DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, W. H.; HEDPS and CAPT, Peking University, Beijing 100871; Wang, L. F.

In this research, the temporal evolution of the bubble tip velocity in Rayleigh-Taylor instability (RTI) at arbitrary Atwood numbers and different initial perturbation velocities with a discontinuous profile in irrotational, incompressible, and inviscid fluids (i.e., classical RTI) is investigated. Potential models from Layzer [Astrophys. J. 122, 1 (1955)] and perturbation velocity potentials from Goncharov [Phys. Rev. Lett. 88, 134502 (2002)] are introduced. It is found that the temporal evolution of bubble tip velocity [u(t)] depends essentially on the initial perturbation velocity [u(0)]. First, when the u(0)

Policy Implications at the State and District Level with RtI for Gifted students

ERIC Educational Resources Information Center

Brown, Elissa F.; Abernethy, Sherry H.

2009-01-01

As a field, gifted education does not endorse any one approach to serving students because of the range of student abilities and resulting concomitant diverse needs. Therefore, service delivery in gifted education is still heavily teacher dependent. Yet, many of the components of Response to Intervention (RtI) are employed in gifted education,…

A Qualitative Study of Systemic Factors Contributing to Successful Implementation of Response to Intervention Programs in Elementary Schools

ERIC Educational Resources Information Center

White, Sheila B.

2017-01-01

Response to intervention (RTI), an educational reform effort designed to meet the needs of struggling learners, has been adopted by an increasing number of states as a primary component of their educational service delivery model for low-achieving students (Burns et al., 2013; Castillo & Batsche, 2012). RTI models are multi-tiered…

Technology Applications Team: Applications of aerospace technology

NASA Technical Reports Server (NTRS)

1993-01-01

Highlights of the Research Triangle Institute (RTI) Applications Team activities over the past quarter are presented in Section 1.0. The Team's progress in fulfilling the requirements of the contract is summarized in Section 2.0. In addition to our market-driven approach to applications project development, RTI has placed increased effort on activities to commercialize technologies developed at NASA Centers. These Technology Commercialization efforts are summarized in Section 3.0. New problem statements prepared by the Team in the reporting period are presented in Section 4.0. The Team's transfer activities for ongoing projects with the NASA Centers are presented in Section 5.0. Section 6.0 summarizes the status of four add-on tasks. Travel for the reporting period is described in Section 7.0. The RTI Team staff and consultants and their project responsibilities are listed in Appendix A. The authors gratefully acknowledge the contributions of many individuals to the RTI Technology Applications Team program. The time and effort contributed by managers, engineers, and scientists throughout NASA were essential to program success. Most important to the program has been a productive working relationship with the NASA Field Center Technology Utilization (TU) Offices. The RTI Team continues to strive for improved effectiveness as a resource to these offices. Industry managers, technical staff, medical researchers, and clinicians have been cooperative and open in their participation. The RTI Team looks forward to continuing expansion of its interaction with U.S. industry to facilitate the transfer of aerospace technology to the private sector.

Web-HLA and Service-Enabled RTI in the Simulation Grid

NASA Astrophysics Data System (ADS)

Huang, Jijie; Li, Bo Hu; Chai, Xudong; Zhang, Lin

HLA-based simulations in a grid environment have now become a main research hotspot in the M&S community, but there are many shortcomings of the current HLA running in a grid environment. This paper analyzes the analogies between HLA and OGSA from the software architecture point of view, and points out the service-oriented method should be introduced into the three components of HLA to overcome its shortcomings. This paper proposes an expanded running architecture that can integrate the HLA with OGSA and realizes a service-enabled RTI (SE-RTI). In addition, in order to handle the bottleneck problem that is how to efficiently realize the HLA time management mechanism, this paper proposes a centralized way by which the CRC of the SE-RTI takes charge of the time management and the dispatching of TSO events of each federate. Benchmark experiments indicate that the running velocity of simulations in Internet or WAN is properly improved.

Effects of the Monoamine Uptake Inhibitors RTI-112 and RTI-113 on Cocaine- and Food-Maintained Responding in Rhesus Monkeys

PubMed Central

SS, Negus; NK, Mello; HL, Kimmel; LL, Howell; FI, Carroll

2009-01-01

Cocaine blocks uptake of the monoamines dopamine, serotonin and norepinephrine, and monoamine uptake inhibitors constitute one class of drugs under consideration as candidate “agonist” medications for the treatment of cocaine abuse and dependence. The pharmacological selectivity of monoamine uptake inhibitors to block uptake of dopamine, serotonin and norepinephrine is one factor that may influence the efficacy and/or safety of these compounds as drug abuse treatment medications. To address this issue, the present study compared the effects of 7-day treatment with a non-selective monoamine uptake inhibitor (RTI-112) and a dopamine-selective uptake inhibitor (RTI-113) on cocaine- and food-maintained responding in rhesus monkeys. Monkeys (N=3) were trained to respond for cocaine injections (0.01 mg/kg/inj) and food pellets under a second-order schedule [FR2(VR16:S)] during alternating daily components of cocaine and food availability. Both RTI-112 (0.0032–0.01 mg/kg/hr) and RTI-113 (0.01–0.056 mg/kg/hr) produced dose-dependent, sustained and nearly complete elimination of cocaine self-administration. However, for both drugs, the potency to reduce cocaine self-administration was similar to the potency to reduce food-maintained responding. These findings do not support the hypothesis that pharmacological selectivity to block dopamine uptake is associated with behavioral selectivity to decrease cocaine- vs. food-maintained responding in rhesus monkeys. PMID:18755212

Discrete Boltzmann modeling of Rayleigh-Taylor instability in two-component compressible flows.

PubMed

Lin, Chuandong; Xu, Aiguo; Zhang, Guangcai; Luo, Kai Hong; Li, Yingjun

2017-11-01

A discrete Boltzmann model (DBM) is proposed to probe the Rayleigh-Taylor instability (RTI) in two-component compressible flows. Each species has a flexible specific-heat ratio and is described by one discrete Boltzmann equation (DBE). Independent discrete velocities are adopted for the two DBEs. The collision and force terms in the DBE account for the molecular collision and external force, respectively. Two types of force terms are exploited. In addition to recovering the modified Navier-Stokes equations in the hydrodynamic limit, the DBM has the capability of capturing detailed nonequilibrium effects. Furthermore, we use the DBM to investigate the dynamic process of the RTI. The invariants of tensors for nonequilibrium effects are presented and studied. For low Reynolds numbers, both global nonequilibrium manifestations and the growth rate of the entropy of mixing show three stages (i.e., the reducing, increasing, and then decreasing trends) in the evolution of the RTI. On the other hand, the early reducing tendency is suppressed and even eliminated for high Reynolds numbers. Relevant physical mechanisms are analyzed and discussed.

Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing.

PubMed

Rivera-Spoljaric, Katherine; Chinchilli, Vernon M; Camera, Lindsay J; Zeiger, Robert S; Paul, Ian M; Phillips, Brenda R; Taussig, Lynn M; Strunk, Robert C; Bacharier, Leonard B

2009-06-01

To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events. Parents (n = 238) of children age 12 to 59 months with moderate-to-severe intermittent wheezing enrolled in a year-long clinical trial completed surveys that captured signs and symptoms at the start of a respiratory tract illness (RTI). Sensitivity, specificity, negative predictive value, and positive predictive value (PPV) for each symptom leading to wheezing during that RTI were calculated. The most commonly reported first symptom categories during the first RTI were "nose symptoms" (41%), "significant cough" (29%), and "insignificant cough" (13%). The most reliable predictor of subsequent wheezing was significant cough, which had a specificity of 78% and a PPV of 74% for predicting wheezing. Significant cough is the most reliable antecedent of wheezing during an RTI. It may be useful to consider individualized symptom patterns as a component of management plans intended to minimize wheezing episodes.

Weaknesses and capacities affecting the Prehospital emergency care for victims of road traffic incidents in the greater Kampala metropolitan area: a cross-sectional study.

PubMed

Balikuddembe, Joseph Kimuli; Ardalan, Ali; Khorasani-Zavareh, Davoud; Nejati, Amir; Raza, Owais

2017-10-03

Pre-hospital emergency care is a vital and integral component of health systems particularly in the resource constrained countries like Uganda. It can help to minimize deaths, injuries, morbidities, disabilities and trauma caused by the road traffic incidents (RTIs). This study identifies the weaknesses and capacities affecting the pre-hospital emergency care for the victims of RTIs in the Greater Kampala Metropolitan Area (GKMA). A cross-sectional study was conducted in the GKMA using a three-part structured questionnaire. Data related to the demographics, nature of RTIs and victims' pre-hospital experience and existing Emergency Medical Services (EMS) were collected from victims and EMS specialists in 3 hospitals and 5 EMS institutions respectively. Data was descriptively analyzed, and after the principal component analysis was employed to identify the most influential weaknesses and capacities affecting the pre-hospital emergency care for the victims of RTI in the GKMA. From 459 RTI victims (74.7% males and 25.3% females) and 23 EMS specialists (91.3% males and 8.7% females) who participated in the study between May and June 2016, 4 and 5 key weaknesses and capacities respectively were identified to affect the pre-hospital emergency care for RTI victims in the GKMA. Although some strengths exist like ambulance facilitation, EMS structuring, coordination and others), the key weaknesses affecting the pre-hospital care for victims were noted to relate to absence of predefined EMS systems particularly in the GKMA and Uganda as a whole. They were identified to involve poor quality first aid treatment; insufficient skills/training of the first responders; inadequate EMS resources; and avoidable delays to respond and transport RTI victims to medical facilities. Though some strengths exist, the weaknesses affecting prehospital care for RTI victims primarily emanate from the absence of predefined and well-organized EMS systems in the GKMA and Uganda as a whole.

Characterizing molecular probes for diffusion measurements in the brain

PubMed Central

Kaur, Gurjinder; Hrabetova, Sabina; Guilfoyle, David N.; Nicholson, Charles; Hrabe, Jan

2008-01-01

Brain diffusion properties are at present most commonly evaluated by magnetic resonance (MR) diffusion imaging. MR cannot easily distinguish between the extracellular and intracellular signal components, but the older technique of Real-Time Iontophoresis (RTI) detects exclusively extracellular diffusion. Interpretation of the MR results would therefore benefit from auxiliary RTI measurements. This requires a molecular probe detectable by both techniques. Our aim was to specify a minimum set of requirements that such a diffusion probe should fulfill and apply it to two candidate probes: the cation tetramethylammonium (TMA+), used routinely in the RTI experiments, and the anion hexafluoroantimonate (SbF6−). Desirable characteristics of a molecular diffusion probe include predictable diffusion properties, stability, minimum interaction with cellular physiology, very slow penetration into the cells, and sufficiently strong and selective MR and RTI signals. These properties were evaluated using preparations of rat neocortical slices under normal and ischemic conditions, as well as solutions and agarose gel. While both molecules can be detected by MR and RTI, neither proved an ideal candidate. TMA+ was very stable but it penetrated into the cells and accumulated there within tens of minutes. SbF6− did not enter the cells as readily but it was not stable, particularly in ischemic tissue and at higher temperatures. Its presence also resulted in a decreased extracellular volume. These probe properties help to interpret previously published MR data on TMA+ diffusion and might play a role in other diffusion experiments obtained with them. PMID:18466980

2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter

PubMed Central

Hiranita, Takato; Wilkinson, Derek S.; Hong, Weimin C.; Zou, Mu-Fa; Kopajtic, Theresa A.; Soto, Paul L.; Lupica, Carl R.; Newman, Amy H.

2014-01-01

The present study examined RTI-371 [3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)-isoxazol-5-yl]tropane], a phenyltropane cocaine analog with effects distinct from cocaine, and assessed potential mechanisms for those effects by comparison with its constitutional isomer, RTI-336 [3β-(4-chlorophenyl)-2β-[3-(4-methylphenyl)-isoxazol-5-yl]tropane]. In mice, RTI-371 was less effective than cocaine and RTI-336 in stimulating locomotion, and incompletely substituted (∼60% maximum at 5 minutes or 1 hour after injection) in a cocaine (10 mg/kg i.p.)/saline discrimination procedure; RTI-336 completely substituted. In contrast to RTI-336, RTI-371 was not self-administered, and its pretreatment (1.0–10 mg/kg i.p.) dose-dependently decreased maximal cocaine self-administration more potently than food-maintained responding. RTI-336 pretreatment dose-dependently left-shifted the cocaine self-administration dose-effect curve. Both RTI-336 and RTI-371 displaced [3H]WIN35,428 [[3H](−)-3β-(4-fluorophenyl)-tropan-2β-carboxylic acid methyl ester tartrate] binding to striatal dopamine transporters (DATs) with Ki values of 10.8 and 7.81 nM, respectively, and had lower affinities at serotonin or norepinephrine transporters, or muscarinic and σ receptors. The relative low affinity at these sites suggests the DAT as the primary target of RTI-371 with minimal contributions from these other targets. In biochemical assays probing the outward-facing DAT conformation, both RTI-371 and RTI-336 had effects similar to cocaine, suggesting little contribution of DAT conformation to the unique pharmacology of RTI-371. The locomotor-stimulant effects of RTI-371 (3.0–30 mg/kg i.p.) were comparable in wild-type and knockout cannabinoid CB1 receptor (CB1R) mice, indicating that previously reported CB1 allosteric effects do not decrease cocaine-like effects of RTI-371. DAT occupancy in vivo was most rapid with cocaine and least with RTI-371. The slow apparent association rate may allow compensatory actions that in turn dampen cocaine-like stimulation, and give RTI-371 its unique pharmacologic profile. PMID:24518035

Response to Intervention (RTI) Services: An Ecobehavioral Perspective

ERIC Educational Resources Information Center

Greenwood, Charles R.; Kim, Joung Min

2012-01-01

Schoolwide Response to Intervention (RTI) services are growing in prevalence in U.S. schools. Most advanced are RTI programs in elementary schools, with preschool and secondary education programs beginning to discuss, develop, and experiment with schoolwide RTI. At its heart, RTI seeks to account for individual differences in student learning…

Dopamine transporter occupancy by RTI-55 determined using labeled cocaine, and displacement of RTI-55 with unlabeled cocaine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gatley, S.J.; Volkow, N.D.; Fowler, J.S.

We have previously visualized dopamine transporters (DAT) in human and baboon striatum using PET and C-11 cocaine. Cocaine analogs such as 3{beta}-(4-iodophenyl) tropane-2{beta}-carboxylic acid methyl ester (RTI-55 or {beta}CIT) with a higher affinity for the DAT may be potentially useful in interfering with cocaine`s actions in brain. We evaluated the time course of the effects of RTI-55 on C-11 cocaine binding in baboon brain prior to and 90 minutes, 24 hours, 4-5 days and 11-13 days after RTI-55(0.3 mg/kg iv). RTI-55 significantly inhibited C-11 cocaine binding at 90 minutes and 24 hours after administration. The half life for the clearancemore » of RTI-55 from the DAT was estimated to be 2 to 3 days in the baboon brain. Parallel studies with H-3 cocaine and RTI-55 (0.5 mg/kg iv or 2 mg/kg ip) were performed in mice, where RTI-55 significantly inhibited 5 minute striatum-to-cerebellium ratios (S/C) at 60 and 180 minutes after administration, and recovery was obtained at 12 hours. However, unlabeled cocaine (20 mg/Kg, i/p) given 60 minutes after RTI-55 led to a greater recovery of H-3 cocaine uptake measured at 180 minutes (S/C = 1.23 {plus_minus} 0.07, n= 5), than in control animals given saline after RTI-55 (S/C = 9.5{plus_minus}0.08). Animals given saline instead of RTI-55 had S/C = 1.45{plus_minus}0.04. These results document long lasting inhibition of cocaine binding by RTI-55 and corroborate the assumption that the binding kinetics of RTI-55 in striatum observed in SPECT imaging studies with I-123 RTI-55 represents binding to DAT`s. However, a pharmacological dose of cocaine is able to displace a fraction of the previously bound RTI-55 from the DAT. These findings have implications for drug development strategies for cocaine abuse.« less

To Wait in Tier 1 or Intervene Immediately: A Randomized Experiment Examining First-Grade Response to Intervention in Reading

ERIC Educational Resources Information Center

Al Otaiba, Stephanie; Connor, Carol M.; Folsom, Jessica S.; Wanzek, Jeanne; Greulich, Luana; Schatschneider, Christopher; Wagner, Richard K.

2014-01-01

This randomized controlled experiment compared the efficacy of two response-to-intervention (RTI) models--typical RTI and dynamic RTI--and included 34 first-grade classrooms (n = 522 students) across 10 socioeconomically and culturally diverse schools. Typical RTI was designed to follow the two-stage RTI decision rules that wait to assess response…

To Wait in Tier 1 or Intervene Immediately: A Randomized Experiment Examining First Grade Response to Intervention (RTI) in Reading.

PubMed

Al Otaiba, Stephanie; Connor, Carol M; Folsom, Jessica S; Wanzek, Jeanne; Greulich, Luana; Schatschneider, Christopher; Wagner, Richard K

2014-10-01

This randomized controlled experiment compared the efficacy of two Response to Intervention (RTI) models - Typical RTI and Dynamic RTI - and included 34 first-grade classrooms ( n = 522 students) across 10 socio-economically and culturally diverse schools. Typical RTI was designed to follow the two-stage RTI decision rules that wait to assess response to Tier 1 in many districts, whereas Dynamic RTI provided Tier 2 or Tier 3 interventions immediately according to students' initial screening results. Interventions were identical across conditions except for when intervention began. Reading assessments included letter-sound, word, and passage reading, and teacher-reported severity of reading difficulties. An intent-to-treat analysis using multi-level modeling indicated an overall effect favoring the Dynamic RTI condition ( d = .36); growth curve analyses demonstrated that students in Dynamic RTI showed an immediate score advantage, and effects accumulated across the year. Analyses of standard score outcomes confirmed that students in the Dynamic condition who received Tier 2 and Tier 3 ended the study with significantly higher reading performance than students in the Typical condition. Implications for RTI implementation practice and for future research are discussed.

To Wait in Tier 1 or Intervene Immediately: A Randomized Experiment Examining First Grade Response to Intervention (RTI) in Reading

PubMed Central

Al Otaiba, Stephanie; Connor, Carol M.; Folsom, Jessica S.; Wanzek, Jeanne; Greulich, Luana; Schatschneider, Christopher; Wagner, Richard K.

2014-01-01

This randomized controlled experiment compared the efficacy of two Response to Intervention (RTI) models – Typical RTI and Dynamic RTI - and included 34 first-grade classrooms (n = 522 students) across 10 socio-economically and culturally diverse schools. Typical RTI was designed to follow the two-stage RTI decision rules that wait to assess response to Tier 1 in many districts, whereas Dynamic RTI provided Tier 2 or Tier 3 interventions immediately according to students’ initial screening results. Interventions were identical across conditions except for when intervention began. Reading assessments included letter-sound, word, and passage reading, and teacher-reported severity of reading difficulties. An intent-to-treat analysis using multi-level modeling indicated an overall effect favoring the Dynamic RTI condition (d = .36); growth curve analyses demonstrated that students in Dynamic RTI showed an immediate score advantage, and effects accumulated across the year. Analyses of standard score outcomes confirmed that students in the Dynamic condition who received Tier 2 and Tier 3 ended the study with significantly higher reading performance than students in the Typical condition. Implications for RTI implementation practice and for future research are discussed. PMID:25530622

Response to Intervention and Students Who Are Deaf or Hard of Hearing

ERIC Educational Resources Information Center

Luckner, John; Pierce, Corey

2013-01-01

Students who are deaf or hard of hearing are increasingly being educated in regular education classrooms along with their typical hearing peers. Establishing educational environments that address their unique needs is essential for their success. Response to intervention (RtI), as it is being implemented in the United States, provides a framework…

Implementing School-Based Management in Indonesia. RTI Research Report Series. Occasional Paper

ERIC Educational Resources Information Center

Heyward, Mark; Cannon, Robert A.; Sarjono

2011-01-01

Indonesia, the world's fourth most populous nation, has been decentralizing its education sector for the past decade. In this context, school-based management is essential for improving the quality of education. A mixed-method, multisite assessment of a project that aimed to improve the management and governance of basic education in Indonesia…

Elementary School Psychologists and Response to Intervention (RTI)

ERIC Educational Resources Information Center

Little, Suzanne; Marrs, Heath; Bogue, Heidi

2017-01-01

The implementation of Response to Intervention (RTI) in elementary schools may have important implications for school psychologists. Therefore, it is important to better understand how elementary school psychologists perceive RTI and what barriers to successful RTI implementation they identify. Although previous research has investigated the…

Deep-tow studies of the Vema Fracture Zone: 1. Tectonics of a major slow slipping transform fault and its intersection with the Mid-Atlantic Ridge

NASA Astrophysics Data System (ADS)

MacDonald, Ken. C.; Castillo, David A.; Miller, Stephen P.; Fox, Paul J.; Kastens, Kim A.; Bonatti, Enrico

1986-03-01

The Vema transform fault, which slips at a rate of 24 mm/yr, displaces the Mid-Atlantic Ridge (MAR) 320 km in a left-lateral sense. High-resolution deep-tow studies of the Vema ridge-transform intersection (RTI) and the eastern 130 km of the active transform fault reveal a complex pattern of dip-slip and strike-slip faults which evolve in time and space. At the intersection, both the neovolcanic zone and the west wall of the MAR rift valley curve counterclockwise toward the transform fault along trends approximately 30° oblique to the regional north-south trend of the spreading axis. The curving of extensional structures in the rift valley, such as normal faults and the axial zone of dike injection, appears to be related to transmission of transform related shear stresses into the spreading center domain. Intermittent locking of the American and African lithospheric plates across the RTI causes shear stresses to penetrate up to 4 km into the MAR axial neovolcanic zone where the lithosphere is relatively thin and up to 12 km into the block-faulted west wall of the rift valley where the lithosphere is thicker. The degree of shear coupling across the RTI may vary with time due to changes in the thickness of the lithosphere along the axis (0-10 km), the strength of a "mantle weld" at depth, and the presence or absence of an axial magma chamber, so that extensional structures at the RTI may be either spreading center parallel when coupling is weak or oblique when coupling is strong. Oblique extension across the RTI in addition to other factors may account for some of the down dropping of lithosphere within the deep nodal basin. The easternmost 20 km of the active transform fault zone near the RTI displays a braided network of three to nine tectonically active grabens and V-shaped furrows in a zone 2-4 km wide, interpreted to consist of interwoven Riedel shears, P shears, and oblique normal faults. Clay cake deformation experiments and deep-tow observations suggest that P shears and R shears, which are 10°-20° oblique to the transform slip direction, develop during the initial stages of transform faulting near the RTI as the newly accreted lithosphere accelerates to full plate velocity. Some of the R shears propagate along strike and intercept the oblique normal faults resulting in sharply curving scarps at the RTI. Subsequent to this merging of the two fault types, some of the R shears develop a significant component of dip slip, while other R shears merge with P shears creating a complex anastomosing fault pattern up to 4 km wide. A continuous strand within this braided pattern of faults is interpreted to be the principal transform displacement zone near the RTI. Twenty kilometers west of the RTI the active transform fault zone narrows to a furrow generally less than 100 m wide with only a few short discontinuous splays. This narrow groove cuts through thinly sedimented basalt 20-40 km west of the RTI and continues as a narrow furrow (less than 100 m wide) through up to 1.5 km of layered turbidite fill most of the way to the western RTI. Such a narrow zone of deformation typifies the mature stages of transform faulting where the lithosphere on both sides of the transform fault is relatively old, thick, and rigid and has completed its acceleration to full plate velocity. The transform fault zone is closely associated with a partially buried median ridge and widens to 1-2 km where it transects exposed portions of the ridge. The transform parallel median and transverse ridges create the highest topography associated with the transform fault and may be serpentinized ultramafic intrusions capped by displaced crustal blocks of gabbro, metagabbro, and basalt.

Pattern of Road Traffic Injuries in Rural Bangladesh: Burden Estimates and Risk Factors.

PubMed

Ul Baset, Md Kamran; Rahman, Aminur; Alonge, Olakunle; Agrawal, Priyanka; Wadhwaniya, Shirin; Rahman, Fazlur

2017-11-07

Globally, road traffic injury (RTI) causes 1.3 million deaths annually. Almost 90% of all RTI deaths occur in low- and middle-income countries. RTI is one of the leading causes of death in Bangladesh; the World Health Organization estimated that it kills over 21,000 people in the country annually. This study describes the current magnitude and risk factors of RTI for different age groups in rural Bangladesh. A household census was carried out in 51 unions of seven sub-districts situated in the north and central part of Bangladesh between June and November 2013, covering 1.2 million individuals. Trained data collectors collected information on fatal and nonfatal RTI events through face-to-face interviews using a set of structured pre-tested questionnaires. The recall periods for fatal and non-fatal RTI were one year and six months, respectively. The mortality and morbidity rates due to RTI were 6.8/100,000 population/year and 889/100,000 populations/six months, respectively. RTI mortality and morbidity rates were significantly higher among males compared to females. Deaths and morbidities due to RTI were highest among those in the 25-64 years age group. A higher proportion of morbidity occurred among vehicle passengers (34%) and pedestrians (18%), and more than one-third of the RTI mortality occurred among pedestrians. Twenty percent of all nonfatal RTIs were classified as severe injuries. RTI is a major public health issue in rural Bangladesh. Immediate attention is needed to reduce preventable deaths and morbidities in rural Bangladesh.

Understanding RTI in Mathematics: Proven Methods and Applications

ERIC Educational Resources Information Center

Gersten, Russell, Ed.; Newman-Gonchar, Rebecca, Ed.

2011-01-01

Edited by National Math Panel veteran Russell Gersten with contributions by all of the country's leading researchers on RTI and math, this cutting-edge text blends the existing evidence base with practical guidelines for RTI implementation. Current and future RTI coordinators, curriculum developers, math specialists, and department heads will get…

Handbook of Response to Intervention: The Science and Practice of Multi-Tiered Systems of Support, 2nd Edition

ERIC Educational Resources Information Center

Jimerson, Shane R., Ed.; Burns, Matthew K., Ed.; VanDerHeyden, Amanda M., Ed.

2016-01-01

The second edition of this essential handbook provides a comprehensive, updated overview of the science that informs best practices for the implementation of response to intervention (RTI) processes within Multi-Tiered Systems of Support (MTSS) to facilitate the academic success of all students. The volume includes insights from leading scholars…

The Significance of the Response to Intervention Model on Elementary Reading Performance in Missouri

ERIC Educational Resources Information Center

Harrison, Philip L.

2017-01-01

The purpose of this study is to ascertain the essential elements of Response to Intervention programs among 150 high performing Title I schools with high rates of poverty as measured by free/reduced lunch participation rates. Response to Intervention (RTI) is a nationally-known instructional model used to assist students who are struggling to…

Effects of a Multitier Support System on Calculation, Word Problem, and Prealgebraic Performance Among At-Risk Learners.

PubMed

Powell, Sarah R; Fuchs, Lynn S; Cirino, Paul T; Fuchs, Douglas; Compton, Donald L; Changas, Paul C

2015-07-01

The focus of the present study was enhancing word-problem and calculation achievement in ways that support pre-algebraic thinking among 2 nd -grade students at risk for mathematics difficulty. Intervention relied on a multi-tier support system (i.e., responsiveness-to-intervention or RTI) in which at-risk students participate in general classroom instruction and receive supplementary small-group tutoring. Participants were 265 students in 110 classrooms in 25 schools. Teachers were randomly assigned to 3 conditions: calculation RTI, word-problem RTI, and business-as-usual control. Intervention lasted 17 weeks. Multilevel modeling indicated that calculation RTI improved calculation but not word-problem outcomes; word-problem RTI enhanced proximal word-problem outcomes as well as performance on some calculation outcomes; and word-problem RTI provided a stronger route than calculation RTI to pre-algebraic knowledge.

Effects of a Multitier Support System on Calculation, Word Problem, and Prealgebraic Performance Among At-Risk Learners

PubMed Central

Powell, Sarah R.; Fuchs, Lynn S.; Cirino, Paul T.; Fuchs, Douglas; Compton, Donald L.; Changas, Paul C.

2014-01-01

The focus of the present study was enhancing word-problem and calculation achievement in ways that support pre-algebraic thinking among 2nd-grade students at risk for mathematics difficulty. Intervention relied on a multi-tier support system (i.e., responsiveness-to-intervention or RTI) in which at-risk students participate in general classroom instruction and receive supplementary small-group tutoring. Participants were 265 students in 110 classrooms in 25 schools. Teachers were randomly assigned to 3 conditions: calculation RTI, word-problem RTI, and business-as-usual control. Intervention lasted 17 weeks. Multilevel modeling indicated that calculation RTI improved calculation but not word-problem outcomes; word-problem RTI enhanced proximal word-problem outcomes as well as performance on some calculation outcomes; and word-problem RTI provided a stronger route than calculation RTI to pre-algebraic knowledge. PMID:26097244

Questions and Answers about RTI: A Guide to Success

ERIC Educational Resources Information Center

Moran, Heather; Petruzzelli, Anthony

2011-01-01

As Response-to-Intervention (RTI) models continue to attract a great deal of attention, school and district leaders need to understand the structures needed, the personnel required, the challenges faced, and rewards realized from RTI. "Questions and Answers About RTI: A Guide to Success" is designed to guide a school or district through the…

Planning for RtI

ERIC Educational Resources Information Center

Robins, Jennifer; Antrim, Patricia

2013-01-01

In 2004 the Individuals with Disabilities Education Act authorized funding for Response to Intervention (RtI) instruction in the United States. By 2011, 71 percent of school districts had adopted RtI (Institute of Education Sciences 2011). The goal of RtI is to provide personalized, just-in-time intervention in reading and math for students who…

Systemic Change for RTI: Key Shifts for Practice

ERIC Educational Resources Information Center

Kozleski, Elizabeth B.; Huber, Jennifer J.

2010-01-01

RTI has the potential to meet the challenges of increasing diversity in student populations and the need for increasingly complex systems of instructional design. Three fundamental shifts in understanding systems and systems change must ground RTI policy and implementation work. First, RTI must be seen as an activity system nested within a larger…

Stabilization of the Rayleigh-Taylor instability in quantum magnetized plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L. F.; Ye, W. H.; He, X. T.

2012-07-15

In this research, stabilization of the Rayleigh-Taylor instability (RTI) due to density gradients, magnetic fields, and quantum effects, in an ideal incompressible plasma, is studied analytically and numerically. A second-order ordinary differential equation (ODE) for the RTI including quantum corrections, with a continuous density profile, in a uniform external magnetic field, is obtained. Analytic expressions of the linear growth rate of the RTI, considering modifications of density gradients, magnetic fields, and quantum effects, are presented. Numerical approaches are performed to solve the second-order ODE. The analytical model proposed here agrees with the numerical calculation. It is found that the densitymore » gradients, the magnetic fields, and the quantum effects, respectively, have a stabilizing effect on the RTI (reduce the linear growth of the RTI). The RTI can be completely quenched by the magnetic field stabilization and/or the quantum effect stabilization in proper circumstances leading to a cutoff wavelength. The quantum effect stabilization plays a central role in systems with large Atwood number and small normalized density gradient scale length. The presence of external transverse magnetic fields beside the quantum effects will bring about more stability on the RTI. The stabilization of the linear growth of the RTI, for parameters closely related to inertial confinement fusion and white dwarfs, is discussed. Results could potentially be valuable for the RTI treatment to analyze the mixing in supernovas and other RTI-driven objects.« less

Ethnic, socioeconomic and geographical inequalities in road traffic injury rates in the Auckland region.

PubMed

Hosking, Jamie; Ameratunga, Shanthi; Exeter, Daniel; Stewart, Joanna; Bell, Andrew

2013-04-01

To describe ethnic, socioeconomic and geographical differences in road traffic injury (RTI) within Auckland, New Zealand's largest city. We analysed rates of RTI deaths and non-fatal hospital admissions using the New Zealand Mortality Collection and the National Minimum Data Set 2000-08. Poisson regression examined the association of age, gender, prioritised ethnicity and small area deprivation (New Zealand Index of Deprivation) with RTI rates, and RTI rates were mapped for 21 local board areas within the Auckland region. While RTI rates increased with levels of deprivation in all age groups, the gradient was steepest among children (9% increase/decile) and adults aged 25-64 years (11% increase/decile). In all age groups, RTI risk was highest among Māori. Pacific children had an elevated risk of RTI compared with the NZ European/Other group, but Pacific youth (15-24 years) and adults (25-64 years) had a lower risk. While RTI rates were generally higher for those living in rural local board areas, all but one local board in the southern Auckland urban area had among the highest rates. There are substantial ethnic, socioeconomic and geographic inequalities in RTI risk in the Auckland region, with high rates among Māori (all ages), Pacific children, people living in socioeconomically deprived neighbourhoods, the urban south and rural regions. To meet the vision of regional plans, road safety efforts must prioritise vulnerable communities at greatest risk of RTI, and implement and monitor the effectiveness of strategies that specifically include a focus on reducing inequalities in RTI rates. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

Implementing RtI with Gifted Students

ERIC Educational Resources Information Center

Coleman, Mary Ruth, Ed.; Johnsen, Susan K., Ed.

2012-01-01

"Implementing RtI With Gifted Students" shares how RtI can fit within the framework of gifted education programming models. This edited book will serve as a reference guide for those interested in learning more about RtI and how it might be effectively implemented to meet the needs of all gifted students. Chapters contributed by top gifted…

Implementing Response to Intervention in Title I Elementary Schools: A Quantitative Study of Teacher Response Relationships

ERIC Educational Resources Information Center

Webster, Katina F.

2012-01-01

General educators and special educators in Title I elementary schools perceive the relationships between principles of RTI and their state RTI framework, the implementation of RTI, and professional development received in RTI differently. A quantitative survey-based research methodology was employed including the use of Cronbach's alpha to…

What Every School Leader Needs to Know about RTI

ERIC Educational Resources Information Center

Searle, Margaret

2010-01-01

These days, Response to Intervention (RTI) is everywhere, and there are lots of claims about what RTI is and how to do it. At last, here's a book that helps you cut through the quackery and ensure that your approach to RTI represents the very best of what is known about assessment, instruction, and intervention. Author Margaret Searle provides you…

Response to Intervention (RtI) in Secondary Schools: A Comparison of the RtI Service Delivery Model

ERIC Educational Resources Information Center

Epler-Brooks, Pam L.

2011-01-01

This qualitative, collective case study researched how the Response to Intervention (RtI) service delivery model was used within the secondary educational environment in two Ohio schools. Areas researched included the type of professional development used to introduce and sustain RtI, the amount of administrative support, the use of universal…

A Case Analysis of an Elementary School's Implementation of Response to Intervention

ERIC Educational Resources Information Center

White, Richard B.; Polly, Drew; Audette, Robert H.

2012-01-01

The study provides an illustration of an elementary school's implementation of a model of Response to Intervention (RTI). The school was selected to be the pilot for RTI implementation within the district. The study employed interviews of all members of the school RTI Leadership Team and select members of the district-level RTI Leadership Team. An…

RTI and the Adolescent Reader: Responsive Literacy Instruction in Secondary Schools (Middle and High School). Language & Literacy Series Practitioners Bookshelf

ERIC Educational Resources Information Center

Brozo, William G.

2011-01-01

"RTI and the Adolescent Reader" focuses exclusively on Response to Intervention (RTI) for literacy at the secondary level. In this accessible guide, William Brozo defines RTI and explains why and how it is considered a viable intervention model for adolescent readers. He analyzes the authentic structural, political, cultural, and teacher…

Response to Intervention (RTI) in the Province of Saskatchewan

ERIC Educational Resources Information Center

Kemp-Koo, Debra; Claypool, Tim

2011-01-01

Response to Intervention (RTI) is at a beginning stage in the Saskatchewan province as well as in other parts of Canada. One needs only to enter RTI and the names of any of the Canadian provinces into any widely used search engine to see the marked difference in the availability of information about RTI when the Canadian provinces and individual…

Examining the Impact of IRIS-RTI Modules on Preservice Teachers' Knowledge of Response to Intervention in Reading

ERIC Educational Resources Information Center

Kuo, Nai-Cheng

2013-01-01

Changes in legislation and the policies of education (e.g., NCLB 2002, IDEA 2004), the potential benefits of response-to-intervention (RTI), and government funds to support early intervention have made RTI a prominent issue in current education. To prepare teachers for implementing RTI, there are several government-sponsored online professional…

DDS as middleware of the Southern African Large Telescope control system

NASA Astrophysics Data System (ADS)

Maartens, Deneys S.; Brink, Janus D.

2016-07-01

The Southern African Large Telescope (SALT) software control system1 is realised as a distributed control system, implemented predominantly in National Instruments' LabVIEW. The telescope control subsystems communicate using cyclic, state-based messages. Currently, transmitting a message is accomplished by performing an HTTP PUT request to a WebDAV directory on a centralised Apache web server, while receiving is based on polling the web server for new messages. While the method works, it presents a number of drawbacks; a scalable distributed communication solution with minimal overhead is a better fit for control systems. This paper describes our exploration of the Data Distribution Service (DDS). DDS is a formal standard specification, defined by the Object Management Group (OMG), that presents a data-centric publish-subscribe model for distributed application communication and integration. It provides an infrastructure for platform- independent many-to-many communication. A number of vendors provide implementations of the DDS standard; RTI, in particular, provides a DDS toolkit for LabVIEW. This toolkit has been evaluated against the needs of SALT, and a few deficiencies have been identified. We have developed our own implementation that interfaces LabVIEW to DDS in order to address our specific needs. Our LabVIEW DDS interface implementation is built against the RTI DDS Core component, provided by RTI under their Open Community Source licence. Our needs dictate that the interface implementation be platform independent. Since we have access to the RTI DDS Core source code, we are able to build the RTI DDS libraries for any of the platforms on which we require support. The communications functionality is based on UDP multicasting. Multicasting is an efficient communications mechanism with low overheads which avoids duplicated point-to-point transmission of data on a network where there are multiple recipients of the data. In the paper we present a performance evaluation of DDS against the current HTTP-based implementation as well as the historical DataSocket implementation. We conclude with a summary and describe future work.

Evaluation of Response to Intervention Practices for Elementary School Reading. NCEE 2016-4000

ERIC Educational Resources Information Center

Balu, Rekha; Zhu, Pei; Doolittle, Fred; Schiller, Ellen; Jenkins, Joseph; Gersten, Russell

2015-01-01

Response to Intervention (RtI) is a framework for collecting and using data to match students to interventions of varying intensity. This study examines the implementation of RtI in Grade 1-3 reading in 13 states during the 2011-12 school year, focusing on 146 schools that were experienced with RtI. Full implementation of the RtI framework in…

Investigating the Decision-Making of Response to Intervention (RtI) Teams within the School Setting

ERIC Educational Resources Information Center

Thur, Scott M.

2015-01-01

The purpose of this study was to measure decision-making influences within RtI teams. The study examined the factors that influence school personnel involved in three areas of RtI: determining which RtI measures and tools teams select and implement (i.e. Measures and Tools), evaluating the data-driven decisions that are made based on the…

Female reproductive tract infections: understandings and care seeking behaviour among women of reproductive age in Lagos, Nigeria

PubMed Central

2010-01-01

Background Reproductive tract infections (RTI's) are endemic in developing countries and entail a heavy toll on women. If untreated, RTI's can lead to adverse health outcomes such as infertility, ectopic pregnancy and increased vulnerability to transmission of the human immunodeficiency virus. It is also associated with adverse pregnancy outcomes. While RTI's and its sequelae abound in Nigeria, there is paucity of publications on the subject in the country. This study assessed the understandings and care seeking behavior with regards to RTI's among women of reproductive age in Lagos, Nigeria with the aim of improving awareness on the subject. Methods A descriptive cross sectional survey of women attending the gynaecological outpatient and family planning clinics of the Lagos State University Teaching Hospital was carried out between 1st June 2008 and 31st August 2008 using a pre-tested questionnaire. Data was analysed using the Epi-Info 3.5 statistical software of the Centre for Disease Control and Prevention, Atlanta U.S.A. Results Most of the respondents (77.2%) had heard of RTI's. Toilet was the most perceived mode of contracting RTI's (44.6%), followed by sexual intercourse and poor hygiene. Vaginal discharge was the commonest symptom of RTI's named while inability to get pregnant was the commonest named complication. Majority of the respondent's demonstrated poor overall knowledge of symptoms and complications of RTI"s. 37.4% of the respondents had experienced symptoms of RTI's in the preceding six months. Vaginal discharge was the commonest symptom reported (21.8%) and the majority of those who reported symptoms sought medical treatment. Government health centres were the most visited health facilities for treatment. Conclusion Even though most of the respondents have heard of RTI's and sought treatment when symptomatic, they demonstrated poor overall understanding of the subject. There is need to educate women on preventive strategies, as RTI's are often assymptomatic. PMID:20331888

Evaluation of Response to Intervention Practices for Elementary School Reading. Executive Summary. NCEE 2016-4000

ERIC Educational Resources Information Center

Balu, Rekha; Zhu, Pei; Doolittle, Fred; Schiller, Ellen; Jenkins, Joseph; Gersten, Russell

2015-01-01

Response to Intervention (RtI) is a framework for collecting and using data to match students to interventions of varying intensity. This study examines the implementation of RtI in Grade 1-3 reading in 13 states during the 2011-12 school year, focusing on 146 schools that were experienced with RtI. Full implementation of the RtI framework in…

To Wait in Tier 1 or Intervene Immediately: A Randomized Experiment Examining First Grade Response to Intervention (RTI) in Reading

ERIC Educational Resources Information Center

Al Otaiba, Stephanie; Connor, Carol M.; Folsom, Jessica S.; Wanzek, Jeanne; Greulich, Luana; Schatschneider, Christopher; Wagner, Richard K.

2015-01-01

This randomized control study compares the efficacy of two response-to-intervention (RTI) models: (1) Dynamic RTI, which immediately refers grade 1 students with the weakest skills to the most intensive intervention supports (Tier 2 or Tier 3); and (2) Typical RTI, which starts all students in Tier 1 and after 8 weeks, decides whether students who…

The influence of social support and perceived stress on response time inconsistency.

PubMed

Phibbs, Sandi; Stawski, Robert S; MacDonald, Stuart W S; Munoz, Elizabeth; Smyth, Joshua M; Sliwinski, Martin J

2017-11-24

Lack of social support and high levels of stress represent potentially modifiable risk factors for cognitive aging. In this study we examined the relationships between these two risk factors and response time inconsistency (RTI), or trial-to-trial variability in choice response time tasks. RTI is an early indicator of declining cognitive health, and examining the influence of modifiable psychosocial risk factors on RTI is important for understanding and promoting cognitive health during adulthood and old age. Using data from a community sample study (n = 317; M age = 49, range = 19-83), we examined the effects of social support, including size of network and satisfaction with support, global perceived stress, and their interactions on RTI. Neither size of network nor satisfaction with support was associated with RTI independent of perceived stress. Stress was positively associated with increased RTI on all tasks, independent of social support. Perceived stress did not interact with either dimension of social support to predict RTI, and perceived stress effects were invariant across age and sex. Perceived stress, but not social support, may be a unique and modifiable risk factor for normal and pathological cognitive aging. Discussion focuses on the importance of perceived stress and its impact on RTI in supporting cognitive health in adulthood and old age.

Evaluation of the Rotational Throttle Interface for Converting Aircraft Utilizing the NASA Ames Vertical Motion Simulator

NASA Technical Reports Server (NTRS)

Rozovski, David; Theodore, Colin R.

2011-01-01

An experiment was conducted to compare a conventional helicopter Thrust Control Lever (TCL) to the Rotational Throttle Interface (RTI) for tiltrotor aircraft. The RTI is designed to adjust its orientation to match the angle of the tiltrotor s nacelles. The underlying principle behind the design is to increase pilot awareness of the vehicle s configuration state (i.e. nacelle angle). Four test pilots flew multiple runs on seven different experimental courses. Three predominant effects were discovered in the testing of the RTI: 1. Unintentional binding along the control axis resulted in difficulties with precision power setting, 2. Confusion in which way to move the throttle grip was present during RTI transition modes, and 3. Pilots were not able to distinguish small angle differences during RTI transition. In this experiment the pilots were able to successfully perform all of the required tasks with both inceptors although the handling qualities ratings were slightly worse for the RTI partly due to unforeseen deficiencies in the design. Pilots did however report improved understanding of nacelle movement during transitions with the RTI.

Response to Intervention: Preventing and Remediating Academic Difficulties

PubMed Central

Fletcher, Jack M.; Vaughn, Sharon

2009-01-01

We address the advantages and challenges of service delivery models based on student response to intervention (RTI) for preventing and remediating academic difficulties and as data sources for identification for special education services. The primary goal of RTI models is improved academic and behavioral outcomes for all students. We review evidence for the processes underlying RTI, including screening and progress monitoring assessments, evidence-based interventions, and schoolwide coordination of multitiered instruction. We also discuss the secondary goal of RTI, which is to provide data for identification of learning disabilities (LDs). Incorporating instructional response into identification represents a controversial shift away from discrepancies in cognitive skills that have traditionally been a primary basis for LD identification. RTI processes potentially integrate general and special education and suggest new directions for research and public policy related to LDs, but the scaling issues in schools are significant and more research is needed on the use of RTI data for identification. PMID:21765862

Fatal road traffic injuries in Ibadan, using the mortuary as a data source.

PubMed

Eze, Uwom O; Kipsaina, Chebiwot Caroline; Ozanne-Smith, Joan

2013-12-01

Road Traffic Injury (RTI) in Africa represents 14% of global RTI deaths. Lack of timely, reliable data undermines road safety interventions. Available fatality data are aggregated, limited in detail or scarce in surveys. This is the first fatal RTI surveillance study in Nigeria. To pilot a systematic mortuary-based data collection in Ibadan, determine the nature and circumstances of fatal RTI and assess data quality against existing data sources. Using a draft data collection system developed jointly by WHO and Monash University, the detailed information was prospectively collected on RTI University College Hospital mortuary admissions in Ibadan September 2010 to February 2011. Demographics, road user type, counterpart vehicle, intent, manner and medical cause of death were recorded. Mortuary admissions included 80 fatal RTI cases: 81.3% males. By road user category, 28 (35.0%) were pedestrians; 28 (35.0%) motorised 2-wheeler users; 18.8% car occupants; and 11.3% bus occupants. In 70% of cases, medical cause of death was head injury, including 25 of 28 motorised 2-wheeler users (89.3%). Estimates from this study indicate apparent increased mortuary capture of fatal RTI compared with police data. This study demonstrates the feasibility of collecting detailed, timely RTI fatality data through mortuary-based surveillance in Ibadan. While not all RTI deaths are reported to any authority in Ibadan, this large case series complements existing data sources and suggests that pedestrians and motorised 2-wheeler users die most often in road traffic crashes. Frequent head injuries among motorised 2-wheeler users strongly support the need for helmet wearing interventions.

AAC and RTI: building classroom-based strategies for every child in the classroom.

PubMed

Grether, Sandra M; Sickman, Linda Sue

2008-05-01

Educators were previously encouraged to use IQ-achievement discrepancy to identify children with learning disabilities. The Individuals with Disabilities Education Improvement Act promotes an alternative method, response to intervention, or RTI, not only to identify these children but also to provide early intervention to all children at risk for school failure. Children with complex communication needs who use augmentative and alternative communication (AAC) are at risk for failure in the classroom and can benefit from the educational supports provided through RTI. This article discusses the levels of support provided by RTI, the speech-language pathologist's role in RTI, and strategies and supports for achieving academic success for children who use AAC.

Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine.

PubMed

Ranaldi, R; Anderson, K G; Carroll, F I; Woolverton, W L

2000-12-01

The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a monoamine uptake blocker would block behavioral effects of MA related to its abuse. RTI 111, a newly synthesized 3-phenyltropane analog with high affinity for the dopamine, norepinephrine, and serotonin transporters, was evaluated alone and in combination with MA for its ability to block the reinforcing and discriminative stimulus effects of MA in rhesus monkeys. RTI 111 (0.0003-0.03 mg/kg, i.v.) was made available to four rhesus monkeys for self-administration under a fixed-ratio 25 (FR 25) schedule of reinforcement. RTI 111 (0.01-0.1 mg/kg, i.m.) was also administered as a pretreatment (15 min prior) to four monkeys self-administering MA (0.0-0.3 mg/kg per injection, i.v.) on a progressive-ratio schedule of reinforcement. MA (0.01-1.0 mg/kg, i.m.), RTI 111 (0.001-0.1 mg/kg, i.m.), or the combination of MA and RTI 111 were administered to four monkeys trained to discriminate (+)-amphetamine (AMPH; 1.0 or 1.7 mg/kg, intragastric) from saline. When RTI 111 was made available for self-administration under an FR 25 schedule it functioned as a positive reinforcer in all four monkeys tested. When RTI 111 was given as a pretreatment to monkeys self-administering MA under a progressive-ratio schedule, the MA dose-response function shifted to the left and down. When RTI 111 or MA were given to monkeys trained to discriminate AMPH from saline, full AMPH-like responding was observed for both drugs. Given in combination, RTI 111 shifted the MA dose-response function to the left. These data suggest that RTI 111 is behaviorally similar to traditional psychomotor stimulants that act at the DA transporter and that it increases, rather than blocks, the behavioral potency of MA.

Road use pattern and risk factors for non-fatal road traffic injuries among children in urban India

PubMed Central

Dandona, Rakhi; Anil Kumar, G.; Ameratunga, Shanthi; Dandona, Lalit

2011-01-01

Objective We assessed the road use pattern and incidence and risk factors of non-fatal road traffic injuries (RTI) among children aged 5–14 years in Hyderabad, India. Methods In a cross-sectional population-based survey, data were collected on 2809 participants aged 5–14 years (98.4% participation) selected using multi-stage cluster sampling. Participants recalled non-fatal RTI during the previous 3 and 12 months. RTI was defined as an injury resulting from a road traffic crash irrespective of severity and outcome. Results Boys (11.5) had a higher mean number of road trips per day than girls (9.6), and the latter were more likely to walk and less likely to use a cycle (p < 0.001). With increasing household income quartile, the proportion of trips using cycles or motorised two-wheeled vehicles increased while trips as pedestrians decreased (p < 0.001). Based on the 3-month recall period, the age-sex-adjusted annual rate of RTI requiring recovery period of >7 days was 5.8% (95% CI 4.9–6.6). Boys and girls had similar RTI rates as pedestrians but boys had a three times higher rate as cyclists. Considering the most recent RTI in the last 12 months, children of the highest household income quartile were significantly less likely to sustain pedestrian RTI (0.26, 95% CI 0.08–0.86). The odds of overall RTI were significantly higher for those who rode a cycle (2.45, 95% CI 1.75–3.42) and who currently drove a motorised two-wheeled vehicle (2.83, 95% CI 1.60–5.00). Conclusion These findings can assist in planning appropriate road safety initiatives to reduce cycle and pedestrian RTI among children to reduce RTI burden in India. PMID:21584975

Cognitively-Impaired-Not-Demented Status Moderates the Time-Varying Association between Finger Tapping Inconsistency and Executive Performance.

PubMed

Halliday, Drew W R; Stawski, Robert S; MacDonald, Stuart W S

2017-02-01

Response time inconsistency (RTI) in cognitive performance predicts deleterious health outcomes in late-life; however, RTI estimates are often confounded by additional influences (e.g., individual differences in learning). Finger tapping is a basic sensorimotor measure largely independent of higher-order cognition that may circumvent such confounds of RTI estimates. We examined the within-person coupling of finger-tapping mean and RTI on working memory, and the moderation of these associations by cognitive status. A total of 262 older adults were recruited and classified as controls, cognitively-impaired-not-demented (CIND) unstable or CIND stable. Participants completed finger-tapping and working-memory tasks during multiple weekly assessments, repeated annually for 4 years. Within-person coupling estimates from multilevel models indicated that on occasions when RTI was greater, working-memory response latency was slower for the CIND-stable, but not for the CIND-unstable or control individuals. The finger-tapping task shows potential for minimizing confounds on RTI estimates, and for yielding RTI estimates sensitive to central nervous system function and cognitive status. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

NASA Technology Applications Team: Commercial applications of aerospace technology

NASA Technical Reports Server (NTRS)

1994-01-01

The Research Triangle Institute (RTI) Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies, that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. The RTI Team has been successful in the development of NASA/industry partnerships and commercialization of NASA technologies. RTI ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed and implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs. (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology. And (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994.

NASA Technology Applications Team: Commercial applications of aerospace technology

NASA Technical Reports Server (NTRS)

1994-01-01

The Research Triangle Institute (RTI) is pleased to report the results of NASA contract NASW-4367, 'Operation of a Technology Applications Team'. Through a period of significant change within NASA, the RTI Team has maintained its focus on helping NASA establish partnerships with U.S. industry for dual use development and technology commercialization. Our emphasis has been on outcomes, such as licenses, industry partnerships and commercialization of technologies that are important to NASA in its mission of contributing to the improved competitive position of U.S. industry. RTI's ongoing commitment to quality and customer responsiveness has driven our staff to continuously improve our technology transfer methodologies to meet NASA's requirements. For example, RTI has emphasized the following areas: (1) Methodology For Technology Assessment and Marketing: RTI has developed an implemented effective processes for assessing the commercial potential of NASA technologies. These processes resulted from an RTI study of best practices, hands-on experience, and extensive interaction with the NASA Field Centers to adapt to their specific needs; (2) Effective Marketing Strategies: RTI surveyed industry technology managers to determine effective marketing tools and strategies. The Technology Opportunity Announcement format and content were developed as a result of this industry input. For technologies with a dynamic visual impact, RTI has developed a stand-alone demonstration diskette that was successful in developing industry interest in licensing the technology; and (3) Responsiveness to NASA Requirements: RTI listened to our customer (NASA) and designed our processes to conform with the internal procedures and resources at each NASA Field Center and the direction provided by NASA's Agenda for Change. This report covers the activities of the Research Triangle Institute Technology Applications Team for the period 1 October 1993 through 31 December 1994.

Implementing RTI[superscript 2]: Reports from the Field. Policy Brief

ERIC Educational Resources Information Center

Dawkins, Shardae

2014-01-01

Starting in 2014-15, districts across the state of Tennessee must implement a Response to Instruction and Intervention (RTI[superscript 2]) plan. RTI[superscript 2] is an instructional framework which provides ongoing monitoring of student performance and progress through the use of universal student screeners and interventions targeted at…

Practical Applications of Response-to-Intervention Research

ERIC Educational Resources Information Center

Griffiths, Amy-Jane; VanDerHeyden, Amanda M.; Parson, Lorien B.; Burns, Matthew K.

2006-01-01

Several approaches to response to intervention (RTI) described in the literature could be blended into an RTI model that would be effective in the schools. An effective RTI model should employ three fundamental variables: (a) systematic data collection to identify students in need, (b) effective implementation of interventions for adequate…

Perceptions of School Psychologists Regarding Barriers to Response to Intervention (RTI) Implementation

ERIC Educational Resources Information Center

Marrs, Heath; Little, Suzanne

2014-01-01

As Response to Intervention (RTI) models continue to be implemented, an important research question is how school psychologists are experiencing the transition to RTI practice. In order to better understand the experiences of school psychologists, interviews with seven practicing school psychologists regarding their perceptions of barriers and…

A Quantitative Examination of School Leadership and Response to Intervention

ERIC Educational Resources Information Center

Maier, Michael P.; Pate, James L.; Gibson, Nicole M.; Hilgert, Larry; Hull, Karla; Campbell, Patti C.

2016-01-01

This study sought to provide educational researchers, policy-makers, and professionals with quantitative data on the status of RTI implementation, as well as on which leadership behaviors have been associated with successful implementation. School psychologists and other RTI professionals rated their schools on RTI implementation using the RTI…

Critical Questions about Mathematics RTI

ERIC Educational Resources Information Center

Allsopp, David; Hoppey, David

2011-01-01

The effective implementation of response to intervention (RTI) at the secondary level is proving to be especially challenging for school leaders. The structure of secondary schools and the complexity and depth of the secondary curriculum can complicate the integration of RTI across specific content areas. The purpose of this article is to give…

Development of a prognostic model based on demographic, environmental and lifestyle information for predicting incidences of symptomatic respiratory or gastrointestinal infection in adult office workers.

PubMed

Hovi, Tapani; Ollgren, Jukka; Haapakoski, Jaason; Savolainen-Kopra, Carita

2016-11-16

Occurrence of respiratory tract infection (RTI) or gastrointestinal tract infection (GTI) is known to vary between individuals and may be a confounding factor in the analysis of the results of intervention trials. We aimed at developing a prognostic model for predicting individual incidences of RTI and GTI on the basis of data collected in a hand-hygiene intervention trial among adult office workers, and comprising a prior-to-onset questionnaire on potential infection-risk factors and weekly electronic follow-up reports on occurrence of symptoms of, and on exposures to RTI or GTI. A mixed-effect negative binomial regression model was used to calculate a predictor-specific incidence rate ratio for each questionnaire variable and for each of the four endpoints, and predicted individual incidences for symptoms of and exposures to RTI and GTI. In the fitting test these were then compared with the observed incidences. Out of 1270 eligible employees of six enterprises, 683 volunteered to participate in the trial. Ninety-two additional participants were recruited during the follow-up. Out of the 775 registered participants, 717 returned the questionnaire with data on potential predictor variables and follow-up reports for determination of outcomes. Age and gender were the strongest predictors of both exposure to, and symptoms of RTI or GTI, although no gender difference was seen in the RTI incidence. In addition, regular use of public transport, and history of seasonal influenza vaccination increased the risk of RTI. The individual incidence values predicted by the model showed moderate correlation with those observed in each of the four categories. According to the Cox-Snell multivariate formula the model explained 11.2% of RTI and 3.3% of GTI incidences. Resampling revealed mean and 90% confidence interval values of 10.9 (CI 6.9-14.5)% for RTI and 2.4 (0.6-4.4)% for GTI. The model created explained a relatively small proportion of the occurrence of RTI or GTI. Unpredictable exposure to disease agents, and individual susceptibility factors are likely to be key determinants of disease emergence. Yet, the model might be useful in prerandomization stratification of study population in RTI intervention trials where the expected difference between trial arms is relatively small. Registered at ClinicalTrials.gov with Identifier NCT00821509 on 12 March 2009.

Comparison of polymerase chain reaction methods and plating for analysis of enriched cultures of Listeria monocytogenes when using the ISO11290-1 method.

PubMed

Dalmasso, Marion; Bolocan, Andrei Sorin; Hernandez, Marta; Kapetanakou, Anastasia E; Kuchta, Tomáš; Manios, Stavros G; Melero, Beatriz; Minarovičová, Jana; Muhterem, Meryem; Nicolau, Anca Ioana; Rovira, Jordi; Skandamis, Panagiotis N; Stessl, Beatrix; Wagner, Martin; Jordan, Kieran; Rodríguez-Lázaro, David

2014-03-01

Analysis for Listeria monocytogenes by ISO11290-1 is time-consuming, entailing two enrichment steps and subsequent plating on agar plates, taking five days without isolate confirmation. The aim of this study was to determine if a polymerase chain reaction (PCR) assay could be used for analysis of the first and second enrichment broths, saving four or two days, respectively. In a comprehensive approach involving six European laboratories, PCR and traditional plating of both enrichment broths from the ISO11290-1 method were compared for the detection of L. monocytogenes in 872 food, raw material and processing environment samples from 13 different dairy and meat food chains. After the first and second enrichments, total DNA was extracted from the enriched cultures and analysed for the presence of L. monocytogenes DNA by PCR. DNA extraction by chaotropic solid-phase extraction (spin column-based silica) combined with real-time PCR (RTi-PCR) was required as it was shown that crude DNA extraction applying sonication lysis and boiling followed by traditional gel-based PCR resulted in fewer positive results than plating. The RTi-PCR results were compared to plating, as defined by the ISO11290-1 method. For first and second enrichments, 90% of the samples gave the same results by RTi-PCR and plating, whatever the RTi-PCR method used. For the samples that gave different results, plating was significantly more accurate for detection of positive samples than RTi-PCR from the first enrichment, but RTi-PCR detected a greater number of positive samples than plating from the second enrichment, regardless of the RTi-PCR method used. RTi-PCR was more accurate for non-food contact surface and food contact surface samples than for food and raw material samples especially from the first enrichment, probably because of sample matrix interference. Even though RTi-PCR analysis of the first enrichment showed less positive results than plating, in outbreak scenarios where a rapid result is required, RTi-PCR could be an efficient way to get a preliminary result to be then confirmed by plating. Using DNA extraction from the second enrichment broth followed by RTi-PCR was reliable and a confirmed result could be obtained in three days, as against seven days by ISO11290-1. Copyright © 2014 Elsevier B.V. All rights reserved.

Presenting a practical model for governmental political mapping on road traffic injuries in Iran in 2008: a qualitative study.

PubMed

Ainy, E; Soori, Hamid; Mahfozphoor, S; Movahedinejad, Aa

2011-10-01

This study was conducted to assess political mapping in relation to road traffic injuries (RTIs) management and prevention to present a practical model for RTIs. A phenomenological qualitative study was developed to identify stakeholders on RTI in Iran in 2008. The designed questions were discussed by systematic discussion with the relevant specialists. After receiving written consent from the main responsible stakeholders, the questionnaire was filled in by trained experts. Themes were determined and content was analysed in each part. Main responsible stakeholders. By comparing other countries' political mappings which were found in the library and by Internet searching, political mapping of RTI in Iran was suggested. Subjects were 26 experts from governmental and non-governmental organizations. The main proposed leading agencies were traffic police and presidency (13% each). Findings showed that only 31% of our political mapping was formed according to the World Health Organization (WHO). In 94% of cases, the involved organizations had unspecified roles; the reason was poor monitoring for RTI in 39% of organizations. Lack of adequate authority and suitable legislation, appropriate laws and tasks definition were 94% and 18%, respectively. The most essential policy to overcome problems was defined as appropriate legislation (21%), and the most frequent type of support needed was mentioned as adequate budgeting (25%). Traffic police can play the leading agency role by government support, with strong leadership, appropriate legislation, defined tasks and adequate budget.

Middle School Reading Assessment: Measuring What Matters under a RTI Framework

ERIC Educational Resources Information Center

O'reilly, Tenaha; Sabatini, John; Bruce, Kelly; Pillarisetti, Srinivasa; McCormick, Carina

2012-01-01

This article presents a prototype reading assessment designed to measure and support component and integrated reading skills. The work is motivated by the need to create a new generation of assessments that are better aligned with the research in cognitive science, reading and learning. An assessment that synthesizes advances in these areas may…

Response to Intervention (RTI) for Students Presenting with Behavioral Difficulties: Culturally Responsive Guiding Questions

ERIC Educational Resources Information Center

Abou-Rjaily, Kathleen; Stoddard, Susan

2017-01-01

Response to Intervention (RTI) is a tiered intervention that assists school personnel in determining eligibility for special education services. Studies support the use of RTI as an early intervention for addressing significant learning disabilities (SLD) and social emotional behaviors, as well as for students who are culturally and linguistically…

Perspectives on Culturally and Linguistically Responsive RtI Pedagogics through a Cultural and Linguistic Lens

ERIC Educational Resources Information Center

Montalvo, Ricardo; Combes, Bertina H.; Kea, Cathy D.

2014-01-01

Response to intervention (RtI) originates from national legislation and critical research of evidence-based practices for low performing students and students at-risk of failing or receiving special education services. RtI proactively facilitates culturally and linguistically responsive pedagogy for culturally and linguistically diverse (CLD)…

A Comparison of Satisfaction Ratings of School Psychologists in RTI versus Non-RTI School Districts

ERIC Educational Resources Information Center

Bade-White, Priscilla A.

2012-01-01

Teachers' satisfaction with school psychological services has been studied for more than 30 years. Few to no studies, however, are available that provide data about the perceptions of school psychologists regarding their perceived value within different service delivery models, particularly those involving Response to Intervention (RTI) models.…

RTI Success: Proven Tools and Strategies for Schools and Classrooms

ERIC Educational Resources Information Center

Whitten, Elizabeth; Esteves, Kelli J.; Woodrow, Alice

2009-01-01

What is Response to Intervention (RTI) and how can it benefit your school? Find out in "RTI Success", an all-in-one resource that provides information on this innovative model as well as step-by-step administrator guidelines and practical teacher tools for implementation. Despite ongoing federal initiatives meant to increase the profile…

State Laws and Guidelines for RTI: Additional Implementation Features

ERIC Educational Resources Information Center

Zirkel, Perry A.

2011-01-01

Response to intervention (RTI) remains a major issue in both the professional literature and school practice. A series of previous "snapshot" studies traced the development of RTI in state laws concerning identification of students with specific learning disability (SLD). In the last article in this series, Zirkel and Thomas (2010) reported that…

A Critical Practice Analysis of Response to Intervention Appropriation in an Urban School

ERIC Educational Resources Information Center

King Thorius, Kathleen A.; Maxcy, Brendan D.; Macey, Erin; Cox, Adrienne

2014-01-01

This qualitative case study focuses on factors mediating an urban school's enactment of Response to Intervention (RTI). Over one school year, we (a) observed weekly RTI meetings, (b) debriefed observations weekly, (c) interviewed RTI team members, and (d) examined procedural documents. Analyses included post-observation debriefing and coding…

It's Not Your Grandmother's School: Leadership Decisions in RTI

ERIC Educational Resources Information Center

Whitelock, Sally

2010-01-01

As a practicing school psychologist and administrator at Brown International Academy, an inner city elementary school in Denver Public Schools, the author believes that if the RTI model is put into practice, it will greatly impact educational outcomes for all students. Putting RTI into practice is not easy. It requires individuals to think…

High Schools Try out RTI

ERIC Educational Resources Information Center

Samuels, Christina A.

2009-01-01

"Response to intervention" (RTI) as a model for boosting student achievement has taken off like wildfire. When it comes to research on how best to implement the process for students in middle and high school, though, the flame abruptly fizzles out. There's little RTI research that is specific to secondary schools, although it has been…

General Education Pre-Service Teachers' Levels of Concern on Response to Intervention (RTI) Implementation

ERIC Educational Resources Information Center

Barrio, Brenda L.; Combes, Bertina H.

2015-01-01

Revisions to Individuals with Disabilities Education Improvement Act (IDEIA) proposed alternative models, such as Response to Intervention (RTI), as a preventive measure that supports students at risk. As teachers' roles evolve in response to RTI, teacher preparation programs must adjust their focus and curriculum accordingly. A mixed-methods…

Dynamic Assessment and Response to Intervention

PubMed Central

Grigorenko, Elena L.

2013-01-01

This article compares and contrasts the main features of dynamic testing and assessment (DT/A) and response to intervention (RTI). The comparison is carried out along the following lines: (a) historical and empirical roots of both concepts, (b) premises underlying DT/A and RTI, (c) terms used in these concepts, (d) use of these concepts, (e) evidence in support of DT/A and RTI, and (f) expectations associated with each of the concepts. The main outcome of this comparison is a conclusion that both approaches belong to one family of methodologies in psychology and education whose key feature is in blending assessment and intervention in one holistic activity. Because DT/A has been around much longer than RTI, it makes sense for the proponents of RTI to consider both the accomplishments and frustrations that have accumulated in the field of DT/A. PMID:19073895

Smart RTI: A Next-Generation Approach to Multilevel Prevention

PubMed Central

FUCHS, DOUGLAS; FUCHS, LYNN S.; COMPTON, DONALD L.

2012-01-01

During the past decade, responsiveness to intervention (RTI) has become popular among many practitioners as a means of transforming schooling into a multilevel prevention system. Popularity aside, its successful implementation requires ambitious intent, a comprehensive structure, and coordinated service delivery. An effective RTI also depends on building-based personnel with specialized expertise at all levels of the prevention system. Most agree on both its potential for strengthening schooling and its heavy demand on practitioners. In this article, we describe Smart RTI, which we define as making efficient use of school resources while maximizing students' opportunities for success. In light of findings from recent research, we discuss three important features of Smart RTI: (a) multistage screening to identify risk, (b) multistage assessment to determine appropriate levels of instruction, and (c) a role for special education that supports prevention. PMID:22736805

The Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada.

PubMed

Lenoir-Wijnkoop, Irene; Gerlier, Laetitia; Roy, Denis; Reid, Gregor

2016-01-01

There is accumulating evidence supporting the use of probiotics, which are defined as "live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host", as a preventive measure against respiratory tract infections (RTI). Two recent meta-analyses showed probiotic consumption (daily intake of 107 to 1010 CFU in any form for up to 3 months) significantly reduced RTI duration, frequency, antibiotic use and work absenteeism. The aim of this study was to assess the impact of probiotic use in terms of number of RTI episodes and days averted, and the number of antibiotic prescriptions and missed workdays averted, in the general population of Canada. In addition, the corresponding economic impact from both a healthcare payer and a productivity perspective was estimated. A microsimulation model was developed to reproduce the Canadian population (sample rate of 1/1000 = 35 540 individuals) employing age and gender. RTI incidence was taken from FluWatch consultation rates for influenza-like illness (2013-14) and StatCan all-cause consultations statistics. The model was calibrated on a 2.1% RTI annual incidence in the general population (5.2 million RTI days) and included known risk factors (smoking status, shared living conditions and vaccination status). RTI-related antibiotic prescriptions and work absenteeism were obtained from the literature. The results indicate that probiotic use saved 573 000-2.3 million RTI-days, according to the YHEC-Cochrane scenarios respectively. These reductions were associated with an avoidance of 52 000-84 000 antibiotic courses and 330 000-500 000 sick-leave days. A projection of corresponding costs reductions amounted to Can$1.3-8.9 million from the healthcare payer perspective and Can$61.2-99.7 million when adding productivity losses. The analysis shows that the potential of probiotics to reduce RTI-related events may have a substantial clinical and economic impact in Canada.

School Area Road Safety Assessment and Improvements (SARSAI) programme reduces road traffic injuries among children in Tanzania.

PubMed

Poswayo, Ayikai; Kalolo, Simon; Rabonovitz, Katheryn; Witte, Jeffrey; Guerrero, Alejandro

2018-05-19

To determine the impact of a paediatric road traffic injury (RTI) prevention programme in urban Sub-Saharan Africa. Dares Salaam, Republic of Tanzania. Household surveys were conducted in catchment areas around 18 primary schools in Dar es Salaam, Republic of Tanzania; the catchment areas were divided into control and intervention groups. Collected data included basic demographic information on all school-aged household members and whether or not they had been involved in an RTI in the previous 12 months, and, if so, what the characteristics of that RTI were. Based on these findings, a separate road safety engineering site analysis and consultation with the communities and other stakeholders, an injury-prevention programme was developed and implemented, consisting of infrastructure enhancements and a site-specific educational programme. The programme was initially implemented at the intervention schools. After 1 year, data were collected in the same manner. The control group received the same intervention after follow-up data were collected. Data were collected on 12 957 school-aged children in the baseline period and 13 555 school-aged children in the post-intervention period, in both the control and intervention communities. There was a statistically significant reduction in RTIs in the intervention group and a non-significant increase in RTI in the control group. The greatest reduction was in motorcycle-pedestrian RTI, private vehicle-pedestrian RTI and morning RTI. The programme demonstrated a significant reduction in paediatric RTI after its implementation, in very specific ways. This study demonstrates that for a reasonable investment, scientifically driven injury-prevention programmes are feasible in resource-limited settings with high paediatric RTI rates. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

The Clinical and Economic Impact of Probiotics Consumption on Respiratory Tract Infections: Projections for Canada

PubMed Central

Gerlier, Laetitia; Roy, Denis; Reid, Gregor

2016-01-01

Introduction There is accumulating evidence supporting the use of probiotics, which are defined as “live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”, as a preventive measure against respiratory tract infections (RTI). Two recent meta-analyses showed probiotic consumption (daily intake of 107 to 1010 CFU in any form for up to 3 months) significantly reduced RTI duration, frequency, antibiotic use and work absenteeism. Objectives The aim of this study was to assess the impact of probiotic use in terms of number of RTI episodes and days averted, and the number of antibiotic prescriptions and missed workdays averted, in the general population of Canada. In addition, the corresponding economic impact from both a healthcare payer and a productivity perspective was estimated. Methods A microsimulation model was developed to reproduce the Canadian population (sample rate of 1/1000 = 35 540 individuals) employing age and gender. RTI incidence was taken from FluWatch consultation rates for influenza-like illness (2013–14) and StatCan all-cause consultations statistics. The model was calibrated on a 2.1% RTI annual incidence in the general population (5.2 million RTI days) and included known risk factors (smoking status, shared living conditions and vaccination status). RTI-related antibiotic prescriptions and work absenteeism were obtained from the literature. Results The results indicate that probiotic use saved 573 000–2.3 million RTI-days, according to the YHEC–Cochrane scenarios respectively. These reductions were associated with an avoidance of 52 000–84 000 antibiotic courses and 330 000–500 000 sick-leave days. A projection of corresponding costs reductions amounted to Can$1.3–8.9 million from the healthcare payer perspective and Can$61.2–99.7 million when adding productivity losses. Conclusion The analysis shows that the potential of probiotics to reduce RTI-related events may have a substantial clinical and economic impact in Canada. PMID:27832195

Linking Action Research to Response to Intervention (RtI): The Strategy Implementation Project

ERIC Educational Resources Information Center

Hoppey, David

2013-01-01

This paper showcases how one teacher preparation program embedded action research within the Response to Intervention (RtI) model. This integration helped preservice teachers gain a deeper knowledge of RtI key concepts and pedagogical decision making for meeting diverse students' needs. Examples from a course assignment are provided to demonstrate…

Teachers' Perceptions of Their RTI Skills as They Relate to Assessment, Instruction, and Intervention

ERIC Educational Resources Information Center

Christian, Karyn Spann

2013-01-01

The purpose of this study was to examine teachers' perceptions of their Response to Intervention (RTI) skills as they relate to assessment, instruction, and intervention. "The Perceptions of RTI Skills Survey" was distributed to 138 elementary general education teachers in ten elementary schools in six rural school districts, and ninety…

Response to Intervention: An Investigation of Training, Perceptions, and Fidelity of Implementation

ERIC Educational Resources Information Center

Latacha, Kathryn N.

2013-01-01

The authors investigated the extent to which the amount of training in Response to Intervention (RtI) impacts staff members' perceptions of RtI, how staff members' perceptions of RtI relate to their fidelity of implementation, and to what degree staff members' involvement in training influences their fidelity of implementation. A convenience…

A Middle School's Response-to-Intervention Journey: Building Systematic Processes of Facilitation, Collaboration, and Implementation

ERIC Educational Resources Information Center

Dulaney, Shannon K.

2013-01-01

This article discusses a qualitative case study examining one middle school's response to intervention (RtI) efforts. Study participants included the principal, assistant principal, and members of the school's leadership team. A description of the RtI consensus and infrastructure-building processes, consideration of the RtI facilitators, and a…

Response to Intervention: Ready or Not? Or, from Wait-to-Fail to Watch-Them-Fail

ERIC Educational Resources Information Center

Reynolds, Cecil R.; Shaywitz, Sally E.

2009-01-01

Response to Intervention (RTI) models of diagnosis and intervention are being implemented rapidly throughout the schools. The purposes of invoking an RTI model for disabilities in the schools clearly are laudable, yet close examination reveals an unappreciated paucity of empirical support for RTI and an overly optimistic view of its practical,…

A Cultural, Linguistic, and Ecological Framework for Response to Intervention with English Language Learners

ERIC Educational Resources Information Center

Brown, Julie Esparza; Doolittle, Jennifer

2008-01-01

Response to Intervention (RTI) has been heralded by many as the long-awaited alternative to using a discrepancy formula for special education eligibility decisions. RTI focuses on intervening early through a multi-tiered approach where each tier provides interventions of increasing intensity. RTI has the potential to affect change for English…

School Psychologists' Willingness to Implement RtI: The Role of Philosophical and Practical Readiness

ERIC Educational Resources Information Center

Fan, Chung-Hau; Denner, Peter R.; Bocanegra, Joel O.; Ding, Yi

2016-01-01

After the change in IDEIA, different models of response to intervention (RtI) have been practiced widely in American school systems. School psychologists are in an important position to facilitate RtI practice and provide professional development in order to help their school systems successfully undergo this transformation. However, there is a…

Exploring RTI Reading Intervention for Hispanic English Learning Kindergarten Students in Central Alabama: A Mixed Methods Study

ERIC Educational Resources Information Center

Hill, Kelly Leah

2013-01-01

This study addressed issues in implementing RTI Tier II reading intervention in kindergarten classrooms which contained Hispanic students learning English. In addition, the scope of reading progress of Hispanic students learning English was explored. The purpose of this research was to examine the frequency in providing RTI reading interventions…

A Descriptive Study of Response to Intervention (RTI) Implementation at the Elementary Level in West Virginia

ERIC Educational Resources Information Center

Lee, Sarah L.

2012-01-01

The purpose of this study was to describe levels of RTI implementation in West Virginia elementary schools. Little is known about the national efforts that states are collectively undertaking to scale up implementation of RTI (Hoover, Baca, Wexler-Love, & Saenz, 2008). West Virginia's elementary schools were required by state policy to…

Assessing African American Students for Specific Learning Disabilities: The Promises and Perils of Response to Intervention

ERIC Educational Resources Information Center

Proctor, Sherrie L.; Graves, Scott L., Jr.; Esch, Rachel C.

2012-01-01

Response to Intervention (RtI) consists of multi-tiered instructional delivery systems in which educators provide research-based interventions to students that increase in intensity depending on students' instructional response. RtI is currently being implemented in schools across the United States. RtI's shift away from standardized testing…

Competitions between Rayleigh-Taylor instability and Kelvin-Helmholtz instability with continuous density and velocity profiles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, W. H.; He, X. T.; CAPT, Peking University, Beijing 100871

2011-02-15

In this research, competitions between Rayleigh-Taylor instability (RTI) and Kelvin-Helmholtz instability (KHI) in two-dimensional incompressible fluids within a linear growth regime are investigated analytically. Normalized linear growth rate formulas for both the RTI, suitable for arbitrary density ratio with continuous density profile, and the KHI, suitable for arbitrary density ratio with continuous density and velocity profiles, are obtained. The linear growth rates of pure RTI ({gamma}{sub RT}), pure KHI ({gamma}{sub KH}), and combined RTI and KHI ({gamma}{sub total}) are investigated, respectively. In the pure RTI, it is found that the effect of the finite thickness of the density transition layermore » (L{sub {rho}}) reduces the linear growth of the RTI (stabilizes the RTI). In the pure KHI, it is found that conversely, the effect of the finite thickness of the density transition layer increases the linear growth of the KHI (destabilizes the KHI). It is found that the effect of the finite thickness of the density transition layer decreases the ''effective'' or ''local'' Atwood number (A) for both the RTI and the KHI. However, based on the properties of {gamma}{sub RT}{proportional_to}{radical}(A) and {gamma}{sub KH}{proportional_to}{radical}(1-A{sup 2}), the effect of the finite thickness of the density transition layer therefore has a completely opposite role on the RTI and the KHI noted above. In addition, it is found that the effect of the finite thickness of the velocity shear layer (L{sub u}) stabilizes the KHI, and for the most cases, the combined effects of the finite thickness of the density transition layer and the velocity shear layer (L{sub {rho}=}L{sub u}) also stabilize the KHI. Regarding the combined RTI and KHI, it is found that there is a competition between the RTI and the KHI because of the completely opposite effect of the finite thickness of the density transition layer on these two kinds of instability. It is found that the competitions between the RTI and the KHI depend, respectively, on the Froude number, the density ratio of the light fluid to the heavy one, and the finite thicknesses of the density transition layer and the velocity shear layer. Furthermore, for the fixed Froude number, the linear growth rate ratio of the RTI to the KHI decreases with both the density ratio and the finite thickness of the density transition layer, but increases with the finite thickness of the velocity shear layer and the combined finite thicknesses of the density transition layer and the velocity shear layer (L{sub {rho}=}L{sub u}). In summary, our analytical results show that the effect of the finite thickness of the density transition layer stabilizes the RTI and the overall combined effects of the finite thickness of the density transition layer and the velocity shear layer (L{sub {rho}=}L{sub u}) also stabilize the KHI. Thus, it should be included in applications where the transition layer effect plays an important role, such as the formation of large-scale structures (jets) in high energy density physics and astrophysics and turbulent mixing.« less

Hospital burden of road traffic injury: major concern in primary and secondary level hospitals in Bangladesh.

PubMed

Mashreky, S R; Rahman, A; Khan, T F; Faruque, M; Svanström, L; Rahman, F

2010-04-01

To assess the burden of road traffic injury (RTI) in primary and secondary level hospitals in Bangladesh, and its economic impact on affected families. Cross-sectional study. The study was carried out in February and March 2001. To estimate the burden of RTI patients and the length of stay in hospital, the discharge records of primary and secondary level hospitals were used as data sources. Records from 16 district hospitals and 45 Upazila health complexes (subdistrict level hospitals), selected at random, were included in this study. A direct interview method was adopted to estimate the patient costs of RTI; this involved interviewing patients or their attendants. In this study, patient costs included money spent by the patient for medicine, transport, food and lodging (including attendants). Approximately 33% of the beds in primary and secondary level hospitals in Bangladesh were occupied by injury-related patients, and more than 19% of the injury patients had been injured in a road traffic accident. People aged 18-45 years were the major victims of RTI, and constituted 70% of the total RTI-related admissions in primary and secondary level hospitals. More than two-thirds of RTI patients were male. The average duration of hospital stay was 5.7 days, and the average patient cost for each RTI patient was US$86 (5834 BDT). RTI is a major cause of hospital admission in Bangladesh, and represents an economic and social burden for the family and the nation. A national strategy and road safety programme need to be developed to reduce the hospital burden and minimize the economic and social impact. 2010 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

A Study of West Virginia Elementary Special Education Teachers' Roles, Responsibilities, and Practices within a Multi-Tiered Instructional System: Implications for Policy and Practice

ERIC Educational Resources Information Center

Palenchar, Linda M.

2012-01-01

The purpose of the study was to provide a data-based description of West Virginia special education teachers' roles, responsibilities, and practices relevant to their participation in selected components of the Response to Intervention (RTI) process. Special educators' practices related to assessment, tiered instruction, decision making, and…

A Study of the Effectiveness of Literacy Interventions on Middle and High School Students

ERIC Educational Resources Information Center

Luna, Jean; Gladson, Amy; Looney, Gina

2017-01-01

Response to Intervention and Instruction (RTI) is now the process for providing and monitoring reading interventions for students. In Tennessee, RTI is also used to identify students who may have a learning disability in the area of reading. For this reason, school districts are continuously evaluating the success of their RTI efforts in order to…

Middle School Teacher Satisfaction with Response to Intervention (RtI): An Assessment between Inception and Implementation

ERIC Educational Resources Information Center

Zahedi, Karynn Jensen

2010-01-01

Response to intervention (RtI) is a multi-tiered process of monitoring student responses to remediation that is designed to help struggling learners succeed within the purview of regular education. Under the RtI model, students are referred to special education only after a series of documented interventions have been attempted. This study…

RTI in a Middle School: Findings and Practical Implications of a Tier 2 Reading Comprehension Study

ERIC Educational Resources Information Center

Faggella-Luby, Michael; Wardwell, Michelle

2011-01-01

Response to intervention (RTI) has received considerable attention from both researchers and practitioners as a schoolwide model for service delivery. However, research is limited on RTI applications in middle and high schools. The purpose of this article is to describe the outcomes of an experimental examination of a secondary (Tier 2) literacy…

Elementary Principals' Perception of Response to Intervention (RtI) Implementation in North Carolina: An Exploratory Study

ERIC Educational Resources Information Center

Buckner, Jerry W.

2013-01-01

Conceptually, Response to Intervention (RtI) is a multi-tiered problem solving process rooted in special education yet designed as a framework for early and on-going instructional interventions for students across a continuum of academic need. In recent years, however, RtI has become an increasingly significant part of the discourse on school…

Looking beyond RtI Standard Treatment Approach: It's Not Too Late to Embrace the Problem-Solving Approach

ERIC Educational Resources Information Center

King, Diane; Coughlin, Patricia Kathleen

2016-01-01

There are two approaches for providing Tier 2 interventions within Response to Intervention (RtI): standard treatment protocol (STP) and the problem-solving approach (PSA). This article describes the multi-tiered RtI prevention model being implemented across the United States through an analysis of these two approaches in reading instruction. It…

Advanced gasifier and water gas shift technologies for low cost coal conversion to high hydrogen syngas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kramer, Andrew Kramer

The Gas Technology Institute (GTI) and team members RTI International (RTI), Coanda Research and Development, and Nexant, are developing and maturing a portfolio of technologies to meet the United States Department of Energy (DOE) goals for lowering the cost of producing high hydrogen syngas from coal for use in carbon capture power and coal-to-liquids/chemicals. This project matured an advanced pilot-scale gasifier, with scalable and commercially traceable components, to readiness for use in a first-of-a-kind commercially-relevant demonstration plant on the scale of 500-1,000 tons per day (TPD). This was accomplished through cold flow simulation of the gasifier quench zone transition regionmore » at Coanda and through an extensive hotfire gasifier test program on highly reactive coal and high ash/high ash fusion temperature coals at GTI. RTI matured an advanced water gas shift process and catalyst to readiness for testing at pilot plant scale through catalyst development and testing, and development of a preliminary design basis for a pilot scale reactor demonstrating the catalyst. A techno-economic analysis was performed by Nexant to assess the potential benefits of the gasifier and catalyst technologies in the context of power production and methanol production. This analysis showed an 18%reduction in cost of power and a 19%reduction in cost of methanol relative to DOE reference baseline cases.« less

Internal wave mode resonant triads in an arbitrarly stratified finite-depth ocean with background rotation

NASA Astrophysics Data System (ADS)

Varma, Dheeraj; Mathur, Manikandan

2017-11-01

Internal tides generated by barotropic tides on bottom topography or the spatially compact near-inertial mixed layer currents excited by surface winds can be conveniently represented in the linear regime as a superposition of vertical modes at a given frequency in an arbitrarily stratified ocean of finite depth. Considering modes (m , n) at a frequency ω in the primary wave field, we derive the weakly nonlinear solution, which contains a secondary wave at 2 ω that diverges when it forms a resonant triad with the primary waves. In nonuniform stratifications, resonant triads are shown to occur when the horizontal component of the classical RTI criterion k->1 +k->2 +k->3 = 0 is satisfied along with a non-orthogonality criterion. In nonuniform stratifications with a pycnocline, infinitely more pairs of primary wave modes (m , n) result in RTI when compared to a uniform stratification. Further, two nearby high modes at around the near-inertial frequency often form a resonant triad with a low mode at 2 ω , reminiscent of the features of PSI near the critical latitude. The theoretical framework is then adapted to investigate RTI in two different scenarios: low-mode internal tide scattering over topography, and internal wave beams incident on a pycnocline. The authors thank the Ministry of Earth Sciences, Government of India for financial support under the Monsoon Mission Grant MM/2014/IND-002.

Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital.

PubMed

Teh, Benjamin W; Worth, Leon J; Harrison, Simon J; Thursky, Karin A; Slavin, Monica A

2015-07-01

Infections are a leading cause of morbidity and mortality in patients with multiple myeloma. The epidemiology, risk factors and outcomes of viral respiratory tract infections (vRTI) are not well described in patients with multiple myeloma managed with novel agents, the current standard of care. Patients with myeloma from 2009 to 2012 who tested positive on respiratory virus multiplex polymerase chain reaction had clinical, radiological and microbiological records reviewed. The Fourth European Conference on Infections in Leukaemia (ECIL-4) definitions of RTI were applied. Univariate and multivariate regression analysis of risk factors was performed using vRTI as the evaluable outcome. Of 330 patients, 75 (22.7%) tested positive for a total of 100 vRTI episodes. All patients received thalidomide, lenalidomide or bortezomib in combination with myeloma therapies (median of three treatment regimens). vRTI occurred most commonly in patients with progressive disease, and receipt of more than three lines of myeloma therapy was associated with an increased risk of vRTI (p < 0.01). Amongst key respiratory pathogens, influenza was associated with the highest hospital admission rate (66.7%), ICU admission rate (41.6%) and mortality (33.3%) whilst RSV was associated with prolonged hospital stay. Patients with multiple myeloma and advanced disease managed with multiple lines of therapy are at risk for vRTI, and targeted interventions for prevention/treatment are required.

The Impact of School of Attendance, Classroom, Interventionist, Ethnicity, and Level of Educational Support on Oral Reading Fluency Measures

ERIC Educational Resources Information Center

Preston, Andrew James

2013-01-01

Response to intervention (RtI) is an approach to assist students with learning difficulties. There is limited research into the effectiveness of RtI within rural school districts. To address that gap, this quantitative, experimental study tested the theory of RtI, comparing the tier of intervention to oral reading fluency, controlling for…

Conceptualizing RTI in 21st-Century Secondary Science Classrooms: Video Games' Potential to Provide Tiered Support and Progress Monitoring for Students with Learning Disabilities

ERIC Educational Resources Information Center

Marino, Matthew T.; Beecher, Constance C.

2010-01-01

Secondary schools across the United States are adopting response to intervention (RTI) as a means to identify students with learning disabilities (LD) and provide tiered instructional interventions that benefit all students. The majority of current RTI research focuses on students with reading difficulties in elementary school classrooms.…

Exploring Students at Risk for Reading Comprehension Difficulties in South Korea: The RTI Approach Applying Latent Class Growth Analysis

ERIC Educational Resources Information Center

Kim, Dongil; Kim, Woori; Koh, Hyejung; Lee, Jaeho; Shin, Jaehyun; Kim, Heeju

2014-01-01

The purpose of this study was to identify students at risk of reading comprehension difficulties by using the responsiveness to intervention (RTI) approach. The participants were 177 students in Grades 1-3 in three elementary schools in South Korea. The students received Tier 1 instruction of RTI from March to May 2011, and their performance was…

Improving the timeliness and accuracy of injury severity data in road traffic accidents in an emerging economy setting.

PubMed

Lam, Carlos; Chen, Chang-I; Chuang, Chia-Chang; Wu, Chia-Chieh; Yu, Shih-Hsiang; Chang, Kai-Kuo; Chiu, Wen-Ta

2018-05-18

Road traffic injuries (RTIs) are among the leading causes of injury and fatality worldwide. RTI casualties are continually increasing in Taiwan; however, because of a lack of an advanced method for classifying RTI severity data, as well as the fragmentation of data sources, road traffic safety and health agencies encounter difficulties in analyzing RTIs and their burden on the healthcare system and national resources. These difficulties lead to blind spots during policy-making for RTI prevention and control. After compiling classifications applied in various countries, we summarized data sources for RTI severity in Taiwan, through which we identified data fragmentation. Accordingly, we proposed a practical classification for RTI severity, as well as a feasible model for collecting and integrating these data nationwide. This model can provide timely relevant data recorded by medical professionals and is valuable to healthcare providers. The proposed model's pros and cons are also compared to those of other current models.

The case for improving road safety in Pacific Islands: a population-based study from Fiji (TRIP 6).

PubMed

Herman, Josephine; Ameratunga, Shanthi; Wainiqolo, Iris; Kafoa, Berlin; McCaig, Eddie; Jackson, Rod

2012-10-01

To estimate the incidence and demographic characteristics associated with road traffic injuries (RTIs) resulting in deaths or hospital admission for 12 hours or more in Viti Levu, Fiji. Analysis of the prospective population-based Fiji Injury Surveillance in Hospitals database (October 2005 - September 2006). Of the 374 RTI cases identified (17% of all injuries), 72% were males and one third were aged 15-29 years. RTI fatalities (10.3 per 100,000 per year) were higher among Indians compared to Fijians. Two-thirds of deaths (largely ascribed to head, chest and abdominal trauma) occurred before hospital admission. While the RTI fatality rate was comparable to the global average for high-income countries, the level of motorisation in Fiji is considerably lower. To avert rising RTI rates with increasing motorisation, Fiji requires a robust road safety strategy alongside effective trauma-care services and a reliable population-based RTI surveillance system. © 2012 The Authors. ANZJPH © 2012 Public Health Association of Australia.

Association between diurnal temperature range and respiratory tract infections.

PubMed

Ge, Wen Zhen; Xu, Feng; Zhao, Zhuo Hui; Zhao, Jin Zhuo; Kan, Hai Dong

2013-03-01

This study aimed to assess the association between emergency-room visits for respiratory tract infection (RTI) with diurnal temperature range (DTR), a weather parameter closely associated with urbanization and global climate change. We conducted a semiparametric time-series analysis to estimate the percentage increase in emergency-room visits for RTI associated with changes in DTR after adjustment for daily weather conditions (temperature and relative humidity) and outdoor air pollution. DTR was significantly associated with daily emergency-room visits for RTI. An increase of 1 °C in the current-day (L0) and in the 2-day moving average (L01) DTR corresponded to a 0.94% [95% confidence interval (CI), 0.34%-1.55%] and 2.08% (95% CI, 1.24%-2.93%) increase in emergency-room visits for RTI, respectively. DTR was associated with increased risk of RTI. More studies are needed to understand the impact of DTR on respiratory health. Copyright © 2013 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

Effect of bromine-dopant on radiation-driven Rayleigh-Taylor instability in plastic foil

NASA Astrophysics Data System (ADS)

Xu, Binbin; Ma, Yanyun; Yang, Xiaohu; Tang, Wenhui; Ge, Zheyi; Zhao, Yuan; Ke, Yanzhao; Kawata, Shiego

2017-10-01

Effects of bromine (Br) dopant on the growth of radiation-driven ablative Rayleigh-Taylor instability (RTI) in plastic foils are studied by radiation hydrodynamics simulations and theoretical analysis. It is found that the Br-dopant in plastic foil reduces the seed of ablative RTI. The main reasons of the reduction are attributed to the smaller oscillation amplitude of ablative Richtmyer-Meshkov instability (RMI) induced by the smaller post-shock sound speed, and the smaller oscillation frequency of ablative RMI induced by the smaller ablation velocity and blow-off plasma velocity. The Br-dopant also decreases the linear growth rate of ablative RTI due to the smaller acceleration. Treating the perturbation growth as a function of foil’s displacement, the perturbation growth would increase in Br-doped foil at the phase of ablative RTI, which is attributed to the decrease of the ablation velocity and the density gradient scale length. The results are helpful for further understanding the influence of high-Z dopant on the radiation-driven ablative RTI.

Characterizing Multiple Wireless Sensor Networks for Large-Scale Radio Tomography

DTIC Science & Technology

2015-03-01

with other transceivers over a wireless frequency. A base station transceiver collects the information and processes the information into something...or most other obstructions in between the two links [4]. A base station transceiver is connected to a processing computer to collect the RSS of each... transceivers at four different heights to create a Three-Dimensional (3-D) RTI network. Using shadowing- based RTI, this research demonstrated that RTI

Differential patterns, trends and hotspots of road traffic injuries on different road networks in Vellore district, southern India.

PubMed

Mohan, Venkata Raghava; Sarkar, Rajiv; Abraham, Vinod Joseph; Balraj, Vinohar; Naumova, Elena N

2015-03-01

To describe spatial and temporal profiles of Road Traffic Injuries (RTIs) on different road networks in Vellore district of southern India. Using the information in the police maintained First Information Reports (FIRs), daily time series of RTI counts were created and temporal characteristics were analysed with respect to the vehicle, road types and time of the day for the period January 2005 to May 2007. Daily incidence and trend of RTIs were estimated using a Poisson regression analysis. Of the reported 3262 RTIs, 52% had occurred on the National Highway (NH). The overall RTI rate on the NH was 8.8/100 000 vehicles per day with significantly higher pedestrian involvement. The mean numbers of RTIs were significantly higher on weekends. Thirteen percentage of all RTIs were associated with fatalities. Hotspots are major town junctions, and RTI rates differ over different stretches of the NH. In India, FIRs form a valuable source of RTI information. Information on different vehicle profile, RTI patterns, and their spatial and temporal trends can be used by administrators to devise effective strategies for RTI prevention by concentrating on the high-risk areas, thereby optimising the use of available personnel and resources. © 2014 John Wiley & Sons Ltd.

Effects of a semi-infinite stratification on the Rayleigh-Taylor instability in an interface with surface tension

NASA Astrophysics Data System (ADS)

de Andrea González, Ángel; González-Gutiérrez, Leo M.

2017-09-01

The Rayleigh-Taylor instability (RTI) in an infinite slab where a constant density lower fluid is initially separated from an upper stratified fluid is discussed in linear regime. The upper fluid is of increasing exponential density and surface tension is considered between both of them. It was found useful to study stability by using the initial value problem approach (IVP), so that we ensure the inclusion of certain continuum modes, otherwise neglected. This methodology includes the branch cut in the complex plane, consequently, in addition to discrete modes (surface RTI modes), a set of continuum modes (internal RTI modes) also appears. As a result, the usual information given by the normal mode method is now complete. Furthermore, a new role is found for surface tension: to transform surface RTI modes (discrete spectrum) into internal RTI modes belonging to a continuous spectrum at a critical wavenumber. As a consequence, the cut-off wavenumber disappears: i.e. the growth rate of the RTI surface mode does not decay to zero at the cut-off wavenumber, as previous researchers used to believe. Finally, we found that, due to the continuum, the asymptotic behavior of the perturbation with respect to time is slower than the exponential when only the continuous spectrum exists.

Road Traffic Injury Trends in the City of Valledupar, Colombia. A Time Series Study from 2008 to 2012

PubMed Central

Rodríguez, Jorge Martín; Peñaloza, Rolando Enrique; Moreno Montoya, José

2015-01-01

Objective To analyze the behavior temporal of road-traffic injuries (RTI) in Valledupar, Colombia from January 2008 to December 2012. Methodology An observational study was conducted based on records from the Colombian National Legal Medicine and Forensic Sciences Institute regional office in Valledupar. Different variables were analyzed, such as the injured person’s sex, age, education level, and type of road user; the timeframe, place and circumstances of crashes and the vehicles associated with the occurrence. Furthermore, a time series analysis was conducted using an auto-regressive integrated moving average. Results There were 105 events per month on an average, 64.9% of RTI involved men; 82.3% of the persons injured were from 18 to 59 years of age; the average age was 35.4 years of age; the road users most involved in RTI were motorcyclists (69%), followed by pedestrians (12%). 70% had up to upper-secondary education. Sunday was the day with the most RTI occurrences; 93% of the RTI occurred in the urban area. The time series showed a seasonal pattern and a significant trend effect. The modeling process verified the existence of both memory and extrinsic variables related. Conclusions An RTI occurrence pattern was identified, which showed an upward trend during the period analyzed. Motorcyclists were the main road users involved in RTI, which suggests the need to design and implement specific measures for that type of road user, from regulations for graduated licensing for young drivers to monitoring road user behavior for the promotion of road safety. PMID:26657887

Road Traffic Injury Trends in the City of Valledupar, Colombia. A Time Series Study from 2008 to 2012.

PubMed

Rodríguez, Jorge Martín; Peñaloza, Rolando Enrique; Moreno Montoya, José

2015-01-01

To analyze the behavior temporal of road-traffic injuries (RTI) in Valledupar, Colombia from January 2008 to December 2012. An observational study was conducted based on records from the Colombian National Legal Medicine and Forensic Sciences Institute regional office in Valledupar. Different variables were analyzed, such as the injured person's sex, age, education level, and type of road user; the timeframe, place and circumstances of crashes and the vehicles associated with the occurrence. Furthermore, a time series analysis was conducted using an auto-regressive integrated moving average. There were 105 events per month on an average, 64.9% of RTI involved men; 82.3% of the persons injured were from 18 to 59 years of age; the average age was 35.4 years of age; the road users most involved in RTI were motorcyclists (69%), followed by pedestrians (12%). 70% had up to upper-secondary education. Sunday was the day with the most RTI occurrences; 93% of the RTI occurred in the urban area. The time series showed a seasonal pattern and a significant trend effect. The modeling process verified the existence of both memory and extrinsic variables related. An RTI occurrence pattern was identified, which showed an upward trend during the period analyzed. Motorcyclists were the main road users involved in RTI, which suggests the need to design and implement specific measures for that type of road user, from regulations for graduated licensing for young drivers to monitoring road user behavior for the promotion of road safety.

Road traffic injuries in one local health unit in the Lazio region: results of a surveillance system integrating police and health data

PubMed Central

Chini, Francesco; Farchi, Sara; Ciaramella, Ivana; Antoniozzi, Tranquillo; Rossi, Paolo Giorgi; Camilloni, Laura; Valenti, Massimo; Borgia, Piero

2009-01-01

Objective Different sources are available for the surveillance of Road Traffic injuries (RTI), but studied individually they present several limits. In this paper we present the results of a surveillance integrating healthcare data with the data gathered by the municipal police in the southeastern area of Rome (630,000 inhabitants) during the year 2003. Methods The Municipal police RTI reports, which list the exact location, circumstances and some risk factor of the crash, were searched in the emergency visit, hospitalization and mortality databases, to integrate them with the information on health consequences. A multivariate analysis was conducted to evaluate risk factors (crash circumstances, age ad gender of the casualty) associated with hospital admission following a RTI. Mapping of RTI locations was created. The locations with higher risk of accidents with severe health consequences and at higher risk for pedestrians were identified. Results According to police records 4571 RTI occurred in 2003, 75% of which led to emergency department admissions. Sixteen percent of these emergency visits ended in hospitalization, and 44 deaths were reported within 30 days of the event, most of which occurred in young men. The people with the highest risk of hospitalization after an RTI were the cyclists, pedestrians and followed by people on two-wheeled vehicles. The type of crash with the highest risk of hospitalization was head-on collision. Geographical analyses showed four clusters with higher severity of RTI. Specific attention was paid to pedestrian injuries. Analyzing the locations of RTIs involving pedestrians permitted us to rank the most dangerous streets. The roads at high risk for pedestrians identified problems in the bus stop constructions and in the placement of the zebra pedestrian crossings. Conclusion This study proves the feasibility of an integrated surveillance system of RTI by using routinely collected local data. The high-risk locations identified with the geographic analyses method in this study highlighted infrastructural problems, suggesting immediate preventive interventions. PMID:19386112

Responding to the Need for Research in RTI: A Map of the Current Implementation and Assessment Practices from the Perspective of District and Building Administrators

ERIC Educational Resources Information Center

Hudson, Tina Marlene

2013-01-01

Response to Intervention (RTI) has been one of the most significant developments in the history of educational reform, requiring a renewed focus on evidence-based instruction and data-driven decisions. However, the current use of RTI as a means of identifying students with SLD is highly variable across states, bringing to focus several issues that…

[Study on the secular trend of road traffic injuries and its influencing factors in China].

PubMed

Chi, Gui-bo; Wang, Sheng-Yong

2007-02-01

To analyze and summarize the secular trend and influencing factors of road traffic injuries(RTI) in China, so as to provide evidence for the management of traffic safety. Indexes as fatalities per 10,000 vehicles, fatalities per 100,000 population, fatalities per 10,000 kilometers, motorization(number of vehicles per 1000 population) and mortal coefficient were used. Clustering analysis and ranking correlation were used to analyze the relative factors. The number of casualties of RTI had doubled every decade before the year of 2000. One hundred thousand people were killed in RTI every year since 2000. Facts as: Gross National Product(GNP) of China exceeded 1000 USD in 2002, number of motor vehicles reached 1.3 million in 2005, had both influenced the rates of road traffic fatality, mileage fatality and mortal coefficient which causing them to drop since 2002. In China, RTI happened in the underdeveloped districts in the western part of the country including Tibet, Ningxia, Xinjiang, Qinghai, and in some coastal areas as Zhejiang and Guangdong provinces. Men seemed to be more at risk than women in RTI, and accounted for three-quarters of the victims. Majority of fatalities happened in 21-50 year olds and the fatalities among those over 65 year olds had risen every year. The vulnerable populations in road-user category were pedestrians, passengers, motorcyclists and bicyclists. Under most situations, drivers were responsible for RTI and over half of them were professionals. Bad behaviors were the major causes of RTI, including exceeding the speed limit, handle misfeasance, breaking traffic rules and regulation, having taken alcohol or driving with fatigue etc. Exceeding the speed limit was the most risky factor which causing 75% of the RTI and the traffic deaths increased between 2002 to 2004. A positive correlation was discovered between population fatality rate and the factors as the number of vehicles, volume of road haulage, volume of passengers and the degree of highway etc. with correlation coefficients as r1 = 0.986, r2 = 0.986, r3 = 0.987, r4 = 0.985, P = 0.001, respectively. Since 1951, the population fatality rate of RTI had been going up continuously until it began to fall in 2003.

Coupling between interface and velocity perturbations in the weakly nonlinear Rayleigh-Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L. F.; Ye, W. H.; He, X. T.

2012-11-15

Weakly nonlinear (WN) Rayleigh-Taylor instability (RTI) initiated by single-mode cosinusoidal interface and velocity perturbations is investigated analytically up to the third order. Expressions of the temporal evolutions of the amplitudes of the first three harmonics are derived. It is shown that there are coupling between interface and velocity perturbations, which plays a prominent role in the WN growth. When the 'equivalent amplitude' of the initial velocity perturbation, which is normalized by its linear growth rate, is compared to the amplitude of the initial interface perturbation, the coupling between them dominates the WN growth of the RTI. Furthermore, the RTI wouldmore » be mitigated by initiating a velocity perturbation with a relative phase shift against the interface perturbation. More specifically, when the phase shift between the interface perturbation and the velocity perturbation is {pi} and their equivalent amplitudes are equal, the RTI could be completely quenched. If the equivalent amplitude of the initial velocity perturbation is equal to the initial interface perturbation, the difference between the WN growth of the RTI initiated by only an interface perturbation and by only a velocity perturbation is found to be asymptotically negligible. The dependence of the WN growth on the Atwood numbers and the initial perturbation amplitudes is discussed. In particular, we investigate the dependence of the saturation amplitude (time) of the fundamental mode on the Atwood numbers and the initial perturbation amplitudes. It is found that the Atwood numbers and the initial perturbation amplitudes play a crucial role in the WN growth of the RTI. Thus, it should be included in applications where the seeds of the RTI have velocity perturbations, such as inertial confinement fusion implosions and supernova explosions.« less

Indenopyride derivative RTI-4587-073(l): a candidate for male contraception in stallions.

PubMed

Pozor, Malgorzata A; Macpherson, Margo L; McDonnell, Sue M; Nollin, Maggie; Roser, Janet F; Love, Charles; Runyon, Scott; Thomas, Brian F; Troedsson, Mats H

2013-12-01

The objective of this study was to determine whether an indenopyridine derivative RTI-4587-073(l) was a good candidate for male contraception in horses. We hypothesized that a single administration of RTI-4587-073(l) causes significant suppression of testicular function in stallions without affecting sexual behavior. Three Miniature horse stallions received a single dose of 12.5 mg/kg RTI-4587-073(l) orally (group "treated"), whereas three other Miniature horse stallions received placebo only (group "control"). Semen was collected and evaluated from all stallions twice a week for three baseline weeks and 13 post-treatment weeks. Sexual behavior was video-recorded and analyzed. Testicular dimensions were measured using ultrasonography, and blood samples were drawn for endocrine evaluation once before treatment and once a week during the post-treatment period. Single administration of RTI-4587-073(l) caused severe oligoasthenozoospermia (low sperm number and low motility), shedding large numbers of immature germ cells in semen, and increased FSH concentrations in treated stallions. These effects were fully reversible within ∼71 days. However, libido and copulatory behavior remained unchanged throughout the entire experiment. We concluded that RTI-4587-073(l) was a promising candidate for male contraceptive in domestic stallions. Further research should be performed to test this compound for fertility control in wildlife and humans. Copyright © 2013 Elsevier Inc. All rights reserved.

Particle Size Characterization of Water-Elutriated Libby Amphibole 2000 and RTI International Amosite

USGS Publications Warehouse

Lowers, Heather; Bern, Amy M.

2009-01-01

This report presents data on particle characterization analyzed by scanning electron microscopy on Libby amphibole collected by the U.S. Geological Survey in 2000 (LA2000) and amosite material collected by RTI International (RTI amosite). The particle characterization data were generated to support a portion of the Libby Action Plan. Prior to analysis, the raw LA2000 and RTI amosite materials were subjected to a preparation step. Each sample was water-elutriated by U.S. Environmental Protection Agency (USEPA) Office of Research and Development, Research Triangle Park using the methods generally described in another published report and then delivered to the U.S. Geological Survey, Denver Microbeam Laboratory for analysis. Data presented here represent analyses performed by the U.S. Geological Survey, Denver Microbeam Laboratory and USEPA National Enforcement Investigations Center. This report consists of two Excel spreadsheet files developed by USEPA, Region 8 Superfund Technical Assistance Unit and describe the particle size characterization of the LA2000 and RTI amosite, respectively. Multiple tabs and data entry cells exist in each spreadsheet and are defined herein.

Long Term Effects of First Grade Multi-Tier Intervention

PubMed Central

Otaiba, Stephanie Al; Kim, Young-Suk; Wanzek, Jeanne; Petscher, Yaacov; Wagner, Richard K.

2014-01-01

The purpose of this study was to compare the long term effects of two first grade RTI models (Dynamic and Typical RTI) on the reading performance of students in second and third grade. Participants included 419 first grade students (352 in second grade and 278 in third grade after attrition). Students were classified based on first grade screeners as at-risk or not at-risk and then based on their response to intervention (no risk [NR], relative easy to remediate [ER] and requiring sustained remediation [SR]). Students in the Dynamic RTI condition had higher reading comprehension scores at the end of third grade. At the end of second grade, ER and SR students had lower reading scores than NR students. At the end of third grade, there were no differences in reading skills between ER and NR students, but SR students had lower scores than NR students. ER students in the Dynamic RTI condition had higher reading scores at the end of second grade than those in the Typical RTI condition. Limitations and directions for future research are discussed. PMID:25346781

Responses of lung parenchyma and airways to tachykinin peptides in piglets.

PubMed

Dreshaj, I A; Martin, R J; Miller, M J; Haxhiu, M A

1994-07-01

The tachykinin peptides substance P (SP) and neurokinin A (NKA) have been shown to induce tracheal smooth muscle contraction in piglets, and the enzyme neutral endopeptidase has been shown to modulate this effect. In these studies, we compared the SP and NKA responsiveness of piglet airways and lung parenchymal tissues in anesthetized paralyzed open-chest piglets 2-3 wk old, partitioning total lung resistance (RL) into airway resistance (Raw) and tissue resistance (Rti). During tidal breathing, pressure was measured at the trachea and in two alveolar regions by means of alveolar capsules. Intravenous administration of SP caused concentration-dependent increases in Rti and Raw and a decrease in dynamic lung compliance. Under baseline conditions, Rti contributed 74.6 +/- 1.9% (SE) of RL, and at any level of constriction, Rti accounted for > 50% of RL. The responses of Rti and Raw to NKA were negligible and were always significantly weaker than those to SP. These results indicate that both central airways and tissue contractile elements respond vigorously to SP, but not to NKA, in maturing piglets.

Control Software

NASA Technical Reports Server (NTRS)

1997-01-01

Real-Time Innovations, Inc. (RTI) collaborated with Ames Research Center, the Jet Propulsion Laboratory and Stanford University to leverage NASA research to produce ControlShell software. RTI is the first "graduate" of Ames Research Center's Technology Commercialization Center. The ControlShell system was used extensively on a cooperative project to enhance the capabilities of a Russian-built Marsokhod rover being evaluated for eventual flight to Mars. RTI's ControlShell is complex, real-time command and control software, capable of processing information and controlling mechanical devices. One ControlShell tool is StethoScope. As a real-time data collection and display tool, StethoScope allows a user to see how a program is running without changing its execution. RTI has successfully applied its software savvy in other arenas, such as telecommunications, networking, video editing, semiconductor manufacturing, automobile systems, and medical imaging.

Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions

NASA Astrophysics Data System (ADS)

Wang, LiFeng; Ye, WenHua; He, XianTu; Wu, JunFeng; Fan, ZhengFeng; Xue, Chuang; Guo, HongYu; Miao, WenYong; Yuan, YongTeng; Dong, JiaQin; Jia, Guo; Zhang, Jing; Li, YingJun; Liu, Jie; Wang, Min; Ding, YongKun; Zhang, WeiYan

2017-05-01

Inertial fusion energy (IFE) has been considered a promising, nearly inexhaustible source of sustainable carbon-free power for the world's energy future. It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion (ICF) hot-spot ignition scheme. In this mini-review, we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade. In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF, we first decompose the problem into different stages according to the implosion physics processes. The decomposed essential physics pro- cesses that are associated with ICF implosions, such as Rayleigh-Taylor instability (RTI), Richtmyer-Meshkov instability (RMI), Kelvin-Helmholtz instability (KHI), convergent geometry effects, as well as perturbation feed-through are reviewed. Analyti- cal models in planar, cylindrical, and spherical geometries have been established to study different physical aspects, including density-gradient, interface-coupling, geometry, and convergent effects. The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations. The KHI considering the ablation effect has been discussed in detail for the first time. A series of single-mode ablative RTI experiments has been performed on the Shenguang-II laser facility. The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths, and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions, which has directly supported the research of ICF ignition target design. The ICF hot-spot ignition implosion design that uses several controlling features, based on our current understanding of hydrodynamic instabilities, to address shell implosion stability, has been briefly described, several of which are novel.

22st Annual National Test and Evaluation Conference

DTIC Science & Technology

2006-03-09

B1 B2 y ii) Factor B affects the standard deviation C2 C1 y iii) Factor C affects the average and the standard deviation D1 = D2 y iv) Factor D has...22303 UNITED STATES (P) (703)862-0908 (F) (703)970-5700 poole_grady@emc.com Mr. Josh Pressnell RTI 8306 Rugby Rd. Manassas, VA 20111...Ricciardi RTI 8306 Rugby Rd. Manassas, VA 20111-1912 UNITED STATES (P) (703)365-9662 (F) (703)365-9818 michael.ricciardi@rti-world.com Mr

Business Models for Cost Sharing and Capability Sustainment

DTIC Science & Technology

2012-04-30

studies in the research include the following:  Programs o F-35 Lightning II (U.S./UK) o AV-8B/Harrier (U.S./UK) o Super Hornet (U.S.) o...made to learn internally how the Typhoon aircraft could benefit from an RTI approach. Externally, the use of a small group , such as the RTI team...long time frame. In order to identify the key factors in the Harrier RTI success, a SWOT analysis was carried out. The results are shown in Table 1

Aircraft data summaries for the SURE intensives. Final report. [Sampling done July 1978 near Duncan Falls, Ohio and Scranton, Pennsylvania

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keifer, W.S.; Blumenthal, D.L.; Tommerdahl, J.B.

1981-09-01

As part of the EPRI sulfate regional experiment (SURE), Meteorology Research, Inc., (MRI) and Research Triangle Institute (RTI) conducted six air quality sampling programs in the eastern United States using instrumented aircraft. This volume includes the air quality and meteorological data obtained during the July 1978 Intensive when MRI sampled near the Duncan Falls, Ohio, SURE Station and RTI sampled near the Scranton, Pennsylvania, SURE Station. During the last part of the July 1978 sampling period, both MRI and RTI aircraft participated in a large regional-scale sampling program with Brookhaven National Laboratory (BNL) and Pacific Northwest Laboratory (PNL). Only themore » data obtained by the MRI and RTI aircraft during this regional-scale sapling program are included in this volume.« less

Probing the deep nonlinear stage of the ablative Rayleigh-Taylor instability in indirect drive experiments on the National Ignition Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casner, A., E-mail: alexis.casner@cea.fr; Masse, L.; Liberatore, S.

2015-05-15

Academic tests in physical regimes not encountered in Inertial Confinement Fusion will help to build a better understanding of hydrodynamic instabilities and constitute the scientifically grounded validation complementary to fully integrated experiments. Under the National Ignition Facility (NIF) Discovery Science program, recent indirect drive experiments have been carried out to study the ablative Rayleigh-Taylor Instability (RTI) in transition from weakly nonlinear to highly nonlinear regime [A. Casner et al., Phys. Plasmas 19, 082708 (2012)]. In these experiments, a modulated package is accelerated by a 175 eV radiative temperature plateau created by a room temperature gas-filled platform irradiated by 60 NIF lasermore » beams. The unique capabilities of the NIF are harnessed to accelerate this planar sample over much larger distances (≃1.4 mm) and longer time periods (≃12 ns) than previously achieved. This extended acceleration could eventually allow entering into a turbulent-like regime not precluded by the theory for the RTI at the ablation front. Simultaneous measurements of the foil trajectory and the subsequent RTI growth are performed and compared with radiative hydrodynamics simulations. We present RTI growth measurements for two-dimensional single-mode and broadband multimode modulations. The dependence of RTI growth on initial conditions and ablative stabilization is emphasized, and we demonstrate for the first time in indirect-drive a bubble-competition, bubble-merger regime for the RTI at ablation front.« less

Weakly nonlinear incompressible Rayleigh-Taylor instability growth at cylindrically convergent interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L. F.; He, X. T.; HEDPS, Center for Applied Physics and Technology, Peking University, Beijing 100871

2013-04-15

A weakly nonlinear (WN) model has been developed for the incompressible Rayleigh-Taylor instability (RTI) in cylindrical geometry. The transition from linear to nonlinear growth is analytically investigated via a third-order solutions for the cylindrical RTI initiated by a single-mode velocity perturbation. The third-order solutions can depict the early stage of the interface asymmetry due to the bubble-spike formation, as well as the saturation of the linear (exponential) growth of the fundamental mode. The WN results in planar RTI [Wang et al., Phys. Plasmas 19, 112706 (2012)] are recovered in the limit of high-mode number perturbations. The difference between the WNmore » growth of the RTI in cylindrical geometry and in planar geometry is discussed. It is found that the interface of the inward (outward) development spike/bubble is extruded (stretched) by the additional inertial force in cylindrical geometry compared with that in planar geometry. For interfaces with small density ratios, the inward growth bubble can grow fast than the outward growth spike in cylindrical RTI. Moreover, a reduced formula is proposed to describe the WN growth of the RTI in cylindrical geometry with an acceptable precision, especially for small-amplitude perturbations. Using the reduced formula, the nonlinear saturation amplitude of the fundamental mode and the phases of the Fourier harmonics are studied. Thus, it should be included in applications where converging geometry effects play an important role, such as the supernova explosions and inertial confinement fusion implosions.« less

Reverse Transcriptase Inhibitors as Potential Colorectal Microbicides▿ †

PubMed Central

Herrera, Carolina; Cranage, Martin; McGowan, Ian; Anton, Peter; Shattock, Robin J.

2009-01-01

We investigated whether reverse transcriptase (RT) inhibitors (RTI) can be combined to inhibit human immunodeficiency virus type 1 (HIV-1) infection of colorectal tissue ex vivo as part of a strategy to develop an effective rectal microbicide. The nucleotide RTI (NRTI) PMPA (tenofovir) and two nonnucleoside RTI (NNRTI), UC-781 and TMC120 (dapivirine), were evaluated. Each compound inhibited the replication of the HIV isolates tested in TZM-bl cells, peripheral blood mononuclear cells, and colorectal explants. Dual combinations of the three compounds, either NRTI-NNRTI or NNRTI-NNRTI combinations, were more active than any of the individual compounds in both cellular and tissue models. Combinations were key to inhibiting infection by NRTI- and NNRTI-resistant isolates in all models tested. Moreover, we found that the replication capacities of HIV-1 isolates in colorectal explants were affected by single point mutations in RT that confer resistance to RTI. These data demonstrate that colorectal explants can be used to screen compounds for potential efficacy as part of a combination microbicide and to determine the mucosal fitness of RTI-resistant isolates. These findings may have important implications for the rational design of effective rectal microbicides. PMID:19258271

Reverse transcriptase inhibitors as potential colorectal microbicides.

PubMed

Herrera, Carolina; Cranage, Martin; McGowan, Ian; Anton, Peter; Shattock, Robin J

2009-05-01

We investigated whether reverse transcriptase (RT) inhibitors (RTI) can be combined to inhibit human immunodeficiency virus type 1 (HIV-1) infection of colorectal tissue ex vivo as part of a strategy to develop an effective rectal microbicide. The nucleotide RTI (NRTI) PMPA (tenofovir) and two nonnucleoside RTI (NNRTI), UC-781 and TMC120 (dapivirine), were evaluated. Each compound inhibited the replication of the HIV isolates tested in TZM-bl cells, peripheral blood mononuclear cells, and colorectal explants. Dual combinations of the three compounds, either NRTI-NNRTI or NNRTI-NNRTI combinations, were more active than any of the individual compounds in both cellular and tissue models. Combinations were key to inhibiting infection by NRTI- and NNRTI-resistant isolates in all models tested. Moreover, we found that the replication capacities of HIV-1 isolates in colorectal explants were affected by single point mutations in RT that confer resistance to RTI. These data demonstrate that colorectal explants can be used to screen compounds for potential efficacy as part of a combination microbicide and to determine the mucosal fitness of RTI-resistant isolates. These findings may have important implications for the rational design of effective rectal microbicides.

Initial results of Pakistan's first road traffic injury surveillance project.

PubMed

Shamim, Shahzad; Razzak, Junaid A; Jooma, Rashid; Khan, Uzma

2011-09-01

Our aim is to report the findings of the initial three years of road traffic injuries (RTI) surveillance at Karachi and to compare it with previously published RTI-related data from Pakistan and other low-and middle-income countries. Data were collected through the RTI surveillance programme at Karachi (RTIRP) from the five biggest emergency departments of the city, which receive almost all the major emergencies of the city for the period September 2006 till September 2009. A total of 99,272 victims were enlisted by the RTIRP during the study period. Annual incidence of RTI is calculated to be 184.3 per 100,000 populations and mortality is 5.7 per 100,000 populations. Eighty nine per cent of victims are male and 73% are between 15 and 44 years of age. Commonest road user to be affected is riders of two wheelers (45%). Only 7% of affected motorcyclists were found to be wearing helmets at the time of the accident. Trends of injuries remained uniform over the years. Most frequent injuries were external wounds, followed by orthopaedic injuries. On the basis of our surveillance system, we have presented the largest RTI-related data from a metropolitan city of Pakistan to date.

Maraviroc, as a Switch Option, in HIV-1–infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study

PubMed Central

Pett, Sarah Lilian; Amin, Janaki; Horban, Andrejz; Andrade-Villanueva, Jaime; Losso, Marcelo; Porteiro, Norma; Sierra Madero, Juan; Belloso, Waldo; Tu, Elise; Silk, David; Kelleher, Anthony; Harrigan, Richard; Clark, Andrew; Sugiura, Wataru; Wolff, Marcelo; Gill, John; Gatell, Jose; Fisher, Martin; Clarke, Amanda; Ruxrungtham, Kiat; Prazuck, Thierry; Kaiser, Rolf; Woolley, Ian; Arnaiz, Juan Alberto; Cooper, David; Rockstroh, Jürgen K.; Mallon, Patrick; Emery, Sean; Kelleher, Anthony; Merlin, Kate; Yeung, Julie; Fsadni, Bertha; Marks, Kat; Suzuki, Kazuo; Rismanto, Nick; Salomon, Horacio; Rubio, Andrea E.; Chibo, Doris; Birch, Chris; Harrigan, Richard; Swenson, Luke; Chan, Dennison; Berg, Thomas; Obermeier, Martin; Kaiser, Rolf; Schuelter, Eugen; Sierra Aragon, Saleta; Luebke, Nadine; Coughlan, Suzie; Dean, Jonathan; Sugiura, Wataru; Iwatani, Yasumasa; Reyes Teran, Gustavo; Avila, Santiago; Ruxrungtham, Kiat; Sirivichayakul, Sunee; Naphassanant, May; Ubolyam, Sasiwimol; Kaye, Steve; Land, Sally; Walker, Sarah; Haubrich, Richard; DeJesus, Edwin; Emery, Sean; Pett, Sarah L.; Tu, Elise; Silk, David; Berthon-Jones, Nisha; Amin, Janaki; Espinosa, Natalie; Courtney-Vega, Kymme; Absar, Noorul; Haskelberg, Hila; Robson, Rose; Donaldson, Anna; Losso, Marcelo; Belloso, Waldo; Guelman, Daniel; Gambardella, Luciana; Valdovinos, Mariana; Gatell, Jose; Arnaiz, Juan; Beleta, Helena; Ramos, Nuria; Targa, Marta; Rockstroh, Jurgen; Späth, Brigitta; Boesecke, Christoph; Engelhardt, Angelika; Fisher, Martin; Perry, Nicky; Clarke, Amanda; Gill, John; Beckthold, Brenda; Clark, Andrew; Drummond, Fraser; Lefevre, Eric; Corr, Sharon; Grant, Carol; Lupo, Sergio; Peroni, Luciana; Italiano, Hospital; Sanchez, Marisa; De Paz Sierra, Mariana; Mejia, Ramos; Losso, Marcelo; Viloria, Guillermo; Parlante, Angel; Bissio, Emiliano; Luchetti, Pablo; Warley, Eduardo; Vieni, Ines; Porteiro, Norma; Vilas, Cecilia; Zarate, Abel; Mayer, Gabriela; Elliot, Julian; Hagenauer, Michelle; Kelley, Mark; Rowling, Diane; Gibson, Abby; Latch, Ngaire; Tabrett, Chantal; Warzywoda, Elizabeth; Cooper, David; Pett, Sarah; MacRae, Karen; Sinclair, Brett; Sinn, Kate; Bloch, Mark; Franic, Teo; Vincent, Trina; Stewart, Natasha; Jayewardene, Avindra; Dwyer, Dominic; Kok, Jennifer; Assam, Delene; Taylor, Janette; King, Patricia; Orth, David; Youds, David; Sowden, David; Johnston, Colleen; Murray, Suzanne; Hehir, Jennifer; Wadham, Samantha; Donohue, William; Thompson, Jill; Garsia, Roger; Turnham, Geoffrey; Madden, Tracey; Woolley, Ian; Gillies, Ainsley; Bryant, Mellissa; Gill, John; Beckthold, Brenda; Walmsley, Sharon; Chan, Warmond; LeBlanc, Roger; Lanteigne, Francois; Mouawad, Rima; Rahal, Ines; Guber, Sergio; Ozturk, Sefika; Smith, Graham; Halpenny, Roberta; Reko, Tatjana; Robinette Hills, Jennifer; Wolff, Marcelo; Prazuck, Thierry; Laurent Hocqueloux, Francois; Wolfgang, Johann; Stephan, Christoph; Ebeling, Franziska; Rockstroh, Juergen; Boesecke, Christoph; Spath, Brigitta; Engelhardt, Angelika; Ole Jensen, Bjorn-Erik; Feind, Cecilie; Meyer-Olson, Dirk; Stoll, Matthias; Hoeper, Kirsten; Beider, Renata; Faetkenheur, Gerd; Thomas Baumgarten, Ellen; Baumgarten, Axel; Ingiliz, Patrick; Wienbreyer, Andreas; Behrendt, Daniela; Nienkarken, Tanja; Stein, Jessen; Jessen, Heiko; Zedlack, Carmen; Mallon, Paddy; Simelane, Sibongile; Assmann, Jennifer; Ghavami-Kia, Bijan; Sugiura, Wataru; Imahashi, Mayumi; Tanabe, Kazue; Yokomaku, Yoshiyuki; Imamura, Junji; Andrade-Villanueva, Jaime; Montes de Oca, Melva; Gonzalez, Lucero; Ponce, David; Mendoza, Andrea; Sierra-Madero, Juan; Sanchez Hernandez, Jesus Eduardo; Jaime Ruiz Ballesteros, Eduardo; del Moral Ponce, Sergio; Mosqueda, Luis; Lopez, Monica; Horban, Andrzej; Ignatowska, Anna; Bakowska, Elzbieta; Pulik, Piotr; Sanz-Moreno, Jose; Paredes, Roger; Puig, Jordi; Domingo, Pere; Gutierrez, Mar; Gatell, Jose; González-Cordón, Ana; Callau, Pili; Lopez Aldeguer, Jose; Cuellar Tovar, Sandra; Leal Noval, Manuel; Rivas, Inmaculada; Delgado-Fernandez, Marcial; Ramon Arribas, Jose; Miguel Castro, Juan; Ruxrungtham, Kiat; Avihingsanon, Anchalee; Maek-a-nantawat, Wirach; Intasan, Jintana; Charoenporn, Walairat; Cuprasitrut, Thidarat; Jaisomkom, Pachuen; Pruksakaew, Kanchana; Winston, Alan; Mullaney, Scott; Fisher, Martin; Clarke, Amanda; Barbour, Lisa; Perry, Nicky; Richardson, Celia; Fox, Julie; Murray, Tammy; Leen, Clifford; Morris, Shelia; Satyajit, Das; Sandhu, Rumun; Tucker, James

2016-01-01

Abstract Background. Alternative combination antiretroviral therapies in virologically suppressed human immunodeficiency virus (HIV)–infected patients experiencing side effects and/or at ongoing risk of important comorbidities from current therapy are needed. Maraviroc (MVC), a chemokine receptor 5 antagonist, is a potential alternative component of therapy in those with R5-tropic virus. Methods. The Maraviroc Switch Study is a randomized, multicenter, 96-week, open-label switch study in HIV type 1–infected adults with R5-tropic virus, virologically suppressed on a ritonavir-boosted protease inhibitor (PI/r) plus double nucleoside/nucleotide reverse transcriptase inhibitor (2 N(t)RTI) backbone. Participants were randomized 1:2:2 to current combination antiretroviral therapy (control), or replacing the protease inhibitor (MVC + 2 N(t)RTI arm) or the nucleoside reverse transcriptase inhibitor backbone (MVC + PI/r arm) with twice-daily MVC. The primary endpoint was the difference (switch minus control) in proportion with plasma viral load (VL) <200 copies/mL at 48 weeks. The switch arms were judged noninferior if the lower limit of the 95% confidence interval (CI) for the difference in the primary endpoint was < −12% in the intention-to-treat (ITT) population. Results. The ITT population comprised 395 participants (control, n = 82; MVC + 2 N(t)RTI, n = 156; MVC + PI/r, n = 157). Baseline characteristics were well matched. At week 48, noninferior rates of virological suppression were observed in those switching away from a PI/r (93.6% [95% CI, −9.0% to 2.2%] and 91.7% [95% CI, −9.6% to 3.8%] with VL <200 and <50 copies/mL, respectively) compared to the control arm (97.6% and 95.1% with VL <200 and <50 copies/mL, respectively). In contrast, MVC + PI/r did not meet noninferiority bounds and was significantly inferior (84.1% [95% CI, −19.8% to −5.8%] and 77.7% [95% CI, −24.9% to −8.4%] with VL <200 and <50 copies/mL, respectively) to the control arm in the ITT analysis. Conclusions. These data support MVC as a switch option for ritonavir-boosted PIs when partnered with a 2-N(t)RTI backbone, but not as part of N(t)RTI-sparing regimens comprising MVC with PI/r. Clinical Trials Registration. NCT01384682. PMID:27048747

The influence of HLA supertype on thymidine analogue associated with low peripheral fat in HIV.

PubMed

Cordery, Damien V; Martin, Allison; Amin, Janaki; Kelleher, Anthony D; Emery, Sean; Cooper, David A

2012-11-28

To examine the relationship between human leukocyte antigen (HLA) genotype and body composition changes induced by thymidine analogue nucleoside reverse transcriptase inhibitor (NtRTI) use in HIV-positive individuals. Data collected during the Simplification with Tenofovir-Emtricitabine (TDF-FTC) or Abacavir-Lamivudine (ABC-3TC) (STEAL) study were analysed to examine the potential association of HLA genotypes with changes in body composition in treatment-experienced HIV-positive individuals. Demographic, HIV-related, body composition and HLA genotyping data from the STEAL study were used in this analysis. The mean percentage peripheral fat at study baseline was compared in participants with and without prior NtRTI use. Analyses were also carried out for each HLA supertype strata, for five HLA genes, within the thymidine-exposed group. These comparisons were made using Mann-Whitney rank-sum tests. Participants with prior NtRTI use had a significantly lower baseline mean peripheral fat percentage compared to those without NtRTI use (31.9 vs. 34.7%; P = 0.0045). However, participants carrying one or more of the three particular HLA supertype alleles, A01, B08 and DQ2, showed no significant difference in mean peripheral fat percentage at baseline by NtRTI use. Among participants with prior NtRTI exposure, there were significant differences in mean peripheral fat by HLA A01, B08 and DQ2 allele expression compared to those without expression of these alleles (A01: 34.91% vs. no A01: 30.3%; P = 0.0087; B08: 36.2% vs. no B08: 31.1%; P = 0.0317; DQ2: 35.16% vs. no DQ2: 30.06%; P = 0.0081). This analysis suggests that HIV-infected individuals carrying HLA A01, B08 or DQ2 supertype alleles may be resistant to NtRTI-induced peripheral fat loss.

Demonstration of a real-time interferometer as a bunch-length monitor in a high-current electron beam accelerator.

PubMed

Thangaraj, J; Andonian, G; Thurman-Keup, R; Ruan, J; Johnson, A S; Lumpkin, A; Santucci, J; Maxwell, T; Murokh, A; Ruelas, M; Ovodenko, A

2012-04-01

A real-time interferometer (RTI) has been developed to monitor the bunch length of an electron beam in an accelerator. The RTI employs spatial autocorrelation, reflective optics, and a fast response pyro-detector array to obtain a real-time autocorrelation trace of the coherent radiation from an electron beam thus providing the possibility of online bunch-length diagnostics. A complete RTI system has been commissioned at the A0 photoinjector facility to measure sub-mm bunches at 13 MeV. Bunch length variation (FWHM) between 0.8 ps (~0.24 mm) and 1.5 ps (~0.45 mm) has been measured and compared with a Martin-Puplett interferometer and a streak camera. The comparisons show that RTI is a viable, complementary bunch length diagnostic for sub-mm electron bunches. © 2012 American Institute of Physics

Demonstration of a real-time interferometer as a bunch-lenght monitor in a high-current electron beam accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thangaraj, J.; Thurman-Keup, R.; Ruan, J.

2012-03-01

A real-time interferometer (RTI) has been developed to monitor the bunch length of an electron beam in an accelerator. The RTI employs spatial autocorrelation, reflective optics, and a fast response pyro-detector array to obtain a real-time autocorrelation trace of the coherent radiation from an electron beam thus providing the possibility of online bunch-length diagnostics. A complete RTI system has been commissioned at the A0 photoinjector facility to measure sub-mm bunches at 13 MeV. Bunch length variation (FWHM) between 0.8 ps (-0.24 mm) and 1.5 ps (-0.45 mm) has been measured and compared with a Martin-Puplett interferometer and a streak camera.more » The comparisons show that RTI is a viable, complementary bunch length diagnostic for sub-mm electron bunches.« less

Demonstration of a real-time interferometer as a bunch-length monitor in a high-current electron beam accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thangaraj, J.; Thurman-Keup, R.; Ruan, J.

2012-04-15

A real-time interferometer (RTI) has been developed to monitor the bunch length of an electron beam in an accelerator. The RTI employs spatial autocorrelation, reflective optics, and a fast response pyro-detector array to obtain a real-time autocorrelation trace of the coherent radiation from an electron beam thus providing the possibility of online bunch-length diagnostics. A complete RTI system has been commissioned at the A0 photoinjector facility to measure sub-mm bunches at 13 MeV. Bunch length variation (FWHM) between 0.8 ps ({approx}0.24 mm) and 1.5 ps ({approx}0.45 mm) has been measured and compared with a Martin-Puplett interferometer and a streak camera.more » The comparisons show that RTI is a viable, complementary bunch length diagnostic for sub-mm electron bunches.« less

Raman scattering in the RTiO3 family of Mott-Hubbard insulators

NASA Astrophysics Data System (ADS)

Reedyk, M.; Crandles, D. A.; Cardona, M.; Garrett, J. D.; Greedan, J. E.

1997-01-01

Raman-scattering measurements have been carried out for crystals of the RTiO3 (R=La,Ce,Pr,Nd,Sm,Gd) system whose members are Mott-Hubbard insulators. RTiO3 has an orthorhombically distorted perovskite unit cell. The distortion increases systematically from LaTiO3 to GdTiO3 and is accompanied by changes in electronic structure (decreasing W/U ratio). As a consequence of the changing electronic properties, the Raman spectrum shows an interesting evolution of both the phonon features and the electronic continuum. Most notable are (1) a redistribution in the spectral shape of the electronic background, (2) a systematic change in line shape, and a dramatic increase in the center frequency of one of the phonon modes from 287 cm-1 in LaTiO3 to 385 cm-1 in GdTiO3, and (3) the observation of resonance effects in the most insulating members of the series. The appearance of a free-carrier component in the electronic-scattering background, which seems to be related to systematic self-energy effects of the phonon near 300 cm-1, is unexpected. It is likely the result of increased doping due to a greater facility for rare-earth vacancies to form in large R3+ ionic radius members of the series. A systematic increase in the continuum scattering rate is also observed and indicates that the free carriers are not scattering off rare-earth vacancies but rather that the scattering mechanism originates from changes in electronic structure.

Burden of motorcycle-related injury in Malaysia.

PubMed

Rahman, Nik Hisamuddin Na; Baharuddin, Kamarul A; Mohamad, Syarifah Mastura S

2015-01-01

Road traffic injury (RTI) contributes to major morbidity and mortality in both developed and developing countries. Most of the injuries are caused by road-related injuries that specifically relate to motorcycle crash. We attempted to conduct a short survey to determine the magnitude of burden related to motorcycle-related RTIs in Malaysia. We hypothesize that motorcycle-related RTI in Malaysia contributes significantly to the health burden in the country. The cross-sectional survey involves data searching related to RTI in Malaysia from the relevant agencies such as the Ministry of Health Malaysia, Royal Police Force, and Malaysia Institute of Road Safety Research (MIROS) through their official websites and PubMed search. The three agencies are well established and recognized by the Malaysian government in dealing with data collection for the injury nationwide. The primary aim is to determine the prevalence of motorcycle-related RTI, and secondary outcomes are the overall mortality and the contributing factors. Of the cause of trauma, 80 % is due to RTI, and the most vulnerable road users such as pedestrians and motorcyclists are affected the most. Of all RTI, 70 % is contributed by the motorcycle crash, and there are a significant number of deaths for both rider and pillion rider of the motorcycle than for other types of vehicles. Human error is the main reason to be blamed, specifically the attitude of the riders on the road. Trauma is one of the common reasons for death and hospitalization in Malaysia. Motorcycle-related RTI in Malaysia contributes significantly to the health burden in Malaysia. The Malaysian government and non-government agencies have worked together seriously in implementing a preventive measure to reduce the incidence and aftermath of motorcycle-related RTI. However, data is still lacking, and every effort is made to increase the amount of research in the field. Strengths of the article are as follows:Latest alarming data on motorcycle-related injuries in the developing country.The data is collected from multi-agencies recognized by ministries in the country.Very limited publication specifically on motorcycle-related injuries is available. Limitations of the article are as follows:The data is only from one country.The statistical data is gathered from a variety of sources, i.e., relevant agencies and authorities and website of the involved ministries.

Combining virtual reality and multimedia techniques for effective maintenance training

NASA Astrophysics Data System (ADS)

McLin, David M.; Chung, James C.

1996-02-01

This paper describes a virtual reality (VR) system developed for use as part of an integrated, low-cost, stand-alone, multimedia trainer. The trainer is used to train National Guard personnel in maintenance and trouble-shooting tasks for the M1A1 Abrams tank, the M2A2 Bradley fighting vehicle and the TOW II missile system. The VR system features a modular, extensible, object-oriented design which consists of a training monitor component, a VR run time component, a model loader component, and a set of domain-specific object behaviors which mimic the behavior of objects encountered in the actual vehicles. The VR system is built from a combination of off-the-shelf commercial software and custom software developed at RTI.

ENVIRONMENTAL TECHNOLOGY VERIFICATION FOR INDOOR AIR PRODUCTS

EPA Science Inventory

The paper discusses environmental technology verification (ETV) for indoor air products. RTI is developing the framework for a verification testing program for indoor air products, as part of EPA's ETV program. RTI is establishing test protocols for products that fit into three...

Comprehensive numerical methodology for direct numerical simulations of compressible Rayleigh-Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reckinger, Scott James; Livescu, Daniel; Vasilyev, Oleg V.

A comprehensive numerical methodology has been developed that handles the challenges introduced by considering the compressive nature of Rayleigh-Taylor instability (RTI) systems, which include sharp interfacial density gradients on strongly stratified background states, acoustic wave generation and removal at computational boundaries, and stratification-dependent vorticity production. The computational framework is used to simulate two-dimensional single-mode RTI to extreme late-times for a wide range of flow compressibility and variable density effects. The results show that flow compressibility acts to reduce the growth of RTI for low Atwood numbers, as predicted from linear stability analysis.

Nonlinear Evolution of Rayleigh-Taylor Instability in a Radiation-supported Atmosphere

NASA Astrophysics Data System (ADS)

Jiang, Yan-Fei; Davis, Shane W.; Stone, James M.

2013-02-01

The nonlinear regime of Rayleigh-Taylor instability (RTI) in a radiation supported atmosphere, consisting of two uniform fluids with different densities, is studied numerically. We perform simulations using our recently developed numerical algorithm for multi-dimensional radiation hydrodynamics based on a variable Eddington tensor (VET) as implemented in Athena, focusing on the regime where scattering opacity greatly exceeds absorption opacity. We find that the radiation field can reduce the growth and mixing rate of RTI, but this reduction is only significant when radiation pressure significantly exceeds gas pressure. Small-scale structures are also suppressed in this case. In the nonlinear regime, dense fingers sink faster than rarefied bubbles can rise, leading to asymmetric structures about the interface. By comparing the calculations that use a VET versus the Eddington approximation, we demonstrate that anisotropy in the radiation field can affect the nonlinear development of RTI significantly. We also examine the disruption of a shell of cold gas being accelerated by strong radiation pressure, motivated by models of radiation driven outflows in ultraluminous infrared galaxies. We find that when the growth timescale of RTI is smaller than acceleration timescale, the amount of gas that would be pushed away by the radiation field is reduced due to RTI.

Strong Leadership for RTI Success

ERIC Educational Resources Information Center

Mellard, Daryl F.; Prewett, Sara; Deshler, Donald D.

2012-01-01

During the past decade, thousands of schools have adopted response to intervention (RTI) frameworks as the means of improving educational outcomes for all students, including those with disabilities. Planning, implementing, and sustaining those frameworks requires organizational changes that affect staff members and underlying school structures…

Association between intensity modulated radiotherapy and survival in patients with stage III non-small cell lung cancer treated with chemoradiotherapy.

PubMed

Koshy, Matthew; Malik, Renuka; Spiotto, Michael; Mahmood, Usama; Rusthoven, Chad G; Sher, David J

2017-06-01

To determine the effect of radiotherapy (RT) technique on treatment compliance and overall survival (OS) in patients with stage III non-small lung cancer (NSCLC) treated with definitive chemoradiotherapy (CRT). This study included patients with stage III NSCLC in the National Cancer Database treated between 2003 and 2011 with definitive CRT to 60-63 Gray (Gy). Radiation treatment interruption (RTI) was defined as a break of ≥4 days. Treatment technique was dichotomized as intensity modulated (IMRT) or non-IMRT techniques. Out of the cohort of 7492, 35% had a RTI and 10% received IMRT. With a median follow-up of surviving patients of 32 months, the median survival for those with non-IMRT vs. IMRT was 18.2 months vs. 20 months (p<0.0001). Median survival for those with and without an RTI≥4 days was 16.1 months vs. 19.8 months (p<0.0001). Use of IMRT predicted for a decreased likelihood of RTI (odds ratio, 0.84, p=0.04). On multivariable analysis for OS, IMRT had a HR of 0.89 (95% CI: 0.80-0.98, p=0.01) and RTI had a HR of 1.2 (95% confidence interval (CI): 1.14-1.27, p=0.001). IMRT was associated with small but significant survival advantage for patients with stage III NSCLC treated with CRT. A RTI led to inferior survival, and both IMRT and RTI were independently associated with OS. Additional research should investigate whether improved tolerability, reduced normal tissue exposure, or superior coverage drives the association between IMRT and improved survival. Copyright © 2017 Elsevier B.V. All rights reserved.

Distribution of Trauma Care Facilities in Oman in Relation to High-Incidence Road Traffic Injury Sites: Pilot study.

PubMed

Al-Kindi, Sara M; Naiem, Ahmed A; Taqi, Kadhim M; Al-Gheiti, Najla M; Al-Toobi, Ikhtiyar S; Al-Busaidi, Nasra Q; Al-Harthy, Ahmed Z; Taqi, Alaa M; Ba-Alawi, Sharif A; Al-Qadhi, Hani A

2017-11-01

Road traffic injuries (RTIs) are considered a major public health problem worldwide. In Oman, high numbers of RTIs and RTI-related deaths are frequently registered. This study aimed to evaluate the distribution of trauma care facilities in Oman with regards to their proximity to RTI-prevalent areas. This descriptive pilot study analysed RTI data recorded in the national Royal Oman Police registry from January to December 2014. The distribution of trauma care facilities was analysed by calculating distances between areas of peak RTI incidence and the closest trauma centre using Google Earth and Google Maps software (Google Inc., Googleplex, Mountain View, California, USA). A total of 32 trauma care facilities were identified. Four facilities (12.5%) were categorised as class V trauma centres. Of the facilities in Muscat, 42.9% were ranked as class IV or V. There were no class IV or V facilities in Musandam, Al-Wusta or Al-Buraimi. General surgery, orthopaedic surgery and neurosurgery services were available in 68.8%, 59.3% and 12.5% of the centres, respectively. Emergency services were available in 75.0% of the facilities. Intensive care units were available in 11 facilities, with four located in Muscat. The mean distance between a RTI hotspot and the nearest trauma care facility was 34.7 km; however, the mean distance to the nearest class IV or V facility was 83.3 km. The distribution and quality of trauma care facilities in Oman needs modification. It is recommended that certain centres upgrade their levels of trauma care in order to reduce RTI-associated morbidity and mortality in Oman.

Evaluating the Impacts of Real-Time Information on Subway Ridership in New York City

DOT National Transportation Integrated Search

2018-05-21

It is now common for transit operators to provide real-time information (RTI) to passengers about the location or predicted arrival times of transit vehicles. The Metropolitan Transportation Authority (MTA) in New York City has recently made RTI avai...

RTI in Middle School Classrooms: Proven Tools and Strategies

ERIC Educational Resources Information Center

Esteves, Kelli J.; Whitten, Elizabeth

2014-01-01

"RTI in Middle School Classrooms" provides practical, research-based instructional techniques and interventions--geared especially to middle school teachers and administrators--that target and address specific needs of individual students. Response to intervention allows educators to assess and meet the needs of struggling students…

Alternative Strategies in Assessing Special Education Needs

ERIC Educational Resources Information Center

Dykeman, Bruce F.

2006-01-01

The conventional use of standardized testing within a discrepancy analysis model is reviewed. The Response-to-Intervention (RTI) process is explained, along with descriptions of assessment procedures within RTI: functional assessment, authentic assessment, curriculum-based measurement, and play-based assessment. Psychometric issues relevant to RTI…

State of Practice for Emerging Waste Conversion Technologies

EPA Science Inventory

RTI International (RTI) was contracted by the U.S. Environmental Protection Agency (EPA), Office of Research and Development to conduct research to prepare a “State of Practice” report to support State and local decision-makers on the subject of emerging waste conversion technolo...

Stable radiation pressure acceleration of ions by suppressing transverse Rayleigh-Taylor instability with multiple Gaussian pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, M. L.; Liu, B.; Hu, R. H.

In the case of a thin plasma slab accelerated by the radiation pressure of an ultra-intense laser pulse, the development of Rayleigh-Taylor instability (RTI) will destroy the acceleration structure and terminate the acceleration process much sooner than theoretical limit. In this paper, a new scheme using multiple Gaussian pulses for ion acceleration in a radiation pressure acceleration regime is investigated with particle-in-cell simulation. We found that with multiple Gaussian pulses, the instability could be efficiently suppressed and the divergence of the ion bunch is greatly reduced, resulting in a longer acceleration time and much more collimated ion bunch with highermore » energy than using a single Gaussian pulse. An analytical model is developed to describe the suppression of RTI at the laser-plasma interface. The model shows that the suppression of RTI is due to the introduction of the long wavelength mode RTI by the multiple Gaussian pulses.« less

Alcohol and Road Traffic Injuries in Latin America and the Caribbean: A Case-Crossover Study.

PubMed

Borges, Guilherme; Monteiro, Maristela; Cherpitel, Cheryl J; Orozco, Ricardo; Ye, Yu; Poznyak, Vladimir; Peden, Margie; Pechansky, Flavio; Cremonte, Mariana; Reid, Sandra D; Mendez, Jesus

2017-10-01

This study reports dose-response estimates for the odds ratio (OR) and population attributable risk of acute alcohol use and road traffic injury (RTI). Data were analyzed on 1,119 RTI patients arriving at 16 emergency departments (EDs) in Argentina, Brazil, Costa Rica, Dominican Republic, Guatemala, Guyana, Mexico, Nicaragua, Panama, and Trinidad and Tobago. Case-crossover analysis, pair-matching the number of standard drinks consumed within the 6 hours prior to the RTI with 2 control periods (prior d/wk), was performed using fractional polynomial analysis for dose-response. About 1 in 6 RTI patients in EDs were positive for self-reported alcohol 6 hours prior to the injury (country range 8.6 to 24.1%). The likelihood of an RTI with any drinking prior (compared to not drinking) was 5 times higher (country range OR 2.50 to 15.00) and the more a person drinks the higher the risk. Every drink (12.8 g alcohol) increased the risk of an RTI by 13%, even 1 to 2 drinks were associated with a sizable increase in risk of an RTI and a dose-response was found. Differences in ORs for drivers (OR = 3.51; 95% CI = 2.25 to 5.45), passengers (OR = 8.12; 95% CI = 4.22 to 15.61), and pedestrians (OR = 6.30; 95% CI = 3.14 to 12.64) and attributable fractions were noted. Acute use of alcohol was attributable to 14% of all RTIs, varying from 7% for females to 19% for being injured as a passenger. The finding that the presence of alcohol increases risk among drivers and nondrivers alike may further help to urge interventions targeting passengers and pedestrians. Routine screening and brief interventions in all health services could also have a beneficial impact in decreasing rates of RTIs. Higher priority should be given to alcohol as a risk factor for RTIs, particularly in Latin America and the Caribbean. Copyright © 2017 by the Research Society on Alcoholism.

Transition from orbital liquid to Jahn-Teller insulator in orthorhombic perovskites RTiO3.

PubMed

Cheng, J-G; Sui, Y; Zhou, J-S; Goodenough, J B; Su, W H

2008-08-22

Following the same strategy used for RVO3, thermal conductivity measurements have been made on a series of single-crystal perovskites RTiO3 (R=La,Nd,...,Yb). Results reveal explicitly a transition from an orbital liquid to an orbitally ordered phase at a magnetic transition temperature, which is common for both the antiferromagnetic and ferromagnetic phases in the phase diagram of RTiO3. This spin/orbital transition is consistent with the mode softening at T_{N} in antiferromagnetic LaTiO3 and is supported by an anomalous critical behavior at T_{c} in ferromagnetic YTiO3.

Response to Intervention: Research and Practice

ERIC Educational Resources Information Center

Hall, Carol; Mahoney, Jamie

2013-01-01

Response to Intervention (RTI) is a service model designed to meet the learning needs of students prior to diagnosis and placement in special education settings. Results of a quantitative quasi-experimental research study to investigate the relationship between the RTI plan and self-reported implementation practices among general education…

Monitoring Students with ADHD within the RTI Framework

ERIC Educational Resources Information Center

Haraway, Dana L.

2012-01-01

Students with Attention Deficit Hyperactivity Disorders (ADHD) can present unique behavioral and academic challenges within the school environment. The Response to Intervention (RTI) and Positive Behavior Interventions and Supports (PBIS) movements have sought to formalize intervention systems to address the needs of all children. An integral…

ENVIRONMENTAL TECHNOLOGY PROTOCOL VERIFICATION REPORT, EMISSIONS OF VOCS AND ALDEHYDES FROM COMMERCIAL FURNITURE (WITH APPENDICES)

EPA Science Inventory

As part of a U.S. Environmental Protection Agency Environmental Technology Verification program, the Research Triangle Institute (RTI) developed a test protocol for measuring volatile organic compounds and aldehydes in a large chamber. RTI convened stakeholders for the commercial...

Reshaping RTI: Building a Better Triangle

ERIC Educational Resources Information Center

Ramaswami, Rama

2010-01-01

Response to intervention (RTI), the controversial three-tiered, triangular instructional model is getting stretched in new directions by educators who favor holistic, proactive support strategies over formal remediation. A senior scientist at the FPG Child Development Institute at the University of North Carolina at Chapel Hill, Virginia Buysse…

RTI Goes Mainstream

ERIC Educational Resources Information Center

Pascopella, Angela

2010-01-01

In more districts than ever, Response-to-Intervention programs are gaining ground, nipping learning problems in the bud and keeping more students out of unnecessary special education classes, which is the goal. RTI, a multi-tier intervention used to diagnose and address potential learning or behavioral problem early, is also increasing in…

Rayleigh-Taylor instability-fascinating gateway to the study of fluid dynamics

NASA Astrophysics Data System (ADS)

Benjamin, Robert F.

1999-09-01

A series of low-cost simple, "kitchen-physics" experiments demonstrates Rayleigh-Taylor Instability (RTI), the growth of ripples at an interface between fluids when the higher-density fluid is on top. We also describe the importance of RTI in ocean dynamics and commercial products.

RTI & Differentiated Reading in the K-8 Classroom

ERIC Educational Resources Information Center

Bender, William N.; Waller, Laura

2011-01-01

In "RTI & Differentiated Reading in the K-8 Classroom," the authors argue that whole-group reading instruction in general education classes is no longer an appropriate learning environment. They outline three innovations that educators can integrate to dramatically improve reading instruction from kindergarten through the upper elementary…

Brazilian Road Traffic Fatalities: A Spatial and Environmental Analysis

PubMed Central

de Andrade, Luciano; Vissoci, João Ricardo Nickenig; Rodrigues, Clarissa Garcia; Finato, Karen; Carvalho, Elias; Pietrobon, Ricardo; de Souza, Eniuce Menezes; Nihei, Oscar Kenji; Lynch, Catherine; de Barros Carvalho, Maria Dalva

2014-01-01

Background Road traffic injuries (RTI) are a major public health epidemic killing thousands of people daily. Low and middle-income countries, such as Brazil, have the highest annual rates of road traffic fatalities. In order to improve road safety, this study mapped road traffic fatalities on a Brazilian highway to determine the main environmental factors affecting road traffic fatalities. Methods and Findings Four techniques were utilized to identify and analyze RTI hotspots. We used spatial analysis by points by applying kernel density estimator, and wavelet analysis to identify the main hot regions. Additionally, built environment analysis, and principal component analysis were conducted to verify patterns contributing to crash occurrence in the hotspots. Between 2007 and 2009, 379 crashes were notified, with 466 fatalities on BR277. Higher incidence of crashes occurred on sections of highway with double lanes (ratio 2∶1). The hotspot analysis demonstrated that both the eastern and western regions had higher incidences of crashes when compared to the central region. Through the built environment analysis, we have identified five different patterns, demonstrating that specific environmental characteristics are associated with different types of fatal crashes. Patterns 2 and 4 are constituted mainly by predominantly urban characteristics and have frequent fatal pedestrian crashes. Patterns 1, 3 and 5 display mainly rural characteristics and have higher prevalence of vehicular collisions. In the built environment analysis, the variables length of road in urban area, limited lighting, double lanes roadways, and less auxiliary lanes were associated with a higher incidence of fatal crashes. Conclusions By combining different techniques of analyses, we have identified numerous hotspots and environmental characteristics, which governmental or regulatory agencies could make use to plan strategies to reduce RTI and support life-saving policies. PMID:24498051

Maraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.

PubMed

Pett, Sarah Lilian; Amin, Janaki; Horban, Andrejz; Andrade-Villanueva, Jaime; Losso, Marcelo; Porteiro, Norma; Sierra Madero, Juan; Belloso, Waldo; Tu, Elise; Silk, David; Kelleher, Anthony; Harrigan, Richard; Clark, Andrew; Sugiura, Wataru; Wolff, Marcelo; Gill, John; Gatell, Jose; Fisher, Martin; Clarke, Amanda; Ruxrungtham, Kiat; Prazuck, Thierry; Kaiser, Rolf; Woolley, Ian; Arnaiz, Juan Alberto; Cooper, David; Rockstroh, Jürgen K; Mallon, Patrick; Emery, Sean

2016-07-01

Alternative combination antiretroviral therapies in virologically suppressed human immunodeficiency virus (HIV)-infected patients experiencing side effects and/or at ongoing risk of important comorbidities from current therapy are needed. Maraviroc (MVC), a chemokine receptor 5 antagonist, is a potential alternative component of therapy in those with R5-tropic virus. The Maraviroc Switch Study is a randomized, multicenter, 96-week, open-label switch study in HIV type 1-infected adults with R5-tropic virus, virologically suppressed on a ritonavir-boosted protease inhibitor (PI/r) plus double nucleoside/nucleotide reverse transcriptase inhibitor (2 N(t)RTI) backbone. Participants were randomized 1:2:2 to current combination antiretroviral therapy (control), or replacing the protease inhibitor (MVC + 2 N(t)RTI arm) or the nucleoside reverse transcriptase inhibitor backbone (MVC + PI/r arm) with twice-daily MVC. The primary endpoint was the difference (switch minus control) in proportion with plasma viral load (VL) <200 copies/mL at 48 weeks. The switch arms were judged noninferior if the lower limit of the 95% confidence interval (CI) for the difference in the primary endpoint was < -12% in the intention-to-treat (ITT) population. The ITT population comprised 395 participants (control, n = 82; MVC + 2 N(t)RTI, n = 156; MVC + PI/r, n = 157). Baseline characteristics were well matched. At week 48, noninferior rates of virological suppression were observed in those switching away from a PI/r (93.6% [95% CI, -9.0% to 2.2%] and 91.7% [95% CI, -9.6% to 3.8%] with VL <200 and <50 copies/mL, respectively) compared to the control arm (97.6% and 95.1% with VL <200 and <50 copies/mL, respectively). In contrast, MVC + PI/r did not meet noninferiority bounds and was significantly inferior (84.1% [95% CI, -19.8% to -5.8%] and 77.7% [95% CI, -24.9% to -8.4%] with VL <200 and <50 copies/mL, respectively) to the control arm in the ITT analysis. These data support MVC as a switch option for ritonavir-boosted PIs when partnered with a 2-N(t)RTI backbone, but not as part of N(t)RTI-sparing regimens comprising MVC with PI/r. NCT01384682. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Availability and Quality of Prehospital Care on Pakistani Interurban Roads

PubMed Central

Bhatti, Junaid A.; Waseem, Hunniya; Razzak, Junaid A.; Shiekh, Naeem-ul-lah; Khoso, Ajmal Khan; Salmi, L.-Rachid

2013-01-01

Interurban road crashes often result in severe Road Traffic Injuries (RTIs). Prehospital emergency care on interurban roads was rarely evaluated in the low- and middle-income countries. The study highlighted the availability and quality of prehospital care facilities on interurban roads in Pakistan, a low-income country. The study setting was a 592-km-long National highway in the province of Sindh, Pakistan. Using the questionnaires adapted from the World Health Organization prehospital care guidelines [Sasser et al., 2005], managers and ambulance staff at the stations along highways were interviewed regarding the process of care, supplies in ambulances, and their experience of trauma care. Ambulance stations were either managed by the police or the Edhi Foundation (EF), a philanthropic organization. All highway stations were managed by the EF; the median distance between highway stations was 38 km (Interquartile Range [IQR]=27–46). We visited 14 stations, ten on the highway section, and four in cities, including two managed by the police. Most highway stations (n=13) received one RTI call per day. Half of stations (n=5) were inside highway towns, usually near primary or secondary-level healthcare facilities. Travel time to the nearest tertiary healthcare facility ranged from 31 to 70 minutes (median=48 minutes; IQR=30–60). Other shortcomings noted for stations were not triaging RTI cases (86%), informing hospitals (64%), or recording response times (57%). All ambulances (n=12) had stretchers, but only 58% had oxygen cylinders. The median schooling of ambulance staff (n=13) was 8 years (IQR=3–10), and the median paramedic training was 3 days (IQR=2–3). Observed shortcomings in prehospital care could be improved by public-private partnerships focusing on paramedic training, making available essential medical supplies, and linking ambulance stations with designated healthcare facilities for appropriate RTI triage. PMID:24406963

Wisconsin Response to Intervention: A Guiding Document

ERIC Educational Resources Information Center

Wisconsin Department of Public Instruction, 2010

2010-01-01

To assist Wisconsin education leaders with planning for Response to Intervention (RtI), the Wisconsin Department of Public Instruction (DPI), in partnership with Wisconsin education stakeholders, has developed this informational brief. This brief is intended to provide guidance for implementation of RtI and should not be read as administrative…

RTI Strategies That Work in the K-2 Classroom

ERIC Educational Resources Information Center

Johnson, Eli; Karns, Michelle

2011-01-01

Targeted specifically to K-2 classrooms, the 25 Response-to-Intervention (RTI) strategies in this book are research-based and perfect for teachers who want to expand their toolbox of classroom interventions that work! Contents include: (1) Listening Strategies--Help students focus and understand; (2) Reading Strategies--Help students comprehend…

Practitioner Perceptions of Their Implementation of Response to Intervention (RTI)

ERIC Educational Resources Information Center

Perry, Yvonne D.

2012-01-01

The reauthorization of the Individuals with Disabilities Education Improvement Act of 2004 set in motion the movement away from the typical Referral/IQ Discrepancy Model of Exceptional Student Education identification toward the Response to Intervention (RtI) model for the identification of students with reading-related learning disabilities. This…

School Psychologists' Stages of Concern with RTI Implementation

ERIC Educational Resources Information Center

Bogue, Heidi; Marrs, Heath; Little, Suzanne

2017-01-01

Responsiveness to intervention has been an important change in models of service delivery within school systems in the recent past. However, there are a significant number of challenges to implementing the paradigm shift that these changes entail (Reschly 2008). Therefore, implementation of RTI varies among states, districts, and schools and some…

Grade One: Math Computation. Case Study #1

ERIC Educational Resources Information Center

Powell, Sarah R.; Seethaler, Pamela M.

2007-01-01

The purpose of this case study is to highlight the integral role that progress monitoring (PM) plays throughout any Response to Intervention (RTI) process. This example uses a three-level, responsiveness-to-intervention (RTI) method for identifying students with learning difficulties. Using a fictional first-grade classroom as the setting for…

A Collaborative Planning Framework for Teachers Implementing Tiered Instruction

ERIC Educational Resources Information Center

Stuart, Shannon K.; Rinaldi, Claudia

2009-01-01

The recent reauthorization and regulations of the Individuals With Disabilities Education Improvement Act (IDEA 2004) encourage the use of school-wide interventions including response to intervention (RTI; Bradley, Danielson, & Doolittle, 2007). RTI refers to a multi-tiered system that addresses the academic needs of all students by using…

What RTI Means for Content Area Teachers

ERIC Educational Resources Information Center

Lenski, Susan

2012-01-01

Response to Intervention (RTI) has the potential to have a positive impact on adolescent literacy by requiring content-area teachers to provide Tier 1 literacy instruction. This commentary suggests that content-area teachers can help their students improve their content knowledge and literacy skills by providing discipline-specific strategy…

Critical Practice Analysis of Special Education Policy: An RTI Example

ERIC Educational Resources Information Center

Thorius, Kathleen A. King; Maxcy, Brendan D.

2015-01-01

Since 1997, revisions to the Individuals With Disabilities Education Act (IDEA) have shown promise for addressing special education equity concerns: For example, states have the option to use response to intervention (RTI) for determining and thus reducing inappropriate disability determination, and states and districts are required to assess and…

Elementary General Education Teachers' Understanding of Response to Intervention

ERIC Educational Resources Information Center

Hunter, Ashly

2013-01-01

Legislation has mandated that schools provide instruction in the general education setting to students who are not performing on grade level by using a response to intervention (RTI) process and provide subsequent interventions. However, evidence suggests that teachers lack an understanding of RTI, which may impact implementation and the progress…

Use of Classification Agreement Analyses to Evaluate RTI Implementation

ERIC Educational Resources Information Center

VanDerHeyden, Amanda

2010-01-01

RTI as a framework for decision making has implications for the diagnosis of specific learning disabilities. Any diagnostic tool must meet certain standards to demonstrate that its use leads to predictable decisions with minimal risk. Classification agreement analyses are described as optimal for demonstrating the technical adequacy of RTI…

Response to Intervention Blueprints: District Level Edition

ERIC Educational Resources Information Center

Elliott, Judy; Morrison, Diane

2008-01-01

Response to Intervention (RtI) is the practice of providing high quality instruction and interventions matched to student need, monitoring progress frequently to make decisions about changes in instruction or goals and applying student response data to important educational decisions. RtI should be applied to decisions in general, remedial and…

Response to Intervention Blueprints: School Building Level Edition

ERIC Educational Resources Information Center

Kurns, Sharon; Tilly, W. David

2008-01-01

Response to Intervention (RtI) is the practice of providing high quality instruction and interventions matched to student need, monitoring progress frequently to make decisions about changes in instruction or goals and applying student response data to important educational decisions. RtI should be applied to decisions in general, remedial and…

A Comprehensive Approach to RtI: Embedding Universal Design for Learning and Technology

ERIC Educational Resources Information Center

Basham, James D.; Israel, Maya; Graden, Janet; Poth, Rita; Winston, Markay

2010-01-01

Response to intervention (RtI) provides tiered levels of supports to all students and allows for increasingly more intensive and individualized instruction. Similarly, universal design for learning (UDL) addresses needs of students by proactively planning for instructional, environmental, and technology supports to allow all students to…

RTI Scheduling Processes for Middle Schools. Information Brief

ERIC Educational Resources Information Center

Prewett, Sara; Mellard, Daryl; Lieske-Lupo, Jessica

2011-01-01

Response to intervention integrates assessment and intervention within a multi-level prevention system to maximize student achievement and to reduce behavior problems. With RTI, schools identify students at risk for poor learning outcomes, monitor student progress, provide evidence-based interventions and adjust the intensity and nature of those…

Examining Response to Intervention (RTI) Models in Secondary Education

ERIC Educational Resources Information Center

Epler, Pam, Ed.

2015-01-01

Response to Intervention (RTI) is an intervention model designed to assist all students regardless of their academic ability. It seeks to assist students who are struggling in academics by providing them with targeted assistance in the form of tutoring, pull-out services, and differentiated classroom instruction. "Examining Response to…

Tailoring Lessons for English-Learners

ERIC Educational Resources Information Center

Zehr, Mary Ann

2010-01-01

Educators in the Chula Vista Elementary School District determined what kind of instruction students needed through a "response to intervention" (RTI) process, which provides extra help to struggling students with an aim of reducing the number of referrals to special education. As RTI catches on throughout the country, the district is on…

PLCs, DI, & RTI: A Tapestry for School Change

ERIC Educational Resources Information Center

Stoehr, Judy; Banks, Maria; Allen, Linda

2011-01-01

Rather than buying individual books about professional learning communities (PLCs), differentiated instruction (DI), and Response to Intervention (RTI), invest wisely in one resource that synthesizes all three. The text uses a tapestry analogy to weave together these critical topics to form a comprehensive framework for achieving continuous school…

School Psychologists' Preferences on Response to Intervention

ERIC Educational Resources Information Center

Mike, Kristen

2010-01-01

As a result of the reauthorization of the Individuals with Disabilities Education Act (IDEA, 2004), Response to Intervention (RTI) became a legal and acceptable basis for determining special education eligibility. While there may be evidence that RTI has had positive effects on the prereferral process for special education in some schools, there…

Interventions at Windy Pines: Is RTI the Answer or the Problem?

ERIC Educational Resources Information Center

Thompson, Angela

2013-01-01

This case was written for educators who are involved in organizational change such as school turnaround, new instructional programs, intervention programs, and implementation of new programs. It explores how a new administrator navigates the implementation of a response to intervention (RTI) pilot program and how instructional leaders create…

Response to Intervention: The Future for Secondary Schools

ERIC Educational Resources Information Center

Canter, Andrea; Klotz, Mary Beth; Cowan, Katherine

2008-01-01

Response to intervention (RTI) program is a tiered process of implementing evidence-based instructional strategies in the regular education setting and frequently measuring the student's progress to determine whether these strategies are effective. The use of RTI methods as part of a comprehensive system to address student learning difficulties…

Applying Generalizability Theory for Making Quantitative RTI Progress-Monitoring Decisions

ERIC Educational Resources Information Center

Fan, Chung-Hau; Hansmann, Paul R.

2015-01-01

Language in the Individuals With Disabilities Education Improvement Act (IDEIA) allows the use of response-to-intervention (RTI) methodology in the identification of specific learning disabilities. However, there is no consensus on decision rules using curriculum-based measurement of oral reading fluency (CBM-R) for defining responsiveness. The…

Response to Intervention (RTI) Effectiveness in Kindergarten Reading Achievement

ERIC Educational Resources Information Center

Whittaker, Susan

2013-01-01

The purpose of this quantitative study was to determine whether kindergarten-reading achievement could be increased by implementing Response to Intervention (RtI) strategies. Kindergarten children (N = 290) who were identified as at-risk for reading difficulties were assigned to receive intervention through a) small reading groups (SRG), b)…

Epidemiology of Road Traffic Injuries in Qassim Region, Saudi Arabia: Consistency of Police and Health Data

PubMed Central

Barrimah, Issam; Midhet, Farid; Sharaf, Fawzi

2012-01-01

Introduction In Saudi Arabia, road traffic accidents (RTA) are becoming a serious public health problem. Police reports are designed for legal purposes with very little information on the health consequences. Also, health system data include detailed health information, but not related or linked to the data obtained police reports. Examining the consistency of these sources is vital to build an accurate surveillance system that can track the risk factors and the health consequences, as well as establishing and evaluating prevention interventions. Objectives This study is intended to: ▪ Examine the consistency of health -registration data with the data gathered by the traffic police department. ▪ Elucidate the magnitude, risk factors and outcome of RTI in Qassim region of Saudi Arabia, ▪ Compare the pattern of accidents in Qassim with those at different regions of the Kingdom. Methodology Health care information was collected on visits of victims of road traffic accidents to emergency and outpatients’ departments of the major hospitals in Qassim region during the year 2010. The information included the patients’ demographics, and clinical characteristics. Traffic Police Department information was also collected on all accidents that occurred in the study region. A Questionnaire was also developed and pilot tested to collect data from a random sample of population attending hospital outpatient and Primary Health Care clinics. Data included previous involvement in road traffic accident, and information about any injury; fatality or disability due to these RTI. Results During the study period, road traffic death rate based on death registration data was almost twice as high as the rate reported by the police (P < 0.05). There was also a significant decline of 27% according to police-reported data during the study period, as opposed to a non-significant increase of 8% according to health registration data during the same period. Population Survey Information showed the overall age-sex-adjusted rate for non-fatal RTI was 20.7 (95% CI, 20.0 – 21.3)/100 persons/year. The rate for non-fatal RTI is higher in the 10–19 years age group (17.3%). Males had twice or more incidence rate for RTI requiring recovery period of ≤ 7 days as compared with females, however, RTI incidence for recovery period of >7 days is more than twice in females.. Also a total of 12 deaths due to RTI were reported in 5–49 years age group in the last 3 years, representing an estimated annual RTI mortality rate of 35.4/100,000 (95% CI 16.6 – 57.8). A total of 11 participants reported RTI related disability in the last 3 years representing an estimated annual RTI disability rate of 34.1/100,000 population (95% CI 11.4 – 55.7). Reports of the Traffic Police Department showed that 18623 accidents occurred throughout the year 2010. These accidents involved 23178 persons, and resulted in the injury of 2025 people and the deaths of 369. In contrast, the health system reports showed that 4232 people had been injured and 1054 had died. Comparison with local & Arab Rates showed that Qassim is among the highest 5 regions in the kingdom regarding the number of RTA Saudi Arabia is also having a very high level of road traffic accidents and fatalities compared to other Arab countries. Conclusion RTI are responsible for significant loss of life, disability and injury in Qassim population and in Saudi Arabia. The inconsistency between police-reported data and health system data strongly suggests that active efforts to audit and monitor data quality are clearly necessary. PMID:23267302

Educators' Year Long Reactions to the Implementation of a Response to Intervention (RTI) Model

ERIC Educational Resources Information Center

Sanger, Dixie; Friedli, Corey; Brunken, Cindy; Snow, Pamela; Ritzman, Mitzi

2012-01-01

Mixed methods were used to explore the reactions of educators before and after implementing the Response to Intervention (RTI) model in secondary settings during a school year. Eighteen participants from six middle schools and four high schools collaborated on interdisciplinary teams that involved classroom teachers, speech-language pathologists…

Creating Meaning from Collaboration to Implement RtI for At-Risk Students

ERIC Educational Resources Information Center

Diakakis, Julia Ann

2014-01-01

The purpose of this qualitative exploratory case study based on Danielson's (2002) assertion that when teachers learn, student achievement improves was to examine how teachers created a collaborative learning experience through Professional Learning Community (PLC) concepts to implement Response to Intervention (RtI) with at-risk students. The…

Combining RTI and Psychoeducational Assessment: What We Must Assume to Do Otherwise

ERIC Educational Resources Information Center

Wodrich, David L.; Spencer, Marsha L. S.; Daley, Kelly B.

2006-01-01

The Individuals With Disabilities Education Improvement Act of 2004 (IDEA; 2004) permitted lack of students' response to intervention (RTI) to be considered as a basis for documenting specific learning disabilities (SLD). The previous method of detecting SLD, which relied on IQ and achievement testing, consequently is no longer mandatory.…

Building Your School's Capacity to Implement RTI: An ASCD Action Tool

ERIC Educational Resources Information Center

ASCD, 2011

2011-01-01

Once your school has established the reason and the will to move forward with Response to Intervention (RTI), you still have to navigate all the difficult steps of implementing core instruction with a multitiered system of supports, data-based problem solving, progress monitoring, and universal screening. That's where this ASCD (Association for…

Models for Implementing Response to Intervention: Tools, Outcomes, and Implications

ERIC Educational Resources Information Center

Shapiro, Edward S., Ed.; Zigmond, Naomi, Ed.; Wallace, Teri, Ed.; Marston, Doug, Ed.

2011-01-01

Providing a unique "on-the-ground" perspective, this book examines the implementation of three empirically supported response-to-intervention (RTI) models in four different school districts. The book addresses the complexity of putting RTI into place in the elementary grades, showing how the process actually took place and what impact it…

Assisting Students Struggling with Mathematics: Response to Intervention (RtI) for Elementary and Middle Schools. NCEE 2009-4060

ERIC Educational Resources Information Center

Gersten, Russell; Beckmann, Sybilla; Clarke, Benjamin; Foegen, Anne; Marsh, Laurel; Star, Jon R.; Witzel, Bradley

2009-01-01

Students struggling with mathematics may benefit from early interventions aimed at improving their mathematics ability and ultimately preventing subsequent failure. This guide provides eight specific recommendations intended to help teachers, principals, and school administrators use Response to Intervention (RtI) to identify students who need…

Pioneering RTI Systems that Work: Social Validity, Collaboration, and Context

ERIC Educational Resources Information Center

Mahdavi, Jennifer N.; Beebe-Frankenberger, Margaret E.

2009-01-01

Using collaborative teamwork to build unique response-to-intervention (RTI) systems responsive to the needs and strengths within their separate schools and communities, two Montana elementary schools forged a trail for other schools. Each school encountered different obstacles along the way as well as distinctive ways of defining success. How can…

Tier 2 Response to Intervention in Secondary Mathematics Education

ERIC Educational Resources Information Center

Bouck, Emily C.; Cosby, Missy D.

2017-01-01

Response to intervention (RtI) is increasingly being used in elementary and secondary schools both to provide early intervention and support to struggling students and to identify students who may benefit from special education. Although research exists to guide and support the implementation of RtI in elementary schools, much less information…

Action Research and Response to Intervention: Bridging the Discourse Divide

ERIC Educational Resources Information Center

Little, Mary E.

2012-01-01

The purpose of this article is to define and clarify the process of instructional problem-solving using assessment data within action research (AR) and Response to Intervention (RtI). Similarities between AR and RtI are defined and compared. Lastly, specific resources and examples of the instructional problem-solving process of AR within…

77 FR 53257 - Medicare Program; Hospital Inpatient Prospective Payment Systems for Acute Care Hospitals and the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... Electronic Device (CIED) Procedures c. New Candidate HAC Condition: Iatrogenic Pneumothorax With Venous Catheterization 6. RTI Program Evaluation Summary a. RTI Analysis of FY 2011 POA Indicator Reporting Across.... Hospital Inpatient Quality Reporting (IQR) Program 1. Background a. History of Measures Adopted for the...

Assessing Teacher Concerns Regarding Response to Instruction and Intervention

ERIC Educational Resources Information Center

McKinney, Darlene; Snead, Donald

2017-01-01

All individuals go through a process of change when implementing a new innovation. This descriptive study determines there is a difference in the stages of concern regarding Response to Instruction and Intervention (RTI), Tennessee's design model for Response to Intervention, (RTI) for 87 teachers from 8 different schools in a county in Middle…

Promoting Student Achievement through Educational Practices in Middle School Math Transitioning Classrooms

ERIC Educational Resources Information Center

Jackson, Viola Towels

2016-01-01

There is a plethora of research pertaining to Response to Intervention (RTI) implementation at the elementary school setting. However, research studies on teachers' perceptions relative to implementing RTI in a middle school tier-based classroom had not been conducted. The purpose of this qualitative case study was to examine teachers' perception…

Capitalizing on Curriculum-Based Measurement for Reading: Collaboration within a Response to Instruction Framework

ERIC Educational Resources Information Center

Weiss, Stacy L.; Friesen, Amber

2014-01-01

Response to Instruction (RTI) frameworks provide a structure for assessing student progress and evaluating the effectiveness of reading interventions. Schools frequently use RTI to support students who are struggling with learning to read while utilizing curriculum-based measurement (CBM) to monitor performance and guide instructional decisions…

When Leadership Matters: Perspectives from a Teacher Team Implementing Response to Intervention

ERIC Educational Resources Information Center

Meyer, Michele M.; Behar-Horenstein, Linda S.

2015-01-01

Previous research investigating the effectiveness of response to intervention (RTI) has relied on post hoc data analyses and surveys, although few studies have explored interactions among teacher teams. Understanding the synergistic impact of teacher work within the RTI framework may have implications for how school leaders can support teacher…

Evidence-Based Reading Practices for Response to Intervention

ERIC Educational Resources Information Center

Haager, Diane, Ed.; Klingner, Janette, Ed.; Vaughn, Sharon, Ed.

2007-01-01

In this volume, highly regarded authors in the field of reading research share what they know about today's hottest topic in education--Response to Intervention (RTI), the key to helping struggling students "before they fall behind." More than 30 expert contributors reveal what the latest research says about RTI's Three-Tier Approach:…

Preservice Training in Response to Intervention: Learning by Doing an Interdisciplinary Field Experience

ERIC Educational Resources Information Center

Hawkins, Renee O.; Kroeger, Stephen D.; Musti-Rao, Shobana; Barnett, David W.; Ward, Justine E.

2008-01-01

Marking major changes in professional role performance, response to intervention (RTI) is now in the Individuals with Disabilities Education Act (IDEA, 2004) as a possible method to improve the identification of specific learning disabilities. Moreover, RTI and related concepts and initiatives have fundamentally influenced more general methods of…

Response to Intervention Training: Theory into Practice for Sixth Grade Novice Teachers in Self-Contained Classrooms

ERIC Educational Resources Information Center

McMichel, Francita

2017-01-01

This qualitative case study examined the experiences from the professional development provided to four novice sixth grade teachers who employ reading interventions during Tier 2. Response to Intervention (RTI) is a systematic process that provides academic reading support to students through targeted interventions. RTI, when implemented…

Addressing Response to Intervention within Personnel Preparation Programs: Six Approaches. inForum

ERIC Educational Resources Information Center

Muller, Eve

2010-01-01

Response to Intervention (RTI), as a model for improving services to all students, has been a growing phenomenon since the reauthorization of the Individuals with Disabilities Education Act (IDEA) in 2004. The National Association of State Directors of Special Education (NASDSE) defines RTI as "the practice of (1) providing high-quality…

Environmental Technology Verification: Biological Inactivation Efficiency by HVAC In-Duct Ultraviolet Light Systems--American Ultraviolet Corporation, DC24-6-120 [EPA600etv08005

EPA Science Inventory

The Air Pollution Control Technology Verification Center (APCT Center) is operated by RTI International (RTI), in cooperation with EPA's National Risk Management Research Laboratory. The APCT Center conducts verifications of technologies that clean air in ventilation systems, inc...

Competing Views: A Dialogue on Response to Intervention

ERIC Educational Resources Information Center

Batsche, George M.; Kavale, Kenneth A.; Kovaleski, Joseph F.

2006-01-01

The provision for allowing local education agencies to use an assessment of a student's response to intervention (RTI) in lieu of a consideration of an ability--achievement discrepancy has been a controversial aspect of the 2004 Individuals with Disabilities Education Improvement Act. To address issues that have arisen about RTI, a series of…

Systemic Sustainability in RtI Using Intervention-Based Scheduling Methodologies

ERIC Educational Resources Information Center

Dallas, William P.

2017-01-01

This study evaluated a scheduling methodology referred to as intervention-based scheduling to address the problem of practice regarding the fidelity of implementing Response to Intervention (RtI) in an existing school schedule design. Employing panel data, this study used fixed-effects regressions and first differences ordinary least squares (OLS)…

Teacher Educators: Addressing the Needs of All Learners

ERIC Educational Resources Information Center

Cook, Ellen

2017-01-01

This qualitative dissertation examines how teacher preparation programs take up policy messages from two state agencies. These questions guided the study: (1) What are the messages about RTI and MTSS from the California Department of Education [CDE] and the California Commission on Teacher Credentialing [CCTC]; and (2) How are RtI and MTSS taken…

The Impact of Response to Intervention on Learning Disability Identification: School Based Practices

ERIC Educational Resources Information Center

Smith, Tina B.

2017-01-01

The "Response to Intervention Guidance for New York State School Districts" (2010) document indicates Response to Intervention (RTI) is a mandated general education process intended to provide early interventions to struggling at-risk students. The multi-level RTI framework is structured to include targeted evidence-based interventions…

Response to Intervention and Dynamic Assessment: Implementing Systematic, Dynamic and Individualised Interventions in Primary School

ERIC Educational Resources Information Center

Gustafson, Stefan; Svensson, Idor; Fälth, Linda

2014-01-01

In recent years, response to intervention (RTI) has been the focus of research, debate and educational implementations, especially regarding early reading instruction. RTI provides an educational framework characterised by different tiers or layers of instruction, providing increasingly more intense and individualised interventions for children in…

Response to Instruction in Preschool: Results of Two Randomized Studies with Children at Significant Risk of Reading Difficulties

ERIC Educational Resources Information Center

Lonigan, Christopher J.; Phillips, Beth M.

2016-01-01

Although response-to-instruction (RTI) approaches have received increased attention, few studies have evaluated the potential impacts of RTI approaches with preschool populations. This article presents results of 2 studies examining impacts of Tier II instruction with preschool children. Participating children were identified as substantially…

The School Implementation Scale: Measuring Implementation in Response to Intervention Models

ERIC Educational Resources Information Center

Erickson, Amy Gaumer; Noonan, Pattie M.; Jenson, Ronda

2012-01-01

Models of response to intervention (RTI) have been widely developed and implemented and have expanded to include integrated academic/behavior RTI models. Until recently, evaluation of model effectiveness has focused primarily on student-level data, but additional measures of treatment integrity within these multi-tiered models are emerging to…

Predicting First-Grade Reading Performance from Kindergarten Response to Tier 1 Instruction

ERIC Educational Resources Information Center

Al Otaiba, Stephanie; Folsom, Jessica S.; Schatschneider, Christopher; Wanzek, Jeanne; Greulich, Luana; Meadows, Jane; Li, Zhi; Connor, Carol M.

2011-01-01

Many schools are implementing multitier response-to-intervention (RTI) models to reduce reading difficulties. This study was part of our larger ongoing longitudinal RTI investigation within the Florida Learning Disabilities Center grant and was conducted in 7 ethnically and socioeconomically diverse schools. We observed reading instruction in 20…

Implementing RTI in a High School: A Case Study

ERIC Educational Resources Information Center

Fisher, Douglas; Frey, Nancy

2013-01-01

This case study chronicles the efforts of a small high school over a 2-year period as it designed and implemented a response to intervention (RTI) program for students at the school. Their efforts were largely successful, with improved achievement, attendance, and grade point averages and a decrease in special education referrals. Major themes…

Hydrodynamic scaling of the deceleration-phase Rayleigh–Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bose, A., E-mail: abos@lle.rochester.edu; Woo, K. M.; Betti, R.

2015-07-15

The scaling of the deceleration phase of inertial fusion direct-drive implosions is investigated for OMEGA and National Ignition Facility (NIF)-size targets. It is shown that the deceleration-phase Rayleigh–Taylor instability (RTI) does not scale hydro-equivalently with implosion size. This is because ablative stabilization resulting from thermal conduction and radiation transport in a spherically converging geometry is different on the two scales. As a consequence, NIF-scale implosions show lower hot-spot density and mass ablation velocity, allowing for higher RTI growth. On the contrary, stabilization resulting from density-gradient enhancement, caused by reabsorption of radiation emitted from the hot spot, is higher on NIFmore » implosions. Since the RTI mitigation related to thermal conduction and radiation transport scale oppositely with implosion size, the degradation of implosion performance caused by the deceleration RTI is similar for NIF and OMEGA targets. It is found that a minimum threshold for the no-α Lawson ignition parameter of χ{sub Ω} ≈ 0.2 at the OMEGA scale is required to demonstrate hydro-equivalent ignition at the NIF scale for symmetric direct-drive implosions.« less

Hydrodynamic scaling of the deceleration-phase Rayleigh–Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bose, A.; Woo, K. M.; Nora, R.

2015-07-02

The scaling of the deceleration phase of inertial fusion direct-drive implosions is investigated for OMEGA and National Ignition Facility (NIF)-size targets. It is shown that the deceleration-phase Rayleigh–Taylor instability (RTI) does not scale hydro-equivalently with implosion size. This is because ablative stabilization resulting from thermal conduction and radiation transport in a spherically converging geometry is different on the two scales. As a consequence, NIF-scale implosions show lower hot-spot density and mass ablation velocity, allowing for higher RTI growth. On the contrary, stabilization resulting from density-gradient enhancement, caused by reabsorption of radiation emitted from the hot spot, is higher on NIFmore » implosions. Since the RTI mitigation related to thermal conduction and radiation transport scale oppositely with implosion size, the degradation of implosion performance caused by the deceleration RTI is similar for NIF and OMEGA targets. It is found that a minimum threshold for the no-α Lawson ignition parameter of ΧΩ ≈ 0.2 at the OMEGA scale is required to demonstrate hydro-equivalent ignition at the NIF scale for symmetric direct-drive implosions.« less

Asymptotic behavior of the mixed mass in Rayleigh–Taylor and Richtmyer–Meshkov instability induced flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Ye; Cabot, William H.; Thornber, Ben

Rayleigh–Taylor instability (RTI) and Richtmyer–Meshkov instability (RMI) are serious practical issues in inertial confinement fusion research, and also have relevance to many cases of astrophysical fluid dynamics. So far, much of the attention has been paid to the late-time scaling of the mixed width, which is used as a surrogate to how well the fluids have been mixed. Yet, the actual amount of mixed mass could be viewed as a more direct indicator on the evolution of the mixing layers due to hydrodynamic instabilities. Despite its importance, there is no systematic study as yet on the scaling of the mixedmore » mass for either the RTI or the RMI induced flow. In this article, the normalized mixed mass (Ψ) is introduced for measuring the efficiency of the mixed mass. Six large numerical simulation databases have been employed: the RTI cases with heavy-to-light fluid density ratios of 1.5, 3, and 9; the single shock RMI cases with density ratios of 3 and 20; and a reshock RMI case with density ratio of 3. Using simulated flow fields, the normalized mixed mass Ψ is shown to be more sensitive in discriminating the variation with Atwood number for the RTI flows. Moreover, Ψ is demonstrated to provide more consistent results for both the RTI and RMI flows when compared with the traditional mixedness parameters, Ξ and Θ.« less

Smoke-free legislation and paediatric hospitalisations for acute respiratory tract infections: national quasi-experimental study with unexpected findings and important methodological implications.

PubMed

Been, Jasper V; Mackay, Daniel F; Millett, Christopher; Soyiri, Ireneous; van Schayck, Constant P; Pell, Jill P; Sheikh, Aziz

2017-10-27

We investigated whether Scottish implementation of smoke-free legislation was associated with a reduction in unplanned hospitalisations or deaths ('events') due to respiratory tract infections (RTIs) among children. Interrupted time series (ITS). Children aged 0-12 years living in Scotland during 1996-2012. National comprehensive smoke-free legislation (March 2006). Acute RTI events in the Scottish Morbidity Record-01 and/or National Records of Scotland Death Records. 135 134 RTI events were observed over 155 million patient-months. In our prespecified negative binomial regression model accounting for underlying temporal trends, seasonality, sex, age group, region, urbanisation level, socioeconomic status and seven-valent pneumococcal vaccination status, smoke-free legislation was associated with an immediate rise in RTI events (incidence rate ratio (IRR)=1.24, 95% CI 1.20 to 1.28) and an additional gradual increase (IRR=1.05/year, 95% CI 1.05 to 1.06). Given this unanticipated finding, we conducted a number of post hoc exploratory analyses. Among these, automatic break point detection indicated that the rise in RTI events actually preceded the smoke-free law by 16 months. When accounting for this break point, smoke-free legislation was associated with a gradual decrease in acute RTI events: IRR=0.91/year, 95% CI 0.87 to 0.96. Our prespecified ITS approach suggested that implementation of smoke-free legislation in Scotland was associated with an increase in paediatric RTI events. We were concerned that this result, which contradicted published evidence, was spurious. The association was indeed reversed when accounting for an unanticipated antecedent break point in the temporal trend, suggesting that the legislation may in fact be protective. ITS analyses should be subjected to comprehensive robustness checks to assess consistency. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Predictors of road traffic accident, road traffic injury and death among commercial motorcyclists in an urban area of Nigeria.

PubMed

Adogu, P O U; Ilika, A L; Asuzu, A L

2009-01-01

Road traffic accidents, injuries and deaths remain important public health problems in both developed and developing countries. These problems have since escalated with the introduction of the new phenomenon of commercial motorcycle transportation such as is found in the urbanizing slum of Nnewi, Anambra state of Nigeria. Using a semi-structured, interviewer-administered questionnaire, relevant data on socio-demographic and motorcycle characteristics were collected from a sample of 291 commercial motorcyclists selected by systematic sampling technique. Data on RTA, RTI and death were also collected from them overa period of three months. The result showed that young commercial motorcyclists {<30 years of age}, experienced higher fatal injury rate than older ones {> or =30 years of age}, {p < 0.01}. Motorcyclists with some formal education experienced RTA and RTI incidence rates that were significantly lower than those of motorcyclists with no formal education, {p < 0.01}. In the same vein, medical condition and social vices such as alcohol intake among the motorcyclists were found to be obvious predictors of RTA, RTI and death. Furthermore, motorcyclists who used >100 cc engine capacity motorcycles had significantly higher RTA incidence rate {478.8/100 MCY}, RTI rate {223.2/100 MCY} and FIR {410/100 MCY} than users of <100 cc engine motorcycles who recorded RTA incidence of 258.9/100 MCY, RTI rate of 49/100 MCY and zero fatal injury respectively {p < 0.01, p < 0.001, p < 0.001 respectively}. A careful consideration of all these predictors individually and collectively, will enable stakeholders in transport industry plan effective RTA, RTI and death control measures. Rather than an outright ban of motorcycle transportation, evening classes can be organized for the motorcyclists at subsidized rates to improve their literacy levels to run side by side with road safety informational lessons delivered at their places of work.

[An epidemiological survey on reproductive track infection and the investigation on syndromic approach on vaginal discharge].

PubMed

Liu, Min; Zeng, Guang; Zhang, Linghua; Liu, Zhiqiang; Li, Shiqin

2002-12-01

To investigate the reproductive track infection (RTI) situation and risk factors for cervical infection (Neisseria gonorrhoeae or Chlamydia trachomatis) among different kinds of women of childbearing age in Shenzhen city, China. To assess the feasibility of the syndromic approach for vaginal discharge. The survey was administrated to 4,744 eligible women in Shenzhen city during October 2001 and April 2002. The subjects included three different kinds of population: 3,895 cases of general population, 438 STD/gynecological clinic outpatients and 411 people with high risk behavior. Gynaecologic examination and RTI laboratory diagnosis were performed for each subject. PCR method-based test was used to detect the Neisseria gonorrhoeae and Chlamydia trachomatis infection. Standardized questionnaire were designed to collect the information about RTI related behaviors, and history of marriage and child bearing, et al. The risk factors, symptoms and signs of cervical infection were analyzed. Syndromic approach was established and its feasibility was assessed. 27.6% of women in Shenzhen were infected with at least one kind of RTI, including 5.0% with cervical infection. The risk factors for cervical infection were: individuals having had new sex partner within last 3 months (OR = 1.6, 95% CI: 1.1 - 2.4), having had the experience of abortion (OR = 1.6, 95% CI: 1.1 - 2.4), aged 25 or less (OR = 1.6, 95% CI: 1.1 - 2.4) and never using condom during sex intercourse (OR = 1.7, 95% CI: 1.1 - 2.4). The sensitivity of syndromic approach of risk assessment and signs for cervical infection among general population was 63.8%, while specificity was 55.1% with the positive predictive value 7.0%. RTI infection was common among all three kinds of childbearing women in Shenzhen city. The prevalence of RTI was the highest among high risk population, followed by STD/gynecological clinic outpatients. The efficacy of syndromic approach for cervical infection in general population was not ideal.

Clinical and microbiological evaluation of travel-associated respiratory tract infections in travelers returning from countries affected by pandemic A(H1N1) 2009 influenza.

PubMed

Jauréguiberry, Stéphane; Boutolleau, David; Grandsire, Eric; Kofman, Tomek; Deback, Claire; Aït-Arkoub, Zaïna; Bricaire, François; Agut, Henri; Caumes, Eric

2012-01-01

Although acute respiratory tract infections (RTI) have been recognized as a significant cause of illness in returning travelers, few studies have specifically evaluated the etiologies of RTI in this population. This prospective investigation evaluated travelers returning from countries with endemic influenza A(H1N1) 2009, and who were seen in our department at the onset of the outbreak (April-July 2009). Patients were included if they presented with signs of RTI that occurred during travel or less than 7 days after return from overseas travel. Patients were evaluated for microbial agents with RespiFinder plus assay, and throat culture according to clinical presentation. A total of 113 travelers (M/F ratio 1.2:1; mean age 39 y) were included. They were mainly tourists (n = 50; 44.2%) mostly returning from North America (n = 65; 58%) and Mexico (n = 21; 18.5%). The median duration of travel was 23 days (range 2-540 d). The median lag time between return and onset of illness was 0.2 days (range 10 d prior to 7 d after). The main clinical presentation of RTI was influenza-like illness (n = 76; 67.3%). Among the 99 microbiologically evaluated patients, a pathogen was found by polymerase chain reaction (PCR) or throat culture in 65 patients (65.6%). The main etiological agents were influenza A(H1N1) 2009 (18%), influenza viruses (14%), and rhinovirus (20%). A univariate analysis was unable to show variables associated with influenza A(H1N1) 2009, whereas rhinorrhea was associated with viruses other than influenza (p = 0.04). Despite the A(H1N1) 2009 influenza pandemic, rhinovirus and other influenza viruses were also frequent causes of RTI in overseas travelers. Real-time reverse transcription-PCR and nasopharyngeal swab cultures are useful diagnostic tools for evaluating travelers with RTI. © 2011 International Society of Travel Medicine.

The requirements and challenges in preventing of road traffic injury in Iran. A qualitative study.

PubMed

Khorasani-Zavareh, Davoud; Mohammadi, Reza; Khankeh, Hamid Reza; Laflamme, Lucie; Bikmoradi, Ali; Haglund, Bo J A

2009-12-23

Road traffic injuries (RTIs) are a major public health problem, especially in low- and middle-income countries. Among middle-income countries, Iran has one of the highest mortality rates from RTIs. Action is critical to combat this major public health problem. Stakeholders involved in RTI control are of key importance and their perceptions of barriers and facilitators are a vital source of knowledge. The aim of this study was to explore barriers to the prevention of RTIs and provide appropriate suggestions for prevention, based on the perceptions of stakeholders, victims and road-users as regards RTIs. Thirty-eight semi-structured interviews were conducted with informants in the field of RTI prevention including: police officers; public health professionals; experts from the road administrators; representatives from the General Governor, the car industry, firefighters; experts from Emergency Medical Service and the Red Crescent; and some motorcyclists and car drivers as well as victims of RTIs. A qualitative approach using grounded theory method was employed to analyze the material gathered. The core variable was identified as "The lack of a system approach to road-user safety". The following barriers in relation to RTI prevention were identified as: human factors; transportation system; and organizational coordination. Suggestions for improvement included education (for the general public and targeted group training), more effective legislation, more rigorous law enforcement, improved engineering in road infrastructure, and an integrated organization to supervise and coordinate preventive activities. The major barriers identified in this study were human factors and efforts to change human behaviour were suggested by means of public education campaigns and stricter law enforcement. However, the lack of a system approach to RTI prevention was also an important concern. There is an urgent need for both an integrated system to coordinate RTI activities and prevention and a major change in stakeholders' attitudes towards RTI prevention. The focus of all activities should take place on road users' safety.

A heuristic for efficient data distribution management in distributed simulation

NASA Astrophysics Data System (ADS)

Gupta, Pankaj; Guha, Ratan K.

2005-05-01

In this paper, we propose an algorithm for reducing the complexity of region matching and efficient multicasting in data distribution management component of High Level Architecture (HLA) Run Time Infrastructure (RTI). The current data distribution management (DDM) techniques rely on computing the intersection between the subscription and update regions. When a subscription region and an update region of different federates overlap, RTI establishes communication between the publisher and the subscriber. It subsequently routes the updates from the publisher to the subscriber. The proposed algorithm computes the update/subscription regions matching for dynamic allocation of multicast group. It provides new multicast routines that exploit the connectivity of federation by communicating updates regarding interactions and routes information only to those federates that require them. The region-matching problem in DDM reduces to clique-covering problem using the connections graph abstraction where the federations represent the vertices and the update/subscribe relations represent the edges. We develop an abstract model based on connection graph for data distribution management. Using this abstract model, we propose a heuristic for solving the region-matching problem of DDM. We also provide complexity analysis of the proposed heuristics.

Literacy Block: Meeting the Needs of All Learners; A Summative Program Evaluation

ERIC Educational Resources Information Center

Pelletier, Nancy L.

2011-01-01

This summative program evaluation study investigated the Response to Intervention (RTI) pilot literacy block program that was implemented in first and second grade classrooms in a small southeastern suburban school. All 111 students in the first and second grade were involved in this RTI model during the 2010-2011 school year including special…

Implementing Response to Intervention: Challenges of Diversity and System Change in a High Stakes Environment

ERIC Educational Resources Information Center

Cavendish, Wendy; Harry, Beth; Menda, Anne Maria; Espinosa, Anabel; Mahotiere, Margarette

2016-01-01

Background: The Response to Intervention (RTI) approach involves the use of a dynamic model built around the systematic documentation of students' response to research-based instructional interventions. Although there has been widespread implementation of RTI models for early intervention and in some cases, as a means to identify students with…

The Impact of Multi-Year Math Response to Intervention as Measured by Smarter Balanced Assessments

ERIC Educational Resources Information Center

Park, Maysoon Mohamad

2017-01-01

This quantitative study evaluated how two consecutive years of math Response to Intervention (RtI) demonstrated its effectiveness on 995 fifth grade students within the School District A (SDA) on Smarter Balanced (SB) assessments. Research questions: "What is the relationship between the duration of math RtI implementation and math…

Measuring the Implementation Fidelity of the Response to Intervention Framework in Milwaukee Public Schools. Stated Briefly. REL 2017-192

ERIC Educational Resources Information Center

Ruffini, Steffen J.; Lindsay, Jim; Miskell, Ryan; Proger, Amy

2016-01-01

Regional Educational Laboratory Midwest assisted Milwaukee Public Schools in developing a fidelity monitoring system for measuring schools' progress in implementing Response to Intervention (RTI). The study examined the ratings produced by that system to determine the system's reliability, schools' progress in implementing RTI, and whether ratings…

Examining the Potential for Response to Intervention (RTI) Delivery Models in Secondary Education: Emerging Research and Opportunities

ERIC Educational Resources Information Center

Epler, Pam

2017-01-01

To provide the highest quality of education to students, school administrators must adopt new frameworks to meet learners' needs. This allows teaching practices to be optimized to create a meaningful learning environment. "Examining the Potential for Response to Intervention (RTI) Delivery Models in Secondary Education: Emerging Research and…

Viewing Response-to-Intervention through an Educational Change Paradigm: What Can We Learn?

ERIC Educational Resources Information Center

Sansosti, Frank J.; Noltemeyer, Amity

2008-01-01

Response-to-Intervention (RtI), a framework for improving academic and behavioral outcomes for all students, can be viewed as a current example of an educational change initiative. Given the difficulties that some schools may be experiencing when implementing RtI effectively, it is important to examine prior educational change conceptualizations…

Response to Intervention: Where It Came from and Where It's Going

ERIC Educational Resources Information Center

Preston, Angela I.; Wood, Charles L.; Stecker, Pamela M.

2016-01-01

Response to intervention (RTI) emerged from the 2004 reauthorization of the Individuals with Disabilities Education Act, but the roots of RTI are found embedded within the history of the field of learning disabilities (LD) as well as other sources of influence. In what follows, we provide a brief history of LD and highlight the connection between…

Supporting Valid Decision Making: Uses and Misuses of Assessment Data within the Context of RtI

ERIC Educational Resources Information Center

Ball, Carrie R.; Christ, Theodore J.

2012-01-01

Within an RtI problem-solving context, assessment and decision making generally center around the tasks of problem identification, problem analysis, progress monitoring, and program evaluation. We use this framework to discuss the current state of the literature regarding curriculum based measurement, its technical properties, and its utility for…

Improving Responsiveness to Intervention in a Virtual Publically Supported Program: An Action Research

ERIC Educational Resources Information Center

Kerr, Rachel A.

2014-01-01

The purpose of this action research study was to design, implement, analyze, and evaluate a series of interventions to increase the elementary teachers' utilization of the RtI process. Another purpose of the study was to determine the teachers' background knowledge and perceptions about the Responsiveness to Intervention (RtI) process at the…

RTI Strategies That Work in the 3-6 Classroom

ERIC Educational Resources Information Center

Johnson, Eli; Karns, Michelle

2012-01-01

This is a must-have resource for educators committed to meeting the needs of their struggling students in Grades 3-6. Teachers get a whole toolbox filled with research-based, easy to implement RTI interventions that really work! Get strategies in five core areas--plus correlations to the Common Core State Standards and effective scaffolding tips…

The Legal Dimension of RTI--Confusion Confirmed: A Response to Walker and Daves

ERIC Educational Resources Information Center

Zirkel, Perry A.

2012-01-01

In this issue of "Learning Disability Quarterly" (LDQ), Professors Daves and Walker reply to my earlier LDQ article on confusion in the cases and commentary about the legal dimension of RTI. In this brief rejoinder, I show that their reply confirms rather than resolves the confusion in their original commentary in 2010. This persistent…

Academic Interventions and Academic Achievement in the Middle School Grades

ERIC Educational Resources Information Center

Kite, Toby G.

2015-01-01

After the passing of the Individuals with Disabilities Act of 2004, many schools began to use a Response to Intervention (RtI) model instead of the discrepancy model when identifying students with specific learning disabilities (National Center on Response to Intervention, 2011). When elementary schools adopted the RtI model, it was shown to be…

Relations between the CCSS and RTI in Literacy and Language

ERIC Educational Resources Information Center

Wixson, Karen K.; Lipson, Marjorie Y.

2012-01-01

Initiatives such as Response to Intervention (RTI) and the Common Core State Standards for English Language Arts (CCSS-ELA) have the potential to positively impact progress toward the goal of literacy for all. Because the CCSS-ELA will guide the content of the curriculum, instruction and assessment in the large number of adopting states, they will…

National Study of Postsecondary Faculty (NSOPF:04) Field Test Methodology Report, 2004. Working Paper Series. NCES 2004-01

ERIC Educational Resources Information Center

Heuer, R. E.; Cahalan, M.; Fahimi, M.; Curry-Tucker, J. L.; Carley-Baxter, L.; Curtin, T. R.; Hinsdale, M.; Jewell, D. M.; Kuhr, B. D.; McLean, L.

2004-01-01

The 2004 National Study of Postsecondary Faculty (NSOPF:04), conducted by RTI International (RTI) and sponsored by the U.S. Department of Education's National Center for Education Statistics (NCES), is a nationally representative study that collects data regarding the characteristics, workload, and career paths of full- and part-time…

Ethical and Legal Issues Associated with Using Response-to-Intervention to Assess Learning Disabilities

ERIC Educational Resources Information Center

Burns, Matthew K.; Jacob, Susan; Wagner, Angela R.

2008-01-01

The Individuals with Disabilities Education Improvement Act of 2004 allows schools to use a child's response to research-based intervention (RTI) as a part of procedures to identify students with learning disabilities. This paper considers whether RTI-based assessment models meet ethical and legal standards for acceptable assessment practices.…

Response to Intervention in Canada: Definitions, the Evidence Base, and Future Directions

ERIC Educational Resources Information Center

McIntosh, Kent; MacKay, Leslie D.; Andreou, Theresa; Brown, Jacqueline A.; Mathews, Susanna; Gietz, Carmen; Bennett, Joanna L.

2011-01-01

Based on challenges with the traditional model of school psychology, response to intervention (RTI) has been advanced as a model of special education eligibility decision making and service delivery that may address the drawbacks of the traditional models of assessment and result in improved outcomes for students. In this article, the RTI model is…

Identification of Reading Problems in First Grade within a Response-to-Intervention Framework

ERIC Educational Resources Information Center

Speece, Deborah L.; Schatschneider, Christopher; Silverman, Rebecca; Case, Lisa Pericola; Cooper, David H.; Jacobs, Dawn M.

2011-01-01

Models of Response to Intervention (RTI) include parameters of assessment and instruction. This study focuses on assessment with the purpose of developing a screening battery that validly and efficiently identifies first-grade children at risk for reading problems. In an RTI model, these children would be candidates for early intervention. We…

Teacher Empowerment in the Implementation of Response to Intervention: A Case Study

ERIC Educational Resources Information Center

Barge, Evie Taff

2012-01-01

Response to Intervention (RtI) is a data-driven process that supports the academic needs of students through targeted interventions to address specific identified areas of weakness. When implemented effectively, RtI aids students at the onset of learning concerns and can remediate learning problems which have, in the past, led to students being…

One Urban School's Implementation of a Systemic Response-to-Intervention (RTI) Framework

ERIC Educational Resources Information Center

Higgins Averill, Orla C.

2014-01-01

School districts have been attempting to implement the response-to-intervention (RTI) framework in an effort both to comply with federal legislation (i.e., IDEA 2004) and to improve teaching for all students. Extant research on this framework has focused on exploring assessment practices across tiers and the efficacy of specific interventions,…

Exploring the Relationship between Cognitive Characteristics and Responsiveness to a Tier 3 Reading Fluency Intervention

ERIC Educational Resources Information Center

Field, Stacey Allyson

2015-01-01

Current research suggests that certain cognitive functions predict the likelihood of intervention response for students who receive Tier 2 instruction through an RTI-framework. However, less is known about cognitive predictors of responder status at a theoretically more critical point of divergence within the RTI model: Tier 3. Moreover, no…

Perceptions of Pre-Service Teachers Regarding the Response-to-Intervention Model

ERIC Educational Resources Information Center

Arroyo, Kimberly A.

2014-01-01

A Response-to-Intervention (RTI) model of educational service delivery is a multi-tiered, preventative approach designed to meet the educational and behavioral needs of all learners. While the New York State (NYS) Department of Education has mandated the use of this model in grades K-4, the extent to which RTI competencies are taught within…

Selected Application of Response-to-Intervention Principles in College Courses: Possibilities and Limitations

ERIC Educational Resources Information Center

Blondin, Carolyn A.; Voils, Kyle; Galyon, Charles E.; Williams, Robert L.

2015-01-01

Concepts from the Response-to-Intervention (RTI) Model were used to promote a successful course outcome for students at risk for making low grades in an entry-level college course. The first exam served as a universal screener to identify students who could potentially benefit from RTI assistance. The researchers developed a tiered coaching…

The "Blurring" of Special Education in a New Continuum of General Education Placements and Services

ERIC Educational Resources Information Center

Fuchs, Douglas; Fuchs, Lynn S.; Stecker, Pamela M.

2010-01-01

For nearly 10 years, the response-to-intervention (RTI) policy initiative has engendered enthusiasm at federal, state, and local levels and among various stakeholders. Nevertheless, there are basic and important disagreements about its nature and purpose. The authors describe two groups with contrasting perspectives on RTI in an effort to examine…

Implementing Cycles of Assess, Plan, Do, Review: A Literature Review of Practitioner Perspectives

ERIC Educational Resources Information Center

Greenwood, Jo; Kelly, Catherine

2017-01-01

This article uses a literature review process to explore current literature on Response to Intervention (RtI), an approach to the identification of and provision for students with special educational needs introduced in the USA by the Individuals with Disabilities Education Improvement Act of 2004. Parallels are made between RtI and the graduated…

Wave Energy Prize - 1/50th Testing - RTI Wave Power

DOE Data Explorer

Wesley Scharmen

2015-12-18

This submission of data includes all the 1/50th scale testing data completed on the Wave Energy Prize for the RTI Wave Power team, and includes: 1/50th test data (raw & processed) 1/50th test data video and pictures 1/50th Test plans and testing documents SSTF_Submission (summarized results)

A Team-Based Approach to Improving Core Instructional Reading Practices within Response to Intervention

ERIC Educational Resources Information Center

Harlacher, Jason E.; Potter, Jon B.; Weber, Jill M.

2015-01-01

Core instruction is an important part of an effective response to intervention (RTI) model. To implement RTI effectively, school teams should regularly examine the effectiveness of their core instruction to determine if at least 80% of students meet the proficiency standard with core support alone. However, some educators may not have the skills…

Response to Intervention for Specific Learning Disabilities Identification: The Impact of Graduate Preparation and Experience on Identification Consistency

ERIC Educational Resources Information Center

Maki, Kathrin E.

2018-01-01

Response to intervention (RTI) is increasingly being implemented in schools as a means to identify students with specific learning disabilities (SLD). Despite its wide use, there is limited research regarding school psychologists' graduate preparation in and familiarity with RTI for SLD identification. This study examined how school psychologists'…

NHEXAS PHASE I REGION 5 STUDY--STANDARD OPERATING PROCEDURE--NHEXAS FILTER HANDLING, WEIGHING AND ARCHIVING PROCEDURES FOR AEROSOL SAMPLES (RTI/ACS-AP-209-011)

EPA Science Inventory

This protocol describes the procedures for weighing, handling, and archiving aerosol filters and for managing the associated analytical and quality assurance data. Filter samples were weighed for aerosol mass at RTI laboratory, with only the automated field sampling data transfer...

Identifying Head Start Children for Higher Tiers of Language and Literacy Instruction

ERIC Educational Resources Information Center

Albritton, Kizzy; Stuckey, Adrienne; Patton Terry, Nicole

2017-01-01

The application of Response to Intervention (RtI) to early childhood settings presents many opportunities and challenges; however, it remains unclear how best to implement this framework in settings in which children at risk of academic difficulty are overrepresented, like Head Start. One of the first steps in implementing any RtI process is the…

Mindfulness Practice: A Tier 1 Response to Intervention Strategy

ERIC Educational Resources Information Center

Lindsay-Simmons, Stacey A.

2011-01-01

Response to Intervention (RTI) is gaining ground. However, using RTI to assess the needs of students with behavioral problems is in its early stages. Teachers have limited tools at their disposal to use as Tier 1 strategies, such as classroom management strategies, or maybe a social skills curriculum taught once a week for 30 minutes. Research on…

Remediating Reading Difficulties in a Response to Intervention Model with Secondary Students

ERIC Educational Resources Information Center

Pyle, Nicole; Vaughn, Sharon

2012-01-01

The research on Response to Intervention (RtI) with secondary students is scant; however, a recently conducted, multiyear, large-scale implementation of RtI with middle-school students provides findings that inform practices and future directions for research. This article provides an overview of the findings from each of the 3 years of an…

The Effects of Response to Intervention (RTI) on Student Achievement in a Virtual High School

ERIC Educational Resources Information Center

Whittaker-Coleman, Tanya Rene

2017-01-01

This research study investigated whether the effects of response to intervention impacted student achievement in a rural virtual high school, as well as sought to determine staff perceptions of the efficacy of the implementation of RTI within the school. The researcher used both quantitative and qualitative analysis to effectively answer the…

The importance of measuring growth in response to intervention models: Testing a core assumption✩

PubMed Central

Schatschneider, Christopher; Wagner, Richard K.; Crawford, Elizabeth C.

2011-01-01

A core assumption of response to instruction or intervention (RTI) models is the importance of measuring growth in achievement over time in response to effective instruction or intervention. Many RTI models actively monitor growth for identifying individuals who need different levels of intervention. A large-scale (N=23,438), two-year longitudinal study of first grade children was carried out to compare the predictive validity of measures of achievement status, growth in achievement, and their combination for predicting future reading achievement. The results indicate that under typical conditions, measures of growth do not make a contribution to prediction that is independent of measures of achievement status. These results question the validity of a core assumption of RTI models. PMID:22224065

How to Use Equipment Specifications to Predict Measurement Uncertainty An Example Using Tunnels A, B and C Data System

DTIC Science & Technology

2012-06-01

µV RTI (relative to input) or ±1.0 mV RTO (relative to output). On a gain of 1,000, this is ±2.0 mV or ±0.02% FS and is a systematic error. Zero...Stability, Time: ±5 µV RTI, ±1.0 mV RTO . On a gain of 1,000, this is ±6 mV or ±0.06% FS. However, since the manufacturer’s specification is for 1-year...This is a random error assumed to be normally distributed. Zero Stability, Temperature: ±1 µV RTI, ±0.2 mV RTO /°C. On a gain of 1,000 and for a

Direct simulation Monte Carlo investigation of the Richtmyer-Meshkov instability

DOE PAGES

Gallis, Michail A.; Koehler, Timothy P.; Torczynski, John R.; ...

2015-08-14

The Rayleigh-Taylor instability (RTI) is investigated using the Direct Simulation Monte Carlo (DSMC) method of molecular gas dynamics. Here, fully resolved two-dimensional DSMC RTI simulations are performed to quantify the growth of flat and single-mode perturbed interfaces between two atmospheric-pressure monatomic gases as a function of the Atwood number and the gravitational acceleration. The DSMC simulations reproduce all qualitative features of the RTI and are in reasonable quantitative agreement with existing theoretical and empirical models in the linear, nonlinear, and self-similar regimes. At late times, the instability is seen to exhibit a self-similar behavior, in agreement with experimental observations. Formore » the conditions simulated, diffusion can influence the initial instability growth significantly.« less

Needs and Contradictions of a Changing Field: Evidence from a National Response to Intervention Implementation Study

ERIC Educational Resources Information Center

Patrikakou, Eva; Ockerman, Melissa S.; Hollenbeck, Amy Feiker

2016-01-01

As a result of the Response to Intervention (RTI) mandate in schools across many states, school counselors are well-positioned to take a leadership role. The present research study examines how school counselors across the nation perceived their training and knowledge of RTI, as well as their confidence in its implementation. Results indicate that…

Collaborative Inquiry: A Strategy for Assessing Response to Instruction and Intervention (RtI2) for English Learner Students

ERIC Educational Resources Information Center

Vineyard, Lynn

2010-01-01

This pilot study describes elementary teachers' use of collaborative inquiry as a strategy for assessing Response to Instruction and Intervention (RtI [superscript 2]) in reading for an English Learner student. The design of the study was based on the sociocultural theory that assessment practices shape teachers' understanding of students and of…

Professional Learning Communities: An Effective Mechanism for the Successful Implementation and Sustainability of Response to Intervention

ERIC Educational Resources Information Center

Mundschenk, Nancy A.; Fuchs, Wendy W.

2016-01-01

Models of response to intervention (RtI) are being widely implemented in schools across the country in order to increase effective teaching and remove barriers to student learning. The implementation of RtI is greatly facilitated when teachers and staff see themselves as a professional learning community (PLC). This article begins with an…

Emerging Opportunities for School Psychologists to Enhance our Remediation Procedure Evidence Base as We Apply Response to Intervention

ERIC Educational Resources Information Center

Skinner, Christopher H.; McCleary, Daniel F.; Skolits, Gary L.; Poncy, Brian C.; Cates, Gary L.

2013-01-01

The success of Response-to-Intervention (RTI) and similar models of service delivery is dependent on educators being able to apply effective and efficient remedial procedures. In the process of implementing problem-solving RTI models, school psychologists have an opportunity to contribute to and enhance the quality of our remedial-procedure…

RTI for Reading at the Secondary Level: Recommended Literacy Practices and Remaining Questions. What Works for Special-Needs Learners Series

ERIC Educational Resources Information Center

Reed, Deborah K.; Wexler, Jade; Vaughn, Sharon

2012-01-01

Grounded in the best current knowledge, this book shows how to implement response to intervention (RTI) in middle and high school contexts. Detailed guidelines are presented for teaching reading comprehension, vocabulary, and other aspects of literacy across the content areas, and for providing effective interventions for students who require…

Utilizing Response to Intervention (RtI) as a Means of Studying Capacity Building and Motivation of Staff by School Leadership Teams

ERIC Educational Resources Information Center

Mahoney, Brian J.

2013-01-01

This research study explored the concept of capacity building and motivation of staff by school leadership teams in the successful development and implementation of educational initiatives, specifically Response to Intervention (RtI). A great deal of scholarship has addressed leadership and its effect on motivation, but few studies have…

Response to Intervention (RtI) in the Social, Emotional, and Behavioral Domains: Current Challenges and Emerging Possibilities

ERIC Educational Resources Information Center

Saeki, Elina; Jimerson, Shane R.; Earhart, James; Hart, Shelley R.; Renshaw, Tyler; Singh, Renee D.; Stewart, Kaitlyn

2011-01-01

As many schools move toward a three-tier model that incorporates a Response to Intervention (RtI) service delivery model in the social, emotional, and behavioral domains, school psychologists may provide leadership. The decision-making process for filtering students through multiple tiers of support and intervention and examining change is an area…

NHEXAS PHASE I REGION 5 STUDY--QUALITY SYSTEMS AND IMPLEMENTATION PLAN FOR HUMAN EXPOSURE ASSESSMENT STUDY (RTI/5740/02-02QSIP)

EPA Science Inventory

The RTI/EOHSI Consortium scoping studies were designed to be part of the total NHEXAS framework that was developed as a result of a series scientific discussions and workshops conducted by the US EPA from 1992 through 1993. Several scientific issues needed to be addressed to eval...

Dynamic Assessment and Response to Intervention: Two Sides of One Coin

ERIC Educational Resources Information Center

Grigorenko, Elena L.

2009-01-01

This article compares and contrasts the main features of dynamic testing and assessment (DT/A) and response to intervention (RTI). The comparison is carried out along the following lines: (a) historical and empirical roots of both concepts, (b) premises underlying DT/A and RTI, (c) terms used in these concepts, (d) use of these concepts, (e)…

Elementary Teachers' Perspectives of the Implementation of Response to Intervention and Special Education Rates

ERIC Educational Resources Information Center

Dupuis, Susan D.

2010-01-01

Response to Intervention (RTI) employs a multi-tiered approach to providing targeted interventions for students who are at risk for school failure. With the reauthorization of the Individual with Disabilities Act (IDEA) 2004 and No Child Left Behind (NCLB) 2001 districts are given the option to implement RTI prior to student referral for special…

Achieving Science-Based Practice through Response to Intervention: What It Might Look Like in Preschools

ERIC Educational Resources Information Center

Barnett, David W.; VanDerHeyden, Amanda M.; Witt, Joseph C.

2007-01-01

The purpose of this manuscript is to conceptualize a unified Response to Intervention (RTI) model that may be applied to Head Starts or preschools with typical children and those identified as "at risk," or "children with disabilities." RTI basically provides a specific and discrete cumulative intervention history of services which also may be…

Measuring Response to Intervention: Comparing Three Effect Size Calculation Techniques for Single-Case Design Analysis

ERIC Educational Resources Information Center

Ross, Sarah Gwen

2012-01-01

Response to intervention (RTI) is increasingly being used in educational settings to make high-stakes, special education decisions. Because of this, the accurate use and analysis of single-case designs to monitor intervention effectiveness has become important to the RTI process. Effect size methods for single-case designs provide a useful way to…

Toward True Integration of Academic and Behavior Response to Intervention Systems: Part Two--Tier 2 Support

ERIC Educational Resources Information Center

McIntosh, Kent; Goodman, Steve; Bohanon, Hank

2010-01-01

In the previous article in this series, the authors provided a rationale for integrating academic and behavior response to intervention (RTI) systems. Their rationale included: (1) research showing that challenges in academic and social behavior are linked; (2) a description of the common features that both RTI systems share; and (3) the…

Response-to-Intervention in California Public Schools: Has It Helped Address Disproportional Placement Rates for Students with Learning Disabilities?

ERIC Educational Resources Information Center

Bouman, Sam H.

2010-01-01

Response-to-intervention (RTI) as applied in several California school districts was investigated by analyzing responses to questionnaires completed by 190 school psychologists representing 142 school districts. This analysis targeted the depth and breadth of RTI in these public K-12 school districts. A majority (80.7%) of the respondents…

The radiobrightness thermal inertia measure of soil moisture

NASA Technical Reports Server (NTRS)

England, Anthony W.; Galantowicz, John F.; Schretter, Mindy S.

1992-01-01

Radiobrightness thermal inertia (RTI) is proposed as a method for using day-night differences in satellite-sensed radiobrightness to monitor the moisture of Great Plains soils. Diurnal thermal and radiobrightness models are used to examine the sensitivity of the RTI method. Model predictions favor use of the 37.0 and 85.5 GHz, H-polarized channels of the Special Sensor Microwave/Imager (SSM/I). The model further predicts that overflight times near 2:00 AM/PM would be nearly optimal for RTI, that midnight/noon and 4:00 AM/PM are nearly as good, but that the 6:00 AM/PM overflight times of the current SSM/I are particularly poor. Data from the 37.0 GHz channel of the Scanning Multichannel Microwave Radiometer (SMMR) are used to demonstrate that the method is plausible.

The Use of Piecewise Growth Models to Estimate Learning Trajectories and RtI Instructional Effects in a Comparative Interrupted Time-Series Design

ERIC Educational Resources Information Center

Zvoch, Keith

2016-01-01

Piecewise growth models (PGMs) were used to estimate and model changes in the preliteracy skill development of kindergartners in a moderately sized school district in the Pacific Northwest. PGMs were applied to interrupted time-series (ITS) data that arose within the context of a response-to-intervention (RtI) instructional framework. During the…

A Team Approach to Data-Driven Decision-Making Literacy Instruction in Preschool Classrooms: Child Assessment and Intervention through Classroom Team Self-Reflection

ERIC Educational Resources Information Center

Abbott, Mary; Beecher, Constance; Petersen, Sarah; Greenwood, Charles R.; Atwater, Jane

2017-01-01

Many schools around the country are getting positive responses implementing Response to Intervention (RTI) within a Multi-Tiered System of Support (MTSS) framework (e.g., Abbott, 2011; Ball & Trammell, 2011; Buysee & Peisner-Feinberg, 2009). RTI refers to an instructional model that is based on a student's response to instruction. RTI…

Using Partially Observed Markov Decision Processes (POMDPs) to Implement a Response to Intervention (RTI) Framework for Early Reading

ERIC Educational Resources Information Center

Tokac, Umit

2016-01-01

The dissertation explored the efficacy of using a POMDP to select and apply appropriate instruction. POMDPs are a tool for planning: selecting a sequence of actions that will lead to an optimal outcome. RTI is an approach to instruction, where teachers craft individual plans for students based on the results of screening test. The goal is to…

Supporting Early Grades Student Achievement: An Exploration of RTI[superscript 2] Practices. Tennessee RTI[superscript 2] Model

ERIC Educational Resources Information Center

Stone, Zachary

2016-01-01

Almost half of Tennessee's students are not on grade level in reading and math by the time they complete third grade, and very few of those students achieve proficiency in later grades. To combat this trend and support the skill development and academic achievement of all students, Tennessee has adopted a framework for addressing individual…

Measuring Educators' Perceptions of Their Skills Relative to Response to Intervention: A Psychometric Study of a Survey Tool

ERIC Educational Resources Information Center

Castillo, Jose M.; March, Amanda L.; Stockslager, Kevin M.; Hines, Constance V.

2016-01-01

The "Perceptions of RtI Skills Survey" is a self-report measure that assesses educators' perceptions of their data-based problem-solving skills--a critical element of many Response-to-Intervention (RtI) models. Confirmatory factor analysis (CFA) was used to evaluate the underlying factor structure of this tool. Educators from 68 (n =…

The RTI Daily Planning Book, K-6: Tools and Strategies for Collecting and Assessing Reading Data & Targeted Follow-Up Instruction

ERIC Educational Resources Information Center

Owocki, Gretchen

2010-01-01

Children's needs differ so vastly that a single program designed to support numerous students can only do so much. More than anything else, students need to use professional expertise to unravel their needs and to plan instruction that is directly responsive. This book makes exemplary RTI possible in every reading classroom. The author gives you…

Recognition & Response: Developing and Evaluating a Model of RTI for Pre-K

ERIC Educational Resources Information Center

Buysse, Virginia; Peisner-Feinberg, Ellen; Burchinal, Margaret

2012-01-01

The Recognition & Response (R&R) model was developed and is being validated by a research team at the FPG Child Development Institute at the University of North Carolina at Chapel Hill. R&R has generated widespread attention in the early childhood field as a promising RTI model for pre-k (see entire issue of NHSA Dialog, Volume 12[3],…

What Is the Evidence Base to Support Reading Interventions for Improving Student Outcomes in Grades 1-3? REL 2017-271

ERIC Educational Resources Information Center

Gersten, Russell; Newman-Gonchar, Rebecca; Haymond, Kelly S.; Dimino, Joseph

2017-01-01

Response to intervention (RTI) is a comprehensive early detection and prevention strategy used to identify and support struggling students before they fall behind. An RTI model usually has three tiers or levels of support. Tier 1 is generally defined as classroom instruction provided to all students, tier 2 is typically a preventive intervention…

The Effects of Tier One RtI at the Elementary School Level Using I-Station on Reading Text Fluency

ERIC Educational Resources Information Center

Lundin, Meredith M.

2017-01-01

This study looked at the effects of Tier 1 Response to Intervention (RtI) on elementary school reading fluency using I-Station assessment and intervention. The study included four elementary schools within the same school district that represented the four quadrants of the school district so that a variety of factors and the district's demographic…

Response to Intervention A Systematic Process to Increase Learning Outcomes for All Students. Guidance Document for New Mexico Schools

ERIC Educational Resources Information Center

New Mexico Public Education Department, 2006

2006-01-01

Response to Intervention (RtI) is the practice of providing high-quality instruction and interventions to meet student needs and monitor progress in order to ensure effectiveness of instruction and/or interventions. RtI is an integrated service delivery approach for all students and should be applied to decisions in general, remedial, and special…

Response to Intervention (RTI): A Mixed Methods Study Evaluating the Effects of Behavior Training Software on Behavior of In-School Suspension Students

ERIC Educational Resources Information Center

Cooper, Rosie Nicole

2014-01-01

Excessive classroom disruption is prevalent among today's public high schools and is a deterrent to the academic and social achievements of students. Using Response to Intervention (RtI) to equip in-school suspension (ISS) programs with a research-based behavioral curriculum is one possible solution to efficiently and cost-effectively remediating…

Accelerating Chronically Unresponsive Children to Tier 3 Instruction: What Level of Data Is Necessary to Ensure Selection Accuracy?

ERIC Educational Resources Information Center

Compton, Donald L.; Gilbert, Jennifer K.; Jenkins, Joseph R.; Fuchs, Douglas; Fuchs, Lynn S.; Cho, Eunsoo; Barquero, Laura A.; Bouton, Bobette

2012-01-01

Response-to-intervention (RTI) approaches to disability identification are meant to put an end to the so-called wait-to-fail requirement associated with IQ discrepancy. However, in an unfortunate irony, there is a group of children who wait to fail in RTI frameworks. That is, they must fail both general classroom instruction (Tier 1) and…

Building Level Principals as Change Agents in a Response to Intervention Reform Initiative

ERIC Educational Resources Information Center

Ninni, Kristen

2010-01-01

The purpose of this study was to examine the role of the principal in a systems change effort. Utilizing Response to Intervention (RtI) as a means of studying principals as change agents, this researcher examined the principals' ability to implement and sustain a reform effort such as RtI as perceived by the principal, problem solving team, and…

Health services for reproductive tract infections among female migrant workers in industrial zones in Ha Noi, Viet Nam: an in-depth assessment

PubMed Central

2012-01-01

Background Rural-to-urban migration involves a high proportion of females because job opportunities for female migrants have increased in urban industrial areas. Those who migrate may be healthier than those staying in the village and they may benefit from better health care services at destination, but the 'healthy' effect can be reversed at destination due to migration-related health risk factors. The study aimed to explore the need for health care services for reproductive tract infections (RTIs) among female migrants working in the Sai Dong industrial zone as well as their services utilization. Methods The cross sectional study employed a mixed method approach. A cohort of 300 female migrants was interviewed to collect quantitative data. Two focus groups and 20 in-depth interviews were conducted to collect qualitative data. We have used frequency and cross-tabulation techniques to analyze the quantitative data and the qualitative data was used to triangulate and to provide more in-depth information. Results The needs for health care services for RTI were high as 25% of participants had RTI syndromes. Only 21.6% of female migrants having RTI syndromes ever seek helps for health care services. Barriers preventing migrants to access services were traditional values, long working hours, lack of information, and high cost of services. Employers had limited interests in reproductive health of female migrants, and there was ineffective collaboration between the local health system and enterprises. These barriers were partly caused by lack of health promotion programs suitable for migrants. Most respondents needed more information on RTIs and preferred to receive these from their employers since they commonly work shifts - and spend most of their day time at work. Conclusion While RTIs are a common health problem among female migrant workers in industrial zones, female migrants had many obstacles in accessing RTI care services. The findings from this study will help to design intervention models for RTI among this vulnerable group such as communication for behavioural impact of RTI health care, fostered collaboration between local health care services and employer enterprises, and on-site service (e.g. local or enterprise health clinics) strengthening. PMID:22369718

Novel models and algorithms of load balancing for variable-structured collaborative simulation under HLA/RTI

NASA Astrophysics Data System (ADS)

Yue, Yingchao; Fan, Wenhui; Xiao, Tianyuan; Ma, Cheng

2013-07-01

High level architecture(HLA) is the open standard in the collaborative simulation field. Scholars have been paying close attention to theoretical research on and engineering applications of collaborative simulation based on HLA/RTI, which extends HLA in various aspects like functionality and efficiency. However, related study on the load balancing problem of HLA collaborative simulation is insufficient. Without load balancing, collaborative simulation under HLA/RTI may encounter performance reduction or even fatal errors. In this paper, load balancing is further divided into static problems and dynamic problems. A multi-objective model is established and the randomness of model parameters is taken into consideration for static load balancing, which makes the model more credible. The Monte Carlo based optimization algorithm(MCOA) is excogitated to gain static load balance. For dynamic load balancing, a new type of dynamic load balancing problem is put forward with regards to the variable-structured collaborative simulation under HLA/RTI. In order to minimize the influence against the running collaborative simulation, the ordinal optimization based algorithm(OOA) is devised to shorten the optimization time. Furthermore, the two algorithms are adopted in simulation experiments of different scenarios, which demonstrate their effectiveness and efficiency. An engineering experiment about collaborative simulation under HLA/RTI of high speed electricity multiple units(EMU) is also conducted to indentify credibility of the proposed models and supportive utility of MCOA and OOA to practical engineering systems. The proposed research ensures compatibility of traditional HLA, enhances the ability for assigning simulation loads onto computing units both statically and dynamically, improves the performance of collaborative simulation system and makes full use of the hardware resources.

Reducing antibiotic prescriptions for respiratory tract infections in family practice: results of a cluster randomized controlled trial evaluating a multifaceted peer-group-based intervention.

PubMed

Vervloet, Marcia; Meulepas, Marianne A; Cals, Jochen W L; Eimers, Mariëtta; van der Hoek, Lucas S; van Dijk, Liset

2016-02-04

Irrational antibiotic use for respiratory tract infections (RTI) is a major driver of bacterial resistance. The aim of this study was to evaluate the effect of a multifaceted peer-group based intervention aiming to reduce RTI-related antibiotic prescriptions in family practice. This was a cluster randomized controlled trial with pre- and follow-up measurement. The intervention was implemented through PharmacoTherapy Audit Meetings (PTAM) in which family physicians (FPs) and pharmacists collaborate. Four PTAM groups received the intervention consisting of: (1) FP communication skills training, including communication about delayed prescribing; (2) implementation of antibiotic prescribing agreements in FPs' Electronic Prescribing Systems; (3) quarterly feedback figures for FPs. Four other PTAM groups were matched controls. Primary outcome measure was the number of RTI-related antibiotic prescriptions after the intervention, assessed with multilevel linear regression analyses. Total number and number of prescriptions stratified by age (under/over 12 years) were analysed. At baseline, the average total number of RTI-related antibiotic prescriptions per 1,000 patients was 207.9 and 176.7 in the intervention and control PTAM groups, respectively. At follow-up, FPs in both the intervention and control groups prescribed significantly less antibiotics. For adolescents and adults, the drop in number of antibiotic prescription was significantly larger in the intervention groups (-27.8 per 1,000 patients) than the control groups (-7.2 per 1,000 patients; P<0.05). This multifaceted peer-group-based intervention was effective in reducing the number of RTI-related antibiotic prescriptions for adolescents and adults. To affect antibiotic prescribing in children other methods are needed.

Teaching children road safety through storybooks: an approach to child health literacy in Pakistan.

PubMed

Ahmad, Haris; Naeem, Rubaba; Feroze, Asher; Zia, Nukhba; Shakoor, Amarah; Khan, Uzma Rahim; Mian, Asad Iqbal

2018-02-07

Road traffic injuries (RTIs) commonly affect the younger population in low- and-middle-income countries. School children may be educated about road safety using storybooks with colorful pictures, which tends to increase the child's interest in the text. Therefore, this study assessed the use of bilingual pictorial storybooks to improve RTI prevention knowledge among school children. This pretest-posttest study was conducted in eight public and nine private schools of Karachi, Pakistan, between February to May 2015. Children in grades four and five were enrolled at baseline (n = 410). The intervention was an interactive discussion about RTI prevention using a bilingual (Urdu and English) pictorial storybook. A baseline test was conducted to assess children's pre-existing knowledge about RTI prevention followed by administration of the intervention. Two posttests were conducted: first immediately after the intervention, and second after 2 months. Test scores were analyzed using McNemar test and paired sample t-test. There were 57% girls and 55% public school students; age range 8-16 years. Compared to the overall baseline score (5.1 ± 1.4), the number of correct answers increased in both subsequent tests (5.9 ± 1.2 and 6.1 ± 1.1 respectively, p-value < 0.001). Statistically significant improvement in mean scores was observed based on gender, grades and school type over time (p-value < 0.001). Discussions using bilingual pictorial storybooks helped primary school children in Pakistan grasp knowledge of RTI prevention. RTI education sessions may be incorporated into school curricula using storybooks as teaching tools. Potential exists to create similar models for other developing countries by translating the storybooks into local languages.

Elementary School Psychologists' Perceptions of Response to Intervention and Its Use to Diagnose Students with Specific Learning Disabilities in Tennessee: A Mixed Methods Study

ERIC Educational Resources Information Center

Ebbinger, April M.

2017-01-01

The purpose of this study was to examine the changes in initial eligibilities of elementary students across Tennessee since the implementation response to intervention (RtI), as well as understand the perceptions of elementary school psychologists related to those changes in identification and eligibility. RtI is a Tennessee mandated initiative,…

Perceived Effects of North Carolina's Response to Intervention Process on School Counselor's Professional Duties and Responsiblities: A Correlational Study

ERIC Educational Resources Information Center

Bookard, Katina L.

2014-01-01

The purpose of this correlational study was to test to see if there was a relationship between time reduction of the roles and responsibilities of a school counselor and the Response to Intervention (RTI) process in an elementary school setting. This study examined the perceived effects of the RTI process on the roles and responsibilities of a…

Confidence intervals for single-case effect size measures based on randomization test inversion.

PubMed

Michiels, Bart; Heyvaert, Mieke; Meulders, Ann; Onghena, Patrick

2017-02-01

In the current paper, we present a method to construct nonparametric confidence intervals (CIs) for single-case effect size measures in the context of various single-case designs. We use the relationship between a two-sided statistical hypothesis test at significance level α and a 100 (1 - α) % two-sided CI to construct CIs for any effect size measure θ that contain all point null hypothesis θ values that cannot be rejected by the hypothesis test at significance level α. This method of hypothesis test inversion (HTI) can be employed using a randomization test as the statistical hypothesis test in order to construct a nonparametric CI for θ. We will refer to this procedure as randomization test inversion (RTI). We illustrate RTI in a situation in which θ is the unstandardized and the standardized difference in means between two treatments in a completely randomized single-case design. Additionally, we demonstrate how RTI can be extended to other types of single-case designs. Finally, we discuss a few challenges for RTI as well as possibilities when using the method with other effect size measures, such as rank-based nonoverlap indices. Supplementary to this paper, we provide easy-to-use R code, which allows the user to construct nonparametric CIs according to the proposed method.

NASA technology applications team: Applications of aerospace technology

NASA Technical Reports Server (NTRS)

1993-01-01

This report covers the activities of the Research Triangle Institute (RTI) Technology Applications Team for the period 1 October 1992 through 30 September 1993. The work reported herein was supported by the National Aeronautics and Space Administration (NASA), Contract No. NASW-4367. Highlights of the RTI Applications Team activities over the past year are presented in Section 1.0. The Team's progress in fulfilling the requirements of the contract is summarized in Section 2.0. In addition to our market-driven approach to applications project development, RTI has placed increased effort on activities to commercialize technologies developed at NASA Centers. These Technology Commercialization efforts are summarized in Section 3.0. New problem statements prepared by the Team in the reporting period are presented in Section 4.0. The Team's transfer activities for ongoing projects with the NASA Centers are presented in Section 5.0. Section 6.0 summarizes the status of four add-on tasks. Travel for the reporting period is described in Section 7.0. The RTI Team staff and consultants and their project responsibilities are listed in Appendix A. Appendix B includes Technology Opportunity Announcements and Spinoff! Sheets prepared by the Team while Appendix C contains a series of technology transfer articles prepared by the Team.

The Extent to Which Response to Intervention Exists in Reading in K-2 Spanish Dual Language Immersion Classrooms in a Wisconsin School District

ERIC Educational Resources Information Center

Chaja-Clardy, Sarah R.

2016-01-01

Bilingual programs continue to expand in school districts across the United States to address the growing numbers of students whose home language is other than English. The Response to Intervention (RTI) framework was used to guide this qualitative study, the purpose of which was to identify the extent to which the five elements of RTI exist in…

An HLA-Based Approach to Quantify Achievable Performance for Tactical Edge Applications

DTIC Science & Technology

2011-05-01

in: Proceedings of the 2002 Fall Simulation Interoperability Workshop, 02F- SIW -068, Nov 2002. [16] P. Knight, et al. ―WBT RTI Independent...Benchmark Tests: Design, Implementation, and Updated Results‖, in: Proceedings of the 2002 Spring Simulation Interoperability Workshop, 02S- SIW -081, March...Interoperability Workshop, 98F- SIW -085, Nov 1998. [18] S. Ferenci and R. Fujimoto. ―RTI Performance on Shared Memory and Message Passing Architectures‖, in

Intensified hand-hygiene campaign including soap-and-water wash may prevent acute infections in office workers, as shown by a recognized-exposure -adjusted analysis of a randomized trial.

PubMed

Hovi, Tapani; Ollgren, Jukka; Savolainen-Kopra, Carita

2017-01-09

Variable exposure to causative agents of acute respiratory (RTI) or gastrointestinal tract infections (GTI) is a significant confounding factor in the analysis of the efficacy of interventions concerning these infections. We had an exceptional opportunity to reanalyze a previously published dataset from a trial assessing the effect of enhanced hand hygiene on the occurrence of RTI or GTI in adults, after adjustment for reported exposure and other covariates. Twenty-one working units (designated clusters) each including at least 50 office employees, totaling 1,270 persons, were randomized into two intervention arms (either using water-and-soap or alcohol-rub in hand cleansing), or in the control arm. Self-reported data was collected through weekly emails and included own symptoms of RTI or GTI, and exposures to other persons with similar symptoms. Differences in the weekly occurrences of RTI and GTI symptoms between the arms were analyzed using multilevel binary regression model with log link with personal and cluster specific random effects, self-reported exposure to homologous disease, randomization triplet, and seasonality as covariates in the Bayesian framework. Over the 16 months duration of the trial, 297 persons in the soap and water arm, 238 persons in the alcohol-based hand rub arm, and 230 controls sent reports. The arms were similar in age distribution and gender ratios. A temporally-associated reported exposure strongly increased the risk of both types of infection in all trial arms. Persons in the soap-and-water arm reported a significantly - about 24% lower weekly prevalence of GTI than the controls whether they had observed an exposure or not during the preceding week, while for RTI, this intervention reduced the prevalence only during weeks without a reported exposure. Alcohol-rub did not affect the symptom prevalence. We conclude that while frequent and careful hand washing with soap and water partially protected office-working adults from GTI, the effect on RTI was only marginal in this study. Potential reasons for this difference include partially different transmission routes and a difference in the virus load. In this trial, frequent standardized hand rubbing with ethanol-based disinfectant did not reduce the weekly prevalence of either type of infections. ClinicalTrials.gov Identifier: NCT00821509, 12 March 2009.

The Effect of the Dynamic Skills Protocol RTI Model on Reading Achievement in an Elementary School and the Predictive Validity of Phonics Screening Measures Implemented in the Model

ERIC Educational Resources Information Center

Laben, Joyce

2012-01-01

With the implementation of RTI, educators are attempting to find models that are the best fit for their schools. The problem solving and standard protocol models are the two most common. This study of 65 students examines a new model, the dynamic skills protocol implemented in an elementary school starting in their fourth quarter of kindergarten…

Quantification of Listeria monocytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16S rRNA real-time PCR.

PubMed

Aparecida de Oliveira, Maria; Abeid Ribeiro, Eliana Guimarães; Morato Bergamini, Alzira Maria; Pereira De Martinis, Elaine Cristina

2010-02-01

Modern lifestyle markedly changed eating habits worldwide, with an increasing demand for ready-to-eat foods, such as minimally processed fruits and leafy greens. Packaging and storage conditions of those products may favor the growth of psychrotrophic bacteria, including the pathogen Listeria monocytogenes. In this work, minimally processed leafy vegetables samples (n = 162) from retail market from Ribeirão Preto, São Paulo, Brazil, were tested for the presence or absence of Listeria spp. by the immunoassay Listeria Rapid Test, Oxoid. Two L. monocytogenes positive and six artificially contaminated samples of minimally processed leafy vegetables were evaluated by the Most Probable Number (MPN) with detection by classical culture method and also culture method combined with real-time PCR (RTi-PCR) for 16S rRNA genes of L. monocytogenes. Positive MPN enrichment tubes were analyzed by RTi-PCR with primers specific for L. monocytogenes using the commercial preparation ABSOLUTE QPCR SYBR Green Mix (ABgene, UK). Real-time PCR assay presented good exclusivity and inclusivity results and no statistical significant difference was found in comparison with the conventional culture method (p < 0.05). Moreover, RTi-PCR was fast and easy to perform, with MPN results obtained in ca. 48 h for RTi-PCR in comparison to 7 days for conventional method.

Informing road traffic intervention choices in South Africa: the role of economic evaluations

PubMed Central

Wesson, Hadley K.H.; Boikhutso, Nkuli; Hyder, Adnan A.; Bertram, Melanie; Hofman, Karen J.

2016-01-01

Introduction Given the burden of road traffic injuries (RTIs) in South Africa, economic evaluations of prevention interventions are necessary for informing and prioritising public health planning and policy with regard to road safety. Methods In view of the dearth of RTI cost analysis, and in order to understand the extent to which RTI-related costs in South Africa compare with those in other low- and middle-income countries (LMICs), we reviewed published economic evaluations of RTI-related prevention in LMICs. Results Thirteen articles were identified, including cost-of-illness and cost-effectiveness studies. Although RTI-related risk factors in South Africa are well described, costing studies are limited. There is minimal information, most of which is not recent, with nothing at all on societal costs. Cost-effective interventions for RTIs in LMICs include bicycle and motorcycle helmet enforcement, traffic enforcement, and the construction of speed bumps. Discussion Policy recommendations from studies conducted in LMICs suggest a number of cost-effective interventions for consideration in South Africa. They include speed bumps for pedestrian safety, strategically positioned speed cameras, traffic enforcement such as the monitoring of seatbelt use, and breathalyzer interventions. However, interventions introduced in South Africa will need to be based either on South African cost-effectiveness data or on findings adapted from similar middle-income country settings. PMID:27396485

Emergence of a New Population of Rathayibacter toxicus: An Ecologically Complex, Geographically Isolated Bacterium

PubMed Central

Arif, Mohammad; Busot, Grethel Y.; Mann, Rachel; Rodoni, Brendan; Liu, Sanzhen; Stack, James P.

2016-01-01

Rathayibacter toxicus is a gram-positive bacterium that infects the floral parts of several Poaceae species in Australia. Bacterial ooze is often produced on the surface of infected plants and bacterial galls are produced in place of seed. R. toxicus is a regulated plant pathogen in the U.S. yet reliable detection and diagnostic tools are lacking. To better understand this geographically-isolated plant pathogen, genetic variation as a function of geographic location, host species, and date of isolation was determined for isolates collected over a forty-year period. Discriminant analyses of recently collected and archived isolates using Multi-Locus Sequence Typing (MLST) and Inter-Simple Sequence Repeats (ISSR) identified three populations of R. toxicus; RT-I and RT-II from South Australia and RT-III from Western Australia. Population RT-I, detected in 2013 and 2014 from the Yorke Peninsula in South Australia, is a newly emerged population of R. toxicus not previously reported. Commonly used housekeeping genes failed to discriminate among the R. toxicus isolates. However, strategically selected and genome-dispersed MLST genes representing an array of cellular functions from chromosome replication, antibiotic resistance and biosynthetic pathways to bacterial acquired immunity were discriminative. Genetic variation among isolates within the RT-I population was less than the within-population variation for the previously reported RT-II and RT-III populations. The lower relative genetic variation within the RT-I population and its absence from sampling over the past 40 years suggest its recent emergence. RT-I was the dominant population on the Yorke Peninsula during the 2013–2014 sampling period perhaps indicating a competitive advantage over the previously detected RT-II population. The potential for introduction of this bacterial plant pathogen into new geographic areas provide a rationale for understanding the ecological and evolutionary trajectories of R. toxicus. PMID:27219107

Emergence of a New Population of Rathayibacter toxicus: An Ecologically Complex, Geographically Isolated Bacterium.

PubMed

Arif, Mohammad; Busot, Grethel Y; Mann, Rachel; Rodoni, Brendan; Liu, Sanzhen; Stack, James P

2016-01-01

Rathayibacter toxicus is a gram-positive bacterium that infects the floral parts of several Poaceae species in Australia. Bacterial ooze is often produced on the surface of infected plants and bacterial galls are produced in place of seed. R. toxicus is a regulated plant pathogen in the U.S. yet reliable detection and diagnostic tools are lacking. To better understand this geographically-isolated plant pathogen, genetic variation as a function of geographic location, host species, and date of isolation was determined for isolates collected over a forty-year period. Discriminant analyses of recently collected and archived isolates using Multi-Locus Sequence Typing (MLST) and Inter-Simple Sequence Repeats (ISSR) identified three populations of R. toxicus; RT-I and RT-II from South Australia and RT-III from Western Australia. Population RT-I, detected in 2013 and 2014 from the Yorke Peninsula in South Australia, is a newly emerged population of R. toxicus not previously reported. Commonly used housekeeping genes failed to discriminate among the R. toxicus isolates. However, strategically selected and genome-dispersed MLST genes representing an array of cellular functions from chromosome replication, antibiotic resistance and biosynthetic pathways to bacterial acquired immunity were discriminative. Genetic variation among isolates within the RT-I population was less than the within-population variation for the previously reported RT-II and RT-III populations. The lower relative genetic variation within the RT-I population and its absence from sampling over the past 40 years suggest its recent emergence. RT-I was the dominant population on the Yorke Peninsula during the 2013-2014 sampling period perhaps indicating a competitive advantage over the previously detected RT-II population. The potential for introduction of this bacterial plant pathogen into new geographic areas provide a rationale for understanding the ecological and evolutionary trajectories of R. toxicus.

Preventive effects of car safety seat use on clinical outcomes in infants and young children with road traffic injuries: A 7-year observational study.

PubMed

Park, Gwan Jin; Ro, Young Sun; Shin, Sang Do; Song, Kyoung Jun; Hong, Ki Jeong; Jeong, Joo

2018-06-01

Road traffic injury (RTI) is one of the major mechanisms of injury leading to high disability and case-fatality in infants and children. Proper car safety seat use can reduce fatal outcomes in pediatric patients with RTI; however, the use rate is still low. This study aimed to measure the preventive effects of car safety seat use on clinical outcomes among infants and young children injured from RTI. A multicenter cross-sectional study was conducted using the Emergency Department-based Injury In-depth Surveillance (EDIIS) registry from 23 EDs between Jan 2010 and Dec 2016. All pediatric patients who were under 6 years of age and who sustained RTI in a vehicle with fewer than 10-seats were eligible. Primary and secondary endpoints were intracranial injury and mortality. We calculated the adjusted odds ratio (AOR) of the car safety seat for related outcomes adjusting for potential confounders. Among 5545 eligible patients, 1452 (26.2%) patients were in car safety seats at the time of the crash (12.5% in 2010 to 33.9% in 2016, p-for-trend <0.01), and 104 (1.9%) patients had intracranial injuries. The patients using car safety seats were less likely to have intracranial injuries compared with the patients not using car safety seats (0.8% vs. 2.2%, AOR: 0.31 (0.17-0.57)). However, there was no significant difference in mortality between the two groups (0.4% vs. 0.6%, AOR: 0.50 (0.20-1.25)). Use of the car safety seat has significant preventive effects on intracranial injury. Public health efforts to increase use of car safety seats for infants and young children are needed to reduce the burden of RTI. Copyright © 2018 Elsevier Ltd. All rights reserved.

Road traffic injuries in northern Laos: trends and risk factors of an underreported public health problem.

PubMed

Slesak, Günther; Inthalath, Saythong; Wilder-Smith, Annelies; Barennes, Hubert

2015-11-01

Road traffic injuries (RTI) have become a leading cause for admissions at Luang Namtha Provincial Hospital (LNPH) in rapidly developing northern Laos. Objectives were to investigate trends, risk factors and better estimates of RTI. Repeated annual surveys were conducted with structured questionnaires among all RTI patients at LNPH from 2007 to 2011. Hospital and police data were combined by capture-recapture method. The majority of 1074 patients were young [median 22 years (1-88)], male (68%), motorcyclists (76%), drove without licence (85%) and without insurance (95%). Most accidents occurred during evenings and Lao New Year. Serious motorbike injuries were associated with young age (1-15 years), male sex (OR 2.2, 95% CI 1.1-4.6) and drivers (OR 2.1, 95% CI 1.1-4.3); more serious head injuries with alcohol consumption (OR 2.5, 95% CI 1.7-3.7), male sex (OR 2.3, 95% CI 1.4-3.7) and no helmet use (OR 2.0, 95% CI 1.2-3.4). No helmet use was associated with young age, time period, pillion passengers (OR 2.7, 95% CI 1.6-4.7), alcohol (OR 1.9, 95% CI 1.2-2.8) and no driver license (OR 2.0; 95% CI 1.1-3.4). Main reasons not to wear helmets were not possessing one, and being pillion passenger. Capture-recapture analysis showed four times higher RTI estimates than officially reported. Mortality rate was 11.6/100.000 population (95% CI 5.1-18.1/100.000). RTI were substantially underestimated. Combining hospital with police data can provide better estimates in resource-limited settings. Preventive programmes and law enforcement have to target male drivers, alcohol, licensing and helmet use, especially among children and pillion passengers. Increased efforts are needed during evening time and special festivals. © 2015 John Wiley & Sons Ltd.

The discovery of student experiences using the Frayer model map as a Tier 2 intervention in secondary science

NASA Astrophysics Data System (ADS)

Miller, Cory D.

The purpose of this study was to discover the student experiences of using the Frayer model map as a Tier 2 intervention in science. As a response to the criticized discrepancy model and the mandates contained in NCLB and the IDEA, response to intervention (RtI) has been implemented in education to increase achievement for all students and to discover what students need further interventions. Based on Cronbach's (1957) aptitude X treatment interaction theory, RtI assumes that progress over time can be measured when interventions are applied. While RtI has been actively implemented in reading and math, it has not been implemented in science. Therefore, it was not known what the experiences of students are using the Frayer model map as a Tier 2 intervention to impact science achievement. The multiple case study used a qualitative methodology that included pre-intervention and post-intervention web-based surveys, field notes during observations, and student work that were collected during the course of the study. The population that was studied was seventh- and eighth-grade students considered at-risk and attend a Title I school in Florida. The sample of the studied population was purposively selected according to a set of criteria similar to Tier 2 selection in RtI. The research question was, "What are the experiences of middle grades students using the Frayer model map as an instructional intervention in science?" The answer to the research question was that the experiences of students using the Frayer model map as a Tier 2 intervention in secondary science can be described as participants perceived the Frayer model map as use as a tool to organize tasks and create meaning while they completed the work independently and with accuracy. Even though there were limitations to quantity of data, the research question was adequately answered. Overall, the study fills a gap in the literature related to RtI and science education.

National Longitudinal Study of the High School Class of 1972: A Summary of the Merged Findings from Analyses by RTI of the First Follow-Up and Preceding Data. RTI Concept Paper No. CP-22-75-07.

ERIC Educational Resources Information Center

Research Triangle Inst., Durham, NC. Center for Educational Research and Evaluation.

An overview of the National Longitudinal Study of the High School Class of 1972 (NLS) is provided. Section one describes the research design for the base-year and first through third followup surveys. Section two summarizes findings from data analyses of the first followup and base-year, completed before September 1975. The findings are presented…

Aircraft data summaries for the SURE intensives. Final report. [Sampling done August 1977 near Rockport, Indiana and Duncan Falls, Ohio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blumenthal, D.L.; Tommerdahl, J.B.; McDonald, J.A.

1981-09-01

As part of the EPRI sulfate regional experiment (SURE), Meteorology Research, Inc., (MRI) and Research Triangle Institute (RTI) conducted six air quality sampling programs in the eastern United States using instrumented aircraft. This volume includes the air quality and meteorological data obtained during the August 1977 Intensive when MRI sampled near the Rockport, Indiana, SURE Station and RTI sampled near the Duncan Falls, Ohio, SURE Station. Sampling data are presented for all measured parameters.

RTI v medical ethics: some questions arising from the recent decision of the Chief Information Commissioner under the RTI Act.

PubMed

Nair, M R Hariharan

2015-01-01

Medical ethics attaches the utmost priority to the confidentiality of medical records. Hence, the decision of the Chief Information Commissioner (CIC) rendered on April 10, 2015 in Case No: CIC/KY/A/2014/001348SA Ms Jyoti Jeena v. PIO, Institute of Human Behaviour & Allied Science (hereinafter referred to as Jyoti Jeena), that the wife-applicant is entitled to get copies of the medical records of her estranged husband has raised many eyebrows.

Wave Energy Prize - 1/20th Testing - RTI Wave Power

DOE Data Explorer

Scharmen, Wesley

2016-09-30

Data from the 1/20th scale testing data completed on the Wave Energy Prize for the RTI Wave Power team, including the 1/20th Test Plan, raw test data, video, photos, and data analysis results. The top level objective of the 1/20th scale device testing is to obtain the necessary measurements required for determining Average Climate Capture Width per Characteristic Capital Expenditure (ACE) and the Hydrodynamic Performance Quality (HPQ), key metrics for determining the Wave Energy Prize (WEP) winners.

Radiative Transfer Modeling in Proto-planetary Disks

NASA Astrophysics Data System (ADS)

Kasper, David; Jang-Condell, Hannah; Kloster, Dylan

2016-01-01

Young Stellar Objects (YSOs) are rich astronomical research environments. Planets form in circumstellar disks of gas and dust around YSOs. With ever increasing capabilities of the observational instruments designed to look at these proto-planetary disks, most notably GPI, SPHERE, and ALMA, more accurate interfaces must be made to connect modeling of the disks with observation. PaRTY (Parallel Radiative Transfer in YSOs) is a code developed previously to model the observable density and temperature structure of such a disk by self-consistently calculating the structure of the disk based on radiative transfer physics. We present upgrades we are implementing to the PaRTY code to improve its accuracy and flexibility. These upgrades include: creating a two-sided disk model, implementing a spherical coordinate system, and implementing wavelength-dependent opacities. These upgrades will address problems in the PaRTY code of infinite optical thickness, calculation under/over-resolution, and wavelength-independent photon penetration depths, respectively. The upgraded code will be used to better model disk perturbations resulting from planet formation.

Reverse transcriptase inhibitors as microbicides.

PubMed

Lewi, Paul; Heeres, Jan; Ariën, Kevin; Venkatraj, Muthusamy; Joossens, Jurgen; Van der Veken, Pieter; Augustyns, Koen; Vanham, Guido

2012-01-01

The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing antiretrovirals that target specific enzymes in the reproduction cycle of HIV, especially reverse transcriptase inhibitors (RTI). In this review we discuss the potential relevance of HIV-1 RTIs as microbicides, focusing in the nucleotide RTI tenofovir and six classes of nonnucleoside RTIs (including dapivirine, UC781, urea and thiourea PETTs, DABOs and a pyrimidinedione). Although tenofovir and dapivirine appear to be most advanced in clinical trials as potential microbicides, several issues remain unresolved, e.g., the importance of nonhuman primates as a "gatekeeper" for clinical trials, the emergence and spread of drug-resistant mutants, the combination of microbicides that target different phases of viral reproduction and the accessibility to microbicides in low-income countries. Thus, here we discuss the latest research on RTI as microbicides in the light of the continuing spread of the HIV pandemic from the point of view of medicinal chemistry, virological, and pharmaceutical studies.

Finite plate thickness effects on the Rayleigh-Taylor instability in elastic-plastic materials

NASA Astrophysics Data System (ADS)

Polavarapu, Rinosh; Banerjee, Arindam

2017-11-01

The majority of theoretical studies have tackled the Rayleigh-Taylor instability (RTI) problem in solids using an infinitely thick plate. Recent theoretical studies by Piriz et al. (PRE 95, 053108, 2017) have explored finite thickness effects. We seek to validate this recent theoretical estimate experimentally using our rotating wheel RTI experiment in an accelerated elastic-plastic material. The test section consists of a container filled with air and mayonnaise (a non-Newtonian emulsion) with an initial perturbation between two materials. The plate thickness effects are studied by varying the depth of the soft-solid. A set of experiments is run by employing different initial conditions with different container dimensions. Additionally, the effect of acceleration rate (driving pressure rise time) on the instability threshold with reference to the finite thickness will also be inspected. Furthermore, the experimental results are compared to the analytical strength models related to finite thickness effects on RTI. Authors acknowledge financial support from DOE-SSAA Grant # DE-NA0003195 and LANL subcontract #370333.

Is a Response to Intervention (RTI) Approach to Preschool Language and Early Literacy Instruction Needed?

PubMed Central

Greenwood, Charles R.; Carta, Judith J.; Atwater, Jane; Goldstein, Howard; Kaminski, Ruth; McConnell, Scott

2014-01-01

Preschool experience plays a role in children's development. However, for programs with language and early literacy goals, the question remains whether or not preschool instructional experiences are sufficiently effective to achieve these goals for all children. In a multisite study, we conducted a process-product description of preschool instruction and children's growth and outcomes in typical programs (i.e., Pre-Kindergarten, Title 1, Head Start, Tuition-Based) using a Response to Intervention (RTI) perspective. Results indicated that (a) students in their preschool year prior to kindergarten made small gains, but students starting the year in lower Tier 2 and 3 performance levels did not close initial skills gaps, (b) variations were noted by program types with varying socio-demographics and instructional processes, and (c) the quality of instruction (Tier 1) received by all was low with room for improvement. Implications for future research on the application of the RTI approach and potential benefits are discussed. PMID:24899769

Exploring the relationship between development and road traffic injuries: a case study from India.

PubMed

Garg, Nitin; Hyder, Adnan A

2006-10-01

Road traffic injuries (RTI) are a major cause of mortality and disability in the world. Only after significant losses have communities in developed nations taken necessary steps to prevent crashes and their consequences. Increase in road safety is related to increasing socio-economic development. We aim to study the trends in injury and death rates in a developing country, India, define sub-national variations, and analyse these trends in relation to economic and population growth. Public sector data from India were used to develop a standardized database on traffic injuries and indicator of economic development. The data were analysed using linear regression models to test the a priori hypothesis of a positive relationship between net domestic product (NDP), and injury and death rates from road crashes across states. The absolute burden of RTI in India has been consistently rising over the past three decades. The reported rates are lower than those estimated by global health agencies and may reflect under-reporting. Population-based rates provide a better assessment of the public health burden of RTI than vehicle-based rates. There is an inverted U-shaped relationship between NDP and injury and death rates. Even with the limited data, Kuznets phenomenon is evident for within-country level comparisons. India and other developing countries could learn from the experience of highly motorized nations to avoid the expected rise in RTI and deaths with economic development, by currently investing in road safety and prevention measures.

Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site*

PubMed Central

Dahal, Rejwi Acharya; Pramod, Akula Bala; Sharma, Babita; Krout, Danielle; Foster, James D.; Cha, Joo Hwan; Cao, Jianjing; Newman, Amy Hauck; Lever, John R.; Vaughan, Roxanne A.; Henry, L. Keith

2014-01-01

The dopamine transporter (DAT) functions as a key regulator of dopaminergic neurotransmission via re-uptake of synaptic dopamine (DA). Cocaine binding to DAT blocks this activity and elevates extracellular DA, leading to psychomotor stimulation and addiction, but the mechanisms by which cocaine interacts with DAT and inhibits transport remain incompletely understood. Here, we addressed these questions using computational and biochemical methodologies to localize the binding and adduction sites of the photoactivatable irreversible cocaine analog 3β-(p-chlorophenyl)tropane-2β-carboxylic acid, 4′-azido-3′-iodophenylethyl ester ([125I]RTI 82). Comparative modeling and small molecule docking indicated that the tropane pharmacophore of RTI 82 was positioned in the central DA active site with an orientation that juxtaposed the aryliodoazide group for cross-linking to rat DAT Phe-319. This prediction was verified by focused methionine substitution of residues flanking this site followed by cyanogen bromide mapping of the [125I]RTI 82-labeled mutants and by the substituted cysteine accessibility method protection analyses. These findings provide positive functional evidence linking tropane pharmacophore interaction with the core substrate-binding site and support a competitive mechanism for transport inhibition. This synergistic application of computational and biochemical methodologies overcomes many uncertainties inherent in other approaches and furnishes a schematic framework for elucidating the ligand-protein interactions of other classes of DA transport inhibitors. PMID:25179220

Human resources for the control of road traffic injury.

PubMed

Mock, Charles; Kobusingye, Olive; Anh, Le Vu; Afukaar, Francis; Arreola-Risa, Carlos

2005-04-01

The definition of the ideal numbers and distribution of human resources required for control of road traffic injury (RTI) is not as advanced as for other health problems. We can nonetheless identify functions that need to be addressed across the spectrum of injury control: surveillance; road safety (including infrastructure, vehicle design, and behaviour); and trauma care. Many low-cost strategies to improve these functions in low- or middle-income countries can be identified. For all these strategies, there is need for adequate institutional capacity, including funding, legal authority, and human resources. Several categories of human resources need to be developed: epidemiologists who can handle injury data, design surveillance systems, and undertake research; engineers and planners versed in safety aspects of road design, traffic flow, urban planning, and vehicle design; police and lawyers who understand the health impact of traffic law; clinicians who can develop cost-effective improvements in the entire system of trauma treatment; media experts to undertake effective behaviour change and social marketing; and economists to assist with cost-effectiveness evaluations. RTI control can be strengthened by enhancing such training in these disciplines, as well as encouraging retention of those who have the needed skills. Mechanisms to enhance collaboration between these different fields need to be promoted. Finally, the burden of RTI is borne disproportionately by the poor; in addition to technical issues, more profound equity issues must be addressed. This mandates that people from all professional backgrounds who work for RTI control should develop skills in advocacy and politics.

Human resources for the control of road traffic injury.

PubMed Central

Mock, Charles; Kobusingye, Olive; Anh, Le Vu; Afukaar, Francis; Arreola-Risa, Carlos

2005-01-01

The definition of the ideal numbers and distribution of human resources required for control of road traffic injury (RTI) is not as advanced as for other health problems. We can nonetheless identify functions that need to be addressed across the spectrum of injury control: surveillance; road safety (including infrastructure, vehicle design, and behaviour); and trauma care. Many low-cost strategies to improve these functions in low- or middle-income countries can be identified. For all these strategies, there is need for adequate institutional capacity, including funding, legal authority, and human resources. Several categories of human resources need to be developed: epidemiologists who can handle injury data, design surveillance systems, and undertake research; engineers and planners versed in safety aspects of road design, traffic flow, urban planning, and vehicle design; police and lawyers who understand the health impact of traffic law; clinicians who can develop cost-effective improvements in the entire system of trauma treatment; media experts to undertake effective behaviour change and social marketing; and economists to assist with cost-effectiveness evaluations. RTI control can be strengthened by enhancing such training in these disciplines, as well as encouraging retention of those who have the needed skills. Mechanisms to enhance collaboration between these different fields need to be promoted. Finally, the burden of RTI is borne disproportionately by the poor; in addition to technical issues, more profound equity issues must be addressed. This mandates that people from all professional backgrounds who work for RTI control should develop skills in advocacy and politics. PMID:15868021

Aircraft data summaries for the SURE intensives. Final report. [Data obtained during January/February 1978 near Duncan Falls, Ohio and Lewisburg, Virginia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keifer, W.S.; Blumenthal, D.L.; Tommerdahl, J.B.

1981-09-01

As part of the EPRI sulfate regional experiment (SURE), Meteorology Research, Inc., (MRI) and Research Triangle Institute (RTI) conducted six air quality sampling programs in the eastern United States using instrumented aircraft. This volume includes the air quality and meteorological data obtained during the January/February 1978 Intensive when MRI sampled near the Duncan Falls, Ohio, SURE Station and RTI sampled near the Lewisburg, Virginia, SURE Station. Sampling data are presented for all measured parameters.

Aircraft data summaries for the SURE intensives. Final report. [Sampling done October, 1978 near Duncan Falls, Ohio and Giles County, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keifer, W.S.; Blumenthal, D.L.; Tommerdahl, J.B.

1981-09-01

As part of the EPRI sulfate regional experiment (SURE), Meteorology Research, Inc., (MRI) and Research Triangle Institute (RTI) conducted six air quality sampling programs in the eastern United States using instrumented aircraft. This volume includes the air quality and meteorological data obtained during the October 1978 intensive when MRI sampled near the Giles County, Tennessee, SURE Station and RTI sampled near the Duncan Falls, Ohio, SURE Station. Sampling data are presented for all measured parameters.

Impact of the 2011 Libyan conflict on road traffic injuries in Benghazi, Libya.

PubMed

Bodalal, Zuhir; Bendardaf, Riyad; Ambarek, Mohammed; Nagelkerke, Nico

2015-01-01

Road traffic injuries (RTIs) are a major public health concern in Libya. In the light of the armed conflict in Libya that broke out on February 2011 and the subsequent instability, the rate and pattern of RTIs was studied. RTI patient data were gathered from Al-Jalaa hospital, the main trauma center in Benghazi, from 2010 to 2011. Various parameters [i.e. age, gender, nationality, method of entry, receiving department, intensive care unit (ICU) admission, duration of stay, method of discharge, and fatalities] were compared with data from the previous year (2010), and statistical analyses were performed (t-test, chi-square, and Poisson regression). During the conflict period, 15.8% (n=2,221) of hospital admissions were RTIs, that is, a rate of 6.08 RTI cases per day, levels not seen for 5 years (t=-5.719, p<0.001). The presence of armed conflict was found to have caused a significant 28% decrease in the trend of RTIs over the previous 10 years (B=-0.327, CI=-0.38--0.28, p<0.001). February and March, the peak period of active combat in Benghazi, witnessed the lowest number of RTIs during the conflict period. The average age of an RTI decreased to 28.35±16.3 years (t=-7.257, p<0.001) with significantly more males (84.1%, n=1,755) being affected (χ(2)=4.595, p=0.032, df=1). There was an increase in the proportion of younger aged patients (from 0 to 29 years) (χ(2)=29.874, p<0.001, df=8). More patients required admission to the ICU (χ(2)=36.808, p<0.001, df=8), and the mortality of an RTI increased to 5.2% (n=116) (χ(2)=48.882, p<0.001, df=6). There were fewer RTIs during the conflict period; however, those that occurred had higher morbidity and mortality. The profile of an RTI victims also changed to an increased prominence of young males and motorcyclists. Further research is required to propose and analyze possible interventions.

Impact of the 2011 Libyan conflict on road traffic injuries in Benghazi, Libya

PubMed Central

Bodalal, Zuhir; Bendardaf, Riyad; Ambarek, Mohammed; Nagelkerke, Nico

2015-01-01

Background Road traffic injuries (RTIs) are a major public health concern in Libya. In the light of the armed conflict in Libya that broke out on February 2011 and the subsequent instability, the rate and pattern of RTIs was studied. Methods RTI patient data were gathered from Al-Jalaa hospital, the main trauma center in Benghazi, from 2010 to 2011. Various parameters [i.e. age, gender, nationality, method of entry, receiving department, intensive care unit (ICU) admission, duration of stay, method of discharge, and fatalities] were compared with data from the previous year (2010), and statistical analyses were performed (t-test, chi-square, and Poisson regression). Results During the conflict period, 15.8% (n=2,221) of hospital admissions were RTIs, that is, a rate of 6.08 RTI cases per day, levels not seen for 5 years (t=−5.719, p<0.001). The presence of armed conflict was found to have caused a significant 28% decrease in the trend of RTIs over the previous 10 years (B=−0.327, CI=−0.38–−0.28, p<0.001). February and March, the peak period of active combat in Benghazi, witnessed the lowest number of RTIs during the conflict period. The average age of an RTI decreased to 28.35±16.3 years (t=−7.257, p<0.001) with significantly more males (84.1%, n=1,755) being affected (χ2=4.595, p=0.032, df=1). There was an increase in the proportion of younger aged patients (from 0 to 29 years) (χ2=29.874, p<0.001, df=8). More patients required admission to the ICU (χ2=36.808, p<0.001, df=8), and the mortality of an RTI increased to 5.2% (n=116) (χ2=48.882, p<0.001, df=6). Conclusion There were fewer RTIs during the conflict period; however, those that occurred had higher morbidity and mortality. The profile of an RTI victims also changed to an increased prominence of young males and motorcyclists. Further research is required to propose and analyze possible interventions. PMID:25673038

Reproductive Tract Infections and Treatment Seeking Behavior among Married Adolescent Women 15-19 Years in India.

PubMed

Prusty, Ranjan Kumar; Unisa, Sayeed

2013-01-01

India is home to the highest number of adolescents in the world. Adolescents in India suffer from lack of knowledge and empowerment to make informed sexual and reproductive health decisions. This paper analyses the prevalence of reproductive tract infections and sexually transmitted infections (RTI/STI) and treatment seeking behavior among married adolescent women in India aged 15-19 years. Data from the District Level Household Survey (DLHS, 2007-08) of India were used. The prevalence of RTIs symptoms and treatment seeking behavior among women by different socio-demographic characteristics was analyzed. Factor analysis was utilized to create an index using information about 11 symptoms of RTI/STI collected in the survey. Linear and binary logistic regressions were used to know the association between infections and treatment seeking behavior with socio-demographic factors. About 15 percent of adolescent women reported having any symptoms of RTI/STI. The main symptoms reported were low backache, pain in the lower abdomen, pain during intercourse and itching or irritation around the vulvar region. Factor analysis showed the concentration of diseases in three clusters - infection in around the vulva, other reproductive infection and abnormal discharge; and intercourse related problems. Major predictors of both symptoms of reproductive infections and treatment seeking behavior from multivariate analysis are age, education, wealth, region and awareness about RTI/STI. Knowledge and treatment seeking behavior is poor among adolescent women in India. There is need for programmatic and policy emphasis on increasing knowledge and awareness through family life education including in educational curriculum at school level.

Spatial analysis of the regional variation of reproductive tract infections and spousal migration correlates in Nepal.

PubMed

Johnson, Derek C; Lhaki, Pema; Buehler Cherry, Charlotte; Kempf, Mirjam-Colette; Chamot, Eric; Vermund, Sten H; Shrestha, Sadeep

2017-05-30

Nepal has a diverse geographic landscape that could potentially create clustered subpopulations with regional socio-cultures that could result in differential health outcomes. With an alarming rise in married male populations migrating for work, it is possible that these migrants are engaged in risky sexual behaviour, putting their wives at risk for infectious disease outcomes, including reproductive tract infections (RTI), when they return home. The prevalence of male migration varies by geographic region in Nepal and this variation could potentially contribute to different RTI rates. Using a cross-sectional dataset (the 2011 Nepal Demographic and Health Survey) including 9607 married women, we investigated geospatial and socio-cultural factors associated with the symptoms of RTIs with a focus on the husbands' migration status. Choropleth maps were created to illustrate areas with high percentages of RTIs that correlated with migration patterns. Overall, 31.9% of the husbands were migrating for work. After adjusting for wealth, contraception use, age at first marriage, urban/rural status and husband's education, women whose husbands had been absent for a year or more in Nepal's Mid-West region (OR 1.93 95%, CI 1.02-3.67) or Far-West region (OR 2.89 95%, CI 1.24-6.73) were more likely to report RTI-like symptoms than others. Our results suggest a potential association between husbands' migration status and Nepali women reporting RTI symptoms by geographic regions. However, further research is needed to put this outcome on a stronger footing with respect to this under-studied population, specifically in the context of geographical variation.

Response to Instruction in Preschool: Results of Two Randomized Studies with Children At Significant Risk of Reading Difficulties

PubMed Central

Lonigan, Christopher J.; Phillips, Beth M.

2015-01-01

Although response-to-instruction (RTI) approaches have received increased attention, few studies have evaluated the potential impacts of RTI approaches with preschool populations. This manuscript presents results of two studies examining impacts of Tier II instruction with preschool children. Participating children were identified as substantially delayed in the acquisition of early literacy skills despite exposure to high-quality, evidence-based classroom instruction. Study 1 included 93 children (M age = 58.2 months; SD = 3.62) attending 12 Title I preschools. Study 2 included 184 children (M age = 58.2 months; SD = 3.38) attending 19 Title I preschools. The majority of children were Black/African American, and about 60% were male. In both studies, eligible children were randomized to receive either 11 weeks of need-aligned, small-group instruction or just Tier I. Tier II instruction in Study 1 included variations of activities for code- and language-focused domains with prior evidence of efficacy in non-RTI contexts. Tier II instruction in Study 2 included instructional activities narrower in scope, more intensive, and delivered to smaller groups of children. Impacts of Tier II instruction in Study 1 were minimal; however, there were significant and moderate-to-large impacts in Study 2. These results identify effective Tier II instruction but indicate that the context in which children are identified may alter the nature of Tier II instruction that is required. Children identified as eligible for Tier II in an RTI framework likely require more intensive and more narrowly focused instruction than do children at general risk of later academic difficulties. PMID:26869730

The relation of linguistic awareness and vocabulary to word reading and spelling for first grade students participating in Response to Intervention

PubMed Central

Kim, Young-Suk; Apel, Kenn; Otaiba, Stephanie Al

2013-01-01

Purpose We examined the relations of phonological, morphological, and orthographic awareness and vocabulary to word reading and spelling for first grade children who were receiving differentiated instruction in a Response to Intervention (RTI) model of instruction (N = 304). Method First grade children were assessed on their phonological, morphological, and orthographic awareness, expressive vocabulary, word reading, and spelling. Year-end word reading and spelling were outcome variables while phonological, morphological, and orthographic awareness, expressive vocabulary, and RTI status (Tiers 1, 2, & 3) were predictor variables assessed in the middle of the school year. Results The three linguistic awareness skills were unique predictors of word reading and phonological and orthographic awareness were unique predictors of spelling. The contributions these linguistic awareness skills and vocabulary made to word reading and spelling did not differ by children's RTI tier status. Conclusion These results, in conjunction with previous studies, suggest that even beginning readers and spellers draw on multiple linguistic awareness skills for their word reading and spelling regardless of their level of literacy skills. Educational implications are discussed. PMID:23833281

The relation of linguistic awareness and vocabulary to word reading and spelling for first-grade students participating in response to intervention.

PubMed

Kim, Young-Suk; Apel, Kenn; Al Otaiba, Stephanie

2013-10-01

The relations of phonological, orthographic, and morphological awareness and vocabulary to word reading and spelling were examined for 304 first-grade children who were receiving differentiated instruction in a Response to Intervention (RtI) model of instruction. First-grade children were assessed on their phonological, orthographic, and morphological awareness; expressive vocabulary; word reading; and spelling. Year-end word reading and spelling were outcome variables, and phonological, orthographic, and morphological awareness; expressive vocabulary; and RtI status (Tiers 1, 2, & 3) were predictor variables. The 3 linguistic awareness skills were unique predictors of word reading, and phonological and orthographic awareness were unique predictors of spelling. The contributions that these linguistic awareness skills and vocabulary made to word reading and spelling did not differ by children's RtI tier status. These results, in conjunction with previous studies, suggest that even beginning readers and spellers draw on multiple linguistic awareness skills for their word reading and spelling regardless of their level of literacy abilities. Educational implications are discussed.

Can pay-for-performance to primary care providers stimulate appropriate use of antibiotics?

PubMed

Ellegård, Lina Maria; Dietrichson, Jens; Anell, Anders

2018-01-01

Antibiotic resistance is a major threat to public health worldwide. As the healthcare sector's use of antibiotics is an important contributor to the development of resistance, it is crucial that physicians only prescribe antibiotics when needed and that they choose narrow-spectrum antibiotics, which act on fewer bacteria types, when possible. Inappropriate use of antibiotics is nonetheless widespread, not least for respiratory tract infections (RTI), a common reason for antibiotics prescriptions. We examine if pay-for-performance (P4P) presents a way to influence primary care physicians' choice of antibiotics. During 2006-2013, 8 Swedish healthcare authorities adopted P4P to make physicians select narrow-spectrum antibiotics more often in the treatment of children with RTI. Exploiting register data on all purchases of RTI antibiotics in a difference-in-differences analysis, we find that P4P significantly increased the share of narrow-spectrum antibiotics. There are no signs that physicians gamed the system by issuing more prescriptions overall. © 2017 The Authors Health Economics Published by John Wiley & Sons Ltd.

Predicting First Grade Reading Performance from Kindergarten Response to Tier 1 Instruction

PubMed Central

Al Otaiba, Stephanie; Folsom, Jessica S.; Schatschneider, Christopher; Wanzek, Jeanne; Greulich, Luana; Meadows, Jane; Li, Zhi; Connor, Carol M

2010-01-01

Many schools are beginning to implement multi-tier response to intervention (RTI) models for the prevention of reading difficulties and to assist in the identification of students with learning disabilities (LD). The present study was part of our larger ongoing longitudinal RTI investigation within the Florida Learning Disabilities Center grant. This study used a longitudinal correlational design, conducted in 7 ethnically and socio-economically diverse schools. We observed reading instruction in 20 classrooms, examined response rates to kindergarten Tier 1 instruction, and predicted students’ first grade reading performance based upon kindergarten growth and end of year reading performance (n = 203). Teachers followed an explicit core reading program and overall, classroom instruction was rated as effective. Results indicate that controlling for students’ end of kindergarten reading, their growth across kindergarten on a variety of language and literacy measures suppressed predictions of first grade performance. Specifically, the steeper the students’ trajectory to a satisfactory outcome, the less likely they were to demonstrate good performance in first grade. Implications for future research and RTI implementation are discussed. PMID:21857718

Direct and indirect costs of nonfatal road traffic injuries in Iran: A population-based study.

PubMed

Karimi, Hasti; Soleyman-Jahi, Saeed; Hafezi-Nejad, Nima; Rahimi-Movaghar, Afarin; Amin-Esmaeili, Masoumeh; Sharifi, Vandad; Hajebi, Ahmad; Saadat, Soheil; Akbari Sari, Ali; Rahimi-Movaghar, Vafa

2017-05-19

The objective of this study was to assess the incidence rate as well as direct and indirect costs of nonfatal road traffic injuries (RTIs) in Iran in 2011. Data from the 2011 national household survey were used. In this survey, data on demographics, history, and costs of injury were obtained in 2 steps: first, direct face-to-face interview and second, telephone calls. We estimated the incidence rate of nonfatal RTIs in this year. The direct costs included medical care as well as nonmedical costs paid by the patient or insurance services. The indirect costs were estimated by considering the cost of absence from work or education. We also used logistic regression analyses to investigate risk factors of nonfatal RTIs. We found 76 nonfatal RTI cases (0.96%) out of 7,886 whole reference study cases. These 76 injured patients had a history of RTI in the preceding 3 months. The annual incidence of RTIs was estimated at 3.84%. The mean age of RTI cases was 28.5 ± 10.6 and 88.16% of them were male. Male gender was a major risk factor (odds ratio [OR] = 9.64, 95% confidence interval [CI], 4.79-19.41) and marriage was a protective factor (OR = 0.44, 95% CI, 0.28-0.70) for RTI. The medians of direct, indirect, and total costs were US$214, US$163, and US$387, respectively. The total cost of nonfatal RTIs in Iran was estimated at 1.29% of the gross domestic product (GDP) in 2011. In Iran, nonfatal RTIs imposed a total cost of almost US$7 billion to the country for one year. Extension and more serious implementation of preventive measurements seem necessary to decrease this notable burden of RTIs.

Reproductive Tract Infections and Treatment Seeking Behavior among Married Adolescent Women 15-19 Years in India

PubMed Central

Prusty, Ranjan Kumar; Unisa, Sayeed

2013-01-01

Background: India is home to the highest number of adolescents in the world. Adolescents in India suffer from lack of knowledge and empowerment to make informed sexual and reproductive health decisions. This paper analyses the prevalence of reproductive tract infections and sexually transmitted infections (RTI/STI) and treatment seeking behavior among married adolescent women in India aged 15-19 years. Methods: Data from the District Level Household Survey (DLHS, 2007-08) of India were used. The prevalence of RTIs symptoms and treatment seeking behavior among women by different socio-demographic characteristics was analyzed. Factor analysis was utilized to create an index using information about 11 symptoms of RTI/STI collected in the survey. Linear and binary logistic regressions were used to know the association between infections and treatment seeking behavior with socio-demographic factors. Results: About 15 percent of adolescent women reported having any symptoms of RTI/STI. The main symptoms reported were low backache, pain in the lower abdomen, pain during intercourse and itching or irritation around the vulvar region. Factor analysis showed the concentration of diseases in three clusters - infection in around the vulva, other reproductive infection and abnormal discharge; and intercourse related problems. Major predictors of both symptoms of reproductive infections and treatment seeking behavior from multivariate analysis are age, education, wealth, region and awareness about RTI/STI. Conclusions and Public Health Implications: Knowledge and treatment seeking behavior is poor among adolescent women in India. There is need for programmatic and policy emphasis on increasing knowledge and awareness through family life education including in educational curriculum at school level. PMID:27621963

Household environment and behavioral determinants of respiratory tract infection in infants and young children in northern Bangladesh.

PubMed

Nasanen-Gilmore, S Pieta K; Saha, Subir; Rasul, Izaz; Rousham, Emily K

2015-01-01

Respiratory tract infections (RTI) are one of the leading causes of under-five mortality in Bangladesh. Solid biomass fuels are the main source of domestic fuel used for cooking across Bangladesh, leading to smoke and pollution exposure in the home. This article aims to identify risk factors for RTI among children aged under five years in Bangladesh with a particular focus on the household environment, fuel use, and cooking practices. A cross-sectional household-health survey was carried out in 321 households in northern Bangladesh. The survey included care-giver interviews on cooking practices, child health, and household behaviors during cooking. Health status of the youngest child (under five years) from each household was recorded through maternal interviews, medical diagnosis, and assessment of biomarkers (C-reactive protein (CRP), hemoglobin) from finger-prick blood samples. Anthropometric status (weight, height) was recorded. Children who spent ≥30 minutes/day within 5 feet of the stove during cooking had a significantly increased risk of moderate/severe RTI compared with children spending <30 minutes/day close to the stove (OR = 2.15, 95%CI: 1.20-3.86, P = 0.01), independent of socio-economic status (SES), biomass fuel type (wood, dung, plant-derived, compressed rice husks), child age, anthropometric status, CRP and hemoglobin. In environments with a heavy reliance on solid biomass fuels, the amount of time a child spends near the stove during cooking may be an important risk for RTI. These novel findings from Bangladesh warrant further investigation of mother-infant behaviors during cooking in relation to child health, to ascertain whether the association is likely to be causal. © 2015 Wiley Periodicals, Inc.

Characteristic Evaluation of Synchronous Motors Using an Universal Drive System with a Real-Time Interface

NASA Astrophysics Data System (ADS)

Amano, Yoko; Ogasawara, Satoshi

In this paper, a new universal drive system of synchronous motors used Real-Time Interface (RTI) performs characteristic evaluation of Synchronous Reluctance (SynR) motors and Surface Permanent Magnet (SPM) synchronous motors. The RTI connects directly a simulation model with experimental equipment, and makes it possible to use the simulation model for an experiment. The RTI is very effective in the early detection of an actual problem and examination of solution technique. Moreover, it concentrates on examination of control algorithm, and efficient research and development are enabled. A measuring system of synchronous motors is built by the universal drive system. The examination of various synchronous motors is possible for the measurement system using the same control algorithm. Characteristic evaluation of a SynR motor and a SPM synchronous motor that are the same gap length and stator was performed using the measuring system. The measurement result shows experimentally that motor loss of the SynR motor is smaller rather than the SPM synchronous motor, at the time of high speed and low load operation. For example, the SynR motor is suitable to hybrid cars with the comparatively long time of low load and high-speed operation.

Temperature Evolution of a 1 MA Triple-Nozzle Gas-Puff Z-Pinch

NASA Astrophysics Data System (ADS)

de Grouchy, Philip; Banasek, Jacob; Engelbrecht, Joey; Qi, Niansheng; Atoyan, Levon; Byvank, Tom; Cahill, Adam; Moore, Hannah; Potter, William; Ransohoff, Lauren; Hammer, David; Kusse, Bruce; Laboratory of Plasma Studies Team

2015-11-01

Mitigation of the Rayleigh-Taylor instability (RTI) plays a critical role in optimizing x-ray output at high-energy ~ 13 keV using the triple-nozzle Krypton gas-puff at Sandia National Laboratory. RTI mitigation by gas-puff density profiling using a triple-nozzle gas-puff valve has recently been recently demonstrated on the COBRA 1MA z-pinch at Cornell University. In support of this work we investigate the role of shell cooling in the growth of RTI during gas-puff implosions. Temperature measurements within the imploding plasma shell are recorded using a 527 nm, 10 GW Thomson scattering diagnostic for Neon, Argon and Krypton puffs. The mass-density profile is held constant at 22 microgram per centimeter for all three puffs and the temperature evolution of the imploding material is recorded. In the case of Argon puffs we find that the shell ion and electron effective temperatures remain in equilibrium at around 1keV for the majority of the implosion phase. In contrast scattered spectra from Krypton are dominated by of order 10 keV effective ion temperatures. Supported by the NNSA Stewardship Sciences Academic Programs.

Re-entrant relaxor behavior of Ba{sub 5}RTi{sub 3}Nb{sub 7}O{sub 30} (R = La, Nd, Sm) tungsten bronze ceramics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Kun; Li Zhu, Xiao; Qiang Liu, Xiao

2013-03-18

Ba{sub 5}RTi{sub 3}Nb{sub 7}O{sub 30} (R = La, Nd, Sm) tungsten bronze ceramics were prepared, and the dielectric and ferroelectric properties were investigated over a broad temperature range. The relaxor nature was determined for all compositions in their permittivity curves, and a second anomaly of the dielectric loss (tan {delta}) was observed around 250 K in Ba{sub 5}NdTi{sub 3}Nb{sub 7}O{sub 30} and around 275 K in Ba{sub 5}SmTi{sub 3}Nb{sub 7}O{sub 30}. Both the maximum and remanent polarization tended to decrease and vanish at low temperatures in the ferroelectric phase for all compositions, which was referred to as the low temperaturemore » re-entrant relaxor behavior. The remanent polarization increased with decreasing temperature first and then reached the maximum value at the re-entrant temperature (T{sub r}). For Ba{sub 5}RTi{sub 3}Nb{sub 7}O{sub 30} (R = La, Nd, Sm), T{sub r} decreased with the radius of R{sup 3+} cations and the applied field amplitude.« less

Research on Collaborative Technology in Distributed Virtual Reality System

NASA Astrophysics Data System (ADS)

Lei, ZhenJiang; Huang, JiJie; Li, Zhao; Wang, Lei; Cui, JiSheng; Tang, Zhi

2018-01-01

Distributed virtual reality technology applied to the joint training simulation needs the CSCW (Computer Supported Cooperative Work) terminal multicast technology to display and the HLA (high-level architecture) technology to ensure the temporal and spatial consistency of the simulation, in order to achieve collaborative display and collaborative computing. In this paper, the CSCW’s terminal multicast technology has been used to modify and expand the implementation framework of HLA. During the simulation initialization period, this paper has used the HLA statement and object management service interface to establish and manage the CSCW network topology, and used the HLA data filtering mechanism for each federal member to establish the corresponding Mesh tree. During the simulation running period, this paper has added a new thread for the RTI and the CSCW real-time multicast interactive technology into the RTI, so that the RTI can also use the window message mechanism to notify the application update the display screen. Through many applications of submerged simulation training in substation under the operation of large power grid, it is shown that this paper has achieved satisfactory training effect on the collaborative technology used in distributed virtual reality simulation.

Structural and magnetic properties of RTiNO{sub 2} (R=Ce, Pr, Nd) perovskite nitride oxides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Porter, Spencer H.; Huang, Zhenguo, E-mail: zhenguo@uow.edu.au; Cheng, Zhenxiang

2015-03-15

Neutron powder diffraction indicates that CeTiNO{sub 2} and PrTiNO{sub 2} crystallize with orthorhombic Pnma symmetry (Ce: a=5.5580(5), b=7.8369(7), and c=5.5830(4) Å; Pr: a=5.5468(5), b=7.8142(5), and c=5.5514(5) Å) as a result of a{sup –}b{sup +}a{sup –} tilting of the titanium-centered octahedra. Careful examination of the NPD data, confirms the absence of long range anion order in both compounds, while apparent superstructure reflections seen in electron diffraction patterns provide evidence for short range anion order. Inverse magnetic susceptibility plots reveal that the RTiNO{sub 2} (R=Ce, Pr, Nd) compounds are paramagnetic with Weiss constants that vary from −28 to −42 K. Effective magneticmore » moments for RTiNO{sub 2} (R=Ce, Pr, Nd) are 2.43 μ{sub B}, 3.63 μ{sub B}, and 3.47 μ{sub B}, respectively, in line with values expected for free rare-earth ions. Deviations from Curie–Weiss behavior that occur below 150 K for CeTiNO{sub 2} and below 30 K for NdTiNO{sub 2} are driven by magnetic anisotropy, spin–orbit coupling, and crystal field effects. - Graphical abstract: The structure and magnetism of the oxide nitride perovskites RTiNO{sub 2} (R=Ce, Pr, Nd) have been explored. The average symmetry is shown to be Pnma with a random distribution of oxide and nitride ions and a{sup −}b{sup +}a{sup −} tilting of the titanium-centered octahedra, but electron diffraction shows evidence for short range anion order. All three compounds are paramagnetic but deviations from the Curie Weiss law are seen below 150 K for R=Ce and below 30 K for R=Nd. - Highlights: • The oxide nitride perovskites RTiNO{sub 2} (R=Ce, Pr) have been prepared and their structures determined. • Diffraction measurements indicate short range cis-order of O and N, but no long range order. • Compounds are paramagnetic with Weiss constants that vary from −28 to −42 K. • CeTiO{sub 2}N and NdTiO{sub 2}N deviate from Curie–Weiss behavior below 150 and 30 K, respectively.« less

Immune development and performance characteristics of Romney sheep selected for either resistance or resilience to gastrointestinal nematodes.

PubMed

Greer, A W; McKenzie, J L; McAnulty, R W; Huntley, J F; McNeilly, T N

2018-01-30

Immunological and performance characteristics were explored in Romney sheep from lines selected for either resistance or resilience to parasite infection. At a mean 78 days-of-age, twin lambs from a line selected for resistance (RT) and lambs from a line selected for resilience (RL) were infected with the intestinal nematode Trichostrongylus colubriformis for 100 days (I) while their twin remained as an uninfected control (C). Compared with RL, RT animals had lower levels of circulating CD4 + T-cells (P = 0.003) but a greater proportion of these were activated (CD4 + CD25 + ) in response to infection (P = 0.007). Differences between the lines in humoral immune responses to nematode infection varied with higher levels of T. colubriformis specific immunoglobulin (Ig) E in RT-I than RL-I (P = 0.002) but similar levels of both IgG (P = 0.926) and IgA (P = 0.321) responses. Temporal differences in the immune response also existed between the lines with RT-I animals displaying an earlier peak and more rapid reduction in FEC and an earlier peak in T. colubriformis specific IgA. In addition, compared with their RT-C and RL-C counterparts, infection caused a 22% reduction in feed intake from day 56 (P = 0.001) with total feed intake reduced by 15% and 9% for RT-I and RL-I, respectively. Cumulative liveweight gain was greatest for RL animals (P = 0.026) and relative to RT-C and RL-C was reduced by 5.8 kg and 4.9 kg for RT-I and RL-I, respectively. Overall, the selection lines appear to have differences in immunological characteristics that are both dependent on, and independent of parasite infection. Further, the difference in growth in the uninfected animals coupled with the similar cost of infection suggests the lower liveweight gain of RT-I compared with RL-I may be due to inherent differences between the lines in their growth potential, rather than a greater cost of infection in animals selected for resistance. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

Diffusion in Brain Extracellular Space

PubMed Central

Syková, Eva; Nicholson, Charles

2009-01-01

Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules in the brain. Deviations from the equation reveal loss of molecules across the blood-brain barrier, through cellular uptake, binding or other mechanisms. Early diffusion measurements used radiolabeled sucrose and other tracers. Presently, the real-time iontophoresis (RTI) method is employed for small ions and the integrative optical imaging (IOI) method for fluorescent macromolecules, including dextrans or proteins. Theoretical models and simulations of the ECS have explored the influence of ECS geometry, effects of dead-space microdomains, extracellular matrix and interaction of macromolecules with ECS channels. Extensive experimental studies with the RTI method employing the cation tetramethylammonium (TMA) in normal brain tissue show that the volume fraction of the ECS typically is about 20% and the tortuosity about 1.6 (i.e. free diffusion coefficient of TMA is reduced by 2.6), although there are regional variations. These parameters change during development and aging. Diffusion properties have been characterized in several interventions, including brain stimulation, osmotic challenge and knockout of extracellular matrix components. Measurements have also been made during ischemia, in models of Alzheimer's and Parkinson's diseases and in human gliomas. Overall, these studies improve our conception of ECS structure and the roles of glia and extracellular matrix in modulating the ECS microenvironment. Knowledge of ECS diffusion properties are valuable in contexts ranging from understanding extrasynaptic volume transmission to the development of paradigms for drug delivery to the brain. PMID:18923183

Harmonic growth of spherical Rayleigh-Taylor instability in weakly nonlinear regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Wanhai; LHD, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190; Chen, Yulian

Harmonic growth in classical Rayleigh-Taylor instability (RTI) on a spherical interface is analytically investigated using the method of the parameter expansion up to the third order. Our results show that the amplitudes of the first four harmonics will recover those in planar RTI as the interface radius tends to infinity compared against the initial perturbation wavelength. The initial radius dramatically influences the harmonic development. The appearance of the second-order feedback to the initial unperturbed interface (i.e., the zeroth harmonic) makes the interface move towards the spherical center. For these four harmonics, the smaller the initial radius is, the faster theymore » grow.« less

Observation of Rayleigh-Taylor-instability evolution in a plasma with magnetic and viscous effects

DOE PAGES

Adams, Colin S.; Moser, Auna L.; Hsu, Scott C.

2015-11-06

We present time-resolved observations of Rayleigh-Taylor-instability (RTI) evolution at the interface between an unmagnetized plasma jet colliding with a stagnated, magnetized plasma. The observed instability growth time (~10μs) is consistent with the estimated linear RTI growth rate calculated using experimentally inferred values of density (~10 14cm–3) and deceleration (~10 9 m/s 2). The observed mode wavelength (≳1 cm) nearly doubles within a linear growth time. Furthermore, theoretical estimates of magnetic and viscous stabilization and idealized magnetohydrodynamic simulations including a physical viscosity model both suggest that the observed instability evolution is subject to magnetic and/or viscous effects.

Potential Flow Model for Compressible Stratified Rayleigh-Taylor Instability

NASA Astrophysics Data System (ADS)

Rydquist, Grant; Reckinger, Scott; Owkes, Mark; Wieland, Scott

2017-11-01

The Rayleigh-Taylor Instability (RTI) is an instability that occurs when a heavy fluid lies on top of a lighter fluid in a gravitational field, or a gravity-like acceleration. It occurs in many fluid flows of a highly compressive nature. In this study potential flow analysis (PFA) is used to model the early stages of RTI growth for compressible fluids. In the localized region near the bubble tip, the effects of vorticity are negligible, so PFA is applicable, as opposed to later stages where the induced velocity due to vortices generated from the growth of the instability dominate the flow. The incompressible PFA is extended for compressibility effects by applying the growth rate and the associated perturbation spatial decay from compressible linear stability theory. The PFA model predicts theoretical values for a bubble terminal velocity for single-mode compressible RTI, dependent upon the Atwood (A) and Mach (M) numbers, which is a parameter that measures both the strength of the stratification and intrinsic compressibility. The theoretical bubble terminal velocities are compared against numerical simulations. The PFA model correctly predicts the M dependence at high A, but the model must be further extended to include additional physics to capture the behavior at low A. Undergraduate Scholars Program - Montana State University.

Controlling Rayleigh-Taylor Instabilities in Magnetically Driven Solid Metal Shells by Means of a Dynamic Screw Pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmit, P. F.; Velikovich, A. L.; McBride, R. D.

Magnetically driven implosions of solid metal shells are an effective vehicle to compress materials to extreme pressures and densities. Rayleigh-Taylor instabilities (RTI) are ubiquitous, yet typically undesired features in all such experiments where solid materials are rapidly accelerated to high velocities. In cylindrical shells (“liners”), the magnetic field driving the implosion can exacerbate the RTI. Here, we suggest an approach to implode solid metal liners enabling a remarkable reduction in the growth of magnetized RTI (MRTI) by employing a magnetic drive with a tilted, dynamic polarization, forming a dynamic screw pinch. Our calculations, based on a self-consistent analytic framework, demonstratemore » that the cumulative growth of the most deleterious MRTI modes may be reduced by as much as 1 to 2 orders of magnitude. One key application of this technique is to generate increasingly stable, higher-performance implosions of solid metal liners to achieve fusion [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)]. Finally, we weigh the potentially dramatic benefits of the solid liner dynamic screw pinch against the experimental tradeoffs required to achieve the desired drive field history and identify promising designs for future experimental and computational studies.« less

Rayleigh-Taylor and Richtmyer-Meshkov Instabilities in Turbulent Regime

NASA Astrophysics Data System (ADS)

Dimonte, G.

1998-11-01

The Rayleigh-Taylor instability (RTI) and its shock driven analog, the Richtmyer-Meshkov instability (RMI), affect a wide variety of important phenomena from sub-terrainian to astrophysical environments. The ``fluids" are equally varied from plasmas and magnetic fields to elastic-plastic solids. In most applications, the instabilities occur with a complex acceleration history and evolve to a highly nonlinear state, making the theoretical description formidable. We will link the fluid and plasma regimes while describing the theoretical issues and basic experiments in different venues to isolate key physics issues. RMI experiments on the Nova laser investigate the affects of compressibility with strong radiatively driven shocks (Mach > 10) in near solid density plasmas of sub-millimeter scale. The growth of single sinusoidal and random 3-D perturbations are measured using backlit radiography. RTI experiments with the Linear Electric Motor (LEM) are conducted with a variety of acceleration (<< 10^4 m/s^2) histories and fluids of 10 cm scale. Turbulent RTI experiments with high Reynolds number liquids show self-similar growth which is characterized with laser induced fluorescence. LEM experiments with an elastic-plastic material (yogurt) exhibit a critical wavelength and amplitude for instability. The experimental results will be compared with linear and nonlinear theories and hydrodynamic simulations.

Combination nucleoside/nucleotide reverse transcriptase inhibitors for treatment of HIV infection.

PubMed

Akanbi, Maxwell O; Scarsi, Kimberly K; Scarci, Kimberly; Taiwo, Babafemi; Murphy, Robert L

2012-01-01

The combination of two nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) and a third agent from another antiretroviral class is currently recommended for initial antiretroviral therapy. In general, N(t)RTIs remain relevant in subsequent regimens. There are currently six nucleoside reverse transcriptase inhibitors and one nucleotide reverse transcriptase inhibitor drug entities available, and several formulations that include two or more N(t)RTIs in a fixed-dose combination. These entities have heterogeneous pharmacological and clinical properties. Accordingly, toxicity, pill burden, dosing frequency, potential drug-drug interaction, preexisting antiretroviral drug resistance and comorbid conditions should be considered when constructing a regimen. This approach is critical in order to optimize virologic efficacy and clinical outcomes. This article reviews N(t)RTI combinations used in the treatment of HIV-infected adults. The pharmacological properties of each N(t)RTI, and the clinical trials that have influenced treatment guidelines are discussed. It is likely that N(t)RTIs will continue to dominate the global landscape of HIV treatment and prevention, despite emerging interest in N(t)RTI-free combination therapy. Clinical domains where only few alternatives to N(t)RTIs exist include treatment of HIV/HBV coinfection and HIV-2. There is a need for novel N(t)RTIs with enhanced safety and resistance profiles compared with current N(t)RTIs.

Not all risks are equal: the risk taking inventory for high-risk sports.

PubMed

Woodman, Tim; Barlow, Matt; Bandura, Comille; Hill, Miles; Kupciw, Dominika; Macgregor, Alexandra

2013-10-01

Although high-risk sport participants are typically considered a homogenous risk-taking population, attitudes to risk within the high-risk domain can vary considerably. As no validated measure allows researchers to assess risk taking within this domain, we validated the Risk Taking Inventory (RTI) for high-risk sport across four studies. The RTI comprises seven items across two factors: deliberate risk taking and precautionary behaviors. In Study 1 (n = 341), the inventory was refined and tested via a confirmatory factor analysis used in an exploratory fashion. The subsequent three studies confirmed the RTI's good model-data fit via three further separate confirmatory factor analyses. In Study 2 (n = 518) and in Study 3 (n = 290), concurrent validity was also confirmed via associations with other related traits (sensation seeking, behavioral activation, behavioral inhibition, impulsivity, self-esteem, extraversion, and conscientiousness). In Study 4 (n = 365), predictive validity was confirmed via associations with mean accidents and mean close calls in the high-risk domain. Finally, in Study 4, the self-report version of the inventory was significantly associated with an informant version of the inventory. The measure will allow researchers and practitioners to investigate risk taking as a variable that is conceptually distinct from participation in a high-risk sport.

Controlling Rayleigh-Taylor Instabilities in Magnetically Driven Solid Metal Shells by Means of a Dynamic Screw Pinch

DOE PAGES

Schmit, P. F.; Velikovich, A. L.; McBride, R. D.; ...

2016-11-11

Magnetically driven implosions of solid metal shells are an effective vehicle to compress materials to extreme pressures and densities. Rayleigh-Taylor instabilities (RTI) are ubiquitous, yet typically undesired features in all such experiments where solid materials are rapidly accelerated to high velocities. In cylindrical shells (“liners”), the magnetic field driving the implosion can exacerbate the RTI. Here, we suggest an approach to implode solid metal liners enabling a remarkable reduction in the growth of magnetized RTI (MRTI) by employing a magnetic drive with a tilted, dynamic polarization, forming a dynamic screw pinch. Our calculations, based on a self-consistent analytic framework, demonstratemore » that the cumulative growth of the most deleterious MRTI modes may be reduced by as much as 1 to 2 orders of magnitude. One key application of this technique is to generate increasingly stable, higher-performance implosions of solid metal liners to achieve fusion [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)]. Finally, we weigh the potentially dramatic benefits of the solid liner dynamic screw pinch against the experimental tradeoffs required to achieve the desired drive field history and identify promising designs for future experimental and computational studies.« less

Electronically delivered, multicomponent intervention to reduce unnecessary antibiotic prescribing for respiratory infections in primary care: a cluster randomised trial using electronic health records—REDUCE Trial study original protocol

PubMed Central

Juszczyk, Dorota; Charlton, Judith; McDermott, Lisa; Soames, Jamie; Sultana, Kirin; Ashworth, Mark; Fox, Robin; Hay, Alastair D; Little, Paul; Moore, Michael V; Yardley, Lucy; Prevost, A Toby; Gulliford, Martin C

2016-01-01

Introduction Respiratory tract infections (RTIs) account for about 60% of antibiotics prescribed in primary care. This study aims to test the effectiveness, in a cluster randomised controlled trial, of electronically delivered, multicomponent interventions to reduce unnecessary antibiotic prescribing when patients consult for RTIs in primary care. The research will specifically evaluate the effectiveness of feeding back electronic health records (EHRs) data to general practices. Methods and analysis 2-arm cluster randomised trial using the EHRs of the Clinical Practice Research Datalink (CPRD). General practices in England, Scotland, Wales and Northern Ireland are being recruited and the general population of all ages represents the target population. Control trial arm practices will continue with usual care. Practices in the intervention arm will receive complex multicomponent interventions, delivered remotely to information systems, including (1) feedback of each practice's antibiotic prescribing through monthly antibiotic prescribing reports estimated from CPRD data; (2) delivery of educational and decision support tools; (3) a webinar to explain and promote effective usage of the intervention. The intervention will continue for 12 months. Outcomes will be evaluated from CPRD EHRs. The primary outcome will be the number of antibiotic prescriptions for RTIs per 1000 patient years. Secondary outcomes will be: the RTI consultation rate; the proportion of consultations for RTI with an antibiotic prescribed; subgroups of age; different categories of RTI and quartiles of intervention usage. There will be more than 80% power to detect an absolute reduction in antibiotic prescription for RTI of 12 per 1000 registered patient years. Total healthcare usage will be estimated from CPRD data and compared between trial arms. Ethics and dissemination Trial protocol was approved by the National Research Ethics Service Committee (14/LO/1730). The pragmatic design of the trial will enable subsequent translation of effective interventions at scale in order to achieve population impact. Trial registration number ISRCTN95232781; Pre-results. PMID:27491663

Road traffic injury on rural roads in Tanzania: measuring the effectiveness of a road safety program.

PubMed

Zimmerman, Karen; Jinadasa, Deepani; Maegga, Bertha; Guerrero, Alejandro

2015-01-01

Road traffic injuries (RTIs) are a major public health burden, especially in low- and middle-income countries. There is limited data on RTIs in low-volume, rural African settings. This study attempted to survey all individuals living in households within 200 m of two low-volume rural roads in Tanzania and to collect data on RTIs. Local communities and users of the Bago to Talawanda road (intervention site) and Kikaro to Mihuga road (control site) were targeted and received an intensive program of road safety measures tailored using the crash characteristics of the baseline sample. Demographic data on all household members were collected, and those individuals who suffered an RTI in the previous 3 months had comprehensive information collected about the crash characteristics and the socioeconomic impact. The follow-up data collection occurred nine months after the baseline data were collected. The majority of crashes that caused an RTI involved a motorcycle (71%) and the majority of victims were male (82%) with an average age of 27. Injuries to the legs (55%) were most common and the average length of time away from normal activity was 27 (±33) days. RTI incidence at the intervention site increased during the course of the study (incidence before vs. incidence after) and was unchanged in the community control (incidence before vs. incidence after). The incidence of RTIs in the low-volume rural setting is unacceptably high and most commonly associated with motorcycles. The change in incidence is unreliable due to logistic restraints of the project and more research is needed to quantify the impact of various RTI prevention strategies in this setting. This study provides insight into road traffic injuries on low-volume rural roads, areas where very little research has been captured. Additionally, it provides a replicable study design for those interested in collecting similar data on low-volume rural roads.

Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance.

PubMed

Muniz, Cláudia P; Soares, Marcelo A; Santos, André F

2014-10-01

Interpretation of drug resistance mutation (DRM) has been based solely on HIV-1 subtype B. Reverse transcriptase (RT) C-terminal domains have been disregarded in resistance interpretation, as their clinical relevance is still controversial. We determined the emergence of DRM in RT C-terminal domains of different HIV-1 subtypes, the genetic barrier for the acquisition of these DRM and their temporal appearance with 'classical' RT inhibitor (RTI) mutations. HIV-1 RT sequences were obtained from information from 6087 treatment-naive and 3795 RTI-treated patients deposited in the Stanford HIV Resistance Database, including all major subtypes. DRM emergence was evaluated for subtype B, and was correlated with the number of DRM in the polymerase domain. Genetic barrier was calculated for each DRM studied and in each subtype. N348I, T369I and A360V were found at low prevalence in treatment-naive isolates of all subtypes. A371V was common to treatment-naive isolates. N348I was observed in all subtypes, while T369I was only selected in subtype C. A360V and T369V were selected by RTI treatment in several subtypes. A371V was selected in subtypes B and C, but is a signature in subtype A. RT C-terminal mutations were correlated with early drug resistance in subtype B. All subtypes have a low calculated genetic barrier towards C-terminal DRM acquisition, despite a few disparities having been observed. C-terminal mutations were selected in all HIV-1 subtypes, while some represent subtype-specific signatures. The selection of C-terminal DRMs occurs early in RTI resistance failure in subtype B. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Risk levels for suffering a traffic injury in primary health care. The LESIONAT project.

PubMed

Martín-Cantera, Carlos; Prieto-Alhambra, Daniel; Roig, Lydia; Valiente, Susana; Perez, Katherine; Garcia-Ortiz, Luis; Bel, Jordi; Marques, Fernando; Mundet, Xavier; Bonafont, Xavier; Birules, Marti; Soldevila, Núria; Briones, Elena

2010-03-16

Literature shows that not only are traffic injuries due to accidents, but that there is also a correlation between different chronic conditions, the consumption of certain types of drugs, the intake of psychoactive substances and the self perception of risk (Health Belief Model) and the impact/incidence of traffic accidents. There are few studies on these aspects in primary health care. THE OBJECTIVES of our study are: Main aim: To outline the distribution of risk factors associated with Road Traffic Injuries (RTI) in a driving population assigned to a group of primary health care centres in Barcelona province. Secondly, we aim to study the distribution of diverse risk factors related to the possibility of suffering an RTI according to age, sex and population groups, to assess the relationship between these same risk factors and self risk perception for suffering an RTI, and to outline the association between the number of risk factors and the history of reported collisions. Cross-sectional, multicentre study. 25 urban health care centres. Randomly selected sample of Spanish/Catalan speakers age 16 or above with a medical register in any of the 25 participating primary health care centres. N = 1540.Unit of study: Basic unit of care, consisting of a general practitioner and a nurse, both of whom caring for the same population (1,500 to 2,000 people per unit). Instruments of measurement: Data collection will be performed using a survey carried out by health professionals, who will use the clinical registers and the information reported by the patient during the visit to collect the baseline data: illnesses, medication intake, alcohol and psychoactive consumption, and self perception of risk. We expect to obtain a risk profile of the subjects in relation to RTI in the primary health care field, and to create a group for a prospective follow-up. Clinical Trials.gov Identifier: NCT00778440.

Risk levels for suffering a traffic injury in primary health care. The LESIONAT* project

PubMed Central

2010-01-01

Background Literature shows that not only are traffic injuries due to accidents, but that there is also a correlation between different chronic conditions, the consumption of certain types of drugs, the intake of psychoactive substances and the self perception of risk (Health Belief Model) and the impact/incidence of traffic accidents. There are few studies on these aspects in primary health care. The objectives of our study are: Main aim: To outline the distribution of risk factors associated with Road Traffic Injuries (RTI) in a driving population assigned to a group of primary health care centres in Barcelona province. Secondly, we aim to study the distribution of diverse risk factors related to the possibility of suffering an RTI according to age, sex and population groups, to assess the relationship between these same risk factors and self risk perception for suffering an RTI, and to outline the association between the number of risk factors and the history of reported collisions. Methods/Design Design: Cross-sectional, multicentre study. Setting: 25 urban health care centres. Study population: Randomly selected sample of Spanish/Catalan speakers age 16 or above with a medical register in any of the 25 participating primary health care centres. N = 1540. Unit of study: Basic unit of care, consisting of a general practitioner and a nurse, both of whom caring for the same population (1,500 to 2,000 people per unit). Instruments of measurement: Data collection will be performed using a survey carried out by health professionals, who will use the clinical registers and the information reported by the patient during the visit to collect the baseline data: illnesses, medication intake, alcohol and psychoactive consumption, and self perception of risk. Discussion We expect to obtain a risk profile of the subjects in relation to RTI in the primary health care field, and to create a group for a prospective follow-up. Trial Registration Clinical Trials.gov Identifier: NCT00778440. PMID:20233403

CO{sub 2} Reuse in Petrochemical Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jason Trembly; Brian Turk; Maruthi Pavani

2010-12-31

To address public concerns regarding the consequences of climate change from anthropogenic carbon dioxide (CO{sub 2}) emissions, the U.S. Department of Energy's National Energy Technology Laboratory (DOE/NETL) is actively funding a CO{sub 2} management program to develop technologies capable of mitigating CO{sub 2} emissions from power plant and industrial facilities. Over the past decade, this program has focused on reducing the costs of carbon capture and storage technologies. Recently, DOE/NETL launched an alternative CO{sub 2} mitigation program focused on beneficial CO{sub 2} reuse to support the development of technologies that mitigate emissions by converting CO{sub 2} into valuable chemicals andmore » fuels. RTI, with DOE/NETL support, has been developing an innovative beneficial CO{sub 2} reuse process for converting CO{sub 2} into substitute natural gas (SNG) by using by-product hydrogen (H{sub 2)-containing fuel gas from petrochemical facilities. This process leveraged commercial reactor technology currently used in fluid catalytic crackers in petroleum refining and a novel nickel (Ni)-based catalyst developed by RTI. The goal was to generate an SNG product that meets the pipeline specifications for natural gas, making the SNG product completely compatible with the existing natural gas infrastructure. RTI's technology development efforts focused on demonstrating the technical feasibility of this novel CO{sub 2} reuse process and obtaining the necessary engineering information to design a pilot demonstration unit for converting about 4 tons per day (tons/day) of CO{sub 2} into SNG at a suitable host site. This final report describes the results of the Phase I catalyst and process development efforts. The methanation activity of several commercial fixed-bed catalysts was evaluated under fluidized-bed conditions in a bench-scale reactor to identify catalyst performance targets. RTI developed two fluidizable Ni-based catalyst formulations (Cat-1 and Cat-3) that demonstrated equal or better performance than that of commercial methanation catalysts. The Cat-1 and Cat-3 formulations were successfully scaled up using commercial manufacturing equipment at the Sud-Chemie Inc. pilot-plant facility in Louisville, KY. Pilot transport reactor testing with RTI's Cat-1 formulation at Kellog Brown & Root's Technology Center demonstrated the ability of the process to achieve high single-pass CO{sub 2} conversion. Using information acquired from bench- and pilot-scale testing, a basic engineering design package was prepared for a 4-ton/day CO{sub 2} pilot demonstration unit, including process and instrumentation diagrams, equipment list, control philosophy, and preliminary cost estimate.« less

Application of selection index calculations to determine selection strategies in genomic breeding programs.

PubMed

König, S; Swalve, H H

2009-10-01

The availability of genomic estimated breeding values (GEBV) allows for possible modifications to existing dairy cattle breeding programs. Selection index calculations including genomic and phenotypic observations as index sources were used to determine the optimal number of offspring per genotyped sire with a focus on functional traits and the design of cooperator herds, and to evaluate the importance of a central station test for genotyped bull dams. Evaluation criteria to compare different breeding strategies were correlations between index and aggregate genotype (r(TI)), and the relative selection response percentage (RSR) of an index without single nucleotide polymorphism information in relation to a single nucleotide polymorphism-based index. The number of required daughter records per sire to achieve a predefined r(TI) strongly depends on the accuracy of GEBV (r(mg)) and the heritability of the trait. For a desired r(TI) of 0.8, h(2) = 0.10, and r(mg) = 0.5, at least 57 additional daughters have to be included in the genetic evaluation. Daughter records of genotyped sires are not necessary for optimal scenarios where r(mg) is greater than or equal to r(TI). There still is a substantial need for phenotypic daughter records, especially for low-heritability functional traits and r(mg) < 0.7. Phenotypic records from genotyped potential bull dams have no relevance for increasing r(TI), even with a low value for r(mg) of 0.5. Hence, genomic breeding programs should focus on recording functional traits within progeny groups, preferably in cooperator herds. For low-heritability traits and with r(mg) > 0.7, the RSR of conventional breeding programs was only 10% of RSR from genomic breeding strategies. As shown in scenarios including 2 traits in the index as well as in the aggregate genotype, the availability of highly accurate GEBV for production traits and low-accuracy GEBV for functional traits increased the risk of widening the gap between selection responses in production and functionality. Counteractions are possible, such as via higher economic weights for low-heritability functional traits. Finally, an alternative selection strategy considering only 2 pathways of selection for genotyped male calves and for cow dams was evaluated. This strategy is competitive with a 4-pathway genomic breeding program if the fraction of selected male calves for the artificial insemination program is below 1% and if selection is focused on functionality, thus pointing to substantial insufficiencies caused by low reliabilities of breeding values for cows for such traits in conventional bull dam selection schemes.

Examining the Spatial Frequency Components of a Digital Dental Detector

NASA Astrophysics Data System (ADS)

Anastasiou, A.; Michail, C.; Koukou, V.; Martini, N.; Bakas, A.; Papastamati, F.; Maragkaki, P.; Lavdas, L.; Fountos, G.; Valais, I.; Kalyvas, N.

2017-11-01

Digital X-ray detectors are widely used in dental radiography. The scope of this work is the examination of the spatial frequency component of a dedicated dental CMOS detector. A commercially available SCHICK CDR CMOS detector was irradiated at a Del Medical Eureka X-ray system at 60kVp and 70kVp. The irradiation setup included images of an edge, for Modulation Transfer Function (MTF) calculation. The air-KERMA was measured with an RTI PIRANHA X-ray multimeter. The images were evaluated in ‘for presentation’ format with the use of ImageJ software. The linear range of the detector was found in the range 13μGy-183μGy at 60 kVp and 18μGy-180μGy at 70 kVp. By inspecting the MTF curves it was found that MTF(6lp/mm)60kVp=0.29 and MTF(6lp/mm)70kVp=0.25. The inspection of the Normalized Noise Power Spetrum (NNPS) showed similar low noise components. Our results indicate that this detector presents comparable performance at both kVp, although its X-ray response (pixel value vs air KERMA) was not equal to previously published results, for the same detector type.

The Effect of the Density Ratio on the Nonlinear Dynamics of the Unstable Fluid Interface

NASA Technical Reports Server (NTRS)

Abarzhi, S. I.

2003-01-01

Here we report multiple harmonic theoretical solutions for a complete system of conservation laws, which describe the large-scale coherent dynamics in RTI and RMI for fluids with a finite density ratio in the general three-dimensional case. The analysis yields new properties of the bubble front dynamics. In either RTI or RMI, the obtained dependencies of the bubble velocity and curvature on the density ratio differ qualitatively and quantitatively from those suggested by the models of Sharp (1984), Oron et al. (2001), and Goncharov (2002). We show explicitly that these models violate the conservation laws. For the first time, our theory reveals an important qualitative distinction between the dynamics of the RT and RM bubbles.

Interface width effect on the classical Rayleigh-Taylor instability in the weakly nonlinear regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L. F.; State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Beijing 100083; Ye, W. H.

2010-05-15

In this paper, the interface width effects (i.e., the density gradient effects or the density transition layer effects) on the Rayleigh-Taylor instability (RTI) in the weakly nonlinear (WN) regime are investigated by numerical simulation (NS). It is found that the interface width effects dramatically influence the linear growth rate in the linear growth regime and the mode coupling process in the WN growth regime. First, the interface width effects decrease the linear growth rate of the RTI, particularly for the short perturbation wavelengths. Second, the interface width effects suppress (reduce) the third-order feedback to the fundamental mode, which induces themore » nonlinear saturation amplitude (NSA) to exceed the classical prediction, 0.1lambda. The wider the density transition layer is, the larger the NSA is. The NSA in our NS can reach a half of its perturbation wavelength. Finally, the interface width effects suppress the generation and the growth of the second and the third harmonics. The ability to suppress the harmonics' growth increases with the interface width but decreases with the perturbation wavelength. On the whole, in the WN regime, the interface width effects stabilize the RTI, except for an enhancement of the NSA, which is expected to improve the understanding of the formation mechanism for the astrophysical jets, and for the jetlike long spikes in the high energy density physics.« less

Clinical role of Cefixime in community-acquired infections.

PubMed

Dreshaj, Sh; Doda-Ejupi, T; Tolaj, I Q; Mustafa, A; Kabashi, S; Shala, N; Geca, Nj; Aliu, A; Daka, A; Basha, N

2011-01-01

Cefixime is an oral third generation cephalosporin, frequently used in respiratory tract infections (RTI) in the pediatric population. However, in some publications cefixime has demonstrated poor efficacy against staphylococci and streptococci. of this study was to evaluate the efficacy of cefixime in the treatment of community-acquired infections in a country where parenteral third generation cephalosporins have been used for a long time. The present study was designed to assess the clinical efficacy, bacteriological eradication rates and tolerability of cefixime in children with community-acquired upper RTI (URTI), lower RTI (LRTI) and uncomplicated urinary tract infections (UTI). The study was prospective, open, and included 89 patients, from 6 months to 28 years, of both sexes, with the diagnosis of community-acquired URTI, LRTI and UTI. The treatment with cefixime was successful in 30/30 (100%) patients suffering from acute otitis media (AOM), in 10/12 (83.3%) with acute sinusitis, in 12/12 patients (100%) with pneumonia, in 31/35 (88.57) with uncomplicated UTI. The antibiotic was well tolerated. In 10 days treatment we recorded one case (1.3%) with acute gastroenteritis and two cases (2.6%) of maculopapular rash. Side-effects were transient and disappeared after finishing therapy in all three of the cases. Community-acquired infections, such as AOM, LRTI and UTI, caused by susceptible pathogens, can be treated with cefixime, as a good choice for a successful clinical response.

Effects of performance feedback and coaching on the problem-solving process: Improving the integrity of implementation and enhancing student outcomes

NASA Astrophysics Data System (ADS)

Lundahl, Allison A.

Schools implementing Response to Intervention (RtI) procedures frequently engage in team problem-solving processes to address the needs of students who require intensive and individualized services. Because the effectiveness of the problem-solving process will impact the overall success of RtI systems, the present study was designed to learn more about how to strengthen the integrity of the problem-solving process. Research suggests that school districts must ensure high quality training and ongoing support to enhance the effectiveness, acceptability, and sustainability of the problem-solving process within an RtI model; however, there is a dearth of research examining the effectiveness of methods to provide this training and support. Consequently, this study investigated the effects of performance feedback and coaching strategies on the integrity with which teams of educators conducted the problem-solving process in schools. In addition, the relationships between problem-solving integrity, teacher acceptability, and student outcomes were examined. Results suggested that the performance feedback increased problem-solving procedural integrity across two of the three participating schools. Conclusions about the effectiveness of the (a) coaching intervention and (b) interventions implemented in the third school were inconclusive. Regression analyses indicated that the integrity with which the teams conducted the problem-solving process was a significant predictor of student outcomes. However, the relationship between problem-solving procedural integrity and teacher acceptability was not statistically significant.

[Investigation on reproductive tract infection among floating married women of childbearing age in Fengtai district in Beijing].

PubMed

Zhang, Li-jie; Geng, Yu-tian; An, Hui-yan; Gao, Shu-yun; Zhang, Ling; Cen, Yang; Zeng, Guang

2003-08-01

In order to develop plans for effective intervention measures, prevalence and health-seeking behavior related to reproductive tract infection among floating married women of childbearing age in Fengtai district in Beijing were studied. Cross-sectional study was carried out. Two thousand and sixty-nine eligible women were randomly selected from strata based on their home provinces. From June to July 2001, the subjects were given face-to-face interview at the Fengtai family planning clinic in Beijing using standard questionnaire followed by gynecologic examination and laboratory tests. Thirty point three percent of the subjects were found to have reproductive tract infections (RTI) by laboratory tests. Prevalence rates of bacterial vaginosis, candida and trichomonas vaginitis were 22.2%, 4.9% and 2.1% respectively. Prevalence rates of chlamydia, gonorrhea, condyloma acuminatum and syphilis were 2.2%, 1.6%, 0.5% and 0.2% respectively. Of these infected women, only 43.1% (270/626) were symptomatic, and 61.5% (166/270) of these women with symptoms had sought treatment. Compared to other results in the literature, we found a relatively high prevalence of RTI in our study population. Only a small proportion of these infected women were symptomatic but only few of them sought treatment. We suggested that the provision of more family planning service and promotion of RTI knowledge to the floating women of childbearing age.

Economic Burden of Hospitalization Due to Injuries in North India: A Cohort Study

PubMed Central

Prinja, Shankar; Jagnoor, Jagnoor; Chauhan, Akashdeep Singh; Aggarwal, Sameer; Nguyen, Ha; Ivers, Rebecca

2016-01-01

There is little documentation of the potential catastrophic effects of injuries on families due to out of pocket (OOP) expenditure for medical care. Patients who were admitted for at least one night in a tertiary care hospital of Chandigarh city due to injury were recruited and were followed-up at 1, 2 and 12 months after discharge to collect information on OOP expenditure. Out of the total 227 patients, 60% (137/227) had sustained road traffic injuries (RTI). The average OOP expenditure per hospitalisation and up to 12 months post discharge was USD 388 (95% CI: 332–441) and USD 1046 (95% CI: 871–1221) respectively. Mean OOP expenditure for RTI and non-RTI cases during hospitalisation was USD 400 (95% CI: 344–456) and USD 369 (95% CI: 313–425) respectively. The prevalence of catastrophic expenditure was 30%, and was significantly higher among those belonging to the lowest income quartile (OR-26.50, 95% CI: 6.70–105.07, p-value: <0.01) and with an inpatient stay greater than 7 days (OR-10.60, 95% CI: 4.21–26.64, p-value: <0.01). High OOP expenditure for treatment of injury puts a significant economic burden on families. Measures aimed at increasing public health spending for prevention of injury and providing financial risk protection are urgently required in India. PMID:27384572

75 FR 75963 - Export Trade Certificate of Review

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... location). The controlling entity remains the Carlyle Group, Washington, DC; Computer Sciences Corporation..., Littleton, CO; RTI International Materials Inc., has moved from Niles, OH, to Pittsburgh, PA; Science...

Direct simulation Monte Carlo investigation of the Rayleigh-Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallis, M. A.; Koehler, T. P.; Torczynski, J. R.

In this paper, the Rayleigh-Taylor instability (RTI) is investigated using the direct simulation Monte Carlo (DSMC) method of molecular gas dynamics. Here, fully resolved two-dimensional DSMC RTI simulations are performed to quantify the growth of flat and single-mode perturbed interfaces between two atmospheric-pressure monatomic gases as a function of the Atwood number and the gravitational acceleration. The DSMC simulations reproduce many qualitative features of the growth of the mixing layer and are in reasonable quantitative agreement with theoretical and empirical models in the linear, nonlinear, and self-similar regimes. In some of the simulations at late times, the instability enters themore » self-similar regime, in agreement with experimental observations. Finally, for the conditions simulated, diffusion can influence the initial instability growth significantly.« less

Direct simulation Monte Carlo investigation of the Rayleigh-Taylor instability

DOE PAGES

Gallis, M. A.; Koehler, T. P.; Torczynski, J. R.; ...

2016-08-31

In this paper, the Rayleigh-Taylor instability (RTI) is investigated using the direct simulation Monte Carlo (DSMC) method of molecular gas dynamics. Here, fully resolved two-dimensional DSMC RTI simulations are performed to quantify the growth of flat and single-mode perturbed interfaces between two atmospheric-pressure monatomic gases as a function of the Atwood number and the gravitational acceleration. The DSMC simulations reproduce many qualitative features of the growth of the mixing layer and are in reasonable quantitative agreement with theoretical and empirical models in the linear, nonlinear, and self-similar regimes. In some of the simulations at late times, the instability enters themore » self-similar regime, in agreement with experimental observations. Finally, for the conditions simulated, diffusion can influence the initial instability growth significantly.« less

Integrated Mission Simulation (IMSim): Multiphase Initialization Design with Late Joiners, Rejoiners and Federation Save & Restore

NASA Technical Reports Server (NTRS)

Dexter, Daniel E.; Varesic, Tony E.

2015-01-01

This document describes the design of the Integrated Mission Simulation (IMSim) federate multiphase initialization process. The main goal of multiphase initialization is to allow for data interdependencies during the federate initialization process. IMSim uses the High Level Architecture (HLA) IEEE 1516 [1] to provide the communication and coordination between the distributed parts of the simulation. They are implemented using the Runtime Infrastructure (RTI) from Pitch Technologies AB. This document assumes a basic understanding of IEEE 1516 HLA, and C++ programming. In addition, there are several subtle points in working with IEEE 1516 and the Pitch RTI that need to be understood, which are covered in Appendix A. Please note the C++ code samples shown in this document are for the IEEE 1516-2000 standard.

Bench-Scale Development of a Non-Aqueous Solvent (NAS) CO2 Capture Process for Coal-Fired Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lail, Marty

The project aimed to advance RTI’s non-aqueous amine solvent technology by improving the solvent to reduce volatility, demonstrating long-term continuous operation at lab- (0.5 liters solvent) and bench-scale (~120 liters solvent), showing low reboiler heat duty measured during bench-scale testing, evaluating degradation products, building a rate-based process model, and evaluating the techno-economic performance of the process. The project team (RTI, SINTEF, Linde Engineering) and the technology performed well in each area of advancement. The modifications incorporated throughout the project enabled the attainment of target absorber and regenerator conditions for the process. Reboiler duties below 2,000 kJt/kg CO2 were observed inmore » a bench-scale test unit operated at RTI.« less

Bone mineral density and inflammatory and bone biomarkers after darunavir-ritonavir combined with either raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults with HIV-1: a substudy of the NEAT001/ANRS143 randomised trial.

PubMed

Bernardino, Jose I; Mocroft, Amanda; Mallon, Patrick W; Wallet, Cedrick; Gerstoft, Jan; Russell, Charlotte; Reiss, Peter; Katlama, Christine; De Wit, Stephane; Richert, Laura; Babiker, Abdel; Buño, Antonio; Castagna, Antonella; Girard, Pierre-Marie; Chene, Genevieve; Raffi, Francois; Arribas, Jose R

2015-11-01

Osteopenia, osteoporosis, and low bone mineral density are frequent in patients with HIV. We assessed the 96 week loss of bone mineral density associated with a nucleoside or nucleotide reverse transcriptase inhibitor (NtRTI)-sparing regimen. Antiretroviral-naive adults with HIV were enrolled in 78 clinical sites in 15 European countries into a randomised (1:1), open-label, non-inferiority trial (NEAT001/ANRS143) assessing the efficacy and safety of darunavir (800 mg once per day) and ritonavir (100 mg once per day) plus either raltegravir (400 mg twice per day; NtRTI-sparing regimen) or tenofovir (245 mg once per day) and emtricitabine (200 mg once per day; standard regimen). For this bone-health substudy, 20 of the original sites in six countries participated, and any patient enrolled at one of these sites who met the following criteria was eligible: plasma viral loads greater than 1000 HIV RNA copies per mL and CD4 cell counts of fewer than 500 cells per μL, except in those with symptomatic HIV infection. Exclusion criteria included treatment for malignant disease, testing positive for hepatitis B virus surface antigen, pregnancy, creatinine clearance less than 60 mL per min, treatment for osteoporosis, systemic steroids, or oestrogen-replacement therapy. The two primary endpoints were the mean percentage changes in lumbar spine and total hip bone mineral density at week 48, assessed by dual energy x-ray absorptiometry (DXA) scans. We did the analysis with an intention-to-treat-exposed approach with antiretroviral modifications ignored. The parent trial is registered with ClinicalTrials.gov, number NCT01066962, and is closed to new participants. Between Aug 2, 2010, and April 18, 2011, we recruited 146 patients to the substudy, 70 assigned to the NtRTI-sparing regimen and 76 to the standard regimen. DXA data were available for 129, 121 and 107 patients at baseline, 48 and 96 weeks respectively. At week 48, the mean percentage loss in bone mineral density in the lumbar spine was greater in the standard group than in the NtRTI-sparing group (mean percentage change -2.49% vs -1.00%, mean percentage difference -1.49, 95% CI -2.94 to -0.04; p=0.046). Total hip bone mineral density loss was similarly greater at week 48 in the standard group than in the NtRTI-sparing group (mean percentage change -3.30% vs -0.73%; mean percentage difference -2.57, 95% CI -3.75 to -1.35; p<0.0001). Seven new fractures occurred during the trial (two in the NtRTI-sparing group and five in the standard group). A raltegravir-based regimen was associated with significantly less loss of bone mineral density than a standard regimen containing tenofovir disoproxil fumarate, and might be a treatment option for patients at high risk of osteopenia or osteoporosis who are not suitable for NtRTIs such as abacavir or tenofovir alafenamide. The European Union Sixth Framework Programme, Inserm-ANRS, Ministerio de Sanidad y Asuntos Sociales de España, Gilead Sciences, Janssen Pharmaceuticals, and Merck Laboratories. Copyright © 2015 Elsevier Ltd. All rights reserved.

Electronically delivered, multicomponent intervention to reduce unnecessary antibiotic prescribing for respiratory infections in primary care: a cluster randomised trial using electronic health records-REDUCE Trial study original protocol.

PubMed

Juszczyk, Dorota; Charlton, Judith; McDermott, Lisa; Soames, Jamie; Sultana, Kirin; Ashworth, Mark; Fox, Robin; Hay, Alastair D; Little, Paul; Moore, Michael V; Yardley, Lucy; Prevost, A Toby; Gulliford, Martin C

2016-08-04

Respiratory tract infections (RTIs) account for about 60% of antibiotics prescribed in primary care. This study aims to test the effectiveness, in a cluster randomised controlled trial, of electronically delivered, multicomponent interventions to reduce unnecessary antibiotic prescribing when patients consult for RTIs in primary care. The research will specifically evaluate the effectiveness of feeding back electronic health records (EHRs) data to general practices. 2-arm cluster randomised trial using the EHRs of the Clinical Practice Research Datalink (CPRD). General practices in England, Scotland, Wales and Northern Ireland are being recruited and the general population of all ages represents the target population. Control trial arm practices will continue with usual care. Practices in the intervention arm will receive complex multicomponent interventions, delivered remotely to information systems, including (1) feedback of each practice's antibiotic prescribing through monthly antibiotic prescribing reports estimated from CPRD data; (2) delivery of educational and decision support tools; (3) a webinar to explain and promote effective usage of the intervention. The intervention will continue for 12 months. Outcomes will be evaluated from CPRD EHRs. The primary outcome will be the number of antibiotic prescriptions for RTIs per 1000 patient years. Secondary outcomes will be: the RTI consultation rate; the proportion of consultations for RTI with an antibiotic prescribed; subgroups of age; different categories of RTI and quartiles of intervention usage. There will be more than 80% power to detect an absolute reduction in antibiotic prescription for RTI of 12 per 1000 registered patient years. Total healthcare usage will be estimated from CPRD data and compared between trial arms. Trial protocol was approved by the National Research Ethics Service Committee (14/LO/1730). The pragmatic design of the trial will enable subsequent translation of effective interventions at scale in order to achieve population impact. ISRCTN95232781; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Direct and indirect selection of visceral lipid weight, fillet weight, and fillet percentage in a rainbow trout breeding program.

PubMed

Kause, A; Paananen, T; Ritola, O; Koskinen, H

2007-12-01

We assessed whether visceral lipid weight, fillet weight, and percentage fillet from BW, 3 traits laborious to record, could be genetically improved by indirect selection on more easily measured traits in farmed rainbow trout. Visceral lipid is discarded as waste during slaughter, influencing production efficiency and production costs. Fillet weight and fillet percentage directly influence economic returns in trout production. The study comprised 3 steps. First, we assessed the degree to which selection on percentage of visceral weight from BW indirectly changes visceral lipid weight and the size of intestines and internal organs. The phenotypic analysis of weights of viscera, intestines, visceral lipid, liver, and gonads measured from 40 fish revealed that phenotypic selection against visceral weight was most strongly directed to visceral lipid, and to a lesser degree to intestines and gonads. Because genetic relationships among these traits were not established, it is not known whether indirect selection leads to genetic responses. Second, we examined whether direct selection for the fillet traits could be replaced by indirect selection on BW, eviscerated BW, visceral weight, visceral percentage, head volume, and relative head volume (head volume relative to BW). The selection index calculations based on the quantitative genetic parameters obtained from multigenerational pedigree data showed that genetic improvement of fillet percentage through direct selection (selection accuracy, r(TI) = 0.54) was equally efficient compared with indirect selection on visceral percentage ( r(TI) = 0.54). Genetic improvement of fillet weight through direct selection (r(TI) = 0.56) was always more efficient than indirect selection, yet indirect selection for eviscerated BW ( r(TI) = 0.50) was almost as efficient as direct selection. Third, the expected genetic responses to alternative selection indices showed that improved fillet percentage was mainly a result of a moderate decrease in visceral weight rather than of a major increase in absolute fillet weight. Moreover, fillet percentage is challenging to improve, even if it exhibits moderate heritability (h(2) = 0.29). This is because fillet percentage displays low phenotypic variation. In conclusion, fillet weight and fillet percentage can be increased by indirect selection against visceral percentage and for high eviscerated BW.

Marketplace strategy contract.

DOT National Transportation Integrated Search

2014-02-25

The Heartland Intermodal Gateway (HIG) in Prichard, WV is dedicated to providing a : corridor for double-stacked rail across what is known as the heartland of the United : States. The Rahall Transportation Institute (RTI) was tasked with assist...

Experiments of the highly non-linear Rayleigh-Taylor instability regime and dependence on Atwood Number

NASA Astrophysics Data System (ADS)

Elgin, L.; Handy, T.; Malamud, G.; Huntington, C. M.; Trantham, M. R.; Klein, S. R.; Kuranz, C. C.; Drake, R. P.; Shvarts, D.

2017-10-01

Potential flow models predict that a Rayleigh-Taylor unstable system will reach a terminal velocity (and constant Froude number) at low Atwood numbers. Numerical simulations predict a re-acceleration phase of Rayleigh-Taylor Instability (RTI) and higher Froude number at late times. To observe this effect, we are conducting a series of experiments at OMEGA 60 to measure single-mode RTI growth at low and high Atwood numbers and late times. X-ray radiographs spanning 40 + ns capture the evolution of these systems. Experimental design challenges and initial results are discussed here. This work is funded by the Lawrence Livermore National Laboratory under subcontract B614207, and was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344.

Dinuclear Tricyclic Transition State Model for Carbonyl Addition of Organotitanium Reagents: DFT Study on the Activity and Enantioselectivity of BINOLate Titanium Catalysts.

PubMed

Harada, Toshiro

2018-06-08

In the presence of a catalytic amount of chiral BINOL derivatives (or BINOLs), a mixture of various organometallic compounds with Ti(O i Pr) 4 undergoes enantioselective addition to aldehydes and ketones. Although the catalyst and reacting nucleophile of the reaction have been elucidated to be ( BINOLate)Ti 2 (O i Pr) 6 and RTi(O i Pr) 3 , respectively, little is known about the properties of short-lived intermediates and transition structures. In this work, the mechanism of this reaction is investigated with the aid of DFT (M06) calculations. The study provides support for the following mechanistic understandings: (i) The direct racemic reaction proceeds through a pathway involving initial aggregation of RTi(O i Pr) 3 with Ti(O i Pr) 4 followed by carbonyl addition of the resulting dinuclear aggregate. (ii) The enantioselective reaction takes place through a pathway involving initial ligand exchange of RTi(O i Pr) 3 with ( BINOLate)Ti 2 (O i Pr) 6 followed by the addition of the resulting chiral dinuclear titanium species via a chiral BINOLate-chelated, tricyclic transition structure. (iii) The enantioselective pathway is favorable not because BINOLate ligands accelerate the carbonyl addition but because the ligands stabilize the chiral dinuclear species against deaggregation through a chelating bridge. (iv) The chiral transition structure serves as a model accounting for the re-face addition generally observed in the reaction of aldehydes with ( R)- BINOLs.

A successful model of Road Traffic Injury surveillance in a developing country: process and lessons learnt.

PubMed

Razzak, Junaid Abdul; Shamim, Muhammad Shahzad; Mehmood, Amber; Hussain, Syed Ameer; Ali, Mir Shabbar; Jooma, Rashid

2012-05-16

Road Traffic Injuries (RTIs) are one of the leading causes of death and disability worldwide with 90% of global mortality concentrated in the low and middle income countries. RTI surveillance is recommended to define the burden, identify high risk groups, plan intervention and monitor their impact. Despite its stated importance in the literature, very few examples of sustained surveillance systems are reported from low income countries. This paper shares the experience of setting up an urban RTI surveillance program in the emergency departments of five major hospitals in Karachi, Pakistan. We describe the process of establishing a surveillance system including assembling a multi-institution research group, developing a data collection methodology, carrying out data collection and analysis and dissemination of information to the relevant stakeholders. In the absence of a road safety agency, the surveillance system required developing individual partnerships with industry, police, city government, media and many other stakeholders. Impact of the surveillance is demonstrated by some initiatives in the local trauma system and improvements in road design to effect hazard reduction. We demonstrated that a functional RTI surveillance program can be established, and effectively managed in a developing country, despite lack of infrastructure and limitation of resources. Data utilization in the absence of well defined road safety infrastructure within the government is a challenge. More effective actions are hampered by the limited capacity in the transport and health sectors to do in-depth analysis through road safety audits and trauma registries.

Clinical, social and relational determinants of paediatric ambulatory drug prescriptions due to respiratory tract infections in Italy.

PubMed

Ciofi degli Atti, Marta Luisa; Massari, Marco; Bella, Antonino; Boccia, Delia; Filia, Antonietta; Salmaso, Stefania

2006-12-01

Collecting information on patterns of drug prescriptions and on factors influencing prescribing decisions is fundamental for supporting the rational use of drugs. This study was aimed at investigating patterns of drug prescription in paediatric outpatients and at evaluating determinants of prescriptions for respiratory tract infections (RTIs). We conducted a national cross-sectional survey involving primary care paediatricians and parents. Diagnoses and prescriptions made at each consultation were described. Poisson regression models were used to analyse determinants of drug and antibiotic prescriptions for visits due to RTIs. A total of 4,302 physician and parent questionnaires were analysed. These corresponded to 2,151 visits, 792 of which were due to RTIs. Drugs were prescribed in 83.4% of RTI visits, while antibiotics were prescribed in 40.4%. According to paediatricians' perceptions, 84.2% of parents of children with a RTI expected to receive a drug prescription. Paediatricians' perception of parental expectations was the strongest determinant for prescription of drugs and specifically of antibiotics [adjusted relative risk (RR): 1.7 and 3.6, respectively; P < 0.001]. However, in 77.1% of RTI visits, paediatricians judged themselves as not being influenced at all by parents' expectations in their decision to prescribe. This study underscores that relational factors, in particular perceived parental expectations, are one of the leading factors of drug prescriptions in paediatric ambulatory care settings, reinforcing the opinion that communication between physicians and parents can affect prescription patterns.

[Studies on chemical components of essential oil of crude semen sinapis and roasted semen sinapis].

PubMed

Chen, Mi-Yu; Lin, Yan-Ni; Wu, Guo-Xin; Wu, Cui-Ping

2006-07-01

To study the chemical components of the essential oil of the Semen Sinapis with the different processing methods. The essential oils of the crude Semen Sinapis and the roasted Semen Sinapis were extracted by steam distillation. The chemical components were analyzed by means of GC-MS-DS. The relative content of each component was calculated by area normalization. The main chemical components of the essential oil of the crude Semen Sinapis and the roasted Semen Sinapis were similar. The main chemical components were allyl isothiocyanate and 4-isothio-cyanato-1-butene. The chemical components of the essential oil of the crude Semen Sinapis were more than that of the roasted Semen Sinapis. The effect of different processing methods on the chemical components of the essential oil of Semen Sinapis was significant. Certain chemical components such as isothiocyanato-containing substances, were found in the crude Semen Sinapis.

National Aeronautics and Space Administration technology application team program

NASA Technical Reports Server (NTRS)

1972-01-01

Contracts are reported between the RTI TATeam and the National Aeronautics and Space Administration (NASA), the Environmental Protection Agency (EPA), and other governmental, educational, and industrial organizations participating in NASA's Technology Utilization Program.

Characteristics of Pregnant Teen Substance Abuse Treatment Admissions

MedlinePlus

... Set (TEDS) is an administrative data system providing descriptive information about the national flow of admissions aged ... Management Decisions, Inc., Arlington, VA; and RTI International, Research Triangle Park, NC. Information and data for this ...

Coatings Guide

EPA Science Inventory

The Coatings Guide is a free online information resource that focuses on alternative, low-emission coatings for metal, plastic, and architectural substrates. Developed cooperatively by the U.S. EPA's Office of Research and Development and Research Triangle Institute (RTI) Interna...

RTI special studies for TxDOT administration in FY 2010.

DOT National Transportation Integrated Search

2011-01-01

This research project was established by TxDOTs Research and Technology Implementation Office to address : special studies required by the departments Administration during FY 2010. Six short-term, quick-turnaround : tasks were completed and ar...

North Region ROW tool implementation workshop.

DOT National Transportation Integrated Search

2010-08-02

Welcome to the North Region ROW Tool Workshop. This workshop is funded under an implementation project sponsored by TxDOTs Research & Technology Implementation Office (RTI). This is the second of four regional workshops being planned for this summ...

The improvement of reading skills of L1 and ESL children using a Response to Intervention (RtI) Model.

PubMed

Lipka, Orly; Siegel, Linda S

2010-11-01

This study examined the development of literacy skills in children in a district that used a Response to Intervention (RTI) model. The district included children whose first language was English and children who were learning English as a second language (ESL). Tasks measuring phonological awareness, lexical access, and syntactic awareness were administered when the children entered school in kindergarten at age 5. Reading, phonological processing, syntactic awareness, memory, and spelling were administered in grade 7. When the children entered school, significant numbers of them were at risk for literacy difficulties. After systematic instruction and annual monitoring of skills, their reading abilities improved to the extent that only a very small percentage had reading difficulties. The results demonstrated that early identification and intervention and frequent monitoring of basic skills can significantly reduce the incidence of reading problems in both the ESL and language majority children.

Optimization of Advanced ACTPol Transition Edge Sensor Bolometer Operation Using R(T,I) Transition Measurements

NASA Astrophysics Data System (ADS)

Salatino, Maria

2017-06-01

In the current submm and mm cosmology experiments the focal planes are populated by kilopixel transition edge sensors (TESes). Varying incoming power load requires frequent rebiasing of the TESes through standard current-voltage (IV) acquisition. The time required to perform IVs on such large arrays and the resulting transient heating of the bath reduces the sky observation time. We explore a bias step method that significantly reduces the time required for the rebiasing process. This exploits the detectors' responses to the injection of a small square wave signal on top of the dc bias current and knowledge of the shape of the detector transition R(T,I). This method has been tested on two detector arrays of the Atacama Cosmology Telescope (ACT). In this paper, we focus on the first step of the method, the estimate of the TES %Rn.

An independent review of the Multi-Path Redundant Avionics Suite (MPRAS) architecture assessment and characterization report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, M.R.

1991-02-01

In recent years the NASA Langley Research Center has funded several contractors to conduct conceptual designs defining architectures for fault tolerant computer systems. Such a system is referred to as a Multi-Path Redundant Avionics Suite (MPRAS), and would form the basis for avionics systems that would be used in future families of space vehicles in a variety of missions. The principal contractors were General Dynamics, Boeing, and Draper Laboratories. These contractors participated in a series of review meetings, and submitted final reports defining their candidate architectures. NASA then commissioned the Research Triangle Institute (RTI) to perform an assessment of thesemore » architectures to identify strengths and weaknesses of each. This report is a separate, independent review of the RTI assessment, done primarily to assure that the assessment was comprehensive and objective. The report also includes general recommendations relative to further MPRAS development.« less

Thermal actuation of extinguishing systems

NASA Astrophysics Data System (ADS)

Evans, D. D.

1984-03-01

A brief review of the Response Time Index (RTI) method of characterizing the thermal response of commercial sprinklers and heat detectors is presented. Measured ceiling layer flow temperature and velocity histories from a bedroom fire test are used to illustrate the use of RTI in calculating sprinkler operation times. In small enclosure fires, a quiescent warm gas layer confined by the room walls may accumulate below the ceiling before sprinkler operation. The effects of this warm gas layer on the fire plume and ceiling jet flows are accounted for by substitution of an equivalent point source fire. Encouraging agreement was found between measured ceiling jet temperatures from steady fires in a laboratory scale cylindrical enclosure put into dimensionless form based on parameters of the substitute fire source, and existing empirical correlations from fire tests in large enclosures in which a quiescent warm upper gas layer does not accumulate.

Strategies for prevention of road traffic injuries (RTIs) in Pakistan: situational analysis.

PubMed

Khan, Adeel Ahmed; Fatmi, Zafar

2014-05-01

Road traffic injuries (RTIs) are one of the leading causes of death among productive age group. Using systems approach framework (SAF), current preventive strategies for RTI control were reviewed in Pakistan. A review of the literature was done using four international search engines. Only ten studies on preventive strategies for RTI stemming from Pakistan were found. The first Road Traffic Injuries Research Network (RTIRN) surveillance system for road traffic injuries was established in urban city (Karachi) in Pakistan has shown promise for injury control and should be scaled up to other cities. Enforcement of traffic laws on seat-belt and helmet wearing is poor. National Highway and Motorway Police Ordinance (2000) was one of the few legislative measure so far taken in Pakistan. Using SAF, efforts are required to implement interventions targeting human, vehicle design and also making environment safer for road users.

Procurement of State-of-the-Art Research Equipment to Support Faculty Members Within the RNAi Therapeutics Institute

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terence Flotte, MD; Patricia McNulty

2010-06-29

This project funded the procurement of state-of-the-art research equipment to support world class faculty members within the RNAi Therapeutics Institute, a central program of the Advanced Therapeutics Cluster (ATC) project. The equipment purchased under this grant supports the RNA Therapeutics Institute (RTI) at the University of Massachusetts Medical School which seeks to build a community of scientists passionate about RNA. By uniting researchers studying the fundamental biology and mechanisms of cellular RNAs with those working to devise human therapies using or targeting nucleic acids, the RTI represents a new model for scientific exploration. By interweaving basic and applied nucleic acidmore » scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.« less

Dense Array Studies of Volcano-Tectonic and Long-Period Earthquakes Beneath Mount St. Helens

NASA Astrophysics Data System (ADS)

Glasgow, M. E.; Hansen, S. M.; Schmandt, B.; Thomas, A.

2017-12-01

A 904 single-component 10-Hz geophone array deployed within 15 km of Mount St. Helens (MSH) in 2014 recorded continuously for two-weeks. Automated reverse-time imaging (RTI) was used to generate a catalog of 212 earthquakes. Among these, two distinct types of upper crustal (<8 km) earthquakes were classified. Volcano-tectonic (VT) and long-period (LP) earthquakes were identified using analysis of array spectrograms, envelope functions, and velocity waveforms. To remove analyst subjectivity, quantitative classification criteria were developed based on the ratio of power in high and low frequency bands and coda duration. Prior to the 2014 experiment, upper crustal LP earthquakes had only been reported at MSH during volcanic activity. Subarray beamforming was used to distinguish between LP earthquakes and surface generated LP signals, such as rockfall. This method confirmed 16 LP signals with horizontal velocities exceeding that of upper crustal P-wave velocities, which requires a subsurface hypocenter. LP and VT locations overlap in a cluster slightly east of the summit crater from 0-5 km below sea level. LP displacement spectra are similar to simple theoretical predictions for shear failure except that they have lower corner frequencies than VT earthquakes of similar magnitude. The results indicate a distinct non-resonant source for LP earthquakes which are located in the same source volume as some VT earthquakes (within hypocenter uncertainty of 1 km or less). To further investigate MSH microseismicity mechanisms, a 142 three-component (3-C) 5 Hz geophone array will record continuously for one month at MSH in Fall 2017 providing a unique dataset for a volcano earthquake source study. This array will help determine if LP occurrence in 2014 was transient or if it is still ongoing. Unlike the 2014 array, approximately 50 geophones will be deployed in the MSH summit crater directly over the majority of seismicity. RTI will be used to detect and locate earthquakes by back-projecting 3-C data with a local 3-D P and S velocity model. Earthquakes will be classified using the previously stated techniques, and we will seek to use the dense array of 3-C waveforms to invert for focal mechanisms and, ideally, moment tensor sources down to M0.

Guaifenesin has no effect on sputum volume or sputum properties in adolescents and adults with acute respiratory tract infections.

PubMed

Hoffer-Schaefer, Agathe; Rozycki, Henry J; Yopp, Melissa A; Rubin, Bruce K

2014-05-01

Guaifenesin (glyceryl guaiacolate ether [GGE]) has been studied as a cough suppressant and as an expectorant; however, published studies to date have failed to find a consistent benefit. An 8-day multi-center clinical trial was conducted to study the effect of two 600-mg extended-release GGE tablets twice daily for 1 week on cold symptoms, sputum volume, and properties in adolescents and adults with productive cough from an acute respiratory tract infection (RTI). The study enrolled 378 subjects (GGE, n = 188; and placebo, n = 190) who were otherwise healthy and had an RTI for up to 5 days before enrollment. Subjects suffered from at least 2 of 3 symptoms of cough, thickened mucus, and chest congestion. A total of 151 GGE and 144 control subjects completed the full protocol. Single-sputum samples were collected from each subject on days 1, 3, 4, and 8 of the study. The rheology and interfacial tension of sputum were measured, and 24-h collected samples from days 1 and 4 were analyzed for total volume and hydration. Symptoms in both the GGE and placebo groups improved to a similar degree over time. There were no significant differences between the GGE and placebo groups for sputum volume (P = .41), percent solids (P = .69), interfacial tension (P = .88), elasticity (P = .71), viscosity (P = .45), or mechanical impedance (P = .75). The recommended dose of GGE had no measurable effect on sputum volume or properties and is unlikely to be an expectorant or mucolytic when used to treat acute RTI. (ClinicalTrials.gov registration NCT01046136.).

Host, vehicular and environmental factors responsible for road traffic crashes in a Nigerian city: identifiable issues for road traffic injury control.

PubMed

Adeoye, Peter Oladapo; Kadri, Dotun Musiliu; Bello, Jibril Oyekunle; Ofoegbu, Chima Kingsley Pascal; Abdur-Rahman, Lukman Olajide; Adekanye, Adedeji Olugbenga; Solagberu, Babatunde Akeeb

2014-01-01

Road traffic injury (RTI) has assumed major public health importance world-wide and the burden is heavier on the health-care infrastructure of countries in Sub-Saharan Africa. In Nigeria, RTI is the leading cause of trauma related morbidity and mortality. While there are some published epidemiological reports on RTI in the region, studies on the mechanism of causation of road traffic crashes (RTC) are not available. Over a 9-month period, we prospectively captured the 571 victims of RTC presenting to a single tertiary health care center in Nigeria. Data collected include demographic data, Mechanism of causation of RTC, Injuries sustained and outcomes. Over three-quarters of the victims are young people and half were either traders (27.5%) or students (20%). Pedestrians, motorcycle riders and open truck occupants (people sitting at the rear loading compartment of trucks) often had fatal injuries. Analysis of collision patterns showed that lone crashes were the most frequent though car-to-motorcycle crashes caused a quarter of the deaths. Host factors (over-speeding driver, driver misjudgment, sleeping driver etc.) were responsible for four-fifths of the crashes while vehicular and environmental factors accounted for the remaining. On binary regression analysis, head injured victims had higher odds of dying than the non-head injured (Odds ratio = 6.5). This paper elucidates the mechanisms of causation of and types of injuries sustained following RTC in Nigeria and thus provide opportunities for prevention and control of this unacceptable situation.

Host, vehicular and environmental factors responsible for road traffic crashes in a nigerian city: identifiable issues for road traffic injury control

PubMed Central

Adeoye, Peter Oladapo; Kadri, Dotun Musiliu; Bello, Jibril Oyekunle; Ofoegbu, Chima Kingsley Pascal; Abdur-Rahman, Lukman Olajide; Adekanye, Adedeji Olugbenga; Solagberu, Babatunde Akeeb

2014-01-01

Introduction Road traffic injury (RTI) has assumed major public health importance world-wide and the burden is heavier on the health-care infrastructure of countries in Sub-Saharan Africa. In Nigeria, RTI is the leading cause of trauma related morbidity and mortality. While there are some published epidemiological reports on RTI in the region, studies on the mechanism of causation of road traffic crashes (RTC) are not available. Methods Over a 9-month period, we prospectively captured the 571 victims of RTC presenting to a single tertiary health care center in Nigeria. Data collected include demographic data, Mechanism of causation of RTC, Injuries sustained and outcomes. Results Over three-quarters of the victims are young people and half were either traders (27.5%) or students (20%). Pedestrians, motorcycle riders and open truck occupants (people sitting at the rear loading compartment of trucks) often had fatal injuries. Analysis of collision patterns showed that lone crashes were the most frequent though car-to-motorcycle crashes caused a quarter of the deaths. Host factors (over-speeding driver, driver misjudgment, sleeping driver etc.) were responsible for four-fifths of the crashes while vehicular and environmental factors accounted for the remaining. On binary regression analysis, head injured victims had higher odds of dying than the non-head injured (Odds ratio = 6.5). Conclusion This paper elucidates the mechanisms of causation of and types of injuries sustained following RTC in Nigeria and thus provide opportunities for prevention and control of this unacceptable situation. PMID:25780490

Climatology of successive equatorial plasma bubbles observed by GPS ROTI over Malaysia

NASA Astrophysics Data System (ADS)

Buhari, S. M.; Abdullah, M.; Yokoyama, T.; Otsuka, Y.; Nishioka, M.; Hasbi, A. M.; Bahari, S. A.; Tsugawa, T.

2017-02-01

The occurrence rate of the equatorial plasma bubble (EPB) with season, solar activity, and geomagnetic conditions are investigated using long-term data sets of Malaysia Real-Time Kinematics Network (MyRTKnet) from 2008 to 2013. The rate of TEC (total electron content) change index (ROTI) in 5 min was derived from MyRTKnet data to detect the EPB with scale sizes around tens of kilometers. Then, the daily east-west cross sections of 2-D ROTI maps were used to examine the EPB features over 100°E-119°E longitudes. The EPBs tend to occur successively in one night along the observational coverage of MyRTKnet during equinoxes in high solar activity years. The perturbations in a form of wavelike structures along the observed longitudes might be responsible for the development of successive EPBs due to high growth rate of the Rayleigh-Taylor instability (RTI) process. On the contrary, the occurrence of successive EPBs is infrequent and the occurrence day of EPB remains active during equinoctial months in low solar activity years. The small growth rate of the RTI process during low solar activity years might require a strong seed perturbation to generate the EPB structure. The occurrence probability of the EPB was found to be similar during quiet and disturbed geomagnetic conditions. The results imply that the strong perturbations play an important role in the development of the EPB in low solar activity years. Nonetheless, the high growth rate of the RTI could cause the successive occurrence of the EPB in high solar activity years.

Integration of genomic information into sport horse breeding programs for optimization of accuracy of selection.

PubMed

Haberland, A M; König von Borstel, U; Simianer, H; König, S

2012-09-01

Reliable selection criteria are required for young riding horses to increase genetic gain by increasing accuracy of selection and decreasing generation intervals. In this study, selection strategies incorporating genomic breeding values (GEBVs) were evaluated. Relevant stages of selection in sport horse breeding programs were analyzed by applying selection index theory. Results in terms of accuracies of indices (r(TI) ) and relative selection response indicated that information on single nucleotide polymorphism (SNP) genotypes considerably increases the accuracy of breeding values estimated for young horses without own or progeny performance. In a first scenario, the correlation between the breeding value estimated from the SNP genotype and the true breeding value (= accuracy of GEBV) was fixed to a relatively low value of r(mg) = 0.5. For a low heritability trait (h(2) = 0.15), and an index for a young horse based only on information from both parents, additional genomic information doubles r(TI) from 0.27 to 0.54. Including the conventional information source 'own performance' into the before mentioned index, additional SNP information increases r(TI) by 40%. Thus, particularly with regard to traits of low heritability, genomic information can provide a tool for well-founded selection decisions early in life. In a further approach, different sources of breeding values (e.g. GEBV and estimated breeding values (EBVs) from different countries) were combined into an overall index when altering accuracies of EBVs and correlations between traits. In summary, we showed that genomic selection strategies have the potential to contribute to a substantial reduction in generation intervals in horse breeding programs.

ENVIRONMENTAL TECHNOLOGY VERIFICATION: ADD-ON NOX CONTROLS

EPA Science Inventory

The paper discusses the environmental technology verification (ETV) of add-on nitrogen oxide (NOx) controls. Research Triangle Institute (RTI) is EPA's cooperating partner for the Air Pollution Control Technology (APCT) Program, one of a dozen ETV pilot programs. Verification of ...

eCDL integration with commercial skills test information system (CSTIMS)

DOT National Transportation Integrated Search

2012-11-30

In coordination with the West Virginia Division of Motor Vehicles (WVDMV), the Rahall Transportation Institute (RTI) integrated the eCDL program with the CSTIMS, a software program owned by the American Motor Vehicles Administrators Association (AAMV...

From menarche to menopause: A population-based assessment of water, sanitation, and hygiene risk factors for reproductive tract infection symptoms over life stages in rural girls and women in India

PubMed Central

Padhi, Bijaya; Torondel, Belen; Das, Padmalaya; Dutta, Ambarish; Sahoo, Krushna Chandra; Freeman, Matthew C.; Sager, Lauren; Panigrahi, Pinaki

2017-01-01

Women face greater challenges than men in accessing water, sanitation, and hygiene (WASH) resources to address their daily needs, and may respond to these challenges by adopting unsafe practices that increase the risk of reproductive tract infections (RTIs). WASH practices may change as women transition through socially-defined life stage experiences, like marriage and pregnancy. Thus, the relationship between WASH practices and RTIs might vary across female reproductive life stages. This cross-sectional study assessed the relationship between WASH exposures and self-reported RTI symptoms in 3,952 girls and women from two rural districts in India, and tested whether social exposures represented by reproductive life stage was an effect modifier of associations. In fully adjusted models, RTI symptoms were less common in women using a latrine without water for defecation versus open defecation (Odds Ratio (OR) = 0.69; Confidence Interval (CI) = 0.48, 0.98) and those walking shorter distances to a bathing location (OR = 0.79, CI = 0.63, 0.99), but there was no association between using a latrine with a water source and RTIs versus open defecation (OR = 1.09; CI = 0.69, 1.72). Unexpectedly, RTI symptoms were more common for women bathing daily with soap (OR = 6.55, CI = 3.60, 11.94) and for women washing their hands after defecation with soap (OR = 10.27; CI = 5.53, 19.08) or ash/soil/mud (OR = 6.02; CI = 3.07, 11.77) versus water only or no hand washing. WASH practices of girls and women varied across reproductive life stages, but the associations between WASH practices and RTI symptoms were not moderated by or confounded by life stage status. This study provides new evidence that WASH access and practices are associated with self-reported reproductive tract infection symptoms in rural Indian girls and women from different reproductive life stages. However, the counterintuitive directions of effect for soap use highlights that causality and mechanisms of effect cannot be inferred from this study design. Future research is needed to understand whether improvements in water and sanitation access could improve the practice of safe hygiene behaviors and reduce the global burden of RTIs in women. PMID:29206842

Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial.

PubMed

Bacharier, Leonard B; Guilbert, Theresa W; Mauger, David T; Boehmer, Susan; Beigelman, Avraham; Fitzpatrick, Anne M; Jackson, Daniel J; Baxi, Sachin N; Benson, Mindy; Burnham, Carey-Ann D; Cabana, Michael; Castro, Mario; Chmiel, James F; Covar, Ronina; Daines, Michael; Gaffin, Jonathan M; Gentile, Deborah Ann; Holguin, Fernando; Israel, Elliot; Kelly, H William; Lazarus, Stephen C; Lemanske, Robert F; Ly, Ngoc; Meade, Kelley; Morgan, Wayne; Moy, James; Olin, Tod; Peters, Stephen P; Phipatanakul, Wanda; Pongracic, Jacqueline A; Raissy, Hengameh H; Ross, Kristie; Sheehan, William J; Sorkness, Christine; Szefler, Stanley J; Teague, W Gerald; Thyne, Shannon; Martinez, Fernando D

2015-11-17

Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to illness pathogenesis. Strategies that effectively attenuate such episodes are needed. To evaluate if early administration of azithromycin, started prior to the onset of severe LRTI symptoms, in preschool children with recurrent severe LRTIs can prevent the progression of these episodes. A randomized, double-blind, placebo-controlled, parallel-group trial conducted across 9 academic US medical centers in the National Heart, Lung, and Blood Institute's AsthmaNet network, with enrollment starting in April 2011 and follow-up complete by December 2014. Participants were 607 children aged 12 through 71 months with histories of recurrent, severe LRTIs and minimal day-to-day impairment. Participants were randomly assigned to receive azithromycin (12 mg/kg/d for 5 days; n = 307) or matching placebo (n = 300), started early during each predefined RTI (child's signs or symptoms prior to development of LRTI), based on individualized action plans, over a 12- through 18-month period. The primary outcome measure was the number of RTIs not progressing to a severe LRTI, measured at the level of the RTI, that would in clinical practice trigger the prescription of oral corticosteroids. Presence of azithromycin-resistant organisms in oropharyngeal samples, along with adverse events, were among the secondary outcome measures. A total of 937 treated RTIs (azithromycin group, 473; placebo group, 464) were experienced by 443 children (azithromycin group, 223; placebo group, 220), including 92 severe LRTIs (azithromycin group, 35; placebo group, 57). Azithromycin significantly reduced the risk of progressing to severe LRTI relative to placebo (hazard ratio, 0.64 [95% CI, 0.41-0.98], P = .04; absolute risk for first RTI: 0.05 for azithromycin, 0.08 for placebo; risk difference, 0.03 [95% CI, 0.00-0.06]). Induction of azithromycin-resistant organisms and adverse events were infrequently observed. Among young children with histories of recurrent severe LRTIs, the use of azithromycin early during an apparent RTI compared with placebo reduced the likelihood of severe LRTI. More information is needed on the development of antibiotic-resistant pathogens with this strategy. clinicaltrials.gov Identifier: NCT01272635.

Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses

PubMed Central

Mauger, David T.; Boehmer, Susan; Beigelman, Avraham; Fitzpatrick, Anne M.; Jackson, Daniel J.; Baxi, Sachin N.; Benson, Mindy; Burnham, Carey-Ann D.; Cabana, Michael; Castro, Mario; Chmiel, James F.; Covar, Ronina; Daines, Michael; Gaffin, Jonathan M.; Gentile, Deborah Ann; Holguin, Fernando; Israel, Elliot; Kelly, H. William; Lazarus, Stephen C.; Lemanske, Robert F.; Ly, Ngoc; Meade, Kelley; Morgan, Wayne; Moy, James; Olin, Tod; Peters, Stephen P.; Phipatanakul, Wanda; Pongracic, Jacqueline A.; Raissy, Hengameh H.; Ross, Kristie; Sheehan, William J.; Sorkness, Christine; Szefler, Stanley J.; Teague, W. Gerald; Thyne, Shannon; Martinez, Fernando D.

2016-01-01

IMPORTANCE Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to illness pathogenesis. Strategies that effectively attenuate such episodes are needed. OBJECTIVE To evaluate if early administration of azithromycin, started prior to the onset of severe LRTI symptoms, in preschool children with recurrent severe LRTIs can prevent the progression of these episodes. DESIGN, SETTING, AND PARTICIPANTS A randomized, double-blind, placebo-controlled, parallel-group trial conducted across 9 academic US medical centers in the National Heart, Lung, and Blood Institute’s AsthmaNet network, with enrollment starting in April 2011 and follow-up complete by December 2014. Participants were 607 children aged 12 through 71 months with histories of recurrent, severe LRTIs and minimal day-to-day impairment. INTERVENTION Participants were randomly assigned to receive azithromycin (12 mg/kg/d for 5 days; n = 307) or matching placebo (n = 300), started early during each predefined RTI (child’s signs or symptoms prior to development of LRTI), based on individualized action plans, over a 12-through 18-month period. MAIN OUTCOMES AND MEASURES The primary outcome measure was the number of RTIs not progressing to a severe LRTI, measured at the level of the RTI, that would in clinical practice trigger the prescription of oral corticosteroids. Presence of azithromycin-resistant organisms in oropharyngeal samples, along with adverse events, were among the secondary outcome measures. RESULTS A total of 937 treated RTIs (azithromycin group, 473; placebo group, 464) were experienced by 443 children (azithromycin group, 223; placebo group, 220), including 92 severe LRTIs (azithromycin group, 35; placebo group, 57). Azithromycin significantly reduced the risk of progressing to severe LRTI relative to placebo (hazard ratio, 0.64 [95% CI, 0.41-0.98], P = .04; absolute risk for first RTI: 0.05 for azithromycin, 0.08 for placebo; risk difference, 0.03 [95% CI, 0.00-0.06]). Induction of azithromycin-resistant organisms and adverse events were infrequently observed. CONCLUSIONS AND RELEVANCE Among young children with histories of recurrent severe LRTIs, the use of azithromycin early during an apparent RTI compared with placebo reduced the likelihood of severe LRTI. More information is needed on the development of antibiotic-resistant pathogens with this strategy. PMID:26575060

Numerical models of diapiric structures: comparison of the 2D finite deformation field between Rayleigh-Taylor like and down-built like diapirs

NASA Astrophysics Data System (ADS)

Fuchs, Lukas; Schmeling, Harro; Koyi, Hemin

2013-04-01

Magmatic and salt diapirs are common structures in different tectonic regimes. Salt diapirs can act as possible hydrocarbon traps and, moreover, they could be used as repositories for nuclear waste disposal. Understanding the evolution and the dynamics of diapirs as well as their driving mechanisms has fundamental and applied significance. In general, salt diapirs seem to be driven by differential loading of sediments creating an uneven load that drives the salt from high to low pressure areas, e.g. a down-built diapir. Magmatic diapirs, instead, seem to be driven by buoyancy where lighter material rises vertically through a heavier overburden, i.e. a classical Rayleigh-Taylor instability [RTI]. These different driving mechanisms and dynamics strongly govern the internal deformation of the diapirs. In this study, we use a two-dimensional finite difference code (FDCON) in combination with a marker and cell method to calculate the finite deformation within diapiric structures. Thereby, we distinguish between the two different driving mechanisms, i.e. the differential loading and the buoyancy. We calculate the different finite deformation patterns during the evolution of RTI's and down-built diapirs for different viscosity ratios m = -?buoyant- ?overburden. The deformation pattern in the buoyant layer shows similarities for both diapiric structures, like high shear deformation at the bottom, a high finite deformation within the middle of the stem, and an increasing maximum finite deformation for a decreasing m. However, the strain partitioning between the overburden and the source layer is different within down-built diapirs compared to the RTI's, even for down-built diapirs with m = 1. Thus a higher amount of the total strain induced by down-building is concentrated within the buoyant layer. Moreover, in the case of viscosity ratios of m = 0.1 or 1 the sinking overburden units create an internal rotation within the diapiric bulb. This rotation depends indirectly on the sedimentation rate as it determines the width of the sediment basin; the higher the sedimentation rate, the wider the basins and the weaker the internal rotation. In addition, the viscous drag between the sinking overburden and the rising diapir creates a stronger and wider band of finite deformation along the edges of the down-built diapir in comparison to the RTI.

HIV lipodystrophy in participants randomised to lopinavir/ritonavir (LPV/r) +2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTI) or LPV/r + raltegravir as second-line antiretroviral therapy.

PubMed

Martin, Allison; Moore, Cecilia L; Mallon, Patrick W G; Hoy, Jennifer F; Emery, Sean; Belloso, Waldo H; Phanuphak, Praphan; Ferret, Samuel; Cooper, David A; Boyd, Mark A

2013-01-01

To compare changes over 48 weeks in body fat, lipids, Metabolic Syndrome and cardiovascular disease risk between patients randomised 1:1 to lopinavir/ritonavir (r/LPV) plus raltegravir (RAL) compared to r/LPV plus 2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) as second-line therapy. Participants were HIV-1 positive (>16 years) failing first-line treatment (2 consecutive HIV RNA >500 copies/mL) of NNRTI +2N(t)RTI. Whole body dual energy x-ray absorptiometry was performed at baseline and week 48. Data were obtained to calculate the Metabolic Syndrome and Framingham cardiovascular disease (CVD) risk score. Linear regression was used to compare mean differences between arms. Logistic regression compared incidence of metabolic syndrome. Associations between percent limb fat changes at 48 weeks with baseline variables were assessed by backward stepwise multivariate linear regression. Analyses were adjusted for gender, body mass index and smoking status. 210 participants were randomised. The mean (95% CI) increase in limb fat over 48 weeks was 15.7% (5.3, 25.9) or 0.9 kg (0.2, 1.5) in the r/LPV+N(t)RTI arm and 21.1% (11.1, 31,1) or 1.3 kg (0.7, 1.9) in the r/LPV+RAL arm, with no significant difference between treatment arms (-5.4% [-0.4 kg], p>0.1). Increases in total body fat mass (kg) and trunk fat mass (kg) were also similar between groups. Total:HDL cholesterol ratio was significantly higher in the RAL arm (mean difference -0.4 (1.4); p = 0.03), there were no other differences in lipid parameters between treatment arms. There were no statistically significant differences in CVD risk or incidence of Metabolic Syndrome between the two treatment arms. The baseline predictors of increased limb fat were high viral load, high insulin and participant's not taking lipid lowering treatment. In patients switching to second line therapy, r/LPV combined with RAL demonstrated similar improvements in limb fat as an N(t)RTI + r/LPV regimen, but a worse total:HDL cholesterol ratio over 48 weeks. This clinical trial is registered on Clinicaltrials.gov, registry number NCT00931463 http://clinicaltrials.gov/ ct2/show/NCT00931463?term = NCT00931463&rank = 1.

From menarche to menopause: A population-based assessment of water, sanitation, and hygiene risk factors for reproductive tract infection symptoms over life stages in rural girls and women in India.

PubMed

Baker, Kelly K; Padhi, Bijaya; Torondel, Belen; Das, Padmalaya; Dutta, Ambarish; Sahoo, Krushna Chandra; Das, Bhabani; Dreibelbis, Robert; Caruso, Bethany; Freeman, Matthew C; Sager, Lauren; Panigrahi, Pinaki

2017-01-01

Women face greater challenges than men in accessing water, sanitation, and hygiene (WASH) resources to address their daily needs, and may respond to these challenges by adopting unsafe practices that increase the risk of reproductive tract infections (RTIs). WASH practices may change as women transition through socially-defined life stage experiences, like marriage and pregnancy. Thus, the relationship between WASH practices and RTIs might vary across female reproductive life stages. This cross-sectional study assessed the relationship between WASH exposures and self-reported RTI symptoms in 3,952 girls and women from two rural districts in India, and tested whether social exposures represented by reproductive life stage was an effect modifier of associations. In fully adjusted models, RTI symptoms were less common in women using a latrine without water for defecation versus open defecation (Odds Ratio (OR) = 0.69; Confidence Interval (CI) = 0.48, 0.98) and those walking shorter distances to a bathing location (OR = 0.79, CI = 0.63, 0.99), but there was no association between using a latrine with a water source and RTIs versus open defecation (OR = 1.09; CI = 0.69, 1.72). Unexpectedly, RTI symptoms were more common for women bathing daily with soap (OR = 6.55, CI = 3.60, 11.94) and for women washing their hands after defecation with soap (OR = 10.27; CI = 5.53, 19.08) or ash/soil/mud (OR = 6.02; CI = 3.07, 11.77) versus water only or no hand washing. WASH practices of girls and women varied across reproductive life stages, but the associations between WASH practices and RTI symptoms were not moderated by or confounded by life stage status. This study provides new evidence that WASH access and practices are associated with self-reported reproductive tract infection symptoms in rural Indian girls and women from different reproductive life stages. However, the counterintuitive directions of effect for soap use highlights that causality and mechanisms of effect cannot be inferred from this study design. Future research is needed to understand whether improvements in water and sanitation access could improve the practice of safe hygiene behaviors and reduce the global burden of RTIs in women.

Methamphetamine-induced neurotoxicity is attenuated in transgenic mice with a null mutation for interleukin-6.

PubMed

Ladenheim, B; Krasnova, I N; Deng, X; Oyler, J M; Polettini, A; Moran, T H; Huestis, M A; Cadet, J L

2000-12-01

Increasing evidence implicates apoptosis as a major mechanism of cell death in methamphetamine (METH) neurotoxicity. The involvement of a neuroimmune component in apoptotic cell death after injury or chemical damage suggests that cytokines may play a role in METH effects. In the present study, we examined if the absence of IL-6 in knockout (IL-6-/-) mice could provide protection against METH-induced neurotoxicity. Administration of METH resulted in a significant reduction of [(125)I]RTI-121-labeled dopamine transporters in the caudate-putamen (CPu) and cortex as well as depletion of dopamine in the CPu and frontal cortex of wild-type mice. However, these METH-induced effects were significantly attenuated in IL-6-/- animals. METH also caused a decrease in serotonin levels in the CPu and hippocampus of wild-type mice, but no reduction was observed in IL-6-/- animals. Moreover, METH induced decreases in [(125)I]RTI-55-labeled serotonin transporters in the hippocampal CA3 region and in the substantia nigra-reticulata but increases in serotonin transporters in the CPu and cingulate cortex in wild-type animals, all of which were attenuated in IL-6-/- mice. Additionally, METH caused increased gliosis in the CPu and cortices of wild-type mice as measured by [(3)H]PK-11195 binding; this gliotic response was almost completely inhibited in IL-6-/- animals. There was also significant protection against METH-induced DNA fragmentation, measured by the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeled (TUNEL) cells in the cortices. The protective effects against METH toxicity observed in the IL-6-/- mice were not caused by differences in temperature elevation or in METH accumulation in wild-type and mutant animals. Therefore, these observations support the proposition that IL-6 may play an important role in the neurotoxicity of METH.

ENVIRONMENTAL TECHNOLOGY VERIFICATION AND INDOOR AIR

EPA Science Inventory

The paper discusses environmental technology verification and indoor air. RTI has responsibility for a pilot program for indoor air products as part of the U.S. EPA's Environmental Technology Verification (ETV) program. The program objective is to further the development of sel...

VERIFICATION TESTING OF TECHNOLOGIES TO CLEAN OR FILTER VENTILATION AIR

EPA Science Inventory

Because of the importance of indoor air quality, Research Triangle Institute's Air Pollution Control Technology is adding indoor air products as a new technology category available for testing. This paper discusses RTI's participation in previous Environmental Technology Verifica...

Does antioxidant properties of the main component of essential oil reflect its antioxidant properties? The comparison of antioxidant properties of essential oils and their main components.

PubMed

Dawidowicz, Andrzej L; Olszowy, Małgorzata

2014-01-01

This study discusses the similarities and differences between the antioxidant activities of some essential oils: thyme (Thymus vulgaris), basil (Ocimum basilicum), peppermint (Mentha piperita), clove (Caryophyllus aromaticus), summer savory (Satureja hortensis), sage (Salvia hispanica) and lemon (Citrus limon (L.) Burm.) and of their main components (thymol or estragole or menthol or eugenol or carvacrol or camphor or limonene) estimated by using 2,2'-Diphenyl-1-picrylhydrazyl, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt and β-carotene bleaching assays. The obtained data show that the antioxidant properties of essential oil do not always depend on the antioxidant activity of its main component, and that they can be modulated by their other components. The conclusions concerning the interaction of essential oil components depend on the type of method applied for assessing the antioxidant activity. When comparing the antioxidant properties of essential oils and their main components, the concepts of synergism, antagonism and additivity are very relevant.

[Extraction and analysis of chemical components of essential oil in Thymus vulgaris of tissue culture].

PubMed

Li, Xiao-Dong; Yang, Li; Xu, Shi-Qian; Li, Jian-Guo; Cheng, Zhi-Hui; Dang, Jian-Zhang

2011-10-01

To extract the essential oils from the Seedlings, the Aseptic Seedlings and the Tissue Culture Seedlings of Thymus vulgaris and analyze their chemical components and the relative contents. The essential oils were extracted by steam distillation, the chemical components and the relative contents were identified and analyzed by gas chromatography-mass spectrometry (GC/MS) and peak area normalization method. The main chemical components of essential oil in these three samples had no significant difference, they all contained the main components of essential oil in Thymus vulgaris: Thymol, Carvacrol, o-Cymene, gamma-Terpinene, Caryophyllene et al. and only had a slight difference in the relative content. This study provides important theoretical foundation and data reference for further study on production of essential oil in thyme by tissue culture technology.

TESTING INDOOR AIR PRODUCTS: ONE APPROACH TO DEVELOPING WIDELY ACCEPTED PROTOCOLS

EPA Science Inventory

The paper describes an approach to developing widely acce ted products for testing indoor air products. [NOTE: Research Triangle Institute (RTI) is a partner in the U.S. Environmental Protection Agency's (EPA's) Environmental Technology Verification (ETV) Program with responsibil...

Method Analysis of Microbial-Resistant Gypsum Products

EPA Science Inventory

Method Analysis of Microbial-Resistant Gypsum ProductsD.A. Betancourt1, T.R.Dean1, A. Evans2, and G.Byfield2 1. US Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory; RTP, NC 277112. RTI International, RTP, NCSeveral...

ENVIRONMENTAL TECHNOLOGY VERIFICATION--GENERIC VERIFICATION PROTOCOL FOR BIOLOGICAL AND AEROSOL TESTING OF GENERAL VENTILATION AIR CLEANERS

EPA Science Inventory

Under EPA's Environmental Technology Verification Program, Research Triangle Institute (RTI) will operate the Air Pollution Control Technology Center to verify the filtration efficiency and bioaerosol inactivation efficiency of heating, ventilation and air conditioning air cleane...

Characterization of Lone Pine, California, tremolite asbestos and preparation of research material

USGS Publications Warehouse

Harper, Martin; Van Gosen, Bradley S.; Crankshaw, Owen S; Doorn, Stacy S; Ennis, J. Todd; Harrison, Sara E

2014-01-01

Well-characterized amphibole asbestos mineral samples are required for use as analytical standards and in future research projects. Currently, the National Institute for Standards and Technology Standard Reference Material samples of asbestos are listed as ‘Discontinued’. The National Institute for Occupational Safety and Health (NIOSH) has a goal under the Asbestos Roadmap of locating and characterizing research materials for future use. Where an initial characterization analysis determines that a collected material is appropriate for use as a research material in terms of composition and asbestiform habit, sufficient amounts of the material will be collected to make it publicly available. An abandoned mine near Lone Pine, California, contains a vein of tremolite asbestos, which was the probable source of a reference material that has been available for the past 17 years from the Health and Safety Laboratory (HSL) in the UK. Newly collected fibrous vein material from this mine was analyzed at Research Triangle Institute (RTI International) with some additional analysis by the US Geological Survey’s Denver Microbeam Laboratory. The analysis at RTI International included: (i) polarized light microscopy (PLM) with a determination of principal optical properties; (ii) X-ray diffraction; (iii) transmission electron microscopy, including energy dispersive X-ray spectroscopy and selected-area electron diffraction; and (iv) spindle stage analysis using PLM to determine whether individual fibers and bundles of the samples were polycrystalline or single-crystal cleavage fragments. The overall findings of the study indicated that the material is tremolite asbestos with characteristics substantially similar to the earlier distributed HSL reference material. A larger quantity of material was prepared by sorting, acid-washing and mixing for sub-division into vials of ~10g each. These vials have been transferred from NIOSH to RTI International, from where they can be obtained on request.

Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-Saharan Africa: a cross-sectional study.

PubMed

Jespers, Vicky; Crucitti, Tania; Menten, Joris; Verhelst, Rita; Mwaura, Mary; Mandaliya, Kishor; Ndayisaba, Gilles F; Delany-Moretlwe, Sinead; Verstraelen, Hans; Hardy, Liselotte; Buvé, Anne; van de Wijgert, Janneke

2014-01-01

Clinical development of vaginally applied products aimed at reducing the transmission of HIV and other sexually transmitted infections, has highlighted the need for a better characterisation of the vaginal environment. We set out to characterise the vaginal environment in women in different settings in sub-Saharan Africa. A longitudinal study was conducted in Kenya, Rwanda and South-Africa. Women were recruited into pre-defined study groups including adult, non-pregnant, HIV-negative women; pregnant women; adolescent girls; HIV-negative women engaging in vaginal practices; female sex workers; and HIV-positive women. Consenting women were interviewed and underwent a pelvic exam. Samples of vaginal fluid and a blood sample were taken and tested for bacterial vaginosis (BV), HIV and other reproductive tract infections (RTIs). This paper presents the cross-sectional analyses of BV Nugent scores and RTI prevalence and correlates at the screening and the enrolment visit. At the screening visit 38% of women had BV defined as a Nugent score of 7-10, and 64% had more than one RTI (N. gonorrhoea, C. trachomatis, T. vaginalis, syphilis) and/or Candida. At screening the likelihood of BV was lower in women using progestin-only contraception and higher in women with more than one RTI. At enrolment, BV scores were significantly associated with the presence of prostate specific antigen (PSA) in the vaginal fluid and with being a self-acknowledged sex worker. Further, sex workers were more likely to have incident BV by Nugent score at enrolment. Our study confirmed some of the correlates of BV that have been previously reported but the most salient finding was the association between BV and the presence of PSA in the vaginal fluid which is suggestive of recent unprotected sexual intercourse.

Road traffic incidents in Uganda: a systematic review study of a five-year trend.

PubMed

Balikuddembe, Joseph Kimuli; Ardalan, Ali; Khorasani-Zavareh, Davoud; Nejati, Amir; Munanura, Kasiima Stephen

2017-01-01

Over the years, Uganda has been one of the low and middle-income countries bearing the heaviest burden of road traffic incidents (RTI). Since the proclamation of the United Nations Decade of Action for Road Safety 2011 - 2020, a number of measures have been taken to reduce the burden. However, they ought to be premised on existing evidence-based research; therefore, the present review ventures to report the most recent five-year trend of RTI in Uganda. Based on Preferred Reporting Items for Systematic Reviews and Meta-Data Analysis (PRISMA) guidelines, a systematic review was employed. Using a thematic analysis, the articles were grouped into: trauma etiology, trauma care, mortality, cost, trauma registry and communication, intervention and treatment for final analysis. Of the nineteen articles that were identified to be relevant to the study, the etiology of RTI was inevitably observed to be an important cause of injuries in Uganda. The risk factors cut across: the crash type, injury physiology, cause, victims, setting, age, economic status, and gender. All studies that were reviewed have advanced varying recommendations aimed at responding to the trend of RTIs in Uganda, of which some are in tandem with the five pillars of the United Nations Decade of Action for Road Safety 2011 - 2020. Peripheral measures of the burden of RTIs in Uganda were undertaken within afive-year timeframe (2011-2015) of implementing the United Nations Decade of Action for Road Safety. The measures however, ought to be scaled-up on robust evidence based research available from all the concerned stakeholders beyond Kampala or central region to other parts of Uganda. © 2017 KUMS, All rights reserved.

Internal consistency and stability of the CANTAB neuropsychological test battery in children.

PubMed

Syväoja, Heidi J; Tammelin, Tuija H; Ahonen, Timo; Räsänen, Pekka; Tolvanen, Asko; Kankaanpää, Anna; Kantomaa, Marko T

2015-06-01

The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computer-assessed test battery widely use in different populations. The internal consistency and 1-year stability of CANTAB tests were examined in school-age children. Two hundred-thirty children (57% girls) from five schools in the Jyväskylä school district in Finland participated in the study in spring 2011. The children completed the following CANTAB tests: (a) visual memory (pattern recognition memory [PRM] and spatial recognition memory [SRM]), (b) executive function (spatial span [SSP], Stockings of Cambridge [SOC], and intra-extra dimensional set shift [IED]), and (c) attention (reaction time [RTI] and rapid visual information processing [RVP]). Seventy-four children participated in the follow-up measurements (64% girls) in spring 2012. Cronbach's alpha reliability coefficient was used to estimate the internal consistency of the nonhampering test, and structural equation models were applied to examine the stability of these tests. The reliability and the stability could not be determined for IED or SSP because of the nature of these tests. The internal consistency was acceptable only in the RTI task. The 1-year stability was moderate-to-good for the PRM, RTI, and RVP. The SSP and IED showed a moderate correlation between the two measurement points. The SRM and the SOC tasks were not reliable or stable measures in this study population. For research purposes, we recommend using structural equation modeling to improve reliability. The results suggest that the reliability and the stability of computer-based test batteries should be confirmed in the target population before using them for clinical or research purposes. (c) 2015 APA, all rights reserved).

What gives rise to clinician gut feeling, its influence on management decisions and its prognostic value for children with RTI in primary care: a prospective cohort study.

PubMed

Turnbull, Sophie; Lucas, Patricia J; Redmond, Niamh M; Christensen, Hannah; Thornton, Hannah; Cabral, Christie; Blair, Peter S; Delaney, Brendan C; Thompson, Matthew; Little, Paul; Peters, Tim J; Hay, Alastair D

2018-02-05

The objectives were to identify 1) the clinician and child characteristics associated with; 2) clinical management decisions following from, and; 3) the prognostic value of; a clinician's 'gut feeling something is wrong' for children presenting to primary care with acute cough and respiratory tract infection (RTI). Multicentre prospective cohort study where 518 primary care clinicians across 244 general practices in England assessed 8394 children aged ≥3 months and < 16 years for acute cough and RTI. The main outcome measures were: Self-reported clinician 'gut feeling'; clinician management decisions (antibiotic prescribing, referral for acute admission); and child's prognosis (reconsultation with evidence of illness deterioration, hospital admission in the 30 days following recruitment). Clinician years since qualification, parent reported symptoms (illness severity score ≥ 7/10, severe fever < 24 h, low energy, shortness of breath) and clinical examination findings (crackles/ crepitations on chest auscultation, recession, pallor, bronchial breathing, wheeze, temperature ≥ 37.8 °C, tachypnoea and inflamed pharynx) independently contributed towards a clinician 'gut feeling that something was wrong'. 'Gut feeling' was independently associated with increased antibiotic prescribing and referral for secondary care assessment. After adjustment for other associated factors, gut feeling was not associated with reconsultations or hospital admissions. Clinicians were more likely to report a gut feeling something is wrong, when they were more experienced or when children were more unwell. Gut feeling is independently and strongly associated with antibiotic prescribing and referral to secondary care, but not with two indicators of poor child health.

Comparison of Road Traffic Injury Characteristics between Local versus Floating Migrant Patients in a Tertiary Hospital between 2007 and 2010

PubMed Central

Xu, Chungui; Wang, Yanhua; Han, Na; Kou, Yuhui; Yin, Xiaofeng; Zhang, Peixun; Wang, Tianbing; Zhang, Dianying; Jiang, Baoguo

2014-01-01

Background The aim of this study is to give a description of the road traffic injuries (RTIs) characteristics of floating migrant population by comparing with those of local residents in a harbor city of China. Methods A population-based descriptive study was carried out between 2007 and 2010 with RTI patient records from the Fifth Center Hospital of Tianjin. Inpatient diagnoses of RTI patients were defined using the International Classification of Diseases, Tenth Revision (ICD-10) codes. We analyzed the demographics and general characteristics of RTI patients that were in the hospital during the four years. In order to compare the group differences between local resident patients and floating migrant patients, the distribution of their ages, diagnoses, severity of injuries, duration of inpatient stays, hospitalization cost were analyzed. Results People between the ages of 16 and 55 were the most likely to suffer RTIs. The floating migrant patients between the ages of 16 and 45 had a higher incidence of accidents, while local resident patients between 46 and 55 had a higher incidence of accidents. Compared to local resident patients, floating migrant patients were more vulnerable to open injuries and severe traffic injuries. With the severity of injuries ranked from mild to severe, floating migrant patients had lower duration of inpatient stay, but higher hospitalization costs compared to local resident patients. Conclusions Floating migrant patients had a different age distribution, severity of injuries, diseases, inpatient duration and hospitalization cost compared with local resident patients. Compared to local resident patients, floating migrants had a higher risk to RTIs and were more vulnerable to severer traffic accidents at lower ages. PMID:24475023

Treatment-seeking for symptoms of reproductive tract infections among young women in India.

PubMed

Sabarwal, Shagun; Santhya, K G

2012-06-01

Small proportions of Indian women report seeking treatment for symptoms suggestive of reproductive tract infections (RTIs). Most studies on treatment-seeking have focused broadly on women of reproductive age, and little is known about the experiences of adolescent girls and young women, particularly the unmarried. Data from 2,742 married and 2,108 unmarried women aged 15-24 who reported at least one symptom of an RTI in the past three months were drawn from a subnationally representative survey of youth in India in 2006-2008. Multivariate logistic regression analysis was conducted to identify associations between respondents' characteristics and treatment-seeking from a formal medical provider. In addition, among those who had used such providers, associations between characteristics and use of private rather than public providers were identified. About two-fifths of married and one-third of unmarried women had sought treatment from formal medical providers for their RTI symptoms. While married women's experience of intimate partner violence was negatively associated with seeking treatment from a formal provider (odds ratio, 0.8), their perceived access to sexual and reproductive health services and their awareness of STI symptoms were positively associated with such treatment (1.3-1.4). Both married and unmarried women were more likely to seek treatment from private than from public providers, and two indicators of women's autonomy were positively correlated with using private providers (1.6-2.8). Limited treatment-seeking for RTI symptoms by young women underscores the need to address power imbalances within marriage and to encourage health care providers to develop appropriate strategies to reach younger, as well as unmarried, women.

Road traffic incidents in Uganda: a systematic review of a five-year trend

PubMed Central

Balikuddembe, Joseph Kimuli; Ardalan, Ali; Khorasani-Zavareh, Davoud; Nejati, Amir; Munanura, Kasiima Stephen

2017-01-01

Abstract: Background: Over the years, Uganda has been one of the low and middle-income countries bearing the heaviest burden of road traffic incidents (RTI). Since the proclamation of the United Nations Decade of Action for Road Safety 2011 – 2020, a number of measures have been taken to reduce the burden. However, they ought to be premised on existing evidence-based research; therefore, the present review ventures to report the most recent five-year trend of RTI in Uganda. Methods: Based on Preferred Reporting Items for Systematic Reviews and Meta-Data Analysis (PRISMA) guidelines, a systematic review was employed. Using a thematic analysis, the articles were grouped into: trauma etiology, trauma care, mortality, cost, trauma registry and communication, intervention and treatment for final analysis. Results: Of the nineteen articles that were identified to be relevant to the study, the etiology of RTI was inevitably observed to be an important cause of injuries in Uganda. The risk factors cut across: the crash type, injury physiology, cause, victims, setting, age, economic status, and gender. All studies that were reviewed have advanced varying recommendations aimed at responding to the trend of RTIs in Uganda, of which some are in tandem with the five pillars of the United Nations Decade of Action for Road Safety 2011 – 2020. Conclusions: Peripheral measures of the burden of RTIs in Uganda were undertaken within a five-year timeframe (2011-2015) of implementing the United Nations Decade of Action for Road Safety. The measures however, ought to be scaled-up on robust evidence based research available from all the concerned stakeholders beyond Kampala or central region to other parts of Uganda. PMID:28039687

Characterization of Lone Pine, California, Tremolite Asbestos and Preparation of Research Material

PubMed Central

Harper, Martin; Van Gosen, Bradley; Crankshaw, Owen S.; Doorn, Stacy S.; Ennis, Todd J.; Harrison, Sara E.

2016-01-01

Well-characterized amphibole asbestos mineral samples are required for use as analytical standards and in future research projects. Currently, the National Institute for Standards and Technology Standard Reference Material samples of asbestos are listed as ‘Discontinued’. The National Institute for Occupational Safety and Health (NIOSH) has a goal under the Asbestos Roadmap of locating and characterizing research materials for future use. Where an initial characterization analysis determines that a collected material is appropriate for use as a research material in terms of composition and asbestiform habit, sufficient amounts of the material will be collected to make it publicly available. An abandoned mine near Lone Pine, California, contains a vein of tremolite asbestos, which was the probable source of a reference material that has been available for the past 17 years from the Health and Safety Laboratory (HSL) in the UK. Newly collected fibrous vein material from this mine was analyzed at Research Triangle Institute (RTI International) with some additional analysis by the US Geological Survey’s Denver Microbeam Laboratory. The analysis at RTI International included: (i) polarized light microscopy (PLM) with a determination of principal optical properties; (ii) X-ray diffraction; (iii) transmission electron microscopy, including energy dispersive X-ray spectroscopy and selected-area electron diffraction; and (iv) spindle stage analysis using PLM to determine whether individual fibers and bundles of the samples were polycrystalline or single-crystal cleavage fragments. The overall findings of the study indicated that the material is tremolite asbestos with characteristics substantially similar to the earlier distributed HSL reference material. A larger quantity of material was prepared by sorting, acid-washing and mixing for sub-division into vials of ~10 g each. These vials have been transferred from NIOSH to RTI International, from where they can be obtained on request. PMID:25268000

Accelerating chronically unresponsive children to tier 3 instruction: what level of data is necessary to ensure selection accuracy?

PubMed

Compton, Donald L; Gilbert, Jennifer K; Jenkins, Joseph R; Fuchs, Douglas; Fuchs, Lynn S; Cho, Eunsoo; Barquero, Laura A; Bouton, Bobette

2012-01-01

Response-to-intervention (RTI) approaches to disability identification are meant to put an end to the so-called wait-to-fail requirement associated with IQ discrepancy. However, in an unfortunate irony, there is a group of children who wait to fail in RTI frameworks. That is, they must fail both general classroom instruction (Tier 1) and small-group intervention (Tier 2) before becoming eligible for the most intensive intervention (Tier 3). The purpose of this article was to determine how to predict accurately which at-risk children will be unresponsive to Tiers 1 and 2, thereby allowing unresponsive children to move directly from Tier 1 to Tier 3. As part of an efficacy study of a multitier RTI approach to prevention and identification of reading disabilities (RD), 129 first-grade children who were unresponsive to classroom reading instruction were randomly assigned to 14 weeks of small-group, Tier 2 intervention. Nonresponders to this instruction (n = 33) were identified using local norms on first-grade word identification fluency growth linked to a distal outcome of RD at the end of second grade. Logistic regression models were used to predict membership in responder and nonresponder groups. Predictors were entered as blocks of data from least to most difficult to obtain: universal screening data, Tier 1 response data, norm referenced tests, and Tier 2 response data. Tier 2 response data were not necessary to classify students as responders and nonresponders to Tier 2 instruction, suggesting that some children can be accurately identified as eligible for Tier 3 intervention using only Tier 1 data, thereby avoiding prolonged periods of failure to instruction.

[Study on material basis of essential oil from Yin Teng Gu Bi Kang prescription on activating blood circulation].

PubMed

Wang, Yuan-Qing; Yan, Jian-Ye; Gong, Li-Min; Luo, Kun; Li, Shun-Xiang; Yang, Yan-Tao; Xie, Yu

2014-08-01

To explore the component difference of the serum containing essential oil from Yin Teng Gu Bi Kang prescription in pathologic and physiologic rat models, and to reveal the material basis of its efficacy of activating blood circulation. The essential oils were obtained by CO2 supercritical fluid extraction and the ingredients of the essential oils in vitro and in vivo (under physiological and pathological status) were analyzed by GC-MS to compare differences of the essential oil under physiological and pathological status in rats. 32 components were identified with the main components of Z-ligustilide (39.23%) and d-limonene (21.7%) in the essential oil. In vivo analysis on the essential oil indicated that 16 components were identified, 7 existed originally in essential oil and 9 were metabolites under physiological status; while 22 components were identified, 10 existed originally in essential oil and 12 were metabolites under pathological status (acute blood stasis). There were 7 common prototypes and 8 common metabolites under different physiological status. The absorption and metabolism of essential oils were affected by blood stasis and the compounds migrating to blood may be the effective substance in activating blood circulation.

Grading Exceptional and Struggling Learners

ERIC Educational Resources Information Center

Jung, Lee Ann; Guskey, Thomas R.

2011-01-01

How can you ensure that you are grading your exceptional students fairly? Teachers receive very little guidance for grading students with disabilities, English learners, and those receiving services through a response-to-intervention (RTI) process. This practitioner-friendly book provides teachers and administrators with an effective framework for…

Response to Intervention and Math Instruction

ERIC Educational Resources Information Center

Hinton, Vanessa; Flores, Margaret M.; Shippen, Margaret

2013-01-01

Response to intervention (RTI) is a framework in which interventions are implemented mostly in general education classes to resolve academic difficulties and help to mitigate contextual variables (i.e., lack of instruction, socio economic status, cultural differences, etc.) as an explanation for academic failure. The implementation of…

76 FR 77812 - Notice of Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... Practices for Elementary School Reading (School and Staff Practices). OMB Control Number: 1850--New. Agency.... Abstract: The Evaluation of Response to Intervention (RtI) Practices for Elementary School Reading will... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review AGENCY: Department of Education...

PARTICULATE ORGANIC CARBON MEASUREMENTS COLLECTED WITH LOW FLOW PERSONAL SAMPLERS

EPA Science Inventory

EPA's National Exposure Research Laboratory and the Research Triangle Institute (RTI) have conducted a particulate matter (PM) personal exposure study in Research Triangle Park, NC. Particulate carbon was sampled with pre-fired quartz filters using low flow PM2.5 samplers (2 L...

State and Substate Estimates of Nonmedical Use of Prescription Pain Relievers

MedlinePlus

... of NSDUH's strengths is the stability of its survey design, which allows for multiple years of data to ... 204,000 respondents aged 12 or older. The Survey collects data by administering ... in Research Triangle Park, North Carolina. (RTI International is a ...

Self-adaptive Fault-Tolerance of HLA-Based Simulations in the Grid Environment

NASA Astrophysics Data System (ADS)

Huang, Jijie; Chai, Xudong; Zhang, Lin; Li, Bo Hu

The objects of a HLA-based simulation can access model services to update their attributes. However, the grid server may be overloaded and refuse the model service to handle objects accesses. Because these objects have been accessed this model service during last simulation loop and their medium state are stored in this server, this may terminate the simulation. A fault-tolerance mechanism must be introduced into simulations. But the traditional fault-tolerance methods cannot meet the above needs because the transmission latency between a federate and the RTI in grid environment varies from several hundred milliseconds to several seconds. By adding model service URLs to the OMT and expanding the HLA services and model services with some interfaces, this paper proposes a self-adaptive fault-tolerance mechanism of simulations according to the characteristics of federates accessing model services. Benchmark experiments indicate that the expanded HLA/RTI can make simulations self-adaptively run in the grid environment.

Airborne Radar Interferometric Repeat-Pass Processing

NASA Technical Reports Server (NTRS)

Hensley, Scott; Michel, Thierry R.; Jones, Cathleen E.; Muellerschoen, Ronald J.; Chapman, Bruce D.; Fore, Alexander; Simard, Marc; Zebker, Howard A.

2011-01-01

Earth science research often requires crustal deformation measurements at a variety of time scales, from seconds to decades. Although satellites have been used for repeat-track interferometric (RTI) synthetic-aperture-radar (SAR) mapping for close to 20 years, RTI is much more difficult to implement from an airborne platform owing to the irregular trajectory of the aircraft compared with microwave imaging radar wavelengths. Two basic requirements for robust airborne repeat-pass radar interferometry include the ability to fly the platform to a desired trajectory within a narrow tube and the ability to have the radar beam pointed in a desired direction to a fraction of a beam width. Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) is equipped with a precision auto pilot developed by NASA Dryden that allows the platform, a Gulfstream III, to nominally fly within a 5 m diameter tube and with an electronically scanned antenna to position the radar beam to a fraction of a beam width based on INU (inertial navigation unit) attitude angle measurements.

Predicting reading outcomes with progress monitoring slopes among middle grade students

PubMed Central

Tolar, Tammy D.; Barth, Amy E.; Fletcher, Jack M.; Francis, David J.; Vaughn, Sharon

2013-01-01

Effective implementation of response-to-intervention (RTI) frameworks depends on efficient tools for monitoring progress. Evaluations of growth (i.e., slope) may be less efficient than evaluations of status at a single time point, especially if slopes do not add to predictions of outcomes over status. We examined progress monitoring slope validity for predicting reading outcomes among middle school students by evaluating latent growth models for different progress monitoring measure-outcome combinations. We used multi-group modeling to evaluate the effects of reading ability, reading intervention, and progress monitoring administration condition on slope validity. Slope validity was greatest when progress monitoring was aligned with the outcome (i.e., word reading fluency slope was used to predict fluency outcomes in contrast to comprehension outcomes), but effects varied across administration conditions (viz., repeated reading of familiar vs. novel passages). Unless the progress monitoring measure is highly aligned with outcome, slope may be an inefficient method for evaluating progress in an RTI context. PMID:24659899

Effectiveness of a 10-week tier-1 response to intervention program in improving fine motor and visual-motor skills in general education kindergarten students.

PubMed

Ohl, Alisha M; Graze, Hollie; Weber, Karen; Kenny, Sabrina; Salvatore, Christie; Wagreich, Sarah

2013-01-01

This study examined the efficacy of a 10-wk Tier 1 Response to Intervention (RtI) program developed in collaboration with classroom teachers to improve the fine motor and visual-motor skills of general education kindergarten students. We recruited 113 students in six elementary schools. Two general education kindergarten classrooms at each school participated in the study. Classrooms were randomly assigned to the intervention and control groups. Fine motor skills, pencil grip, and visual-motor integration were measured at the beginning of the school year and after the 10-wk intervention. The intervention group demonstrated a statistically significant increase in fine motor and visual-motor skills, whereas the control group demonstrated a slight decline in both areas. Neither group demonstrated a change in pencil grip. This study provides preliminary evidence that a Tier 1 RtI program can improve fine motor and visual-motor skills in kindergarten students. Copyright © 2013 by the American Occupational Therapy Association, Inc.

Construct and concurrent validity of the Cambridge neuropsychological automated tests in Portuguese older adults without neuropsychiatric diagnoses and with Alzheimer's disease dementia.

PubMed

Matos Gonçalves, Marta; Pinho, Maria Salomé; Simões, Mário R

2018-03-01

We aimed to analyze the construct and concurrent validity of the Rapid Visual Information Processing (RVP), Paired Associates Learning (PAL), Reaction Time (RTI), and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB®). Inclusion criteria were checked in a first session. The CANTAB and additional pencil-and-paper tests were administered within 1 week. The participants (aged 69-96 years) were 137 Portuguese adults without neuropsychiatric diagnoses and 37 adults with mild-to-moderate Alzheimer's disease dementia. Comparisons were made between the CANTAB tests and between these tests and the Rey Complex Figure Test (RCFT), Verbal Fluency (VF) test, and some Wechsler Memory Scale-III and Wechsler Adult Intelligence Scale-III subtests. Most intra-test correlations were stronger than the CANTAB inter-test correlations. The RVP correlated more with VF animals (.44), the PAL with RCFT immediate recall (-.52), the RTI with RVP mean latency (.42), and the SWM with Spatial Span backward (-.39).

Experimental evidence of a bubble-merger regime for the Rayleigh-Taylor Instability at the ablation front

NASA Astrophysics Data System (ADS)

Casner, A.; Liberatore, S.; Masse, L.; Martinez, D.; Haan, S. W.; Kane, J.; Moore, A. S.; Seugling, R.; Farrell, M.; Giraldez, E.; Nikroo, A.; Smalyuk, V. A.; Remington, B. A.

2016-05-01

Under the Discovery Science program, the longer pulses and higher laser energies provided by the National Ignition Facility (NIF) have been harnessed to study, first time in indirect-drive, the highly nonlinear stage of the Rayleigh-Taylor Instability (RTI) at the ablation front. A planar plastic package with pre-imposed two-dimensional broadband modulations is accelerated for up to 12 ns by the x-ray drive of a gas-filled gold radiation cavity with a radiative temperature plateau at 175 eV. This extended tailored drive allows a distance traveled in excess of 1 mm for a 130 μm thick foil, a factor 3x larger than previously achieved on other laser facilities. As a consequence, we have measured the ablative RTI in transition from the weakly nonlinear stage up to the deep nonlinear stage for various initial conditions. A bubble merger regime has been observed and the ablative stabilization strength varied by changing the plastic dopant from iodine to germanium.

Multiple eigenmodes of the Rayleigh-Taylor instability observed for a fluid interface with smoothly varying density

NASA Astrophysics Data System (ADS)

Yu, C. X.; Xue, C.; Liu, J.; Hu, X. Y.; Liu, Y. Y.; Ye, W. H.; Wang, L. F.; Wu, J. F.; Fan, Z. F.

2018-01-01

In this article, multiple eigen-systems including linear growth rates and eigen-functions have been discovered for the Rayleigh-Taylor instability (RTI) by numerically solving the Sturm-Liouville eigen-value problem in the case of two-dimensional plane geometry. The system called the first mode has the maximal linear growth rate and is just extensively studied in literature. Higher modes have smaller eigen-values, but possess multi-peak eigen-functions which bring on multiple pairs of vortices in the vorticity field. A general fitting expression for the first four eigen-modes is presented. Direct numerical simulations show that high modes lead to appearances of multi-layered spike-bubble pairs, and lots of secondary spikes and bubbles are also generated due to the interactions between internal spikes and bubbles. The present work has potential applications in many research and engineering areas, e.g., in reducing the RTI growth during capsule implosions in inertial confinement fusion.

SimBOX: a scalable architecture for aggregate distributed command and control of spaceport and service constellation

NASA Astrophysics Data System (ADS)

Prasad, Guru; Jayaram, Sanjay; Ward, Jami; Gupta, Pankaj

2004-08-01

In this paper, Aximetric proposes a decentralized Command and Control (C2) architecture for a distributed control of a cluster of on-board health monitoring and software enabled control systems called SimBOX that will use some of the real-time infrastructure (RTI) functionality from the current military real-time simulation architecture. The uniqueness of the approach is to provide a "plug and play environment" for various system components that run at various data rates (Hz) and the ability to replicate or transfer C2 operations to various subsystems in a scalable manner. This is possible by providing a communication bus called "Distributed Shared Data Bus" and a distributed computing environment used to scale the control needs by providing a self-contained computing, data logging and control function module that can be rapidly reconfigured to perform different functions. This kind of software-enabled control is very much needed to meet the needs of future aerospace command and control functions.

SimBox: a simulation-based scalable architecture for distributed command and control of spaceport and service constellations

NASA Astrophysics Data System (ADS)

Prasad, Guru; Jayaram, Sanjay; Ward, Jami; Gupta, Pankaj

2004-09-01

In this paper, Aximetric proposes a decentralized Command and Control (C2) architecture for a distributed control of a cluster of on-board health monitoring and software enabled control systems called SimBOX that will use some of the real-time infrastructure (RTI) functionality from the current military real-time simulation architecture. The uniqueness of the approach is to provide a "plug and play environment" for various system components that run at various data rates (Hz) and the ability to replicate or transfer C2 operations to various subsystems in a scalable manner. This is possible by providing a communication bus called "Distributed Shared Data Bus" and a distributed computing environment used to scale the control needs by providing a self-contained computing, data logging and control function module that can be rapidly reconfigured to perform different functions. This kind of software-enabled control is very much needed to meet the needs of future aerospace command and control functions.

Inequities of Intervention among Culturally and Linguistically Diverse Students

ERIC Educational Resources Information Center

Cramer, Liz

2015-01-01

Although Response to Intervention (RTI) has been generally studied in relation to student outcomes, the system itself requires further study, particularly for culturally and linguistically diverse (CLD) students. CLD students have consistently suffered inequities in the educational system, including over representation in high incidence disability…

Educator Perceptions of Response to Intervention

ERIC Educational Resources Information Center

DeLoach, Darcia

2017-01-01

Response to Intervention (RTI) is a research-based process in which students are provided timely intensive interventions. No longer adopting "wait to fail" models, this paradigm shift has challenged educators to employ systematic mathematics interventions which has been reported as challenging to implement within high schools. Therefore,…

Rural Practitioners' Involvement in Response to Intervention

ERIC Educational Resources Information Center

Cahill, Susan M.; McGuire, Beatriz; Krumdick, Nathaniel D.; Lee, Michelle M.

2015-01-01

Objective: This study describes perceived levels of involvement in school-based Response to Intervention (RtI) initiatives as reported by occupational therapy (OT) practitioners from different types of communities (i.e., rural, suburban, and urban). In addition, it identifies differences among practice patterns of rural OT practitioners, compared…

Teacher Resistance to the Response to Intervention Process: A Delphi Study

ERIC Educational Resources Information Center

Raines, Kerrie Lynn

2010-01-01

There has been a growing concern amongst educational stakeholders concerning the over identification of students with specific learning disabilities. The reauthorization of the Individuals with Disabilities Education improvement ACT in 2004 launched a response to intervention (RTI) process mandated early interventions for struggling students…

Elementary Preservice Teachers' Experiences with Response to Intervention

ERIC Educational Resources Information Center

Hurlbut, Amanda R.; Tunks, Jeanne

2016-01-01

Response to intervention (RTI) is a general education intervention system used by classroom teachers to assist struggling learners and provide individualized, academic support to help all students succeed academically. This process is also vital as a prereferral process as a prerequisite to special education referrals and eligibility…

Response to Intervention: A Research-Based Summary

ERIC Educational Resources Information Center

Hughes, Charles A.; Dexter, Douglas D.

2011-01-01

Response to Intervention (RTI) is an instructional framework through which schools can provide early intervention for students experiencing academic and behavioral difficulties. It is also promoted as an alternative to the IQ-discrepancy model for identifying students with learning disabilities. Most states have developed, or are developing,…

State Laws for RTI: An Updated Snapshot

ERIC Educational Resources Information Center

Zirkel, Perry A.; Thomas, Lisa B.

2010-01-01

Professionally, and ultimately legally, the definition of "specific learning disabilities" (SLD) has been "a long-standing source of controversy, conflict, and crisis." Yet students with SLD continue to be more numerous by far than any other group receiving special education services. The long-time controversy concerning the…

A Guide to the Kentucky System of Interventions

ERIC Educational Resources Information Center

Kentucky Department of Education, 2012

2012-01-01

The Kentucky System of Interventions (KSI) framework emphasizes optimizing instruction through targeted accelerated learning, development of teacher expertise and responsiveness to the needs of all learners. This approach to Response to Intervention (RtI) provides the structures needed for closing achievement gaps, ensuring readiness to learn and…

What Does the Law Say?

ERIC Educational Resources Information Center

Zirkel, Perry A.

2011-01-01

In this article, the author provides legal explanations to the following concerns: (1) case law on specific learning disability (SLD) eligibility; (2) recent developments on response to intervention (RTI); (3) Individuals with Disabilities Education Act (IDEA) rules; and (4) the Free Appropriate Public Education (FAPE) regulation. The author's…

Response to Intervention: Is the Sky Falling?

ERIC Educational Resources Information Center

Dougherty Stahl, Katherine A.

2016-01-01

Response to Intervention (RTI) is a multiple tiered system of instructional interventions that may also serve to identify children with Specific Learning Disabilities (particularly in reading and spelling). This article summarizes the findings of Evaluation of Response to Intervention Practices for Elementary School Reading (Balu, Zhu, Doolittle,…

A method for reducing environmental pollution by using essential oils in rodent pest management program.

PubMed

Jokić, Goran; Blažić, Tanja; Đurović-Pejčev, Rada; Đorđević, Tijana; Đedović, Suzana; Vukša, Marina

2017-08-01

Strong-smelling plant extracts, such as essential oils, have a variety of feeding effects on mammals. Considering current concerns over long-term health issues and environmental effects of chemicals, plant-based products with repellent or antifungal activities may represent good solutions for improvement of rodent pest control programs. The present study was therefore focused on examining the effects of bergamot, lavender, and thyme essential oils as additional bait components on daily intakes of cereal-based baits by wild house mice. Lavender essential oil, containing linalool and linalyl acetate as main components, and thyme essential oil with a prevailing thymol component had no effects on house mice diet. Bergamot essential oil, whose main components were linalool, limonene, and linalyl acetate, showed a repellent effect on house mouse diet.

Assessing the Impact of Early Learning Programs in Africa

ERIC Educational Resources Information Center

Gove, Amber; Brunette, Tracy; Bulat, Jennae; Carrol, Bidemi; Henny, Catherine; Macon, Wykia; Nderu, Evangeline; Sitabkhan, Yasmin

2017-01-01

We present results from early learning programs in six African countries: Ethiopia, Kenya, Liberia, Malawi, Tanzania, and Uganda. In partnership with ministries of education, RTI International has worked within government systems to support the design and deployment of locally contextualized materials, training, and assessment tools, with the goal…

Practical Handbook of School Psychology: Effective Practices for the 21st Century

ERIC Educational Resources Information Center

Peacock, Gretchen Gimpel, Ed.; Ervin, Ruth A., Ed.; Daly, Edward J., III, Ed.; Merrell, Kenneth W., Ed.

2009-01-01

This authoritative guide addresses all aspects of school psychology practice in a response-to-intervention (RTI) framework. Thirty-four focused chapters present effective methods for problem-solving-based assessment, instruction, and intervention. Specific guidelines are provided for promoting success in core academic domains--reading, writing,…

Functional Limitations of Vocational Rehabilitation (VR) Consumers Final Report

ERIC Educational Resources Information Center

Overman, Beth; Schmidt-Davis, Holly

2006-01-01

In response to a request from the Rehabilitation Services Administration (RSA), the Research Triangle Institute (RTI) conducted a study to examine the feasibility of developing functional status measures for planning and implementing services to consumers in the State-Federal Vocational Rehabilitation (VR) Services Program. To investigate this…

Middle School Response to Intervention and Student Achievement

ERIC Educational Resources Information Center

Smith, Kelly A. Obrion

2013-01-01

This ex post facto descriptive-comparative quantitative study compared the differences in reading achievement between groups of 6th- through 8th-grade students enrolled in a response to intervention (RtI) classroom against groups of students enrolled in a general education classroom. Students across English language learner and low socioeconomic…

Evidence-Based Early Reading Practices within a Response to Intervention System

ERIC Educational Resources Information Center

Bursuck, Bill; Blanks, Brooke

2010-01-01

Many students who experience reading failure are inappropriately placed in special education. A promising response to reducing reading failure and the overidentification of students for special education is Response to Intervention (RTI), a comprehensive early detection and prevention system that allows teachers to identify and support struggling…

Effect of a Targeted Early Literacy Intervention for English Learners

ERIC Educational Resources Information Center

Arellano, Elizabeth Michelle

2013-01-01

This study examined the effectiveness of a targeted early literacy intervention among Spanish-speaking kindergarten English Learners (ELs). Using a Response to Intervention (RtI) framework, participants were screened in English to ensure a need for additional literacy support. Selected students were then screened in Spanish, and students with…

Special Considerations with Response to Intervention and Instruction for Students with Diverse Backgrounds

ERIC Educational Resources Information Center

Hernandez Finch, Maria E.

2012-01-01

Response to Intervention (RtI) has been heralded as having significant promise for improving outcomes, reducing disproportional placement in special education, and making education more culturally responsive for culturally and linguistically diverse (CLD) youth. This article reviews the major recent empirical and qualitative research findings with…

Special Education Disproportionality: A Review of Response to Intervention and Culturally Relevant Pedagogy

ERIC Educational Resources Information Center

Cartledge, Gwendolyn; Kea, Cathy D.; Watson, Martreece; Oif, Alana

2016-01-01

Special education disproportionality for culturally and linguistically diverse (CLD) students persists as a controversial and intractable problem in our educational systems. Response to intervention (RtI) and culturally relevant pedagogy (CRP), both independently and collectively are considered to offer promise for mitigating conditions of…

Applications of aerospace technology

NASA Technical Reports Server (NTRS)

Rouse, D. J.; Brown, J. N., Jr.; Cleland, John; Lehrman, Stephen; Trachtman, Lawrence; Wallace, Robert; Winfield, Daniel; Court, Nancy; Maggin, Bernard; Barnett, Reed

1987-01-01

Highlights are presented for the Research Triangle Institute (RTI) Applications Team activities over the past quarter. Progress in fulfilling the requirements of the contract is summarized, along with the status of the eight add-on tasks. New problem statements are presented. Transfer activities for ongoing projects with the NASA Centers are included.

Response to Intervention and the Pyramid Model

ERIC Educational Resources Information Center

Fox, Lise; Carta, Judith; Strain, Phil; Dunlap, Glen; Hemmeter, Mary Louise

2009-01-01

Response to Intervention (RtI) offers a comprehensive model for the prevention of delays in learning and behavior. While this problem-solving framework was initially designed for application within Kindergarten to 12th grade programs, there is substantial research that supports the value of the model for application within early childhood…

NATIONAL STORMWATER CALCULATOR: LOW IMPACT DEVELOPMENT STORMWATER CONTROL COST ESTIMATION PROGRAMMING & FUTURE ENHANCEMENTS

EPA Science Inventory

National Stormwater Calculator: Low Impact Development Stormwater Control Cost Estimation Programming & Future EnhancementsJason Berner1; Michael Tryby1; Scott Struck2, Dan Pankani2, Marion Deerhake3, Michelle Simon11. USEPA2. GeoSyntec, Inc.3. RTI, Inc.The National Stormwater Ca...

Passage Equivalency and Predictive Validity of Oral Reading Fluency Measures

ERIC Educational Resources Information Center

Checca, Christopher Jason

2012-01-01

The use of oral reading fluency (ORF) passages within a Response to Intervention (RTI) framework is examined. Significant limitations within the current ORF research are discussed. The passage equivalency and readability scores for DIBELS Next, AIMSweb, and a school district's curriculum's ORF passages are evaluated using Generalizability Theory…

Technical Adequacy of Response to Intervention Decisions

ERIC Educational Resources Information Center

VanDerHeyden, Amanda M.

2011-01-01

Perhaps the greatest value of response to intervention (RTI) as a decision framework is that it brings attention to variables (e.g., mastery of prerequisite skills, frequency of instructional corrective feedback, reinforcement schedules for correct responding) that if changed might make a meaningful difference for students (e.g., child rate of…

Assess. Instruct. Repeat.

ERIC Educational Resources Information Center

Demski, Jennifer

2009-01-01

Response to Intervention, or RTI, is a framework for using data to establish the nature and degree of the help a student needs, and then applying strategies targeting those areas. It is a carefully drawn, systematic form of data-driven decision-making that establishes multiple stages of interventions for varying degrees of problems. Though some…

Fostering Reading Excellence at Every Level of School through Reading Clinics

ERIC Educational Resources Information Center

Ortlieb, Evan; Grandstaff-Beckers, Gerlinde; Cheek, Earl H., Jr.

2012-01-01

With the increased emphasis on standardized testing from state and federal mandates, the need for reading remediation has intensified. Programs directed toward increasing student test scores have been put in place nationwide with mixed results. These initiatives include response to intervention (RTI), direct instruction, and individualized…

A Rendering System Independent High Level Architecture Implementation for Networked Virtual Environments

DTIC Science & Technology

2002-09-01

Management .........................15 5. Time Management ..............................16 6. Data Distribution Management .................16 D...50 b. Ownership Management .....................51 c. Data Distribution Management .............51 2. Additional Objects and Interactions...16 Figure 6. Data Distribution Management . (From: ref. 2) ...16 Figure 7. RTI and Federate Code Responsibilities. (From: ref. 2

U.S. EPA, Pesticide Product Label, COSSMAN PATIO PELLETS, 12/15/1969

EPA Pesticide Factsheets

2011-04-14

... F 'iE."I ,'" I, • r !c't',:ing 11" p.>rti,le ,.,j hait. The S,ln'!:' ~ijt parti,:e :!,1'0' ki.: ' .. t ' ' "et're it 1,'ses i's etfe,·tiveile~". S(dttl'!- li,,:1tlv '1, ~rd •. ·.I"l·; ~". ...

RTI and Other Approaches to SLD Identification under the IDEA: A Legal Update

ERIC Educational Resources Information Center

Zirkel, Perry A.

2017-01-01

This article provides a concise and objective synthesis of the federal legislation, regulations, and agency policy interpretations; state laws; and case law, including hearing officer and complaint investigation decisions, concerning specific learning disability (SLD) identification since the 2006 IDEA regulations. The results reveal wide latitude…

PCB Content of Sediments Collected at Manistique Harbor, Michigan

DTIC Science & Technology

2014-06-01

2013 10:19 PM Page 23 of 35 Date Reported: 1/24/2013 Original WO#: 1211282RTI Laboratories - DATES REPORT Leachate Date USACE- Detroit District...REPORT Leachate Date USACE- Detroit District Manistique Harbor 0004 Client: Project: Sample ID Test NameMatrixCollection DateClient Sample ID Analysis

The "RAP" on Reading Comprehension

ERIC Educational Resources Information Center

Hagaman, Jessica L.; Luschen, Kati; Reid, Robert

2010-01-01

Reading problems are one of the most frequent reasons students are referred for special education services and the disparity between students with reading difficulties and those who read successfully appears to be increasing. As a result, there is now an emphasis on early intervention programs such as RTI. In many cases, early intervention in…

Responsiveness to Intervention in Reading: Architecture and Practices

ERIC Educational Resources Information Center

Jenkins, Joseph R.; Schiller, Ellen; Blackorby, Jose; Thayer, Sara Kalb; Tilly, W. David

2013-01-01

This article describes how a purposeful sample of 62 elementary schools from 17 states implemented a Response to Intervention (RtI) framework for reading. School informants answered surveys and were interviewed about differentiated instruction in Tier 1, screening/benchmarking, where Tier 2 interventions were located, typical group size and the…

Response to Intervention: Accountability in Action

ERIC Educational Resources Information Center

Hempenstall, Kerry

2012-01-01

Response to Intervention (RTI) is a popular if controversial initiative developed largely in the USA, but which is, as yet, little known in general education in Australia. However, this may change given the increased attention to accountability in recent times. The national NAPLAN and international PISA assessments are leading to pressure being…

INDOOR AIR EMISSIONS FROM OFFICE EQUIPMENT: TEST METHOD DEVELOPMENT AND POLLUTION PREVENTION OPPORTUNITIES

EPA Science Inventory

The report describes the development and evaluation of a large chamber test method for measuring emissions from dry-process photocopiers. The test method was developed in two phases. Phase 1 was a single-laboratory evaluation at Research Triangle Institute (RTI) using four, mid-r...

Seven Ways to Kill RTI

ERIC Educational Resources Information Center

Noll, Brandi

2013-01-01

The Response to Intervention initiative is in danger of failing and being thrown on the ash heaps of countless education reform initiatives, but not because it is poorly structured, rather on account of poor implementation. Among the implementation mistakes are seven that can be watched for and avoided. (Contains 3 tables.)

RtI in Math Class

ERIC Educational Resources Information Center

Gresham, Gina; Little, Mary

2012-01-01

One of the most difficult tasks that classroom teachers face is finding ways to reach all their students and match each student's level of mathematical readiness and performance to the skills they are required to teach. In classrooms and schools, current federal and state requirements have increased the emphasis on accountability for improved…

The Role of RtI in a Kindergarten Enrichment Program

ERIC Educational Resources Information Center

Hamm, Ellen M.; Harper, Kelly A.

2014-01-01

Researchers used a kindergarten screening to identify kindergarten students at risk for difficulties in reading (phonological awareness) and writing (fine motor and perceptual skills) prior to beginning the school year. Of the 102 incoming kindergarten students, 54 showed signs of reading or writing difficulties. These 54 children participated in…

Response to Intervention: "Lore v. Law"

ERIC Educational Resources Information Center

Zirkel, Perry A.

2018-01-01

The legal dimension of response to intervention (RTI) has been the subject of considerable professional confusion. This brief article addresses the issue in three parts. The first part provides an update of a previous iteration that compared 12 common conceptions, referred to here as the "lore," with an objective synthesis of the…

Response to Intervention Implementation Guide: The South Dakota Model

ERIC Educational Resources Information Center

South Dakota Department of Education, 2012

2012-01-01

The National Association of State Directors of Special Education (NASDSE, 2005) defines response to intervention (RTI) as the practice of providing high-quality instruction and intervention based on a student's needs, changing instruction and/or goals through frequent monitoring of progress, and applying the student response data to important…

Using High-Probability Instructional Sequences and Explicit Instruction to Teach Multiplication Facts

ERIC Educational Resources Information Center

Leach, Debra

2016-01-01

Students with learning disabilities often struggle with math fact fluency and require specialized interventions to recall basic facts. Deficits in math fact fluency can result in later difficulties when learning higher-level mathematical computation, concepts, and problem solving. The response-to-intervention (RTI) and…

Early Intervention for Reading Difficulties: The Interactive Strategies Approach

ERIC Educational Resources Information Center

Scanlon, Donna M.; Anderson, Kimberly L.; Sweeney, Joan M.

2010-01-01

This book presents a research-supported framework for early literacy instruction that aligns with multi-tiered response-to-intervention (RTI) models. The book focuses on giving teachers a better understanding of literacy development and how to effectively support children as they begin to read and write. The authors' interactive strategies…

Teacher Perceptions of the Effectiveness of the Response to Intervention (RTI) Process

ERIC Educational Resources Information Center

Anderson, Yarby

2017-01-01

With federal education mandates and new developments highlighting academic failures, additional stress has been placed on teachers and administrators to provide interventions to a student's specific deficit areas. Now, general education teachers are required to use research-based interventions to eliminate the decline in academic success. The…

The Teaching Revolution: RTI, Technology, and Differentiation Transform Teaching for the 21st Century

ERIC Educational Resources Information Center

Bender, William N.; Waller, Laura

2011-01-01

"The Teaching Revolution" challenges educators to imagine schools the way they should be, with a "big picture" vision that includes student-driven curricula, interconnectivity, and targeted responsiveness to students' individual needs. The authors provide a futuristic and provocative discussion on combining three major instructional…

Profile Building, Research Sharing and Data Proliferation using Social Media Tools for Scientists (RTI presentation)

EPA Science Inventory

Many of us nowadays invest significant amounts of time in sharing our activities and opinions with friends and family via social networking tools such as Facebook, Twitter or other related websites. However, despite the availability of many platforms for scientists to connect and...

What Is Intensive Instruction and Why Is It Important?

ERIC Educational Resources Information Center

Fuchs, Douglas; Fuchs, Lynn S.; Vaughn, Sharon

2014-01-01

In this article, the authors present two models of intensive instruction for students with and without disabilities who are having difficulties with Response to Intervention (RTI) currently in practice (Tier 1: general instruction that all students receive in mainstream classrooms, and Tier 2: programs often involving small group instruction). The…

Larvicidal effect of Eucalyptus grandis essential oil and turpentine and their major components on Aedes aegypti larvae.

PubMed

Lucia, Alejandro; Gonzalez Audino, Paola; Seccacini, Emilia; Licastro, Susana; Zerba, Eduardo; Masuh, Hector

2007-09-01

In the search for new alternatives for the control of Aedes aegypti the larvicidal activity of Eucalyptus grandis essential oil and pine resin essential oil (turpentine) and their major components (alpha- and beta-pinene and 1,8-cineole) was determined. Gas chromatography-mass spectroscopy analysis of E. grandis essential oil revealed that its major components are alpha-pinene and 1,8-cineole. Similar analysis of turpentine obtained by distillation of the resin pitch of conifers showed that alpha- and beta-pinene are the only major components. Third and early 4th instars of the CIPEIN-susceptible strain of Ae. aegypti were exposed to acetonic solutions of E. grandis essential oil, turpentine, and their major components for 24 h. Turpentine, with an LC50 of 14.7 ppm, was more active than the essential oil of E. grandis (LC50: 32.4 ppm). Larvicidal activity of the essential oil components showed that alpha- and beta-pinene present low LC50 values (15.4 and 12.1 ppm, respectively), whereas pure 1,8-cineole showed an LC50 of 57.2 ppm. These results suggest that alpha-pinene in E. grandis and alpha- and beta-pinene in turpentine serve as the principal larvicidal components of both oils. Results obtained on larvicidal effects of essential oil of Eucalyptus grandis and turpentine could be considered a contribution to the search for new biodegradable larvicides of natural origin.

Differentiation of essential oils in Atractylodes lancea and Atractylodes koreana by gas chromatography with mass spectrometry.

PubMed

Liu, Qiutao; Zhang, Shanshan; Yang, Xihui; Wang, Ruilin; Guo, Weiying; Kong, Weijun; Yang, Meihua

2016-12-01

Atractylodes rhizome is a valuable traditional Chinese medicinal herb that comprises complex several species whose essential oils are the primary pharmacologically active component. Essential oils of Atractylodes lancea and Atractylodes koreana were extracted by hydrodistillation, and the yield was determined. The average yield of essential oil obtained from A. lancea (2.91%) was higher than that from A. koreana (2.42%). The volatile components of the essential oils were then identified by a gas chromatography with mass spectrometry method that demonstrated good precision. The method showed clear differences in the numbers and contents of volatile components between the two species. 41 and 45 volatile components were identified in A. lancea and A. koreana, respectively. Atractylon (48.68%) was the primary volatile component in A. lancea, while eudesma-4(14)-en-11-ol (11.81%) was major in A. koreana. However, the most significant difference between A. lancea and A. koreana was the major component of atractylon and atractydin. Principal component analysis was utilized to reveal the correlation between volatile components and species, and the analysis was used to successfully discriminate between A. lancea and A. koreana samples. These results suggest that different species of Atractylodes rhizome may yield essential oils that differ significantly in content and composition. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

[Comparison of Chemical Components of Essential Oil from Ocimum basilicum var. pilosum Extracted by Supercritical CO2 Fluid and Steam Distillation].

PubMed

Wang, Zhao-yu; Zheng, Jia-huan; Shi, Sheng-ying; Luo, Zhi-xiong; Ni, Shun-yu; Lin, Jing-ming

2015-11-01

To compare the chemical components of essential oil prepared by steam distillation extraction (SD) and supercritical CO2 fluid extraction (SFE-CO2) from Ocimum basilicum var. pilosum whole plant. The essential oil of Ocimum basilicum var. pilosum were extracted by SD and SFE-CO2. The chemical components of essential oil were separated and analyzed by gas chromatography-mass spectrometry( GC-MS). Their relative contents were determined by normalization of peak area. 40 and 42 compounds were detected in the essential oil prepared by SD and SFE-CO2 respectively. 25 compounds were common. Thereare significant differences of the chemical components between the Ocimum basilicum var. pilosum essential oil prepared by SD and thatby SFE-CO2. Different methods showed different extraction efficiency with a special compound. It might be a good idea to unite several methods in the modern traditional Chinese medicine industry.

Enhanced monitoring of the temporal and spatial relationships between water demand and water availability

NASA Astrophysics Data System (ADS)

Schneider, C. A.; Aggett, G. R.; Hattendorf, M. J.

2007-12-01

Better information on evapotranspiration (ET) is essential to better understanding of consumptive use of water by crops. RTi is using NASA Earth-sun System research results and METRIC (Mapping ET at high Resolution with Internalized Calibration) to increase the repeatability and accuracy of consumptive use estimates. METRIC, an image-processing model for calculating ET as a residual of the surface energy balance, utilizes the thermal band on various satellite remote sensors. Calculating actual ET from satellites can avoid many of the assumptions driving other methods of calculating ET over a large area. Because it is physically based and does not rely on explicit knowledge of crop type in the field, a large potential source of error should be eliminated. This paper assesses sources of error in current operational estimates of ET for an area of the South Platte irrigated lands of Colorado, and benchmarks potential improvements in the accuracy of ET estimates gained using METRIC, as well as the processing efficiency of consumptive use demand for large irrigated lands. Examples highlighting how better water planning decisions and water management can be achieved via enhanced monitoring of the temporal and spatial relationships between water demand and water availability are provided.

Application of PLE for the determination of essential oil components from Thymus vulgaris L.

PubMed

Dawidowicz, Andrzej L; Rado, Ewelina; Wianowska, Dorota; Mardarowicz, Marek; Gawdzik, Jan

2008-08-15

Essential plants, due to their long presence in human history, their status in culinary arts, their use in medicine and perfume manufacture, belong to frequently examined stock materials in scientific and industrial laboratories. Because of a large number of freshly cut, dried or frozen plant samples requiring the determination of essential oil amount and composition, a fast, safe, simple, efficient and highly automatic sample preparation method is needed. Five sample preparation methods (steam distillation, extraction in the Soxhlet apparatus, supercritical fluid extraction, solid phase microextraction and pressurized liquid extraction) used for the isolation of aroma-active components from Thymus vulgaris L. are compared in the paper. The methods are mainly discussed with regard to the recovery of components which typically exist in essential oil isolated by steam distillation. According to the obtained data, PLE is the most efficient sample preparation method in determining the essential oil from the thyme herb. Although co-extraction of non-volatile ingredients is the main drawback of this method, it is characterized by the highest yield of essential oil components and the shortest extraction time required. Moreover, the relative peak amounts of essential components revealed by PLE are comparable with those obtained by steam distillation, which is recognized as standard sample preparation method for the analysis of essential oils in aromatic plants.

Composition and antimicrobial activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. essential oils and their major monoterpene alcohols alone and in combination.

PubMed

Bassolé, Imaël Henri Nestor; Lamien-Meda, Aline; Bayala, Balé; Tirogo, Souleymane; Franz, Chlodwig; Novak, Johannes; Nebié, Roger Charles; Dicko, Mamoudou Hama

2010-11-03

Essential oils from leaves of Lippia multiflora, Mentha x piperita and Ocimum basilicum from Burkina Faso were analysed by GC-FID and GC-MS. Major components were p-cymene, thymol, b-caryophyllene, carvacrol and carvone for L. multiflora, menthol and iso-menthone for M. x piperita and, linalool and eugenol for O. basilicum. The essential oils and their major monoterpene alcohols were tested against nine bacterial strains using the disc diffusion and broth microdilution methods. The essential oils with high phenolic contents were the most effective antimicrobials. The checkerboard method was used to quantify the efficacy of paired combinations of essential oils and their major components. The best synergetic effects among essential oils and major components were obtained with combinations involving O. basilicum essential oil and eugenol, respectively. As phenolic components are characterized by a strong spicy aroma, this study suggests that the selection of certain combinations of EOs could help to reduce the amount of essential oils and consequently reduce any adverse sensory impact in food.