TL-OSL correlation studies of LiMgPO4:Tb,B dosimetric phosphor

NASA Astrophysics Data System (ADS)

Singh, A. K.; Menon, S. N.; Dhabekar, Bhushan; Kadam, Sonal; Chougaonkar, M. P.; Mayya, Y. S.

2012-03-01

The recently synthesized LiMgPO4:Tb,B (LMP) is a highly sensitive Optically Stimulated Luminescence (OSL) phosphor for dosimetric applications. Studies were carried out to assess the correlation between thermoluminescence (TL) and OSL of this phosphor. Measurements like Residual TL (R-TL), Continuous Wave OSL (CW-OSL) and Linearly Modulated OSL (LM-OSL) of LMP were carried out and various curves thus obtained were de-convolved using Computerized Curve Deconvolution (CCD) program. The deconvolution of CW-OSL and LM-OSL curves showed five different first order components in LMP. It was observed that OSL signal of LMP has its origin from five traps having different photo-ionization cross-sections. Same traps were found to be responsible for both TL and OSL in this phosphor. Bleaching decay rates were calculated for each R-TL glow peaks and compared with the decay rates of individual OSL components. The value of decay rates of R-TL and OSL matches well. Experimental verification of presence of individual OSL components using tbleach-tmax method was carried out.

Evaluation of Intersection Traffic Control Measures through Simulation

NASA Astrophysics Data System (ADS)

Asaithambi, Gowri; Sivanandan, R.

2015-12-01

Modeling traffic flow is stochastic in nature due to randomness in variables such as vehicle arrivals and speeds. Due to this and due to complex vehicular interactions and their manoeuvres, it is extremely difficult to model the traffic flow through analytical methods. To study this type of complex traffic system and vehicle interactions, simulation is considered as an effective tool. Application of homogeneous traffic models to heterogeneous traffic may not be able to capture the complex manoeuvres and interactions in such flows. Hence, a microscopic simulation model for heterogeneous traffic is developed using object oriented concepts. This simulation model acts as a tool for evaluating various control measures at signalized intersections. The present study focuses on the evaluation of Right Turn Lane (RTL) and Channelised Left Turn Lane (CLTL). A sensitivity analysis was performed to evaluate RTL and CLTL by varying the approach volumes, turn proportions and turn lane lengths. RTL is found to be advantageous only up to certain approach volumes and right-turn proportions, beyond which it is counter-productive. CLTL is found to be advantageous for lower approach volumes for all turn proportions, signifying the benefits of CLTL. It is counter-productive for higher approach volume and lower turn proportions. This study pinpoints the break-even points for various scenarios. The developed simulation model can be used as an appropriate intersection lane control tool for enhancing the efficiency of flow at intersections. This model can also be employed for scenario analysis and can be valuable to field traffic engineers in implementing vehicle-type based and lane-based traffic control measures.

Partial MHC/Neuroantigen Peptide Constructs: A Potential Neuroimmune-Based Treatment for Methamphetamine Addiction

PubMed Central

Loftis, Jennifer M.; Wilhelm, Clare J.; Vandenbark, Arthur A.; Huckans, Marilyn

2013-01-01

Relapse rates following current methamphetamine abuse treatments are very high (∼40–60%), and the neuropsychiatric impairments (e.g., cognitive deficits, mood disorders) that arise and persist during remission from methamphetamine addiction likely contribute to these high relapse rates. Pharmacotherapeutic development of medications to treat addiction has focused on neurotransmitter systems with only limited success, and there are no Food and Drug Administration approved pharmacotherapies for methamphetamine addiction. A growing literature shows that methamphetamine alters peripheral and central immune functions and that immune factors such as cytokines, chemokines, and adhesion molecules play a role in the development and persistence of methamphetamine induced neuronal injury and neuropsychiatric impairments. The objective of this study was to evaluate the efficacy of a new immunotherapy, partial MHC/neuroantigen peptide construct (RTL551; pI-Ab/mMOG-35-55), in treating learning and memory impairments induced by repeated methamphetamine exposure. C57BL/6J mice were exposed to two different methamphetamine treatment regimens (using repeated doses of 4 mg/kg or 10 mg/kg, s.c.). Cognitive performance was assessed using the Morris water maze and CNS cytokine levels were measured by multiplex assay. Immunotherapy with RTL551 improved the memory impairments induced by repeated methamphetamine exposure in both mouse models of chronic methamphetamine addiction. Treatment with RTL551 also attenuated the methamphetamine induced increases in hypothalamic interleukin-2 (IL-2) levels. Collectively, these initial results indicate that neuroimmune targeted therapies, and specifically RTL551, may have potential as treatments for methamphetamine-induced neuropsychiatric impairments. PMID:23460798

Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes.

PubMed

Kagami, Masayo; Sekita, Yoichi; Nishimura, Gen; Irie, Masahito; Kato, Fumiko; Okada, Michiyo; Yamamori, Shunji; Kishimoto, Hiroshi; Nakayama, Masahiro; Tanaka, Yukichi; Matsuoka, Kentarou; Takahashi, Tsutomu; Noguchi, Mika; Tanaka, Yoko; Masumoto, Kouji; Utsunomiya, Takeshi; Kouzan, Hiroko; Komatsu, Yumiko; Ohashi, Hirofumi; Kurosawa, Kenji; Kosaki, Kenjirou; Ferguson-Smith, Anne C; Ishino, Fumitoshi; Ogata, Tsutomu

2008-02-01

Human chromosome 14q32.2 carries a cluster of imprinted genes including paternally expressed genes (PEGs) such as DLK1 and RTL1 and maternally expressed genes (MEGs) such as MEG3 (also known as GTL2), RTL1as (RTL1 antisense) and MEG8 (refs. 1,2), together with the intergenic differentially methylated region (IG-DMR) and the MEG3-DMR. Consistent with this, paternal and maternal uniparental disomy for chromosome 14 (upd(14)pat and upd(14)mat) cause distinct phenotypes. We studied eight individuals (cases 1-8) with a upd(14)pat-like phenotype and three individuals (cases 9-11) with a upd(14)mat-like phenotype in the absence of upd(14) and identified various deletions and epimutations affecting the imprinted region. The results, together with recent mouse data, imply that the IG-DMR has an important cis-acting regulatory function on the maternally inherited chromosome and that excessive RTL1 expression and decreased DLK1 and RTL1 expression are relevant to upd(14)pat-like and upd(14)mat-like phenotypes, respectively.

Real-time logic modelling on SpaceWire

NASA Astrophysics Data System (ADS)

Zhou, Qiang; Ma, Yunpeng; Fei, Haidong; Wang, Xingyou

2017-04-01

A SpaceWire is a standard for on-board satellite networks as the basis for future data-handling architectures. However, it cannot meet the deterministic requirement for safety/time critical application in spacecraft, where the delay of real-time (RT) message streams must be guaranteed. Therefore, SpaceWire-D is developed that provides deterministic delivery over a SpaceWire network. Formal analysis and verification of real-time systems is critical to their development and safe implementation, and is a prerequisite for obtaining their safety certification. Failure to meet specified timing constraints such as deadlines in hard real-time systems may lead to catastrophic results. In this paper, a formal verification method, Real-Time Logic (RTL), has been proposed to specify and verify timing properties of SpaceWire-D network. Based on the principal of SpaceWire-D protocol, we firstly analyze the timing properties of fundamental transactions, such as RMAP WRITE, and RMAP READ. After that, the RMAP WRITE transaction structure is modeled in Real-Time Logic (RTL) and Presburger Arithmetic representations. And then, the associated constraint graph and safety analysis is provided. Finally, it is suggested that RTL method can be useful for the protocol evaluation and provision of recommendation for further protocol evolutions.

The RTL-46: A simulated commercial air transportation study

NASA Technical Reports Server (NTRS)

Dunbar, Christian; Prette, John; Andersen, Gerald; Sprunck, Martin; Vogel, Christine; Rivera, Francisco

1993-01-01

The RTL-46 provides an aircraft which utilizes advanced technology within the fictional Aeroworld market to better service the air travel customers and airlines of Aeroworld. The RTL-46 is designed to serve the portion of the travel market which flies less than 10,000 feet per flight. The design cruise velocity for the aircraft is 35 ft/sec, which rapidly expedites travel through Aeroworld. The major focus of the endeavor was to design an aircraft which would serve the Aeroworld market better than the existing aircraft, the HB-40. This could have been done through targeting another portion of the Aeroworld market or through serving the current HB-40 market more effectively. Due to the fact that approximately 70 percent of the potential Aeroworld passengers desired flights of 10,000 ft or less, this range became the target market for the RTL-46.

Volcanic rocks and pyroclastica as time markers in sedimentary sequences - but how to date them? Examples from the Quaternary Eifel volcanism, German

NASA Astrophysics Data System (ADS)

Zoeller, Ludwig; Richter, Daniel; Klinger, Philip; van den Bogaard, Paul

2014-05-01

Volcanic rocks, in particular tephra, can serve as most valuable time markers in sedimentary sequences such as loess-paleosol sequences, lake sediments, fluvial sediments, etc. Young (Quaternary) volcanic products are often difficult to date with K/Ar or Ar/Ar methods, due to the long half-life of 40K and/or the lack of K-rich minerals in mafic volcanic products. 14C dating is problematic in volcanic environments and limited to < ca 50 ka. Direct dating of volcanic minerals by TL is strongly hampered by so-called "anomalous fading" of volcanic feldspars or pyroxenes. We tested the orange-red (620 nm) R-TL emission of quartz extracted from crustal xenoliths of some Quaternary Eifel volcanoes which were heated during the eruption. The R-TL emission of quartz appears to be suitable because of its high saturation dose which should allow for dating >1 Ma, and because of the lack of anomalous fading as reported in literature. Comparing our first apparent TL ages with new laser Ar/Ar ages from small autogenic phlogopit crystals we found, however, unexpected age underestimations for some samples. Further test relate this observation to the so-called anomalous fading of the quartz separates. Apparently, the temperature experienced by the xenolithic quartz grains during eruption is relevant for their TL stability characteristics. By improving and adjusting R-TL measurement protocols we were so far able to reproduce some 14C and Ar/Ar ages in the range of ca 40 ka to ca 600 ka. Our continuing work will focus on establishing R-TL dating of heated xenolithic quartz as a reliable method for Upper and Middle Pleistocene volcanic events.

Radiofrequency Thermal Lesioning and Extracorporeal Shockwave Therapy: A Comparison of Two Methods in the Treatment of Plantar Fasciitis.

PubMed

Ozan, Fırat; Koyuncu, Şemmi; Gürbüz, Kaan; Öncel, Eyyüp Sabri; Altay, Taşkın

2017-06-01

We compared the results of radiofrequency thermal lesioning (RTL) and extracorporeal shockwave therapy (ESWT) in patients with chronic plantar fasciitis. This prospective study included 56 patients diagnosed with plantar fasciitis who had complaints for ≥6 months: 40 (group 1) underwent ESWT and 16 (group 2) underwent RTL. The presence of calcaneal spurs was investigated with imaging studies. All patients were followed up clinically at baseline and 1, 3, and 6 months after treatment. Clinical evaluations were performed by the visual analog scale (VAS) and the modified Roles-Maudsley (RM) scoring system. There was no significant difference in the age, sex, body mass index, and side of involvement between the groups (all P > .05). Radiographic evaluation showed calcaneal spurs in 22 patients (55%) in group 1 and 7 patients (43%) in group 2. There was no significant difference in the baseline and posttreatment values between the groups; however, group 2 had significantly different RM values at 1 month than group 1 ( P < .05). In both groups, the VAS scores significantly decreased at 1, 3, and 6 months after treatment ( P < .05). The RM scores at 1, 3, and 6 months after treatment significantly decreased in both groups, except for the RM values at 1 month after treatment in group 1 ( P < .05). Our study results suggest that RTL and ESWT are safe and effective treatments in patients with chronic plantar fasciitis. Level II: Therapeutic study.

A novel pooled-sample multiplex luminex assay for high-throughput measurement of relative telomere length.

PubMed

Jasmine, Farzana; Shinkle, Justin; Sabarinathan, Mekala; Ahsan, Habibul; Pierce, Brandon L; Kibriya, Muhammad G

2018-03-12

Relative telomere length (RTL) is a potential biomarker of aging and risk for chronic disease. Previously, we developed a probe-based RTL assay on Luminex platform, where probes for Telomere (T) and reference gene (R) for a given DNA sample were tested in a single well. Here, we describe a method of pooling multiple samples in one well to increase the throughput and cost-effectiveness. We used four different microbeads for the same T-probe and four different microbeads for the same R-probe. Each pair of probe sets were hybridized to DNA in separate plates and then pooled in a single plate for all the subsequent steps. We used DNA samples from 60 independent individuals and repeated in multiple batches to test the precision. The precision was good to excellent with Intraclass correlation coefficient (ICC) of 0.908 (95% CI 0.856-0.942). More than 67% of the variation in the RTL could be explained by sample-to-sample variation; less than 0.1% variation was due to batch-to-batch variation and 0.3% variation was explained by bead-to-bead variation. We increased the throughput of RTL Luminex assay from 60 to 240 samples per run. The new assay was validated against the original Luminex assay without pooling (r = 0.79, P = 1.44 × 10 -15 ). In an independent set of samples (n = 550), the new assay showed a negative correlation of RTL with age (r = -0.41), a result providing external validation for the method. We describe a novel high throughput pooled-sample multiplex Luminex assay for RTL with good to excellent precision suitable for large-scale studies. © 2018 Wiley Periodicals, Inc.

Thermochronometry using red TL of quartz - a feasibility study from in-situ drill-hole samples

NASA Astrophysics Data System (ADS)

Schmidt, Christoph; Zöller, Ludwig

2015-04-01

Thermochronometry - the revelation of the temperature history of rock related to subsidence or uplift and erosion - relies on methods with closure temperatures >40-70 °C, such as (U-Th-Sm)/He or fission track analysis on apatite. These methods are applicable to young and tectonically active mountain ranges, but results of calculated mean denudation rates are too imprecise for older orogens. Several studies attested the quartz luminescence signal (325 °C TL peak, OSL fast component) isothermal decay at ambient temperatures as low as 56 °C (Prokein and Wagner, 1994; Herman et al., 2010; de Sarkar et al., 2013). The so far determined closure temperatures of the quartz luminescence thermochronometry system vary between ~35 °C for the OSL fast component (Herman et al., 2010) and ~70 °C for red thermoluminescence (RTL; Tsuchiya and Fujino, 2000) and are dependent on the cooling rate and the charge trap parameters. Although featuring a favourably low closure temperature - thus allowing to study the geologically most recent temperature history -, especially quartz OSL suffers from low dose saturation, limiting the application to highly erosive orogens. Saturation doses of RTL exceed those of OSL by a factor of 10 or more (Fattahi and Stokes, 2000), what opens up new perspectives in low-temperature thermochronometry. We here present experimental results on the general suitability of RTL for thermochronometry, obtained for samples from a drilling hole in the granitic basement of the Variscan Fichtelgebirge (Franconia, Germany). The samples allowed studying the RTL signal saturation level in-situ at different ambient temperatures up to ~55 °C (at 1831 m depth). Measurements confirmed depletion of the 325 °C RTL peak for ambient temperatures >25 °C, most probably for even lower temperatures. Irradiation experiments showed that the RTL signal is not in saturation for ambient temperatures >25 °C, even for this 'old' mountain range. We could further demonstrate that the luminescence sensitivity of samples strongly increases with rising ambient temperature, opposite to the findings of Ypma and Hochman (1991) for samples from sedimentary basins. References Fattahi, M., Stokes, S., 2000. Extending the time range of luminescence dating using red TL (RTL) from volcanic quartz. Radiation Measurements 32, 479-485. Herman, F., Rhodes, E.J., Braun, J., Heiniger, L., 2010. Uniform erosion rates and relief amplitude during glacial cycles in the Southern Alps of New Zealand, as revealed from OSL-thermochronology. Earth and Planetary Science Letters 297, 183-189. Prokein, J., Wagner, G.A., 1994. Analysis of thermoluminescent glow peaks in quartz derived from the KTB-drill hole. Radiation Measurements 23, 85-94. de Sarkar, S., Mathew, G., Pande, K., Chauhan, N., Singhvi, A.K., 2013. Rapid denudation of Higher Himalaya during late Pleistocence, evidence from OSL thermochronology. Geochronometria 40, 304-310. Tsuchiya, N., Fujino, K., 2000. Evaluation of cooling history of the Quaternary Takidani pluton using thermoluminescence technique. Proceedings World Geothermal Congress, Kyushu-Tohoku, Japan. Ypma, P.J., Hochman, M.B., 1991. Thermoluminescence geothermometry - a case study of the Otway basin. APEA Journal, 312-324.

Use of photogrammetry as a means to assess hybrids of rhesus (Macaca mulatta) and long-tailed (M. fascicularis) macaques.

PubMed

Jadejaroen, Janya; Hamada, Yuzuru; Kawamoto, Yoshi; Malaivijitnond, Suchinda

2015-01-01

Rhesus (Macaca mulatta) and long-tailed (M. fascicularis) macaques are the most commonly used non-human primate models for biomedical research, but it is difficult to identify these two species in the hybrid zone (15-20°N). In this work, we used morphological values obtained via photogrammetry to assess hybrids of rhesus and long-tailed macaques at Khao Khieow Open Zoo (KKZ; 13°21'N, 101°06'E), eastern Thailand. Long-tailed and rhesus macaques have species-specific tail lengths and contrasts of their yellowish pelages. The accuracy and precision of the relative tail length (%RTL) and the contrast of the yellow hue (Cb*) of the pelage, as obtained from photographs, were compared with the corresponding direct measurements (morphometrics). The photogrammetric and morphometric measurements of %RTL and Cb* were highly significantly correlated (r = 0.989 and 0.980, p < 0.001), and there were no significant differences between the two datasets (t test, p = 0.13 and 0.41; n = 42 and 17 for %RTL and Cb*, respectively). The reproducibilities of the %RTL and Cb* measurements (calculated in the photogrammetric case by taking photographs of the same macaques in two different environments) were significantly correlated between the datasets (r = 0.983 and 0.914, p < 0.001 and 0.005), and there were no significant differences between the datasets (t test, p = 0.539 and 0.344; n = 30 each for %RTL and Cb*, respectively). The %RTL and Cb* data were combined with data on the crown and cheek hair patterns and sex skin reddening of the macaques, and this combined data set was then analyzed by multiple correspondence analysis and agglomerative hierarchical cluster analysis, leading to the categorization of the rhesus macaques, long-tailed macaques, and hybrids at KKZ into five groups. Thus, photogrammetry can be utilized to identify macaque species or hybrids when species identification relies mainly on tail length and pelage color.

Maize and Arabidopsis ARGOS Proteins Interact with Ethylene Receptor Signaling Complex, Supporting a Regulatory Role for ARGOS in Ethylene Signal Transduction[OPEN

PubMed Central

Shi, Jinrui; Wang, Hongyu; Habben, Jeffrey E.

2016-01-01

The phytohormone ethylene regulates plant growth and development as well as plant response to environmental cues. ARGOS genes reduce plant sensitivity to ethylene when overexpressed in transgenic Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). A previous genetic study suggested that the endoplasmic reticulum and Golgi-localized maize ARGOS1 targets the ethylene signal transduction components at or upstream of CONSTITUTIVE TRIPLE RESPONSE1, but the mechanism of ARGOS modulating ethylene signaling is unknown. Here, we demonstrate in Arabidopsis that ZmARGOS1, as well as the Arabidopsis ARGOS homolog ORGAN SIZE RELATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene receptor interacting protein that regulates the activity of ETHYLENE RESPONSE1. The protein-protein interaction was also detected with the yeast split-ubiquitin two-hybrid system. Using the same yeast assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and ZmRTL2 also interact with maize and Arabidopsis ARGOS proteins. Like AtRTE1 in Arabidopsis, ZmRTL4 and ZmRTL2 reduce ethylene responses when overexpressed in maize, indicating a similar mechanism for ARGOS regulating ethylene signaling in maize. A polypeptide fragment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS family, can interact with AtRTE1 and maize RTL proteins in Arabidopsis. The conserved domain is necessary and sufficient to reduce ethylene sensitivity in Arabidopsis and maize. Overall, these results suggest a physical association between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, supporting a role for ARGOS in regulating ethylene perception and the early steps of signal transduction in Arabidopsis and maize. PMID:27268962

Maize and Arabidopsis ARGOS Proteins Interact with Ethylene Receptor Signaling Complex, Supporting a Regulatory Role for ARGOS in Ethylene Signal Transduction.

PubMed

Shi, Jinrui; Drummond, Bruce J; Wang, Hongyu; Archibald, Rayeann L; Habben, Jeffrey E

2016-08-01

The phytohormone ethylene regulates plant growth and development as well as plant response to environmental cues. ARGOS genes reduce plant sensitivity to ethylene when overexpressed in transgenic Arabidopsis (Arabidopsis thaliana) and maize (Zea mays). A previous genetic study suggested that the endoplasmic reticulum and Golgi-localized maize ARGOS1 targets the ethylene signal transduction components at or upstream of CONSTITUTIVE TRIPLE RESPONSE1, but the mechanism of ARGOS modulating ethylene signaling is unknown. Here, we demonstrate in Arabidopsis that ZmARGOS1, as well as the Arabidopsis ARGOS homolog ORGAN SIZE RELATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene receptor interacting protein that regulates the activity of ETHYLENE RESPONSE1. The protein-protein interaction was also detected with the yeast split-ubiquitin two-hybrid system. Using the same yeast assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and ZmRTL2 also interact with maize and Arabidopsis ARGOS proteins. Like AtRTE1 in Arabidopsis, ZmRTL4 and ZmRTL2 reduce ethylene responses when overexpressed in maize, indicating a similar mechanism for ARGOS regulating ethylene signaling in maize. A polypeptide fragment derived from ZmARGOS8, consisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members of the ARGOS family, can interact with AtRTE1 and maize RTL proteins in Arabidopsis. The conserved domain is necessary and sufficient to reduce ethylene sensitivity in Arabidopsis and maize. Overall, these results suggest a physical association between ARGOS and the ethylene receptor signaling complex via AtRTE1 and maize RTL proteins, supporting a role for ARGOS in regulating ethylene perception and the early steps of signal transduction in Arabidopsis and maize. © 2016 American Society of Plant Biologists. All Rights Reserved.

Is telomere length associated with mate choice in a songbird with a high rate of extra-pair paternity?

PubMed

Johnsen, Arild; Pauliny, Angela; Lifjeld, Jan T; Blomqvist, Donald

2017-01-01

Telomere length is related to aging in many eukaryotes and the rate of telomere attrition has been suggested to reflect individual genetic quality. Telomere length could thus have implications for mate choice. We investigated telomere length variation in bluethroat Luscinia svecica families with mixed paternity, including social parents, extra-pair fathers and nestlings, testing whether telomere length is associated with social and/or extra-pair mate choice through assortative mating or selection of mates with relatively long telomeres. In adults, relative telomere length (rTL) did not differ between the sexes, nor between two age categories. In chicks, however, rTL decreased with body mass at sampling (an index of nestling age). We found a positive correlation between the rTL of social mates, suggesting assortative mating with respect to telomere length or a correlative thereof. However, extra-pair males did not differ from social mates in rTL, and accordingly there was also no difference between within- and extra-pair young (i.e. half-siblings) when controlling for the effect of mass. We found no relationships between telomere length, age and fitness-related traits in adults, but an intriguing year-difference in telomere length in both sexes. In conclusion, we found no support for the idea that females choose extra-pair males based on their telomere length, but social mate choice seems to be influenced by rTL, possibly through its co-variation with aspects reflecting individual quality, like early arrival at the breeding grounds.

Effects of multiwalled carbon nanotubes and triclocarban on several eukaryotic cell lines: elucidating cytotoxicity, endocrine disruption, and reactive oxygen species generation

PubMed Central

2014-01-01

To date, only a few reports about studies on toxic effects of carbon nanotubes (CNT) are available, and their results are often controversial. Three different cell lines (rainbow trout liver cells (RTL-W1), human adrenocortical carcinoma cells (T47Dluc), and human adrenocarcinoma cells (H295R)) were exposed to multiwalled carbon nanotubes, the antimicrobial agent triclocarban (TCC) as well as the mixture of both substances in a concentration range of 3.13 to 50 mg CNT/L, 31.25 to 500 μg TCC/L, and 3.13 to 50 mg CNT/L + 1% TCC (percentage relative to carbon nanotubes concentration), respectively. Triclocarban is a high-production volume chemical that is widely used as an antimicrobial compound and is known for its toxicity, hydrophobicity, endocrine disruption, bioaccumulation potential, and environmental persistence. Carbon nanotubes are known to interact with hydrophobic organic compounds. Therefore, triclocarban was selected as a model substance to examine mixture toxicity in this study. The influence of multiwalled carbon nanotubes and triclocarban on various toxicological endpoints was specified: neither cytotoxicity nor endocrine disruption could be observed after exposure of the three cell lines to carbon nanotubes, but the nanomaterial caused intracellular generation of reactive oxygen species in all cell types. For TCC on the other hand, cell vitality of 80% could be observed at a concentration of 2.1 mg/L for treated RTL-W1 cells. A decrease of luciferase activity in the ER Calux assay at a triclocarban concentration of 125 μg/L and higher was observed. This effect was less pronounced when multiwalled carbon nanotubes were present in the medium. Taken together, these results demonstrate that multiwalled carbon nanotubes induce the production of reactive oxygen species in RTL-W1, T47Dluc, and H295R cells, reveal no cytotoxicity, and reduce the bioavailability and toxicity of the biocide triclocarban. PMID:25170332

Effects of multiwalled carbon nanotubes and triclocarban on several eukaryotic cell lines: elucidating cytotoxicity, endocrine disruption, and reactive oxygen species generation

NASA Astrophysics Data System (ADS)

Simon, Anne; Maletz, Sibylle X.; Hollert, Henner; Schäffer, Andreas; Maes, Hanna M.

2014-08-01

To date, only a few reports about studies on toxic effects of carbon nanotubes (CNT) are available, and their results are often controversial. Three different cell lines (rainbow trout liver cells (RTL-W1), human adrenocortical carcinoma cells (T47Dluc), and human adrenocarcinoma cells (H295R)) were exposed to multiwalled carbon nanotubes, the antimicrobial agent triclocarban (TCC) as well as the mixture of both substances in a concentration range of 3.13 to 50 mg CNT/L, 31.25 to 500 μg TCC/L, and 3.13 to 50 mg CNT/L + 1% TCC (percentage relative to carbon nanotubes concentration), respectively. Triclocarban is a high-production volume chemical that is widely used as an antimicrobial compound and is known for its toxicity, hydrophobicity, endocrine disruption, bioaccumulation potential, and environmental persistence. Carbon nanotubes are known to interact with hydrophobic organic compounds. Therefore, triclocarban was selected as a model substance to examine mixture toxicity in this study. The influence of multiwalled carbon nanotubes and triclocarban on various toxicological endpoints was specified: neither cytotoxicity nor endocrine disruption could be observed after exposure of the three cell lines to carbon nanotubes, but the nanomaterial caused intracellular generation of reactive oxygen species in all cell types. For TCC on the other hand, cell vitality of 80% could be observed at a concentration of 2.1 mg/L for treated RTL-W1 cells. A decrease of luciferase activity in the ER Calux assay at a triclocarban concentration of 125 μg/L and higher was observed. This effect was less pronounced when multiwalled carbon nanotubes were present in the medium. Taken together, these results demonstrate that multiwalled carbon nanotubes induce the production of reactive oxygen species in RTL-W1, T47Dluc, and H295R cells, reveal no cytotoxicity, and reduce the bioavailability and toxicity of the biocide triclocarban.

2012 Preschool Pilot Study of PBS KIDS Transmedia Mathematics Content: A Report to the CPB-PBS "Ready to Learn Initiative"

ERIC Educational Resources Information Center

Pasnik, Shelley; Llorente, Carlin

2012-01-01

The 2012 Preschool Pilot Study of PBS KIDS Transmedia Mathematics Content (Preschool Pilot) is an important part of the authors' multiyear "Ready To Learn" (RTL) summative evaluation initiative. Through this initiative funded by the Corporation for Public Broadcasting (CPB) and Public Broadcasting Service (PBS), it was the responsibility…

Predicted structure of MIF/CD74 and RTL1000/CD74 complexes.

PubMed

Meza-Romero, Roberto; Benedek, Gil; Leng, Lin; Bucala, Richard; Vandenbark, Arthur A

2016-04-01

Macrophage migration inhibitory factor (MIF) is a key cytokine in autoimmune and inflammatory diseases that attracts and then retains activated immune cells from the periphery to the tissues. MIF exists as a homotrimer and its effects are mediated through its primary receptor, CD74 (the class II invariant chain that exhibits a highly structured trimerization domain), present on class II expressing cells. Although a number of binding residues have been identified between MIF and CD74 trimers, their spatial orientation has not been established. Using a docking program in silico, we have modeled binding interactions between CD74 and MIF as well as CD74 and a competitive MIF inhibitor, RTL1000, a partial MHC class II construct that is currently in clinical trials for multiple sclerosis. These analyses revealed 3 binding sites on the MIF trimer that each were predicted to bind one CD74 trimer through interactions with two distinct 5 amino acid determinants. Surprisingly, predicted binding of one CD74 trimer to a single RTL1000 antagonist utilized the same two 5 residue determinants, providing strong suggestive evidence in support of the MIF binding regions on CD74. Taken together, our structural modeling predicts a new MIF(CD74)3 dodecamer that may provide the basis for increased MIF potency and the requirement for ~3-fold excess RTL1000 to achieve full antagonism.

Improving students’ mathematical critical thinking through rigorous teaching and learning model with informal argument

NASA Astrophysics Data System (ADS)

Hamid, H.

2018-01-01

The purpose of this study is to analyze an improvement of students’ mathematical critical thinking (CT) ability in Real Analysis course by using Rigorous Teaching and Learning (RTL) model with informal argument. In addition, this research also attempted to understand students’ CT on their initial mathematical ability (IMA). This study was conducted at a private university in academic year 2015/2016. The study employed the quasi-experimental method with pretest-posttest control group design. The participants of the study were 83 students in which 43 students were in the experimental group and 40 students were in the control group. The finding of the study showed that students in experimental group outperformed students in control group on mathematical CT ability based on their IMA (high, medium, low) in learning Real Analysis. In addition, based on medium IMA the improvement of mathematical CT ability of students who were exposed to RTL model with informal argument was greater than that of students who were exposed to CI (conventional instruction). There was also no effect of interaction between RTL model and CI model with both (high, medium, and low) IMA increased mathematical CT ability. Finally, based on (high, medium, and low) IMA there was a significant improvement in the achievement of all indicators of mathematical CT ability of students who were exposed to RTL model with informal argument than that of students who were exposed to CI.

Component resolved bleaching study in natural calcium fluoride using CW-OSL, LM-OSL and residual TL glow curves after bleaching.

PubMed

Angeli, Vasiliki; Polymeris, George S; Sfampa, Ioanna K; Tsirliganis, Nestor C; Kitis, George

2017-04-01

Natural calcium fluoride has been commonly used as thermoluminescence (TL) dosimeter due to its high luminescence intensity. The aim of this work includes attempting a correlation between specific TL glow curves after bleaching and components of linearly modulated optically stimulated luminescence (LM-OSL) as well as continuous wave OSL (CW-OSL). A component resolved analysis was applied to both integrated intensity of the RTL glow curves and all OSL decay curves, by using a Computerized Glow-Curve De-convolution (CGCD) procedure. All CW-OSL and LM-OSL components are correlated to the decay components of the integrated RTL signal, apart from two RTL components which cannot be directly correlated with either LM-OSL or CW-OSL component. The unique, stringent criterion for this correlation deals with the value of the decay constant λ of each bleaching component. There is only one, unique bleaching component present in all three luminescence entities which were the subject of the present study, indicating that each TL trap yields at least three different bleaching components; different TL traps can indicate bleaching components with similar values. According to the data of the present work each RTL bleaching component receives electrons from at least two peaks. The results of the present study strongly suggest that the traps that contribute to TL and OSL are the same. Copyright © 2017 Elsevier Ltd. All rights reserved.

Comparative Cytotoxicity Study of Silver Nanoparticles (AgNPs) in a Variety of Rainbow Trout Cell Lines (RTL-W1, RTH-149, RTG-2) and Primary Hepatocytes

PubMed Central

Connolly, Mona; Fernandez-Cruz, Maria-Luisa; Quesada-Garcia, Alba; Alte, Luis; Segner, Helmut; Navas, Jose M.

2015-01-01

Among all classes of nanomaterials, silver nanoparticles (AgNPs) have potentially an important ecotoxicological impact, especially in freshwater environments. Fish are particularly susceptible to the toxic effects of silver ions and, with knowledge gaps regarding the contribution of dissolution and unique particle effects to AgNP toxicity, they represent a group of vulnerable organisms. Using cell lines (RTL-W1, RTH-149, RTG-2) and primary hepatocytes of rainbow trout (Oncorhynchus mykiss) as in vitro test systems, we assessed the cytotoxicity of the representative AgNP, NM-300K, and AgNO3 as an Ag+ ion source. Lack of AgNP interference with the cytotoxicity assays (AlamarBlue, CFDA-AM, NRU assay) and their simultaneous application point to the compatibility and usefulness of such a battery of assays. The RTH-149 and RTL-W1 liver cell lines exhibited similar sensitivity as primary hepatocytes towards AgNP toxicity. Leibovitz’s L-15 culture medium composition (high amino acid content) had an important influence on the behaviour and toxicity of AgNPs towards the RTL-W1 cell line. The obtained results demonstrate that, with careful consideration, such an in vitro approach can provide valuable toxicological data to be used in an integrated testing strategy for NM-300K risk assessment. PMID:26006119

Postsacral vertebral morphology in relation to tail length among primates and other mammals.

PubMed

Russo, Gabrielle A

2015-02-01

Tail reduction/loss independently evolved in a number of mammalian lineages, including hominoid primates. One prerequisite to appropriately contextualizing its occurrence and understanding its significance is the ability to track evolutionary changes in tail length throughout the fossil record. However, to date, the bony correlates of tail length variation among living taxa have not been comprehensively examined. This study quantifies postsacral vertebral morphology among living primates and other mammals known to differ in relative tail length (RTL). Linear and angular measurements with known biomechanical significance were collected on the first, mid-, and transition proximal postsacral vertebrae, and their relationship with RTL was assessed using phylogenetic generalized least-squares regression methods. Compared to shorter-tailed primates, longer-tailed primates possess a greater number of postsacral vertebral features associated with increased proximal tail flexibility (e.g., craniocaudally longer vertebral bodies), increased intervertebral body joint range of motion (e.g., more circularly shaped cranial articular surfaces), and increased leverage of tail musculature (e.g., longer spinous processes). These observations are corroborated by the comparative mammalian sample, which shows that distantly related short-tailed (e.g., Phascolarctos, Lynx) and long-tailed (e.g., Dendrolagus, Acinonyx) nonprimate mammals morphologically converge with short-tailed (e.g., Macaca tonkeana) and long-tailed (e.g., Macaca fascicularis) primates, respectively. Multivariate models demonstrate that the variables examined account for 70% (all mammals) to 94% (only primates) of the variance in RTL. Results of this study may be used to infer the tail lengths of extinct primates and other mammals, thereby improving our understanding about the evolution of tail reduction/loss. © 2014 Wiley Periodicals, Inc.

No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia.

PubMed

Gadalla, Shahinaz M; Wang, Tao; Loftus, David; Friedman, Lyssa; Dagnall, Casey; Haagenson, Michael; Spellman, Stephen R; Buturovic, Ljubomir; Blauwkamp, Marsha; Shelton, Jason; Fleischhauer, Katharina; Hsu, Katharine C; Verneris, Michael R; Krstajic, Damjan; Hicks, Belynda; Jones, Kristine; Lee, Stephanie J; Savage, Sharon A

2018-04-01

Recent studies suggest improved survival in patients with severe aplastic anemia receiving hematopoietic cell transplant (HCT) from unrelated donors with longer telomeres. Here, we tested whether this effect is generalizable to patients with acute leukemia. From the Center for International Blood and Marrow Transplant Research (CIBMTR ® ) database, we identified 1097 patients who received 8/8 HLA-matched unrelated HCT for acute myeloid leukemia (AML) or acute lymphocytic leukemia (ALL) between 2004 and 2012 with myeloablative conditioning, and had pre-HCT blood sample from the donor in CIBMTR repository. The median age at HCT for recipients was 40 years (range ≤1-68), and 32 years for donors (range = 18-61). We used qPCR for relative telomere length (RTL) measurement, and Cox proportional hazard models for statistical analyses. In a discovery cohort of 300 patients, longer donor RTL (>25th percentile) was associated with reduced risks of relapse (HR = 0.62, p = 0.05) and acute graft-versus-host disease II-IV (HR = 0.68, p = 0.05), and possibly with a higher probability of neutrophil engraftment (HR = 1.3, p = 0.06). However, these results did not replicate in two validation cohorts of 297 and 488 recipients. There was one exception; a higher probability of neutrophil engraftment was observed in one validation cohort (HR = 1.24, p = 0.05). In a combined analysis of the three cohorts, no statistically significant associations (all p > 0.1) were found between donor RTL and any outcomes.

When to Randomize: Lessons from Independent Impact Evaluation of Reading to Learn (RtL) Programme to Improve Literacy and Numeracy in Kenya and Uganda

ERIC Educational Resources Information Center

Oketch, Moses; Ngware, Moses; Mutisya, Maurice; Kassahun, Admassu; Abuya, Benta; Musyoka, Peter

2014-01-01

In East Africa, there is great effort directed toward ensuring that there is learning and value for money invested in universal education policies initiated over the past decade. Kenya and Uganda are two countries that typify this effort. The effort includes the work of research organisations such as Uwezo, which assess learning levels; RTI, which…

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PubMed

Archampong, Timothy Na; Boyce, Ceejay L; Lartey, Margaret; Sagoe, Kwamena W; Obo-Akwa, Adjoa; Kenu, Ernest; Blackard, Jason T; Kwara, Awewura

2017-01-01

The presence of HBV resistance mutations upon initiation or during antiretroviral therapy (ART) in HIV-coinfected patients is an important determinant of treatment response. The main objective of the study was to determine the prevalence of HBV resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected Ghanaian patients with detectable HBV viraemia. HBV-HIV-coinfected patients who were ART-naive or had received at least 9 months of lamivudine (3TC)-containing ART were enrolled in a cross-sectional study. Demographic and clinical data were collected and HBV DNA quantified. Partial HBV sequences were amplified by PCR and sequenced bi-directionally to obtain a 2.1-2.2 kb fragment for phylogenetic analysis of HBV genotypes and evaluation of drug resistance mutations. Of the 100 HBV-HIV-coinfected study patients, 75 were successfully PCR-amplified, and 63 were successfully sequenced. Of these 63 patients, 27 (42.9%) were ART-experienced and 58 (92.1%) had HBV genotype E. No resistance mutations were observed in the 36 ART-naive patients, while 21 (77.8%) of 27 treatment-experienced patients had resistance mutations. All patients with resistance mutations had no tenofovir in their regimens, and 80% of them had HIV RNA <40 copies/ml. The 3TC resistance mutations rtL180M and rtM204V were observed in 10 (47.6%) of the 21 patients, while 5 patients (23.8%) had rtV173L, rtL180M and rtM204V mutations. A high proportion of HBV-HIV-coinfected patients with detectable viraemia on 3TC-containing ART had resistance mutations despite good ART adherence as determined by HIV RNA suppression. This study emphasizes the need for dual therapy as part of a fully suppressive ART in all HBV-HIV-coinfected patients in Ghana.

Clinical features associated with copy number variations of the 14q32 imprinted gene cluster.

PubMed

Rosenfeld, Jill A; Fox, Joyce E; Descartes, Maria; Brewer, Fallon; Stroud, Tracy; Gorski, Jerome L; Upton, Sheila J; Moeschler, John B; Monteleone, Berrin; Neill, Nicholas J; Lamb, Allen N; Ballif, Blake C; Shaffer, Lisa G; Ravnan, J Britt

2015-02-01

Uniparental disomy (UPD) for imprinted chromosomes can cause abnormal phenotypes due to absent or overexpression of imprinted genes. UPD(14)pat causes a unique constellation of features including thoracic skeletal anomalies, polyhydramnios, placentomegaly, and limited survival; its hypothesized cause is overexpression of paternally expressed RTL1, due to absent regulatory effects of maternally expressed RTL1as. UPD(14)mat causes a milder condition with hypotonia, growth failure, and precocious puberty; its hypothesized cause is absence of paternally expressed DLK1. To more clearly establish how gains and losses of imprinted genes can cause disease, we report six individuals with copy number variations of the imprinted 14q32 region identified through clinical microarray-based comparative genomic hybridization. Three individuals presented with UPD(14)mat-like phenotypes (Temple syndrome) and had apparently de novo deletions spanning the imprinted region, including DLK1. One of these deletions was shown to be on the paternal chromosome. Two individuals with UPD(14)pat-like phenotypes had 122-154kb deletions on their maternal chromosomes that included RTL1as but not the differentially methylated regions that regulate imprinted gene expression, providing further support for RTL1 overexpression as a cause for the UPD(14)pat phenotype. The sixth individual is tetrasomic for a 1.7Mb segment, including the imprinted region, and presents with intellectual disability and seizures but lacks significant phenotypic overlap with either UPD(14) syndrome. Therefore, the 14q32 imprinted region is dosage sensitive, with deletions of different critical regions causing UPD(14)mat- and UPD(14)pat-like phenotypes, while copy gains are likely insufficient to recapitulate these phenotypes.

Myostatin-deficiency in mice increases global gene expression at the Dlk1-Dio3 locus in the skeletal muscle

PubMed Central

Hitachi, Keisuke; Tsuchida, Kunihiro

2017-01-01

Myostatin, a member of the transforming growth factor-beta superfamily, is a negative regulator of skeletal muscle growth and development. Myostatin inhibition leads to increased skeletal muscle mass in mammals; hence, myostatin is considered a potential therapeutic target for skeletal muscle wasting. However, downstream molecules of myostatin in the skeletal muscle have not been fully elucidated. Here, we identified the Dlk1-Dio3 locus at the mouse chromosome 12qF1, also called as the callipyge locus in sheep, as a novel downstream target of myostatin. In skeletal muscle of myostatin knockout mice, the expression of mature miRNAs at the Dlk1-Dio3 locus was significantly increased. The increased miRNA levels are caused by the transcriptional activation of the Dlk1-Dio3 locus, because a significant increase in the primary miRNA transcript was observed in myostatin knockout mice. In addition, we found increased expression of coding and non-coding genes (Dlk1, Gtl2, Rtl1/Rtl1as, and Rian) at the Dlk1-Dio3 locus in myostatin-deficient skeletal muscle. Moreover, epigenetic changes, associated with the regulation of the Dlk1-Dio3 locus, were observed in myostatin knockout mice. Taken together, this is the first report demonstrating the role of myostatin in regulating the Dlk1-Dio3 (the callipyge) locus in the skeletal muscle. PMID:27992376

Myostatin-deficiency in mice increases global gene expression at the Dlk1-Dio3 locus in the skeletal muscle.

PubMed

Hitachi, Keisuke; Tsuchida, Kunihiro

2017-01-24

Myostatin, a member of the transforming growth factor-beta superfamily, is a negative regulator of skeletal muscle growth and development. Myostatin inhibition leads to increased skeletal muscle mass in mammals; hence, myostatin is considered a potential therapeutic target for skeletal muscle wasting. However, downstream molecules of myostatin in the skeletal muscle have not been fully elucidated. Here, we identified the Dlk1-Dio3 locus at the mouse chromosome 12qF1, also called as the callipyge locus in sheep, as a novel downstream target of myostatin. In skeletal muscle of myostatin knockout mice, the expression of mature miRNAs at the Dlk1-Dio3 locus was significantly increased. The increased miRNA levels are caused by the transcriptional activation of the Dlk1-Dio3 locus, because a significant increase in the primary miRNA transcript was observed in myostatin knockout mice. In addition, we found increased expression of coding and non-coding genes (Dlk1, Gtl2, Rtl1/Rtl1as, and Rian) at the Dlk1-Dio3 locus in myostatin-deficient skeletal muscle. Moreover, epigenetic changes, associated with the regulation of the Dlk1-Dio3 locus, were observed in myostatin knockout mice. Taken together, this is the first report demonstrating the role of myostatin in regulating the Dlk1-Dio3 (the callipyge) locus in the skeletal muscle.

Analyzing Reliability and Performance Trade-Offs of HLS-Based Designs in SRAM-Based FPGAs Under Soft Errors

NASA Astrophysics Data System (ADS)

Tambara, Lucas Antunes; Tonfat, Jorge; Santos, André; Kastensmidt, Fernanda Lima; Medina, Nilberto H.; Added, Nemitala; Aguiar, Vitor A. P.; Aguirre, Fernando; Silveira, Marcilei A. G.

2017-02-01

The increasing system complexity of FPGA-based hardware designs and shortening of time-to-market have motivated the adoption of new designing methodologies focused on addressing the current need for high-performance circuits. High-Level Synthesis (HLS) tools can generate Register Transfer Level (RTL) designs from high-level software programming languages. These tools have evolved significantly in recent years, providing optimized RTL designs, which can serve the needs of safety-critical applications that require both high performance and high reliability levels. However, a reliability evaluation of HLS-based designs under soft errors has not yet been presented. In this work, the trade-offs of different HLS-based designs in terms of reliability, resource utilization, and performance are investigated by analyzing their behavior under soft errors and comparing them to a standard processor-based implementation in an SRAM-based FPGA. Results obtained from fault injection campaigns and radiation experiments show that it is possible to increase the performance of a processor-based system up to 5,000 times by changing its architecture with a small impact in the cross section (increasing up to 8 times), and still increasing the Mean Workload Between Failures (MWBF) of the system.

Highly sensitive quantitation of pesticides in fruit juice samples by modeling four-way data gathered with high-performance liquid chromatography with fluorescence excitation-emission detection.

PubMed

Montemurro, Milagros; Pinto, Licarion; Véras, Germano; de Araújo Gomes, Adriano; Culzoni, María J; Ugulino de Araújo, Mário C; Goicoechea, Héctor C

2016-07-01

A study regarding the acquisition and analytical utilization of four-way data acquired by monitoring excitation-emission fluorescence matrices at different elution time points in a fast HPLC procedure is presented. The data were modeled with three well-known algorithms: PARAFAC, U-PLS/RTL and MCR-ALS, the latter conveniently adapted to model third-order data. The second-order advantage was exploited when analyzing samples containing uncalibrated components. The best results were furnished with the algorithm U-PLS/RTL. This fact is indicative of both no peak time shifts occurrence among samples and high colinearity among spectra. Besides, this latent-variable structured algorithm is capable of better handle the need of achieving high sensitivity for the analysis of one of the analytes. In addition, a significant enhancement in both predictions and analytical figures of merit was observed for carbendazim, thiabendazole, fuberidazole, carbofuran, carbaryl and 1-naphtol, when going from second- to third-order data. LODs obtained were ranged between 0.02 and 2.4μgL(-1). Copyright © 2016 Elsevier B.V. All rights reserved.

The radial transmission line as a broad-band shielded exposure system for microwave irradiation of large numbers of culture flasks.

PubMed

Moros, E G; Straube, W L; Pickard, W F

1999-01-01

The problem of simultaneously exposing large numbers of culture flasks at nominally equivalent incident power densities and with good thermal control is considered, and the radial transmission line (RTL) is proposed as a solution. The electromagnetic design of this structure is discussed, and an extensively bench-tested realization is described. Referred to 1 W of net forward power, the following specific absorption rate (SAR) data were obtained: at 835.62 MHz, 16.0+/-2.5 mW/kg (mean+/-SD) with range (11-22); at 2450 MHz, 245+/-50 mW/kg with range (130-323). Radio-frequency interference from an RTL driven at roughly 100 W is so low as to be compatible with a cellular base station only 500 m distant. To avoid potential confounding by temperature differences among as many as 144 T-75 flasks distributed over 9 RTLs (six irradiates and three shams), temperature within all flasks was controlled to 37.0+/-0.3 degrees C. Experience with over two years of trouble-free operation suggests that the RTL offers a robust, logistically friendly, and environmentally satisfactory solution to the problem of large-scale in vitro experiments in bioelectromagnetics.

Return to learn: Transitioning to school and through ascending levels of academic support for students following a concussion.

PubMed

McAvoy, Karen; Eagan-Johnson, Brenda; Halstead, Mark

2018-01-01

The purpose of this article is to familiarize healthcare providers and parents with educational language, laws, and processes as they relate to a comprehensive ascending level of academic supports as it pertains to promoting a smooth and supported transition to school following a concussion. Returning to learn (RTL) following a concussion is of parallel importance to returning to sport (RTS). A successful RTL is a critical part of concussion management. Many RTL articles advise healthcare providers and parents to request formalized educational supports, also known as Tier 2 or Tier 3 services, for children with concussion as they return to school. Premature requests for formal (Tier 2 or 3) educational services, rather than allowing for immediate informal educational supports (known as Tier 1), can actually delay academic supports and have the potential to cause adversarial relationships between parents and schools. Additionally, this practice contradicts current research demonstrating the need for fast, flexible, temporary academic supports within the first month post-injury. Allowing school districts to direct the application of existing ascending levels of educational support for students with concussion as they return to school can promote robust and positive outcomes.

Sex worker incarceration in the People's Republic of China.

PubMed

Tucker, J D; Ren, X

2008-02-01

Tens of thousands of commercial sex workers in China are administratively detained each year in female re-education through labor (RTL) centres for moral education and vocational training. Recent increases in syphilis and heterosexual HIV make tailored HIV prevention efforts for sex workers increasingly important in many regions of China. However, RTL centres focused on detaining commercial sex workers have not traditionally been linked to sexually transmitted infections (STI)/HIV programmes. The stigma of being incarcerated and selling sex complicates STI/HIV prevention for these women. Incarcerated sex workers represent a particularly marginalized HIV risk group that has been excluded from domestic and international HIV programmes to date. Although several laws and administrative decrees provide a legal mandate for sex worker STI/HIV testing, treatment and rights, there is still substantial variation in how laws are implemented. Creating devoted medical services and legal aid for incarcerated sex workers is important in curbing the spread of heterosexual HIV and other STIs in China. Recent legal and social developments suggest that China's RTL system will be transformed in the near future, gaining momentum for reform that could improve the sexual and human rights of incarcerated sex workers.

One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation.

PubMed

Pusceddu, Irene; Herrmann, Markus; Kirsch, Susanne H; Werner, Christian; Hübner, Ulrich; Bodis, Marion; Laufs, Ulrich; Widmann, Thomas; Wagenpfeil, Stefan; Geisel, Jürgen; Herrmann, Wolfgang

2017-08-01

Vitamin B deficiency is common in elderly people and has been associated with an increased risk of developing age-related diseases. B-vitamins are essential for the synthesis and stability of DNA. Telomers are the end caps of chromosomes that shorten progressively with age, and short telomers are associated with DNA instability. In the present randomized intervention study, we investigated whether the one-carbon metabolism is related to telomere length, a surrogate marker for cellular aging. Sixty-five subjects (>54 years) were randomly assigned to receive either a daily combination of vitamin D3 (1200 IU), folic acid (0.5 mg), vitamin B 12 (0.5 mg), vitamin B 6 (50 mg) and calcium carbonate (456 mg) (group A) or vitamin D3 and calcium carbonate alone (group B). Blood testing was performed at baseline and after 1 year of supplementation. The concentrations of several metabolites of the one-carbon pathway, as well as relative telomere length (RTL) and 5,10-methylenetetrahydrofolate reductase C677T genotype, were analyzed. At baseline, age- and gender-adjusted RTL correlated with total folate and 5-methyltetrahydrofolate (5-methylTHF). Subjects with RTL above the median had higher concentrations of total folate and 5-methylTHF compared to subjects below the median. At study end, gender- and age-adjusted RTL correlated in group A with methylmalonic acid (MMA; r = -0.460, p = 0.0012) and choline (r = 0.434, p = 0.0021) and in group B with 5,10-methenyltetrahydrofolate (r = 0.455, p = 0.026) and dimethylglycine (DMG; r = -0.386, p = 0.047). Subjects in the group A with RTL above the median had lower MMA and higher choline compared to subjects below the median. The present pilot study suggests a functional relationship between one-carbon metabolism and telomere length. This conclusion is supported by several correlations that were modified by B-vitamin supplementation. In agreement with our hypothesis, the availability of nucleotides and methylation groups seems to impact telomere length. Due to the small sample size and the limitations of the study, further studies should confirm the present results in a larger cohort.

Telomere length in children environmentally exposed to low-to-moderate levels of lead

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pawlas, Natalia, E-mail: n-pawlas@wp.pl; Płachetka, Anna; Kozłowska, Agnieszka

Shorter relative telomere length in peripheral blood is a risk marker for some types of cancers and cardiovascular diseases. Several environmental hazards appear to shorten telomeres, and this shortening may predispose individuals to disease. The aim of the present cross-sectional study was to assess the effect of environmental exposure to lead on relative telomere length (rTL) in children. A cohort of 99 8-year-old children was enrolled from 2007–2010. Blood lead concentrations (B-Pb) were measured by graphite furnace atomic absorption spectrometry, and blood rTL was measured by quantitative PCR. The geometric mean of B-Pb was 3.28 μg/dl (range: 0.90–14.2), and themore » geometric mean of rTL was 1.08 (range: 0.49–2.09). B-Pb was significantly inversely associated with rTL in the children (r{sub S} = − 0.25, p = 0.013; in further analyses both log-transformed-univariate regression analysis β = − 0.13, p = 0.026, and R{sup 2}adj 4%; and β = − 0.12, p = 0.056 when adjusting for mothers' smoking during pregnancy, Apgar score, mother's and father's ages at delivery, sex and mother's education, R{sup 2}adj 12%, p = 0.011). The effect of lead remained significant in children without prenatal tobacco exposure (N = 87, r{sub S} = − 0.24, p = 0.024; in further analyses, β = − 0.13, p = 0.029, and R{sup 2}adj 4%). rTL was not affected by sex, the concentrations of other elements in the blood (i.e., cadmium and selenium concentrations), or oxidative injury parameters (total antioxidant status, 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances). Lead exposure in childhood appears to be associated with shorter telomeres, which might contribute to diseases, such as cardiovascular disease. The inverse association between blood lead level and the telomeres in children emphasizes the importance of further reducing lead levels in the environment. - Highlights: • This cross-sectional study analyzes the association between environmental lead exposure and telomere length in children. • Blood lead concentrations were inversely associated with relative telomere length in 8-year-old children. • Environmental lead exposure during childhood might contribute to telomere shortening, and in turn, future risk for disease.« less

A Comparative Study of Soviet versus Western Helicopters. Part 2. Evaluation of Weight, Maintainability, and Design Aspects of Major Components

DTIC Science & Technology

1983-03-01

transmnission ratingob gearbox ult uldiatc gOr tail-rotor gearbox Vr vertical tailh hub w wheelhr horizontal tail w/ wheel -type landing-gear legslob...depends on ýhe type of landing gear (skid, fixed- wheel , or retractable). The RTL approach takes into consideration not only gross weight, but also...depending on the helicopter configuration (single- rotor, tandem, or side-by-side), and the type of landing gear ( wheel or skid). For a single-rotor

Association of plant growth-promoting Serratia spp. with the root nodules of chickpea.

PubMed

Zaheer, Ahmad; Mirza, Babur S; Mclean, Joan E; Yasmin, Sumera; Shah, Tariq Mahmud; Malik, Kauser A; Mirza, M Sajjad

2016-01-01

Serratia species-affiliated DNA sequences have recently been discovered in the root nodules of two chickpea cultivars; however, little is known about their potential influence on chickpea plant growth. All Serratia-affiliated sequences (1136) could be grouped into two clusters at 98% DNA similarity. The major cluster, represented by 96% of sequences, was closely associated with Serratia marcescens sequences from GenBank. In the current study, we isolated two Serratia strains, 5D and RTL100, from root nodules of a field-grown Desi cultivar from Faisalabad and Thal areas, respectively. In vitro, strain 5D showed significantly higher phosphate (P) solubilization and lactic acid production than RTL100, whereas a comparable concentration of phytohormone was produced by both isolates. The application of Serratia strain 5D as an inoculum resulted in 25.55% and 30.85% increases in the grain yield of crops grown on fertile soil in irrigated areas and nutrient-deficient soil in rainfed areas, respectively, compared to the non-inoculated control. Results of plant inoculations indicated that Serratia sp. 5D and RTL100 can serve as effective microbial inoculants, particularly in nutrient-deficient soils in rainfed areas, where chickpea is the only major crop grown during the entire year. Copyright © 2016 Institut Pasteur. All rights reserved.

Health and human rights concerns of drug users in detention in Guangxi Province, China.

PubMed

Cohen, J Elizabeth; Amon, Joseph J

2008-12-09

Although confinement in drug detoxification ("detox") and re-education through labor (RTL) centers is the most common form of treatment for drug dependence in China, little has been published about the experience of drug users in such settings. We conducted an assessment of the impact of detention on drug users' access to HIV prevention and treatment services and consequent threats to fundamental human rights protections. Chinese government HIV and anti-narcotics legislation and policy documents were reviewed, and in-depth and key informant interviews were conducted with 19 injection drug users (IDUs) and 20 government and nongovernmental organization officials in Nanning and Baise, Guangxi Province. Significant contradictions were found in HIV and antinarcotics policies, exemplified by the simultaneous expansion of community-based methadone maintenance therapy and the increasing number of drug users detained in detox and RTL center facilities. IDU study participants reported, on average, having used drugs for 14 y (range 8-23 y) and had been confined to detox four times (range one to eight times) and to RTL centers once (range zero to three times). IDUs expressed an intense fear of being recognized by the police and being detained, regardless of current drug use. Key informants and IDUs reported that routine HIV testing, without consent and without disclosure of the result, was the standard policy of detox and RTL center facilities, and that HIV-infected detainees were not routinely provided medical or drug dependency treatment, including antiretroviral therapy. IDUs received little or no information or means of HIV prevention, but reported numerous risk behaviors for HIV transmission while detained. Legal and policy review, and interviews with recently detained IDUs and key informants in Guangxi Province, China, found evidence of anti-narcotics policies and practices that appear to violate human rights and imperil drug users' health.

Health and Human Rights Concerns of Drug Users in Detention in Guangxi Province, China

PubMed Central

Cohen, J. Elizabeth; Amon, Joseph J

2008-01-01

Background Although confinement in drug detoxification (“detox”) and re-education through labor (RTL) centers is the most common form of treatment for drug dependence in China, little has been published about the experience of drug users in such settings. We conducted an assessment of the impact of detention on drug users' access to HIV prevention and treatment services and consequent threats to fundamental human rights protections. Methods and Findings Chinese government HIV and anti-narcotics legislation and policy documents were reviewed, and in-depth and key informant interviews were conducted with 19 injection drug users (IDUs) and 20 government and nongovernmental organization officials in Nanning and Baise, Guangxi Province. Significant contradictions were found in HIV and antinarcotics policies, exemplified by the simultaneous expansion of community-based methadone maintenance therapy and the increasing number of drug users detained in detox and RTL center facilities. IDU study participants reported, on average, having used drugs for 14 y (range 8–23 y) and had been confined to detox four times (range one to eight times) and to RTL centers once (range zero to three times). IDUs expressed an intense fear of being recognized by the police and being detained, regardless of current drug use. Key informants and IDUs reported that routine HIV testing, without consent and without disclosure of the result, was the standard policy of detox and RTL center facilities, and that HIV-infected detainees were not routinely provided medical or drug dependency treatment, including antiretroviral therapy. IDUs received little or no information or means of HIV prevention, but reported numerous risk behaviors for HIV transmission while detained. Conclusions Legal and policy review, and interviews with recently detained IDUs and key informants in Guangxi Province, China, found evidence of anti-narcotics policies and practices that appear to violate human rights and imperil drug users' health. PMID:19071954

A novel optimised and validated method for analysis of multi-residues of pesticides in fruits and vegetables by microwave-assisted extraction (MAE)-dispersive solid-phase extraction (d-SPE)-retention time locked (RTL)-gas chromatography-mass spectrometry with Deconvolution reporting software (DRS).

PubMed

Satpathy, Gouri; Tyagi, Yogesh Kumar; Gupta, Rajinder Kumar

2011-08-01

A rapid, effective and ecofriendly method for sensitive screening and quantification of 72 pesticides residue in fruits and vegetables, by microwave-assisted extraction (MAE) followed by dispersive solid-phase extraction (d-SPE), retention time locked (RTL) capillary gas-chromatographic separation in trace ion mode mass spectrometric determination has been validated as per ISO/IEC: 17025:2005. Identification and reporting with total and extracted ion chromatograms were facilitated to a great extent by Deconvolution reporting software (DRS). For all compounds LOD were 0.002-0.02mg/kg and LOQ were 0.025-0.100mg/kg. Correlation coefficients of the calibration curves in the range of 0.025-0.50mg/kg were >0.993. To validate matrix effects repeatability, reproducibility, recovery and overall uncertainty were calculated for the 35 matrices at 0.025, 0.050 and 0.100mg/kg. Recovery ranged between 72% and 114% with RSD of <20% for repeatability and intermediate precision. The reproducibility of the method was evaluated by an inter laboratory participation and Z score obtained within ±2. Copyright © 2011 Elsevier Ltd. All rights reserved.

Integrated circuit test-port architecture and method and apparatus of test-port generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teifel, John

A method and apparatus are provided for generating RTL code for a test-port interface of an integrated circuit. In an embodiment, a test-port table is provided as input data. A computer automatically parses the test-port table into data structures and analyzes it to determine input, output, local, and output-enable port names. The computer generates address-detect and test-enable logic constructed from combinational functions. The computer generates one-hot multiplexer logic for at least some of the output ports. The one-hot multiplexer logic for each port is generated so as to enable the port to toggle between data signals and test signals. Themore » computer then completes the generation of the RTL code.« less

Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy

PubMed Central

Dotson, Abby L.; Zhu, Wenbin; Libal, Nicole; Alkayed, Nabil J.; Offner, Halina

2014-01-01

Stroke is a leading cause of death and disability in the United States. The lack of clinical success in stroke therapies can be attributed, in part, to inadequate basic research on aging rodents. The current study demonstrates that recombinant TCR ligand therapy uses different immunological mechanisms to protect young and older mice from experimental stroke. In young mice, RTL1000 therapy inhibited splenocyte efflux while reducing frequency of T cells and macrophages in the spleen. Older mice treated with RTL1000 exhibited a significant reduction in inflammatory cells in the brain and inhibition of splenic atrophy. Our data suggest age specific differences in immune response to stroke that allow unique targeting of stroke immunotherapies. PMID:25309326

Is telomere length a molecular marker of past thermal stress in wild fish?

PubMed

Debes, Paul V; Visse, Marko; Panda, Bineet; Ilmonen, Petteri; Vasemägi, Anti

2016-11-01

Telomeres protect eukaryotic chromosomes; variation in telomere length has been linked (primarily in homoeothermic animals) to variation in stress, cellular ageing and disease risk. Moreover, telomeres have been suggested to function as biomarker for quantifying past environmental stress, but studies in wild animals remain rare. Environmental stress, such as extreme environmental temperatures in poikilothermic animals, may result in oxidative stress that accelerates telomere attrition. However, growth, which may depend on temperature, can also contribute to telomere attrition. To test for associations between multitissue telomere length and past water temperature while accounting for the previous individual growth, we used quantitative PCR to analyse samples from 112 young-of-the-year brown trout from 10 natural rivers with average water temperature differences of up to 6°C (and an absolute maximum of 23°C). We found negative associations between relative telomere length (RTL) and both average river temperature and individual body size. We found no indication of RTL-temperature association differences among six tissues, but we did find indications for differences among the tissues for associations between RTL and body size; size trends, albeit nonsignificant in their differences, were strongest in muscle and weakest in fin. Although causal relationships among temperature, growth, oxidative stress, and cross-sectional telomere length remain largely unknown, our results indicate that telomere-length variation in a poikilothermic wild animal is associated with both past temperature and growth. © 2016 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd.

Famous faces and voices: Differential profiles in early right and left semantic dementia and in Alzheimer's disease.

PubMed

Luzzi, Simona; Baldinelli, Sara; Ranaldi, Valentina; Fabi, Katia; Cafazzo, Viviana; Fringuelli, Fabio; Silvestrini, Mauro; Provinciali, Leandro; Reverberi, Carlo; Gainotti, Guido

2017-01-08

Famous face and voice recognition is reported to be impaired both in semantic dementia (SD) and in Alzheimer's Disease (AD), although more severely in the former. In AD a coexistence of perceptual impairment in face and voice processing has also been reported and this could contribute to the altered performance in complex semantic tasks. On the other hand, in SD both face and voice recognition disorders could be related to the prevalence of atrophy in the right temporal lobe (RTL). The aim of the present study was twofold: (1) to investigate famous faces and voices recognition in SD and AD to verify if the two diseases show a differential pattern of impairment, resulting from disruption of different cognitive mechanisms; (2) to check if face and voice recognition disorders prevail in patients with atrophy mainly affecting the RTL. To avoid the potential influence of primary perceptual problems in face and voice recognition, a pool of patients suffering from early SD and AD were administered a detailed set of tests exploring face and voice perception. Thirteen SD (8 with prevalence of right and 5 with prevalence of left temporal atrophy) and 25 CE patients, who did not show visual and auditory perceptual impairment, were finally selected and were administered an experimental battery exploring famous face and voice recognition and naming. Twelve SD patients underwent cerebral PET imaging and were classified in right and left SD according to the onset modality and to the prevalent decrease in FDG uptake in right or left temporal lobe respectively. Correlation of PET imaging and famous face and voice recognition was performed. Results showed a differential performance profile in the two diseases, because AD patients were significantly impaired in the naming tests, but showed preserved recognition, whereas SD patients were profoundly impaired both in naming and in recognition of famous faces and voices. Furthermore, face and voice recognition disorders prevailed in SD patients with RTL atrophy, who also showed a conceptual impairment on the Pyramids and Palm Trees test more important in the pictorial than in the verbal modality. Finally, in 12SD patients in whom PET was available, a strong correlation between FDG uptake and face-to-name and voice-to-name matching data was found in the right but not in the left temporal lobe. The data support the hypothesis of a different cognitive basis for impairment of face and voice recognition in the two dementias and suggest that the pattern of impairment in SD may be due to a loss of semantic representations, while a defect of semantic control, with impaired naming and preserved recognition might be hypothesized in AD. Furthermore, the correlation between face and voice recognition disorders and RTL damage are consistent with the hypothesis assuming that in the RTL person-specific knowledge may be mainly based upon non-verbal representations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Seismicity Pattern Changes before the M = 4.8 Aeolian Archipelago (Italy) Earthquake of August 16, 2010

PubMed Central

2014-01-01

We investigated the seismicity patterns associated with an M = 4.8 earthquake recorded in the Aeolian Archipelago on 16, August, 2010, by means of the region-time-length (RTL) algorithm. This earthquake triggered landslides at Lipari; a rock fall on the flanks of the Vulcano, Lipari, and Salina islands, and some damages to the village of Lipari. The RTL algorithm is widely used for investigating precursory seismicity changes before large and moderate earthquakes. We examined both the spatial and temporal characteristics of seismicity changes in the Aeolian Archipelago region before the M = 4.8 earthquake. The results obtained reveal 6-7 months of seismic quiescence which started about 15 months before the earthquake. The spatial distribution shows an extensive area characterized by seismic quiescence that suggests a relationship between quiescence and the Aeolian Archipelago regional tectonics. PMID:24511288

FPGA implementation of predictive degradation model for engine oil lifetime

NASA Astrophysics Data System (ADS)

Idros, M. F. M.; Razak, A. H. A.; Junid, S. A. M. Al; Suliman, S. I.; Halim, A. K.

2018-03-01

This paper presents the implementation of linear regression model for degradation prediction on Register Transfer Logic (RTL) using QuartusII. A stationary model had been identified in the degradation trend for the engine oil in a vehicle in time series method. As for RTL implementation, the degradation model is written in Verilog HDL and the data input are taken at a certain time. Clock divider had been designed to support the timing sequence of input data. At every five data, a regression analysis is adapted for slope variation determination and prediction calculation. Here, only the negative value are taken as the consideration for the prediction purposes for less number of logic gate. Least Square Method is adapted to get the best linear model based on the mean values of time series data. The coded algorithm has been implemented on FPGA for validation purposes. The result shows the prediction time to change the engine oil.

Control structures for high speed processors

NASA Technical Reports Server (NTRS)

Maki, G. K.; Mankin, R.; Owsley, P. A.; Kim, G. M.

1982-01-01

A special processor was designed to function as a Reed Solomon decoder with throughput data rate in the Mhz range. This data rate is significantly greater than is possible with conventional digital architectures. To achieve this rate, the processor design includes sequential, pipelined, distributed, and parallel processing. The processor was designed using a high level language register transfer language. The RTL can be used to describe how the different processes are implemented by the hardware. One problem of special interest was the development of dependent processes which are analogous to software subroutines. For greater flexibility, the RTL control structure was implemented in ROM. The special purpose hardware required approximately 1000 SSI and MSI components. The data rate throughput is 2.5 megabits/second. This data rate is achieved through the use of pipelined and distributed processing. This data rate can be compared with 800 kilobits/second in a recently proposed very large scale integration design of a Reed Solomon encoder.

Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy

PubMed Central

Xu, Xuewen; Ectors, Fabien; Davis, Erica E.; Pirottin, Dimitri; Cheng, Huijun; Farnir, Frédéric; Hadfield, Tracy; Cockett, Noelle; Charlier, Carole; Georges, Michel; Takeda, Haruko

2015-01-01

The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous + Mat /CLPG Pat animals receiving the CLPG mutation from their father express the phenotype. + Mat /CLPG Pat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep. PMID:26474044

Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and São Paulo, Brazil

PubMed Central

2013-01-01

Background Continuous long-term treatment is recommended to reduce the hepatitis B virus (HBV) viral load. However, as a consequence, resistance mutations can emerge and be transmitted to other individuals. The polymerase (POL) gene overlaps the surface (S) gene. Thus, during treatment, mutations in the POL gene may lead to changes in hepatitis B surface antigen (HBsAg). The purpose of this study was to evaluate the frequency of lamivudine and vaccine escape mutations in HBsAg-positive blood donors from the city of Santos and in untreated HBV mono-infected patients from the city of São Paulo, Brazil. Methods HBV DNA was extracted from 80 serum samples, of which 61 were from volunteer blood donors and 19 were from untreated HBV patients. A fragment of the POL/S genes containing 593 base pairs was amplified using nested PCR. Thirty four were PCR-positive and sequencing was performed using an ABI Prism 3130 Genetic Analyzer. Alignments and mutation mapping were performed using BioEdit software. Results HBV DNA from 21 blood donors and 13 untreated patient samples were characterized using nucleotide sequencing PCR products from the POL/S genes. We were able to detect one sample with the resistance mutation to lamivudine rtM204V + rtL180M (2.94%), which was found in a volunteer blood donor that has never used antiviral drugs. The other samples showed only compensatory mutations, such as rtL80F (5.88%), rtL80V (2.94%), rtL82V + rtV207L (2.94%), rtT128P (5.88%), rtT128N/S (2.94%) and rtS219A (5.88%). We found modifications in the S gene in 14 of the 34 samples (41.16%). The mutations detected were as follows: sM133L + sI195T (2.94%), sI195M (2.94%), sP120T (2.94%), sY100S/F (2.94%), sY100C (17.64%), sI/T126P + sQ129P (2.94%), sM198I + sF183C (2.94%) and sS210R (5.88%). Conclusions Our results suggest the transmission of lamivudine-resistant forms. Thus, the evaluation of HBV-infected subjects for lamivudine resistance would improve treatment regime. Moreover, the mutations in the S gene may impair HBsAg antigenicity and contribute to HBsAg failure detection and vaccine escape. PMID:24165277

Telomere length in Chernobyl accident recovery workers in the late period after the disaster.

PubMed

Reste, Jelena; Zvigule, Gunda; Zvagule, Tija; Kurjane, Natalja; Eglite, Maija; Gabruseva, Natalija; Berzina, Dace; Plonis, Juris; Miklasevics, Edvins

2014-11-01

The outcome of the Chernobyl nuclear power plant (CNPP) accident was that a huge number of people were exposed to ionizing radiation. Previous studies of CNPP clean-up workers from Latvia revealed a high occurrence of age-associated degenerative diseases and cancer in young adults, as well as a high mortality as a result of cardiovascular disorders at age 45-54 years. DNA tandem repeats that cap chromosome ends, known as telomeres, are sensitive to oxidative damage and exposure to ionizing radiation. Telomeres are important in aging processes and carcinogenesis. The aim of this study was to investigate the long-term effect of protracted ionizing radiation exposure on telomere length in CNPP clean-up workers. Relative telomere length (RTL) was measured in peripheral blood leukocytes of 595 CNPP clean-up workers and 236 gender- and age-matched controls using real-time quantitative polymerase chain reaction (q-PCR). Close attention was paid to participation year and tasks performed during the worker's stay in Chernobyl, health status, and RTL differences between subgroups. Telomere shortening was not found in CNPP clean-up workers; on the contrary, their RTL was slightly greater than in controls (P = 0.001). Longer telomeres were found in people who worked during 1986, in those undertaking 'dirty' tasks (digging and deactivation), and in people with cancer. Shorter telomeres appeared frequently in those with cataract, osteoporosis, atherosclerosis, or coronary heart disease. We conclude that the longer telomeres revealed in people more heavily exposed to ionizing radiation probably indicate activation of telomerase as a chromosome healing mechanism following damage, and reflect defects in telomerase regulation that could potentiate carcinogenesis. © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

Telomere length in Chernobyl accident recovery workers in the late period after the disaster

PubMed Central

Reste, Jelena; Zvigule, Gunda; Zvagule, Tija; Kurjane, Natalja; Eglite, Maija; Gabruseva, Natalija; Berzina, Dace; Plonis, Juris; Miklasevics, Edvins

2014-01-01

The outcome of the Chernobyl nuclear power plant (CNPP) accident was that a huge number of people were exposed to ionizing radiation. Previous studies of CNPP clean-up workers from Latvia revealed a high occurrence of age-associated degenerative diseases and cancer in young adults, as well as a high mortality as a result of cardiovascular disorders at age 45–54 years. DNA tandem repeats that cap chromosome ends, known as telomeres, are sensitive to oxidative damage and exposure to ionizing radiation. Telomeres are important in aging processes and carcinogenesis. The aim of this study was to investigate the long-term effect of protracted ionizing radiation exposure on telomere length in CNPP clean-up workers. Relative telomere length (RTL) was measured in peripheral blood leukocytes of 595 CNPP clean-up workers and 236 gender- and age-matched controls using real-time quantitative polymerase chain reaction (q-PCR). Close attention was paid to participation year and tasks performed during the worker's stay in Chernobyl, health status, and RTL differences between subgroups. Telomere shortening was not found in CNPP clean-up workers; on the contrary, their RTL was slightly greater than in controls (P = 0.001). Longer telomeres were found in people who worked during 1986, in those undertaking ‘dirty’ tasks (digging and deactivation), and in people with cancer. Shorter telomeres appeared frequently in those with cataract, osteoporosis, atherosclerosis, or coronary heart disease. We conclude that the longer telomeres revealed in people more heavily exposed to ionizing radiation probably indicate activation of telomerase as a chromosome healing mechanism following damage, and reflect defects in telomerase regulation that could potentiate carcinogenesis. PMID:25015931

Genetic variants affecting telomere length are associated with the prognosis of esophageal squamous cell carcinoma in a Chinese population.

PubMed

Lu, Yue; Yan, Caiwang; Du, Jiangbo; Ji, Yong; Gao, Yong; Zhu, Xun; Yu, Fei; Huang, Tongtong; Dai, Juncheng; Ma, Hongxia; Jiang, Yue; Chen, Jiaping; Shen, Hongbing; Jin, Guangfu; Yin, Yongmei; Hu, Zhibin

2017-03-01

Telomeres are essential for maintaining chromosomal stability and are crucial in tumor progression. Previous studies have explored the associations between telomere length and cancer prognosis, but the findings are inconclusive. Genome-wide association studies have identified several genetic variants associated with telomere length in Caucasians. However, the roles of telomere length and related genetic variants on esophageal squamous cell carcinoma (ESCC) prognosis are largely unknown. Therefore, we conducted a case-cohort study with 431 ESCC patients to assess the associations between relative telomere length (RTL), eight known telomere length related variants and the overall survival of ESCC in Chinese population. We found that as compared with the reference group, patients in the fifth (the longest) quintile had a significantly better prognosis [(adjusted hazard ratio (HR) = 0.58, 95% confidence interval (CI) = 0.34-0.98, P = 0.041]. Furthermore, A allele of rs2736108 was significantly associated with both the increased RTL (P = 0.048) and the better prognosis of ESCC (adjusted HR = 0.55, 95%CI = 0.38-0.79, P = 1.31 × 10 -3 ). Mediation analysis indicated that the effect of rs2736108 on ESCC prognosis was partly explained by RTL (1.99%). Stepwise Cox proportional hazard analysis suggested that rs2736108 played an important protective role in ESCC prognosis (HR = 0.57, 95%CI = 0.40-0.81, P = 1.97 × 10 - 3 ). Our findings provide evidence that prolonged telomere length is a protective factor for ESCC patients' survival and the known telomere length related genetic variant rs2736108 can contribute to the prognosis of ESCC as well in Chinese population. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

U.S. EPA, Pesticide Product Label, 5% SEVIN DUST, 11/13/1972

EPA Pesticide Factsheets

2011-04-14

... 1 , j.1 , ,! , ~ I II r 1 \\ 1 '- l) I' I .Il I l () I' ,_ II \\" , lI, qom,lI(·j'" ... 1.1111 p\\'Plhf.., ! .ll,} .I,.!,' I • . : , • 1 P "" l,'rtl;,' 1,1,.,1 11"1')' ill!TI'I) IJfl('" .. ...

Implicit and Explicit Memory for Affective Passages in Temporal Lobectomy Patients

ERIC Educational Resources Information Center

Burton, Leslie A.; Rabin, Laura; Vardy, Susan Bernstein; Frohlich, Jonathan; Porter, Gwinne Wyatt; Dimitri, Diana; Cofer, Lucas; Labar, Douglas

2008-01-01

Eighteen temporal lobectomy patients (9 left, LTL; 9 right, RTL) were administered four verbal tasks, an Affective Implicit Task, a Neutral Implicit Task, an Affective Explicit Task, and a Neutral Explicit Task. For the Affective and Neutral Implicit Tasks, participants were timed while reading aloud passages with affective or neutral content,…

U.S. EPA, Pesticide Product Label, MAB-250, 04/23/1985

EPA Pesticide Factsheets

2011-04-21

... ': (./ _.1" :--- Ic,;d -".n r.. f'. r"~tl11"" rn)(~lH'-t: ,~an.:'\\qPl (17) ~iSl nfpC'tf1.nt q Brand' pr"Ql!--f-rr-ttl'''JI l\\iVl~:l(\\r' rTS-/fll(') J: ~ .. T .~~,~t ~IJ~~ j ...

Evaluation of genotoxic and cytotoxic properties of pesticides employed in Italian agricultural practices.

PubMed

De Marco, A; De Salvia, R; Polani, S; Ricordy, R; Sorrenti, F; Perticone, P; Cozzi, R; D'Ambrosio, C; De Simone, C; Guidotti, M; Albanesi, T; Duranti, G; Festa, F; Gensabella, G; Owczarek, M

2000-07-01

In a program coordinated by the Italian Ministry of Works, we tested in vitro four pesticides widely employed in a developed agricultural region of central Italy. The four commercial agents were chosen on the basis of their diffusion in agricultural practice, knowledge of their active principle(s), and scant availability of data concerning their toxic and genotoxic activity. The agents were Cirtoxin, Decis, Tramat Combi (TC), and Lasso Micromix (LM). All substances were tested in three in vitro systems: Chinese hamster ovary (CHO) cells, a metabolically competent hamster cell line (Chinese hamster epithelial liver; CHEL), and root tips of Vicia faba (VF). The cytotoxic and genotoxic end points challenged were micronuclei and root tip length (RTL) in VF and mitotic index (MI), proliferation index (PI), cell survival (CS), cell growth (CG), cell cycle length (CCL), sister chromatid exchanges, chromosomal aberrations, and single-cell gel electrophoresis, or comet assay, in CHEL and CHO cells. Tested doses ranged from the field dose up to 200x the field dose to take into account accumulation effects. On the whole, tested agents appear to induce genotoxic damage only at subtoxic or toxic doses, indicating a low clastogenic risk. MI, PI, CS, CG, RTL, and CCL appear to be the less sensitive end points, showing no effects in the presence of a clear positive response in some or all of the other tests. Using cytogenetic tests, we obtained positive results for TC and LM treatments in CHO but not in CHEL cells. These data could be accounted for by postulating a detoxifying activity exerted by this cell line. However, cytogenetic end points appear to be more sensitive than those referring to cytotoxicity.

U.S. EPA, Pesticide Product Label, AGWAY BETASAN 12.5G, 11/29/1979

EPA Pesticide Factsheets

2011-04-21

... i"'n"'rtl'll' ',',l,-jIf)I,,'; N;If""""' 1"'"11'" Mflll1,f'''''V t:vl't."." M,II'If'''''V Pm,. M~,'I,. f'nvt" f'hvp,.n'·jll" It,. !"I;ml r" raf"l'v"""d,;l rlnd ;'WI,,.t I'. 1 W."lllrlfl, .... 71111111' ...

Receiver Operating Characteristic Curve Analysis of Wechsler Memory Scale-Revised Scores in Epilepsy Surgery Candidates.

ERIC Educational Resources Information Center

Barr, William B.

1997-01-01

Wechsler Memory Scale-Revised (WMS-R) scores were analyzed for 82 epilepsy surgery candidates and used in combination with receiver operating characteristic curves to classify patients with left (LTL) and right (RTL) temporal lobe seizure onset. Results indicate that WMS-R scores used alone or in combination provide relatively poor discrimination…

U.S. EPA, Pesticide Product Label, SELCO MALATHION 55 EMULSIFIABLE, 12/11/1973

EPA Pesticide Factsheets

2011-04-14

... 1 .'1 (''''11' t ",:11 'K.". e)es aud c1Vt!liu&. 1\\t'l.·P out of ftach "f ,·i.ildrl'1I nl.d tic nI'S',,' a:.:III .• I, \\\\ H.,I. :1,or"UII',,) .11: •. '(J •• 1111'< lIat.'f ~rtl'r Ubillg. ...

In vitro evaluation of cellular responses induced by ZnO nanoparticles, zinc ions and bulk ZnO in fish cells.

PubMed

Fernández, Dolores; García-Gómez, Concepción; Babín, Mar

2013-05-01

Zinc oxide nanoparticles (ZnO-NPs) are inevitably released into the environment and are potentially dangerous for aquatic life. However, the potential mechanisms of cytotoxicity of zinc nanoparticles remain unclear. Studying the toxicity of ZnO-NPs with In vitro systems will help to determine their interactions with cellular biomolecules. The aim of this study was to evaluate the cytotoxic potentials of ZnO-NPs in established fish cell lines (RTG-2, RTH-149 and RTL-W1) and compare them with those of bulk ZnO and Zn(2+) ions. Membrane function (CFDA-AM assay), mitochondrial function (MTT assay), cell growth (KBP assay), cellular stress (β-galactosidase assay), reductase enzyme activity (AB assay), reactive oxygen species (ROS), total glutathione cellular content (tGSH assay) and glutathione S-transferase (GST) activities were assessed for all cell lines. ZnO-NPs cytotoxicity was greater than those of bulk ZnO and Zn(2+). ZnO-NPs induced oxidative stress is dependent on their dose. Low cost tests, such as CFDA-AM, ROS, GST activity and tGSH cell content test that use fish cell lines, may be used to detect oxidative stress and redox status changes. Particle dissolution of the ZnO-NPs did not appear to play an important role in the observed toxicity in this study. Published by Elsevier B.V.

Automated Design of Board and MCM Level Digital Systems.

DTIC Science & Technology

1997-10-01

Partitioning for Multicomponent Synthesis 159 Appendix K: Resource Constrained RTL Partitioning for Synthesis of Multi- FPGA Designs 169 Appendix L...digital signal processing) ar- chitectures. These target architectures, illustrated in Figure 1, can contain application-specific ASICS, FPGAs ...synthesis tools for ASIC, FPGA and MCM synthesis (Figure 8). Multicomponent Partitioning Engine The par- titioning engine is a hierarchical partitioning

The Effects of Parent-Focused Slow Relaxed Speech Intervention on Articulation Rate, Response Time Latency, and Fluency in Preschool Children Who Stutter

ERIC Educational Resources Information Center

Sawyer, Jean; Matteson, Colleen; Ou, Hua; Nagase, Takahisa

2017-01-01

Purpose: This study investigated the effects of an intervention to reduce caregivers' articulation rates with children who stutter on (a) disfluency, (b) caregiver and child's articulation rates, and (c) caregiver and child's response time latency (RTL). Method: Seventeen caregivers and their preschool children who stuttered participated in a…

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Science.gov Websites

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RTL validation methodology on high complexity wireless microcontroller using OVM technique for fast time to market

NASA Astrophysics Data System (ADS)

Zhafirah Muhammad, Nurul; Harun, A.; Hambali, N. A. M. A.; Murad, S. A. Z.; Mohyar, S. N.; Isa, M. N.; Jambek, AB

2017-11-01

Increased demand in internet of thing (IOT) application based has inadvertently forced the move towards higher complexity of integrated circuit supporting SoC. Such spontaneous increased in complexity poses unequivocal complicated validation strategies. Hence, the complexity allows researchers to come out with various exceptional methodologies in order to overcome this problem. This in essence brings about the discovery of dynamic verification, formal verification and hybrid techniques. In reserve, it is very important to discover bugs at infancy of verification process in (SoC) in order to reduce time consuming and fast time to market for the system. Ergo, in this paper we are focusing on the methodology of verification that can be done at Register Transfer Level of SoC based on the AMBA bus design. On top of that, the discovery of others verification method called Open Verification Methodology (OVM) brings out an easier way in RTL validation methodology neither as the replacement for the traditional method yet as an effort for fast time to market for the system. Thus, the method called OVM is proposed in this paper as the verification method for larger design to avert the disclosure of the bottleneck in validation platform.

Introduction of functionality, selection of topology, and enhancement of gas adsorption in multivariate metal-organic framework-177.

PubMed

Zhang, Yue-Biao; Furukawa, Hiroyasu; Ko, Nakeun; Nie, Weixuan; Park, Hye Jeong; Okajima, Satoshi; Cordova, Kyle E; Deng, Hexiang; Kim, Jaheon; Yaghi, Omar M

2015-02-25

Metal-organic framework-177 (MOF-177) is one of the most porous materials whose structure is composed of octahedral Zn4O(-COO)6 and triangular 1,3,5-benzenetribenzoate (BTB) units to make a three-dimensional extended network based on the qom topology. This topology violates a long-standing thesis where highly symmetric building units are expected to yield highly symmetric networks. In the case of octahedron and triangle combinations, MOFs based on pyrite (pyr) and rutile (rtl) nets were expected instead of qom. In this study, we have made 24 MOF-177 structures with different functional groups on the triangular BTB linker, having one or more functionalities. We find that the position of the functional groups on the BTB unit allows the selection for a specific net (qom, pyr, and rtl), and that mixing of functionalities (-H, -NH2, and -C4H4) is an important strategy for the incorporation of a specific functionality (-NO2) into MOF-177 where otherwise incorporation of such functionality would be difficult. Such mixing of functionalities to make multivariate MOF-177 structures leads to enhancement of hydrogen uptake by 25%.

Introduction of Functionality, Selection of Topology, and Enhancement of Gas Adsorption in Multivariate Metal–Organic Framework-177

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yue-Biao; Furukawa, Hiroyasu; Ko, Nakeun

2015-02-25

Metal–organic framework-177 (MOF-177) is one of the most porous materials whose structure is composed of octahedral Zn 4O(-COO) 6 and triangular 1,3,5-benzenetribenzoate (BTB) units to make a three-dimensional extended network based on the qom topology. This topology violates a long-standing thesis where highly symmetric building units are expected to yield highly symmetric networks. In the case of octahedron and triangle combinations, MOFs based on pyrite (pyr) and rutile (rtl) nets were expected instead of qom. In this study, we have made 24 MOF-177 structures with different functional groups on the triangular BTB linker, having one or more functionalities. We findmore » that the position of the functional groups on the BTB unit allows the selection for a specific net (qom, pyr, and rtl), and that mixing of functionalities (-H, -NH 2, and -C 4H 4) is an important strategy for the incorporation of a specific functionality (-NO 2) into MOF-177 where otherwise incorporation of such functionality would be difficult. Such mixing of functionalities to make multivariate MOF-177 structures leads to enhancement of hydrogen uptake by 25%.« less

Effect of air temperature and humidity on ingestive behaviour of sheep

NASA Astrophysics Data System (ADS)

Paranhos da Costa, Mateus J. R.; da Silva, Roberto Gomes; de Souza, Roberto Carlos

1992-12-01

Thirty-two Polwarth ewes, of ages up to 1 year, were observed in a climatic chamber (24 to 45° C) for eight periods of 5 h each. The observations were made through a window in the chamber wall. All animals were observed four times, then shorn and observed four times again. The animals were given weighed quantities of water and feed consisting of commercial concentrate plus Rhodes grass ( Chloris gayana) hay. The water and feed remaining after 5 h of observation were weighed. The following traits were analysed: time eating hay (TEH), time eating concentrate (TEC), time drinking water (TDW), weight of hay eaten (WHE), weight of concentrate eaten (WCE), volume of ingested water (VIW), ruminating time standing up (RTS), ruminating time lying down (RTL), idling time standing up (ITS), and idling time lying down (ITL). Shearing had a significant effect for all traits except ITS. Shearing resulted in higher values for all traits except for ITS and ITL. Ingestion of hay (TEH and WHE) decreased with increased air temperature and humidity, while the ingestion of concentrate (TEC) and WHE) and water (TDW and VIW) increased. Rumination decreased with increased air temperature and humidity, and was higher in shorn than in unshorn sheep.

High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women

PubMed Central

Okereke, Olivia I.; Prescott, Jennifer; Wong, Jason Y. Y.; Han, Jiali; Rexrode, Kathryn M.; De Vivo, Immaculata

2012-01-01

Background Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety – phobic anxiety – is related to telomere length. Methodology/Principal Findings Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured by quantitative real-time polymerase chain reaction among 5,243 women (aged 42–69 years) who: were participants in the Nurses' Health Study; were controls in prior case-control studies of telomeres and disease, or randomly selected healthy participants in a cognitive function sub-study; had completed the Crown-Crisp phobic index proximal to blood collection. Adjusted least-squares mean RTLs (z-scores) were calculated across phobic categories. Higher phobic anxiety was generally associated with lower RTLs (age-adjusted p-trend = 0.09); this association was similar after adjustment for confounders – paternal age-at-birth, smoking, body mass index (BMI) and physical activity (p-trend = 0.15). Notably, a threshold was identified. Among women with Crown-Crisp<6 points, the multivariable-adjusted least-squares mean RTL z-score = 0.02 standard units; however, among the most phobic women (Crown-Crisp≥6), the multivariable-adjusted least-squares mean RTL z-score = −0.09 standard units (mean difference = −0.10 standard units; p = 0.02). The magnitude of this difference was comparable to that for women 6 years apart in age. Finally, effect modification by BMI, smoking and paternal age was observed: associations were stronger among highly phobic women with BMI≥25 kg/m2, without smoking history, or born to fathers aged ≥40 years. Conclusions/Significance In this large, cross-sectional study high phobic anxiety was associated with shorter telomeres. These results point toward prospective investigations relating anxiety to telomere length change. PMID:22808180

Hardware accelerator of convolution with exponential function for image processing applications

NASA Astrophysics Data System (ADS)

Panchenko, Ivan; Bucha, Victor

2015-12-01

In this paper we describe a Hardware Accelerator (HWA) for fast recursive approximation of separable convolution with exponential function. This filter can be used in many Image Processing (IP) applications, e.g. depth-dependent image blur, image enhancement and disparity estimation. We have adopted this filter RTL implementation to provide maximum throughput in constrains of required memory bandwidth and hardware resources to provide a power-efficient VLSI implementation.

Russia’s Approach to Cyber Warfare (1Rev)

DTIC Science & Technology

2017-03-01

Steinitz, CNA. Approved by: March 2017 Ken E. Gause, RTL International Affairs Group Center for Strategic Studies REPORT DOCUMENTATION PAGE...the help of information networks.”7 Russian military thinkers on information operations IO and asymmetric military tactics, Col. S.G. Chekinov (Res...adversaries, influence public opinion, and reduce an opponent’s will to resist.8 Cyber IO affords the Russian government covert means to achieve these

Experiences of Parents with the Reading to Learn Approach: A Randomised Control Trial Initiative to Improve Literacy and Numeracy in Kenya and Uganda

ERIC Educational Resources Information Center

Abuya, Benta A.; Oketch, Moses; Ngware, Moses W.; Mutisya, Maurice; Musyoka, Peter K.

2015-01-01

Parental involvement in their children's schooling is in recognition that establishing the context in which a child attends school is important. Reading to Learn (RtL)was implemented in two districts of Kwale and Kinango in Kenya and of Amolatar and Dokolo in Uganda. This paper looks at parental involvement and their experiences with RtL. Data are…

Premature return to play and return to learn after a sport-related concussion: physician's chart review.

PubMed

Carson, James D; Lawrence, David W; Kraft, Sari A; Garel, Alisha; Snow, Catherine L; Chatterjee, Ananda; Libfeld, Paula; MacKenzie, Heather M; Thornton, Jane S; Moineddin, Rahim; Frémont, Pierre

2014-06-01

To determine what proportion of patients experience an exacerbation of their symptoms as a result of premature return to play (RTP) and return to learn (RTL) following sport-related concussions. Retrospective study of electronic medical records from the office-based practice of one family and sport medicine physician who had systematically provided recommendations for cognitive and physical rest based on existing consensus recommendations. Two blinded authors independently reviewed each chart, which included Sport Concussion Assessment Tool (SCAT) and SCAT2 symptom self-report forms to determine whether an athlete had returned to play or learn prematurely. If there was a discrepancy between the 2 reviewers then a third author reviewed the charts. A sport medicine and family practice in Ontario. The physician assessed sport-related concussions after self-referral or referral from other primary care physicians, teams, and schools. A total of 170 charts of 159 patients were assessed for sport-related concussion during a 5-year period (April 2006 to March 2011). All participants were students who were participating in sports at the time of injury. There were 41 concussions in elementary students, 95 concussions in high school students, and 34 concussions in college or university students. Premature RTP and RTL were defined as chart records documenting the recurrence or worsening of symptoms that accompanied the patients' RTP or RTL. Measures were compared using the earliest available SCAT forms and self-reporting. In 43.5% of concussion cases, the patient returned to sport too soon and in 44.7% of concussion cases, the patient returned to school too soon. Patients with a history of previous concussion required more days of rest before being permitted to participate in any physical activity than those patients without a previous history of concussion. Elementary school students required fewer days of rest before being permitted to return to any physical activity compared with high school students and college or university students. Currently, physicians recommend restrictions on mental and physical activity following sport-related concussion. This is done without clear guidelines as to what cognitive rest entails for students. Further research is required to determine how to implement a management plan for student athletes to facilitate complete recovery after concussion. Copyright© the College of Family Physicians of Canada.

Premature return to play and return to learn after a sport-related concussion

PubMed Central

Carson, James D.; Lawrence, David W.; Kraft, Sari A.; Garel, Alisha; Snow, Catherine L.; Chatterjee, Ananda; Libfeld, Paula; MacKenzie, Heather M.; Thornton, Jane S.; Moineddin, Rahim; Frémont, Pierre

2014-01-01

Abstract Objective To determine what proportion of patients experience an exacerbation of their symptoms as a result of premature return to play (RTP) and return to learn (RTL) following sport-related concussions. Design Retrospective study of electronic medical records from the office-based practice of one family and sport medicine physician who had systematically provided recommendations for cognitive and physical rest based on existing consensus recommendations. Two blinded authors independently reviewed each chart, which included Sport Concussion Assessment Tool (SCAT) and SCAT2 symptom self-report forms to determine whether an athlete had returned to play or learn prematurely. If there was a discrepancy between the 2 reviewers then a third author reviewed the charts. Setting A sport medicine and family practice in Ontario. The physician assessed sport-related concussions after self-referral or referral from other primary care physicians, teams, and schools. Participants A total of 170 charts of 159 patients were assessed for sport-related concussion during a 5-year period (April 2006 to March 2011). All participants were students who were participating in sports at the time of injury. There were 41 concussions in elementary students, 95 concussions in high school students, and 34 concussions in college or university students. Main outcome measures Premature RTP and RTL were defined as chart records documenting the recurrence or worsening of symptoms that accompanied the patients’ RTP or RTL. Measures were compared using the earliest available SCAT forms and self-reporting. Results In 43.5% of concussion cases, the patient returned to sport too soon and in 44.7% of concussion cases, the patient returned to school too soon. Patients with a history of previous concussion required more days of rest before being permitted to participate in any physical activity than those patients without a previous history of concussion. Elementary school students required fewer days of rest before being permitted to return to any physical activity compared with high school students and college or university students. Conclusion Currently, physicians recommend restrictions on mental and physical activity following sport-related concussion. This is done without clear guidelines as to what cognitive rest entails for students. Further research is required to determine how to implement a management plan for student athletes to facilitate complete recovery after concussion. PMID:24925965

Evaluation of automated sample preparation, retention time locked gas chromatography-mass spectrometry and data analysis methods for the metabolomic study of Arabidopsis species.

PubMed

Gu, Qun; David, Frank; Lynen, Frédéric; Rumpel, Klaus; Dugardeyn, Jasper; Van Der Straeten, Dominique; Xu, Guowang; Sandra, Pat

2011-05-27

In this paper, automated sample preparation, retention time locked gas chromatography-mass spectrometry (GC-MS) and data analysis methods for the metabolomics study were evaluated. A miniaturized and automated derivatisation method using sequential oximation and silylation was applied to a polar extract of 4 types (2 types×2 ages) of Arabidopsis thaliana, a popular model organism often used in plant sciences and genetics. Automation of the derivatisation process offers excellent repeatability, and the time between sample preparation and analysis was short and constant, reducing artifact formation. Retention time locked (RTL) gas chromatography-mass spectrometry was used, resulting in reproducible retention times and GC-MS profiles. Two approaches were used for data analysis. XCMS followed by principal component analysis (approach 1) and AMDIS deconvolution combined with a commercially available program (Mass Profiler Professional) followed by principal component analysis (approach 2) were compared. Several features that were up- or down-regulated in the different types were detected. Copyright © 2011 Elsevier B.V. All rights reserved.

Verification using Satisfiability Checking, Predicate Abstraction, and Craig Interpolation

DTIC Science & Technology

2008-09-01

297, 2007. 4.10.1 196 [48] Roberto Bruttomesso, Alessandro Cimatti, Anders Franzen, Alberto Grig- gio, Ziyad Hanna, Alexander Nadel, Amit Palti, and...using SAT based conflict analysis. In Formal Methods in Computer Aided Design, pages 33–51, 2002. 1.1, 7 [54] Alessandro Cimatti, Alberto Griggio, and...and D. Vroon. Automatic memory reductions for RTL-level verification. In ICCAD, 2006. 1.2.4, 6.2, 7 [108] Joao P. Marques-Silva and Karem A. Sakallah

Small range logarithm calculation on Intel Quartus II Verilog

NASA Astrophysics Data System (ADS)

Mustapha, Muhazam; Mokhtar, Anis Shahida; Ahmad, Azfar Asyrafie

2018-02-01

Logarithm function is the inverse of exponential function. This paper implement power series of natural logarithm function using Verilog HDL in Quartus II. The mode of design used is RTL in order to decrease the number of megafunctions. The simulations were done to determine the precision and number of LEs used so that the output calculated accurately. It is found that the accuracy of the system only valid for the range of 1 to e.

Prerequisites for sustainable care improvement using the reflective team as a work model.

PubMed

Jonasson, Lise-Lotte; Carlsson, Gunilla; Nyström, Maria

2014-01-01

Several work models for care improvement have been developed in order to meet the requirement for evidence-based care. This study examines a work model for reflection, entitled the reflective team (RT). The main idea behind RTs is that caring skills exist among those who work closest to the patients. The team leader (RTL) encourages sustainable care improvement, rooted in research and proven experience, by using a lifeworld perspective to stimulate further reflection and a developmental process leading to research-based caring actions within the team. In order to maintain focus, it is important that the RTL has a clear idea of what sustainable care improvement means, and what the prerequisites are for such improvement. The aim of the present study is, therefore, to explore the prerequisites for improving sustainable care, seeking to answer how RTLs perceive these and use RTs for concrete planning. Nine RTLs were interviewed, and their statements were phenomenographically analysed. The analysis revealed three separate qualitative categories, which describe personal, interpersonal, and structural aspects of the prerequisites. In the discussion, these categories are compared with previous research on reflection, and the conclusion is reached that the optimal conditions for RTs to work, when focussed on sustainable care improvement, occur when the various aspects of the prerequisites are intertwined and become a natural part of the reflective work.

Bullets with Names: The Deadly Dilemma

DTIC Science & Technology

1992-06-01

become dysfuctiona aoi requires reevahmir. w. iSTiuRtlNAVAEU MMMMr O A N5RL 21 ADSTMACrSnLSWC1O X uNCLAssiFIE~tm NumnrID j ] SAMEAs %’r. El uncuswa...Deter? ......................... 85 D. CONCL) J USIONS ......... ........................... 87 V. ASSASSINATION, REALPOLITIK" AND THE DEMOCRATIC IDEAL...Presideg s’ Serret Wars (New York: William Morrow and Company, Inc., 1986). 34-9. ’See George J . Church, ’ýGoing to the Source," Ijj 28 April 1986, 17

Strongly suppressed proximity effect and ferromagnetism in topological insulator/ferromagnet/superconductor thin film trilayers of Bi2Se3/SrRuO3/underdoped YBa2Cu3O x : a possible new platform for Majorana nano-electronics

NASA Astrophysics Data System (ADS)

Koren, Gad

2018-07-01

We report properties of a topological insulator–ferromagnet–superconductor trilayers comprised of thin films of 20 nm thick {Bi}}2{Se}}3 on 10 nm SrRuO3 on 30 nm {YBa}}2{Cu}}3{{{O}}}x. As deposited trilayers are underdoped and have a superconductive transition with {{T}}{{c}} onset at 75 K, zero resistance at 65 K, {{T}}Cueri} at 150 K and {{T}}* of about 200 K. Further reannealing under vacuum yields the 60 K phase of {YBa}}2{Cu}}3{{{O}}}x which still has zero resistance below about 40 K. Only when 10 × 100 microbridges were patterned in the trilayer, some of the bridges showed resistive behavior all the way down to low temperatures. Magnetoresistance versus temperature of the superconductive ones showed the typical peak due to flux flow against pinning below {{T}}{{c}}, while the resistive ones showed only the broad leading edge of such a peak. All this indicates clearly weak-link superconductivity in the resistive bridges between superconductive {YBa}}2{Cu}}3{{{O}}}x grains via the topological and ferromagnetic cap layers. Comparing our results to those of a reference trilayer (RTL) with the topological {Bi}}2{Se}}3 layer substituted by a non-superconducting highly overdoped {La}}1.65{Sr}}0.35{CuO}}4, indicates that the superconductive proximity effect as well as ferromagnetism in the topological trilayer are actually strongly suppressed compared to the non-topological RTL. This strong suppression could originate in lattice and Fermi levels mismatch as well as in short coherence length and unfavorable effects of strong spin–orbit coupling in {Bi}}2{Se}}3 on the d-wave pairing of {YBa}}2{Cu}}3{{{O}}}x. Proximity induced edge currents in the SRO/YBCO layer could lead to Majorana bound states, a possible signature of which is observed in the present study as zero bias conductance peaks.

OpenSoC Fabric

DOE Office of Scientific and Technical Information (OSTI.GOV)

2014-08-21

Recent advancements in technology scaling have shown a trend towards greater integration with large-scale chips containing thousands of processors connected to memories and other I/O devices using non-trivial network topologies. Software simulation proves insufficient to study the tradeoffs in such complex systems due to slow execution time, whereas hardware RTL development is too time-consuming. We present OpenSoC Fabric, an on-chip network generation infrastructure which aims to provide a parameterizable and powerful on-chip network generator for evaluating future high performance computing architectures based on SoC technology. OpenSoC Fabric leverages a new hardware DSL, Chisel, which contains powerful abstractions provided by itsmore » base language, Scala, and generates both software (C++) and hardware (Verilog) models from a single code base. The OpenSoC Fabric2 infrastructure is modeled after existing state-of-the-art simulators, offers large and powerful collections of configuration options, and follows object-oriented design and functional programming to make functionality extension as easy as possible.« less

Crystal Field Splittings of the Hund Ground States of Nd(N) Ions in S4 Symmetry: Theory and Application to the Ga(3+) Site of Gd3Sc2Ga3O12.

DTIC Science & Technology

1984-03-01

DRDAR-TSS-S (STINFO) ATTN DRXRES-RTL, TECH LIBRARY ABERDEN PROVING GROUND , MD 21005 NATICK, MA 01762 23 %.. * ,w...DRXSY-MP (LIBRARY) ABERDEEN PROVING GROUND , MD 21005 UNDER SECRETARY OF DEFENSE RES £ ENGINEERING COMMANDER ATTN TECHNICAL LIBRARY, 3C128 US ARMY MISSILE...SANDS MISSILE RANGE, N 88002 ABERDEEN PROVING GROUND , MD 21005 DIRECTOR COMMANDER 08 RMM BALLISTIC RESEARCH LABORATORY US ARMY TROOP SUPPORT COMMAND AT

Use and Design of an Active Data Dictionary for Local Validation of Input Data.

DTIC Science & Technology

1985-03-01

tl,--:selves ir tl~ce si tuations aire fro ~io-ntly lof~t to tlhcir ohfl Ipvices, an-. they aust 1.velo)p the ir own :r.tL i-,5 for v datinXL. inputs...progirams. Feijarltless off orijin, indocur.ite data aIre j’oi.;O.- in any -NTP ;-,,steni. Informa tion create.1 from inaccurite !Lta also tends to he...cLiect name, shcort name, syn%3nym or allases, source, narrative description, records/ filos that lise cr contain the lata object, data structure

A RFID specific participatory design approach to support design and implementation of real-time location systems in the operating room.

PubMed

Guédon, A C P; Wauben, L S G L; de Korne, D F; Overvelde, M; Dankelman, J; van den Dobbelsteen, J J

2015-01-01

Information technology, such as real-time location (RTL) systems using Radio Frequency IDentification (RFID) may contribute to overcome patient safety issues and high costs in healthcare. The aim of this work is to study if a RFID specific Participatory Design (PD) approach supports the design and the implementation of RTL systems in the Operating Room (OR). A RFID specific PD approach was used to design and implement two RFID based modules. The Device Module monitors the safety status of OR devices and the Patient Module tracks the patients' locations during their hospital stay. The PD principles 'multidisciplinary team', 'participation users (active involvement)' and 'early adopters' were used to include users from the RFID company, the university and the hospital. The design and implementation process consisted of two 'structured cycles' ('iterations'). The effectiveness of this approach was assessed by the acceptance in terms of level of use, continuity of the project and purchase. The Device Module included eight strategic and twelve tactical actions and the Patient Module included six strategic and twelve tactical actions. Both modules are now used on a daily basis and are purchased by the hospitals for continued use. The RFID specific PD approach was effective in guiding and supporting the design and implementation process of RFID technology in the OR. The multidisciplinary teams and their active participation provided insights in the social and the organizational context of the hospitals making it possible to better fit the technology to the hospitals' (future) needs.

The Effects of Commercial Airline Traffic on LSST Observing Efficiency

NASA Astrophysics Data System (ADS)

Gibson, Rose; Claver, Charles; Stubbs, Christopher

2016-01-01

The Large Synoptic Survey Telescope (LSST) is a ten-year survey that will map the southern sky in six different filters 800 times before the end of its run. In this paper, we explore the primary effect of airline traffic on scheduling the LSST observations in addition to the secondary effect of condensation trails, or contrails, created by the presence of the aircraft. The large national investment being made in LSST implies that small improvments observing efficiency through aircraft and contrail avoidance can result in a significant improvement in the quality of the survey and its science. We have used the Automatic Dependent Surveillance-Broadcast (ADS-B) signals received from commercial aircraft to monitor and record activity over the LSST site. We installed a ADS-B ground station on Cerro Pachón, Chile consiting of a1090Mhz antenna on the Andes Lidar Observatory feeding a RTL2832U software defined radio. We used dump1090 to convert the received ADS-B telementry into Basestation format, where we found that during the busiest time of the night there were only 4 signals being received each minute on average, which will have very small direct effect, if any, on the LSST observing scheduler. As part of future studies we will examin the effects of contrals on LSST observations. Gibson was supported by the NOAO/KPNO Research Experiences for Undergraduates (REU) Program which is funded by the National Science Foundation Research Experience for Undergraduates Program (AST-1262829).

Radioluminescence of polyester resin modified with acrylic acid and its salts

NASA Astrophysics Data System (ADS)

Szalińska, H.; Wypych, M.; Pietrzak, M.; Szadkowska-Nicze, M.

Polimal-109 polyester resin and its compounds containing acrylic acid and its salts such as: sodium, potassium, magnesium, calcium, barium, iron, cobalt, copper and manganese acrylates were studied by the radioluminescence method, including isothermal luminescence (ITL) at a radiation temperature of 77 K, thermoluminescence (RTL) and spectral distributions of isothermal luminescence. Measurements of optical absorption at 77 K before and after irradiation of the investigated samples were also carried out. The results obtained have shown that metal ions play a significant part in the processes taking place in the polyester matrix under the influence of γ 60Co radiation.

Development of technology for lightweight Beryllium Cassegrain Telescope for space applications and lessons learnt

NASA Astrophysics Data System (ADS)

Greger, R.; Rugi, E.; Hausner, Th.; Jahnen, W.; Frei, S.; Pellaton, D.; Mueller, P.; Hollenbach, I.

2017-11-01

This paper gives an overview on the development of a light weighted Cassegrain telescope with a 200 mm optical aperture as one key element of the Laser Altimeter which will fly on the BepiColombo mission to Mercury (BELA).The Receiver Telescope (RTL) collects the light pulse transmitted to Mercury and reflected from the planet's surface. Mercury's challenging thermal environment, the thermo-mechanical stability of the telescope and the stringent instrument's mass budget require the implementation of an innovative design solution to achieve the requested optical performance over an extended temperature range.

Effects of endocrine disruptors on imprinted gene expression in the mouse embryo

PubMed Central

Tran, Diana A; Rivas, Guillermo E; Singh, Purnima; Pfeifer, Gerd P

2011-01-01

Environmental endocrine disruptors (EDs) are synthetic chemicals that resemble natural hormones and are known to cause epigenetic perturbations. EDs have profound effects on development and fertility. Imprinted genes had been identified as candidate susceptibility loci to environmental insults because they are functionally haploid, and because the imprints undergo epigenetic resetting between generations. To screen for possible epigenetic perturbations caused by EDs at imprinted loci, we treated pregnant mice daily between 8.5 and 12.5 days post coitum (dpc) with di-(2-ethylhexyl)-phthalate (DEHP), bisphenol A (BPA), vinclozolin (VZ) or control oil vehicle. After isolating RNA from the placenta, yolk sac, amnion, head, body, heart, liver, lung, stomach and intestines of 13.5 dpc embryos we measured the allele-specific expression of 39 imprinted transcripts using multiplex single nucleotide primer extension (SNuPE) assays. In this representative data set we identified only a small number of transcripts that exhibited a substantial relaxation of imprinted expression with statistical significance: Slc22a18 with 10% relaxation in the embryo after BPA treatment; Rtl1as with 11 and 16% relaxation in the lung and placenta, respectively after BPA treatment; and Rtl1 with 12% relaxation in the yolk sac after DEHP treatment. Additionally, the standard deviation of allele-specificity increased in various organs after ED treatment for several transcripts including Igf2r, Rasgrf1, Usp29, Slc38a4 and Xist. Our data suggest that the maintenance of strongly biased monoallelic expression of imprinted genes is generally insensitive to EDs in the 13.5 dpc embryo and extra-embryonic organs, but is not immune to those effects. PMID:21636974

Retinal damage profiles and neuronal effects of laser treatment: comparison of a conventional photocoagulator and a novel 3-nanosecond pulse laser.

PubMed

Wood, John P M; Shibeeb, O'Sam; Plunkett, Malcolm; Casson, Robert J; Chidlow, Glyn

2013-03-28

To determine detailed effects to retinal cells and, in particular, neurons following laser photocoagulation using a conventional 532 nm Nd:YAG continuous wave (CW) laser. Furthermore, to determine whether a novel 3 ns pulse laser (retinal regeneration therapy; 2RT) could specifically ablate retinal pigment epithelium (RPE) cells without causing collateral damage to other retinal cells. Adult Dark Agouti (DA) rats were separated into four groups: control, CW laser (12.7 J/cm(2)/pulse, 100 ms pulse duration), or 3 ns pulse 2RT laser at one of two energy settings ("High," 2RT-H, 163 mJ/cm(2)/pulse; "Low," 2RT-L, 109 mJ/cm(2)/pulse). Animals were treated and killed after 6 hours to 7 days, and retina/RPE was analyzed by histologic assessment, Western blot, polymerase chain reaction, and immunohistochemistry. Both lasers caused focal loss of RPE cells with no destruction of Bruch's membrane; RPE cells were present at lesion sites again within 7 days of treatments. CW and 2RT-H treatments caused extensive and moderate damage, respectively, to the outer retina. There were no obvious effects to horizontal, amacrine, or ganglion cells, as defined by immunolabeling, but an activation of PKCα within bipolar cells was noted. There was little discernible damage to any cells other than the RPE with the 2RT-L treatment. Conventional laser photocoagulation caused death of RPE cells with associated widespread damage to the outer retina but little influence on the inner retina. The novel 3 ns 2RT laser, however, was able to selectively kill RPE cells without causing collateral damage to photoreceptors. Potential benefits of this laser for clinical treatment of diabetic macular edema are discussed.

Exposure to runoff from coal-tar-sealed pavement induces genotoxicity and impairment of DNA repair capacity in the RTL-W1 fish liver cell line

USGS Publications Warehouse

Kienzler, Aude; Mahler, Barbara J.; Van Metre, Peter C.; Schweigert, Nathalie; Devaux, Alain; Bony, Sylvie

2015-01-01

Coal-tar-based (CTB) sealcoat, frequently applied to parking lots and driveways in North America, contains elevated concentrations of polycyclic aromatic hydrocarbons (PAHs) and related compounds. The RTL-W1 fish liver cell line was used to investigate two endpoints (genotoxicity and DNA-repair-capacity impairment) associated with exposure to runoff from asphalt pavement with CTB sealcoat or with an asphalt-based sealcoat hypothesized to contain about 7% CTB sealcoat (AS-blend). Genotoxic potential was assessed by the Formamido pyrimidine glycosylase (Fpg)-modified comet assay for 1:10 and 1:100 dilutions of runoff samples collected from 5 h to 36 d following sealcoat application. DNA-repair capacity was assessed by the base excision repair comet assay for 1:10 dilution of samples collected 26 h and 36 d following application. Both assays were run with and without co-exposure to ultraviolet-A radiation (UVA). With co-exposure to UVA, genotoxic effects were significant for both dilutions of CTB runoff for three of four sample times, and for some samples of AS-blend runoff. Base excision repair was significantly impaired for CTB runoff both with and without UVA exposure, and for AS-blend runoff only in the absence of UVA. This study is the first to investigate the effects of exposure to the complex mixture of chemicals in coal tar on DNA repair capacity. The results indicate that co-exposure to runoff from CT-sealcoated pavement and UVA as much as a month after sealcoat application has the potential to cause genotoxicity and impair DNA repair capacity.

Exposure to runoff from coal-tar-sealed pavement induces genotoxicity and impairment of DNA repair capacity in the RTL-W1 fish liver cell line.

PubMed

Kienzler, Aude; Mahler, Barbara J; Van Metre, Peter C; Schweigert, Nathalie; Devaux, Alain; Bony, Sylvie

2015-07-01

Coal-tar-based (CTB) sealcoat, frequently applied to parking lots and driveways in North America, contains elevated concentrations of polycyclic aromatic hydrocarbons (PAHs) and related compounds. The RTL-W1 fish liver cell line was used to investigate two endpoints (genotoxicity and DNA-repair-capacity impairment) associated with exposure to runoff from asphalt pavement with CTB sealcoat or with an asphalt-based sealcoat hypothesized to contain about 7% CTB sealcoat (AS-blend). Genotoxic potential was assessed by the Formamido pyrimidine glycosylase (Fpg)-modified comet assay for 1:10 and 1:100 dilutions of runoff samples collected from 5 h to 36 d following sealcoat application. DNA-repair capacity was assessed by the base excision repair comet assay for 1:10 dilution of samples collected 26 h and 36 d following application. Both assays were run with and without co-exposure to ultraviolet-A radiation (UVA). With co-exposure to UVA, genotoxic effects were significant for both dilutions of CTB runoff for three of four sample times, and for some samples of AS-blend runoff. Base excision repair was significantly impaired for CTB runoff both with and without UVA exposure, and for AS-blend runoff only in the absence of UVA. This study is the first to investigate the effects of exposure to the complex mixture of chemicals in coal tar on DNA repair capacity. The results indicate that co-exposure to runoff from CT-sealcoated pavement and UVA as much as a month after sealcoat application has the potential to cause genotoxicity and impair DNA repair capacity. Copyright © 2015 Elsevier B.V. All rights reserved.

Equalizer tap length requirement for mode group delay-compensated fiber link with weakly random mode coupling.

PubMed

Bai, Neng; Li, Guifang

2014-02-24

The equalizer tap length requirement is investigated analytically and numerically for differential modal group delay (DMGD) compensated fiber link with weakly random mode coupling. Each span of the DMGD compensated link comprises multiple pairs of fibers which have opposite signs of DMGD. The result reveals that under weak random mode coupling, the required tap length of the equalizer is proportional to modal group delay of a single DMGD compensated pair, instead of the total modal group delay (MGD) of the entire link. By using small DMGD compensation step sizes, the required tap length (RTL) can be potentially reduced by 2 orders of magnitude.

Implementation of a Configurable Fault Tolerant Processor (CFTP)

DTIC Science & Technology

2003-03-01

internal structure ARCHITECTURE rtl OF log_barrel IS signal sel1, sel2, sel3, sel4 : std_logic_vector ( 1 downto 0); signal buf0b, buf0c...sel3(1) <= l_or_r and shift(2); sel3(0) <= ar_or_log and shift(2); sel4 (1) <= l_or_r and shift(3); sel4 (0) <= ar_or_log and shift(3); buf0b...out_word => buf3a ); mux4: word_mux4 port map ( a => buf3a, b => buf3b, c => buf3c, d => buf3d, sel => sel4

Triple Modular Redundancy (TMR) in a Configurable Fault-Tolerant Processor (CFTP) for Space Applications

DTIC Science & Technology

2003-12-01

internal structure ARCHITECTURE rtl OF log_barrel IS signal sel1, sel2, sel3, sel4 : std_logic_vector ( 1 downto 0); signal buf0b, buf0c, buf0d...shift(2); sel3(0) <= ar_or_log and shift(2); sel4 (1) <= l_or_r and shift(3); sel4 (0) <= ar_or_log and shift(3); buf0b <= in_word(14 downto 0...mux4: word_mux4 port map ( a => buf3a, b => buf3b, c => buf3c, d => buf3d, sel => sel4 , out_word => out_word

Evaluation of the FIR Example using Xilinx Vivado High-Level Synthesis Compiler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, Zheming; Finkel, Hal; Yoshii, Kazutomo

Compared to central processing units (CPUs) and graphics processing units (GPUs), field programmable gate arrays (FPGAs) have major advantages in reconfigurability and performance achieved per watt. This development flow has been augmented with high-level synthesis (HLS) flow that can convert programs written in a high-level programming language to Hardware Description Language (HDL). Using high-level programming languages such as C, C++, and OpenCL for FPGA-based development could allow software developers, who have little FPGA knowledge, to take advantage of the FPGA-based application acceleration. This improves developer productivity and makes the FPGA-based acceleration accessible to hardware and software developers. Xilinx Vivado HLSmore » compiler is a high-level synthesis tool that enables C, C++ and System C specification to be directly targeted into Xilinx FPGAs without the need to create RTL manually. The white paper [1] published recently by Xilinx uses a finite impulse response (FIR) example to demonstrate the variable-precision features in the Vivado HLS compiler and the resource and power benefits of converting floating point to fixed point for a design. To get a better understanding of variable-precision features in terms of resource usage and performance, this report presents the experimental results of evaluating the FIR example using Vivado HLS 2017.1 and a Kintex Ultrascale FPGA. In addition, we evaluated the half-precision floating-point data type against the double-precision and single-precision data type and present the detailed results.« less

Pyrosequencing for detection of lamivudine-resistant hepatitis B virus.

PubMed

Lindström, Anna; Odeberg, Jacob; Albert, Jan

2004-10-01

Chronic hepatitis B virus (HBV) infection can cause severe liver disease, including cirrhosis and hepatocellular carcinoma. Lamivudine is a relatively recent alternative to alpha interferon for the treatment of HBV infection, but unfortunately, resistance to lamivudine commonly develops during monotherapy. Lamivudine-resistant HBV mutants display specific mutations in the YMDD (tyrosine, methionine, aspartate, aspartate) motif of the viral polymerase (reverse transcriptase [rt]), which is the catalytic site of the enzyme, i.e., methionine 204 to isoleucine (rtM204I) or valine (rtM204V). The latter mutation is often accompanied by a compensatory leucine-to-methionine change at codon 180 (rtL180M). In the present study, a novel sequencing method, pyrosequencing, was applied to the detection of lamivudine resistance mutations and was compared with direct Sanger sequencing. The new pyrosequencing method had advantages in terms of throughput. Experiments with mixtures of wild-type and resistant viruses indicated that pyrosequencing can detect minor sequence variants in heterogeneous virus populations. The new pyrosequencing method was evaluated with a small number of patient samples, and the results showed that the method could be a useful tool for the detection of lamivudine resistance in the clinical setting.

A novel approach to transforming a non-targeted metabolic profiling method to a pseudo-targeted method using the retention time locking gas chromatography/mass spectrometry-selected ions monitoring.

PubMed

Li, Yong; Ruan, Qiang; Li, Yanli; Ye, Guozhu; Lu, Xin; Lin, Xiaohui; Xu, Guowang

2012-09-14

Non-targeted metabolic profiling is the most widely used method for metabolomics. In this paper, a novel approach was established to transform a non-targeted metabolic profiling method to a pseudo-targeted method using the retention time locking gas chromatography/mass spectrometry-selected ion monitoring (RTL-GC/MS-SIM). To achieve this transformation, an algorithm based on the automated mass spectral deconvolution and identification system (AMDIS), GC/MS raw data and a bi-Gaussian chromatographic peak model was developed. The established GC/MS-SIM method was compared with GC/MS-full scan (the total ion current and extracted ion current, TIC and EIC) methods, it was found that for a typical tobacco leaf extract, 93% components had their relative standard deviations (RSDs) of relative peak areas less than 20% by the SIM method, while 88% by the EIC method and 81% by the TIC method. 47.3% components had their linear correlation coefficient higher than 0.99, compared with 5.0% by the EIC and 6.2% by TIC methods. Multivariate analysis showed the pooled quality control samples clustered more tightly using the developed method than using GC/MS-full scan methods, indicating a better data quality. With the analysis of the variance of the tobacco samples from three different planting regions, 167 differential components (p<0.05) were screened out using the RTL-GC/MS-SIM method, but 151 and 131 by the EIC and TIC methods, respectively. The results show that the developed method not only has a higher sensitivity, better linearity and data quality, but also does not need complicated peak alignment among different samples. It is especially suitable for the screening of differential components in the metabolic profiling investigation. Copyright © 2012 Elsevier B.V. All rights reserved.

Systematic Review of Cognitive Function in Euthymic Bipolar Disorder and Pre-Surgical Temporal Lobe Epilepsy.

PubMed

Bostock, Emmanuelle C S; Kirkby, Kenneth C; Garry, Michael I; Taylor, Bruce V M

2017-01-01

Bipolar disorder (BD) and temporal lobe epilepsy (TLE) overlap in domains including epidemiology, treatment response, shared neurotransmitter involvement and temporal lobe pathology. Comparison of cognitive function in both disorders may indicate temporal lobe mediated processes relevant to BD. This systematic review examines neuropsychological test profiles in euthymic bipolar disorder type I (BD-I) and pre-surgical TLE and compares experimental designs used. A search of PubMed, PsychINFO, and Scopus using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted. Inclusion criteria were comparison group or pre- to post-surgical patients; reported neuropsychological tests; participants aged 18-60 years. Fifty six studies met criteria: 27 BD-I; 29 TLE. Deficits in BD-I compared to healthy controls (HC) were in executive function, attention span and verbal memory. Deficits in TLE compared to HC were in executive function and memory. In the pre- to post-surgical comparisons, verbal memory in left temporal lobe (LTL) and, less consistently, visuospatial memory in right temporal lobe (RTL) epilepsy declined following surgery. BD-I studies used comprehensive test batteries in well-defined euthymic patients compared to matched HC groups. TLE studies used convenience samples pre- to post-surgery, comparing LTL and RTL subgroups, few included comparisons to HC (5 studies). TLE studies typically examined a narrow range of known temporal lobe-mediated neuropsychological functions, particularly verbal and visuospatial memory. Both disorders exhibit deficits in executive function and verbal memory suggestive of both frontal and temporal lobe involvement. However, deficits in TLE are measured pre- to post-surgery and not controlled at baseline pre-surgery. Further research involving a head-to-head comparison of the two disorders on a broad range of neuropsychological tests is needed to clarify the nature and extent of cognitive deficits and potential overlaps.

Smoking in contemporary German television programming.

PubMed

Hanewinkel, Reiner; Wiborg, Gudrun

2007-01-01

To study the prevalence of smoking in German television in 2005. Content analysis of all programmes of the four main national channels Das Erste, ZDF RTL and Pro7 over one week between 3 pm and 12 pm. A total of 395 programmes were analysed (252 h of programming). Each programme was coded regarding whether there was one or more smoking occurrence, defined as active smoking or handling with tobacco products by a character. Smoking was portrayed in 176 (45%) of the programmes. Smoking occurrences were frequent in movies (77%), and in TV magazines (69%). Movies, films, and serials produced in Germany showed more often smoking (65%) compared with productions from abroad (48%; p = 0.051). Smoking is frequently portrayed in German TV.

Elastic Waves: Mental Models and Teaching/Learning Sequences

NASA Astrophysics Data System (ADS)

Tarantino, Giovanni

In last years many research studies have pointed out relevant student diff- culties in understanding the physics of mechanical waves. Moreover, it has been reported that these diffculties deal with some fundamental concepts as the role of the medium in wave propagation, the superposition principle and the mathematical description of waves involving the use of functions of two variables. In the context of pre-service courses for teacher preparation a teaching/learning (T/L) sequence based on using simple RTL experiments and interactive simulation environments aimed to show the effect of medium properties on the propagation speed of a wave pulse, has been experimented. Here, preliminary results of investigations carried out with a 120 traineeteacher (TT) group are reported and discussed.

In flight image processing on multi-rotor aircraft for autonomous landing

NASA Astrophysics Data System (ADS)

Henry, Richard, Jr.

An estimated $6.4 billion was spent during the year 2013 on developing drone technology around the world and is expected to double in the next decade. However, drone applications typically require strong pilot skills, safety, responsibilities and adherence to regulations during flight. If the flight control process could be safer and more reliable in terms of landing, it would be possible to further develop a wider range of applications. The objective of this research effort is to describe the design and evaluation of a fully autonomous Unmanned Aerial system (UAS), specifically a four rotor aircraft, commonly known as quad copter for precise landing applications. The full landing autonomy is achieved by image processing capabilities during flight for target recognition by employing the open source library OpenCV. In addition, all imaging data is processed by a single embedded computer that estimates a relative position with respect to the target landing pad. Results shows a reduction on the average offset error by 67.88% in comparison to the current return to lunch (RTL) method which only relies on GPS positioning. The present work validates the need for relying on image processing for precise landing applications instead of the inexact method of a commercial low cost GPS dependency.

IR-drop analysis for validating power grids and standard cell architectures in sub-10nm node designs

NASA Astrophysics Data System (ADS)

Ban, Yongchan; Wang, Chenchen; Zeng, Jia; Kye, Jongwook

2017-03-01

Since chip performance and power are highly dependent on the operating voltage, the robust power distribution network (PDN) is of utmost importance in designs to provide with the reliable voltage without voltage (IR)-drop. However, rapid increase of parasitic resistance and capacitance (RC) in interconnects makes IR-drop much worse with technology scaling. This paper shows various IR-drop analyses in sub 10nm designs. The major objectives are to validate standard cell architectures, where different sizes of power/ground and metal tracks are validated, and to validate PDN architecture, where types of power hook-up approaches are evaluated with IR-drop calculation. To estimate IR-drops in 10nm and below technologies, we first prepare physically routed designs given standard cell libraries, where we use open RISC RTL, synthesize the CPU, and apply placement & routing with process-design kits (PDK). Then, static and dynamic IR-drop flows are set up with commercial tools. Using the IR-drop flow, we compare standard cell architectures, and analysis impacts on performance, power, and area (PPA) with the previous technology-node designs. With this IR-drop flow, we can optimize the best PDN structure against IR-drops as well as types of standard cell library.

Real Time Linux - The RTOS for Astronomy?

NASA Astrophysics Data System (ADS)

Daly, P. N.

The BoF was attended by about 30 participants and a free CD of real time Linux-based upon RedHat 5.2-was available. There was a detailed presentation on the nature of real time Linux and the variants for hard real time: New Mexico Tech's RTL and DIAPM's RTAI. Comparison tables between standard Linux and real time Linux responses to time interval generation and interrupt response latency were presented (see elsewhere in these proceedings). The present recommendations are to use RTL for UP machines running the 2.0.x kernels and RTAI for SMP machines running the 2.2.x kernel. Support, both academically and commercially, is available. Some known limitations were presented and the solutions reported e.g., debugging and hardware support. The features of RTAI (scheduler, fifos, shared memory, semaphores, message queues and RPCs) were described. Typical performance statistics were presented: Pentium-based oneshot tasks running > 30kHz, 486-based oneshot tasks running at ~ 10 kHz, periodic timer tasks running in excess of 90 kHz with average zero jitter peaking to ~ 13 mus (UP) and ~ 30 mus (SMP). Some detail on kernel module programming, including coding examples, were presented showing a typical data acquisition system generating simulated (random) data writing to a shared memory buffer and a fifo buffer to communicate between real time Linux and user space. All coding examples were complete and tested under RTAI v0.6 and the 2.2.12 kernel. Finally, arguments were raised in support of real time Linux: it's open source, free under GPL, enables rapid prototyping, has good support and the ability to have a fully functioning workstation capable of co-existing hard real time performance. The counter weight-the negatives-of lack of platforms (x86 and PowerPC only at present), lack of board support, promiscuous root access and the danger of ignorance of real time programming issues were also discussed. See ftp://orion.tuc.noao.edu/pub/pnd/rtlbof.tgz for the StarOffice overheads for this presentation.

Digital interface of electronic transformers based on embedded system

NASA Astrophysics Data System (ADS)

Shang, Qiufeng; Qi, Yincheng

2008-10-01

Benefited from digital interface of electronic transformers, information sharing and system integration in substation can be realized. An embedded system-based digital output scheme of electronic transformers is proposed. The digital interface is designed with S3C44B0X 32bit RISC microprocessor as the hardware platform. The μCLinux operation system (OS) is transplanted on ARM7 (S3C44B0X). Applying Ethernet technology as the communication mode in the substation automation system is a new trend. The network interface chip RTL8019AS is adopted. Data transmission is realized through the in-line TCP/IP protocol of uClinux embedded OS. The application result and character analysis show that the design can meet the real-time and reliability requirements of IEC60044-7/8 electronic voltage/current instrument transformer standards.

Full cycle trigonometric function on Intel Quartus II Verilog

NASA Astrophysics Data System (ADS)

Mustapha, Muhazam; Zulkarnain, Nur Antasha

2018-02-01

This paper discusses about an improvement of a previous research on hardware based trigonometric calculations. Tangent function will also be implemented to get a complete set. The functions have been simulated using Quartus II where the result will be compared to the previous work. The number of bits has also been extended for each trigonometric function. The design is based on RTL due to its resource efficient nature. At earlier stage, a technology independent test bench simulation was conducted on ModelSim due to its convenience in capturing simulation data so that accuracy information can be obtained. On second stage, Intel/Altera Quartus II will be used to simulate on technology dependent platform, particularly on the one belonging to Intel/Altera itself. Real data on no. logic elements used and propagation delay have also been obtained.

Area and power efficient DCT architecture for image compression

NASA Astrophysics Data System (ADS)

Dhandapani, Vaithiyanathan; Ramachandran, Seshasayanan

2014-12-01

The discrete cosine transform (DCT) is one of the major components in image and video compression systems. The final output of these systems is interpreted by the human visual system (HVS), which is not perfect. The limited perception of human visualization allows the algorithm to be numerically approximate rather than exact. In this paper, we propose a new matrix for discrete cosine transform. The proposed 8 × 8 transformation matrix contains only zeros and ones which requires only adders, thus avoiding the need for multiplication and shift operations. The new class of transform requires only 12 additions, which highly reduces the computational complexity and achieves a performance in image compression that is comparable to that of the existing approximated DCT. Another important aspect of the proposed transform is that it provides an efficient area and power optimization while implementing in hardware. To ensure the versatility of the proposal and to further evaluate the performance and correctness of the structure in terms of speed, area, and power consumption, the model is implemented on Xilinx Virtex 7 field programmable gate array (FPGA) device and synthesized with Cadence® RTL Compiler® using UMC 90 nm standard cell library. The analysis obtained from the implementation indicates that the proposed structure is superior to the existing approximation techniques with a 30% reduction in power and 12% reduction in area.

An FPGA-based heterogeneous image fusion system design method

NASA Astrophysics Data System (ADS)

Song, Le; Lin, Yu-chi; Chen, Yan-hua; Zhao, Mei-rong

2011-08-01

Taking the advantages of FPGA's low cost and compact structure, an FPGA-based heterogeneous image fusion platform is established in this study. Altera's Cyclone IV series FPGA is adopted as the core processor of the platform, and the visible light CCD camera and infrared thermal imager are used as the image-capturing device in order to obtain dualchannel heterogeneous video images. Tailor-made image fusion algorithms such as gray-scale weighted averaging, maximum selection and minimum selection methods are analyzed and compared. VHDL language and the synchronous design method are utilized to perform a reliable RTL-level description. Altera's Quartus II 9.0 software is applied to simulate and implement the algorithm modules. The contrast experiments of various fusion algorithms show that, preferably image quality of the heterogeneous image fusion can be obtained on top of the proposed system. The applied range of the different fusion algorithms is also discussed.

Experimental demonstration of a real-time high-throughput digital DC blocker for compensating ADC imperfections in optical fast-OFDM receivers.

PubMed

Zhang, Lu; Ouyang, Xing; Shao, Xiaopeng; Zhao, Jian

2016-06-27

Performance degradation induced by the DC components at the output of real-time analogue-to-digital converter (ADC) is experimentally investigated for optical fast-OFDM receiver. To compensate this degradation, register transfer level (RTL) circuits for real-time digital DC blocker with 20GS/s throughput are proposed and implemented in field programmable gate array (FPGA). The performance of the proposed real-time digital DC blocker is experimentally investigated in a 15Gb/s optical fast-OFDM system with intensity modulation and direct detection over 40 km standard single-mode fibre. The results show that the fixed-point DC blocker has negligible performance penalty compared to the offline floating point one, and can overcome the error floor of the fast OFDM receiver caused by the DC components from the real-time ADC output.

Automating the AFROTC Four-Year Scholarship Program.

DTIC Science & Technology

1986-04-01

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Porting DubaiSat-2 Flight Software to RTEMS: A Feasibility Study

NASA Astrophysics Data System (ADS)

Khoory, Mohammed; Al Shamsi, Zakareyya; Al Midfa, Ibrahim

2015-09-01

This paper details the process taken by EIAST to study RTEMS as a potential real-time operating system for future space missions. The direction was to attempt to run the DubaiSat-2 flight software under RTEMS 4.10.2 with as little modification to the original source as possible. The implementation used a “translation layer” to translate system calls used by the DS-2 flight software into RTEMS system calls. The RTEMS RTL project was integrated to satisfy the run-time loading requirement, and some differences in the filesystem were encountered and worked around. The implementation was tested for performance and stability, and comparisons were made. The conclusion is that RTEMS provides an adequate base for future space missions with certain advantages over other RTOS’s including cost, a smaller executable size, and control over the source. Drawbacks include the slow speed of loading tasks during runtime and some filesystem integrity issues during unexpected reboots.

A VLSI Implementation of Four-Phase Lift Controller Using Verilog HDL

NASA Astrophysics Data System (ADS)

Kumar, Manish; Singh, Priyanka; Singh, Shesha

2017-08-01

With the advent of an era of staggering range of new technologies to provide ease of mobility and transportation elevators have become an essential component of all high rise buildings. An elevator is a type of vertical transportation that moves people between the floors of a high rise building. A four-Phase lift controller modeled on Verilog HDL code using Finite State Machine (FSM) has been presented in this paper. Verilog HDL helps in automated analysis and simulation of lift controller circuit. This design is based on synchronous input that operates on a fixed frequency. The Lift motion is controlled by means of accepting the destination floor level as input and generate control signal as output. In the proposed design a Verilog RTL code is developed and verified. Project Navigator of XILINX has been used as a code writing platform and results were simulated using Modelsim 5.4a simulator. This paper discusses the overall evolution of design and also discusses simulated results.

Ecotoxicological assessment of sediment, suspended matter and water samples in the upper Danube River. A pilot study in search for the causes for the decline of fish catches.

PubMed

Keiter, Steffen; Rastall, Andrew; Kosmehl, Thomas; Wurm, Karl; Erdinger, Lothar; Braunbeck, Thomas; Hollert, Henner

2006-09-01

Fish populations, especially those of the grayling (Thymallus thymallus), have declined over the last two decades in the upper Danube River between Sigmaringen and Ulm, despite intensive and continuous stocking and improvement of water quality since the 1970s. Similar problems have been reported for other rivers, e.g. in Switzerland, Great Britain, the United States and Canada. In order to assess if ecotoxicological effects might be related to the decline in fish catch at the upper Danube River, sediment, suspended matter and waste water samples from sewage treatment plants were collected at selected locations and analyzed in a bioanalytical approach using a battery of bioassays. The results of this pilot study will be used to decide if a comprehensive weight-of-evidence study is needed. Freeze-dried sediments and suspended particulate matters were extracted with acetone in a Soxhlet apparatus. Organic pollutants from sewage water were concentrated using XAD-resins. In order to investigate the ecotoxicological burden, the following bioassays were used: (1) neutral red assay with RTL-W1 cells (cytotoxicity), (2) comet assay with RTL-W1 cells (genotoxicity), (3) Arthrobacter globiformis dehydrogenase assay (toxicity to bacteria), (4) yeast estrogen screen assay (endocrine disruption), (5) fish egg assay with the zebrafish (Danio rerio; embryo toxicity) and (6) Ames test with TA98 (mutagenicity). The results of the in vitro tests elucidated a considerable genotoxic, cytotoxic, mutagenic, bacteriotoxic, embryotoxic and estrogenic burden in the upper Danube River, although with a very inhomogeneous distribution of effects. The samples taken from Riedlingen, for example, induced low embryo toxicity, but the second highest 17beta-estradiol equivalent concentration (1.8 ng/L). Using the fish egg assay with native sediments, a broad range of embryotoxic effects could be elucidated, with clear-cut dose-response relationships for the embryotoxic effects of contaminated sediments. With native sediments, embryotoxicity was clearly higher than with corresponding pore waters, thus corroborating the view that--at least for fish eggs--the bioavailability of particle-bound lipophilic substances in native sediments is higher than generally assumed. The effect observed most frequently in the fish egg assay was a developmental delay. A comparison of our own results with locations along the rivers Rhine and Neckar demonstrated similar or even higher ranges of ecotoxicological burdens in the Danube River. The complex pattern of ecotoxicological effects caused by environmental samples from the Danube River, when assessed in an in vitro biotest battery using both acute and more specific endpoints, showed that integration of different endpoints is essential for appropriate hazard assessment. Overall, the ecotoxicological hazard potential shown has indeed to be considered as one potential reason for the decline in fish catches at the upper Danube River. However, based on the results of this pilot study, it is not possible to elucidate that chemically induced alterations are responsible for the fish decline. In order to confirm the ecological relevance of the in vitro results for the situation in the field and especially for the decline of the grayling and other fishes, further integrated investigations are required. For linking the weight of evidence obtained by in vitro assays and fish population investigations, the application of additional, more specific biomarkers (e.g. vitellogenin induction, EROD and micronucleus assay) has been initiated in fish taken from the field as well as in situ investigations.

Silicon compilation: From the circuit to the system

NASA Astrophysics Data System (ADS)

Obrien, Keven

The methodology used for the compilation of silicon from a behavioral level to a system level is presented. The aim was to link the heretofore unrelated areas of high level synthesis and system level design. This link will play an important role in the development of future design automation tools as it will allow hardware/software co-designs to be synthesized. A design methodology that alllows, through the use of an intermediate representation, SOLAR, a System level Design Language (SDL), to be combined with a Hardware Description Language (VHDL) is presented. Two main steps are required in order to transform this specification into a synthesizable one. Firstly, a system level synthesis step including partitioning and communication synthesis is required in order to split the model into a set of interconnected subsystems, each of which will be processed by a high level synthesis tool. For this latter step AMICAL is used and this allows powerful scheduling techniques to be used, that accept very abstract descriptions of control flow dominated circuits as input, and interconnected RTL blocks that may feed existing logic-level synthesis tools to be generated.

Leadership and Stewardship of the Laboratory (Objective 4.1) Notable Outcome - Phase II Alternative Analysis and PNNL Site Plan Recommendation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pittman, Jeffery P.; Cassidy, Stephen R.; Mosey, Whitney LC

2013-07-31

Pacific Northwest National Laboratory (PNNL) and the Pacific Northwest Site Office (PNSO) have recently completed an effort to identify the current state of the campus and gaps that exist with regards to space needs, facilities and infrastructure. This effort has been used to establish a campus strategy to ensure PNNL is ready to further the United States (U.S.) Department of Energy (DOE) mission. Ten-year business projections and the impacts on space needs were assessed and incorporated into the long-term facility plans. In identifying/quantifying the space needs for PNNL, the following categories were addressed: Multi-purpose Programmatic (wet chemistry and imaging laboratorymore » space), Strategic (Systems Engineering and Computation Analytics, and Collaboration space), Remediation (space to offset the loss of the Research Technology Laboratory [RTL] Complex due to decontamination and demolition), and Optimization (the exit of older and less cost-effective facilities). The findings of the space assessment indicate a need for wet chemistry space, imaging space, and strategic space needs associated with systems engineering and collaboration space.« less

Disease dynamics and potential mitigation among restored and wild staghorn coral, Acropora cervicornis

PubMed Central

Lohr, Kathryn E.; Cameron, Caitlin M.; Williams, Dana E.; Peters, Esther C.

2014-01-01

The threatened status (both ecologically and legally) of Caribbean staghorn coral, Acropora cervicornis, has prompted rapidly expanding efforts in culture and restocking, although tissue loss diseases continue to affect populations. In this study, disease surveillance and histopathological characterization were used to compare disease dynamics and conditions in both restored and extant wild populations. Disease had devastating effects on both wild and restored populations, but dynamics were highly variable and appeared to be site-specific with no significant differences in disease prevalence between wild versus restored sites. A subset of 20 haphazardly selected colonies at each site observed over a four-month period revealed widely varying disease incidence, although not between restored and wild sites, and a case fatality rate of 8%. A tropical storm was the only discernable environmental trigger associated with a consistent spike in incidence across all sites. Lastly, two field mitigation techniques, (1) excision of apparently healthy branch tips from a diseased colony, and (2) placement of a band of epoxy fully enclosing the diseased margin, gave equivocal results with no significant benefit detected for either treatment compared to controls. Tissue condition of associated samples was fair to very poor; unsuccessful mitigation treatment samples had severe degeneration of mesenterial filament cnidoglandular bands. Polyp mucocytes in all samples were infected with suspect rickettsia-like organisms; however, no bacterial aggregates were found. No histological differences were found between disease lesions with gross signs fitting literature descriptions of white-band disease (WBD) and rapid tissue loss (RTL). Overall, our results do not support differing disease quality, quantity, dynamics, nor health management strategies between restored and wild colonies of A. cervicornis in the Florida Keys. PMID:25210660

Automating analog design: Taming the shrew

NASA Technical Reports Server (NTRS)

Barlow, A.

1990-01-01

The pace of progress in the design of integrated circuits continues to amaze observers inside and outside of the industry. Three decades ago, a 50 transistor chip was a technological wonder. Fifteen year later, a 5000 transistor device would 'wow' the crowds. Today, 50,000 transistor chips will earn a 'not too bad' assessment, but it takes 500,000 to really leave an impression. In 1975 a typical ASIC device had 1000 transistors, took one year to first samples (and two years to production) and sold for about 5 cents per transistor. Today's 50,000 transistor gate array takes about 4 months from spec to silicon, works the first time, and sells for about 0.02 cents per transistor. Fifteen years ago, the single most laborious and error prone step in IC design was the physical layout. Today, most IC's never see the hand of a layout designer: and automatic place and route tool converts the engineer's computer captured schematic to a complete physical design using a gate array or a library of standard cells also created by software rather than by designers. CAD has also been a generous benefactor to the digital design process. The architect of today's digital systems creates the design using an RTL or other high level simulator. Then the designer pushes a button to invoke the logic synthesizer-optimizer tool. A fault analyzer checks the result for testability and suggests where scan based cells will improve test coverage. One obstinate holdout amidst this parade of progress is the automation of analog design and its reduction to semi-custom techniques. This paper investigates the application of CAD techniques to analog design.

Dissection of the Human Multipotent Adult Progenitor Cell Secretome by Proteomic Analysis

PubMed Central

van't Hof, Wouter; Newell, Laura F.; Reddy, Ashok; Wilmarth, Phillip A.; David, Larry L.; Raber, Amy; Bogaerts, Annelies; Pinxteren, Jef; Deans, Robert J.; Maziarz, Richard T.

2013-01-01

Multipotent adult progenitor cells (MAPCs) are adult adherent stromal stem cells currently being assessed in acute graft versus host disease clinical trials with demonstrated immunomodulatory capabilities and the potential to ameliorate detrimental autoimmune and inflammation-related processes. Our previous studies documented that MAPCs secrete factors that play a role in regulating T-cell activity. Here we expand our studies using a proteomics approach to characterize and quantify MAPC secretome components secreted over 72 hours in vitro under steady-state conditions and in the presence of the inflammatory triggers interferon-γ and lipopolysaccharide, or a tolerogenic CD74 ligand, RTL1000. MAPCs differentially responded to each of the tested stimuli, secreting molecules that regulate the biological activity of the extracellular matrix (ECM), including proteins that make up the ECM itself, proteins that regulate its construction/deconstruction, and proteins that serve to attach and detach growth factors from ECM components for redistribution upon appropriate stimulation. MAPCs secreted a wide array of proteases, some detectable in their zymogen forms. MAPCs also secreted protease inhibitors that would regulate protease activity. MAPCs secreted chemokines and cytokines that could provide molecular guidance cues to various cell types, including neutrophils, macrophages, and T cells. In addition, MAPCs secreted factors involved in maintenance of a homeostatic environment, regulating such diverse programs as innate immunity, angiogenesis/angiostasis, targeted delivery of growth factors, and the matrix-metalloprotease cascade. PMID:23981727

STRS SpaceWire FPGA Module

NASA Technical Reports Server (NTRS)

Lux, James P.; Taylor, Gregory H.; Lang, Minh; Stern, Ryan A.

2011-01-01

An FPGA module leverages the previous work from Goddard Space Flight Center (GSFC) relating to NASA s Space Telecommunications Radio System (STRS) project. The STRS SpaceWire FPGA Module is written in the Verilog Register Transfer Level (RTL) language, and it encapsulates an unmodified GSFC core (which is written in VHDL). The module has the necessary inputs/outputs (I/Os) and parameters to integrate seamlessly with the SPARC I/O FPGA Interface module (also developed for the STRS operating environment, OE). Software running on the SPARC processor can access the configuration and status registers within the SpaceWire module. This allows software to control and monitor the SpaceWire functions, but it is also used to give software direct access to what is transmitted and received through the link. SpaceWire data characters can be sent/received through the software interface, as well as through the dedicated interface on the GSFC core. Similarly, SpaceWire time codes can be sent/received through the software interface or through a dedicated interface on the core. This innovation is designed for plug-and-play integration in the STRS OE. The SpaceWire module simplifies the interfaces to the GSFC core, and synchronizes all I/O to a single clock. An interrupt output (with optional masking) identifies time-sensitive events within the module. Test modes were added to allow internal loopback of the SpaceWire link and internal loopback of the client-side data interface.

Rapid identification of fatty acid methyl esters using a multidimensional gas chromatography-mass spectrometry database.

PubMed

Härtig, Claus

2008-01-04

A multidimensional approach for the identification of fatty acid methyl esters (FAME) based on GC/MS analysis is described. Mass spectra and retention data of more than 130 FAME from various sources (chain lengths in the range from 4 to 24 carbon atoms) were collected in a database. Hints for the interpretation of FAME mass spectra are given and relevant diagnostic marker ions are deduced indicating specific groups of fatty acids. To verify the identity of single species and to ensure an optimized chromatographic resolution, the database was compiled with retention data libraries acquired on columns of different polarity (HP-5, DB-23, and HP-88). For a combined use of mass spectra and retention data standardized methods of measurement for each of these columns are required. Such master methods were developed and always applied under the conditions of retention time locking (RTL) which allowed an excellent reproducibility and comparability of absolute retention times. Moreover, as a relative retention index system, equivalent chain lengths (ECL) of FAME were determined by linear interpolation. To compare and to predict ECL values by means of structural features, fractional chain lengths (FCL) were calculated and fitted as well. As shown in an example, the use of retention data and mass spectral information together in a database search leads to an improved and reliable identification of FAME (including positional and geometrical isomers) without further derivatizations.

Direct Digital Demultiplexing of Analog TDM Signals for Cable Reduction in Ultrasound Imaging Catheters

PubMed Central

Carpenter, Thomas M.; Rashid, M. Wasequr; Ghovanloo, Maysam; Cowell, David M. J.; Freear, Steven; Degertekin, F. Levent

2016-01-01

In real-time catheter based 3D ultrasound imaging applications, gathering data from the transducer arrays is difficult as there is a restriction on cable count due to the diameter of the catheter. Although area and power hungry multiplexing circuits integrated at the catheter tip are used in some applications, these are unsuitable for use in small sized catheters for applications like intracardiac imaging. Furthermore, the length requirement for catheters and limited power available to on-chip cable drivers leads to limited signal strength at the receiver end. In this paper an alternative approach using Analog Time Division Multiplexing (TDM) is presented which addresses the cable restrictions of ultrasound catheters. A novel digital demultiplexing technique is also described which allows for a reduction in the number of analog signal processing stages required. The TDM and digital demultiplexing schemes are demonstrated for an intracardiac imaging system that would operate in the 4 MHz to 11 MHz range. A TDM integrated circuit (IC) with 8:1 multiplexer is interfaced with a fast ADC through a micro-coaxial catheter cable bundle, and processed with an FPGA RTL simulation. Input signals to the TDM IC are recovered with −40 dB crosstalk between channels on the same micro-coax, showing the feasibility of this system for ultrasound imaging applications. PMID:27116738

Characterization of AFLAV, a Tf1/Sushi retrotransposon from Aspergillus flavus.

PubMed

Hua, Sui-Sheng T; Tarun, Alice S; Pandey, Sonal N; Chang, Leo; Chang, Perng-Kuang

2007-02-01

The plasmid, pAF28, a genomic clone from Aspergillus flavus NRRL 6541, has been used as a hybridization probe to fingerprint A. flavus strains isolated in corn and peanut fields. The insert of pAF28 contains a 4.5 kb region which encodes a truncated retrotransposon (AfRTL-1). In search for a full-length and intact copy of retrotransposon, we exploited a novel PCR cloning strategy by amplifying a 3.4 kb region from the genomic DNA of A. flavus NRRL 6541. The fragment was cloned into pCR 4-TOPO. Sequence analysis confirmed that this region encoded putative domains of partial reverse transcriptase, RNase H, and integrase of the predicted retrotransposon. The two flanking long terminal repeats (LTRs) and the sequence between them comprise a putative full-length LTR retrotransposon of 7799 bp in length. This intact retrotransposon sequence is named AFLAV (A. flavus Retrotransposon). The order of the predicted catalytic domains in the polyprotein (Pol) placed AFLAV in the Tf1/sushi subgroup of the Ty3/gypsy retrotransposon family. Primers derived from AFLAV sequence were used to screen this retrotransposon in other strains of A. flavus. More than fifty strains of A. flavus isolated from different geological origins were surveyed and the results show that many strains have extensive deletions in the regions encoding the capsid (Gag) and Pol.

Design and implementation of embedded un-interruptible power supply system (EUPSS) for web-based mobile application

NASA Astrophysics Data System (ADS)

Zhang, De-gan; Zhang, Xiao-dan

2012-11-01

With the growth of the amount of information manipulated by embedded application systems, which are embedded into devices and offer access to the devices on the internet, the requirements of saving the information systemically is necessary so as to fulfil access from the client and the local processing more efficiently. For supporting mobile applications, a design and implementation solution of embedded un-interruptible power supply (UPS) system (in brief, EUPSS) is brought forward for long-distance monitoring and controlling of UPS based on Web. The implementation of system is based on ATmega161, RTL8019AS and Arm chips with TCP/IP protocol suite for communication. In the embedded UPS system, an embedded file system is designed and implemented which saves the data and index information on a serial EEPROM chip in a structured way and communicates with a microcontroller unit through I2C bus. By embedding the file system into UPS system or other information appliances, users can access and manipulate local data on the web client side. Embedded file system on chips will play a major role in the growth of IP networking. Based on our experiment tests, the mobile users can easily monitor and control UPS in different places of long-distance. The performance of EUPSS has satisfied the requirements of all kinds of Web-based mobile applications.

Finding needles in haystacks: linking scientific names, reference specimens and molecular data for Fungi.

PubMed

Schoch, Conrad L; Robbertse, Barbara; Robert, Vincent; Vu, Duong; Cardinali, Gianluigi; Irinyi, Laszlo; Meyer, Wieland; Nilsson, R Henrik; Hughes, Karen; Miller, Andrew N; Kirk, Paul M; Abarenkov, Kessy; Aime, M Catherine; Ariyawansa, Hiran A; Bidartondo, Martin; Boekhout, Teun; Buyck, Bart; Cai, Qing; Chen, Jie; Crespo, Ana; Crous, Pedro W; Damm, Ulrike; De Beer, Z Wilhelm; Dentinger, Bryn T M; Divakar, Pradeep K; Dueñas, Margarita; Feau, Nicolas; Fliegerova, Katerina; García, Miguel A; Ge, Zai-Wei; Griffith, Gareth W; Groenewald, Johannes Z; Groenewald, Marizeth; Grube, Martin; Gryzenhout, Marieka; Gueidan, Cécile; Guo, Liangdong; Hambleton, Sarah; Hamelin, Richard; Hansen, Karen; Hofstetter, Valérie; Hong, Seung-Beom; Houbraken, Jos; Hyde, Kevin D; Inderbitzin, Patrik; Johnston, Peter R; Karunarathna, Samantha C; Kõljalg, Urmas; Kovács, Gábor M; Kraichak, Ekaphan; Krizsan, Krisztina; Kurtzman, Cletus P; Larsson, Karl-Henrik; Leavitt, Steven; Letcher, Peter M; Liimatainen, Kare; Liu, Jian-Kui; Lodge, D Jean; Luangsa-ard, Janet Jennifer; Lumbsch, H Thorsten; Maharachchikumbura, Sajeewa S N; Manamgoda, Dimuthu; Martín, María P; Minnis, Andrew M; Moncalvo, Jean-Marc; Mulè, Giuseppina; Nakasone, Karen K; Niskanen, Tuula; Olariaga, Ibai; Papp, Tamás; Petkovits, Tamás; Pino-Bodas, Raquel; Powell, Martha J; Raja, Huzefa A; Redecker, Dirk; Sarmiento-Ramirez, J M; Seifert, Keith A; Shrestha, Bhushan; Stenroos, Soili; Stielow, Benjamin; Suh, Sung-Oui; Tanaka, Kazuaki; Tedersoo, Leho; Telleria, M Teresa; Udayanga, Dhanushka; Untereiner, Wendy A; Diéguez Uribeondo, Javier; Subbarao, Krishna V; Vágvölgyi, Csaba; Visagie, Cobus; Voigt, Kerstin; Walker, Donald M; Weir, Bevan S; Weiß, Michael; Wijayawardene, Nalin N; Wingfield, Michael J; Xu, J P; Yang, Zhu L; Zhang, Ning; Zhuang, Wen-Ying; Federhen, Scott

2014-01-01

DNA phylogenetic comparisons have shown that morphology-based species recognition often underestimates fungal diversity. Therefore, the need for accurate DNA sequence data, tied to both correct taxonomic names and clearly annotated specimen data, has never been greater. Furthermore, the growing number of molecular ecology and microbiome projects using high-throughput sequencing require fast and effective methods for en masse species assignments. In this article, we focus on selecting and re-annotating a set of marker reference sequences that represent each currently accepted order of Fungi. The particular focus is on sequences from the internal transcribed spacer region in the nuclear ribosomal cistron, derived from type specimens and/or ex-type cultures. Re-annotated and verified sequences were deposited in a curated public database at the National Center for Biotechnology Information (NCBI), namely the RefSeq Targeted Loci (RTL) database, and will be visible during routine sequence similarity searches with NR_prefixed accession numbers. A set of standards and protocols is proposed to improve the data quality of new sequences, and we suggest how type and other reference sequences can be used to improve identification of Fungi. Database URL: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA177353. Published by Oxford University Press 2013. This work is written by US Government employees and is in the public domain in the US.

From Zn(II)-Carboxylate to Double-Walled Zn(II)-Carboxylato Phosphate MOF: Change in the Framework Topology, Capture and Conversion of CO2, and Catalysis of Strecker Reaction.

PubMed

Gupta, Mayank; De, Dinesh; Tomar, Kapil; Bharadwaj, Parimal K

2017-12-04

The ligand H 2 L has been built by linking an imidazole moiety to the 5-position of isophthalic acid. It forms two types of porous frameworks, {[Zn(L)]·2DMF·2H 2 O} n (1) and {[(CH 3 ) 2 NH 2 ][Zn 2 (L)(H 2 O)PO 4 ]·2DMF} n (2). 1 is a porous neutral framework and has rtl rutile 3,6-conn topology, while 2 is an organo-metallophosphate anionic porous framework with double-walled hexagonal channels. Framework 1' (desolvated) exhibits moderate CO 2 adsorption (58 cc g -1 at 273 K, 1 bar), whereas 2' (desolvated) shows a microporous nature with a high adsorption of CO 2 (111.7 cc g -1 or 22 wt % at 273 K, 1 bar). Interestingly, this adsorbed CO 2 could be converted very efficiently to cyclic carbonates under mild conditions using 2' as the catalyst in the presence of tetrabutylammonium bromide as the cocatalyst. The presence of open metal sites in 2' makes it an efficient heterogeneous catalyst for solvent-free three-component Strecker reaction using various aldehydes/ketones together with amines and trimethylsilyl cyanide in high yields at room temperature. The straightforward experimental and product isolation procedure along with easy recovery and reusability of the catalyst provided an attractive route for the synthesis of α-amino nitriles.

Hepatitis B Virus Genotype Distribution and Its Lamivudine-Resistant Mutants in HIV-Coinfected Patients with Chronic and Occult Hepatitis B

PubMed Central

Quarleri, J.; Moretti, F.; Bouzas, M.B.; Laufer, N.; Carrillo, M. Gómez; Giuliano, S. Fernández; Pérez, H.; Cahn, P.; Salomon, H.

2010-01-01

Hepatitis B virus (HBV) genotypes were examined in HIV-infected patients with chronic and occult HBV infection. From a total population of 593 HIV-infected patients, 22 individuals (prevalence 3.7%) were found to be HBsAg while 72 (12.1%) were found to be anti-HBc alone. From them, 20 and 4 were HBV DNA positive, respectively. These last four patients are therefore considered to be HBV infected in an occult form. The genotypes could be determined in all 24 HBV-infected patients. HBV-A was the most common (20/24; 83.3%), followed by HBV-D (2/24; 8.3%) and HBV-F (1/24; 4.2%). The remaining sample exhibited mixed infection involving genotypes A and D as pure ones, thus also forming part of three intergenotypic recombinant forms exhibiting different mosaic S gene patterns. The sexual route of transmission was predominant among HBV genotype A-infected patients. Among the 24 HBV DNA-positive patients, point mutations related to lamivudine resistance were found in four strains. These viral strains showed a methionine-to-valine substitution at codon 204 (rtM204V) in association with an upstream B-domain change at rtL180M. Additionally, two of them exhibited the additional rtV173L mutation. The value of HBV molecular monitoring including both HBV viral genomic characterization and genotypic resistance profile in HIV-HBV-coinfected individuals is discussed. PMID:17506609

Reading words and other people: A comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia.

PubMed

Binney, Richard J; Henry, Maya L; Babiak, Miranda; Pressman, Peter S; Santos-Santos, Miguel A; Narvid, Jared; Mandelli, Maria Luisa; Strain, Paul J; Miller, Bruce L; Rankin, Katherine P; Rosen, Howard J; Gorno-Tempini, Maria Luisa

2016-09-01

Semantic variant primary progressive aphasia (svPPA) typically presents with left-hemisphere predominant rostral temporal lobe (rTL) atrophy and the most significant complaints within the language domain. Less frequently, patients present with right-hemisphere predominant temporal atrophy coupled with marked impairments in processing of famous faces and emotions. Few studies have objectively compared these patient groups in both domains and therefore it is unclear to what extent the syndromes overlap. Clinically diagnosed svPPA patients were characterized as left- (n = 21) or right-predominant (n = 12) using imaging and compared along with 14 healthy controls. Regarding language, our primary focus was upon two hallmark features of svPPA; confrontation naming and surface dyslexia. Both groups exhibited naming deficits and surface dyslexia although the impairments were more severe in the left-predominant group. Familiarity judgments on famous faces and affect processing were more profoundly impaired in the right-predominant group. Our findings suggest that the two syndromes overlap significantly but that early cases at the tail ends of the continuum constitute a challenge for current clinical criteria. Correlational neuroimaging analyses implicated a mid portion of the left lateral temporal lobe in exception word reading impairments in line with proposals that this region is an interface between phonology and semantic knowledge. Copyright © 2016 Elsevier Ltd. All rights reserved.

NASA/BAE SYSTEMS SpaceWire Effort

NASA Technical Reports Server (NTRS)

Rakow, Glenn Parker; Schnurr, Richard G.; Kapcio, Paul

2003-01-01

This paper discusses the state of the NASA and BAE SYSTEMS developments of SpaceWire. NASA has developed intellectual property that implements SpaceWire in Register Transfer Level (RTL) VHDL for a SpaceWire link and router. This design has been extensively verified using directed tests from the SpaceWire Standard and design specification, as well as being randomly tested to flush out hard to find bugs in the code. The high level features of the design will be discussed, including the support for multiple time code masters, which will be useful for the James Webb Space Telescope electrical architecture. This design is now ready to be targeted to FPGA's and ASICs. Target utilization and performance information will be presented for Spaceflight worthy FPGA's and a discussion of the ASIC implementations will be addressed. In particular, the BAE SYSTEMS ASIC will be highlighted which will be implemented on their .25micron rad-hard line. The chip will implement a 4-port router with the ability to tie chips together to make larger routers without external glue logic. This part will have integrated LVDS drivers/receivers, include a PLL and include skew control logic. It will be targeted to run at greater than 300 MHz and include the implementation for the proposed SpaceWire transport layer. The need to provide a reliable transport mechanism for SpaceWire has been identified by both NASA And ESA, who are attempting to define a transport layer standard that utilizes a low overhead, low latency connection oriented approach that works end-to-end. This layer needs to be implemented in hardware to prevent bottlenecks.

Information Content in Radio Waves: Student Investigations in Radio Science

NASA Astrophysics Data System (ADS)

Jacobs, K.; Scaduto, T.

2013-12-01

We describe an inquiry-based instructional unit on information content in radio waves, created in the summer of 2013 as part of a MIT Haystack Observatory (Westford, MA) NSF Research Experiences for Teachers (RET) program. This topic is current and highly relevant, addressing science and technical aspects from radio astronomy, geodesy, and atmospheric research areas as well as Next Generation Science Standards (NGSS). Projects and activities range from simple classroom demonstrations and group investigations, to long term research projects incorporating data acquisition from both student-built instrumentation as well as online databases. Each of the core lessons is applied to one of the primary research centers at Haystack through an inquiry project that builds on previously developed units through the MIT Haystack RET program. In radio astronomy, students investigate the application of a simple and inexpensive software defined radio chip (RTL-SDR) for use in systems implementing a small and very small radio telescope (SRT and VSRT). Both of these systems allow students to explore fundamental principles of radio waves and interferometry as applied to radio astronomy. In ionospheric research, students track solar storms from the initial coronal mass ejection (using Solar Dynamics Observatory images) to the resulting variability in total electron density concentrations using data from the community standard Madrigal distributed database system maintained by MIT Haystack. Finally, students get to explore very long-baseline interferometry as it is used in geodetic studies by measuring crustal plate displacements over time. Alignment to NextGen standards is provided for each lesson and activity with emphasis on HS-PS4 'Waves and Their Applications in Technologies for Information Transfer'.

Sound Frequency Representation in the Auditory Cortex of the Common Marmoset Visualized Using Optical Intrinsic Signal Imaging

PubMed Central

Tani, Toshiki; Abe, Hiroshi; Hayami, Taku; Banno, Taku; Kitamura, Naohito; Mashiko, Hiromi

2018-01-01

Abstract Natural sound is composed of various frequencies. Although the core region of the primate auditory cortex has functionally defined sound frequency preference maps, how the map is organized in the auditory areas of the belt and parabelt regions is not well known. In this study, we investigated the functional organizations of the core, belt, and parabelt regions encompassed by the lateral sulcus and the superior temporal sulcus in the common marmoset (Callithrix jacchus). Using optical intrinsic signal imaging, we obtained evoked responses to band-pass noise stimuli in a range of sound frequencies (0.5–16 kHz) in anesthetized adult animals and visualized the preferred sound frequency map on the cortical surface. We characterized the functionally defined organization using histologically defined brain areas in the same animals. We found tonotopic representation of a set of sound frequencies (low to high) within the primary (A1), rostral (R), and rostrotemporal (RT) areas of the core region. In the belt region, the tonotopic representation existed only in the mediolateral (ML) area. This representation was symmetric with that found in A1 along the border between areas A1 and ML. The functional structure was not very clear in the anterolateral (AL) area. Low frequencies were mainly preferred in the rostrotemplatal (RTL) area, while high frequencies were preferred in the caudolateral (CL) area. There was a portion of the parabelt region that strongly responded to higher sound frequencies (>5.8 kHz) along the border between the rostral parabelt (RPB) and caudal parabelt (CPB) regions. PMID:29736410

Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss).

PubMed

Fischer, Stephan; Loncar, Jovica; Zaja, Roko; Schnell, Sabine; Schirmer, Kristin; Smital, Tvrtko; Luckenbach, Till

2011-01-25

Permanent fish cell lines have become common model systems for determining ecotoxicological effects of pollutants. For these cell lines little is known on the cellular active transport mechanisms that control the amount of a compound entering the cell, such as the MXR (multixenobiotic resistance) system mediated by ATP binding cassette (ABC) transport proteins. Therefore, for toxic evaluation of chemicals with those cells information on MXR is important. We here present data on constitutive mRNA expression and protein activity levels of a series of ABC efflux transporters in seven permanent cell lines derived from liver (RTL-W1; R1) and liver hepatoma (RTH-149), gill (RTgill-W1), gonad (RTG-2), gut (RTgutGC) and brain (RTbrain) of rainbow trout (Oncorhynchus mykiss). In addition to known transporters abcb1 (designated here abcb1a), abcb11, abcc1-3, abcc5 and abcg2, we quantified expression levels of a newly identified abcb1 isoform (abcb1b) and abcc4, previously unknown in trout. Quantitative real time PCR (qPCR) indicated that mRNA of the examined ABC transporters was constitutively expressed in all cell lines. Transporter mRNA expression patterns were similar in all cell lines, with expression levels of abcc transporters being 80 to over 1000 fold higher than for abcg2, abcb1a/b and abcb11 (abcc1-5>abcg2>abcb1a/b, 11). Transporter activity in the cell lines was determined by measuring uptake of transporter type specific fluorescent substrates in the presence of activity inhibitors. The combination of the ABCB1 and ABCC transporter substrate calcein-AM with inhibitors cyclosporine A, PSC833 and MK571 resulted in a concentration-dependent fluorescence increase of up to 3-fold, whereas reversin 205 caused a slight, but not concentration-dependent fluorescence increase. Accumulation of the dyes Hoechst 33342 and 2',7'-dichlorodihydrofluorescein diacetate was basically unchanged in the presence of Ko134 and taurocholate, respectively, indicating low Abcg2 and Abcb11 activities, in accordance with low abcg2 and abcb11 transcript levels. Our data indicate that transporter expression and activity patterns in the different trout cell lines are irrespective of the tissue of origin, but are determined by factors of cell cultivation. 2010 Elsevier B.V. All rights reserved.

Reliable Transport over SpaceWire for James Webb Space Telescope (JWST) Focal Plane Electronics (FPE) Network

NASA Technical Reports Server (NTRS)

Rakow, Glenn; Schnurr, Richard; Dailey, Christopher; Shakoorzadeh, Kamdin

2003-01-01

NASA's James Webb Space Telescope (JWST) faces difficult technical and budgetary challenges to overcome before it is scheduled launch in 2010. The Integrated Science Instrument Module (ISIM), shares these challenges. The major challenge addressed in this paper is the data network used to collect, process, compresses and store Infrared data. A total of 114 Mbps of raw information must be collected from 19 sources and delivered to the two redundant data processing units across a twenty meter deployed thermally restricted interface. Further data must be transferred to the solid-state recorder and the spacecraft. The JWST detectors are kept at cryogenic temperatures to obtain the sensitivity necessary to measure faint energy sources. The Focal Plane Electronics (FPE) that sample the detector, generate packets from the samples, and transmit these packets to the processing electronics must dissipate little power in order to help keep the detectors at these cold temperatures. Separating the low powered front-end electronics from the higher-powered processing electronics, and using a simple high-speed protocol to transmit the detector data minimize the power dissipation near the detectors. Low Voltage Differential Signaling (LVDS) drivers were considered an obvious choice for physical layer because of their high speed and low power. The mechanical restriction on the number cables across the thermal interface force the Image packets to be concentrated upon two high-speed links. These links connect the many image packet sources, Focal Plane Electronics (FPE), located near the cryogenic detectors to the processing electronics on the spacecraft structure. From 12 to 10,000 seconds of raw data are processed to make up an image, various algorithms integrate the pixel data Loss of commands to configure the detectors as well as the loss of science data itself may cause inefficiency in the use of the telescope that are unacceptable given the high cost of the observatory. This combination of requirements necessitates a redundant, fault tolerant, high- speed, low mass, low power network with a low Bit error Rate(1E-9- 1E-12). The ISIM systems team performed many studies of the various network architectures that meeting these requirements. The architecture selected uses the Spacewire protocol, with the addition of a new transport and network layer added to implement end-to-end reliable transport. The network and reliable transport mechanism must be implemented in hardware because of the high average information rate and the restriction on the ability of the detectors to buffer data due to power and size restrictions. This network and transport mechanism was designed to be compatible with existing Spacewire links and routers so that existing equipment and designs may be leveraged upon. The transport layer specification is being coordinated with European Space Agency (ESA), Spacewire Working Group and the Consultative Committee for Space Data System (CCSDS) PlK Standard Onboard Interface (SOIF) panel, with the intent of developing a standard for reliable transport for Spacewire. Changes to the protocol presented are likely since negotiations are ongoing with these groups. A block of RTL VHDL that implements a multi-port Spacewire router with an external user interface will be developed and integrated with an existing Spacewire Link design. The external user interface will be the local interface that sources and sinks packets onto and off of the network (Figure 3). The external user interface implements the network and transport layer and handles acknowledgements and re-tries of packets for reliable transport over the network. Because the design is written in RTL, it may be ported to any technology but will initially be targeted to the new Actel Accelerator series (AX) part. Each link will run at 160 Mbps and the power will be about 0.165 Watt per link worst case in the Actel AX.

[Simultaneous determinations of oxygen partial pressure in the scala tympani, electrocochleography and blood pressure measurements in noise stress in guinea pigs].

PubMed

Lamm, K; Lamm, C; Lamm, H; Schumann, K

1988-09-01

In 14 guinea pigs the pO2 in the perilymph of the scala tympani fell to 50%-80% of the original value during exposure to noise consisting of 4,000 Hz clicks with a repetition rate of 20/s, 100 dB CHL = 120 dB SPL p.e., repeated twice over a period of 24 minutes each time. For the measurements of the pO2 we used the thin 0.5 micron micro-coaxial needle electrode described by Baumgärtl and Luebbers, which was placed through the round-window membrane in the scala tympani to a depth of 600 micron. The simultaneously recorded CAP latency times were prolonged by 0.8 ms at a test loudness of 60 and 80 dB CHL. The amplitudes of the CM had declined by 60%-70% of the original values at a test loudness of 80 dB SPL p.e. The intra-arterial blood pressure in the common carotid artery of all animals remained constant. As the cortilymph spaces communicate with the perilymph of the scala tympani, our measured decline of pO2 in the perilymph could indicate a cortilymph hypoxia. During exposure to noise the oxygen-dependent Na+ and K+ pumps, which maintain the ion balance and function of the organ of Corti, can decompensate due to lack of oxygen. That would lead to a K+ contamination of the cortilymph and to an intracellular Na+ accumulation, which can cause microstructural damage (hair cell-cilia fusion, hair cell, synaptic and dendritic swelling, hair cell contraction and sustained depolarization), which would be reflected in the CMs and CAPs.

Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon.

PubMed

Seibt, Julie; Armant, Olivier; Le Digarcher, Anne; Castro, Diogo; Ramesh, Vidya; Journot, Laurent; Guillemot, François; Vanderhaeghen, Pierre; Bouschet, Tristan

2012-01-01

Imprinting is an epigenetic mechanism that restrains the expression of about 100 genes to one allele depending on its parental origin. Several imprinted genes are implicated in neurodevelopmental brain disorders, such as autism, Angelman, and Prader-Willi syndromes. However, how expression of these imprinted genes is regulated during neural development is poorly understood. Here, using single and double KO animals for the transcription factors Neurogenin2 (Ngn2) and Achaete-scute homolog 1 (Ascl1), we found that the expression of a specific subset of imprinted genes is controlled by these proneural genes. Using in situ hybridization and quantitative PCR, we determined that five imprinted transcripts situated at the Dlk1-Gtl2 locus (Dlk1, Gtl2, Mirg, Rian, Rtl1) are upregulated in the dorsal telencephalon of Ngn2 KO mice. This suggests that Ngn2 influences the expression of the entire Dlk1-Gtl2 locus, independently of the parental origin of the transcripts. Interestingly 14 other imprinted genes situated at other imprinted loci were not affected by the loss of Ngn2. Finally, using Ngn2/Ascl1 double KO mice, we show that the upregulation of genes at the Dlk1-Gtl2 locus in Ngn2 KO animals requires a functional copy of Ascl1. Our data suggest a complex interplay between proneural genes in the developing forebrain that control the level of expression at the imprinted Dlk1-Gtl2 locus (but not of other imprinted genes). This raises the possibility that the transcripts of this selective locus participate in the biological effects of proneural genes in the developing telencephalon.

Expression at the Imprinted Dlk1-Gtl2 Locus Is Regulated by Proneural Genes in the Developing Telencephalon

PubMed Central

Seibt, Julie; Armant, Olivier; Le Digarcher, Anne; Castro, Diogo; Ramesh, Vidya; Journot, Laurent; Guillemot, François; Vanderhaeghen, Pierre; Bouschet, Tristan

2012-01-01

Imprinting is an epigenetic mechanism that restrains the expression of about 100 genes to one allele depending on its parental origin. Several imprinted genes are implicated in neurodevelopmental brain disorders, such as autism, Angelman, and Prader-Willi syndromes. However, how expression of these imprinted genes is regulated during neural development is poorly understood. Here, using single and double KO animals for the transcription factors Neurogenin2 (Ngn2) and Achaete-scute homolog 1 (Ascl1), we found that the expression of a specific subset of imprinted genes is controlled by these proneural genes. Using in situ hybridization and quantitative PCR, we determined that five imprinted transcripts situated at the Dlk1-Gtl2 locus (Dlk1, Gtl2, Mirg, Rian, Rtl1) are upregulated in the dorsal telencephalon of Ngn2 KO mice. This suggests that Ngn2 influences the expression of the entire Dlk1-Gtl2 locus, independently of the parental origin of the transcripts. Interestingly 14 other imprinted genes situated at other imprinted loci were not affected by the loss of Ngn2. Finally, using Ngn2/Ascl1 double KO mice, we show that the upregulation of genes at the Dlk1-Gtl2 locus in Ngn2 KO animals requires a functional copy of Ascl1. Our data suggest a complex interplay between proneural genes in the developing forebrain that control the level of expression at the imprinted Dlk1-Gtl2 locus (but not of other imprinted genes). This raises the possibility that the transcripts of this selective locus participate in the biological effects of proneural genes in the developing telencephalon. PMID:23139813

Efficient lossy compression implementations of hyperspectral images: tools, hardware platforms, and comparisons

NASA Astrophysics Data System (ADS)

García, Aday; Santos, Lucana; López, Sebastián.; Callicó, Gustavo M.; Lopez, Jose F.; Sarmiento, Roberto

2014-05-01

Efficient onboard satellite hyperspectral image compression represents a necessity and a challenge for current and future space missions. Therefore, it is mandatory to provide hardware implementations for this type of algorithms in order to achieve the constraints required for onboard compression. In this work, we implement the Lossy Compression for Exomars (LCE) algorithm on an FPGA by means of high-level synthesis (HSL) in order to shorten the design cycle. Specifically, we use CatapultC HLS tool to obtain a VHDL description of the LCE algorithm from C-language specifications. Two different approaches are followed for HLS: on one hand, introducing the whole C-language description in CatapultC and on the other hand, splitting the C-language description in functional modules to be implemented independently with CatapultC, connecting and controlling them by an RTL description code without HLS. In both cases the goal is to obtain an FPGA implementation. We explain the several changes applied to the original Clanguage source code in order to optimize the results obtained by CatapultC for both approaches. Experimental results show low area occupancy of less than 15% for a SRAM-based Virtex-5 FPGA and a maximum frequency above 80 MHz. Additionally, the LCE compressor was implemented into an RTAX2000S antifuse-based FPGA, showing an area occupancy of 75% and a frequency around 53 MHz. All these serve to demonstrate that the LCE algorithm can be efficiently executed on an FPGA onboard a satellite. A comparison between both implementation approaches is also provided. The performance of the algorithm is finally compared with implementations on other technologies, specifically a graphics processing unit (GPU) and a single-threaded CPU.

Microscale In Vitro Assays for the Investigation of Neutral Red Retention and Ethoxyresorufin-O-Deethylase of Biofuels and Fossil Fuels.

PubMed

Heger, Sebastian; Bluhm, Kerstin; Brendt, Julia; Mayer, Philipp; Anders, Nico; Schäffer, Andreas; Seiler, Thomas-Benjamin; Hollert, Henner

Only few information on the potential toxic effectiveness of biofuels are available. Due to increasing worldwide demand for energy and fuels during the past decades, biofuels are considered as a promising alternative for fossil fuels in the transport sector. Hence, more information on their hazard potentials are required to understand the toxicological impact of biofuels on the environment. In the German Cluster of Excellence "Tailor-made Fuels from Biomass" design processes for economical, sustainable and environmentally friendly biofuels are investigated. In an unique and interdisciplinary approach, ecotoxicological methods are applied to gain information on potential adverse environmental effects of biofuels at an early phase of their development. In the present study, three potential biofuels, ethyl levulinate, 2-methyltetrahydrofuran and 2-methylfuran were tested. Furthermore, we investigated a fossil gasoline fuel, a fossil diesel fuel and an established biodiesel. Two in vitro bioassays, one for assessing cytotoxicity and one for aryl hydrocarbon receptor agonism, so called dioxin-like activity, as measured by Ethoxyresorufin-O-Deethylase, were applied using the permanent fish liver cell line RTL-W1 (Oncorhynchus mykiss). The special properties of these fuel samples required modifications of the test design. Points that had to be addressed were high substance volatility, material compatibility and low solubility. For testing of gasoline, diesel and biodiesel, water accommodated fractions and a passive dosing approach were tested to address the high hydrophobicity and low solubility of these complex mixtures. Further work has to focus on an improvement of the chemical analyses of the fuel samples to allow a better comparison of any effects of fossil fuels and biofuels.

Microscale In Vitro Assays for the Investigation of Neutral Red Retention and Ethoxyresorufin-O-Deethylase of Biofuels and Fossil Fuels

PubMed Central

Bluhm, Kerstin; Brendt, Julia; Mayer, Philipp; Anders, Nico; Schäffer, Andreas; Seiler, Thomas-Benjamin; Hollert, Henner

2016-01-01

Only few information on the potential toxic effectiveness of biofuels are available. Due to increasing worldwide demand for energy and fuels during the past decades, biofuels are considered as a promising alternative for fossil fuels in the transport sector. Hence, more information on their hazard potentials are required to understand the toxicological impact of biofuels on the environment. In the German Cluster of Excellence “Tailor-made Fuels from Biomass” design processes for economical, sustainable and environmentally friendly biofuels are investigated. In an unique and interdisciplinary approach, ecotoxicological methods are applied to gain information on potential adverse environmental effects of biofuels at an early phase of their development. In the present study, three potential biofuels, ethyl levulinate, 2-methyltetrahydrofuran and 2-methylfuran were tested. Furthermore, we investigated a fossil gasoline fuel, a fossil diesel fuel and an established biodiesel. Two in vitro bioassays, one for assessing cytotoxicity and one for aryl hydrocarbon receptor agonism, so called dioxin-like activity, as measured by Ethoxyresorufin-O-Deethylase, were applied using the permanent fish liver cell line RTL-W1 (Oncorhynchus mykiss). The special properties of these fuel samples required modifications of the test design. Points that had to be addressed were high substance volatility, material compatibility and low solubility. For testing of gasoline, diesel and biodiesel, water accommodated fractions and a passive dosing approach were tested to address the high hydrophobicity and low solubility of these complex mixtures. Further work has to focus on an improvement of the chemical analyses of the fuel samples to allow a better comparison of any effects of fossil fuels and biofuels. PMID:27684069

FPGA wavelet processor design using language for instruction-set architectures (LISA)

NASA Astrophysics Data System (ADS)

Meyer-Bäse, Uwe; Vera, Alonzo; Rao, Suhasini; Lenk, Karl; Pattichis, Marios

2007-04-01

The design of an microprocessor is a long, tedious, and error-prone task consisting of typically three design phases: architecture exploration, software design (assembler, linker, loader, profiler), architecture implementation (RTL generation for FPGA or cell-based ASIC) and verification. The Language for instruction-set architectures (LISA) allows to model a microprocessor not only from instruction-set but also from architecture description including pipelining behavior that allows a design and development tool consistency over all levels of the design. To explore the capability of the LISA processor design platform a.k.a. CoWare Processor Designer we present in this paper three microprocessor designs that implement a 8/8 wavelet transform processor that is typically used in today's FBI fingerprint compression scheme. We have designed a 3 stage pipelined 16 bit RISC processor (NanoBlaze). Although RISC μPs are usually considered "fast" processors due to design concept like constant instruction word size, deep pipelines and many general purpose registers, it turns out that DSP operations consume essential processing time in a RISC processor. In a second step we have used design principles from programmable digital signal processor (PDSP) to improve the throughput of the DWT processor. A multiply-accumulate operation along with indirect addressing operation were the key to achieve higher throughput. A further improvement is possible with today's FPGA technology. Today's FPGAs offer a large number of embedded array multipliers and it is now feasible to design a "true" vector processor (TVP). A multiplication of two vectors can be done in just one clock cycle with our TVP, a complete scalar product in two clock cycles. Code profiling and Xilinx FPGA ISE synthesis results are provided that demonstrate the essential improvement that a TVP has compared with traditional RISC or PDSP designs.

Mantle Recycling of Crustal Materials through Study of Ultrahigh-Pressure Minerals in Collisional Orogens, Ophiolites, and Xenoliths

NASA Astrophysics Data System (ADS)

Liou, J. G.; Tsujimori, T.; Yang, J.; Zhang, R. Y.; Ernst, W. G.

2014-12-01

Newly recognized ultrahigh-pressure (UHP) mineral occurrences including diamonds in ultrahigh-temperature (UHT) felsic granulites of orogenic belts, in chromitites associated with ophiolitic complexes, and in mafic/ultramafic xenoliths suggest the recycling of crustal materials through profound subduction, mantle upwelling, and return to the Earth's surface. Recycling is supported by unambiguously crust-derived mineral inclusions in deep-seated zircons, chromites, and diamonds from collision-type orogens, from eclogitic xenoliths, and from ultramafic bodies of several Alpine-Himalayan and Polar Ural ophiolites; some such phases contain low-atomic number elements typified by crustal isotopic signatures. Ophiolite-type diamonds in placer deposits and as inclusions in chromitites together with numerous highly reduced minerals and alloys appear to have formed near the mantle transition zone. In addition to ringwoodite and stishovite, a wide variety of nanometric minerals have been identified as inclusions employing state-of-the-art analysis. Reconstitution of now-exsolved precursor UHP phases and recognition of subtle decompression microstructures produced during exhumation reflect earlier UHP conditions. Some podiform chromitites and associated peridotites contain rare minerals of undoubted crustal origin, including Zrn, corundum, Fls, Grt, Ky, Sil, Qtz, and Rtl; the zircons possess much older U-Pb ages than the formation age of the host ophiolites. These UHP mineral-bearing chromitites had a deep-seated evolution prior to extensional mantle upwelling and its partial melting at shallow depths to form the overlying ophiolite complexes. These new findings plus stable isotopic and inclusion characteristics of diamonds provide compelling evidence for profound underflow of both oceanic and continental lithosphere, recycling of biogenic carbon into the lower mantle, and ascent to the Earth's surface through deep mantle ascent.

(Eco)toxicological effects of 2,4,7,9-tetramethyl-5-decyne-4,7-diol (TMDD) in zebrafish (Danio rerio) and permanent fish cell cultures.

PubMed

Vincze, Krisztina; Gehring, Martin; Braunbeck, Thomas

2014-01-01

2,4,7,9-tetramethyl-5-decyne-4,7-diol (TMDD) is a high-production volume chemical used in paper, ink, pesticide, and adhesive industries as a wetting and anti-foaming agent. The physicochemical properties and slow biodegradation rate of TMDD indicate a low bioaccumulation potential but a high prevalence in the environment. As a consequence, TMDD has been detected in several European rivers in the nanogram per liter and lower microgram per liter range; however, its environmental risk to aquatic organisms is considered low. Recent studies almost exclusively focused on acute effects by TMDD, little is known about cytotoxic and genotoxic effects, reproduction and developmental toxicity, endocrine disruption, and any kind of long-term toxicity and carcinogenicity so far. The present study aims to provide more specific baseline information on the ecotoxicological effects of TMDD in fish. For this end, cyto- and genotoxicity assays were carried out in vitro with the permanent fish cell line RTL-W1; in addition, in vivo studies were conducted with the early life stages of zebrafish (Danio rerio) in order to fill the data gaps in developmental toxicity and endocrine disruption. TMDD showed a cytotoxic and slight genotoxic potential in fish cell lines; moreover, various sublethal and lethal effects could be detected in developing zebrafish embryos. There was no evidence of endocrine-disrupting effects by TMDD; however, mortality following prolonged exposure to TMDD during fish sexual development test was clearly higher than mortality in the fish embryo test after 96-h exposure. Our results thus confirmed previous findings of laboratory screening tests, suggesting short-term toxic effects of TMDD in the intermediate, and long-term effects in the lower milligram per liter range.

Real-time operating system timing jitter and its impact on motor control

NASA Astrophysics Data System (ADS)

Proctor, Frederick M.; Shackleford, William P.

2001-12-01

General-purpose microprocessors are increasingly being used for control applications due to their widespread availability and software support for non-control functions like networking and operator interfaces. Two classes of real-time operating systems (RTOS) exist for these systems. The traditional RTOS serves as the sole operating system, and provides all OS services. Examples include ETS, LynxOS, QNX, Windows CE and VxWorks. RTOS extensions add real-time scheduling capabilities to non-real-time OSes, and provide minimal services needed for the time-critical portions of an application. Examples include RTAI and RTL for Linux, and HyperKernel, OnTime and RTX for Windows NT. Timing jitter is an issue in these systems, due to hardware effects such as bus locking, caches and pipelines, and software effects from mutual exclusion resource locks, non-preemtible critical sections, disabled interrupts, and multiple code paths in the scheduler. Jitter is typically on the order of a microsecond to a few tens of microseconds for hard real-time operating systems, and ranges from milliseconds to seconds in the worst case for soft real-time operating systems. The question of its significance on the performance of a controller arises. Naturally, the smaller the scheduling period required for a control task, the more significant is the impact of timing jitter. Aside from this intuitive relationship is the greater significance of timing on open-loop control, such as for stepper motors, than for closed-loop control, such as for servo motors. Techniques for measuring timing jitter are discussed, and comparisons between various platforms are presented. Techniques to reduce jitter or mitigate its effects are presented. The impact of jitter on stepper motor control is analyzed.

Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.

PubMed

Al Baqlani, Said Ali; Sy, Bui Tien; Ratsch, Boris A; Al Naamani, Khalid; Al Awaidy, Salah; Busaidy, Suleiman Al; Pauli, Georg; Bock, C-Thomas

2014-01-01

Hepatitis B virus (HBV) infection is a major global health burden with distinct geographic public health significance. Oman is a country with intermediate HBV carrier prevalence; however, little is known about the incidence of HBV variants in circulation. We investigated the HBV genotype distribution, the occurrence of antiviral resistance, and HBV surface antigen (HBsAg) escape mutations in HBsAg-positive patients in Oman. Serum samples were collected from 179 chronically HBV-infected patients enrolled in various gastroenterology clinics in Oman. HBV genotypes were determined by sequencing and phylogenetic analysis. Mutations in the HBV polymerase and the HBsAg gene were characterized by mutational analysis. HBV genotypes D (130/170; 76.47%) and A (32/170; 18.28%) are predominant in Oman. The HBV genotypes C and E were less frequent (each 1.18%), while the HBV genotypes B, G, F, and H were not detected. Four patients revealed HBV genotype mixtures (HBV-A/D and D/C). The analyses of vaccine escape mutations yield that 148/170 (87.06%) HBV sequences were wild type. 22/170 (12.94%) HBV sequences showed mutations in the "a" determinant of the HBsAg domain. Two patients showed the described HBV vaccine escape mutation sP120T. 8/146 (5.48%) HBV isolates harbored mutations in the HBV polymerase known to confer resistance against antiviral therapy. Especially the lamivudine resistance mutations rtL180M/rtM204V and rtM204I were detected. This study shows the distribution of HBV genotypes, therapy resistance, and vaccine escape mutations in HBV-infected patients in Oman. Our findings will have a major impact on therapy management and diagnostics of chronic HBV infections in Oman to control HBV infection in this intermediate HBV-endemic country.

Landscape of Fluid Sets of Hairpin-Derived 21-/24-nt-Long Small RNAs at Seed Set Uncovers Special Epigenetic Features in Picea glauca.

PubMed

Liu, Yang; El-Kassaby, Yousry A

2017-01-01

Conifers' exceptionally large genome (20-30 Gb) is scattered with 60% retrotransposon (RT) components and we have little knowledge on their origin and evolutionary implications. RTs may impede the expression of flanking genes and provide sources of the formation of novel small RNA (sRNAs) populations to constrain events of transposon (TE) proliferation/transposition. Here we show a declining expression of 24-nt-long sRNAs and low expression levels of their key processing gene, pgRTL2 (RNASE THREE LIKE 2) at seed set in Picea glauca. The sRNAs in 24-nt size class are significantly less enriched in type and read number than 21-nt sRNAs and have not been documented in other species. The architecture of MIR loci generating highly expressed 24-/21-nt sRNAs is featured by long terminal repeat-retrotransposons (LTR-RTs) in families of Ty3/Gypsy and Ty1/Copia elements. This implies that the production of sRNAs may be predominantly originated from TE fragments on chromosomes. Furthermore, a large proportion of highly expressed 24-nt sRNAs does not have predictable targets against unique genes in Picea, suggestive of their potential pathway in DNA methylation modifications on, for instance, TEs. Additionally, the classification of computationally predicted sRNAs suggests that 24-nt sRNA targets may bear particular functions in metabolic processes while 21-nt sRNAs target genes involved in many different biological processes. This study, therefore, directs our attention to a possible extrapolation that lacking of 24-nt sRNAs at the late conifer seed developmental phase may result in less constraints in TE activities, thus contributing to the massive expansion of genome size. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Ecotoxicological potential of the biocides terbutryn, octhilinone and methylisothiazolinone: Underestimated risk from biocidal pathways?

PubMed

Kresmann, Simon; Arokia, Arokia Hansel Rajan; Koch, Christoph; Sures, Bernd

2018-06-01

The use of biocides by industry, agriculture and households increased throughout the last two decades. Many new applications with known substances enriched the variety of biocidal pollution sources for the aquatic environment. While agriculture was the major source for a long time, leaching from building facades and preservation of personal care and cleaning products was identified as new sources in the last few years. With the different usage forms of biocidal products the complexity of legislative regulation increased as well. The requirements for risk assessment differ from one law to another and the potential risk of substances under different regulations might be underestimated. Still EC 50 and predicted no-effect concentration (PNEC) values gained from testing with different species are the core of environmental risk assessment, but ecotoxicological data is limited or lacking for many biocides. In this study the biocides widely used in facade coatings and household products terbutryn, octhilinone and methylisothiazolinone were tested with the Daphnia magna acute immobilisation assay, the neutral red uptake assay and the ethoxyresorufin-O-deethylase (EROD) assay, performed with rainbow trout liver (RTL-W1) cells. Further, the MTT assay with the ovarian cell line CHO-9 from Chinese hamster was used as mammalian model. Octhilinone induced the strongest effects with EC 50 values of 156μg/l in the D. magna assay, while terbutryn showed the weakest effects with 8390μg/l and methylisothiazolinone 513μg/l respectively. All other assays showed higher EC 50 values and thus only weak effects. EROD assays did not show any effects. With additional literature and database records PNEC values were calculated: terbutryn reached 0.003μg/l, octhilinone 0.05μg/l and methylisothiazolinone 0.5μg/l. Potential ecotoxicological risks of these biocides are discussed, considering environmental concentrations. Copyright © 2017 Elsevier B.V. All rights reserved.

Contribution of Priority PAHs and POPs to Ah Receptor-Mediated Activities in Sediment Samples from the River Elbe Estuary, Germany

PubMed Central

Otte, Jens C.; Keiter, Steffen; Faßbender, Christopher; Higley, Eric B.; Rocha, Paula Suares; Brinkmann, Markus; Wahrendorf, Dierk-Steffen; Manz, Werner; Wetzel, Markus A.; Braunbeck, Thomas; Giesy, John P.; Hecker, Markus; Hollert, Henner

2013-01-01

The estuary of the River Elbe between Hamburg and the North Sea (Germany) is a sink for contaminated sediment and suspended particulate matter (SPM). One major concern is the effect of human activities on the hydrodynamics, particularly the intensive dredging activities in this area that may result in remobilization of sediment-bound pollutants. The aim of this study was to identify pollutants contributing to the toxicological risk associated with re-suspension of sediments in the Elbe Estuary by use of an effect-directed analysis that combines chemical and biological analyses in with specific fractionation techniques. Sediments were collected from sites along the Elbe Estuary and a site from a small harbor basin of the Elbe Estuary that is known to be polluted. The sixteen priority EPA-PAHs were quantified in organic extracts of sediments. In addition, dioxin equivalents of sediments were investigated by use of the 7-ethoxyresorufin O-deethylase assay with RTL-W1 cells and the Ah receptor-mediated luciferase transactivation assay with H4IIE-luc cells. Quantification of the 16 priority PAHs revealed that sediments were moderately contaminated at all of the sites in the Elbe River Estuary (<0.02–0.906 µg/g dw). Sediments contained relatively small concentrations of dioxin equivalents (Bio-TEQ) with concentrations ranging from 15.5 to 322 pg/g dw, which were significantly correlated with dioxin equivalents calculated based on toxicity reference values and concentrations of PAH. The concentration of Bio-TEQ at the reference site exceeded 200,000 pg/g dw. In a potency balance the 16 PAHs explained between 47 and 118% of the Bio-TEQ in the luciferase assay, which can be explained by the constant input of PAHs bound to SPM from the upper course of the Elbe River into its estuary. Successful identification of a significant portion of dioxin-like activity to priority PAHs in complex environmental samples such as sediments has rarely been reported. PMID:24146763

Plasma proteins of rainbow trout (Oncorhynchus mykiss) isolated by binding to lipopolysaccharide from Aeromonas salmonicida.

PubMed

Hoover, G J; el-Mowafi, A; Simko, E; Kocal, T E; Ferguson, H W; Hayes, M A

1998-07-01

In an attempt to find plasma proteins that might be involved in the constitutive resistance of rainbow trout to furunculosis, a disease caused by Aeromonas salmonicida (AS), we purified serum and plasma proteins based on their calcium- and carbohydrate-dependent affinity for A. salmonicida lipopolysaccharide (LPS) coupled to an epoxy-activated synthetic matrix (Toyopearl AF Epoxy 650M). A multimeric family of high molecular weight (96 to 200-kDa) LPS-binding proteins exhibiting both calcium and mannose dependent binding was isolated. Upon reduction the multimers collapsed to subunits of approximately 16-kDa as estimated by 1D-PAGE and exhibited pI values of 5.30 and 5.75 as estimated from 2D-PAGE. Their N-terminal sequences were related to rainbow trout ladderlectin (RT-LL), a Sepharose-binding protein. Polyclonal antibodies to the LPS-purified 16-kDa subunits recognized both the reduced 16-kDa subunits and the non-reduced multimeric forms. A calcium- and N-acetylglucosamine (GlcNAc)-dependent LPS-binding multimeric protein (approximately 207-kDa) composed of 34.5-kDa subunits was purified and found to be identical to trout serum amyloid P (SAP) by N-terminal sequence (DLQDLSGKVFV). A protein of 24-kDa, in reduced and non-reduced conditions, was isolated and had N-terminal sequence identity with a known C-reactive protein (CRP) homologue, C-polysaccharide-binding protein 2 (TCBP2) of rainbow trout. A novel calcium-dependent LPS-binding protein was purified and termed rainbow trout lectin 37 (RT-L37). This protein, composed of dimers, tetramers and pentamers of 37 kDa subunits (pI 5.50-6.10) with N-terminal sequence (IQE(D/N)GHAEAPGATTVLNEILR) showed no close homology to proteins known or predicted from cDNA sequences. These findings demonstrate that rainbow trout have several blood proteins with lectin properties for the LPS of A. salmonicida; the biological functions of these proteins in resistance to furunculosis are still unknown.

Molecular Epidemiology and Genotyping of Hepatitis B Virus of HBsAg-Positive Patients in Oman

PubMed Central

Al Naamani, Khalid; Al Awaidy, Salah; Busaidy, Suleiman Al; Pauli, Georg; Bock, C.-Thomas

2014-01-01

Background Hepatitis B virus (HBV) infection is a major global health burden with distinct geographic public health significance. Oman is a country with intermediate HBV carrier prevalence; however, little is known about the incidence of HBV variants in circulation. We investigated the HBV genotype distribution, the occurrence of antiviral resistance, and HBV surface antigen (HBsAg) escape mutations in HBsAg-positive patients in Oman. Methods Serum samples were collected from 179 chronically HBV-infected patients enrolled in various gastroenterology clinics in Oman. HBV genotypes were determined by sequencing and phylogenetic analysis. Mutations in the HBV polymerase and the HBsAg gene were characterized by mutational analysis. Results HBV genotypes D (130/170; 76.47%) and A (32/170; 18.28%) are predominant in Oman. The HBV genotypes C and E were less frequent (each 1.18%), while the HBV genotypes B, G, F, and H were not detected. Four patients revealed HBV genotype mixtures (HBV-A/D and D/C). The analyses of vaccine escape mutations yield that 148/170 (87.06%) HBV sequences were wild type. 22/170 (12.94%) HBV sequences showed mutations in the “a” determinant of the HBsAg domain. Two patients showed the described HBV vaccine escape mutation sP120T. 8/146 (5.48%) HBV isolates harbored mutations in the HBV polymerase known to confer resistance against antiviral therapy. Especially the lamivudine resistance mutations rtL180M/rtM204V and rtM204I were detected. Conclusion This study shows the distribution of HBV genotypes, therapy resistance, and vaccine escape mutations in HBV-infected patients in Oman. Our findings will have a major impact on therapy management and diagnostics of chronic HBV infections in Oman to control HBV infection in this intermediate HBV-endemic country. PMID:24835494

Implications of Use of Coal-Tar-Based Pavement Sealcoat on Urban Water Quality

NASA Astrophysics Data System (ADS)

Van Metre, P. C.

2015-12-01

Coal-tar-based (CT) sealcoat is used to protect and improve the appearance of asphalt pavement of driveways and parking lots primarily in the central and eastern U.S. and in Canada. CT sealcoat typically is 20 to 35% crude coal tar or coal-tar pitch and contains from 50,000 to 100,000 mg/kg polycyclic aromatic hydrocarbons (PAH), about 1,000 times more than asphalt-based (AS) sealcoat or asphalt itself. Tires and snowplows abrade the friable sealcoat surface into fine particles—median total PAH concentrations in dust from CT-sealcoated pavement are 2,200 mg/kg compared to a median concentration of 11 mg/kg for dust from unsealed pavement. Use of CT sealcoat has several implications for urban streams and lakes. Source apportionment modeling has indicated that, in regions where CT sealcoat is prevalent, particles from sealcoated pavement are contributing the majority of the PAHs to recently deposited lake sediment, often resulting in sediment concentrations above toxicity thresholds based on effects-based sediment quality guidelines. Acute 2-day laboratory toxicity testing of simulated runoff from CT-sealcoated pavement to a cladoceran (Ceriodaphnia dubia) and fathead minnows (Pimephales promelas) demonstrated that toxicity continues for samples collected for weeks or months following sealcoat application and that toxicity is enhanced by exposure to UV light. Using the fish-liver cell line RTL-W1, runoff collected as much as 36 days following CT-sealcoat application has been demonstrated to cause DNA damage and impair DNA repair capacity. These results demonstrate that CT runoff is a potential hazard to aquatic ecosystems and that exposure to sunlight can enhance toxicity and genetic damage. Recent research has provided direct evidence that restricting use of CT sealcoat in a watershed can lead to a substantial reduction in PAH concentrations in receiving water bodies.

Evaluation of nursing faculty through observation.

PubMed

Crawford, L H

1998-10-01

The purpose of this study was to assess current use and faculty perceptions of classroom observation as a method of faculty evaluation in schools of nursing. Baccalaureate schools of nursing were surveyed to determine current use of classroom observation and its worth from the perception of administrators and faculty. Although most schools used classroom observation as a method of faculty evaluation, further clarification and research is needed in the following areas: purpose of classroom observation; number of observations necessary; weight given to classroom observation in relation to other evaluation methods; and tools used.

"Evaluations" of Observables Versus Measurements in Quantum Theory

NASA Astrophysics Data System (ADS)

Nisticò, Giuseppe; Sestito, Angela

2016-03-01

In Quantum Physics there are circumstances where the direct measurement of a given observable encounters difficulties; in some of these cases, however, its value can be "evaluated", i.e. it can be inferred by measuring another observable characterized by perfect correlation with the observable of interest. Though an evaluation is often interpreted as a measurement of the evaluated observable, we prove that the two concepts cannot be identified in Quantum Physics, because the identification yields contradictions. Then, we establish the conceptual status of evaluations in Quantum Theory and how they are related to measurements.

Teacher Evaluations: Do Classroom Observations and Evaluator Training Really Matter?

ERIC Educational Resources Information Center

Pies, Sarah J.

2017-01-01

The purpose of this study was to determine if the minimum number of observations stated in a district's teacher evaluation plan, observation characteristics described in a district's evaluation plan, and the characteristic of those evaluating teachers had an impact on whether a school would receive a bonus or penalty point for Indiana's A-F…

Guidelines for reporting evaluations based on observational methodology.

PubMed

Portell, Mariona; Anguera, M Teresa; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana

2015-01-01

Observational methodology is one of the most suitable research designs for evaluating fidelity of implementation, especially in complex interventions. However, the conduct and reporting of observational studies is hampered by the absence of specific guidelines, such as those that exist for other evaluation designs. This lack of specific guidance poses a threat to the quality and transparency of these studies and also constitutes a considerable publication hurdle. The aim of this study thus was to draw up a set of proposed guidelines for reporting evaluations based on observational methodology. The guidelines were developed by triangulating three sources of information: observational studies performed in different fields by experts in observational methodology, reporting guidelines for general studies and studies with similar designs to observational studies, and proposals from experts in observational methodology at scientific meetings. We produced a list of guidelines grouped into three domains: intervention and expected outcomes, methods, and results. The result is a useful, carefully crafted set of simple guidelines for conducting and reporting observational studies in the field of program evaluation.

Quality Assurance in Department of Defense Financial Management Education and Training Institutions

DTIC Science & Technology

1992-09-01

Training Course. 24 *22. Do you use classroom observation to evaluate instruction? RESPONSE NUMBER PERCENTAGE YES 17 89.5 NO 2 10.5 TOTAL RESPONSES 19...evaluate classroom instruction? (Note: Question 23 asks whether respondents use classroom observation to evaluate instruction] (15 responses...as follows: " Question 22: Do you use classroom observation to evaluate instruction? (17 responses) " Question 23: Are other methods used to evaluate

Measurements of observables replaced by “evaluations” in Quantum Theory

NASA Astrophysics Data System (ADS)

Nisticò, Giuseppe; Sestito, Angela

2015-07-01

In quantum physics there are circumstances where the direct measurement of particular observables encounters difficulties; in some of these cases, however, its value can be evaluated, i.e. it can be inferred by measuring another observable characterized by perfect correlation with the observable of interest. Though an evaluation is often interpreted as a measurement of the evaluated observable, we prove that the two concepts cannot be identified in quantum physics, because the identification yields contradictions. Then, we establish the conceptual status of evaluations in Quantum Theory and the role can be ascribed to them.

Evaluating Music Teachers: A Comparison of Evaluations by Observers with Varied Levels of Musical and Observational Background

ERIC Educational Resources Information Center

Hirokawa, Joy Ondra

2013-01-01

The purpose of this research was to examine the differences in the evaluations of music teachers conducted by individuals with varying backgrounds in music and observation techniques. Part I compared evaluations completed by school administrators and music department leadership. Part II utilized the findings of Part I to create focused and…

Tip of the Tongue States Increase Under Evaluative Observation.

PubMed

James, Lori E; Schmank, Christopher J; Castro, Nichol; Buchanan, Tony W

2018-02-01

We tested the frequent assumption that the difficulty of word retrieval increases when a speaker is being observed and evaluated. We modified the Trier Social Stress Test (TSST) so that participants believed that its evaluative observation components continued throughout the duration of a subsequent word retrieval task, and measured participants' reported tip of the tongue (TOT) states. Participants in this TSST condition experienced more TOTs than participants in a comparable, placebo TSST condition in which there was no suggestion of evaluative observation. This experiment provides initial evidence confirming the assumption that evaluative observation by a third party can be disruptive to word retrieval. We interpret our findings by proposing an extension to a well-supported theoretical model of TOTs.

Analysing Surface Exposure to Climate Dynamics in the Himalayas to Adopt a Planning Framework for Landslide Risk Reduction

NASA Astrophysics Data System (ADS)

Tiwari, A.

2017-12-01

Himalayas rank first in the inventory of most densely populated and congested high altitude mountain regions of the planet. The region is mostly characterized by inadequate infrastructure, lack of mitigation tools along with constraints of terrain undermining the carrying capacity and resilience of urban ecosystems. Moreover, climate change has increased vulnerability of poor and marginalized population living in rapidly urbanizing mountain towns to increased frequency and severity of risks from extreme weather events. Such events pose multifold threat by easily translating to hazards, without the ability to respond and mitigate. Additionally, the recent extreme climate dynamics such as rainfall patterns have influenced the natural rate of surface/slope processes in the Himalaya. The aim of the study was to analyze the extent of interaction between climate dynamics and upland surface to develop participatory planning framework for landslide risk reduction using Integral Geographic Information System (integral GIS). At this stage, the study is limited to only rainfall triggered landslides (RTL). The study region lies in the middle Himalayan range (Himachal). Research utilized terrain analysis tools in integral GIS and identified risk susceptible surface without: 1.adding to its (often) complex fragmentation, and 2. Interference in surface/slope processes. Analysis covered most of the relevant surface factors including geology, slope instability, infrastructure development, natural and urban drainage system, land-cover and land-use as well. The outcome included an exposure-reduced model of existing terrain and the surface-process accommodated by it, with the use of local technical tools available among the poor and fragile mountain community. The final participatory planning framework successfully harmonized people's perception and adaptation knowledge, and incorporated priorities of local authorities. This research is significant as it rises above the fundamental challenges arising during management of the (often) conflicting perspectives, interests, and approaches of multiplicity of stakeholders thereby having vast potential to replicate/upscale in mountains beyond the study region as it ensures barrier free risk-communication through the most affordable and innovative tools.

Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations

PubMed Central

2011-01-01

Background Complex mutants can be selected under sequential selective pressure by HBV therapy. To determine hepatitis B virus genomic evolution during antiviral therapy we characterized the HBV quasi-species in a patient who did no respond to therapy following lamivudine breakthrough for a period of 14 years. Case Presentation The polymerase and precore/core genes were amplified and sequenced at determined intervals in a period of 14 years. HBV viral load and HBeAg/Anti-HBe serological profiles as well as amino transferase levels were also measured. A mixture of lamivudine-resistant genotype A2 HBV strains harboring the rtM204V mutation coexisted in the patient following viral breakthrough to lamivudine. The L180M+M204V dominant mutant displayed strong lamivudine-resistance. As therapy was changed to adefovir, then to entecavir, and finally to entecavir-tenofovir the viral load showed fluctuations but lamivudine-resistant strains continued to be selected, with minor contributions to the HBV quasi-species composition of additional resistance-associated mutations. At the end of the 14-year follow up period, high viral loads were predominant, with viral strains harboring the lamivudine-resistance signature rtL180M+M204V. The precore/core frame A1762T and G1764A double mutation was detected before treatment and remaining in this condition during the entire follow-up. Specific entecavir and tenofovir primary resistance-associated mutations were not detected at any time. Plasma concentrations of tenofovir indicated adequate metabolism of the drug. Conclusions We report the selection of HBV mutants carrying well-defined primary resistance mutations that escaped lamivudine in a fourteen-year follow-up period. With the exception of tenofovir resistance mutations, subsequent unselected primary resistance mutations were detected as minor populations into the HBV quasispecies composition during adefovir or entecavir monotherapies. Although tenofovir is considered an appropriate therapeutic alternative for the treatment of entecavir-unresponsive patients, its use was not effective in the case reported here. PMID:21696601

Java Image I/O for VICAR, PDS, and ISIS

NASA Technical Reports Server (NTRS)

Deen, Robert G.; Levoe, Steven R.

2011-01-01

This library, written in Java, supports input and output of images and metadata (labels) in the VICAR, PDS image, and ISIS-2 and ISIS-3 file formats. Three levels of access exist. The first level comprises the low-level, direct access to the file. This allows an application to read and write specific image tiles, lines, or pixels and to manipulate the label data directly. This layer is analogous to the C-language "VICAR Run-Time Library" (RTL), which is the image I/O library for the (C/C++/Fortran) VICAR image processing system from JPL MIPL (Multimission Image Processing Lab). This low-level library can also be used to read and write labeled, uncompressed images stored in formats similar to VICAR, such as ISIS-2 and -3, and a subset of PDS (image format). The second level of access involves two codecs based on Java Advanced Imaging (JAI) to provide access to VICAR and PDS images in a file-format-independent manner. JAI is supplied by Sun Microsystems as an extension to desktop Java, and has a number of codecs for formats such as GIF, TIFF, JPEG, etc. Although Sun has deprecated the codec mechanism (replaced by IIO), it is still used in many places. The VICAR and PDS codecs allow any program written using the JAI codec spec to use VICAR or PDS images automatically, with no specific knowledge of the VICAR or PDS formats. Support for metadata (labels) is included, but is format-dependent. The PDS codec, when processing PDS images with an embedded VIAR label ("dual-labeled images," such as used for MER), presents the VICAR label in a new way that is compatible with the VICAR codec. The third level of access involves VICAR, PDS, and ISIS Image I/O plugins. The Java core includes an "Image I/O" (IIO) package that is similar in concept to the JAI codec, but is newer and more capable. Applications written to the IIO specification can use any image format for which a plug-in exists, with no specific knowledge of the format itself.

Tip of the Tongue States Increase under Evaluative Observation

ERIC Educational Resources Information Center

James, Lori E.; Schmank, Christopher J.; Castro, Nichol; Buchanan, Tony W.

2018-01-01

We tested the frequent assumption that the difficulty of word retrieval increases when a speaker is being observed and evaluated. We modified the Trier Social Stress Test (TSST) so that participants believed that its evaluative observation components continued throughout the duration of a subsequent word retrieval task, and measured participants'…

Atmospheric Model Evaluation Tool for meteorological and air quality simulations

EPA Pesticide Factsheets

The Atmospheric Model Evaluation Tool compares model predictions to observed data from various meteorological and air quality observation networks to help evaluate meteorological and air quality simulations.

Department of Defense Financial Management Education and Training Programs: A Survey of Quality Assurance Methods

DTIC Science & Technology

1992-06-01

CRITERIA TO HIRE CIVILIANS 10 21. PROFESSIONAL QUALIFICATION STANDARDS 18 22. CLASSROOM OBSERVATION 19 23. OTHER METHODS TO EVALUATE 18 INSTRUCTION 24. OTHER...other methods used to evaluate classroom instruction? (Note: Question 23 asks whether respondents use classroom observation to evaluate instruction] (15...number of affirmative responses are as follows: "* Question 22: Do you use classroom observation to evaluate instruction? (17 responses) "* Question

Intra- and inter-observer reliability of ten major histological scoring systems used for the evaluation of in vivo cartilage repair.

PubMed

Bonasia, Davide Edoardo; Marmotti, Antongiulio; Massa, Alessandro Domenico Felice; Ferro, Andrea; Blonna, Davide; Castoldi, Filippo; Rossi, Roberto

2015-09-01

In the last two decades, many surgical techniques have been described for articular cartilage repair. Reliable histological scoring systems are fundamental tools to evaluate new procedures. Several histological scoring systems have been described, and these can be divided in elementary and comprehensive scores, according to the number of sub-items. The aim of this study was to test the inter- and intra-observer reliability of ten main scores used for the histological evaluation of in vivo cartilage repair. The authors tested the starting hypothesis that elementary scores would show superior intra- and inter-observer reliability compared with comprehensive scores. Fifty histological sections obtained from the trochlea of New Zealand Rabbit and stained with Safranin-O fast green were used. The histological sections were analysed by 4 observers: 2 experienced in cartilage histology and 2 inexperienced. Histological evaluations were performed at time 1 and time 2, separated by a 30-day interval. The following scores were used: Mankin, O'Driscoll, Pineda, Wakitani, Fortier, Selleres, ICRS, ICRSII, Oswestry (OsScore) and modified O'Driscoll. Intra- and inter-observer reliability were evaluated for each score. In addition, the pavement-ceiling effect and the Bland-Altman Coefficient of Repeatability were then evaluated for each sub-item of every score. Intra-observer reliability was high for all observers in every score, even though the reliability was significantly lower for non-expert observers compared with expert counterparts. In terms of Coefficient of Repeatability, some scores performed better (O'Driscoll, Modified O'Driscoll and ICRSII) than others (Fortier, Seller). Inter-observer reliability was high for all observers in every score, but significantly lower for non-expert compared with expert observers. In expert hands, all the scores showed high intra- and inter-observer reliability, independently of the complexity. Although every score has advantages and disadvantages, ICRSII, O'Driscoll and Modified O'Driscoll scores should be preferred for the evaluation of in vivo cartilage repair in animal models.

Colour evaluation in scars: tristimulus colorimeter, narrow-band simple reflectance meter or subjective evaluation?

PubMed

Draaijers, Lieneke J; Tempelman, Fenike R H; Botman, Yvonne A M; Kreis, Robert W; Middelkoop, Esther; van Zuijlen, Paul P M

2004-03-01

The evaluation of scar colour is, at present, usually limited to an assessment according to a scar assessment scale. Although useful, these assessment scales only evaluate subjectively the degree of scar colour. In this study, the reliability of the subjective assessment of scar colour by observers is compared to the reliability of the measurements of two objective colour measurement instruments. Four independent observers subjectively assessed the vascularisation and pigmentation of 49 scar areas in 20 patients. The degree of vascularisation and pigmentation was scored according to a scale ranging from '1', when it appeared to be like healthy skin, to '10', which corresponds to the worst imaginable outcome of vascularisation or pigmentation. The observers also scored the pigmentation categories of the scar (hypopigmention, hyperpigmention or mixed pigmentation). Finally, each observer measured the scar areas with a tristimulus colorimeter (Minolta Chromameter) and a narrow-band simple reflectance meter (DermaSpectrometer). A single observer could reliably carry out measurements of the DermaSpectrometer and the Minolta Chromameter for the evaluation of scar colour (r = 0.72). The vascularisation of scars could also be assessed reliably with a single observer (r = 0.76) whereas for a reliable assessment of pigmentation at least three observers were necessary (r > or = 0.77). The agreement between the observers for the pigmentation categories also turned out to be unacceptably low (k = 0.349). This study shows that an overall evaluation of scar colour with the DermaSpectrometer and the Minolta Chromameter is more reliable than the evaluation of scar colour with observers. Of both instruments for measuring scar colour, we prefer, because of its feasibility, the DermaSpectrometer.

Cluster signal-to-noise analysis for evaluation of the information content in an image.

PubMed

Weerawanich, Warangkana; Shimizu, Mayumi; Takeshita, Yohei; Okamura, Kazutoshi; Yoshida, Shoko; Yoshiura, Kazunori

2018-01-01

(1) To develop an observer-free method of analysing image quality related to the observer performance in the detection task and (2) to analyse observer behaviour patterns in the detection of small mass changes in cone-beam CT images. 13 observers detected holes in a Teflon phantom in cone-beam CT images. Using the same images, we developed a new method, cluster signal-to-noise analysis, to detect the holes by applying various cut-off values using ImageJ and reconstructing cluster signal-to-noise curves. We then evaluated the correlation between cluster signal-to-noise analysis and the observer performance test. We measured the background noise in each image to evaluate the relationship with false positive rates (FPRs) of the observers. Correlations between mean FPRs and intra- and interobserver variations were also evaluated. Moreover, we calculated true positive rates (TPRs) and accuracies from background noise and evaluated their correlations with TPRs from observers. Cluster signal-to-noise curves were derived in cluster signal-to-noise analysis. They yield the detection of signals (true holes) related to noise (false holes). This method correlated highly with the observer performance test (R 2 = 0.9296). In noisy images, increasing background noise resulted in higher FPRs and larger intra- and interobserver variations. TPRs and accuracies calculated from background noise had high correlation with actual TPRs from observers; R 2 was 0.9244 and 0.9338, respectively. Cluster signal-to-noise analysis can simulate the detection performance of observers and thus replace the observer performance test in the evaluation of image quality. Erroneous decision-making increased with increasing background noise.

The Domain Five Observation Instrument: A Competency-Based Coach Evaluation Tool

ERIC Educational Resources Information Center

Shangraw, Rebecca

2017-01-01

The Domain Five Observation Instrument (DFOI) is a competency-based observation instrument recommended for sport leaders or researchers who wish to evaluate coaches' instructional behaviors. The DFOI includes 10 behavior categories and four timed categories that encompass 34 observable instructional benchmarks outlined in domain five of the…

Evaluating Behavioural Observation Audiometry with Handicapped Children.

ERIC Educational Resources Information Center

Flexer, Carol; Gans, Donald P.

1982-01-01

Three observers evaluated the responses to sound with 21 mild to severely handicapped children (7 months to 10 years old) on Behavioural Observation Audiometry, an alternative to conditioning paradigms in audiometric assessment. Results showed that inter-observer agreement was high and that responsitivity was not affected by stimulus presentation…

Inter-observer and intra-observer agreement on interpretation of uroflowmetry curves of kindergarten children.

PubMed

Chang, Shang-Jen; Yang, Stephen S D

2008-12-01

To evaluate the inter-observer and intra-observer agreement on the interpretation of uroflowmetry curves of children. Healthy kindergarten children were enrolled for evaluation of uroflowmetry. Uroflowmetry curves were classified as bell-shaped, tower, plateau, staccato and interrupted. Only the bell-shaped curves were regarded as normal. Two urodynamists evaluated the curves independently after reviewing the definitions of the different types of uroflowmetry curve. The senior urodynamist evaluated the curves twice 3 months apart. The final conclusion was made when consensus was reached. Agreement among observers was analyzed using kappa statistics. Of 190 uroflowmetry curves eligible for analysis, the intra-observer agreement in interpreting each type of curve and interpreting normalcy vs abnormality was good (kappa=0.71 and 0.68, respectively). Very good inter-observer agreement (kappa=0.81) on normalcy and good inter-observer agreement (kappa=0.73) on types of uroflowmetry were observed. Poor inter-observer agreement existed on the classification of specific types of abnormal uroflowmetry curves (kappa=0.07). Uroflowmetry is a good screening tool for normalcy of kindergarten children, while not a good tool to define the specific types of abnormal uroflowmetry.

[Inferential evaluation of intimacy based on observation of interpersonal communication].

PubMed

Kimura, Masanori

2015-06-01

How do people inferentially evaluate others' levels of intimacy with friends? We examined the inferential evaluation of intimacy based on the observation of interpersonal communication. In Experiment 1, participants (N = 41) responded to questions after observing conversations between friends. Results indicated that participants inferentially evaluated not only goodness of communication, but also intimacy between friends, using an expressivity heuristic approach. In Experiment 2, we investigated how inferential evaluation of intimacy was affected by prior information about relationships and by individual differences in face-to-face interactional ability. Participants (N = 64) were divided into prior- and no-prior-information groups and all performed the same task as in Experiment 1. Additionally, their interactional ability was assessed. In the prior-information group, individual differences had no effect on inferential evaluation of intimacy. On the other hand, in the no-prior-information group, face-to-face interactional ability partially influenced evaluations of intimacy. Finally, we discuss the fact that to understand one's social environment, it is important to observe others' interpersonal communications.

Evaluation of NCAR CAM5 Simulated Marine Boundary Layer Cloud Properties Using a Combination of Satellite and Surface Observations

NASA Astrophysics Data System (ADS)

Zhang, Z.; Song, H.; Wang, M.; Ghan, S. J.; Dong, X.

2016-12-01

he main objective of this study is to systematically evaluate the MBL cloud properties simulated in CAM5 family models using a combination of satellite-based CloudSat/MODIS observations and ground-based observations from the ARM Azores site, with a special focus on MBL cloud microphysics and warm rain process. First, we will present a global evaluation based on satellite observations and retrievals. We will compare global cloud properties (e.g., cloud fraction, cloud vertical structure, cloud CER, COT, and LWP, as well as drizzle frequency and intensity diagnosed using the CAM5-COSP instrumental simulators) simulated in the CAM5 models with the collocated CloudSat and MODIS observations. We will also present some preliminary results from a regional evaluation based mainly on ground observations from ARM Azores site. We will compare MBL cloud properties simulated in CAM5 models over the ARM Azores site with collocated satellite (MODIS and CloudSat) and ground-based observations from the ARM site.

The implementation of a mobile problem-specific electronic CEX for assessing directly observed student-patient encounters.

PubMed

Ferenchick, Gary S; Foreback, Jami; Towfiq, Basim; Kavanaugh, Kevin; Solomon, David; Mohmand, Asad

2010-01-29

Facilitating direct observation of medical students' clinical competencies is a pressing need. We developed an electronic problem-specific Clinical Evaluation Exercise (eCEX) based on a national curriculum. We assessed its feasibility in monitoring and recording students' competencies and the impact of a grading incentive on the frequency of direct observations in an internal medicine clerkship. Students (n = 56) at three clinical sites used the eCEX and comparison students (n = 56) at three other clinical sites did not. Students in the eCEX group were required to arrange 10 evaluations with faculty preceptors. Students in the second group were required to document a single, faculty observed 'Full History and Physical' encounter with a patient. Students and preceptors were surveyed at the end of each rotation. eCEX increased students' and evaluators' understanding of direct-observation objectives and had a positive impact on the evaluators' ability to provide feedback and assessments. The grading incentive increased the number of times a student reported direct observation by a resident preceptor. eCEX appears to be an effective means of enhancing student evaluation.

Increasing community capacity for participatory evaluation of healthy eating and active living strategies through direct observations and environmental audits.

PubMed

Kemner, Allison L; Stachecki, Jessica R; Bildner, Michele E; Brennan, Laura K

2015-01-01

Local partnerships from the Healthy Kids, Healthy Communities initiative elected to participate in enhanced evaluation trainings to collect data through environmental audits and direct observations as well as to build their evaluation capacity. Environmental audit and direct observation tools and protocols were adapted for the relevant healthy eating and active living policy and environmental change approaches being conducted by the Healthy Kids, Healthy Communities partnerships. Customized trainings were conducted by the evaluation team to increase capacity and understanding for evaluation activities. A total of 87 trainings were conducted by the evaluation team in 31 Healthy Kids, Healthy Communities community partnerships. Data were collected for a total of 41 environmental audits and 17 direct observations. Community case examples illustrate how these trainings developed evaluation capacity. For instance, youth from one community presented environmental audit findings to local elected officials. The 31 partnerships participating in the community-based evaluation efforts resulted in 164 individuals trained in collecting context-specific data to assess the impact of healthy eating and active living policy and environmental strategies designed to create community change.

Evaluation of CNN as anthropomorphic model observer

NASA Astrophysics Data System (ADS)

Massanes, Francesc; Brankov, Jovan G.

2017-03-01

Model observers (MO) are widely used in medical imaging to act as surrogates of human observers in task-based image quality evaluation, frequently towards optimization of reconstruction algorithms. In this paper, we explore the use of convolutional neural networks (CNN) to be used as MO. We will compare CNN MO to alternative MO currently being proposed and used such as the relevance vector machine based MO and channelized Hotelling observer (CHO). As the success of the CNN, and other deep learning approaches, is rooted in large data sets availability, which is rarely the case in medical imaging systems task-performance evaluation, we will evaluate CNN performance on both large and small training data sets.

Lessons from cross-fleet/cross-airline observations - Evaluating the impact of CRM/LOFT training

NASA Technical Reports Server (NTRS)

Butler, Roy E.

1991-01-01

A review is presented of the crew resource management/line oriented flight training (CRM/LOFT) program to help determine the level of standardization across fleets and airlines in the critical area of evaluating crew behavior and performance. One of the goals of the project is to verify that check airmen and LOFT instructors within organizations are evaluating CRM issues consistently and that differences observed between fleets are not a function of idiosyncracies on the part of observers. Attention is given to the research tools for crew evaluation.

Postflight hardware evaluation 360T021 (RSRM-21, STS-45), revision A

NASA Technical Reports Server (NTRS)

Maccauly, Linda E.

1992-01-01

The Final Postflight Hardware Evaluation Report 360T021 (RSRM-21, STS-45) is included. All observed hardware conditions were documented on Postflight Observation Reports (PFOR's) and included in Appendices A through E. This report, along with the KSC Ten-Day Postflight Hardware Evaluation Report represents a summary of the 360T021 hardware evaluation.

Building a More Complete Understanding of Teacher Evaluation Using Classroom Observations

ERIC Educational Resources Information Center

Cohen, Julie; Goldhaber, Dan

2016-01-01

Improving teacher evaluation is one of the most pressing but also contested areas of educational policy. Value-added measures have received much of the attention in new evaluation systems, but they can only be used to evaluate a fraction of teachers. Classroom observations are almost universally used to assess teachers, yet their statistical…

A new method to evaluate image quality of CBCT images quantitatively without observers

PubMed Central

Shimizu, Mayumi; Okamura, Kazutoshi; Yoshida, Shoko; Weerawanich, Warangkana; Tokumori, Kenji; Jasa, Gainer R; Yoshiura, Kazunori

2017-01-01

Objectives: To develop an observer-free method for quantitatively evaluating the image quality of CBCT images by applying just-noticeable difference (JND). Methods: We used two test objects: (1) a Teflon (polytetrafluoroethylene) plate phantom attached to a dry human mandible; and (2) a block phantom consisting of a Teflon step phantom and an aluminium step phantom. These phantoms had holes with different depths. They were immersed in water and scanned with a CB MercuRay (Hitachi Medical Corporation, Tokyo, Japan) at tube voltages of 120 kV, 100 kV, 80 kV and 60 kV. Superimposed images of the phantoms with holes were used for evaluation. The number of detectable holes was used as an index of image quality. In detecting holes quantitatively, the threshold grey value (ΔG), which differentiated holes from the background, was calculated using a specific threshold (the JND), and we extracted the holes with grey values above ΔG. The indices obtained by this quantitative method (the extracted hole values) were compared with the observer evaluations (the observed hole values). In addition, the contrast-to-noise ratio (CNR) of the shallowest detectable holes and the deepest undetectable holes were measured to evaluate the contribution of CNR to detectability. Results: The results of this evaluation method corresponded almost exactly with the evaluations made by observers. The extracted hole values reflected the influence of different tube voltages. All extracted holes had an area with a CNR of ≥1.5. Conclusions: This quantitative method of evaluating CBCT image quality may be more useful and less time-consuming than evaluation by observation. PMID:28045343

Teacher Evaluation: The Limits of Looking.

ERIC Educational Resources Information Center

Stodolsky, Susan S.

1984-01-01

Reviews current teacher evaluation practices with particular focus on the use of observation. Argues that direct observation is an inadequate evaluation technique because it assumes that stability and consistency are necessary for effective teaching. Presents data showing that flexibility is a more accurate characterization of elementary level…

Teacher Evaluation.

ERIC Educational Resources Information Center

Millard, Joseph E.

Teachers may be evaluated (1) according to their skills and attitudes, (2) by observing their behavior, (3) observing the students' behavior and achievement, and (4) by a combination of means. Some systems, summative and formative, now enjoying rather wide popularity are described in this document. IOTA (Instrument for Observation of Teaching…

Syndromic craniosynostosis: neuropsycholinguistic abilities and imaging analysis of the central nervous system.

PubMed

Maximino, Luciana Paula; Ducati, Luis Gustavo; Abramides, Dagma Venturini Marques; Corrêa, Camila de Castro; Garcia, Patrícia Fernandes; Fernandes, Adriano Yacubian

2017-12-01

To characterize patients with syndromic craniosynostosis with respect to their neuropsycholinguistic abilities and to present these findings together with the brain abnormalities. Eighteen patients with a diagnosis of syndromic craniosynostosis were studied. Eight patients had Apert syndrome and 10 had Crouzon syndrome. They were submitted to phonological evaluation, neuropsychological evaluation and magnetic resonance imaging of the brain. The phonological evaluation was done by behavioral observation of the language, the Peabody test, Token test and a school achievement test. The neuropsychological evaluation included the WISC III and WAIS tests. Abnormalities in language abilities were observed and the school achievement test showed abnormalities in 66.67% of the patients. A normal intelligence quotient was observed in 39.3% of the patients, and congenital abnormalities of the central nervous system were observed in 46.4% of the patients. Abnormalities of language abilities were observed in the majority of patients with syndromic craniosynostosis, and low cognitive performance was also observed.

Validation of the Italian version of the Coma Recovery Scale-Revised (CRS-R).

PubMed

Sacco, Simona; Altobelli, Emma; Pistarini, Caterina; Cerone, Davide; Cazzulani, Benedetta; Carolei, Antonio

2011-01-01

To validate the Italian version of the Coma Recovery Scale-Revised (CRS-R). Two observers applied the Italian version of the CRS-R to selected patients. On day 1, observer A and B independently scored each patient; the comparison of their observations was used to evaluate inter-observer agreement. On day 2, observer A completed a second evaluation and the comparison of this observation with that obtained on day 1 by the same observer was used to evaluate test-re-test agreement. For each evaluation, also diagnostic impression (vegetative state/minimally conscious state) was reported. Thirty-eight patients were evaluated (mean age ± SD, 58.9 ± 13.8 years). Inter-observer (ρ = 0.81; p < 0.001) as well as test-re-test agreement (ρ = 0.97; p < 0.001) for the total score was high. Inter-observer agreement was excellent for the communication sub-scale, good for the auditory, visual and motor sub-scales and moderate for the oromotor/verbal and arousal sub-scales. Test-re-test agreement was excellent for the visual, motor, oromotor/verbal and communication sub-scales, good for the auditory sub-scale and moderate for the arousal sub-scale. When considering the diagnostic impression, inter-observer agreement was good (κ = 0.75; p < 0.001) and test-re-test agreement was excellent (κ = 0.92; p < 0.001). The Italian version of the CRS-R can be administered reliably and can be also employed to discriminate patients in vegetative and in minimally conscious state.

Evaluation of camouflage pattern performance of textiles by human observers and CAMAELEON

NASA Astrophysics Data System (ADS)

Heinrich, Daniela H.; Selj, Gorm K.

2017-10-01

Military textiles with camouflage pattern are an important part of the protection measures for soldiers. Military operational environments differ a lot depending on climate and vegetation. This requires very different camouflage pattern to achieve good protection. To find the best performing pattern for given environments we have in earlier evaluations mainly applied observer trials as evaluation method. In these camouflage evaluation test human observers were asked to search for targets (in natural settings) presented on a high resolution PC screen, and the corresponding detection times were recorded. Another possibility is to base the evaluation on simulations. CAMAELEON is a licensed tool that ranks camouflaged targets by their similarity with local backgrounds. The similarity is estimated through the parameters local contrast, orientation of structures in the pattern and spatial frequency, by mimicking the response and signal processing in the visual cortex of the human eye. Simulations have a number of advantages over observer trials, for example, that they are more flexible, cheaper, and faster. Applying these two methods to the same images of camouflaged targets we found that CAMAELEON simulation results didn't match observer trial results for targets with disruptive patterns. This finding now calls for follow up studies in order to learn more about the advantages and pitfalls of CAMAELEON. During recent observer trials we studied new camouflage patterns and the effect of additional equipment, such as combat vests. In this paper we will present the results from a study comparing evaluation results of human based observer trials and CAMAELEON.

Ultrasound functional evaluation of fetuses with myelomeningocele: study of the interpretation of results.

PubMed

Maroto, A; Illescas, T; Meléndez, M; Arévalo, S; Rodó, C; Peiró, J L; Belfort, M; Cuxart, A; Carreras, E

2017-10-01

To assess the reliability of the interpretation of a new technique for the ultrasound evaluation of the level of neurological lesion in fetuses with myelomeningocele. Observational study including myelomeningocele fetuses, referred to our center for the sonographic assessment of the fetal lower-limb movements, made and recorded by an expert in Maternal-fetal medicine and a specialist in Rehabilitation. Two observers, with different levels of expertise and blinded to each other's results, interpreted each recorded scan two different times. The agreement for the segmental levels assigned between the observers and the gold standard, the inter-observer and intra-observer reproducibility were tested using the weighed Kappa (wκ) index. Twenty-eight scans were recorded and evaluated. The agreement between the observers and the gold standard remained constant for the expert observer (wκ = 0.82) and increased (wκ = 0.66-wκ = 0.72) for the other one. The inter-observer and the intra-observer variability for the expert observer were wκ = 0.72 and wκ = 0.94, respectively. The agreement for the prenatal evaluation of the segmental neurological level was excellent, after a short training period, for observers with different degrees of expertise. The interpretation of this technique is reproducible enough and this supports its value for the prediction of postnatal motor function in myelomeningocele fetuses.

The Impact of Current and Future Polar Orbiting Satellite Data on Numerical Weather Prediction at NASA/GSFC

NASA Technical Reports Server (NTRS)

Atlas, Robert

2004-01-01

The lack of adequate observational data continues to be recognized as a major factor limiting both atmospheric research and numerical prediction on a variety of temporal and spatial scales. Since the advent of meteorological satellites in the 1960's, a considerable research effort has been directed toward the design of space-borne meteorological sensors, the development of optimal methods for the utilization of these data, (and an assessment of the influence of existing satellite data and the potential influence of future satellite observations on numerical weather prediction. This has included both Observing System Experiments (OSEs) and Observing System Simulation Experiments (OSSEs). OSEs are conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. While OSEs are performed with existing data, OSSEs are conducted to evaluate the potential for future observing systems to improve-NWP, as well as to evaluate trade-offs in observing system design, and to develop and test improved methods for data assimilation. At the conference, results from OSEs to evaluate satellite data sets that have recently become available to the global observing system, such as AIRS and Seawinds, and results from OSSEs to determine the potential impact of space-based lidar winds will be presented.

Understanding USGS user needs and Earth observing data use for decision making

NASA Astrophysics Data System (ADS)

Wu, Z.

2016-12-01

US Geological Survey (USGS) initiated the Requirements, Capabilities and Analysis for Earth Observations (RCA-EO) project in the Land Remote Sensing (LRS) program, collaborating with the National Oceanic and Atmospheric Administration (NOAA) to jointly develop the supporting information infrastructure - The Earth Observation Requirements Evaluation Systems (EORES). RCA-EO enables us to collect information on current data products and projects across the USGS and evaluate the impacts of Earth observation data from all sources, including spaceborne, airborne, and ground-based platforms. EORES allows users to query, filter, and analyze usage and impacts of Earth observation data at different organizational level within the bureau. We engaged over 500 subject matter experts and evaluated more than 1000 different Earth observing data sources and products. RCA-EO provides a comprehensive way to evaluate impacts of Earth observing data on USGS mission areas and programs through the survey of 345 key USGS products and services. We paid special attention to user feedback about Earth observing data to inform decision making on improving user satisfaction. We believe the approach and philosophy of RCA-EO can be applied in much broader scope to derive comprehensive knowledge of Earth observing systems impacts and usage and inform data products development and remote sensing technology innovation.

Evaluating Teacher Preparation Using Graduates' Observational Ratings

ERIC Educational Resources Information Center

Ronfeldt, Matthew; Campbell, Shanyce L.

2016-01-01

Despite growing calls for more accountability of teacher education programs (TEPs), there is little consensus about how to evaluate them. This study investigates the potential for using observational ratings of program completers to evaluate TEPs. Drawing on statewide data on almost 9,500 program completers, representing 44 providers (183…

30 CFR 14.3 - Observers at tests and evaluations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Observers at tests and evaluations. 14.3 Section 14.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS...

Psychological Evaluation of Korean School Children: A Preliminary Report.

ERIC Educational Resources Information Center

Koh, Tong-He; Koh, Soon D.

Observations were made while psychologically evaluating Korean school children in the greater Chicago area. The observations were drawn from work with Korean children who were referred for psychological evaluation because of learning or behavioral/emotional problems. Initial demographic data was taken describing the children's age, length of time…

Validating an Observation Protocol to Measure Special Education Teacher Effectiveness

ERIC Educational Resources Information Center

Johnson, Evelyn S.; Semmelroth, Carrie L.

2015-01-01

This study used Kane's (2013) Interpretation/Use Argument (IUA) to measure validity on the Recognizing Effective Special Education Teachers (RESET) observation tool. The RESET observation tool is designed to evaluate special education teacher effectiveness using evidence-based instructional practices as the basis for evaluation. In alignment with…

Mind the Gap: Accountability, Observation and Special Education

ERIC Educational Resources Information Center

Crowe, Christina C.; Rivers, Susan E.; Bertoli, Michelle C.

2017-01-01

There is an absence of observation-based tools designed to evaluate teaching in special education classrooms. Evaluations derived from classroom observations are integral to the accountability process, adding value to understanding teaching and learning by providing a lens into the classroom that test scores cannot capture. The present paper…

The Pfirrmann classification of lumbar intervertebral disc degeneration: an independent inter- and intra-observer agreement assessment.

PubMed

Urrutia, Julio; Besa, Pablo; Campos, Mauricio; Cikutovic, Pablo; Cabezon, Mario; Molina, Marcelo; Cruz, Juan Pablo

2016-09-01

Grading inter-vertebral disc degeneration (IDD) is important in the evaluation of many degenerative conditions, including patients with low back pain. Magnetic resonance imaging (MRI) is considered the best imaging instrument to evaluate IDD. The Pfirrmann classification is commonly used to grade IDD; the authors describing this classification showed an adequate agreement using it; however, there has been a paucity of independent agreement studies using this grading system. The aim of this study was to perform an independent inter- and intra-observer agreement study using the Pfirrmann classification. T2-weighted sagittal images of 79 patients consecutively studied with lumbar spine MRI were classified using the Pfirrmann grading system by six evaluators (three spine surgeons and three radiologists). After a 6-week interval, the 79 cases were presented to the same evaluators in a random sequence for repeat evaluation. The intra-class correlation coefficient (ICC) and the weighted kappa (wκ) were used to determine the inter- and intra-observer agreement. The inter-observer agreement was excellent, with an ICC = 0.94 (0.93-0.95) and wκ = 0.83 (0.74-0.91). There were no differences between spine surgeons and radiologists. Likewise, there were no differences in agreement evaluating the different lumbar discs. Most differences among observers were only of one grade. Intra-observer agreement was also excellent with ICC = 0.86 (0.83-0.89) and wκ = 0.89 (0.85-0.93). In this independent study, the Pfirrmann classification demonstrated an adequate agreement among different observers and by the same observer on separate occasions. Furthermore, it allows communication between radiologists and spine surgeons.

The development and validation of The Inquiry Science Observation Coding Sheet.

PubMed

Brandon, P R; Taum, A K H; Young, D B; Pottenger, F M

2008-08-01

Evaluation reports increasingly document the degree of program implementation, particularly the extent to which programs adhere to prescribed steps and procedures. Many reports are cursory, however, and few, if any, fully portray the long and winding path taken when developing evaluation instruments, particularly observation instruments. In this article, we describe the development of an observational method for evaluating the degree to which K-12 inquiry science programs are implemented, including the many steps and decisions that occurred during the development, and present evidence for the reliability and validity of the data that we collected with the instrument. The article introduces a method for measuring the adherence of inquiry science implementation and gives evaluators a full picture of what they might expect when developing observation instruments for assessing the degree of program implementation.

Confronting the WRF and RAMS mesoscale models with innovative observations in the Netherlands: Evaluating the boundary layer heat budget

NASA Astrophysics Data System (ADS)

Steeneveld, G. J.; Tolk, L. F.; Moene, A. F.; Hartogensis, O. K.; Peters, W.; Holtslag, A. A. M.

2011-12-01

The Weather Research and Forecasting Model (WRF) and the Regional Atmospheric Mesoscale Model System (RAMS) are frequently used for (regional) weather, climate and air quality studies. This paper covers an evaluation of these models for a windy and calm episode against Cabauw tower observations (Netherlands), with a special focus on the representation of the physical processes in the atmospheric boundary layer (ABL). In addition, area averaged sensible heat flux observations by scintillometry are utilized which enables evaluation of grid scale model fluxes and flux observations at the same horizontal scale. Also, novel ABL height observations by ceilometry and of the near surface longwave radiation divergence are utilized. It appears that WRF in its basic set-up shows satisfactory model results for nearly all atmospheric near surface variables compared to field observations, while RAMS needed refining of its ABL scheme. An important inconsistency was found regarding the ABL daytime heat budget: Both model versions are only able to correctly forecast the ABL thermodynamic structure when the modeled surface sensible heat flux is much larger than both the eddy-covariance and scintillometer observations indicate. In order to clarify this discrepancy, model results for each term of the heat budget equation is evaluated against field observations. Sensitivity studies and evaluation of radiative tendencies and entrainment reveal that possible errors in these variables cannot explain the overestimation of the sensible heat flux within the current model infrastructure.

Automation of immunohistochemical evaluation in breast cancer using image analysis

PubMed Central

Prasad, Keerthana; Tiwari, Avani; Ilanthodi, Sandhya; Prabhu, Gopalakrishna; Pai, Muktha

2011-01-01

AIM: To automate breast cancer diagnosis and to study the inter-observer and intra-observer variations in the manual evaluations. METHODS: Breast tissue specimens from sixty cases were stained separately for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2/neu). All cases were assessed by manual grading as well as image analysis. The manual grading was performed by an experienced expert pathologist. To study inter-observer and intra-observer variations, we obtained readings from another pathologist as the second observer from a different laboratory who has a little less experience than the first observer. We also took a second reading from the second observer to study intra-observer variations. Image analysis was carried out using in-house developed software (TissueQuant). A comparison of the results from image analysis and manual scoring of ER, PR and HER-2/neu was also carried out. RESULTS: The performance of the automated analysis in the case of ER, PR and HER-2/neu expressions was compared with the manual evaluations. The performance of the automated system was found to correlate well with the manual evaluations. The inter-observer variations were measured using Spearman correlation coefficient r and 95% confidence interval. In the case of ER expression, Spearman correlation r = 0.53, in the case of PR expression, r = 0.63, and in the case of HER-2/neu expression, r = 0.68. Similarly, intra-observer variations were also measured. In the case of ER, PR and HER-2/neu expressions, r = 0.46, 0.66 and 0.70, respectively. CONCLUSION: The automation of breast cancer diagnosis from immunohistochemically stained specimens is very useful for providing objective and repeatable evaluations. PMID:21611095

[Evaluation of echocardiographic left ventricular wall motion analysis supported by internet picture viewing system].

PubMed

Hirano, Yutaka; Ikuta, Shin-Ichiro; Nakano, Manabu; Akiyama, Seita; Nakamura, Hajime; Nasu, Masataka; Saito, Futoshi; Nakagawa, Junichi; Matsuzaki, Masashi; Miyazaki, Shunichi

2007-02-01

Assessment of deterioration of regional wall motion by echocardiography is not only subjective but also features difficulties with interobserver agreement. Progress in digital communication technology has made it possible to send video images from a distant location via the Internet. The possibility of evaluating left ventricular wall motion using video images sent via the Internet to distant institutions was evaluated. Twenty-two subjects were randomly selected. Four sets of video images (parasternal long-axis view, parasternal short-axis view, apical four-chamber view, and apical two-chamber view) were taken for one cardiac cycle. The images were sent via the Internet to two institutions (observer C in facility A and observers D and E in facility B) for evaluation. Great care was taken to prevent disclosure of patient information to these observers. Parasternal long-axis images were divided into four segments, and the parasternal short-axis view, apical four-chamber view, and apical two-chamber view were divided into six segments. One of the following assessments, normokinesis, hypokinesis, akinesis, or dyskinesis, was assigned to each segment. The interobserver rates of agreement in judgments between observers C and D, observers C and E, and intraobserver agreement rate (for observer D) were calculated. The rate of interobserver agreement was 85.7% (394/460 segments; Kappa = 0.65) between observers C and D, 76.7% (353/460 segments; Kappa = 0.39) between observers D and E, and 76.3% (351/460 segments; Kappa = 0.36)between observers C and E, and intraobserver agreement was 94.3% (434/460; Kappa = 0.86). Segments of difference judgments between observers C and D were normokinesis-hypokinesis; 62.1%, hypokinesis-akinesis; 33.3%, akinesis-dyskinesis; 3.0%, and normokinesis-akinesis; 1.5%. Wall motion can be evaluated at remote institutions via the Internet.

A framework to observe and evaluate the sustainability of human-natural systems in a complex dynamic context.

PubMed

Satanarachchi, Niranji; Mino, Takashi

2014-01-01

This paper aims to explore the prominent implications of the process of observing complex dynamics linked to sustainability in human-natural systems and to propose a framework for sustainability evaluation by introducing the concept of sustainability boundaries. Arguing that both observing and evaluating sustainability should engage awareness of complex dynamics from the outset, we try to embody this idea in the framework by two complementary methods, namely, the layer view- and dimensional view-based methods, which support the understanding of a reflexive and iterative sustainability process. The framework enables the observation of complex dynamic sustainability contexts, which we call observation metastructures, and enable us to map the contexts to sustainability boundaries.

First On-Site Data Analysis System for Subaru/Suprime-Cam

NASA Astrophysics Data System (ADS)

Furusawa, Hisanori; Okura, Yuki; Mineo, Sogo; Takata, Tadafumi; Nakata, Fumiaki; Tanaka, Manobu; Katayama, Nobuhiko; Itoh, Ryosuke; Yasuda, Naoki; Miyazaki, Satoshi; Komiyama, Yutaka; Utsumi, Yousuke; Uchida, Tomohisa; Aihara, Hiroaki

2011-03-01

We developed an automated on-site quick analysis system for mosaic CCD data of Suprime-Cam, which is a wide-field camera mounted at the prime focus of the Subaru Telescope, Mauna Kea, Hawaii. The first version of the data-analysis system was constructed, and started to operate in general observations. This system is a new function of observing support at the Subaru Telescope to provide the Subaru user community with an automated on-site data evaluation, aiming at improvements of observers' productivity, especially in large imaging surveys. The new system assists the data evaluation tasks in observations by the continuous monitoring of the characteristics of every data frame during observations. The evaluation results and data frames processed by this system are also useful for reducing the data-processing time in a full analysis after an observation. The primary analysis functions implemented in the data-analysis system are composed of automated realtime analysis for data evaluation and on-demand analysis, which is executed upon request, including mosaicing analysis and flat making analysis. In data evaluation, which is controlled by the organizing software, the database keeps track of the analysis histories, as well as the evaluated values of data frames, including seeing and sky background levels; it also helps in the selection of frames for mosaicing and flat making analysis. We examined the system performance and confirmed an improvement in the data-processing time by a factor of 9 with the aid of distributed parallel data processing and on-memory data processing, which makes the automated data evaluation effective.

Evaluation of a hydrological model based on Bidirectional Reach (BReach)

NASA Astrophysics Data System (ADS)

Van Eerdenbrugh, Katrien; Van Hoey, Stijn; Verhoest, Niko E. C.

2016-04-01

Evaluation and discrimination of model structures is crucial to ensure an appropriate use of hydrological models. When evaluating model results by aggregating their quality in (a subset of) individual observations, overall results of this analysis sometimes conceal important detailed information about model structural deficiencies. Analyzing model results within their local (time) context can uncover this detailed information. In this research, a methodology called Bidirectional Reach (BReach) is proposed to evaluate and analyze results of a hydrological model by assessing the maximum left and right reach in each observation point that is used for model evaluation. These maximum reaches express the capability of the model to describe a subset of the evaluation data both in the direction of the previous (left) and of the following data (right). This capability is evaluated on two levels. First, on the level of individual observations, the combination of a parameter set and an observation is classified as non-acceptable if the deviation between the accompanying model result and the measurement exceeds observational uncertainty. Second, the behavior in a sequence of observations is evaluated by means of a tolerance degree. This tolerance degree expresses the condition for satisfactory model behavior in a data series and is defined by the percentage of observations within this series that can have non-acceptable model results. Based on both criteria, the maximum left and right reaches of a model in an observation represent the data points in the direction of the previous respectively the following observations beyond which none of the sampled parameter sets both are satisfactory and result in an acceptable deviation. After assessing these reaches for a variety of tolerance degrees, results can be plotted in a combined BReach plot that show temporal changes in the behavior of model results. The methodology is applied on a Probability Distributed Model (PDM) of the river Grote Nete upstream of Geel-Zammel with 1 106 randomly sampled parameter sets for three separate years. Acceptable model results must fit in the 95 % uncertainty bounds of observed discharges and tolerance degrees of 0 %, 5 %, 10 %, 20 % and 40 % are applied. An evaluation of BReach results with regard to other variables, such as the magnitude and the rate of change of the observed discharges enables to detect recurring patterns in model errors. This results in an augmented understanding of the model's structural deficiencies, revealing the incapability of the PDM model to simulate both high and low flow simulations with a single parameter set for this catchment. As the methodology can be applied for different hydrological model structures, it is a useful tool to gain understanding of the difference in behavior of competing models.

When the third party observer of a neuropsychological evaluation is an audio-recorder.

PubMed

Constantinou, Marios; Ashendorf, Lee; McCaffrey, Robert J

2002-08-01

The presence of third parties during neuropsychological evaluations is an issue of concern for contemporary neuropsychologists. Previous studies have reported that the presence of an observer during neuropsychological testing alters the performance of individuals under evaluation. The present study sought to investigate whether audio-recording affects the neuropsychological test performance of individuals in the same way that third party observation does. In the presence of an audio-recorder the performance of the participants on memory tests declined. Performance on motor tests, on the other hand, was not affected by the presence of an audio-recorder. The implications of these findings in forensic neuropsychological evaluations are discussed.

The evaluation of ASOS for the Kennedy Space Center's Shuttle Landing Facility

NASA Technical Reports Server (NTRS)

Yersavich, Ann; Wheeler, Mark; Taylor, Gregory; Schumann, Robin; Manobianco, John

1994-01-01

This report documents the Applied Meteorology Unit's (AMU) evaluation of the effectiveness and utility of the Automated Surface Observing System (ASOS) in terms of spaceflight operations and user requirements. In particular, the evaluation determines which of the Shuttle Landing Facility (SLF) observation requirements can be satisfied by ASOS. This report also includes a summary of ASOS' background, current configuration and specifications, system performance, and the possible concepts of operations for use of ASOS at the SLF. This evaluation stems from a desire by the Air Force to determine if ASOS units could be used to reduce the cost of SLF meteorological observations.

Making Observation Count: Key Design Elements for Meaningful Teacher Observation. Policy Brief 13-5

ERIC Educational Resources Information Center

Goldstein, Jennifer

2013-01-01

Teacher evaluation has emerged as a potentially powerful policy lever in state and federal debates about how to improve public education. The role of student test scores and "value-added" measures in teacher evaluation has generated intense public controversy, but other approaches to evaluation including especially classroom observations…

Evaluation of New York state's mandatory occupant restraint law. Volume 1, Observational surveys of safety restraint use in New York State

DOT National Transportation Integrated Search

1985-12-01

This is the final report on the results of three observational surveys of restraint use by front seat occupants conducted as part of the evaluation of New York's Mandatory Occupant Restraint Law. Observations were conducted at a probability sample of...

Leveraging Teacher Talent: Peer Observation in Educator Evaluation. Ask the Team

ERIC Educational Resources Information Center

Jacques, Catherine

2013-01-01

Many teachers are already keen observers and skilled in supporting and collaborating with their colleagues. Leveraging this rich talent among staff can be an efficient way to address capacity challenges and enrich teachers' evaluations with more targeted feedback. Teachers, however, require training to become systematic, reliable observers who can…

14 CFR 135.76 - DOD Commercial Air Carrier Evaluator's Credentials: Admission to pilots compartment: Forward...

Code of Federal Regulations, 2011 CFR

2011-01-01

... Credentials: Admission to pilots compartment: Forward observer's seat. 135.76 Section 135.76 Aeronautics and... Commercial Air Carrier Evaluator's Credentials: Admission to pilots compartment: Forward observer's seat. (a.... (b) A forward observer's seat on the flight deck or forward passenger seat with headset or speaker...

14 CFR 135.76 - DOD Commercial Air Carrier Evaluator's Credentials: Admission to pilots compartment: Forward...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Credentials: Admission to pilots compartment: Forward observer's seat. 135.76 Section 135.76 Aeronautics and... Commercial Air Carrier Evaluator's Credentials: Admission to pilots compartment: Forward observer's seat. (a.... (b) A forward observer's seat on the flight deck or forward passenger seat with headset or speaker...

Examining Teacher Effectiveness Using Classroom Observation Scores: Evidence from the Randomization of Teachers to Students

ERIC Educational Resources Information Center

Garrett, Rachel; Steinberg, Matthew P.

2015-01-01

Despite policy efforts to encourage multiple measures of performance in newly developing teacher evaluation systems, practical constraints often result in evaluations based predominantly on formal classroom observations. Yet there is limited knowledge of how these observational measures relate to student achievement. This article leverages the…

Is Beauty in the Eyes of the Beholder? Aesthetic Quality versus Technical Skill in Movement Evaluation of Tai Chi.

PubMed

Zamparo, Paola; Zorzi, Elena; Marcantoni, Sara; Cesari, Paola

2015-01-01

The aim of this study was to compare experts to naïve practitioners in rating the beauty and the technical quality of a Tai Chi sequence observed in video-clips (of high and middle level performances). Our hypothesis are: i) movement evaluation will correlate with the level of skill expressed in the kinematics of the observed action but ii) only experts will be able to unravel the technical component from the aesthetic component of the observed action. The judgments delivered indicate that both expert and non-expert observers are able to discern a good from a mediocre performance; however, as expected, only experts discriminate the technical from the aesthetic component of the action evaluated and do this independently of the level of skill shown by the model (high or middle level performances). Furthermore, the judgments delivered were strongly related to the kinematic variables measured in the observed model, indicating that observers rely on specific movement kinematics (e.g. movement amplitude, jerk and duration) for action evaluation. These results provide evidence of the complementary functional role of visual and motor action representation in movement evaluation and underline the role of expertise in judging the aesthetic quality of movements.

Is Beauty in the Eyes of the Beholder? Aesthetic Quality versus Technical Skill in Movement Evaluation of Tai Chi

PubMed Central

2015-01-01

The aim of this study was to compare experts to naïve practitioners in rating the beauty and the technical quality of a Tai Chi sequence observed in video-clips (of high and middle level performances). Our hypothesis are: i) movement evaluation will correlate with the level of skill expressed in the kinematics of the observed action but ii) only experts will be able to unravel the technical component from the aesthetic component of the observed action. The judgments delivered indicate that both expert and non-expert observers are able to discern a good from a mediocre performance; however, as expected, only experts discriminate the technical from the aesthetic component of the action evaluated and do this independently of the level of skill shown by the model (high or middle level performances). Furthermore, the judgments delivered were strongly related to the kinematic variables measured in the observed model, indicating that observers rely on specific movement kinematics (e.g. movement amplitude, jerk and duration) for action evaluation. These results provide evidence of the complementary functional role of visual and motor action representation in movement evaluation and underline the role of expertise in judging the aesthetic quality of movements. PMID:26047473

Evaluation of Aerosol-cloud Interaction in the GISS Model E Using ARM Observations

NASA Technical Reports Server (NTRS)

DeBoer, G.; Bauer, S. E.; Toto, T.; Menon, Surabi; Vogelmann, A. M.

2013-01-01

Observations from the US Department of Energy's Atmospheric Radiation Measurement (ARM) program are used to evaluate the ability of the NASA GISS ModelE global climate model in reproducing observed interactions between aerosols and clouds. Included in the evaluation are comparisons of basic meteorology and aerosol properties, droplet activation, effective radius parameterizations, and surface-based evaluations of aerosol-cloud interactions (ACI). Differences between the simulated and observed ACI are generally large, but these differences may result partially from vertical distribution of aerosol in the model, rather than the representation of physical processes governing the interactions between aerosols and clouds. Compared to the current observations, the ModelE often features elevated droplet concentrations for a given aerosol concentration, indicating that the activation parameterizations used may be too aggressive. Additionally, parameterizations for effective radius commonly used in models were tested using ARM observations, and there was no clear superior parameterization for the cases reviewed here. This lack of consensus is demonstrated to result in potentially large, statistically significant differences to surface radiative budgets, should one parameterization be chosen over another.

Observing System Forecast Experiments at the DAO

NASA Technical Reports Server (NTRS)

Atlas, Robert

2001-01-01

Since the advent of meteorological satellites in the 1960's, numerous experiments have been conducted in order to evaluate the impact of these and other data on atmospheric analysis and prediction. Such studies have included both OSE'S and OSSE's. The OSE's were conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. Such experiments have been performed for selected types of conventional data and for various satellite data sets as they became available. (See for example the 1989 ECMWF/EUMETSAT workshop proceedings on "The use of satellite data in operational numerical weather prediction" and the references contained therein.) The ODYSSEY were conducted to evaluate the potential for future observing systems to improve Numerical Weather Prediction NWP and to plan for the Global Weather Experiment and more recently for EVANS (Atlas et al., 1985a; Arnold and Day, 1986; Hoffman et al., 1990). In addition, OSSE's have been run to evaluate trade-offs in the design of observing systems and observing networks (Atlas and Emmitt, 1991; Rohaly and Krishnamurti, 1993), and to test new methodology for data assimilation (Atlas and Bloom, 1989).

Balancing the Role of Priors in Multi-Observer Segmentation Evaluation

PubMed Central

Huang, Xiaolei; Wang, Wei; Lopresti, Daniel; Long, Rodney; Antani, Sameer; Xue, Zhiyun; Thoma, George

2009-01-01

Comparison of a group of multiple observer segmentations is known to be a challenging problem. A good segmentation evaluation method would allow different segmentations not only to be compared, but to be combined to generate a “true” segmentation with higher consensus. Numerous multi-observer segmentation evaluation approaches have been proposed in the literature, and STAPLE in particular probabilistically estimates the true segmentation by optimal combination of observed segmentations and a prior model of the truth. An Expectation–Maximization (EM) algorithm, STAPLE’S convergence to the desired local minima depends on good initializations for the truth prior and the observer-performance prior. However, accurate modeling of the initial truth prior is nontrivial. Moreover, among the two priors, the truth prior always dominates so that in certain scenarios when meaningful observer-performance priors are available, STAPLE can not take advantage of that information. In this paper, we propose a Bayesian decision formulation of the problem that permits the two types of prior knowledge to be integrated in a complementary manner in four cases with differing application purposes: (1) with known truth prior; (2) with observer prior; (3) with neither truth prior nor observer prior; and (4) with both truth prior and observer prior. The third and fourth cases are not discussed (or effectively ignored) by STAPLE, and in our research we propose a new method to combine multiple-observer segmentations based on the maximum a posterior (MAP) principle, which respects the observer prior regardless of the availability of the truth prior. Based on the four scenarios, we have developed a web-based software application that implements the flexible segmentation evaluation framework for digitized uterine cervix images. Experiment results show that our framework has flexibility in effectively integrating different priors for multi-observer segmentation evaluation and it also generates results comparing favorably to those by the STAPLE algorithm and the Majority Vote Rule. PMID:20523759

Observational uncertainty and regional climate model evaluation: A pan-European perspective

NASA Astrophysics Data System (ADS)

Kotlarski, Sven; Szabó, Péter; Herrera, Sixto; Räty, Olle; Keuler, Klaus; Soares, Pedro M.; Cardoso, Rita M.; Bosshard, Thomas; Pagé, Christian; Boberg, Fredrik; Gutiérrez, José M.; Jaczewski, Adam; Kreienkamp, Frank; Liniger, Mark. A.; Lussana, Cristian; Szepszo, Gabriella

2017-04-01

Local and regional climate change assessments based on downscaling methods crucially depend on the existence of accurate and reliable observational reference data. In dynamical downscaling via regional climate models (RCMs) observational data can influence model development itself and, later on, model evaluation, parameter calibration and added value assessment. In empirical-statistical downscaling, observations serve as predictand data and directly influence model calibration with corresponding effects on downscaled climate change projections. Focusing on the evaluation of RCMs, we here analyze the influence of uncertainties in observational reference data on evaluation results in a well-defined performance assessment framework and on a European scale. For this purpose we employ three different gridded observational reference grids, namely (1) the well-established EOBS dataset (2) the recently developed EURO4M-MESAN regional re-analysis, and (3) several national high-resolution and quality-controlled gridded datasets that recently became available. In terms of climate models five reanalysis-driven experiments carried out by five different RCMs within the EURO-CORDEX framework are used. Two variables (temperature and precipitation) and a range of evaluation metrics that reflect different aspects of RCM performance are considered. We furthermore include an illustrative model ranking exercise and relate observational spread to RCM spread. The results obtained indicate a varying influence of observational uncertainty on model evaluation depending on the variable, the season, the region and the specific performance metric considered. Over most parts of the continent, the influence of the choice of the reference dataset for temperature is rather small for seasonal mean values and inter-annual variability. Here, model uncertainty (as measured by the spread between the five RCM simulations considered) is typically much larger than reference data uncertainty. For parameters of the daily temperature distribution and for the spatial pattern correlation, however, important dependencies on the reference dataset can arise. The related evaluation uncertainties can be as large or even larger than model uncertainty. For precipitation the influence of observational uncertainty is, in general, larger than for temperature. It often dominates model uncertainty especially for the evaluation of the wet day frequency, the spatial correlation and the shape and location of the distribution of daily values. But even the evaluation of large-scale seasonal mean values can be considerably affected by the choice of the reference. When employing a simple and illustrative model ranking scheme on these results it is found that RCM ranking in many cases depends on the reference dataset employed.

Development of a Peer Teaching-Assessment Program and a Peer Observation and Evaluation Tool

PubMed Central

Trujillo, Jennifer M.; Barr, Judith; Gonyeau, Michael; Van Amburgh, Jenny A.; Matthews, S. James; Qualters, Donna

2008-01-01

Objectives To develop a formalized, comprehensive, peer-driven teaching assessment program and a valid and reliable assessment tool. Methods A volunteer taskforce was formed and a peer-assessment program was developed using a multistep, sequential approach and the Peer Observation and Evaluation Tool (POET). A pilot study was conducted to evaluate the efficiency and practicality of the process and to establish interrater reliability of the tool. Intra-class correlation coefficients (ICC) were calculated. Results ICCs for 8 separate lectures evaluated by 2-3 observers ranged from 0.66 to 0.97, indicating good interrater reliability of the tool. Conclusion Our peer assessment program for large classroom teaching, which includes a valid and reliable evaluation tool, is comprehensive, feasible, and can be adopted by other schools of pharmacy. PMID:19325963

Evaluation of decadal predictions using a satellite simulator for the Special Sensor Microwave Imager (SSM/I)

NASA Astrophysics Data System (ADS)

Spangehl, Thomas; Schröder, Marc; Bodas-Salcedo, Alejandro; Glowienka-Hense, Rita; Hense, Andreas; Hollmann, Rainer; Dietzsch, Felix

2017-04-01

Decadal climate predictions are commonly evaluated focusing on geophysical parameters such as temperature, precipitation or wind speed using observational datasets and reanalysis. Alternatively, satellite based radiance measurements combined with satellite simulator techniques to deduce virtual satellite observations from the numerical model simulations can be used. The latter approach enables an evaluation in the instrument's parameter space and has the potential to reduce uncertainties on the reference side. Here we present evaluation methods focusing on forward operator techniques for the Special Sensor Microwave Imager (SSM/I). The simulator is developed as an integrated part of the CFMIP Observation Simulator Package (COSP). On the observational side the SSM/I and SSMIS Fundamental Climate Data Record (FCDR) released by CM SAF (http://dx.doi.org/10.5676/EUM_SAF_CM/FCDR_MWI/V002) is used, which provides brightness temperatures for different channels and covers the period from 1987 to 2013. The simulator is applied to hindcast simulations performed within the MiKlip project (http://fona-miklip.de) which is funded by the BMBF (Federal Ministry of Education and Research in Germany). Probabilistic evaluation results are shown based on a subset of the hindcast simulations covering the observational period.

Evaluation of a Multi-Decadal Simulation of Stratospheric Ozone by Comparison with Total Ozone Mapping Spectrometer (TOMS) Observations

NASA Technical Reports Server (NTRS)

Douglass, Anne R.; Stolarski, Richard S.; Steenrod, Steven; Pawson, Steven

2003-01-01

One key application of atmospheric chemistry and transport models is prediction of the response of ozone and other constituents to various natural and anthropogenic perturbations. These include changes in composition, such as the previous rise and recent decline in emission of man-made chlorofluorcarbons, changes in aerosol loading due to volcanic eruption, and changes in solar forcing. Comparisons of hindcast model results for the past few decades with observations are a key element of model evaluation and provide a sense of the reliability of model predictions. The 25 year data set from Total Ozone Mapping Spectrometers is a cornerstone of such model evaluation. Here we report evaluation of three-dimensional multi-decadal simulation of stratospheric composition. Meteorological fields for this off-line calculation are taken from a 50 year simulation of a general circulation model. Model fields are compared with observations from TOMS and also with observations from the Stratospheric Aerosol and Gas Experiment (SAGE), Microwave Limb Sounder (MLS), Cryogenic Limb Array Etalon Spectrometer (CLAES), and the Halogen Occultation Experiment (HALOE). This overall evaluation will emphasize the spatial, seasonal, and interannual variability of the simulation compared with observed atmospheric variability.

Peer Observation Reports and Student Evaluations of Teaching: Who Are the Experts?

ERIC Educational Resources Information Center

Ackerman, David; Gross, Barbara L.; Vigneron, Franck

2009-01-01

This study is an exploratory inquiry into the perceptions of university faculty regarding two forms of teaching evaluations, student evaluations of teaching (SET), and peer observation reports (POR). Which, if either, better assesses the quality of instruction? Who are the real experts in judging teaching quality: peers who are experts in their…

Learning from Teacher Observations: Challenges and Opportunities Posed by New Teacher Evaluation Systems

ERIC Educational Resources Information Center

Hill, Heather C.; Grossman, Pam

2013-01-01

In this article, Heather C. Hill and Pam Grossman discuss the current focus on using teacher observation instruments as part of new teacher evaluation systems being considered and implemented by states and districts. They argue that if these teacher observation instruments are to achieve the goal of supporting teachers in improving instructional…

Impact of a Checklist on Principal-Teacher Feedback Conferences Following Classroom Observations. REL 2018-285

ERIC Educational Resources Information Center

Mihaly, Kata; Schwartz, Heather L.; Opper, Isaac M.; Grimm, Geoffrey; Rodriguez, Luis; Mariano, Louis T.

2018-01-01

Most states' teacher evaluation systems have changed substantially in the past decade. New evaluation systems typically require school leaders to observe teachers' classrooms two to three times a school year instead of once (Doherty & Jacobs, 2015). The feedback that school leaders provide to teachers after these observations is a key but…

The genes and enzymes for the catabolism of galactitol, D-tagatose, and related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria display convergent evolution.

PubMed

Shakeri-Garakani, A; Brinkkötter, A; Schmid, K; Turgut, S; Lengeler, J W

2004-07-01

Enteric bacteria (Enteriobacteriaceae) carry on their single chromosome about 4000 genes that all strains have in common (referred to here as "obligatory genes"), and up to 1300 "facultative" genes that vary from strain to strain and from species to species. In closely related species, obligatory and facultative genes are orthologous genes that are found at similar loci. We have analyzed a set of facultative genes involved in the degradation of the carbohydrates galactitol, D-tagatose, D-galactosamine and N-acetyl-galactosamine in various pathogenic and non-pathogenic strains of these bacteria. The four carbohydrates are transported into the cell by phosphotransferase (PTS) uptake systems, and are metabolized by closely related or even identical catabolic enzymes via pathways that share several intermediates. In about 60% of Escherichia coli strains the genes for galactitol degradation map to a gat operon at 46.8 min. In strains of Salmonella enterica, Klebsiella pneumoniae and K. oxytoca, the corresponding gat genes, although orthologous to their E. coli counterparts, are found at 70.7 min, clustered in a regulon together with three tag genes for the degradation of D-tagatose, an isomer of D-fructose. In contrast, in all the E. coli strains tested, this chromosomal site was found to be occupied by an aga/kba gene cluster for the degradation of D-galactosamine and N-acetyl-galactosamine. The aga/kba and the tag genes were paralogous either to the gat cluster or to the fru genes for degradation of D-fructose. Finally, in more then 90% of strains of both Klebsiella species, and in about 5% of the E. coli strains, two operons were found at 46.8 min that comprise paralogous genes for catabolism of the isomers D-arabinitol (genes atl or dal) and ribitol (genes rtl or rbt). In these strains gat genes were invariably absent from this location, and they were totally absent in S. enterica. These results strongly indicate that these various gene clusters and metabolic pathways have been subject to convergent evolution among the Enterobacteriaceae. This apparently involved recent horizontal gene transfer and recombination events, as indicated by major chromosomal rearrangements found in their immediate vicinity.

Online Studies on Variation in Orthopedic Surgery: Computed Tomography in MPEG4 Versus DICOM Format.

PubMed

Mellema, Jos J; Mallee, Wouter H; Guitton, Thierry G; van Dijk, C Niek; Ring, David; Doornberg, Job N

2017-10-01

The purpose of this study was to compare the observer participation and satisfaction as well as interobserver reliability between two online platforms, Science of Variation Group (SOVG) and Traumaplatform Study Collaborative, for the evaluation of complex tibial plateau fractures using computed tomography in MPEG4 and DICOM format. A total of 143 observers started with the online evaluation of 15 complex tibial plateau fractures via either the SOVG or Traumaplatform Study Collaborative websites using MPEG4 videos or a DICOM viewer, respectively. Observers were asked to indicate the absence or presence of four tibial plateau fracture characteristics and to rate their satisfaction with the evaluation as provided by the respective online platforms. The observer participation rate was significantly higher in the SOVG (MPEG4 video) group compared to that in the Traumaplatform Study Collaborative (DICOM viewer) group (75 and 43%, respectively; P < 0.001). The median observer satisfaction with the online evaluation was seven (range, 0-10) using MPEG4 video compared to six (range, 1-9) using DICOM viewer (P = 0.11). The interobserver reliability for recognition of fracture characteristics in complex tibial plateau fractures was higher for the evaluation using MPEG4 video. In conclusion, observer participation and interobserver reliability for the characterization of tibial plateau fractures was greater with MPEG4 videos than with a standard DICOM viewer, while there was no difference in observer satisfaction. Future reliability studies should account for the method of delivering images.

Measuring symptoms and functioning of youth with ADHD in middle schools.

PubMed

Evans, Steven W; Allen, Jessica; Moore, Sheryle; Strauss, Victoria

2005-12-01

The identification of reliable and valid means for evaluating the effectiveness of school-based treatments and completing diagnostic evaluations of middle school aged students are needed. The present study examined the inter-rater agreement of teacher ratings and the relationship between ratings and observational data in a middle school setting. The data are interpreted in the context of differences between a secondary and elementary school setting. Teacher ratings and observational data were collected regularly over the course of two academic years for middle school students diagnosed with ADHD. The results indicate low rates of inter-rater agreement as well as low rates of agreement between teachers and observational data, and between observational data collected in different classrooms. Inter-rater agreement was lowest in late fall and gradually increased over the second half of the year. Implications for conducting treatment outcome evaluations of school-based treatment programs and diagnostic evaluations are discussed.

Developing the Fourth Evaluation Dimension: A Protocol for Evaluation of Video From the Patient's Perspective During Major Incident Exercises.

PubMed

Haverkort, J J Mark; Leenen, Luke P H

2017-10-01

Presently used evaluation techniques rely on 3 traditional dimensions: reports from observers, registration system data, and observational cameras. Some of these techniques are observer-dependent and are not reproducible for a second review. This proof-of-concept study aimed to test the feasibility of extending evaluation to a fourth dimension, the patient's perspective. Footage was obtained during a large, full-scale hospital trauma drill. Two mock victims were equipped with point-of-view cameras filming from the patient's head. Based on the Major Incident Hospital's first experience during the drill, a protocol was developed for a prospective, standardized method to evaluate a hospital's major incident response from the patient's perspective. The protocol was then tested in a second drill for its feasibility. New insights were gained after review of the footage. The traditional observer missed some of the evaluation points, which were seen on the point-of-view cameras. The information gained from the patient's perspective proved to be implementable into the designed protocol. Use of point-of-view camera recordings from a mock patient's perspective is a valuable addition to traditional evaluation of trauma drills and trauma care. Protocols should be designed to optimize and objectify judgement of such footage. (Disaster Med Public Health Preparedness. 2017;11:594-599).

Evaluation of the Race/Human Relations Program: Observations--A Second Year's Look at Racial Mixing and Quality of Interactions at School Sites. Evaluation Department Report No. 370.

ERIC Educational Resources Information Center

Stein, Robert Christopher

The evaluation of long-range goals of the Race/Human Relations Program of the San Diego City Schools consisted of observations to determine the degree to which racial mixing was occurring at school sites and the quality of interactions among students and adults. Fifty district employees were trained in the use of the Contextual Evaluation Form. A…

Evaluation of medical management during a mass casualty incident exercise: an objective assessment tool to enhance direct observation.

PubMed

Ingrassia, Pier Luigi; Prato, Federico; Geddo, Alessandro; Colombo, Davide; Tengattini, Marco; Calligaro, Sara; La Mura, Fabrizio; Franc, Jeffrey Michael; Della Corte, Francesco

2010-11-01

Functional exercises represent an important link between disaster planning and disaster response. Although these exercises are widely performed, no standardized method exists for their evaluation. To describe a simple and objective method to assess medical performance during functional exercise events. An evaluation tool comprising three data fields (triage, clinical maneuvers, and radio usage), accompanied by direct anecdotal observational methods, was used to evaluate a large functional mass casualty incident exercise. Seventeen medical responders managed 112 victims of a simulated building explosion. Although 81% of the patients were assigned the appropriate triage codes, evacuation from the site did not follow in priority. Required maneuvers were performed correctly in 85.2% of airway maneuvers and 78.7% of breathing maneuvers, however, significant under-treatment occurred, possibly due to equipment shortages. Extensive use of radio communication was documented. In evaluating this tool, the structured markers were informative, but further information provided by direct observation was invaluable. A three-part tool (triage, medical maneuvers, and radio usage) can provide a method to evaluate functional mass casualty incident exercises, and is easily implemented. For the best results, it should be used in conjunction with direct observation. The evaluation tool has great potential as a reproducible and internationally recognized tool for evaluating disaster management exercises. Copyright © 2010 Elsevier Inc. All rights reserved.

Clinical Observed Performance Evaluation: A Prospective Study in Final Year Students of Surgery

ERIC Educational Resources Information Center

Markey, G. C.; Browne, K.; Hunter, K.; Hill, A. D.

2011-01-01

We report a prospective study of clinical observed performance evaluation (COPE) for 197 medical students in the pre-qualification year of clinical education. Psychometric quality was the main endpoint. Students were assessed in groups of 5 in 40-min patient encounters, with each student the focus of evaluation for 8 min. Each student had a series…

An Observational Study for Evaluating the Effects of Interpersonal Problem-Solving Skills Training on Behavioural Dimensions

ERIC Educational Resources Information Center

Anliak, Sakire; Sahin, Derya

2010-01-01

The present observational study was designed to evaluate the effectiveness of the I Can Problem Solve (ICPS) programme on behavioural change from aggression to pro-social behaviours by using the DECB rating scale. Non-participant observation method was used to collect data in pretest-training-posttest design. It was hypothesised that the ICPS…

Evaluation of Two Methods for Modeling Measurement Errors When Testing Interaction Effects with Observed Composite Scores

ERIC Educational Resources Information Center

Hsiao, Yu-Yu; Kwok, Oi-Man; Lai, Mark H. C.

2018-01-01

Path models with observed composites based on multiple items (e.g., mean or sum score of the items) are commonly used to test interaction effects. Under this practice, researchers generally assume that the observed composites are measured without errors. In this study, we reviewed and evaluated two alternative methods within the structural…

A Regional Climate Model Evaluation System based on contemporary Satellite and other Observations for Assessing Regional Climate Model Fidelity

NASA Astrophysics Data System (ADS)

Waliser, D. E.; Kim, J.; Mattman, C.; Goodale, C.; Hart, A.; Zimdars, P.; Lean, P.

2011-12-01

Evaluation of climate models against observations is an essential part of assessing the impact of climate variations and change on regionally important sectors and improving climate models. Regional climate models (RCMs) are of a particular concern. RCMs provide fine-scale climate needed by the assessment community via downscaling global climate model projections such as those contributing to the Coupled Model Intercomparison Project (CMIP) that form one aspect of the quantitative basis of the IPCC Assessment Reports. The lack of reliable fine-resolution observational data and formal tools and metrics has represented a challenge in evaluating RCMs. Recent satellite observations are particularly useful as they provide a wealth of information and constraints on many different processes within the climate system. Due to their large volume and the difficulties associated with accessing and using contemporary observations, however, these datasets have been generally underutilized in model evaluation studies. Recognizing this problem, NASA JPL and UCLA have developed the Regional Climate Model Evaluation System (RCMES) to help make satellite observations, in conjunction with in-situ and reanalysis datasets, more readily accessible to the regional modeling community. The system includes a central database (Regional Climate Model Evaluation Database: RCMED) to store multiple datasets in a common format and codes for calculating and plotting statistical metrics to assess model performance (Regional Climate Model Evaluation Tool: RCMET). This allows the time taken to compare model data with satellite observations to be reduced from weeks to days. RCMES is a component of the recent ExArch project, an international effort for facilitating the archive and access of massive amounts data for users using cloud-based infrastructure, in this case as applied to the study of climate and climate change. This presentation will describe RCMES and demonstrate its utility using examples from RCMs applied to the southwest US as well as to Africa based on output from the CORDEX activity. Application of RCMES to the evaluation of multi-RCM hindcast for CORDEX-Africa will be presented in a companion paper in A41.

A Regional Climate Model Evaluation System based on Satellite and other Observations

NASA Astrophysics Data System (ADS)

Lean, P.; Kim, J.; Waliser, D. E.; Hall, A. D.; Mattmann, C. A.; Granger, S. L.; Case, K.; Goodale, C.; Hart, A.; Zimdars, P.; Guan, B.; Molotch, N. P.; Kaki, S.

2010-12-01

Regional climate models are a fundamental tool needed for downscaling global climate simulations and projections, such as those contributing to the Coupled Model Intercomparison Projects (CMIPs) that form the basis of the IPCC Assessment Reports. The regional modeling process provides the means to accommodate higher resolution and a greater complexity of Earth System processes. Evaluation of both the global and regional climate models against observations is essential to identify model weaknesses and to direct future model development efforts focused on reducing the uncertainty associated with climate projections. However, the lack of reliable observational data and the lack of formal tools are among the serious limitations to addressing these objectives. Recent satellite observations are particularly useful as they provide a wealth of information on many different aspects of the climate system, but due to their large volume and the difficulties associated with accessing and using the data, these datasets have been generally underutilized in model evaluation studies. Recognizing this problem, NASA JPL / UCLA is developing a model evaluation system to help make satellite observations, in conjunction with in-situ, assimilated, and reanalysis datasets, more readily accessible to the modeling community. The system includes a central database to store multiple datasets in a common format and codes for calculating predefined statistical metrics to assess model performance. This allows the time taken to compare model simulations with satellite observations to be reduced from weeks to days. Early results from the use this new model evaluation system for evaluating regional climate simulations over California/western US regions will be presented.

Evaluating performance of risk identification methods through a large-scale simulation of observational data.

PubMed

Ryan, Patrick B; Schuemie, Martijn J

2013-10-01

There has been only limited evaluation of statistical methods for identifying safety risks of drug exposure in observational healthcare data. Simulations can support empirical evaluation, but have not been shown to adequately model the real-world phenomena that challenge observational analyses. To design and evaluate a probabilistic framework (OSIM2) for generating simulated observational healthcare data, and to use this data for evaluating the performance of methods in identifying associations between drug exposure and health outcomes of interest. Seven observational designs, including case-control, cohort, self-controlled case series, and self-controlled cohort design were applied to 399 drug-outcome scenarios in 6 simulated datasets with no effect and injected relative risks of 1.25, 1.5, 2, 4, and 10, respectively. Longitudinal data for 10 million simulated patients were generated using a model derived from an administrative claims database, with associated demographics, periods of drug exposure derived from pharmacy dispensings, and medical conditions derived from diagnoses on medical claims. Simulation validation was performed through descriptive comparison with real source data. Method performance was evaluated using Area Under ROC Curve (AUC), bias, and mean squared error. OSIM2 replicates prevalence and types of confounding observed in real claims data. When simulated data are injected with relative risks (RR) ≥ 2, all designs have good predictive accuracy (AUC > 0.90), but when RR < 2, no methods achieve 100 % predictions. Each method exhibits a different bias profile, which changes with the effect size. OSIM2 can support methodological research. Results from simulation suggest method operating characteristics are far from nominal properties.

Evaluation of bone marrow aspirates in patients with acute myeloid leukemia at day 14 of induction therapy.

PubMed

Souto Filho, João Tadeu D; Loureiro, Monique M; Pulcheri, Wolmar; Morais, José Carlos; Nucci, Marcio; Portugal, Rodrigo D

2015-07-25

Early assessment of response to chemotherapy in acute myeloid leukemia may be performed by examining bone marrow aspirate (BMA) or biopsy (BMB); a hypocellular bone marrow sample indicates adequate anti-leukemic activity. We sought to evaluate the quantitative and qualitative assessment of BMA performed on day 14 (D14) of chemotherapy, to verify the inter-observer agreement, to compare the results of BMA and BMB, and to evaluate the impact of D14 blast clearance on the overall survival (OS). A total of 107 patients who received standard induction chemotherapy and had bone marrow samples were included. BMA evaluation was performed by two observers using two methods: quantitative assessment and a qualitative (Likert) scale. ROC curves were obtained correlating the BMA quantification of blasts and the qualitative scale, by both observers, with BMB result as gold-standard. There was a significant agreement between the two observers in both the qualitative and quantitative assessments (Kw = 0.737, p < 0.001, and rs = 0.798, p < 0.001; ICC = 0.836, p < 0.001, respectively). The areas under the curve (AUC) were 0.924 and 0.946 for observer 1 and 0.867 and 0.870 for observer 2 for assessments of the percentage of blasts and qualitative scale, respectively. The best cutoff for blast percentage in BMA was 6% and 7% for observers 1 and 2, respectively. A similar analysis for the qualitative scale showed the best cutoff as "probably infiltrated". Patients who attained higher grades of cytoreduction on D14 had better OS. Evaluation of D14 BMA using both methods had a significant agreement with BMB and between observers, identifying a population of patients with poor outcome.

The OSSE Framework at the NASA Global Modeling and Assimilation Office (GMAO)

NASA Astrophysics Data System (ADS)

Moradi, I.; Prive, N.; McCarty, W.; Errico, R. M.; Gelaro, R.

2017-12-01

This abstract summarizes the OSSE framework developed at the Global Modeling and Assimilation Office at the National Aeronautics and Space Administration (NASA/GMAO). Some of the OSSE techniques developed at GMAO including simulation of realistic observations, e.g., adding errors to simulated observations, are now widely used by the community to evaluate the impact of new observations on the weather forecasts. This talk presents some of the recent progresses and challenges in simulating realistic observations, radiative transfer modeling support for the GMAO OSSE activities, assimilation of OSSE observations into data assimilation systems, and evaluating the impact of simulated observations on the forecast skills.

The OSSE Framework at the NASA Global Modeling and Assimilation Office (GMAO)

NASA Technical Reports Server (NTRS)

Moradi, Isaac; Prive, Nikki; McCarty, Will; Errico, Ronald M.; Gelaro, Ron

2017-01-01

This abstract summarizes the OSSE framework developed at the Global Modeling and Assimilation Office at the National Aeronautics and Space Administration (NASA/GMAO). Some of the OSSE techniques developed at GMAO including simulation of realistic observations, e.g., adding errors to simulated observations, are now widely used by the community to evaluate the impact of new observations on the weather forecasts. This talk presents some of the recent progresses and challenges in simulating realistic observations, radiative transfer modeling support for the GMAO OSSE activities, assimilation of OSSE observations into data assimilation systems, and evaluating the impact of simulated observations on the forecast skills.

The homicidol effect: investigating murder as a fitness signal.

PubMed

Dahlén, Micael; Söderlund, Magnus

2012-01-01

This article extends homicide adaptation theory by investigating signal effects of a murder. In two experiments (N = 299 and N = 161) participants reported their perceptions of a described person. The first study manipulated the information about the person (including or excluding a single sentence stating that the person has committed a murder) and stimulus person/observer sex match (same vs. opposite sex). Results suggest that murder functions as a signal of the described person's fitness that enhances observers' evaluations and inclination to interact with the person. Opposite-sex observers evaluate the murderer's intent more favorably than same-sex observers, but these evaluations of intent produce differential (positive vs. negative) effects between the two groups. The second study replicated the findings and ruled out potential confounds.

Exploring Instructional Coaches' Attitudes and Use of the DataCapture Mobile Application to Collect Video-Based Evidence in Teacher Evaluation

ERIC Educational Resources Information Center

Shewell, Justin Reed

2013-01-01

An integral part of teacher development are teacher observations. Many teachers are observed once or twice a year to evaluate their performance and hold them accountable for meeting standards. Instructional coaches, however, observe and work with teachers to help them reflect on their performance, with the goal of improving their practice.…

On Trust Evaluation in Mobile Ad Hoc Networks

NASA Astrophysics Data System (ADS)

Nguyen, Dang Quan; Lamont, Louise; Mason, Peter C.

Trust has been considered as a social relationship between two individuals in human society. But, as computer science and networking have succeeded in using computers to automate many tasks, the concept of trust can be generalized to cover the reliability and relationships of non-human interaction, such as, for example, information gathering and data routing. This paper investigates the evaluation of trust in the context of ad hoc networks. Nodes evaluate each other’s behaviour based on observables. A node then decides whether to trust another node to have certain innate abilities. We show how accurate such an evaluation could be. We also provide the minimum number of observations required to obtain an accurate evaluation, a result that indicates that observation-based trust in ad hoc networks will remain a challenging problem. The impact of making networking decisions using trust evaluation on the network connectivity is also examined. In this manner, quantitative decisions can be made concerning trust-based routing with the knowledge of the potential impact on connectivity.

Improving college science teaching through peer coaching and classroom assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sode, J.R.

Peer coaching involves the observation of one teacher by another. This observation is accompanied by open and honest reflective discussion. The three main components of peer coaching are pre conference (for setting observation guidelines and building trust), observation (the sytematic collection of classroom data), and post conference (a non evaluative examination and discussion of the classroom). The non-evaluative post conference involves an examination of the teaching/learning process that occurred during the observation phase. In effective assessment, information on what and how well students are learning is used to make decisions about overall program improvement and to implement continuous classroom improvement.more » During peer coaching and assessment neither the instructor nor the students are formally evaluated. This session presents a sequential process in which the peer coaching steps of pre conference, observation, and post conference are combined with assessment to provide instructional guidance. An actual cast study, using the student complaint, {open_quotes}Lectures are boring and useless,{close_quotes} is used to demonstrate the process.« less

Intra-observer reproducibility and diagnostic performance of breast shear-wave elastography in Asian women.

PubMed

Park, Hye Young; Han, Kyung Hwa; Yoon, Jung Hyun; Moon, Hee Jung; Kim, Min Jung; Kim, Eun-Kyung

2014-06-01

Our aim was to evaluate intra-observer reproducibility of shear-wave elastography (SWE) in Asian women. Sixty-four breast masses (24 malignant, 40 benign) were examined with SWE in 53 consecutive Asian women (mean age, 44.9 y old). Two SWE images were obtained for each of the lesions. The intra-observer reproducibility was assessed by intra-class correlation coefficients (ICC). We also evaluated various clinicoradiologic factors that can influence reproducibility in SWE. The ICC of intra-observer reproducibility was 0.789. In clinicoradiologic factor evaluation, masses surrounded by mixed fatty and glandular tissue (ICC: 0.619) showed lower intra-observer reproducibility compared with lesions that were surrounded by glandular tissue alone (ICC: 0.937; p < 0.05). Overall, the intra-observer reproducibility of breast SWE was excellent in Asian women. However, it may decrease when breast tissue is in a heterogeneous background. Therefore, SWE should be performed carefully in these cases. Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Process evaluation distributed system

NASA Technical Reports Server (NTRS)

Moffatt, Christopher L. (Inventor)

2006-01-01

The distributed system includes a database server, an administration module, a process evaluation module, and a data display module. The administration module is in communication with the database server for providing observation criteria information to the database server. The process evaluation module is in communication with the database server for obtaining the observation criteria information from the database server and collecting process data based on the observation criteria information. The process evaluation module utilizes a personal digital assistant (PDA). A data display module in communication with the database server, including a website for viewing collected process data in a desired metrics form, the data display module also for providing desired editing and modification of the collected process data. The connectivity established by the database server to the administration module, the process evaluation module, and the data display module, minimizes the requirement for manual input of the collected process data.

Sensing Hazards with Operational Unmanned Technology

NASA Astrophysics Data System (ADS)

Hood, R. E.

2016-12-01

The Unmanned Aircraft Systems (UAS) Program of the National Oceanic and Atmospheric Administration (NOAA) is working with the National Weather Service, the National Ocean Service, other Federal agencies, private industry, and academia to evaluate the feasibility of UAS observations to provide time critical information needed for situational awareness, prediction, warning, and damage assessment of hazards. This activity is managed within a portfolio of projects entitled "Sensing Hazards with Operational Unmanned Technology (SHOUT)." The diversity of this portfolio includes evaluations of high altitude UAS observations for high impact oceanic storms prediction to low altitude UAS observations of rivers, severe storms, and coastal areas for pre-hazard situational awareness and post-hazard damage assessments. Each SHOUT evaluation project begins with a proof-of-concept field demonstration of a UAS observing strategy for a given hazard and then matures to joint studies of both scientific data impact along with cost and operational feasibility of the observing strategy for routine applications. The technology readiness and preliminary evaulation results will be presented for several UAS observing strategies designed for improved observations of oceanic storms, floods, severe storms, and coastal ecosystem hazards.

Accuracy of remote burn scar evaluation via live video-conferencing technology.

PubMed

Cai, Lawrence Z; Caceres, Maria; Dangol, Mohan Krishna; Nakarmi, Kiran; Rai, Shankar Man; Chang, James; Gibran, Nicole S; Pham, Tam N

2016-12-05

Telemedicine in outpatient burn care, particularly in burn scar management, may provide cost-effective care and comes highly rated by patients. However, an effective scar scale using both video and photographic elements has not been validated. The purpose of this study is to test the reliability of the Patient and Observer Scar Assessment Scale (POSAS) using live video-conferencing. A prospective study was conducted with individuals with healed burn scars in Kathmandu, Nepal. Three independent observers assessed 85 burn scars from 17 subjects, using the Observer portion to evaluate vascularity, pigmentation, thickness, relief, pliability, surface area, and overall opinion. The on-site observer was physically present with the subjects and used a live videoconferencing application to show the scars to two remote observers in the United States. Subjects used the Patient portion to evaluate the scar that they believed appeared the worst appearance and had the greatest impact on function. The single-rater reliability of the Observer scale was acceptable (ICC>0.70) in overall opinion, thickness, pliability, and surface area. The average-rater reliability for three observers was acceptable (ICC>0.70) for all parameters except for vascularity. When comparing Patients' and Observers' overall opinion scores, patients consistently reported worse opinion. Evaluation of burn scars using the Patient and Observer Scar Assessment Scale can be accurately performed via live videoconferencing and presents an opportunity to expand access to burn care to rural communities, particularly in low- and middle-income countries, where patients face significant access barriers to appropriate follow-up care. Copyright © 2016 Elsevier Ltd and ISBI. All rights reserved.

Experimental evaluation of nonclassical correlations between measurement outcomes and target observable in a quantum measurement

NASA Astrophysics Data System (ADS)

Iinuma, Masataka; Suzuki, Yutaro; Nii, Taiki; Kinoshita, Ryuji; Hofmann, Holger F.

2016-03-01

In general, it is difficult to evaluate measurement errors when the initial and final conditions of the measurement make it impossible to identify the correct value of the target observable. Ozawa proposed a solution based on the operator algebra of observables which has recently been used in experiments investigating the error-disturbance trade-off of quantum measurements. Importantly, this solution makes surprisingly detailed statements about the relations between measurement outcomes and the unknown target observable. In the present paper, we investigate this relation by performing a sequence of two measurements on the polarization of a photon, so that the first measurement commutes with the target observable and the second measurement is sensitive to a complementary observable. While the initial measurement can be evaluated using classical statistics, the second measurement introduces the effects of quantum correlations between the noncommuting physical properties. By varying the resolution of the initial measurement, we can change the relative contribution of the nonclassical correlations and identify their role in the evaluation of the quantum measurement. It is shown that the most striking deviation from classical expectations is obtained at the transition between weak and strong measurements, where the competition between different statistical effects results in measurement values well outside the range of possible eigenvalues.

Movement evaluation of front crawl swimming: Technical skill versus aesthetic quality

PubMed Central

2017-01-01

The study aim was to compare expert with non-expert swimmers’ rating of the aesthetic and technical qualities of front crawl in video-taped recordings of swimmers with low, middle, and high level proficiency. The results suggest that: i) observers’ experience affects their judgment: only the expert observers correctly rated the swimmers’ proficiency level; ii) evaluation of movement (technical and aesthetic scores) is correlated with the level of skill as expressed in the kinematics of the observed action (swimming speed, stroke frequency, and stroke length); iii) expert and non-expert observers use different strategies to rate the aesthetic and technical qualities of movement: equating the technical skill with the aesthetic quality is a general rule non-expert observers follow in the evaluation of human movement. PMID:28886063

Intra-and inter-observer reliability of nailfold videocapillaroscopy - A possible outcome measure for systemic sclerosis-related microangiopathy.

PubMed

Dinsdale, Graham; Moore, Tonia; O'Leary, Neil; Tresadern, Philip; Berks, Michael; Roberts, Christopher; Manning, Joanne; Allen, John; Anderson, Marina; Cutolo, Maurizio; Hesselstrand, Roger; Howell, Kevin; Pizzorni, Carmen; Smith, Vanessa; Sulli, Alberto; Wildt, Marie; Taylor, Christopher; Murray, Andrea; Herrick, Ariane L

2017-07-01

Our aim was to assess the reliability of nailfold capillary assessment in terms of image evaluability, image severity grade ('normal', 'early', 'active', 'late'), capillary density, capillary (apex) width, and presence of giant capillaries, and also to gain further insight into differences in these parameters between patients with systemic sclerosis (SSc), patients with primary Raynaud's phenomenon (PRP) and healthy control subjects. Videocapillaroscopy images (magnification 300×) were acquired from all 10 digits from 173 participants: 101 patients with SSc, 22 with PRP and 50 healthy controls. Ten capillaroscopy experts from 7 European centres evaluated the images. Custom image mark-up software allowed extraction of the following outcome measures: overall grade ('normal', 'early', 'active', 'late', 'non-specific', or 'ungradeable'), capillary density (vessels/mm), mean vessel apical width, and presence of giant capillaries. Observers analysed a median of 129 images each. Evaluability (i.e. the availability of measures) varied across outcome measures (e.g. 73.0% for density and 46.2% for overall grade in patients with SSc). Intra-observer reliability for evaluability was consistently higher than inter- (e.g. for density, intra-class correlation coefficient [ICC] was 0.71 within and 0.14 between observers). Conditional on evaluability, both intra- and inter-observer reliability were high for grade (ICC 0.93 and 0.78 respectively), density (0.91 and 0.64) and width (0.91 and 0.85). Evaluability is one of the major challenges in assessing nailfold capillaries. However, when images are evaluable, the high intra- and inter-reliabilities suggest that overall image grade, capillary density and apex width have potential as outcome measures in longitudinal studies. Copyright © 2017 Elsevier Inc. All rights reserved.

How accurately do drivers evaluate their own driving behavior? An on-road observational study.

PubMed

Amado, Sonia; Arıkan, Elvan; Kaça, Gülin; Koyuncu, Mehmet; Turkan, B Nilay

2014-02-01

Self-assessment of driving skills became a noteworthy research subject in traffic psychology, since by knowing one's strenghts and weaknesses, drivers can take an efficient compensatory action to moderate risk and to ensure safety in hazardous environments. The current study aims to investigate drivers' self-conception of their own driving skills and behavior in relation to expert evaluations of their actual driving, by using naturalistic and systematic observation method during actual on-road driving session and to assess the different aspects of driving via comprehensive scales sensitive to different specific aspects of driving. 19-63 years old male participants (N=158) attended an on-road driving session lasting approximately 80min (45km). During the driving session, drivers' errors and violations were recorded by an expert observer. At the end of the driving session, observers completed the driver evaluation questionnaire, while drivers completed the driving self-evaluation questionnaire and Driver Behavior Questionnaire (DBQ). Low to moderate correlations between driver and observer evaluations of driving skills and behavior, mainly on errors and violations of speed and traffic lights was found. Furthermore, the robust finding that drivers evaluate their driving performance as better than the expert was replicated. Over-positive appraisal was higher among drivers with higher error/violation score and with the ones that were evaluated by the expert as "unsafe". We suggest that the traffic environment might be regulated by increasing feedback indicators of errors and violations, which in turn might increase the insight into driving performance. Improving self-awareness by training and feedback sessions might play a key role for reducing the probability of risk in their driving activity. Copyright © 2013 Elsevier Ltd. All rights reserved.

Postflight hardware evaluation 360T026 (RSRM-26, STS-47)

NASA Technical Reports Server (NTRS)

Nielson, Greg

1993-01-01

The final report for the Clearfield disassembly evaluation and a continuation of the KSC postflight assessment for the 360T026 (STS-47) Redesigned Solid Rocket Motor (RSRM) flight set is provided. All observed hardware conditions were documented on PFOR's and are included in Appendices A, B, and C. Appendices D and E contain the measurements and safety factor data for the nozzle and insulation components. This report, along with the KSC Ten-Day Postflight Hardware Evaluation Report (TWR-64203), represents a summary of the 360T026 hardware evaluation. The as-flown hardware configuration is documented in TWR-60472. Disassembly evaluation photograph numbers are logged in TWA-1987. The 360T026 flight set disassembly evaluations described were performed at the RSRM Refurbishment Facility in Clearfield, Utah. The final factory joint demate occurred on 12 April 1993. Detailed evaluations were performed in accordance with the Clearfield Postflight Engineering Evaluation Plan (PEEP), TWR-50051, Revision A. All observations were compared against limits that are also defined in the PEEP. These limits outline the criteria for categorizing the observations as acceptable, reportable, or critical. Hardware conditions that were unexpected and/or determined to be reportable or critical were evaluated by the applicable CPT and tracked through the PFAR system.

Multidetector computed tomography sizing of aortic annulus prior to transcatheter aortic valve replacement (TAVR): Variability and impact of observer experience.

PubMed

Le Couteulx, S; Caudron, J; Dubourg, B; Cauchois, G; Dupré, M; Michelin, P; Durand, E; Eltchaninoff, H; Dacher, J-N

2018-05-01

To evaluate intra- and inter-observer variability of multidetector computed tomography (MDCT) sizing of the aortic annulus before transcatheter aortic valve replacement (TAVR) and the effect of observer experience, aortic valve calcification and image quality. MDCT examinations of 52 consecutive patients with tricuspid aortic valve (30 women, 22 men) with a mean age of 83±7 (SD) years (range: 64-93 years) were evaluated retrospectively. The maximum and minimum diameters, area and circumference of the aortic annulus were measured twice at diastole and systole with a standardized approach by three independent observers with different levels of experience (expert [observer 1]; resident with intensive 6 months practice [observer 2]; trained resident with starting experience [observer 3]). Observers were requested to recommend the valve prosthesis size. Calcification volume of the aortic valve and signal to noise ratio were evaluated. Intra- and inter-observer reproducibility was excellent for all aortic annulus dimensions, with an intraclass correlation coefficient ranging respectively from 0.84 to 0.98 and from 0.82 to 0.97. Agreement for selection of prosthesis size was almost perfect between the two most experienced observers (k=0.82) and substantial with the inexperienced observer (k=0.67). Aortic valve calcification did not influence intra-observer reproducibility. Image quality influenced reproducibility of the inexperienced observer. Intra- and inter-observer variability of aortic annulus sizing by MDCT is low. Nevertheless, the less experienced observer showed lower reliability suggesting a learning curve. Copyright © 2017. Published by Elsevier Masson SAS.

Noninvariant Measurement in Rater-Mediated Assessments of Teaching Quality

ERIC Educational Resources Information Center

Kelcey, Ben

2014-01-01

Valid and reliable measurement of teaching is essential to evaluating and improving teacher effectiveness and advancing large-scale policy-relevant research in education (Raudenbush & Sadoff, 2008). One increasingly common component of teaching evaluations is the direct observation of teachers in their classrooms. Classroom observations have…

The Independence and Interdependence of Coacting Observers in Regard to Performance Efficiency, Workload, and Stress in a Vigilance Task

DTIC Science & Technology

2016-09-01

independence/ dependence , evaluation apprehension, workload, stress 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT: SAR 18. NUMBER...indepen- dence/ dependence , evaluation apprehension, workload, stress IntroductIon Vigilance or sustained attention tasks require observers to maintain

Application of Wavelet Filters in an Evaluation of Photochemical Model Performance

EPA Science Inventory

Air quality model evaluation can be enhanced with time-scale specific comparisons of outputs and observations. For example, high-frequency (hours to one day) time scale information in observed ozone is not well captured by deterministic models and its incorporation into model pe...

The development and validity of the Salford Gait Tool: an observation-based clinical gait assessment tool.

PubMed

Toro, Brigitte; Nester, Christopher J; Farren, Pauline C

2007-03-01

To develop the construct, content, and criterion validity of the Salford Gait Tool (SF-GT) and to evaluate agreement between gait observations using the SF-GT and kinematic gait data. Tool development and comparative evaluation. University in the United Kingdom. For designing construct and content validity, convenience samples of 10 children with hemiplegic, diplegic, and quadriplegic cerebral palsy (CP) and 152 physical therapy students and 4 physical therapists were recruited. For developing criterion validity, kinematic gait data of 13 gait clusters containing 56 children with hemiplegic, diplegic, and quadriplegic CP and 11 neurologically intact children was used. For clinical evaluation, a convenience sample of 23 pediatric physical therapists participated. We developed a sagittal plane observational gait assessment tool through a series of design, test, and redesign iterations. The tool's grading system was calibrated using kinematic gait data of 13 gait clusters and was evaluated by comparing the agreement of gait observations using the SF-GT with kinematic gait data. Criterion standard kinematic gait data. There was 58% mean agreement based on grading categories and 80% mean agreement based on degree estimations evaluated with the least significant difference method. The new SF-GT has good concurrent criterion validity.

Overall gloss evaluation in the presence of multiple cues to surface glossiness.

PubMed

Leloup, Frédéric B; Pointer, Michael R; Dutré, Philip; Hanselaer, Peter

2012-06-01

Human observers use the information offered by various visual cues when evaluating the glossiness of a surface. Several studies have demonstrated the effect of each single cue to glossiness, but little has been reported on how multiple cues are integrated for the perception of surface gloss. This paper reports on a psychophysical study with real stimuli that are different regarding multiple visual gloss criteria. Four samples were presented to 15 observers under different conditions of illumination in a light booth, resulting in a series of 16 stimuli. Through pairwise comparisons, an overall gloss scale was derived, from which it could be concluded that both differences in the distinctness of the reflected image and differences in luminance affect gloss perception. However, an investigation of the observers' strategy to evaluate gloss indicated a dichotomy among observers. One group of observers used the distinctness-of-image as a principal cue to glossiness, while the second group evaluated gloss primarily from differences in luminance of both the specular highlight and the diffuse background. It could therefore be questioned whether surface gloss can be characterized with one single quantity, or that a set of quantities is necessary to describe the gloss differences between objects.

Evaluation of Multiclass Model Observers in PET LROC Studies

NASA Astrophysics Data System (ADS)

Gifford, H. C.; Kinahan, P. E.; Lartizien, C.; King, M. A.

2007-02-01

A localization ROC (LROC) study was conducted to evaluate nonprewhitening matched-filter (NPW) and channelized NPW (CNPW) versions of a multiclass model observer as predictors of human tumor-detection performance with PET images. Target localization is explicitly performed by these model observers. Tumors were placed in the liver, lungs, and background soft tissue of a mathematical phantom, and the data simulation modeled a full-3D acquisition mode. Reconstructions were performed with the FORE+AWOSEM algorithm. The LROC study measured observer performance with 2D images consisting of either coronal, sagittal, or transverse views of the same set of cases. Versions of the CNPW observer based on two previously published difference-of-Gaussian channel models demonstrated good quantitative agreement with human observers. One interpretation of these results treats the CNPW observer as a channelized Hotelling observer with implicit internal noise

Development of a Rubric for Collegiate Jazz Improvisation Performance Assessment

ERIC Educational Resources Information Center

Moore, Kendall Ryan

2016-01-01

The purpose of this study was to develop a jazz improvisation rubric for the evaluation of collegiate jazz improvisation. To create this measure, research objectives were devised to investigate the aurally-observed performer-controlled components of improvisation, which aurally-observed components should be evaluated in an improvisatory…

Use of Propensity Score Matching for Training Research with Observational Data

ERIC Educational Resources Information Center

Gemici, Sinan; Rojewski, Jay W.; Lee, In Heok

2012-01-01

Evaluations of vocational education and training (VET) programs play a key role in informing training policy in Australia and elsewhere. Increasingly, such evaluations use observational data from surveys or administrative collections to assess the effectiveness of VET programs and interventions. The difficulty associated with using observational…

Exploring Classroom Walkthroughs: A Case Study of School Leaders' Learning and Professional Growth

ERIC Educational Resources Information Center

Rodrigue, Lorrie

2013-01-01

Connecticut's System for Educator Evaluation and Development (SEED) has required the practice of classroom observations to ensure school leaders regularly monitor instruction in their schools and districts. However, literature suggests the use of non-evaluative, less formal classroom observations may also provide school leaders' with opportunities…

Assessing the Student-Instructional Setting Interface Using an Eco-Behavioral Observation System.

ERIC Educational Resources Information Center

Hendrickson, Jo M.

1992-01-01

An eco-behavioral observation system was developed for use with students with behavior disorders or emotional disturbances. Discussed are the ecosystem definition, the student-instructional setting interface, and the assessment procedure, including evaluation of the quality of academic responding, program evaluation, staff development, and…

Evaluation of Immediate Actions Taken to Deal with Cracking Problems Observed in Wheels of Rail Commuter Cars

DOT National Transportation Integrated Search

1993-07-01

The report is the first in a series of engineering studies on railroad vehicle wheel performance. Preliminary studies are summarized, involving evaluation of actions taken to respond to high rates of crack occurrence observed in the wheels of certain...

Examining Interrater Agreement Analyses of a Pilot Special Education Observation Tool

ERIC Educational Resources Information Center

Johnson, Evelyn S.; Semmelroth, Carrie L.

2012-01-01

This paper reports the results of interrater agreement analyses on a pilot special education teacher evaluation instrument, the Recognizing Effective Special Education Teachers (RESET) Observation Tool (OT). Using evidence-based instructional practices as the basis for the evaluation, the RESET OT is designed for the spectrum of different…

Administrators' Perceptions Regarding the Effectiveness of the Teacher Observation Evaluation System

ERIC Educational Resources Information Center

Williams, Kathleen Riley

2015-01-01

This phenomenological narrative study was designed to explore public school administrators' perceptions regarding Louisiana's Compass teacher observation evaluation system as a method for assessing teacher performance. Participants were administrators with at least two years of experience as a public school administrator at the secondary level,…

The Development and Validation of the Inquiry Science Observation Coding Sheet

ERIC Educational Resources Information Center

Brandon, P. R.; Taum, A. K. H.; Young, D. B.; Pottenger, F. M., III

2008-01-01

Evaluation reports increasingly document the degree of program implementation, particularly the extent to which programs adhere to prescribed steps and procedures. Many reports are cursory, however, and few, if any, fully portray the long and winding path taken when developing evaluation instruments, particularly observation instruments. In this…

TThe role of nitrogen availability in land-atmosphere interactions: a systematic evaluation of carbon-nitrogen coupling in a global land surface model using plot-level nitrogen fertilization experiments

NASA Astrophysics Data System (ADS)

Thomas, R. Q.; Goodale, C. L.; Bonan, G. B.; Mahowald, N. M.; Ricciuto, D. M.; Thornton, P. E.

2010-12-01

Recent research from global land surface models emphasizes the important role of nitrogen cycling on global climate, via its control on the terrestrial carbon balance. Despite the implications of nitrogen cycling on global climate predictions, the research community has not performed a systematic evaluation of nitrogen cycling in global models. Here, we present such an evaluation for one global land model, CLM-CN. In the evaluation we simulated 45 plot-scale nitrogen-fertilization experiments distributed across 33 temperate and boreal forest sites. Model predictions were evaluated against field observations by comparing the vegetation and soil carbon responses to the additional nitrogen. Aggregated across all experiments, the model predicted a larger vegetation carbon response and a smaller soil carbon response than observed; the responses partially offset each other, leading to a slightly larger total ecosystem carbon response than observed. However, the model-observation agreement improved for vegetation carbon when the sites with observed negative carbon responses to nitrogen were excluded, which may be because the model lacks mechanisms whereby nitrogen additions increase tree mortality. Among experiments, younger forests and boreal forests’ vegetation carbon responses were less than predicted and mature forests (> 40 years old) were greater than predicted. Specific to the CLM-CN, this study used a systematic evaluation to identify key areas to focus model development, especially soil carbon- nitrogen interactions and boreal forest nitrogen cycling. Applicable to the modeling community, this study demonstrates a standardized protocol for comparing carbon-nitrogen interactions among global land models.

Evaluation of a pilot peer observation of teaching scheme for chair-side tutors at Glasgow University Dental School.

PubMed

Cairns, A M; Bissell, V; Bovill, C

2013-06-01

To introduce and examine a pilot peer observation of teaching (POT) scheme within the Department of Paediatric Dentistry at Glasgow Dental School and its associated outreach centres. All tutors teaching paediatric dentistry were invited to be involved in evaluation of the POT scheme. Participants were randomly paired with a peer, who then observed their teaching and provided constructive feedback. For those consenting to be involved in the evaluation of the scheme, semi-structured, one-to-one interviews were carried out by the principal investigator. POT was found by all participants to be a beneficial process, reassuring those of their teaching styles and giving them ideas to adapt their teaching. POT is an effective method for engaging chair-side tutors in the reflection and development of their teaching practice via observations and scholarly discussion.

Evaluation of Biogenic and Fire Emissions in a Global Chemistry Model with NOMADSS, DC3 and SEAC4RS observations

NASA Astrophysics Data System (ADS)

Emmons, L. K.; Wiedinmyer, C.; Park, M.; Kaser, L.; Apel, E. C.; Guenther, A. B.

2014-12-01

Numerous measurements of compounds produced by biogenic and fire emissions were made during several recent field campaigns in the southeast United States, providing a unique data set for emissions and chemical model evaluation. The NCAR Community Atmosphere Model with Chemistry (CAM-chem) is coupled to the Community Land Model (CLM), which includes the biogenic emissions model MEGAN-v2.1, allowing for online calculation of emissions from vegetation for 150 compounds. Simulations of CAM-chem for summers 2012 and 2013 are evaluated with the aircraft and ground-based observations from DC3, NOMADSS and SEAC4RS. Comparison of directly emitted biogenic species, such as isoprene, terpenes, methanol and acetone, are used to evaluate the MEGAN emissions. Evaluation of oxidation products, including methyl vinyl ketone (MVK), methacrolein, formaldehyde, and other oxygenated VOCs are used to test the model chemistry mechanism. In addition, several biomass burning inventories are used in the model, including FINN, QFED, and FLAMBE, and are compared for their impact on atmospheric composition and ozone production, and evaluated with the aircraft observations.

Evolution in Cloud Population Statistics of the MJO: From AMIE Field Observations to Global Cloud-Permiting Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Chidong

Motivated by the success of the AMIE/DYNAMO field campaign, which collected unprecedented observations of cloud and precipitation from the tropical Indian Ocean in Octber 2011 – March 2012, this project explored how such observations can be applied to assist the development of global cloud-permitting models through evaluating and correcting model biases in cloud statistics. The main accomplishment of this project were made in four categories: generating observational products for model evaluation, using AMIE/DYNAMO observations to validate global model simulations, using AMIE/DYNAMO observations in numerical studies of cloud-permitting models, and providing leadership in the field. Results from this project provide valuablemore » information for building a seamless bridge between DOE ASR program’s component on process level understanding of cloud processes in the tropics and RGCM focus on global variability and regional extremes. In particular, experience gained from this project would be directly applicable to evaluation and improvements of ACME, especially as it transitions to a non-hydrostatic variable resolution model.« less

Application of Observing System Simulation Experiments (OSSEs) to determining science and user requirements for space-based missions

NASA Astrophysics Data System (ADS)

Atlas, R. M.

2016-12-01

Observing System Simulation Experiments (OSSEs) provide an effective method for evaluating the potential impact of proposed new observing systems, as well as for evaluating trade-offs in observing system design, and in developing and assessing improved methodology for assimilating new observations. As such, OSSEs can be an important tool for determining science and user requirements, and for incorporating these requirements into the planning for future missions. Detailed OSSEs have been conducted at NASA/ GSFC and NOAA/AOML in collaboration with Simpson Weather Associates and operational data assimilation centers over the last three decades. These OSSEs determined correctly the quantitative potential for several proposed satellite observing systems to improve weather analysis and prediction prior to their launch, evaluated trade-offs in orbits, coverage and accuracy for space-based wind lidars, and were used in the development of the methodology that led to the first beneficial impacts of satellite surface winds on numerical weather prediction. In this talk, the speaker will summarize the development of OSSE methodology, early and current applications of OSSEs and how OSSEs will evolve in order to enhance mission planning.

Utilizing visual art to enhance the clinical observation skills of medical students.

PubMed

Jasani, Sona K; Saks, Norma S

2013-07-01

Clinical observation is fundamental in practicing medicine, but these skills are rarely taught. Currently no evidence-based exercises/courses exist for medical student training in observation skills. The goal was to develop and teach a visual arts-based exercise for medical students, and to evaluate its usefulness in enhancing observation skills in clinical diagnosis. A pre- and posttest and evaluation survey were developed for a three-hour exercise presented to medical students just before starting clerkships. Students were provided with questions to guide discussion of both representational and non-representational works of art. Quantitative analysis revealed that the mean number of observations between pre- and posttests was not significantly different (n=70: 8.63 vs. 9.13, p=0.22). Qualitative analysis of written responses identified four themes: (1) use of subjective terminology, (2) scope of interpretations, (3) speculative thinking, and (4) use of visual analogies. Evaluative comments indicated that students felt the exercise enhanced both mindfulness and skills. Using visual art images with guided questions can train medical students in observation skills. This exercise can be replicated without specially trained personnel or art museum partnerships.

University Evaluations and Different Evaluation Approaches: A Finnish Perspective

ERIC Educational Resources Information Center

Liuhanen, Anna-Maija

2005-01-01

Evaluation of higher education can be described a species of its own with only few connections with other fields of evaluation. When considering the future developments in higher education evaluation (quality assurance), it is useful to observe its similarities and differences with various evaluation approaches in other than higher education…

Evaluation of Unmanned Aircraft Systems (UAS) for Weather and Climate using the Multi-testbed approach

NASA Astrophysics Data System (ADS)

Baker, B.; Lee, T.; Buban, M.; Dumas, E. J.

2017-12-01

Evaluation of Unmanned Aircraft Systems (UAS) for Weather and Climate using the Multi-testbed approachC. Bruce Baker1, Ed Dumas1,2, Temple Lee1,2, Michael Buban1,21NOAA ARL, Atmospheric Turbulence and Diffusion Division, Oak Ridge, TN2Oak Ridge Associated Universities, Oak Ridge, TN The development of a small Unmanned Aerial System (sUAS) testbeds that can be used to validate, integrate, calibrate and evaluate new technology and sensors for routine boundary layer research, validation of operational weather models, improvement of model parameterizations, and recording observations within high-impact storms is important for understanding the importance and impact of using sUAS's routinely as a new observing platform. The goal of the multi-testbed approach is to build a robust set of protocols to assess the cost and operational feasibility of unmanned observations for routine applications using various combinations of sUAS aircraft and sensors in different locations and field experiments. All of these observational testbeds serve different community needs, but they also use a diverse suite of methodologies for calibration and evaluation of different sensors and platforms for severe weather and boundary layer research. The primary focus will be to evaluate meteorological sensor payloads to measure thermodynamic parameters and define surface characteristics with visible, IR, and multi-spectral cameras. This evaluation will lead to recommendations for sensor payloads for VTOL and fixed-wing sUAS.

Psychometric Characteristics of Process Evaluation Measures for a Rural School-based Childhood Obesity Prevention Study: Louisiana Health

PubMed Central

Newton, R. L.; Thomson, J. L.; Rau, K.; Duhe’, S.; Sample, A.; Singleton, N.; Anton, S. D.; Webber, L. S.; Williamson, D. A.

2011-01-01

Purpose To evaluate the implementation of intervention components of the Louisiana Health study, which was a multi-component childhood obesity prevention program conducted in rural schools. Design Content analysis. Setting Process evaluation assessed implementation in the classrooms, gym classes, and cafeterias. Subjects Classroom teachers (n = 232), physical education teachers (n = 53), food service managers (n = 33), and trained observers (n = 9). Measures Five process evaluation measures were created: Physical Education Questionnaire (PEQ), Intervention Questionnaire (IQ), Food Service Manager Questionnaire (FSMQ), Classroom Observation (CO) and School Nutrition Environment Observation (SNEO). Analysis Inter-rater reliability and internal consistency were conducted on all measures. ANOVA and Chi-square were used to compare differences across study groups on questionnaires and observations. Results The PEQ and one sub-scale from the FSMQ were eliminated because their reliability coefficients fell below acceptable standards. The sub-scale internal consistencies for the IQ, FSMQ, CO, and SNEO (all Cronbach’s α > .60) were acceptable. Conclusions After the initial 4 months of intervention, there was evidence that the Louisiana Health intervention was being implemented as it was designed. In summary, four process evaluation measures were found to be sufficiently reliable and valid for assessing the delivery of various aspects of a school-based obesity prevention program. These process measures could be modified to evaluate the delivery of other similar school-based interventions. PMID:21721969

Psychometric characteristics of process evaluation measures for a rural school-based childhood obesity prevention study: Louisiana Health.

PubMed

Newton, Robert L; Thomson, Jessica L; Rau, Kristi K; Ragusa, Shelly A; Sample, Alicia D; Singleton, Nakisha N; Anton, Stephen D; Webber, Larry S; Williamson, Donald A

2011-01-01

To evaluate the implementation of intervention components of the Louisiana Health study, which was a multicomponent childhood obesity prevention program conducted in rural schools. Content analysis. Process evaluation assessed implementation in classrooms, gym classes, and cafeterias. Classroom teachers (n  =  232), physical education teachers (n  =  53), food service managers (n  =  33), and trained observers (n  =  9). Five process evaluation measures were created: Physical Education Questionnaire (PEQ), Intervention Questionnaire (IQ), Food Service Manager Questionnaire (FSMQ), Classroom Observation (CO), and School Nutrition Environment Observation (SNEO). Interrater reliability and internal consistency were assessed on all measures. Analysis of variance and χ(2) were used to compare differences across study groups on questionnaires and observations. The PEQ and one subscale from the FSMQ were eliminated because their reliability coefficients fell below acceptable standards. The subscale internal consistencies for the IQ, FSMQ, CO, and SNEO (all Cronbach α > .60) were acceptable. After the initial 4 months of intervention, there was evidence that the Louisiana Health intervention was being implemented as it was designed. In summary, four process evaluation measures were found to be sufficiently reliable and valid for assessing the delivery of various aspects of a school-based obesity prevention program. These process measures could be modified to evaluate the delivery of other similar school-based interventions.

Parameter and observation importance in modelling virus transport in saturated porous media - Investigations in a homogenous system

USGS Publications Warehouse

Barth, Gilbert R.; Hill, M.C.

2005-01-01

This paper evaluates the importance of seven types of parameters to virus transport: hydraulic conductivity, porosity, dispersivity, sorption rate and distribution coefficient (representing physical-chemical filtration), and in-solution and adsorbed inactivation (representing virus inactivation). The first three parameters relate to subsurface transport in general while the last four, the sorption rate, distribution coefficient, and in-solution and adsorbed inactivation rates, represent the interaction of viruses with the porous medium and their ability to persist. The importance of four types of observations to estimate the virus-transport parameters are evaluated: hydraulic heads, flow, temporal moments of conservative-transport concentrations, and virus concentrations. The evaluations are conducted using one- and two-dimensional homogeneous simulations, designed from published field experiments, and recently developed sensitivity-analysis methods. Sensitivity to the transport-simulation time-step size is used to evaluate the importance of numerical solution difficulties. Results suggest that hydraulic conductivity, porosity, and sorption are most important to virus-transport predictions. Most observation types provide substantial information about hydraulic conductivity and porosity; only virus-concentration observations provide information about sorption and inactivation. The observations are not sufficient to estimate these important parameters uniquely. Even with all observation types, there is extreme parameter correlation between porosity and hydraulic conductivity and between the sorption rate and in-solution inactivation. Parameter estimation was accomplished by fixing values of porosity and in-solution inactivation.

Program management model study

NASA Technical Reports Server (NTRS)

Connelly, J. J.; Russell, J. E.; Seline, J. R.; Sumner, N. R., Jr.

1972-01-01

Two models, a system performance model and a program assessment model, have been developed to assist NASA management in the evaluation of development alternatives for the Earth Observations Program. Two computer models were developed and demonstrated on the Goddard Space Flight Center Computer Facility. Procedures have been outlined to guide the user of the models through specific evaluation processes, and the preparation of inputs describing earth observation needs and earth observation technology. These models are intended to assist NASA in increasing the effectiveness of the overall Earth Observation Program by providing a broader view of system and program development alternatives.

Redesigning and aligning assessment and evaluation for a federally funded math and science teacher educational program.

PubMed

Hardré, Patricia L; Slater, Janis; Nanny, Mark

2010-11-01

This paper examines the redesign of evaluation components for a teacher professional development project funded by the National Science Foundation. It focuses on aligning evaluation instrumentation and strategies with program goals, research goals and program evaluation best practices. The study identifies weaknesses in the original (year 1) program evaluation design and implementation, develops strategies and tracks changes for year 2 implementation, and then reports enhancement of findings and recommendations for year 3. It includes lessons learned about assessment and evaluation over the project lifespan, with implications for research and evaluation of a range of related programs. This study functions as a classic illustration of how critical it is to observe first principles of assessment and evaluation for funded programs, the risks that arise when they are ignored, and the benefits that accrue when they are systematically observed. Copyright (c) 2009. Published by Elsevier Ltd.

Final postflight hardware evaluation report RSRM-28 (STS-53)

NASA Technical Reports Server (NTRS)

Starrett, William David, Jr.

1993-01-01

The final report for the Clearfield disassembly evaluation and a continuation of the KSC postflight assessment for the RSRM-28 (STS-53) RSRM flight set is presented. All observed hardware conditions were documented on PFOR's and are included in Appendices A through C. Appendices D and E contain the measurements and safety factor data for the nozzle and insulation components. This report, along with the KSC Ten-Day Postflight Hardware Evaluation Report (TWR-64215), represents a summary of the RSRM-28 hardware evaluation. The as-flown hardware configuration is documented in TWR-63638. Disassembly evaluation photograph numbers are logged in TWA-1989. The RSRM-28 flight set disassembly evaluations described were performed at the RSRM Refurbishment Facility in Clearfield, Utah. The final factory joint demate occurred on July 15, 1993. Additional time was required to perform the evaluation of the stiffener rings per special issue 4.1.5.2 because of the washout schedule. The release of this report was after completion of all special issues per program management direction. Detailed evaluations were performed in accordance with the Clearfield PEEP, TWR-50051, Revision A. All observations were compared against limits that are also defined in the PEEP. These limits outline the criteria for categorizing the observations as acceptable, reportable, or critical. Hardware conditions that were unexpected and/or determined to be reportable or critical were evaluated by the applicable team and tracked through the PFAR system.

Values of a Patient and Observer Scar Assessment Scale to Evaluate the Facial Skin Graft Scar.

PubMed

Chae, Jin Kyung; Kim, Jeong Hee; Kim, Eun Jung; Park, Kun

2016-10-01

The patient and observer scar assessment scale (POSAS) recently emerged as a promising method, reflecting both observer's and patient's opinions in evaluating scar. This tool was shown to be consistent and reliable in burn scar assessment, but it has not been tested in the setting of skin graft scar in skin cancer patients. To evaluate facial skin graft scar applied to POSAS and to compare with objective scar assessment tools. Twenty three patients, who diagnosed with facial cutaneous malignancy and transplanted skin after Mohs micrographic surgery, were recruited. Observer assessment was performed by three independent rates using the observer component of the POSAS and Vancouver scar scale (VSS). Patient self-assessment was performed using the patient component of the POSAS. To quantify scar color and scar thickness more objectively, spectrophotometer and ultrasonography was applied. Inter-observer reliability was substantial with both VSS and the observer component of the POSAS (average measure intraclass coefficient correlation, 0.76 and 0.80, respectively). The observer component consistently showed significant correlations with patients' ratings for the parameters of the POSAS (all p -values<0.05). The correlation between subjective assessment using POSAS and objective assessment using spectrophotometer and ultrasonography showed low relationship. In facial skin graft scar assessment in skin cancer patients, the POSAS showed acceptable inter-observer reliability. This tool was more comprehensive and had higher correlation with patient's opinion.

Status and the evaluation of workplace deviance.

PubMed

Bowles, Hannah Riley; Gelfand, Michele

2010-01-01

Bias in the evaluation of workplace misbehavior is hotly debated in courts and corporations, but it has received little empirical attention. Classic sociological literature suggests that deviance by lower-status actors will be evaluated more harshly than deviance by higher-status actors. However, more recent psychological literature suggests that discrimination in the evaluation of misbehavior may be moderated by the relative status of the evaluator because status influences both rule observance and attitudes toward social hierarchy. In Study 1, the psychological experience of higher status decreased rule observance and increased preferences for social hierarchy, as we theorized. In three subsequent experiments, we tested the hypothesis that higher-status evaluators would be more discriminating in their evaluations of workplace misbehavior, evaluating fellow higher-status deviants more leniently than lower-status deviants. Results supported the hypothesized interactive effect of evaluator status and target status on the evaluation of workplace deviance, when both achieved status characteristics (Studies 2a and 2b) and ascribed status characteristics (i.e., race and gender in Study 3) were manipulated.

Second-Order Beliefs about Intention and Children's Attributions of Sociomoral Judgment

ERIC Educational Resources Information Center

Shiverick, Sean M.; Moore, Colleen F.

2007-01-01

Predicting how another person will evaluate the intention underlying an action involves consideration of second-order mental states. Children (ages 5-10 years) and college students (N=105) predicted an observer's belief about an actor's intention and evaluated the actor from both their own perspectives and the perspective of the observer. Younger…

Assessing Multi-year Changes in Modeled and Observed Urban NOx Concentrations from a Dynamic Model Evaluation Perspective

EPA Science Inventory

An investigation of the concentrations of nitrogen oxides (NOx) from an air quality model and observations at monitoring sites was performed to assess the changes in NOx levels attributable to changes in mobile emissions. This evaluation effort focused on weekday morning rush hou...

Examining the Return on Investment of Test and Evaluation

DTIC Science & Technology

2015-03-26

Problem Discovery Cases Observed in DOT&E Oversight Programs ............... 4 Figure 2. DoD T&E Organizational Structure...11 Figure 3. Product Maturity Levels Commercial Firms Seek to Validate ........................ 23 Figure 4 ...beginning in its fiscal year (FY) 2011 report, the Director, Operational Test and Evaluation (DOT&E), started reporting significant issues observed

Instructional Supervision: A Descriptive Study Focusing on the Observation and Evaluation of Teachers in Cyberschools

ERIC Educational Resources Information Center

Farley, Gregory Charles

2010-01-01

Since 1996, K-12 schools are increasingly moving from a traditional, face-to-face educational environment to an online learning environment utilizing technologies to deliver instruction primarily via the Internet. As this trend continues, administrators familiar with traditional supervisory methods will observe and evaluate teachers of online…

Evaluating the Effectiveness of READ 180: A Reading Program for Struggling Middle School Students

ERIC Educational Resources Information Center

Johnson, Latonya R.

2011-01-01

This study was conducted using a qualitative approach to evaluate the effectiveness of READ 180 Program in improving students reading interests and achievement at West Bolivar Middle School (WBMS). A number of interviews and observations were conducted. Two teachers and nine students were interviewed, and nine classroom observations were…

Observational and Incidental Learning by Children with Autism during Small Group Instruction

ERIC Educational Resources Information Center

Ledford, Jennifer R.; Gast, David L.; Luscre, Deanna; Ayres, Kevin M.

2008-01-01

This study evaluated the acquisition of incidental and observational information presented to 6 children with autism in a small group instructional arrangement using a constant time delay (CTD) procedure. A multiple probe design across behaviors, replicated across 6 participants, was used to evaluate the effectiveness of the CTD procedure and to…

Practical Hints for Observational Research.

ERIC Educational Resources Information Center

Washington, Wanda; And Others

The Austin Independent School District's Research and Evaluation Office presents practical information concerning observational research. This paper focuses on five topics: (1) what makes a good observer (setting the ground rules, training observers in details, and practice, i.e., involving the observers in planning and providing rigorous…

The Dependability of Classroom Observations.

ERIC Educational Resources Information Center

Hiatt, Diana Buell; Keesling, J. Ward

A generalizability study of timed observations was conducted in 25 primary grade classes to observe teachers' use of time--for instruction, evaluation of instruction, and classroom management--according to the hour and day observed. Observational methods used by on-site researchers included videotape, checklists, running documentaries, frequency…

Impact of Targeted Ocean Observations for Improving Ocean Model Initialization for Coupled Hurricane Forecasting

NASA Astrophysics Data System (ADS)

Halliwell, G. R.; Srinivasan, A.; Kourafalou, V. H.; Yang, H.; Le Henaff, M.; Atlas, R. M.

2012-12-01

The accuracy of hurricane intensity forecasts produced by coupled forecast models is influenced by errors and biases in SST forecasts produced by the ocean model component and the resulting impact on the enthalpy flux from ocean to atmosphere that powers the storm. Errors and biases in fields used to initialize the ocean model seriously degrade SST forecast accuracy. One strategy for improving ocean model initialization is to design a targeted observing program using airplanes and in-situ devices such as floats and drifters so that assimilation of the additional data substantially reduces errors in the ocean analysis system that provides the initial fields. Given the complexity and expense of obtaining these additional observations, observing system design methods such as OSSEs are attractive for designing efficient observing strategies. A new fraternal-twin ocean OSSE system based on the HYbrid Coordinate Ocean Model (HYCOM) is used to assess the impact of targeted ocean profiles observed by hurricane research aircraft, and also by in-situ float and drifter deployments, on reducing errors in initial ocean fields. A 0.04-degree HYCOM simulation of the Gulf of Mexico is evaluated as the nature run by determining that important ocean circulation features such as the Loop Current and synoptic cyclones and anticyclones are realistically simulated. The data-assimilation system is run on a 0.08-degree HYCOM mesh with substantially different model configuration than the nature run, and it uses a new ENsemble Kalman Filter (ENKF) algorithm optimized for the ocean model's hybrid vertical coordinates. The OSSE system is evaluated and calibrated by first running Observing System Experiments (OSEs) to evaluate existing observing systems, specifically quantifying the impact of assimilating more than one satellite altimeter, and also the impact of assimilating targeted ocean profiles taken by the NOAA WP-3D hurricane research aircraft in the Gulf of Mexico during the Deepwater Horizon oil spill. OSSE evaluation and calibration is then performed by repeating these two OSEs with synthetic observations and comparing the resulting observing system impact to determine if it differs from the OSE results. OSSEs are first run to evaluate different airborne sampling strategies with respect to temporal frequency of flights and the horizontal separation of upper-ocean profiles during each flight. They are then run to assess the impact of releasing multiple floats and gliders. Evaluation strategy focuses on error reduction in fields important for hurricane forecasting such as the structure of ocean currents and eddies, upper ocean heat content distribution, and upper-ocean stratification.

Evaluation of Open-Source Hard Real Time Software Packages

NASA Technical Reports Server (NTRS)

Mattei, Nicholas S.

2004-01-01

Reliable software is, at times, hard to find. No piece of software can be guaranteed to work in every situation that may arise during its use here at Glenn Research Center or in space. The job of the Software Assurance (SA) group in the Risk Management Office is to rigorously test the software in an effort to ensure it matches the contract specifications. In some cases the SA team also researches new alternatives for selected software packages. This testing and research is an integral part of the department of Safety and Mission Assurance. Real Time operation in reference to a computer system is a particular style of handing the timing and manner with which inputs and outputs are handled. A real time system executes these commands and appropriate processing within a defined timing constraint. Within this definition there are two other classifications of real time systems: hard and soft. A soft real time system is one in which if the particular timing constraints are not rigidly met there will be no critical results. On the other hand, a hard real time system is one in which if the timing constraints are not met the results could be catastrophic. An example of a soft real time system is a DVD decoder. If the particular piece of data from the input is not decoded and displayed to the screen at exactly the correct moment nothing critical will become of it, the user may not even notice it. However, a hard real time system is needed to control the timing of fuel injections or steering on the Space Shuttle; a delay of even a fraction of a second could be catastrophic in such a complex system. The current real time system employed by most NASA projects is Wind River's VxWorks operating system. This is a proprietary operating system that can be configured to work with many of NASA s needs and it provides very accurate and reliable hard real time performance. The down side is that since it is a proprietary operating system it is also costly to implement. The prospect of replacing this somewhat costly implementation is the focus of one of the SA group s current research projects. The explosion of open source software in the last ten years has led to the development of a multitude of software solutions which were once only produced by major corporations. The benefits of these open projects include faster release and bug patching cycles as well as inexpensive if not free software solutions. The main packages for hard real time solutions under Linux are Real Time Application Interface (RTAI) and two varieties of Real Time Linux (RTL), RTLFree and RTLPro. During my time here at NASA I have been testing various hard real time solutions operating as layers on the Linux Operating System. All testing is being run on an Intel SBC 2590 which is a common embedded hardware platform. The test plan was provided to me by the Software Assurance group at the start of my internship and my job has been to test the systems by developing and executing the test cases on the hardware. These tests are constructed so that the Software Assurance group can get hard test data for a comparison between the open source and proprietary implementations of hard real time solutions.

The importance of standardized observations to evaluate nutritional care quality in the survey process.

PubMed

Schnelle, John F; Bertrand, Rosanna; Hurd, Donna; White, Alan; Squires, David; Feuerberg, Marvin; Hickey, Kelly; Simmons, Sandra F

2009-10-01

Guidelines written for government surveyors who assess nursing home (NH) compliance with federal standards contain instructions to observe the quality of mealtime assistance. However, these instructions are vague and no protocol is provided for surveyors to record observational data. This study compared government survey staff observations of mealtime assistance quality to observations by research staff using a standardized protocol that met basic standards for accurate behavioral measurement. Survey staff used either the observation instructions in the standard survey process or those written for the revised Quality Improvement Survey (QIS). Trained research staff observed mealtime care in 20 NHs in 5 states during the same time period that survey staff evaluated care in the same facilities, although it could not be determined if survey and research staff observed the same residents during the same meals. Ten NHs were evaluated by government surveyors using the QIS survey instructions and 10 NHs were evaluated by surveyors using the standard survey instructions. Research staff observations using a standardized observation protocol identified a higher proportion of residents receiving inadequate feeding assistance during meals relative to survey staff using either the standard or QIS survey instructions. For example, more than 50% of the residents who ate less than half of their meals based on research staff observation were not offered an alternative to the served meal, and the lack of alternatives, or meal substitutions, was common in all 20 NHs. In comparison, the QIS survey teams documented only 2 instances when meal substitutes were not offered in 10 NHs and the standard survey teams documented no instances in 10 NHs. Standardized mealtime observations by research staff revealed feeding assistance care quality issues in all 20 study NHs. Surveyors following the instructions in either the standard or revised QIS surveys did not detect most of these care quality issues. Survey staff instructions for observation of nutritional care are not clearly written; thus, these instructions do not permit accurate behavioral measurement. These instructions should be revised in consideration of basic principles that guide accurate behavioral measurement and shared with NH providers to enable them to effectively implement quality improvement programs.

[Teamwork in the operating theatre: the German Observational Teamwork Assessment for Surgery (OTAS-D) and its first application in Germany].

PubMed

Passauer-Baierl, S; Chiapponi, C; Bruns, C J; Weigl, M

2014-12-01

The quality of surgical teamwork contributes to performance of the operating theatre team, service quality and patient safety in surgery. Observational tools are a feasible and reliable way to capture and evaluate teamwork in the operating theatre (OT). We introduce the German version of the Observational Teamwork Assessment for Surgery (OTAS-D) and present the first observational results from German OTs. Quality of surgical teamwork was assessed with observational teamwork assessment for surgery (OTAS-D). It evaluates five dimensions of OT teamwork: communication, coordination, cooperation/backup behaviour, leadership, and team monitoring/situation awareness. Each dimension is evaluated for each profession (surgical, nursing, and anaesthesia team) as well for each phase of the procedure (pre-, intra-, and post-operative). We observed n = 63 procedures, mainly in abdominal/general and orthopaedic surgery. Additionally, all OT team members scored their individual evaluation of the intra-operative teamwork (standardised 1-item questions). The OTAS-D evaluations showed meaningful results and differences for the OT professions as well as across the different phases of the procedures. Overall, a medium to good level of the OT teamwork was observed. There were no differences in regard to type of surgery (minimally invasive vs. open) or surgical specialties. With an increased coordination of the surgical team we observed a significantly increased cooperation of the nursing team (r = 0.36, p = 0.004). Concerning the OT staffs self-reports, the surgical and nursing teams reported higher scores for quality of surgical teamwork during the procedure than their anaesthesia team members. No significant relationships between observed quality of OT teamwork and self-reports were found. The German version of OTAS-D is a psychometrically robust method to capture the quality of teamwork in operating theatres. It enables the analyses of teamwork between the surgical, nursing and anaesthesia professions in acute surgical care. Limitations of the first application results are considered. Finally, potential applications for surgical teaching, research and quality management are discussed. Georg Thieme Verlag KG Stuttgart · New York.

CMAQ Involvement in Air Quality Model Evaluation International Initiative

EPA Pesticide Factsheets

Description of Air Quality Model Evaluation International Initiative (AQMEII). Different chemical transport models are applied by different groups over North America and Europe and evaluated against observations.

Seed Placement in Permanent Breast Seed Implant Brachytherapy: Are Concerns Over Accuracy Valid?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morton, Daniel, E-mail: dmorton@bccancer.bc.ca; Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia; Hilts, Michelle

Purpose: To evaluate seed placement accuracy in permanent breast seed implant brachytherapy (PBSI), to identify any systematic errors and evaluate their effect on dosimetry. Methods and Materials: Treatment plans and postimplant computed tomography scans for 20 PBSI patients were spatially registered and used to evaluate differences between planned and implanted seed positions, termed seed displacements. For each patient, the mean total and directional seed displacements were determined in both standard room coordinates and in needle coordinates relative to needle insertion angle. Seeds were labeled according to their proximity to the anatomy within the breast, to evaluate the influence of anatomicmore » regions on seed placement. Dosimetry within an evaluative target volume (seroma + 5 mm), skin, breast, and ribs was evaluated to determine the impact of seed placement on the treatment. Results: The overall mean (±SD) difference between implanted and planned positions was 9 ± 5 mm for the aggregate seed population. No significant systematic directional displacements were observed for this whole population. However, for individual patients, systematic displacements were observed, implying that intrapatient offsets occur during the procedure. Mean displacements for seeds in the different anatomic areas were not found to be significantly different from the mean for the entire seed population. However, small directional trends were observed within the anatomy, potentially indicating some bias in the delivery. Despite observed differences between the planned and implanted seed positions, the median (range) V{sub 90} for the 20 patients was 97% (66%-100%), and acceptable dosimetry was achieved for critical structures. Conclusions: No significant trends or systematic errors were observed in the placement of seeds in PBSI, including seeds implanted directly into the seroma. Recorded seed displacements may be related to intrapatient setup adjustments. Despite observed seed displacements, acceptable postimplant dosimetry was achieved.« less

Final postflight hardware evaluation report RSRM-32 (STS-57)

NASA Technical Reports Server (NTRS)

Nielson, Greg

1993-01-01

This document is the final report for the postflight assessment of the RSRM-32 (STS-57) flight set. This report presents the disassembly evaluations performed at the Thiokol facilities in Utah and is a continuation of the evaluations performed at KSC (TWR-64239). The PEEP for this assessment is outlined in TWR-50051, Revision B. The PEEP defines the requirements for evaluating RSRM hardware. Special hardware issues pertaining to this flight set requiring additional or modified assessment are outlined in TWR-64237. All observed hardware conditions were documented on PFOR's which are included in Appendix A. Observations were compared against limits defined in the PEEP. Any observation that was categorized as reportable or had no defined limits was documented on a preliminary PFAR by the assessment engineers. Preliminary PFAR's were reviewed by the Thiokol SPAT Executive Board to determine if elevation to PFAR's was required.

Evaluating the Ocean Component of the US Navy Earth System Model

NASA Astrophysics Data System (ADS)

Zamudio, L.

2017-12-01

Ocean currents, temperature, and salinity observations are used to evaluate the ocean component of the US Navy Earth System Model. The ocean and atmosphere components of the system are an eddy-resolving (1/12.5° equatorial resolution) version of the HYbrid Coordinate Ocean Model (HYCOM), and a T359L50 version of the NAVy Global Environmental Model (NAVGEM), respectively. The system was integrated in hindcast mode and the ocean results are compared against unassimilated observations, a stand-alone version of HYCOM, and the Generalized Digital Environment Model ocean climatology. The different observation types used in the system evaluation are: drifting buoys, temperature profiles, salinity profiles, and acoustical proxies (mixed layer depth, sonic layer depth, below layer gradient, and acoustical trapping). To evaluate the system's performance in each different metric, a scorecard is used to translate the system's errors into scores, which provide an indication of the system's skill in both space and time.

Objective and automated protocols for the evaluation of biomedical search engines using No Title Evaluation protocols.

PubMed

Campagne, Fabien

2008-02-29

The evaluation of information retrieval techniques has traditionally relied on human judges to determine which documents are relevant to a query and which are not. This protocol is used in the Text Retrieval Evaluation Conference (TREC), organized annually for the past 15 years, to support the unbiased evaluation of novel information retrieval approaches. The TREC Genomics Track has recently been introduced to measure the performance of information retrieval for biomedical applications. We describe two protocols for evaluating biomedical information retrieval techniques without human relevance judgments. We call these protocols No Title Evaluation (NT Evaluation). The first protocol measures performance for focused searches, where only one relevant document exists for each query. The second protocol measures performance for queries expected to have potentially many relevant documents per query (high-recall searches). Both protocols take advantage of the clear separation of titles and abstracts found in Medline. We compare the performance obtained with these evaluation protocols to results obtained by reusing the relevance judgments produced in the 2004 and 2005 TREC Genomics Track and observe significant correlations between performance rankings generated by our approach and TREC. Spearman's correlation coefficients in the range of 0.79-0.92 are observed comparing bpref measured with NT Evaluation or with TREC evaluations. For comparison, coefficients in the range 0.86-0.94 can be observed when evaluating the same set of methods with data from two independent TREC Genomics Track evaluations. We discuss the advantages of NT Evaluation over the TRels and the data fusion evaluation protocols introduced recently. Our results suggest that the NT Evaluation protocols described here could be used to optimize some search engine parameters before human evaluation. Further research is needed to determine if NT Evaluation or variants of these protocols can fully substitute for human evaluations.

Evaluation of climatic changes in South-Asia

NASA Astrophysics Data System (ADS)

Kjellstrom, Erik; Rana, Arun; Grigory, Nikulin; Renate, Wilcke; Hansson, Ulf; Kolax, Michael

2016-04-01

Literature has sufficient evidences of climate change impact all over the world and its impact on various sectors. In light of new advancements made in climate modeling, availability of several climate downscaling approaches, the more robust bias correction methods with varying complexities and strengths, in the present study we performed a systematic evaluation of climate change impact over South-Asia region. We have used different Regional Climate Models (RCMs) (from CORDEX domain), (Global Climate Models GCMs) and gridded observations for the study area to evaluate the models in historical/control period (1980-2010) and changes in future period (2010-2099). Firstly, GCMs and RCMs are evaluated against the Gridded observational datasets in the area using precipitation and temperature as indicative variables. Observational dataset are also evaluated against the reliable set of observational dataset, as pointed in literature. Bias, Correlation, and changes (among other statistical measures) are calculated for the entire region and both the variables. Eventually, the region was sub-divided into various smaller domains based on homogenous precipitation zones to evaluate the average changes over time period. Spatial and temporal changes for the region are then finally calculated to evaluate the future changes in the region. Future changes are calculated for 2 Representative Concentration Pathways (RCPs), the middle emission (RCP4.5) and high emission (RCP8.5) and for both climatic variables, precipitation and temperature. Lastly, Evaluation of Extremes is performed based on precipitation and temperature based indices for whole region in future dataset. Results have indicated that the whole study region is under extreme stress in future climate scenarios for both climatic variables i.e. precipitation and temperature. Precipitation variability is dependent on the location in the area leading to droughts and floods in various regions in future. Temperature is hinting towards a constant increase throughout the region regardless of location.

The Role of Scheduling in Observing Teacher-Child Interactions

ERIC Educational Resources Information Center

Cash, Anne H.; Pianta, Robert C.

2014-01-01

Observational assessment is being used on a large scale to evaluate the quality of interactions between teachers and children in classroom environments. When one performs observations at scale, features of the protocol such as the scheduling of observations can potentially influence observed scores. In this study interactions were observed for 88…

Constraining the uncertainty in emissions over India with a regional air quality model evaluation

NASA Astrophysics Data System (ADS)

Karambelas, Alexandra; Holloway, Tracey; Kiesewetter, Gregor; Heyes, Chris

2018-02-01

To evaluate uncertainty in the spatial distribution of air emissions over India, we compare satellite and surface observations with simulations from the U.S. Environmental Protection Agency (EPA) Community Multi-Scale Air Quality (CMAQ) model. Seasonally representative simulations were completed for January, April, July, and October 2010 at 36 km × 36 km using anthropogenic emissions from the Greenhouse Gas-Air Pollution Interaction and Synergies (GAINS) model following version 5a of the Evaluating the Climate and Air Quality Impacts of Short-Lived Pollutants project (ECLIPSE v5a). We use both tropospheric columns from the Ozone Monitoring Instrument (OMI) and surface observations from the Central Pollution Control Board (CPCB) to closely examine modeled nitrogen dioxide (NO2) biases in urban and rural regions across India. Spatial average evaluation with satellite retrievals indicate a low bias in the modeled tropospheric column (-63.3%), which reflects broad low-biases in majority non-urban regions (-70.1% in rural areas) across the sub-continent to slightly lesser low biases reflected in semi-urban areas (-44.7%), with the threshold between semi-urban and rural defined as 400 people per km2. In contrast, modeled surface NO2 concentrations exhibit a slight high bias of +15.6% when compared to surface CPCB observations predominantly located in urban areas. Conversely, in examining extremely population dense urban regions with more than 5000 people per km2 (dense-urban), we find model overestimates in both the column (+57.8) and at the surface (+131.2%) compared to observations. Based on these results, we find that existing emission fields for India may overestimate urban emissions in densely populated regions and underestimate rural emissions. However, if we rely on model evaluation with predominantly urban surface observations from the CPCB, comparisons reflect model high biases, contradictory to the knowledge gained using satellite observations. Satellites thus serve as an important emissions and model evaluation metric where surface observations are lacking, such as rural India, and support improved emissions inventory development.

Evaluating Usability of Radiology Information Systems in Hospitals of Tabriz University of Medical Sciences.

PubMed

Rezaei-Hachesu, Peyman; Pesianian, Esmaeil; Mohammadian, Mohsen

2016-02-01

Radiology information system (RIS) in order to reduce workload and improve the quality of services must be well-designed. Heuristic evaluation is one of the methods that understand usability problems with the least time, cost and resources. The aim of present study is to evaluate the usability of RISs in hospitals. This is a cross-sectional descriptive study (2015) that uses heuristic evaluation method to evaluate the usability of RIS used in 3 hospitals of Tabriz city. The data are collected using a standard checklist based on 13 principles of Nielsen Heuristic evaluation method. Usability of RISs was investigated based on the number of components observed from Nielsen principles and problems of usability based on the number of non-observed components as well as non-existent or unrecognizable components. by evaluation of RISs in each of the hospitals 1, 2 and 3, total numbers of observed components were obtained as 173, 202 and 196, respectively. It was concluded that the usability of RISs in the studied population, on average and with observing 190 components of the 291 components related to the 13 principles of Nielsen is 65.41 %. Furthermore, problems of usability were obtained as 26.35%. The established and visible nature of some components such as response time of application, visual feedbacks, colors, view and design and arrangement of software objects cause more attention to these components as principal components in designing UI software. Also, incorrect analysis before system design leads to a lack of attention to secondary needs like Help software and security issues.

Work organization in hospital wards and nurses' emotional exhaustion: A multi-method study of observation-based assessment and nurses' self-reports.

PubMed

Stab, Nicole; Hacker, Winfried; Weigl, Matthias

2016-09-01

Ward organization is a major determinant for nurses' well-being on the job. The majority of previous research on this relationship is based on single source methods, which have been criticized as skewed estimations mainly due to subjectivity of the ratings and due to common source bias. To investigate the association of ward organization characteristics and nurses' exhaustion by combining observation-based assessments with nurses' self-reports. Cross-sectional study on 25 wards of four hospitals and 245 nurses. Our multi-method approach to evaluate hospital ward organization consisted of on-site observations with a standardized assessment tool and of questionnaires to evaluate nurses' self-reports and exhaustion. After establishing the reliability of our measures, we applied multi-level regression analyses to determine associations between determinant and outcome variables. We found substantial convergence in ward organization between the observation-based assessments and nurses' self-reports, which supports the validity of our external assessments. Furthermore, two observation-based characteristics, namely participation and patient-focused care, were significantly associated with lower emotional exhaustion among the nurses. Our results suggest that observation-based assessments are a valid and feasible way to assess ward organization in hospitals. Nurses' self-reported as well as observation-based ratings on ward organization were associated with nurses' emotional exhaustion. This is of interest mainly for identifying alternative measures in evaluating nurses' work environments, to inform health promotion activities and to evaluate job redesign intervention. Copyright © 2016 Elsevier Ltd. All rights reserved.

Evaluating a Priori Ozone Profile Information Used in TEMPO (Tropospheric Emissions: Monitoring of Pollution) Tropospheric Ozone Retrievals

NASA Technical Reports Server (NTRS)

Johnson, Matthew Stephen

2017-01-01

A primary objective for TOLNet is the evaluation and validation of space-based tropospheric O3 retrievals from future systems such as the Tropospheric Emissions: Monitoring of Pollution (TEMPO) satellite. This study is designed to evaluate the tropopause-based O3 climatology (TB-Clim) dataset which will be used as the a priori profile information in TEMPO O3 retrievals. This study also evaluates model simulated O3 profiles, which could potentially serve as a priori O3 profile information in TEMPO retrievals, from near-real-time (NRT) data assimilation model products (NASA Global Modeling and Assimilation Office (GMAO) Goddard Earth Observing System (GEOS-5) Forward Processing (FP) and Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA2)) and full chemical transport model (CTM), GEOS-Chem, simulations. The TB-Clim dataset and model products are evaluated with surface (0-2 km) and tropospheric (0-10 km) TOLNet observations to demonstrate the accuracy of the suggested a priori dataset and information which could potentially be used in TEMPO O3 algorithms. This study also presents the impact of individual a priori profile sources on the accuracy of theoretical TEMPO O3 retrievals in the troposphere and at the surface. Preliminary results indicate that while the TB-Clim climatological dataset can replicate seasonally-averaged tropospheric O3 profiles observed by TOLNet, model-simulated profiles from a full CTM (GEOS-Chem is used as a proxy for CTM O3 predictions) resulted in more accurate tropospheric and surface-level O3 retrievals from TEMPO when compared to hourly (diurnal cycle evaluation) and daily-averaged (daily variability evaluation) TOLNet observations. Furthermore, it was determined that when large daily-averaged surface O3 mixing ratios are observed (65 ppb), which are important for air quality purposes, TEMPO retrieval values at the surface display higher correlations and less bias when applying CTM a priori profile information compared to all other data products. The primary reason for this is that CTM predictions better capture the spatio-temporal variability of the vertical profiles of observed tropospheric O3 compared to the TB-Clim dataset and other NRT data assimilation models evaluated during this study.

Compatibility of pedigree-based and marker-based relationship matrices for single-step genetic evaluation.

PubMed

Christensen, Ole F

2012-12-03

Single-step methods provide a coherent and conceptually simple approach to incorporate genomic information into genetic evaluations. An issue with single-step methods is compatibility between the marker-based relationship matrix for genotyped animals and the pedigree-based relationship matrix. Therefore, it is necessary to adjust the marker-based relationship matrix to the pedigree-based relationship matrix. Moreover, with data from routine evaluations, this adjustment should in principle be based on both observed marker genotypes and observed phenotypes, but until now this has been overlooked. In this paper, I propose a new method to address this issue by 1) adjusting the pedigree-based relationship matrix to be compatible with the marker-based relationship matrix instead of the reverse and 2) extending the single-step genetic evaluation using a joint likelihood of observed phenotypes and observed marker genotypes. The performance of this method is then evaluated using two simulated datasets. The method derived here is a single-step method in which the marker-based relationship matrix is constructed assuming all allele frequencies equal to 0.5 and the pedigree-based relationship matrix is constructed using the unusual assumption that animals in the base population are related and inbred with a relationship coefficient γ and an inbreeding coefficient γ / 2. Taken together, this γ parameter and a parameter that scales the marker-based relationship matrix can handle the issue of compatibility between marker-based and pedigree-based relationship matrices. The full log-likelihood function used for parameter inference contains two terms. The first term is the REML-log-likelihood for the phenotypes conditional on the observed marker genotypes, whereas the second term is the log-likelihood for the observed marker genotypes. Analyses of the two simulated datasets with this new method showed that 1) the parameters involved in adjusting marker-based and pedigree-based relationship matrices can depend on both observed phenotypes and observed marker genotypes and 2) a strong association between these two parameters exists. Finally, this method performed at least as well as a method based on adjusting the marker-based relationship matrix. Using the full log-likelihood and adjusting the pedigree-based relationship matrix to be compatible with the marker-based relationship matrix provides a new and interesting approach to handle the issue of compatibility between the two matrices in single-step genetic evaluation.

Teacher Observation: Evaluation Report and Executive Summary

ERIC Educational Resources Information Center

Worth, Jack; Sizmur, Juliet; Walker, Matthew; Bradshaw, Sally; Styles, Ben

2017-01-01

The Teacher Observation intervention aimed to improve teacher effectiveness through structured peer observation. Teachers observe and are observed by their peers a number of times over the course of two years. It was delivered by the Centre for Market and Public Organisation (CMPO) at the University of Bristol. CMPO researchers trained lead…

Video Modeling and Observational Learning to Teach Gaming Access to Students with ASD

ERIC Educational Resources Information Center

Spriggs, Amy D.; Gast, David L.; Knight, Victoria F.

2016-01-01

The purpose of this study was to evaluate both video modeling and observational learning to teach age-appropriate recreation and leisure skills (i.e., accessing video games) to students with autism spectrum disorder. Effects of video modeling were evaluated via a multiple probe design across participants and criteria for mastery were based on…

Developing Essay Writing Skills: An Evaluation of the Modelling Behaviour Method and the Influence of Student Self-Efficacy

ERIC Educational Resources Information Center

Callinan, Carol J.; van der Zee, Emile; Wilson, Garry

2018-01-01

Social cognitive learning theory has shown that observational learning positively influences essay writing development in high-school students, and that self-efficacy impacts on motivation. This study investigated the relative contribution of model observation, model evaluation, post-submission feedback, and factors relating to self-efficacy, as…

Video-Based Self-Observation as a Component of Developmental Teacher Evaluation

ERIC Educational Resources Information Center

Mercado, Leonardo A.; Baecher, Laura

2014-01-01

In this paper, we explore the benefits to teacher evaluation when video-based self-observation is done by teachers as a vehicle for individual, reflective practice. We explore how it was applied systematically at the ICPNA bi-national center among hundreds of EFL teachers within two institution-wide initiatives that have relied on self-observation…

Can We Identify a Successful Teacher Better, Faster, and Cheaper? Evidence for Innovating Teacher Observation Systems

ERIC Educational Resources Information Center

Gargani, John; Strong, Michael

2014-01-01

Teacher observations have become a national education phenomenon, mandated by federal policies and promoted by philanthropists. They are crucial components of teacher evaluation systems that often have high stakes for teachers and school systems, but have sparked little innovation. Recent calls to make teacher evaluations better, faster, and…

An Evaluation of the Effectiveness of an Automated Observation and Feedback System on Safe Sitting Postures

ERIC Educational Resources Information Center

Yu, Eunjeong; Moon, Kwangsu; Oah, Shezeen; Lee, Yohaeng

2013-01-01

This study evaluated the effectiveness of an automated observation and feedback system in improving safe sitting postures. Participants were four office workers. The dependent variables were the percentages of time participants spent in five safe body positions during experimental sessions. We used a multiple-baseline design counterbalanced across…

An Overview of Atmospheric Chemistry and Air Quality Modeling

NASA Technical Reports Server (NTRS)

Johnson, Matthew S.

2017-01-01

This presentation will include my personal research experience and an overview of atmospheric chemistry and air quality modeling to the participants of the NASA Student Airborne Research Program (SARP 2017). The presentation will also provide examples on ways to apply airborne observations for chemical transport (CTM) and air quality (AQ) model evaluation. CTM and AQ models are important tools in understanding tropospheric-stratospheric composition, atmospheric chemistry processes, meteorology, and air quality. This presentation will focus on how NASA scientist currently apply CTM and AQ models to better understand these topics. Finally, the importance of airborne observation in evaluating these topics and how in situ and remote sensing observations can be used to evaluate and improve CTM and AQ model predictions will be highlighted.

Angiographic assessment of initial balloon angioplasty results.

PubMed

Gardiner, Geoffrey A; Sullivan, Kevin L; Halpern, Ethan J; Parker, Laurence; Beck, Margaret; Bonn, Joseph; Levin, David C

2004-10-01

To determine the influence of three factors involved in the angiographic assessment of balloon angioplasty-interobserver variability, operator bias, and the definition used to determine success-on the primary (technical) results of angioplasty in the peripheral arteries. Percent stenosis in 107 lesions in lower-extremity arteries was graded by three independent, experienced vascular radiologists ("observers") before and after balloon angioplasty and their estimates were compared with the initial interpretations reported by the physician performing the procedure ("operator") and an automated quantitative computer analysis. Observer variability was measured with use of intraclass correlation coefficients and SD. Differences among the operator, observers, and the computer were analyzed with use of the Wilcoxon signed-rank test and analysis of variance. For each evaluator, the results in this series of lesions were interpreted with three different definitions of success. Estimation of residual stenosis varied by an average range of 22.76% with an average SD of 8.99. The intraclass correlation coefficients averaged 0.59 for residual stenosis after angioplasty for the three observers but decreased to 0.36 when the operator was included as the fourth evaluator. There was good to very good agreement among the three independent observers and the computer, but poor correlation with the operator (P

Do health economic evaluations using observational data provide reliable assessment of treatment effects?

PubMed Central

2013-01-01

Economic evaluation in modern health care systems is seen as a transparent scientific framework that can be used to advance progress towards improvements in population health at the best possible value. Despite the perceived superiority that trial-based studies have in terms of internal validity, economic evaluations often employ observational data. In this review, the interface between econometrics and economic evaluation is explored, with emphasis placed on highlighting methodological issues relating to the evaluation of cost-effectiveness within a bivariate framework. Studies that satisfied the eligibility criteria exemplified the use of matching, regression analysis, propensity scores, instrumental variables, as well as difference-in-differences approaches. All studies were reviewed and critically appraised using a structured template. The findings suggest that although state-of-the-art econometric methods have the potential to provide evidence on the causal effects of clinical and policy interventions, their application in economic evaluation is subject to a number of limitations. These range from no credible assessment of key assumptions and scarce evidence regarding the relative performance of different methods, to lack of reporting of important study elements, such as a summary outcome measure and its associated sampling uncertainty. Further research is required to better understand the ways in which observational data should be analysed in the context of the economic evaluation framework. PMID:24229445

Evaluation of radiographic interpretation competence of veterinary students in Finland.

PubMed

Koskinen, Heli I; Snellman, Marjatta

2009-01-01

In the evaluation of the clinical competence of veterinary students, many different definitions and methods are approved. Due to the increasing discussion of the quality of outcomes produced by newly graduated veterinarians, methods for the evaluation of clinical competencies should also be evaluated. In this study, this was done by comparing two qualitative evaluation schemes: the well-known structure of observed learning outcome (SOLO) taxonomy and a modification of this taxonomy. A case-based final radiologic examination was selected and the investigation was performed by classifying students' outcomes. These classes were finally put next to original (quantitative) scores and the statistical calculations were initiated. Significant correlations between taxonomies (0.53) and the modified taxonomy and original scores (0.66) were found and some qualitative similarities between evaluation methods were observed. In addition, some supplements were recommended for the structure of evaluation schemes, especially for the structure of the modified SOLO taxonomy.

Three-dimensional ultrasonography of the breast; An adequate replacement for MRI in neoadjuvant chemotherapy tumour response evaluation? - RESPONDER trial.

PubMed

van Egdom, L S E; Lagendijk, M; Heijkoop, E H M; Koning, A H J; van Deurzen, C H M; Jager, A; van Lankeren, W; Koppert, L B

2018-07-01

Accurate measurement of tumour response during and after neoadjuvant chemotherapy (NAC) is important and may influence treatment decisions in invasive breast cancer patients. Breast MRI forms the gold standard but is more burdensome, time consuming and costly. In this study response measurement was done with 3-D ultrasound by Automated Breast Volume Scanner (ABVS) and compared to breast MRI. Moreover, patient satisfaction with both techniques was compared. A single-institution, prospective observational pilot study evaluating tumour response by ABVS in addition to breast MRI (standard care) was performed in 25 invasive breast cancer patients receiving NAC. Tumour response was evaluated comparing longest tumour diameters as well as tumour volumes at predefined time points using Bland-Altman analysis. Volume measurements for breast MRI were obtained using a fully immersive virtual reality system (a Barco I-Space) and V-Scope software. Same software was used to obtain ABVS volume measurements using an in-house developed desktop VR system. Inter- and intra-observer agreement was evaluated by Intraclass Correlation Coefficient (ICC). Twenty-five patients were eligible for baseline measurement, 20 for a mid-NAC response evaluation, and five for a post-NAC response evaluation. MRI and ABVS showed absolute concordance in 73% of patients for the mid-NAC evaluation, with a 'good' correlation for the difference in longest diameter measurement (ICC 0.73, p < 0.01) as compared to baseline assessment. Concerning difference in volume measurement in the mid-NAC response evaluation showed a 'fair' correlation (ICC 0.52, p < 0.01) and in the post-NAC response evaluation an 'excellent' correlation (ICC 0.98, p < 0.01). 'Excellent' inter- and intra-observer agreement was found (ICC 0.88, p < 0.01) with comparable limits of agreement (LOA) for observer 1 and 2 in both diameter and volume measurement. Patient satisfaction was higher for ABVS compared to breast MRI, 93% versus 12% respectively. ABVS showed 'good' correlation with MRI tumour response evaluation in breast cancer patients during NAC with 'excellent' inter- and intra-observer agreement. ABVS has patients' preference over breast MRI and could be considered as alternative to breast MRI, in case results on an on-going prospective trial confirm these results (NTR6799). Copyright © 2018 Elsevier B.V. All rights reserved.

OSSE Evaluation of Aircraft Reconnaissance Observations and their Impact on Hurricane Analyses and Forecasts

NASA Astrophysics Data System (ADS)

Ryan, K. E.; Bucci, L. R.; Delgado, J.; Atlas, R. M.; Murillo, S.; Dodge, P.

2016-12-01

NOAA/AOML's Hurricane Research Division (HRD) annually conducts its Hurricane Field Program during which observations are collected via NOAA aircraft to improve the understanding and prediction of hurricanes. Mission experiments suggest a variety of flight patterns and sampling strategies aimed towards their respective goals described by the Intensity Forecasting Experiment (IFEX; Rogers et al., BAMS, 2006, 2013), a collaborative effort among HRD, NHC, and EMC. Evaluating the potential impact of various trade-offs in track design is valuable for determining the optimal air reconnaissance flight pattern for a prospective mission. AOML's HRD has developed a system for performing regional Observing System Simulation Experiments (OSSEs) to assess the potential impact of proposed observing systems on hurricane track and intensity forecasts and analyses. This study focuses on investigating the potential impact of proposed aircraft reconnaissance observing system designs. Aircraft instrument and flight level retrievals were simulated from a regional WRF ARW Nature Run (Nolan et al., 2013) spanning 13 days, covering the life cycle of a rapidly intensifying Atlantic tropical cyclone. The aircraft trajectories of NOAA aircraft are simulated in a variety of ways and are evaluated to examine the potential impact of aircraft reconnaissance observations on hurricane track and intensity forecasts.

Influences of observer sex, facial masculinity, and gender role identification on first impressions of men’s faces

PubMed Central

Macapagal, Kathryn R.; Rupp, Heather A.; Heiman, Julia R.

2011-01-01

Evaluations of male faces depend on attributes of the observer and target and may influence future social and sexual decisions. However, it is unknown whether adherence to hypertraditional gender roles may shape women’s evaluations of potential sexual partners or men’s evaluations of potential competitors. Using a photo task, we tested participants’ judgments of attractiveness, trustworthiness, aggressiveness, and masculinity of male faces altered to appear more masculine or feminine. Findings revealed that higher hypermasculinity scores in male observers were correlated with higher attractiveness and trustworthiness ratings of the male faces; conversely, higher hyperfemininity scores in female observers were associated with lower ratings on those traits. Male observers also rated the faces as more aggressive than did female observers. Regarding ratings by face type, masculinized faces were rated more aggressive than feminized faces, and women’s ratings did not discriminate between altered faces better than men’s ratings. These results suggest that first impressions of men can be explained in part by socioculturally- and evolutionarily-relevant factors such as the observer’s sex and gender role adherence, as well as the target’s facial masculinity. PMID:21874151

Lesion detection performance of cone beam CT images with anatomical background noise: single-slice vs. multi-slice human and model observer study

NASA Astrophysics Data System (ADS)

Han, Minah; Jang, Hanjoo; Baek, Jongduk

2018-03-01

We investigate lesion detectability and its trends for different noise structures in single-slice and multislice CBCT images with anatomical background noise. Anatomical background noise is modeled using a power law spectrum of breast anatomy. Spherical signal with a 2 mm diameter is used for modeling a lesion. CT projection data are acquired by the forward projection and reconstructed by the Feldkamp-Davis-Kress algorithm. To generate different noise structures, two types of reconstruction filters (Hanning and Ram-Lak weighted ramp filters) are used in the reconstruction, and the transverse and longitudinal planes of reconstructed volume are used for detectability evaluation. To evaluate single-slice images, the central slice, which contains the maximum signal energy, is used. To evaluate multislice images, central nine slices are used. Detectability is evaluated using human and model observer studies. For model observer, channelized Hotelling observer (CHO) with dense difference-of-Gaussian (D-DOG) channels are used. For all noise structures, detectability by a human observer is higher for multislice images than single-slice images, and the degree of detectability increase in multislice images depends on the noise structure. Variation in detectability for different noise structures is reduced in multislice images, but detectability trends are not much different between single-slice and multislice images. The CHO with D-DOG channels predicts detectability by a human observer well for both single-slice and multislice images.

Evaluation Procedures in the Charlotte-Mecklenburg Career Ladder Plan.

ERIC Educational Resources Information Center

Schlechty, Phillip C.

1985-01-01

Describes faculty evaluation procedures used in the Charlotte-Mecklenburg (North Carolina) Public Schools in conjunction with career development. Covers the program's philosophy, purposes, and special characteristics; expectations set and competencies sought; the areas evaluation; evaluator characteristics; the observation process; teachers'…

Evaluation of horizontal curve design

DOT National Transportation Integrated Search

1980-08-01

This report documents an initial evaluation of horizontal curve design criteria which involved two phases: an observational study and an analytical evaluation. Three classes of vehicles (automobiles, school buses and tractor semi-trailers) and three ...

Values of a Patient and Observer Scar Assessment Scale to Evaluate the Facial Skin Graft Scar

PubMed Central

Chae, Jin Kyung; Kim, Eun Jung; Park, Kun

2016-01-01

Background The patient and observer scar assessment scale (POSAS) recently emerged as a promising method, reflecting both observer's and patient's opinions in evaluating scar. This tool was shown to be consistent and reliable in burn scar assessment, but it has not been tested in the setting of skin graft scar in skin cancer patients. Objective To evaluate facial skin graft scar applied to POSAS and to compare with objective scar assessment tools. Methods Twenty three patients, who diagnosed with facial cutaneous malignancy and transplanted skin after Mohs micrographic surgery, were recruited. Observer assessment was performed by three independent rates using the observer component of the POSAS and Vancouver scar scale (VSS). Patient self-assessment was performed using the patient component of the POSAS. To quantify scar color and scar thickness more objectively, spectrophotometer and ultrasonography was applied. Results Inter-observer reliability was substantial with both VSS and the observer component of the POSAS (average measure intraclass coefficient correlation, 0.76 and 0.80, respectively). The observer component consistently showed significant correlations with patients' ratings for the parameters of the POSAS (all p-values<0.05). The correlation between subjective assessment using POSAS and objective assessment using spectrophotometer and ultrasonography showed low relationship. Conclusion In facial skin graft scar assessment in skin cancer patients, the POSAS showed acceptable inter-observer reliability. This tool was more comprehensive and had higher correlation with patient's opinion. PMID:27746642

Inter-rater reliability of direct observations of the physical and psychosocial working conditions in eldercare: An evaluation in the DOSES project.

PubMed

Karstad, Kristina; Rugulies, Reiner; Skotte, Jørgen; Munch, Pernille Kold; Greiner, Birgit A; Burdorf, Alex; Søgaard, Karen; Holtermann, Andreas

2018-05-01

The aim of the study was to develop and evaluate the reliability of the "Danish observational study of eldercare work and musculoskeletal disorders" (DOSES) observation instrument to assess physical and psychosocial risk factors for musculoskeletal disorders (MSD) in eldercare work. During 1.5 years, sixteen raters conducted 117 inter-rater observations from 11 nursing homes. Reliability was evaluated using percent agreement and Gwet's AC1 coefficient. Of the 18 examined items, inter-rater reliability was excellent for 7 items (AC1>0.75) fair to good for 7 items (AC1 0.40-0.75) and poor for 2 items (AC1 0-0.40). For 2 items there was no agreement between the raters (AC1 <0). The reliability did not differ between the first and second half of the data collection period and the inter-rater observations were representative regarding occurrence of events in eldercare work. The instrument is appropriate for assessing physical and psychosocial risk factors for MSD among eldercare workers. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Watch what happens: using a web-based multimedia platform to enhance intraoperative learning and development of clinical reasoning.

PubMed

Fingeret, Abbey L; Martinez, Rebecca H; Hsieh, Christine; Downey, Peter; Nowygrod, Roman

2016-02-01

We aim to determine whether observed operations or internet-based video review predict improved performance in the surgery clerkship. A retrospective review of students' usage of surgical videos, observed operations, evaluations, and examination scores were used to construct an exploratory principal component analysis. Multivariate regression was used to determine factors predictive of clerkship performance. Case log data for 231 students revealed a median of 25 observed cases. Students accessed the web-based video platform a median of 15 times. Principal component analysis yielded 4 factors contributing 74% of the variability with a Kaiser-Meyer-Olkin coefficient of .83. Multivariate regression predicted shelf score (P < .0001), internal clinical skills examination score (P < .0001), subjective evaluations (P < .001), and video website utilization (P < .001) but not observed cases to be significantly associated with overall performance. Utilization of a web-based operative video platform during a surgical clerkship is an independently associated with improved clinical reasoning, fund of knowledge, and overall evaluation. Thus, this modality can serve as a useful adjunct to live observation. Copyright © 2016 Elsevier Inc. All rights reserved.

Inter and intra-observer concordance for the diagnosis of portal hypertension gastropathy.

PubMed

Casas, Meritxell; Vergara, Mercedes; Brullet, Enric; Junquera, Félix; Martínez-Bauer, Eva; Miquel, Mireia; Sánchez-Delgado, Jordi; Dalmau, Blai; Campo, Rafael; Calvet, Xavier

2018-03-01

At present there is no fully accepted endoscopic classification for the assessment of the severity of portal hypertensive gastropathy (PHG). Few studies have evaluated inter and intra-observer concordance or the degree of concordance between different endoscopic classifications. To evaluate inter and intra-observer agreement for the presence of portal hypertensive gastropathy and enteropathy using different endoscopic classifications. Patients with liver cirrhosis were included into the study. Enteroscopy was performed under sedation. The location of lesions and their severity was recorded. Images were videotaped and subsequently evaluated independently by three different endoscopists, one of whom was the initial endoscopist. The agreement between observations was assessed using the kappa index. Seventy-four patients (mean age 63.2 years, 53 males and 21 females) were included. The agreement between the three endoscopists regarding the presence or absence of PHG using the Tanoue and McCormack classifications was very low (kappa scores = 0.16 and 0.27, respectively). The current classifications of portal hypertensive gastropathy have a very low degree of intra and inter-observer agreement for the diagnosis and assessment of gastropathy severity.

[Reconsidering evaluation criteria regarding health care research: toward an integrative framework of quantitative and qualitative criteria].

PubMed

Miyata, Hiroaki; Kai, Ichiro

2006-05-01

Debate about the relationship between quantitative and qualitative paradigms is often muddled and confused and the clutter of terms and arguments has resulted in the concepts becoming obscure and unrecognizable. It is therefore very important to reconsider evaluation criteria regarding rigor in social science. As Lincoln & Guba have already compared quantitative paradigms (validity, reliability, neutrality, generalizability) with qualitative paradigms (credibility, dependability, confirmability, transferability), we have discuss use of evaluation criteria based on pragmatic perspective. Validity/Credibility is the paradigm concerned to observational framework, while Reliability/Dependability refer to the range of stability in observations, Neutrality/Confirmability reflect influences between observers and subjects, Generalizability/Transferability have epistemological difference in the way findings are applied. Qualitative studies, however, does not always chose the qualitative paradigms. If we assume the stability to some extent, it is better to use the quantitative paradigm (reliability). Moreover as a quantitative study can not always guarantee a perfect observational framework, with stability in all phases of observations, it is useful to use qualitative paradigms to enhance the rigor in the study.

Dynamic evaluation of two decades of WRF-CMAQ ozone simulations over the contiguous United States

NASA Astrophysics Data System (ADS)

Astitha, Marina; Luo, Huiying; Rao, S. Trivikrama; Hogrefe, Christian; Mathur, Rohit; Kumar, Naresh

2017-09-01

Dynamic evaluation of the fully coupled Weather Research and Forecasting (WRF)- Community Multi-scale Air Quality (CMAQ) model ozone simulations over the contiguous United States (CONUS) using two decades of simulations covering the period from 1990 to 2010 is conducted to assess how well the changes in observed ozone air quality are simulated by the model. The changes induced by variations in meteorology and/or emissions are also evaluated during the same timeframe using spectral decomposition of observed and modeled ozone time series with the aim of identifying the underlying forcing mechanisms that control ozone exceedances and making informed recommendations for the optimal use of regional-scale air quality models. The evaluation is focused on the warm season's (i.e., May-September) daily maximum 8-hr (DM8HR) ozone concentrations, the 4th highest (4th) and average of top 10 DM8HR ozone values (top10), as well as the spectrally-decomposed components of the DM8HR ozone time series using the Kolmogorov-Zurbenko (KZ) filter. Results of the dynamic evaluation are presented for six regions in the U.S., consistent with the National Oceanic and Atmospheric Administration (NOAA) climatic regions. During the earlier 11-yr period (1990-2000), the simulated and observed regional average trends are not statistically significant. During the more recent 2000-2010 period, all observed trends are statistically significant and WRF-CMAQ captures the observed downward trend in the Southwest and Midwest but under-predicts the downward trends in observations for the other regions. Observational analysis reveals that it is the magnitude of the long-term forcing that dictates the maximum ozone exceedance potential; there is a strong linear relationship between the long-term forcing and the 4th highest or the average of the top10 ozone concentrations in both observations and model output. This finding indicates that improving the model's ability to reproduce the long-term component will also enable better simulation of ozone extreme values that are of interest to regulatory agencies.

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System.

PubMed

Langner, Marini; Machado, Rodrigo Strehl; Patrício, Francy R S; Kawakami, Elisabete

2009-01-01

Although Helicobacter pylori infection is prevalent in our country, there are few studies evaluating the associated histological abnormalities in children. To evaluate the histological features of the gastric mucosa in children and adolescents with Helicobacter pylori gastritis. One hundred and thirty two gastric biopsies from 22 symptomatic patients infected with H. pylori (14F/8M, median age 10 y 5 mo, age range 2 y 11 mo to 16 y 9 mo) were evaluated. Evaluated gastric regions included: antrum (lesser and greater curvature), corpus (lesser and greater curvature), incisura angularis and fundus. Histological examination was performed according to the Updated Sydney System, and regional scores for polymorphonuclear and mononuclear cell infiltrate as well as bacterial density were generated. Fifteen (68.2%) patients presented H. pylori-chronic active gastritis, six (27.3%) presented antrum-predominant H. pylori-chronic active gastritis, and one (4.5%) presented corpus-predominant H. pylori-chronic active gastritis. Polymorphonuclear cell infiltrate and mononuclear cell infiltrate were observed in 93.9% and 98.5% of the biopsy specimens, respectively. Higher histological scores for polymorphonuclear infiltrate, mononuclear infiltrate, and bacterial density were observed in the gastric antrum. Intestinal metaplasia and gastric atrophy were not identified in any patient. Lymphoid aggregates and lymphoid follicles were observed in the gastric antrum of three (13.6%) and seven (31.8%) patients, respectively, but they were not related to antral nodularity. Chronic active gastritis was observed in all patients with H. pylori infection. However, antral or corporeal predominance was not observed in most patients.

Evaluation of Surface Flux Parameterizations with Long-Term ARM Observations

DOE PAGES

Liu, Gang; Liu, Yangang; Endo, Satoshi

2013-02-01

Surface momentum, sensible heat, and latent heat fluxes are critical for atmospheric processes such as clouds and precipitation, and are parameterized in a variety of models ranging from cloud-resolving models to large-scale weather and climate models. However, direct evaluation of the parameterization schemes for these surface fluxes is rare due to limited observations. This study takes advantage of the long-term observations of surface fluxes collected at the Southern Great Plains site by the Department of Energy Atmospheric Radiation Measurement program to evaluate the six surface flux parameterization schemes commonly used in the Weather Research and Forecasting (WRF) model and threemore » U.S. general circulation models (GCMs). The unprecedented 7-yr-long measurements by the eddy correlation (EC) and energy balance Bowen ratio (EBBR) methods permit statistical evaluation of all six parameterizations under a variety of stability conditions, diurnal cycles, and seasonal variations. The statistical analyses show that the momentum flux parameterization agrees best with the EC observations, followed by latent heat flux, sensible heat flux, and evaporation ratio/Bowen ratio. The overall performance of the parameterizations depends on atmospheric stability, being best under neutral stratification and deteriorating toward both more stable and more unstable conditions. Further diagnostic analysis reveals that in addition to the parameterization schemes themselves, the discrepancies between observed and parameterized sensible and latent heat fluxes may stem from inadequate use of input variables such as surface temperature, moisture availability, and roughness length. The results demonstrate the need for improving the land surface models and measurements of surface properties, which would permit the evaluation of full land surface models.« less

Effects of the Non-Nutritive Sweeteners on Glucose Metabolism and Appetite Regulating Hormones: Systematic Review of Observational Prospective Studies and Clinical Trials

PubMed Central

Romo-Romo, Alonso; Aguilar-Salinas, Carlos A.; Brito-Córdova, Griselda X.; Gómez Díaz, Rita A.; Vilchis Valentín, David

2016-01-01

Background The effects of non-nutritive sweeteners (NNS) on glucose metabolism and appetite regulating hormones are not clear. There is an ongoing debate concerning NNS use and deleterious changes in metabolism. Objectives The aim of this review is to analyze the scientific available evidence regarding the effects of NNS on glucose metabolism and appetite regulating hormones. Data Sources and Study Eligibility Criteria We identified human observational studies evaluating the relation between NNS consumption and obesity, diabetes, and metabolic syndrome, in addition to clinical trials evaluating the effects of NNS in glucose metabolism and appetite regulating hormones. Results Fourteen observational studies evaluating the association between NNS consumption and the development of metabolic diseases and twenty-eight clinical trials studying the effects of NNS on metabolism were included. Finally, two meta-analyses evaluating the association between the consumption of NNS-containing beverages and the development of type 2 diabetes were identified. Conclusions Some observational studies suggest an association between NNS consumption and development of metabolic diseases; however, adiposity is a confounder frequently found in observational studies. The effects of the NNS on glucose metabolism are not clear. The results of the identified clinical trials are contradictory and are not comparable because of the major existing differences between them. Studies evaluating specific NNS, with an adequate sample size, including a homogeneous study group, identifying significant comorbidities, with an appropriate control group, with an appropriate exposure time, and considering adjustment for confounder variables such as adiposity are needed. PMID:27537496

Evaluators' Decision Making: The Relationship between Theory, Practice, and Experience

ERIC Educational Resources Information Center

Tourmen, Claire

2009-01-01

How do evaluation practitioners make choices when they evaluate a program? What function do evaluation theories play in practice? In this article, I report on an exploratory study that examined evaluation practices in France. The research began with observations of practitioners' activities, with a particular focus on the phases of evaluation…

The Effects of Two Different Management Styles on Internal Evaluation or Boss and Evaluator: Conflict or Cooperation?

ERIC Educational Resources Information Center

Feigenbaum, Laurel; And Others

This paper discusses observations found upon examining district management styles (autocratic vs. democratic) in evaluation offices and evaluation management levels (federal, state, and local) in relationship to the creativity and effectiveness of internal evaluators and usefulness of feedback information to the school site. (Author)

Supporting elementary science education for English learners: An evaluation instrument to promote constructivist teaching

NASA Astrophysics Data System (ADS)

Gibbons, Beatrice Lowney

2002-01-01

The purpose of this study was to develop an evaluation instrument to be used by elementary school administrators in the promotion of constructivist teaching of elementary science for English Learners using a qualitative and quantitative design that identified effective instructional strategies to be included on the evaluation instrument. This study was conducted in fifth grade classrooms of predominately English Learners whose teachers are CLAD-certified, tenured teachers with at least three years of teaching experience. The classroom observations took place within a multicultural school district with predominantly Hispanic and Filipino students in the Southern San Joaquin Valley of California. The evaluation instrument was used to observe these teachers teach elementary science lessons to classrooms of predominately English Learners. The frequency of the use of the ELD/SDAIE instructional strategies were noted on the evaluation instrument with a check mark, indicating the fact that an instructional technique was employed by the teacher. These observation visits revealed what type of instructional strategies were being utilized in the teaching of science to fifth grade English Learners, whether these CLAD-certified teachers were using ELD strategies, and whether the incidence of ELD/SDAIE constructivist instructional techniques increased with the repeated use of the evaluation instrument. As a result of this study, an evaluation instrument to be utilized by school administrators in the evaluation of elementary science instruction to English Learners was developed. The repeated use of this evaluation instrument coupled with preobservation and postobservation conferences may result in the increase in frequency of ELD/SDAIE methodology and constructivist strategies listed on the evaluation instrument in the elementary science classroom.

Implementation Evaluation Study: Flipped Classroom Professional Development with Faculty Members to Enhance Students' Engagement in Higher Education

ERIC Educational Resources Information Center

Alebrahim, Fatimah Hussain

2016-01-01

The purpose of this qualitative study was to explore student engagement in higher education by evaluating training provided by experienced faculty members for those faculty desiring to implement a flipped classroom. A case study was utilized; data were collected in the form of online observation, in-class observation, student focus group…

OZONE PRODUCTION EFFICIENCY AND NOX DEPLETION IN AN URBAN PLUME: INTERPRETATION OF FIELD OBSERVATIONS AND IMPLICATIONS FOR EVALUATING O3-NOX-VOC SENSITIVITY

EPA Science Inventory

Ozone production efficiency (OPE) can be defined as the number of ozone (O3) molecules photochemically produced by a molecule of NOx (NO + NO2) before it is lost from the NOx - O3 cycle. Here, we consider observational and modeling techniques to evaluate various operational defi...

Evaluating the Effectiveness of the Stimulus Pairing Observation Procedure and Multiple Exemplar Instruction on Tact and Listener Responses in Children with Autism

ERIC Educational Resources Information Center

Byrne, Brittany L.; Rehfeldt, Ruth Anne; Aguirre, Angelica A.

2014-01-01

The stimulus pairing observation procedure (SPOP) combined with multiple exemplar instruction (MEI) has been shown to be effective with typically developing preschoolers in establishing the joint stimulus control required for the development of naming. The purpose of the current investigation was to evaluate the effectiveness and efficiency of the…

The Use of Videotape Recordings to Teach Clinical Skills (Evaluation and Remediation) In the Fields of Communicative Disorders.

ERIC Educational Resources Information Center

Billeaud, Frances P.

A study was undertaken to evaluate the benefits derived by speech and language pathology students who used video tape recordings to learn diagnosis of communication disorders, to observe professional therapists and therapy programs, and to improve their own clinical techniques through self-observation. The use of video tapes to teach clinical…

Patterns of northern red oak growth and mortality in western Pennsylvania

Treesearch

J. R. McClenahen; R. J. Hutnik; D. D. Davis

1997-01-01

This study evaluates the extent and cause(s) of an observed decline of northern red oak (Quercus rubra L.) on a 50-km portion of a major anticlinal ridge in west central Pennsylvania, and illustrates an approach for evaluating tree declines. Long term annual observations of forest health revealed the onset of crown dieback in 1983, chiefly among red...

Infrared Algorithm Development for Ocean Observations with EOS/MODIS

NASA Technical Reports Server (NTRS)

Brown, Otis B.

1997-01-01

Efforts continue under this contract to develop algorithms for the computation of sea surface temperature (SST) from MODIS infrared measurements. This effort includes radiative transfer modeling, comparison of in situ and satellite observations, development and evaluation of processing and networking methodologies for algorithm computation and data accession, evaluation of surface validation approaches for IR radiances, development of experimental instrumentation, and participation in MODIS (project) related activities. Activities in this contract period have focused on radiative transfer modeling, evaluation of atmospheric correction methodologies, undertake field campaigns, analysis of field data, and participation in MODIS meetings.

Footprint Representation of Planetary Remote Sensing Data

NASA Astrophysics Data System (ADS)

Walter, S. H. G.; Gasselt, S. V.; Michael, G.; Neukum, G.

The geometric outline of remote sensing image data, the so called footprint, can be represented as a number of coordinate tuples. These polygons are associated with according attribute information such as orbit name, ground- and image resolution, solar longitude and illumination conditions to generate a powerful base for classification of planetary experiment data. Speed, handling and extended capabilites are the reasons for using geodatabases to store and access these data types. Techniques for such a spatial database of footprint data are demonstrated using the Relational Database Management System (RDBMS) PostgreSQL, spatially enabled by the PostGIS extension. Exemplary, footprints of the HRSC and OMEGA instruments, both onboard ESA's Mars Express Orbiter, are generated and connected to attribute information. The aim is to provide high-resolution footprints of the OMEGA instrument to the science community for the first time and make them available for web-based mapping applications like the "Planetary Interactive GIS-on-the-Web Analyzable Database" (PIG- WAD), produced by the USGS. Map overlays with HRSC or other instruments like MOC and THEMIS (footprint maps are already available for these instruments and can be integrated into the database) allow on-the-fly intersection and comparison as well as extended statistics of the data. Footprint polygons are generated one by one using standard software provided by the instrument teams. Attribute data is calculated and stored together with the geometric information. In the case of HRSC, the coordinates of the footprints are already available in the VICAR label of each image file. Using the VICAR RTL and PostgreSQL's libpq C library they are loaded into the database using the Well-Known Text (WKT) notation by the Open Geospatial Consortium, Inc. (OGC). For the OMEGA instrument, image data is read using IDL routines developed and distributed by the OMEGA team. Image outlines are exported together with relevant attribute data to the industry standard Shapefile format. These files are translated to a Structured Query Language (SQL) command sequence suitable for insertion into the PostGIS/PostgrSQL database using the shp2pgsql data loader provided by the PostGIS software. PostgreSQL's advanced features such as geometry types, rules, operators and functions allow complex spatial queries and on-the-fly processing of data on DBMS level e.g. generalisation of the outlines. Processing done by the DBMS, visualisation via GIS systems and utilisation for web-based applications like mapservers will be demonstrated.

Alcohol and drugs use among drivers injured in road accidents in Campania (Italy): A 8-years retrospective analysis.

PubMed

Carfora, Anna; Campobasso, Carlo Pietro; Cassandro, Paola; Petrella, Raffaella; Borriello, Renata

2018-05-09

A recent update of the Italian Road Traffic Law (RTL 41/2016), established severe penal sanctions when drivers, driving under the influence of alcohol (DUI) or drugs (DUID), are involved in road accident that results in death or injuries. A study was carried out to assess the trends of consumption of alcohol, illicit drugs or pharmaceutical among injured drivers suspected for DUI or DUID from 2009 to 2016 in the region of Campania (Italy). Confirmation toxicological analyses were performed on 780 blood samples and 1017 urine samples collected from 1797 injured drivers. These drivers all tested positive for alcohol or drug use through immunoassay screening applied at hospital emergency units and their biological samples transferred to the Forensic Reference Laboratory (FRL) for confirmation analysis. The GC/HS-FID methodology was used to test Blood Alcohol Concentration (BAC). Qualitative and quantitative analyses for drugs were performed using the GC/MS or LC-MS/MS methodology. The BAC >0.5g/L was confirmed in 91.5% of drivers suspected for DUI cases and in 93% of DUID respectively. In DUI cases, results show an increasing incidence of road accidents involving drivers with BAC above 1.5g/L while at concentrations above 0.8g/L alcohol and drugs are both used. Among the suspected DUID cases, the intake of alcohol in association with drugs has consistently increased over time and positive results on blood samples was confirmed for multiple drugs (20%) or cannabis and cocaine alone (18%) followed by benzodiazepines (6%) and methadone (3.5%) respectively. The majority of injured drivers suspected for DUID (1017 cases) did not authorize blood sampling, therefore only urine was analyzed showing the prevalent use of cannabis, followed by multiple drug>cocaine>benzodiazepines>opiates. Among 1797 drivers, suspected at screening for DUI or DUID, 15.4% of cases (64 blood and 213 urine samples) were not confirmed by GC/HS, GC/MS or LC-MS/MS analysis. In forensic toxicological investigations, it is mandatory to satisfy the best quality standards, which is not achievable if immunochemical screening is only performed on urine. Therefore, only confirmed positive results of alcohol or drugs on blood samples can represent conclusive evidence to demonstrate the DUI or DUID related offences. An improvement of the protocols currently applied in Italy for the assessment of DUI or DUID crimes is needed and the confirmation analysis on blood should be considered mandatory. Copyright © 2018 Elsevier B.V. All rights reserved.

Intelligent microchip networks: an agent-on-chip synthesis framework for the design of smart and robust sensor networks

NASA Astrophysics Data System (ADS)

Bosse, Stefan

2013-05-01

Sensorial materials consisting of high-density, miniaturized, and embedded sensor networks require new robust and reliable data processing and communication approaches. Structural health monitoring is one major field of application for sensorial materials. Each sensor node provides some kind of sensor, electronics, data processing, and communication with a strong focus on microchip-level implementation to meet the goals of miniaturization and low-power energy environments, a prerequisite for autonomous behaviour and operation. Reliability requires robustness of the entire system in the presence of node, link, data processing, and communication failures. Interaction between nodes is required to manage and distribute information. One common interaction model is the mobile agent. An agent approach provides stronger autonomy than a traditional object or remote-procedure-call based approach. Agents can decide for themselves, which actions are performed, and they are capable of flexible behaviour, reacting on the environment and other agents, providing some degree of robustness. Traditionally multi-agent systems are abstract programming models which are implemented in software and executed on program controlled computer architectures. This approach does not well scale to micro-chip level and requires full equipped computers and communication structures, and the hardware architecture does not consider and reflect the requirements for agent processing and interaction. We propose and demonstrate a novel design paradigm for reliable distributed data processing systems and a synthesis methodology and framework for multi-agent systems implementable entirely on microchip-level with resource and power constrained digital logic supporting Agent-On-Chip architectures (AoC). The agent behaviour and mobility is fully integrated on the micro-chip using pipelined communicating processes implemented with finite-state machines and register-transfer logic. The agent behaviour, interaction (communication), and mobility features are modelled and specified on a machine-independent abstract programming level using a state-based agent behaviour language (APL). With this APL a high-level agent compiler is able to synthesize a hardware model (RTL, VHDL), a software model (C, ML), or a simulation model (XML) suitable to simulate a multi-agent system using the SeSAm simulator framework. Agent communication is provided by a simple tuple-space database implemented on node level providing fault tolerant access of global data. A novel synthesis development kit (SynDK) based on a graph-structured database approach is introduced to support the rapid development of compilers and synthesis tools, used for example for the design and implementation of the APL compiler.

Informative Bayesian Type A uncertainty evaluation, especially applicable to a small number of observations

NASA Astrophysics Data System (ADS)

Cox, M.; Shirono, K.

2017-10-01

A criticism levelled at the Guide to the Expression of Uncertainty in Measurement (GUM) is that it is based on a mixture of frequentist and Bayesian thinking. In particular, the GUM’s Type A (statistical) uncertainty evaluations are frequentist, whereas the Type B evaluations, using state-of-knowledge distributions, are Bayesian. In contrast, making the GUM fully Bayesian implies, among other things, that a conventional objective Bayesian approach to Type A uncertainty evaluation for a number n of observations leads to the impractical consequence that n must be at least equal to 4, thus presenting a difficulty for many metrologists. This paper presents a Bayesian analysis of Type A uncertainty evaluation that applies for all n ≥slant 2 , as in the frequentist analysis in the current GUM. The analysis is based on assuming that the observations are drawn from a normal distribution (as in the conventional objective Bayesian analysis), but uses an informative prior based on lower and upper bounds for the standard deviation of the sampling distribution for the quantity under consideration. The main outcome of the analysis is a closed-form mathematical expression for the factor by which the standard deviation of the mean observation should be multiplied to calculate the required standard uncertainty. Metrological examples are used to illustrate the approach, which is straightforward to apply using a formula or look-up table.

On the assimilation set-up of ASCAT soil moisture data for improving streamflow catchment simulation

NASA Astrophysics Data System (ADS)

Loizu, Javier; Massari, Christian; Álvarez-Mozos, Jesús; Tarpanelli, Angelica; Brocca, Luca; Casalí, Javier

2018-01-01

Assimilation of remotely sensed surface soil moisture (SSM) data into hydrological catchment models has been identified as a means to improve streamflow simulations, but reported results vary markedly depending on the particular model, catchment and assimilation procedure used. In this study, the influence of key aspects, such as the type of model, re-scaling technique and SSM observation error considered, were evaluated. For this aim, Advanced SCATterometer ASCAT-SSM observations were assimilated through the ensemble Kalman filter into two hydrological models of different complexity (namely MISDc and TOPLATS) run on two Mediterranean catchments of similar size (750 km2). Three different re-scaling techniques were evaluated (linear re-scaling, variance matching and cumulative distribution function matching), and SSM observation error values ranging from 0.01% to 20% were considered. Four different efficiency measures were used for evaluating the results. Increases in Nash-Sutcliffe efficiency (0.03-0.15) and efficiency indices (10-45%) were obtained, especially when linear re-scaling and observation errors within 4-6% were considered. This study found out that there is a potential to improve streamflow prediction through data assimilation of remotely sensed SSM in catchments of different characteristics and with hydrological models of different conceptualizations schemes, but for that, a careful evaluation of the observation error and re-scaling technique set-up utilized is required.

A method for evaluating the importance of system state observations to model predictions, with application to the Death Valley regional groundwater flow system

USGS Publications Warehouse

Tiedeman, Claire; Ely, D. Matthew; Hill, Mary C.; O'Brien, Grady M.

2004-01-01

We develop a new observation‐prediction (OPR) statistic for evaluating the importance of system state observations to model predictions. The OPR statistic measures the change in prediction uncertainty produced when an observation is added to or removed from an existing monitoring network, and it can be used to guide refinement and enhancement of the network. Prediction uncertainty is approximated using a first‐order second‐moment method. We apply the OPR statistic to a model of the Death Valley regional groundwater flow system (DVRFS) to evaluate the importance of existing and potential hydraulic head observations to predicted advective transport paths in the saturated zone underlying Yucca Mountain and underground testing areas on the Nevada Test Site. Important existing observations tend to be far from the predicted paths, and many unimportant observations are in areas of high observation density. These results can be used to select locations at which increased observation accuracy would be beneficial and locations that could be removed from the network. Important potential observations are mostly in areas of high hydraulic gradient far from the paths. Results for both existing and potential observations are related to the flow system dynamics and coarse parameter zonation in the DVRFS model. If system properties in different locations are as similar as the zonation assumes, then the OPR results illustrate a data collection opportunity whereby observations in distant, high‐gradient areas can provide information about properties in flatter‐gradient areas near the paths. If this similarity is suspect, then the analysis produces a different type of data collection opportunity involving testing of model assumptions critical to the OPR results.

A Focused Observation Tool Using Dreyfus Stages of Skill Acquisition as an Evaluative Scale.

PubMed

Driver, Richard; Grose, Brian; Serafini, Mario; Cottrell, Scott; Sizemore, Daniel; Vallejo, Manuel

2017-01-01

Focused Observartion (FO) is associated with assessing complex skills and differs from generalized observations and evaluations. We've developed a FO assessing clinical procedural skills using Hubert Dreyfus Stages of Skill Acquisition as descriptive anchors. This study sought to analyze the effectiveness of this measure of skill progression. During week 1 and week 4 of training, FO was performed repetitively on 6 residents during endotracheal intubation. Skill stage ratings were converted to numerical scores. A dependent, paired samples t-test was calculated using total mean score (dependent variable) and an effect size. (Cohen's d) was performed to ascertain the standardized mean difference between observations. A significant improvement in mean scores occurred between Week 1 (AVG 1.2, STDV ± 0.1) and Week 4 (AVG 2.0, STDV ± 0.1) (t= -3.9, p<.05) Calculated Chohen's d indicates that this difference was meaningful. This study demonstrates success in adapting a Focused Observation technique and an innovative evaluative scale based upon Dreyfus stages of skill acquisition.

[Application of single-retainer all-ceramic resin-bonded fixed partial denture in replacing single anterior tooth].

PubMed

Lili, Yang; Debiao, Du; Ruoyu, Ning; Deying, Chen; Junling, Wu

2017-08-01

Objective In this study, we aimed to evaluate the clinical effect of single-retainer all-ceramic resin-bonded fixed partial denture (RBFPD) on the single anterior tooth loss patients. Methods A total of 20 single-retainer all-ceramic RBFPD
were fabricated and evaluated in a two-year follow-up observation. The restorations were examined on the basis of the American Public Health Association (APHA) criteria. Results A total of 20 single-retainer all-ceramic RBFPD achieved class A evaluation after a six-month follow-up observation. One single-retainer all-ceramic RBFPD was classified as class B for secondary caries after a one-year follow-up observation. After a two-year follow-up observation, one single-retainer all-ceramic RBFPD was classified as class B because of secondary caries, and one single-retainer all-ceramic RBFPD was classified as class B because of fracture. Conclusion Single-retainer all-ceramic RBFPD is a promising and optional method in replacing single anterior tooth.

A Statistical Analysis of Reviewer Agreement and Bias in Evaluating Medical Abstracts 1

PubMed Central

Cicchetti, Domenic V.; Conn, Harold O.

1976-01-01

Observer variability affects virtually all aspects of clinical medicine and investigation. One important aspect, not previously examined, is the selection of abstracts for presentation at national medical meetings. In the present study, 109 abstracts, submitted to the American Association for the Study of Liver Disease, were evaluated by three “blind” reviewers for originality, design-execution, importance, and overall scientific merit. Of the 77 abstracts rated for all parameters by all observers, interobserver agreement ranged between 81 and 88%. However, corresponding intraclass correlations varied between 0.16 (approaching statistical significance) and 0.37 (p < 0.01). Specific tests of systematic differences in scoring revealed statistically significant levels of observer bias on most of the abstract components. Moreover, the mean differences in interobserver ratings were quite small compared to the standard deviations of these differences. These results emphasize the importance of evaluating the simple percentage of rater agreement within the broader context of observer variability and systematic bias. PMID:997596

10 CFR 712.37 - Evaluation for hallucinogen use.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Evaluation for hallucinogen use. 712.37 Section 712.37 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Medical Standards § 712.37 Evaluation for... performance and observed behavior. ...

10 CFR 712.37 - Evaluation for hallucinogen use.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Evaluation for hallucinogen use. 712.37 Section 712.37 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Medical Standards § 712.37 Evaluation for... performance and observed behavior. ...

10 CFR 712.37 - Evaluation for hallucinogen use.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Evaluation for hallucinogen use. 712.37 Section 712.37 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Medical Standards § 712.37 Evaluation for... performance and observed behavior. ...

10 CFR 712.37 - Evaluation for hallucinogen use.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Evaluation for hallucinogen use. 712.37 Section 712.37 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Medical Standards § 712.37 Evaluation for... performance and observed behavior. ...

10 CFR 712.37 - Evaluation for hallucinogen use.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Evaluation for hallucinogen use. 712.37 Section 712.37 Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Medical Standards § 712.37 Evaluation for... performance and observed behavior. ...

Interviewer as instrument: accounting for human factors in evaluation research.

PubMed

Brown, Joel H

2006-04-01

This methodological study examines an original data collection model designed to incorporate human factors and enhance data richness in qualitative and evaluation research. Evidence supporting this model is drawn from in-depth youth and adult interviews in one of the largest policy/program evaluations undertaken in the United States, the Drug, Alcohol, and Tobacco Education evaluation (77 districts, 118 schools). When applying the explicit observation technique (EOT)--the strategic and nonjudgmental disclosure of nonverbal human factor cues by the interviewer to the respondent during interview--data revealed the observation disclosure pattern. Here, respondents linked perceptions with policy or program implementation or effectiveness evidence. Although more research is needed, it is concluded that the EOT yields richer data when compared with traditional semistructured interviews and, thus, holds promise to enhance qualitative and evaluation research methods. Validity and reliability as well as qualitative and evaluation research considerations are discussed.

Rural Principals and the North Carolina Teacher Evaluation Process: How Has the Transition from the TPAI-R to the New Evaluation Process Changed Principals' Evaluative Practices?

ERIC Educational Resources Information Center

Fuller, Charles Avery

2016-01-01

Beginning with the 2010-2011 school year the North Carolina State Board of Education (SBE) mandated the use of the North Carolina Teacher Evaluation Process (Evaluation Process) for use in all public school systems in the state to conduct teacher observations and evaluations. The Evaluation Process replaced the Teacher Performance Appraisal…

Planning for an Evaluation of Teaching Performance. Volume IV. Summaries of Instruments for Use in Evaluating Teacher Performance.

ERIC Educational Resources Information Center

Yuzdepski, I., Comp.; Elliott, L., Comp.

This document presents information, in the form of summary sheets, on 54 teacher evaluation instruments. Each summary contains pertinent information about the instrument regarding publishing company, author, criteria evaluated, subject of observation, category dimension, and coding units. The 19 criteria used in the evaluation tests, which were…

Self-rated and observer-rated measures of well-being and distress in adolescence: an exploratory study.

PubMed

Vescovelli, Francesca; Albieri, Elisa; Ruini, Chiara

2014-01-01

The evaluation of eudaimonic well-being in adolescence is hampered by the lack of specific assessment tools. Moreover, with younger populations, the assessment of positive functioning may be biased by self-report data only, and may be more accurate by adding significant adults' evaluations. The objective of this research was to measure adolescents' well-being and prosocial behaviours using self-rated and observer-rated instruments, and their pattern of associations. The sample included 150 Italian high school adolescents. Observed-evaluation was performed by their school teachers using the Strengths and Difficulties Questionnaire. Adolescents completed Ryff's Psychological Well-being Scales and Symptom Questionnaire. Pearson' r correlations and Linear regression were performed. Self-rated dimensions of psychological well-being significantly correlated with all observer-rated dimensions, but Strengths and Difficulties Emotional symptom scale. Multiple linear regression showed that the self-rated dimensions Environmental Mastery and Personal Growth, and surprisingly not Positive Relations, are related to the observer-rated dimension Prosocial Behaviour. Adolescents with higher levels of well-being in specific dimensions tend to be perceived as less problematic by their teachers. However, some dimensions of positive functioning present discrepancies between self and observer-rated instruments. Thus, the conjunct use of self-reports and observer-rated tools for a more comprehensive assessment of students' eudaimonic well-being is recommended.

The Effect of Observation Length and Presentation Order on the Reliability and Validity of an Observational Measure of Teaching Quality

ERIC Educational Resources Information Center

Mashburn, Andrew J.; Meyer, J. Patrick; Allen, Joseph P.; Pianta, Robert C.

2014-01-01

Observational methods are increasingly being used in classrooms to evaluate the quality of teaching. Operational procedures for observing teachers are somewhat arbitrary in existing measures and vary across different instruments. To study the effect of different observation procedures on score reliability and validity, we conducted an experimental…

Does a Teacher's Classroom Observation Rating Vary across Multiple Classrooms?

ERIC Educational Resources Information Center

Lei, Xiaoxuan; Li, Hongli; Leroux, Audrey J.

2018-01-01

Classroom observations have been increasingly used for teacher evaluations, and it is important to examine the measurement quality and the use of observation ratings. When a teacher is observed in multiple classrooms, his or her observation ratings may vary across classrooms. In that case, using ratings from one classroom per teacher may not be…

Inside the Black Box--An Implementation Evaluation Case Study

ERIC Educational Resources Information Center

Rector, Patricia; Bakacs, Michele; Rowe, Amy; Barbour, Bruce

2016-01-01

The case study presented in this article is an example of an implementation evaluation. The evaluation investigated significant components of the implementation of a long-term environmental educational program. Direct observation, evaluation-specific survey data, and historical data were used to determine program integrity as identified by…

75 FR 81201 - 2011 Annual Determination for Sea Turtle Observer Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-27

...-XA016 2011 Annual Determination for Sea Turtle Observer Requirement AGENCY: National Marine Fisheries... observers upon NMFS' request. The purpose of observing identified fisheries is to learn more about sea turtle interactions in a given fishery, evaluate existing measures to prevent or reduce prohibited sea...

Evaluating Observational Learning in a Competitive Two-Sided Crowdsourcing Market: A Bayesian Inferential Approach

ERIC Educational Resources Information Center

Ayaburi, Emmanuel Wusuhon Yanibo

2017-01-01

This dissertation investigates the effect of observational learning in crowdsourcing markets as a lens to identify appropriate mechanism(s) for sustaining this increasingly popular business model. Observational learning occurs when crowdsourcing participating agents obtain knowledge from signals they observe in the marketplace and incorporate such…

Evaluation of the Revised Algorithm of Autism Diagnostic Observation Schedule (ADOS) in the Diagnostic Investigation of High-Functioning Children and Adolescents with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Kamp-Becker, Inge; Ghahreman, Mardjan; Heinzel-Gutenbrunner, Monika; Peters, Mira; Remschmidt, Helmut; Becker, Katja

2013-01-01

The Autism Diagnostic Observation Schedule (ADOS) is a semi-structured, standardized assessment designed for use in diagnostic evaluation of individuals with suspected autism spectrum disorder (ASD). The ADOS has been effective in categorizing children who definitely have autism or not, but has lower specificity and sometimes sensitivity for…

Resistance to Classroom Observation in the Context of Teacher Evaluation: Teachers' and Department Heads' Experiences and Perspectives

ERIC Educational Resources Information Center

de Lima, Jorge Ávila; Silva, Maria João Tavares

2018-01-01

This paper reports the main findings of a study that sought to understand how teachers and department heads perceived and experienced the implementation of a classroom observation system in a teacher evaluation context. The data was collected through a teacher and department head survey and interviews with department heads who were responsible for…

Profile and Remote Sensing Observation Datasets (Trace Gases and Aerosols) for Regional- Scale Model Evaluation under the Air Quality Model Evaluation International Initiative (AQMEII)- North American and European Perspectives

EPA Science Inventory

While the vast majority of operational air-pollution networks across the world are designed to measure relevant metrics at the surface, the air pollution problem is a three-dimensional phenomenon. The lack of adequate observations aloft to routinely characterize the nature of ai...

Evaluation of multi-model aerosol distributions over East Asia using in-situ and satellite observations during summer 2008

NASA Astrophysics Data System (ADS)

Quennehen, B.; Raut, J.; Law, K.; Ancellet, G.; Bazureau, A.; Thomas, J.; Daskalakis, N.; Kim, S.; Zhu, T.

2013-12-01

As part of the EU ECLIPSE (Evaluating the CLimate and air quality ImPacts of Short-livEd pollutants) project, which aims to quantify the climate impact of short lived climate forcers (SLCFs), including aerosols, black carbon and ozone, the WRF-Chem regional and six global (ECHAM6, EMEP, HadGEM, OsloCTM, NORESM, TM4) models are evaluated using observations in East-Asia. Simulations are compared at horizontal and vertical scales to satellite observations, as well as data from field campaigns which took place in summer 2008, and from long-term measurement stations. Models were run with the same emissions, namely, the ECLIPSE anthropogenic (based on the GAINS model), GFED 3.1 fire and RCP 6.0 ship and aircraft emissions for 2008. The initial and boundary conditions for the WRF-Chem regional model were specified from the TM4 global chemical transport model. Firstly, this study evaluates the ability of the models to simulate aerosol physical, optical and chemical properties at a large scale, both horizontally and vertically, using monthly mean satellite observations such as CALIPSO, MODIS and IASI. Secondly, model daily and hourly results are evaluated at more regional/local scales using ground-based data and measurements from summer 2008 intensive campaigns, including aircraft data (CAPMEX and CAREBEIJING). In this study, we assess aerosol total concentrations and size distributions simulated by the model. The radiative impact of anthropogenic aerosol layers has already been investigated but less is known about the influence of vertical layering in the atmosphere. Pollution layers have different radiative impacts whether they are below or above clouds and in that sense, a better understanding of their spatial and vertical extent is critical. Information about pollution layers and cloud optical properties and locations over East-Asia are determined using observations from IASI for trace gases and CALIPSO for aerosols. The radiative impact of the aerosol layers is simulated and compared to the observations. The impact of differences in the evaluated parameters on the radiative calculations will be estimated.

The disagreement between the ideal observer and human observers in hardware and software imaging system optimization: theoretical explanations and evidence

NASA Astrophysics Data System (ADS)

He, Xin

2017-03-01

The ideal observer is widely used in imaging system optimization. One practical question remains open: do the ideal and human observers have the same preference in system optimization and evaluation? Based on the ideal observer's mathematical properties proposed by Barrett et. al. and the empirical properties of human observers investigated by Myers et. al., I attempt to pursue the general rules regarding the applicability of the ideal observer in system optimization. Particularly, in software optimization, the ideal observer pursues data conservation while humans pursue data presentation or perception. In hardware optimization, the ideal observer pursues a system with the maximum total information, while humans pursue a system with the maximum selected (e.g., certain frequency bands) information. These different objectives may result in different system optimizations between human and the ideal observers. Thus, an ideal observer optimized system is not necessarily optimal for humans. I cite empirical evidence in search and detection tasks, in hardware and software evaluation, in X-ray CT, pinhole imaging, as well as emission computed tomography to corroborate the claims. (Disclaimer: the views expressed in this work do not necessarily represent those of the FDA)

Evaluation of Long-Term Cloud-Resolving Model Simulations Using Satellite Radiance Observations and Multi-Frequency Satellite Simulators

NASA Technical Reports Server (NTRS)

Matsui, Toshihisa; Zeng, Xiping; Tao, Wei-Kuo; Masunaga, Hirohiko; Olson, William S.; Lang, Stephen

2008-01-01

This paper proposes a methodology known as the Tropical Rainfall Measuring Mission (TRMM) Triple-Sensor Three-step Evaluation Framework (T3EF) for the systematic evaluation of precipitating cloud types and microphysics in a cloud-resolving model (CRM). T3EF utilizes multi-frequency satellite simulators and novel statistics of multi-frequency radiance and backscattering signals observed from the TRMM satellite. Specifically, T3EF compares CRM and satellite observations in the form of combined probability distributions of precipitation radar (PR) reflectivity, polarization-corrected microwave brightness temperature (Tb), and infrared Tb to evaluate the candidate CRM. T3EF is used to evaluate the Goddard Cumulus Ensemble (GCE) model for cases involving the South China Sea Monsoon Experiment (SCSMEX) and Kwajalein Experiment (KWAJEX). This evaluation reveals that the GCE properly captures the satellite-measured frequencies of different precipitating cloud types in the SCSMEX case but underestimates the frequencies of deep convective and deep stratiform types in the KWAJEX case. Moreover, the GCE tends to simulate excessively large and abundant frozen condensates in deep convective clouds as inferred from the overestimated GCE-simulated radar reflectivities and microwave Tb depressions. Unveiling the detailed errors in the GCE s performance provides the best direction for model improvements.

Verification of NWP Cloud Properties using A-Train Satellite Observations

NASA Astrophysics Data System (ADS)

Kucera, P. A.; Weeks, C.; Wolff, C.; Bullock, R.; Brown, B.

2011-12-01

Recently, the NCAR Model Evaluation Tools (MET) has been enhanced to incorporate satellite observations for the verification of Numerical Weather Prediction (NWP) cloud products. We have developed tools that match fields spatially (both in the vertical and horizontal dimensions) to compare NWP products with satellite observations. These matched fields provide diagnostic evaluation of cloud macro attributes such as vertical distribution of clouds, cloud top height, and the spatial and seasonal distribution of cloud fields. For this research study, we have focused on using CloudSat, CALIPSO, and MODIS observations to evaluate cloud fields for a variety of NWP fields and derived products. We have selected cases ranging from large, mid-latitude synoptic systems to well-organized tropical cyclones. For each case, we matched the observed cloud field with gridded model and/or derived product fields. CloudSat and CALIPSO observations and model fields were matched and compared in the vertical along the orbit track. MODIS data and model fields were matched and compared in the horizontal. We then use MET to compute the verification statistics to quantify the performance of the models in representing the cloud fields. In this presentation we will give a summary of our comparison and show verification results for both synoptic and tropical cyclone cases.

Performance Evaluation of the United Nations Environment Programme Air Quality Monitoring Unit

EPA Pesticide Factsheets

This report defines the specifics of the environmental test conditions used in the evaluation (systems and conditions), data observations, summarization of key performance evaluation findings, and ease of use features concerning the UNEP pod.

NORTHERN OHIO AEROSOL STUDY: STAPHYLOCOCCUS AUREUS EVALUATION

EPA Science Inventory

A consortium of Universities, located in northwest Ohio have received funds to conduct a comprehensive evaluation of land applied biosolids in that state. This USDA funded study includes observing land application practices and evaluating biosolids, soils, runoff water and bioaer...

Carbon Monoxide Data Assimilation for Atmospheric Composition and Climate Science: Evaluating Performance with Current and Future Observations

NASA Astrophysics Data System (ADS)

Barre, J.; Edwards, D. P.; Gaubert, B.; Worden, H. M.; Arellano, A. F.; Anderson, J. L.

2015-12-01

Current satellite observations of tropospheric composition made from low Earth orbit provide at best one or two measurements each day at any given location. Comparisons of Terra/MOPITT carbon monoxide (CO) and IASI/Metop CO observation assimilations will be presented. We use the DART Ensemble Adjustment Kalman Filter to assimilate observations in the CAM-Chem global chemistry-climate model. Data assimilation impacts due to both different instrument capabilities (i.e. vertical sensitivity and global coverage) will be discussed. Coverage is global but sparse, often with large uncertainties in individual measurements that limit examination of local and regional atmospheric composition over short time periods. This has hindered the operational uptake of these data for monitoring air quality and population exposure, and for initializing and evaluating chemical weather forecasts. By the end of the current decade there are planned geostationary Earth orbit (GEO) satellite missions for atmospheric composition over North America, East Asia and Europe with additional missions proposed. Together, these present the possibility of a constellation of geostationary platforms to achieve continuous time-resolved high-density observations of continental domains for mapping pollutant sources and variability on diurnal and local scales. We describe Observing System Simulation Experiments (OSSEs) to evaluate the contributions of these GEO missions to improve knowledge of near-surface air pollution due to intercontinental long-range transport and quantify chemical precursor emissions. Our approach uses an efficient computational method to sample a high-resolution global GEOS-5 chemistry Nature Run over each geographical region of the GEO constellation. The demonstration carbon monoxide (CO) observation simulator, which will be expanded to other chemical pollutants, currently produces multispectral retrievals (MOPITT-like) and captures realistic scene-dependent variation in measurement vertical sensitivity and cloud cover. The impact of observing over each region is evaluated independently. Winter and summer cases studies are investigated i.e. where emissions, cloud cover and CO lifetime significantly change.

Independent evaluation of point source fossil fuel CO2 emissions to better than 10%

PubMed Central

Turnbull, Jocelyn Christine; Keller, Elizabeth D.; Norris, Margaret W.; Wiltshire, Rachael M.

2016-01-01

Independent estimates of fossil fuel CO2 (CO2ff) emissions are key to ensuring that emission reductions and regulations are effective and provide needed transparency and trust. Point source emissions are a key target because a small number of power plants represent a large portion of total global emissions. Currently, emission rates are known only from self-reported data. Atmospheric observations have the potential to meet the need for independent evaluation, but useful results from this method have been elusive, due to challenges in distinguishing CO2ff emissions from the large and varying CO2 background and in relating atmospheric observations to emission flux rates with high accuracy. Here we use time-integrated observations of the radiocarbon content of CO2 (14CO2) to quantify the recently added CO2ff mole fraction at surface sites surrounding a point source. We demonstrate that both fast-growing plant material (grass) and CO2 collected by absorption into sodium hydroxide solution provide excellent time-integrated records of atmospheric 14CO2. These time-integrated samples allow us to evaluate emissions over a period of days to weeks with only a modest number of measurements. Applying the same time integration in an atmospheric transport model eliminates the need to resolve highly variable short-term turbulence. Together these techniques allow us to independently evaluate point source CO2ff emission rates from atmospheric observations with uncertainties of better than 10%. This uncertainty represents an improvement by a factor of 2 over current bottom-up inventory estimates and previous atmospheric observation estimates and allows reliable independent evaluation of emissions. PMID:27573818

Independent evaluation of point source fossil fuel CO2 emissions to better than 10%.

PubMed

Turnbull, Jocelyn Christine; Keller, Elizabeth D; Norris, Margaret W; Wiltshire, Rachael M

2016-09-13

Independent estimates of fossil fuel CO2 (CO2ff) emissions are key to ensuring that emission reductions and regulations are effective and provide needed transparency and trust. Point source emissions are a key target because a small number of power plants represent a large portion of total global emissions. Currently, emission rates are known only from self-reported data. Atmospheric observations have the potential to meet the need for independent evaluation, but useful results from this method have been elusive, due to challenges in distinguishing CO2ff emissions from the large and varying CO2 background and in relating atmospheric observations to emission flux rates with high accuracy. Here we use time-integrated observations of the radiocarbon content of CO2 ((14)CO2) to quantify the recently added CO2ff mole fraction at surface sites surrounding a point source. We demonstrate that both fast-growing plant material (grass) and CO2 collected by absorption into sodium hydroxide solution provide excellent time-integrated records of atmospheric (14)CO2 These time-integrated samples allow us to evaluate emissions over a period of days to weeks with only a modest number of measurements. Applying the same time integration in an atmospheric transport model eliminates the need to resolve highly variable short-term turbulence. Together these techniques allow us to independently evaluate point source CO2ff emission rates from atmospheric observations with uncertainties of better than 10%. This uncertainty represents an improvement by a factor of 2 over current bottom-up inventory estimates and previous atmospheric observation estimates and allows reliable independent evaluation of emissions.

Evaluating the learning curve for robot-assisted laparoscopic radical cystectomy.

PubMed

Pruthi, Raj S; Smith, Angela; Wallen, Eric M

2008-11-01

We seek to describe the learning curve of robot-assisted laparoscopic radical cystectomy by evaluating some of the surgical, oncologic, and clinical outcomes in our initial experience with 50 consecutive patients undergoing this novel procedure. Fifty consecutive patients (representing our initial experience with robot-assisted cystectomy) underwent radical cystectomy and urinary diversion from January 2006 to December 2007. Several different metrics were used to evaluate the learning curve of this procedure, including estimated blood loss (EBL), operative (OR) time, pathologic outcomes, and complication rate. We evaluated patients as a continuous variable, divided into five distinct time periods (quintiles), and stratified by first half and second half of robotic experience. EBL was not significantly lower until the third quintile (patients 21-30), after which further significant reductions were not observed. Mean OR time declined between each quintile for the first 30 patients (1-10 v 11-20 v 21-30). No significant declines occurred after the third quintile (21-30). When evaluated as a continuous variable, the statistical cut point at which no further significant reductions were observed was after patient 20 for OR time. No differences were observed with regard to time to flatus, bowel movement, or hospital discharge. Furthermore, complications were not different between the initial 25 patients and the most recent patients. There has been no case of a positive margin, and there was only one inadvertent bladder entry. Lymph node yield has also not significantly changed over time. This report helps to define the learning curve associated with robot-assisted laparoscopic radical cystectomy for bladder cancer. Despite the higher OR times and blood loss that is observed early in the learning curve, no such compromises are observed with regard to these oncologic parameters even early in the experience.

Evaluation and Optimization of China's Anthropogenic CO2 Emissions using Observations from Northern China (2005-2009).

NASA Astrophysics Data System (ADS)

Dayalu, A.; Munger, J. W.; Wang, Y.; Wofsy, S.; Zhao, Y.; Nielsen, C. P.; Nehrkorn, T.; McElroy, M. B.; Chang, R.

2017-12-01

China has pledged to peak carbon emissions by 2030, but there continues to be significant uncertainty in estimates of its anthropogenic carbon dioxide (CO2) emissions. In this study, we evaluate the performance of three anthropogenic CO2 inventories, two global and one regional, using five years of continuous hourly observations from a site in Northern China. We model five years of continuous hourly observations (2005 to 2009) using the Stochastic Time-Inverted Lagrangian Transport Model (STILT) run in backward time mode driven by high resolution meteorology from the Weather Research and Forecasting Model version 3.6.1 (WRF) with vegetation fluxes prescribed by a simple biosphere model. We calculate regional enhancements to advected background CO2 derived from NOAA CarbonTracker on seasonal and annual bases and use observations to optimize emissions inventories within the site's influence region at these timescales. Finally, we use annual enhancements to examine carbon intensity of provinces in and adjacent to Northern China as CO2 per unit of the region's GDP to evaluate the effects of local and global economic events on CO2 emissions. With the exception of peak growing season where discrepancies are confounded by errors in the vegetation model, we find the regional inventory agrees significantly better with observations than the global inventories at all timescales. Here we use a single measurement site; significant improvements in inventory optimizations can be achieved with a network of measurements stations. This study highlights the importance of China-specific data over global averages in emissions evaluation and demonstrates the value of top-down studies in independently evaluating inventory performance. We demonstrate the framework's ability to resolve differences of at least 20% among inventories, establishing a benchmark for ongoing efforts to decrease uncertainty in China's reported CO2 emissions estimates.

A comparative agreement evaluation of two subaxial cervical spine injury classification systems: the AOSpine and the Allen and Ferguson schemes.

PubMed

Urrutia, Julio; Zamora, Tomas; Campos, Mauricio; Yurac, Ratko; Palma, Joaquin; Mobarec, Sebastian; Prada, Carlos

2016-07-01

We performed an agreement study using two subaxial cervical spine classification systems: the AOSpine and the Allen and Ferguson (A&F) classifications. We sought to determine which scheme allows better agreement by different evaluators and by the same evaluator on different occasions. Complete imaging studies of 65 patients with subaxial cervical spine injuries were classified by six evaluators (three spine sub-specialists and three senior orthopaedic surgery residents) using the AOSpine subaxial cervical spine classification system and the A&F scheme. The cases were displayed in a random sequence after a 6-week interval for repeat evaluation. The Kappa coefficient (κ) was used to determine inter- and intra-observer agreement. Inter-observer: considering the main AO injury types, the agreement was substantial for the AOSpine classification [κ = 0.61 (0.57-0.64)]; using AO sub-types, the agreement was moderate [κ = 0.57 (0.54-0.60)]. For the A&F classification, the agreement [κ = 0.46 (0.42-0.49)] was significantly lower than using the AOSpine scheme. Intra-observer: the agreement was substantial considering injury types [κ = 0.68 (0.62-0.74)] and considering sub-types [κ = 0.62 (0.57-0.66)]. Using the A&F classification, the agreement was also substantial [κ = 0.66 (0.61-0.71)]. No significant differences were observed between spine surgeons and orthopaedic residents in the overall inter- and intra-observer agreement, or in the inter- and intra-observer agreement of specific type of injuries. The AOSpine classification (using the four main injury types or at the sub-types level) allows a significantly better agreement than the A&F classification. The A&F scheme does not allow reliable communication between medical professionals.

Comparison of Male vs Female Resident Milestone Evaluations by Faculty During Emergency Medicine Residency Training

PubMed Central

Dayal, Arjun; O’Connor, Daniel M.; Qadri, Usama

2017-01-01

Importance Although implicit bias in medical training has long been suspected, it has been difficult to study using objective measures, and the influence of sex and gender in the evaluation of medical trainees is unknown. The emergency medicine (EM) milestones provide a standardized framework for longitudinal resident assessment, allowing for analysis of resident performance across all years and programs at a scope and level of detail never previously possible. Objective To compare faculty-observed training milestone attainment of male vs female residency training Design, Setting, and Participants This multicenter, longitudinal, retrospective cohort study took place at 8 community and academic EM training programs across the United States from July 1, 2013, to July 1, 2015, using a real-time, mobile-based, direct-observation evaluation tool. The study examined 33 456 direct-observation subcompetency evaluations of 359 EM residents by 285 faculty members. Main Outcomes and Measures Milestone attainment for male and female EM residents as observed by male and female faculty throughout residency and analyzed using multilevel mixed-effects linear regression modeling. Results A total of 33 456 direct-observation evaluations were collected from 359 EM residents (237 men [66.0%] and 122 women [34.0%]) by 285 faculty members (194 men [68.1%] and 91 women [31.9%]) during the study period. Female and male residents achieved similar milestone levels during the first year of residency. However, the rate of milestone attainment was 12.7% (0.07 levels per year) higher for male residents through all of residency (95% CI, 0.04-0.09). By graduation, men scored approximately 0.15 milestone levels higher than women, which is equivalent to 3 to 4 months of additional training, given that the average resident gains approximately 0.52 levels per year using our model (95% CI, 0.49-0.54). No statistically significant differences in scores were found based on faculty evaluator gender (effect size difference, 0.02 milestone levels; 95% CI for males, −0.09 to 0.11) or evaluator-evaluatee gender pairing (effect size difference, −0.02 milestone levels; 95% CI for interaction, −0.05 to 0.01). Conclusions and Relevance Although male and female residents receive similar evaluations at the beginning of residency, the rate of milestone attainment throughout training was higher for male than female residents across all EM subcompetencies, leading to a gender gap in evaluations that continues until graduation. Faculty should be cognizant of possible gender bias when evaluating medical trainees. PMID:28264090

Global Energy and Water Budgets in MERRA

NASA Technical Reports Server (NTRS)

Bosilovich, Michael G.; Robertson, Franklin R.; Chen, Junye

2010-01-01

Reanalyses, retrospectively analyzing observations over climatological time scales, represent a merger between satellite observations and models to provide globally continuous data and have improved over several generations. Balancing the Earth s global water and energy budgets has been a focus of research for more than two decades. Models tend to their own climate while remotely sensed observations have had varying degrees of uncertainty. This study evaluates the latest NASA reanalysis, called the Modern Era Retrospective-analysis for Research and Applications (MERRA), from a global water and energy cycles perspective. MERRA was configured to provide complete budgets in its output diagnostics, including the Incremental Analysis Update (IAU), the term that represents the observations influence on the analyzed states, alongside the physical flux terms. Precipitation in reanalyses is typically sensitive to the observational analysis. For MERRA, the global mean precipitation bias and spatial variability are more comparable to merged satellite observations (GPCP and CMAP) than previous generations of reanalyses. Ocean evaporation also has a much lower value which is comparable to observed data sets. The global energy budget shows that MERRA cloud effects may be generally weak, leading to excess shortwave radiation reaching the ocean surface. Evaluating the MERRA time series of budget terms, a significant change occurs, which does not appear to be represented in observations. In 1999, the global analysis increments of water vapor changes sign from negative to positive, and primarily lead to more oceanic precipitation. This change is coincident with the beginning of AMSU radiance assimilation. Previous and current reanalyses all exhibit some sensitivity to perturbations in the observation record, and this remains a significant research topic for reanalysis development. The effect of the changing observing system is evaluated for MERRA water and energy budget terms.

Evaluation of Patients’ Rights Observance According to Patients’ Rights Charter in Educational Hospitals Affiliated to Mashhad University of Medical Sciences: Medical Staffs’ Views

PubMed Central

Sabzevari, Alireza; Kiani, Mohammad Ali; Saeidi, Masumeh; Jafari, Seyed Ali; Kianifar, Hamidreza; Ahanchian, Hamid; Jarahi, Lida; Zakerian, Mohsen

2016-01-01

Introduction To supply quality services and healthcare, it is evident that medical ethics and patients’ rights, while providing medical and healthcare services need to be observed. This study was conducted to evaluate observance of the Patients’ Rights Charter among medical staff of educational hospitals affiliated to Mashhad University of Medical Sciences. Methods This cross-sectional study was conducted in four educational hospitals in Mashhad on eighty physicians, nurses, nurse aids and medical students. Data were collected using a two-part inventory of patients’ rights, including demographic data and inventory of patients’ rights observance. Data analysis was conducted using SPSS-16 as well as descriptive statistics, independent t-test, chi-square, Spearman correlation coefficient and Pearson correlation. Results Mean age of subjects was 36.3±8.3. Observance of human rights was perfect by 84.4 percent of subjects. The highest amount of observance of patients’ rights was related to the area of respecting patients’ privacy and observing the principle of confidentiality, which was evaluated to be perfect by all subjects (100%). The lowest value of patients’ rights observance was related to presenting appropriate and adequate information for patients, which was perfect among 48.1% of subjects. There was no significant relation between personal details (age, gender, education and career) and observance of patients’ rights (p>0.05). Conclusion Although in this study, the observance of patients’ rights by medical staff is optimal in most areas, the area of providing appropriate and adequate information needs to be promoted. Therefore, it is suggested that more stringent regulatory policies be compiled and implemented to the items of Patients’ Rights Charter along with training courses, to strengthen medical staff’s awareness in this regard. PMID:27957310

Evaluation on surface current observing network of high frequency ground wave radars in the Gulf of Thailand

NASA Astrophysics Data System (ADS)

Yin, Xunqiang; Shi, Junqiang; Qiao, Fangli

2018-05-01

Due to the high cost of ocean observation system, the scientific design of observation network becomes much important. The current network of the high frequency radar system in the Gulf of Thailand has been studied using a three-dimensional coastal ocean model. At first, the observations from current radars have been assimilated into this coastal model and the forecast results have improved due to the data assimilation. But the results also show that further optimization of the observing network is necessary. And then, a series of experiments were carried out to assess the performance of the existing high frequency ground wave radar surface current observation system. The simulated surface current data in three regions were assimilated sequentially using an efficient ensemble Kalman filter data assimilation scheme. The experimental results showed that the coastal surface current observation system plays a positive role in improving the numerical simulation of the currents. Compared with the control experiment without assimilation, the simulation precision of surface and subsurface current had been improved after assimilated the surface currents observed at current networks. However, the improvement for three observing regions was quite different and current observing network in the Gulf of Thailand is not effective and a further optimization is required. Based on these evaluations, a manual scheme has been designed by discarding the redundant and inefficient locations and adding new stations where the performance after data assimilation is still low. For comparison, an objective scheme based on the idea of data assimilation has been obtained. Results show that all the two schemes of observing network perform better than the original network and optimal scheme-based data assimilation is much superior to the manual scheme that based on the evaluation of original observing network in the Gulf of Thailand. The distributions of the optimal network of radars could be a useful guidance for future design of observing system in this region.

[Evaluation of the surface of the new intraocular lenses in the scanning electron microscope].

PubMed

Kałuzny, B J; Szatkowski, J; Kałuzny, J J

2001-01-01

To evaluate the surface of the new PC IOLs commercially available in Poland in 2000. Representative samples of new posterior chamber IOLs produced by 6 different companies (Alcon, Lensita, Medicontur, Opsia, Rayner, Storz), 5 of each, underwent surface examination with Novoscan 30 scanning electron microscope. Although, in general, smooth surface of optic and haptic parts were observed, three samples with irregularities were found. Comparing to previous evaluation performed in 1994, significant improvement in quality of IOLs surface was noted. No considerable differences in this field between above mentioned producers were observed.

Process perspective on image quality evaluation

NASA Astrophysics Data System (ADS)

Leisti, Tuomas; Halonen, Raisa; Kokkonen, Anna; Weckman, Hanna; Mettänen, Marja; Lensu, Lasse; Ritala, Risto; Oittinen, Pirkko; Nyman, Göte

2008-01-01

The psychological complexity of multivariate image quality evaluation makes it difficult to develop general image quality metrics. Quality evaluation includes several mental processes and ignoring these processes and the use of a few test images can lead to biased results. By using a qualitative/quantitative (Interpretation Based Quality, IBQ) methodology, we examined the process of pair-wise comparison in a setting, where the quality of the images printed by laser printer on different paper grades was evaluated. Test image consisted of a picture of a table covered with several objects. Three other images were also used, photographs of a woman, cityscape and countryside. In addition to the pair-wise comparisons, observers (N=10) were interviewed about the subjective quality attributes they used in making their quality decisions. An examination of the individual pair-wise comparisons revealed serious inconsistencies in observers' evaluations on the test image content, but not on other contexts. The qualitative analysis showed that this inconsistency was due to the observers' focus of attention. The lack of easily recognizable context in the test image may have contributed to this inconsistency. To obtain reliable knowledge of the effect of image context or attention on subjective image quality, a qualitative methodology is needed.

OSSE Evaluation of Prospective Aircraft Reconnaissance Flight Patterns and their Impact on Hurricane Forecasts

NASA Astrophysics Data System (ADS)

Ryan, K. E.; Bucci, L. R.; Christophersen, H.; Atlas, R. M.; Murillo, S.; Dodge, P.

2015-12-01

Each year, NOAA/AOML's Hurricane Research Division (HRD) conducts its Hurricane field Program in which observations are collected via NOAA aircraft to improve the understanding and prediction of hurricanes. Mission experiments suggest a variety of flight patterns and sampling strategies aimed towards their respective goals described by the Intensity Forecasting Experiment (IFEX; Rogers et al., BAMS, 2006, 2013), a collaborative effort among HRD, NHC, and EMC. Evaluating the potential impact of various trade-offs in design is valuable for determining the optimal air reconnaissance flight pattern for a given prospective mission. AOML's HRD has developed a system for performing regional Observing System Simulation Experiments (OSSEs) to assess the potential impact of proposed observing systems on hurricane track and intensity forecasts and analyses. This study focuses on investigating the potential impact of proposed aircraft reconnaissance observing system designs. Aircraft instrument and flight level retrievals were simulated from a regional WRF ARW Nature Run (Nolan et al., 2013) spanning 13 days, covering the life cycle of a rapidly intensifying Atlantic tropical cyclone. The aircraft trajectories are simulated in a variety of ways and are evaluated to investigate the potential impact of aircraft reconnaissance observations on hurricane track and intensity forecasts.

Effect of two X-ray tube voltages on detection of approximal caries in digital radiographs. An in vitro study.

PubMed

Hellén-Halme, Kristina

2011-04-01

This study evaluated the effect of two different tube voltages on clinicians' ability to diagnose approximal carious lesions in digital radiographs. One hundred extracted teeth were radiographed twice at two voltage settings, 60 and 70 kV, using a standardized procedure. Seven observers evaluated the radiographs on a standard color monitor pre-calibrated according to DICOM part 14. Evaluations were made at ambient light levels below 50 lx. All observations were analyzed with receiver operating characteristic curves. A histological examination of the teeth served as the criterion standard. A paired t test compared the effects of the two voltages. The significance level was set to p < 0.05. Weighted kappa statistics estimated intra-observer agreement. No significant difference in accuracy of approximal carious lesion diagnosis was found between the two voltage settings. But five observers rated dentin lesions on radiographs exposed at 70 kV better than on radiographs exposed at 60 kV. Intra-observer agreement differed from fair to moderate. There was no significant difference in accuracy of approximal carious lesion diagnosis between digital radiographs exposed with 60 or 70 kV.

Measuring the quality of life and well-being of people with dementia: A review of observational measures.

PubMed

Algar, Katherine; Woods, Robert T; Windle, Gill

2016-07-01

The dynamic nature of psychosocial interventions implies that trying to measure their effects using standardised clinical trial measures may not capture their full effects. Rich and valuable data during the sessions may be missed by using standard quality of life questionnaires. This paper compares observational measures in the context of recording the well-being of a person with dementia during and outside of a visual arts intervention. A literature search was conducted using systematic principles of searching, screening and retrieval to identify peer-reviewed English language evaluations of research projects using observational measures with people with dementia. Psychometric properties, strengths and weaknesses of 11 observational tools are reviewed in order to identify the most appropriate one for evaluating a visual art intervention for people with dementia. This review supports the Greater Cincinnati Chapter Well-Being Observation Tool as an appropriate measure to evaluate a visual art programme for people with dementia. The results of this review will help researchers plan projects to show the full range of effects for people with dementia for taking part in art sessions. © The Author(s) 2014.

A Bayesian Approach to Evaluating Consistency between Climate Model Output and Observations

NASA Astrophysics Data System (ADS)

Braverman, A. J.; Cressie, N.; Teixeira, J.

2010-12-01

Like other scientific and engineering problems that involve physical modeling of complex systems, climate models can be evaluated and diagnosed by comparing their output to observations of similar quantities. Though the global remote sensing data record is relatively short by climate research standards, these data offer opportunities to evaluate model predictions in new ways. For example, remote sensing data are spatially and temporally dense enough to provide distributional information that goes beyond simple moments to allow quantification of temporal and spatial dependence structures. In this talk, we propose a new method for exploiting these rich data sets using a Bayesian paradigm. For a collection of climate models, we calculate posterior probabilities its members best represent the physical system each seeks to reproduce. The posterior probability is based on the likelihood that a chosen summary statistic, computed from observations, would be obtained when the model's output is considered as a realization from a stochastic process. By exploring how posterior probabilities change with different statistics, we may paint a more quantitative and complete picture of the strengths and weaknesses of the models relative to the observations. We demonstrate our method using model output from the CMIP archive, and observations from NASA's Atmospheric Infrared Sounder.

Climate Model Diagnostic and Evaluation: With a Focus on Satellite Observations

NASA Technical Reports Server (NTRS)

Waliser, Duane

2011-01-01

Each year, we host a summer school that brings together the next generation of climate scientists - about 30 graduate students and postdocs from around the world - to engage with premier climate scientists from the Jet Propulsion Laboratory and elsewhere. Our yearly summer school focuses on topics on the leading edge of climate science research. Our inaugural summer school, held in 2011, was on the topic of "Using Satellite Observations to Advance Climate Models," and enabled students to explore how satellite observations can be used to evaluate and improve climate models. Speakers included climate experts from both NASA and the National Oceanic and Atmospheric Administration (NOAA), who provided updates on climate model diagnostics and evaluation and remote sensing of the planet. Details of the next summer school will be posted here in due course.

Evaluation of aerodynamic derivatives from a magnetic balance system

NASA Technical Reports Server (NTRS)

Raghunath, B. S.; Parker, H. M.

1972-01-01

The dynamic testing of a model in the University of Virginia cold magnetic balance wind-tunnel facility is expected to consist of measurements of the balance forces and moments, and the observation of the essentially six degree of freedom motion of the model. The aerodynamic derivatives of the model are to be evaluated from these observations. The basic feasibility of extracting aerodynamic information from the observation of a model which is executing transient, complex, multi-degree of freedom motion is demonstrated. It is considered significant that, though the problem treated here involves only linear aerodynamics, the methods used are capable of handling a very large class of aerodynamic nonlinearities. The basic considerations include the effect of noise in the data on the accuracy of the extracted information. Relationships between noise level and the accuracy of the evaluated aerodynamic derivatives are presented.

Solar Eclipse Effect on Shelter Air Temperature

NASA Technical Reports Server (NTRS)

Segal, M.; Turner, R. W.; Prusa, J.; Bitzer, R. J.; Finley, S. V.

1996-01-01

Decreases in shelter temperature during eclipse events were quantified on the basis of observations, numerical model simulations, and complementary conceptual evaluations. Observations for the annular eclipse on 10 May 1994 over the United States are presented, and these provide insights into the temporal and spatial changes in the shelter temperature. The observations indicated near-surface temperature drops of as much as 6 C. Numerical model simulations for this eclipse event, which provide a complementary evaluation of the spatial and temporal patterns of the temperature drops, predict similar decreases. Interrelationships between the temperature drop, degree of solar irradiance reduction, and timing of the peak eclipse are also evaluated for late spring, summer, and winter sun conditions. These simulations suggest that for total eclipses the drops in shelter temperature in midlatitudes can be as high as 7 C for a spring morning eclipse.

Electronic evaluation for video commercials by impression index.

PubMed

Kong, Wanzeng; Zhao, Xinxin; Hu, Sanqing; Vecchiato, Giovanni; Babiloni, Fabio

2013-12-01

How to evaluate the effect of commercials is significantly important in neuromarketing. In this paper, we proposed an electronic way to evaluate the influence of video commercials on consumers by impression index. The impression index combines both the memorization and attention index during consumers observing video commercials by tracking the EEG activity. It extracts features from scalp EEG to evaluate the effectiveness of video commercials in terms of time-frequency-space domain. And, the general global field power was used as an impression index for evaluation of video commercial scenes as time series. Results of experiment demonstrate that the proposed approach is able to track variations of the cerebral activity related to cognitive task such as observing video commercials, and help to judge whether the scene in video commercials is impressive or not by EEG signals.

Towards Designing an Integrated Architecture for NEO Characterization, Mitigation, Scientific Evaluation, and Resource Utilization

NASA Technical Reports Server (NTRS)

Adams, Robert B.; LaPointe, Michael; Wilks, Rod; Allen, Brian

2009-01-01

This poster reviews the planning and design for an integrated architecture for characterization, mitigation, scientific evaluation and resource utilization of near earth objects. This includes tracks to observe and characterize the nature of the threat posed by a NEO, and deflect if a significant threat is posed. The observation stack can also be used for a more complete scientific analysis of the NEO.

Correlation analysis between 2D and quasi-3D gamma evaluations for both intensity-modulated radiation therapy and volumetric modulated arc therapy

PubMed Central

Kim, Jung-in; Choi, Chang Heon; Wu, Hong-Gyun; Kim, Jin Ho; Kim, Kyubo; Park, Jong Min

2017-01-01

The aim of this work was to investigate correlations between 2D and quasi-3D gamma passing rates. A total of 20 patients (10 prostate cases and 10 head and neck cases, H&N) were retrospectively selected. For each patient, both intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans were generated. For each plan, 2D gamma evaluation with radiochromic films and quasi-3D gamma evaluation with fluence measurements were performed with both 2%/2 mm and 3%/3 mm criteria. Gamma passing rates were grouped together according to delivery techniques and treatment sites. Statistical analyses were performed to examine the correlation between 2D and quasi-3D gamma evaluations. Statistically significant difference was observed between delivery techniques only in the quasi-3D gamma passing rates with 2%/2 mm. Statistically significant differences were observed between treatment sites in the 2D gamma passing rates (differences of less than 8%). No statistically significant correlations were observed between 2D and quasi-3D gamma passing rates except the VMAT group and the group including both IMRT and VMAT with 3%/3 mm (r = 0.564 with p = 0.012 for theVMAT group and r = 0.372 with p = 0.020 for the group including both IMRT and VMAT), however, those were not strong. No strong correlations were observed between 2D and quasi-3D gamma evaluations. PMID:27690300

Solubility and bacterial sealing ability of MTA and root-end filling materials.

PubMed

Espir, Camila Galletti; Guerreiro-Tanomaru, Juliane Maria; Spin-Neto, Rubens; Chávez-Andrade, Gisselle Moraima; Berbert, Fabio Luiz Camargo Villela; Tanomaru-Filho, Mario

2016-04-01

Objective To evaluate solubility and sealing ability of Mineral Trioxide Aggregate (MTA) and root-end filling materials. Material and Methods The materials evaluated were: MTA, Calcium Silicate Cement with zirconium oxide (CSC/ZrO2), and zinc oxide/eugenol (ZOE). Solubility test was performed according to ANSI/ADA. The difference between initial and final mass of the materials was analyzed after immersion in distilled water for 7 and 30 days. Retrograde cavities in human teeth with single straight root canal were performed by using ultrasonic tip CVD 9.5107-8. The cavities were filled with the evaluated materials to evaluate sealing ability using the bacterial leakage test with Enterococcus faecalis. Bacterial leakage was evaluated every 24 hours for six weeks observing the turbidity of Brain Heart infusion (BHI) medium in contact with root apex. Data were submitted to ANOVA followed by Tukey tests (solubility), and Kruskal-Wallis and Dunn tests (sealing ability) at a 5% significance level. Results For the 7-day period, ZOE presented highest solubility when compared with the other groups (p<0.05). For the 30-day period, no difference was observed among the materials. Lower bacterial leakage was observed for MTA and CSC/ZrO2, and both presented better results than ZOE (p<0.05). Conclusion MTA and CSC/ZrO2 presented better bacterial sealing capacity, which may be related to lower initial solubility observed for these materials in relation to ZOE.

Statistical Evaluation of CRM-Simulated Cloud and Precipitation Structures Using Multi- sensor TRMM Measurements and Retrievals

NASA Astrophysics Data System (ADS)

Posselt, D.; L'Ecuyer, T.; Matsui, T.

2009-05-01

Cloud resolving models are typically used to examine the characteristics of clouds and precipitation and their relationship to radiation and the large-scale circulation. As such, they are not required to reproduce the exact location of each observed convective system, much less each individual cloud. Some of the most relevant information about clouds and precipitation is provided by instruments located on polar-orbiting satellite platforms, but these observations are intermittent "snapshots" in time, making assessment of model performance challenging. In contrast to direct comparison, model results can be evaluated statistically. This avoids the requirement for the model to reproduce the observed systems, while returning valuable information on the performance of the model in a climate-relevant sense. The focus of this talk is a model evaluation study, in which updates to the microphysics scheme used in a three-dimensional version of the Goddard Cumulus Ensemble (GCE) model are evaluated using statistics of observed clouds, precipitation, and radiation. We present the results of multiday (non-equilibrium) simulations of organized deep convection using single- and double-moment versions of a the model's cloud microphysical scheme. Statistics of TRMM multi-sensor derived clouds, precipitation, and radiative fluxes are used to evaluate the GCE results, as are simulated TRMM measurements obtained using a sophisticated instrument simulator suite. We present advantages and disadvantages of performing model comparisons in retrieval and measurement space and conclude by motivating the use of data assimilation techniques for analyzing and improving model parameterizations.

Obs4MIPS: Satellite Observations for Model Evaluation

NASA Astrophysics Data System (ADS)

Ferraro, R.; Waliser, D. E.; Gleckler, P. J.

2017-12-01

This poster will review the current status of the obs4MIPs project, whose purpose is to provide a limited collection of well-established and documented datasets for comparison with Earth system models (https://www.earthsystemcog.org/projects/obs4mips/). These datasets have been reformatted to correspond with the CMIP5 model output requirements, and include technical documentation specifically targeted for their use in model output evaluation. The project holdings now exceed 120 datasets with observations that directly correspond to CMIP5 model output variables, with new additions in response to the CMIP6 experiments. With the growth in climate model output data volume, it is increasing more difficult to bring the model output and the observations together to do evaluations. The positioning of the obs4MIPs datasets within the Earth System Grid Federation (ESGF) allows for the use of currently available and planned online tools within the ESGF to perform analysis using model output and observational datasets without necessarily downloading everything to a local workstation. This past year, obs4MIPs has updated its submission guidelines to closely align with changes in the CMIP6 experiments, and is implementing additional indicators and ancillary data to allow users to more easily determine the efficacy of an obs4MIPs dataset for specific evaluation purposes. This poster will present the new guidelines and indicators, and update the list of current obs4MIPs holdings and their connection to the ESGF evaluation and analysis tools currently available, and being developed for the CMIP6 experiments.

Dynamic evaluation of two decades of WRF-CMAQ ozone ...

EPA Pesticide Factsheets

Dynamic evaluation of the fully coupled Weather Research and Forecasting (WRF)– Community Multi-scale Air Quality (CMAQ) model ozone simulations over the contiguous United States (CONUS) using two decades of simulations covering the period from 1990 to 2010 is conducted to assess how well the changes in observed ozone air quality are simulated by the model. The changes induced by variations in meteorology and/or emissions are also evaluated during the same timeframe using spectral decomposition of observed and modeled ozone time series with the aim of identifying the underlying forcing mechanisms that control ozone exceedances and making informed recommendations for the optimal use of regional-scale air quality models. The evaluation is focused on the warm season's (i.e., May–September) daily maximum 8-hr (DM8HR) ozone concentrations, the 4th highest (4th) and average of top 10 DM8HR ozone values (top10), as well as the spectrally-decomposed components of the DM8HR ozone time series using the Kolmogorov-Zurbenko (KZ) filter. Results of the dynamic evaluation are presented for six regions in the U.S., consistent with the National Oceanic and Atmospheric Administration (NOAA) climatic regions. During the earlier 11-yr period (1990–2000), the simulated and observed trends are not statistically significant. During the more recent 2000–2010 period, all trends are statistically significant and WRF-CMAQ captures the observed trend in most regions. Given large n

Company observational post-marketing studies: drug risk assessment and drug research in special populations--a study-based analysis.

PubMed

Hasford, J; Lamprecht, T

1998-01-01

Company observational post-marketing studies (COPS) claim to provide essential data about drug risks and effectiveness in special populations not admitted to pre-approval clinical trials. Since COPS are often mainly regarded as a marketing activity, this study-based analysis tries to evaluate the scientific contributions of COPS. Thirty-five COPS were identified by hand-searching through medical journals, writing to pharmaceutical manufacturers and using MEDLINE. Fourteen COPS evaluated cardiovascular drugs, 9 evaluated NSAIDs and 12 evaluated various other indications. Thirty-five COPS listed effectiveness, 31 listed safety and 8 listed patient compliance as principal objectives. Not a single COPS included a control group. Seventeen of 21 evaluable COPS mentioned extensive exclusion criteria similar to those in clinical trials. Median observation time was 8 weeks, too short for chronic diseases and for adverse drug reactions with longer latency periods. One new adverse event was regarded. Global assessments of the outcomes by physicians dominated and were not based on objective clinical findings. None of the studies specified any details concerning the standardisation of observations or quality-control procedures. The current COPS scheme does not contribute significantly to our knowledge of drug safety and the effects in special populations. Despite serious criticism over the past 20 years, the poor quality of COPS compared with dramatic improvements of pre-approval trials - implies a need for detailed guidelines for non-experimental phase IV research, similar to the Good Clinical Practice-Guideline of the European Community.

The University of Colorado OSO-8 spectrometer experiment. IV - Mission operations

NASA Technical Reports Server (NTRS)

Hansen, E. R.; Bruner, E. C., Jr.

1979-01-01

The remote operation of two high-resolution ultraviolet spectrometers on the OSO-8 satellite is discussed. Mission operations enabled scientific observers to plan observations based on current solar data, interact with the observing program using real- or near real-time data and commands, evaluate quick-look instrument data, and analyze the observations for publication. During routine operations, experiments were planned a day prior to their execution, and the data from these experiments received a day later. When a shorter turnaround was required, a real-time mode was available. Here, the real-time data and command links into the remote control center were used to evaluate experiment operation and make satellite pointing or instrument configuration changes with a 1-90 minute turnaround.

Video Modeling and Observational Learning to Teach Gaming Access to Students with ASD.

PubMed

Spriggs, Amy D; Gast, David L; Knight, Victoria F

2016-09-01

The purpose of this study was to evaluate both video modeling and observational learning to teach age-appropriate recreation and leisure skills (i.e., accessing video games) to students with autism spectrum disorder. Effects of video modeling were evaluated via a multiple probe design across participants and criteria for mastery were based on these results. Secondary measures were collected on observational learning across participants and behaviors. Participants included 4 children with autism, ages 8-11, who were served in self-contained special education classrooms. Results indicated a functional relation between video modeling and increased independence in gaming; observational learning occurred for at least some steps across students. Results, implications for practitioners, limitations, and ideas for future research are discussed.

Can Principals Promote Teacher Development as Evaluators? A Case Study of Principals' Views and Experiences

ERIC Educational Resources Information Center

Kraft, Matthew A.; Gilmour, Allison F.

2016-01-01

Purpose: New teacher evaluation systems have expanded the role of principals as instructional leaders, but little is known about principals' ability to promote teacher development through the evaluation process. We conducted a case study of principals' perspectives on evaluation and their experiences implementing observation and feedback cycles to…

Secondary School Administrators' Perceptions of Louisiana's Compass System as a Framework for Teacher Evaluation

ERIC Educational Resources Information Center

Williams, Kathleen; Hebert, Dustin

2017-01-01

Louisiana's relatively new Compass teacher observation and evaluation system is used to evaluate teacher quality or effectiveness in P-12 public schools. Secondary school administrators in one district were interviewed about their perceptions of the system and, especially, an iteration of the Danielson rubric used for teacher evaluation. Findings…

Toward Meaningful Evaluation of Medical Trainees: The Influence of Participants' Perceptions of the Process

ERIC Educational Resources Information Center

Watling, Christopher J.; Lingard, Lorelei

2012-01-01

An essential goal of evaluation is to foster learning. Across the medical education spectrum, evaluation of clinical performance is dominated by subjective feedback to learners based on observation by expert supervisors. Research in non-medical settings has suggested that participants' perceptions of evaluation processes exert considerable…

Tropical convection regimes in climate models: evaluation with satellite observations

NASA Astrophysics Data System (ADS)

Steiner, Andrea K.; Lackner, Bettina C.; Ringer, Mark A.

2018-04-01

High-quality observations are powerful tools for the evaluation of climate models towards improvement and reduction of uncertainty. Particularly at low latitudes, the most uncertain aspect lies in the representation of moist convection and interaction with dynamics, where rising motion is tied to deep convection and sinking motion to dry regimes. Since humidity is closely coupled with temperature feedbacks in the tropical troposphere, a proper representation of this region is essential. Here we demonstrate the evaluation of atmospheric climate models with satellite-based observations from Global Positioning System (GPS) radio occultation (RO), which feature high vertical resolution and accuracy in the troposphere to lower stratosphere. We focus on the representation of the vertical atmospheric structure in tropical convection regimes, defined by high updraft velocity over warm surfaces, and investigate atmospheric temperature and humidity profiles. Results reveal that some models do not fully capture convection regions, particularly over land, and only partly represent strong vertical wind classes. Models show large biases in tropical mean temperature of more than 4 K in the tropopause region and the lower stratosphere. Reasonable agreement with observations is given in mean specific humidity in the lower to mid-troposphere. In moist convection regions, models tend to underestimate moisture by 10 to 40 % over oceans, whereas in dry downdraft regions they overestimate moisture by 100 %. Our findings provide evidence that RO observations are a unique source of information, with a range of further atmospheric variables to be exploited, for the evaluation and advancement of next-generation climate models.

The clinical experience and efficacy of bipolar radiofrequency with fractional photothermolysis for aged Asian skin.

PubMed

Akita, Hirotaka; Sasaki, Ryosuke; Yokoyama, Yusuke; Negishi, Kei; Matsunaga, Kayoko

2014-10-01

Bipolar radiofrequency (RF) technology is developed based on fractional thermolysis, and the literature concerning the efficacy of the rejuvenation and treatment of acne scars has been reported in Europe and the United States of America. Therefore, we examined bipolar RF treatment using fractional thermolysis to evaluate the efficacy and safety of the treatment of Asian photo-aging skin, particularly 'wrinkles' and 'sagging.' Ten Japanese women (mean age: 58.6, skin type III-IV) received three fractional bipolar RF treatments every 4-6 weeks. For the objective evaluation, we evaluated the improvement of the wrinkles on the forehead, lateral canthus (crow's feet) and lower eyelid, and the sagging of the nasolabial fold using digital photographs captured using Visia(™) . For the subjective evaluation, the participants were asked to describe the improvements observed in the wrinkles on the forehead, lateral canthus (crow's feet) and lower eyelid, and sagging nasolabial fold and to evaluate the level pain experienced using a 10-point VAS score. The objective evaluation in each category showed significant improvements in the wrinkles on the lateral canthus (crow's feet) and lower eyelid. As for the nasolabial fold, 60% of the subjects showed improvements, scoring from good to excellent (51-100% improvement), although there was a little improvement of the wrinkle on the forehead. Similar improvements were observed in the subjective evaluation. During each treatment, oedema and erythema were observed in all participants, but the oedema disappeared the following day in all cases. However, mild erythema persisted for an average of 3.1 days. Micro debris disappeared after an average of 5.2 days. The participants were satisfied, as we allowed them to apply make-up the next day. There were no other severe adverse reactions observed during the treatment. The 10-point VAS score was 3.8, and no participants dropped out due to discomfort. Little improvement was observed in the forehead wrinkles in either the objective or the subjective evaluation. The results obtained in this study indicate that fractional bipolar RF is an effective and safe treatment for the 'wrinkling' and 'sagging' of Asian photo-aging skin. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Accounting for observational uncertainties in the evaluation of low latitude turbulent air-sea fluxes simulated in a suite of IPSL model versions

NASA Astrophysics Data System (ADS)

Servonnat, Jerome; Braconnot, Pascale; Gainusa-Bogdan, Alina

2015-04-01

Turbulent momentum and heat (sensible and latent) fluxes at the air-sea interface are key components of the whole energetic of the Earth's climate and their good representation in climate models is of prime importance. In this work, we use the methodology developed by Braconnot & Frankignoul (1993) to perform a Hotelling T2 test on spatio-temporal fields (annual cycles). This statistic provides a quantitative measure accounting for an estimate of the observational uncertainty for the evaluation of low-latitude turbulent air-sea fluxes in a suite of IPSL model versions. The spread within the observational ensemble of turbulent flux data products assembled by Gainusa-Bogdan et al (submitted) is used as an estimate of the observational uncertainty for the different turbulent fluxes. The methodology holds on a selection of a small number of dominating variability patterns (EOFs) that are common to both the model and the observations for the comparison. Consequently it focuses on the large-scale variability patterns and avoids the possibly noisy smaller scales. The results show that different versions of the IPSL couple model share common large scale model biases, but also that there the skill on sea surface temperature is not necessarily directly related to the skill in the representation of the different turbulent fluxes. Despite the large error bars on the observations the test clearly distinguish the different merits of the different model version. The analyses of the common EOF patterns and related time series provide guidance on the major differences with the observations. This work is a first attempt to use such statistic on the evaluation of the spatio-temporal variability of the turbulent fluxes, accounting for an observational uncertainty, and represents an efficient tool for systematic evaluation of simulated air-seafluxes, considering both the fluxes and the related atmospheric variables. References Braconnot, P., and C. Frankignoul (1993), Testing Model Simulations of the Thermocline Depth Variability in the Tropical Atlantic from 1982 through 1984, J. Phys. Oceanogr., 23(4), 626-647 Gainusa-Bogdan A., Braconnot P. and Servonnat J. (submitted), Using an ensemble data set of turbulent air-sea fluxes to evaluate the IPSL climate model in tropical regions, Journal of Geophysical Research Atmosphere, 2014JD022985

Evaluating Earth and Space Sciences STEM Research Communication in 7th-12th Grade Rural Mississippi Classrooms and Resulting Student Attitudinal Impacts

NASA Astrophysics Data System (ADS)

Radencic, S.; McNeal, K. S.

2013-05-01

Observation and evaluation of STEM graduate students from Mississippi State University communicating their research of the Earth and Space Sciences in rural 7th-12th grade classrooms participating in the Initiating New Science Partnerships in Rural Education (INSPIRE) NSF GK-12 project. The methods they utilize to communicate their STEM research includes introducing new technologies and inquiry based learning experiences. These communication experiences have been observed and evaluated using two observational systems, the Mathematics Science Classroom Observational Profile System (M-SCOPS) and the Presentation Skills Protocol (PSP). M-SCOPS has been used over the first three years of the project to evaluate what Earth and Space research the STEM graduate students communicate in classroom activities along with how they are introducing STEM research through a variety of communication methods and levels of understanding. PSP, which INSPIRE began using this year, evaluates and provides feedback to the STEM graduate students on their communication during these classroom experiences using a rubric covering a range of skills for successful communication. PSP also allows the participating INSPIRE teacher partners to provide feedback to the STEM graduate students about development of their communication skills over the course of the year. In addition to feedback from the INSPIRE project and participating teachers, the STEM graduate students have the opportunity to evaluate their personal communication skills through video documentation to determine specific skills they would like to improve. Another area of research to be discussed is how the STEM graduate students communicating Earth and Space sciences research in the participating classrooms is impacting student attitudes about science and mathematics over the last three years. Student Attitudinal Surveys (SAS) are administered as a pre-evaluation tool in the fall when the STEM graduate students first enter into their partner classrooms and again each spring for post-evaluation before the STEM graduate students depart from the classrooms. An evaluation of graduate communication effectiveness will be related to the 7th-12th grade student attitudes about science and mathematics.

These Strategies Soothe the Sting of Teacher Evaluation.

ERIC Educational Resources Information Center

Alkire, Phil

1990-01-01

When conducting teacher evaluations, the wise principal acts within union contracts and board policies, asks teachers for self-evaluations, carefully plans classroom visits, observes correctly, takes accurate notes, considers videotaping teachers, deemphasizes ratings, makes postevaluation conferences meaningful, and offers teachers a chance for…

Social worker assessment of bad news delivery by emergency medicine residents: a novel direct-observation milestone assessment.

PubMed

Min, Alice Ann; Spear-Ellinwood, Karen; Berman, Melissa; Nisson, Peyton; Rhodes, Suzanne Michelle

2016-09-01

The skill of delivering bad news is difficult to teach and evaluate. Residents may practice in simulated settings; however, this may not translate to confidence or competence during real experiences. We investigated the acceptability and feasibility of social workers as evaluators of residents' delivery of bad news during patient encounters, and assessed the attitudes of both groups regarding this process. From August 2013 to June 2014, emergency medicine residents completed self-assessments after delivering bad news. Social workers completed evaluations after observing these conversations. The Assessment tools were designed by modifying the global Breaking Bad News Assessment Scale. Residents and social workers completed post-study surveys. 37 evaluations were received, 20 completed by social workers and 17 resident self-evaluations. Social workers reported discussing plans with residents prior to conversations 90 % of the time (18/20, 95 % CI 64.5, 97.8). Social workers who had previously observed the resident delivering bad news reported that the resident was more skilled on subsequent encounters 90 % of the time (95 % CI 42.2, 99). Both social workers and residents felt that prior training or experience was important. First-year residents valued advice from social workers less than advice from attending physicians, whereas more experienced residents perceived advice from social workers to be equivalent with that of attending physicians (40 versus 2.9 %, p = 0.002). Social worker assessment of residents' abilities to deliver bad news is feasible and acceptable to both groups. This formalized self-assessment and evaluation process highlights the importance of social workers' involvement in delivery of bad news, and the teaching of this skill. This method may also be used as direct-observation for resident milestone assessment.

Reliability and reproducibility of disc-foveal angle measurements by non-mydriatic fundus photography.

PubMed

Le Jeune, Caroline; Chebli, Fayçal; Leon, Lorette; Anthoine, Emmanuelle; Weber, Michel; Péchereau, Alain; Lebranchu, Pierre

2018-01-01

Abnormal torsion could be associated with cyclovertical strabismus, but torsion measurements are not reliable in children. To assess an objective fundus torsion evaluation in a paediatric population, we used Non-Mydriatic Fundus photography (NMFP) in healthy and cyclovertical strabismus patients to evaluate the disc-foveal angle over time and observers. We used a retrospective set of NMFP including 24 A or V-pattern strabismus and 27 age-matched normal children (mean age 6.4 and 6.7 years respectively), taken during 2 distinct follow-up consultations (separated by 251 and 479 days respectively). Each disc-foveal angle measurement (from which the ocular torsion can be assessed) was performed by 5 different observers, using graphical software and based on reproducible fundus anatomical marks. Statistical analysis was performed with a multivariate ANOVA using group, time and observers as factors, in addition to intraclass coefficient correlation (ICC) to assess measurement reproducibility. A significant difference of disc-foveal angle measures was observed between groups (p<0,001): 18.73° (SD = 6.42), -3,25° (SD = 5.51) and 6,89° (SD = 4,41) respectively for V-pattern, A- pattern and normal subjects. Neither observers (F = 0,2028 p = 0,9369) nor time between 1st and 2nd NMFP (F = 0,6312 p = 0,4271) seem to influence the measure of disc-foveal angle. The evaluation of disc-foveal angle was very reproducible between observers (ICC>0,97). Abnormal amount of objective torsion could be associated with alphabet-pattern strabismus. Disc-foveal angle evaluation by NMFP in a children population appears as a non-invasive, reliable and reproducible method.

Effects of uncertainties in hydrological modelling. A case study of a mountainous catchment in Southern Norway

NASA Astrophysics Data System (ADS)

Engeland, Kolbjørn; Steinsland, Ingelin; Johansen, Stian Solvang; Petersen-Øverleir, Asgeir; Kolberg, Sjur

2016-05-01

In this study, we explore the effect of uncertainty and poor observation quality on hydrological model calibration and predictions. The Osali catchment in Western Norway was selected as case study and an elevation distributed HBV-model was used. We systematically evaluated the effect of accounting for uncertainty in parameters, precipitation input, temperature input and streamflow observations. For precipitation and temperature we accounted for the interpolation uncertainty, and for streamflow we accounted for rating curve uncertainty. Further, the effects of poorer quality of precipitation input and streamflow observations were explored. Less information about precipitation was obtained by excluding the nearest precipitation station from the analysis, while reduced information about the streamflow was obtained by omitting the highest and lowest streamflow observations when estimating the rating curve. The results showed that including uncertainty in the precipitation and temperature inputs has a negligible effect on the posterior distribution of parameters and for the Nash-Sutcliffe (NS) efficiency for the predicted flows, while the reliability and the continuous rank probability score (CRPS) improves. Less information in precipitation input resulted in a shift in the water balance parameter Pcorr, a model producing smoother streamflow predictions, giving poorer NS and CRPS, but higher reliability. The effect of calibrating the hydrological model using streamflow observations based on different rating curves is mainly seen as variability in the water balance parameter Pcorr. When evaluating predictions, the best evaluation scores were not achieved for the rating curve used for calibration, but for rating curves giving smoother streamflow observations. Less information in streamflow influenced the water balance parameter Pcorr, and increased the spread in evaluation scores by giving both better and worse scores.

Prevention of cognitive and physical decline by enjoyable walking-habituation program based on brain-activating rehabilitation.

PubMed

Murai, Tatsuhiko; Yamaguchi, Tomoharu; Maki, Yohko; Isahai, Mikie; Kaiho Sato, Ayumi; Yamagami, Tetsuya; Ura, Chiaki; Miyamae, Fumiko; Takahashi, Ryutaro; Yamaguchi, Haruyasu

2016-06-01

Evaluating effects of an enjoyable walking-habituation program. We carried out a 12-week intervention, consisting of an enjoyable walking-habituation program based on five principles of brain-activating rehabilitation: pleasant atmosphere, interactive communication, social roles, praising each other and errorless support. The program, once a week for 90 min, was carried out in small groups. Participants were 71 community-dwelling people (72.2 ± 4.3) without dementia. Cognitive function was evaluated in five cognitive domains: memory, executive function, word fluency, visuospatial abilities and sustained attention. Additionally, quality of life, depressive state, functional capacity, range of activities, social network and subjective memory complaints were assessed using questionnaires. Motor function was also evaluated. Measurement was carried out before the observation period, after observation and after intervention. A total of 63 participants were included in the analysis. Daily steps, executive function, subjective memory complaints, functional capacity and 5-m maximum walking time significantly improved during the intervention period (after observation to after intervention) compared with the observation period (before the observation period to after observation). No significant differences were seen in other evaluations. At 6 months after the intervention, 52 of 63 participants (82.5%) continued to walk once a week or more, and all of them were confident about continuing to walk in the future. Furthermore, all participants were satisfied with our walking-habituation program and all replied that they felt delighted. The intervention program, based on the five principles of brain-activating rehabilitation, resulted in improvement of some cognitive and physical functions, as well as a high walking-habituation rate at 6 months' follow up. Geriatr Gerontol Int 2015; ●●: ●●-●●. © 2015 Japan Geriatrics Society.

Reliability and Validity of Observational Risk Screening in Evaluating Dynamic Knee Valgus

PubMed Central

Ekegren, Christina L.; Miller, William C.; Celebrini, Richard G.; Eng, Janice J.; MacIntyre, Donna L.

2012-01-01

Study Design Nonexperimental methodological study. Objectives To determine the interrater and intrarater reliability and validity of using observational risk screening guidelines to evaluate dynamic knee valgus. Background A deficiency in the neuromuscular control of the hip has been identified as a key risk factor for non-contact anterior cruciate ligament (ACL) injury in post pubescent females. This deficiency can manifest itself as a valgus knee alignment during tasks involving hip and knee flexion. There are currently no scientifically tested methods to screen for dynamic knee valgus in the clinic or on the field. Methods Three physiotherapists used observational risk screening guidelines to rate 40 adolescent female soccer players according to their risk of ACL injury. The rating was based on the amount of dynamic knee valgus observed on a drop jump landing. Ratings were evaluated for intrarater and interrater agreement using kappa coefficients. Sensitivity and specificity of ratings were evaluated by comparing observational ratings with measurements obtained using 3-dimensional (3D) motion analysis. Results Kappa coefficients for intrarater and interrater agreement ranged from 0.75 to 0.85, indicating that ratings were reasonably consistent over time and between physiotherapists. Sensitivity values were inadequate, ranging from 67–87%. This indicated that raters failed to detect up to a third of “truly high risk” individuals. Specificity values ranged from 60–72% which was considered adequate for the purposes of the screen. Conclusion Observational risk screening is a practical and cost-effective method of screening for ACL injury risk. Rater agreement and specificity were acceptable for this method but sensitivity was not. To detect a greater proportion of individuals at risk of ACL injury, coaches and clinicians should ensure that they include additional tests for other high risk characteristics in their screening protocols. PMID:19721212

A general enhancement of autonomic and cortisol responses during social evaluative threat

PubMed Central

Bosch, Jos A.; de Geus, Eco J.C.; Carroll, Douglas; Goedhart, Annebet D.; Anane, Leila A.; van Zanten, Jet J Veldhuizen; Helmerhorst, Eva J.; Edwards, Kate M.

2013-01-01

Objective The idea that distinct psychosocial factors may underlie specific patterns of neuroendocrine stress responses has been a topic of recurrent debate. We examined a recent contribution to this debate, the Social Self Preservation Theory, which predicts that stressors involving social evaluative threat (SET) characteristically activate the hypothalamic-pituitary-adrenal (HPA) axis. Methods Sixty-one healthy university students (31 females) performed a challenging speech task in one of three conditions that aimed to impose increasing levels of SET: performing the task alone (no social evaluation), with 1 evaluating observer, or with 4 evaluating observers. Indices of sympathetic (pre-ejection period) and parasympathetic (heart rate variability) cardiac drive were obtained by impedance- and electrocardiography. Salivary cortisol was used to index HPA activity. Questionnaires assessed affective responses. Results Affective responses (shame/embarrassment, anxiety, negative affect, and self-esteem), cortisol, heart rate, sympathetic, and parasympathetic activation all differentiated evaluative from non-evaluative task conditions (p<.001). The largest effect-sizes were observed for cardiac autonomic responses. Physiological reactivity increased in parallel with increasing audience size (p<.001). A rise in cortisol was predicted by sympathetic activation during the task (p<.001), but not by affective responses. Conclusion It would appear that SET determines the magnitude, rather than the pattern, of physiological activation. This potential to broadly perturb multiple physiological systems may help explain why social stress has been associated with a range of health outcomes. We propose a threshold-activation model as a physiological explanation for why engaging stressors, such as those involving social evaluation or uncontrollability, may appear to selectively induce cortisol release. PMID:19779143

Diagnostic value of DIAGNOdent in detecting caries under composite restorations of primary molars.

PubMed

Sichani, Ava Vali; Javadinejad, Shahrzad; Ghafari, Roshanak

2016-01-01

Direct observation cannot detect caries under restorations; therefore, the aim of this study was to compare the accuracy of radiographs and DIAGNOdent in detecting caries under restorations in primary teeth using histologic evaluation. A total of 74 previously extracted primary molars (37 with occlusal caries and 37 without caries) were used. Class 1 cavity preparations were made on each tooth by a single clinician and then the preparations were filled with composite resin. The accuracy of radiographs and DIAGNOdent in detecting caries was compared using histologic evaluation. The data were analyzed by SPSS version 21 using Chi-square, Mc Namara statistical tests and receiver operating characteristic curve. The significance was set at 0.05. The sensitivity and specificity for DIAGNOdent were 70.97 and 83.72, respectively. Few false negative results were observed, and the positive predictive value was high (+PV = 75.9) and the area under curve was more than 0.70 therefore making DIAGNOdenta great method for detecting caries (P = 0.0001). Two observers evaluated the radiographs and both observers had low sensitivity ( first observer: 48.39) (second observer: 51.61) and high specificity (both observers: 79.07). The +PV was lower than DIAGNOdent and the area under curve for both observers was less than 0.70. However, the difference between the two methods was not significant. DIAGNOdent showed a greater accuracy in detecting secondary caries under primary molar restorations, compared to radiographs. Although DIAGNOdent is an effective method for detecting caries under composite restorations, it is better to be used as an adjunctive method alongside other detecting procedures.

Advancing the discussion about systematic classroom behavioral observation, a product review of Tenny, J. (2010). eCOVE observation software. Pacific City, OR: eCOVE Software, LLC.

PubMed

Froiland, John Mark; Smith, Liana

2014-05-01

Applied child psychologists and behavioral consultants often use systematic behavioral observations to inform the psychological assessment and intervention development process for children referred for attention and hyperactivity problems. This article provides a review of the 2010 version of the eCOVE classroom observation software in terms of its utility in tracking the progress of children with attention and hyperactive behaviors and its use in evaluating teacher behaviors that may impede or promote children's attention and positive behavior. The eCOVE shows promise as an efficient tool for psychologists and behavioral consultants who want to evaluate the effects of interventions for children with symptoms of ADHD, ODD, mood disorders and learning disorders; however, some research-based improvements for future models are suggested. The reviewers also share their firsthand experience in using eCOVE to evaluate teacher and student behavior exhibited on a television show about teaching urban high school students and during a movie about an eccentric new kindergarten teacher. Rich examples are provided of using strategic behavioral observations to reveal how to improve the classroom environment so as to facilitate attention, motivation and positive behavior among youth. Broader implications for enhancing the use of systematic behavioral observations in the assessment of children and adolescents with attention disorders and related behavioral problems are discussed. Key issues are examined such as the use of behavioral observations during psychological consultation to prevent the previously found gender bias in referrals for ADHD. Using behavioral observations to enhance differential diagnosis is also discussed.

A general enhancement of autonomic and cortisol responses during social evaluative threat.

PubMed

Bosch, Jos A; de Geus, Eco J C; Carroll, Douglas; Goedhart, Annebet D; Anane, Leila A; van Zanten, Jet J Veldhuizen; Helmerhorst, Eva J; Edwards, Kate M

2009-10-01

To examine the Social Self Preservation Theory, which predicts that stressors involving social evaluative threat (SET) characteristically activate the hypothalamic-pituitary-adrenal (HPA) axis. The idea that distinct psychosocial factors may underlie specific patterns of neuroendocrine stress responses has been a topic of recurrent debate. Sixty-one healthy university students (n = 31 females) performed a challenging speech task in one of three conditions that aimed to impose increasing levels of SET: performing the task alone (no social evaluation), with one evaluating observer, or with four evaluating observers. Indices of sympathetic (preejection period) and parasympathetic (heart rate variability) cardiac drive were obtained by impedance- and electrocardiography. Salivary cortisol was used to index HPA activity. Questionnaires assessed affective responses. Affective responses (shame/embarrassment, anxiety, negative affect, and self-esteem), cortisol, heart rate, sympathetic and parasympathetic activation all differentiated evaluative from nonevaluative task conditions (p < .001). The largest effect sizes were observed for cardiac autonomic responses. Physiological reactivity increased in parallel with increasing audience size (p < .001). An increase in cortisol was predicted by sympathetic activation during the task (p < .001), but not by affective responses. It would seem that SET determines the magnitude, rather than the pattern, of physiological activation. This potential to perturb broadly multiple physiological systems may help explain why social stress has been associated with a range of health outcomes. We propose a threshold-activation model as a physiological explanation for why engaging stressors, such as those involving social evaluation or uncontrollability, may seem to induce selectively cortisol release.

Review: advances in in situ and satellite phenological observations in Japan

NASA Astrophysics Data System (ADS)

Nagai, Shin; Nasahara, Kenlo Nishida; Inoue, Tomoharu; Saitoh, Taku M.; Suzuki, Rikie

2016-04-01

To accurately evaluate the responses of spatial and temporal variation of ecosystem functioning (evapotranspiration and photosynthesis) and services (regulating and cultural services) to the rapid changes caused by global warming, we depend on long-term, continuous, near-surface, and satellite remote sensing of phenology over wide areas. Here, we review such phenological studies in Japan and discuss our current knowledge, problems, and future developments. In contrast with North America and Europe, Japan has been able to evaluate plant phenology along vertical and horizontal gradients within a narrow area because of the country's high topographic relief. Phenological observation networks that support scientific studies and outreach activities have used near-surface tools such as digital cameras and spectral radiometers. Differences in phenology among ecosystems and tree species have been detected by analyzing the seasonal variation of red, green, and blue digital numbers (RGB values) extracted from phenological images, as well as spectral reflectance and vegetation indices. The relationships between seasonal variations in RGB-derived indices or spectral characteristics and the ecological and CO2 flux measurement data have been well validated. In contrast, insufficient satellite remote-sensing observations have been conducted because of the coarse spatial resolution of previous datasets, which could not detect the heterogeneous plant phenology that results from Japan's complex topography and vegetation. To improve Japanese phenological observations, multidisciplinary analysis and evaluation will be needed to link traditional phenological observations with "index trees," near-surface and satellite remote-sensing observations, "citizen science" (observations by citizens), and results published on the Internet.

Observation chart design features affect the detection of patient deterioration: a systematic experimental evaluation.

PubMed

Christofidis, Melany J; Hill, Andrew; Horswill, Mark S; Watson, Marcus O

2016-01-01

To systematically evaluate the impact of several design features on chart-users' detection of patient deterioration on observation charts with early-warning scoring-systems. Research has shown that observation chart design affects the speed and accuracy with which abnormal observations are detected. However, little is known about the contribution of individual design features to these effects. A 2 × 2 × 2 × 2 mixed factorial design, with data-recording format (drawn dots vs. written numbers), scoring-system integration (integrated colour-based system vs. non-integrated tabular system) and scoring-row placement (grouped vs. separate) varied within-participants and scores (present vs. absent) varied between-participants by random assignment. 205 novice chart-users, tested between March 2011-March 2014, completed 64 trials where they saw real patient data presented on an observation chart. Each participant saw eight cases (four containing abnormal observations) on each of eight designs (which represented a factorial combination of the within-participants variables). On each trial, they assessed whether any of the observations were physiologically abnormal, or whether all observations were normal. Response times and error rates were recorded for each design. Participants responded faster (scores present and absent) and made fewer errors (scores absent) using drawn-dot (vs. written-number) observations and an integrated colour-based (vs. non-integrated tabular) scoring-system. Participants responded faster using grouped (vs. separate) scoring-rows when scores were absent, but separate scoring-rows when scores were present. Our findings suggest that several individual design features can affect novice chart-users' ability to detect patient deterioration. More broadly, the study further demonstrates the need to evaluate chart designs empirically. © 2015 John Wiley & Sons Ltd.

An Evaluation of Non-Formal Education in Ecuador. Volume 2: Overview and Evaluation Plan. Final Report.

ERIC Educational Resources Information Center

Laosa, Luis M.; And Others

As the second volume in a 4-volume evaluation report on the University of Massachusetts Non-Formal Education Project (UMass NFEP) in rural Ecuador, this volume details the evaluation design. Cited as basic to the evaluation design are questions which ask: (1) What kinds of effects (changes) can be observed? and (2) What are characteristics of the…

Toward improving hurricane forecasts using the JPL Tropical Cyclone Information System (TCIS): A framework to address the issues of Big Data

NASA Astrophysics Data System (ADS)

Hristova-Veleva, S. M.; Boothe, M.; Gopalakrishnan, S.; Haddad, Z. S.; Knosp, B.; Lambrigtsen, B.; Li, P.; montgomery, M. T.; Niamsuwan, N.; Tallapragada, V. S.; Tanelli, S.; Turk, J.; Vukicevic, T.

2013-12-01

Accurate forecasting of extreme weather requires the use of both regional models as well as global General Circulation Models (GCMs). The regional models have higher resolution and more accurate physics - two critical components needed for properly representing the key convective processes. GCMs, on the other hand, have better depiction of the large-scale environment and, thus, are necessary for properly capturing the important scale interactions. But how to evaluate the models, understand their shortcomings and improve them? Satellite observations can provide invaluable information. And this is where the issues of Big Data come: satellite observations are very complex and have large variety while model forecast are very voluminous. We are developing a system - TCIS - that addresses the issues of model evaluation and process understanding with the goal of improving the accuracy of hurricane forecasts. This NASA/ESTO/AIST-funded project aims at bringing satellite/airborne observations and model forecasts into a common system and developing on-line tools for joint analysis. To properly evaluate the models we go beyond the comparison of the geophysical fields. We input the model fields into instrument simulators (NEOS3, CRTM, etc.) and compute synthetic observations for a more direct comparison to the observed parameters. In this presentation we will start by describing the scientific questions. We will then outline our current framework to provide fusion of models and observations. Next, we will illustrate how the system can be used to evaluate several models (HWRF, GFS, ECMWF) by applying a couple of our analysis tools to several hurricanes observed during the 2013 season. Finally, we will outline our future plans. Our goal is to go beyond the image comparison and point-by-point statistics, by focusing instead on understanding multi-parameter correlations and providing robust statistics. By developing on-line analysis tools, our framework will allow for consistent model evaluation, providing results that are much more robust than those produced by case studies - the current paradigm imposed by the Big Data issues (voluminous data and incompatible analysis tools). We believe that this collaborative approach, with contributions of models, observations and analysis approaches used by the research and operational communities, will help untangle the complex interactions that lead to hurricane genesis and rapid intensity changes - two processes that still pose many unanswered questions. The developed framework for evaluation of the global models will also have implications for the improvement of the climate models, which output only a limited amount of information making it difficult to evaluate them. Our TCIS will help by investigating the GCMs under current weather scenarios and with much more detailed model output, making it possible to compare the models to multiple observed parameters to help narrow down the uncertainty in their performance. This knowledge could then be transferred to the climate models to lower the uncertainty in their predictions. The work described here was performed at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.

Inter-observer agreement improves with PERCIST 1.0 as opposed to qualitative evaluation in non-small cell lung cancer patients evaluated with F-18-FDG PET/CT early in the course of chemo-radiotherapy.

PubMed

Fledelius, Joan; Khalil, Azza; Hjorthaug, Karin; Frøkiær, Jørgen

2016-12-01

The purpose of this study is to determine whether a qualitative approach or a semi-quantitative approach provides the most robust method for early response evaluation with 2'-deoxy-2'-[(18)F]fluoro-D-glucose (F-18-FDG) positron emission tomography combined with whole body computed tomography (PET/CT) in non-small cell lung cancer (NSCLC). In this study eight Nuclear Medicine consultants analyzed F-18-FDG PET/CT scans from 35 patients with locally advanced NSCLC. Scans were performed at baseline and after 2 cycles of chemotherapy. Each observer used two different methods for evaluation: (1) PET response criteria in solid tumors (PERCIST) 1.0 and (2) a qualitative approach. Both methods allocate patients into one of four response categories (complete and partial metabolic response (CMR and PMR) and stable and progressive metabolic disease (SMD and PMD)). The inter-observer agreement was evaluated using Fleiss' kappa for multiple raters, Cohens kappa for comparison of the two methods, and intraclass correlation coefficients (ICC) for comparison of lean body mass corrected standardized uptake value (SUL) peak measurements. The agreement between observers when determining the percentage change in SULpeak was "almost perfect", with ICC = 0.959. There was a strong agreement among observers allocating patients to the different response categories with a Fleiss kappa of 0.76 (0.71-0.81). In 22 of the 35 patients, complete agreement was observed with PERCIST 1.0. The agreement was lower when using the qualitative method, moderate, having a Fleiss kappa of 0.60 (0.55-0.64). Complete agreement was achieved in only 10 of the 35 patients. The difference between the two methods was statistically significant (p < 0.005) (chi-squared). Comparing the two methods for each individual observer showed Cohen's kappa values ranging from 0.64 to 0.79, translating into a strong agreement between the two methods. PERCIST 1.0 provides a higher overall agreement between observers than the qualitative approach in categorizing early treatment response in NSCLC patients. The inter-observer agreement is in fact strong when using PERCIST 1.0 even when the level of instruction is purposely kept to a minimum in order to mimic the everyday situation. The variability is largely owing to the subjective elements of the method.

The social evaluation of faces: a meta-analysis of functional neuroimaging studies

PubMed Central

Mende-Siedlecki, Peter; Said, Christopher P.

2013-01-01

Neuroscience research on the social evaluation of faces has accumulated over the last decade, yielding divergent results. We used a meta-analytic technique, multi-level kernel density analysis (MKDA), to analyze 29 neuroimaging studies on face evaluation. Across negative face evaluations, we observed the most consistent activations in bilateral amygdala. Across positive face evaluations, we observed the most consistent activations in medial prefrontal cortex, pregenual anterior cingulate cortex (pgACC), medial orbitofrontal cortex (mOFC), left caudate and nucleus accumbens (NAcc). Based on additional analyses comparing linear and non-linear responses, we propose a ventral/dorsal dissociation within the amygdala, wherein separate populations of neurons code for face valence and intensity, respectively. Finally, we argue that some of the differences between studies are attributable to differences in the typicality of face stimuli. Specifically, extremely attractive faces are more likely to elicit responses in NAcc/caudate and mOFC. PMID:22287188

Milestone-specific, Observed data points for evaluating levels of performance (MODEL) assessment strategy for anesthesiology residency programs.

PubMed

Nagy, Christopher J; Fitzgerald, Brian M; Kraus, Gregory P

2014-01-01

Anesthesiology residency programs will be expected to have Milestones-based evaluation systems in place by July 2014 as part of the Next Accreditation System. The San Antonio Uniformed Services Health Education Consortium (SAUSHEC) anesthesiology residency program developed and implemented a Milestones-based feedback and evaluation system a year ahead of schedule. It has been named the Milestone-specific, Observed Data points for Evaluating Levels of performance (MODEL) assessment strategy. The "MODEL Menu" and the "MODEL Blueprint" are tools that other anesthesiology residency programs can use in developing their own Milestones-based feedback and evaluation systems prior to ACGME-required implementation. Data from our early experience with the streamlined MODEL blueprint assessment strategy showed substantially improved faculty compliance with reporting requirements. The MODEL assessment strategy provides programs with a workable assessment method for residents, and important Milestones data points to programs for ACGME reporting.

GEM-AQ, an On-line Global Multiscale Chemical Weather System: Model Description and Evaluation of Gas Phase Chemistry Processes

NASA Astrophysics Data System (ADS)

Neary, L.; Kaminski, J. W.; Struzewska, J.; Ainslie, B.; McConnell, J. C.

2007-12-01

Tropospheric chemistry and air quality processes were implemented on-line in the Global Environmental Multiscale model. The integrated model, GEM-AQ, has been developed as a platform to investigate chemical weather at scales from global to urban. On the global scale, the model was exercised for five years (2001-2005) to evaluate its ability to simulate seasonal variations and regional distributions of trace gases such as ozone, nitrogen dioxide and carbon monoxide. The model results are compared with observations from satellites, aircraft measurement campaigns and balloon sondes. The same model has also been evaluated on the regional (~15km resolution) and urban scale (~3km resolution). A simulation of the formation and transport of photooxidants during the European heat wave of 2006 was performed and compared with surface observations throughout central and eastern Europe. The complex topographic region of the Lower Fraser Valley in British Columbia was the focus of another model evaluation during the PACIFIC 2001 field campaign. Comparison of model results with observations during this period will be shown.

Seasat data utilization project

NASA Technical Reports Server (NTRS)

Born, G. H.; Held, D. N.; Lame, D. B.; Lipes, R. G.; Montgomery, D. R.; Rygh, P. J.; Scott, J. F.

1981-01-01

During the three months of orbital operations, the satellite returned data from the world's oceans. Dozens of tropical storms, hurricanes and typhoons were observed, and two planned major intensive surface truth experiments were conducted. The utility of the Seasat-A microwave sensors as oceanographic tools was determined. Sensor and geophysical evaluations are discussed, including surface observations, and evaluation summaries of an altimeter, a scatterometer, a scanning multichannel microwave radiometer, a synthetic aperture radar, and a visible and infrared radiometer.

A note on evaluating model tidal currents against observations

NASA Astrophysics Data System (ADS)

Cummins, Patrick F.; Thupaki, Pramod

2018-01-01

The root-mean-square magnitude of the vector difference between modeled and observed tidal ellipses is a comprehensive metric to evaluate the representation of tidal currents in ocean models. A practical expression for this difference is given in terms of the harmonic constants that are routinely used to specify current ellipses for a given tidal constituent. The resulting metric is sensitive to differences in all four current ellipse parameters, including phase.

Testing and Evaluating C3I Systems That Employ AI. Volume 4. Published Articles

DTIC Science & Technology

1991-01-31

development performance in an naming, design and actions The system ’ s & Sophisticated system organizational setting) evaluated in a classroom setting by...observing designed as an intelligent the system in use and administering training aid in r questionnaires . Observers videotape and tave classroom setting...notes to assess how both students and instructors use the system in an actual classroom setting. Questionnaires are administered to both students and

Inter-calibration and validation of observations from SAPHIR and ATMS instruments

NASA Astrophysics Data System (ADS)

Moradi, I.; Ferraro, R. R.

2015-12-01

We present the results of evaluating observations from microwave instruments aboard the Suomi National Polar-orbiting Partnership (NPP, ATMS instrument) and Megha-Tropiques (SAPHIR instrument) satellites. The study includes inter-comparison and inter-calibration of observations of similar channels from the two instruments, evaluation of the satellite data using high-quality radiosonde data from Atmospheric Radiation Measurement Program and GPS Radio Occultaion Observations from COSMIC mission, as well as geolocation error correction. The results of this study are valuable for generating climate data records from these instruments as well as for extending current climate data records from similar instruments such as AMSU-B and MHS to the ATMS and SAPHIR instruments. Reference: Moradi et al., Intercalibration and Validation of Observations From ATMS and SAPHIR Microwave Sounders. IEEE Transactions on Geoscience and Remote Sensing. 01/2015; DOI: 10.1109/TGRS.2015.2427165

LANDSAT-4 image data quality analysis

NASA Technical Reports Server (NTRS)

Anuta, P. E. (Principal Investigator)

1982-01-01

Work done on evaluating the geometric and radiometric quality of early LANDSAT-4 sensor data is described. Band to band and channel to channel registration evaluations were carried out using a line correlator. Visual blink comparisons were run on an image display to observe band to band registration over 512 x 512 pixel blocks. The results indicate a .5 pixel line misregistration between the 1.55 to 1.75, 2.08 to 2.35 micrometer bands and the first four bands. Also a four 30M line and column misregistration of the thermal IR band was observed. Radiometric evaluation included mean and variance analysis of individual detectors and principal components analysis. Results indicate that detector bias for all bands is very close or within tolerance. Bright spots were observed in the thermal IR band on an 18 line by 128 pixel grid. No explanation for this was pursued. The general overall quality of the TM was judged to be very high.

Audience-Oriented Writing and Peer Evaluation. SCO Cahier No. 19.

ERIC Educational Resources Information Center

Rijlaarsdam, G.

To demonstrate that peer evaluation is an appropriate means of improving written composition, particularly in terms of audience and goal orientation, the use of peer evaluation as a teaching method is discussed and then the connection between peer evaluation and audience awareness is drawn. Based on observation of Dutch 17-year-old students, the…

The Educational Predicament Confronting Taiwan's Gifted Programs: An Evaluation of Current Practices and Future Challenges

ERIC Educational Resources Information Center

Kao, Chen-yao

2012-01-01

This study examines the current problems affecting Taiwan's gifted education through a large-scale gifted program evaluation. Fifty-one gifted classes at 15 elementary schools and 62 gifted classes at 18 junior high schools were evaluated. The primary activities included in this biennial evaluation were document review, observation of…

Idea Evaluation: Error in Evaluating Highly Original Ideas

ERIC Educational Resources Information Center

Licuanan, Brian F.; Dailey, Lesley R.; Mumford, Michael D.

2007-01-01

Idea evaluation is a critical aspect of creative thought. However, a number of errors might occur in the evaluation of new ideas. One error commonly observed is the tendency to underestimate the originality of truly novel ideas. In the present study, an attempt was made to assess whether analysis of the process leading to the idea generation and…

Evaluation of Administrators: Issues and Practices. OSSC Bulletin Vol. 19, No. 10.

ERIC Educational Resources Information Center

Wills, Lewis A.

In this review of current practices it is observed that administrators are evaluated for two major purposes--(1) to provide a basis for school districts' decisions at the conclusion of the evaluation period, and (2) to provide feedback on performance to allow administrator improvement. A comparison is made of evaluation material from five school…

Examining the Levels of Job Satisfaction among Peer Evaluators

ERIC Educational Resources Information Center

Walker, Althea Rochelle

2013-01-01

This study focused on assessing the levels of job satisfaction among peer evaluators in a large, metropolitan public K-12 school district in Florida. Peer evaluators were defined as former classroom teachers with five or more years of teaching experience who observe and evaluate teachers with two or more years of teaching experience. Seventy-eight…

The Use of AMET and Automated Scripts for Model Evaluation

EPA Science Inventory

The Atmospheric Model Evaluation Tool (AMET) is a suite of software designed to facilitate the analysis and evaluation of meteorological and air quality models. AMET matches the model output for particular locations to the corresponding observed values from one or more networks ...

A Matrix for Processing Descriptive and Judgmental Data for Use with the Learning Area Sections of the "Evaluative Criteria," Sixth Edition.

ERIC Educational Resources Information Center

Pace, Vernon D.; Buser, Robert L.

1990-01-01

Presents a matrix that can be used by accreditation team members to gather, organize, analyze, and report descriptive and evaluative information about instructional support components, teacher observations/interviews, and curriculum evaluation. (DMM)

Development and Testing of a Direct Observation Code Training Protocol for Elementary Aged Students with Attention Deficit/Hyperactivity Disorder

ERIC Educational Resources Information Center

Steiner, Naomi J.; Sidhu, Tahnee; Rene, Kirsten; Tomasetti, Kathryn; Frenette, Elizabeth; Brennan, Robert T.

2013-01-01

Observational measures can add objective data to both research and clinical evaluations of children's behavior in the classroom. However, they pose challenges for training and attaining high levels of interrater reliability between observers. The Behavioral Observation of Students in Schools (BOSS) is a commonly used school-based observation…

Special Strategies Observation System-Revised: A Useful Tool for Educational Research and Evaluation

ERIC Educational Resources Information Center

Meehan, Merrill L.; Cowley, Kimberly S.; Finch, Nicole L.; Chadwick, Kristine L.; Ermolov, Lisa D.; Riffle, M. Joy S.

2004-01-01

A review of the critical literature provides a brief history of systematic observation of classroom behaviors, long valued as an important data collection method in educational research. Milestones in systematic observation of classrooms are traced back to 1914 and the development and use of the Special Strategies Observation System (SSOS) through…

Teacher Supervision and Evaluation: A Case Study of Administrators' and Teachers' Perceptions of Mini Observations

ERIC Educational Resources Information Center

Campbell, Thomas F.

2013-01-01

This case study will investigate teachers' and administrators' perceptions of the relationship between mini observations and teacher performance to understand what effect, if any, a system of mini observations has on teacher performance, and if mini observations influences a teacher's pedagogical practice differently than a…

Assimilating Remote Ammonia Observations with a Refined Aerosol Thermodynamics Adjoint"

EPA Science Inventory

Ammonia emissions parameters in North America can be refined in order to improve the evaluation of modeled concentrations against observations. Here, we seek to do so by developing and applying the GEOS-Chem adjoint nested over North America to conductassimilation of observations...

[Evaluation of Iris Morphology Viewed through Stromal Edematous Corneas by Infrared Camera].

PubMed

Kobayashi, Masaaki; Morishige, Naoyuki; Morita, Yukiko; Yamada, Naoyuki; Kobayashi, Motomi; Sonoda, Koh-Hei

2016-02-01

We reported that the application of infrared camera enables us to observe iris morphology in Peters' anomaly through edematous corneas. To observe the iris morphology in bullous keratopathy or failure grafts with an infrared camera. Eleven bullous keratopathy or failure grafts subjects (6 men and 5 women, mean age ± SD; 72.7 ± 13.0 years old) were enrolled in this study. The iris morphology was observed by applying visible light mode and near infrared light mode of infrared camera (MeibomPen). The detectability of pupil shapes, iris patterns and presence of iridectomy was evaluated. Infrared mode observation enabled us to detect the pupil shapes in 11 out of 11 cases, iris patterns in 3 out of 11 cases, and presence of iridetomy in 9 out of 11 cases although visible light mode observation could not detect any iris morphological changes. Applying infrared optics was valuable for observation of the iris morphology through stromal edematous corneas.

Do prehospital discharge pacemaker checks provide any additional clinical benefit?

PubMed

Wheelan, Kevin R; Legge, Darlene M; Sakowski, Brent C; Bruce, Susan S; Roberts, David C; Johnston, L Murphy; Moore, B Jane; Beveridge, Thomas P; Wells, Peter J; Vallabahn, Ravi; Donsky, Michael S; Franklin, Jay O

2005-08-01

We performed a retrospective analysis of 250 records of consecutive, newly implanted, pacemaker patients from a single center to determine the rate of postimplant complications and observations discovered before and during the prehospital discharge evaluation. No observations occurred in 246 of 250 patients (98.4%) (1-sided 95% confidence interval 96.4%). Of the 250 patients, 4 had observations that were discovered at the prehospital discharge check and required reprogramming to increase the sensitivity safety margin (3 atrial and 1 ventricular). We documented only 1 complication that was discovered before the predischarge evaluation through telemetry and resulted in an atrial lead revision.

"New Space Explosion" and Earth Observing System Capabilities

NASA Astrophysics Data System (ADS)

Stensaas, G. L.; Casey, K.; Snyder, G. I.; Christopherson, J.

2017-12-01

This presentation will describe recent developments in spaceborne remote sensing, including introduction to some of the increasing number of new firms entering the market, along with new systems and successes from established players, as well as industry consolidation reactions to these developments from communities of users. The information in this presentation will include inputs from the results of the Joint Agency Commercial Imagery Evaluation (JACIE) 2017 Civil Commercial Imagery Evaluation Workshop and the use of the US Geological Survey's Requirements Capabilities and Analysis for Earth Observation (RCA-EO) centralized Earth observing systems database and how system performance parameters are used with user science applications requirements.

Evaluating Fidelity: Predictive Validity for a Measure of Competent Adherence to the Oregon Model of Parent Management Training

PubMed Central

Forgatch, Marion S.; Patterson, Gerald R.; DeGarmo, David S.

2006-01-01

When efficacious interventions are implemented in real-world conditions, it is important to evaluate whether or not the programs are practiced as intended. This article presents the Fidelity of Implementation Rating System (FIMP), an observation-based measure assessing competent adherence to the Oregon model of Parent Management Training (PMTO). FIMP evaluates 5 dimensions of competent adherence to PMTO (i.e., knowledge, structure, teaching skill, clinical skill, and overall effectiveness) specified in the intervention model. Predictive validity for FIMP was evaluated with a subsample of stepfamilies participating in a preventive PMTO intervention. As hypothesized, high FIMP ratings predicted change in observed parenting practices from baseline to 12 months. The rigor and scope of adherence measures are discussed. PMID:16718302

Revisiting the relation between contingency awareness and attention: evaluative conditioning relies on a contingency focus.

PubMed

Kattner, Florian

2012-01-01

Although evaluative conditioning has occasionally been demonstrated in the absence of contingency awareness, many recent studies imply that its acquisition depends on the availability of attentional resources during conditioning. In previous experiments attention has typically been manipulated in a general way rather than looking at the particular focus of attention. The present study investigated the role of a focus on the CS-US contingency. Two separate distraction tasks were designed that either diverted attention from the stimuli or directed it to the stimuli while drawing attention away from the contingency between the stimuli. Both types of distraction were shown to eliminate evaluative conditioning. Significant evaluative conditioning was observed in a third group of participants who were required to attend the contingencies. A mediation analysis showed that the observed discrepancy in evaluative conditioning effects between groups was mediated by contingency awareness. The results imply that attention in terms of a stimulus focus is not sufficient for evaluative conditioning to occur. Rather, attention to the contingencies between stimuli appears to be crucial in evaluative conditioning, because it is supposed to foster the acquisition of contingency awareness.

Teacher Evaluation. Policy Brief.

ERIC Educational Resources Information Center

Glass, Gene V.

2004-01-01

Traditional forms of evaluating teachers (e.g., inspection of credentials, supervisor and peer observation and rating) for purposes of hiring, promotion, and salary increases have served the profession of teaching well for decades and should receive continued support in policy and practice. Newer forms of evaluation--primarily paper-and-pencil…

An Opinion of the Relationship Between Outpatient Department Organization and Evaluation of Clinical Competency

ERIC Educational Resources Information Center

Scherer, Paul R.

1978-01-01

Observations of a departmental and non-departmental outpatient service organization are compared regarding student attitude and evaluation, patient care, clinical exposure control, and faculty attitude and performance. Tables show the evaluation topics of each rotation in the departmental system. (LBH)

Professional Development through Formative Evaluation

ERIC Educational Resources Information Center

Nsibande, Rejoice; Garraway, James

2011-01-01

Formative evaluation and its associated methodology of reflection on practice are used extensively in academic staff development. In reflecting on formative evaluation processes in both more traditional and newer programmes conducted at a university of technology, a number of variables reported in the literature were observed to have influenced…

Nonverbal Communication across Eastern-Western Cultures: Facial Expressions during Interviews of Japanese Students

ERIC Educational Resources Information Center

Khoo, Keiko

2007-01-01

Background: Effective educational evaluations involve interviews, observations and nonverbal cue interpretations. Educators carry out these evaluative activities everyday as instructors, advisors or administrators, often relying on nothing but their intuition. These evaluations inform the future decisions. One must determine if students really…

Comprehensive Interdisciplinary Evaluation as Intervention for Young Children.

ERIC Educational Resources Information Center

Vig, Susan; Kaminer, Ruth

2003-01-01

This article explains how comprehensive interdisciplinary, clinically oriented evaluation can become an intervention by educating the parent about a child's development, providing a context for observation, identifying child and family strengths, and helping the parent to interact with the child. During the evaluation process, parents begin to…

Information Science and Responsive Evaluation

ERIC Educational Resources Information Center

Stake, Robert E.

2014-01-01

Responsive evaluation builds upon the methods of informal evaluation in disciplined ways: getting personally acquainted with the evaluand, observation of activities, interviewing people who are in different ways familiar with the evaluand, searching documents that reveal what happened in the past or somewhere else. It calls for sustained effort to…

Project Developmental Continuity: PDC Classroom Observation Manual.

ERIC Educational Resources Information Center

Meece, Judy; And Others

This classroom observation manual (Fall 1976) was developed for use in the evaluation of Project Developmental Continuity (PDC), a Head Start demonstration program aimed at providing educational and developmental continuity between children's Head Start and primary school experiences. The manual provides detailed instructions for the observer on…

78 FR 77428 - 2014 Annual Determination for Sea Turtle Observer Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-23

... Determination for Sea Turtle Observer Requirement AGENCY: National Marine Fisheries Service (NMFS), National... observing identified fisheries is to learn more about sea turtle interactions in a given fishery, evaluate existing measures to prevent or reduce prohibited sea turtle takes, and to determine whether additional...

77 FR 75999 - 2013 Annual Determination for Sea Turtle Observer Requirement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... Determination for Sea Turtle Observer Requirement AGENCY: National Marine Fisheries Service (NMFS), National... observing identified fisheries is to learn more about sea turtle interactions in a given fishery, evaluate existing measures to prevent or reduce prohibited sea turtle takes, and to determine whether additional...

Propensity Score Estimation With Boosted Regression for Evaluating Causal Effects in Observational Studies

ERIC Educational Resources Information Center

McCaffrey, Daniel F.; Ridgeway, Greg; Morral, Andrew R.

2004-01-01

Causal effect modeling with naturalistic rather than experimental data is challenging. In observational studies participants in different treatment conditions may also differ on pretreatment characteristics that influence outcomes. Propensity score methods can theoretically eliminate these confounds for all observed covariates, but accurate…

Observing Classroom Practice

ERIC Educational Resources Information Center

Danielson, Charlotte

2012-01-01

Classroom observation is a crucial aspect of any system of teacher evaluation. No matter how skilled a teacher is in other aspects of teaching--such as careful planning, working well with colleagues, and communicating with parents--if classroom practice is deficient, that individual cannot be considered a good teacher. Classroom observations can…

Two Decades of WRF/CMAQ simulations over the continental ...

EPA Pesticide Factsheets

Confidence in the application of models for forecasting and regulatory assessments is furthered by conducting four types of model evaluation: operational, dynamic, diagnostic, and probabilistic. Operational model evaluation alone does not reveal the confidence limits that can be associated with modeled air quality concentrations. This paper presents novel approaches for performing dynamic model evaluation and for evaluating the confidence limits of ozone exceedances using the WRF/CMAQ model simulations over the continental United States for the period from 1990 to 2010. The methodology presented here entails spectral decomposition of ozone time series using the KZ filter to assess the variations in the strengths of the synoptic (i.e., weather-induced variation) and baseline (i.e., long-term variation attributable to emissions, policy, and trends) forcings embedded in the modeled and observed concentrations. A method is presented where the future year observations are estimated based on the changes in the concentrations predicted by the model applied to the current year observations. The proposed method can provide confidence limits for ozone exceedances for a given emission reduction scenario. We present and discuss these new approaches to identify the strengths of the model in representing the changes in simulated O3 air quality over the 21-year period. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates

Prospective, randomized, blinded evaluation of donor semen quality provided by seven commercial sperm banks.

PubMed

Carrell, Douglas T; Cartmill, Deborah; Jones, Kirtly P; Hatasaka, Harry H; Peterson, C Matthew

2002-07-01

To evaluate variability in donor semen quality between seven commercial donor sperm banks, within sperm banks, and between intracervical insemination and intrauterine insemination. Prospective, randomized, blind evaluation of commercially available donor semen samples. An academic andrology laboratory. Seventy-five cryopreserved donor semen samples were evaluated. Samples were coded, then blindly evaluated for semen quality. Standard semen quality parameters, including concentration, motility parameters, World Health Organization criteria morphology, and strict criteria morphology. Significant differences were observed between donor semen banks for most semen quality parameters analyzed in intracervical insemination samples. In general, the greatest variability observed between banks was in percentage progressive sperm motility (range, 8.8 +/- 5.8 to 42.4 +/- 5.5) and normal sperm morphology (strict criteria; range, 10.1 +/- 3.3 to 26.6 +/- 4.7). Coefficients of variation within sperm banks were generally high. These data demonstrate the variability of donor semen quality provided by commercial sperm banks, both between banks and within a given bank. No relationship was observed between the size or type of sperm bank and the degree of variability. The data demonstrate the lack of uniformity in the criteria used to screen potential semen donors and emphasize the need for more stringent screening criteria and strict quality control in processing samples.

Validity and reliability of the Paprosky acetabular defect classification.

PubMed

Yu, Raymond; Hofstaetter, Jochen G; Sullivan, Thomas; Costi, Kerry; Howie, Donald W; Solomon, Lucian B

2013-07-01

The Paprosky acetabular defect classification is widely used but has not been appropriately validated. Reliability of the Paprosky system has not been evaluated in combination with standardized techniques of measurement and scoring. This study evaluated the reliability, teachability, and validity of the Paprosky acetabular defect classification. Preoperative radiographs from a random sample of 83 patients undergoing 85 acetabular revisions were classified by four observers, and their classifications were compared with quantitative intraoperative measurements. Teachability of the classification scheme was tested by dividing the four observers into two groups. The observers in Group 1 underwent three teaching sessions; those in Group 2 underwent one session and the influence of teaching on the accuracy of their classifications was ascertained. Radiographic evaluation showed statistically significant relationships with intraoperative measurements of anterior, medial, and superior acetabular defect sizes. Interobserver reliability improved substantially after teaching and did not improve without it. The weighted kappa coefficient went from 0.56 at Occasion 1 to 0.79 after three teaching sessions in Group 1 observers, and from 0.49 to 0.65 after one teaching session in Group 2 observers. The Paprosky system is valid and shows good reliability when combined with standardized definitions of radiographic landmarks and a structured analysis. Level II, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence.

A QUESTIONNAIRE TO ASSESS THE RELEVANCE AND CREDIBILITY OF OBSERVATIONAL STUDIES TO INFORM HEALTH CARE DECISION MAKING: AN ISPOR-AMCP-NPC GOOD PRACTICE TASK FORCE REPORT

PubMed Central

Berger, Marc L; Martin, Bradley C; Husereau, Don; Worley, Karen; Allen, Dan; Yang, Winnie; Mullins, C. Daniel; Kahler, Kristijan; Quon, Nicole C.; Devine, Scott; Graham, John; Cannon, Eric; Crown, William

2014-01-01

Evidence-based healthcare decisions are best informed by comparisons of all relevant interventions used to treat conditions in specific patient populations. Observational studies are being performed to help fill evidence gaps. However, widespread adoption of evidence from observational studies has been limited due to a variety of factors, including the lack of consensus regarding accepted principles for their evaluation and interpretation. Two Task Forces were formed to develop questionnaires to assist decision makers in evaluating observational studies, with one Task Force addressing retrospective research and the other prospective research. The intent was to promote a structured approach to reduce the potential for subjective interpretation of evidence and drive consistency in decision-making. Separately developed questionnaires were combined into a single questionnaire consisting of 33 items. These were divided into two domains: relevance and credibility. Relevance addresses the extent to which findings, if accurate, apply to the setting of interest to the decision maker. Credibility addresses the extent to which the study findings accurately answer the study question. The questionnaire provides a guide for assessing the degree of confidence that should be placed from observational studies and promotes awareness of the subtleties involved in evaluating those. PMID:24636373

Evaluation of Global Observations-Based Evapotranspiration Datasets and IPCC AR4 Simulations

NASA Technical Reports Server (NTRS)

Mueller, B.; Seneviratne, S. I.; Jimenez, C.; Corti, T.; Hirschi, M.; Balsamo, G.; Ciais, P.; Dirmeyer, P.; Fisher, J. B.; Guo, Z.;

Evaluation of hand hygiene adherence in a tertiary hospital.

PubMed

Novoa, Ana M; Pi-Sunyer, Teresa; Sala, Maria; Molins, Eduard; Castells, Xavier

2007-12-01

Although hand hygiene is the most important measure in the prevention of nosocomial infection, adherence to recommendations among health care workers (HCW) is low. Evaluation of compliance with hand hygiene was carried out in a Spanish teaching hospital. In 2005, adherence to hand hygiene was evaluated hospital wide through direct observation, collecting data on hand hygiene carried out whenever indicated (opportunity for hand hygiene). Compliance was defined as handwashing/disinfection in an opportunity for hand hygiene according to hospital protocols. The results were analyzed using mixed effects models, with the HCW observed as the random effect. A total of 1254 opportunities for hand hygiene were observed in 247 HCWs. Mean compliance was 20%. Although few differences were observed among types of HCW, compliance varied according to hospital area (69% in the intensive care unit [ICU]) and timing with respect to patient contact (compliance after contact was twice that before contact). Multivariate analyses revealed a protective odds ratio (OR) for nonadherence in ICUs (OR, 0.04; 95% confidence interval (95% CI): 0.01-0.10) and after patient contact (OR, 0.25; 95% CI: 0.17-0.38). Low adherence observed suggests that new interventions should focus in modification of HCWs' habits and attitudes, working at several levels: individual and institutional.

Evaluating the Population Impact on Racial/Ethnic Disparities in HIV in Adulthood of Intervening on Specific Targets: A Conceptual and Methodological Framework.

PubMed

Howe, Chanelle J; Dulin-Keita, Akilah; Cole, Stephen R; Hogan, Joseph W; Lau, Bryan; Moore, Richard D; Mathews, W Christopher; Crane, Heidi M; Drozd, Daniel R; Geng, Elvin; Boswell, Stephen L; Napravnik, Sonia; Eron, Joseph J; Mugavero, Michael J

2018-02-01

Reducing racial/ethnic disparities in human immunodeficiency virus (HIV) disease is a high priority. Reductions in HIV racial/ethnic disparities can potentially be achieved by intervening on important intermediate factors. The potential population impact of intervening on intermediates can be evaluated using observational data when certain conditions are met. However, using standard stratification-based approaches commonly employed in the observational HIV literature to estimate the potential population impact in this setting may yield results that do not accurately estimate quantities of interest. Here we describe a useful conceptual and methodological framework for using observational data to appropriately evaluate the impact on HIV racial/ethnic disparities of interventions. This framework reframes relevant scientific questions in terms of a controlled direct effect and estimates a corresponding proportion eliminated. We review methods and conditions sufficient for accurate estimation within the proposed framework. We use the framework to analyze data on 2,329 participants in the CFAR [Centers for AIDS Research] Network of Integrated Clinical Systems (2008-2014) to evaluate the potential impact of universal prescription of and ≥95% adherence to antiretroviral therapy on racial disparities in HIV virological suppression. We encourage the use of the described framework to appropriately evaluate the potential impact of targeted interventions in addressing HIV racial/ethnic disparities using observational data. © The Author(s) 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Characterization of ventricular depolarization and repolarization changes in a porcine model of myocardial infarction.

PubMed

Romero, Daniel; Ringborn, Michael; Demidova, Marina; Koul, Sasha; Laguna, Pablo; Platonov, Pyotr G; Pueyo, Esther

2012-12-01

In this study, several electrocardiogram (ECG)-derived indices corresponding to both ventricular depolarization and repolarization were evaluated during acute myocardial ischemia in an experimental model of myocardial infarction produced by 40 min coronary balloon inflation in 13 pigs. Significant changes were rapidly observed from minute 4 after the start of coronary occlusion, achieving their maximum values between 11 and 22 min for depolarization and between 9 and 12 min for repolarization indices, respectively. Subsequently, these maximum changes started to decrease during the latter part of the occlusion. Depolarization changes associated with the second half of the QRS complex showed a significant but inverse correlation with the myocardium at risk (MaR) estimated by scintigraphic images. The correlation between MaR and changes of the downward slope of the QRS complex, [Formula: see text], evaluated at the two more relevant peaks observed during the occlusion, was r = -0.75, p < 0.01 and r = -0.79, p < 0.01 for the positive and negative deflections observed in [Formula: see text], temporal evolution, respectively. Repolarization changes, analyzed by evaluation of ST segment elevation at the main observed positive peak, also showed negative, however non-significant correlation with MaR: r = -0.34, p = 0.28. Our results suggest that changes evaluated in the latter part of the depolarization, such as those described by [Formula: see text], which are influenced by R-wave amplitude, QRS width and ST level variations simultaneously, correlate better with the amount of ischemia than other indices evaluated in the earlier part of depolarization or during the ST segment.

The MERRA-2 Aerosol Reanalysis, 1980 - onward, Part I: System Description and Data Assimilation Evaluation.

PubMed

Randles, C A; Da Silva, A M; Buchard, V; Colarco, P R; Darmenov, A; Govindaraju, R; Smirnov, A; Holben, B; Ferrare, R; Hair, J; Shinozuka, Y; Flynn, C J

2017-09-01

The Modern-Era Retrospective Analysis for Research and Applications, Version 2 (MERRA-2) updates NASA's previous satellite era (1980 - onward) reanalysis system to include additional observations and improvements to the Goddard Earth Observing System, Version 5 (GEOS-5) Earth system model. As a major step towards a full Integrated Earth Systems Analysis (IESA), in addition to meteorological observations, MERRA-2 now includes assimilation of aerosol optical depth (AOD) from various ground- and space-based remote sensing platforms. Here, in the first of a pair of studies, we document the MERRA-2 aerosol assimilation, including a description of the prognostic model (GEOS-5 coupled to the GOCART aerosol module), aerosol emissions, and the quality control of ingested observations. We provide initial validation and evaluation of the analyzed AOD fields using independent observations from ground, aircraft, and shipborne instruments. We demonstrate the positive impact of the AOD assimilation on simulated aerosols by comparing MERRA-2 aerosol fields to an identical control simulation that does not include AOD assimilation. Having shown the AOD evaluation, we take a first look at aerosol-climate interactions by examining the shortwave, clear-sky aerosol direct radiative effect. In our companion paper, we evaluate and validate available MERRA-2 aerosol properties not directly impacted by the AOD assimilation (e.g. aerosol vertical distribution and absorption). Importantly, while highlighting the skill of the MERRA-2 aerosol assimilation products, both studies point out caveats that must be considered when using this new reanalysis product for future studies of aerosols and their interactions with weather and climate.

Alpha1 LASSO data bundles Lamont, OK

DOE Data Explorer

Gustafson, William Jr; Vogelmann, Andrew; Endo, Satoshi; Toto, Tami; Xiao, Heng; Li, Zhijin; Cheng, Xiaoping; Krishna, Bhargavi (ORCID:000000018828528X)

2016-08-03

A data bundle is a unified package consisting of LASSO LES input and output, observations, evaluation diagnostics, and model skill scores. LES input includes model configuration information and forcing data. LES output includes profile statistics and full domain fields of cloud and environmental variables. Model evaluation data consists of LES output and ARM observations co-registered on the same grid and sampling frequency. Model performance is quantified by skill scores and diagnostics in terms of cloud and environmental variables.

Assessing Changes in High School Students' Conceptual Understanding through Concept Maps before and after the Computer-Based Predict-Observe-Explain (CB-POE) Tasks on Acid-Base Chemistry at the Secondary Level

ERIC Educational Resources Information Center

Yaman, Fatma; Ayas, Alipasa

2015-01-01

Although concept maps have been used as alternative assessment methods in education, there has been an ongoing debate on how to evaluate students' concept maps. This study discusses how to evaluate students' concept maps as an assessment tool before and after 15 computer-based Predict-Observe-Explain (CB-POE) tasks related to acid-base chemistry.…

Power-law behaviour evaluation from foreign exchange market data using a wavelet transform method

NASA Astrophysics Data System (ADS)

Wei, H. L.; Billings, S. A.

2009-09-01

Numerous studies in the literature have shown that the dynamics of many time series including observations in foreign exchange markets exhibit scaling behaviours. A simple new statistical approach, derived from the concept of the continuous wavelet transform correlation function (WTCF), is proposed for the evaluation of power-law properties from observed data. The new method reveals that foreign exchange rates obey power-laws and thus belong to the class of self-similarity processes.

Evaluation of water matrix effects, experimental parameters, and the degradation pathway during the TiO2 photocatalytical treatment of the antibiotic dicloxacillin.

PubMed

Villegas-Guzman, Paola; Silva-Agredo, Javier; González-Gómez, Duván; Giraldo-Aguirre, Ana L; Flórez-Acosta, Oscar; Torres-Palma, Ricardo A

2015-01-01

The photocalytic degradation of dicloxacillin (DXC) using TiO2 was studied in synthetic and natural waters. The degradation route and the effect of different experimental variables such as pH, applied power, and the initial concentrations of DXC and the catalyst were investigated. The best performances were achieved at a natural pH 5.8 and using 2.0 g L(-1) of TiO2 with 150 W of applied power. The photodegradation process followed Langmuir-Hinshelwood kinetics. The water matrix effect was evaluated in terms of degradation efficiency in the presence of organic compounds (oxalic acid, glucose), Fe(2+) ion and natural water. An increase in degradation was observed when ferrous ion was part of the solution, but the process was inhibited with all evaluated organic compounds. Similarly, inhibition was observed when natural water was used instead of distilled water. The extent of degradation of the process was evaluated following the evolution of chemical oxygen demand (COD), antimicrobial activity (AA), total organic carbon (TOC) and biochemical oxygen demand (BOD5). Total removal of DXC was achieved after 120 min of treatment and 95% mineralization was observed after 480 min of treatment. Additionally, the total removal of antimicrobial activity and a high level of biodegradability were observed after the photocalytical system had been operating for 240 min.

Using cloud-based mobile technology for assessment of competencies among medical students.

PubMed

Ferenchick, Gary S; Solomon, David

2013-01-01

Valid, direct observation of medical student competency in clinical settings remains challenging and limits the opportunity to promote performance-based student advancement. The rationale for direct observation is to ascertain that students have acquired the core clinical competencies needed to care for patients. Too often student observation results in highly variable evaluations which are skewed by factors other than the student's actual performance. Among the barriers to effective direct observation and assessment include the lack of effective tools and strategies for assuring that transparent standards are used for judging clinical competency in authentic clinical settings. We developed a web-based content management system under the name, Just in Time Medicine (JIT), to address many of these issues. The goals of JIT were fourfold: First, to create a self-service interface allowing faculty with average computing skills to author customizable content and criterion-based assessment tools displayable on internet enabled devices, including mobile devices; second, to create an assessment and feedback tool capable of capturing learner progress related to hundreds of clinical skills; third, to enable easy access and utilization of these tools by faculty for learner assessment in authentic clinical settings as a means of just in time faculty development; fourth, to create a permanent record of the trainees' observed skills useful for both learner and program evaluation. From July 2010 through October 2012, we implemented a JIT enabled clinical evaluation exercise (CEX) among 367 third year internal medicine students. Observers (attending physicians and residents) performed CEX assessments using JIT to guide and document their observations, record their time observing and providing feedback to the students, and their overall satisfaction. Inter-rater reliability and validity were assessed with 17 observers who viewed six videotaped student-patient encounters and by measuring the correlation between student CEX scores and their scores on subsequent standardized-patient OSCE exams. A total of 3567 CEXs were completed by 516 observers. The average number of evaluations per student was 9.7 (±1.8 SD) and the average number of CEXs completed per observer was 6.9 (±15.8 SD). Observers spent less than 10 min on 43-50% of the CEXs and 68.6% on feedback sessions. A majority of observers (92%) reported satisfaction with the CEX. Inter-rater reliability was measured at 0.69 among all observers viewing the videotapes and these ratings adequately discriminated competent from non-competent performance. The measured CEX grades correlated with subsequent student performance on an end-of-year OSCE. We conclude that the use of JIT is feasible in capturing discrete clinical performance data with a high degree of user satisfaction. Our embedded checklists had adequate inter-rater reliability and concurrent and predictive validity.

A Ground-Based Doppler Radar and Micropulse Lidar Forward Simulator for GCM Evaluation of Arctic Mixed-Phase Clouds: Moving Forward Towards an Apples-to-apples Comparison of Hydrometeor Phase

NASA Astrophysics Data System (ADS)

Lamer, K.; Fridlind, A. M.; Ackerman, A. S.; Kollias, P.; Clothiaux, E. E.

2017-12-01

An important aspect of evaluating Artic cloud representation in a general circulation model (GCM) consists of using observational benchmarks which are as equivalent as possible to model output in order to avoid methodological bias and focus on correctly diagnosing model dynamical and microphysical misrepresentations. However, current cloud observing systems are known to suffer from biases such as limited sensitivity, and stronger response to large or small hydrometeors. Fortunately, while these observational biases cannot be corrected, they are often well understood and can be reproduced in forward simulations. Here a ground-based millimeter wavelength Doppler radar and micropulse lidar forward simulator able to interface with output from the Goddard Institute for Space Studies (GISS) ModelE GCM is presented. ModelE stratiform hydrometeor fraction, mixing ratio, mass-weighted fall speed and effective radius are forward simulated to vertically-resolved profiles of radar reflectivity, Doppler velocity and spectrum width as well as lidar backscatter and depolarization ratio. These forward simulated fields are then compared to Atmospheric Radiation Measurement (ARM) North Slope of Alaska (NSA) ground-based observations to assess cloud vertical structure (CVS). Model evalution of Arctic mixed-phase cloud would also benefit from hydrometeor phase evaluation. While phase retrieval from synergetic observations often generates large uncertainties, the same retrieval algorithm can be applied to observed and forward-simulated radar-lidar fields, thereby producing retrieved hydrometeor properties with potentially the same uncertainties. Comparing hydrometeor properties retrieved in exactly the same way aims to produce the best apples-to-apples comparisons between GCM ouputs and observations. The use of a comprenhensive ground-based forward simulator coupled with a hydrometeor classification retrieval algorithm provides a new perspective for GCM evaluation of Arctic mixed-phase clouds from the ground where low-level supercooled liquid layer are more easily observed and where additional environmental properties such as cloud condensation nuclei are quantified. This should help assist in choosing between several possible diagnostic ice nucleation schemes for ModelE stratiform cloud.

Can Principals Promote Teacher Development as Evaluators? A Case Study of Principals' Views and Experiences.

PubMed

Kraft, Matthew A; Gilmour, Allison

2016-12-01

New teacher evaluation systems have expanded the role of principals as instructional leaders, but little is known about principals' ability to promote teacher development through the evaluation process. We conducted a case study of principals' perspectives on evaluation and their experiences implementing observation and feedback cycles to better understand whether principals feel as though they are able to promote teacher development as evaluators. We conducted interviews with a stratified random sample of 24 principals in an urban district that recently implemented major reforms to its teacher evaluation system. We analyzed these interviews by drafting thematic summaries, coding interview transcripts, creating data-analytic matrices, and writing analytic memos. We found that the evaluation reforms provided a common framework and language that helped facilitate principals' feedback conversations with teachers. However, we also found that tasking principals with primary responsibility for conducting evaluations resulted in a variety of unintended consequences which undercut the quality of evaluation feedback they provided. We analyze five broad solutions to these challenges: strategically targeting evaluations, reducing operational responsibilities, providing principal training, hiring instructional coaches, and developing peer evaluation systems. The quality of feedback teachers receive through the evaluation process depends critically on the time and training evaluators have to provide individualized and actionable feedback. Districts that task principals with primary responsibility for conducting observation and feedback cycles must attend to the many implementation challenges associated with this approach in order for next-generation evaluation systems to successfully promote teacher development.

Clinical Knowledge from Observational Studies: Everything You Wanted to Know but Were Afraid to Ask.

PubMed

Gershon, Andrea S; Jafarzadeh, S Reza; Wilson, Kevin C; Walkey, Allan J

2018-05-07

Well-done randomized trials provide accurate estimates of treatment effect by producing groups that are similar on all measures except for the intervention of interest. However, inferences of efficacy in tightly-controlled experimental settings may not translate into similar effectiveness in real-world settings. Observational studies generally enable inferences over a wider range of patient characteristics and evaluation of a broader range of outcomes over a longer period than randomized trials. However, clinicians are often reluctant to incorporate the findings of observational studies into clinical practice. Reason for uncertainty regarding observational studies include a lack of familiarity with observational research methods, occasional disagreements between results of observational studies and randomized trials, the perceived risk of spurious results from systematic bias, and prior teaching that randomized trials are the most reliable source of medical evidence. We propose that a better understanding of observational research will enhance clinicians' ability to distinguish reliable observational studies from those that are subjected to biases and, therefore, provide more confidence to apply observational research results into clinical practice when appropriate. Herein, we explain why observational studies may be perceived as less conclusive than randomized trials, address situations in which observational research and randomized trials produced different findings, and provide information on observational study design so that quality can be evaluated. We conclude that observational research is a valuable source of medical evidence and that clinical action is strongest when supported by both high quality observational studies and randomized trials.

Clinical performance of a glass ionomer restorative system: a 6-year evaluation.

PubMed

Gurgan, Sevil; Kutuk, Zeynep Bilge; Ergin, Esra; Oztas, Sema Seval; Cakir, Filiz Yalcin

2017-09-01

The aim of this study is to evaluate the long-term clinical performance of a glass ionomer (GI) restorative system in the restoration of posterior teeth compared with a micro-filled hybrid posterior composite. A total of 140 (80 Cl1 and 60 Cl2) lesions in 59 patients were restored with a GI system (Equia) or a micro hybrid composite (Gradia Direct). Restorations were evaluated at baseline and yearly during 6 years according to the modified-USPHS criteria. Negative replicas at each recall were observed under SEM to evaluate surface characteristics. Data were analyzed with Cohcran's Q and McNemar's tests (p < 0.05). One hundred fifteen (70 Cl1 and 45 Cl2) restorations were evaluated in 47 patients with a recall rate of 79.6% at 6 years. Significant differences were found in marginal adaptation and marginal discoloration for both restorative materials for Cl1 and Cl2 restorations (p < 0.05). However, none of the materials were superior to the other (p > 0.05). A significant decrease in color match was observed in Equia restorations (p < 0.05). Only one Cl2 Equia restoration was missing at 3 years and another one at 4 years. No failures were observed at 5 and 6 years. Both materials exhibited clinically successful performance after 6 years. SEM evaluations were in accordance with the clinical findings. Both materials showed a good clinical performance for the restoration of posterior teeth during the 6-year evaluation. The clinical effectiveness of Equia and Gradia Direct Posterior was acceptable in Cl1 and Cl2 cavities subsequent to 6-year evaluation.

Pre-training evaluation and feedback improved skills retention of basic life support in medical students.

PubMed

Li, Qi; Zhou, Rong-hua; Liu, Jin; Lin, Jing; Ma, Er-Li; Liang, Peng; Shi, Ting-wei; Fang, Li-qun; Xiao, Hong

2013-09-01

Pre-training evaluation and feedback have been shown to improve medical students' skills acquisition of basic life support (BLS) immediately following training. The impact of such training on BLS skills retention is unknown. This study was conducted to investigate effects of pre-training evaluation and feedback on BLS skills retention in medical students. Three hundred and thirty 3rd year medical students were randomized to two groups, the control group (C group) and pre-training evaluation and feedback group (EF group). Each group was subdivided into four subgroups according to the time of retention-test (at 1-, 3-, 6-, 12-month following the initial training). After a 45-min BLS lecture, BLS skills were assessed (pre-training evaluation) in both groups before training. Following this, the C group received 45 min training. 15 min of group feedback corresponding to students' performance in pre-training evaluation was given only in the EF group that was followed by 30 min of BLS training. BLS skills were assessed immediately after training (post-test) and at follow up (retention-test). No skills difference was observed between the two groups in pre-training evaluation. Better skills acquisition was observed in the EF group (85.3 ± 7.3 vs. 68.1 ± 12.2 in C group) at post-test (p<0.001). In all retention-test, better skills retention was observed in each EF subgroup, compared with its paired C subgroup. Pre-training evaluation and feedback improved skills retention in the EF group for 12 months after the initial training, compared with the control group. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Clinical Performance Evaluations of Third-Year Medical Students and Association With Student and Evaluator Gender.

PubMed

Riese, Alison; Rappaport, Leah; Alverson, Brian; Park, Sangshin; Rockney, Randal M

2017-06-01

Clinical performance evaluations are major components of medical school clerkship grades. But are they sufficiently objective? This study aimed to determine whether student and evaluator gender is associated with assessment of overall clinical performance. This was a retrospective analysis of 4,272 core clerkship clinical performance evaluations by 829 evaluators of 155 third-year students, within the Alpert Medical School grading database for the 2013-2014 academic year. Overall clinical performance, assessed on a three-point scale (meets expectations, above expectations, exceptional), was extracted from each evaluation, as well as evaluator gender, age, training level, department, student gender and age, and length of observation time. Hierarchical ordinal regression modeling was conducted to account for clustering of evaluations. Female students were more likely to receive a better grade than males (adjusted odds ratio [AOR] 1.30, 95% confidence interval [CI] 1.13-1.50), and female evaluators awarded lower grades than males (AOR 0.72, 95% CI 0.55-0.93), adjusting for department, observation time, and student and evaluator age. The interaction between student and evaluator gender was significant (P = .03), with female evaluators assigning higher grades to female students, while male evaluators' grading did not differ by student gender. Students who spent a short time with evaluators were also more likely to get a lower grade. A one-year examination of all third-year clerkship clinical performance evaluations at a single institution revealed that male and female evaluators rated male and female students differently, even when accounting for other measured variables.

Performance evaluation of contrast-detail in full field digital mammography systems using ideal (Hotelling) observer vs. conventional automated analysis of CDMAM images for quality control of contrast-detail characteristics.

PubMed

Delakis, Ioannis; Wise, Robert; Morris, Lauren; Kulama, Eugenia

2015-11-01

The purpose of this work was to evaluate the contrast-detail performance of full field digital mammography (FFDM) systems using ideal (Hotelling) observer Signal-to-Noise Ratio (SNR) methodology and ascertain whether it can be considered an alternative to the conventional, automated analysis of CDMAM phantom images. Five FFDM units currently used in the national breast screening programme were evaluated, which differed with respect to age, detector, Automatic Exposure Control (AEC) and target/filter combination. Contrast-detail performance was analysed using CDMAM and ideal observer SNR methodology. The ideal observer SNR was calculated for input signal originating from gold discs of varying thicknesses and diameters, and then used to estimate the threshold gold thickness for each diameter as per CDMAM analysis. The variability of both methods and the dependence of CDMAM analysis on phantom manufacturing discrepancies also investigated. Results from both CDMAM and ideal observer methodologies were informative differentiators of FFDM systems' contrast-detail performance, displaying comparable patterns with respect to the FFDM systems' type and age. CDMAM results suggested higher threshold gold thickness values compared with the ideal observer methodology, especially for small-diameter details, which can be attributed to the behaviour of the CDMAM phantom used in this study. In addition, ideal observer methodology results showed lower variability than CDMAM results. The Ideal observer SNR methodology can provide a useful metric of the FFDM systems' contrast detail characteristics and could be considered a surrogate for conventional, automated analysis of CDMAM images. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Diagnostic value of DIAGNOdent in detecting caries under composite restorations of primary molars

PubMed Central

Sichani, Ava Vali; Javadinejad, Shahrzad; Ghafari, Roshanak

2016-01-01

Background: Direct observation cannot detect caries under restorations; therefore, the aim of this study was to compare the accuracy of radiographs and DIAGNOdent in detecting caries under restorations in primary teeth using histologic evaluation. Materials and Methods: A total of 74 previously extracted primary molars (37 with occlusal caries and 37 without caries) were used. Class 1 cavity preparations were made on each tooth by a single clinician and then the preparations were filled with composite resin. The accuracy of radiographs and DIAGNOdent in detecting caries was compared using histologic evaluation. The data were analyzed by SPSS version 21 using Chi-square, Mc Namara statistical tests and receiver operating characteristic curve. The significance was set at 0.05. Results: The sensitivity and specificity for DIAGNOdent were 70.97 and 83.72, respectively. Few false negative results were observed, and the positive predictive value was high (+PV = 75.9) and the area under curve was more than 0.70 therefore making DIAGNOdenta great method for detecting caries (P = 0.0001). Two observers evaluated the radiographs and both observers had low sensitivity ( first observer: 48.39) (second observer: 51.61) and high specificity (both observers: 79.07). The +PV was lower than DIAGNOdent and the area under curve for both observers was less than 0.70. However, the difference between the two methods was not significant. Conclusion: DIAGNOdent showed a greater accuracy in detecting secondary caries under primary molar restorations, compared to radiographs. Although DIAGNOdent is an effective method for detecting caries under composite restorations, it is better to be used as an adjunctive method alongside other detecting procedures. PMID:27605990

Evaluating and improving cloud phase in the Community Atmosphere Model version 5 using spaceborne lidar observations

NASA Astrophysics Data System (ADS)

Kay, Jennifer E.; Bourdages, Line; Miller, Nathaniel B.; Morrison, Ariel; Yettella, Vineel; Chepfer, Helene; Eaton, Brian

2016-04-01

Spaceborne lidar observations from the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite are used to evaluate cloud amount and cloud phase in the Community Atmosphere Model version 5 (CAM5), the atmospheric component of a widely used state-of-the-art global coupled climate model (Community Earth System Model). By embedding a lidar simulator within CAM5, the idiosyncrasies of spaceborne lidar cloud detection and phase assignment are replicated. As a result, this study makes scale-aware and definition-aware comparisons between model-simulated and observed cloud amount and cloud phase. In the global mean, CAM5 has insufficient liquid cloud and excessive ice cloud when compared to CALIPSO observations. Over the ice-covered Arctic Ocean, CAM5 has insufficient liquid cloud in all seasons. Having important implications for projections of future sea level rise, a liquid cloud deficit contributes to a cold bias of 2-3°C for summer daily maximum near-surface air temperatures at Summit, Greenland. Over the midlatitude storm tracks, CAM5 has excessive ice cloud and insufficient liquid cloud. Storm track cloud phase biases in CAM5 maximize over the Southern Ocean, which also has larger-than-observed seasonal variations in cloud phase. Physical parameter modifications reduce the Southern Ocean cloud phase and shortwave radiation biases in CAM5 and illustrate the power of the CALIPSO observations as an observational constraint. The results also highlight the importance of using a regime-based, as opposed to a geographic-based, model evaluation approach. More generally, the results demonstrate the importance and value of simulator-enabled comparisons of cloud phase in models used for future climate projection.

Three-column classification and Schatzker classification: a three- and two-dimensional computed tomography characterisation and analysis of tibial plateau fractures.

PubMed

Patange Subba Rao, Sheethal Prasad; Lewis, James; Haddad, Ziad; Paringe, Vishal; Mohanty, Khitish

2014-10-01

The aim of the study was to evaluate inter-observer reliability and intra-observer reproducibility between the three-column classification and Schatzker classification systems using 2D and 3D CT models. Fifty-two consecutive patients with tibial plateau fractures were evaluated by five orthopaedic surgeons. All patients were classified into Schatzker and three-column classification systems using x-rays and 2D and 3D CT images. The inter-observer reliability was evaluated in the first round and the intra-observer reliability was determined during the second round 2 weeks later. The average intra-observer reproducibility for the three-column classification was from substantial to excellent in all sub classifications, as compared with Schatzker classification. The inter-observer kappa values increased from substantial to excellent in three-column classification and to moderate in Schatzker classification The average values for three-column classification for all the categories are as follows: (I-III) k2D = 0.718, 95% CI 0.554-0.864, p < 0.0001 and average 3D = 0.874, 95% CI 0.754-0.890, p < 0.0001. For Schatzker classification system, the average values for all six categories are as follows: (I-VI) k2D = 0.536, 95% CI 0.365-0.685, p < 0.0001 and average k3D = 0.552 95% CI 0.405-0.700, p < 0.0001. The values are statistically significant. Statistically significant inter-observer values in both rounds were noted with the three-column classification, making it statistically an excellent agreement. The intra-observer reproducibility for the three-column classification improved as compared with the Schatzker classification. The three-column classification seems to be an effective way to characterise and classify fractures of tibial plateau.

The PIE Institute Project: Final Evaluation Report

ERIC Educational Resources Information Center

St. John, Mark; Carroll, Becky; Helms, Jen; Smith, Anita

2008-01-01

The Playful Invention and Exploration (PIE) Institute project was funded in 2005 by the National Science Foundation (NSF). For the past three years, Inverness Research has served as the external evaluator for the PIE project. The authors' evaluation efforts have included extensive observation and documentation of PIE project activities; ongoing…

Evaluation of the Alberta School for the Deaf.

ERIC Educational Resources Information Center

Clarke, S. C. T.; Nyberg, V. R.

The report summarized a formative evaluation of the Alberta (Canada) School for the Deaf (ASD). Data were collected via observations by 12 consultants; interviews; and questionnaires completed by parents, teachers, students, and administrators. The evaluation was designed to focus on such aspects as instruction (including curriculum) and total…

Getting Classroom Observations Right

ERIC Educational Resources Information Center

Whitehurst, Grover; Chingos, Matthew M.; Lindquist, Katharine

2015-01-01

This article contributes to the body of knowledge on teacher evaluation systems by examining the actual design and performance of new teacher-evaluation systems in four school districts that are at the forefront of the effort to evaluate teachers meaningfully. The authors find first that the ratings assigned teachers by the districts'…

Teacher Evaluations: Use or Misuse?

ERIC Educational Resources Information Center

Warring, Douglas F.

2015-01-01

This manuscript examines value added measures used in teacher evaluations. The evaluations are often based on limited observations and use student growth as measured by standardized tests. These measures typically do not use multiple measures or consider other factors in the teaching and learning process. This manuscript identifies some of the…