the possible end point an utterance. The analysis highlights the importance of understanding how AAC talk works in everyday interaction. The role of co-participants is particularly important here. These results may have implications for both AAC software design and clinical intervention.

Spatial and temporal modifications of multitalker speech can improve speech perception in older adults.

PubMed

Gygi, Brian; Shafiro, Valeriy

2014-04-01

Speech perception in multitalker environments often requires listeners to divide attention among several concurrent talkers before focusing on one talker with pertinent information. Such attentionally demanding tasks are particularly difficult for older adults due both to age-related hearing loss (presbacusis) and general declines in attentional processing and associated cognitive abilities. This study investigated two signal-processing techniques that have been suggested as a means of improving speech perception accuracy of older adults: time stretching and spatial separation of target talkers. Stimuli in each experiment comprised 2-4 fixed-form utterances in which listeners were asked to consecutively 1) detect concurrently spoken keywords in the beginning of the utterance (divided attention); and, 2) identify additional keywords from only one talker at the end of the utterance (selective attention). In Experiment 1, the overall tempo of each utterance was unaltered or slowed down by 25%; in Experiment 2 the concurrent utterances were spatially coincident or separated across a 180-degree hemifield. Both manipulations improved performance for elderly adults with age-appropriate hearing on both tasks. Increasing the divided attention load by attending to more concurrent keywords had a marked negative effect on performance of the selective attention task only when the target talker was identified by a keyword, but not by spatial location. These findings suggest that the temporal and spatial modifications of multitalker speech improved perception of multitalker speech primarily by reducing competition among cognitive resources required to perform attentionally demanding tasks. Published by Elsevier B.V.

Phonological Words and Stuttering on Function Words

PubMed Central

Au-Yeung, James; Howell, Peter; Pilgrim, Lesley

2007-01-01

Stuttering on function words was examined in 51 people who stutter. The people who stutter were subdivided into young (2 to 6 years), middle (6 to 9 years), and older (9 to 12 years) child groups; teenagers (13 to 18 years); and adults (20 to 40 years). As reported by previous researchers, children up to about age 9 stuttered more on function words (pronouns, articles, prepositions, conjunctions, auxiliary verbs), whereas older people tended to stutter more on content words (nouns, main verbs, adverbs, adjectives). Function words in early positions in utterances, again as reported elsewhere, were more likely to be stuttered than function words at later positions in an utterance. This was most apparent for the younger groups of speakers. For the remaining analyses, utterances were segmented into phonological words on the basis of Selkirk’s work (1984). Stuttering rate was higher when function words occurred in early phonological word positions than other phonological word positions whether the phonological word appeared in initial position in an utterance or not. Stuttering rate was highly dependent on whether the function word occurred before or after the single content word allowed in Selkirk’s (1984) phonological words. This applied, once again, whether the phonological word was utterance-initial or not. It is argued that stuttering of function words before their content word in phonological words in young speakers is used as a delaying tactic when the forthcoming content word is not prepared for articulation. PMID:9771625

Prosodic skills in children with Down syndrome and in typically developing children.

PubMed

Zampini, Laura; Fasolo, Mirco; Spinelli, Maria; Zanchi, Paola; Suttora, Chiara; Salerni, Nicoletta

2016-01-01

Many studies have analysed language development in children with Down syndrome to understand better the nature of their linguistic delays and the reason why these delays, particularly those in the morphosyntactic area, seem greater than their cognitive impairment. However, the prosodic characteristics of language development in children with Down syndrome have been scarcely investigated. To analyse the prosodic skills of children with Down syndrome in the production of multi-word utterances. Data on the prosodic skills of these children were compared with data on typically developing children matched on developmental age and vocabulary size. Between-group differences and the relationships between prosodic and syntactic skills were investigated. The participants were nine children with Down syndrome (who ranged in chronological age from 45 to 63 months and had a mean developmental age of 30 months) and 12 30-month-old typically developing children. The children in both groups had a vocabulary size of approximately 450 words. The children's spontaneous productions were recorded during observations of mother-child play sessions. Data analyses showed that despite their morphosyntactic difficulties, children with Down syndrome were able to master some aspects of prosody in multi-word utterances. They were able to produce single intonation multi-word utterances on the same level as typically developing children. In addition, the intonation contour of their utterances was not negatively influenced by syntactic complexity, contrary to what occurred in typically developing children, although it has to be considered that the utterances produced by children with Down syndrome were less complex than those produced by children in the control group. However, children with Down syndrome appeared to be less able than typically developing children to use intonation to express the pragmatic interrogative function. The findings are discussed considering the effects of social experience on the utterance prosodic realization. © 2015 Royal College of Speech and Language Therapists.

Reliability associated with the Roter Interaction Analysis System (RIAS) adapted for the telemedicine context.

PubMed

Nelson, Eve-Lynn; Miller, Edward Alan; Larson, Kiley A

2010-01-01

This study's purpose was to adapt the Roter Interaction Analysis System (RIAS) for telemedicine clinics and to investigate the adapted measure's reliability. The study also sought to better understand the volume of technology-related utterance in established telemedicine clinics and the feasibility of using the measure within the telemedicine setting. This initial evaluation is a first step before broadly using the adapted measure across technologies and raters. An expert panel adapted the RIAS for the telemedicine context. This involved accounting for all consultation participants (patient, provider, presenter, family) and adding technology-specific subcategories. Ten new and 36 follow-up telemedicine encounters were videotaped and double coded using the adapted RIAS. These consisted primarily of follow-up visits (78.0%) involving patients, providers, presenters, and other parties. Reliability was calculated for those categories with 15 or more utterances. Traditional RIAS categories related to socioemotional and task-focused clusters had fair to excellent levels of reliability in the telemedicine setting. Although there were too few utterances to calculate the reliability of the specific technology-related subcategories, the summary technology-related category proved reliable for patients, providers, and presenters. Overall patterns seen in traditional patient-provider interactions were observed, with the number of provider utterances far exceeding patient, presenter, and family utterances, and few technology-specific utterances. The traditional RIAS is reliable when applied across multiple participants in the telemedicine context. Reliability of technology-related subcategories could not be evaluated; however, the aggregate technology-related cluster was found to be reliable and may be especially relevant in understanding communication patterns with patients new to the telemedicine setting. Use of the RIAS instrument is encouraged to facilitate comparison between traditional, face-to-face clinics and telemedicine; among diverse consultation mediums and technologies; and across different specialties. Future research is necessary to further investigate the reliability and validity of adding technology-related subcategories to the RIAS. The limited number of technology-related utterances, however, implies a certain degree of comfort with two-way interactive video consultation among study participants. Telemedicine continues to increase access to healthcare. The technology-related categories of the adapted RIAS were reliable when aggregated, thereby providing a tool to better understand how telemedicine affects provider-patient communication and outcomes.

Non-vitamin K antagonist oral anticoagulants have better efficacy and equivalent safety compared to warfarin in elderly patients with atrial fibrillation: A systematic review and meta-analysis.

PubMed

Kim, In-Soo; Kim, Hyun-Jung; Kim, Tae-Hoon; Uhm, Jae-Sun; Joung, Boyoung; Lee, Moon-Hyoung; Pak, Hui-Nam

2018-08-01

To evaluate the efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) in elderly patients (aged ≥75 years) with atrial fibrillation (AF), depending on dose and/or renal function. After systematically searching the databases (Medline, EMBASE, CENTRAL, SCOPUS, and Web of Science), 5 phase III randomized controlled trials and reported data according to subgroups of elderly/non-elderly AF patients, comparing any NOACs and warfarin were included. The primary efficacy and safety outcomes were stroke/systemic thromboembolism and major bleeding. (1) NOACs showed better efficacy than warfarin in elderly patients [RR 0.83 (0.69-1.00), p=0.04, I 2 =55%], but equivalent efficacy in non-elderly patients. (2) NOACs reduced major bleeding compared to warfarin in non-elderly (p<0.001) and had comparable safety to warfarin in elderly patients. (3) Even in elderly patients with moderately impaired renal function, NOACs had a safety profile comparable to that of warfarin for major bleeding if dose reduction was reached appropriately [pooled RR 0.82 (0.35-1.88), p=0.63, I 2 =63%]. (4) All-cause mortality was lower with NOACs in non-elderly patients [RR 0.89 (0.83-0.95), p=0.001, I 2 =0%], and with standard-dose NOAC group of elderly patients [RR 0.93 (0.86-1.00), p=0.04, I 2 =0%] compared to warfarin. For elderly patients (aged ≥75 years), NOACs showed better efficacy and equivalent safety compared to warfarin even in those with moderately impaired renal function. All-cause mortality was lower with standard-dose NOACs compared to warfarin in the elderly patient group. The protocol of this meta-analysis was registered on PROSPERO under CRD42016047922 (https://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016047922). Copyright © 2018 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial.

PubMed

Murphy, Sabina A; Cannon, Christopher P; Blazing, Michael A; Giugliano, Robert P; White, Jennifer A; Lokhnygina, Yuliya; Reist, Craig; Im, KyungAh; Bohula, Erin A; Isaza, Daniel; Lopez-Sendon, Jose; Dellborg, Mikael; Kher, Uma; Tershakovec, Andrew M; Braunwald, Eugene

2016-02-02

Intensive low-density lipoprotein cholesterol therapy with ezetimibe/simvastatin in IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial) significantly reduced the first primary endpoint (PEP) in patients post-acute coronary syndrome (ACS) compared to placebo/simvastatin. This analysis tested the hypothesis that total events, including those beyond the first event, would also be reduced with ezetimibe/simvastatin therapy. All PEP events (cardiovascular [CV] death, myocardial infarction [MI], stroke, unstable angina [UA] leading to hospitalization, coronary revascularization ≥30 days post-randomization) during a median 6-year follow-up were analyzed in patients randomized to receive ezetimibe/simvastatin or placebo/simvastatin in IMPROVE-IT. Negative binomial regression was used for the primary analysis. Among 18,144 patients, there were 9,545 total PEP events (56% were first events and 44% subsequent events). Total PEP events were significantly reduced by 9% with ezetimibe/simvastatin vs placebo/simvastatin (incidence-rate ratio [RR]: 0.91; 95% confidence interval [CI]: 0.85 to 0.97; p = 0.007), as were the 3 pre-specified secondary composite endpoints and the exploratory composite endpoint of CV death, MI, or stroke (RR: 0.88; 95% CI: 0.81 to 0.96; p = 0.002). The reduction in total events was driven by decreases in total nonfatal MI (RR: 0.87; 95% CI: 0.79 to 0.96; p = 0.004) and total NF stroke (RR: 0.77; 95% CI: 0.65 to 0.93; p = 0.005). Lipid-lowering therapy with ezetimibe plus simvastatin improved clinical outcomes. Reductions in total PEP events, driven by reductions in MI and stroke, more than doubled the number of events prevented compared with examining only the first event. These data support continuation of intensive combination lipid-lowering therapy after an initial CV event. (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial [IMPROVE-IT]; NCT00202878). Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

The Influence of Discourse Context on Children's Provision of Auxiliary BE

ERIC Educational Resources Information Center

Theakston, Anna L.; Lieven, Elena V. M.

2008-01-01

LChildren pass through a stage in development when they produce utterances that contain auxiliary BE ("he's playing") and utterances where auxiliary BE is omitted ("he playing"). One explanation that has been put forward to explain this phenomenon is the presence of questions in the input that model S-V word order (Theakston, Lieven & Tomasello,…

The Quantitative Study of Communicative Success: Politeness and Accidents in Aviation Discourse.

ERIC Educational Resources Information Center

Linde, Charlotte

1988-01-01

Uses transcripts of eight aviation accidents and 14 flight simulator sessions to study mitigation. A four-degree scale is developed to quantify the use of mitigation: (1) high mitigation; (2) low mitigation; (3) direct utterance; and (4) aggravation. Mitigation is sensitive to social rank and sometimes less effective than direct utterances in…

The Effect of Nonverbal Cues on the Interpretation of Utterances by People with Visual Impairments

ERIC Educational Resources Information Center

Sak-Wernicka, Jolanta

2014-01-01

Introduction: The purpose of this article is to explore the effect of nonverbal information (gestures and facial expressions) provided in real time on the interpretation of utterances by people with total blindness. Methods: The article reports on an exploratory study performed on two groups of participants with visual impairments who were tested…

Effects of Prosodically Modulated Sub-Phonetic Variation on Lexical Competition

ERIC Educational Resources Information Center

Salverda, Anne Pier; Dahan, Delphine; Tanenhaus, Michael K.; Crosswhite, Katherine; Masharov, Mikhail; McDonough, Joyce

2007-01-01

Eye movements were monitored as participants followed spoken instructions to manipulate one of four objects pictured on a computer screen. Target words occurred in utterance-medial (e.g., "Put the cap next to the square") or utterance-final position (e.g., "Now click on the cap"). Displays consisted of the target picture (e.g., a cap), a…

Kindergartners' Spontaneous Focusing on Numerosity in Relation to Their Number-Related Utterances during Numerical Picture Book Reading

ERIC Educational Resources Information Center

Rathé, Sanne; Torbeyns, Joke; Hannula-Sormunen, Minna M.; Verschaffel, Lieven

2016-01-01

This study investigated the relationship between kindergartners' Spontaneous Focusing on Numerosity (SFON) and their number-related utterances during numerical picture book reading. Forty-eight 4- to 5-year-olds were individually interviewed via a SFON Imitation Task and a numerical picture book reading activity. We expected differences in the…

Halting in Single Word Production: A Test of the Perceptual Loop Theory of Speech Monitoring

ERIC Educational Resources Information Center

Slevc, L. Robert; Ferreira, Victor S.

2006-01-01

The "perceptual loop theory" of speech monitoring (Levelt, 1983) claims that inner and overt speech are monitored by the comprehension system, which detects errors by comparing the comprehension of formulated utterances to originally intended utterances. To test the perceptual loop monitor, speakers named pictures and sometimes attempted to halt…

Variability in Conversation Management: Fragmentation of Discourse and Back-Channel Expressions in Japanese and English.

ERIC Educational Resources Information Center

Maynard, Senko K.

The casual conversation of six pairs of Japanese and six pairs of American colleges students was analyzed for evidence of two related aspects of conversation management: the linguistic characteristics of utterance units and back-channel strategies. Utterance units are defined as those occurring between identifiable pauses or breaks in tempo.…

The "Research Paper" Prompt: A Dialogic Opportunity for Transfer

ERIC Educational Resources Information Center

Dirk, Kerry

2012-01-01

The treatment of a research paper as an isolated utterance within a composition classroom is problematic in that such papers may fail to encourage transfer of writing knowledge. In this essay, I argue that a research paper's failure to work as a utterance situated within a conversation--as critiqued through a framework constructed by Mikhail…

Assessing the Impact of Conversational Overlap in Content on Child Language Growth

ERIC Educational Resources Information Center

Che, Elizabeth S.; Brooks, Patricia J.; Alarcon, Maria F.; Yannaco, Francis D.; Donnelly, Seamus

2018-01-01

When engaged in conversation, both parents and children tend to re-use words that their partner has just said. This study explored whether proportions of maternal and/or child utterances that overlapped in content with what their partner had just said contributed to growth in mean length of utterance (MLU), developmental sentence score, and…

Revising Segmentation Hypotheses in First and Second Language Listening

ERIC Educational Resources Information Center

Field, John

2008-01-01

Any on-line processing that takes place while an utterance is unfolding is extremely tentative, with early-formed hypotheses having to be revised as the utterance proceeds. The hypotheses in question relate not only to the words that are present but also to where their boundaries fall. This study examines how first and second language listeners…

From Bakhtin to See the Co-Construction of EFL Adult Learners' Utterances

ERIC Educational Resources Information Center

Tseng, Chingyi; Huh, Keun

2016-01-01

The purposes of this study were to explore the effect of dialogic activities on EFL students' utterances development by engaging with others, as well as the students' perceptions in the dialogic learning environment. The theoretical framework guiding this inquiry consists of the on-site lecture from the instructor and voice board feedback from the…

Phonological Transcribing of English Utterances in Teaching Listening Comprehension for Korean Students

ERIC Educational Resources Information Center

Cheung, Yun Kul

2009-01-01

The purpose of this paper was to discuss the importance of listening and to examine whether or not transcribing utterances in English using the Korean alphabet improved the accuracy in English sentences produced by a group of Korean college students. A total population of 120 students was divided into two groups, control and experiment. The…

The Relation between Event Apprehension and Utterance Formulation in Children: Evidence from Linguistic Omissions

ERIC Educational Resources Information Center

Bunger, Ann; Trueswell, John C.; Papafragou, Anna

2012-01-01

The relation between event apprehension and utterance formulation was examined in children and adults. English-speaking adults and 4-year-olds viewed motion events while their eye movements were monitored. Half of the participants in each age group described each event (Linguistic task), whereas the other half studied the events for an upcoming…

Calculating Mean Length of Utterance for Eastern Canadian Inuktitut

ERIC Educational Resources Information Center

Allen, Shanley E. M.; Dench, Catherine

2015-01-01

Although virtually all Inuit children in eastern Arctic Canada learn Inuktitut as their native language, there is a critical lack of tools to assess their level of language ability. This article investigates how mean length of utterance (MLU), a widely-used assessment measure in English and other languages, can be best applied in Inuktitut. The…

Infant Word Segmentation Revisited: Edge Alignment Facilitates Target Extraction

ERIC Educational Resources Information Center

Seidl, Amanda; Johnson, Elizabeth K.

2006-01-01

In a landmark study, Jusczyk and Aslin (1995 ) demonstrated that English-learning infants are able to segment words from continuous speech at 7.5 months of age. In the current study, we explored the possibility that infants segment words from the edges of utterances more readily than the middle of utterances. The same procedure was used as in…

Revisiting Speech Rate and Utterance Length Manipulations in Stuttering Speakers

ERIC Educational Resources Information Center

Blomgren, Michael; Goberman, Alexander M.

2008-01-01

The goal of this study was to evaluate stuttering frequency across a multidimensional (2 x 2) hierarchy of speech performance tasks. Specifically, this study examined the interaction between changes in length of utterance and levels of speech rate stability. Forty-four adult male speakers participated in the study (22 stuttering speakers and 22…

Utterances in infant-directed speech are shorter, not slower.

PubMed

Martin, Andrew; Igarashi, Yosuke; Jincho, Nobuyuki; Mazuka, Reiko

2016-11-01

It has become a truism in the literature on infant-directed speech (IDS) that IDS is pronounced more slowly than adult-directed speech (ADS). Using recordings of 22 Japanese mothers speaking to their infant and to an adult, we show that although IDS has an overall lower mean speech rate than ADS, this is not the result of an across-the-board slowing in which every vowel is expanded equally. Instead, the speech rate difference is entirely due to the effects of phrase-final lengthening, which disproportionally affects IDS because of its shorter utterances. These results demonstrate that taking utterance-internal prosodic characteristics into account is crucial to studies of speech rate. Copyright © 2016 Elsevier B.V. All rights reserved.

Effects of prosodically-modulated sub-phonetic variation on lexical competition

PubMed Central

Salverda, Anne Pier; Dahan, Delphine; Tanenhaus, Michael K.; Crosswhite, Katherine; Masharov, Mikhail; McDonough, Joyce

2007-01-01

Eye movements were monitored as participants followed spoken instructions to manipulate one of four objects pictured on a computer screen. Target words occurred in utterance-medial (e.g., Put the cap next to the square) or utterance-final position (e.g., Now click on the cap). Displays consisted of the target picture (e.g., a cap), a monosyllabic competitor picture (e.g., a cat), a polysyllabic competitor picture (e.g., a captain) and a distractor (e.g., a beaker). The relative proportion of fixations to the two types of competitor pictures changed as a function of the position of the target word in the utterance, demonstrating that lexical competition is modulated by prosodically-conditioned phonetic variation. PMID:17141751

Contingency interaction analysis in psychotherapy.

PubMed

Canfield, M L; Walker, W R; Brown, L G

1991-02-01

This article introduces (a) a computerized coding procedure that rates words and utterances in terms of emotion, cognition, and contract and (b) a contingency method of analyzing verbal interactions. Using transcripts of sessions conducted by 3 master therapists with 1 client, the rating procedure and contingency correlation analyses supported the study's hypotheses. Therapists' utterances were characterized by significantly different amounts of emotion, cognition, and contracts, indicating that communication styles varied in the relative emphasis placed on these attributes. Differences suggest that the therapists responded differently to emotional, cognitive, and contract utterances and that the client's responses were different across the 3 therapist interviews. Split halves of the interviews within therapists and within client sessions were not different, providing further evidence of reliability of the coding and contingency procedures.

Detecting Abnormal Word Utterances in Children With Autism Spectrum Disorders: Machine-Learning-Based Voice Analysis Versus Speech Therapists.

PubMed

Nakai, Yasushi; Takiguchi, Tetsuya; Matsui, Gakuyo; Yamaoka, Noriko; Takada, Satoshi

2017-10-01

Abnormal prosody is often evident in the voice intonations of individuals with autism spectrum disorders. We compared a machine-learning-based voice analysis with human hearing judgments made by 10 speech therapists for classifying children with autism spectrum disorders ( n = 30) and typical development ( n = 51). Using stimuli limited to single-word utterances, machine-learning-based voice analysis was superior to speech therapist judgments. There was a significantly higher true-positive than false-negative rate for machine-learning-based voice analysis but not for speech therapists. Results are discussed in terms of some artificiality of clinician judgments based on single-word utterances, and the objectivity machine-learning-based voice analysis adds to judging abnormal prosody.

Laryngeal dynamics of pedagogical taan gestures in Indian classical singing.

PubMed

Radhakrishnan, Nandhakumar; Scherer, Ronald C; Bandyopadhyay, Santanu

2011-05-01

Vocal modulations characterize many styles of singing. Vibrato, trill, and trillo are some of the ornaments that Western classical singers use. Likewise, taan is one of the basic frequency modulations demonstrated by Hindustani Indian classical singers. The objective of this descriptive study was to discover the F₀ contour of taan; establish selected acoustic, aerodynamic, and glottographic characteristics of the taan gesture; and explore the pedagogical taan utterances demonstrated by a well-known singer and teacher. Exploratory. Fundamental frequency, alternating current (AC) glottal flow, and electroglottographic width measures were obtained for taan productions by the classical Indian singer and teacher who demonstrated taan rate variations based on his pedagogical approach. The structure of the taan gesture was found to be an F₀ lowering and rising (the "taan dip") followed by a relatively flat portion (the "taan superior surface"). Rate of the F₀ structure of the taan gestures ranged from approximately 1.65 to 3.41Hz, and the F₀ extent ranged from 1.87 to 2.21semitone (ST). As the rate of the taan gesture increased, the superior surface shortened, whereas the taan dip stayed relatively constant (ranging from 170 to 230 ms). AC flow was greater for the lowest frequencies of the dip and faster rates. The pedagogical taan gesture has a specific structure of an F₀ dip followed by a relatively flat F₀ portion that shortens as taan rate increases. The F₀ dip and extent are relatively robust across rate. The taan productions are voluntarily controlled, in contrast to vibrato productions. Copyright © 2011 The Voice Foundation. Published by Mosby, Inc. All rights reserved.

Changes in hospitalization rates for acute coronary syndrome after a two-phase comprehensive smoking ban.

PubMed

Séguret, Fabienne; Ferreira, Christelle; Cambou, Jean-Pierre; Carrière, Isabelle; Thomas, Daniel

2014-12-01

The impact of a comprehensive stepwise smoking ban (2007 and 2008) was assessed by analysing the hospitalization rate for acute coronary syndrome (ACS) in France, between 2003 and 2009. Between 2003 and 2009, 867,164 hospitalizations for ACS were observed among about 23 million administrative reports. The age-and gender-standardized hospitalization rates were calculated and their variation before and after the smoking ban implementation was investigated by Poisson regression that included the ACS seasonal variations and the historical trend. The hospitalization rate decreased by 12.8% (from 269 to 235/100,000) with a significant historical trend reduction (p < 0.10(-3)) in all groups, but in young women. After adjusting for linear trend, reductions linked to the ban remained not significant in all groups: relative risk (RR) from 0.96 (95% CI 0.91-1.01) in men older than 55 years to 0.99 (95% CI 0.93-1.04) in men aged 55 years or less after the first phase, and from 0.96 (95% CI 0.89-1.04) in men older than 55 years to 1.03 (95% CI 0.94-1.12) in women older than 65 years after the second phase of the ban. This study did not demonstrate a significant effect of a two-phases smoking ban on ACS hospitalization rate. A steadily decrease of this rate over the 7-year period, the past preventive measures in France leading to low levels of passive smoking, and the significant increase in active smoking during the studied period may explain this result. Our study highlights the difficulty of proving an effect of smoking bans in a country with an already low ACS incidence. © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Impact of the Adalimumab Patient Support Program on Clinical Outcomes in Ankylosing Spondylitis: Results from the COMPANION Study.

PubMed

Bessette, Louis; Lebovic, Gerald; Millson, Brad; Charland, Katia; Donepudi, Krishna; Gaetano, Tania; Remple, Valencia; Latour, Martin G; Gazel, Sandra; Laliberté, Marie-Claude; Thorne, Carter

2018-06-01

Adalimumab (ADA) is a tumor necrosis factor (TNF)-alpha inhibitor indicated for the treatment of inflammatory autoimmune diseases, including ankylosing spondylitis (AS). Patients receiving ADA in Canada are eligible to enroll in the AbbVie Care™ patient support program (AC-PSP), which provides personalized services, including care coach calls (CCCs). We estimated the likelihood of controlled disease in a cohort of AS patients treated with ADA enrolled in the AC-PSP and who received CCCs versus those who did not. A longitudinal analysis using de-identified aggregate-level data collected through the AC-PSP was performed. A probabilistic matching algorithm was used to link patient-level records from the AC-PSP database to records from the QuintilesIMS longitudinal prescription transactions database. Patients were indexed on the date of their first prescription of ADA between January 2010 and October 2015. The AC-PSP database included patient assessments of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), a measure of disease activity. Eligible patients had a baseline BASDAI assessment performed between 90 days before and 30 days after the index date, and a follow-up BASDAI assessment 6-18 months later. Poisson regression was used to estimate the adjusted relative risk (RR) of controlled disease (BASDAI < 4) at the time of follow-up, comparing patients who received CCCs with those who did not. In total 249 AS patients met eligibility criteria, and 123 (49%) received CCCs. Of the 249 patients, 184 (74%) had controlled disease (BASDAI < 4) at follow-up assessment, 98 (80%) in the CCC group and 86 (68%) in the no CCC group. Multivariable regression analysis demonstrated a 23% increased likelihood of controlled disease in patients who received CCCs relative to those who did not (RR = 1.23; 95% confidence interval, 1.06-1.42; p = 0.0055). AS patients receiving tailored services through the AC-PSP in the form of CCCs have an increased likelihood of controlled disease within 6-18 months. AbbVie.

Changing word usage predicts changing word durations in New Zealand English.

PubMed

Sóskuthy, Márton; Hay, Jennifer

2017-09-01

This paper investigates the emergence of lexicalized effects of word usage on word duration by looking at parallel changes in usage and duration over 130years in New Zealand English. Previous research has found that frequent words are shorter, informative words are longer, and words in utterance-final position are also longer. It has also been argued that some of these patterns are not simply online adjustments, but are incorporated into lexical representations. While these studies tend to focus on the synchronic aspects of such patterns, our corpus shows that word-usage patterns and word durations are not static over time. Many words change in duration and also change with respect to frequency, informativity and likelihood of occurring utterance-finally. Analysis of changing word durations over this time period shows substantial patterns of co-adaptation between word usage and word durations. Words that are increasing in frequency are becoming shorter. Words that are increasing/decreasing in informativity show a change in the same direction in duration (e.g. increasing informativity is associated with increasing duration). And words that are increasingly appearing utterance-finally are lengthening. These effects exist independently of the local effects of the predictors. For example, words that are increasing utterance-finally lengthen in all positions, including utterance-medially. We show that these results are compatible with a number of different views about lexical representations, but they cannot be explained without reference to a production-perception loop that allows speakers to update their representations dynamically on the basis of their experience. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

New simple evaluation method of the monosyllable /sa/ using a psychoacoustic system in maxillectomy patients.

PubMed

Chowdhury, Nafees Uddin; Otomaru, Takafumi; Murase, Mai; Inohara, Ken; Hattori, Mariko; Sumita, Yuka I; Taniguchi, Hisashi

2011-01-01

An objective assessment of speech would benefit the prosthetic rehabilitation of maxillectomy patients. This study aimed to establish a simple, objective evaluation of monosyllable /sa/ utterances in maxillectomy patients by using a psychoacoustic system typically used in industry. This study comprised two experiments. Experiment 1 involved analysis of the psychoacoustic parameters (loudness, sharpness and roughness) in monosyllable /sa/ utterances by 18 healthy subjects (9 males, 9 females). The utterances were recorded in a sound-treated room. The coefficient of variation (CV) for each parameter was compared to identify the most suitable parameter for objective evaluation of speech. Experiment 2 involved analysis of /sa/ utterances by 18 maxillectomy patients (9 males, 9 females) with and without prosthesis, and comparisons of the psychoacoustic data between the healthy subjects and maxillectomy patients without prosthesis, between the maxillectomy patients with and without prosthesis, and between the healthy subjects and maxillectomy patients with prosthesis. The CV for sharpness was the lowest among the three psychoacoustic parameters in both the healthy males and females. There were significant differences in the sharpness of /sa/ between the healthy subjects and the maxillectomy patients without prosthesis (but not with prosthesis), and between the maxillectomy patients with and without prosthesis. We found that the psychoacoustic parameters typically adopted in industrial research could also be applied to evaluate the psychoacoustics of the monosyllable /sa/ utterance, and distinguished the monosyllable /sa/ in maxillectomy patients with an obturator from that without an obturator using the system. Copyright © 2010 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

Authors' response: forward models and their implications for production, comprehension, and dialogue.

PubMed

Pickering, Martin J; Garrod, Simon

2013-08-01

Our target article proposed that language production and comprehension are interwoven, with speakers making predictions of their own utterances and comprehenders making predictions of other people's utterances at different linguistic levels. Here, we respond to comments about such issues as cognitive architecture and its neural basis, learning and development, monitoring, the nature of forward models, communicative intentions, and dialogue.

The Speech Functions Used by Ibu Muslimah and Pak Harfan in "Laskar Pelangi" Drama

ERIC Educational Resources Information Center

Rahmania

2018-01-01

This research investigates kind of speech function used in utterances created by Ibu Muslimah and Pak Harfan in "Laskar Pelangi" drama. Descriptive qualitative method is conduct for this research. The script of drama Laskar Pelangi was taken as source of data. All utterances produced by bu Muslimah and Pak Harfan as the data in the…

The Developmental Trajectory of Nonadjacent Dependency Learning

ERIC Educational Resources Information Center

Gomez, Rebecca; Maye, Jessica

2005-01-01

We investigated the developmental trajectory of nonadjacent dependency learning in an artificial language. Infants were exposed to 1 of 2 artificial languages with utterances of the form [aXc or bXd] (Grammar 1) or [aXd or bXc] (Grammar 2). In both languages, the grammaticality of an utterance depended on the relation between the 1st and 3rd…

Brief Report: Brain Activation to Social Words in a Sedated Child with Autism

ERIC Educational Resources Information Center

Carmody, Dennis P.; Moreno, Rosanne; Mars, Audrey E.; Seshadri, Kapila; Lambert, George H.; Lewis, Michael

2007-01-01

A functional magnetic resonance imaging (fMRI) study was performed on a 4-year-old girl with autism. While sedated, she listened to three utterances (numbers, hello, her own first name) played through headphones. Based on analyses of the fMRI data, the amount of total brain activation varied with the content of the utterance. The greatest volume…

Relevant Responding in Pragmatic Language Impairment: The Role of Language Variation in the Information-Soliciting Utterance

ERIC Educational Resources Information Center

Vigil, Vannesa T.; Eyer, Julia A.; Hardee, W Paul

2005-01-01

Responding relevantly to an information-soliciting utterance (ISU) is required of a school-age child many times daily. For the child with pragmatic language difficulties, this may be especially problematic, yet clinicians have had few data to design intervention for improving these skills. This small-scale study looks at the ability of a child…

Are Young Children's Utterances Affected by Characteristics of Their Learning Environments? A Multiple Case Study

ERIC Educational Resources Information Center

Richardson, Tanya; Murray, Jane

2017-01-01

Within English early childhood education, there is emphasis on improving speech and language development as well as a drive for outdoor learning. This paper synthesises both aspects to consider whether or not links exist between the environment and the quality of young children's utterances as part of their speech and language development and if…

Sampling Utterances and Grammatical Analysis Revised (SUGAR): New Normative Values for Language Sample Analysis Measures

ERIC Educational Resources Information Center

Pavelko, Stacey L.; Owens, Robert E., Jr.

2017-01-01

Purpose: The purpose of this study was to document whether mean length of utterance (MLU[subscript S]), total number of words (TNW), clauses per sentence (CPS), and/or words per sentence (WPS) demonstrated age-related changes in children with typical language and to document the average time to collect, transcribe, and analyze conversational…

Acoustics of contrastive prosody in children

NASA Astrophysics Data System (ADS)

Patel, Rupal; Piel, Jordan; Grigos, Maria

2005-04-01

Empirical data on the acoustics of prosodic control in children is limited, particularly for linguistically contrastive tasks. Twelve children aged 4, 7, and 11 years were asked to produce two utterances ``Show Bob a bot'' (voiced consonants) and ``Show Pop a pot'' (voiceless consonants) 10 times each with emphasis placed on the second word (Bob/Pop) and 10 times with emphasis placed on the last word (bot/pot). A total of 40 utterances were analyzed per child. The following acoustic measures were obtained for each word within each utterance: average fundamental frequency (f0), peak f0, average intensity, peak intensity, and duration. Preliminary results suggest that 4 year olds are unable to modulate prosodic cues to signal the linguistic contrast. The 7 year olds, however, not only signaled the appropriate stress location, but did so with the most contrastive differences in f0, intensity, and duration, of all age groups. Prosodic differences between stressed and unstressed words were more pronounced for the utterance with voiced consonants. These findings suggest that the acoustics of linguistic prosody begin to differentiate between age 4 and 7 and may be highly influenced by changes in physiological control and flexibility that may also affect segmental features.

Sound Processing Features for Speaker-Dependent and Phrase-Independent Emotion Recognition in Berlin Database

NASA Astrophysics Data System (ADS)

Anagnostopoulos, Christos Nikolaos; Vovoli, Eftichia

An emotion recognition framework based on sound processing could improve services in human-computer interaction. Various quantitative speech features obtained from sound processing of acting speech were tested, as to whether they are sufficient or not to discriminate between seven emotions. Multilayered perceptrons were trained to classify gender and emotions on the basis of a 24-input vector, which provide information about the prosody of the speaker over the entire sentence using statistics of sound features. Several experiments were performed and the results were presented analytically. Emotion recognition was successful when speakers and utterances were “known” to the classifier. However, severe misclassifications occurred during the utterance-independent framework. At least, the proposed feature vector achieved promising results for utterance-independent recognition of high- and low-arousal emotions.

The bizzare phenomenon of smokers' paradox in the immediate outcome post acute myocardial infarction: an insight into the Malaysian National Cardiovascular Database-Acute Coronary Syndrome (NCVD-ACS) registry year 2006-2013.

PubMed

Venkatason, Padmaa; Salleh, Norsabihin Mohd; Zubairi, Yong; Hafidz, Imran; Ahmad, Wan Azman Wan; Han, Sim Kui; Zuhdi, Ahmad Syadi Mahmood

2016-01-01

'Smoker's paradox' is a controversial phenomenon of an unexpected favourable outcome of smokers post acute myocardial infarction. There are conflicting evidences from the literature so far. We investigate for the existence of this phenomenon in our post acute myocardial infarction patients. We analysed 12,442 active smokers and 10,666 never-smokers diagnosed with STEMI and NSTEMI from the Malaysian National Cardiovascular Database-Acute Coronary Syndrome (NCVD-ACS) year 2006-2013 from 18 hospitals across Malaysia. Comparisons in the baseline characteristics, clinical presentation, in-hospital treatment and short term clinical outcome were made between the two groups. To compare the clinical outcome, an extensive multivariate adjustment was made to estimate the allcause mortality risk ratios for both groups. The active smokers were younger (smokers 53.7 years vs non-smokers 62.3 years P < 0.001) and had lower cardiovascular risk burden and other co-morbidities. STEMI is more common in smokers and intravenous thrombolysis was the main reperfusion therapy in both groups. Smokers had a higher rate of in-hsopital coronary revascularisation in NSTEMI group (21.6 % smokers vs 16.7 % non-smokers P < 0.001) but similar to non-smokers in the STEMI group. Multivariate adjusted mortality risk ratios showed significantly lower mortality risks of smokers at both in-hospital (RR 0.510 [95 % CI 0.442-0.613]) and 30-day post discharge (RR 0.534 [95 % CI 0.437-0.621]). Smoking seems to be associated with a favourable outcome post myocardial infarction. The phenomenon of 'smoker's paradox' is in fact a reality in our patients population. The definitive explanation for this unexpected protective effect of smoking remains unclear.

Who Does What to Whom: Person and Case in Children's Utterances.

ERIC Educational Resources Information Center

Klein-Andreu, Flora

A study of children's egocentrism in their use of person and case examined whether 7-year-olds would tend to cast themselves as subjects in sentences using the verbs "give, show, say, tell, and lend," and what role they might assign the hearer. In 85 utterances, the children (N=17), with an average age of 7.8 years, showed the expected…

Mean Length of Utterance in Children with Specific Language Impairment and in Younger Control Children Shows Concurrent Validity and Stable and Parallel Growth Trajectories

ERIC Educational Resources Information Center

Rice, Mabel L.; Redmond, Sean M.; Hoffman, Lesa

2006-01-01

Purpose: Although mean length of utterance (MLU) is a useful benchmark in studies of children with specific language impairment (SLI), some empirical and interpretive issues are unresolved. The authors report on 2 studies examining, respectively, the concurrent validity and temporal stability of MLU equivalency between children with SLI and…

Expressions on Education by American Statesmen and Publicists. Bulletin, 1913, No. 28. Whole Number 538

ERIC Educational Resources Information Center

United States Bureau of Education, Department of the Interior, 1913

1913-01-01

Many who are engaged in educational campaigns have felt the need for a collection of at least a few of the more important utterances of some of the most prominent statesmen and publicists in regard to education and its importance. To supply this need, this bulletin was created. This bulletin presents the utterances of the following individuals:…

Exploring pharmacist-customer communication: the established blood pressure measurement episode.

PubMed

Cavaco, Afonso Neves; Romano, João P

2010-10-01

To characterize the communication ritual in the pharmacist-customer dyad during a blood pressure measurement and counselling episode. A Portuguese urban community pharmacy. An exploratory, cross-sectional design was used. Participants were purposively selected and data collected via audio recording, as well as demographics and clinical information via questionnaire. Encounters' verbal content was transcribed verbatim, utterances identified, time stamped, and classified according to a coding scheme of fifteen categories. All data was statistically analyzed using SPSSv17. Four dialogue structures: speaker turn, interactivity, turn density and turn duration measurements. From a total of 51 participants, 72.5% were female with a median age of 66 years. The average systolic blood pressure was 140 mmHg, while the diastolic was 78 mmHg. The blood pressure measurement episode lasted for 5:35 min, with an average of 81 utterances. From all utterances registered, 55.3% were produced by the customer. Visits averaged 38 speaker turns, with an interactivity rate of approximately 7 turns per episode minute. For pharmacists, turn duration averaged 7.0 s and turn density 2.1 utterances. The customers' turns comprised a mean of 8.0 s, with 2.4 utterances. Longer episodes were related to more speaker turns and greater customer turn density and duration, but lower dialogue interactivity. The interactivity rate was also lower when the customers' utterances increased. Pharmacists asked more questions (essentially closed ones), while the customers gave more information. No significant associations were observed between elderly/non-elderly and gender in relation to all communication variables. However, an increased number of speaker turns and closed-questions were associated to a higher systolic pressure. It seems that pharmacists tend to control the content of the dialogue, while customers have more influence on the visit duration and interactivity. Specific hypertensive episodes induce a higher information search. Since the closed questioning format was prevalent, it seems that open information exchange was limited, mainly serving confirmation purposes rather than having a true exploratory nature. Although talk dominance is balanced, further analysis is required to better inform these results, which would confirm the low interactivity and the reduced information-seeking behaviour showed in the counselling episodes.

Vaginal Cleansing Before Cesarean Delivery: A Systematic Review and Meta-analysis.

PubMed

Caissutti, Claudia; Saccone, Gabriele; Zullo, Fabrizio; Quist-Nelson, Johanna; Felder, Laura; Ciardulli, Andrea; Berghella, Vincenzo

2017-09-01

To assess the efficacy of vaginal cleansing before cesarean delivery in reducing postoperative endometritis. MEDLINE, Ovid, EMBASE, Scopus, Clinicaltrials.gov, and Cochrane Library were searched from their inception to January 2017. Selection criteria included all randomized controlled trials comparing vaginal cleansing (ie, intervention group) with a control group (ie, either placebo or no intervention) in women undergoing cesarean delivery. Any method of vaginal cleansing with any type of antiseptic solution was included. The primary outcome was the incidence of endometritis. Meta-analysis was performed using the random-effects model of DerSimonian and Laird to produce summary treatment effects in terms of relative risk (RR) with 95% CI. Sixteen trials (4,837 women) on vaginal cleansing immediately before cesarean delivery were identified as relevant and included in the review. In most of the included studies, 10% povidone-iodine was used as an intervention. The most common way to perform the vaginal cleansing was the use of a sponge stick for approximately 30 seconds. Women who received vaginal cleansing before cesarean delivery had a significantly lower incidence of endometritis (4.5% compared with 8.8%; RR 0.52, 95% CI 0.37-0.72; 15 studies, 4,726 participants) and of postoperative fever (9.4% compared with 14.9%; RR 0.65, 95% CI 0.50-0.86; 11 studies, 4,098 participants) compared with the control group. In the planned subgroup analyses, the reduction in the incidence of endometritis with vaginal cleansing was limited to women in labor before cesarean delivery (8.1% compared with 13.8%; RR 0.52, 95% CI 0.28-0.97; four studies, 440 participants) or those with ruptured membranes (4.3% compared with 20.1%; RR 0.23, 95% CI 0.10-0.52; three studies, 272 participants). Vaginal cleansing immediately before cesarean delivery in women in labor and in women with ruptured membranes reduces the risk of postoperative endometritis. Because it is generally inexpensive and a simple intervention, we recommend preoperative vaginal preparation before cesarean delivery in these women with sponge stick preparation of povidone-iodine 10% for at least 30 seconds. More data are needed to assess whether this intervention may be also useful for cesarean deliveries performed in women not in labor and for those without ruptured membranes. PROSPERO International prospective register of systematic reviews, https://www.crd.york.ac.uk/PROSPERO/, CRD42017054843.

Hot Speech and Exploding Bombs: Autonomic Arousal During Emotion Classification of Prosodic Utterances and Affective Sounds

PubMed Central

Jürgens, Rebecca; Fischer, Julia; Schacht, Annekathrin

2018-01-01

Emotional expressions provide strong signals in social interactions and can function as emotion inducers in a perceiver. Although speech provides one of the most important channels for human communication, its physiological correlates, such as activations of the autonomous nervous system (ANS) while listening to spoken utterances, have received far less attention than in other domains of emotion processing. Our study aimed at filling this gap by investigating autonomic activation in response to spoken utterances that were embedded into larger semantic contexts. Emotional salience was manipulated by providing information on alleged speaker similarity. We compared these autonomic responses to activations triggered by affective sounds, such as exploding bombs, and applause. These sounds had been rated and validated as being either positive, negative, or neutral. As physiological markers of ANS activity, we recorded skin conductance responses (SCRs) and changes of pupil size while participants classified both prosodic and sound stimuli according to their hedonic valence. As expected, affective sounds elicited increased arousal in the receiver, as reflected in increased SCR and pupil size. In contrast, SCRs to angry and joyful prosodic expressions did not differ from responses to neutral ones. Pupil size, however, was modulated by affective prosodic utterances, with increased dilations for angry and joyful compared to neutral prosody, although the similarity manipulation had no effect. These results indicate that cues provided by emotional prosody in spoken semantically neutral utterances might be too subtle to trigger SCR, although variation in pupil size indicated the salience of stimulus variation. Our findings further demonstrate a functional dissociation between pupil dilation and skin conductance that presumably origins from their differential innervation. PMID:29541045

Do Listeners Store in Memory a Speaker's Habitual Utterance-Final Phonation Type?

PubMed Central

Bőhm, Tamás; Shattuck-Hufnagel, Stefanie

2009-01-01

Earlier studies report systematic differences across speakers in the occurrence of utterance-final irregular phonation; the work reported here investigated whether human listeners remember this speaker-specific information and can access it when necessary (a prerequisite for using this cue in speaker recognition). Listeners personally familiar with the voices of the speakers were presented with pairs of speech samples: one with the original and the other with transformed final phonation type. Asked to select the member of the pair that was closer to the talker's voice, most listeners tended to choose the unmanipulated token (even though they judged them to sound essentially equally natural). This suggests that utterance-final pitch period irregularity is part of the mental representation of individual speaker voices, although this may depend on the individual speaker and listener to some extent. PMID:19776665

Hierarchy of conversational rule violations involving utterance-based augmentative and alternative communication systems.

PubMed

Hoag, Linda A; Bedrosian, Jan L; McCoy, Kathleen F; Johnson, Dallas E

2008-01-01

This study examined the effects of using messages with conversational rule violations on attitudes toward people who used utterance-based augmentative and alternative communication (AAC) systems in transactional interactions. Specifically, the ratings were compared across messages with relevance, informativeness, and brevity violations, when latency remained constant (i.e., short). The 96 participating sales clerks viewed scripted, videotaped bookstore conversations and completed an attitude questionnaire. Results indicated that the prestored message with repeated words/phrases was rated the highest, followed by the message with excessive information; next was the message with inadequate information, followed by the message with partly relevant information. The findings may be useful to those using utterance-based systems when making message choices during interactions with service providers. Technological implications point to the development of schema/script-based systems and intelligent editing.

"Mommy, You Are the Princess and I Am the Queen": How Preschool Children's Initiation and Language Use during Pretend Play Relate to Complexity

ERIC Educational Resources Information Center

Melzer, Dawn K.; Palermo, Cori A.

2016-01-01

The present study investigated the relationship between complexity of pretend play, initiation of pretense activities, and mental state utterances used during play. Children 3 to 4 years of age were videotaped while engaging in pretend play with a parent. The videotapes were coded according to mental state utterances (i.e. desire, emotion,…

Linguistic Knowledge at Early Stage I; Evidence from Successive Single Word Utterances. Papers and Reports on Child Language Development, No. 12.

ERIC Educational Resources Information Center

Horgan, Dianne

A study was conducted to determine whether the child expresses linguistic knowledge during the single-word period. The order of mention in 65 sets of successive single-word utterances from five children at Stage 1, two to four years old, were analyzed. To elicit speech, the children were shown line drawings representing such situations as animate…

A Semantic-Relational-Concepts Based Theory of Language Acquisition as Applied to Down's Syndrome Children: Implication for a Language Enhancement Program. Research Report No. 62.

ERIC Educational Resources Information Center

Buium, Nissan; And Others

Speech samples were collected from three 48-month-old children with Down's Syndrome over an 11-month period after Ss had reached the one word utterance stage. Each S's linguistic utterances were semantically evaluated in terms of M. Bowerman's, R. Brown's, and I. Schlesinger's semantic relational concepts. Generally, findings suggested that Ss…

The Use of Presupposition in the Creation of Socio-Political Dominance in Kenyan Parliamentary Debates between 1992 and 2010

ERIC Educational Resources Information Center

Peter, Christine Atieno; Mukuthuria, Mwenda; Muriung, Peter

2016-01-01

Presupposition, a linguistic element can be employed in utterances. When this is done it enhances the comprehension of what is being communicated. This aspect of language that is implicit assumption of an utterance is a strategy that may be used to express a speaker's socio-political dominance. The truth of what is said is taken for granted and…

Data Selection for Within-Class Covariance Estimation

DTIC Science & Technology

2016-09-08

recognition performance. While developers have typically exploited the vast archive of speaker labeled data available from earlier NIST evaluations...utterances from a large population of speakers. Fortunately, participants in NIST evaluations have access to a vast repository of legacy data from earlier...previous NIST evaluations. Training data for the UBM and T-matrix was obtained from the NIST Switchboard 2 phases 2-5 [12] and SRE04/05/06 utterances

Data Selection for Within-Class Covariance Estimation

DTIC Science & Technology

2016-09-08

NIST evaluations to train the within- class and across-class covariance matrices required by these techniques, little attention has been paid to the...multiple utterances from a large population of speakers. Fortunately, participants in NIST evaluations have access to a repository of legacy data from...utterances chosen from previous NIST evaluations. Training data for the UBM and T-matrix was obtained from the NIST Switchboard 2 phases 2-5 and

Sound representation in higher language areas during language generation

PubMed Central

Magrassi, Lorenzo; Aromataris, Giuseppe; Cabrini, Alessandro; Annovazzi-Lodi, Valerio; Moro, Andrea

2015-01-01

How language is encoded by neural activity in the higher-level language areas of humans is still largely unknown. We investigated whether the electrophysiological activity of Broca’s area correlates with the sound of the utterances produced. During speech perception, the electric cortical activity of the auditory areas correlates with the sound envelope of the utterances. In our experiment, we compared the electrocorticogram recorded during awake neurosurgical operations in Broca’s area and in the dominant temporal lobe with the sound envelope of single words versus sentences read aloud or mentally by the patients. Our results indicate that the electrocorticogram correlates with the sound envelope of the utterances, starting before any sound is produced and even in the absence of speech, when the patient is reading mentally. No correlations were found when the electrocorticogram was recorded in the superior parietal gyrus, an area not directly involved in language generation, or in Broca’s area when the participants were executing a repetitive motor task, which did not include any linguistic content, with their dominant hand. The distribution of suprathreshold correlations across frequencies of cortical activities varied whether the sound envelope derived from words or sentences. Our results suggest the activity of language areas is organized by sound when language is generated before any utterance is produced or heard. PMID:25624479

A Systemic Functional Linguistic Analysis of the Utterances of Three South African Physical Sciences Teachers

NASA Astrophysics Data System (ADS)

Jawahar, Kavish; Dempster, Edith R.

2013-06-01

In this study, the sociocultural view of science as a language and some quantitative language features of the complementary theoretical framework of systemic functional linguistics are employed to analyse the utterances of three South African Physical Sciences teachers. Using a multi-case study methodology, this study provides a sophisticated description of the utterances of Pietermaritzburg Physical Sciences teachers in language contexts characterised by varying proportions of English Second Language (ESL) students in each class. The results reveal that, as expected, lexical cohesion as measured by the cohesive harmony index and proportion of repeated content words relative to total words, increased with an increasing proportion of ESL students. However, the use of nominalisation by the teachers and the lexical density of their utterances did not decrease with an increasing proportion of ESL students. Furthermore, the results reveal that each individual Physical Sciences teacher had a 'signature' talk, unrelated to the language context in which they taught. This study signals the urgent and critical need for South African science teacher training programmes to place a greater emphasis on the functional use of language for different language contexts in order to empower South African Physical Sciences teachers to adequately apprentice their students into the use of the register of scientific English.

Improving communication in general practice when mental health issues appear: piloting a set of six evidence-based skills.

PubMed

Stensrud, Tonje Lauritzen; Gulbrandsen, Pål; Mjaaland, Trond Arne; Skretting, Sidsel; Finset, Arnstein

2014-04-01

To test a communication skills training program teaching general practitioners (GPs) a set of six evidence-based mental health related skills. A training program was developed and tested in a pilot test-retest study with 21 GPs. Consultations were videotaped and actors used as patients. A coding scheme was created to assess the effect of training on GP behavior. Relevant utterances were categorized as examples of each of the six specified skills. The GPs' self-perceived learning needs and self-efficacy were measured with questionnaires. The mean number of GP utterances related to the six skills increased from 13.3 (SD 6.2) utterances before to 23.6 (SD 7.2) utterances after training; an increase of 77.4% (P<0.001). Effect sizes varied from 0.23 to 1.37. Skills exploring emotions, cognitions and resources, and the skill Promote coping, increased significantly. Self-perceived learning needs and self-efficacy did not change significantly. The results from this pilot test are encouraging. GPs enhanced their use on four out of six mental health related communication skills significantly, and the effects were medium to large. This training approach appears to be an efficacious approach to mental health related communication skills training in general practice. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Development of speech motor control: lip movement variability.

PubMed

Schötz, Susanne; Frid, Johan; Löfqvist, Anders

2013-06-01

This study examined variability of lip movements across repetitions of the same utterance as a function of age in Swedish speakers. The specific purpose was to extend earlier findings by examining variability in both phase and amplitude. Subjects were 50 typically developed native Swedish children and adults (28 females, 22 males, aged 5 to 31 yr). Lip movements were recorded during 15 to 20 repetitions of a short Swedish phrase using three-dimensional articulography. After correction for head movements, the kinematic records were expressed in a maxilla-based coordinate system. Movement onset and offset of the utterance were identified using kinematic landmarks. The Euclidean distance between receivers on the upper and lower lips was calculated and subjected to functional data analysis to assess both phase and amplitude variability. Results show a decrease in both indices as a function of age, with a greater reduction of amplitude variability. There was no difference between males and females for either index. The two indices were moderately correlated with each other, suggesting that they capture different aspects of speech production. Utterance duration also decreased with age, but variability was unrelated to duration. The standard deviation of utterance duration also decreased with age. The present results thus suggest that age related changes in speech motor control continue up until 30 years of age.

Can a model of overlapping gestures account for scanning speech patterns?

PubMed

Tjaden, K

1999-06-01

A simple acoustic model of overlapping, sliding gestures was used to evaluate whether coproduction was reduced for neurologic speakers with scanning speech patterns. F2 onset frequency was used as an acoustic measure of coproduction or gesture overlap. The effects of speaking rate (habitual versus fast) and utterance position (initial versus medial) on F2 frequency, and presumably gesture overlap, were examined. Regression analyses also were used to evaluate the extent to which across-repetition temporal variability in F2 trajectories could be explained as variation in coproduction for consonants and vowels. The lower F2 onset frequencies for disordered speakers suggested that gesture overlap was reduced for neurologic individuals with scanning speech. Speaking rate change did not influence F2 onset frequencies, and presumably gesture overlap, for healthy or disordered speakers. F2 onset frequency differences for utterance-initial and -medial repetitions were interpreted to suggest reduced coproduction for the utterance-initial position. The utterance-position effects on F2 onset frequency, however, likely were complicated by position-related differences in articulatory scaling. The results of the regression analysis indicated that gesture sliding accounts, in part, for temporal variability in F2 trajectories. Taken together, the results of this study provide support for the idea that speech production theory for healthy talkers helps to account for disordered speech production.

Wind-Tunnel Tests of Air Inlet and Outlet Openings on a Streamline Body

DTIC Science & Technology

1940-11-01

e. , ko :3,%me 9_s +h.o stat- e -orossu_re of _’ ._c%_rn:zl "".: ._ ,_.ac o ,., zio;7 in the vicinit?r of the 0ooni_=.o _._., _.c.di _’:,._.......] ch...m!ine b,-’,,.d’_; were carr’.ed to 4:50 nJ.!es _qer Ko -Qr. ’_he t __%_ O? %x.:(" 0. .... __ _S were gtu o_:. ,-r:: oil _ _r miles per b.c_ro Th:’s...8217c,.’_u41:L:’zc; bo a’_ dis- - trib_._tion,, 0_0..-.,:.5_ ts.e :.7o:_’.:r,_:,r& . ........ :-or of ’ sko >qd::" zo r_orc- _’_C;.,’_.D0C]’"̂ .. _3

Association of long-term PM2.5 exposure with mortality using different air pollution exposure models: impacts in rural and urban California.

PubMed

Garcia, Cynthia A; Yap, Poh-Sin; Park, Hye-Youn; Weller, Barbara L

2016-01-01

Most PM2.5-associated mortality studies are not conducted in rural areas where mortality rates may differ when population characteristics, health care access, and PM2.5 composition differ. PM2.5-associated mortality was investigated in the elderly residing in rural-urban zip codes. Exposure (2000-2006) was estimated using different models and Poisson regression was performed using 2006 mortality data. PM2.5 models estimated comparable exposures, although subtle differences were observed in rate ratios (RR) within areas by health outcomes. Cardiovascular disease (CVD), ischemic heart disease (IHD), and cardiopulmonary disease (CPD), mortality was significantly associated with rural, urban, and statewide chronic PM2.5 exposures. We observed larger effect sizes in RRs for CVD, CPD, and all-cause (AC) with similar sizes for IHD mortality in rural areas compared to urban areas. PM2.5 was significantly associated with AC mortality in rural areas and statewide; however, in urban areas, only the most restrictive exposure model showed an association. Given the results seen, future mortality studies should consider adjusting for differences with rural-urban variables.

Avoiding full corrections in dynamic SPECT images impacts the performance of SPECT myocardial blood flow quantitation.

PubMed

Wang, Lei; Wu, Dayong; Yang, Yong; Chen, Ing-Jou; Lin, Chih-Yuan; Hsu, Bailing; Fang, Wei; Tang, Yi-Da

2017-08-01

This study investigated the performance of SPECT myocardial blood flow (MBF) quantitation lacking full physical corrections (All Corr) in dynamic SPECT (DySPECT) images. Eleven healthy normal volunteers (HVT) and twenty-four patients with angiography-documented CAD were assessed. All Corr in 99m Tc-sestamibi DySPECT encompassed noise reduction (NR), resolution recovery (RR), and corrections for scatter (SC) and attenuation (AC), otherwise no correction (NC) or only partial corrections. The performance was evaluated by quality index (R 2 ) and blood-pool spillover index (FBV) in kinetic modeling, and by rest flow (RMBF) and stress flow (SMBF) compared with those of All Corr. In HVT group, NC diminished 2-fold flow uniformity with the most degraded quality (15%-18% reduced R 2 ) and elevated spillover effect (45%-50% increased FBV). Consistently higher RMBF and SMBF were discovered in both groups (HVT 1.54/2.31 higher; CAD 1.60/1.72; all P < .0001). Bland-Altman analysis revealed positive flow bias (HVT 0.9-2.6 mL/min/g; CAD 0.7-1.3) with wide ranges of 95% CI of agreement (HVT NC -1.9-7.1; NR -0.4-4.4; NR + SC -1.1-4.3; NR + SC + RR -0.7-2.5) (CAD NC -1.2-3.8; NR -1.0-2.8; NR + SC -1.0-2.5; NR + SC + RR -1.1-2.6). Uncorrected physical interference in DySPECT images can extensively impact the performance of MBF quantitation. Full physical corrections should be considered to warrant this tool for clinical utilization.

Chinese herbal medicine Dengzhan Xixin injection for acute ischemic stroke: A systematic review and meta-analysis of randomised controlled trials.

PubMed

Li, Jin-Gen; Wang, Li-Qiong; Yang, Xiao-Ying; Chen, Zhuo; Lai, Lily Y W; Xu, Hao; Liu, Jian-Ping

2017-10-01

To evaluate the effectiveness and safety of Chinese herbal medicine Dengzhan Xixin (Erigeron breviscapus) injection for acute ischemic stroke. Systematic review and meta-analysis (CRD42016038413, http://www.crd.york.ac.uk/PROSPERO). Six electronic databases were searched from inception to March 2016 for randomised controlled trials (RCTs) of Dengzhan Xixin (DZXX) injection for acute ischemic stroke. The methodological quality of RCTs was assessed by the Cochrane risk of bias tool. was performed using RevMan 5.3 and was presented with mean difference (MD) or relative risk (RR) and their 95% confidence interval (CI). A summary of finding table was generated by GRADEpro (version 3.6). Twenty-five RCTs with 2498 participants were included and all trials adopted conventional therapy (CT) in both arms. Most of the studies had high risk of bias. The addition of DZXX to CT showed no significant benefit on death (RR 0.27, 95% CI 0.05-1.63) within the treatment period (14-35 d), but showed higher Barthel index score (MD 10.20, 95% CI 8.16-12.25), lower neurological function deficit score (MD -3.99, 95% CI -5.68 to -2.30, by NFDS; MD -1.67, 95% CI -2.59 to -0.76, by NIHSS), and lower treatment failure (RR 0.40, 95% CI 0.31-0.52). Thirteen trials (52%) reported the outcome of adverse events, but no serious adverse events were reported. Low quality evidence implied that DZXX injection appeared to improve neurological function in patients with acute ischemic stroke. However, this potential benefit should be further studied in large, rigorous trials. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Effectiveness of the High-Tech Speech-Generating Device with Proloquo2Go App in Reducing Echolalia Utterances in a Student with Autism

ERIC Educational Resources Information Center

Alrusayni, Norah

2017-01-01

This study was conducted to determine the effectiveness of using the high-tech speech-generating device with Proloquo2Go app to reduce echolalic utterances in a student with autism during conversational speech. After observing that the iPad device with several apps was used by the students and that it served as a communication device, language…

The intonation of gapping and coordination in Japanese: evidence for intonational phrase and utterance.

PubMed

Kawahara, Shigeto; Shinya, Takahito

2008-01-01

In previous studies of Japanese intonational phonology, levels of prosodic constituents above the Major Phrase have not received much attention. This paper argues that at least two prosodic levels exist above the Major Phrase in Japanese. Through a detailed investigation of the intonation of gapping and coordination in Japanese, we argue that each syntactic clause projects its own Intonational Phrase, while an entire sentence constitutes one Utterance. We show that the Intonational Phrase is characterized by tonal lowering, creakiness and a pause in final position, as well as a distinctive large initial rise and pitch reset at its beginning. The Utterance defines a domain of declination, and it is signaled by an even larger initial rise, as well as a phrasal H tone at its right edge. Building on our empirical findings, we discuss several implications for the theory of intonational phonology. (c) 2007 S. Karger AG, Basel.

The Developmental Progression of Understanding of Mind during a Hiding Game

PubMed Central

Nelson, P. Brooke; Adamson, Lauren B.; Bakeman, Roger

2011-01-01

In this longitudinal study, 52 typically developing preschoolers engaged in a hiding game with their mothers when children were 42-, 54-, and 66-months old. Children's understanding of mind, positive affect, and engagement with the task were rated, and mothers' utterances were coded for role and content. Analyses confirmed that some facets of children's understanding of mind developed sequentially; specifically, they expressed an understanding of knowledge access before an understanding of deception and false beliefs, and expressed an understanding of deception before an understanding of false beliefs. Children's understanding of mind increased across visits and positively correlated with false belief task performance. Results suggest that mothers may tailor the content of their utterances to the child's growing expertise, but the role of mothers' utterances did not change. Observing preschoolers engaged in a playful hiding game revealed that children's understanding of mind not only increased with age but also developed sequentially. PMID:25960610

Children's acquisition of nouns and verbs in Italian: contrasting the roles of frequency and positional salience in maternal language.

PubMed

Longobardi, Emiddia; Rossi-Arnaud, Clelia; Spataro, Pietro; Putnick, Diane L; Bornstein, Marc H

2015-01-01

Because of its structural characteristics, specifically the prevalence of verb types in infant-directed speech and frequent pronoun-dropping, the Italian language offers an attractive opportunity to investigate the predictive effects of input frequency and positional salience on children's acquisition of nouns and verbs. We examined this issue in a sample of twenty-six mother-child dyads whose spontaneous conversations were recorded, transcribed, and coded at 1;4 and 1;8. The percentages of nouns occurring in the final position of maternal utterances at 1;4 predicted children's production of noun types at 1;8. For verbs, children's growth rates were positively predicted by the percentages of input verbs occurring in utterance-initial position, but negatively predicted by the percentages of verbs located in the final position of maternal utterances at 1;4. These findings clearly illustrate that the effects of positional salience vary across lexical categories.

Perceptual congruency of audio-visual speech affects ventriloquism with bilateral visual stimuli.

PubMed

Kanaya, Shoko; Yokosawa, Kazuhiko

2011-02-01

Many studies on multisensory processes have focused on performance in simplified experimental situations, with a single stimulus in each sensory modality. However, these results cannot necessarily be applied to explain our perceptual behavior in natural scenes where various signals exist within one sensory modality. We investigated the role of audio-visual syllable congruency on participants' auditory localization bias or the ventriloquism effect using spoken utterances and two videos of a talking face. Salience of facial movements was also manipulated. Results indicated that more salient visual utterances attracted participants' auditory localization. Congruent pairing of audio-visual utterances elicited greater localization bias than incongruent pairing, while previous studies have reported little dependency on the reality of stimuli in ventriloquism. Moreover, audio-visual illusory congruency, owing to the McGurk effect, caused substantial visual interference on auditory localization. Multisensory performance appears more flexible and adaptive in this complex environment than in previous studies.

How do children acquire early grammar and build multiword utterances? A corpus study of French children aged 2 to 4.

PubMed

Le Normand, M T; Moreno-Torres, I; Parisse, C; Dellatolas, G

2013-01-01

In the last 50 years, researchers have debated over the lexical or grammatical nature of children's early multiword utterances. Due to methodological limitations, the issue remains controversial. This corpus study explores the effect of grammatical, lexical, and pragmatic categories on mean length of utterances (MLU). A total of 312 speech samples from high-low socioeconomic status (SES) French-speaking children aged 2-4 years were annotated with a part-of-speech-tagger. Multiple regression analyses show that grammatical categories, particularly the most frequent subcategories, were the best predictors of MLU both across age and SES groups. These findings support the view that early language learning is guided by grammatical rather than by lexical words. This corpus research design can be used for future cross-linguistic and cross-pathology studies. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

Lexically-based learning and early grammatical development.

PubMed

Lieven, E V; Pine, J M; Baldwin, G

1997-02-01

Pine & Lieven (1993) suggest that a lexically-based positional analysis can account for the structure of a considerable proportion of children's early multiword corpora. The present study tests this claim on a second, larger sample of eleven children aged between 1;0 and 3;0 from a different social background, and extends the analysis to later in development. Results indicate that the positional analysis can account for a mean of 60% of all the children's multiword utterances and that the great majority of all other utterances are defined as frozen by the analysis. Alternative explanations of the data based on hypothesizing underlying syntactic or semantic relations are investigated through analyses of pronoun case marking and of verbs with prototypical agent-patient roles. Neither supports the view that the children's utterances are being produced on the basis of general underlying rules and categories. The implications of widespread distributional learning in early language development are discussed.

Assessment of pharmacy students' communication competence using the Roter Interaction Analysis System during objective structured clinical examinations.

PubMed

Kubota, Yoshie; Yano, Yoshitaka; Seki, Susumu; Takada, Kaori; Sakuma, Mio; Morimoto, Takeshi; Akaike, Akinori; Hiraide, Atsushi

2011-04-11

To determine the value of using the Roter Interaction Analysis System during objective structured clinical examinations (OSCEs) to assess pharmacy students' communication competence. As pharmacy students completed a clinical OSCE involving an interview with a simulated patient, 3 experts used a global rating scale to assess students' overall performance in the interview, and both the student's and patient's languages were coded using the Roter Interaction Analysis System (RIAS). The coders recorded the number of utterances (ie, units of spoken language) in each RIAS category. Correlations between the raters' scores and the number and types of utterances were examined. There was a significant correlation between students' global rating scores on the OSCE and the number of utterances in the RIAS socio-emotional category but not the RIAS business category. The RIAS proved to be a useful tool for assessing the socio-emotional aspect of students' interview skills.

Fricative-stop coarticulation: acoustic and perceptual evidence.

PubMed

Repp, B H; Mann, V A

1982-06-01

Eight native speakers of American English each produced ten tokens of all possible CV, FCV, and VFCV utterances with V = [a] or [u], F = [s] or [integral of], and C = [t] or [k]. Acoustic analysis showed that the formant transition onsets following the stop consonant release were systematically influenced by the preceding fricative, although there were large individual differences. In particular, F3 and F4 tended to be higher following [s] than following [integral of]. The coarticulatory effects were equally large in FCV (e.g.,/sta/) and VFCV (e.g.,/asda/) utterances; that is, they were not reduced when a syllable boundary intervened between fricative and stop. In a parallel perceptual study, the CV portions of these utterances (with release bursts removed to provoke errors) were presented to listeners for identification of the stop consonant. The pattern of place-of-articulation confusions, too, revealed coarticulatory effects due to the excised fricative context.

Talker's voice and gender stereotype in human auditory sentence processing--evidence from event-related brain potentials.

PubMed

Lattner, Sonja; Friederici, Angela D

2003-03-27

The present study investigated the influence of implicit speaker information on the sentence interpretation. We auditorily presented sentences that comprised of either stereotypically male or stereotypically female self-referent utterances. In the congruent conditions, these utterances were produced by speakers whose gender matched the semantic content. In the incongruent condition, stereotypically male utterances were produced by female speakers and vice versa. The event-related brain potentials (ERP) of 32 listeners exhibited a late positivity (P600) for the incongruent condition. No significant differences were observed between male and female listeners. In the absence of any ERP effect in the earlier time range, it was concluded that the access of the semantic information as such is independent of the speaker's voice, but that speaker property, semantic content and stereotypical knowledge are integrated in a later processing stage.

Do Gestures Pave the Way?: A Systematic Review of the Transitional Role of Gesture during the Acquisition of Early Lexical and Syntactic Milestones in Young Children with Down Syndrome

ERIC Educational Resources Information Center

te Kaat-van den Os, Danielle J. A.; Jongmans, Marian J.; Volman, M (Chiel) J. M.; Lauteslager, Peter E. M.

2015-01-01

Expressive language problems are common among children with Down syndrome (DS). In typically developing (TD) children, gestures play an important role in supporting the transition from one-word utterances to two-word utterances. As far as we know, an overview on the role of gestures to support expressive language development in children with DS is…

Being "in" or "out" of the game: subjective and acoustic reactions to exclusion and popularity in social anxiety.

PubMed

Gilboa-Schechtman, Eva; Galili, Lior; Sahar, Yair; Amir, Ofer

2014-01-01

Social Anxiety (SA) has been shown to be associated with compensatory deficits in pro-social behavior following exclusion and with failure to capitalize on social success. We assessed the subjective and expressive responses of high (n = 48) and low (n = 56) socially anxious individuals to exclusion, acceptance, and popularity induced by a participation in an online ball-tossing game. Before the manipulation, participants read aloud neutral and command utterances. Following the manipulation, participants rated their mood and cognitions and re-read the utterances. Acoustic properties (fundamental frequency-mF0, vocal intensity) of these utterances were analyzed. We found greater differences in self-esteem between high and low socially anxious individuals following the exclusion condition, as compared to the acceptance condition. Among low socially anxious individuals, exclusion promoted increased vocal confidence, as indicated by decreased mF0 and increased vocal intensity in uttering commands; High socially anxious individuals exhibited an opposite reaction, responding to exclusion by decreased vocal confidence. Following popularity, high SA was associated with decreased enhancement in mood and self-esteem in women but not in men. Consistent with evolutionary and interpersonal accounts of SA, we highlight the importance of examining the effects of SA and gender on events indicating unambiguous and unanimous social acceptance. Examining reactivity to changes in belongingness may have important implications for understanding the core mechanisms of SA.

Teacher knowledge and discourse control: Quantitative evidence from novice biology teachers' classrooms

NASA Astrophysics Data System (ADS)

Carlsen, William S.

This article describes the effects of science teacher subject-matter knowledge on classroom discourse at the level of individual utterances. It details one of three parallel analyses conducted in a year-long study of language in the classrooms of four new biology teachers. The conceptual framework of the study predicts that when teaching unfamiliar subject matter, teachers use a variety of discourse strategies to constrain student talk to a narrowly circumscribed topic domain. This article includes the results of an utterance-by-utterance analysis of teacher and student talk in a 30-lesson sample of science instruction. Data are broken down by classroom activity (e.g., lecture, laboratory, group work) for several measures, including mean duration of utterances, domination of the speaking floor by the teacher, frequency of teacher questioning, cognitive level of teacher questions, and student verbal participation. When teaching unfamiliar topics, the four teachers in this study tended to talk more often and for longer periods of time, ask questions frequently, and rely heavily on low cognitive level questions. The rate of student questions to the teacher varied with classroom activity. In common classroom communicative settings, student questions were less common when the teacher was teaching unfamiliar subject matter. The implications of these findings include a suggestion that teacher knowledge may be an important unconsidered variable in research on the cognitive level of questions and teacher wait-time.

Open Microphone Speech Understanding: Correct Discrimination Of In Domain Speech

NASA Technical Reports Server (NTRS)

Hieronymus, James; Aist, Greg; Dowding, John

2006-01-01

An ideal spoken dialogue system listens continually and determines which utterances were spoken to it, understands them and responds appropriately while ignoring the rest This paper outlines a simple method for achieving this goal which involves trading a slightly higher false rejection rate of in domain utterances for a higher correct rejection rate of Out of Domain (OOD) utterances. The system recognizes semantic entities specified by a unification grammar which is specialized by Explanation Based Learning (EBL). so that it only uses rules which are seen in the training data. The resulting grammar has probabilities assigned to each construct so that overgeneralizations are not a problem. The resulting system only recognizes utterances which reduce to a valid logical form which has meaning for the system and rejects the rest. A class N-gram grammar has been trained on the same training data. This system gives good recognition performance and offers good Out of Domain discrimination when combined with the semantic analysis. The resulting systems were tested on a Space Station Robot Dialogue Speech Database and a subset of the OGI conversational speech database. Both systems run in real time on a PC laptop and the present performance allows continuous listening with an acceptably low false acceptance rate. This type of open microphone system has been used in the Clarissa procedure reading and navigation spoken dialogue system which is being tested on the International Space Station.

Being “in” or “out” of the game: subjective and acoustic reactions to exclusion and popularity in social anxiety

PubMed Central

Gilboa-Schechtman, Eva; Galili, Lior; Sahar, Yair; Amir, Ofer

2014-01-01

Social Anxiety (SA) has been shown to be associated with compensatory deficits in pro-social behavior following exclusion and with failure to capitalize on social success. We assessed the subjective and expressive responses of high (n = 48) and low (n = 56) socially anxious individuals to exclusion, acceptance, and popularity induced by a participation in an online ball-tossing game. Before the manipulation, participants read aloud neutral and command utterances. Following the manipulation, participants rated their mood and cognitions and re-read the utterances. Acoustic properties (fundamental frequency–mF0, vocal intensity) of these utterances were analyzed. We found greater differences in self-esteem between high and low socially anxious individuals following the exclusion condition, as compared to the acceptance condition. Among low socially anxious individuals, exclusion promoted increased vocal confidence, as indicated by decreased mF0 and increased vocal intensity in uttering commands; High socially anxious individuals exhibited an opposite reaction, responding to exclusion by decreased vocal confidence. Following popularity, high SA was associated with decreased enhancement in mood and self-esteem in women but not in men. Consistent with evolutionary and interpersonal accounts of SA, we highlight the importance of examining the effects of SA and gender on events indicating unambiguous and unanimous social acceptance. Examining reactivity to changes in belongingness may have important implications for understanding the core mechanisms of SA. PMID:24672463

Student-patient communication during physical examination.

PubMed

Cleland, Jennifer; de la Croix, Anne; Cotton, Philip; Coull, Sharon; Skelton, John

2013-04-01

Communication during the physical examination has been understudied. Explicit, evidence-based guidance is not available as to the most effective content or process of communication while performing physical examination, or indeed how to teach this to medical students. The objective of this exploratory study was to explore how medical students communicate with patients when performing a physical examination in the absence of formal teaching on how to communicate in this situation. We recorded 15 senior UK medical students as they performed physical examinations with real patients in general practice situations. The transcriptions were analysed for linguistic functions to identify the use of different categories of utterances. Student utterances fell into four categories: minimising language; using positive evaluative language; repeating the patient; and stating intentions or explanations and requesting consent. Students would often preface an explanation or action by phrases showing 'togetherness', by using 'we' rather than 'you'. They also used linguistic 'hedges' to minimise the impact of an utterance. Senior medical students speak very little during the physical examination. When they do, they use a taxonomy of utterances that reflects those reported in doctor-patient interactions. Identifying how medical students communicate when carrying out the physical examination is the first step in planning how to best teach specific communication skills. Further work is needed to identify how best to explore communication during physical examination, and how this is taught and learned. © Blackwell Publishing Ltd 2013.

Acquisition of locative utterances in Norwegian: structure-building via lexical learning.

PubMed

Mitrofanova, Natalia; Westergaard, Marit

2018-03-15

This paper focuses on the acquisition of locative prepositional phrases in L1 Norwegian. We report on two production experiments with children acquiring Norwegian as their first language and compare the results to similar experiments conducted with Russian children. The results of the experiments show that Norwegian children at age 2 regularly produce locative utterances lacking overt prepositions, with the rate of preposition omission decreasing significantly by age 3. Furthermore, our results suggest that phonologically strong and semantically unambiguous locative items appear earlier in Norwegian children's utterances than their phonologically weak and semantically ambiguous counterparts. This conclusion is confirmed by a corpus study. We argue that our results are best captured by the Underspecified P Hypothesis (UPH; Mitrofanova, 2017), which assumes that, at early stages of grammatical development, the underlying structure of locative utterances is underspecified, with more complex functional representations emerging gradually based on the input. This approach predicts that the rate of acquisition in the domain of locative PPs should be influenced by the lexical properties of individual language-specific grammatical elements (such as frequency, morphological complexity, phonological salience, or semantic ambiguity). Our data from child Norwegian show that this prediction is borne out. Specifically, the results of our study suggest that phonologically more salient and semantically unambiguous items are mastered earlier than their ambiguous and phonologically less salient counterparts, despite the higher frequency of the latter in the input (Clahsen et al., 1996).

A computational neural model of goal-directed utterance selection.

PubMed

Klein, Michael; Kamp, Hans; Palm, Guenther; Doya, Kenji

2010-06-01

It is generally agreed that much of human communication is motivated by extra-linguistic goals: we often make utterances in order to get others to do something, or to make them support our cause, or adopt our point of view, etc. However, thus far a computational foundation for this view on language use has been lacking. In this paper we propose such a foundation using Markov Decision Processes. We borrow computational components from the field of action selection and motor control, where a neurobiological basis of these components has been established. In particular, we make use of internal models (i.e., next-state transition functions defined on current state action pairs). The internal model is coupled with reinforcement learning of a value function that is used to assess the desirability of any state that utterances (as well as certain non-verbal actions) can bring about. This cognitive architecture is tested in a number of multi-agent game simulations. In these computational experiments an agent learns to predict the context-dependent effects of utterances by interacting with other agents that are already competent speakers. We show that the cognitive architecture can account for acquiring the capability of deciding when to speak in order to achieve a certain goal (instead of performing a non-verbal action or simply doing nothing), whom to address and what to say. Copyright 2010 Elsevier Ltd. All rights reserved.

Everyday conversation requires cognitive inference: neural bases of comprehending implicated meanings in conversations.

PubMed

Jang, Gijeong; Yoon, Shin-ae; Lee, Sung-Eun; Park, Haeil; Kim, Joohan; Ko, Jeong Hoon; Park, Hae-Jeong

2013-11-01

In ordinary conversations, literal meanings of an utterance are often quite different from implicated meanings and the inference about implicated meanings is essentially required for successful comprehension of the speaker's utterances. Inference of finding implicated meanings is based on the listener's assumption that the conversational partner says only relevant matters according to the maxim of relevance in Grice's theory of conversational implicature. To investigate the neural correlates of comprehending implicated meanings under the maxim of relevance, a total of 23 participants underwent an fMRI task with a series of conversational pairs, each consisting of a question and an answer. The experimental paradigm was composed of three conditions: explicit answers, moderately implicit answers, and highly implicit answers. Participants were asked to decide whether the answer to the Yes/No question meant 'Yes' or 'No'. Longer reaction time was required for the highly implicit answers than for the moderately implicit answers without affecting the accuracy. The fMRI results show that the left anterior temporal lobe, left angular gyrus, and left posterior middle temporal gyrus had stronger activation in both moderately and highly implicit conditions than in the explicit condition. Comprehension of highly implicit answers had increased activations in additional regions including the left inferior frontal gyrus, left medial prefrontal cortex, left posterior cingulate cortex and right anterior temporal lobe. The activation results indicate involvement of these regions in the inference process to build coherence between literally irrelevant but pragmatically associated utterances under the maxim of relevance. Especially, the left anterior temporal lobe showed high sensitivity to the level of implicitness and showed increased activation for highly versus moderately implicit conditions, which imply its central role in inference such as semantic integration. The right hemisphere activation, uniquely found in the anterior temporal lobe for highly implicit utterances, suggests its competence for integrating distant concepts in implied utterances under the relevance principle. Copyright © 2013 Elsevier Inc. All rights reserved.

Effects of disfluencies, predictability, and utterance position on word form variation in English conversation

NASA Astrophysics Data System (ADS)

Bell, Alan; Jurafsky, Daniel; Fosler-Lussier, Eric; Girand, Cynthia; Gregory, Michelle; Gildea, Daniel

2003-02-01

Function words, especially frequently occurring ones such as (the, that, and, and of ), vary widely in pronunciation. Understanding this variation is essential both for cognitive modeling of lexical production and for computer speech recognition and synthesis. This study investigates which factors affect the forms of function words, especially whether they have a fuller pronunciation (e.g., edh,eye, edh,æ,tee, æ,en,&dee, vee) or a more reduced or lenited pronunciation (e.g., edh,schwa, edh,bari;t, n, schwa). It is based on over 8000 occurrences of the ten most frequent English function words in a 4-h sample from conversations from the Switchboard corpus. Ordinary linear and logistic regression models were used to examine variation in the length of the words, in the form of their vowel (basic, full, or reduced), and whether final obstruents were present or not. For all these measures, after controlling for segmental context, rate of speech, and other important factors, there are strong independent effects that made high-frequency monosyllabic function words more likely to be longer or have a fuller form (1) when neighboring disfluencies (such as filled pauses uh and um) indicate that the speaker was encountering problems in planning the utterance; (2) when the word is unexpected, i.e., less predictable in context; (3) when the word is either utterance initial or utterance final. Looking at the phenomenon in a different way, frequent function words are more likely to be shorter and to have less-full forms in fluent speech, in predictable positions or multiword collocations, and utterance internally. Also considered are other factors such as sex (women are more likely to use fuller forms, even after controlling for rate of speech, for example), and some of the differences among the ten function words in their response to the factors.

Perceiving referential intent: Dynamics of reference in natural parent-child interactions

PubMed Central

Trueswell, John C.; Lin, Yi; Armstrong, Benjamin; Cartmill, Erica A.; Goldin-Meadow, Susan; Gleitman, Lila R.

2016-01-01

Two studies are presented which examined the temporal dynamics of the social-attentive behaviors that co-occur with referent identification during natural parent-child interactions in the home. Study 1 focused on 6.2 hours of videos of 56 parents interacting during everyday activities with their 14–18 month-olds, during which parents uttered common nouns as parts of spontaneously occurring utterances. Trained coders recorded, on a second-by-second basis, parent and child attentional behaviors relevant to reference in the period (40 sec.) immediately surrounding parental naming. The referential transparency of each interaction was independently assessed by having naïve adult participants guess what word the parent had uttered in these video segments, but with the audio turned off, forcing them to use only non-linguistic evidence available in the ongoing stream of events. We found a great deal of ambiguity in the input along with a few potent moments of word-referent transparency; these transparent moments have a particular temporal signature with respect to parent and child attentive behavior: it was the object’s appearance and/or the fact that it captured parent/child attention at the moment the word was uttered, not the presence of the object throughout the video, that predicted observers’ accuracy. Study 2 experimentally investigated the precision of the timing relation, and whether it has an effect on observer accuracy, by disrupting the timing between when the word was uttered and the behaviors present in the videos as they were originally recorded. Disrupting timing by only +/− 1 to 2 sec. reduced participant confidence and significantly decreased their accuracy in word identification. The results enhance an expanding literature on how dyadic attentional factors can influence early vocabulary growth. By hypothesis, this kind of time-sensitive data-selection process operates as a filter on input, removing many extraneous and ill-supported word-meaning hypotheses from consideration during children’s early vocabulary learning. PMID:26775159

Fabrication and investigation of photosensitive MoOx/n-CdTe heterojunctions

NASA Astrophysics Data System (ADS)

Solovan, M. M.; Gavaleshko, N. M.; Brus, V. V.; Mostovyi, A. I.; Maryanchuk, P. D.; Tresso, E.

2016-10-01

MoOx/n-CdTe photosensitive heterostructures were prepared by the deposition of molybdenum oxide thin films onto n-type single-crystal CdTe substrates by DC reactive magnetron sputtering. The obtained heterojunctions possessed sharply defined rectifying properties with the rectification ration RR ˜ 106. The temperature dependences of the height of the potential barrier and series resistance of the MoOx/CdTe heterojunctions were investigated. The dominating current transport mechanisms through the heterojunctions were determined at forward and reverse biases. The analysis of capacitance-voltage (C-V) characteristics, measured at different frequencies of the small amplitude AC signal and corrected by the effect of the series resistance, provided evidence of the presence of electrically charged interface states, which significantly affect the measured capacitance.

Genetic polymorphisms within exon 3 of heat shock protein 90AA1 gene and its association with heat tolerance traits in Sahiwal cows

PubMed Central

Kumar, Rakesh; Gupta, I. D.; Verma, Archana; Verma, Nishant; Vineeth, M. R.

2015-01-01

Aim: The present study was undertaken to identify novel single nucleotide polymorphism (SNP) in Exon 3 of HSP90AA1 gene and to analyze their association with respiration rate (RR) and rectal temperature (RT) in Sahiwal cows. Materials and Methods: The present study was carried out in Sahiwal cows (n=100) with the objectives to identify novel SNP in exon 3 of HSP90AA1 gene and to explore the association with heat tolerance traits. CLUSTAL-W multiple sequence analysis was used to identify novel SNPs in exon 3 of HSP90AA1 gene in Sahiwal cows. Gene and genotype frequencies of different genotypes were estimated by standard procedure POPGENE version 1.32 (University of Alberta, Canada). The significant effect of SNP variants on physiological parameters, e.g. RR and RT were analyzed using the General Linear model procedure of SAS Version 9.2. Results: The polymerase chain reaction product with the amplicon size of 450 bp was successfully amplified, covering exon 3 region of HSP90AA1 gene in Sahiwal cows. On the basis of comparative sequence analysis of Sahiwal samples (n=100), transitional mutations were detected at locus A1209G as compared to Bos taurus (NCBI GenBank AC_000178.1). After chromatogram analysis, three genotypes AA, AG, and GG with respective frequencies of 0.23, 0.50, and 0.27 ascertained. RR and RT were recorded once during probable extreme hours in winter, spring, and summer seasons. It was revealed that significant difference (p<0.01) among genetic variants of HSP90AA1 gene with heat tolerance trait was found in Sahiwal cattle. The homozygotic animals with AA genotype had lower heat tolerance coefficient (HTC) (1.78±0.04a), as compared to both AG and GG genotypes (1.85±0.03b and 1.91±0.02c), respectively. The gene and genotype frequencies for the locus A1209G were ascertained. Conclusions: Novel SNP was found at the A1209G position showed all possible three genotypes (homozygous and heterozygous). Temperature humidity index has a highly significant association with RR, RT, and HTC in all the seasons. Perusal of results across different seasons showed the significant (p<0.01) difference in RR, RT, and HTC among winter, spring, and summer seasons. Genetic association with heat tolerance traits reveals their importance as a potential genetic marker for heat tolerance traits in Sahiwal cows. PMID:27047179

Her Voice Lingers on and Her Memory Is Strategic: Effects of Gender on Directed Forgetting

PubMed Central

Yang, Hwajin; Yang, Sujin; Park, Giho

2013-01-01

The literature on directed forgetting has employed exclusively visual words. Thus, the potentially interesting aspects of a spoken utterance, which include not only vocal cues (e.g., prosody) but also the speaker and the listener, have been neglected. This study demonstrates that prosody alone does not influence directed-forgetting effects, while the sex of the speaker and the listener significantly modulate directed-forgetting effects for spoken utterances. Specifically, forgetting costs were attenuated for female-spoken items compared to male-spoken items, and forgetting benefits were eliminated among female listeners but not among male listeners. These results suggest that information conveyed in a female voice draws attention to its distinct perceptual attributes, thus interfering with retention of the semantic meaning, while female listeners' superior capacity for processing the surface features of spoken utterances may predispose them to spontaneously employ adaptive strategies to retain content information despite distraction by perceptual features. Our findings underscore the importance of sex differences when processing spoken messages in directed forgetting. PMID:23691141

Brain correlates of discourse processing: An fMRI investigation of irony and conventional metaphor comprehension

PubMed Central

Eviatar, Zohar; Just, Marcel Adam

2006-01-01

Higher levels of discourse processing evoke patterns of cognition and brain activation that extend beyond the literal comprehension of sentences. We used fMRI to examine brain activation patterns while 16 healthy participants read brief three-sentence stories that concluded with either a literal, metaphoric, or ironic sentence. The fMRI images acquired during the reading of the critical sentence revealed a selective response of the brain to the two types of nonliteral utterances. Metaphoric utterances resulted in significantly higher levels of activation in the left inferior frontal gyrus and in bilateral inferior temporal cortex than the literal and ironic utterances. Ironic statements resulted in significantly higher activation levels than literal statements in the right superior and middle temporal gyri, with metaphoric statements resulting in intermediate levels in these regions. The findings show differential hemispheric sensitivity to these aspects of figurative language, and are relevant to models of the functional cortical architecture of language processing in connected discourse. PMID:16806316

Finding the music of speech: Musical knowledge influences pitch processing in speech.

PubMed

Vanden Bosch der Nederlanden, Christina M; Hannon, Erin E; Snyder, Joel S

2015-10-01

Few studies comparing music and language processing have adequately controlled for low-level acoustical differences, making it unclear whether differences in music and language processing arise from domain-specific knowledge, acoustic characteristics, or both. We controlled acoustic characteristics by using the speech-to-song illusion, which often results in a perceptual transformation to song after several repetitions of an utterance. Participants performed a same-different pitch discrimination task for the initial repetition (heard as speech) and the final repetition (heard as song). Better detection was observed for pitch changes that violated rather than conformed to Western musical scale structure, but only when utterances transformed to song, indicating that music-specific pitch representations were activated and influenced perception. This shows that music-specific processes can be activated when an utterance is heard as song, suggesting that the high-level status of a stimulus as either language or music can be behaviorally dissociated from low-level acoustic factors. Copyright © 2015 Elsevier B.V. All rights reserved.

The Importance of Form in Skinner's Analysis of Verbal Behavior and a Further Step

PubMed Central

Vargas, E. A.

2013-01-01

A series of quotes from B. F. Skinner illustrates the importance of form in his analysis of verbal behavior. In that analysis, form plays an important part in contingency control. Form and function complement each other. Function, the array of variables that control a verbal utterance, dictates the meaning of a specified form; form, as stipulated by a verbal community, indicates that meaning. The mediational actions that shape verbal utterances do not necessarily encounter their controlling variables. These are inferred from the form of the verbal utterance. Form carries the burden of implied meaning and underscores the importance of the verbal community in the expression of all the forms of language. Skinner's analysis of verbal behavior and the importance of form within that analysis provides the foundation by which to investigate language. But a further step needs to be undertaken to examine and to explain the abstractions of language as an outcome of action at an aggregate level. PMID:23814376

Linear Classifier with Reject Option for the Detection of Vocal Fold Paralysis and Vocal Fold Edema

NASA Astrophysics Data System (ADS)

Kotropoulos, Constantine; Arce, Gonzalo R.

2009-12-01

Two distinct two-class pattern recognition problems are studied, namely, the detection of male subjects who are diagnosed with vocal fold paralysis against male subjects who are diagnosed as normal and the detection of female subjects who are suffering from vocal fold edema against female subjects who do not suffer from any voice pathology. To do so, utterances of the sustained vowel "ah" are employed from the Massachusetts Eye and Ear Infirmary database of disordered speech. Linear prediction coefficients extracted from the aforementioned utterances are used as features. The receiver operating characteristic curve of the linear classifier, that stems from the Bayes classifier when Gaussian class conditional probability density functions with equal covariance matrices are assumed, is derived. The optimal operating point of the linear classifier is specified with and without reject option. First results using utterances of the "rainbow passage" are also reported for completeness. The reject option is shown to yield statistically significant improvements in the accuracy of detecting the voice pathologies under study.

Assessment of Pharmacy Students' Communication Competence Using the Roter Interaction Analysis System During Objective Structured Clinical Examinations

PubMed Central

Kubota, Yoshie; Seki, Susumu; Takada, Kaori; Sakuma, Mio; Morimoto, Takeshi; Akaike, Akinori; Hiraide, Atsushi

2011-01-01

Objective To determine the value of using the Roter Interaction Analysis System during objective structured clinical examinations (OSCEs) to assess pharmacy students' communication competence. Methods As pharmacy students completed a clinical OSCE involving an interview with a simulated patient, 3 experts used a global rating scale to assess students' overall performance in the interview, and both the student's and patient's languages were coded using the Roter Interaction Analysis System (RIAS). The coders recorded the number of utterances (ie, units of spoken language) in each RIAS category. Correlations between the raters' scores and the number and types of utterances were examined. Results There was a significant correlation between students' global rating scores on the OSCE and the number of utterances in the RIAS socio-emotional category but not the RIAS business category. Conclusions The RIAS proved to be a useful tool for assessing the socio-emotional aspect of students' interview skills. PMID:21655397

Definition of (so MIScalled) ''Complexity'' as UTTER-SIMPLICITY!!! Versus Deviations From it as Complicatedness-Measure

NASA Astrophysics Data System (ADS)

Young, F.; Siegel, Edward Carl-Ludwig

2011-03-01

(so MIScalled) "complexity" with INHERENT BOTH SCALE-Invariance Symmetry-RESTORING, AND 1 / w (1.000..) "pink" Zipf-law Archimedes-HYPERBOLICITY INEVITABILITY power-spectrum power-law decay algebraicity. Their CONNECTION is via simple-calculus SCALE-Invariance Symmetry-RESTORING logarithm-function derivative: (d/ d ω) ln(ω) = 1 / ω , i.e. (d/ d ω) [SCALE-Invariance Symmetry-RESTORING](ω) = 1/ ω . Via Noether-theorem continuous-symmetries relation to conservation-laws: (d/ d ω) [inter-scale 4-current 4-div-ergence} = 0](ω) = 1 / ω . Hence (so MIScalled) "complexity" is information inter-scale conservation, in agreement with Anderson-Mandell [Fractals of Brain/Mind, G. Stamov ed.(1994)] experimental-psychology!!!], i.e. (so MIScalled) "complexity" is UTTER-SIMPLICITY!!! Versus COMPLICATEDNESS either PLUS (Additive) VS. TIMES (Multiplicative) COMPLICATIONS of various system-specifics. COMPLICATEDNESS-MEASURE DEVIATIONS FROM complexity's UTTER-SIMPLICITY!!!: EITHER [SCALE-Invariance Symmetry-BREAKING] MINUS [SCALE-Invariance Symmetry-RESTORING] via power-spectrum power-law algebraicity decays DIFFERENCES: ["red"-Pareto] MINUS ["pink"-Zipf Archimedes-HYPERBOLICITY INEVITABILITY]!!!

Language change in a multiple group society

NASA Astrophysics Data System (ADS)

Pop, Cristina-Maria; Frey, Erwin

2013-08-01

The processes leading to change in languages are manifold. In order to reduce ambiguity in the transmission of information, agreement on a set of conventions for recurring problems is favored. In addition to that, speakers tend to use particular linguistic variants associated with the social groups they identify with. The influence of other groups propagating across the speech community as new variant forms sustains the competition between linguistic variants. With the utterance selection model, an evolutionary description of language change, Baxter [Phys. Rev. EPLEEE81539-375510.1103/PhysRevE.73.046118 73, 046118 (2006)] have provided a mathematical formulation of the interactions inside a group of speakers, exploring the mechanisms that lead to or inhibit the fixation of linguistic variants. In this paper, we take the utterance selection model one step further by describing a speech community consisting of multiple interacting groups. Tuning the interaction strength between groups allows us to gain deeper understanding about the way in which linguistic variants propagate and how their distribution depends on the group partitioning. Both for the group size and the number of groups we find scaling behaviors with two asymptotic regimes. If groups are strongly connected, the dynamics is that of the standard utterance selection model, whereas if their coupling is weak, the magnitude of the latter along with the system size governs the way consensus is reached. Furthermore, we find that a high influence of the interlocutor on a speaker's utterances can act as a counterweight to group segregation.

The Influences of Child Intelligibility and Rate on Caregiver Responses to Toddlers With and Without Cleft Palate.

PubMed

Frey, Jennifer R; Kaiser, Ann P; Scherer, Nancy J

2018-02-01

The purpose of this study was to investigate the influences of child speech intelligibility and rate on caregivers' linguistic responses. This study compared the language use of children with cleft palate with or without cleft lip (CP±L) and their caregivers' responses. Descriptive analyses of children's language and caregivers' responses and a multilevel analysis of caregiver responsivity were conducted to determine whether there were differences in children's productive language and caregivers' responses to different types of child utterances. Play-based caregiver-child interactions were video recorded in a clinic setting. Thirty-eight children (19 toddlers with nonsyndromic repaired CP±L and 19 toddlers with typical language development) between 17 and 37 months old and their primary caregivers participated. Child and caregiver measures were obtained from transcribed and coded video recordings and included the rate, total number of words, and number of different words spoken by children and their caregivers, intelligibility of child utterances, and form of caregiver responses. Findings from this study suggest caregivers are highly responsive to toddlers' communication attempts, regardless of the intelligibility of those utterances. However, opportunities to respond were fewer for children with CP±L. Significant differences were observed in children's intelligibility and productive language and in caregivers' use of questions in response to unintelligible utterances of children with and without CP±L. This study provides information about differences in children with CP±L's language use and caregivers' responses to spoken language of toddlers with and without CP±L.

The Carnegie-Chicago Hubble Program. II. The Distance to IC 1613: The Tip of the Red Giant Branch and RR Lyrae Period-luminosity Relations

NASA Astrophysics Data System (ADS)

Hatt, Dylan; Beaton, Rachael L.; Freedman, Wendy L.; Madore, Barry F.; Jang, In-Sung; Hoyt, Taylor J.; Lee, Myung Gyoon; Monson, Andrew J.; Rich, Jeffrey A.; Scowcroft, Victoria; Seibert, Mark

2017-08-01

IC 1613 is an isolated dwarf galaxy within the Local Group. Low foreground and internal extinction, low metallicity, and low crowding make it an invaluable testbed for the calibration of the local distance ladder. We present new, high-fidelity distance estimates to IC 1613 via its Tip of the Red Giant Branch (TRGB) and its RR Lyrae (RRL) variables as part of the Carnegie-Chicago Hubble Program, which seeks an alternate local route to H 0 using Population II stars. We have measured a TRGB magnitude {I}{ACS}{TRGB}=20.35+/- {0.01}{stat}+/- {0.01}{sys} mag using wide-field observations obtained from the IMACS camera on the Magellan-Baade telescope. We have further constructed optical and near-infrared RRL light curves using archival BI- and new H-band observations from the ACS/WFC and WFC3/IR instruments on board the Hubble Space Telescope (HST). In advance of future Gaia data releases, we set provisional values for the TRGB luminosity via the Large Magellanic Cloud and Galactic RRL zero-points via HST parallaxes. We find corresponding true distance moduli {μ }0{TRGB}=24.30+/- {0.03}{stat}+/- {0.05}{sys} {mag} and < {μ }0{RRL}> =24.28+/- {0.04}{stat+{sys}} mag. We compare our results to a body of recent publications on IC 1613 and find no statistically significant difference between the distances derived from Population I and II stars. Based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with programs #10505 and #13691. Additional observations are credited to the Observatories of the Carnegie Institution of Washington for the use of Magellan-Baade IMACS. Presented as part of a dissertation to the Department of Astronomy and Astrophysics, The University of Chicago, in partial fulfillment of the requirements for the Ph.D. degree.

[Prognostic factors related to mortality in newborns with necrotising enterocolitis].

PubMed

Bracho-Blanchet, Eduardo; Torrecilla-Navarrete, María Esther; Zalles-Vidal, Cristian; Ibarra-Ríos, Daniel; Fernández-Portilla, Emilio; Dávila-Pérez, Roberto

2015-01-01

Necrotizing enterocolitis is the most frequent and severe acquired gastrointestinal disease in newborns and still has high mortality. There are few published papers about prognostic factors of death in our country. To know the factors associated with death in patients with necrotizing enterocolitis. Retrospective, descriptive, comparative study with a case-control design was conducted on patients with necrotizing enterocolitis during a 5-year period. Deceased patients had significantly lower platelet counts compared to survivors (P=0.022) and the prognostic factors associated with mortality were anaemia (P=0.006, OR = 15.62), stage III of necrotizing enterocolitis (P<0.001, OR = 47.5), to require surgical treatment (P<0.001, OR = 47.5), to have intestinal necrosis (P=0.001, OR = 48.5) or perforation (P=0.016, OR =24.25), to have medical complications, specifically intravascular disseminated coagulation (P<.001, RR = 98), and multi-organ failure (P<0.001, RR = 2). It was also found that patients with gastrointestinal symptoms and diagnosis of necrotising enterocolitis when they were hospitalized were more likely to have surgical treatment. We must be aware of the factors associated with mortality, as well as those associated with surgical treatment to reduce overall mortality for this condition. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

[Repetitive phenomenona in the spontaneous speech of aphasic patients: perseveration, stereotypy, echolalia, automatism and recurring utterance].

PubMed

Wallesch, C W; Brunner, R J; Seemüller, E

1983-12-01

Repetitive phenomena in spontaneous speech were investigated in 30 patients with chronic infarctions of the left hemisphere which included Broca's and/or Wernicke's area and/or the basal ganglia. Perseverations, stereotypies, and echolalias occurred with all types of brain lesions, automatisms and recurring utterances only with those patients, whose infarctions involved Wernicke's area and basal ganglia. These patients also showed more echolalic responses. The results are discussed in view of the role of the basal ganglia as motor program generators.

New perspectives to the enterotoxigenic E. coli F4 porcine infection model: Susceptibility genotypes in relation to performance, diarrhoea and bacterial shedding.

PubMed

Roubos-van den Hil, Petra J; Litjens, Ralph; Oudshoorn, Anna-Katharina; Resink, Jan Willem; Smits, Coen H M

2017-04-01

Enterotoxigenic E. coli (ETEC), causing post-weaning diarrhoea, is a major problem in weaned piglets. Individual animal responses to ETEC infection show high variability in animal experiments. Two studies were designed to optimize the ETEC F4ac infection model in piglets by combining the genotype susceptibility with performance, diarrhoea incidence and bacterial shedding. The studies were performed with respectively 120 and 80 male piglets that were tested for susceptibility or resistance towards ETEC O149:F4ac by a DNA marker based test. Three different genotypes were observed; resistant (RR), susceptible heterozygote (RS) and susceptible homozygote (SS). Piglets, were orally infected with an inoculum suspension (containing 1.5E8 CFU/ml ETEC F4ac) at day 0, 1 and 2 of the study. Performance, diarrhoea incidence and bacterial shedding were followed for 21days. In the first week after challenge a difference in average daily gain was observed between resistant and susceptible piglets in both studies. For the complete study period no significant differences were observed. Diarrhoea incidence was significantly higher in susceptible pigs compared to the resistant pigs in the first week after challenge. Bacterial shedding was much higher in the susceptible pigs and ETEC excretion lasted longer. ETEC was hardly detected in the faecal material of the resistant pigs. In conclusion, susceptible pigs showed higher diarrhoea incidence and higher numbers of faecal ETEC shedding in the first week after challenge compared to resistant pigs. The DNA marker based test can be used to select pigs that are susceptible for ETEC for inclusion in ETEC infection model, resulting in less animals needed to perform infection studies. Copyright © 2016 Elsevier B.V. All rights reserved.

Cultural Resources Survey of the White Castle Revetment Item, Iberville, Parish, Louisiana.

DTIC Science & Technology

1987-03-06

I~ 14 iles10 1i~A’ Figue Exerp fro May ’ s 887 a2 2 th Stae o Louiiana sho ing he C nno Stoe T ~i7O -i*iion Libray Conress) 38 P 6 5 Lmr-%v o N*.-N ve...4 WJ ... , .1 K.1"c, 4 1, rr ,x -, -.’" 1-€ -MA Y’ . N.- - L / l ..h, S - CA .IS • r •---- s . eo l xaa sh.e,. Xh an nSo e (lp D v so ," ’ Libray of...ACCIPtCAT’S CATALOG NUMOEaR COELMN/PD-86/02 qAC~. I 4.L tITL9 (o &aWeWaJ* s . Type Or mEpOwr & PamIOo COvemeO Cultural Resources Survey of the White

Variable Stars in the M31 Dwarf Spheroidal Companion Cassiopeia

NASA Astrophysics Data System (ADS)

Pritzl, Barton J.; Armandroff, T. E.; Jacoby, G. H.; Da Costa, G. S.

2007-12-01

Dwarf spheroidal galaxies show very diverse star formation histories. For the Galactic dwarf spheroidal galaxies, a correlation exists between Galactocentric distance and the prominence of intermediate-age ( 2 - 10 Gyr) populations. To test whether this correlation exists for the M31 dwarf spheroidal galaxies, we observed the Cassiopeia (And VII) dwarf galaxy, which is one of the most distant M31 dwarf spheroidal galaxies. We will present the results of a variable star search using HST/ACS data, along with a preliminary color-magnitude diagram. From the RR Lyrae stars we can obtain an independent distance and metallicity estimate for the dwarf galaxy. These results will be compared to those found for the other M31 dwarf spheroidal galaxies.This research is supported in part by NASA through grant number GO-11081.11 from the Space Telescope Science Institute.

On the Time Course of Vocal Emotion Recognition

PubMed Central

Pell, Marc D.; Kotz, Sonja A.

2011-01-01

How quickly do listeners recognize emotions from a speaker's voice, and does the time course for recognition vary by emotion type? To address these questions, we adapted the auditory gating paradigm to estimate how much vocal information is needed for listeners to categorize five basic emotions (anger, disgust, fear, sadness, happiness) and neutral utterances produced by male and female speakers of English. Semantically-anomalous pseudo-utterances (e.g., The rivix jolled the silling) conveying each emotion were divided into seven gate intervals according to the number of syllables that listeners heard from sentence onset. Participants (n = 48) judged the emotional meaning of stimuli presented at each gate duration interval, in a successive, blocked presentation format. Analyses looked at how recognition of each emotion evolves as an utterance unfolds and estimated the “identification point” for each emotion. Results showed that anger, sadness, fear, and neutral expressions are recognized more accurately at short gate intervals than happiness, and particularly disgust; however, as speech unfolds, recognition of happiness improves significantly towards the end of the utterance (and fear is recognized more accurately than other emotions). When the gate associated with the emotion identification point of each stimulus was calculated, data indicated that fear (M = 517 ms), sadness (M = 576 ms), and neutral (M = 510 ms) expressions were identified from shorter acoustic events than the other emotions. These data reveal differences in the underlying time course for conscious recognition of basic emotions from vocal expressions, which should be accounted for in studies of emotional speech processing. PMID:22087275

Direct and Indirect Effects of Behavioral Parent Training on Infant Language Production

PubMed Central

Bagner, Daniel M.; Garcia, Dainelys; Hill, Ryan

2016-01-01

Given the strong association between early behavior problems and language impairment, we examined the effect of a brief home-based adaptation of Parent–child Interaction Therapy on infant language production. Sixty infants (55% male; mean age 13.47 ± 1.31 months) were recruited at a large urban primary care clinic and were included if their scores exceeded the 75th percentile on a brief screener of early behavior problems. Families were randomly assigned to receive the home-based parenting intervention or standard pediatric primary care. The observed number of infant total (i.e., token) and different (i.e., type) utterances spoken during an observation of an infant-led play and a parent-report measure of infant externalizing behavior problems were examined at pre- and post-intervention and at 3- and 6-month follow-ups. Infants receiving the intervention demonstrated a significantly higher number of observed different and total utterances at the 6-month follow-up compared to infants in standard care. Furthermore, there was an indirect effect of the intervention on infant language production, such that the intervention led to decreases in infant externalizing behavior problems from pre- to post-intervention, which, in turn, led to increases in infant different utterances at the 3- and 6-month follow-ups and total utterances at the 6-month follow-up. Results provide initial evidence for the effect of this brief and home-based intervention on infant language production, including the indirect effect of the intervention on infant language through improvements in infant behavior, highlighting the importance of targeting behavior problems in early intervention. PMID:26956651

The EPOCH Project. I. Periodic variable stars in the EROS-2 LMC database

NASA Astrophysics Data System (ADS)

Kim, Dae-Won; Protopapas, Pavlos; Bailer-Jones, Coryn A. L.; Byun, Yong-Ik; Chang, Seo-Won; Marquette, Jean-Baptiste; Shin, Min-Su

2014-06-01

The EPOCH (EROS-2 periodic variable star classification using machine learning) project aims to detect periodic variable stars in the EROS-2 light curve database. In this paper, we present the first result of the classification of periodic variable stars in the EROS-2 LMC database. To classify these variables, we first built a training set by compiling known variables in the Large Magellanic Cloud area from the OGLE and MACHO surveys. We crossmatched these variables with the EROS-2 sources and extracted 22 variability features from 28 392 light curves of the corresponding EROS-2 sources. We then used the random forest method to classify the EROS-2 sources in the training set. We designed the model to separate not only δ Scuti stars, RR Lyraes, Cepheids, eclipsing binaries, and long-period variables, the superclasses, but also their subclasses, such as RRab, RRc, RRd, and RRe for RR Lyraes, and similarly for the other variable types. The model trained using only the superclasses shows 99% recall and precision, while the model trained on all subclasses shows 87% recall and precision. We applied the trained model to the entire EROS-2 LMC database, which contains about 29 million sources, and found 117 234 periodic variable candidates. Out of these 117 234 periodic variables, 55 285 have not been discovered by either OGLE or MACHO variability studies. This set comprises 1906 δ Scuti stars, 6607 RR Lyraes, 638 Cepheids, 178 Type II Cepheids, 34 562 eclipsing binaries, and 11 394 long-period variables. catalog of these EROS-2 LMC periodic variable stars is available at http://stardb.yonsei.ac.kr and at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/566/A43

Language Sample Measures and Language Ability in Spanish English Bilingual Kindergarteners

PubMed Central

Bedore, Lisa M.; Peña, Elizabeth D.; Gillam, Ronald B.; Ho, Tsung-Han

2010-01-01

Measures of productivity and sentence organization are useful metrics for quantifying language development and language impairments in monolingual and bilingual children. It is not yet known what measures within and across languages are most informative when evaluating the language skills of bilingual children. The purpose of this study was to evaluate how measures of language productivity and organization in two languages converge with children’s measured language abilities on the Bilingual English Spanish Assessment (BESA), a standardized measure of language ability. 170 kindergarten age children who produced narrative language samples in Spanish and in English based on a wordless picture book were included in the analysis. Samples were analyzed for number of utterances, number of different words, mean length of utterance, and percentage of grammatical utterances. The best predictors of language ability as measured by the BESA scores were English MLU, English grammaticality, and Spanish grammaticality. Results are discussed in relationship to the nature of the measures in each of the languages and in regard to their potential utility for identifying low language ability in bilingual children. PMID:20955835

Learning word order at birth: A NIRS study.

PubMed

Benavides-Varela, Silvia; Gervain, Judit

2017-06-01

In language, the relative order of words in sentences carries important grammatical functions. However, the developmental origins and the neural correlates of the ability to track word order are to date poorly understood. The current study therefore investigates the origins of infants' ability to learn about the sequential order of words, using near-infrared spectroscopy (NIRS) with newborn infants. We have conducted two experiments: one in which a word order change was implemented in 4-word sequences recorded with a list intonation (as if each word was a separate item in a list; list prosody condition, Experiment 1) and one in which the same 4-word sequences were recorded with a well-formed utterance-level prosodic contour (utterance prosody condition, Experiment 2). We found that newborns could detect the violation of the word order in the list prosody condition, but not in the utterance prosody condition. These results suggest that while newborns are already sensitive to word order in linguistic sequences, prosody appears to be a stronger cue than word order for the identification of linguistic units at birth. Copyright © 2017. Published by Elsevier Ltd.

Optical phonetics and visual perception of lexical and phrasal stress in English.

PubMed

Scarborough, Rebecca; Keating, Patricia; Mattys, Sven L; Cho, Taehong; Alwan, Abeer

2009-01-01

In a study of optical cues to the visual perception of stress, three American English talkers spoke words that differed in lexical stress and sentences that differed in phrasal stress, while video and movements of the face were recorded. The production of stressed and unstressed syllables from these utterances was analyzed along many measures of facial movement, which were generally larger and faster in the stressed condition. In a visual perception experiment, 16 perceivers identified the location of stress in forced-choice judgments of video clips of these utterances (without audio). Phrasal stress was better perceived than lexical stress. The relation of the visual intelligibility of the prosody of these utterances to the optical characteristics of their production was analyzed to determine which cues are associated with successful visual perception. While most optical measures were correlated with perception performance, chin measures, especially Chin Opening Displacement, contributed the most to correct perception independently of the other measures. Thus, our results indicate that the information for visual stress perception is mainly associated with mouth opening movements.

Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint.

PubMed

Rosen, Kristin M; Folker, Joanne E; Vogel, Adam P; Corben, Louise A; Murdoch, Bruce E; Delatycki, Martin B

2012-11-01

CNS functions that show change across short periods of time are particularly useful clinical endpoints for Friedreich ataxia. This study determined whether there is measurable acoustical change in the dysarthria associated with Friedreich ataxia across yearly intervals. A total of 29 participants diagnosed with Friedreich ataxia were recorded across 4 years at yearly intervals. A repeated measures ANOVA was used to determine which acoustic measures differed across time, and pairwise t tests were used to assess the consistency of the change across the time intervals. The relationship between the identified measures with perceptual severity was assessed with stepwise regression. Significant longitudinal change was observed with four measures that relate to the utterance duration and spectral changes in utterances. The spectral measures consistently detected change across time intervals of two or more years. The four measures combined moderately predicted perceptual severity. Together, the results implicate longitudinal change in speaking rate and utterance duration. Changes in speech associated with Friedreich ataxia can be measured across intervals of 2 years and therefore show rich potential for monitoring disease progression and therapy outcomes.

Learn Locally, Act Globally: Learning Language from Variation Set Cues

PubMed Central

Onnis, Luca; Waterfall, Heidi R.; Edelman, Shimon

2011-01-01

Variation set structure — partial overlap of successive utterances in child-directed speech — has been shown to correlate with progress in children’s acquisition of syntax. We demonstrate the benefits of variation set structure directly: in miniature artificial languages, arranging a certain proportion of utterances in a training corpus in variation sets facilitated word and phrase constituent learning in adults. Our findings have implications for understanding the mechanisms of L1 acquisition by children, and for the development of more efficient algorithms for automatic language acquisition, as well as better methods for L2 instruction. PMID:19019350

Quantity and Quality of Caregivers' Linguistic Input to 18-Month and 3-Year-Old Children Who Are Hard of Hearing.

PubMed

Ambrose, Sophie E; Walker, Elizabeth A; Unflat-Berry, Lauren M; Oleson, Jacob J; Moeller, Mary Pat

2015-01-01

The primary objective of this study was to examine the quantity and quality of caregiver talk directed to children who are hard of hearing (CHH) compared with children with normal hearing (CNH). For the CHH only, the study explored how caregiver input changed as a function of child age (18 months versus 3 years), which child and family factors contributed to variance in caregiver linguistic input at 18 months and 3 years, and how caregiver talk at 18 months related to child language outcomes at 3 years. Participants were 59 CNH and 156 children with bilateral, mild-to-severe hearing loss. When children were approximately 18 months and/or 3 years of age, caregivers and children participated in a 5-min semistructured, conversational interaction. Interactions were transcribed and coded for two features of caregiver input representing quantity (number of total utterances and number of total words) and four features representing quality (number of different words, mean length of utterance in morphemes, proportion of utterances that were high level, and proportion of utterances that were directing). In addition, at the 18-month visit, parents completed a standardized questionnaire regarding their child's communication development. At the 3-year visit, a clinician administered a standardized language measure. At the 18-month visit, the CHH were exposed to a greater proportion of directing utterances than the CNH. At the 3-year visit, there were significant differences between the CNH and CHH for number of total words and all four of the quality variables, with the CHH being exposed to fewer words and lower quality input. Caregivers generally provided higher quality input to CHH at the 3-year visit compared with the 18-month visit. At the 18-month visit, quantity variables, but not quality variables, were related to several child and family factors. At the 3-year visit, the variable most strongly related to caregiver input was child language. Longitudinal analyses indicated that quality, but not quantity, of caregiver linguistic input at 18 months was related to child language abilities at 3 years, with directing utterances accounting for significant unique variance in child language outcomes. Although caregivers of CHH increased their use of quality features of linguistic input over time, the differences when compared with CNH suggest that some caregivers may need additional support to provide their children with optimal language learning environments. This is particularly important given the relationships that were identified between quality features of caregivers' linguistic input and children's language abilities. Family supports should include a focus on developing a style that is conversational eliciting as opposed to directive.

Speaker-sensitive emotion recognition via ranking: Studies on acted and spontaneous speech☆

PubMed Central

Cao, Houwei; Verma, Ragini; Nenkova, Ani

2014-01-01

We introduce a ranking approach for emotion recognition which naturally incorporates information about the general expressivity of speakers. We demonstrate that our approach leads to substantial gains in accuracy compared to conventional approaches. We train ranking SVMs for individual emotions, treating the data from each speaker as a separate query, and combine the predictions from all rankers to perform multi-class prediction. The ranking method provides two natural benefits. It captures speaker specific information even in speaker-independent training/testing conditions. It also incorporates the intuition that each utterance can express a mix of possible emotion and that considering the degree to which each emotion is expressed can be productively exploited to identify the dominant emotion. We compare the performance of the rankers and their combination to standard SVM classification approaches on two publicly available datasets of acted emotional speech, Berlin and LDC, as well as on spontaneous emotional data from the FAU Aibo dataset. On acted data, ranking approaches exhibit significantly better performance compared to SVM classification both in distinguishing a specific emotion from all others and in multi-class prediction. On the spontaneous data, which contains mostly neutral utterances with a relatively small portion of less intense emotional utterances, ranking-based classifiers again achieve much higher precision in identifying emotional utterances than conventional SVM classifiers. In addition, we discuss the complementarity of conventional SVM and ranking-based classifiers. On all three datasets we find dramatically higher accuracy for the test items on whose prediction the two methods agree compared to the accuracy of individual methods. Furthermore on the spontaneous data the ranking and standard classification are complementary and we obtain marked improvement when we combine the two classifiers by late-stage fusion. PMID:25422534

Who is respectful? Effects of social context and individual empathic ability on ambiguity resolution during utterance comprehension

PubMed Central

Jiang, Xiaoming; Zhou, Xiaolin

2015-01-01

Verbal communication is often ambiguous. By employing the event-related potential (ERP) technique, this study investigated how a comprehender resolves referential ambiguity by using information concerning the social status of communicators. Participants read a conversational scenario which included a minimal conversational context describing a speaker and two other persons of the same or different social status and a directly quoted utterance. A singular, second-person pronoun in the respectful form (nin/nin-de in Chinese) in the utterance could be ambiguous with respect to which of the two persons was the addressee (the “Ambiguous condition”). Alternatively, the pronoun was not ambiguous either because one of the two persons was of higher social status and hence should be the addressee according to social convention (the “Status condition”) or because a word referring to the status of a person was additionally inserted before the pronoun to help indicate the referent of the pronoun (the “Referent condition”). Results showed that the perceived ambiguity decreased over the Ambiguous, Status, and Referent conditions. Electrophysiologically, the pronoun elicited an increased N400 in the Referent than in the Status and the Ambiguous conditions, reflecting an increased integration demand due to the necessity of linking the pronoun to both its antecedent and the status word. Relative to the Referent condition, a late, sustained positivity was elicited for the Status condition starting from 600 ms, while a more delayed, anterior negativity was elicited for the Ambiguous condition. Moreover, the N400 effect was modulated by individuals' sensitivity to the social status information, while the late positivity effect was modulated by individuals' empathic ability. These findings highlight the neurocognitive flexibility of contextual bias in referential processing during utterance comprehension. PMID:26557102

Working memory and sentence comprehension of Hong Kong Chinese children with specific language impairment.

PubMed

Siu, Elaine; Man, David W K

2006-09-01

Children with Specific Language Impairment present with delayed language development, but do not have a history of hearing impairment, mental deficiency, or associated social or behavioral problems. Non-word repetition was suggested as an index to reflect the capacity of phonological working memory. There is a paucity of such studies among Hong Kong Chinese children. This preliminary study aimed to examine the relationship between phonological working memory and Specific Language Impairment, through the processes of non-word repetition and sentence comprehension, of children with Specific Language Impairment and pre-school children with normal language development. Both groups of children were screened by a standardized language test. A list of Cantonese (the commonest dialect used in Hong Kong) multisyllabic nonsense utterances and a set of 18 sentences were developed for this study. t-tests and Pearson correlation were used to study the relationship between non-word repetition, working memory and specific language impairment. Twenty-three pre-school children with Specific Language Impairment (mean age = 68.30 months; SD = 6.90) and another 23 pre-school children (mean age = 67.30 months; SD = 6.16) participated in the study. Significant difference performance was found between the Specific Language Impairment group and normal language group in the multisyllabic nonsense utterances repetition task and the sentence comprehension task. Length effect was noted in Specific Language Impairment group children, which is consistent with the findings of other literature. In addition, correlations were also observed between the number of nonsense utterances repeated and the number of elements comprehended. Cantonese multisyllabic nonsense utterances might be worth further developing as a screening tool for the early detection of children with Specific Language Impairment.

Revisiting speech rate and utterance length manipulations in stuttering speakers.

PubMed

Blomgren, Michael; Goberman, Alexander M

2008-01-01

The goal of this study was to evaluate stuttering frequency across a multidimensional (2x2) hierarchy of speech performance tasks. Specifically, this study examined the interaction between changes in length of utterance and levels of speech rate stability. Forty-four adult male speakers participated in the study (22 stuttering speakers and 22 non-stuttering speakers). Participants were audio and video recorded while producing a spontaneous speech task and four different experimental speaking tasks. The four experimental speaking tasks involved reading a list of 45 words and a list 45 phrases two times each. One reading of each list involved speaking at a steady habitual rate (habitual rate tasks) and another reading involved producing each list at a variable speaking rate (variable rate tasks). For the variable rate tasks, participants were directed to produce words or phrases at randomly ordered slow, habitual, and fast rates. The stuttering speakers exhibited significantly more stuttering on the variable rate tasks than on the habitual rate tasks. In addition, the stuttering speakers exhibited significantly more stuttering on the first word of the phrase length tasks compared to the single word tasks. Overall, the results indicated that varying levels of both utterance length and temporal complexity function to modulate stuttering frequency in adult stuttering speakers. Discussion focuses on issues of speech performance according to stuttering severity and possible clinical implications. The reader will learn about and be able to: (1) describe the mediating effects of length of utterance and speech rate on the frequency of stuttering in stuttering speakers; (2) understand the rationale behind multidimensional skill performance matrices; and (3) describe possible applications of motor skill performance matrices to stuttering therapy.

An fMRI investigation of analogical mapping in metaphor comprehension: the influence of context and individual cognitive capacities on processing demands.

PubMed

Prat, Chantel S; Mason, Robert A; Just, Marcel Adam

2012-03-01

This study used fMRI to investigate the neural correlates of analogical mapping during metaphor comprehension, with a focus on dynamic configuration of neural networks with changing processing demands and individual abilities. Participants with varying vocabulary sizes and working memory capacities read 3-sentence passages ending in nominal critical utterances of the form "X is a Y." Processing demands were manipulated by varying preceding contexts. Three figurative conditions manipulated difficulty by varying the extent to which preceding contexts mentioned relevant semantic features for relating the vehicle and topic of the critical utterance to one another. In the easy condition, supporting information was mentioned. In the neutral condition, no relevant information was mentioned. In the most difficult condition, opposite features were mentioned, resulting in an ironic interpretation of the critical utterance. A fourth, literal condition included context that supported a literal interpretation of the critical utterance. Activation in lateral and medial frontal regions increased with increasing contextual difficulty. Lower vocabulary readers also had greater activation across conditions in the right inferior frontal gyrus. In addition, volumetric analyses showed increased right temporo-parietal junction and superior medial frontal activation for all figurative conditions over the literal condition. The results from this experiment imply that the cortical regions are dynamically recruited in language comprehension as a function of the processing demands of a task. Individual differences in cognitive capacities were also associated with differences in recruitment and modulation of working memory and executive function regions, highlighting the overlapping computations in metaphor comprehension and general thinking and reasoning. 2012 APA, all rights reserved

Speaker-sensitive emotion recognition via ranking: Studies on acted and spontaneous speech☆

PubMed

Cao, Houwei; Verma, Ragini; Nenkova, Ani

2015-01-01

We introduce a ranking approach for emotion recognition which naturally incorporates information about the general expressivity of speakers. We demonstrate that our approach leads to substantial gains in accuracy compared to conventional approaches. We train ranking SVMs for individual emotions, treating the data from each speaker as a separate query, and combine the predictions from all rankers to perform multi-class prediction. The ranking method provides two natural benefits. It captures speaker specific information even in speaker-independent training/testing conditions. It also incorporates the intuition that each utterance can express a mix of possible emotion and that considering the degree to which each emotion is expressed can be productively exploited to identify the dominant emotion. We compare the performance of the rankers and their combination to standard SVM classification approaches on two publicly available datasets of acted emotional speech, Berlin and LDC, as well as on spontaneous emotional data from the FAU Aibo dataset. On acted data, ranking approaches exhibit significantly better performance compared to SVM classification both in distinguishing a specific emotion from all others and in multi-class prediction. On the spontaneous data, which contains mostly neutral utterances with a relatively small portion of less intense emotional utterances, ranking-based classifiers again achieve much higher precision in identifying emotional utterances than conventional SVM classifiers. In addition, we discuss the complementarity of conventional SVM and ranking-based classifiers. On all three datasets we find dramatically higher accuracy for the test items on whose prediction the two methods agree compared to the accuracy of individual methods. Furthermore on the spontaneous data the ranking and standard classification are complementary and we obtain marked improvement when we combine the two classifiers by late-stage fusion.

A study of the effectiveness of machine learning methods for classification of clinical interview fragments into a large number of categories.

PubMed

Hasan, Mehedi; Kotov, Alexander; Carcone, April; Dong, Ming; Naar, Sylvie; Hartlieb, Kathryn Brogan

2016-08-01

This study examines the effectiveness of state-of-the-art supervised machine learning methods in conjunction with different feature types for the task of automatic annotation of fragments of clinical text based on codebooks with a large number of categories. We used a collection of motivational interview transcripts consisting of 11,353 utterances, which were manually annotated by two human coders as the gold standard, and experimented with state-of-art classifiers, including Naïve Bayes, J48 Decision Tree, Support Vector Machine (SVM), Random Forest (RF), AdaBoost, DiscLDA, Conditional Random Fields (CRF) and Convolutional Neural Network (CNN) in conjunction with lexical, contextual (label of the previous utterance) and semantic (distribution of words in the utterance across the Linguistic Inquiry and Word Count dictionaries) features. We found out that, when the number of classes is large, the performance of CNN and CRF is inferior to SVM. When only lexical features were used, interview transcripts were automatically annotated by SVM with the highest classification accuracy among all classifiers of 70.8%, 61% and 53.7% based on the codebooks consisting of 17, 20 and 41 codes, respectively. Using contextual and semantic features, as well as their combination, in addition to lexical ones, improved the accuracy of SVM for annotation of utterances in motivational interview transcripts with a codebook consisting of 17 classes to 71.5%, 74.2%, and 75.1%, respectively. Our results demonstrate the potential of using machine learning methods in conjunction with lexical, semantic and contextual features for automatic annotation of clinical interview transcripts with near-human accuracy. Copyright © 2016 Elsevier Inc. All rights reserved.

Direct and Indirect Effects of Behavioral Parent Training on Infant Language Production.

PubMed

Bagner, Daniel M; Garcia, Dainelys; Hill, Ryan

2016-03-01

Given the strong association between early behavior problems and language impairment, we examined the effect of a brief home-based adaptation of Parent-child Interaction Therapy on infant language production. Sixty infants (55% male; mean age 13.47±1.31 months) were recruited at a large urban primary care clinic and were included if their scores exceeded the 75th percentile on a brief screener of early behavior problems. Families were randomly assigned to receive the home-based parenting intervention or standard pediatric primary care. The observed number of infant total (i.e., token) and different (i.e., type) utterances spoken during an observation of an infant-led play and a parent-report measure of infant externalizing behavior problems were examined at pre- and post-intervention and at 3- and 6-month follow-ups. Infants receiving the intervention demonstrated a significantly higher number of observed different and total utterances at the 6-month follow-up compared to infants in standard care. Furthermore, there was an indirect effect of the intervention on infant language production, such that the intervention led to decreases in infant externalizing behavior problems from pre- to post-intervention, which, in turn, led to increases in infant different utterances at the 3- and 6-month follow-ups and total utterances at the 6-month follow-up. Results provide initial evidence for the effect of this brief and home-based intervention on infant language production, including the indirect effect of the intervention on infant language through improvements in infant behavior, highlighting the importance of targeting behavior problems in early intervention. Copyright © 2015. Published by Elsevier Ltd.

Talking about friends, drugs, and change: meanings of friendship in substance abusers' change talk.

PubMed

Sarpavaara, Harri

2014-05-01

This article explores the meanings of substance-abusing clients attach to friendships during motivational treatment sessions in Probation Service. Sessions (98) were videotaped in 12 probation service offices in Finland in 2007 to 2009. By using semiotic framework, this qualitative study examines client's change talk utterance about friendships as a symbolic sign. The findings indicate that the friendships play an important role in the substance-abusing clients' motivation to change and in their treatment outcome. The study suggests that the personal meanings of clients' utterances in motivational treatment sessions could be seen as potential predictors of their future behavior.

Echolalia and comprehension in autistic children.

PubMed

Roberts, J M

1989-06-01

The research reported in this paper investigates the phenomenon of echolalia in the speech of autistic children by examining the relationship between the frequency of echolalia and receptive language ability. The receptive language skills of 10 autistic children were assessed, and spontaneous speech samples were recorded. Analysis of these data showed that those children with poor receptive language skills produced significantly more echolalic utterances than those children whose receptive skills were more age-appropriate. Children who produced fewer echolalic utterances, and had more advanced receptive language ability, evidenced a higher proportion of mitigated echolalia. The most common type of mitigation was echo plus affirmation or denial.

Knowledge and implicature: modeling language understanding as social cognition.

PubMed

Goodman, Noah D; Stuhlmüller, Andreas

2013-01-01

Is language understanding a special case of social cognition? To help evaluate this view, we can formalize it as the rational speech-act theory: Listeners assume that speakers choose their utterances approximately optimally, and listeners interpret an utterance by using Bayesian inference to "invert" this model of the speaker. We apply this framework to model scalar implicature ("some" implies "not all," and "N" implies "not more than N"). This model predicts an interaction between the speaker's knowledge state and the listener's interpretation. We test these predictions in two experiments and find good fit between model predictions and human judgments. Copyright © 2013 Cognitive Science Society, Inc.

The Association Between Parental Mean Length of Utterance and Language Outcomes in Children With Disabilities: A Correlational Meta-Analysis.

PubMed

Sandbank, Micheal; Yoder, Paul

2016-05-01

The purpose of this correlational meta-analysis was to examine the association between parental utterance length and language outcomes in children with disabilities and whether this association varies according to other child characteristics, such as age and disability type. This association can serve as a starting point for language intervention practices for children with disabilities. We conducted a systematic search of 42 electronic databases to identify relevant studies. Twelve studies reporting on a total of 13 populations (including 257 participants) were identified. A random-effects model was used to estimate a combined effect size across all studies as well as separate effect sizes across studies in each disability category. The combined effect size across all studies suggests a weak positive association between parental input length and child language outcomes. However, subgroup analyses within disability categories suggest that this association may differ for children with autism. Results of 4 studies including 47 children with autism show that parental input length is strongly associated with positive language outcomes in this population. Present evidence suggests that clinicians should reconsider intervention practices that prescribe shorter, grammatically incomplete utterances, particularly when working with children with autism.

Language discrimination without language: Experiments on tamarin monkeys

NASA Astrophysics Data System (ADS)

Tincoff, Ruth; Hauser, Marc; Spaepen, Geertrui; Tsao, Fritz; Mehler, Jacques

2002-05-01

Human newborns can discriminate spoken languages differing on prosodic characteristics such as the timing of rhythmic units [T. Nazzi et al., JEP:HPP 24, 756-766 (1998)]. Cotton-top tamarins have also demonstrated a similar ability to discriminate a morae- (Japanese) vs a stress-timed (Dutch) language [F. Ramus et al., Science 288, 349-351 (2000)]. The finding that tamarins succeed in this task when either natural or synthesized utterances are played in a forward direction, but fail on backward utterances which disrupt the rhythmic cues, suggests that sensitivity to language rhythm may rely on general processes of the primate auditory system. However, the rhythm hypothesis also predicts that tamarins would fail to discriminate languages from the same rhythm class, such as English and Dutch. To assess the robustness of this ability, tamarins were tested on a different-rhythm-class distinction, Polish vs Japanese, and a new same-rhythm-class distinction, English vs Dutch. The stimuli were natural forward utterances produced by multiple speakers. As predicted by the rhythm hypothesis, tamarins discriminated between Polish and Japanese, but not English and Dutch. These findings strengthen the claim that discriminating the rhythmic cues of language does not require mechanisms specialized for human speech. [Work supported by NSF.

Syllable-related breathing in infants in the second year of life.

PubMed

Parham, Douglas F; Buder, Eugene H; Oller, D Kimbrough; Boliek, Carol A

2011-08-01

This study explored whether breathing behaviors of infants within the 2nd year of life differ between tidal breathing and breathing supporting single unarticulated syllables and canonical/articulated syllables. Vocalizations and breathing kinematics of 9 infants between 53 and 90 weeks of age were recorded. A strict selection protocol was used to identify analyzable breath cycles. Syllables were categorized on the basis of consensus coding. Inspiratory and expiratory durations, excursions, and slopes were calculated for the 3 breath cycle types and were normalized using mean tidal breath measures. Tidal breathing cycles were significantly different from syllable-related cycles on all breathing measures. There were no significant differences between unarticulated syllable cycles and canonical syllable cycles, even after controlling for utterance duration and sound pressure level. Infants in the 2nd year of life exhibit clear differences between tidal breathing and speech-related breathing, but categorically distinct breath support for syllable types with varying articulatory demands was not evident in the present findings. Speech development introduces increasingly complex utterances, so older infants may produce detectable articulation-related adaptations of breathing kinematics. For younger infants, breath support may vary systematically among utterance types, due more to phonatory variations than to articulatory demands.

Syllable-Related Breathing in Infants in the Second Year of Life

PubMed Central

Parham, Douglas F.; Buder, Eugene H.; Oller, D. Kimbrough; Boliek, Carol A.

2010-01-01

Purpose This study explored whether breathing behaviors of infants within the second year of life differ between tidal breathing and breathing supporting single unarticulated syllables and canonical/articulated syllables. Method Vocalizations and breathing kinematics of nine infants between 53 and 90 weeks of age were recorded. A strict selection protocol was used to identify analyzable breath cycles. Syllables were categorized based on consensus coding. Inspiratory and expiratory durations, excursions, and slopes were calculated for the three breath cycle types and normalized using mean tidal breath measures. Results Tidal breathing cycles were significantly different from syllable-related cycles on all breathing measures. There were no significant differences between unarticulated syllable cycles and canonical syllable cycles, even after controlling for utterance duration and sound pressure level. Conclusions Infants in the second year of life exhibit clear differences between tidal breathing and speech-related breathing, but categorically distinct breath support for syllable types with varying articulatory demands was not evident in the current findings. Speech development introduces increasingly complex utterances, so older infants may produce detectable articulation-related adaptations of breathing kinematics. For younger infants, breath support may vary systematically among utterance types, due more to phonatory variations than to articulatory demands. PMID:21173390

Referential communication abilities in children with 22q11.2 deletion syndrome.

PubMed

Van Den Heuvel, Ellen; ReuterskiöLd, Christina; Solot, Cynthia; Manders, Eric; Swillen, Ann; Zink, Inge

2017-10-01

This study describes the performance on a perspective- and role-taking task in 27 children, ages 6-13 years, with 22q11.2 deletion syndrome (22q11.2DS). A cross-cultural design comparing Dutch- and English-speaking children with 22q11.2DS explored the possibility of cultural differences. Chronologically age-matched and younger typically developing (TD) children matched for receptive vocabulary served as control groups to identify challenges in referential communication. The utterances of children with 22q11.2DS were characterised as short and simple in lexical and grammatical terms. However, from a language use perspective, their utterances were verbose, ambiguous and irrelevant given the pictured scenes. They tended to elaborate on visual details and conveyed off-topic, extraneous information when participating in a barrier-game procedure. Both types of aberrant utterances forced a listener to consistently infer the intended message. Moreover, children with 22q11.2DS demonstrated difficulty selecting correct speech acts in accordance with contextual cues during a role-taking task. Both English- and Dutch-speaking children with 22q11.2DS showed impoverished information transfer and an increased number of elaborations, suggesting a cross-cultural syndrome-specific feature.

Recurrence Quantification Analysis of Sentence-Level Speech Kinematics.

PubMed

Jackson, Eric S; Tiede, Mark; Riley, Michael A; Whalen, D H

2016-12-01

Current approaches to assessing sentence-level speech variability rely on measures that quantify variability across utterances and use normalization procedures that alter raw trajectory data. The current work tests the feasibility of a less restrictive nonlinear approach-recurrence quantification analysis (RQA)-via a procedural example and subsequent analysis of kinematic data. To test the feasibility of RQA, lip aperture (i.e., the Euclidean distance between lip-tracking sensors) was recorded for 21 typically developing adult speakers during production of a simple utterance. The utterance was produced in isolation and in carrier structures differing just in length or in length and complexity. Four RQA indices were calculated: percent recurrence (%REC), percent determinism (%DET), stability (MAXLINE), and stationarity (TREND). Percent determinism (%DET) decreased only for the most linguistically complex sentence; MAXLINE decreased as a function of linguistic complexity but increased for the longer-only sentence; TREND decreased as a function of both length and linguistic complexity. This research note demonstrates the feasibility of using RQA as a tool to compare speech variability across speakers and groups. RQA offers promise as a technique to assess effects of potential stressors (e.g., linguistic or cognitive factors) on the speech production system.

The Timing of Utterance Planning in Task-Oriented Dialogue: Evidence from a Novel List-Completion Paradigm

PubMed Central

Barthel, Mathias; Sauppe, Sebastian; Levinson, Stephen C.; Meyer, Antje S.

2016-01-01

In conversation, interlocutors rarely leave long gaps between turns, suggesting that next speakers begin to plan their turns while listening to the previous speaker. The present experiment used analyses of speech onset latencies and eye-movements in a task-oriented dialogue paradigm to investigate when speakers start planning their responses. German speakers heard a confederate describe sets of objects in utterances that either ended in a noun [e.g., Ich habe eine Tür und ein Fahrrad (“I have a door and a bicycle”)] or a verb form [e.g., Ich habe eine Tür und ein Fahrrad besorgt (“I have gotten a door and a bicycle”)], while the presence or absence of the final verb either was or was not predictable from the preceding sentence structure. In response, participants had to name any unnamed objects they could see in their own displays with utterances such as Ich habe ein Ei (“I have an egg”). The results show that speakers begin to plan their turns as soon as sufficient information is available to do so, irrespective of further incoming words. PMID:27990127

Recurrence Quantification Analysis of Sentence-Level Speech Kinematics

PubMed Central

Tiede, Mark; Riley, Michael A.; Whalen, D. H.

2016-01-01

Purpose Current approaches to assessing sentence-level speech variability rely on measures that quantify variability across utterances and use normalization procedures that alter raw trajectory data. The current work tests the feasibility of a less restrictive nonlinear approach—recurrence quantification analysis (RQA)—via a procedural example and subsequent analysis of kinematic data. Method To test the feasibility of RQA, lip aperture (i.e., the Euclidean distance between lip-tracking sensors) was recorded for 21 typically developing adult speakers during production of a simple utterance. The utterance was produced in isolation and in carrier structures differing just in length or in length and complexity. Four RQA indices were calculated: percent recurrence (%REC), percent determinism (%DET), stability (MAXLINE), and stationarity (TREND). Results Percent determinism (%DET) decreased only for the most linguistically complex sentence; MAXLINE decreased as a function of linguistic complexity but increased for the longer-only sentence; TREND decreased as a function of both length and linguistic complexity. Conclusions This research note demonstrates the feasibility of using RQA as a tool to compare speech variability across speakers and groups. RQA offers promise as a technique to assess effects of potential stressors (e.g., linguistic or cognitive factors) on the speech production system. PMID:27824987

Accent, intelligibility, and comprehensibility in the perception of foreign-accented Lombard speech

NASA Astrophysics Data System (ADS)

Li, Chi-Nin

2003-10-01

Speech produced in noise (Lombard speech) has been reported to be more intelligible than speech produced in quiet (normal speech). This study examined the perception of non-native Lombard speech in terms of intelligibility, comprehensibility, and degree of foreign accent. Twelve Cantonese speakers and a comparison group of English speakers read simple true and false English statements in quiet and in 70 dB of masking noise. Lombard and normal utterances were mixed with noise at a constant signal-to-noise ratio, and presented along with noise-free stimuli to eight new English listeners who provided transcription scores, comprehensibility ratings, and accent ratings. Analyses showed that, as expected, utterances presented in noise were less well perceived than were noise-free sentences, and that the Cantonese speakers' productions were more accented, but less intelligible and less comprehensible than those of the English speakers. For both groups of speakers, the Lombard sentences were correctly transcribed more often than their normal utterances in noisy conditions. However, the Cantonese-accented Lombard sentences were not rated as easier to understand than was the normal speech in all conditions. The assigned accent ratings were similar throughout all listening conditions. Implications of these findings will be discussed.

A Detailed Study of the Variable Stars in Five Galactic Globular Clusters: IC4499, NGC4833, NGC6171 (M107), NGC6402 (M14), and NGC6584

NASA Astrophysics Data System (ADS)

Murphy, Brian W.; Darragh, Andrew; Hettinger, Paul; Hibshman, Adam; Johnson, Elliott W.; Liu, Z. J.; Pajkos, Michael A.; Stephenson, Hunter R.; Vondersaar, John R.; Conroy, Kyle E.; McCombs, Thayne A.; Reinhardt, Erik D.; Toddy, Joseph

2015-08-01

We present the results of an extensive study intended to search for and properly classify the variable stars in five galactic globular clusters. Each of the five clusters was observed hundreds to thousands of times over a time span ranging from 2 to 4 years using the SARA 0.6m located at Cerro Tololo Interamerican Observatory. The images were analyzed using the image subtract method of Alard (2000) to identify and produce light curves of all variables found in each cluster. In total we identified 373 variables with 140 of these being newly discovered increasing the number of known variables stars in these clusters by 60%. Of the total we have identified 312 RR Lyrae variables (187 RR0, 18 RR01, 99 RR1, 8 RR2), 9 SX Phe stars, 6 Cepheid variables, 11 eclipsing variables, and 35 long period variables. For IC4499 we identified 64 RR0, 18 RR01, 14 RR1, 4 RR2, 1 SX Phe, 1 eclipsing binary, and 2 long period variables. For NGC4833 we identified 10 RR0, 7 RR1, 2 RR2, 6 SX Phe, 5 eclipsing binaries, and 9 long period variables. For NGC6171 (M107) we identified 13 RR0, 7 RR1, and 1 SX Phe. For NGC6402 (M14) we identified 52 RR0, 56 RR1, 1 RR2, 1 SX Phe, 6 Cepheids, 1 eclipsing binary, and 15 long period variables. For NGC6584 we identified 48 RR0, 15 RR1, 1 RR2, 5 eclipsing binaries, and 9 long period variables. Using the RR Lyrae variables we found the mean V magnitude of the horizontal branch to be VHB = ⟨V ⟩RR = 17.63, 15.51, 15.72, 17.13, and 16.37 magnitudes for IC4499, NGC4833, NGC6171 (M107), NGC6402 (M14), and NGC6584, respectively. From our extensive data set we were able to obtain sufficient temporal and complete phase coverage of the RR Lyrae variables. This has allowed us not only to properly classify each of the RR Lyrae variables but also to use Fourier decomposition of the light curves to further analyze the properties of the variable stars and hence physical properties of each clusters. In this poster we will give the temperature, radius, stellar mass, metallicity, and helium abundance of the set of RR Lyrae variable stars found in each of the five globular clusters.

A Detailed Survey of Pulsating Variables in Five Globular Clusters (Abstract)

NASA Astrophysics Data System (ADS)

Murphy, B. W.

2016-12-01

(Abstract only) Globular clusters are ideal laboratories for conducting a stellar census. Of particular interest are pulsating variables, which provide astronomers with a tool to probe the properties of the stars and the cluster. We observed each of five globular clusters hundreds to thousands of times over a time span ranging from 2 to 4 years in B, V, and I filters using the SARA 0.6-meter telescope located at Cerro Tololo Interamerican Observatory and the 0.9-meter telescope located at Kitt Peak, Arizona. The images were analyzed using difference image analysis to identify and produce light curves of all variables found in each cluster. In total we identified 377 variables with 140 of these being newly discovered increasing the number of known variables stars in these clusters by 60%. Of the total we have identified 319 RR Lyrae variables (193 RR0, 18 RR01, 101 RR1, 7 RR2), 9 SX Phe stars, 5 Cepheid variables, 11 eclipsing variables, and 33 long period variables. For IC4499 we identified 64 RR0, 18 RR01, 14 RR1, 4 RR2, 1 SX Phe, 1 eclipsing binary, and 2 long period variables. For NGC4833 we identified 10 RR0, 7 RR1, 3 RR2, 6 SX Phe, 5 eclipsing binaries, and 9 long period variables. For NGC6171 (M107) we identified 14 RR0, 7 RR1, and 1 SX Phe. For NGC6402 (M14) we identified 55 RR0, 57 RR1, 1 RR2, 1 SX Phe, 6 Cepheids, 1 eclipsing binary, and 15 long period variables. For NGC6584 we identified 50 RR0, 16 RR1, 4 eclipsing binaries, and 7 long period variables. From our extensive data set we were able to obtain sufficient temporal and complete phase coverage of the RR Lyrae variables. This has allowed us not only to properly classify each of the RR Lyrae variables but also to use Fourier decomposition of the B, V, and I light curves to further analyze the properties of the variable stars and hence the physical properties of each globular cluster.

Healthcare use for communicable diseases among migrant workers in comparison with Thai workers.

PubMed

Rakprasit, Jutarat; Nakamura, Keiko; Seino, Kaoruko; Morita, Ayako

2017-02-07

This study examines healthcare use in 2011 for communicable diseases among migrant workers compared with Thai workers in Thailand. The relative risks (RRs) of 14 communicable diseases (803,817 cases between ages 18 and 59) were calculated using the National Epidemiological Surveillance System, a nationwide hospital database. Regarding the migrant workers, 71.0% were Burmese and 17.3% were Cambodians. Significantly high comparative RRs for migrant workers were found for tuberculosis (TB) (male, RR=1.41; female, RR=2.33), sexually transmitted infections (STIs) (male, RR=2.39; female, RR=1.64), and malaria (male, RR=8.31; female, RR=11.45). Significantly low comparative RRs for migrant workers were found for diarrhea (male, RR=0.39; female, RR=0.28), food poisoning (male, RR=0.33; female, RR=0.24), dengue (male, RR=0.82; female, RR=0.68), and others. By occupation, RRs for TB and STIs were high among laborers but low among farmers. RRs for malaria among farmers (male, RR=18.26, female, RR=25.49) was higher than among laborers (male, RR=10.04; female, RR=13.93). The study indicated a higher risk of TB, STIs, and malaria for migrant workers, but a lower risk of diarrhea, food poisoning, dengue, and others. Although general health support program for migrants have promoted maternal and child health, prevention of communicable diseases should be further strengthened to meet the needs of migrants.

Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin.

PubMed

Lee, Taek Hwan; Kang, Ji Hee; Seo, Jae Ok; Baek, So-Hyeon; Moh, Sang Hyun; Chae, Jae Kyoung; Park, Yong Un; Ko, Young Tag; Kim, Sun Yeou

2016-01-01

We already reported that genetically engineered resveratrol-enriched rice (RR) showed to down-regulate skin melanogenesis. To be developed to increase the bioactivity of RR using calli from plants, RR was adopted for mass production using plant tissue culture technologies. In addition, high-pressure homogenization (HPH) was used to increase the biocompatibility and penetration of the calli from RR into the skin. We aimed to develop anti-melanogenic agents incorporating calli of RR (cRR) and nanoparticles by high-pressure homogenization, examining the synergistic effects on the inhibition of UVB-induced hyperpigmentation. Depigmentation was observed following topical application of micro-cRR, nano-calli of normal rice (cNR), and nano-cRR to ultraviolet B (UVB)-stimulated hyperpigmented guinea pig dorsal skin. Colorimetric analysis, tyrosinase immunostaining, and Fontana-Masson staining for UVB-promoted melanin were performed. Nano-cRR inhibited changes in the melanin color index caused by UVB-promoted hyperpigmentation, and demonstrated stronger anti-melanogenic potential than micro-cRR. In epidermal skin, nano-cRR repressed UVB-promoted melanin granules, thereby suppressing hyperpigmentation. The UVB-enhanced, highly expressed tyrosinase in the basal layer of the epidermis was inhibited by nano-cRR more prominently than by micro-cRR and nano-cNR. The anti-melanogenic potency of nano-cRR also depended on pH and particle size. Nano-cRR shows promising potential to regulate skin pigmentation following UVB exposure.

Phonological Planning during Sentence Production: Beyond the Verb.

PubMed

Schnur, Tatiana T

2011-01-01

The current study addresses the extent of phonological planning during spontaneous sentence production. Previous work shows that at articulation, phonological encoding occurs for entire phrases, but encoding beyond the initial phrase may be due to the syntactic relevance of the verb in planning the utterance. I conducted three experiments to investigate whether phonological planning crosses multiple grammatical phrase boundaries (as defined by the number of lexical heads of phrase) within a single phonological phrase. Using the picture-word interference paradigm, I found in two separate experiments a significant phonological facilitation effect to both the verb and noun of sentences like "He opens the gate." I also altered the frequency of the direct object and found longer utterance initiation times for sentences ending with a low-frequency vs. high-frequency object offering further support that the direct object was phonologically encoded at the time of utterance initiation. That phonological information for post-verbal elements was activated suggests that the grammatical importance of the verb does not restrict the extent of phonological planning. These results suggest that the phonological phrase is unit of planning, where all elements within a phonological phrase are encoded before articulation. Thus, consistent with other action sequencing behavior, there is significant phonological planning ahead in sentence production.

Mobbing calls signal predator category in a kin group-living bird species

PubMed Central

Griesser, Michael

2009-01-01

Many prey species gather together to approach and harass their predators despite the associated risks. While mobbing, prey usually utter calls and previous experiments have demonstrated that mobbing calls can convey information about risk to conspecifics. However, the risk posed by predators also differs between predator categories. The ability to communicate predator category would be adaptive because it would allow other mobbers to adjust their risk taking. I tested this idea in Siberian jays Perisoreus infaustus, a group-living bird species, by exposing jay groups to mounts of three hawk and three owl species of varying risks. Groups immediately approached to mob the mount and uttered up to 14 different call types. Jays gave more calls when mobbing a more dangerous predator and when in the presence of kin. Five call types were predator-category-specific and jays uttered two hawk-specific and three owl-specific call types. Thus, this is one of the first studies to demonstrate that mobbing calls can simultaneously encode information about both predator category and the risk posed by a predator. Since antipredator calls of Siberian jays are known to specifically aim at reducing the risk to relatives, kin-based sociality could be an important factor in facilitating the evolution of predator-category-specific mobbing calls. PMID:19474047

Mobbing calls signal predator category in a kin group-living bird species.

PubMed

Griesser, Michael

2009-08-22

Many prey species gather together to approach and harass their predators despite the associated risks. While mobbing, prey usually utter calls and previous experiments have demonstrated that mobbing calls can convey information about risk to conspecifics. However, the risk posed by predators also differs between predator categories. The ability to communicate predator category would be adaptive because it would allow other mobbers to adjust their risk taking. I tested this idea in Siberian jays Perisoreus infaustus, a group-living bird species, by exposing jay groups to mounts of three hawk and three owl species of varying risks. Groups immediately approached to mob the mount and uttered up to 14 different call types. Jays gave more calls when mobbing a more dangerous predator and when in the presence of kin. Five call types were predator-category-specific and jays uttered two hawk-specific and three owl-specific call types. Thus, this is one of the first studies to demonstrate that mobbing calls can simultaneously encode information about both predator category and the risk posed by a predator. Since antipredator calls of Siberian jays are known to specifically aim at reducing the risk to relatives, kin-based sociality could be an important factor in facilitating the evolution of predator-category-specific mobbing calls.

Testing theories of irony processing using eye-tracking and ERPs.

PubMed

Filik, Ruth; Leuthold, Hartmut; Wallington, Katie; Page, Jemma

2014-05-01

Not much is known about how people comprehend ironic utterances, and to date, most studies have simply compared processing of ironic versus non-ironic statements. A key aspect of the graded salience hypothesis, distinguishing it from other accounts (such as the standard pragmatic view and direct access view), is that it predicts differences between processing of familiar and unfamiliar ironies. Specifically, if an ironic utterance is familiar, then the ironic interpretation should be available without the need for extra inferential processes, whereas for unfamiliar ironies, the literal interpretation would be computed first, and a mismatch with context would lead to a re-interpretation of the statement as being ironic. We recorded participants' eye movements while they were reading (Experiment 1), and electrical brain activity while they were listening to (Experiment 2), familiar and unfamiliar ironies compared to non-ironic controls. Results show disruption to eye movements and an N400-like effect for unfamiliar ironies only, supporting the predictions of the graded salience hypothesis. In addition, in Experiment 2, a late positivity was found for both familiar and unfamiliar ironic materials, compared to non-ironic controls. We interpret this positivity as reflecting ongoing conflict between the literal and ironic interpretations of the utterance. PsycINFO Database Record (c) 2014 APA, all rights reserved.

How do you say 'hello'? Personality impressions from brief novel voices.

PubMed

McAleer, Phil; Todorov, Alexander; Belin, Pascal

2014-01-01

On hearing a novel voice, listeners readily form personality impressions of that speaker. Accurate or not, these impressions are known to affect subsequent interactions; yet the underlying psychological and acoustical bases remain poorly understood. Furthermore, hitherto studies have focussed on extended speech as opposed to analysing the instantaneous impressions we obtain from first experience. In this paper, through a mass online rating experiment, 320 participants rated 64 sub-second vocal utterances of the word 'hello' on one of 10 personality traits. We show that: (1) personality judgements of brief utterances from unfamiliar speakers are consistent across listeners; (2) a two-dimensional 'social voice space' with axes mapping Valence (Trust, Likeability) and Dominance, each driven by differing combinations of vocal acoustics, adequately summarises ratings in both male and female voices; and (3) a positive combination of Valence and Dominance results in increased perceived male vocal Attractiveness, whereas perceived female vocal Attractiveness is largely controlled by increasing Valence. Results are discussed in relation to the rapid evaluation of personality and, in turn, the intent of others, as being driven by survival mechanisms via approach or avoidance behaviours. These findings provide empirical bases for predicting personality impressions from acoustical analyses of short utterances and for generating desired personality impressions in artificial voices.

Effect of Parkinson's disease on the production of structured and unstructured speaking tasks: Respiratory physiologic and linguistic considerations

PubMed Central

Huber, Jessica E.; Darling, Meghan

2012-01-01

Purpose The purpose of the present study was to examine the effects of cognitive-linguistic deficits and respiratory physiologic changes on respiratory support for speech in PD, using two speech tasks, reading and extemporaneous speech. Methods Five women with PD, 9 men with PD, and 14 age- and sex-matched control participants read a passage and spoke extemporaneously on a topic of their choice at comfortable loudness. Sound pressure level, syllables per breath group, speech rate, and lung volume parameters were measured. Number of formulation errors, disfluencies, and filled pauses were counted. Results Individuals with PD produced shorter utterances as compared to control participants. The relationships between utterance length and lung volume initiation and inspiratory duration were weaker in individuals with PD than for control participants, particularly for the extemporaneous speech task. These results suggest less consistent planning for utterance length by individuals with PD in extemporaneous speech. Individuals with PD produced more formulation errors in both tasks and significantly fewer filled pauses in extemporaneous speech. Conclusions Both respiratory physiologic and cognitive-linguistic issues affected speech production by individuals with PD. Overall, individuals with PD had difficulty planning or coordinating language formulation and respiratory support, in particular during extemporaneous speech. PMID:20844256

Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children.

PubMed

Suskind, Dana L; Graf, Eileen; Leffel, Kristin R; Hernandez, Marc W; Suskind, Elizabeth; Webber, Robert; Tannenbaum, Sally; Nevins, Mary Ellen

2016-02-01

To investigate the impact of a spoken language intervention curriculum aiming to improve the language environments caregivers of low socioeconomic status (SES) provide for their D/HH children with CI & HA to support children's spoken language development. Quasiexperimental. Tertiary. Thirty-two caregiver-child dyads of low-SES (as defined by caregiver education ≤ MA/MS and the income proxies = Medicaid or WIC/LINK) and children aged < 4.5 years, hearing loss of ≥ 30 dB, between 500 and 4000 Hz, using at least one amplification device with adequate amplification (hearing aid, cochlear implant, osseo-integrated device). Behavioral. Caregiver-directed educational intervention curriculum designed to improve D/HH children's early language environments. Changes in caregiver knowledge of child language development (questionnaire scores) and language behavior (word types, word tokens, utterances, mean length of utterance [MLU], LENA Adult Word Count (AWC), Conversational Turn Count (CTC)). Significant increases in caregiver questionnaire scores as well as utterances, word types, word tokens, and MLU in the treatment but not the control group. No significant changes in LENA outcomes. Results partially support the notion that caregiver-directed language enrichment interventions can change home language environments of D/HH children from low-SES backgrounds. Further longitudinal studies are necessary.

Confabulations: a conceptual history.

PubMed

Berrios, G E

1998-12-01

Confabulations are inaccurate or false narratives purporting to convey information about world or self. It is the received view that they are uttered by subjects intent on "covering up" for a putative memory deficit. The epidemiology of confabulations is unknown. Speculated causes include amnesia, embarrassment, "frontal lobe" damage, a subtype of "personality", a dream-like event, and a disturbance of the self. Historical analysis shows that "confabulation" was constructed at the turn of the century as part of a network of concepts (e.g. delusion, fixed idea, etc.) meant to capture narratives with dubious content. This paper deals with the history of the construction of the word and concept of confabulation and with earlier recognitions of the behaviours that serve as their referent and puts forward a model based on historical data. Two phenomena are included under "confabulation": "untrue" utterances by subjects with memory impairment and "fantastic" utterances marshalled with conviction by subjects suffering from psychoses and no memory deficit. Under different disguises, the "covering up" or "gap filling" hypothesis is still going strong. Although superficially plausible, it poses problems in regards to the issue of "awareness of purpose": if full awareness is presumed then the semantics of the concept of "purpose" is severely stretched and confabulations cannot be differentiated from delusions.

The Carina Project. VI. The Helium-burning Variable Stars

NASA Astrophysics Data System (ADS)

Coppola, G.; Stetson, P. B.; Marconi, M.; Bono, G.; Ripepi, V.; Fabrizio, M.; Dall'Ora, M.; Musella, I.; Buonanno, R.; Ferraro, I.; Fiorentino, G.; Iannicola, G.; Monelli, M.; Nonino, M.; Pulone, L.; Thévenin, F.; Walker, A. R.

2013-09-01

We present new optical (BVI) time-series data for the evolved variable stars in the Carina dwarf spheroidal galaxy. The quality of the data and the observing strategy allowed us to identify 14 new variable stars. Eight out of the 14 are RR Lyrae (RRL) stars, 4 are Anomalous Cepheids (ACs), and 2 are geometrical variables. Comparison of the period distribution for the entire sample of RRLs with similar distributions in nearby dwarf spheroidal galaxies and in the Large Magellanic Cloud indicates that the old stellar populations in these systems share similar properties. This finding is also supported by the RRL distribution in the Bailey diagram. On the other hand, the period distribution and the Bailey diagram of ACs display significant differences among the above stellar systems. This evidence suggests that the properties of intermediate-age stellar populations might be affected both by environmental effects and structural parameters. We use the BV Period-Wesenheit (PW) relation of RRLs together with evolutionary prescriptions and find a true distance modulus of 20.09 ± 0.07 (intrinsic) ± 0.1 (statistical) mag that agrees quite well with similar estimates available in the literature. We identified four peculiar variables. Taking into account their position in the Bailey diagram and in the BV PW relation, two of them (V14 and V149) appear to be candidate ACs, while two (V158 and V182) might be peculiar RRLs. In particular, the variable V158 has a period and a V-band amplitude very similar to the low-mass RRL—RRLR-02792—recently identified by Pietrzyński et al. in the Galactic bulge. Based on images collected with the MOSAICII camera available at the CTIO 4 m Blanco telescope, La Serena (2003B-0051, 2004B-0227, and 2005B-0092; PI: A. R. Walker) and in part with the WFI available at the 2.2 m MPG/ESO telescope (A064.L-0327) and with images obtained from the ESO/ST-ECF Science Archive Facility.

Relation between Plasmodium falciparum asymptomatic infection and malaria attacks in a cohort of Senegalese children

PubMed Central

Le Port, Agnès; Cot, Michel; Etard, Jean-François; Gaye, Oumar; Migot-Nabias, Florence; Garcia, André

2008-01-01

Background It is important to establish whether or not the presence of malaria parasites in peripheral blood of asymptomatic individuals is a predictor of future clinical mild malaria attacks (MMA). The aim of this study was to determine how an asymptomatic positive thick blood smear could be related to the occurrence of a MMA during the nine following days. Methods The study was conducted in a cohort of 569 Senegalese children, who were investigated for Plasmodium falciparum asymptomatic carriage at two different times of the transmission season, the beginning (September) and the end (November). The occurrence of MMA was investigated in asymptomatic carriers and non-carriers, every three days for nine consecutive days. Survival analysis was performed and risk estimates were calculated by Cox proportional hazards model. Results At the beginning of the transmission season, 27.8% (147/529) of the children were asymptomatic carriers (ACs) and 5.4% (8/147) of MMA occurred among these, versus 1% (4/382) among non-carriers (RR = 5.32; IC = [1.56–18.15], p = 0.008). At the end of the transmission season, the frequency of asymptomatic carriers was similar to that observed at the beginning of the season (31.9%, p = 0.15), but no MMA was detected during this period. Conclusion A significant association between P. falciparum asymptomatic carriage and the occurrence of MMA at the beginning of the transmission season was demonstrated, with a five-fold increase in the risk of developing a MMA in ACs. In the context of a possible distribution of IPTc in the future, drug strategies may have dramatic consequences due to the existence of ACs (both long term and short term), as they seem to play an important role in the individual protection to malaria, in the most exposed age groups. PMID:18823542

Cell-type specificity of lung cancer associated with low-dose soil heavy metal contamination in Taiwan: An ecological study

PubMed Central

2013-01-01

Background Numerous studies have examined the association between heavy metal contamination (including arsenic [As], cadmium [Cd], chromium [Cr], copper [Cu], mercury [Hg], nickel [Ni], lead [Pb], and zinc [Zn]) and lung cancer. However, data from previous studies on pathological cell types are limited, particularly regarding exposure to low-dose soil heavy metal contamination. The purpose of this study was to explore the association between soil heavy metal contamination and lung cancer incidence by specific cell type in Taiwan. Methods We conducted an ecological study and calculated the annual averages of eight soil heavy metals (i.e., As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) by using data from the Taiwan Environmental Protection Administration from1982 to 1986. The age-standardized incidence rates of lung cancer according to two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]) were obtained from the National Cancer Registry Program conducted in Taiwan from 2001 to 2005. A geographical information system was used to plot the maps of soil heavy metal concentration and lung cancer incidence rates. Poisson regression models were used to obtain the adjusted relative ratios (RR) and 95% confidence intervals (CI) for the lung cancer incidence associated with soil heavy metals. Results For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose–response relationship. However, for lung AC, only Cu and Ni had a significant dose–response relationship. As for females, those achieving a statistically significant dose–response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC. Conclusion The current study suggests that a dose–response relationship exists between low-dose soil heavy metal concentration and lung cancer occurrence by specific cell-type; however, the relevant mechanism should be explored further. PMID:23575356

The Effects of Electrical Stimuli on Calcium Change and Histamine Release in Rat Basophilic Leukemia Mast Cells

NASA Astrophysics Data System (ADS)

Zhu, Dan; Wu, Zu-Hui; Chen, Ji-Yao; Zhou, Lu-Wei

2013-06-01

We apply electric fields at different frequencies of 0.1, 1, 10 and 100 kHz to the rat basophilic leukemia (RBL) mast cells in calcium-containing or calcium-free buffers. The stimuli cause changes of the intracellular calcium ion concentration [Ca2+]i as well as the histamine. The [Ca2+]i increases when the frequency of the external electric field increases from 100 Hz to 10 kHz, and then decreases when the frequency further increases from 10 kHz to 100 kHz, showing a peak at 100 kHz. A similar frequency dependence of the histamine release is also found. The [Ca2+]i and the histamine releases at 100 Hz are about the same as the values of the control group with no electrical stimulation. The ruthenium red (RR), an inhibitor to the TRPV (transient receptor potential (TRP) family V) channels across the cell membrane, is used in the experiment to check whether the electric field stimuli act on the TRPV channels. Under an electric field of 10 kHz, the [Ca2+]i in a calcium-concentration buffer is about 3.5 times as much as that of the control group with no electric stimulation, while the [Ca2+]i in a calcium-free buffer is only about 2.2 times. Similar behavior is also found for the histamine release. RR blockage effect on the [Ca2+]i decrease is statistically significant (~75%) when mast cells in the buffer with calcium are stimulated with a 10 kHz electric field in comparison with the result without the RR treatment. This proves that TRPVs are the channels that calcium ions inflow through from the extracellular environment under electrical stimuli. Under this condition, the histamine is also released following a similar way. We suggest that, as far as an electric stimulation is concerned, an application of ac electric field of 10 kHz is better than other frequencies to open TRPV channels in mast cells, and this would cause a significant calcium influx resulting in a significant histamine release, which could be one of the mechanisms for electric therapy.

A Development of a System Enables Character Input and PC Operation via Voice for a Physically Disabled Person with a Speech Impediment

NASA Astrophysics Data System (ADS)

Tanioka, Toshimasa; Egashira, Hiroyuki; Takata, Mayumi; Okazaki, Yasuhisa; Watanabe, Kenzi; Kondo, Hiroki

We have designed and implemented a PC operation support system for a physically disabled person with a speech impediment via voice. Voice operation is an effective method for a physically disabled person with involuntary movement of the limbs and the head. We have applied a commercial speech recognition engine to develop our system for practical purposes. Adoption of a commercial engine reduces development cost and will contribute to make our system useful to another speech impediment people. We have customized commercial speech recognition engine so that it can recognize the utterance of a person with a speech impediment. We have restricted the words that the recognition engine recognizes and separated a target words from similar words in pronunciation to avoid misrecognition. Huge number of words registered in commercial speech recognition engines cause frequent misrecognition for speech impediments' utterance, because their utterance is not clear and unstable. We have solved this problem by narrowing the choice of input down in a small number and also by registering their ambiguous pronunciations in addition to the original ones. To realize all character inputs and all PC operation with a small number of words, we have designed multiple input modes with categorized dictionaries and have introduced two-step input in each mode except numeral input to enable correct operation with small number of words. The system we have developed is in practical level. The first author of this paper is physically disabled with a speech impediment. He has been able not only character input into PC but also to operate Windows system smoothly by using this system. He uses this system in his daily life. This paper is written by him with this system. At present, the speech recognition is customized to him. It is, however, possible to customize for other users by changing words and registering new pronunciation according to each user's utterance.

Measurement of emission cross sections for n = 3 → 2 transitions in Neon-like Fe XVII and Ni XIX ions

NASA Astrophysics Data System (ADS)

Lockard, Tom; Brown, Gregory V.; Hell, Natalie; Scofield, J. H.; Beiersdorfer, Peter; Porter, Frederick Scott; Kilbourne, Caroline; Kelley, Richard L.; Leutenegger, Maurice A.; Betancourt-Martinez, Gabriele

2018-06-01

The absolute excitation cross sections of the strong 1s2 2s2 2p51/2 3d3/2 1P1 → 1s2 2s2 2p6 1S0 and 1s2 2s2 2p53/2 3d5/2 3D1 → 1s2 2s2 2p6 1S0 strong resonance and intercombination lines, commonly known as 3C and 3D, have been measured in neon-like Fe16+ and Ni18+. These measurements were carried out at the Lawrence Livermore National Laboratory's EBIT-I electron beam ion trap facility using the EBIT Calorimeter Spectrometer (ECS) quantum microcalorimeter and a flat crystal spectrometer. The absolute excitation cross sections were determined by normalizing the measured spectrum to the X-ray emission from radiative recombination. The direct excitation lines 3C and 3D and radiative recombination (RR) lines were measured simultaneously using the ECS. By normalizing the measured RR flux to their theoretical cross sections, the emission from lines 3C and 3D was made absolute. Using simultaneous measurements from the higher resolution flat crystal spectrometer, it was possible to check for potential blends from lower charge states. Results of our measurements including comparison to theory, will be presented.This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Participation of the extracellular domain in (pro)renin receptor dimerization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suzuki-Nakagawa, Chiharu; Nishimura, Misa; Tsukamoto, Tomoko

Highlights: • The (pro)renin receptor [(P)RR] is a regulator of the renin–angiotensin system. • The region responsible for (P)RR dimerization was investigated. • (P)RR extracellular domain constructs were retained intracellularly. • The extracellular domain of (P)RR is responsible for its dimerization. • Novel insight into the regulatory mechanism of soluble (P)RR secretion is provided. - Abstract: The (pro)renin receptor [(P)RR] induces the catalytic activation of prorenin, as well as the activation of the mitogen-activated protein kinase (MAPK) signaling pathway; as such, it plays an important regulatory role in the renin–angiotensin system. (P)RR is known to form a homodimer, but themore » region participating in its dimerization is unknown. Using glutathione S-transferase (GST) as a carrier protein and a GST pull-down assay, we investigated the interaction of several (P)RR constructs with full-length (FL) (P)RR in mammalian cells. GST fusion proteins with FL (P)RR (GST-FL), the C-terminal M8-9 fragment (GST-M8-9), the extracellular domain (ECD) of (P)RR (GST-ECD), and the (P)RR ECD with a deletion of 32 amino acids encoded by exon 4 (GST-ECDd4) were retained intracellularly, whereas GST alone was efficiently secreted into the culture medium when transiently expressed in COS-7 cells. Immunofluorescence microscopy showed prominent localization of GST-ECD to the endoplasmic reticulum. The GST pull-down analysis revealed that GST-FL, GST-ECD, and GST-ECDd4 bound FLAG-tagged FL (P)RR, whereas GST-M8-9 showed little or no binding when transiently co-expressed in HEK293T cells. Furthermore, pull-down analysis using His-tag affinity resin showed co-precipitation of soluble (P)RR with FL (P)RR from a stable CHO cell line expressing FL h(P)RR with a C-terminal decahistidine tag. These results indicate that the (P)RR ECD participates in dimerization.« less

Acoustic sensor versus electrocardiographically derived respiratory rate in unstable trauma patients.

PubMed

Yang, Shiming; Menne, Ashley; Hu, Peter; Stansbury, Lynn; Gao, Cheng; Dorsey, Nicolas; Chiu, William; Shackelford, Stacy; Mackenzie, Colin

2017-08-01

Respiratory rate (RR) is important in many patient care settings; however, direct observation of RR is cumbersome and often inaccurate, and electrocardiogram-derived RR (RR ECG ) is unreliable. We asked how data derived from the first 15 min of RR recording after trauma center admission using a novel acoustic sensor (RR a ) would compare to RR ECG and to end-tidal carbon dioxide-based RR ([Formula: see text]) from intubated patients, the "gold standard" in predicting life-saving interventions in unstable trauma patients. In a convenience sample subset of trauma patients admitted to our Level 1 trauma center, enrolled in the ONPOINT study, and monitored with RR ECG , some of whom also had [Formula: see text] data, we collected RRa using an adhesive sensor with an integrated acoustic transducer (Masimo RRa™). Using Bland-Altman analysis of area under the receiver operating characteristic (AUROC) curves, we compared the first 15 min of continuous RRa and RR ECG to [Formula: see text] and assessed the performance of these three parameters compared to the Revised Trauma Score (RTS) in predicting blood transfusion 3, 6, and 12 h after admission. Of the 1200 patients enrolled in ONPOINT from December 2011 to May 2013, 1191 had RR ECG data recorded in the first 15 min, 358 had acoustic monitoring, and 14 of the latter also had [Formula: see text]. The three groups did not differ demographically or in mechanism of injury. RR a showed less bias (0.8 vs. 6.9) and better agreement than RR ECG when compared to [Formula: see text]. At [Formula: see text] 10-29 breaths per minute, RR a was more likely to be the same as [Formula: see text] and assign the same RTS. In predicting transfusion, features derived from RR a and RR ECG gave AUROCs 0.59-0.66 but with true positive rate 0.70-0.89. RR a monitoring is a non-invasive option to glean valid RR data to assist clinical decision making and could contribute to prediction models in non-intubated unstable trauma patients.

An experimental study on providing a scientific evidence for seven-time alcohol-steaming of Rhei Rhizoma when clinically used.

PubMed

Sim, Yeomoon; Oh, Hyein; Oh, Dal-Seok; Kim, Namkwon; Gu, Pil Sung; Choi, Jin Gyu; Kim, Hyo Geun; Kang, Tong Ho; Oh, Myung Sook

2015-10-27

Rhei Rhizoma (RR) has been widely used as laxative and processed to alter its therapeutic actions or reduce its side effects. In this study, we evaluated experimentally the clinical application guideline that RR should be alcohol-steamed seven times before being used in elderly patients, as described in Dongeuibogam, the most famous book on Korean traditional medicine. Unprocessed RR (RR-U) was soaked in rice wine, steamed and then fully dried (RR-P1). The process was repeated four (RR-P4) or seven times (RR-P7). Reversed-phase high-performance liquid chromatography was used to determine the RR-U, RR-P1, RR-P4 and RR-P7 (RRs) constituents. To evaluate the effect of RRs on liver toxicity, human hepatoma cells (HepG2) were treated with RRs at 100 μg/mL for 4 h and then cell viabilities were measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. To confirm the effects in vivo, 5-week-old male Sprague-Dawley rats were treated with RRs at 3 g/kg/day for 21 days. Body weight and serum biochemical parameters were measured and liver histology was assessed. The levels of sennosides decreased in processed RRs in an iteration-dependent manner, while the emodin level was unaffected. In HepG2 cells, cell viability was reduced with RR-U, while the toxicity decreased according to the number of processing cycles. The changes in body weight, relative liver weight and liver enzymes of RR-U-treated rats were reduced in processed RRs-treated rats. Histopathological analysis indicated swelling and cholestasis improved following seven times alcohol-steaming cycles. These results provide experimental evidence that RR-P7 almost completely reduces RR hepatotoxicity.

Letter Knowledge in Parent–Child Conversations

PubMed Central

Robins, Sarah; Treiman, Rebecca; Rosales, Nicole

2014-01-01

Learning about letters is an important component of emergent literacy. We explored the possibility that parent speech provides information about letters, and also that children’s speech reflects their own letter knowledge. By studying conversations transcribed in CHILDES (MacWhinney, 2000) between parents and children aged one to five, we found that alphabetic order influenced use of individual letters and letter sequences. The frequency of letters in children’s books influenced parent utterances throughout the age range studied, but children’s utterances only after age two. Conversations emphasized some literacy-relevant features of letters, such as their shapes and association with words, but not letters’ sounds. Describing these patterns and how they change over the preschool years offers important insight into the home literacy environment. PMID:25598577

Interaction order and anxiety disorder: A 'Batesonian' heuristic of speaking patterns during psychotherapy.

PubMed

Streeck, Jürgen

2011-01-01

This paper describes speaking practices enacted by young female in-patients during psychotherapy sessions. The patients are in treatment for anxiety and panic disorders (social phobias). The practices involve prosodic, lexical and pragmatic aspects of utterance construction. An effect that they share is that the speaker's embodied presence in her talk and her epistemic commitment to it are reduced as the utterance progresses. The practices are interpreted in light of Bateson's interactional theory of character formation: as elements of a self-sustaining system Angst (anxiety). The study has grown out of an interdisciplinary effort to explore possible relationships between types of anxiety and the communicative and linguistic patterns by which patients describe panic attacks and other highly emotional experiences.

Evaluation of Spectral and Prosodic Features of Speech Affected by Orthodontic Appliances Using the Gmm Classifier

NASA Astrophysics Data System (ADS)

Přibil, Jiří; Přibilová, Anna; Ďuračkoá, Daniela

2014-01-01

The paper describes our experiment with using the Gaussian mixture models (GMM) for classification of speech uttered by a person wearing orthodontic appliances. For the GMM classification, the input feature vectors comprise the basic and the complementary spectral properties as well as the supra-segmental parameters. Dependence of classification correctness on the number of the parameters in the input feature vector and on the computation complexity is also evaluated. In addition, an influence of the initial setting of the parameters for GMM training process was analyzed. Obtained recognition results are compared visually in the form of graphs as well as numerically in the form of tables and confusion matrices for tested sentences uttered using three configurations of orthodontic appliances.

Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study.

PubMed

Cazenave, Jimena; Wunderlin, Daniel Alberto; de Los Angeles Bistoni, María; Amé, María Valeria; Krause, Eberhard; Pflugmacher, Stephan; Wiegand, Claudia

2005-10-15

The uptake and accumulation of microcystin-RR (MC-RR) in fish was investigated under laboratory conditions and in wild fish. Jenynsia multidentata and Corydoras paleatus were exposed for 24h to 50mug/L MC-RR dissolved in water. After exposure, liver, gill, brain, intestine, gall bladder, blood and muscle were analyzed for MC-RR by HPLC and analysis confirmed by LC-ESI-TOF-MS spectrometry. Furthermore, wild individuals of Odontesthes bonariensis were sampled from the eutrophic, cyanobacteria-containing San Roque reservoir, and analyzed for the presence of MC-RR in liver, gill, intestine, and muscle. MC-RR was found in liver, gills, and muscle of all exposed and wild fish, while in C. paleatus MC-RR was also present in the intestine. Moreover, we found presence of MC-RR in brain of J. multidentata. Results indicate that MC-RR uptake might occur at two different organs: intestine and gills, through either feeding (including drinking) or respiratory activities. This suggests that MC-RR is taken into the blood stream after absorption, and distributed to different tissues. The liver showed the major bioaccumulation of MC-RR in both experimentally exposed and wild individuals, with muscle of wild fish showing relative high amounts of this toxin in comparison with those exposed in the laboratory; though MC-RR was present in muscle of fish exposed for 24h. The amount of MC-RR in muscle of O. bonariensis exceeded the value suggested by WHO to be safe, thus causing a health risk to persons consuming fish as a result of chronic exposure to microcystin. Gills also showed bioaccumulation of MC-RR, raising questions on the mechanism involved in the possible uptake of MC-RR through gills as well as on its accumulation in this organ. Although MC-LR has been reported in brain of fish, this is the first report confirming the presence of MC-RR in this organ, which means that both toxins are able to cross the blood-brain barrier. These findings also raise questions on the probable neurotoxicity of microcystins.

A metronome for pacing manual ventilation in a neonatal resuscitation simulation.

PubMed

Cocucci, Cecilia; Madorno, Matías; Aguilar, Adriana; Acha, Leila; Szyld, Edgardo; Musante, Gabriel

2015-01-01

During manual positive pressure ventilation (PPV), delivering a recommended respiratory rate (RR) is operator dependent. We tested the efficacy of a metronome as a standardised method to improve the accuracy of delivered RR during manual PPV in a neonatal resuscitation simulation. We conducted a blinded simulation in two consecutive stages. Using a self-inflating bag, 36 CPR trained operators provided PPV to a modified neonatal manikin via an endotracheal tube. Pressure and flow signals were captured by a respiratory function monitor. In the first standard stage, participants delivered RR as they would in delivery room. Prior to the second stage, they were asked about what their target RR had been and a metronome was set to that target. Subsequently, operators repeated PPV attempting to coordinate their delivered RR with the metronome. To evaluate accuracy we generated the variable RR Gap as the absolute difference between delivered and target RR. The primary outcome was the difference in RR Gap between stages. Mean (SD) target RR was 50 (8.7) inflations/min. During the initial stage, median (IQR) RR Gap was 11.6 (4.7-18.3) inflations/min and 20/36 participants (55.5%) had a mean delivered RR beyond the recommended range. When paced by the metronome, RR Gap was reduced to 0.2 (0.1-0.4) inflations/min and 32/36 participants (89%) fell within the recommended range. The use of a metronome improved the accuracy of delivered RR during manual PPV. Novel approaches to deliver an accurate RR during manual PPV need to be tested in more realistic scenarios. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Possible contribution of (pro)renin receptor to development of gestational diabetes mellitus.

PubMed

Bokuda, Kanako; Ichihara, Atsuhiro

2014-12-15

(Pro)renin receptor [(P)RR], a receptor for renin and prorenin, was first cloned in 2002. Since then, the pathophysiological roles of (P)RR have been growing concerns. (P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin, leading to the tissue renin-angiotensin system activation and the intracellular signalings. It is now also known to play an important role as vacuolar H(+)-ATPase associated protein, involving in Wnt signaling, main component of embryonic development. Extracellular domain of full-length (P)RR is cleaved in golgi-complex forming soluble (P)RR [s(P)RR]. The s(P)RR is now possible to be measured in human blood and urine. It is now measured in different pathophysiological states, and recent study showed that elevated plasma s(P)RR levels in the early stage of pregnancies are associated with higher incidence of gestational diabetes mellitus later in the pregnancies. Plasma s(P)RR levels of neonates are known to be higher than that of adults. It was also shown that, increased s(P)RR concentrations in cord blood, associated with a lower small for gestational age birth likelihood. These data suggests the involvement of (P)RR in embryo's growth. In this review article, we attempt to figure out the possible pathophysiological roles of the (P)RR in maternal glucose intolerance and embryo's growth, through reviewing previous studies.

Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients

PubMed Central

Amari, Yoshifumi; Morimoto, Satoshi; Nakajima, Fumitaka; Ando, Takashi; Ichihara, Atsuhiro

2016-01-01

The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis. The aim of this study was to investigate the relationships between serum s(P)RR levels and background factors, including indices of atherosclerosis, in hemodialysis patients. Serum s(P)RR levels were measured in hemodialysis patients and clearance of s(P)RR through the membrane of the dialyzer was examined. Furthermore, relationships between serum s(P)RR levels and background factors were assessed. Serum s(P)RR levels were significantly higher in hemodialysis patients (30.4 ± 6.1 ng/ml, n = 258) than those in subjects with normal renal function (21.4 ± 6.2 ng/ml, n = 39, P < 0.0001). Clearance of s(P)RR and creatinine were 56.9 ± 33.5 and 147.6 ± 9.50 ml/min, respectively. Serum s(P)RR levels were significantly higher in those with ankle-brachial index (ABI) of < 0.9, an indicator of severe atherosclerosis, than those with ABI of ≥ 0.9 (32.2 ± 5.9 and 30.1 ± 6.2 ng/ml, respectively, P < 0.05). An association between low ABI and high serum s(P)RR levels was observed even after correction for age, history of smoking, HbA1c, and LDL-C. Serum s(P)RR levels were significantly higher in hemodialysis patients when compared with subjects with normal renal function, although s(P)RR is dialyzed to some extent, but to a lesser extent than creatinine. High serum s(P)RR levels may be associated with atherosclerosis independent of other risk factors, suggesting that serum s(P)RR could be used as a marker for atherosclerotic conditions in hemodialysis patients. PMID:27367528

Proceedings of the International Conference on the Numerical Simulation of Plasmas (14th) Held in Annapolis, Maryland on September 3-6, 1991

DTIC Science & Technology

1991-01-01

2 - tý a .5 .= . A ’. 2 0’.. o SS ’.. . t I -. .5 :. C, 0 Oý 0 r go %C a -0 c SS 2L 2E "t-iocogo" 0 IS F6 a c So a,, 3 IL So E 2 Q Qo’ V E r r 0c c...4 ar 0 -C ’ aCCa 0 W. , US w .2 00 ~ i; E 2 ~ . o.Z-. - w a~C -0 e0 E4 Em 12 *U - -.E 2 c - act , 0 3 2. , =- b ! .. E0 E 2- ccZZ cT, w~. ýt 0 w C...00 o- c 00 F6 ~ -02 C -4 a. 71 if )A 1 G a -2 - a d= . Cc 00 -V -0 0 P- . -- Z - 2 - q 0 0J2 2 a c x -a WO.~. 0 C;W n-a- - 0 1 o ao RR 0 if * . -I

Children with Autism Understand Indirect Speech Acts: Evidence from a Semi-Structured Act-Out Task

PubMed Central

Kissine, Mikhail; Cano-Chervel, Julie; Carlier, Sophie; De Brabanter, Philippe; Ducenne, Lesley; Pairon, Marie-Charlotte; Deconinck, Nicolas; Delvenne, Véronique; Leybaert, Jacqueline

2015-01-01

Children with Autism Spectrum Disorder are often said to present a global pragmatic impairment. However, there is some observational evidence that context-based comprehension of indirect requests may be preserved in autism. In order to provide experimental confirmation to this hypothesis, indirect speech act comprehension was tested in a group of 15 children with autism between 7 and 12 years and a group of 20 typically developing children between 2:7 and 3:6 years. The aim of the study was to determine whether children with autism can display genuinely contextual understanding of indirect requests. The experiment consisted of a three-pronged semi-structured task involving Mr Potato Head. In the first phase a declarative sentence was uttered by one adult as an instruction to put a garment on a Mr Potato Head toy; in the second the same sentence was uttered as a comment on a picture by another speaker; in the third phase the same sentence was uttered as a comment on a picture by the first speaker. Children with autism complied with the indirect request in the first phase and demonstrated the capacity to inhibit the directive interpretation in phases 2 and 3. TD children had some difficulty in understanding the indirect instruction in phase 1. These results call for a more nuanced view of pragmatic dysfunction in autism. PMID:26551648

Utterance Detection by Intraoral Acceleration Sensor

NASA Astrophysics Data System (ADS)

Saiki, Tsunemasa; Takizawa, Yukako; Hashizume, Tsutomu; Higuchi, Kohei; Fujita, Takayuki; Maenaka, Kazusuke

In order to establish monitoring systems for home health in elderly people including the prevention of mental illness, we investigated the acceleration of teeth in utterance on the assumption that an acceleration sensor can be implanted into an artificial denture in the near future. In the experiment, an acceleration sensor was fixed in front of the central incisors on the lower jaw by using a denture adhesive, and female and male subjects spoke five Japanese vowels. We then measured the teeth accelerations in three (front-to-back, right-to-left and top-to-bottom) axes and conducted frequency analyses. The result showed that high power spectral densities of the teeth accelerations were observed at a low frequency range of 2-10Hz (both the female and the male) and at a high frequency range of 200-300Hz (the female) or 100-150 Hz (the male). The low and high frequency components indicate movements of the lower jaw and voice sounds by bone conduction, respectively. Especially in the top-to-bottom axis of the central incisor, the frequency component appeared to be significant. Therefore, we found that utterance can be efficiently detected using the acceleration in this axis. We also found that three conditions of normal speech, lip synchronizing and humming can be recognized by using frequency analysis of the acceleration in the top-to-bottom axis of the central incisor.

The effects of in-service education to promote emergent literacy in child care centers: a feasibility study.

PubMed

Girolametto, Luigi; Weitzman, Elaine; Lefebvre, Pascal; Greenberg, Janice

2007-01-01

The purpose of this study was to determine the feasibility of a 2-day in-service education program for (a) promoting the use of two emergent literacy strategies by early childhood educators and (b) increasing children's responses to these strategies. Sixteen early childhood educators were randomly assigned to an experimental and a control group. The experimental in-service program sought to increase educators' use of abstract utterances and print references. Educators were videotaped with small groups of preschoolers during storybook reading and a post-story craft activity. Pretest and posttest videotapes were coded to yield rates of abstract language, verbal print references, and children's responses. In comparison to the control group, educators in the experimental program used more abstract utterances that elicited talk about emotions and children's past experiences during storybook reading. They also used significantly more print references during a post-story craft activity. In addition, children in the experimental group responded more often with appropriate responses to abstract utterances and print references in comparison to children in the control group. A 2-day in-service education program resulted in short-term behavioral changes in educators' use of abstract language and print references. Suggestions for improving instruction include providing opportunities for classroom practice with feedback, modeling the use of strategies in classroom routines, and long-term mentoring of educators to promote retention of gains.

First insights into the vocal repertoire of infant and juvenile Southern white rhinoceros.

PubMed

Linn, Sabrina N; Boeer, Michael; Scheumann, Marina

2018-01-01

Describing vocal repertoires represents an essential step towards gaining an overview about the complexity of acoustic communication in a given species. The analysis of infant vocalisations is essential for understanding the development and usage of species-specific vocalisations, but is often underrepresented, especially in species with long inter-birth intervals such as the white rhinoceros. Thus, this study aimed for the first time to characterise the infant and juvenile vocal repertoire of the Southern white rhinoceros and to relate these findings to the adult vocal repertoire. The behaviour of seven mother-reared white rhinoceros calves (two males, five females) and one hand-reared calf (male), ranging from one month to four years, was simultaneously audio and video-taped at three zoos. Normally reared infants and juveniles uttered four discriminable call types (Whine, Snort, Threat, and Pant) that were produced in different behavioural contexts. All call types were also uttered by the hand-reared calf. Call rates of Whines, but not of the other call types, decreased with age. These findings provide the first evidence that infant and juvenile rhinoceros utter specific call types in distinct contexts, even if they grow up with limited social interaction with conspecifics. By comparing our findings with the current literature on vocalisations of adult white rhinoceros and other solitary rhinoceros species, we discuss to which extent differences in the social lifestyle across species affect acoustic communication in mammals.

Is young children's recognition of pretense metarepresentational or merely behavioral? Evidence from 2- and 3-year-olds' understanding of pretend sounds and speech.

PubMed

Friedman, Ori; Neary, Karen R; Burnstein, Corinna L; Leslie, Alan M

2010-05-01

When young children observe pretend-play, do they interpret it simply as a type of behavior, or do they infer the underlying mental state that gives the behavior meaning? This is a long-standing question with deep implications for how "theory on mind" develops. The two leading accounts of shared pretense give opposing answers. The behavioral theory proposes that children represent pretense as a form of behavior (behaving in a way that would be appropriate if P); the metarepresentational theory argues that children instead represent pretense via the early concept PRETEND. A test between these accounts is provided by children's understanding of pretend sounds and speech. We report the first experiments directly investigating this understanding. In three experiments, 2- and 3-year-olds' listened to requests that were either spoken normally, or with the pretense that a teddy bear was uttering them. To correctly fulfill the requests, children had to represent the normal utterance as the experimenter's, and the pretend utterances as the bear's. Children succeeded at both ages, suggesting that they can represent pretend speech (the requests) as coming from counterfactual sources (the bear rather than the experimenter). We argue that this is readily explained by the metarepresentational theory, but harder to explain if children are behaviorists about pretense. Copyright 2010 Elsevier B.V. All rights reserved.

A magnetic resonance imaging study on the articulatory and acoustic speech parameters of Malay vowels

PubMed Central

2014-01-01

The phonetic properties of six Malay vowels are investigated using magnetic resonance imaging (MRI) to visualize the vocal tract in order to obtain dynamic articulatory parameters during speech production. To resolve image blurring due to the tongue movement during the scanning process, a method based on active contour extraction is used to track tongue contours. The proposed method efficiently tracks tongue contours despite the partial blurring of MRI images. Consequently, the articulatory parameters that are effectively measured as tongue movement is observed, and the specific shape of the tongue and its position for all six uttered Malay vowels are determined. Speech rehabilitation procedure demands some kind of visual perceivable prototype of speech articulation. To investigate the validity of the measured articulatory parameters based on acoustic theory of speech production, an acoustic analysis based on the uttered vowels by subjects has been performed. As the acoustic speech and articulatory parameters of uttered speech were examined, a correlation between formant frequencies and articulatory parameters was observed. The experiments reported a positive correlation between the constriction location of the tongue body and the first formant frequency, as well as a negative correlation between the constriction location of the tongue tip and the second formant frequency. The results demonstrate that the proposed method is an effective tool for the dynamic study of speech production. PMID:25060583

A magnetic resonance imaging study on the articulatory and acoustic speech parameters of Malay vowels.

PubMed

Zourmand, Alireza; Mirhassani, Seyed Mostafa; Ting, Hua-Nong; Bux, Shaik Ismail; Ng, Kwan Hoong; Bilgen, Mehmet; Jalaludin, Mohd Amin

2014-07-25

The phonetic properties of six Malay vowels are investigated using magnetic resonance imaging (MRI) to visualize the vocal tract in order to obtain dynamic articulatory parameters during speech production. To resolve image blurring due to the tongue movement during the scanning process, a method based on active contour extraction is used to track tongue contours. The proposed method efficiently tracks tongue contours despite the partial blurring of MRI images. Consequently, the articulatory parameters that are effectively measured as tongue movement is observed, and the specific shape of the tongue and its position for all six uttered Malay vowels are determined.Speech rehabilitation procedure demands some kind of visual perceivable prototype of speech articulation. To investigate the validity of the measured articulatory parameters based on acoustic theory of speech production, an acoustic analysis based on the uttered vowels by subjects has been performed. As the acoustic speech and articulatory parameters of uttered speech were examined, a correlation between formant frequencies and articulatory parameters was observed. The experiments reported a positive correlation between the constriction location of the tongue body and the first formant frequency, as well as a negative correlation between the constriction location of the tongue tip and the second formant frequency. The results demonstrate that the proposed method is an effective tool for the dynamic study of speech production.

Doctor-patient communication: a comparison between telemedicine consultation and face-to-face consultation.

PubMed

Liu, Xiao; Sawada, Yoshie; Takizawa, Takako; Sato, Hiroko; Sato, Mahito; Sakamoto, Hironosuke; Utsugi, Toshihiro; Sato, Kunio; Sumino, Hiroyuki; Okamura, Shinichi; Sakamaki, Tetsuo

2007-01-01

The objective of this study was to compare doctor-patient communications in clinical consultations via telemedicine technology to doctor-patient communications in face-to-face clinical consultations. Five doctors who had been practicing internal medicine for 8 to 18 years, and twenty patients were enrolled in this study; neither doctors nor patients had previous experience of telemedicine. The patients received both a telemedicine consultation and a face-to-face consultation. Three measures--video observation, medical record volume, and participants' satisfaction--were used for the assessment. It was found that the time spent on the telemedicine consultation was substantially longer than the time spent on the face-to-face consultation. No statistically significant differences were found in the number of either closed or open-ended questions asked by doctors between both types of consultation. Empathy-utterances, praise-utterances, and facilitation-utterances were, however, seen less in the telemedicine consultations than in the face-to-face consultations. The volume of the medical records was statistically smaller in the telemedicine consultations than in the face-to-face consultations. Patients were satisfied with the telemedicine consultation, but doctors were dissatisfied with it and felt hampered by the communication barriers. This study suggests that new training programs are needed for doctors to develop improved communication skills and the ability to express empathy in telemedicine consultations.

Growth performance, carcass and noncarcass traits and meat quality of Barbarine lambs fed rosemary distillation residues.

PubMed

Yagoubi, Y; Hajji, H; Smeti, S; Mahouachi, M; Kamoun, M; Atti, N

2018-02-15

The aim of this experiment was to study the effect of total replacement of oat hay by rosemary distillation residues (RR) on growth, carcass characteristics and meat quality of Barbarine lambs. A total of 21 lambs were divided into three groups. The control group (C) was offered 600 g of oat hay; the RR87 and RR60 groups received 600 g of pellets containing 87% and 60% of RR, respectively. The CP content was 9% and 14% for RR87 and RR60, respectively. All animals were supplemented by 600 g of concentrate. After 77 days of fattening, lambs were slaughtered. The DM and CP intakes were significantly increased with RR diets. The average daily gain was higher (P<0.001), while the feed conversion rate was lower for RR60 and RR87 than C group. The dressing percentage was similar for all groups. The tissular (muscle, fat and bone) and the regional (leg, shoulder, etc.) carcass composition did not differ among groups. The bony organs and gut weights were similar among groups, while functional ones (skin, liver, kidney and testicles) were significantly heavier for both RR groups than control. The ultimate pH, water cooking loss and color variables were similar among groups and the chemical composition (protein, fat, myoglobin, collagen and iron) did not differ also among groups. These results revealed the opportunity of RR use in fattening lambs without adverse effects on carcass and meat characteristics. Moreover, 9% CP in RR pellets are enough given the same growth performance recorded as that of RR with 14% CP.

Principal William Shakespeare

ERIC Educational Resources Information Center

Bromberg, Murray

1975-01-01

This writer suggests some Shakespearian gems for dealing with everyone from reporters to superintendents. You can try your old-time memorization techniques on these apropos utterances--and be prepared for anything. (Editor)

Fourier Decomposition and Properties of the Variable Stars in the Globular Cluster NGC 4833

NASA Astrophysics Data System (ADS)

Reed, Hunter M.; Pajkos, Michael A.; Murphy, Brian W.; Darragh, Andrew

2016-01-01

Globular clusters provide an ideal setting to study stellar evolution of stars of similar composition and age. RR Lyrae stars found in globular clusters have a variety of uses in probing the physical characteristics of the stellar population itself and its evolution. Building upon our previous study, we focus on the RR Lyrae stars in the globular cluster NGC 4833. From March through June 2014, we used the Southeastern Association for Research in Astronomy 0.6-meter telescope located at CTIO to collect nearly 1,500 images of NGC 4833 in the B, V, R, and I bands. Using difference image analysis we identified 40 variable stars. Of these, 20 were RR Lyrae stars with 10 being of type RR0, 7 of type RR1, and 3 of type RR2. Additionally, 6 SX Phe, 5 eclipsing binaries, and 9 long period variables were identified. The average period of the type RR0, RR1, and RR2 type variables were 0.69597 days, 0.39547 days, and 0.30654 days, respectively. The periods of the RR Lyrae stars and ratio of N1/(N0+N1) of 0.41 is indicative of an Oosterhoff Type II cluster. The observations of the RR Lyrae stars were of very high quality and phase coverage allowing us to perform Fourier decomposition of their light curves. From this Fourier decomposition we were able to determine the physical characteristics of the RR Lyrae stars. We found the mean iron abundance to be [Fe/H]JKZW = -1.87 ± 0.06, the mean apparent V-magnitude RR0 and RR1 type variables to be VRR = 15.51 ± 0.11, a mean absolute V-magnitude of MV = 0.636 ± 0.053; and an effective temperature for RR0's and RR1's of log10Teff = 3.797 and log10Teff = 3.855, respectively. The multi-band photometry allowed us to determine the reddening of the cluster, E(B-V) = 0.342 ± 0.021, which resulted in a distance of D(kpc) = 5.91 ± 0.31 to NGC 4833.

Lexically restricted utterances in Russian, german, and english child-directed speech.

PubMed

Stoll, Sabine; Abbot-Smith, Kirsten; Lieven, Elena

2009-01-01

This study investigates the child-directed speech (CDS) of four Russian-, six German, and six English-speaking mothers to their 2-year-old children. Typologically Russian has considerably less restricted word order than either German or English, with German showing more word-order variants than English. This could lead to the prediction that the lexical restrictiveness previously found in the initial strings of English CDS by Cameron-Faulkner, Lieven, and Tomasello (2003) would not be found in Russian or German CDS. However, despite differences between the three corpora that clearly derive from typological differences between the languages, the most significant finding of this study is a high degree of lexical restrictiveness at the beginnings of CDS utterances in all three languages. Copyright © 2009 Cognitive Science Society, Inc.

Antiretroviral Therapy and Nutrition in Southern Africa: Citizenship and the Grammar of Hunger.

PubMed

Cousins, Thomas

2016-01-01

How might we understand and respond to the new forms of hunger that arise with the massive rollout of antiretroviral therapy (ART) for HIV in southern Africa? Rather than 'merely' a technical problem of measurement, medicine or infrastructure, I suggest that a philosophical question arises concerning the relationship between the experience of hunger, the utterances that communicate that experience, and the bodily regimes of well-being and ill-being indexed by such utterances. Taking the gut as a particular kind of mediator of experience, I draw on ethnographic fieldwork conducted in KwaZulu-Natal, South Africa to open up a set of questions on acknowledgment and avoidance. The central question concerns the divergent concepts of 'grammar' that confront the relationship between hunger and ART.

Listeners' comprehension of uptalk in spontaneous speech.

PubMed

Tomlinson, John M; Fox Tree, Jean E

2011-04-01

Listeners' comprehension of phrase final rising pitch on declarative utterances, or uptalk, was examined to test the hypothesis that prolongations might differentiate conflicting functions of rising pitch. In Experiment 1 we found that listeners rated prolongations as indicating more speaker uncertainty, but that rising pitch was unrelated to ratings. In Experiment 2 we found that prolongations interacted with rising pitch when listeners monitored for words in the subsequent utterance. Words preceded by prolonged uptalk were monitored faster than words preceded by non-prolonged uptalk. In Experiment 3 we found that the interaction between rising pitch and prolongations depended on listeners' beliefs about speakers' mental states. Results support the theory that temporal and situational context are important in determining intonational meaning. Copyright © 2010 Elsevier B.V. All rights reserved.

Teaching strategies in inclusive classrooms with deaf students.

PubMed

Cawthon, S W

2001-01-01

The purpose of this study was to investigate teacher speech and educational philosophies in inclusive classrooms with deaf and hearing students. Data were collected from language transcripts, classroom observations, and teacher interviews. Total speech output, Mean Length Utterance, proportion of questions to statements, and proportion of open to closed questions were calculated for each teacher. Teachers directed fewer utterances, on average, to deaf than to hearing students but showed different language patterns on the remaining measures. Inclusive philosophies focused on an individualized approach to teaching, attention to deaf culture, advocacy, smaller class sizes, and an openness to diversity in the classroom. The interpreters' role in the classroom included translating teacher speech, voicing student sign language, mediating communication between deaf students and their peers, and monitoring overall classroom behavior.

The interactional significance of formulas in autistic language.

PubMed

Dobbinson, Sushie; Perkins, Mick; Boucher, Jill

2003-01-01

The phenomenon of echolalia in autistic language is well documented. Whilst much early research dismissed echolalia as merely an indicator of cognitive limitation, later work identified particular discourse functions of echolalic utterances. The work reported here extends the study of the interactional significance of echolalia to formulaic utterances. Audio and video recordings of conversations between the first author and two research participants were transcribed and analysed according to a Conversation Analysis framework and a multi-layered linguistic framework. Formulaic language was found to have predictable interactional significance within the language of an individual with autism, and the generic phenomenon of formulaicity in company with predictable discourse function was seen to hold across the research participants, regardless of cognitive ability. The implications of formulaicity in autistic language for acquisition and processing mechanisms are discussed.

Risk factors for suicide attempt among Israeli Defense Forces soldiers: A retrospective case-control study.

PubMed

Shelef, Leah; Kaminsky, Dan; Carmon, Meytal; Kedem, Ron; Bonne, Omer; Mann, J John; Fruchter, Eyal

2015-11-01

A major risk factor for suicide is suicide attempts. The aim of the present study was to assess risk factors for nonfatal suicide attempts. Methods The study's cohort consisted of 246,814 soldiers who were divided into two groups: soldiers who made a suicide attempt (n=2310; 0.9%) and a control group of soldiers who did not (n=244,504; 99.1%). Socio-demographic and personal characteristics as well as psychiatric diagnoses were compared. Results The strongest risk factors for suicide attempt were serving less than 12 months (RR=7.09) and a history of unauthorized absence from service (RR=5.68). Moderate risk factors were low socioeconomic status (RR=2.17), psychiatric diagnoses at induction (RR=1.94), non-Jewish religion (RR=1.92), low intellectual rating score (RR=1.84), serving in non-combat unit (RR=1.72) and being born in the former Soviet Union (RR=1.61). A weak association was found between male gender and suicide attempt (RR=1.36). Soldiers who met more frequently with a primary care physician (PCP) had a higher risk for suicide attempt, as opposed to a mental health professional (MHCP), where frequent meetings were found to be a protective factor (P<0.0001). The psychiatric diagnoses associated with a suicide attempt were a cluster B personality disorder (RR=3.00), eating disorders (RR=2.78), mood disorders (RR=2.71) and adjustment disorders (RR=2.26). Mild suicidal behavior constitutes a much larger proportion than among civilians and may have secondary gain thus distorting the suicidal behavior data. Training primary care physicians as gatekeepers and improved monitoring, may reduce the rate of suicide attempts. Copyright © 2015 Elsevier B.V. All rights reserved.

Flowery odor formation revealed by differential expression of monoterpene biosynthetic genes and monoterpene accumulation in rose (Rosa rugosa Thunb.).

PubMed

Feng, Liguo; Chen, Chen; Li, Tinglin; Wang, Meng; Tao, Jun; Zhao, Daqiu; Sheng, Lixia

2014-02-01

Rosa rugosa is an important ornamental and economical plant. In this paper, four genes encoding 1-deoxy-D-xylulose-5-phosphate synthase (DXS), 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), alcohol acyltransferase (AAT) and linalool synthase (LIS) involved in the monoterpene biosynthesis pathways were isolated from R. rugosa 'Tangzi', and the expression patterns of these genes in different flower development stages and different parts of floral organs were determined by real-time quantitative fluorescence PCR. Furthermore, a comprehensive analysis was carried out into the relationship between expression of four monoterpene synthesis genes and accumulation of main volatile monoterpenes and their acetic acid ester derivatives. The results showed that the genes RrDXS, RrDXR and RrLIS showed consistent expressions during the development process for R. rugosa flower from budding to withering stage, the overall expression levels of gene RrDXS and RrLIS were obviously lower as compared with those of gene RrDXR and RrAAT. Although the gene RrDXS, RrDXR, RrAAT and RrLIS were expressed in all parts of R. rugosa floral organs, the expression levels varied significantly. The variations in the constituent and content of volatile monoterpenes including citronellol, geraniol, nerol, linalool, citronellyl acetate, geranyl acetate and neryl acetate at different development stages and parts of floral organs were significantly different. On this basis, we concluded that the gene RrDXR and RrAAT might play a key role in the biosynthesis of volatile monoterpenes in R. rugosa flowers, and the two genes are important candidate genes for the regulation of secondary metabolism for rose aromatic components. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Ventricular Cycle Length Characteristics Estimative of Prolonged RR Interval during Atrial Fibrillation

PubMed Central

CIACCIO, EDWARD J.; BIVIANO, ANGELO B.; GAMBHIR, ALOK; EINSTEIN, ANDREW J.; GARAN, HASAN

2014-01-01

Background When atrial fibrillation (AF) is incessant, imaging during a prolonged ventricular RR interval may improve image quality. It was hypothesized that long RR intervals could be predicted from preceding RR values. Methods From the PhysioNet database, electrocardiogram RR intervals were obtained from 74 persistent AF patients. An RR interval lengthened by at least 250 ms beyond the immediately preceding RR interval (termed T0 and T1, respectively) was considered prolonged. A two-parameter scatterplot was used to predict the occurrence of a prolonged interval T0. The scatterplot parameters were: (1) RR variability (RRv) estimated as the average second derivative from 10 previous pairs of RR differences, T13–T2, and (2) Tm–T1, the difference between Tm, the mean from T13 to T2, and T1. For each patient, scatterplots were constructed using preliminary data from the first hour. The ranges of parameters 1 and 2 were adjusted to maximize the proportion of prolonged RR intervals within range. These constraints were used for prediction of prolonged RR in test data collected during the second hour. Results The mean prolonged event was 1.0 seconds in duration. Actual prolonged events were identified with a mean positive predictive value (PPV) of 80% in the test set. PPV was >80% in 36 of 74 patients. An average of 10.8 prolonged RR intervals per 60 minutes was correctly identified. Conclusions A method was developed to predict prolonged RR intervals using two parameters and prior statistical sampling for each patient. This or similar methodology may help improve cardiac imaging in many longstanding persistent AF patients. PMID:23998759

Cancer in American Indian and Alaska Native young adults (ages 20-44 years): US, 1999-2004.

PubMed

Weir, Hannah K; Jim, Melissa A; Marrett, Loraine D; Fairley, Temeika

2008-09-01

An examination of cancer incidence patterns in American Indians and Alaska Native (AI/AN) young adults may provide insight into their present and future cancer burden. To reduce racial misclassification, incidence data were linked with the Indian Health Service (IHS) patient services database. Age-adjusted cancer incidence rates per 100,000 (AAR) and corresponding rate ratios (RR) for young adults (ages 20-44 years) were compared across IHS regions and for selected cancers within Contract Health Service Delivery Area counties by race (AI/AN vs non-Hispanic whites [NHW]) and sex. The all-sites cancer incidence rate was lower for AI/ANs (AAR of 83.8) than for NHWs (AAR of 111.2) (RR of 0.75) but varied by IHS regions. Among the leading cancers in AI/AN females the risk was elevated for stomach (RR of 3.22), colorectal (RR of 1.30), uterine (RR of 1.61), and kidney (RR of 1.39) cancers and was lower for breast (RR of 0.70) and thyroid (RR of 0.71) cancers. Among AI/AN young adult males the risk was elevated for stomach (RR of 2.62), liver (RR of 1.89), and kidney (RR of 1.59) cancers and lower for testicular germ cell cancer (RR of 0.64) and lymphoma (RR of 0.60). The risk for these and other cancers varied across IHS regions. Many of the cancer patterns that characterize the AI/AN population overall are apparent among young adults. Compared with NHW young adults, the overall cancer burden among AI/AN young adults was lower but varied for selected cancers and across IHS regions. Cancer control and research strategies are needed to address the unique genetic, social, cultural, and lifestyle aspects of AI/AN young adults.

Risk factors for colorectal cancer in subjects with family history of the disease.

PubMed

Fernandez, E; La Vecchia, C; D'Avanzo, B; Negri, E; Franceschi, S

1997-01-01

The relationship between lifestyle factors, past medical conditions, daily meal frequency, diet and the risk of 'familial' colorectal cancer has been analysed using data from a case-control study conducted in northern Italy. A total of 1584 colorectal cancer patients and 2879 control subjects were admitted to a network of hospitals in the Greater Milan area and the Pordenone province. The subjects included for analysis were the 112 cases and the 108 control subjects who reported a family history of colorectal cancer in first-degree relatives. Colorectal cancer cases and control subjects with family history were similarly distributed according to sex, age, marital status, years of schooling and social class. Familial colorectal cancer was associated with meal frequency, medical history of diabetes (relative risk, RR = 4.6) and cholelithiasis (RR = 5.2). Significant positive trends of increasing risk with more frequent consumption were observed for pasta (RR = 2.5, for the highest vs the lowest intake tertile), pastries (RR = 2.4), red meat (RR = 2.9), canned meat (RR = 1.9), cheese (RR = 3.5) and butter (RR = 1.9). Significant inverse associations and trends in risk were observed for consumption of poultry (RR = 0.4), tomatoes (RR = 0.2), peppers (RR = 0.3) and lettuce (RR = 0.3). Significant inverse trends in risk with increasing consumption for beta-carotene and ascorbic acid were observed (RR = 0.5 and 0.4 respectively, highest vs lowest intake tertile). These results suggest that risk factors for subjects with a family history of colorectal cancer in first-degree relatives are not appreciably different from recognized risk factors of the disease in the general population.

Asymmetry of Responsiveness in Client-Centered Therapy

ERIC Educational Resources Information Center

Shapiro, David A.

1977-01-01

Each utterance of a psychotherapy session conducted by Carl Rogers was transcribed on a separate card. Fifteen undergraduate subjects reconstituted client-therapist sequences more accurately than therapist-client sequences. (Author)

Time to ART Initiation among Patients Treated for Rifampicin-Resistant Tuberculosis in Khayelitsha, South Africa: Impact on Mortality and Treatment Success.

PubMed

Daniels, Johnny Flippie; Khogali, Mohammed; Mohr, Erika; Cox, Vivian; Moyo, Sizulu; Edginton, Mary; Hinderaker, Sven Gudmund; Meintjes, Graeme; Hughes, Jennifer; De Azevedo, Virginia; van Cutsem, Gilles; Cox, Helen Suzanne

2015-01-01

Khayelitsha, South Africa, with high burdens of rifampicin-resistant tuberculosis (RR-TB) and HIV co-infection. To describe time to antiretroviral treatment (ART) initiation among HIV-infected RR-TB patients initiating RR-TB treatment and to assess the association between time to ART initiation and treatment outcomes. A retrospective cohort study of patients with RR-TB and HIV co-infection not on ART at RR-TB treatment initiation. Of the 696 RR-TB and HIV-infected patients initiated on RR-TB treatment between 2009 and 2013, 303 (44%) were not on ART when RR-TB treatment was initiated. The median CD4 cell count was 126 cells/mm3. Overall 257 (85%) patients started ART during RR-TB treatment, 33 (11%) within 2 weeks, 152 (50%) between 2-8 weeks and 72 (24%) after 8 weeks. Of the 46 (15%) who never started ART, 10 (21%) died or stopped RR-TB treatment within 4 weeks and 16 (37%) had at least 4 months of RR-TB treatment. Treatment success and mortality during treatment did not vary by time to ART initiation: treatment success was 41%, 43%, and 50% among patients who started ART within 2 weeks, between 2-8 weeks, and after 8 weeks (p = 0.62), while mortality was 21%, 13% and 15% respectively (p = 0.57). Mortality was associated with never receiving ART (adjusted hazard ratio (aHR) 6.0, CI 2.1-18.1), CD4 count ≤100 (aHR 2.1, CI 1.0-4.5), and multidrug-resistant tuberculosis (MDR-TB) with second-line resistance (aHR 2.5, CI 1.1-5.4). Despite wide variation in time to ART initiation among RR-TB patients, no differences in mortality or treatment success were observed. However, a significant proportion of patients did not initiate ART despite receiving >4 months of RR-TB treatment. Programmatic priorities should focus on ensuring all patients with RR-TB/HIV co-infection initiate ART regardless of CD4 count, with special attention for patients with CD4 counts ≤ 100 to initiate ART as soon as possible after RR-TB treatment initiation.

Strategies to improve retention in randomised trials: a Cochrane systematic review and meta-analysis

PubMed Central

Brueton, V C; Tierney, J F; Stenning, S; Meredith, S; Harding, S; Nazareth, I; Rait, G

2014-01-01

Objective To quantify the effect of strategies to improve retention in randomised trials. Design Systematic review and meta-analysis. Data sources Sources searched: MEDLINE, EMBASE, PsycINFO, DARE, CENTRAL, CINAHL, C2-SPECTR, ERIC, PreMEDLINE, Cochrane Methodology Register, Current Controlled Trials metaRegister, WHO trials platform, Society for Clinical Trials (SCT) conference proceedings and a survey of all UK clinical trial research units. Review methods Included trials were randomised evaluations of strategies to improve retention embedded within host randomised trials. The primary outcome was retention of trial participants. Data from trials were pooled using the fixed-effect model. Subgroup analyses were used to explore the heterogeneity and to determine whether there were any differences in effect by the type of strategy. Results 38 retention trials were identified. Six broad types of strategies were evaluated. Strategies that increased postal questionnaire responses were: adding, that is, giving a monetary incentive (RR 1.18; 95% CI 1.09 to 1.28) and higher valued incentives (RR 1.12; 95% CI 1.04 to 1.22). Offering a monetary incentive, that is, an incentive given on receipt of a completed questionnaire, also increased electronic questionnaire response (RR 1.25; 95% CI 1.14 to 1.38). The evidence for shorter questionnaires (RR 1.04; 95% CI 1.00 to 1.08) and questionnaires relevant to the disease/condition (RR 1.07; 95% CI 1.01 to 1.14) is less clear. On the basis of the results of single trials, the following strategies appeared effective at increasing questionnaire response: recorded delivery of questionnaires (RR 2.08; 95% CI 1.11 to 3.87); a ‘package’ of postal communication strategies (RR 1.43; 95% CI 1.22 to 1.67) and an open trial design (RR 1.37; 95% CI 1.16 to 1.63). There is no good evidence that the following strategies impact on trial response/retention: adding a non-monetary incentive (RR=1.00; 95% CI 0.98 to 1.02); offering a non-monetary incentive (RR=0.99; 95% CI 0.95 to 1.03); ‘enhanced’ letters (RR=1.01; 95% CI 0.97 to 1.05); monetary incentives compared with offering prize draw entry (RR=1.04; 95% CI 0.91 to 1.19); priority postal delivery (RR=1.02; 95% CI 0.95 to 1.09); behavioural motivational strategies (RR=1.08; 95% CI 0.93 to 1.24); additional reminders to participants (RR=1.03; 95% CI 0.99 to 1.06) and questionnaire question order (RR=1.00, 0.97 to 1.02). Also based on single trials, these strategies do not appear effective: a telephone survey compared with a monetary incentive plus questionnaire (RR=1.08; 95% CI 0.94 to 1.24); offering a charity donation (RR=1.02, 95% CI 0.78 to 1.32); sending sites reminders (RR=0.96; 95% CI 0.83 to 1.11); sending questionnaires early (RR=1.10; 95% CI 0.96 to 1.26); longer and clearer questionnaires (RR=1.01, 0.95 to 1.07) and participant case management by trial assistants (RR=1.00; 95% CI 0.97 to 1.04). Conclusions Most of the trials evaluated questionnaire response rather than ways to improve participants return to site for follow-up. Monetary incentives and offers of monetary incentives increase postal and electronic questionnaire response. Some strategies need further evaluation. Application of these results would depend on trial context and follow-up procedures. PMID:24496696

Healthier central England or North–South divide? Analysis of national survey data on smoking and high-risk drinking

PubMed Central

Beard, Emma; Brown, Jamie; West, Robert; Angus, Colin; Kaner, Eileen; Michie, Susan

2017-01-01

Objectives This paper compares patterns of smoking and high-risk alcohol use across regions in England, and assesses the impact on these of adjusting for sociodemographic characteristics. Design Population survey of 53 922 adults in England aged 16+ taking part in the Alcohol and Smoking Toolkit Studies. Measures Participants answered questions regarding their socioeconomic status (SES), gender, age, ethnicity, Government Office Region, smoking status and completed the Alcohol Use Disorders Identification Test (AUDIT). High-risk drinkers were defined as those with a score of 8 or more (7 or more for women) on the AUDIT. Results In unadjusted analyses, relative to the South West, those in the North of England were more likely to smoke, while those from the East of England, South East and London were less likely. After adjustment for sociodemographics, smoking prevalence was no higher in North East (RR 0.97, p>0.05), North West (RR 0.98, p>0.05) or Yorkshire and the Humber (RR 1.03, p>0.05) but was less common in the East and West Midlands (RR 0.86, p<0.001; RR 0.91, p<0.05), East of England (RR 0.86, p<0.001), South East (RR 0.92, p<0.05) and London (RR 0.85, p<0.001). High-risk drinking was more common in the North but was less common in the Midlands, London and East of England. Adjustment for sociodemographics had little effect. There was a higher prevalence in the North East (RR 1.67, p<0.001), North West (RR 1.42, p<0.001) and Yorkshire and the Humber (RR 1.35, p<0.001); lower prevalence in the East Midlands (RR 0.69, p<0.001), West Midlands (RR 0.77, p<0.001), East of England (RR 0.72, p<0.001) and London (RR 0.71, p<0.001); and a similar prevalence in the South East (RR 1.10, p>0.05) Conclusions In adjusted analyses, smoking and high-risk drinking appear less common in ‘central England’ than in the rest of the country. Regional differences in smoking, but not those in high-risk drinking, appear to be explained to some extent by sociodemographic disparities. PMID:28249851

Episiotomy and its relationship to various clinical variables that influence its performance

PubMed Central

Ballesteros-Meseguer, Carmen; Carrillo-García, César; Meseguer-de-Pedro, Mariano; Canteras-Jordana, Manuel; Martínez-Roche, Mª Emilia

2016-01-01

Objective: to understand the episiotomy rate and its relationship with various clinical variables. Method: a descriptive, cross-sectional, analytic study of 12,093 births in a tertiary hospital. Variables: Parity, gestational age, start of labor, use of epidural analgesia, oxytocin usage, position during fetal explusion, weight of neonate, and completion of birth. The analysis was performed with SPSS 19.0. Results: the global percentage of episiotomies was 50%. The clinical variables that presented a significant association were primiparity (RR=2.98), gestational age >41 weeks (RR=1.2), augmented or induced labor (RR=1.33), epidural analgesia use (RR=1,95), oxytocin use (RR=1.58), lithotomy position during fetal expulsion (RR=6.4), and instrumentation (RR=1.84). Furthermore, maternal age ≥35 years (RR=0.85) and neonatal weight <2500 g (RR=0.8) were associated with a lower incidence of episiotomy. Conclusions: episiotomy is dependent on obstetric interventions performed during labor. If we wish to reduce the episiotomy rate, it will be necessary to bear in mind these risk factors when establishing policies for reducing this procedure. PMID:27224064

Manual perineal support at the time of childbirth: a systematic review and meta-analysis.

PubMed

Bulchandani, S; Watts, E; Sucharitha, A; Yates, D; Ismail, K M

2015-08-01

Genital tract trauma is common with vaginal births and is associated with significant morbidity, particularly with obstetric anal sphincter injuries (OASIS). Debate continues regarding the effectiveness of perineal support during childbirth in reducing the risk of trauma. This review aimed to assess the effect of routine 'hands on'/manual perineal support (MPS) during childbirth, versus ad hoc/no perineal support ('hands off/poised'), on the risk and degree of perineal trauma. This review is registered on PROSPERO (http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014007058). We searched the CENTRAL, Embase, Medline, CINAHL, and OVIDs midwifery and infant care databases (from inception to December 2014). Published randomised controlled trials (RCTs) and non-randomised studies (NRSs) evaluating any 'hands on' perineal support technique during childbirth. Two reviewers independently assessed trials for inclusion, data extraction, and methodological quality. Discrepancies were resolved by discussion with a third reviewer. We included five RCTs and seven NRSs in the review. Meta-analysis of RCTs did not demonstrate a statistically significant protective effect of MPS on the risk of OASIS (three studies, 6647 women; relative risk, RR 1.03; 95% confidence interval, 95% CI 0.32-3.36; statistical test for heterogeneity I(2) = 71%). Meta-analysis of NRSs showed a significant reduction in the risk of OASIS with MPS (three studies, 74,744 women; RR 0.45; 95% CI 0.40-0.50; I(2) = 32%). Current evidence is insufficient to drive change in practice. An adequately powered randomised trial with an efficient design to evaluate the complex interventions adopted as part of MPS policies, ensuring controlled childbirth, is urgently needed. © 2015 Royal College of Obstetricians and Gynaecologists.

Spectroscopic, Computational and Kinetic Studies of the μ4-Sulfide Bridged Tetranuclear CuZ Cluster in N2O Reductase: pH Effect on the Edge Ligand and its Contribution to Reactivity

PubMed Central

Ghosh, Somdatta; Gorelsky, Serge I.; George, Serena DeBeer; Chan, Jeannine M.; Cabrito, Inês; Dooley, David M.; Moura, José J. G.; Moura, Isabel; Solomon, Edward I.

2008-01-01

A combination of spectroscopy and DFT calculations has been used to evaluate the pH effect at the CuZ site in Pseudomonas nautica (Pn) N2OR and Achromobacter cycloclastes (Ac) N2OR and its relevance to catalysis. Absorption, MCD, EPR with sulfur K-edge XAS spectra of the enzymes at high and low pH show minor changes. However, resonance Raman (rR) spectroscopy of PnN2OR at high pH shows that the 415 cm−1 Cu-S vibration (observed at low pH) shifts to higher frequency, loses intensity and obtains a 9 cm−1 18O shift, implying significant Cu-O character, demonstrating the presence of a OH− ligand at the CuICuIV edge. From DFT calculations both protonation of the OH− to H2O or the μ4-S2− to μ4-SH− would produce large spectral changes which are not observed. Alternatively, DFT calculations including a lysine residue at an H-bonding distance from the CuICuIV edge ligand show that the position of the OH− ligand depends on the protonation state of the lysine. This would change the coupling of the Cu-(OH) stretch with the Cu-S stretch, as observed in the rR spectrum. Thus the observed pH effect (pKa ~9.2) likely reflects protonation equilibrium of the lysine residue which would both raise E0 and provide a proton for lowering the barrier for the N-O cleavage and for reduction of the [Cu4S(im)7OH]2+ to the fully reduced 4CuI active form for turnover. PMID:17352474

The Treatment of Non-Fluent Utterance--A Behavioral Approach

ERIC Educational Resources Information Center

Wohl, Maud T.

1970-01-01

Indicates that a behavioral approach, utilizing an electronic metronome in speech and motor activities, is highly effective in reducing the occurrence of stammering in children and adults. Bibliography. (RW)

Exploring the influence of cultural orientations on assessment of communication behaviours during patient-practitioner interactions.

PubMed

Wilby, Kyle J; Govaerts, Marjan J B; Austin, Zubin; Dolmans, Diana H J M

2017-03-21

Research has shown that patients' and practitioners' cultural orientations affect communication behaviors and interpretations in cross-cultural patient-practitioner interactions. Little is known about the effect of cultural orientations on assessment of communication behaviors in cross-cultural educational settings. The purpose of this study is to explore cultural orientation as a potential source of assessor idiosyncrasy or between-assessor variability in assessment of communication skills. More specifically, we explored if and how (expert) assessors' valuing of communication behaviours aligned with their cultural orientations (power-distance, masculinity-femininity, uncertainty avoidance, and individualism-collectivism). Twenty-five pharmacist-assessors watched 3 videotaped scenarios (patient-pharmacist interactions) and ranked each on a 5-point global rating scale. Videotaped scenarios demonstrated combinations of well-portrayed and borderline examples of instrumental and affective communication behaviours. We used stimulated recall and verbal protocol analysis to investigate assessors' interpretations and evaluations of communication behaviours. Uttered assessments of communication behaviours were coded as instrumental (task-oriented) or affective (socioemotional) and either positive or negative. Cultural orientations were measured using the Individual Cultural Values Scale. Correlations between cultural orientations and global scores, and frequencies of positive, negative, and total utterances of instrumental and affective behaviours were determined. Correlations were found to be scenario specific. In videos with poor or good performance, no differences were found across cultural orientations. When borderline performance was demonstrated, high power-distance and masculinity were significantly associated with higher global ratings (r = .445, and .537 respectively, p < 0.05) as well as with fewer negative utterances regarding instrumental (task focused) behaviours (r = -.533 and - .529, respectively). Higher masculinity scores were furthermore associated with positive utterances of affective (socioemotional) behaviours (r = .441). Our findings thus confirm cultural orientation as a source of assessor idiosyncrasy and meaningful variations in interpretation of communication behaviours. Interestingly, expert assessors generally agreed on scenarios of good or poor performances but borderline performance was influenced by cultural orientation. Contrary to current practices of assessor and assessment instrument standardization, findings support the use of multiple assessors for patient-practitioner interactions and development of qualitative assessment tools to capture these varying, yet valid, interpretations of performance.

76 FR 67454 - Agency Information Collection Request; 30-Day Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-01

... revising the collection to include changes adopted by the cross-agency R&R working group. This working... Assistance (Cover); R&R Personal Data; R&R Senior/Key Person Profile; R&R Senior/Key Person Profile (Expanded...

Large subunit of the ribonucleotide reductase gene is a virulent factor and plays a critical role in Marek's disease virus pathogenesis

USDA-ARS?s Scientific Manuscript database

Marek’s disease virus (MDV) encodes a ribonucleotide reductase (RR) gene consisting of two subunits UL39 (RR1) and UL40 (RR2). Both RR1 and RR2 form an active holoenzyme and are necessary for enzyme activity. This gene was indentified by monoclonal antibody T81 in a gt11 MDV expression library and f...

Multiband Fourier Analysis and Interstellar Reddening of the Variable Stars in the Globular Cluster NGC 6402 (M14)

NASA Astrophysics Data System (ADS)

Weinschenk, Sedrick; Murphy, Brian; Villiger, Nathan J.

2018-01-01

We present a detailed study of the variable stars in the globular cluster NGC 6402 (M14). Approximately 1500 B and V band images were collected from July 2016 to August 2017 using the SARA Consortium Jacobus Kaptyen 1-meter telescope located in the Canary Islands. Using difference image analysis, we were able to identify 145 probable variable stars, confirming the 133 previously known variables and adding 12 new variables. The variables consisted of 117 RR Lyrae stars, 18 long period variables, 2 eclipsing variables, 6 Cepheid variables, and 2 SX Phoenix variables. Of the RR Lyrae variables 55 were of fundamental mode RR0 stars, of which 18 exhibited the Blazhko effect, 57 were of 1st overtone RR1, of which 7 appear to exhibit the Blazhko effect, 1 2nd overtone RR2, and 2 double mode variables. We found an average period of 0.59016 days for RR0 stars and 0.30294 days for RR1 stars. Using the multiband light curves of both the RR0 and RR1 variables we found an average E(B-V) of 0.604 with a scatter of 0.15 magnitudes. Using Fourier decomposition of the RR Lyrae light curves we also determined the metallicity and distance of the NGC 6402.

8 CFR 313.2 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... in the United States of a totalitarian dictatorship; or (c) Is or has been a member of or affiliated... totalitarian dictatorship, either through its own utterance or through any written or printed matter published...

8 CFR 313.2 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... in the United States of a totalitarian dictatorship; or (c) Is or has been a member of or affiliated... totalitarian dictatorship, either through its own utterance or through any written or printed matter published...

Effect of thalidomide on the expression of TNF-alpha m-RNA and synthesis of TNF-alpha in cells from leprosy patients with reversal reaction.

PubMed

Tadesse, Azeb; Abebe, Markos; Bizuneh, Elizabeth; Mulugeta, Wondwossen; Aseffa, Abraham; Shannon, E J

2006-01-01

Hypersensitivity reactions called reversal reaction (RR) and erythema nodosum leprosum (ENL) occur in leprosy. They are characterized by an increase in tumor necrosis factor-alpha (TNF-alpha). Thalidomide is an effective treatment for ENL but not RR. Its effectiveness in ENL is attributed to inhibition of TNF-alpha, and this does not explain its failure to treat RR. We assessed thalidomide's effect on TNF-alpha in RR. Mononuclear cells from RR and non-RR patients and healthy individuals were treated with thalidomide and M.leprae (AFB), a cytosol fraction of M. leprae or Dharmendra lepromin. Thalidomide suppressed TNF-alpha, but when some RR patients' cells were stimulated with AFB, it enhanced TNF-alpha.

Geminal difunctionalization of α-diazo arylmethylphosphonates: synthesis of fluorinated phosphonates.

PubMed

Zhou, Yujing; Zhang, Yan; Wang, Jianbo

2016-11-08

A general approach towards diverse fluorinated phosphonates via geminal difunctionalization reactions of α-diazo arylmethylphosphonates is described. The diazo functionality (RR'C[double bond, length as m-dash]N 2 ) is successfully converted to RR'CF 2 , RR'CHF, RR'CFBr or RR'CFNR'' 2 groups by employing different fluorination reagents. A variety of fluorinated organophosphorus compounds were readily accessed in good to excellent yields from a common type of precursor.

Water and nitrogen management effects on water and nitrogen fluxes in Florida Flatwoods.

PubMed

Hendricks, Gregory S; Shukla, Sanjay

2011-01-01

The effects of water and fertilizer best management practices (BMPs) have not been quantified for groundwater nitrogen (N) beneath seepage irrigated vegetable fields with shallow water table environments. This effect was evaluated by a 3-yr study conducted in the Flatwoods of south Florida for watermelon ( cv. Mardi Gras and Tri-X 313) and tomato ( cv. BHN 586) using three treatments of water and inorganic fertilizer N (N) rates: (i) high fertilizer and water rates with seepage irrigation (HR), (ii) recommended fertilizer and water rates (BMP) with seepage irrigation (RR); and (iii) RR with subsurface drip irrigation (RR-SD). These treatments were implemented on six hydraulically isolated plots. The N rate treatments for high (HR) and recommended (RR and RR-SD) were based on a grower survey and BMP recommendations, respectively. Water applied, water table depth, and soil moisture content were regularly monitored for each treatment. Plant, soil, and groundwater N sampling and analyses were conducted for each season of the 3-yr study. The average water applied in HR (187 cm) was greater than RR (172 cm) and RR-SD (94 cm). Soil N maintained in crop beds for HR was significantly higher than RR and RR-SD. Soil solution analyses showed that N leached beneath HR (112 mg L) was greater ( = 0.053) than RR (76 mg L) and RR-SD (88 mg L). Shallow groundwater concentrations of dissolved inorganic nitrogen (NH-N + NO-N) were higher ( = 0.02) in HR (37 mg L) compared with RR (15 mg L) and RR-SD (19 mg L). Decreased N and water table levels can improve groundwater quality by reducing N leachate in shallow water table environments with seepage irrigated vegetable production systems. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Echolalia and Comprehension in Autistic Children.

ERIC Educational Resources Information Center

Roberts, Jacqueline M. A.

1989-01-01

The study with 10 autistic children (ages 4-17) found that those children with poor receptive language skills produced significantly more echolalic utterances than those children whose receptive skills were more age-appropriate. (Author/DB)

"Space flight is utter bilge"

NASA Astrophysics Data System (ADS)

Yeomans, Donald

2004-01-01

Despite skepticism and ridicule from scientists and the public alike, a small handful of dreamers kept faith in their vision of space flight and planned for the day when humanity would break loose from Earth.

Intelligibility assessment in developmental phonological disorders: accuracy of caregiver gloss.

PubMed

Kwiatkowski, J; Shriberg, L D

1992-10-01

Fifteen caregivers each glossed a simultaneously videotaped and audiotaped sample of their child with speech delay engaged in conversation with a clinician. One of the authors generated a reference gloss for each sample, aided by (a) prior knowledge of the child's speech-language status and error patterns, (b) glosses from the child's clinician and the child's caregiver, (c) unlimited replays of the taped sample, and (d) the information gained from completing a narrow phonetic transcription of the sample. Caregivers glossed an average of 78% of the utterances and 81% of the words. A comparison of their glosses to the reference glosses suggested that they accurately understood an average of 58% of the utterances and 73% of the words. Discussion considers the implications of such findings for methodological and theoretical issues underlying children's moment-to-moment intelligibility breakdowns during speech-language processing.

DREAM: Classification scheme for dialog acts in clinical research query mediation.

PubMed

Hoxha, Julia; Chandar, Praveen; He, Zhe; Cimino, James; Hanauer, David; Weng, Chunhua

2016-02-01

Clinical data access involves complex but opaque communication between medical researchers and query analysts. Understanding such communication is indispensable for designing intelligent human-machine dialog systems that automate query formulation. This study investigates email communication and proposes a novel scheme for classifying dialog acts in clinical research query mediation. We analyzed 315 email messages exchanged in the communication for 20 data requests obtained from three institutions. The messages were segmented into 1333 utterance units. Through a rigorous process, we developed a classification scheme and applied it for dialog act annotation of the extracted utterances. Evaluation results with high inter-annotator agreement demonstrate the reliability of this scheme. This dataset is used to contribute preliminary understanding of dialog acts distribution and conversation flow in this dialog space. Copyright © 2015 Elsevier Inc. All rights reserved.

Vocal Tones Influence Young Children’s Responses to Prohibitions

PubMed Central

Dahl, Audun; Tran, Amy Q.

2016-01-01

Vocal reactions to child transgressions convey information about the nature of those transgressions. The present research investigated children’s ability to make use of such vocal reactions. Study 1 investigated infants’ compliance with a vocal prohibition telling them to stay away from a toy. Compared to younger infants, older infants showed greater compliance with prohibitions elicited by moral (interpersonal harm) transgressions, but not with prohibitions elicited by pragmatic (inconvenience) transgressions. Study 2 investigated preschoolers’ use of firm-stern vocalizations (associated with moral transgressions) and positive vocalizations (associated with pragmatic transgressions). Most children guessed that the firm-stern vocalizations were uttered in response to a moral transgression and the positive vocalization were uttered in response to a pragmatic transgression. These two studies suggest that children use vocal tones, along with other experiences, to guide their compliance with and interpretation of prohibitions. PMID:27518810

Naturalistic and Experimental Analyses of Word Frequency and Neighborhood Density Effects in Slips of the Ear*

PubMed Central

Vitevitch, Michael S.

2008-01-01

A comparison of the lexical characteristics of 88 auditory misperceptions (i.e., slips of the ear) showed no difference in word-frequency, neighborhood density, and neighborhood frequency between the actual and the perceived utterances. Another comparison of slip of the ear tokens (i.e., actual and perceived utterances) and words in general (i.e., randomly selected from the lexicon) showed that slip of the ear tokens had denser neighborhoods and higher neighborhood frequency than words in general, as predicted from laboratory studies. Contrary to prediction, slip of the ear tokens were higher in frequency of occurrence than words in general. Additional laboratory-based investigations examined the possible source of the contradictory word frequency finding, highlighting the importance of using naturalistic and experimental data to develop models of spoken language processing. PMID:12866911

"That's really clever!" Ironic hyperbole understanding in children.

PubMed

Aguert, Marc; LE Vallois, Coralie; Martel, Karine; Laval, Virginie

2018-01-01

Hyperbole supports irony comprehension in adults by heightening the contrast between what is said and the actual situation. Because young children do not perceive the communication situation as a whole, but rather give precedence to either the utterance or the context, we predicted that hyperbole would reduce irony comprehension in six-year-olds (n = 40) by overemphasizing what was said. By contrast, ten-year-olds (n = 40) would benefit from hyperbole in the way that adults do, as they would perceive the utterance and context as a whole, highlighted by the speaker's ironic intent. Short animated cartoons featuring ironic criticisms were shown to participants. We assessed comprehension of the speaker's belief and speaker's intent. Results supported our predictions. The development of mentalization during school years and its impact on the development of irony comprehension is discussed.

Factors Affecting Two Types of Memory Specificity: Particularization of Episodes and Details.

PubMed

Willén, Rebecca M; Granhag, Pär Anders; Strömwall, Leif A

2016-01-01

Memory for repeated events is relevant to legal investigations about repeated occurrences. We investigated how two measures of specificity (number of events referred to and amount of detail reported about the events) were influenced by interviewees' age, number of experienced events, interviewer, perceived unpleasantness, and memory rehearsal. Transcribed narratives consisting of over 40.000 utterances from 95 dental patients, and the corresponding dental records, were studied. Amount of detail was measured by categorizing the utterances as generic, specific, or specific-extended. We found that the two measures were affected differently by all five factors. For instance, number of experienced events positively influenced number of referred events but had no effect on amount of detail provided about the events. We make suggestions for future research and encourage reanalysis of the present data set and reuse of the material.

First insights into the vocal repertoire of infant and juvenile Southern white rhinoceros

PubMed Central

Boeer, Michael; Scheumann, Marina

2018-01-01

Describing vocal repertoires represents an essential step towards gaining an overview about the complexity of acoustic communication in a given species. The analysis of infant vocalisations is essential for understanding the development and usage of species-specific vocalisations, but is often underrepresented, especially in species with long inter-birth intervals such as the white rhinoceros. Thus, this study aimed for the first time to characterise the infant and juvenile vocal repertoire of the Southern white rhinoceros and to relate these findings to the adult vocal repertoire. The behaviour of seven mother-reared white rhinoceros calves (two males, five females) and one hand-reared calf (male), ranging from one month to four years, was simultaneously audio and video-taped at three zoos. Normally reared infants and juveniles uttered four discriminable call types (Whine, Snort, Threat, and Pant) that were produced in different behavioural contexts. All call types were also uttered by the hand-reared calf. Call rates of Whines, but not of the other call types, decreased with age. These findings provide the first evidence that infant and juvenile rhinoceros utter specific call types in distinct contexts, even if they grow up with limited social interaction with conspecifics. By comparing our findings with the current literature on vocalisations of adult white rhinoceros and other solitary rhinoceros species, we discuss to which extent differences in the social lifestyle across species affect acoustic communication in mammals. PMID:29513670

Frontal brain activation in premature infants' response to auditory stimuli in neonatal intensive care unit.

PubMed

Saito, Yuri; Fukuhara, Rie; Aoyama, Shiori; Toshima, Tamotsu

2009-07-01

The present study was focusing on the very few contacts with the mother's voice that NICU infants have in the womb as well as after birth, we examined whether they can discriminate between their mothers' utterances and those of female nurses in terms of the emotional bonding that is facilitated by prosodic utterances. Twenty-six premature infants were included in this study, and their cerebral blood flows were measured by near-infrared spectroscopy. They were exposed to auditory stimuli in the form of utterances made by their mothers and female nurses. A two (stimulus: mother and nurse) x two (recording site: right frontal area and left frontal area) analysis of variance (ANOVA) for these relative oxy-Hb values was conducted. The ANOVA showed a significant interaction between stimulus and recording site. The mother's and the nurse's voices were activated in the same way in the left frontal area, but showed different reactions in the right frontal area. We presume that the nurse's voice might become associated with pain and stress for premature infants. Our results showed that the premature infants reacted differently to the different voice stimuli. Therefore, we presume that both mothers' and nurses' voices represent positive stimuli for premature infants because both activate the frontal brain. Accordingly, we cannot explain our results only in terms of the state-dependent marker for infantile individual differences, but must also address the stressful trigger of nurses' voices for NICU infants.

The perception of sentence stress in cochlear implant recipients.

PubMed

Meister, Hartmut; Landwehr, Markus; Pyschny, Verena; Wagner, Petra; Walger, Martin

2011-01-01

Sentence stress is a vital attribute of speech since it indicates the importance of specific words within an utterance. Basic acoustic correlates of stress are syllable duration, intensity, and fundamental frequency (F0). Objectives of the study were to determine cochlear implant (CI) users' perception of the acoustic correlates and to uncover which cues are used for stress identification. Several experiments addressed the discrimination of changes in syllable duration, intensity, and F0 as well as stress identification based on these cues. Moreover, the discrimination of combined cues and identification of stress in conversational speech was examined. Both natural utterances and artificial manipulations of the acoustic cues were used as stimuli. Discrimination of syllable duration did not differ significantly between CI recipients and a control group of normal-hearing listeners. In contrast, CI users performed significantly worse on tasks of discrimination and stress identification based on F0 as well as on intensity. Results from these measurements were significantly correlated with the ability to identify stress in conversational speech. Discrimination performance for covarying F0 and intensity changes was more strongly correlated to identification performance than was found for discrimination of either F0 or intensity alone. Syllable duration was not related to stress identification in natural utterances. The outcome emphasizes the importance of both F0 and intensity for CI users' identification of sentence-based stress. Both cues were used separately for stress perception, but combining the cues provided extra benefit for most of the subjects.

Quantifying repetitive speech in autism spectrum disorders and language impairment.

PubMed

van Santen, Jan P H; Sproat, Richard W; Hill, Alison Presmanes

2013-10-01

We report on an automatic technique for quantifying two types of repetitive speech: repetitions of what the child says him/herself (self-repeats) and of what is uttered by an interlocutor (echolalia). We apply this technique to a sample of 111 children between the ages of four and eight: 42 typically developing children (TD), 19 children with specific language impairment (SLI), 25 children with autism spectrum disorders (ASD) plus language impairment (ALI), and 25 children with ASD with normal, non-impaired language (ALN). The results indicate robust differences in echolalia between the TD and ASD groups as a whole (ALN + ALI), and between TD and ALN children. There were no significant differences between ALI and SLI children for echolalia or self-repetitions. The results confirm previous findings that children with ASD repeat the language of others more than other populations of children. On the other hand, self-repetition does not appear to be significantly more frequent in ASD, nor does it matter whether the child's echolalia occurred within one (immediate) or two turns (near-immediate) of the adult's original utterance. Furthermore, non-significant differences between ALN and SLI, between TD and SLI, and between ALI and TD are suggestive that echolalia may not be specific to ALN or to ASD in general. One important innovation of this work is an objective fully automatic technique for assessing the amount of repetition in a transcript of a child's utterances. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.

Quantifying Repetitive Speech in Autism Spectrum Disorders and Language Impairment

PubMed Central

van Santen, Jan P. H.; Sproat, Richard W.; Hill, Alison Presmanes

2013-01-01

We report on an automatic technique for quantifying two types of repetitive speech: repetitions of what the child says him/herself (self-repeats) and of what is uttered by an interlocutor (echolalia). We apply this technique to a sample of 111 children between the ages of four and eight: 42 typically developing children (TD), 19 children with specific language impairment (SLI), 25 children with autism spectrum disorders (ASD) plus language impairment (ALI), and 25 children with ASD with normal, non-impaired language (ALN). The results indicate robust differences in echolalia between the TD and ASD groups as a whole (ALN + ALI), and between TD and ALN children. There were no significant differences between ALI and SLI children for echolalia or self-repetitions. The results confirm previous findings that children with ASD repeat the language of others more than other populations of children. On the other hand, self-repetition does not appear to be significantly more frequent in ASD, nor does it matter whether the child’s echolalia occurred within one (immediate) or two turns (near-immediate) of the adult’s original utterance. Furthermore, non-significant differences between ALN and SLI, between TD and SLI, and between ALI and TD are suggestive that echolalia may not be specific to ALN or to ASD in general. One important innovation of this work is an objective fully automatic technique for assessing the amount of repetition in a transcript of a child’s utterances. PMID:23661504

Deep bottleneck features for spoken language identification.

PubMed

Jiang, Bing; Song, Yan; Wei, Si; Liu, Jun-Hua; McLoughlin, Ian Vince; Dai, Li-Rong

2014-01-01

A key problem in spoken language identification (LID) is to design effective representations which are specific to language information. For example, in recent years, representations based on both phonotactic and acoustic features have proven their effectiveness for LID. Although advances in machine learning have led to significant improvements, LID performance is still lacking, especially for short duration speech utterances. With the hypothesis that language information is weak and represented only latently in speech, and is largely dependent on the statistical properties of the speech content, existing representations may be insufficient. Furthermore they may be susceptible to the variations caused by different speakers, specific content of the speech segments, and background noise. To address this, we propose using Deep Bottleneck Features (DBF) for spoken LID, motivated by the success of Deep Neural Networks (DNN) in speech recognition. We show that DBFs can form a low-dimensional compact representation of the original inputs with a powerful descriptive and discriminative capability. To evaluate the effectiveness of this, we design two acoustic models, termed DBF-TV and parallel DBF-TV (PDBF-TV), using a DBF based i-vector representation for each speech utterance. Results on NIST language recognition evaluation 2009 (LRE09) show significant improvements over state-of-the-art systems. By fusing the output of phonotactic and acoustic approaches, we achieve an EER of 1.08%, 1.89% and 7.01% for 30 s, 10 s and 3 s test utterances respectively. Furthermore, various DBF configurations have been extensively evaluated, and an optimal system proposed.

Distributional Language Learning: Mechanisms and Models of ategory Formation.

PubMed

Aslin, Richard N; Newport, Elissa L

2014-09-01

In the past 15 years, a substantial body of evidence has confirmed that a powerful distributional learning mechanism is present in infants, children, adults and (at least to some degree) in nonhuman animals as well. The present article briefly reviews this literature and then examines some of the fundamental questions that must be addressed for any distributional learning mechanism to operate effectively within the linguistic domain. In particular, how does a naive learner determine the number of categories that are present in a corpus of linguistic input and what distributional cues enable the learner to assign individual lexical items to those categories? Contrary to the hypothesis that distributional learning and category (or rule) learning are separate mechanisms, the present article argues that these two seemingly different processes---acquiring specific structure from linguistic input and generalizing beyond that input to novel exemplars---actually represent a single mechanism. Evidence in support of this single-mechanism hypothesis comes from a series of artificial grammar-learning studies that not only demonstrate that adults can learn grammatical categories from distributional information alone, but that the specific patterning of distributional information among attested utterances in the learning corpus enables adults to generalize to novel utterances or to restrict generalization when unattested utterances are consistently absent from the learning corpus. Finally, a computational model of distributional learning that accounts for the presence or absence of generalization is reviewed and the implications of this model for linguistic-category learning are summarized.

Without his shirt off he saved the child from almost drowning: interpreting an uncertain input

PubMed Central

Frazier, Lyn; Clifton, Charles

2014-01-01

Unedited speech and writing often contains errors, e.g., the blending of alternative ways of expressing a message. As a result comprehenders are faced with decisions about what the speaker may have intended, which may not be the same as the grammatically-licensed compositional interpretation of what was said. Two experiments investigated the comprehension of inputs that may have resulted from blending two syntactic forms. The results of the experiments suggest that readers and listeners tend to repair such utterances, restoring them to the presumed intended structure, and they assign the interpretation of the corrected utterance. Utterances that are repaired are expected to also be acceptable when they are easy to diagnose/repair and they are “familiar”, i.e., they correspond to natural speech errors. The results of the experiments established a continuum ranging from outright linguistic illusions with no indication that listeners and readers detected the error (the inclusion of almost in A passerby rescued a child from almost being run over by a bus.), to a majority of unblended interpretations for doubled quantifier sentences (Many students often turn in their assignments late) to only a third undoubled implicit negation (I just like the way the president looks without his shirt off.) The repair or speech error reversal account offered here is contrasted with the noisy channel approach (Gibson et al., 2013) and the good enough processing approach (Ferreiera et al., 2002). PMID:25984551

Impact of changing US cigarette smoking patterns on incident cancer: risks of 20 smoking-related cancers among the women and men of the NIH-AARP cohort

PubMed Central

Freedman, Neal D; Abnet, Christian C; Caporaso, Neil E; Fraumeni, Joseph F; Murphy, Gwen; Hartge, Patricia; Hollenbeck, Albert R; Park, Yikyung; Shiels, Meredith S; Silverman, Debra T

2016-01-01

Abstract Background: Historically, US women started smoking at a later age than men and had lower relative risks for smoking-related cancers. However, more recent birth cohorts of women and men have similar smoking histories and have now reached the high-risk age for cancer. The impact of these changes on cancer incidence has not been systematically examined. Methods: Relative risks (RR), 95% confidence intervals (CI) and attributable fractions were calculated for cigarette smoking and incidence of 20 smoking-related cancers in 186 057 women and 266 074 men of the National Institutes of Health-AARP cohort, aged 50 to 71 years in 1995 and followed for 11 years. Results: In the cohort, which included participants born between 1924 and 1945, most women and men started smoking as teenagers. RRs for current vs never smoking were similar in women and men for the following cancers: lung squamous-cell (RR women: 121.4, 95% CI: 57.3–257.4; RR men:114.6, 95% CI: 61.2–214.4), lung adenocarcinoma (RR women: 11.7, 95% CI: 9.8–14.0; RR men: 15.6, 95% CI: 12.5–19.6), laryngeal (RR women: 37.0, 95% CI: 14.9–92.3; RR men: 13.8, 95% CI: 9.3–20.2), oral cavity-pharyngeal (RR women:4.4, 95% CI: 3.3–6.0; RR men: 3.8, 95% CI: 3.0–4.7), oesophageal squamous cell (RR women: 7.3, 95% CI: 3.5–15.5; RR men: 6.2, 95% CI: 2.8–13.7), bladder (RR women: 4.7, 95% CI: 3.7–5.8; RR men: 4.0, 95% CI: 3.5–4.5), colon (RR women: 1.3, 95% CI: 1.2–1.5; RR men: 1.3, 95% CI: 1.1–1.4), and at other sites, with similar attributable fractions. Conclusions: RRs for current smoking and incidence of many smoking-related cancers are now similar in US women and men, likely reflecting converging smoking patterns. PMID:26411408

Healthier central England or North-South divide? Analysis of national survey data on smoking and high-risk drinking.

PubMed

Beard, Emma; Brown, Jamie; West, Robert; Angus, Colin; Kaner, Eileen; Michie, Susan

2017-03-01

This paper compares patterns of smoking and high-risk alcohol use across regions in England, and assesses the impact on these of adjusting for sociodemographic characteristics. Population survey of 53 922 adults in England aged 16+ taking part in the Alcohol and Smoking Toolkit Studies. Participants answered questions regarding their socioeconomic status (SES), gender, age, ethnicity, Government Office Region, smoking status and completed the Alcohol Use Disorders Identification Test (AUDIT). High-risk drinkers were defined as those with a score of 8 or more (7 or more for women) on the AUDIT. In unadjusted analyses, relative to the South West, those in the North of England were more likely to smoke, while those from the East of England, South East and London were less likely. After adjustment for sociodemographics, smoking prevalence was no higher in North East (RR 0.97, p>0.05), North West (RR 0.98, p>0.05) or Yorkshire and the Humber (RR 1.03, p>0.05) but was less common in the East and West Midlands (RR 0.86, p<0.001; RR 0.91, p<0.05), East of England (RR 0.86, p<0.001), South East (RR 0.92, p<0.05) and London (RR 0.85, p<0.001). High-risk drinking was more common in the North but was less common in the Midlands, London and East of England. Adjustment for sociodemographics had little effect. There was a higher prevalence in the North East (RR 1.67, p<0.001), North West (RR 1.42, p<0.001) and Yorkshire and the Humber (RR 1.35, p<0.001); lower prevalence in the East Midlands (RR 0.69, p<0.001), West Midlands (RR 0.77, p<0.001), East of England (RR 0.72, p<0.001) and London (RR 0.71, p<0.001); and a similar prevalence in the South East (RR 1.10, p>0.05) CONCLUSIONS: In adjusted analyses, smoking and high-risk drinking appear less common in 'central England' than in the rest of the country. Regional differences in smoking, but not those in high-risk drinking, appear to be explained to some extent by sociodemographic disparities. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Carboxylic Acids as Indicators of Parent Body Conditions

NASA Technical Reports Server (NTRS)

Lerner N. R.; Chang, Sherwood (Technical Monitor)

1995-01-01

Alpha-hydroxy and alpha-amino carboxylic acids found on the Murchison meteorite are deuterium enriched. It is postulated that they arose from a common interstellar scurce: the reaction of carbonyl compounds in an aqueous mixture containing HCN and NH3. Carbonyl compounds react with HCN to form alpha-hydroxy nitriles, RR'CO + HCN right and left arrow RR'C(OH)CN. If ammonia is also present, the alpha-hydroxy nitriles will exist in equilibrium with the alpha-amino nitriles, RR'C(OH)CN + NH3 right and left arrow - RRCNH2CN + H2O. Both nitrites are hydrolyzed by water to form carboxylic acids: RR'C(OH)CN + H2O yields RR'C(OH)CO2H and RR'C(NH2)CN + H2O yields RR'C(NH2)CO2H.

The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AhR signaling: Clues for its role in inflammation and cancer.

PubMed

Vogel, Christoph F A; Haarmann-Stemmann, Thomas

2017-02-01

The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to dimerize with the AhR nuclear translocator (ARNT) and through direct competition of AhR/ARNT and AhRR/ARNT complexes for binding to dioxin-responsive elements (DREs). Like AhR, AhRR belongs to the basic Helix-Loop-Helix/Per-ARNT-Sim (bHLH/PAS) protein family but lacks functional ligand-binding and transactivation domains. Transient transfection experiments with ARNT and AhRR mutants examining the inhibitory mechanism of AhRR suggested a more complex mechanism than the simple mechanism of negative feedback through sequestration of ARNT to regulate AhR signaling. Recently, AhRR has been shown to act as a tumor suppressor gene in several types of cancer cells. Furthermore, epidemiological studies have found epigenetic changes and silencing of AhRR associated with exposure to cigarette smoke and cancer development. Additional studies from our laboratories have demonstrated that AhRR represses other signaling pathways including NF-κB and is capable of regulating inflammatory responses. A better understanding of the regulatory mechanisms of AhRR in AhR signaling and adverse outcome pathways leading to deregulated inflammatory responses contributing to tumor promotion and other adverse health effects is expected from future studies. This review article summarizes the characteristics of AhRR as an inhibitor of AhR activity and highlights more recent findings pointing out the role of AhRR in inflammation and tumorigenesis.

How to stop the science saboteurs

NASA Astrophysics Data System (ADS)

Shears, Tara

2017-06-01

In the current political climate, you may find that author and science journalist Dave Levitan's Not a Scientist: How Politicians Mistake, Misrepresent and Utterly Mangle Science attracts you with the same compulsion that pulls moths towards flames.

RR Lyrae Variables in Stellar Systems

NASA Astrophysics Data System (ADS)

Smith, Horace A.; Catelan, Márcio; Clementini, Gisella

2009-09-01

The pioneering studies of RR Lyrae stars in globular clusters by Oosterhoff and by Sawyer Hogg in the 1930s and 1940s called attention to interesting systematic differences among RR Lyrae populations in different systems. When such studies were extended to the dwarf spheroidal companions of the Milky Way in the 1960s, it was found that the average properties of their RR Lyrae stars were often different from those that had previously been observed in globular clusters. Observations of RR Lyrae stars have now extended to the Andromeda Galaxy and other Local Group systems, with still greater variety being apparent. Our understanding of the reasons for these differences among the RR Lyrae populations in different systems is by no means complete, but properties of RR Lyrae stars within these different systems are tied to differing horizontal branch morphologies and also shed light upon scenarios for the formation of the Galaxy.

[Heart rate variability study based on a novel RdR RR Intervals Scatter Plot].

PubMed

Lu, Hongwei; Lu, Xiuyun; Wang, Chunfang; Hua, Youyuan; Tian, Jiajia; Liu, Shihai

2014-08-01

On the basis of Poincare scatter plot and first order difference scatter plot, a novel heart rate variability (HRV) analysis method based on scatter plots of RR intervals and first order difference of RR intervals (namely, RdR) was proposed. The abscissa of the RdR scatter plot, the x-axis, is RR intervals and the ordinate, y-axis, is the difference between successive RR intervals. The RdR scatter plot includes the information of RR intervals and the difference between successive RR intervals, which captures more HRV information. By RdR scatter plot analysis of some records of MIT-BIH arrhythmias database, we found that the scatter plot of uncoupled premature ventricular contraction (PVC), coupled ventricular bigeminy and ventricular trigeminy PVC had specific graphic characteristics. The RdR scatter plot method has higher detecting performance than the Poincare scatter plot method, and simpler and more intuitive than the first order difference method.

An Efficient Alternative Mixed Randomized Response Procedure

ERIC Educational Resources Information Center

Singh, Housila P.; Tarray, Tanveer A.

2015-01-01

In this article, we have suggested a new modified mixed randomized response (RR) model and studied its properties. It is shown that the proposed mixed RR model is always more efficient than the Kim and Warde's mixed RR model. The proposed mixed RR model has also been extended to stratified sampling. Numerical illustrations and graphical…

77 FR 27085 - R.R. Donnelley, Inc., Bloomsburg, PA; Notice of Negative Determination on Reconsideration

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-80,485] R.R. Donnelley, Inc... workers of R.R. Donnelley, Inc., Bloomsburg, Pennsylvania (subject firm). The Department's Notice of... eligibility to apply for worker adjustment assistance for workers and former workers of R.R. Donnelley, Inc...

[Prognosis in pediatric traumatic brain injury. A dynamic cohort study].

PubMed

Vázquez-Solís, María G; Villa-Manzano, Alberto I; Sánchez-Mosco, Dalia I; Vargas-Lares, José de Jesús; Plascencia-Fernández, Irma

2013-01-01

traumatic brain injury is a main cause of hospital admission and death in children. Our objective was to identify prognostic factors of pediatric traumatic brain injury. this was a dynamic cohort study of traumatic brain injury with 6 months follow-up. The exposition was: mild or moderate/severe traumatic brain injury, searching for prognosis (morbidity-mortality and decreased Glasgow scale). Relative risk and logistic regression was estimated for prognostic factors. we evaluated 440 patients with mild traumatic brain injury and 98 with moderate/severe traumatic brain injury. Morbidity for mild traumatic brain injury was 1 %; for moderate/severe traumatic brain injury, 5 %. There were no deaths. Prognostic factors for moderate/severe traumatic brain injury were associated injuries (RR = 133), fractures (RR = 60), street accidents (RR = 17), night time accidents (RR = 2.3) and weekend accidents (RR = 2). Decreased Glasgow scale was found in 9 %, having as prognostic factors: visible injuries (RR = 3), grown-up supervision (RR = 2.5) and time of progress (RR = 1.6). there should be a prognosis established based on kinetic energy of the injury and not only with Glasgow Scale.

Effect of protected research time on ABSITE scores during general surgery residency.

PubMed

Orkin, Bruce A; Poirier, Jennifer; Kowal-Vern, Areta; Chan, Edie; Ohara, Karen; Mendoza, Brian

2018-02-01

Objective - To determine whether residents with one or more years of dedicated research time (Research Residents, RR) improved their ABSITE scores compared to those without (Non-Research Residents, N-RR). A retrospective review of general surgery residents' ABSITE scores from 1995 to 2016 was performed. RR were compared to N-RR. Additional analysis of At Risk (AR) v Not At Risk residents (NAR) (35th percentile as PGY1-2) was also performed. Cohort - 147 residents (34 RR and 113 N-RR). There were no differences in initial ABSITE scores (p = 0.47). By definition, the AR group had lower scores than NAR. Overall, post-research RR v PGY-4 N-RR scores did not differ (p = 0.84). Only the AR residents improved their scores (p = 0.0009 v NAR p = 0.42), regardless of research group (p = 0.70). Protected research time did not improve residents' ABSITE scores, regardless of initial scores. At Risk residents improved regardless of research group status. Copyright © 2017 Elsevier Inc. All rights reserved.

[The characteristics of RR-Lorenz plot in persistent atrial fibrillation patients complicating with escape beats and rhythm].

PubMed

Pan, Yunping; Zhang, Fangfang; Liu, Ru; Jing, Yan; Shen, Jihong; Li, Zhongjian; Zhu, Huaijie

2014-06-01

To explore the characteristics of RR-Lorenz plot in persistent atrial fibrillation (AF) patients complicating with escape beats and rhythm though ambulatory electrocardiogram. The 24-hour ambulatory electrocardiogram of 291 persistent AF patients in second affiliated hospital of Zhengzhou university from July 2005 to April 2013 were retrospectively analyzed and the RR interval and the QRS wave were measured. Patients were divided into two groups according to the distribution of the RR-Lorenz point [AF without escape beats and rhythm group (Group A, n = 259) and AF with escape beats and rhythm group (Group B, n = 32)]. The characteristics of RR-Lorenz plot between the two groups were compared. (1) Fan-shaped RR-Lorenz plots were evidenced in Group A. (2)In Group B, 30 cases showed fan-shaped with L-shaped and a short dense rods along 45° line. The proportion of escape beats and rhythm was 0.28% (275/98 369) -14.06% (11 263/80 112) . The other 2 cases in group B showed no typical RR-Lorenz plots features. RR-Lorenz plot could help to quickly diagnose persistent AF complicating with escape beats and rhythm according to the typical RR-Lorenz plot characteristics in 24-hour ambulatory electrocardiogram.

Excessive response-repetition costs under task switching: how response inhibition amplifies response conflict.

PubMed

Grzyb, Kai Robin; Hübner, Ronald

2013-01-01

The size of response-repetition (RR) costs, which are usually observed on task-switch trials, strongly varies between conditions with univalent and bivalent stimuli. To test whether top-down or bottom-up processes can account for this effect, we assessed in Experiment 1 baselines for univalent and bivalent stimulus conditions (i.e., for stimuli that are associated with either 1 or 2 tasks). Experiment 2 examined whether the proportion of these stimulus types affects RR costs. As the size of RR costs was independent of proportion, a top-down explanation could be excluded. However, there was an increase in RR costs if the current stimulus induced a response conflict. To account for this effect, we proposed an amplification of response conflict account. It assumes that the basic mechanism that leads to RR costs amplifies response conflict, which, in turn, increases RR costs. Experiment 3 confirmed this bottom-up explanation by showing that the increase in RR costs varies with previous-trial congruency, which is known to affect RR costs. Experiment 4 showed that the increase can also be found with univalent stimuli that induce response conflict. Altogether, the results are in line with a response inhibition account of RR costs. Implications for alternative accounts are also discussed. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY: Effects of concentration and annealing on the performance of regioregular poly(3-hexylthiophene) field-effect transistors

NASA Astrophysics Data System (ADS)

Tian, Xue-Yan; Xu, Zheng; Zhao, Su-Ling; Zhang, Fu-Jun; Yuan, Guang-Cai; Xu, Xu-Rong

2009-08-01

This paper investigates the effects of concentration on the crystalline structure, the morphology, and the charge carrier mobility of regioregular poly(3-hexylthiophene) (RR-P3HT) field-effect transistors (FETs). The RR-P3HT FETs with RR-P3HT as an active layer with different concentrations of RR-P3HT solution from 0.5 wt% to 2 wt% are prepared. The results indicate that the performance of RR-P3HT FETs improves drastically with the increase of RR-P3HT weight percentages in chloroform solution due to the formation of more microcrystalline lamellae and bigger nanoscale islands. It finds that the field-effect mobility of RR-P3HT FET with 2 wt% can reach 5.78 × 10-3 cm2/Vs which is higher by a factor of 13 than that with 0.5 wt%. Further, an appropriate thermal annealing is adopted to improve the performance of RR-P3HT FETs. The field-effect mobility of RR-P3HT FETs increases drastically to 0.09 cm2/Vs by thermal annealing at 150 °C, and the value of on/off current ratio can reach 104.

An evaluation of the psychological impact of operational rest and recuperation in United Kingdom Armed Forces personnel: a post-intervention survey

PubMed Central

Jones, Norman; Fertout, Mohammed; Parsloe, Laura; Greenberg, Neil

2013-01-01

Objective Rest and Recuperation (R&R) is a period of home leave taken during an operational deployment; we sought to examine the relationship between taking R&R and mental health. Design A survey-based post-intervention evaluation. Setting UK Participants 232 members of the UK Armed Forces; 42 of which completed pre and post R&R surveys. Main Outcome Measures Alcohol use, Post Traumatic Stress Disorder, Common Mental Disorder Symptoms and R&R experiences. Results 12.1% of respondents (n=27) reported symptoms of common mental disorder and 3.7% (n=8) reported probable PTSD. 50.0% (n=110) reported hazardous use of alcohol during R&R. In the pre- and post-assessed sample, mental health status and alcohol use levels were similar at both survey points. Using principal component analysis, five components of R&R were identified; mentally switching off from deployment, travel experience, physical recovery, relaxation, rest and social support. R&R was extremely popular and although it did not improve mental health overall, the ability to engage with or derive satisfaction from aspects of the five components was significantly associated with better mental health and less alcohol use at the end of R&R. Conclusion Operational commanders should advise personnel about the best way to actively engage with R&R before they leave theatre and be aware of the significant detrimental impact of disrupted travel arrangements upon the ability to benefit from R&R. PMID:23824329

Worksite safety climate, smoking, and the use of protective equipment by blue collar building workers enrolled in the MassBUILT smoking cessation trial

PubMed Central

Dutra, Lauren M; Kim, Seung-Sup; Williams, David R; Kawachi, Ichiro; Okechukwu, Cassandra A

2014-01-01

Objective In order to assess potential contributors to high injury rates and smoking prevalence among construction workers, we investigated the association of safety climate with personal protective equipment (PPE) use, and smoking behaviors. Methods Logistic regression models estimated risk ratios for PPE use and smoking using data from participants in MassBUILT smoking cessation intervention (n=1,725). Results Contractor safety climate was negatively associated with use of dust masks (RR=0.88,95%CI:0.83–0.94); respirators (RR=0.82,95%CI:0.75–0.89); general equipment (RR=0.98,95%CI:0.95–1.00); and fall protection (RR=0.94,95%CI:0.91–0.98) and positively associated with current smoking (RR=1.12,95%CI:1.01–1.25) but not smoking cessation. Coworker safety climate was negatively associated with use of dust masks (RR=0.87,95%CI:0.82–0.92); respirators (RR=0.80,95%CI:0.74–0.87); general equipment (RR=0.96,95%CI:0.94–0.98); fall (RR=0.92,95%CI:0.89–0.96) and hearing (RR=0.88,95%CI:0.83–0.93) protection but not smoking. Conclusions Worksite safety climate may be important for PPE use and smoking, but further research is needed. PMID:25285831

An evaluation of the psychological impact of operational rest and recuperation in United Kingdom Armed Forces personnel: a post-intervention survey.

PubMed

Jones, Norman; Fertout, Mohammed; Parsloe, Laura; Greenberg, Neil

2013-11-01

Rest and Recuperation (R&R) is a period of home leave taken during an operational deployment; we sought to examine the relationship between taking R&R and mental health. A survey-based post-intervention evaluation. UK PARTICIPANTS: 232 members of the UK Armed Forces; 42 of which completed pre and post R&R surveys. Alcohol use, Post Traumatic Stress Disorder, Common Mental Disorder Symptoms and R&R experiences. 12.1% of respondents (n=27) reported symptoms of common mental disorder and 3.7% (n=8) reported probable PTSD. 50.0% (n=110) reported hazardous use of alcohol during R&R. In the pre- and post-assessed sample, mental health status and alcohol use levels were similar at both survey points. Using principal component analysis, five components of R&R were identified; mentally switching off from deployment, travel experience, physical recovery, relaxation, rest and social support. R&R was extremely popular and although it did not improve mental health overall, the ability to engage with or derive satisfaction from aspects of the five components was significantly associated with better mental health and less alcohol use at the end of R&R. Operational commanders should advise personnel about the best way to actively engage with R&R before they leave theatre and be aware of the significant detrimental impact of disrupted travel arrangements upon the ability to benefit from R&R.

Repeat rates in digital chest radiography and strategies for improvement.

PubMed

Fintelmann, Florian; Pulli, Benjamin; Abedi-Tari, Faezeh; Trombley, Maureen; Shore, Mary-Theresa; Shepard, Jo-Anne; Rosenthal, Daniel I

2012-05-01

To determine the repeat rate (RR) of chest radiographs acquired with portable computed radiography (CR) and installed direct radiography (DR) and to develop and assess strategies designed to decrease the RR. The RR and reasons for repeated digital chest radiographs were documented over the course of 16 months while a task force of thoracic radiologists, technologist supervisors, technologists, and information technology specialists continued to examine the workflow for underlying causes. Interventions decreasing the RR were designed and implemented. The initial RR of digital chest radiographs was 3.6% (138/3818) for portable CR and 13.3% (476/3575) for installed DR systems. By combining RR measurement with workflow analysis, targets for technical and teaching interventions were identified. The interventions decreased the RR to 1.8% (81/4476) for portable CR and to 8.2% (306/3748) for installed DR. We found the RR of direct digital chest radiography to be significantly higher than that of computed chest radiography. We believe this is due to the ease with which repeat images can be obtained and discarded, and it suggests the need for ongoing surveillance of RR. We were able to demonstrate that strategies to lower the RR, which had been developed in the era of film-based imaging, can be adapted to the digital environment. On the basis of our findings, we encourage radiologists to assess their own departmental RRs for direct digital chest radiography and to consider similar interventions if necessary to achieve acceptable RRs for this modality.

Relative activity and referral patterns for diabetes and non-diabetes in general practice.

PubMed

Morgan, C L; Currie, C J; Hunt, J; Evans, J D; Rogers, C; Stott, N C; Peters, J R

2000-03-01

To describe and compare general practice (GP) activity for patients with and without diabetes using a survey of general practices representing over 10% of the Welsh population. The Welsh GP Morbidity Database Project (GPMDP) collected data including demographic and lifestyle information and consultation data such as diagnosis, referral and surgical procedures. These data were analysed to establish the annual period prevalence of diabetes and compare the relative number of consultations and referrals. A total of 4,182 diabetic patients were recorded (prevalence 1.41%) and accounted for 77,371 (4.4%) consultations. Patients with diabetes were four-times more likely to be referred to community services (relative risk (RR) 4.1, 95% CI 3.7-4.7), in particular district nursing (RR 3.8, 1.9-7.7), optician services (RR 8.9, 5.0-15.7), chiropody (RR 8.2 6.4-10.5) and dietician services (RR 21.2, 17.6-25.5). Patients with diabetes were also more likely to be followed-up in general practice (RR 6.7, 6.2-7.2) both within 1 month (RR 6.7, 6.2-7.2) and 1 month to 1 year (RR 9.7, 8.9-10.7). Emergency admissions were also more likely for patients with diabetes (RR 6.8, 6.2-7.5) as were elective admissions to general medicine (RR 5.6, 4.6-6.7), surgery (RR 1.8, 1.5-2.0) and opthalmology (4.2, 3.4-5.2). The increased utilization of health services apparent in secondary care was confirmed in primary care. Further research is required to determine levels of community activity after initial referral.

Evaluation of autonomic functions of patients with multiple system atrophy and Parkinson's disease by head-up tilt test.

PubMed

Watano, Chikako; Shiota, Yuri; Onoda, Keiichi; Sheikh, Abdullah Md; Mishima, Seiji; Nitta, Eri; Yano, Shozo; Yamaguchi, Shuhei; Nagai, Atsushi

2018-02-01

The aim of this study was to evaluate the autonomic neural function in Parkinson's disease (PD) and multiple system atrophy (MSA) with head-up tilt test and spectral analysis of cardiovascular parameters. This study included 15 patients with MSA, 15 patients with PD, and 29 healthy control (HC) subjects. High frequency power of the RR interval (RR-HF), the ratio of low frequency power of RR interval to RR-HF (RR-LF/HF) and LF power of systolic BP were used to evaluate parasympathetic, cardiac sympathetic and vasomotor sympathetic functions, respectively. Both patients with PD and MSA showed orthostatic hypotension and lower parasympathetic function (RR-HF) at tilt position as compared to HC subjects. Cardiac sympathetic function (RR-LF/HF) was significantly high in patients with PD than MSA at supine position. RR-LF/HF tended to increase in MSA and HC, but decreased in PD by tilting. Consequently, the change of the ratio due to tilting (ΔRR-LF/HF) was significantly lower in patients with PD than in HC subjects. Further analysis showed that compared to mild stage of PD, RR-LF/HF at the supine position was significantly higher in advanced stage. By tilting, it was increased in mild stage and decreased in the advanced stage of PD, causing ΔRR-LF/HF to decrease significantly in the advanced stage. Thus, we demonstrated that spectral analysis of cardiovascular parameters is useful to identify sympathetic and parasympathetic disorders in MSA and PD. High cardiac sympathetic function at the supine position, and its reduction by tilting might be a characteristic feature of PD, especially in the advanced stage.

Estimation of the familial relative risk of cancer by site from a French population based family study on colorectal cancer (CCREF study).

PubMed

Andrieu, N; Launoy, G; Guillois, R; Ory-Paoletti, C; Gignoux, M

2004-09-01

Colorectal cancer (CRC) is the second most common cause of death from cancer in France. A family history of CRC increases an individual's risk of developing CRC. Family history has been suggested to have a greater impact on proximal than distal tumours. We estimated the familial risk of CRC and other cancers, and examined how risk varies according to localisation of the tumour in the colorectal tract. We recorded all cases of CRC diagnosed between 1993 and 1998 in the region served by the Calvados Cancer Registry. A trained interviewer asked all participants about their family history of cancer. Familial risk was estimated from a cohort analysis of the relatives of the CRC cases. The expected numbers of cancers were calculated from Calvados incidence rates. Familial relative risks were calculated using standardised incidence ratios. Our findings showed that colon cancer had a stronger familial/genetic component (relative risk (RR) 1.47) than rectal cancer (RR 0.98). The familial/genetic component appeared stronger for proximal colon cancer than for distal colon cancer only among women (RR 2.24 v RR 1.45). CRC appeared to be positively associated with leukaemia (RR 1.77), stomach cancer (RR 1.32), and testicular cancer (RR 3.13), and negatively associated with urinary bladder cancer (RR 0.57) within families. The cancer spectrum associated with CRC among younger participants included prostate (RR 1.93), uterus (RR 2.49), and thyroid (RR 3.85) cancers. If our results are confirmed, follow up guidelines for patients with a family history of CRC should depend on the sex and tumour site of affected relatives to avoid needless invasive screening.

Elevated Plasma Levels of Soluble (Pro)Renin Receptor in Patients with Obstructive Sleep Apnea Syndrome in Parallel with the Disease Severity.

PubMed

Nishijima, Tsuguo; Tajima, Kazuki; Yamashiro, Yoshihiro; Hosokawa, Keisuke; Suwabe, Akira; Takahashi, Kazuhiro; Sakurai, Shigeru

2016-04-01

(Pro)renin receptor ((P)RR), a receptor for renin and prorenin, is implicated in the pathophysiology of diabetes mellitus, hypertension and their complications. Soluble (P)RR (s(P)RR) is composed of extracellular domain of (P)RR and thus exists in blood. We have reported that plasma concentrations of s(P)RR were elevated in male patients with obstructive sleep apnea syndrome (OSAS). The aim of the present study was to clarify the difference in plasma s(P)RR concentrations between male and female OSAS patients. Plasma s(P)RR concentrations were studied in 289 subjects (206 males and 83 females) consisting of 259 OSAS patients and 30 non-OSAS control subjects. The 259 OSAS patients were classified into mild (5 ≤ apnea hypopnea index (AHI) < 15 events/h), moderate (15 ≤ AHI < 30), and severe OSAS (AHI ≥ 30). Plasma s(P)RR levels were significantly elevated in all three OSAS groups compared to non-OSAS control subjects (AHI < 5) in the entire cohort and male subjects, whereas in female subjects, the significant elevation was found only in severe OSAS. Plasma s(P)RR levels were significantly correlated with AHI in both sexes, with a higher r value found in male subjects (male r = 0.413, p < 0.0001; female r = 0.263, p < 0.05). Importantly, when OSAS patients (26 males and 15 females) with AHI ≥ 20 underwent continuous positive airway pressure treatment, plasma s(P)RR levels were significantly decreased. In conclusion, plasma s(P)RR levels are elevated in both male and female OSAS patients in parallel with the disease severity.

Insecticide resistance monitoring and correlation analysis of insecticides in field populations of the brown planthopper Nilaparvata lugens (stål) in China 2012-2014.

PubMed

Zhang, Xiaolei; Liao, Xun; Mao, Kaikai; Zhang, Kaixiong; Wan, Hu; Li, Jianhong

2016-09-01

The brown planthopper is a serious rice pest in China. Chemical insecticides have been considered a satisfactory means of controlling the brown planthopper. In the present study, we determined the susceptibility of twenty-one populations of Nilaparvata lugens to eleven insecticides by a rice-stem dipping method from 2012 to 2014 in eight provinces of China. These field-collected populations of N. lugens had developed high levels of resistance to imidacloprid (resistant ratio, RR=233.3-2029-fold) and buprofezin (RR=147.0-1222). Furthermore, N. lugens showed moderate to high levels of resistance to thiamethoxam (RR=25.9-159.2) and low to moderate levels of resistance to dinotefuran (RR=6.4-29.1), clothianidin (RR=6.1-33.6), ethiprole (RR=11.5-71.8), isoprocarb (RR=17.1-70.2), and chlorpyrifos (RR=7.4-30.7). In contrast, the susceptibility of N. lugens to etofenprox (RR=1.1-4.9), thiacloprid (RR=2.9-8.2) and acetamiprid (RR=2.7-26.2) remained susceptible to moderate levels of resistance. Significant correlations were detected between the LC50 values of imidacloprid and thiamethoxam, dinotefuran, buprofezin, and etofenprox, as well as between clothianidin and thiamethoxam, dinotefuran, ethiprole, acetamiprid, and thiacloprid. Similarly, significant correlations were observed between chlorpyrifos and etofenprox, acetamiprid and thiacloprid. Additionally, the activity of the detoxification enzymes of N. lugens showed a significant correlation with the log LC50 values of imidacloprid, dinotefuran and ethiprole. These results will be beneficial for effective insecticide resistance management strategies to prevent or delay the development of insecticide resistance. Copyright © 2015 Elsevier B.V. All rights reserved.

[Primary Study on Predicting the Termination of Paroxysmal Atrial Fibrillation Based on a Novel RdR RR Intervals Scatter Plot].

PubMed

Lu, Hongwei; Zhang, Chenxi; Sun, Ying; Hao, Zhidong; Wang, Chunfang; Tian, Jiajia

2015-08-01

Predicting the termination of paroxysmal atrial fibrillation (AF) may provide a signal to decide whether there is a need to intervene the AF timely. We proposed a novel RdR RR intervals scatter plot in our study. The abscissa of the RdR scatter plot was set to RR intervals and the ordinate was set as the difference between successive RR intervals. The RdR scatter plot includes information of RR intervals and difference between successive RR intervals, which captures more heart rate variability (HRV) information. By RdR scatter plot analysis of one minute RR intervals for 50 segments with non-terminating AF and immediately terminating AF, it was found that the points in RdR scatter plot of non-terminating AF were more decentralized than the ones of immediately terminating AF. By dividing the RdR scatter plot into uniform grids and counting the number of non-empty grids, non-terminating AF and immediately terminating AF segments were differentiated. By utilizing 49 RR intervals, for 20 segments of learning set, 17 segments were correctly detected, and for 30 segments of test set, 20 segments were detected. While utilizing 66 RR intervals, for 18 segments of learning set, 16 segments were correctly detected, and for 28 segments of test set, 20 segments were detected. The results demonstrated that during the last one minute before the termination of paroxysmal AF, the variance of the RR intervals and the difference of the neighboring two RR intervals became smaller. The termination of paroxysmal AF could be successfully predicted by utilizing the RdR scatter plot, while the predicting accuracy should be further improved.

Same-sex marriage, autoimmune thyroid gland dysfunction and other autoimmune diseases in Denmark 1989-2008.

PubMed

Frisch, Morten; Nielsen, Nete Munk; Pedersen, Bo Vestergaard

2014-01-01

Autoimmune diseases have been little studied in gay men and lesbians. We followed 4.4 million Danes, including 9,615 same-sex married (SSM) persons, for 47 autoimmune diseases in the National Patient Registry between 1989 and 2008. Poisson regression analyses provided first hospitalization rate ratios (RRs) comparing rates between SSM individuals and persons in other marital status categories. SSM individuals experienced no unusual overall risk of autoimmune diseases. However, the risk of autoimmune thyroid dysfunction was increased, notably Hashimoto's thyroiditis (women(SSM), RR = 2.92; 95% confidence interval (CI) 1.74-4.55) and Graves' disease (men(SSM), RR = 1.88; 95% CI 1.08-3.01). There was also an excess of primary biliary cirrhosis (women(SSM), RR = 4.09; 95% CI 1.01-10.7), and of psoriasis (men(SSM), RR = 2.48; 95% CI 1.77-3.36), rheumatic fever (men(SSM), RR = 7.55; 95% CI 1.87-19.8), myasthenia gravis (men(SSM), RR = 5.51; 95% CI 1.36-14.4), localized scleroderma (men(SSM), RR = 7.16; 95% CI 1.18-22.6) and pemphigoid (men(SSM), RR = 6.56; 95% CI 1.08-20.6), while Dupuytren's contracture was reduced (men(SSM), RR = 0.64; 95% CI 0.39-0.99). The excess of psoriasis was restricted to same-sex married men with HIV/AIDS (men(SSM), RR = 10.5; 95% CI 6.44-15.9), whereas Graves' disease occurred in excess only among same-sex married men without HIV/AIDS (men(SSM), RR = 1.99; 95% CI 1.12-3.22). Lesbians and immunologically competent gay men in same-sex marriage face no unusual overall risk of autoimmune diseases. However, the observed increased risk of thyroid dysfunction in these lesbians and gay men deserves further study.

Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathways

PubMed Central

Joseph, Marie G.; Denninger, John W.; Fricchione, Gregory L.; Benson, Herbert; Libermann, Towia A.

2013-01-01

The relaxation response (RR) is the counterpart of the stress response. Millennia-old practices evoking the RR include meditation, yoga and repetitive prayer. Although RR elicitation is an effective therapeutic intervention that counteracts the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and aging, the underlying molecular mechanisms that explain these clinical benefits remain undetermined. To assess rapid time-dependent (temporal) genomic changes during one session of RR practice among healthy practitioners with years of RR practice and also in novices before and after 8 weeks of RR training, we measured the transcriptome in peripheral blood prior to, immediately after, and 15 minutes after listening to an RR-eliciting or a health education CD. Both short-term and long-term practitioners evoked significant temporal gene expression changes with greater significance in the latter as compared to novices. RR practice enhanced expression of genes associated with energy metabolism, mitochondrial function, insulin secretion and telomere maintenance, and reduced expression of genes linked to inflammatory response and stress-related pathways. Interactive network analyses of RR-affected pathways identified mitochondrial ATP synthase and insulin (INS) as top upregulated critical molecules (focus hubs) and NF-κB pathway genes as top downregulated focus hubs. Our results for the first time indicate that RR elicitation, particularly after long-term practice, may evoke its downstream health benefits by improving mitochondrial energy production and utilization and thus promoting mitochondrial resiliency through upregulation of ATPase and insulin function. Mitochondrial resiliency might also be promoted by RR-induced downregulation of NF-κB-associated upstream and downstream targets that mitigates stress. PMID:23650531

Heart-specific overexpression of (pro)renin receptor induces atrial fibrillation in mice.

PubMed

Lian, Hong; Wang, Xiaojian; Wang, Juan; Liu, Ning; Zhang, Li; Lu, Yingdong; Yang, Yanmin; Zhang, Lianfeng

2015-04-01

Atrial fibrillation (AF) is the most common cardiac arrhythmia, causing substantial cardiovascular morbidity and mortality. The renin-angiotensin system (RAS) has been shown to be involved in the pathophysiology of AF. The (pro)renin receptor [(p)RR] is the last identified member of RAS. However, the role of (p)RR in AF is still unknown. Circulating levels of (p)RR were determined using an immunosorbent assay in 22 patients with AF (paroxysmal or persistent) and 22 healthy individuals. The plasma levels of (p)RR increased 3.6-fold in AF patients (P<0.001), indicating a relationship between (p)RR and AF. To investigate the role of (p)RR in the regulation of cardiac arrhythmia, we generated a transgenic mouse with overexpression of human (p)RR gene specifically in the heart. Electrocardiograms from (p)RR transgenic mice showed typical atrial flutter since 2 months, then spontaneously converted to atrial fibrillation by 10 months. The atria of the transgenic mice demonstrated significant dilation and fibrosis, and exhibited a high incidence of sudden death. Additionally, the genes of SERCA and HCN4, which are involved in the electrophysiology of AF, were significantly down-regulated and up-regulated respectively in transgenic mice atria. The phosphorylation of Erk1/2 significantly increased in the atria of the transgenic mice, and the activated Erk1/2 was found predominantly in cardiac fibroblasts, suggesting that the transgenic (p)RR gene may induce atrial fibrillation by activation of Erk1/2 in the cardiac fibroblasts of the atria. (p)RR promotes atrial structural and electrical remodeling in vivo, which indicates that (p)RR plays an important role in the pathological development of AF. Copyright © 2015. Published by Elsevier Ireland Ltd.

Epidemiologic analysis of an urban, public emergency department's frequent users.

PubMed

Mandelberg, J H; Kuhn, R E; Kohn, M A

2000-06-01

To determine how the demographic, clinical, and utilization characteristics of emergency department (ED) frequent users differ from those of other ED patients. A cross-sectional and retrospective cohort study was performed using a database of all 348,858 visits to the San Francisco General Hospital ED during a five-year period (July 1, 1993, to June 30, 1998). A "frequent user" visited the ED five or more times in a 12-month period. Frequent users constituted 3.9% of ED patients but accounted for 20.5% of ED visits. The relative risk (RR) of frequent use was high among patients who were homeless (RR = 4.5), African American (RR = 1.8), and Medi-Cal sponsored (RR = 2.1). Frequent users were more likely to be seen for alcohol withdrawal (RR = 4.4), alcohol dependence (RR = 3.4), and alcohol intoxication (RR = 2.4). Frequent users were also more likely to visit for exacerbations of chronic conditions, including sickle cell anemia (RR = 8.0), renal failure (RR = 3.6), and chronic obstructive pulmonary disease (RR = 3.3). They were less likely to visit for all forms of trauma (RR = 0.43). Survival analysis showed that only 38% of frequent users for one year remained frequent users the next year. However, 56% of frequent users for two consecutive years remained frequent users in the third year. Frequent use of the ED reflects the urban social problems of homelessness, poverty, alcohol abuse, and chronic illness. Frequent use of the ED shows a high rate of decline from one year to the next. This rate of decline slows after the first year and suggests the existence of a smaller group of chronic frequent users.

Can we improve the clinical utility of respiratory rate as a monitored vital sign?

PubMed

Chen, Liangyou; Reisner, Andrew T; Gribok, Andrei; McKenna, Thomas M; Reifman, Jaques

2009-06-01

Respiratory rate (RR) is a basic vital sign, measured and monitored throughout a wide spectrum of health care settings, although RR is historically difficult to measure in a reliable fashion. We explore an automated method that computes RR only during intervals of clean, regular, and consistent respiration and investigate its diagnostic use in a retrospective analysis of prehospital trauma casualties. At least 5 s of basic vital signs, including heart rate, RR, and systolic, diastolic, and mean arterial blood pressures, were continuously collected from 326 spontaneously breathing trauma casualties during helicopter transport to a level I trauma center. "Reliable" RR data were identified retrospectively using automated algorithms. The diagnostic performances of reliable versus standard RR were evaluated by calculation of the receiver operating characteristic curves using the maximum-likelihood method and comparison of the summary areas under the receiver operating characteristic curves (AUCs). Respiratory rate shows significant data-reliability differences. For identifying prehospital casualties who subsequently receive a respiratory intervention (hospital intubation or tube thoracotomy), standard RR yields an AUC of 0.59 (95% confidence interval, 0.48-0.69), whereas reliable RR yields an AUC of 0.67 (0.57-0.77), P < 0.05. For identifying casualties subsequently diagnosed with a major hemorrhagic injury and requiring blood transfusion, standard RR yields an AUC of 0.60 (0.49-0.70), whereas reliable RR yields 0.77 (0.67-0.85), P < 0.001. Reliable RR, as determined by an automated algorithm, is a useful parameter for the diagnosis of respiratory pathology and major hemorrhage in a trauma population. It may be a useful input to a wide variety of clinical scores and automated decision-support algorithms.

Locations and Mucosal Lesions Responsible for Major Gastrointestinal Bleeding in Patients on Warfarin or Dabigatran.

PubMed

Kolb, Jennifer M; Flack, Kathryn Friedman; Chatterjee-Murphy, Prapti; Desai, Jay; Wallentin, Lars C; Ezekowitz, Michael; Connolly, Stuart; Reilly, Paul; Brueckmann, Martina; Ilgenfritz, John; Aisenberg, James

2018-03-27

Different oral anticoagulants may be associated with gastrointestinal bleeding (GIB) from different locations or mucosal lesions. We aimed to test this hypothesis. Two blinded gastroenterologists independently analyzed source documents from the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial of dabigatran 150 mg BID (D150), dabigatran 110 mg BID (D110) versus warfarin in non-valvular atrial fibrillation (NVAF). Major GIB events (total n = 546) and life-threatening GIB events (n = 258) were more common with D150 versus warfarin (RR 1.57 [1.28-1.92] and RR 1.62 [1.20-2.18], respectively) and similar for D110 compared to warfarin (RR 1.11 [0.89-1.38] and RR 1.16 [0.84-1.61], respectively). Fatal bleeding was similarly rare across treatment groups. Lower GI major bleeding and life-threatening bleeding were more common with D150 compared to warfarin (RR 2.23 [1.47, 3.38] and RR 2.64 [1.36, 5.13], respectively) and with D110 compared to warfarin (RR 1.78 [1.16, 2.75] and RR 2.00 [1.00, 4.00], respectively). MGIB from colonic angiodysplasia was increased with dabigatran versus warfarin (P < 0.01 for both dose comparisons). Subacute and chronic MGIB events were more common with D150 than with warfarin (RR 1.72 [1.06, 2.78] and RR 1.66 [1.12, 2.45], respectively), as were hematochezia or melena (RR 1.67 [1.18, 2.36] and RR 1.72 [1.20, 2.47], respectively). In a chronic NVAF population, D150 but not D110 is associated with increased major and life-threatening GI bleeding in comparison with warfarin. At both dabigatran doses, increased bleeding from the colorectum, in particular from angiodysplasia, is seen.

Differential sensitivity of TREK–1, TREK–2 and TRAAK background potassium channels to the polycationic dye ruthenium red

PubMed Central

Braun, G; Lengyel, M; Enyedi, P; Czirják, G

2015-01-01

Background and Purpose Pharmacological separation of the background potassium currents of closely related K2P channels is a challenging problem. We previously demonstrated that ruthenium red (RR) inhibits TASK-3 (K2P9.1), but not TASK-1 (K2P3.1) channels. RR has been extensively used to distinguish between TASK currents in native cells. In the present study, we systematically investigate the RR sensitivity of a more comprehensive set of K2P channels. Experimental Approach K+ currents were measured by two-electrode voltage clamp in Xenopus oocytes and by whole-cell patch clamp in mouse dorsal root ganglion (DRG) neurons. Key Results RR differentiates between two closely related members of the TREK subfamily. TREK-2 (K2P10.1) proved to be highly sensitive to RR (IC50 = 0.2 μM), whereas TREK-1 (K2P2.1) was not affected by the compound. We identified aspartate 135 (D135) as the target of the inhibitor in mouse TREK-2c. D135 lines the wall of the extracellular ion pathway (EIP), a tunnel structure through the extracellular cap characteristic for K2P channels. TREK-1 contains isoleucine in the corresponding position. The mutation of this isoleucine (I110D) rendered TREK-1 sensitive to RR. The third member of the TREK subfamily, TRAAK (K2P4.1) was more potently inhibited by ruthenium violet, a contaminant in some RR preparations, than by RR. DRG neurons predominantly express TREK-2 and RR-resistant TREK-1 and TRESK (K2P18.1) background K+ channels. We detected the RR-sensitive leak K+ current component in DRG neurons. Conclusions and Implications We propose that RR may be useful for distinguishing TREK-2 (K2P10.1) from TREK-1 (K2P2.1) and other RR-resistant K2P channels in native cells. PMID:25409575

Rapid-rate nonsustained ventricular tachycardia found on implantable cardioverter-defibrillator interrogation: relationship to outcomes in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

PubMed

Chen, Jay; Johnson, George; Hellkamp, Anne S; Anderson, Jill; Mark, Daniel B; Lee, Kerry L; Bardy, Gust H; Poole, Jeanne E

2013-05-28

The aim of this study was to examine rapid-rate nonsustained ventricular tachycardia (RR-NSVT) during routine implantable cardioverter-defibrillator (ICD) evaluation in patients with heart failure and its relationship to outcomes. The clinical implications of RR-NSVT identified during routine ICD interrogation are unclear. In this study, the occurrence of RR-NSVT and its association with ICD shocks and mortality in SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) were examined. The 811 patients who received ICDs in SCD-HeFT constituted the study population. The occurrence of RR-NSVT and its association with ICD shocks and mortality in SCD-HeFT were examined. RR-NSVT was documented on ICD interrogation in 186 of 811 patients (22.9%). The mean duration of RR-NSVT was 26.4 ± 9.1 beats (7.5 ± 2.6 s), with a mean cycle length of 259 ± 32 ms. Polymorphic RR-NSVT accounted for 56% of episodes. Compared with patients without RR-NSVT, those with RR-NSVT were less likely to be taking beta-blockers, statins, or aspirin at enrollment. After adjusting for other known predictors of mortality in SCD-HeFT, RR-NSVT was independently associated with appropriate ICD shocks (hazard ratio: 4.25; 95% confidence interval: 2.94 to 6.14; p < 0.0001), with all-cause mortality (hazard ratio: 2.40; 95% confidence interval: 1.62 to 3.54; p < 0.0001), and with a composite of all-cause mortality and appropriate ICD shocks (hazard ratio: 3.03; 95% confidence interval: 2.21 to 4.15; p < 0.0001). RR-NSVT identified on routine ICD interrogation should be considered an important clinical event. RR-NSVT during ICD interrogation is associated with appropriate ICD shocks and all-cause mortality. The clinical evaluation of patients with RR-NSVT should include intensification of medical therapy, particularly beta-blockers, or other appropriate clinical interventions. (Sudden Cardiac Death in Heart Failure Trial [SCD-HeFT]; NCT00000609). Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

[A three-year follow-up study on the transfer of mild cognitive impairment to Alzheimer's disease among the elderly in Taiyuan city].

PubMed

Wang, Yan-ping; Zhai, Jing-bo; Zhu, Fang; Zhang, Wen-wen; Yang, Xiao-juan; Qu, Cheng-yi

2011-02-01

To explore the incidence rate of people with mild cognitive impairment (MCI) which transferred to Alzheimer's disease (AD) and to study the related influencing factors. 600 MCI aged people were experienced screening test which was conducted by WHO-BCA, MMSE and DCR. A three-year follow-up study was conducted to get the information on the aged people with MCI. Data related to demography, behavior, chronic diseases and perception of the elderly with MCI were collected through face to face interview. Characteristics of the elderly with MCI aged people were tested by 16PF. The content of Apoe was tested by PCR. People with NC were investigated by telephone to get the progression and the time to AD. Methodologies on statistics were log-rank test and Cox proportional hazards regression model. The incidence rate of MCI to AD was 6.53% person-years. The incidence rate of the normal people to AD was 1.24% person-years. The hazard of MCI to AD was 5.27 times (95%CI: 3.01 - 9.82) of the normal people to AD. The result of Cox proportional hazards regression model displayed that:older age (RR = 3.14, 95%CI: 2.98 - 7.46), hypertension (RR = 3.28, 95%CI: 3.02 - 8.48), hyperlipemia (RR = 2.22, 95%CI: 1.29 - 3.82), diabetes (RR = 4.87, 95%CI: 2.56 - 9.25), lack of sports (RR = 2.02, 95%CI: 1.29-3.14), anxiety (RR = 4.46, 95%CI: 3.07 - 8.14), dread fullness (RR = 4.08, 95%CI: 3.52 - 5.25), loneliness (RR = 1.89, 95%CI: 1.13 - 3.16), characteristics of anxiety (RR = 5.07, 95%CI: 2.56 - 10.04, introvert characteristics (RR = 2.05, 95%CI: 1.33 - 3.15) and ApoE4 (RR = 1.73, 95%CI: 1.15 - 2.63) were the risk factors of MCI to AD. Higher education (RR = 0.29, 95%CI: 0.07 - 0.43), intellectual work (RR = 0.14, 95%CI: 0.05 - 0.32), often reading books (RR = 0.30, 95%CI: 0.15 - 0.58), often taking part in recreational activities (RR = 0.41, 95%CI: 0.23 - 0.75) seemed to be the protective of MCI to AD. The rate of the elderly with MCI that developing to AD was high, suggesting further study on the cognitive situation among the MCI aged people should be carried out.

VizieR Online Data Catalog: Standard Galactic field RR Lyrae. I. Photometry (Monson+, 2017)

NASA Astrophysics Data System (ADS)

Monson, A. J.; Beaton, R. L.; Scowcroft, V.; Freedman, W. L.; Madore, B. F.; Rich, J. A.; Seibert, M.; Kollmeier, J. A.; Clementini, G.

2017-06-01

The Three-hundred MilliMeter Telescope (TMMT) is a fully robotic, 300mm telescope at Las Campanas Observatory (LCO), for which the nightly operation and data processing have been completely automated. Over the course of two years data were collected on 179 individual nights for our sample of the 55 RR Lyrae in the B, V, and IC broadband filters. Of these nights, 76 were under photometric conditions and calibrated directly. The 103 nonphotometric nights were roughly calibrated by using the default transformation equations, but only provide differential photometry relative to the calibrated frames. This resulted in 59698 final individual observations. Individual data points have a typical photometric precision of 0.02mag. The statistical error falls rapidly with hundreds of observations, with the zero-point uncertainties being the largest source of uncertainty in the final reported mean magnitude. To compare the results of our TMMT campaign to previous studies of these RR Lyrae (RRL) and to fill gaps in our TMMT phase coverage, we have compiled available broadband data from literature published over the past 30 years and spanning our full wavelength coverage (0.4 to 4.5μm) from the optical to mid-infrared. We have homogenized these diverse data sets to the following filter systems: Johnson UBV, Kron-Cousins RI, 2MASS J,H,Ks, and Spitzer [3.6], [4.5]. The All Sky Automated Survey (ASAS; http://www.astrouw.edu.pl/asas/) is a long-term project monitoring all stars brighter than V~14mag. The program covers both hemispheres, with telescopes at Las Campanas Observatory in Chile and Haleakala on Maui, both of which provide simultaneous I and V photometry. The GEOS RR Lyr Survey (http://www.ast.obs-mip.fr/users/leborgne/dbRR/grrs.html) is a long-term program utilizing TAROT (http://tarot.obs-hp.fr/) at Calern Observatory (Nice University, France). Annual data releases from this project add times for maximum light for program stars over the last year of observations. In addition to the large programs previously described, we use optical data from individual studies over the past 30 years (Barnes et al. 1992PASP..104..514B, Cacciari et al. 1987A&AS...69..135C, Skillen et al. 1993SAAOC..15...90S, Liu & Janes 1989ApJS...69..593L, Paczynski 1965AcA....15..115P, Jones et al. 1992ApJ...386..646J, Warren 1966MNSSA..25..103W, Fernley et al. 1989MNRAS.236..447F, Fernley et al. 1990MNRAS.242..685F, and Clementini et al. 2000AJ....120.2054C). Single-epoch photometry is available from 2MASS (Cutri et al. 2003, Cat. II/246) in J, H, and Ks. Data from Sollima et al. 2008 (Cat. J/MNRAS/384/1583), Liu & Janes 1989ApJS...69..593L, Barnes et al. 1992PASP..104..514B, and Fernley et al. 1993A&AS...97..815F, Skillen et al. 1989MNRAS.241..281S, Fernley et al. 1990MNRAS.242..685F, Fernley et al. 1989MNRAS.236..447F and Skillen et al. 1993MNRAS.265..301S are adopted. The mid-infrared [3.6] and [4.5] observations were taken using Spitzer/IRAC as part of the Warm-Spitzer Exploration Science Carnegie RR Lyrae Program (CRRP; PID 90002, Freedman et al. 2012sptz.prop90002F). WISE (Wright et al. 2010AJ....140.1868W; see also Cutri et al. 2012, Cat. II/311) or NEOWISE (Mainzer et al. 2011ApJ...731...53M, Mainzer et al. 2014, Cat. J/ApJ/792/30) photometry is available for each of our stars. (5 data files).

Richard M. Nixon's Rhetorical Strategies in His Public Statements on Watergate.

ERIC Educational Resources Information Center

Benoit, William L.

1982-01-01

Identifies nine rhetorical strategies in Nixon's public utterances on Watergate and traces their development through four phases. Examines polls which reveal that these strategies failed to stem the tide of negative opinion. (PD)

Speech acts and performances of scientific citizenship: Examining how scientists talk about therapeutic cloning.

PubMed

Marks, Nicola J

2014-07-01

Scientists play an important role in framing public engagement with science. Their language can facilitate or impede particular interactions taking place with particular citizens: scientists' "speech acts" can "perform" different types of "scientific citizenship". This paper examines how scientists in Australia talked about therapeutic cloning during interviews and during the 2006 parliamentary debates on stem cell research. Some avoided complex labels, thereby facilitating public examination of this field. Others drew on language that only opens a space for publics to become educated, not to participate in a more meaningful way. Importantly, public utterances made by scientists here contrast with common international utterances: they did not focus on the therapeutic but the research promises of therapeutic cloning. Social scientists need to pay attention to the performative aspects of language in order to promote genuine citizen involvement in techno-science. Speech Act Theory is a useful analytical tool for this.

Validity of a parent-report measure of vocabulary and grammar for Spanish-speaking toddlers.

PubMed

Thal, D; Jackson-Maldonado, D; Acosta, D

2000-10-01

The validity of the Fundación MacArthur Inventario del Desarrollo de Habilidades Comunicativas: Palabras y Enunciados (IDHC:PE) was examined with twenty 20- and nineteen 28-month-old, typically developing, monolingual, Spanish-speaking children living in Mexico. One measure of vocabulary (number of words) and two measures of grammar (mean of the three longest utterances and grammatical complexity score) from the IDHC:PE were compared to behavioral measures of vocabulary (number of different words from a language sample and number of objects named in a confrontation naming task) and one behavioral measure of grammar (mean length of utterance from a language sample). Only vocabulary measures were assessed in the 20-month-olds because of floor effects on the grammar measures. Results indicated validity for assessing expressive vocabulary in 20-month-olds and expressive vocabulary and grammar in 28-month-olds.

Perceptual chunking and its effect on memory in speech processing: ERP and behavioral evidence

PubMed Central

Gilbert, Annie C.; Boucher, Victor J.; Jemel, Boutheina

2014-01-01

We examined how perceptual chunks of varying size in utterances can influence immediate memory of heard items (monosyllabic words). Using behavioral measures and event-related potentials (N400) we evaluated the quality of the memory trace for targets taken from perceived temporal groups (TGs) of three and four items. Variations in the amplitude of the N400 showed a better memory trace for items presented in TGs of three compared to those in groups of four. Analyses of behavioral responses along with P300 components also revealed effects of chunk position in the utterance. This is the first study to measure the online effects of perceptual chunks on the memory trace of spoken items. Taken together, the N400 and P300 responses demonstrate that the perceptual chunking of speech facilitates information buffering and a processing on a chunk-by-chunk basis. PMID:24678304

Perceptual chunking and its effect on memory in speech processing: ERP and behavioral evidence.

PubMed

Gilbert, Annie C; Boucher, Victor J; Jemel, Boutheina

2014-01-01

We examined how perceptual chunks of varying size in utterances can influence immediate memory of heard items (monosyllabic words). Using behavioral measures and event-related potentials (N400) we evaluated the quality of the memory trace for targets taken from perceived temporal groups (TGs) of three and four items. Variations in the amplitude of the N400 showed a better memory trace for items presented in TGs of three compared to those in groups of four. Analyses of behavioral responses along with P300 components also revealed effects of chunk position in the utterance. This is the first study to measure the online effects of perceptual chunks on the memory trace of spoken items. Taken together, the N400 and P300 responses demonstrate that the perceptual chunking of speech facilitates information buffering and a processing on a chunk-by-chunk basis.

Analyzing the Language of Therapist Empathy in Motivational Interview based Psychotherapy

PubMed Central

Xiao, Bo; Can, Dogan; Georgiou, Panayiotis G.; Atkins, David; Narayanan, Shrikanth S.

2016-01-01

Empathy is an important aspect of social communication, especially in medical and psychotherapy applications. Measures of empathy can offer insights into the quality of therapy. We use an N-gram language model based maximum likelihood strategy to classify empathic versus non-empathic utterances and report the precision and recall of classification for various parameters. High recall is obtained with unigram while bigram features achieved the highest F1-score. Based on the utterance level models, a group of lexical features are extracted at the therapy session level. The effectiveness of these features in modeling session level annotator perceptions of empathy is evaluated through correlation with expert-coded session level empathy scores. Our combined feature set achieved a correlation of 0.558 between predicted and expert-coded empathy scores. Results also suggest that the longer term empathy perception process may be more related to isolated empathic salient events. PMID:27602411

Ways of looking ahead: hierarchical planning in language production.

PubMed

Lee, Eun-Kyung; Brown-Schmidt, Sarah; Watson, Duane G

2013-12-01

It is generally assumed that language production proceeds incrementally, with chunks of linguistic structure planned ahead of speech. Extensive research has examined the scope of language production and suggests that the size of planned chunks varies across contexts (Ferreira & Swets, 2002; Wagner & Jescheniak, 2010). By contrast, relatively little is known about the structure of advance planning, specifically whether planning proceeds incrementally according to the surface structure of the utterance, or whether speakers plan according to the hierarchical relationships between utterance elements. In two experiments, we examine the structure and scope of lexical planning in language production using a picture description task. Analyses of speech onset times and word durations show that speakers engage in hierarchical planning such that structurally dependent lexical items are planned together and that hierarchical planning occurs for both direct and indirect dependencies. Copyright © 2013 Elsevier B.V. All rights reserved.

Input Sources of Third Person Singular –s Inconsistency in Children with and without Specific Language Impairment*

PubMed Central

Leonard, Laurence B.; Fey, Marc E.; Deevy, Patricia; Bredin-Oja, Shelley L.

2015-01-01

We tested four predictions based on the assumption that optional infinitives can be attributed to properties of the input whereby children inappropriately extract nonfinite subject-verb sequences (e.g. the girl run) from larger input utterances (e.g. Does the girl run? Let’s watch the girl run). Thirty children with specific language impairment (SLI) and 30 typically developing children heard novel and familiar verbs that appeared exclusively either in utterances containing nonfinite subject-verb sequences or in simple sentences with the verb inflected for third person singular –s. Subsequent testing showed strong input effects, especially for the SLI group. The results provide support for input-based factors as significant contributors not only to the optional infinitive period in typical development, but also to the especially protracted optional infinitive period seen in SLI. PMID:25076070

Deontic reasoning as a target of selection: reply to Astington and Dack.

PubMed

Cummins, Denise Dellarosa

2013-12-01

In their discussion of young children's deontic reasoning performance, Astington and Dack (2013) made the following claims: (1) Children need more cues to elicit cogent social norm reasoning than adults require, namely, explicit reference to authority; (2) Deontic reasoning improves with age, and this is evidence against a nativist view; (3) All evolutionary explanations of deontic reasoning advantages require positing a ''domain-specific deontic reasoning module."; and (4) young children excel at deontic reasoning because it is easier. Here, I refute each claim. Instead, I argue that (1) Social norm reasoning is one type of deontic reasoning that has been the target of selective pressure; (2) Development does not preclude nativism; (3) Epistemic utterances make no greater processing demands than deontic utterances; and (4) both adult and child norm reasoning performance is strongly influenced by reference to or implication of authority. Copyright © 2013 Elsevier Inc. All rights reserved.

Managing students' learning in classrooms: Reframing classroom research

NASA Astrophysics Data System (ADS)

Fawns, Rod; Salder, Jo

1996-06-01

Research on improving teaching typically focuses on the public statements of teachers and students. In the treatment of transcripts only the public “on task” utterances are usually coded and formally enter the research. In this paper the authors analysed Year 8 students' public and private statements to themselves and their peers collected in the course of their multi-year study of teacher management of communication in cooperative learning groups. The authors analysed the students' utterances as data about their cognitive and emotional responses to the management strategies The data reflect how the students perceived and responded to subtle features in the public enactment of the curriculum, the task and the setting during the ongoing lesson. The approach allows a better understanding of students' actual experiences, their responses to the overt and covert curriculum, their use of prior knowledge and their strategies for engaging with the science curriculum.

Consumer Satisfaction with Antipsychotic Medication Monitoring Appointments: The Role of Consumer-Prescriber Communication Patterns

PubMed Central

Reich, Catherine M.; Hack, Samantha M.; Klingaman, Elizabeth A.; Brown, Clayton H.; Fang, Li Juan; Dixon, Lisa B.; Jahn, Danielle R.; Kreyenbuhl, Julie A.

2017-01-01

Objective The study was designed to explore patterns of prescriber communication behaviors as they relate to consumer satisfaction among a serious mental illness sample. Methods Recordings from 175 antipsychotic medication-monitoring appointments between veterans with psychiatric disorders and their prescribers were coded using the Roter Interaction Analysis System (RIAS) for communication behavioral patterns. Results The frequency of prescriber communication behaviors (i.e., facilitation, rapport, procedural, psychosocial, biomedical, and total utterances) did not reliably predict consumer satisfaction. The ratio of prescriber to consumer utterances did predict consumer satisfaction. Conclusion Consistent with client-centered care theory, antipsychotic medication consumers were more satisfied with their encounters when their prescriber did not dominate the conversation. Practice Implications Therefore, one potential recommendation from these findings could be for medication prescribers to spend more of their time listening to, rather than speaking with, their SMI consumers. PMID:28920491

Clustered functional MRI of overt speech production.

PubMed

Sörös, Peter; Sokoloff, Lisa Guttman; Bose, Arpita; McIntosh, Anthony R; Graham, Simon J; Stuss, Donald T

2006-08-01

To investigate the neural network of overt speech production, event-related fMRI was performed in 9 young healthy adult volunteers. A clustered image acquisition technique was chosen to minimize speech-related movement artifacts. Functional images were acquired during the production of oral movements and of speech of increasing complexity (isolated vowel as well as monosyllabic and trisyllabic utterances). This imaging technique and behavioral task enabled depiction of the articulo-phonologic network of speech production from the supplementary motor area at the cranial end to the red nucleus at the caudal end. Speaking a single vowel and performing simple oral movements involved very similar activation of the cortical and subcortical motor systems. More complex, polysyllabic utterances were associated with additional activation in the bilateral cerebellum, reflecting increased demand on speech motor control, and additional activation in the bilateral temporal cortex, reflecting the stronger involvement of phonologic processing.

Rhythmic patterning in Malaysian and Singapore English.

PubMed

Tan, Rachel Siew Kuang; Low, Ee-Ling

2014-06-01

Previous work on the rhythm of Malaysian English has been based on impressionistic observations. This paper utilizes acoustic analysis to measure the rhythmic patterns of Malaysian English. Recordings of the read speech and spontaneous speech of 10 Malaysian English speakers were analyzed and compared with recordings of an equivalent sample of Singaporean English speakers. Analysis was done using two rhythmic indexes, the PVI and VarcoV. It was found that although the rhythm of read speech of the Singaporean speakers was syllable-based as described by previous studies, the rhythm of the Malaysian speakers was even more syllable-based. Analysis of the syllables in specific utterances showed that Malaysian speakers did not reduce vowels as much as Singaporean speakers in cases of syllables in utterances. Results of the spontaneous speech confirmed the findings for the read speech; that is, the same rhythmic patterning was found which normally triggers vowel reductions.

Expression of Emotion in Eastern and Western Music Mirrors Vocalization

PubMed Central

Bowling, Daniel Liu; Sundararajan, Janani; Han, Shui'er; Purves, Dale

2012-01-01

In Western music, the major mode is typically used to convey excited, happy, bright or martial emotions, whereas the minor mode typically conveys subdued, sad or dark emotions. Recent studies indicate that the differences between these modes parallel differences between the prosodic and spectral characteristics of voiced speech sounds uttered in corresponding emotional states. Here we ask whether tonality and emotion are similarly linked in an Eastern musical tradition. The results show that the tonal relationships used to express positive/excited and negative/subdued emotions in classical South Indian music are much the same as those used in Western music. Moreover, tonal variations in the prosody of English and Tamil speech uttered in different emotional states are parallel to the tonal trends in music. These results are consistent with the hypothesis that the association between musical tonality and emotion is based on universal vocal characteristics of different affective states. PMID:22431970

Longitudinal development of communication in children with cerebral palsy between 24 and 53 months: Predicting speech outcomes.

PubMed

Hustad, Katherine C; Allison, Kristen M; Sakash, Ashley; McFadd, Emily; Broman, Aimee Teo; Rathouz, Paul J

2017-08-01

To determine whether communication at 2 years predicted communication at 4 years in children with cerebral palsy (CP); and whether the age a child first produces words imitatively predicts change in speech production. 30 children (15 males) with CP participated and were seen 5 times at 6-month intervals between 24 and 53 months (mean age at time 1 = 26.9 months (SD 1.9)). Variables were communication classification at 24 and 53 months, age that children were first able to produce words imitatively, single-word intelligibility, and longest utterance produced. Communication at 24 months was highly predictive of abilities at 53 months. Speaking earlier led to faster gains in intelligibility and length of utterance and better outcomes at 53 months than speaking later. Inability to speak at 24 months indicates greater speech and language difficulty at 53 months and a strong need for early communication intervention.

Targeted Help for Spoken Dialogue Systems: Intelligent Feedback Improves Naive Users' Performance

NASA Technical Reports Server (NTRS)

Hockey, Beth Ann; Lemon, Oliver; Campana, Ellen; Hiatt, Laura; Aist, Gregory; Hieronymous, Jim; Gruenstein, Alexander; Dowding, John

2003-01-01

We present experimental evidence that providing naive users of a spoken dialogue system with immediate help messages related to their out-of-coverage utterances improves their success in using the system. A grammar-based recognizer and a Statistical Language Model (SLM) recognizer are run simultaneously. If the grammar-based recognizer suceeds, the less accurate SLM recognizer hypothesis is not used. When the grammar-based recognizer fails and the SLM recognizer produces a recognition hypothesis, this result is used by the Targeted Help agent to give the user feed-back on what was recognized, a diagnosis of what was problematic about the utterance, and a related in-coverage example. The in-coverage example is intended to encourage alignment between user inputs and the language model of the system. We report on controlled experiments on a spoken dialogue system for command and control of a simulated robotic helicopter.

Speech target modulates speaking induced suppression in auditory cortex

PubMed Central

Ventura, Maria I; Nagarajan, Srikantan S; Houde, John F

2009-01-01

Background Previous magnetoencephalography (MEG) studies have demonstrated speaking-induced suppression (SIS) in the auditory cortex during vocalization tasks wherein the M100 response to a subject's own speaking is reduced compared to the response when they hear playback of their speech. Results The present MEG study investigated the effects of utterance rapidity and complexity on SIS: The greatest difference between speak and listen M100 amplitudes (i.e., most SIS) was found in the simple speech task. As the utterances became more rapid and complex, SIS was significantly reduced (p = 0.0003). Conclusion These findings are highly consistent with our model of how auditory feedback is processed during speaking, where incoming feedback is compared with an efference-copy derived prediction of expected feedback. Thus, the results provide further insights about how speech motor output is controlled, as well as the computational role of auditory cortex in transforming auditory feedback. PMID:19523234

Relation between language experiences in preschool classrooms and children's kindergarten and fourth-grade language and reading abilities.

PubMed

Dickinson, David K; Porche, Michelle V

2011-01-01

Indirect effects of preschool classroom indexes of teacher talk were tested on fourth-grade outcomes for 57 students from low-income families in a longitudinal study of classroom and home influences on reading. Detailed observations and audiotaped teacher and child language data were coded to measure content and quantity of verbal interactions in preschool classrooms. Preschool teachers' use of sophisticated vocabulary during free play predicted fourth-grade reading comprehension and word recognition (mean age=9; 7), with effects mediated by kindergarten child language measures (mean age=5; 6). In large group preschool settings, teachers' attention-getting utterances were directly related to later comprehension. Preschool teachers' correcting utterances and analytic talk about books, and early support in the home for literacy predicted fourth-grade vocabulary, as mediated by kindergarten receptive vocabulary. © 2011 The Authors. Child Development © 2011 Society for Research in Child Development, Inc.

Effects on communicative requesting and speech development of the Picture Exchange Communication System in children with characteristics of autism.

PubMed

Ganz, Jennifer B; Simpson, Richard L

2004-08-01

Few studies on augmentative and alternative communication (AAC) systems have addressed the potential for such systems to impact word utterances in children with autism spectrum disorders (ASD). The Picture Exchange Communication System (PECS) is an AAC system designed specifically to minimize difficulties with communication skills experienced by individuals with ASD. The current study examined the role of PECS in improving the number of words spoken, increasing the complexity and length of phrases, and decreasing the non-word vocalizations of three young children with ASD and developmental delays (DD) with related characteristics. Participants were taught Phases 1-4 of PECS (i.e., picture exchange, increased distance, picture discrimination, and sentence construction). The results indicated that PECS was mastered rapidly by the participants and word utterances increased in number of words and complexity of grammar.

Expression of emotion in Eastern and Western music mirrors vocalization.

PubMed

Bowling, Daniel Liu; Sundararajan, Janani; Han, Shui'er; Purves, Dale

2012-01-01

In Western music, the major mode is typically used to convey excited, happy, bright or martial emotions, whereas the minor mode typically conveys subdued, sad or dark emotions. Recent studies indicate that the differences between these modes parallel differences between the prosodic and spectral characteristics of voiced speech sounds uttered in corresponding emotional states. Here we ask whether tonality and emotion are similarly linked in an Eastern musical tradition. The results show that the tonal relationships used to express positive/excited and negative/subdued emotions in classical South Indian music are much the same as those used in Western music. Moreover, tonal variations in the prosody of English and Tamil speech uttered in different emotional states are parallel to the tonal trends in music. These results are consistent with the hypothesis that the association between musical tonality and emotion is based on universal vocal characteristics of different affective states.

The stop voicing contrast in French: From citation speech to sentencial speech

NASA Astrophysics Data System (ADS)

Abdelli-Beruh, Nassima; Demaio, Eileen; Hisagi, Miwako

2004-05-01

This study explores the influence of speaking style on the salience of the acoustic correlates to the stop voicing distinction in French. Monolingual French speakers produced twenty-one C_vC_ syllables in citation speech, in minimal pairs and in sentence-length utterances (/pa/-/a/ context: /il a di pa C_vC_ a lui/; /pas/-/s/ context: /il a di pas C_vC_ sa~ lui/). Prominent stress was on the C_vC_. Voicing-related differences in percentages of closure voicing, durations of aspiration, closure, and vowel were analyzed as a function of these three speaking styles. Results show that the salience of the acoustic-phonetic segments present when the syllables are uttered in isolation or in minimal pairs is different than when the syllables are spoken in a sentence. These results are in agreement with findings in English.

A characterization of verb use in Turkish agrammatic narrative speech.

PubMed

Arslan, Seçkin; Bamyacı, Elif; Bastiaanse, Roelien

2016-01-01

This study investigates the characteristics of narrative-speech production and the use of verbs in Turkish agrammatic speakers (n = 10) compared to non-brain-damaged controls (n = 10). To elicit narrative-speech samples, personal interviews and storytelling tasks were conducted. Turkish has a large and regular verb inflection paradigm where verbs are inflected for evidentiality (i.e. direct versus indirect evidence available to the speaker). Particularly, we explored the general characteristics of the speech samples (e.g. utterance length) and the uses of lexical, finite and non-finite verbs and direct and indirect evidentials. The results show that speech rate is slow, verbs per utterance are lower than normal and the verb diversity is reduced in the agrammatic speakers. Verb inflection is relatively intact; however, a trade-off pattern between inflection for direct evidentials and verb diversity is found. The implications of the data are discussed in connection with narrative-speech production studies on other languages.

Children's perception of their synthetically corrected speech production.

PubMed

Strömbergsson, Sofia; Wengelin, Asa; House, David

2014-06-01

We explore children's perception of their own speech - in its online form, in its recorded form, and in synthetically modified forms. Children with phonological disorder (PD) and children with typical speech and language development (TD) performed tasks of evaluating accuracy of the different types of speech stimuli, either immediately after having produced the utterance or after a delay. In addition, they performed a task designed to assess their ability to detect synthetic modification. Both groups showed high performance in tasks involving evaluation of other children's speech, whereas in tasks of evaluating one's own speech, the children with PD were less accurate than their TD peers. The children with PD were less sensitive to misproductions in immediate conjunction with their production of an utterance, and more accurate after a delay. Within-category modification often passed undetected, indicating a satisfactory quality of the generated speech. Potential clinical benefits of using corrective re-synthesis are discussed.

Phrase frequency effects in language production.

PubMed

Janssen, Niels; Barber, Horacio A

2012-01-01

A classic debate in the psychology of language concerns the question of the grain-size of the linguistic information that is stored in memory. One view is that only morphologically simple forms are stored (e.g., 'car', 'red'), and that more complex forms of language such as multi-word phrases (e.g., 'red car') are generated on-line from the simple forms. In two experiments we tested this view. In Experiment 1, participants produced noun+adjective and noun+noun phrases that were elicited by experimental displays consisting of colored line drawings and two superimposed line drawings. In Experiment 2, participants produced noun+adjective and determiner+noun+adjective utterances elicited by colored line drawings. In both experiments, naming latencies decreased with increasing frequency of the multi-word phrase, and were unaffected by the frequency of the object name in the utterance. These results suggest that the language system is sensitive to the distribution of linguistic information at grain-sizes beyond individual words.

Recognizing intentions in infant-directed speech: evidence for universals.

PubMed

Bryant, Gregory A; Barrett, H Clark

2007-08-01

In all languages studied to date, distinct prosodic contours characterize different intention categories of infant-directed (ID) speech. This vocal behavior likely exists universally as a species-typical trait, but little research has examined whether listeners can accurately recognize intentions in ID speech using only vocal cues, without access to semantic information. We recorded native-English-speaking mothers producing four intention categories of utterances (prohibition, approval, comfort, and attention) as both ID and adult-directed (AD) speech, and we then presented the utterances to Shuar adults (South American hunter-horticulturalists). Shuar subjects were able to reliably distinguish ID from AD speech and were able to reliably recognize the intention categories in both types of speech, although performance was significantly better with ID speech. This is the first demonstration that adult listeners in an indigenous, nonindustrialized, and nonliterate culture can accurately infer intentions from both ID speech and AD speech in a language they do not speak.

Stuttering on function words in bilingual children who stutter: A preliminary study.

PubMed

Gkalitsiou, Zoi; Byrd, Courtney T; Bedore, Lisa M; Taliancich-Klinger, Casey L

2017-01-01

Evidence suggests young monolingual children who stutter (CWS) are more disfluent on function than content words, particularly when produced in the initial utterance position. The purpose of the present preliminary study was to investigate whether young bilingual CWS present with this same pattern. The narrative and conversational samples of four bilingual Spanish- and English-speaking CWS were analysed. All four bilingual participants produced significantly more stuttering on function words compared to content words, irrespective of their position in the utterance, in their Spanish narrative and conversational speech samples. Three of the four participants also demonstrated more stuttering on function compared to content words in their narrative speech samples in English, but only one participant produced more stuttering on function than content words in her English conversational sample. These preliminary findings are discussed relative to linguistic planning and language proficiency and their potential contribution to stuttered speech.

Paracetamol versus ibuprofen for the treatment of patent ductus arteriosus in preterm neonates: a meta-analysis of randomized controlled trials.

PubMed

Huang, Xintao; Wang, Fang; Wang, Kai

2018-08-01

Paracetamol has been suggested as an effective treatment for patent ductus arteriosus (PDA). However, the comparative efficacy and safety between paracetamol and ibuprofen were not determined. A meta-analysis of randomized controlled trials (RCTs) was performed. Relevant studies were identified via database searching. A fixed or random effect model was applied depending on the extent of heterogeneity. Five RCTs with 677 neonates were included. The efficacies for the primary (risk ratio [RR]: 1.03, p = .56) and overall PDA closure were comparable between the two medications (RR: 1.02, p = .62). Neonates of the two groups were comparable for the incidence of PDA complications, including necrotizing enterocolitis (RR: 0.86, p = .70), intraventricular hemorrhage (RR: 0.84, p = .55), bronchopulmonary dysplasia (RR: 0.69, p = .16), and retinopathy of prematurity (RR: 0.58, p = .15), and the risks of sepsis (RR = 0.88, p = .48) and death (RR: 1.45, p = .45) within hospitalization. However, treatment with paracetamol was associated with a trend of reduced risk of renal failure (RR: 0.20, p = .07), and a significantly reduced risk of gastrointestinal bleeding (RR: 0.28, p = .009). Paracetamol may confer comparable treatment efficacy for the closure of PDA as ibuprofen, although paracetamol is associated with lower risk of adverse events.

Effects of space allowance on the behaviour of long-term housed shelter dogs.

PubMed

Normando, Simona; Contiero, Barbara; Marchesini, Giorgio; Ricci, Rebecca

2014-03-01

The aim of this study was to assess the effects of space allowance (4.5 m(2)/head vs. 9 m(2)/head) on the behaviour of shelter dogs (Canis familiaris) at different times of the day (from 10:30 to 13:30 vs. from 14:30 to 17:30), and the dogs' preference between two types of beds (fabric bed vs. plastic basket). Twelve neutered dogs (seven males and five females aged 3-8 years) housed in pairs were observed using a scan sampling recording method every 20 s for a total of 14,592 scans/treatment. An increase in space allowance increased general level of activity (risk ratio (RR)=1.34), standing (RR=1.37), positive social interactions (RR=2.14), visual exploration of the environment (RR=1.21), and vocalisations (RR=2.35). Dogs spent more time in the sitting (RR=1.39) or standing (RR=1.88) posture, in positive interactions (RR=1.85), and active visual exploration (RR=1.99) during the morning than in the afternoon. The dogs were more often observed in the fabric bed than in the plastic basket (53% vs. 15% of total scans, p<0.001). Results suggest that a 9.0 m(2)/head space allowance could be more beneficial to dogs than one of 4.5 m(2). Copyright © 2014 Elsevier B.V. All rights reserved.

Marek’s Disease Virus Encoded Ribonucleotide Reductase Large Subunit is not Essential for In Vitro Replication

USDA-ARS?s Scientific Manuscript database

Marek’s disease virus (MDV) infected cells express a viral ribonucleotide reductase (RR) that is distinguishable from that present in uninfected cells by monoclonal antibody T81. Open reading frames UL39 and UL40 of the MDV genome encode the large (RR1) and small (RR2) subunits of RR enzyme, respe...

75 FR 63727 - Airworthiness Directives; Rolls-Royce plc (RR) RB211-524 Series Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... models that have not been repaired to RR Field Repair Scheme FRS5367/B, and A mandatory terminating... Repaired Using RR Field Repair Scheme FRS5367/B (h) If the combustion liner head section was previously repaired using RR Field Repair Scheme FRS5367/B, do the following: (1) Borescope-inspect combustion liner...

Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase.

PubMed

Huff, Sarah E; Mohammed, Faiz Ahmad; Yang, Mu; Agrawal, Prashansa; Pink, John; Harris, Michael E; Dealwis, Chris G; Viswanathan, Rajesh

2018-02-08

Ribonucleotide reductase (RR), an established cancer target, is usually inhibited by antimetabolites, which display multiple cross-reactive effects. Recently, we discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH or E-3a) of human RR (hRR) binding at the catalytic site (C-site) and inhibiting hRR reversibly. We herein report the synthesis and biochemical characterization of 25 distinct analogs. We designed each analog through docking to the C-site of hRR based on our 2.7 Å X-ray crystal structure (PDB ID: 5TUS). Broad tolerance to minor structural variations preserving inhibitory potency is observed. E-3f (82% yield) displayed an in vitro IC 50 of 5.3 ± 1.8 μM against hRR, making it the most potent in this series. Kinetic assays reveal that E-3a, E-3c, E-3t, and E-3w bind and inhibit hRR through a reversible and competitive mode. Target selectivity toward the R1 subunit of hRR is established, providing a novel way of inhibition of this crucial enzyme.

Iterative Structural and Functional Synergistic Resolution Recovery (iSFS-RR) Applied to PET-MR Images in Epilepsy

NASA Astrophysics Data System (ADS)

Silva-Rodríguez, J.; Cortés, J.; Rodríguez-Osorio, X.; López-Urdaneta, J.; Pardo-Montero, J.; Aguiar, P.; Tsoumpas, C.

2016-10-01

Structural Functional Synergistic Resolution Recovery (SFS-RR) is a technique that uses supplementary structural information from MR or CT to improve the spatial resolution of PET or SPECT images. This wavelet-based method may have a potential impact on the clinical decision-making of brain focal disorders such as refractory epilepsy, since it can produce images with better quantitative accuracy and enhanced detectability. In this work, a method for the iterative application of SFS-RR (iSFS-RR) was firstly developed and optimized in terms of convergence and input voxel size, and the corrected images were used for the diagnosis of 18 patients with refractory epilepsy. To this end, PET/MR images were clinically evaluated through visual inspection, atlas-based asymmetry indices (AIs) and SPM (Statistical Parametric Mapping) analysis, using uncorrected images and images corrected with SFS-RR and iSFS-RR. Our results showed that the sensitivity can be increased from 78% for uncorrected images, to 84% for SFS-RR and 94% for the proposed iSFS-RR. Thus, the proposed methodology has demonstrated the potential to improve the management of refractory epilepsy patients in the clinical routine.

Employee well-being and sick leave, occupational accident, and disability pension: a cohort study of civil servants.

PubMed

Kuoppala, Jaana; Lamminpää, Anne; Väänänen-Tomppo, Irma; Hinkka, Katariina

2011-06-01

To study the association between employee well-being and sick leave, occupational accident, and disability pension. A random population of 967 civil servants participated in a survey on psychosocial factors and health at work in 2000 in Finland. The median follow-up time was 7.3 years. The risks of sick leave and disability pension were decreased by job satisfaction (RR = 0.78, 95% CI = 0.58 to 1.05; RR = 0.47, CI = 0.20 to 1.06; respectively), good work ability (RR = 0.35, CI = 0.22 to 0.56; RR = 0.11, CI = 0.04 to 0.33), good health (RR = 0.42, CI = 0.27 to 0.64; RR = 0.32, CI = 0.11 to 0.98), and strong sense of coherence (RR = 0.53, CI = 0.36 to 0.79; RR = 0.17, CI = 0.07 to 0.37). Employee well-being was also associated with occupational accident but somewhat less consistently. Employee well-being is associated with sick leave, occupational accident, and disability pension. It is important to find means to support employee well-being both in general and at work.

In Situ Hybridization Method Reveals (Pro)renin Receptor Expressing Cells in the Pituitary Gland of Rats: Correlation with Anterior Pituitary Hormones.

PubMed

Takahashi, Kazuhiro; Yatabe, Megumi; Fujiwara, Ken; Hirose, Takuo; Totsune, Kazuhito; Yashiro, Takashi

2013-02-28

Expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, was studied in rat pituitary gland. In situ hybridization showed that cells expressing (P)RR mRNA were widely distributed in the anterior lobe and intermediate lobe of the pituitary gland. Double-staining using in situ hybridization for (P)RR mRNA and immunohistochemistry for the pituitary hormones showed that (P)RR mRNA was expressed in most of the GH cells and ACTH cells in the anterior lobe. (P)RR mRNA was also expressed in a few prolactin cells and TSH cells, but not in LH cells. The present study has shown for the first time the distribution of (P)RR mRNA expressing cells in the rat pituitary gland. These findings suggest that (P)RR plays physiological roles in the pituitary gland, such as the modulation of the pituitary hormone secretion.

Transcriptional Changes That Characterize the Immune Reactions of Leprosy

PubMed Central

Dupnik, Kathryn M.; Bair, Thomas B.; Maia, Andressa O.; Amorim, Francianne M.; Costa, Marcos R.; Keesen, Tatjana S. L.; Valverde, Joanna G.; Queiroz, Maria do Carmo A. P.; Medeiros, Lúcio L.; de Lucena, Nelly L.; Wilson, Mary E.; Nobre, Mauricio L.; Johnson, Warren D.; Jeronimo, Selma M. B.

2015-01-01

Background. Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL). Methods. To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry. Results. There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the “complement and coagulation” pathway common to both. Interferon γ was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL. Conclusions. These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis. PMID:25398459

Optical pathology study of human abdominal aorta tissues using confocal micro resonance Raman spectroscopy

NASA Astrophysics Data System (ADS)

Liu, Cheng-hui; Boydston-White, Susie; Wang, Wubao; Sordillo, Laura A.; Shi, Lingyan; Weisberg, Arel; Tomaselli, Vincent P.; Sordillo, Peter P.; Alfano, Robert R.

2016-03-01

Resonance Raman (RR) spectroscopic technique has a high potential for label-free and in-situ detection of biomedical lesions in vivo. This study evaluates the ability of RR spectroscopy method as an optical histopathology tool to detect the atherosclerotic plaque states of abdominal aorta in vitro. This part demonstrates the RR spectral molecular fingerprint features from different sites of the atherosclerotic abdominal aortic wall tissues. Total 57 sites of five pieces aortic samples in intimal and adventitial wall from an autopsy specimen were examined using confocal micro Raman system of WITec 300R with excitation wavelength of 532nm. The preliminary RR spectral biomarkers of molecular fingerprints indicated that typical calcified atherosclerotic plaque (RR peak at 964cm-1) tissue; fibrolipid plaque (RR peaks at 1007, 1161, 1517 and 2888cm-1) tissue, lipid pool with the fatty precipitation cholesterol) with collagen type I (RR peaks at 864, 1452, 1658, 2888 and 2948cm-1) in the soft tissue were observed and investigated.

The redeployment of attention to the mouth of a talking face during the second year of life.

PubMed

Hillairet de Boisferon, Anne; Tift, Amy H; Minar, Nicholas J; Lewkowicz, David J

2018-08-01

Previous studies have found that when monolingual infants are exposed to a talking face speaking in a native language, 8- and 10-month-olds attend more to the talker's mouth, whereas 12-month-olds no longer do so. It has been hypothesized that the attentional focus on the talker's mouth at 8 and 10 months of age reflects reliance on the highly salient audiovisual (AV) speech cues for the acquisition of basic speech forms and that the subsequent decline of attention to the mouth by 12 months of age reflects the emergence of basic native speech expertise. Here, we investigated whether infants may redeploy their attention to the mouth once they fully enter the word-learning phase. To test this possibility, we recorded eye gaze in monolingual English-learning 14- and 18-month-olds while they saw and heard a talker producing an English or Spanish utterance in either an infant-directed (ID) or adult-directed (AD) manner. Results indicated that the 14-month-olds attended more to the talker's mouth than to the eyes when exposed to the ID utterance and that the 18-month-olds attended more to the talker's mouth when exposed to the ID and the AD utterance. These results show that infants redeploy their attention to a talker's mouth when they enter the word acquisition phase and suggest that infants rely on the greater perceptual salience of redundant AV speech cues to acquire their lexicon. Copyright © 2018 Elsevier Inc. All rights reserved.

Behind closed doors: systematic analysis of breast cancer consultation communication and predictors of satisfaction with communication.

PubMed

Hack, Thomas F; Pickles, Tom; Ruether, J Dean; Weir, Lorna; Bultz, Barry D; Degner, Lesley F

2010-06-01

The purpose of this investigation was to explicate the content of primary adjuvant treatment consultations in breast oncology and examine the predictive relationships between patient and oncologist consultation factors and patient satisfaction with communication. The recorded consultations of 172 newly diagnosed breast cancer patients from four Canadian cancer centers were randomly drawn from a larger subset of 481 recordings and examined by three coders using the Medical Interaction Process System (MIPS); a system that categorizes the content and mode of each distinct utterance. The MIPS findings, independent observer ratings of patient and oncologist affective behavior, and derived consultation ratios of patient centeredness, patient directedness, and psychosocial focus, were used to predict patient satisfaction with communication post-consultation and at 12-weeks post-consultation. Biomedical content categories were predominant in the consultations, accounting for 88% of all utterances, followed by administrative (6%) and psychosocial (6%) utterances. Post-consultation satisfaction with communication was significantly higher for older patients, those with smaller primary tumors and those with longer consultations. Smaller tumor, lack of patient assertiveness during the treatment consultation and having the consultation with a radiation rather than medical oncologist were significantly predictive of greater satisfaction at 12-weeks post-consultation. Adjuvant treatment consultations are characterized by a high degree of information-giving by the physician, a predominance of biomedical discussion and relatively minimal time addressing patients' psychosocial concerns. Controlled trials are needed to further identify and address the contextual features of these consultations that enhance patient satisfaction. (c) 2009 John Wiley & Sons, Ltd.

Intra-oral pressure-based voicing control of electrolaryngeal speech with intra-oral vibrator.

PubMed

Takahashi, Hirokazu; Nakao, Masayuki; Kikuchi, Yataro; Kaga, Kimitaka

2008-07-01

In normal speech, coordinated activities of intrinsic laryngeal muscles suspend a glottal sound at utterance of voiceless consonants, automatically realizing a voicing control. In electrolaryngeal speech, however, the lack of voicing control is one of the causes of unclear voice, voiceless consonants tending to be misheard as the corresponding voiced consonants. In the present work, we developed an intra-oral vibrator with an intra-oral pressure sensor that detected utterance of voiceless phonemes during the intra-oral electrolaryngeal speech, and demonstrated that an intra-oral pressure-based voicing control could improve the intelligibility of the speech. The test voices were obtained from one electrolaryngeal speaker and one normal speaker. We first investigated on the speech analysis software how a voice onset time (VOT) and first formant (F1) transition of the test consonant-vowel syllables contributed to voiceless/voiced contrasts, and developed an adequate voicing control strategy. We then compared the intelligibility of consonant-vowel syllables among the intra-oral electrolaryngeal speech with and without online voicing control. The increase of intra-oral pressure, typically with a peak ranging from 10 to 50 gf/cm2, could reliably identify utterance of voiceless consonants. The speech analysis and intelligibility test then demonstrated that a short VOT caused the misidentification of the voiced consonants due to a clear F1 transition. Finally, taking these results together, the online voicing control, which suspended the prosthetic tone while the intra-oral pressure exceeded 2.5 gf/cm2 and during the 35 milliseconds that followed, proved efficient to improve the voiceless/voiced contrast.

Effects of Visual Speech on Early Auditory Evoked Fields - From the Viewpoint of Individual Variance.

PubMed

Yahata, Izumi; Kawase, Tetsuaki; Kanno, Akitake; Hidaka, Hiroshi; Sakamoto, Shuichi; Nakasato, Nobukazu; Kawashima, Ryuta; Katori, Yukio

2017-01-01

The effects of visual speech (the moving image of the speaker's face uttering speech sound) on early auditory evoked fields (AEFs) were examined using a helmet-shaped magnetoencephalography system in 12 healthy volunteers (9 males, mean age 35.5 years). AEFs (N100m) in response to the monosyllabic sound /be/ were recorded and analyzed under three different visual stimulus conditions, the moving image of the same speaker's face uttering /be/ (congruent visual stimuli) or uttering /ge/ (incongruent visual stimuli), and visual noise (still image processed from speaker's face using a strong Gaussian filter: control condition). On average, latency of N100m was significantly shortened in the bilateral hemispheres for both congruent and incongruent auditory/visual (A/V) stimuli, compared to the control A/V condition. However, the degree of N100m shortening was not significantly different between the congruent and incongruent A/V conditions, despite the significant differences in psychophysical responses between these two A/V conditions. Moreover, analysis of the magnitudes of these visual effects on AEFs in individuals showed that the lip-reading effects on AEFs tended to be well correlated between the two different audio-visual conditions (congruent vs. incongruent visual stimuli) in the bilateral hemispheres but were not significantly correlated between right and left hemisphere. On the other hand, no significant correlation was observed between the magnitudes of visual speech effects and psychophysical responses. These results may indicate that the auditory-visual interaction observed on the N100m is a fundamental process which does not depend on the congruency of the visual information.

Seeing Emotion with Your Ears: Emotional Prosody Implicitly Guides Visual Attention to Faces

PubMed Central

Rigoulot, Simon; Pell, Marc D.

2012-01-01

Interpersonal communication involves the processing of multimodal emotional cues, particularly facial expressions (visual modality) and emotional speech prosody (auditory modality) which can interact during information processing. Here, we investigated whether the implicit processing of emotional prosody systematically influences gaze behavior to facial expressions of emotion. We analyzed the eye movements of 31 participants as they scanned a visual array of four emotional faces portraying fear, anger, happiness, and neutrality, while listening to an emotionally-inflected pseudo-utterance (Someone migged the pazing) uttered in a congruent or incongruent tone. Participants heard the emotional utterance during the first 1250 milliseconds of a five-second visual array and then performed an immediate recall decision about the face they had just seen. The frequency and duration of first saccades and of total looks in three temporal windows ([0–1250 ms], [1250–2500 ms], [2500–5000 ms]) were analyzed according to the emotional content of faces and voices. Results showed that participants looked longer and more frequently at faces that matched the prosody in all three time windows (emotion congruency effect), although this effect was often emotion-specific (with greatest effects for fear). Effects of prosody on visual attention to faces persisted over time and could be detected long after the auditory information was no longer present. These data imply that emotional prosody is processed automatically during communication and that these cues play a critical role in how humans respond to related visual cues in the environment, such as facial expressions. PMID:22303454

[Ventriloquism and audio-visual integration of voice and face].

PubMed

Yokosawa, Kazuhiko; Kanaya, Shoko

2012-07-01

Presenting synchronous auditory and visual stimuli in separate locations creates the illusion that the sound originates from the direction of the visual stimulus. Participants' auditory localization bias, called the ventriloquism effect, has revealed factors affecting the perceptual integration of audio-visual stimuli. However, many studies on audio-visual processes have focused on performance in simplified experimental situations, with a single stimulus in each sensory modality. These results cannot necessarily explain our perceptual behavior in natural scenes, where various signals exist within a single sensory modality. In the present study we report the contributions of a cognitive factor, that is, the audio-visual congruency of speech, although this factor has often been underestimated in previous ventriloquism research. Thus, we investigated the contribution of speech congruency on the ventriloquism effect using a spoken utterance and two videos of a talking face. The salience of facial movements was also manipulated. As a result, when bilateral visual stimuli are presented in synchrony with a single voice, cross-modal speech congruency was found to have a significant impact on the ventriloquism effect. This result also indicated that more salient visual utterances attracted participants' auditory localization. The congruent pairing of audio-visual utterances elicited greater localization bias than did incongruent pairing, whereas previous studies have reported little dependency on the reality of stimuli in ventriloquism. Moreover, audio-visual illusory congruency, owing to the McGurk effect, caused substantial visual interference to auditory localization. This suggests that a greater flexibility in responding to multi-sensory environments exists than has been previously considered.

Effects of Air Pollutant Exposure on Acute Myocardial Infarction, According to Gender.

PubMed

Tuan, Tássia Soldi; Venâncio, Taís Siqueira; Nascimento, Luiz Fernando Costa

2016-09-01

There is evidence of the effects of air pollution on hospital admissions due to cardiovascular diseases, including myocardial infarction. To estimate the association between exposure to air pollutants and hospital admissions due to myocardial infarction according to gender, between January 1st 2012 and December 31st 2013, in São Jose dos Campos-SP. An ecological time series study was carried out with daily data of admissions due to AMI, pollutants CO, O3, PM10, SO2, and NO2, according to gender. We used the Poisson regression generalized linear model to estimate the relative risks of hospital admissions with lags of 0-5 days, adjusted for temperature, humidity, seasonality and days of the week. There were 1837 admissions for ischemic heart diseases, with 636 women and 1201 men. For females, the risks were significant for CO in lag 0 (RR = 1,09), lag1 (RR = 1,08) and lag 5 (RR = 1,10) and SO2 in lag 0 (RR = 1,10) and 3 (RR = 1,09). For men there was significance of the CO in, lag 3 and lag 5 (RR = 1,05). There was significance, regardless of gender, for CO at lag 1 (RR = 1,05) and lag 5 (RR = 1,07) and lag 0 for SO2 (RR = 1,06). The data presented show the important role of CO and SO2 in the genesis of myocardial infarction admissions, and responses to pollutant exposure are different if analyzed by gender and together - hence the importance of a stratified analyses. Existem evidências sobre os efeitos da poluição do ar nas internações por doenças cardiovasculares, entre elas o infarto do miocárdio. Estimar a associação entre exposição a poluentes do ar e internações por infarto segundo gêneros, entre 01 de Janeiro de 2012 e 31 de Dezembro de 2013, em São José dos Campos - SP. Estudo ecológico de série temporal com dados diários de internações por IAM dos poluentes CO, O3, PM10, SO2, NO2, segundo gêneros. Utilizou-se modelo linear generalizado da Regressão de Poisson para estimar os riscos relativos para internações com defasagens de 0 a 5 dias, ajustados por temperatura, umidade, sazonalidade e dias da semana. Foram 1837 internações por doenças isquêmicas do coração, sendo 636 mulheres e 1201 homens. Para o gênero feminino, os riscos foram significativos para o CO nos lag 0 (RR = 1,09), lag1 (RR = 1,08) e lag 5 (RR = 1,10) e para o SO2 no lag 0 (RR = 1,10) e 3 (RR = 1,09). Para o gênero masculino houve significância para o CO no lag 3 e lag 5 (RR = 1,05). Sem distinção de gênero houve significância para o CO no lag 1 (RR = 1,05) e lag 5 (RR = 1,07) e no lag 0 para o SO2 (RR = 1,06). Os dados apresentados mostram o importante papel do CO e do SO2 na gênese das internações por infarto e que as respostas à exposição aos poluentes são diferentes se analisadas por sexo e em conjunto, daí a importância de se estratificarem as análises.

Left ventricular hypertrophy assessed by electrocardiogram is associated with more severe stroke and with higher in-hospital mortality in patients with acute ischemic stroke.

PubMed

Tziomalos, Konstantinos; Sofogianni, Areti; Angelopoulou, Stella-Maria; Christou, Konstantinos; Kostaki, Stavroula; Papagianni, Marianthi; Satsoglou, Sarantis; Spanou, Marianna; Savopoulos, Christos; Hatzitolios, Apostolos I

2018-07-01

Left ventricular hypertrophy (LVH), assessed by electrocardiogram (ECG), is associated with increased risk for stroke. However, few studies that evaluated whether ECG-detected LVH predicts ischemic stroke severity and outcome. We aimed to evaluate these associations. We prospectively studied 922 patients consecutively admitted with acute ischemic stroke (age 79.6 ± 6.9 years). Stroke severity was assessed at admission with the National Institutes of Health Stroke Scale (NIHSS). Severe stroke was defined as NIHSS≥5. LVH was evaluated with the Sokolow-Lyon index and the Cornell voltage-duration product criteria in an ECG obtained at admission. The outcome was assessed with dependency at discharge (modified Rankin scale 2-5) and in-hospital mortality. Independent predictors of severe stroke were age (relative risk (RR) per year 1.07, 95% confidence interval (CI) 1.03-1.11, p<0.001), female gender (RR 0.36, 95% CI 0.17-0.76, p<0.01), atrial fibrillation (RR 2.07, 95% CI 1.30-3.29, p<0.005), chronic kidney disease (RR 2.38, 95% CI 1.04-5.44, p<0.05), heart rate (RR per 1/min 1.02, 95% CI 1.01-1.04, p<0.005), glucose levels (RR 1.012, 95% CI 1.006-1.018, p<0.001), high-density lipoprotein cholesterol levels (RR 0.976, 95% CI 0.960-0.993, p<0.005) and LVH defined according to the Cornell voltage-duration product criteria (RR 2.08, 95% CI 1.12-3.86, p<0.05). Independent predictors of dependency at discharge were age (RR per year 1.08, 95% CI 1.03-1.13, p<0.001), past smoking (RR versus no smoking 0.42, 95% 0.19-0.89, p<0.05), history of ischemic stroke (RR 2.13, 95% CI 1.23-3.71, p<0.01) and NIHSS at admission (RR 1.48, 95% CI 1.35-1.63, p<0.001). Independent predictors of in-hospital mortality were glucose levels (RR 1.014, 95% CI 1.003-1.025, p<0.05), NIHSS at admission (RR 1.29, 95% CI 1.19-1.41, p<0.001) and LVH according to the Cornell voltage-duration product criteria (RR 4.95, 95% CI 1.09-22.37, p<0.05). LVH according to the Cornell voltage-duration product criteria appears to be associated with more severe stroke and with higher in-hospital mortality in patients with acute ischemic stroke. Copyright © 2018 Elsevier B.V. All rights reserved.

Improving Teacher Communications: Focus on Clarity and Questioning Skills.

ERIC Educational Resources Information Center

Harris, Paulette P.; Swick, Kevin J.

1985-01-01

Reviews the literature on teacher clarity and communication skills, then describes a study showing that teachers must be trained in ways to reduce vagueness terms, mazes, multiple utterance questions, and overall frequency of questions posed to students. (FL)

Teaching Sentential Intonation through Proverbs

ERIC Educational Resources Information Center

Yurtbasi, Metin

2012-01-01

Suprasegmental elements such as "stress," "pitch," "juncture" and "linkers" are language universals that are uttered naturally in the mother tongue without prior training but need to be learned systematically in the target language. Among other techniques of "sentential pronunciation teaching" to…

Sex differences in injury during top-level international athletics championships: surveillance data from 14 championships between 2007 and 2014.

PubMed

Edouard, Pascal; Feddermann-Demont, Nina; Alonso, Juan Manuel; Branco, Pedro; Junge, Astrid

2015-04-01

Injury incidence has been reported for international athletics championships from 2007 to 2012. However, it is unclear whether male or female athletes differ in risk and/or characteristics of injuries. To compare the incidences and characteristics of injuries that occurred during international athletics championships between female and male athletes. The national medical team and the local organising committee physicians reported all injuries daily on a standardised injury report form during 14 international championships from 2007 to 2014. Relative risks (RR) of injury, 95% CI and magnitude thresholds were calculated. The rate of injuries per 1000 registered athletes was significantly higher in male (110.3±6.8) than in female (88.5±6.7) athletes (RR=1.25; 95% CI 1.13 to 1.37, small effect size). Male athletes incurred significantly more injuries in the thigh (RR=1.64; 95% CI 1.32 to 2.05, small), lower leg (RR=1.36; 95% CI 1.05 to 1.75, small) and hip/groin injuries (RR=2.26; 95% CI 1.31 to 3.88, moderate), more muscle strains (RR=1.64; 95% CI 1.33 to 2.04, small), cramps (RR=1.81; 95% CI 1.35 to 2.43, small), and especially more thigh strains (RR=1.66; 95% CI 1.25 to 2.19, small), but fewer stress fractures (RR=0.32; 95% CI 0.12 to 0.81, moderate) than female athletes. A higher injury risk of male than of female athletes was observed in sprints (RR=1.32; 95% CI 1.06 to 1.66, small), middle distance runs (RR=1.48; 95% CI 1.06 to 2.06, small), race walks (RR=2.55; 95% CI 1.27 to 5.10, moderate) and jumps (RR=2.13; 95% CI 1.53 to 2.97, moderate). No sex difference was found for cause and severity of injury. Injury risk during international athletics championships differed between female and male athletes for location, type and event groups. Injury prevention strategies should be sex-specific, regarding the differences in injury location and type. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Financial exploitation of older adults: a population-based prevalence study.

PubMed

Peterson, Janey C; Burnes, David P R; Caccamise, Paul L; Mason, Art; Henderson, Charles R; Wells, Martin T; Berman, Jacquelin; Cook, Ann Marie; Shukoff, Denise; Brownell, Patricia; Powell, Mebane; Salamone, Aurora; Pillemer, Karl A; Lachs, Mark S

2014-12-01

Financial exploitation is the most common and least studied form of elder abuse. Previous research estimating the prevalence of financial exploitation of older adults (FEOA) is limited by a broader emphasis on traditional forms of elder mistreatment (e.g., physical, sexual, emotional abuse/neglect). 1) estimate the one-year period prevalence and lifetime prevalence of FEOA; 2) describe major FEOA types; and 3) identify factors associated with FEOA. Prevalence study with a random, stratified probability sample. Four thousand, one hundred and fifty-six community-dwelling, cognitively intact adults age ≥ 60 years. New York State. Comprehensive tool developed for this study measured five FEOA domains: 1) stolen or misappropriated money/property; 2) coercion resulting in surrendering rights/property; 3) impersonation to obtain property/services; 4) inadequate contributions toward household expenses, but respondent still had enough money for necessities and 5) respondent was destitute and did not receive necessary assistance from family/friends. One-year period FEOA prevalence was 2.7% (95% CI, 2.29-3.29) and lifetime prevalence was 4.7% (95% CI, 4.05-5.34). Greater relative risk (RR) of one-year period prevalence was associated with African American/black race (RR, 3.80; 95 % CI, 1.11-13.04), poverty (RR, 1.72; 95 % CI, 1.09-2.71), increasing number of non-spousal household members (RR, 1.16; 95 % CI, 1.06-1.27), and ≥ 1 instrumental activity of daily living (IADL) impairments (RR, 1.69; 95 % CI, 1.12-2.53). Greater RR of lifetime prevalence was associated with African American/black race (RR, 2.61; 95 % CI, 1.37-4.98), poverty (RR, 1.47; 95 % CI, 1.04-2.09), increasing number of non-spousal household members (RR, 1.16; 95 % CI, 1.12-1.21), and having ≥1 IADL (RR, 1.45; 95 % CI, 1.11-1.90) or ≥1 ADL (RR, 1.52; 95 % CI, 1.06-2.18) impairment. Living with a spouse/partner was associated with a significantly lower RR of lifetime prevalence (RR, 0.39; 95 % CI, 0.26-0.59) CONCLUSIONS: Financial exploitation of older adults is a common and serious problem. Elders from groups traditionally considered to be economically, medically, and sociodemographically vulnerable are more likely to self-report financial exploitation.

Can Comprehensive Chromosome Screening Technology Improve IVF/ICSI Outcomes? A Meta-Analysis

PubMed Central

Quan, Song

2015-01-01

Objective To examine whether comprehensive chromosome screening (CCS) for preimplantation genetic screening (PGS) has an effect on improving in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes compared to traditional morphological methods. Methods A literature search was conducted in PubMed, EMBASE, CNKI and ClinicalTrials.gov up to May 2015. Two reviewers independently evaluated titles and abstracts, extracted data and assessed quality. We included studies that compared the IVF/ICSI outcomes of CCS-based embryo selection with those of the traditional morphological method. Relative risk (RR) values with corresponding 95% confidence intervals (CIs) were calculated in RevMan 5.3, and subgroup analysis and Begg’s test were used to assess heterogeneity and potential publication bias, respectively. Results Four RCTs and seven cohort studies were included. A meta-analysis of the outcomes showed that compared to morphological criteria, euploid embryos identified by CCS were more likely to be successfully implanted (RCT RR 1.32, 95% CI 1.18–1.47; cohort study RR 1.74, 95% CI 1.35–2.24). CCS-based PGS was also related to an increased clinical pregnancy rate (RCT RR 1.26, 95% CI 0.83–1.93; cohort study RR 1.48, 95% CI 1.20–1.83), an increased ongoing pregnancy rate (RCT RR 1.31, 95% CI 0.64–2.66; cohort study RR 1.61, 95% CI 1.30–2.00), and an increased live birth rate (RCT RR 1.26, 95% CI 1.05–1.50; cohort study RR 1.35, 95% CI 0.85–2.13) as well as a decreased miscarriage rate (RCT RR 0.53, 95% CI 0.24–1.15; cohort study RR 0.31, 95% CI 0.21–0.46) and a decreased multiple pregnancy rate (RCT RR 0.02, 95% CI 0.00–0.26; cohort study RR 0.19, 95% CI 0.07–0.51). The results of the subgroup analysis also showed a significantly increased implantation rate in the CCS group. Conclusions The effectiveness of CCS-based PGS is comparable to that of traditional morphological methods, with better outcomes for women receiving IVF/ICSI technology. The transfer of both trophectoderm-biopsied and blastomere-biopsied CCS-euploid embryos can improve the implantation rate. PMID:26470028

Safety of Tenofovir Disoproxil Fumarate–Based Antiretroviral Therapy Regimens in Pregnancy for HIV-Infected Women and Their Infants: A Systematic Review and Meta-Analysis

PubMed Central

Uthman, Olalekan A.; Mofenson, Lynne M.; Anderson, Jean R.; Kanters, Steve; Renaud, Francoise; Ford, Nathan; Essajee, Shaffiq; Doherty, Meg C.; Mills, Edward J.

2017-01-01

Background: There are limited data on adverse effects of tenofovir disoproxil fumarate (TDF)-based antiretroviral therapy (ART) on pregnant women and their infants. Methods: We conducted a systematic review of studies published between January 1980 and January 2017 that compared adverse outcomes in HIV-infected women receiving TDF- vs. non–TDF-based ART during pregnancy. The risk ratio (RR) for associations was pooled using a fixed-effects model. Results: Seventeen studies met the study inclusion criteria. We found that the rate of preterm (<37 weeks gestation) delivery (RR = 0.90, 95% confidence interval [CI]: 0.81 to 0.99, I2 = 59%) and stillbirth (RR = 0.60, 95% CI: 0.43 to 0.84, I2 = 72.0%) were significantly lower in women exposed (vs. not) to TDF-based ART regimen. We found no increased risk in maternal severe (grade 3) or potentially life-threatening (grade 4) adverse events (RR = 0.62; 95% CI: 0.30 to 1.29), miscarriage (RR = 1.09; 95% CI: 0.80 to 1.48), very preterm (<34 weeks gestation) delivery (RR = 1.08, 95% CI: 0.72 to 1.62), small for gestational age (RR = 0.87, 95% CI: 0.67 to 1.13), low birth weight (RR = 0.91; 95% CI: 0.80 to 1.04), very low birth weight (RR = 3.18; 95% CI: 0.65 to 15.63), congenital anomalies (RR = 1.03; 95% CI: 0.83 to 1.28), infant adverse outcomes or infant mortality (age >14 days) (RR = 0.65; 95% CI: 0.23 to 1.85), but increased neonatal mortality (age <14 days) risk (RR = 5.64, 95% CI: 1.70 to 18.79) with TDR-based ART exposure. No differences were found for anthropomorphic parameters at birth; one study reported minor differences in z-scores for length and head circumference at age 1 year. Conclusions: TDF-based ART in pregnancy seems generally safe for women and their infants. However, data remain limited and further studies are needed, particularly to assess neonatal mortality and infant growth/bone effects. PMID:28291053

Risk of immune-related colitis with PD-1/PD-L1 inhibitors vs chemotherapy in solid tumors: systems assessment.

PubMed

Su, Qiang; Zhang, Xiaochen; Shen, Xinhua; Hou, Yanli; Sun, Zhigang; Gao, Zu Hua

2018-01-01

Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomized controlled trials (RCTs) with PD-1/PD-L1 inhibitors. The data was analyzed by Stata version 12.0 software. Results: After exclusion of ineligible studies, 11 clinical trials were considered eligible for the meta-analysis, including 5751 patients. Compared with chemotherapy, the risk ratios (RRs) of all-grade colitis were significant for the PD-1 inhibitor subgroup (RR 2.69, 95% confidence interval (CI): 1.15-6.29, p=0.023), and for pembrolizumab subgroup (RR 3.17, 95% CI: 1.08-9.37, p=0.037), but not for nivolumab treatment and PD-L1 inhibitor (atezolizumab) treatment (RR 2.05, 95% CI: 0.52-8.13, p=0.305; RR 4.75,95% CI: 0.56-40.50, p=0.154, respectively). The RR of all-grade colitis was significant for PD-1/PD-L1 inhibitor in NSCLC (RR 4.34, 95% CI: 1.37-13.82, p=0.013), and not significant in melanoma (RR 2.11, 95% CI: 0.54-8.34, p=0.285). Moreover, the RRs of all-grade diarrhea were significant for the PD-1 inhibitor subgroup (RR 0.61, 95% CI: 0.44-0.83, p=0.002), for the nivolumab subgroup (RR 0.54, 95% CI: 0.34-0.87, p=0.012), and for atezolizumab subgroup (RR 0.48, 95% CI: 0.25-0.89, p=0.021). The RR of high-grade diarrhea was significant for atezolizumab subgroup (RR 0.34, 95% CI: 0.12-0.94, p=0.037). Conclusions: Our meta-analysis demonstrates that compared with chemotherapy, pembrolizumab may result in a higher risk of all-grade immune-mediated colitis. PD-1/PD-L1 inhibitor treatment in NSCLC patients, but not in melanoma patients, increases the risk of all-grade colitis incidence.

Low gestational weight gain and the risk of preterm birth and low birthweight: a systematic review and meta-analyses.

PubMed

Han, Zhen; Lutsiv, Olha; Mulla, Sohail; Rosen, Allison; Beyene, Joseph; McDonald, Sarah D

2011-09-01

Low gestational weight gain is common, with potential adverse perinatal outcomes. To determine the relation between low gestational weight gain and preterm birth and low birthweight in singletons in developing and developed countries. Medline, EMBASE and reference lists were searched, identifying 6,283 titles and abstracts. Following the MOOSE consensus statement, two assessors independently reviewed titles, abstracts, full articles, extracted data and assessed quality. Fifty-five studies, 37 cohort and 18 case-control, were included, involving 3,467,638 women. In the cohort studies (crude data, generally supported where available by adjusted data and case-control studies), women with low total gestational weight gain had increases in preterm birth <37 weeks [RR 1.64 (95%CI 1.62-1.65)], 32-36 weeks [RR 1.39 (95%CI 1.38-1.40)] and ≤ 32 weeks [RR 3.80 (95%CI 3.72-3.88)]. Low total gestational weight gain was associated with increased risks of low birthweight <2,500 g [RR 1.85 (95%CI 1.72-2.00)], in developing and developed countries [RR 1.84 (95%CI 1.71-1.99) and RR 3.02 (95%CI 1.37-6.63), respectively], 1,500-2,500 g [RR 2.02 (95%CI 1.88-2.17)] and <1,500 g (RR 2.00 (95%CI 1.67-2.40)]. Women with low weekly gestational weight gain were at increased risk of preterm birth [RR 1.56 (95%CI 1.26-1.94)], 32-36 weeks [RR 2.43 (95%CI 2.37-2.50)] and ≤ 32 weeks [RR 2.31 (95%CI 2.20-2.42)] but not low birthweight [RR 1.64 (95%CI 0.89-3.02)]. In this systematic review, we determined that singletons born to women with low total gestational weight gain have higher risks of preterm birth and low birthweight, with the lower the gain, the higher the risks. © 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.

Use of an electronic medical record improves the quality of urban pediatric primary care.

PubMed

Adams, William G; Mann, Adriana M; Bauchner, Howard

2003-03-01

To evaluate the quality of pediatric primary care, including preventive services, before and after the introduction of an electronic medical record (EMR) developed for use in an urban pediatric primary care center. A pre-postintervention analysis was used in the study. The intervention was a pediatric EMR. Routine health care maintenance visits for children <5 years old were reviewed, and documentation during preintervention (paper-based, 1998) and postintervention visits (computer-based, 2000) was compared. A total of 235 paper-based visits and 986 computer-based visits met study criteria. Twelve clinicians (all attendings or nurse practitioners) contributed an average of 19.4 paper-based visits (range: 5-39) and 7 of these clinicians contributed an average of 141 computer-based visits each (range: 61-213). Computer-based clinicians were significantly more likely to address a variety of routine health care maintenance topics including: diet (relative risk [RR]: 1.09), sleep (RR: 1.46), at least 1 psychosocial issue (RR: 1.42), smoking in the home (RR: 15.68), lead risk assessment (RR: 106.54), exposure to domestic or community violence (RR: 35.19), guns in the home (RR: 58.11), behavioral or social developmental milestones (RR: 2.49), infant sleep position (RR: 9.29), breastfeeding (RR: 1.99), poison control (RR: 3.82), and child safety (RR: 1.29). Trends toward improved lead exposure, vision, and hearing screening were seen; however, differences were not significant. Users of the system reported that its use had improved the overall quality of care delivered, was well-accepted by families, and improved guidance quality; however, 5 of 7 users reported that eye-to-eye contact with patients was reduced, and 4 of 7 reported that use of the system increased the duration of visits (mean: 9.3 minutes longer). All users recommended continued use of the system. Use of the EMR in this study was associated with improved quality of care. This experience suggests that EMRs can be successfully used in busy urban pediatric primary care centers and, as recommended by the Institute of Medicine, must play a central role in the redesign of the US health care system.

Work, social support and leisure protect the elderly from functional loss: EPIDOSO study.

PubMed

d'Orsi, Eleonora; Xavier, André Junqueira; Ramos, Luiz Roberto

2011-08-01

To identify risk factors for functional capacity loss in elderly people. Epidoso (Epidemiology of the Elderly) cohort study with elderly people living in São Paulo (Southeastern Brazil). A total of 326 participants in the first interview (1991-1992) who were independent or had mild dependence (one or two activities of daily living) were selected. Those who presented functional loss in the second (1994-1995) or third interviews (1998-1999) were compared to those who did not present it. The incidence of functional loss was calculated according to sociodemographic variables, life habits, cognitive status, morbidity, hospitalization, self-rated health, tooth loss, social support and leisure activities. Crude and adjusted relative risks with 95% confidence intervals were estimated through bivariate and multiple analyses with Poisson regression. The criterion for the inclusion of the variables in the model was p < 0.20 and for exclusion, p > 0.10. The incidence of functional loss was 17.8% (13.6; 21.9). The risk factors in the final model were: age group 70-74 years RR=1.9 (0.9;3.9); age group 75-79 years RR=2.8 (1.4;5.5); age group 80 years or older RR=5.4 (3.0;9.6); score in the mini-mental state examination <24 RR=1.8 (1.1;2.9); asthma RR=2.3 (1.3;3.9); hypertension RR=1.7 (1.1;2.6); and diabetes RR=1.7 (0.9;3.0). The protective factors were: paid work RR=0.3 (0.1;1.0); monthly relationship with friends RR=0.5 (0.3;0.8); watching TV RR=0.5 (0.3;0.9); and handcrafting RR=0.7 (0.4;1.0). The prevention of functional loss should include adequate control of chronic diseases, like hypertension, asthma and diabetes, as well as cognitive stimulation. Work, leisure and relationships with friends should be valued due to their protective effect.

Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmad, Md. Faiz; Kaushal, Prem Singh; Wan, Qun

2012-11-01

Ribonucleotide reductases (RRs) catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. Eukaryotic RRs consist of two proteins, RR1 ({alpha}) that contains the catalytic site and RR2 ({beta}) that houses a diferric-tyrosyl radical essential for ribonucleoside diphosphate reduction. Biochemical analysis has been combined with isothermal titration calorimetry (ITC), X-ray crystallography and yeast genetics to elucidate the roles of two loop 2 mutations R293A and Q288A in Saccharomyces cerevisiae RR1 (ScRR1). These mutations, R293A and Q288A, cause lethality and severe S phase defects, respectively, in cells that use ScRR1 as the sole source of RR1 activity. Compared to the wild-typemore » enzyme activity, R293A and Q288A mutants show 4% and 15%, respectively, for ADP reduction, whereas they are 20% and 23%, respectively, for CDP reduction. ITC data showed that R293A ScRR1 is unable to bind ADP and binds CDP with 2-fold lower affinity compared to wild-type ScRR1. With the Q288A ScRR1 mutant, there is a 6-fold loss of affinity for ADP binding and a 2-fold loss of affinity for CDP compared to the wild type. X-ray structures of R293A ScRR1 complexed with dGTP and AMPPNP-CDP [AMPPNP, adenosine 5-({beta},{gamma}-imido)triphosphate tetralithium salt] reveal that ADP is not bound at the catalytic site, and CDP binds farther from the catalytic site compared to wild type. Our in vivo functional analyses demonstrated that R293A cannot support mitotic growth, whereas Q288A can, albeit with a severe S phase defect. Taken together, our structure, activity, ITC and in vivo data reveal that the arginine 293 and glutamine 288 residues of ScRR1 are crucial in facilitating ADP and CDP substrate selection.« less

The Use of Radiation Response (RR) in Selecting the Method of Treatment of Carcinoma Cervicis Uteri

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chesterman, John N.

1963-03-01

Attempts were made to determine the choice treatment of cervical squamous carcinoma (surgery, radiation, or surgery with radiation) in Stages I and II. A study of 50 patients showed good results from surgery in patients with poor radiation response (RR) and that the RR, estimated by a precise and uniform technique, will identify those patients who will not respond well to complete radiation therapy. Moreover, it will do this after a first radium application of moderate dosage, at a time when it is still possible to interrupt this therapy. A radiation dose of at least 1000 r at the cervixmore » will be followed by the maximum RR, in a good response, between the 8th and 14th (especially 10th to 12th) days. A poor RR will reach its maximum earlier than a good one, on about the 10th day after radium implantation. When deciding the definition of good RR, it was found that the radiation changes present in a count of 100 cells were seen in more than 70 cells. There is evidence that age, menopause, and hormonal status influence the radiation reaction. If poor RR is more frequently found with high estrogenic activity, young patients treated by radiation should be expected to have a worse survival rate than old. The survival rate is about 1/3) in the young patient as against 1/2 in the postmenopausal. A good sensitization response (SR) was, in most cases, followed by good RR after radiation. Of 39 patients with good SR, 34 had good RR after one application of radium. However, this correlation was absent when the SR was poor. Of 41 patients with poor SR, 18 remained poor after radiation and 23 developed good RR. Finally, this SR should not be taken alone as a guide to treatment, but all patients should be given the first radium application and the RR assessed.« less

PRISMA--efficacy and safety of vedolizumab for inflammatory bowel diseases: a systematic review and meta-analysis of randomized controlled trials.

PubMed

Wang, Man Cai; Zhang, Ling Yi; Han, Wei; Shao, Yuan; Chen, Mo; Ni, Rui; Wang, Gen Nian; Wei, Feng Xian; Zhang, Ya Wu; Xu, Xiao Dong; Zhang, You Cheng

2014-12-01

Vedolizumab is an anti-inflammatory monoclonal antibody that exclusively targets the α4β7 integrin. We aimed to systematically review the efficacy and safety of vedolizumab for patients with inflammatory bowel diseases (IBDs). PubMed, EMBASE, and the Cochrane Library were searched up to May 2014. Randomized controlled trials examining the efficacy or safety of vedolizumab in patients with IBDs were eligible for inclusion. Data were extracted independently by 2 investigators and pooled using Review Manager 5.0 software (The Cochrane Collaboration, Copenhagen). Results were expressed as the relative risk (RR) with 95% confidence intervals (CIs). Six randomized controlled trials involving 2815 patients were eligible for inclusion. Vedolizumab was more effective than placebo for patients with ulcerative colitis and Crohn disease (CD) in clinical response (RR=1.82, 95% CI, [1.43, 2.31]; RR=1.46, 95% CI [1.18,1.81]) and clinical remission (RR=2.23, 95% CI [1.35, 3.68]; RR=1.71, 95% CI [1.25, 2.34]) during induction therapy. A superior effect was found during maintenance therapy in durable clinical/CD Activity Index-100 response (RR=2.22, 95% CI [1.62, 3.05]; RR=1.48, 95% CI [1.13, 1.94]) and clinical remission (RR=2.55, 95% CI [1.38, 4.70]; RR=1.15, 95% CI [0.75, 1.77]). However, vedolizumab may be associated with serious adverse events (RR=1.25, 95% CI [1.03, 1.52]) and nasopharyngitis (RR=1.56, 95% CI [1.08, 2.25]) for patients with CD. Vedolizumab was more effective than placebo as induction and maintenance therapy for IBDs, with an acceptable short-term safety profile, and achieving cure, although it may be associated with serious adverse events and nasopharyngitis for patients with CD.

Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.

PubMed

Qiu, Weihua; Zhou, Bingsen; Darwish, Dana; Shao, Jimin; Yen, Yun

2006-02-10

Ribonucleotide reductase (RR) is a highly regulated enzyme in the deoxyribonucleotide synthesis pathway. RR is responsible for the de novo conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. Besides two subunits, hRRM1 and hRRM2, p53R2 is a newly identified member of RR family that is induced by ultraviolet light in a p53-dependent manner. To understand the molecular interaction of RR subunits, we employed a eukaryotic expression system to express and purify all three subunits. After in vitro reconstitution, the results of [(3)H]CDP reduction assay showed that both eukaryotic recombinant hRRM2 and p53R2 proteins could interact with hRRM1 to form functional RR holoenzyme. The reconstituted RR activity was time-dependent and the reaction rate reached the plateau phase after 40min incubation. No matter the concentration, RR holoenzyme reconstituted from p53R2 and hRRM1 could only achieve about 40-75% kinetic activity of that from hRRM2 and hRRM1. The synthetic C-terminal heptapeptide competition assays confirmed that hRRM2 and p53R2 share the same binding site on hRRM1, but the binding site on hRRM1 demonstrated higher affinity for hRRM2 than for p53R2. In allosteric regulation assay, the effect of activation or inhibition of hRRM1 with ATP or dATP suggested that these effectors could regulate RR activity independent of different RR small subunits. Taken together, the eukaryotic expression system RR holoenzyme will provide a very useful tool to understand the molecular mechanisms of RR activity and the interactions of its subunits.

Social networks and mortality based on the Komo-Ise cohort study in Japan.

PubMed

Iwasaki, Motoki; Otani, Tetsuya; Sunaga, Rumiko; Miyazaki, Hiroko; Xiao, Liu; Wang, Naren; Yosiaki, Sasazawa; Suzuki, Shosuke

2002-12-01

No prospective studies have examined the association between social networks and all-cause and cause-specific mortality among middle-aged Japanese. The study of varied populations may contribute to clarifying the robustness of the observed effects of social networks and extend their generalizability. To clarify the association between social networks and mortality among middle-aged and elderly Japanese, a community-based prospective study, the Komo-Ise Study, was conducted in two areas of Gunma Prefecture, Japan. A total of 11 565 subjects aged 40-69 years at baseline in 1993 completed a self-administered questionnaire. During the 7-year follow-up period, 335 men and 155 women died and the relative risk (RR) of each social network item was estimated by the Cox proportional hazard model. Single women had significantly increased risks of all-cause (multivariate RR = 2.2), and all circulatory system disease (age-area adjusted RR = 2.6) mortality. Men who did not participate in hobbies, club activities, or community groups had significantly higher multivariate RR for all-cause (RR = 1.5), all circulatory system disease (RR = 1.6) and non-cancer and non-circulatory system disease (RR = 2.3) mortality. Urban women who rarely or never met close relatives had significantly elevated risks of all-cause (RR = 2.4), all cancer (RR = 2.6), and non-cancer and non-circulatory system disease (RR = 2.7) mortality after adjustment for established risk factors. This study provides evidence that social networks are an important predictor of mortality risk for middle-aged and elderly Japanese men and women. Lack of participation, for men, and being single and lack of meeting close relatives, for women, were independent risk factors for mortality.

Relative risk of listeriosis in Foodborne Diseases Active Surveillance Network (FoodNet) sites according to age, pregnancy, and ethnicity.

PubMed

Pouillot, Régis; Hoelzer, Karin; Jackson, Kelly A; Henao, Olga L; Silk, Benjamin J

2012-06-01

Quantitative estimates of the relative risk (RR) of listeriosis among higher-risk populations and a nuanced understanding of the age-specific risks are crucial for risk assessments, targeted interventions, and policy decisions. The RR of invasive listeriosis was evaluated by age, pregnancy status, and ethnicity using 2004-2009 data from the Foodborne Diseases Active Surveillance Network (FoodNet). Nonparametric logistic regression was used to characterize changes in risk with age and ethnicity. Adjusted RRs and 95% confidence intervals (CIs) were evaluated using negative binomial generalized linear models. Among non-pregnancy-associated cases, listeriosis incidence rates increased gradually with age (45-59 years: RR, 4.7; 95% CI, 3.3-6.8; >85 years: RR, 53.8; 95% CI, 37.3-78.9; reference: 15-44 years). The RR was significantly higher for Hispanics than for non-Hispanics (RR, 1.8; 95% CI, 1.3-2.5). Among women of reproductive age (15-44 years), pregnant women had a markedly higher listeriosis risk (RR, 114.6; 95% CI, 68.9-205.1) than nonpregnant women. The RR was higher for Hispanic than non-Hispanic women, regardless of pregnancy status, and this increased during the study period (2004-2006: RR, 1.9; 95% CI, 1.0-3.3; 2007-2009: RR, 4.8; 95% CI, 3.1-7.1). This study quantifies the increases in risk of listeriosis among older persons, pregnant women, and Hispanics in the United States. Additional research is needed to better describe the independent effects of age on risk while accounting for underlying conditions. These estimates are needed both to optimize risk assessment models and to inform targeted interventions and policy decisions.

Failure to Redose Antibiotic Prophylaxis in Long Surgery Increases Risk of Surgical Site Infection.

PubMed

Kasatpibal, Nongyao; Whitney, Joanne D; Dellinger, E Patchen; Nair, Bala G; Pike, Kenneth C

Antibiotic prophylaxis is a key component of the prevention of surgical site infection (SSI). Failure to manage antibiotic prophylaxis effectively may increase the risk of SSI. This study aimed to examine the effects of antibiotic prophylaxis on SSI risk. A retrospective cohort study was conducted among patients having general surgery between May 2012 and June 2015 at the University of Washington Medical Center. Peri-operative data extracted from hospital databases included patient and operation characteristics, intra-operative medication and fluid administration, and survival outcome. The effects of antibiotic prophylaxis and potential factors on SSI risk were estimated using multiple logistic regression and were expressed as risk ratios (RRs). A total of 4,078 patients were eligible for analysis. Of these, 180 had an SSI. Mortality rates within and after 30 days were 0.8% and 0.3%, respectively. Improper antibiotic redosing increased the risk of SSI (RR 4.61; 95% confidence interval [CI] 1.33-15.91). Other risk factors were in-patient status (RR 4.05; 95% CI 1.69-9.66), smoking (RR 1.63; 95% CI 1.03-2.55), emergency surgery (RR 1.97; 95% CI 1.26-3.08), colectomy (RR 3.31; 95% CI 1.19-9.23), pancreatectomy (RR 4.52; 95% CI 1.53-13.39), proctectomy (RR 5.02; 95% CI 1.72-14.67), small bowel surgery (RR 6.16; 95% CI 2.13-17.79), intra-operative blood transfusion >500 mL (RR 2.76; 95% CI 1.45-5.26), and multiple procedures (RR 1.40; 95% CI 1.01-1.95). These data demonstrate that failure to redose prophylactic antibiotic during long operations increases the risk of SSI. Strengthening a collaborative surgical quality improvement program may help to eradicate this risk.

R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease.

PubMed

Reimann, M J; Møller, J E; Häggström, J; Markussen, B; Holen, A E W; Falk, T; Olsen, L H

2014-03-01

Mitral regurgitation (MR) due to myxomatous mitral valve disease (MMVD) is a frequent finding in Cavalier King Charles Spaniels (CKCSs). Sinus arrhythmia and atrial premature complexes leading to R-R interval variations occur in dogs. The aim of the study was to evaluate whether the duration of the R-R interval immediately influences the degree of MR assessed by echocardiography in dogs. Clinical examination including echocardiography was performed in 103 privately-owned dogs: 16 control Beagles, 70 CKCSs with different degree of MR and 17 dogs of different breeds with clinical signs of congestive heart failure due to MMVD. The severity of MR was evaluated in apical four-chamber view using colour Doppler flow mapping (maximum % of the left atrium area) and colour Doppler M-mode (duration in ms). The influence of the ratio between present and preceding R-R interval on MR severity was evaluated in 10 consecutive R-R intervals using a linear mixed model for repeated measurements. MR severity was increased when a short R-R interval was followed by a long R-R interval in CKCSs with different degrees of MR (P<0.005 when adjusted for multiple testing). The relationship was not significant in control dogs with minimal MR and in dogs with severe MR and clinical signs of heart failure. In conclusion, MR severity increases in long R-R intervals when these follow a short R-R interval in CKCSs with different degrees of MR due to asymptomatic MMVD. Thus, R-R interval variations may affect the echocardiographic grading of MR in CKCSs. Copyright © 2014 Elsevier Ltd. All rights reserved.

RcRR1, a Rosa canina type-A response regulator gene, is involved in cytokinin-modulated rhizoid organogenesis.

PubMed

Gao, Bin; Fan, Lusheng; Li, Xingxing; Yang, Huifang; Liu, Fengluan; Wang, Ling; Xi, Lin; Ma, Nan; Zhao, Liangjun

2013-01-01

In vitro, a new protocol of plant regeneration in rose was achieved via protocorm-like bodies (PLBs) induced from the root-like organs named rhizoids that developed from leaf explants. The development of rhizoids is a critical stage for efficient regeneration, which is triggered by exogenous auxin. However, the role of cytokinin in the control of organogenesis in rose is as yet uncharacterized. The aim of this study was to elucidate the molecular mechanism of cytokinin-modulated rhizoid formation in Rosa canina. Here, we found that cytokinin is a key regulator in the formation of rhizoids. Treatment with cytokinin reduced callus activity and significantly inhibited rhizoid formation in Rosa canina. We further isolated the full-length cDNA of a type-A response regulator gene of cytokinin signaling, RcRR1, from which the deduced amino acid sequence contained the conserved DDK motif. Gene expression analysis revealed that RcRR1 was differentially expressed during rhizoid formation and its expression level was rapidly up-regulated by cytokinin. In addition, the functionality of RcRR1 was tested in Arabidopsis. RcRR1 was found to be localized to the nucleus in GFP-RcRR1 transgenic plants and overexpression of RcRR1 resulted in increased primary root length and lateral root density. More importantly, RcRR1 overexpression transgenic plants also showed reduced sensitivity to cytokinin during root growth; auxin distribution and the expression of auxin efflux carriers PIN genes were altered in RcRR1 overexpression plants. Taken together, these results demonstrate that RcRR1 is a functional type-A response regulator which is involved in cytokinin-regulated rhizoid formation in Rosa canina.

Susceptibility of field populations of the diamondback moth, Plutella xylostella, to a selection of insecticides in Central China.

PubMed

Zhang, Shuzhen; Zhang, Xiaolei; Shen, Jun; Mao, Kaikai; You, Hong; Li, Jianhong

2016-09-01

The diamondback moth (DBM), Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a globally distributed and important economic pest. Chemical control is the primary approach to regulate populations of this pest. However, resistance to insecticides evolves following heavy and frequent use. Therefore, the insecticide resistance in field populations of P. xylostella collected from Central China from 2013 to 2014 was determined with a leaf-dipping method. Based on the results of the monitoring, P. xylostella has developed high levels of resistance to beta-cypermethrin (resistance ratio=69.76-335.76-fold), Bt (WG-001) (RR=35.43-167.36), and chlorfluazuron (RR=13.60-104.95) and medium levels of resistance to chlorantraniliprole (RR=1.19-14.26), chlorfenapyr (RR=4.22-13.44), spinosad (RR=5.89-21.45), indoxacarb (RR=4.01-34.45), and abamectin (RR=23.88-95.15). By contrast, the field populations of P. xylostella remained susceptible to or developed low levels of resistance to diafenthiuron (RR=1.61-8.05), spinetoram (RR=0.88-2.35), and cyantraniliprole (RR=0.4-2.15). Moreover, the LC50 values of field populations of P. xylostella were highly positively correlated between chlorantraniliprole and cyantraniliprole (r=0.88, P=0.045), chlorantraniliprole and spinosad (r=0.66, P=0.039), spinosad and diafenthiuron (r=0.57, P=0.0060), and chlorfenapyr and diafenthiuron (r=0.51, P=0.016). Additionally, the activities of detoxification enzymes in field populations of P. xylostella were significantly positively correlated with the log LC50 values of chlorantraniliprole and spinosad. The results of this study provide an important base for developing effective and successful strategies to manage insecticide resistance in P. xylostella. Copyright © 2016 Elsevier B.V. All rights reserved.

RcRR1, a Rosa canina Type-A Response Regulator Gene, Is Involved in Cytokinin-Modulated Rhizoid Organogenesis

PubMed Central

Li, Xingxing; Yang, Huifang; Liu, Fengluan; Wang, Ling; Xi, Lin; Ma, Nan; Zhao, Liangjun

2013-01-01

In vitro, a new protocol of plant regeneration in rose was achieved via protocorm-like bodies (PLBs) induced from the root-like organs named rhizoids that developed from leaf explants. The development of rhizoids is a critical stage for efficient regeneration, which is triggered by exogenous auxin. However, the role of cytokinin in the control of organogenesis in rose is as yet uncharacterized. The aim of this study was to elucidate the molecular mechanism of cytokinin-modulated rhizoid formation in Rosa canina. Here, we found that cytokinin is a key regulator in the formation of rhizoids. Treatment with cytokinin reduced callus activity and significantly inhibited rhizoid formation in Rosa canina. We further isolated the full-length cDNA of a type-A response regulator gene of cytokinin signaling, RcRR1, from which the deduced amino acid sequence contained the conserved DDK motif. Gene expression analysis revealed that RcRR1 was differentially expressed during rhizoid formation and its expression level was rapidly up-regulated by cytokinin. In addition, the functionality of RcRR1 was tested in Arabidopsis. RcRR1 was found to be localized to the nucleus in GFP-RcRR1 transgenic plants and overexpression of RcRR1 resulted in increased primary root length and lateral root density. More importantly, RcRR1 overexpression transgenic plants also showed reduced sensitivity to cytokinin during root growth; auxin distribution and the expression of auxin efflux carriers PIN genes were altered in RcRR1 overexpression plants. Taken together, these results demonstrate that RcRR1 is a functional type-A response regulator which is involved in cytokinin-regulated rhizoid formation in Rosa canina. PMID:24009713

Dynamics of forest populations in the mountain resort region of the North Caucasus

NASA Astrophysics Data System (ADS)

Chalaya, Elena; Efimenko, Natalia; Slepykh, Olga; Slepykh, Viktor; Povolotskaya, Nina

2017-04-01

Prehistoric formula of forest species composition of the resort region Caucasian Mineralnye Vody (RR CMV) in the North Caucasus is 6Q3Cb1Fe [1]. According to it, undisturbed forests of the region consisted of the pedunculate oak (Quercus robur L.) and the durmast (Quercus cerris L.) by 60%, the European hornbeam (Carpinus betulus L.) by 30% and the European ash (Fraxinus excelsior L.) only by 10%. At present the formula of forest composition of the region is 5Fe3Cb2Q, according to it, the rate of oak-groves (the most valuable to resort landscape gardening) has reduced to 20%, and the ash-tree, though the rate of the hornbeam has not changed, increased up to 50%. Forest breeding populations in the RR CMV are referred to natural medical resources as they have high rehabilitation and climate-regulating properties, the change in forest breeding populations influences the conditions of the resort climate-landscape-therapy. The researches conducted in the perfect oak wood of vegetative origin in Beshtaugorsky Forestry Area (BFA) of the RR CMV have shown the reduction of the pedunculate oak in the tree-stand composition during 1984-2014 from 10 to 8 units in the composition: the European ash (1 unit) and the crataegus monogyna (Crataegus monogyna Jacq.), the checker tree (Sorbus torminalis (L.) Crantz), the common pear (Pyrus communis L.) have appeared [2]. The rate of the pedunculate oak decreased from 10 units to 9 in the perfect planting of the pedunculate oak of the artificial origin (Mashuk section of the forestry of BFA of the RR CMV) during 1986-2016. Among accompanying breeds there was the English field maple (Acer campestre L.), the Chinese elm in singular (Ulmus parvifolia Jacq.), the single-seed hawthorn. The reliable regrowth (4C3Fe3Ac+Q+Cm+Pc+Up) in number of 3,9 thousand pieces/hectare defines the perspective of complete replacement of the oak crop in the future on planting with dominance of the hornbeam and the involvement of the ash-tree and the English field maple. Succession of the oak replacement in natural stand of the vegetative origin can be explained with the soil fatigue under the oak forest inhibiting its own regrowth [2]. However, you can observe the same succession of the oak replacement by other native species in the artificial planting of the oak on the virgin meadow lands. Therefore, the exogenous factors proceeding against the background of global warming during the number of decades are the reason of the succession. The nature of this process demands further studying. References 1.Kazankin A.P. Ecological role of the mountain woods of the Caucasus. Novosibirsk: Siberian Branch of the Russian Academy of Science publishing house, 2013. - 366 p. 2. Slepykh, V.V. Successions and bioclimate of oak groves in the resort region Caucasian MineralnyeVody / V.V.Slepykh, N.P.Povolotskaya// Resort medicine, № 3, 2015. - P. 18-27.

RR Lyrae in the UMi dSph Galaxy

NASA Astrophysics Data System (ADS)

Kuehn, Charles; Kinemuchi, Karen; Jeffery, Elizabeth; Grabowski, Kathleen; Nemec, James; Herrera, Daniel

2018-01-01

Over the past two years we have obtained observations of the Ursa Minor dwarf spheroidal galaxy with the goal of completing an updated catalog of the variable stars in the dwarf galaxy. In addition to finding new variable stars, this updated catalog will allow us to look at period changes in the variables and to determine stellar characteristic for the RR Lyrae stars in the dSph. We will compare the RR Lyrae stellar characteristics to other RR Lyrae stars found in the Local Group dSph galaxies; these comparisons can give us insights to the near-field cosmology of the Local Group. In this poster we present our updated catalog of RR Lyrae stars in the UMi dSph; the updated catalog includes Fourier decomposition parameters, metallicities, and other physical properties for the RR Lyrae stars.

Effects of controlled breathing, mental activity and mental stress with or without verbalization on heart rate variability.

PubMed

Bernardi, L; Wdowczyk-Szulc, J; Valenti, C; Castoldi, S; Passino, C; Spadacini, G; Sleight, P

2000-05-01

To assess whether talking or reading (silently or aloud) could affect heart rate variability (HRV) and to what extent these changes require a simultaneous recording of respiratory activity to be correctly interpreted. Sympathetic predominance in the power spectrum obtained from short- and long-term HRV recordings predicts a poor prognosis in a number of cardiac diseases. Heart rate variability is often recorded without measuring respiration; slow breaths might artefactually increase low frequency power in RR interval (RR) and falsely mimic sympathetic activation. In 12 healthy volunteers we evaluated the effect of free talking and reading, silently and aloud, on respiration, RR and blood pressure (BP). We also compared spontaneous breathing to controlled breathing and mental arithmetic, silent or aloud. The power in the so called low- (LF) and high-frequency (HF) bands in RR and BP was obtained from autoregressive power spectrum analysis. Compared with spontaneous breathing, reading silently increased the speed of breathing (p < 0.05), decreased mean RR and RR variability and increased BP. Reading aloud, free talking and mental arithmetic aloud shifted the respiratory frequency into the LF band, thus increasing LF% and decreasing HF% to a similar degree in both RR and respiration, with decrease in mean RR but with minor differences in crude RR variability. Simple mental and verbal activities markedly affect HRV through changes in respiratory frequency. This possibility should be taken into account when analyzing HRV without simultaneous acquisition and analysis of respiration.

[Tobacco smoke and risk of bacterial infection].

PubMed

Trosini-Desert, V; Germaud, P; Dautzenberg, B

2004-06-01

Tobacco smoke is a proven risk factor for bacterial infection. In adults without COPD, smoking is associated with a significant increase in the relative risk (RR) of pneumonia (RR=2.97; 95% CI 1.52-5.81), S pneumoniae pneumonia (RR=2.50; 95% IC 1.50-5.10), Legionella infection (RR=3.75; 95% CI 2.17-6.17). Smoking has clearly been shown to be associated with an increased risk of tuberculosis (RR=2.60; 95% CI 2,20-3,20), and also with increased incidence of post-operative infections. In young children whose parents smoke, passive exposure to tobacco smoke is associated with an increased relative risk of seasonal infections (RR=1.7; CI 95% 1.55-1.91) and recurrent otitis media (RR=1.48; 95% CI 1.08-2.04). Passive smoking also increases risk of pneumonia in adults (RR=2.5; CI 95% 1.2-5.1). Plausible explanations of the increased risk of infection in active or passive smokers include increased bacterial adherence, decrease of lung and nasal clearance, and changes in the immune response. Exposure to tobacco smoke approximately doubles the risk of infection. This increased burden of infection has significant healthcare cost implications. Each infectious episode in an individual should prompt an attempt at smoking cessation.

Important influence of respiration on human R-R interval power spectra is largely ignored

NASA Technical Reports Server (NTRS)

Brown, T. E.; Beightol, L. A.; Koh, J.; Eckberg, D. L.

1993-01-01

Frequency-domain analyses of R-R intervals are used widely to estimate levels of autonomic neural traffic to the human heart. Because respiration modulates autonomic activity, we determined for nine healthy subjects the influence of breathing frequency and tidal volume on R-R interval power spectra (fast-Fourier transform method). We also surveyed published literature to determine current practices in this burgeoning field of scientific inquiry. Supine subjects breathed at rates of 6, 7.5, 10, 15, 17.1, 20, and 24 breaths/min and with nominal tidal volumes of 1,000 and 1,500 ml. R-R interval power at respiratory and low (0.06-0.14 Hz) frequencies declined significantly as breathing frequency increased. R-R interval power at respiratory frequencies was significantly greater at a tidal volume of 1,500 than 1,000 ml. Neither breathing frequency nor tidal volume influenced average R-R intervals significantly. Our review of studies reporting human R-R interval power spectra showed that 51% of the studies controlled respiratory rate, 11% controlled tidal volume, and 11% controlled both respiratory rate and tidal volume. The major implications of our analyses are that breathing parameters strongly influence low-frequency as well as respiratory frequency R-R interval power spectra and that this influence is largely ignored in published research.

Quantifying radar-rainfall uncertainties in urban drainage flow modelling

NASA Astrophysics Data System (ADS)

Rico-Ramirez, M. A.; Liguori, S.; Schellart, A. N. A.

2015-09-01

This work presents the results of the implementation of a probabilistic system to model the uncertainty associated to radar rainfall (RR) estimates and the way this uncertainty propagates through the sewer system of an urban area located in the North of England. The spatial and temporal correlations of the RR errors as well as the error covariance matrix were computed to build a RR error model able to generate RR ensembles that reproduce the uncertainty associated with the measured rainfall. The results showed that the RR ensembles provide important information about the uncertainty in the rainfall measurement that can be propagated in the urban sewer system. The results showed that the measured flow peaks and flow volumes are often bounded within the uncertainty area produced by the RR ensembles. In 55% of the simulated events, the uncertainties in RR measurements can explain the uncertainties observed in the simulated flow volumes. However, there are also some events where the RR uncertainty cannot explain the whole uncertainty observed in the simulated flow volumes indicating that there are additional sources of uncertainty that must be considered such as the uncertainty in the urban drainage model structure, the uncertainty in the urban drainage model calibrated parameters, and the uncertainty in the measured sewer flows.

RR-Interval variance of electrocardiogram for atrial fibrillation detection

NASA Astrophysics Data System (ADS)

Nuryani, N.; Solikhah, M.; Nugoho, A. S.; Afdala, A.; Anzihory, E.

2016-11-01

Atrial fibrillation is a serious heart problem originated from the upper chamber of the heart. The common indication of atrial fibrillation is irregularity of R peak-to-R-peak time interval, which is shortly called RR interval. The irregularity could be represented using variance or spread of RR interval. This article presents a system to detect atrial fibrillation using variances. Using clinical data of patients with atrial fibrillation attack, it is shown that the variance of electrocardiographic RR interval are higher during atrial fibrillation, compared to the normal one. Utilizing a simple detection technique and variances of RR intervals, we find a good performance of atrial fibrillation detection.

Conversational Memory Employing Cued and Free Recall.

ERIC Educational Resources Information Center

Benoit, Pamela J.; Benoit, William L.

1988-01-01

Tests two hypotheses: (1) that cued recall elicits significantly more conversational information than free recall; and (2) that conversational interactants recall more of their partner's utterances than their own. Finds cued recall produced significantly higher amounts of remembering than free recall. (MS)

Prosodic Contrasts in Ironic Speech

ERIC Educational Resources Information Center

Bryant, Gregory A.

2010-01-01

Prosodic features in spontaneous speech help disambiguate implied meaning not explicit in linguistic surface structure, but little research has examined how these signals manifest themselves in real conversations. Spontaneously produced verbal irony utterances generated between familiar speakers in conversational dyads were acoustically analyzed…

Research on the Solid State Fermentation of Jerusalem Artichoke Pomace for Producing R,R-2,3-Butanediol by Paenibacillus polymyxa ZJ-9.

PubMed

Cao, Can; Zhang, Li; Gao, Jian; Xu, Hong; Xue, Feng; Huang, Weiwei; Li, Yan

2017-06-01

R,R-2,3-butanediol (R,R-2,3-BD) was produced by Paenibacillus polymyxa ZJ-9, which was capable of utilizing inulin without previous hydrolysis. The Jerusalem artichoke pomace (JAP) derived from the conversion of Jerusalem artichoke powder into inulin extract, which was usually used for biorefinery by submerged fermentation (SMF), was utilized in solid state fermentation (SSF) to produce R,R-2,3-BD. In this study, the fermentation parameters of SSF were optimized and determined in flasks. A novel bioreactor was designed and assembled for the laboratory scale-up of SSF, with a maximum yield of R,R-2,3-BD (67.90 g/kg (JAP)). This result is a 36.3% improvement compared with the flasks. Based on the same bath of Jerusalem artichoke powder, the total output of R,R-2,3-BD increased by 38.8% for the SSF of JAP combined with the SMF of inulin extraction. Overall, the utilization of JAP for R,R-2,3-BD production was beneficial to the comprehensive utilization of Jerusalem artichoke tuber.

Different types of dietary advice for women with gestational diabetes mellitus.

PubMed

Han, Shanshan; Middleton, Philippa; Shepherd, Emily; Van Ryswyk, Emer; Crowther, Caroline A

2017-02-25

Dietary advice is the main strategy for managing gestational diabetes mellitus (GDM). It remains unclear what type of advice is best. To assess the effects of different types of dietary advice for women with GDM for improving health outcomes for women and babies. We searched Cochrane Pregnancy and Childbirth's Trials Register (8 March 2016), PSANZ's Trials Registry (22 March 2016) and reference lists of retrieved studies. Randomised controlled trials comparing the effects of different types of dietary advice for women with GDM. Two authors independently assessed study eligibility, risk of bias, and extracted data. Evidence quality for two comparisons was assessed using GRADE, for primary outcomes for the mother: hypertensive disorders of pregnancy; caesarean section; type 2 diabetes mellitus; and child: large-for-gestational age; perinatal mortality; neonatal mortality or morbidity composite; neurosensory disability; secondary outcomes for the mother: induction of labour; perineal trauma; postnatal depression; postnatal weight retention or return to pre-pregnancy weight; and child: hypoglycaemia; childhood/adulthood adiposity; childhood/adulthood type 2 diabetes mellitus. In this update, we included 19 trials randomising 1398 women with GDM, at an overall unclear to moderate risk of bias (10 comparisons). For outcomes assessed using GRADE, downgrading was based on study limitations, imprecision and inconsistency. Where no findings are reported below for primary outcomes or pre-specified GRADE outcomes, no data were provided by included trials. Primary outcomes Low-moderate glycaemic index (GI) versus moderate-high GI diet (four trials): no clear differences observed for: large-for-gestational age (risk ratio (RR) 0.71, 95% confidence interval (CI) 0.22 to 2.34; two trials, 89 infants; low-quality evidence); severe hypertension or pre-eclampsia (RR 1.02, 95% CI 0.07 to 15.86; one trial, 95 women; very low-quality evidence); eclampsia (RR 0.34, 95% CI 0.01 to 8.14; one trial, 83 women; very low-quality evidence) or caesarean section (RR 0.66, 95% CI 0.29 to 1.47; one trial, 63 women; low-quality evidence). Energy-restricted versus no energy-restricted diet (three trials): no clear differences seen for: large-for-gestational age (RR 1.17, 95% CI 0.65 to 2.12; one trial, 123 infants; low-quality evidence); perinatal mortality (no events; two trials, 423 infants; low-quality evidence); pre-eclampsia (RR 1.00, 95% CI 0.51 to 1.97; one trial, 117 women; low-quality evidence); or caesarean section (RR 1.12, 95% CI 0.80 to 1.56; two trials, 420 women; low-quality evidence). DASH (Dietary Approaches to Stop Hypertension) diet versus control diet (three trials): no clear differences observed for: pre-eclampsia (RR 1.00, 95% CI 0.31 to 3.26; three trials, 136 women); however there were fewer caesarean sections in the DASH diet group (RR 0.53, 95% CI 0.37 to 0.76; two trials, 86 women). Low-carbohydrate versus high-carbohydrate diet (two trials): no clear differences seen for: large-for-gestational age (RR 0.51, 95% CI 0.13 to 1.95; one trial, 149 infants); perinatal mortality (RR 3.00, 95% CI 0.12 to 72.49; one trial, 150 infants); maternal hypertension (RR 0.40, 95% CI 0.13 to 1.22; one trial, 150 women); or caesarean section (RR 1.29, 95% CI 0.84 to 1.99; two trials, 179 women). High unsaturated fat versus low unsaturated fat diet (two trials): no clear differences observed for: large-for-gestational age (RR 0.54, 95% CI 0.21 to 1.37; one trial, 27 infants); pre-eclampsia (no cases; one trial, 27 women); hypertension in pregnancy (RR 0.54, 95% CI 0.06 to 5.26; one trial, 27 women); caesarean section (RR 1.08, 95% CI 0.07 to 15.50; one trial, 27 women); diabetes at one to two weeks (RR 2.00, 95% CI 0.45 to 8.94; one trial, 24 women) or four to 13 months postpartum (RR 1.00, 95% CI 0.10 to 9.61; one trial, six women). Low-GI versus high-fibre moderate-GI diet (one trial): no clear differences seen for: large-for-gestational age (RR 2.87, 95% CI 0.61 to 13.50; 92 infants); caesarean section (RR 1.91, 95% CI 0.91 to 4.03; 92 women); or type 2 diabetes at three months postpartum (RR 0.76, 95% CI 0.11 to 5.01; 58 women). Diet recommendation plus diet-related behavioural advice versus diet recommendation only (one trial): no clear differences observed for: large-for-gestational age (RR 0.73, 95% CI 0.25 to 2.14; 99 infants); or caesarean section (RR 0.78, 95% CI 0.38 to 1.62; 99 women). Soy protein-enriched versus no soy protein diet (one trial): no clear differences seen for: pre-eclampsia (RR 2.00, 95% CI 0.19 to 21.03; 68 women); or caesarean section (RR 1.00, 95% CI 0.57 to 1.77; 68 women). High-fibre versus standard-fibre diet (one trial): no primary outcomes reported. Ethnic-specific versus standard healthy diet (one trial): no clear differences observed for: large-for-gestational age (RR 0.14, 95% CI 0.01 to 2.45; 20 infants); neonatal composite adverse outcome (no events; 20 infants); gestational hypertension (RR 0.33, 95% CI 0.02 to 7.32; 20 women); or caesarean birth (RR 1.20, 95% CI 0.54 to 2.67; 20 women). Secondary outcomes For secondary outcomes assessed using GRADE no differences were observed: between a low-moderate and moderate-high GI diet for induction of labour (RR 0.88, 95% CI 0.33 to 2.34; one trial, 63 women; low-quality evidence); or an energy-restricted and no energy-restricted diet for induction of labour (RR 1.02, 95% CI 0.68 to 1.53; one trial, 114 women, low-quality evidence) and neonatal hypoglycaemia (average RR 1.06, 95% CI 0.48 to 2.32; two trials, 408 infants; very low-quality evidence).Few other clear differences were observed for reported outcomes. Longer-term health outcomes and health services use and costs were largely not reported. Evidence from 19 trials assessing different types of dietary advice for women with GDM suggests no clear differences for primary outcomes and secondary outcomes assessed using GRADE, except for a possible reduction in caesarean section for women receiving a DASH diet compared with a control diet. Few differences were observed for secondary outcomes.Current evidence is limited by the small number of trials in each comparison, small sample sizes, and variable methodological quality. More evidence is needed to assess the effects of different types of dietary advice for women with GDM. Future trials should be adequately powered to evaluate short- and long-term outcomes.

Compression based entropy estimation of heart rate variability on multiple time scales.

PubMed

Baumert, Mathias; Voss, Andreas; Javorka, Michal

2013-01-01

Heart rate fluctuates beat by beat in a complex manner. The aim of this study was to develop a framework for entropy assessment of heart rate fluctuations on multiple time scales. We employed the Lempel-Ziv algorithm for lossless data compression to investigate the compressibility of RR interval time series on different time scales, using a coarse-graining procedure. We estimated the entropy of RR interval time series of 20 young and 20 old subjects and also investigated the compressibility of randomly shuffled surrogate RR time series. The original RR time series displayed significantly smaller compression entropy values than randomized RR interval data. The RR interval time series of older subjects showed significantly different entropy characteristics over multiple time scales than those of younger subjects. In conclusion, data compression may be useful approach for multiscale entropy assessment of heart rate variability.