Preschool Children's Fundamental Motor Skills: A Review of Significant Determinants

ERIC Educational Resources Information Center

Iivonen, S.; Sääkslahti, A. K.

2014-01-01

Fundamental motor skills (FMS) affect children's physical, social, and cognitive development. To plan successful interventions when promoting the development of children's FMS, the underlying positive determinants for the acquisition of FMS competence during preschool years need to be identified. The purpose of this systematic review was…

Effectiveness of a fundamental motor skill intervention for 4-year-old children with autism spectrum disorder: A pilot study.

PubMed

Bremer, Emily; Balogh, Robert; Lloyd, Meghann

2015-11-01

A wait-list control experimental design was employed to investigate the effectiveness of a fundamental motor skill intervention at improving the motor skills, adaptive behavior, and social skills of 4-year-old children with autism spectrum disorder (experimental n = 5, control n = 4); the impact of intervention intensity was also explored. The experimental group significantly improved their object manipulation and overall motor scores from pre- to post-intervention. The wait-list control design revealed no group-by-time interactions; however, with the groups combined time was a significant factor for all motor variables. There were no significant changes in adaptive behavior and social skills. These preliminary findings suggest that a fundamental motor skill intervention may benefit young children with autism spectrum disorder. Future research with larger samples is warranted. © The Author(s) 2014.

Fundamental aspects of steady-state conversion of heat to work at the nanoscale

NASA Astrophysics Data System (ADS)

Benenti, Giuliano; Casati, Giulio; Saito, Keiji; Whitney, Robert S.

2017-06-01

In recent years, the study of heat to work conversion has been re-invigorated by nanotechnology. Steady-state devices do this conversion without any macroscopic moving parts, through steady-state flows of microscopic particles such as electrons, photons, phonons, etc. This review aims to introduce some of the theories used to describe these steady-state flows in a variety of mesoscopic or nanoscale systems. These theories are introduced in the context of idealized machines which convert heat into electrical power (heat-engines) or convert electrical power into a heat flow (refrigerators). In this sense, the machines could be categorized as thermoelectrics, although this should be understood to include photovoltaics when the heat source is the sun. As quantum mechanics is important for most such machines, they fall into the field of quantum thermodynamics. In many cases, the machines we consider have few degrees of freedom, however the reservoirs of heat and work that they interact with are assumed to be macroscopic. This review discusses different theories which can take into account different aspects of mesoscopic and nanoscale physics, such as coherent quantum transport, magnetic-field induced effects (including topological ones such as the quantum Hall effect), and single electron charging effects. It discusses the efficiency of thermoelectric conversion, and the thermoelectric figure of merit. More specifically, the theories presented are (i) linear response theory with or without magnetic fields, (ii) Landauer scattering theory in the linear response regime and far from equilibrium, (iii) Green-Kubo formula for strongly interacting systems within the linear response regime, (iv) rate equation analysis for small quantum machines with or without interaction effects, (v) stochastic thermodynamic for fluctuating small systems. In all cases, we place particular emphasis on the fundamental questions about the bounds on ideal machines. Can magnetic-fields change the

[Fundamental aspects of extreme aging].

PubMed

Tréton, J

2002-07-01

Major developments in molecular biology in invertebrates have recently shown the determining effect of genetics on aging. The first finding was that artificial selection can highlight the genetic aspect of the aging process, demonstrating the polygenetic property of longevity. Another finding showed that certain gene transfers can modulate the lifespan of an organism. Recent progress has been made in three fields: genetic markers of aging, biological basis of cell maintenance, and hereditary factors contributing to late onset genetic disease. These new developments open new avenues of research in clinical biology. In regard to genetic markers of aging, it has been demonstrated that the ends of the chromosomes, telomeres, play a role in cell senescence. Telomeres can be viewed as markers of aging. Shortened telomeres are associated with replicative senescence and antitumor action. DNA anomalies are also more frequent: simple or double breaks, additions and base substitutions. Data on the biological basis of cell maintenance obtained in invertebrates show the polygenetic property of aging involving four significant mechanisms, control of metabolism, resistance to stress, chromatin-dependent gene regulation of genetic homeostasis. Finally, recent studies have shown that late onset hereditary diseases would be linked with particular genes, some of which have been identified. Two non-exclusive mechanisms could be involved: an adaptive mechanism involving gene selection during the evolutionary process, for example in obesity; and non-adaptive accumulation of gene expression during the post-reproductive phase, for example in Alzheimer's disease. These findings open a new era for the biology of aging.

Application of wave mechanics theory to fluid dynamics problems: Fundamentals

NASA Technical Reports Server (NTRS)

Krzywoblocki, M. Z. V.

1974-01-01

The application of the basic formalistic elements of wave mechanics theory is discussed. The theory is used to describe the physical phenomena on the microscopic level, the fluid dynamics of gases and liquids, and the analysis of physical phenomena on the macroscopic (visually observable) level. The practical advantages of relating the two fields of wave mechanics and fluid mechanics through the use of the Schroedinger equation constitute the approach to this relationship. Some of the subjects include: (1) fundamental aspects of wave mechanics theory, (2) laminarity of flow, (3) velocity potential, (4) disturbances in fluids, (5) introductory elements of the bifurcation theory, and (6) physiological aspects in fluid dynamics.

Thermodynamics fundamentals of energy conversion

NASA Astrophysics Data System (ADS)

Dan, Nicolae

The work reported in the chapters 1-5 focuses on the fundamentals of heat transfer, fluid dynamics, thermodynamics and electrical phenomena related to the conversion of one form of energy to another. Chapter 6 is a re-examination of the fundamental heat transfer problem of how to connect a finite-size heat generating volume to a concentrated sink. Chapter 1 extends to electrical machines the combined thermodynamics and heat transfer optimization approach that has been developed for heat engines. The conversion efficiency at maximum power is 1/2. When, as in specific applications, the operating temperature of windings must not exceed a specified level, the power output is lower and efficiency higher. Chapter 2 addresses the fundamental problem of determining the optimal history (regime of operation) of a battery so that the work output is maximum. Chapters 3 and 4 report the energy conversion aspects of an expanding mixture of hot particles, steam and liquid water. At the elemental level, steam annuli develop around the spherical drops as time increases. At the mixture level, the density decreases while the pressure and velocity increases. Chapter 4 describes numerically, based on the finite element method, the time evolution of the expanding mixture of hot spherical particles, steam and water. The fluid particles are moved in time in a Lagrangian manner to simulate the change of the domain configuration. Chapter 5 describes the process of thermal interaction between the molten material and water. In the second part of the chapter the model accounts for the irreversibility due to the flow of the mixture through the cracks of the mixing vessel. The approach presented in this chapter is based on exergy analysis and represents a departure from the line of inquiry that was followed in chapters 3-4. Chapter 6 shows that the geometry of the heat flow path between a volume and one point can be optimized in two fundamentally different ways. In the "growth" method the

Free electron laser and fundamental physics

NASA Astrophysics Data System (ADS)

Dattoli, Giuseppe; Nguyen, Federico

2018-03-01

This review paper is devoted to the understanding of free-electron lasers (FEL) as devices for fundamental physics (FP) studies. After clarifying what FP stands for, we select some aspects of the FEL physics which can be viewed as fundamental. Furthermore, we discuss the perspective uses of the FEL in FP experiments. Regarding the FP aspects of the FEL, we analyze the quantum electrodynamics (QED) nature of the underlying laser mechanism. We look for the truly quantum signature in a process whose phenomenology is dominated by classical effects. As to the use of FEL as a tool for FP experiments we discuss the realization of a device dedicated to the study of non-linear effects in QED such as photon-photon scattering and shining-through-the-wall experiments planned to search for dark matter candidates like axions.

3-[4-Bromo-α( R*)-methoxybenzyl]-6-chloro-3( S*),4( S*)-dihydroxychroman: X-ray and DFT Studies

NASA Astrophysics Data System (ADS)

Sepay, Nayim; Mondal, Rina; Guha, Chayan; Mallik, Asok K.

2018-05-01

Sodium borohydride reduction of E-3-benzylidenechromanone epoxides in dry methanol has afforded 3( S*), 4( S*)-dihydroxy-3-[α( R*)-methoxybenzyl]chromans as an interesting class of products, the structures of which have been assigned mainly from spectral data and consideration of the mechanistic aspects. X-ray diffraction study of one of them, 3-[4-bromo-α( R*)-methoxybenzyl]-6-chloro-3( S*),4( S*)- dihydroxychroman, is performed. The title compound crystallizes in the monoclinic sp. gr. P21/ n, with a = 13.336(6) Å, b = 10.866(5) Å, c = 27.166(11) Å, β = 95.193(6)°, V = 3920(3) Å3, and Z = 8. Supramolecular construction of the compound involves O-H···O intermolecular hydrogen bonds as well as three other types of non-covalent interactions which are responsible for crystal packing. Density functional theory was applied for geometry optimization, molecular orbital calculations, and prediction of UV spectral features. The geometric parameters (bond lengths, bond angles, and dihedral angles) for the representative compound obtained from density functional theory with B3LY6-31G basis set were in good agreement with experimental values.

An integration of integrated information theory with fundamental physics

PubMed Central

Barrett, Adam B.

2014-01-01

To truly eliminate Cartesian ghosts from the science of consciousness, we must describe consciousness as an aspect of the physical. Integrated Information Theory states that consciousness arises from intrinsic information generated by dynamical systems; however existing formulations of this theory are not applicable to standard models of fundamental physical entities. Modern physics has shown that fields are fundamental entities, and in particular that the electromagnetic field is fundamental. Here I hypothesize that consciousness arises from information intrinsic to fundamental fields. This hypothesis unites fundamental physics with what we know empirically about the neuroscience underlying consciousness, and it bypasses the need to consider quantum effects. PMID:24550877

String Theory on five dimensional Anti de Sitter space-times: Fundamental aspects and applications

NASA Astrophysics Data System (ADS)

Hofman, Diego M.

2009-12-01

In this thesis we study basic properties and applications of String Theory on AdS5 backgrounds. We do this in the framework of the AdS/CFT Correspondence and use our results to learn about four dimensional Conformal Field Theories. The first part of this work deals fundamentally with the problem of solving the exact spectrum of anomalous dimensions of planar N = 4 Super Yang Mills theory for all values of the 't Hooft coupling lambda. We study the problem for operators of large SO(6) charge J and identify the string configurations dual to magnons in the spin chain picture of the gauge theory. We name these states Giant Magnons. Furthermore we study their interactions and discuss the implications of the spectrum of states on the analytic structure of the exact scattering matrix of the theory. It is found that BPS states account for all the poles present in the full S-matrix. We also study the spectrum of Giant Magnons attached to D3-branes (Giant Gravitons). The dual operators in N = 4 SYM are long strings of SO(6) scalars connected to baryonic operators constructed of order N fields. The problem turns out to be mapped to solving the mulitparticle spectrum of a spin chain with non trivial boundary conditions. We study the properties of the boundary reflection matrix in detail and write equations that determine the associated phase factor. The second part of this work deals with applications of this type of string theories to the collider physics of conformal theories. We study infrared safe observables in the CFT given by energy correlation functions. We discuss the short distance behavior of these objects and explain that this physics is controlled by non local light ray operators. We find the dual String Theory description of these observables and use these results to study the strong coupling physics of conformal theories. We also describe the precise string states dual to the light ray operators. We argue that the energy operators that account for the energy

Aspect-Oriented Business Process Modeling with AO4BPMN

NASA Astrophysics Data System (ADS)

Charfi, Anis; Müller, Heiko; Mezini, Mira

Many crosscutting concerns in business processes need to be addressed already at the business process modeling level such as compliance, auditing, billing, and separation of duties. However, existing business process modeling languages including OMG's Business Process Modeling Notation (BPMN) lack appropriate means for expressing such concerns in a modular way. In this paper, we motivate the need for aspect-oriented concepts in business process modeling languages and propose an aspect-oriented extension to BPMN called AO4BPMN. We also present a graphical editor supporting that extension.

Ultraviolet spectroscopy of fundamental lignin subunits: guaiacol, 4-methylguaiacol, syringol, and 4-methylsyringol.

PubMed

Dean, Jacob C; Navotnaya, Polina; Parobek, Alexander P; Clayton, Rachel M; Zwier, Timothy S

2013-10-14

Ultraviolet spectroscopy of the G- and S-type lignin subunits, guaiacol (G) and syringol (S), along with their para-methylated derivatives 4-methylguaiacol (4-MG) and 4-methylsyringol (4-MS), has been carried out in the cold, isolated environment of a supersonic jet. The excitation spectra and dispersed fluorescence (DFL) spectra of G and 4-MG show strong S0-S1 origins and Franck-Condon activity involving both the ring modes typical of aromatic derivatives, and the four lowest frequency out-of-plane modes (a") and lowest in-plane mode (a') involving the OH and OCH3 groups. The four low-frequency out-of-plane modes undergo extensive Duschinsky mixing between the ground and excited state. In 4-MG, combination bands involving methyl rotor levels with out-of-plane modes appeared with surprisingly high intensity, indicating a high degree of hindered rotor-vibration coupling in both S0 and S1. These mixing effects accompany the change in geometry upon π-π∗ electronic excitation going from a planar ground state to a non-planar excited state. Time-dependent density functional theory (TDDFT M05-2X∕6-311++G(d,p)) calculations predict a geometric distortion along the out-of-plane oxygen flapping coordinate, yielding a double minimum potential in S1 with a barrier to planarity of 195 cm(-1) in G. The excitation spectrum of S and 4-MS showed a much higher degree of spectral congestion and a larger geometry change evident by a shifted intensity distribution peaking ∼300 cm(-1) above the electronic origin. TDDFT calculations predict a larger geometry change in S compared with G, with the OH and H-bonded methoxy groups displaced in opposite directions above∕below the ring plane. Dispersed fluorescence from all S1 excited state levels in S∕4-MS yield only broad emission peaking far to the red of the excitation wavelength (-4500 cm(-1)). Several hypotheses regarding the source of this broad, redshifted emission were tested, but the cause remains unclear. p

2nd International Symposium on Fundamental Aspects of Rare-earth Elements Mining and Separation and Modern Materials Engineering (REES-2015)

NASA Astrophysics Data System (ADS)

Tavadyan, Levon, Prof; Sachkov, Viktor, Prof; Godymchuk, Anna, Dr.; Bogdan, Anna

2016-01-01

The 2nd International Symposium «Fundamental Aspects of Rare-earth Elements Mining and Separation and Modern Materials Engineering» (REES2015) was jointly organized by Tomsk State University (Russia), National Academy of Science (Armenia), Shenyang Polytechnic University (China), Moscow Institute of Physics and Engineering (Russia), Siberian Physical-technical Institute (Russia), and Tomsk Polytechnic University (Russia) in September, 7-15, 2015, Belokuriha, Russia. The Symposium provided a high quality of presentations and gathered engineers, scientists, academicians, and young researchers working in the field of rare and rare earth elements mining, modification, separation, elaboration and application, in order to facilitate aggregation and sharing interests and results for a better collaboration and activity visibility. The goal of the REES2015 was to bring researchers and practitioners together to share the latest knowledge on rare and rare earth elements technologies. The Symposium was aimed at presenting new trends in rare and rare earth elements mining, research and separation and recent achievements in advanced materials elaboration and developments for different purposes, as well as strengthening the already existing contacts between manufactures, highly-qualified specialists and young scientists. The topics of the REES2015 were: (1) Problems of extraction and separation of rare and rare earth elements; (2) Methods and approaches to the separation and isolation of rare and rare earth elements with ultra-high purity; (3) Industrial technologies of production and separation of rare and rare earth elements; (4) Economic aspects in technology of rare and rare earth elements; and (5) Rare and rare earth based materials (application in metallurgy, catalysis, medicine, optoelectronics, etc.). We want to thank the Organizing Committee, the Universities and Sponsors supporting the Symposium, and everyone who contributed to the organization of the event and to

49 CFR 236.23 - Aspects and indications.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., MAINTENANCE, AND REPAIR OF SIGNAL AND TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Rules and Instructions: All Systems Roadway Signals and Cab Signals § 236.23 Aspects and indications. (a) Aspects shall be... with any other name and indication. (d) The fundamental indications of signal aspects shall conform to...

Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis.

PubMed

Tun, Aung Myint; Thein, Kyaw Zin; Myint, Zin War; Oo, Thein Hlaing

2017-11-08

Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Testing Our Fundamental Assumptions

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-06-01

fundamental assumptions.A recent focus set in the Astrophysical Journal Letters, titled Focus on Exploring Fundamental Physics with Extragalactic Transients, consists of multiple published studies doing just that.Testing General RelativitySeveral of the articles focus on the 4th point above. By assuming that the delay in photon arrival times is only due to the gravitational potential of the Milky Way, these studies set constraints on the deviation of our galaxys gravitational potential from what GR would predict. The study by He Gao et al. uses the different photon arrival times from gamma-ray bursts to set constraints at eVGeV energies, and the study by Jun-Jie Wei et al. complements this by setting constraints at keV-TeV energies using photons from high-energy blazar emission.Photons or neutrinos from different extragalactic transients each set different upper limits on delta gamma, the post-Newtonian parameter, vs. particle energy or frequency. This is a test of Einsteins equivalence principle: if the principle is correct, delta gamma would be exactly zero, meaning that photons of different energies move at the same velocity through a vacuum. [Tingay Kaplan 2016]S.J. Tingay D.L. Kaplan make the case that measuring the time delay of photons from fast radio bursts (FRBs; transient radio pulses that last only a few milliseconds) will provide even tighter constraints if we are able to accurately determine distances to these FRBs.And Adi Musser argues that the large-scale structure of the universe plays an even greater role than the Milky Way gravitational potential, allowing for even stricter testing of Einsteins equivalence principle.The ever-narrower constraints from these studies all support GR as a correct set of rules through which to interpret our universe.Other Tests of Fundamental PhysicsIn addition to the above tests, Xue-Feng Wu et al. show that FRBs can be used to provide severe constraints on the rest mass of the photon, and S. Croft et al. even touches on what we

Bandwidth Extension of an S-band, Fundamental-Mode Eight-Beam Klystron

DTIC Science & Technology

2006-04-01

Extension of an S - band , Fundamental-Mode Eight-Beam Klystron Khanh T. Nguyen Beam-Wave Research, Inc. Bethesda, MD 20814 Dean E. Pershing ATK Mission...of a five-cavity, approximately 18 cm downstream from the center of the broadband, high - power multiple-beam klystron (MBK) first gap - the logical...the circuit generates >550 kW across the band with a peak power of more than 600 kW at -3.27 Keywords: Multiple-beam klystron ; MBK; bandwidth GHz. The 1

Modeling the fundamental characteristics and processes of the spacecraft functioning

NASA Technical Reports Server (NTRS)

Bazhenov, V. I.; Osin, M. I.; Zakharov, Y. V.

1986-01-01

The fundamental aspects of modeling of spacecraft characteristics by using computing means are considered. Particular attention is devoted to the design studies, the description of physical appearance of the spacecraft, and simulated modeling of spacecraft systems. The fundamental questions of organizing the on-the-ground spacecraft testing and the methods of mathematical modeling were presented.

Mathematical Fundamentals of Probabilistic Semantics for High-Level Fusion

DTIC Science & Technology

2013-12-02

understanding of the fundamental aspects of uncertainty representation and reasoning that a theory of hard and soft high-level fusion must encompass...representation and reasoning that a theory of hard and soft high-level fusion must encompass. Successful completion requires an unbiased, in-depth...and soft information is the lack of a fundamental HLIF theory , backed by a consistent mathematical framework and supporting algorithms. Although there

Seven fundamental procedures for definitive correction of unilateral secondary cleft lip nasal deformity in soft tissue aspects.

PubMed

Lee, Dong Won; Choi, Bong-Kyoon; Park, Be-Young Yun

2011-11-01

It is accepted that patients who undergo appropriate primary repair for cleft lip will have secondary deformities. Because these deformities are caused by complex and diverse patterns, the deformities were categorized to provide a standardized treatment for each category. Pathologic characteristics of 1,170 patients were classified into 7 categories. Corrections were performed using 7 fundamental procedures corresponding to the surgical resolution of each deformity: 1) transposition of the caudal septum; 2) release of the septal-cartilaginous junction; 3) medial crus elevation; 4) lateral crus elevation; 5) release of the orbicularis oris muscle from the lip elevators; 6) anchoring of the orbicularis oris muscle to the anterior nasal spine; and 7) philtral column formation. A satisfaction survey was performed to evaluate the overall outcomes in 171 patients and an anthropometric analysis was performed in 38 patients. Satisfactory scores obtained through postoperative follow-up were higher than preoperative scores, and there was no difference between postoperative scores obtained over the short and long term. All preoperative anthropometric measurements were different from the postoperative measurements, indicating that the fundamental procedure achieved effective outcomes. These proposed 7 fundamental procedures can be used as guidelines that can always be applied for the correction of any secondary cleft lip nasal deformity to obtain ideal treatment outcomes. Copyright © 2011. Published by Elsevier Inc.

Arguing against fundamentality

NASA Astrophysics Data System (ADS)

McKenzie, Kerry

This paper aims to open up discussion on the relationship between fundamentality and naturalism, and in particular on the question of whether fundamentality may be denied on naturalistic grounds. A historico-inductive argument for an anti-fundamentalist conclusion, prominent within the contemporary metaphysical literature, is examined; finding it wanting, an alternative 'internal' strategy is proposed. By means of an example from the history of modern physics - namely S-matrix theory - it is demonstrated that (1) this strategy can generate similar (though not identical) anti-fundamentalist conclusions on more defensible naturalistic grounds, and (2) that fundamentality questions can be empirical questions. Some implications and limitations of the proposed approach are discussed.

Precision spectroscopy of the 2S-4P transition in atomic hydrogen

NASA Astrophysics Data System (ADS)

Maisenbacher, Lothar; Beyer, Axel; Matveev, Arthur; Grinin, Alexey; Pohl, Randolf; Khabarova, Ksenia; Kolachevsky, Nikolai; Hänsch, Theodor W.; Udem, Thomas

2017-04-01

Precision measurements of atomic hydrogen have long been successfully used to extract fundamental constants and to test bound-state QED. However, both these applications are limited by measurements of hydrogen lines other than the very precisely known 1S-2S transition. Moreover, the proton r.m.s.charge radius rp extracted from electronic hydrogen measurements currently disagrees by 4 σ with the much more precise value extracted from muonic hydrogen spectroscopy. We have measured the 2S-4P transition in atomic hydrogen using a cryogenic beam of hydrogen atoms optically excited to the initial 2S state. The first order Doppler shift of the one-photon 2S-4P transition is suppressed by actively stabilized counter-propagating laser beams and time-of-flight resolved detection. Quantum interference between excitation paths can lead to significant line distortions in our system. We use an experimentally verified, simple line shape model to take these distortions into account. With this, we can extract a new value for rp and the Rydberg constant R∞ with comparable accuracy as the combined previous H world data.

12. PIERS 5S AND 4S, SHOWING TRANSITION AT 4S FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. PIERS 5S AND 4S, SHOWING TRANSITION AT 4S FROM GIRDER SPAN TO 'SUSPENDED' TRUSS SPAN AT U0. VIEW LOOKING WEST. - George P. Coleman Memorial Bridge, Spanning York River at U.S. Route 17, Yorktown, York County, VA

Energies and spin states of FeS(0/-), FeS2(0/-), Fe2S2(0/-), Fe3S4(0/-), and Fe4S4(0/-) clusters.

PubMed

Li, Yan-Ni; Wang, Shengguang; Wang, Tao; Gao, Rui; Geng, Chun-Yu; Li, Yong-Wang; Wang, Jianguo; Jiao, Haijun

2013-04-15

The structures and energies of the electronic ground states of the FeS(0/-), FeS2(0/-), Fe2S2(0/-), Fe3S4(0/-), and Fe4S4(0/-) neutral and anionic clusters have been computed systematically with nine computational methods in combination with seven basis sets. The computed adiabatic electronic affinities (AEA) have been compared with available experimental data. Most reasonable agreements between theory and experiment have been found for both hybrid B3LYP and B3PW91 functionals in conjugation with 6-311+G* and QZVP basis sets. Detailed comparisons between the available experimental and computed AEA data at the B3LYP/6-311+G* level identified the electronic ground state of (5)Δ for FeS, (4)Δ for FeS(-), (5)B2 for FeS2, (6)A1 for FeS2(-), (1)A1 for Fe2S2, (8)A' for Fe2S2(-), (5)A'' for Fe3S4, (6)A'' for Fe3S4(-), (1)A1 for Fe4S4, and (1)A2 for Fe4S4(-). In addition, Fe2S2, Fe3S4, Fe3S4(-), Fe4S4, and Fe4S4(-) are antiferromagnetic at the B3LYP/6-311+G* level. The magnetic properties are discussed on the basis of natural bond orbital analysis. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fundamental problems in provable security and cryptography.

PubMed

Dent, Alexander W

2006-12-15

This paper examines methods for formally proving the security of cryptographic schemes. We show that, despite many years of active research and dozens of significant results, there are fundamental problems which have yet to be solved. We also present a new approach to one of the more controversial aspects of provable security, the random oracle model.

Relationship between fundamental motor skills and physical activity in 4-year-old preschool children.

PubMed

Iivonen, K S; Sääkslahti, A K; Mehtälä, A; Villberg, J J; Tammelin, T H; Kulmala, J S; Poskiparta, M

2013-10-01

This study evaluated the relationships between objectively measured physical activity and fundamental motor skills in 4-year-old children. Physical activity was monitored in 20 girls and 17 boys over 5 consecutive days (3 days at preschool and 2 days at home) and their fundamental motor skills measured. Multiple linear regressions controlled for sex, age, and body mass index indicated that the total skill score was significantly associated with physical activity, explaining 13%, 16%, and 16% of the variance in total, moderate-to-vigorous, and light-to-vigorous physical activity, respectively. Sliding and galloping were significantly associated with moderate-to-vigorous physical activity, and throwing and catching combination was significantly associated with total, moderate-to-vigorous, and light-to-vigorous physical activity. The findings warrant future investigations with larger samples to examine the relationship between locomotor, manipulative skills, and physical activity behaviors.

Triple-aspect monism: physiological, mental unconscious and conscious aspects of brain activity.

PubMed

Pereira, Alfredo

2014-06-01

Brain activity contains three fundamental aspects: (a) The physiological aspect, covering all kinds of processes that involve matter and/or energy; (b) the mental unconscious aspect, consisting of dynamical patterns (i.e., frequency, amplitude and phase-modulated waves) embodied in neural activity. These patterns are variously operated (transmitted, stored, combined, matched, amplified, erased, etc), forming cognitive and emotional unconscious processes and (c) the mental conscious aspect, consisting of feelings experienced in the first-person perspective and cognitive functions grounded in feelings, as memory formation, selection of the focus of attention, voluntary behavior, aesthetical appraisal and ethical judgment. Triple-aspect monism (TAM) is a philosophical theory that provides a model of the relation of the three aspects. Spatially distributed neuronal dendritic potentials generate amplitude-modulated waveforms transmitted to the extracellular medium and adjacent astrocytes, prompting the formation of large waves in the astrocyte network, which are claimed to both integrate distributed information and instantiate feelings. According to the valence of the feeling, the large wave feeds back on neuronal synapses, modulating (reinforcing or depressing) cognitive and behavioral functions.

Synthesis of ( 2S, 4S)-4-phenylamino-5-oxoproline derivatives.

PubMed

Nizova, I A; Krasnov, V P; Levit, G L; Kodess, M I

2002-01-01

The paper describes the synthesis of ( 2S, 4S)-4-(N-Ts)- and ( 2S, 4S)-4-(N-Boc)-phenylamino-5-oxoprolines (pyroglutamic acid). These derivatives have been shown to be useful for synthesis of their amides and peptides in spite of steric hindrances caused by bulky groups adjacent to the reaction centre. Under the conditions applied no lactam ring opening and no loss of stereochemical integrity of any of the chiral centres were observed, which has been confirmed by NMR techniques.

Regulatory Aspects of Smart Water Networks in the U.S.

EPA Science Inventory

The presentation addresses regulatory aspects of smart water networks in the U.S. It will be presented at the Smart Water Networks Forum (SWAN) annual conference in London, England from April 29-30, 2015. The conference will bring together key voices in the smart water space f...

The Particle Adventure | What is fundamental? | Fundamental

Science.gov Websites

fundamental The atom Is the atom fundamental? Is the nucleus fundamental? Are protons and neutrons fundamental decay What is the Mechanism giving mass to fundamental particles? What is the Mechanism giving mass to fundamental particles? Part 2 How Does the Higgs Boson get its Mass? Finding the Mass of the Higgs Boson

Liposculpture 4. Fundamentals of good liposculpture technique.

PubMed

Fischer, G

1992-03-01

The fundamentals for good liposculpture are discussed. Horizontal tunneling is to be avoided because the more horizontally the tunnel is angled, the more likely the overlying skin will drape in folds, resulting in poor cosmesis. Superficial tunneling (less than 1 cm) is to be avoided. The author believes that it is important to maintain the adhesive forces and lymphatics of the superficial layer of fat because it leads to more even healing and remodelling postoperatively. Liposuction within 3 cm of the subgluteal fold should be avoided because it can lead to ptosis of the buttocks postoperatively.

Subharmonic and fundamental high amplitude excitation of an axisymmetric jet

NASA Technical Reports Server (NTRS)

Raman, Ganesh; Rice, Edward J.

1989-01-01

A circular jet was excited simultaneously by two different harmonically related tones. Data for three pairs of Strouhal numbers (St(D) = f*D/U (sub j) = 0.2 and 0.4, 0.3 and 0.6, 0.4 and 0.8). For each case the initial phase difference between the two waves was varied in steps of 45 deg, for one full cycle and the level of the fundamental and subharmonic forcing were varied independently over the range of 0.1 to 7 percent of the jet exit velocity. Our initial findings concurred with published findings, such as a critical level of the fundamental is required for subharmonic augmentation, the initial phase difference is critical in determining whether the subharmonic is augmented or suppressed. The detailed documentation of several aspects of this phenomenon all measured in one and the same experimental facility in a controlled manner, bring out several important points that eluded previous researchers: (1) At high amplitudes of the fundamental and subharmonic forcing levels the subharmonic augmentation is independent of the initial phase difference. (2) Contrary to the earlier belief that stable pairing could be produced only with an initial laminar boundary layer, the present work shows that by the two-frequency excitation method this phenomenon can be induced over a range of conditions for a jet with an initially turbulent boundary layer. (3) It is seen that two-frequency excitation is indeed more effective than single frequency excitation in jet mixing enhancement. Higher spreading rates seem to go along with higher subharmonic levels.

Excitonic and band-band transitions of Cu2ZnSiS4 determined from reflectivity spectra

NASA Astrophysics Data System (ADS)

Guc, M.; Levcenko, S.; Dermenji, L.; Gurieva, G.; Schorr, S.; Syrbu, N. N.; Arushanov, E.

2014-07-01

Exciton spectra of Cu2ZnSiS4 single crystals are investigated by reflection spectroscopy at 10 and 300 K for light polarized perpendicular (E⊥c) and parallel (E∥c) to the optical axis. The parameters of the excitons and dielectric constant are determined. The free carriers effective masses have been estimated. The room temperature reflectivity spectra at photon energies higher than the fundamental band gap in the polarization Е⊥с and E∥с were measured and related to the electronic band structure of Cu2ZnSiS4.

PREFACE: Fundamental Neutron Physics: Introduction and Overview Fundamental Neutron Physics: Introduction and Overview

NASA Astrophysics Data System (ADS)

Holstein, Barry R.

2009-10-01

In the 77 years since its discovery by Chadwick in 1932, the neutron has come to play an increasingly important role in contemporary physics. As the next to lightest baryon, it is, of course, one of the two primary components of the atomic nucleus and studies of isotopes (nuclei with varying numbers of neutrons but the same proton number) and of the neutron drip line are one of the important focuses of the recently approved radioactive beam machine to be built at Michigan State University. Precise knowledge of its ~900 second lifetime is crucial to determination of the time at which nucleosynthesis occurs in the early universe. Because it is electrically neutral, the neutron can penetrate the atomic cloud and neutron scattering has become a powerful tool in the study of the structure of materials in condensed matter and biophysics. These are all important issues, but will not be addressed in the articles presented below. Rather, in the set of manuscripts published herein, we show various ways in which the neutron has come to probe fundamental questions in physics. We present six such articles: Because of its simple structure, neutron beta decay has served as a laboratory for the study of possible symmetry violations, including search for possible Script T-violation via measurement of the D coefficient, search for second class currents and/or possible CVC violation via examination of recoil terms, search for right-handed currents via examination of correlations, search for S, T couplings via measurement of the b parameter, etc. The study of neutron decay is reviewed in the article by Jeff Nico. The use of the neutron as a probe of possible Script T-violation via the existence of a non-zero electric dipole moment is discussed in the article by Steve Lamoreaux. The neutron is a prime player in the experimental study of hadronic parity violation, via experiments involving radiative capture and spin rotation, as examined in the article by Barry Holstein. Because of its

Fundamentals of quality and safety in diagnostic radiology.

PubMed

Bruno, Michael A; Nagy, Paul

2014-12-01

The most fundamental aspects of quality and safety in radiology are reviewed, including a brief history of the quality and safety movement as applied to radiology, the overarching considerations of organizational culture, team building, choosing appropriate goals and metrics, and the radiologist's quality "tool kit." Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Spectroscopic ellipsometry study of Cu2ZnSnS4 bulk poly-crystals

NASA Astrophysics Data System (ADS)

Levcenko, S.; Hajdeu-Chicarosh, E.; Garcia-Llamas, E.; Caballero, R.; Serna, R.; Bodnar, I. V.; Victorov, I. A.; Guc, M.; Merino, J. M.; Pérez-Rodriguez, A.; Arushanov, E.; León, M.

2018-04-01

The linear optical properties of Cu2ZnSnS4 bulk poly-crystals have been investigated using spectroscopic ellipsometry in the range of 1.2-4.6 eV at room temperature. The characteristic features identified in the optical spectra are explained by using the Adachi analytical model for the interband transitions at the corresponding critical points in the Brillouin zone. The experimental data have been modeled over the entire spectral range taking into account the lowest E0 transition near the fundamental absorption edge and E1A and E1B higher energy interband transitions. In addition, the spectral dependences of the refractive index, extinction coefficient, absorption coefficient, and normal-incidence reflectivity values have been accurately determined and are provided since they are essential data for the design of Cu2ZnSnS4 based optoelectronic devices.

Transformation of dinitrosyl iron complexes [(NO)2Fe(SR)2]- (R = Et, Ph) into [4Fe-4S] Clusters [Fe4S4(SPh)4]2-: relevance to the repair of the nitric oxide-modified ferredoxin [4Fe-4S] clusters.

PubMed

Tsou, Chih-Chin; Lin, Zong-Sian; Lu, Tsai-Te; Liaw, Wen-Feng

2008-12-17

Transformation of dinitrosyl iron complexes (DNICs) [(NO)(2)Fe(SR)(2)](-) (R = Et, Ph) into [4Fe-4S] clusters [Fe(4)S(4)(SPh)(4)](2-) in the presence of [Fe(SPh)(4)](2-/1-) and S-donor species S(8) via the reassembling process ([(NO)(2)Fe(SR)(2)](-) --> [Fe(4)S(3)(NO)(7)](-) (1)/[Fe(4)S(3)(NO)(7)](2-) (2) --> [Fe(4)S(4)(NO)(4)](2-) (3) --> [Fe(4)S(4)(SPh)(4)](2-) (5)) was demonstrated. Reaction of [(NO)(2)Fe(SR)(2)](-) (R = Et, Ph) with S(8) in THF, followed by the addition of HBF(4) into the mixture solution, yielded complex [Fe(4)S(3)(NO)(7)](-) (1). Complex [Fe(4)S(3)(NO)(7)](2-) (2), obtained from reduction of complex 1 by [Na][biphenyl], was converted into complex [Fe(4)S(4)(NO)(4)](2-) (3) along with byproduct [(NO)(2)Fe(SR)(2)](-) via the proposed [Fe(4)S(3)(SPh)(NO)(4)](2-) intermediate upon treating complex 2 with 1.5 equiv of [Fe(SPh)(4)](2-) and the subsequent addition of 1/8 equiv of S(8) in CH(3)CN at ambient temperature. Complex 3 was characterized by IR, UV-vis, and single-crystal X-ray diffraction. Upon addition of complex 3 to the CH(3)CN solution of [Fe(SPh)(4)](-) in a 1:2 molar ratio at ambient temperature, the rapid NO radical-thiyl radical exchange reaction between complex 3 and the biomimetic oxidized form of rubredoxin [Fe(SPh)(4)](-) occurred, leading to the simultaneous formation of [4Fe-4S] cluster [Fe(4)S(4)(SPh)(4)](2-) (5) and DNIC [(NO)(2)Fe(SPh)(2)](-). This result demonstrates a successful biomimetic reassembly of [4Fe-4S] cluster [Fe(4)S(4)(SPh)(4)](2-) from NO-modified [Fe-S] clusters, relevant to the repair of DNICs derived from nitrosylation of [4Fe-4S] clusters of endonuclease III back to [4Fe-4S] clusters upon addition of ferrous ion, cysteine, and IscS.

Fundamentals of Geophysics

NASA Astrophysics Data System (ADS)

Lowrie, William

1997-10-01

This unique textbook presents a comprehensive overview of the fundamental principles of geophysics. Unlike most geophysics textbooks, it combines both the applied and theoretical aspects to the subject. The author explains complex geophysical concepts using abundant diagrams, a simplified mathematical treatment, and easy-to-follow equations. After placing the Earth in the context of the solar system, he describes each major branch of geophysics: gravitation, seismology, dating, thermal and electrical properties, geomagnetism, paleomagnetism and geodynamics. Each chapter begins with a summary of the basic physical principles, and a brief account of each topic's historical evolution. The book will satisfy the needs of intermediate-level earth science students from a variety of backgrounds, while at the same time preparing geophysics majors for continued study at a higher level.

Computational Aeroelastic Analysis of the Semi-Span Super-Sonic Transport (S4T) Wind-Tunnel Model

NASA Technical Reports Server (NTRS)

Sanetrik, Mark D.; Silva, Walter A.; Hur, Jiyoung

2012-01-01

A summary of the computational aeroelastic analysis for the Semi-Span Super-Sonic Transport (S4T) wind-tunnel model is presented. A broad range of analysis techniques, including linear, nonlinear and Reduced Order Models (ROMs) were employed in support of a series of aeroelastic (AE) and aeroservoelastic (ASE) wind-tunnel tests conducted in the Transonic Dynamics Tunnel (TDT) at NASA Langley Research Center. This research was performed in support of the ASE element in the Supersonics Program, part of NASA's Fundamental Aeronautics Program. The analysis concentrated on open-loop flutter predictions, which were in good agreement with experimental results. This paper is one in a series that comprise a special S4T technical session, which summarizes the S4T project.

Joint Rhythmic Movement Increases 4-Year-Old Children’s Prosocial Sharing and Fairness Toward Peers

PubMed Central

Rabinowitch, Tal-Chen; Meltzoff, Andrew N.

2017-01-01

The allocation of resources to a peer partner is a prosocial act that is of fundamental importance. Joint rhythmic movement, such as occurs during musical interaction, can induce positive social experiences, which may play a role in developing and enhancing young children’s prosocial skills. Here, we investigated whether joint rhythmic movement, free of musical context, increases 4-year-olds’ sharing and sense of fairness in a resource allocation task involving peers. We developed a precise procedure for administering joint synchronous experience, joint asynchronous experience, and a baseline control involving no treatment. Then we tested how participants allocated resources between self and peer. We found an increase in the generous allocation of resources to peers following both synchronous and asynchronous movement compared to no treatment. At a more theoretical level, this result is considered in relation to previous work testing other aspects of child prosociality, for example, peer cooperation, which can be distinguished from judgments of fairness in resource allocation tasks. We draw a conceptual distinction between two types of prosocial behavior: resource allocation (an other-directed individual behavior) and cooperation (a goal-directed collaborative endeavor). Our results highlight how rhythmic interactions, which are prominent in joint musical engagements and synchronized activity, influence prosocial behavior between preschool peers. PMID:28694786

A comparison of a child’s fundamental frequencies in structured elicited vocalizations versus unstructured natural vocalizations: A case study

PubMed Central

Hunter, Eric J.

2009-01-01

Objectives Building on the concept that task type may influence fundamental frequency (F0) values, the purpose of this case study was to investigate the difference in a child’s F0 during structured, elicited tasks and long-term, unstructured activities. It also explores the possibility that the distribution in children’s F0 may make the standard statistical measures of mean and standard deviation less than ideal metrics. Methods A healthy male child (5 years, 7 months) was evaluated. The child completed four voice tasks used in a previous study of the influence of task type on F0 values: (1) sustaining the vowel /a/; (2) sustaining the vowel, /a/, embedded in a word at the end of a phrase; (3) repeating a sentence; and (4) counting from 1 to 10. The child also wore a National Center for Voice and Speech voice dosimeter, a device that collects voice data over the course of an entire day, during all activities for 34 hours over 4 days. Results Throughout the structured vocal tasks within the clinical environment, the child’s F0, as measured by both the dosimeter and acoustic analysis of microphone data, was similar for all four tasks, with the counting task the most dissimilar. The mean F0 (~257 Hz) matched very closely to the average task results in the literature given for the child’s age group. However, the child’s mean fundamental frequency during the unstructured activities was significantly higher (~376 Hz). Finally, the mode and median of the structured vocal tasks were respectively 260 Hz and 259 Hz (both near the mean), while the unstructured mode and median were respectively 290 Hz and 355 Hz. Conclusions The results of this study suggest that children may produce a notably different voice pattern during clinical observations compared to routine daily activities. In addition, the child’s long-term F0 distribution is not normal. If this distribution is consistent in long-term, unstructured natural vocalization patterns of children, statistical

Optoelectronic properties of candidate photovoltaic Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 semiconductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nhalil, Hariharan; Han, Dan; Du, Mao-Hua

High temperature synthesis and optical band gaps are reported for three candidate photovoltaic earth-abundant Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 semiconductors. The reported synthesis method is found to be more advantageous for KAg 2SbS 4 compared to the literature reported synthesis utilizing supercritical ammonia as a reaction medium, which produces a mixture of chalcogenide products. Based on optical diffuse reflectance data, Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 have band gaps in the 1.6–1.8 eV range, and are shown to be stable in ambient air for a period of 6 weeks, making themmore » attractive candidates for solar cell applications. Density functional theory (DFT) calculations indicate indirect band gaps for Cu 2PbSiS 4 and KAg 2SbS 4, and a nearly direct band gap for Ag 2PbGeS 4 with the calculated difference between indirect and direct gaps of only 30 meV. The p-type semiconducting behavior of Cu 2PbSiS 4, Ag 2PbGeS 4 is also verified by the transport measurments. The 3D connectivity of the polyanionic networks in these compounds results in dispersive valence and conduction bands, which is especially noticeable for KAg 2SbS 4. This fact is in part attributed to the presence of formally pentavalent SbV in this compound leading to empty Sb 5s orbitals in the conduction band. Finally, we discuss the potential of Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 for photovoltaic applications based on synthesis, stability, band gap and electronic structure considerations.« less

Optoelectronic properties of candidate photovoltaic Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 semiconductors

DOE PAGES

Nhalil, Hariharan; Han, Dan; Du, Mao-Hua; ...

2018-03-01

High temperature synthesis and optical band gaps are reported for three candidate photovoltaic earth-abundant Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 semiconductors. The reported synthesis method is found to be more advantageous for KAg 2SbS 4 compared to the literature reported synthesis utilizing supercritical ammonia as a reaction medium, which produces a mixture of chalcogenide products. Based on optical diffuse reflectance data, Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 have band gaps in the 1.6–1.8 eV range, and are shown to be stable in ambient air for a period of 6 weeks, making themmore » attractive candidates for solar cell applications. Density functional theory (DFT) calculations indicate indirect band gaps for Cu 2PbSiS 4 and KAg 2SbS 4, and a nearly direct band gap for Ag 2PbGeS 4 with the calculated difference between indirect and direct gaps of only 30 meV. The p-type semiconducting behavior of Cu 2PbSiS 4, Ag 2PbGeS 4 is also verified by the transport measurments. The 3D connectivity of the polyanionic networks in these compounds results in dispersive valence and conduction bands, which is especially noticeable for KAg 2SbS 4. This fact is in part attributed to the presence of formally pentavalent SbV in this compound leading to empty Sb 5s orbitals in the conduction band. Finally, we discuss the potential of Cu 2PbSiS 4, Ag 2PbGeS 4 and KAg 2SbS 4 for photovoltaic applications based on synthesis, stability, band gap and electronic structure considerations.« less

AdS/CFT beyond the N = 4 SYM paradigm

NASA Astrophysics Data System (ADS)

Pomoni, Elli

In this thesis we present studies in the AdS/CFT correspondence that intend to push the present knowledge beyond the N = 4 super Yang-Mills (SYM) paradigm. The first part is concerned with the study of non-supersymmetric deformations of N = 4 SYM (which still are in the N = 4 universality class). For non-supersymmetric CFT's at Large N we explore the correspondence between string theory tachyons in the bulk and instabilities on the boundary effective action. The operators dual to AdS tachyons have anomalous dimensions that are purely complex numbers. We give a prescription for calculating the mass of the tachyon from the field theory side. Moreover, we apply this general dictionary to the case of intersecting D7 flavor branes in AdS 5 x S5 and obtain the mass of the open string tachyon that is dual to the instability in the mesonic sector of the theory. In the second part we present work aiming at finding string theory duals for gauge theories beyond the N = 4 universality class, i.e. theories that have genuinely less supersymmetry and unquenched flavor. Arguably the next simplest example after N = 4 SYM is N = 2 SU(Nc) SYM coupled to Nf = 2Nc fundamental hypermultiplets. The theory admits a Veneziano expansion of large Nc and large Nf, with Nf/Nc and lambda = g2Nc kept fixed. The topological structure of large N diagrams invites a general conjecture: the flavor-singlet sector of a gauge theory in the Veneziano limit is dual to a closed string theory. We present the one-loop Hamiltonian for the scalar sector of N = 2 superconformal QCD and study this integrability of the theory. Furthermore, we explore the chiral spectrum of the protected operators of the theory using the one-loop anomalous dimensions and, additionally, by studying the index of the theory. We finally search for possible AdS dual trying to match the chiral spectrum. We conclude that the string dual is a sub-critical background containing both an AdS 5 and an S1 factor.

Protonation and Proton-Coupled Electron Transfer at S-Ligated [4Fe-4S] Clusters

PubMed Central

Morris, Wesley D.; Darcy, Julia W.; Mayer, James M.

2015-01-01

Biological [Fe-S] clusters are increasingly recognized to undergo proton-coupled electron transfer (PCET), but the site of protonation, mechanism, and role for PCET remains largely unknown. Here we explore this reactivity with synthetic model clusters. Protonation of the arylthiolate-ligated [4Fe-4S] cluster [Fe4S4(SAr)4]2- (1, SAr = S-2,4-6-(iPr)3C6H2) leads to thiol dissociation, reversibly forming [Fe4S4(SAr)3L]1- (2) + ArSH (L = solvent, and/or conjugate base). Solutions of 2 + ArSH react with the nitroxyl radical TEMPO to give [Fe4S4(SAr)4]1- (1ox) and TEMPOH. This reaction involves PCET coupled to thiolate association and may proceed via the unobserved protonated cluster [Fe4S4(SAr)3(HSAr)]1-(1-H). Similar reactions with this and related clusters proceed comparably. An understanding of the PCET thermochemistry of this cluster system has been developed, encompassing three different redox levels and two protonation states. PMID:25965413

Rectenna session: Micro aspects. [energy conversion

NASA Technical Reports Server (NTRS)

Gutmann, R. J.

1980-01-01

Two micro aspects of the rectenna design are addressed: evaluation of the degradation in net rectenna RF to DC conversion efficiency due to power density variations across the rectenna (power combining analysis) and design of Yagi-Uda receiving elements to reduce rectenna cost by decreasing the number of conversion circuits (directional receiving elements). The first of these micro aspects involves resolving a fundamental question of efficiency potential with a rectenna, while the second involves a design modification with a large potential cost saving.

Fundamentals of affinity cell separations.

PubMed

Zhang, Ye; Lyons, Veronica; Pappas, Dimitri

2018-03-01

Cell separations using affinity methods continue to be an enabling science for a wide variety of applications. In this review, we discuss the fundamental aspects of affinity separation, including the competing forces for cell capture and elution, cell-surface interactions, and models for cell adhesion. Factors affecting separation performance such as bond affinity, contact area, and temperature are presented. We also discuss and demonstrate the effects of nonspecific binding on separation performance. Metrics for evaluating cell separations are presented, along with methods of comparing separation techniques for cell isolation using affinity capture. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An Overview of the Semi-Span Super-Sonic Transport (S4T) Wind-Tunnel Model Program

NASA Technical Reports Server (NTRS)

Silva, Walter A.; Perry, Boyd, III; Florance, James R.; Sanetrik, Mark D.; Wieseman, Carol D.; Stevens, William L.; Funk, Christie J.; Christhilf, David M.; Coulson, David A.

2012-01-01

A summary of computational and experimental aeroelastic (AE) and aeroservoelastic (ASE) results for the Semi-Span Super-Sonic Transport (S4T) wind-tunnel model is presented. A broad range of analyses and multiple AE and ASE wind-tunnel tests of the S4T wind-tunnel model have been performed in support of the ASE element in the Supersonics Program, part of the NASA Fundamental Aeronautics Program. This paper is intended to be an overview of multiple papers that comprise a special S4T technical session. Along those lines, a brief description of the design and hardware of the S4T wind-tunnel model will be presented. Computational results presented include linear and nonlinear aeroelastic analyses, and rapid aeroelastic analyses using CFD-based reduced-order models (ROMs). A brief survey of some of the experimental results from two open-loop and two closed-loop wind-tunnel tests performed at the NASA Langley Transonic Dynamics Tunnel (TDT) will be presented as well.

Collision-induced dissociation of [4Fe-4S] cubane cluster complexes: [Fe4S4Cl4 - x(SC2H5)x]2-/1- (x = 0-4)

NASA Astrophysics Data System (ADS)

Fu, You-Jun; Laskin, Julia; Wang, Lai-Sheng

2006-09-01

Collision-induced dissociation (CID) experiments on a series of [4Fe-4S] cluster ions, [Fe4S4Cl4 - x(SC2H5)x]2-/1- (x = 0-4), revealed that their fragmentation channels change with the coordination environment. Among the three Coulomb repulsion related channels for the doubly charged species, the collision induced electron detachment channel was found to become more significant from x = 0 to 4 due to the decreasing electron binding energies and the magnitude of repulsion Coulomb barrier, while both the ligand detachment of Cl- and the fission of the [Fe4S4]2+ core became more and more significant with the increase of the Cl- coordination, and eventually became the dominant channel at x = 0. From the parents containing the SC2H5 ligand, neutral losses of HSC2H5 (62 u) and/or HSCHCH2 (60 u) were observed. It was proposed that inter- and intra-ligand proton transfer could happen during the CID process, resulting in hydrogen coordination to the [4Fe-4S] cluster. In the presence of O2, [Fe4S4Cl3(SC2H5)]2- and [Fe4S4Cl4]2- can form the O2-substituted products [Fe4S4Cl2(SC2H5)O2]- and [Fe4S4Cl3O2]-, respectively. It was shown that the O2 complexation occurs by coordination to the empty iron site of the [4Fe-4S] cubane core after dissociation of one Cl- ligand.

[Fundamental aspects in the choice of renal replacement therapy].

PubMed

González Calvo, Carlos; Alvarez Rodríguez, Lucía

2016-01-01

Chronic kidney disease (CKD) is a disease with a high prevalence in our environment, and those suffering the disease should be as clear as possible that renal replacement therapy (RRT) may better suit your lifestyle. It is important that the patient has enough information about the techniques that can be accessed in a clear manner, so as to evaluate the different possibilities, advantages and disadvantages. The timing on this election is crucial and stressful for the patient's life, not only by the effects of the disease itself, but also by the assimilation of a new lifestyle that should keep the rest of it. This work was done thinking about the need for patients and health professionals in acquiring a holistic and comprehensive understanding of all the features that can have both peritoneal dialysis (PD) and hemodialysis (HD); form own patient factors (diet, family environment, etc.) related to nurses (care, information provided, etc.) without forgetting the conditions outside the patient and the nurse as they can be structural and economic aspects.

Effectiveness of a Fundamental Motor Skill Intervention for 4-Year-Old Children with Autism Spectrum Disorder: A Pilot Study

ERIC Educational Resources Information Center

Bremer, Emily; Balogh, Robert; Lloyd, Meghann

2015-01-01

A wait-list control experimental design was employed to investigate the effectiveness of a fundamental motor skill intervention at improving the motor skills, adaptive behavior, and social skills of 4-year-old children with autism spectrum disorder (experimental n?=?5, control n?=?4); the impact of intervention intensity was also explored. The…

26 CFR 1.338-4 - Aggregate deemed sale price; various aspects of taxation of the deemed asset sale.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Aggregate deemed sale price; various aspects of taxation of the deemed asset sale. 1.338-4 Section 1.338-4 Internal Revenue INTERNAL REVENUE SERVICE... Aggregate deemed sale price; various aspects of taxation of the deemed asset sale. (a) Scope. This section...

The Legal Aspects of Educational Planning and Administration. Fundamentals of Educational Planning.

ERIC Educational Resources Information Center

Durand-Prinborgne, Claude

The purpose of this monograph, which is aimed at educational planners, is to explain the essential aspects of the relationship between planning and law. It is intended to illustrate the role of law in the planning and administration of school systems and thus familiarize education specialists with the tools needed to understand legal…

Radar cross section fundamentals for the aircraft designer

NASA Technical Reports Server (NTRS)

Stadmore, H. A.

1979-01-01

Various aspects of radar cross-section (RCS) techniques are summarized, with emphasis placed on fundamental electromagnetic phenomena, such as plane and spherical wave formulations, and the definition of RCS is given in the far-field sense. The basic relationship between electronic countermeasures and a signature level is discussed in terms of the detectability range of a target vehicle. Fundamental radar-signature analysis techniques, such as the physical-optics and geometrical-optics approximations, are presented along with examples in terms of aircraft components. Methods of analysis based on the geometrical theory of diffraction are considered and various wave-propagation phenomena are related to local vehicle geometry. Typical vehicle components are also discussed, together with their contribution to total vehicle RCS and their individual signature sensitivities.

The Concept of Ideology in Analysis of Fundamental Questions in Science Education

NASA Astrophysics Data System (ADS)

Säther, Jostein

The use of the concept of `ideology' in interpretation of science education curricula, textbooks and various practises is reviewed, and examples are given by referring to Norwegian curricula and textbooks. The term is proposed to be used in a broad sense about any kind of action-oriented theory based on a system of ideas, or any attempt to approach politics in the light of a system of ideas. Politics in this context is about shaping of education, and is related to forces (i.e., hypothetical impacts of idea systems) which may legitimise, change, or criticise social practices. The focus is (although not in every case) on the hidden, unconscious and critical aspects. The notion ideological aspects is proposed to be related to metaphysical-ontological, epistemological and axiological claims and connotations. Examples of educational issues concerning e.g., aims, compartmentalisation, integration, and fundamentally different ideas about truth, learning and man are mentioned. Searching for a single and unifying concept for the discussing of all of science education's fundamental questions seems however in vain. Therefore a wide range of concepts seems necessary to deepen our understanding of ``the fundamental questions''.

Fundamental ecology is fundamental.

PubMed

Courchamp, Franck; Dunne, Jennifer A; Le Maho, Yvon; May, Robert M; Thébaud, Christophe; Hochberg, Michael E

2015-01-01

The primary reasons for conducting fundamental research are satisfying curiosity, acquiring knowledge, and achieving understanding. Here we develop why we believe it is essential to promote basic ecological research, despite increased impetus for ecologists to conduct and present their research in the light of potential applications. This includes the understanding of our environment, for intellectual, economical, social, and political reasons, and as a major source of innovation. We contend that we should focus less on short-term, objective-driven research and more on creativity and exploratory analyses, quantitatively estimate the benefits of fundamental research for society, and better explain the nature and importance of fundamental ecology to students, politicians, decision makers, and the general public. Our perspective and underlying arguments should also apply to evolutionary biology and to many of the other biological and physical sciences. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Theoretical Counseling Orientation: An Initial Aspect of Professional Orientation and Identity

ERIC Educational Resources Information Center

Jackson, James Lloyd, Jr.

2010-01-01

The literature on counselor development suggests that the development of a professional identity is a fundamental aspect of counselor training. The unique demands placed on counselors to integrate aspects of both personal and professional identity into the therapeutic process (Skovholt & Ronnestad, 1995) make development of a professional…

Interpreting Measures of Fundamental Movement Skills and Their Relationship with Health-Related Physical Activity and Self-Concept

ERIC Educational Resources Information Center

Jarvis, Stuart; Williams, Morgan; Rainer, Paul; Jones, Eleri Sian; Saunders, John; Mullen, Richard

2018-01-01

The aims of this study were to determine proficiency levels of fundamental movement skills using cluster analysis in a cohort of U.K. primary school children; and to further examine the relationships between fundamental movement skills proficiency and other key aspects of health-related physical activity behavior. Participants were 553 primary…

Fundamental bands of S(32)O2(16)

NASA Technical Reports Server (NTRS)

Fox, K.; Tejwani, G. D. T.; Corice, R. J., Jr.

1972-01-01

The infrared-active vibration-rotation fundamentals of sulfur dioxide were measured with moderately high spectral resolution. Quantum number assignments were made for spectral lines from J = O to 57, by comparison with theoretically computed spectra which include the effects of centrifugal distortion. The following values for the band centers were determined: nu sub 1 = 1151.65 + or - 0.10/cm, nu sub 2 = 517.75 + or - 0.10/cm, and nu sub 3 = 1362.00 + or - 0.10/cm. Intensities of the observed lines have also been computed. Dipole moment derivatives were obtained.

PIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

NASA Astrophysics Data System (ADS)

Kasimova, Marina A.; Zaydman, Mark A.; Cui, Jianmin; Tarek, Mounir

2015-01-01

Among critical aspects of voltage-gated potassium (Kv) channels' functioning is the effective communication between their two composing domains, the voltage sensor (VSD) and the pore. This communication, called coupling, might be transmitted directly through interactions between these domains and, as recently proposed, indirectly through interactions with phosphatidylinositol-4,5-bisphosphate (PIP2), a minor lipid of the inner plasma membrane leaflet. Here, we show how the two components of coupling, mediated by protein-protein or protein-lipid interactions, both contribute in the Kv7.1 functioning. On the one hand, using molecular dynamics simulations, we identified a Kv7.1 PIP2 binding site that involves residues playing a key role in PIP2-dependent coupling. On the other hand, combined theoretical and experimental approaches have shown that the direct interaction between the segments of the VSD (S4-S5) and the pore (S6) is weakened by electrostatic repulsion. Finally, we conclude that due to weakened protein-protein interactions, the PIP2-dependent coupling is especially prominent in Kv7.1.

Differences in Motivations between Fundamental Christians and Atheists on the Reiss Profile of Fundamental Goals and Motivational Sensitivities.

ERIC Educational Resources Information Center

Beasley, Amy; Rowell, Kevin

A study examined differences in motivations between fundamental Christians and atheists on the Reiss Profile of Fundamental Goals and Motivational Sensitivities. Only five of the 15 areas measured by the Reiss Profile were used in the study. The hypothesis was that (within these areas: (1) independence, (2) power, (3) vengeance, (4) status, and…

Two-dimensional protein crystals (S-layers): fundamentals and applications.

PubMed

Sleytr, U B; Sára, M; Messner, P; Pum, D

1994-10-01

Two-dimensional crystalline surface layers (S-layers) composed of protein or glycoprotein subunits are one of the most commonly observed prokaryotic cell envelope structures. Isolated S-layer subunits are endowed with the ability to assemble into monomolecular arrays in suspension, on surfaces or interfaces by an entropy-driven process. S-layer lattices are isoporous structures with functional groups located on the surface in an identical position and orientation. These characteristic features have already led to applications of S-layers as (1) ultrafiltration membranes with well-defined molecular weight cut-offs and excellent antifouling characteristics, (2) immobilization matrices for functional molecules as required for affinity and enzyme membranes, affinity microcarriers and biosensors, (3) conjugate vaccines, (4) carriers for Langmuir-Blodgett films and reconstituted biological membranes, and (5) patterning elements in molecular nanotechnology.

Structural principles for computational and de novo design of 4Fe-4S metalloproteins

PubMed Central

Nanda, Vikas; Senn, Stefan; Pike, Douglas H.; Rodriguez-Granillo, Agustina; Hansen, Will; Khare, Sagar D.; Noy, Dror

2017-01-01

Iron-sulfur centers in metalloproteins can access multiple oxidation states over a broad range of potentials, allowing them to participate in a variety of electron transfer reactions and serving as catalysts for high-energy redox processes. The nitrogenase FeMoCO cluster converts di-nitrogen to ammonia in an eight-electron transfer step. The 2(Fe4S4) containing bacterial ferredoxin is an evolutionarily ancient metalloprotein fold and is thought to be a primordial progenitor of extant oxidoreductases. Controlling chemical transformations mediated by iron-sulfur centers such as nitrogen fixation, hydrogen production as well as electron transfer reactions involved in photosynthesis are of tremendous importance for sustainable chemistry and energy production initiatives. As such, there is significant interest in the design of iron-sulfur proteins as minimal models to gain fundamental understanding of complex natural systems and as lead-molecules for industrial and energy applications. Herein, we discuss salient structural characteristics of natural iron-sulfur proteins and how they guide principles for design. Model structures of past designs are analyzed in the context of these principles and potential directions for enhanced designs are presented, and new areas of iron-sulfur protein design are proposed. PMID:26449207

The AdS/CFT Correspondence: Classical, Quantum, and Thermodynamical Aspects

NASA Astrophysics Data System (ADS)

Young, Donovan

2007-06-01

Certain aspects of the AdS/CFT correspondence are studied in detail. We investigate the one-loop mass shift to certain two-impurity string states in light-cone string field theory on a plane wave background. We find that there exist logarithmic divergences in the sums over intermediate mode numbers which cancel between the cubic Hamiltonian and quartic "contact term". We argue that generically, every order in intermediate state impurities contributes to the mass shift at leading perturbative order. The same mass shift is also computed using an improved 3-string vertex proposed by Dobashi and Yoneya. The result is found to agree with gauge theory at leading order and is close but not quite in agreement at subleading order. We extend the analysis to include discrete light-cone quantization, considering states with up to three units of p+. We study the (apparently) first-order phase transition in the weakly coupled plane-wave matrix model at finite temperature. We analyze the effect of interactions by computing the relevant parts of the effective potential for the Polyakov loop operator to three loop order. We show that the phase transition is indeed of first order. We also compute the 2-loop correction to the Hagedorn temperature. Finally, correlation functions of 1/4 BPS Wilson loops with the infinite family of 1/2 BPS chiral primary operators are computed in N=4 super Yang-Mills theory by summing planar ladder diagrams. The correlation functions are also computed in the strong-coupling limit using string theory; the result is found to agree with the extrapolation of the planar ladders. The result is related to similar correlators of 1/2 BPS loops by a simple re-scaling of the coupling constant, discovered by Drukker for the case of the 1/4 BPS loop VEV.

Integration of LCoS-SLM and LabVIEW based software to simulate fundamental optics, wave optics, and Fourier optics

NASA Astrophysics Data System (ADS)

Lyu, Bo-Han; Wang, Chen; Tsai, Chun-Wei

2017-08-01

Jasper Display Corp. (JDC) offer high reflectivity, high resolution Liquid Crystal on Silicon - Spatial Light Modulator (LCoS-SLM) which include an associated controller ASIC and LabVIEW based modulation software. Based on this LCoS-SLM, also called Education Kit (EDK), we provide a training platform which includes a series of optical theory and experiments to university students. This EDK not only provides a LabVIEW based operation software to produce Computer Generated Holograms (CGH) to generate some basic diffraction image or holographic image, but also provides simulation software to verity the experiment results simultaneously. However, we believe that a robust LCoSSLM, operation software, simulation software, training system, and training course can help students to study the fundamental optics, wave optics, and Fourier optics more easily. Based on these fundamental knowledges, they could develop their unique skills and create their new innovations on the optoelectronic application in the future.

Arabidopsis thaliana Nfu2 accommodates [2Fe-2S] or [4Fe-4S] clusters and is competent for in vitro maturation of chloroplast [2Fe-2S] and [4Fe-4S] cluster-containing proteins†

PubMed Central

Gao, Huanyao; Subramanian, Sowmya; Couturier, Jérémy; Naik, Sunil; Kim, Sung-Kun; Leustek, Thomas; Knaff, David B.; Wu, Hui-Chen; Vignols, Florence; Huynh, Boi Hanh; Rouhier, Nicolas; Johnson, Michael K.

2013-01-01

Nfu-type proteins are essential in the biogenesis of iron-sulfur (Fe-S) clusters in numerous organisms. A number of phenotypes including low levels of Fe-S cluster incorporation are associated with deletion of the gene encoding a chloroplast-specific Nfu-type protein, Nfu2 from Arabidopsis thaliana (AtNfu2). Here we report that recombinant AtNfu2 is able to assemble both [2Fe-2S] and [4Fe-4S] clusters. Analytical data and gel filtration studies support cluster/protein stoichiometries of one [2Fe-2S] cluster/homotetramer and one [4Fe-4S] cluster/homodimer. The combination of UV-visible absorption and circular dichroism, resonance Raman and Mössbauer spectroscopies has been employed to investigate the nature, properties and transfer of the clusters assembled on Nfu2. The results are consistent with subunit-bridging [2Fe-2S]2+ and [4Fe-4S]2+ clusters coordinated by the cysteines in the conserved CXXC motif. The results also provided insight into the specificity of Nfu2 for maturation of chloroplastic Fe-S proteins via intact, rapid and quantitative cluster transfer. [2Fe-2S] cluster-bound Nfu2 is shown to be an effective [2Fe-2S]2+ cluster donor for glutaredoxin S16, but not glutaredoxin S14. Moreover, [4Fe-4S] cluster-bound Nfu2 is shown to be a very rapid and efficient [4Fe-4S]2+ cluster donor for adenosine 5′-phosphosulfate reductase (APR1) and yeast two-hybrid studies indicate that APR1 forms a complex with Nfu2, but not with Nfu1 and Nfu3, the two other chloroplastic Nfu proteins. This cluster transfer is likely to be physiologically relevant and is particularly significant for plant metabolism as APR1 catalyzes the second step in reductive sulfur assimilation which ultimately results in the biosynthesis of cysteine, methionine, glutathione, and Fe-S clusters. PMID:24032747

Fundamental care guided by the Careful Nursing Philosophy and Professional Practice Model©.

PubMed

Meehan, Therese Connell; Timmins, Fiona; Burke, Jacqueline

2018-02-05

To propose the Careful Nursing Philosophy and Professional Practice Model © as a conceptual and practice solution to current fundamental nursing care erosion and deficits. There is growing awareness of the crucial importance of fundamental care. Efforts are underway to heighten nurses' awareness of values that motivate fundamental care and thereby increase their attention to effective provision of fundamental care. However, there remains a need for nursing frameworks which motivate nurses to bring fundamental care values to life in their practice and strengthen their commitment to provide fundamental care. This descriptive position paper builds on the Careful Nursing Philosophy and Professional Practice Model © (Careful Nursing). Careful Nursing elaborates explicit nursing values and addresses both relational and pragmatic aspects of nursing practice, offering an ideal guide to provision of fundamental nursing care. A comparative alignment approach is used to review the capacity of Careful Nursing to address fundamentals of nursing care. Careful Nursing provides a value-based comprehensive and practical framework which can strengthen clinical nurses' ability to articulate and control their practice and, thereby, more effectively fulfil their responsibility to provide fundamental care and measure its effectiveness. This explicitly value-based nursing philosophy and professional practice model offers nurses a comprehensive, pragmatic and engaging framework designed to strengthen their control over their practice and ability to provide high-quality fundamental nursing care. © 2018 John Wiley & Sons Ltd.

[3Fe-4S] to [4Fe-4S] cluster conversion in Desulfovibrio fructosovorans [NiFe] hydrogenase by site-directed mutagenesis.

PubMed

Rousset, M; Montet, Y; Guigliarelli, B; Forget, N; Asso, M; Bertrand, P; Fontecilla-Camps, J C; Hatchikian, E C

1998-09-29

The role of the high potential [3Fe-4S]1+,0 cluster of [NiFe] hydrogenase from Desulfovibrio species located halfway between the proximal and distal low potential [4Fe-4S]2+,1+ clusters has been investigated by using site-directed mutagenesis. Proline 238 of Desulfovibrio fructosovorans [NiFe] hydrogenase, which occupies the position of a potential ligand of the lacking fourth Fe-site of the [3Fe-4S] cluster, was replaced by a cysteine residue. The properties of the mutant enzyme were investigated in terms of enzymatic activity, EPR, and redox properties of the iron-sulfur centers and crystallographic structure. We have shown on the basis of both spectroscopic and x-ray crystallographic studies that the [3Fe-4S] cluster of D. fructosovorans hydrogenase was converted into a [4Fe-4S] center in the P238 mutant. The [3Fe-4S] to [4Fe-4S] cluster conversion resulted in a lowering of approximately 300 mV of the midpoint potential of the modified cluster, whereas no significant alteration of the spectroscopic and redox properties of the two native [4Fe-4S] clusters and the NiFe center occurred. The significant decrease of the midpoint potential of the intermediate Fe-S cluster had only a slight effect on the catalytic activity of the P238C mutant as compared with the wild-type enzyme. The implications of the results for the role of the high-potential [3Fe-4S] cluster in the intramolecular electron transfer pathway are discussed.

[3Fe-4S] to [4Fe-4S] cluster conversion in Desulfovibrio fructosovorans [NiFe] hydrogenase by site-directed mutagenesis

PubMed Central

Rousset, Marc; Montet, Yael; Guigliarelli, Bruno; Forget, Nicole; Asso, Marcel; Bertrand, Patrick; Fontecilla-Camps, Juan C.; Hatchikian, E. Claude

1998-01-01

The role of the high potential [3Fe-4S]1+,0 cluster of [NiFe] hydrogenase from Desulfovibrio species located halfway between the proximal and distal low potential [4Fe-4S]2+,1+ clusters has been investigated by using site-directed mutagenesis. Proline 238 of Desulfovibrio fructosovorans [NiFe] hydrogenase, which occupies the position of a potential ligand of the lacking fourth Fe-site of the [3Fe-4S] cluster, was replaced by a cysteine residue. The properties of the mutant enzyme were investigated in terms of enzymatic activity, EPR, and redox properties of the iron-sulfur centers and crystallographic structure. We have shown on the basis of both spectroscopic and x-ray crystallographic studies that the [3Fe-4S] cluster of D. fructosovorans hydrogenase was converted into a [4Fe-4S] center in the P238 mutant. The [3Fe-4S] to [4Fe-4S] cluster conversion resulted in a lowering of approximately 300 mV of the midpoint potential of the modified cluster, whereas no significant alteration of the spectroscopic and redox properties of the two native [4Fe-4S] clusters and the NiFe center occurred. The significant decrease of the midpoint potential of the intermediate Fe-S cluster had only a slight effect on the catalytic activity of the P238C mutant as compared with the wild-type enzyme. The implications of the results for the role of the high-potential [3Fe-4S] cluster in the intramolecular electron transfer pathway are discussed. PMID:9751716

Yesterday’s Doctors: The Human Aspects of Medical Education in Britain, 1957–93

PubMed Central

Bates, Victoria

2017-01-01

In the wake of the Second World War there was a movement to counterbalance the apparently increasingly technical nature of medical education. These reforms sought a more holistic model of care and to put people – rather than diseases – back at the centre of medical practice and medical education. This article shows that students often drove the early stages of education reform. Their innovations focused on relationships between doctors and their communities, and often took the form of informal discussions about medical ethics and the social dimensions of primary care. Medical schools began to pursue ‘humanistic’ education more formally from the 1980s onwards, particularly within the context of general practice curricula and with a focus on individual doctor–patient relationships. Overall from the 1950s to the 1990s there was a broad shift in discussions of the human aspects of medical education: from interest in patient communities to individuals; from social concerns to personal characteristics; and from the relatively abstract to the measurable and instrumental. There was no clear shift from ‘less’ to ‘more’ humanistic education, but rather a shift in the perceived goals of integrating human aspects of medical education. The human aspects of medicine show the importance of student activism in driving forward community and ethical medicine, and provide an important backdrop to the rise of competencies within general undergraduate education. PMID:27998331

Precision holography for N={2}^{\\ast } on S 4 from type IIB supergravity

NASA Astrophysics Data System (ADS)

Bobev, Nikolay; Gautason, Friðrik Freyr; van Muiden, Jesse

2018-04-01

We find a new supersymmetric solution of type IIB supergravity which is holographically dual to the planar limit of the four-dimensional N={2}^{\\ast } supersymmetric Yang-Mills theory on S 4. We study a probe fundamental string in this background which is dual to a supersymmetric Wilson loop in the N={2}^{\\ast } theory. Using holography we calculate the expectation value of this line operator to leading order in the 't Hooft coupling. The result is a non-trivial function of the mass parameter of the N={2}^{\\ast } theory that precisely matches the result from supersymmetric localization.

Electron excitation cross sections for the 2s(2)2p(3)4S(O) -- 2s(2)2p(3)2D(O) (forbidden) and 4S(O) -- 2s2p(4) 4P (resonance) transitions in O II

NASA Technical Reports Server (NTRS)

Zuo, M.; Smith, Steven J.; Chutjian, A.; Williams, I. D.; Tayal, S. S.; Mclaughlin, Brendan M.

1995-01-01

Experimental and theoretical excitation cross sections are reported for the first forbidden transition 4S(O) -- 2S(2)2p(3) 2D(O) (lambda-lambda 3726, 3729) and the first allowed (resonance) transition 4S(O) -- 2s2p(4) 4P(lambda-833) in O II. Use is made of electron energy loss and merged-beams methods. The electron energy range covered is 3.33 (threshold) to 15 eV for the S -- D transition, and 14.9 (threshold) to 40 eV for the S -- P transition. Care was taken to assess and minimize the metastable fraction of the O II beam. An electron mirror was designed and tested to reflect inelastically backscattered electrons into the forward direction to account for the full range of polar scattering angles. Comparisons are made between present experiments and 11-state R-matrix calculations. Calculations are also presented for the 4S(O) -- 2s(2)2p(3)2P(O) (lambda-2470) transition.

Fundamental movement skill performance of preschool children in relation to family context.

PubMed

Cools, Wouter; De Martelaer, Kristine; Samaey, Christiane; Andries, Caroline

2011-04-01

Evidence suggests the development of fundamental movement skill (FMS) is a key factor in promoting long-term physical activity. Low levels of activity among preschool children and the relationship between physical activity and the development of fundamental movement skills underline the need to determine the factors associated with children's development of such skills. As parents play an important role in the socialization process, the aim of this study was to examine correlates of family and neighbourhood characteristics as well as parental behaviour and beliefs on FMS performance in 4- to 6-year-old preschool children. Relationships between preschool children's FMS performance and family contextual variables were examined within a sample of 846 preschool children. Results identified positive associations of FMS performance with parental education, father's physical activity, transport to school by bicycle, and the high value placed by parents high on sport-specific aspects of children's physical activity. Variables negatively associated with preschool children's FMS performance included father-child interaction in TV-viewing and reading books, the high importance placed by parents on winning and performance in children's physical activity. Furthermore, the ambiguity of associations between FMS performance and parental beliefs underlined its complexity.

Rectenna session: Micro aspects

NASA Technical Reports Server (NTRS)

Gutmann, R. J.

1980-01-01

Two micro aspects of rectenna design are discussed: evaluation of the degradation in net rectenna RF to DC conversion efficiency due to power density variations across the rectenna (power combining analysis) and design of Yagi-Uda receiving elements to reduce rectenna cost by decreasing the number of conversion circuits (directional receiving elements). The first of these involves resolving a fundamental question of efficiency potential with a rectenna, while the second involves a design modification with a large potential cost saving.

Sensory v.s. Symbolic Aspects of Imagery Processes.

ERIC Educational Resources Information Center

Fleming, Malcolm L.

A central theoretical issue is that of the cognitive status of imagery. Detractors emphasize the merely-sensory aspects while proponents emphasize the also-symbolic aspects. Examined with reference to this issue are the theories of Piaget and Bruner, recent studies of concept learning and representation, and studies related to the Craik and…

Nuclei and Fundamental Symmetries

NASA Astrophysics Data System (ADS)

Haxton, Wick

2016-09-01

Nuclei provide marvelous laboratories for testing fundamental interactions, often enhancing weak processes through accidental degeneracies among states, and providing selection rules that can be exploited to isolate selected interactions. I will give an overview of current work, including the use of parity violation to probe unknown aspects of the hadronic weak interaction; nuclear electric dipole moment searches that may shed light on new sources of CP violation; and tests of lepton number violation made possible by the fact that many nuclei can only decay by rare second-order weak interactions. I will point to opportunities in both theory and experiment to advance the field. Based upon work supported in part by the US Department of Energy, Office of Science, Office of Nuclear Physics and SciDAC under Awards DE-SC00046548 (Berkeley), DE-AC02-05CH11231 (LBNL), and KB0301052 (LBNL).

Quantum information aspects of noncommutative quantum mechanics

NASA Astrophysics Data System (ADS)

Bertolami, Orfeu; Bernardini, Alex E.; Leal, Pedro

2018-01-01

Some fundamental aspects related with the construction of Robertson-Schrödinger-like uncertainty-principle inequalities are reported in order to provide an overall description of quantumness, separability and nonlocality of quantum systems in the noncommutative phase-space. Some consequences of the deformed noncommutative algebra are also considered in physical systems of interest.

Unification of Fundamental Forces

NASA Astrophysics Data System (ADS)

Salam, Abdus; Taylor, Foreword by John C.

2005-10-01

Foreword John C. Taylor; 1. Unification of fundamental forces Abdus Salam; 2. History unfolding: an introduction to the two 1968 lectures by W. Heisenberg and P. A. M. Dirac Abdus Salam; 3. Theory, criticism, and a philosophy Werner Heisenberg; 4. Methods in theoretical physics Paul Adrian Maurice Dirac.

Fundamental Travel Demand Model Example

NASA Technical Reports Server (NTRS)

Hanssen, Joel

2010-01-01

Instances of transportation models are abundant and detailed "how to" instruction is available in the form of transportation software help documentation. The purpose of this paper is to look at the fundamental inputs required to build a transportation model by developing an example passenger travel demand model. The example model reduces the scale to a manageable size for the purpose of illustrating the data collection and analysis required before the first step of the model begins. This aspect of the model development would not reasonably be discussed in software help documentation (it is assumed the model developer comes prepared). Recommendations are derived from the example passenger travel demand model to suggest future work regarding the data collection and analysis required for a freight travel demand model.

Calculation of the total electron excitation cross section in the Born approximation using Slater wave functions for the Li (2s yields 2p), Li (2s yields 3p), Na (3s yields 4p), Mg (3p yields 4s), Ca (4s yields 4p) and K (4s yields 4p) excitations. M.S. Thesis

NASA Technical Reports Server (NTRS)

Simsic, P. L.

1974-01-01

Excitation of neutral atoms by inelastic scattering of incident electrons in gaseous nebulae were investigated using Slater Wave functions to describe the initial and final states of the atom. Total cross sections using the Born Approximation are calculated for: Li(2s yields 2p), Na(3s yields 4p), k(4s yields 4p). The intensity of emitted radiation from gaseous nebulae is also calculated, and Maxwell distribution is employed to average the kinetic energy of electrons.

Was Fundamental Education Another Form Of Colonialism?

NASA Astrophysics Data System (ADS)

Watras, Joseph

2007-01-01

A description of the work of Pedro Tamesis Orata provides an opportunity to investigate the conflicts that can occur when educators seek to reduce poverty while trying to respect indigenous cultures. A native of the Philippines, Orata completed his doctoral studies at the Ohio State University in 1927. During US President Franklin Roosevelt's New Deal, he accepted the position of school principal for the US Bureau of Indian Affairs. After World War II, he directed the spread of fundamental education through the United Nations Educational, Scientific and Cultural Organization (UNESCO). In his final years, he returned to the Philippines where he began a movement to spread what were called self-help high schools. In these activities, Orata taught people to follow John Dewey's five steps of thinking while working to improve their standards of living. In the 1970s, educators, such as Paulo Freire, complained that problem-solving methods, similar to those Orata favored, reinforced the oppressive aspects of formerly colonial societies. While Freire may have been overly critical, conflicts among cultural orientations appear to be unavoidable. The hope behind this investigation is that the difficulties can be reduced when people understand the different forces that persist.

Self-organization: the fundament of cell biology.

PubMed

Wedlich-Söldner, Roland; Betz, Timo

2018-05-26

Self-organization refers to the emergence of an overall order in time and space of a given system that results from the collective interactions of its individual components. This concept has been widely recognized as a core principle in pattern formation for multi-component systems of the physical, chemical and biological world. It can be distinguished from self-assembly by the constant input of energy required to maintain order-and self-organization therefore typically occurs in non-equilibrium or dissipative systems. Cells, with their constant energy consumption and myriads of local interactions between distinct proteins, lipids, carbohydrates and nucleic acids, represent the perfect playground for self-organization. It therefore comes as no surprise that many properties and features of self-organized systems, such as spontaneous formation of patterns, nonlinear coupling of reactions, bi-stable switches, waves and oscillations, are found in all aspects of modern cell biology. Ultimately, self-organization lies at the heart of the robustness and adaptability found in cellular and organismal organization, and hence constitutes a fundamental basis for natural selection and evolution.This article is part of the theme issue 'Self-organization in cell biology'. © 2018 The Author(s).

Super reduced Fe4S4 cluster of Balch's dithiolene series.

PubMed

Begum, Ameerunisha; Moula, Golam; Bose, Moumita; Sarkar, Sabyasachi

2012-03-28

A super reduced Fe(4)S(4) cluster with a sulfur based radical, [NBu(4)](4)[Fe(3)(III)Fe(II)(μ(3)-S)(4)(mnt)(3)(6-)(mnt)(1-)˙](4-)˙, (1) (mnt, maleonitrile dithiolate) which evolves H(2)S gas on treatment with acid under ambient conditions has been synthesized and structurally characterized. The Fe-S distances in 1 are in the range 2.246-2.383 Å, in stark contrast to that of the known n = -2 member of the series based on the [Fe(4)(μ(3)-S)(4)(S(2)C(2)R(2))(4)](n) unit (R = CF(3), Ph) with Fe-S bond lengths of 2.149-2.186 Å. The EPR of 1 displays very weak signals at g, 4.03 and 2.38 along with a strong S-based radical EPR signal at g, 2.003 associated with five structured components tentatively assigned to hyperfine interaction arising out of the naturally abundant (57)Fe with = 88 G. The EPR profile resembles the reduced Fe-S cluster of CO inhibited Clostridium pasteurianum W5 hydrogenase or the Fe(4)S(4) centers of wild-type enzyme, IspH treated with HMBPP or IPP.

N4H9Cu7S4: a hydrazinium-based salt with a layered Cu7S4- framework.

PubMed

Mitzi, David B

2007-02-05

Crystals of a hydrazinium-based copper(I) sulfide salt, N4H9Cu7S4 (1), have been isolated by an ambient temperature solution-based process. In contrast to previously reported hydrazinium salts of main-group metal chalcogenides, which consist of isolated metal chalcogenide anions, and ACu7S4 (A = NH4+, Rb+, Tl+, K+), which contains a more three-dimensional Cu7S4- framework with partial Cu-site occupancy, the structure of 1 [P21, a = 6.8621(4) A, b = 7.9851(4) A, c = 10.0983(5) A, beta = 99.360(1) degrees , Z = 2] is composed of extended two-dimensional Cu7S4- slabs with full Cu-site occupancy. The Cu7S4- slabs are separated by a mixture of hydrazinium and hydrazine moieties. Thermal decomposition of 1 into copper(I) sulfide proceeds at a significantly lower temperature than that observed for analogous hydrazinium salts of previously considered metal chalcogenides, completing the transition at temperatures as low as 120 degrees C. Solutions of 1 may be used in the solution deposition of a range of Cu-containing chalcogenide films.

Tungsten phosphanylarylthiolato complexes [W{PhP(2-SC6H4)2-kappa3S,S',P} 2] and [W{P(2-SC6H4)3-kappa4S,S',S",P}2]: synthesis, structures and redox chemistry.

PubMed

Hildebrand, Alexandra; Lönnecke, Peter; Silaghi-Dumitrescu, Luminita; Hey-Hawkins, Evamarie

2008-09-14

PhP(2-SHC6H4)2 (PS2H2) reacts with WCl6 with reduction of tungsten to give the air-sensitive tungsten(IV) complex [W{PhP(2-SC6H4)2-kappa(3)S,S',P}2] (1). 1 is oxidised in air to [WO{PhPO(2-SC6H4)2-kappa(3)S,S',O}{PhP(2-SC6H4)2-kappa(3)S,S',P}] (2). The attempted synthesis of 2 by reaction of 1 with iodosobenzene as oxidising agent was unsuccessful. [W{P(2-SC6H4)3-kappa(4)S,S',S",P}2] (3) was formed in the reaction of P(2-SHC6H4)3 (PS3H3) with WCl6. The W(VI) complex 3 contains two PS3(3-) ligands, each coordinated in a tetradentate fashion resulting in a tungsten coordination number of eight. The reaction of 3 with AgBF4 yields the dinuclear tungsten complex [W2{P(2-SC6H4)3-kappa(4)S,S',S",P}3]BF4 (4). Complexes 1-4 were characterised by spectral methods and X-ray structure determination.

The polarization and the fundamental sensitivity of 39K (133Cs)-85Rb-4He hybrid optical pumping spin exchange relaxation free atomic magnetometers.

PubMed

Liu, Jian-Hua; Jing, Dong-Yang; Wang, Liang-Liang; Li, Yang; Quan, Wei; Fang, Jian-Cheng; Liu, Wu-Ming

2017-07-28

The hybrid optical pumping spin exchange relaxation free (SERF) atomic magnetometers can realize ultrahigh sensitivity measurement of magnetic field and inertia. We have studied the 85 Rb polarization of two types of hybrid optical pumping SERF magnetometers based on 39 K- 85 Rb- 4 He and 133 Cs- 85 Rb- 4 He respectively. Then we found that 85 Rb polarization varies with the number density of buffer gas 4 He and quench gas N 2 , pumping rate of pump beam and cell temperature respectively, which will provide an experimental guide for the design of the magnetometer. We obtain a general formula on the fundamental sensitivity of the hybrid optical pumping SERF magnetometer due to shot-noise. The formula describes that the fundamental sensitivity of the magnetometer varies with the number density of buffer gas and quench gas, the pumping rate of pump beam, external magnetic field, cell effective radius, measurement volume, cell temperature and measurement time. We obtain a highest fundamental sensitivity of 1.5073 aT/Hz 1/2 (1 aT = 10 -18 T) with 39 K- 85 Rb- 4 He magnetometer between above two types of magnetometers when 85 Rb polarization is 0.1116. We estimate the fundamental sensitivity limit of the hybrid optical pumping SERF magnetometer to be superior to 1.8359 × 10 -2 aT/Hz 1/2 , which is higher than the shot-noise-limited sensitivity of 1 aT/Hz 1/2 of K SERF atomic magnetometer.

Outstanding laser damage threshold in Li2MnGeS4 and tunable optical nonlinearity in diamond-like semiconductors.

PubMed

Brant, Jacilynn A; Clark, Daniel J; Kim, Yong Soo; Jang, Joon I; Weiland, Ashley; Aitken, Jennifer A

2015-03-16

The new Li2MnGeS4 and Li2CoSnS4 compounds result from employing a rational and simple design strategy that guides the discovery of diamond-like semiconductors (DLSs) with wide regions of optical transparency, high laser damage threshold, and efficient second-order optical nonlinearity. Single-crystal X-ray diffraction was used to solve and refine the crystal structures of Li2MnGeS4 and Li2CoSnS4, which crystallize in the noncentrosymmetric space groups Pna21 and Pn, respectively. Synchrotron X-ray powder diffraction (SXRPD) was used to assess the phase purity, and diffuse reflectance UV-vis-NIR spectroscopy was used to estimate the bandgaps of Li2MnGeS4 (Eg = 3.069(3) eV) and Li2CoSnS4 (Eg = 2.421(3) eV). In comparison with Li2FeGeS4, Li2FeSnS4, and Li2CoSnS4 DLSs, Li2MnGeS4 exhibits the widest region of optical transparency (0.60-25 μm) and phase matchability (≥1.6 μm). All four of the DLSs exhibit second-harmonic generation and are compared with the benchmark NLO material, AgGaSe2. Most remarkably, Li2MnGeS4 does not undergo two- or three-photon absorption upon exposure to a fundamental Nd:YAG beam (λ = 1.064 μm) and exhibits a laser damage threshold > 16 GW/cm(2).

Fundamental Quantum 1/F Noise in Ultrasmall Semiconductor Devices and Their Optimal Design Principles

DTIC Science & Technology

1988-05-31

Hooge parameter. 2. 1 / f Noise of the Recombination Current Generated in the Depletion Region The quantum i/ f ...theory. There are two forms of quantum 11f noise . In the first place C~ and Cn4 p n to quantum 1 / f noise theory. This would yield Hooge parameters S...Fundamental Quantum 1 / f Noise in Ultrasmall S~ iodcrD’vesadOtm.Dsgn P in. 12. PERSONAL AUTHOR(S) Handel, Peter H. (Princioal investiaat r) 13a. TYPE

The [4Fe-4S](2+) cluster in reconstituted biotin synthase binds S-adenosyl-L-methionine.

PubMed

Cosper, Michele Mader; Jameson, Guy N L; Davydov, Roman; Eidsness, Marly K; Hoffman, Brian M; Huynh, Boi Hanh; Johnson, Michael K

2002-11-27

The combination of resonance Raman, electron paramagnetic resonance and Mössbauer spectroscopies has been used to investigate the effect of S-adenosyl-l-methionine (SAM) on the spectroscopic properties of the [4Fe-4S]2+ cluster in biotin synthase. The results indicate that SAM interacts directly at a unique iron site of the [4Fe-4S]2+ cluster in BioB and support the hypothesis of a common inner-sphere mechanism for the reductive cleavage of SAM in the radical SAM family of Fe-S enzymes.

Brain temperature and its fundamental properties: a review for clinical neuroscientists

PubMed Central

Wang, Huan; Wang, Bonnie; Normoyle, Kieran P.; Jackson, Kevin; Spitler, Kevin; Sharrock, Matthew F.; Miller, Claire M.; Best, Catherine; Llano, Daniel; Du, Rose

2014-01-01

Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human diseases including: head trauma, stroke, multiple sclerosis, epilepsy, mood disorders, headaches, and neurodegenerative disorders, it is evident and well recognized that the therapeutic application of induced hypothermia is limited to a few highly selected clinical conditions such as cardiac arrest and hypoxic ischemic neonatal encephalopathy. Efforts to understand the fundamental aspects of brain temperature regulation are therefore critical for the development of safe, effective, and pragmatic clinical treatments for patients with brain injuries. Although centrally-mediated mechanisms to maintain a stable body temperature are relatively well established, very little is clinically known about brain temperature's spatial and temporal distribution, its physiological and pathological fluctuations, and the mechanism underlying brain thermal homeostasis. The human brain, a metabolically “expensive” organ with intense heat production, is sensitive to fluctuations in temperature with regards to its functional activity and energy efficiency. In this review, we discuss several critical aspects concerning the fundamental properties of brain temperature from a clinical perspective. PMID:25339859

Information physics fundamentals of nanophotonics.

PubMed

Naruse, Makoto; Tate, Naoya; Aono, Masashi; Ohtsu, Motoichi

2013-05-01

Nanophotonics has been extensively studied with the aim of unveiling and exploiting light-matter interactions that occur at a scale below the diffraction limit of light, and recent progress made in experimental technologies--both in nanomaterial fabrication and characterization--is driving further advancements in the field. From the viewpoint of information, on the other hand, novel architectures, design and analysis principles, and even novel computing paradigms should be considered so that we can fully benefit from the potential of nanophotonics. This paper examines the information physics aspects of nanophotonics. More specifically, we present some fundamental and emergent information properties that stem from optical excitation transfer mediated by optical near-field interactions and the hierarchical properties inherent in optical near-fields. We theoretically and experimentally investigate aspects such as unidirectional signal transfer, energy efficiency and networking effects, among others, and we present their basic theoretical formalisms and describe demonstrations of practical applications. A stochastic analysis of light-assisted material formation is also presented, where an information-based approach provides a deeper understanding of the phenomena involved, such as self-organization. Furthermore, the spatio-temporal dynamics of optical excitation transfer and its inherent stochastic attributes are utilized for solution searching, paving the way to a novel computing paradigm that exploits coherent and dissipative processes in nanophotonics.

Monothiol Glutaredoxins Can Bind Linear [Fe3S4]+ and [Fe4S4]2+ Clusters in Addition to [Fe2S2]2+ Clusters: Spectroscopic Characterization and Functional Implications

PubMed Central

Zhang, Bo; Bandyopadhyay, Sibali; Shakamuri, Priyanka; Naik, Sunil G.; Huynh, Boi Hanh; Couturier, Jérémy; Rouhier, Nicolas; Johnson, Michael K.

2013-01-01

Saccharomyces cerevisiae mitochondrial glutaredoxin 5 (Grx5) is the archetypical member of a ubiquitous class of monothiol glutaredoxins with a strictly conserved CGFS active-site sequence that has been shown to function in biological [Fe2S2]2+ cluster trafficking. In this work, we show that recombinant S. cerevisiae Grx5 purified aerobically after prolonged exposure of the cell-free extract to air or after anaerobic reconstitution in the presence of glutathione, predominantly contains a linear [Fe3S4]+ cluster. The excited state electronic properties and ground state electronic and vibrational properties of the linear [Fe3S4]+ cluster have been characterized using UV-visible absorption/CD/MCD, EPR, Mössbauer and resonance Raman spectroscopies. The results reveal a rhombic S = 5/2 linear [Fe3S4]+ cluster with properties similar to those reported for synthetic linear [Fe3S4]+ clusters and the linear [Fe3S4]+ clusters in purple aconitase. Moreover, the results indicate that the Fe-S cluster content previously reported for many monothiol Grxs has been misinterpreted exclusively in terms of [Fe2S2]2+ clusters, rather than linear [Fe3S4]+ clusters or mixtures of linear [Fe3S4]+ and [Fe2S2]2+ clusters. In the absence of GSH, anaerobic reconstitution of Grx5 yields a dimeric form containing one [Fe4S4]2+ cluster that competent for in vitro activation of apo-aconitase, via intact cluster transfer. The ligation of the linear [Fe3S4]+ and [Fe4S4]2+ clusters in Grx5 has been assessed by spectroscopic, mutational and analytical studies. Potential roles for monothiol Grx5 in scavenging and recycling linear [Fe3S4]+ clusters released during protein unfolding under oxidative stress conditions and in maturation of [Fe4S4]2+ cluster-containing proteins are discussed in light of these results. PMID:24032439

Aspects of science engagement, student background, and school characteristics: Impacts on science achievement of U.S. students

NASA Astrophysics Data System (ADS)

Grabau, Larry J.

Science achievement of U.S. students has lagged significantly behind other nations; educational reformers have suggested science engagement may enhance this critical measure. The 2006 Program for International Student Assessment (PISA) was science-focused and measured science achievement along with nine aspects of science engagement: science self-efficacy, science self-concept, enjoyment of science, general interest in learning science, instrumental motivation for science, future-oriented science motivation, general value of science, personal value of science, and science-related activities. I used multilevel modeling techniques to address both aspects of science engagement and science achievement as outcome variables in the context of student background and school characteristics. Treating aspects of science engagement as outcome variables provided tests for approaches for their enhancement; meanwhile, treating science achievement as the outcome variable provided tests for the influence of the aspects of science engagement on science achievement under appropriate controls. When aspects of science engagement were treated as outcome variables, gender and father's SES had frequent (significant) influences, as did science teaching strategies which focused on applications or models and hands-on activities over-and-above influences of student background and other school characteristics. When science achievement was treated as the outcome variable, each aspect of science engagement was significant, and eight had medium or large effect sizes (future-oriented science motivation was the exception). The science teaching strategy which involved hands-on activities frequently enhanced science achievement over-and-above influences of student background and other school characteristics. Policy recommendations for U.S. science educators included enhancing eight aspects of science engagement and implementing two specific science teaching strategies (focus on applications or models

Four new chalcohalides, NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br and CsBa{sub 2}SnS{sub 4}Cl: Syntheses, crystal structures and optical properties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Chao; Feng, Kai; Tu, Heng

Four new chalcohalides, namely NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br, and CsBa{sub 2}SnS{sub 4}Cl, have been synthesized by the conventional high temperature solid-state reactions. They crystallize in three different space groups: space group I4/mcm for NaBa{sub 2}SnS{sub 4}Cl and KBa{sub 2}SnS{sub 4}Cl, Pnma for KBa{sub 2}SnS{sub 4}Br, and P2{sub 1}/c for CsBa{sub 2}SnS{sub 4}Cl. In all four compounds, the X{sup −} halide anions are only connected to six alkali metal or Ba cations, and the Sn atoms are only tetrahedrally enjoined to four S atoms. However, the M–X–Ba pseudo layers and the SnS{sub 4} tetrahedra are arrangedmore » in different ways in the three structural types, which demonstrates the interesting effect of ionic radii on the crystal structures. UV–vis–NIR spectroscopy measurements indicate that NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br, and CsBa{sub 2}SnS{sub 4}Cl have band gaps of 2.28, 2.30, 1.95, and 2.06 eV, respectively. - Graphical abstract: A new series of chalcohalides, NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br and CsBa{sub 2}SnS{sub 4}Cl have been obtained. They present three different space groups: NaBa{sub 2}SnS{sub 4}Cl and KBa{sub 2}SnS{sub 4}Cl in space group I4/mcm, KBa{sub 2}SnS{sub 4}Br in Pnma and CsBa{sub 2}SnS{sub 4}Cl in space group P2{sub 1}/c. UV–vis–NIR spectroscopy measurements indicate that NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br and CsBa{sub 2}SnS{sub 4}Cl have band gaps of 2.28, 2.30 1.95, and 2.06 eV, respectively. - Highlights: • Four new chalcohalides, NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br and CsBa{sub 2}SnS{sub 4}Cl were obtained. • They adopt three different structures owing to different ionic radii and elemental electronegativity. • NaBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Cl, KBa{sub 2}SnS{sub 4}Br and CsBa{sub 2}SnS{sub 4}Cl have

Behavioural aspects of terrorism.

PubMed

Leistedt, Samuel J

2013-05-10

Behavioural and social sciences are useful in collecting and analysing intelligence data, understanding terrorism, and developing strategies to combat terrorism. This article aims to examine the psychopathological concepts of terrorism and discusses the developing roles for behavioural scientists. A systematic review was conducted of studies investigating behavioural aspects of terrorism. These studies were identified by a systematic search of databases, textbooks, and a supplementary manual search of references. Several fundamental concepts were identified that continue to influence the motives and the majority of the behaviours of those who support or engage in this kind of specific violence. Regardless of the psychological aspects and new roles for psychiatrists, the behavioural sciences will continue to be called upon to assist in developing better methods to gather and analyse intelligence, to understand terrorism, and perhaps to stem the radicalisation process. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Electronic structure and fragmentation properties of [Fe4S4(SEt)4-x(SSEt)x]2-

NASA Astrophysics Data System (ADS)

Fu, You-Jun; Laskin, Julia; Wang, Lai-Sheng

2007-06-01

A limited exposure of (n-Bu4N)2[Fe4S4(SEt)4] solutions in acetonitrile to air was found to produce a new series of [4Fe-4S] cluster complexes, [Fe4S4(SEt)4-x(SSEt)x]2- (x = 1-4), with the original -SEt ligands substituted by -SSEt di-sulfide ligands, which were formed due to partial decomposition of the [4Fe-4S] core in parent [Fe4S4(SEt)4]2-. The products were first observed in the experiments with an ESI-ion Trap-TOF mass spectrometer and were further identified using high resolution Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. Photoelectron spectra of the [Fe4S4(SEt)4-x(SSEt)x]2- dianions revealed that the -SSEt coordination induced little change in the electronic structure of the [4Fe-4S] cluster, but the electron binding energies of [Fe4S4(SEt)4-x(SSEt)x]2- increased from 0.52 to 0.73 eV with increase in x from 0 to 4, suggesting a greater electron withdrawing ability of -SSEt than -SEt. In high resolution MS/MS experiments on [Fe4S4(SEt)3(SSEt)]2-/1-, clusters with both charge states yielded fragment [Fe4S4(SEt)3]-, suggesting that -SSEt could be lost either as a negatively charged ion SSEt- from the doubly charged precursor, or as a radical SSEt from the singly charged species. The biological implication of the interaction between [Fe4S4(SEt)4]2- and O2 is discussed in comparison to the air exposure of [4Fe-4S] proteins to the air.

A fundamental mode Nd:GdVO4 laser pumped by a large aperture 808 nm VCSEL

NASA Astrophysics Data System (ADS)

Hao, Y. Q.; Ma, J. L.; Yan, C. L.; Liu, G. J.; Ma, X. H.; Gong, J. F.; Feng, Y.; Wei, Z. P.; Wang, Y. X.; Zhao, Y. J.

2013-05-01

A fundamental mode Nd:GdVO4 laser pumped by a vertical cavity surface emitting laser (VCSEL) is experimentally demonstrated. The VCSEL has a circular output-beam which makes it easier for it to be directly coupled to a Nd:GdVO4 microcrystal. In our research, a large aperture 808 nm VCSEL, with a multi-ring-shaped aperture (MRSA) and an almost Gaussian-shaped far-field profile, is used as the pumping source. Experimental results for the Nd:GdVO4 laser pumped by the VCSEL are presented. The maximum output peak power of 0.754 W is obtained under a pump peak power of 1.3 W, and the corresponding opto-optic conversion efficiency is 58.1%. The average slope efficiency is 65.8% from the threshold pump power of 0.2 W to the pump power of 1.3 W. The laser beam quality factors are measured to be {M}x2=1.2 0 and {M}y2=1.1 5.

Criticism of generally accepted fundamentals and methodologies of traffic and transportation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerner, Boris S.

It is explained why the set of the fundamental empirical features of traffic breakdown (a transition from free flow to congested traffic) should be the empirical basis for any traffic and transportation theory that can be reliable used for control and optimization in traffic networks. It is shown that generally accepted fundamentals and methodologies of traffic and transportation theory are not consistent with the set of the fundamental empirical features of traffic breakdown at a highway bottleneck. To these fundamentals and methodologies of traffic and transportation theory belong (i) Lighthill-Whitham-Richards (LWR) theory, (ii) the General Motors (GM) model class (formore » example, Herman, Gazis et al. GM model, Gipps’s model, Payne’s model, Newell’s optimal velocity (OV) model, Wiedemann’s model, Bando et al. OV model, Treiber’s IDM, Krauß’s model), (iii) the understanding of highway capacity as a particular stochastic value, and (iv) principles for traffic and transportation network optimization and control (for example, Wardrop’s user equilibrium (UE) and system optimum (SO) principles). Alternatively to these generally accepted fundamentals and methodologies of traffic and transportation theory, we discuss three-phase traffic theory as the basis for traffic flow modeling as well as briefly consider the network breakdown minimization (BM) principle for the optimization of traffic and transportation networks with road bottlenecks.« less

1.4 GHz on the Fundamental Plane of black hole activity

NASA Astrophysics Data System (ADS)

Saikia, Payaswini; Körding, Elmar; Dibi, Salome

2018-06-01

The Fundamental Plane (FP) of black hole activity is an empirical relationship between the O III/X-ray luminosity depicting the accretion power, the radio luminosity as a probe of the instantaneous jet power and the mass of the black hole. For the first time, we use the 1.4 GHz FIRST radio luminosities on the optical FP, to investigate whether or not Faint Images of the Radio Sky at Twenty-Centimetres (FIRST) fluxes can trace nuclear activity. We use an SDSS-FIRST cross-correlated sample of 10 149 active galaxies and analyse their positioning on the optical FP. We focus on various reasons that can cause the discrepancy between the observed FIRST radio fluxes and the theoretically expected core radio fluxes, and show that FIRST fluxes are heavily contaminated by non-nuclear, extended components and other environmental factors. We show that the subsample of `compact sources', which should have negligible lobe contribution, statistically follow the FP when corrected for relativistic beaming, while all the other sources lie above the plane. The sample of low-ionization nuclear emission-line regions (LINERs), which should have negligible lobe and beaming contribution, also follow the FP. A combined fit of the low-luminosity AGN and the X-ray binaries, with the LINERs, results in the relation log LR = 0.77 log L_{O III} + 0.69 log M. Assuming that the original FP relation is correct, we conclude that 1.4 GHz FIRST fluxes do not trace the pure `core' jet and instantaneous nuclear activity in the AGN, and one needs to be careful while using it on the FP of black hole activity.

8 CFR 236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants. 236.4 Section 236.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS... of Aliens Prior to Order of Removal § 236.4 Removal of S-5, S-6, and S-7 nonimmigrants. (a) Condition...

Copy Number Variation Is a Fundamental Aspect of the Placental Genome

PubMed Central

Hannibal, Roberta L.; Chuong, Edward B.; Rivera-Mulia, Juan Carlos; Gilbert, David M.; Valouev, Anton; Baker, Julie C.

2014-01-01

Discovery of lineage-specific somatic copy number variation (CNV) in mammals has led to debate over whether CNVs are mutations that propagate disease or whether they are a normal, and even essential, aspect of cell biology. We show that 1,000N polyploid trophoblast giant cells (TGCs) of the mouse placenta contain 47 regions, totaling 138 Megabases, where genomic copies are underrepresented (UR). UR domains originate from a subset of late-replicating heterochromatic regions containing gene deserts and genes involved in cell adhesion and neurogenesis. While lineage-specific CNVs have been identified in mammalian cells, classically in the immune system where V(D)J recombination occurs, we demonstrate that CNVs form during gestation in the placenta by an underreplication mechanism, not by recombination nor deletion. Our results reveal that large scale CNVs are a normal feature of the mammalian placental genome, which are regulated systematically during embryogenesis and are propagated by a mechanism of underreplication. PMID:24785991

Copy number variation is a fundamental aspect of the placental genome.

PubMed

Hannibal, Roberta L; Chuong, Edward B; Rivera-Mulia, Juan Carlos; Gilbert, David M; Valouev, Anton; Baker, Julie C

2014-05-01

Discovery of lineage-specific somatic copy number variation (CNV) in mammals has led to debate over whether CNVs are mutations that propagate disease or whether they are a normal, and even essential, aspect of cell biology. We show that 1,000 N polyploid trophoblast giant cells (TGCs) of the mouse placenta contain 47 regions, totaling 138 Megabases, where genomic copies are underrepresented (UR). UR domains originate from a subset of late-replicating heterochromatic regions containing gene deserts and genes involved in cell adhesion and neurogenesis. While lineage-specific CNVs have been identified in mammalian cells, classically in the immune system where V(D)J recombination occurs, we demonstrate that CNVs form during gestation in the placenta by an underreplication mechanism, not by recombination nor deletion. Our results reveal that large scale CNVs are a normal feature of the mammalian placental genome, which are regulated systematically during embryogenesis and are propagated by a mechanism of underreplication.

Jet-cooled infrared absorption spectrum of the v4 fundamental band of HCOOH and HCOOD

NASA Astrophysics Data System (ADS)

Luo, Wei; Zhang, Yulan; Li, Wenguang; Duan, Chuanxi

2017-04-01

The jet-cooled absorption spectrum of the v4 fundamental band of normal formic acid (HCOOH) and deuterated formic acid (HCOOD) was recorded in the frequency range of 1370-1392 cm-1 with distributed-feedback quantum cascade lasers (DFB-QCLs) as the tunable infrared radiations. A segmented rapid-scan data acquisition scheme was developed for pulsed supersonic jet infrared laser absorption spectroscopy based on DFB-QCLs with a moderate vacuum pumping capacity. The unperturbed band-origin and rotational constants in the excited vibrational state were determined for both HCOOH and HCOOD. The unperturbed band-origin locates at 1379.05447(11) cm-1 for HCOOH, and 1366.48430(39) cm-1 for HCOOD, respectively.

Absolute structure and structure-function relationships of 4R,2‧R and 4S,2‧S Pidotimod®

NASA Astrophysics Data System (ADS)

Sarno, Simone; Manzo, Angelo M.; Ferraris, Davide M.; Miggiano, Riccardo; Rizzi, Menico; Palin, Luca; Boccaleri, Enrico; Milanesio, Marco

2017-11-01

Pidotimod® is a dipeptide with widely recognized immunomodulatory properties and with particularly beneficial effects for the treatment of acute respiratory and urinary tract infections. Pidotimod® presents two chiral centres which originate four stereoisomers. (4R,2‧S, 4S,2‧R, 4R,2‧R and 4S,2‧S). To date, only the 4R,2‧S and 4S,2‧R stereoisomers are reported in the literature. We report here the absolute crystal structure of the 4R,2‧R and 4S,2‧S diastereoisomers of Pidotimod®, obtained by crystals grown by slow evaporation of a mixture of water and ethanol. The analysis of the crystal structures revealed the key role of a solvent water molecule in the crystal packing engaged in an extended hydrogen bonds network. This water-assisted H-bond network explained the recalcitrance of 4R,2‧R and 4S,2‧S Pidotimod® to crystallize in pure ethanol, despite their high solubility, and the growth of well-diffracting crystals only in presence of water. Hence, Pidotimod®4R,2‧R and 4S,2‧S stereoisomers markedly differ from the 4R,2‧S and 4S,2‧R ones, which crystallize in absence of water. The molecular and crystal structures of the 4R,2‧R and 4S,2‧S Pidotimod® stereoisomers here presented gave some hints on the differences in bioactivity with respect to the 4R,2‧S stereoisomer. In fact, beyond an expected different dispositions of hydrophilic ligands, 4R,2‧R and 4S,2‧S showed an incremented tendency to intermolecular H-bonds with water.

8 CFR 1236.4 - Removal of S-5, S-6, and S-7 nonimmigrants.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Removal of S-5, S-6, and S-7 nonimmigrants. 1236.4 Section 1236.4 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF... OF ALIENS ORDERED REMOVED Detention of Aliens Prior to Order of Removal § 1236.4 Removal of S-5, S-6...

Combustion Fundamentals Research

NASA Technical Reports Server (NTRS)

1983-01-01

Increased emphasis is placed on fundamental and generic research at Lewis Research Center with less systems development efforts. This is especially true in combustion research, where the study of combustion fundamentals has grown significantly in order to better address the perceived long term technical needs of the aerospace industry. The main thrusts for this combustion fundamentals program area are as follows: analytical models of combustion processes, model verification experiments, fundamental combustion experiments, and advanced numeric techniques.

Structure and electrochemistry of proteins harboring iron-sulfur clusters of different nuclearities. Part II. [4Fe-4S] and [3Fe-4S] iron-sulfur proteins.

PubMed

Zanello, Piero

2018-06-01

In the context of the plethora of proteins harboring iron-sulfur clusters we have already reviewed structure/electrochemistry of metalloproteins expressing single types of iron-sulfur clusters (namely: {Fe(Cys) 4 }, {[Fe 2 S 2 ](Cys) 4 }, {[Fe 2 S 2 ](Cys) 3 (X)} (X = Asp, Arg, His), {[Fe 2 S 2 ](Cys) 2 (His) 2 }, {[Fe 3 S 4 ](Cys) 3 }, {[Fe 4 S 4 ](Cys) 4 } and {[Fe 4 S 4 ](S γ Cys ) 3 (nonthiolate ligand)} cores) and their synthetic analogs. More recently we are focussing on structure/electrochemistry of metalloproteins harboring iron-sulfur centres of different nuclearities. Having started such a subject with proteins harboring [4Fe-4S] and [2Fe-2S] clusters, we now depict the state of art of proteins containing [4Fe-4S] and [3Fe-4S] clusters. Copyright © 2018 Elsevier Inc. All rights reserved.

Phase diagrams of the sections As/sub 2/S/sub 3/-Tl/sub 3/AsS/sub 4/, Tl/sub 3/AsS/sub 4/-S, and Tl/sub 3/AsS/sub 4/-Tl/sub 2/S of the ternary system As-Tl-S

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vorob'ev, Yu.I.; Velikova, N.G.; Kirilenko, V.V.

1987-12-01

Using DTA and XPA methods, microstructural investigations, and microhardness measurements, phase diagrams of the quasibinary sections As/sub 2/S/sub 3/-Tl/sub 3/AsS/sub 4/, Tl/sub 3/AsS/sub 4/-S, and Tl/sub 3/AsS/sub 4/-Tl/sub 2/S, are characterized by five ternary compounds Tl/sub 3/As/sub 5/S/sub 10/, Tl/sub 9/As/sub 5/S/sub 15/, Tl/sub 9/As/sub 3/S/sub 13/, Tl/sub 3/AsS/sub 6/, and Tl/sub 8/As/sub 2/S/sub 9/, which decompose by peritectic reactions at 198, 307, 408, 362, and 318/degree/C, respectively. Interplanar spacings and line intensities are given for the detected compounds. Glass formation is considered in the Tl-As-S system.

Improved GaSb surfaces using a (NH4)2S/(NH4)2S04 solution

NASA Astrophysics Data System (ADS)

Murape, D. M.; Eassa, N.; Nyamhere, C.; Neethling, J. H.; Betz, R.; Coetsee, E.; Swart, H. C.; Botha, J. R.; Venter, A.

2012-05-01

Bulk (1 0 0) n-GaSb surfaces have been treated with a sulphur based solution ((NH4)2S/(NH4)2SO4) to which sulphur has been added, not previously reported for the passivation of GaSb surfaces. Au/n-GaSb Schottky barrier diodes (SBDs) fabricated on the treated material show significant improvement compared to that of the similar SBDs on the as-received material as evidenced by the lower ideality factor (n), higher barrier height (ϕb) and lower contact resistance obtained. Additionally, the reverse leakage current, although not saturating, has been reduced by almost an order of magnitude at -0.2 V. The sample surfaces were studied by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The native oxide, Sb-O, present on the as-received material is effectively removed on treating with ([(NH4)2S/(NH4)2SO4]+S) and (NH4)2S. Analysis of the as-received surface by XPS, prior to and after argon sputtering, suggests that the native oxide layer is ≤8.5 nm.

ASPECT

EPA Pesticide Factsheets

Able to deploy within one hour of notification, EPA's Airborne Spectral Photometric Environmental Collection Technology (ASPECT) is the nation’s only airborne real-time chemical and radiological detection, infrared and photographic imagery platform.

Arguments for fundamental emission by the parametric process L yields T + S in interplanetary type III bursts. [langmuir, electromagnetic, ion acoustic waves (L, T, S)

NASA Technical Reports Server (NTRS)

Cairns, I. H.

1984-01-01

Observations of low frequency ion acoustic-like waves associated with Langmuir waves present during interplanetary Type 3 bursts are used to study plasma emission mechanisms and wave processes involving ion acoustic waves. It is shown that the observed wave frequency characteristics are consistent with the processes L yields T + S (where L = Langmuir waves, T = electromagnetic waves, S = ion acoustic waves) and L yields L' + S proceeding. The usual incoherent (random phase) version of the process L yields T + S cannot explain the observed wave production time scale. The clumpy nature of the observed Langmuir waves is vital to the theory of IP Type 3 bursts. The incoherent process L yields T + S may encounter difficulties explaining the observed Type 3 brightness temperatures when Langmuir wave clumps are incorporated into the theory. The parametric process L yields T + S may be the important emission process for the fundamental radiation of interplanetary Type 3 bursts.

Resident Research Fundamentals Course Human Research Curves in the Road

DTIC Science & Technology

2017-09-27

34’! r o ¥ ~{,,.,,•’" ----------------------- Warrior Medics - Mission Ready- Patient Focused 4 3. Research using multi-site administered surveys 4...MDW/SGVU SUBJECT: Professional Presentation Approval 27 JULY 2017 Your paper, entitled Resident Research Fundamentals Course - "Human Research ...Curves in the Road" (27 Sep 2017) presented at/published to Resident Research Fundamentals Course - JBSA Lackland, San Antonio, TX - 27 Sep 2017 in

FUNdamental Movement in Early Childhood.

ERIC Educational Resources Information Center

Campbell, Linley

2001-01-01

Noting that the development of fundamental movement skills is basic to children's motor development, this booklet provides a guide for early childhood educators in planning movement experiences for children between 4 and 8 years. The booklet introduces a wide variety of appropriate practices to promote movement skill acquisition and increased…

Bulk superconductivity in bismuth oxysulfide Bi4O4S3.

PubMed

Singh, Shiva Kumar; Kumar, Anuj; Gahtori, Bhasker; Shruti; Sharma, Gyaneshwar; Patnaik, Satyabrata; Awana, Veer P S

2012-10-10

A very recent report on the observation of superconductivity in Bi(4)O(4)S(3) [Mizuguchi, Y.; http://arxiv.org/abs/1207.3145] could potentially reignite the search for superconductivity in a broad range of layered sulfides. We report here the synthesis of Bi(4)O(4)S(3) at 500 °C by a vacuum encapsulation technique and its basic characterizations. The as-synthesized Bi(4)O(4)S(3) was contaminated with small amounts of Bi(2)S(3) and Bi impurities. The majority phase was found to be tetragonal (space group I4/mmm) with lattice parameters a = 3.9697(2) Å and c = 41.3520(1) Å. Both AC and DC magnetization measurements confirmed that Bi(4)O(4)S(3) is a bulk superconductor with a superconducting transition temperature (T(c)) of 4.4 K. Isothermal magnetization (M-H) measurements indicated closed loops with clear signatures of flux pinning and irreversible behavior. The lower critical field (H(c1)) at 2 K for the new superconductor was found to be ~15 Oe. Magnetotransport measurements showed a broadening of the resistivity (ρ) and a decrease in T(c) (ρ = 0) with increasing magnetic field. The extrapolated upper critical field H(c2)(0) was ~31 kOe with a corresponding Ginzburg-Landau coherence length of ~100 Å . In the normal state, the ρ ~ T(2) dependence was not indicated. Hall resistivity data showed a nonlinear magnetic field dependence. Our magnetization and electrical transport measurements substantiate the appearance of bulk superconductivity in as-synthesized Bi(4)O(4)S(3). On the other hand, Bi heat-treated at the same temperature is not superconducting, thus excluding the possibility of impurity-driven superconductivity in the newly discovered superconductor Bi(4)O(4)S(3).

Investigation of magnetic properties on spin-ordering effects of FeGa2S4 and FeIn2S4

NASA Astrophysics Data System (ADS)

Myoung, Bo Ra; Lim, Jung Tae; Kim, Chul Sung

2017-09-01

We have studied crystal and magnetic properties of chalcogenides FeGa2S4 and FeIn2S4 with X-ray diffractometer (XRD), magnetic property measurement system (MPMS), magnetometer, physical property measurement system (PPMS), and Mössbauer spectrometer. The crystal structure has 2-dimension triangular lattice structure with P-3m1 of FeGa2S4, while FeIn2S4 has inverse spinel with space group Fd3m. The AC magnetic susceptibility measurements show that FeGa2S4 is an insulating spin glass material, exhibiting geometrical frustration, unlike in the antiferromagnetic [AFM] metallic spin glass FeIn2S4. From hysteresis (M-H) curves at 4.2 K, FeGa2S4 has spin-flop behavior with an angle of 120° of triangle, as against linear slope of FeIn2S4 due to anti-parallel spin. The gap energy by splitting of 5T2g, Δ1 and electric quadrupole splitting ΔEQ of FeIn2S4 are much higher than that of FeGa2S4 at 4.2 K because FeGa2S4 is geometrically frustrated magnet having degenerate ground state at low temperature.

Inversion of high frequency surface waves with fundamental and higher modes

USGS Publications Warehouse

Xia, J.; Miller, R.D.; Park, C.B.; Tian, G.

2003-01-01

The phase velocity of Rayleigh-waves of a layered earth model is a function of frequency and four groups of earth parameters: compressional (P)-wave velocity, shear (S)-wave velocity, density, and thickness of layers. For the fundamental mode of Rayleigh waves, analysis of the Jacobian matrix for high frequencies (2-40 Hz) provides a measure of dispersion curve sensitivity to earth model parameters. S-wave velocities are the dominant influence of the four earth model parameters. This thesis is true for higher modes of high frequency Rayleigh waves as well. Our numerical modeling by analysis of the Jacobian matrix supports at least two quite exciting higher mode properties. First, for fundamental and higher mode Rayleigh wave data with the same wavelength, higher modes can "see" deeper than the fundamental mode. Second, higher mode data can increase the resolution of the inverted S-wave velocities. Real world examples show that the inversion process can be stabilized and resolution of the S-wave velocity model can be improved when simultaneously inverting the fundamental and higher mode data. ?? 2002 Elsevier Science B.V. All rights reserved.

Joint inversion of fundamental and higher mode Rayleigh waves

USGS Publications Warehouse

Luo, Y.-H.; Xia, J.-H.; Liu, J.-P.; Liu, Q.-S.

2008-01-01

In this paper, we analyze the characteristics of the phase velocity of fundamental and higher mode Rayleigh waves in a six-layer earth model. The results show that fundamental mode is more sensitive to the shear velocities of shallow layers (< 7 m) and concentrated in a very narrow band (around 18 Hz) while higher modes are more sensitive to the parameters of relatively deeper layers and distributed over a wider frequency band. These properties provide a foundation of using a multi-mode joint inversion to define S-wave velocity. Inversion results of both synthetic data and a real-world example demonstrate that joint inversion with the damped least squares method and the SVD (Singular Value Decomposition) technique to invert Rayleigh waves of fundamental and higher modes can effectively reduce the ambiguity and improve the accuracy of inverted S-wave velocities.

Fundamental absorption edge of NiO nanocrystals

NASA Astrophysics Data System (ADS)

Sokolov, V. I.; Druzhinin, A. V.; Kim, G. A.; Gruzdev, N. B.; Yermakov, A. Ye.; Uimin, M. A.; Byzov, I. V.; Shchegoleva, N. N.; Vykhodets, V. B.; Kurennykh, T. E.

2013-12-01

NiO nanocrystals with the average size of 5, 10 and 25 nm were synthesized by gas-condensation method. The well-defined increase of the optical density D near the fundamental absorption edge of NiO nanocrystals in the range of 3.5-4.0 eV observed after the annealing in air is caused by the oxygen content growth. It is the direct experimental evidence of the fact that p-d charge transfer transitions form the fundamental absorption edge.

Synthesis, Structure, and Characterization of Cu4S10(4-methylpyridine)4

NASA Technical Reports Server (NTRS)

Hepp, Aloysius F.; Richman, Robert M.; Duraj, Stan A.; Andras, Maria T.; Moore, Hall L.; Sabat, Michal; Eckles, William E.; Martuch, Robert A.

1996-01-01

The title compound, Cu4S10(4-methylpyridine)(sub 4) (dot) 4-methylpyridine was prepared by three different reactions: the oxidation of copper powder by sulfur and the reaction of copper (I) sulfide (or CuBr (dot) SMe2) with excess sulfur, both in the coordinating solvent, 4-methylpyridine. Red crystals of the compound obtained by layering with hexanes were subjected to single crystal X-ray diffraction. The structure was refined to R = 0.026 and R(sub w) = 0.036 in a space group P1bar (No. 2), with Z = 2, a = 13.983 (2) A, b = 15.384 (2) A, c = 9.660 (1) A, alpha = 93.87 (1)deg., beta = 93.38 (1)deg., gamma = 99.78 (1)deg., V = 2037.9 (9) A(exp 3). The compound has approximate S(sub 4) symmetry and consists of two pentasulfide chains linking four Cu(I) ions, each with a corrdinating 2-methylpyridine. The infrared spectrum was dominated by absorption due to coordinated 4-methylpyridine with several low-energy peaks attributable to S-S stretches, which were also observed by Raman spectroscopy. A featureless electronic absorption spectrum yielded a single peak in the near ultraviolet upon computer enhancement (lambda = 334 nm, epsilon = 10,000), most likely an intraligand transition. Cyclic voltammetry indicates that the polysulfide complex undergoes irrversible oxidation and reduction at +0.04 and -0.34 V vs. SCE, respectively, at 298 K in 4-methylpyridine when swept at 20 mV/sec. The electrochemical behavior was unvaried even at sweep rates as high as 100 V/sec.

Evaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum.

PubMed

Szymanski, Pawel T; Ahmed, Safwat A; Radwan, Mohamed M; Khalifa, Sherief I; Fahmy, Hesham

2014-08-01

Three natural cembranoids from the Red Sea soft coral Sarcophyton glaucum namely (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol were evaluated for their inhibitory effects on mouse melanoma B16F10 cell growth. Results show that all the cembranoids strongly inhibit viability of melanoma cells particularly during 48 -72 hrs treatment and also inhibit de novo DNA synthesis and PARP activity and stimulate fragmentation of DNA. (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol was not cytotoxic to monkey kidney CV-1 cells at the concentration that produces the anti-melanoma effects which indicates that this compound may be a good candidate for further development. (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol were found to be cytotoxic to healthy cells.

Gas Hydrates as a CH4 Source and a CO2 Sink: New Approaches Based on Fundamental Research

NASA Astrophysics Data System (ADS)

Schicks, J. M.; Spangenberg, E.; Erzinger, J.

2007-12-01

hydrates: Differential scanning calorimetric measurements for the determination of the specific enthalpy of dissociation, determination of stability fields for pure and multicomponent systems, CH4 - CO2 -exchange reaction in clathrate hydrates and CO2 -hydrate formation in sediments under different pressure and temperature conditions were studied. Based on these fundamental data, new concepts for methane production and combined CO2 - sequestration will be presented and discussed. Reference: S.R. Dallimore, T.S. Collet (Eds.), 2005. Scientific Results from the Mallik 2002 Gas Hydrate Production Research Well Program, Mackenzie Delta, Northwest Territories, Canada, Geological Survey of Canada, WO H. Lee, Y. Seo, Y.-T. Seo, I.L. Moudrakovski, J.A. Ripmeester, 2003. Angewandte Chemie International Edition, 42, 5049-5051 A. Graue, B. Kvamme, 2006. Conference Paper presented at the Offshore Technology Conference in Houston, Texas, U.S.A., 1-4 May 2006 J.M. Schicks, R. Naumann, J. Erzinger, K.C. Hester, Caroly A. Koh, E.D. Sloan, 2006. Journal of Physical Chemistry, 110, 11468-11474

Aspects of black-fly control and entomology in the New World in relation to the Simulium problem in Nigeria*

PubMed Central

Crosskey, R. W.

1959-01-01

A general account is given of insecticidal control of black-flies in North and Central America, and the problems are contrasted with those arising in the control of Simulium damnosum Theo. in Nigeria. Some recent biological observations on Canadian black-flies are described, and it is emphasized that these have materially contributed to successful control. It is pointed out that S. damnosum control is being practised in the absence of much fundamental biological knowledge of this pest. Entomological aspects of onchocerciasis in Mexico and Guatemala are discussed, and compared with S. damnosum and its relationship to onchocerciasis in Nigeria. PMID:13813021

Fundamental insights into interfacial catalysis.

PubMed

Gong, Jinlong; Bao, Xinhe

2017-04-03

Surface and interfacial catalysis plays a vital role in chemical industries, electrochemistry and photochemical reactions. The challenges of modern chemistry are to optimize the chemical reaction processes and understand the detailed mechanism of chemical reactions. Since the early 1960s, the foundation of surface science systems has allowed the study of surface and interfacial phenomena on atomic/molecular level, and thus brought a number of significant developments to fundamental and technological processes, such as catalysis, material science and biochemistry, just to name a few. This themed issue describes the recent advances and developments in the fundamental understanding of surface and interfacial catalysis, encompassing areas of knowledge from metal to metal oxide, carbide, graphene, hexagonal boron nitride, and transition metal dichalcogenides under ultrahigh vacuum conditions, as well as under realistic reaction conditions.

The synthesis and crystal structure of 2-[4(S)-4,5-dihydro-4-phenyl-2-oxazolinyl]-benzenamine, and 2-[4(S)-4,5-dihydro-4-benzyl-2-oxazolinyl]-benzenamine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mei Luo, E-mail: Lmhh5523385@yahoo.cn; Hai Zhangjia; Hao Yin

2010-12-15

Two oxazolines compound 1a and 1b, 2-[4(S)-4,5-dihydro-4-phenyl-2-ozazolinyl-benzenamine, and (C{sub 15}H{sub 14}N{sub 2}O), 2-[4(S)-4,5-dihydro-4-benzyl-2-ozazolinyl-benzenamine (C{sub 16}H{sub 16}N{sub 2}O) were obtained in moderate yield from the reactions of 2-aminobenzonitrile with optically active L-(+)-Phenylglycinol and L-(+)-Phenylalaninol, respectively, in chlorobenzene under dry, anaerobic conditions. ZnCl{sub 2} was dried under vacuum and acted as a Lewis acid catalyst in this reaction. The structures of 1a and 1b were determined by X-ray diffraction and NMR. There exist intra- and intermolecular N-H-N hydrogen bonds in the crystal structure.

Evolution of educational inequalities in site-specific cancer mortality among Belgian men between the 1990s and 2000s using a "fundamental cause" perspective.

PubMed

Vanthomme, Katrien; Vandenheede, Hadewijch; Hagedoorn, Paulien; Gadeyne, Sylvie

2017-07-05

According to the "fundamental cause" theory, emerging knowledge on health-enhancing behaviours and technologies results in health disparities. This study aims to assess (trends in) educational inequalities in site-specific cancer mortality in Belgian men in the 1990s and the 2000s using this framework. Data were derived from record linkage between the Belgian censuses of 1991 and 2001 and register data on mortality. The study population comprised all Belgian men aged 50-79 years during follow-up. Both absolute and relative inequality measures have been calculated. Despite an overall downward trend in cancer mortality, educational differences are observed for the majority of cancer sites in the 2000s. Generally, inequalities are largest for mortality from preventable cancers. Trends over time in inequalities are rather stable compared with the 1990s. Educational differences in site-specific cancer mortality persist in the 2000s in Belgium, mainly for cancers related to behavioural change and medical interventions. Policy efforts focussing on behavioural change and healthcare utilization remain crucial in order to tackle these increasing inequalities.

EPA’s SPECIATE 4.4 Database:Development and Uses

EPA Science Inventory

SPECIATE is the U.S. Environmental Protection Agency's (EPA)repository of volatile organic gas and particulate matter (PM) speciation profiles for air pollution sources. EPA released SPECIATE 4.4 in early 2014 and, in total, the SPECIATE 4.4 database includes 5,728 PM, VOC, total...

EPA’s SPECIATE 4.4 Database: Development and Uses

EPA Science Inventory

SPECIATE is the U.S. Environmental Protection Agency's (EPA)repository of volatile organic gas and particulate matter (PM) speciation profiles for air pollution sources. EPA released SPECIATE 4.4 in early 2014 and, in total, the SPECIATE 4.4 database includes 5,728 PM, VOC, total...

Understanding the P×S Aspect of Within-Person Variation: A Variance Partitioning Approach

PubMed Central

Lakey, Brian

2016-01-01

This article reviews a variance partitioning approach to within-person variation based on Generalizability Theory and the Social Relations Model. The approach conceptualizes an important part of within-person variation as Person × Situation (P×S) interactions: differences among persons in their profiles of responses across the same situations. The approach provided the first quantitative method for capturing within-person variation and demonstrated very large P×S effects for a wide range of constructs. These include anxiety, five-factor personality traits, perceived social support, leadership, and task performance. Although P×S effects are commonly very large, conceptual, and analytic obstacles have thwarted consistent progress. For example, how does one develop a psychological, versus purely statistical, understanding of P×S effects? How does one forecast future behavior when the criterion is a P×S effect? How can understanding P×S effects contribute to psychological theory? This review describes potential solutions to these and other problems developed in the course of conducting research on the P×S aspect of social support. Additional problems that need resolution are identified. PMID:26858661

Fundamental Structure of High-Speed Reacting Flows: Supersonic Combustion and Detonation

DTIC Science & Technology

2016-04-30

AFRL-AFOSR-VA-TR-2016-0195 Fundamental Structure of High-Speed Reacting Flows: Supersonic Combustion and Detonation Kenneth Yu MARYLAND UNIV COLLEGE...MARCH 2016 4. TITLE AND SUBTITLE FUNDAMENTAL STRUCTURE OF HIGH-SPEED REACTING FLOWS: SUPERSONIC COMBUSTION AND DETONATION 5a. CONTRACT NUMBER...public release. Final Report on Fundamental Structure of High-Speed Reacting Flows: Supersonic Combustion and Detonation Grant

Transient-state biodegradation behavior of a horizontal biotrickling filter in co-treating gaseous H2S and NH3.

PubMed

Jiang, Xia; Yan, Rong; Tay, Joo Hwa

2009-01-01

A horizontal biotrickling filter (HBTF) was used to inoculate autotrophic sulfide-oxidizing and ammonia-oxidizing microbial consortiums over H2S-exhausted carbon for co-treating H2S and NH3 waste gas in a long-term operation. In this study, several aspects (i.e., pH change, shock loading and starvation) of the dynamic behavior of the HBTF were investigated. The metabolic products of N and S bearing species in recycling liquid and biological activities of the biofilm were analyzed to explain the observed phenomena and further explore the fundamentals behind. In the pH range of 4-8.5, although the removal efficiencies of H2S and NH3 remained 96-98% and 100%, respectively, the metabolic products demonstrated different removal mechanisms and pathways. NH4-N and NO2/NO3-N were dominated at pH < or = 6 and > or = 7, respectively, indicating the differentiated contributions from physical/chemical adsorption and bio-oxidation. Moreover, the HBTF demonstrated a good dynamic stability to withstand shock loadings by recovering immediately to the original. During shock loading, only 15.4% and 17.9% of captured H2S and NH3 was biodegraded, respectively. After 2, 11, and 48 days of starvation, the HBTF system reached a full performance within reasonable re-startup times (2-80 h), possibly due to the consumption of reduced S and N species in biomass or activated carbon thus converted into SO4-S and NO3-N during starvation period. The results helped to understand the fundamental knowledge by revealing the effects of pH and transient loadings linked with individual removal mechanism for H2S and NH3 co-treatment in different conditions.

Fundamentals and commercial aspects of nanobiosensors in point-of-care clinical diagnostics.

PubMed

Mahato, Kuldeep; Maurya, Pawan Kumar; Chandra, Pranjal

2018-03-01

Among various problems faced by mankind, health-related concerns are prevailing since long which are commonly found in the form of infectious diseases and different metabolic disorders. The clinical cure and management of such abnormalities are greatly dependent on the availability of their diagnoses. The conventional diagnostics used for such purposes are extremely powerful; however, most of these are limited by time-consuming protocols and require higher volume of test sample, etc. A new evolving technology called "biosensor" in this context shows an enormous potential for an alternative diagnostic device, which constantly compliments the conventional diagnoses. In this review, we have summarized different kinds of biosensors and their fundamental understanding with various state-of-the-art examples. A critical examination of different types of biosensing mechanisms is also reported highlighting the advantages of electrochemical biosensors for its great potentials in next-generation commercially viable modules. In recent years, a number of nanomaterials are extensively used to enhance not only the performance of biosensing mechanism, but also obtain robust, cheap, and fabrication-friendly durable mechanism. Herein, we have summarized the importance of nanomaterials in biosensing mechanism, their syntheses as well as characterization techniques. Subsequently, we have discussed the probe fabrication processes along with various techniques for assessing its analytical performances and potentials for commercial viability.

Linewidth studies on the the NI(4S-4P) resonance multiplet. [applicable to analysis of dayglow

NASA Technical Reports Server (NTRS)

Erdman, P. W.; Zipf, E. C.

1983-01-01

Doppler broadening of the 8691, 8212, and 1200-A multiplet lines of N I is investigated experimentally, and its implications for the interpretation of the earth's 1200-A UV dayglow are considered. A regulated 100-eV, 1-mA electron beam is passed through N2 at 300 K and about 0.0005 torr flowing through a collision chamber within a UHV system, and the radiation emitted is observed with a temperature-stabilized short-focal length monochromator with a bandpass of 0.2 A in the IR and an effective UV resolution (in second-order operation with a 3600-groove/mm plane grating) of about 0.04 A. Both the IR and VUV lines are found to be broadened to about 25 times the thermal Doppler linewidth, with the IR transitions accounting for more than half of the total N(4P) cross section at 100 eV. The kinetic energy of the N(4P) atoms produced by dissociative excitation is such that their 1200-A resonance radiation (2p2 3s4P - 2p3 4SO) would be optically thin in the upper atmosphere, contrary to what has been observed. A need to revise some aspects of current UV-dayglow models is identified.

Fundamental aspects of regenerative cerium oxide nanoparticles and their applications in nanobiotechnology

NASA Astrophysics Data System (ADS)

Patil, Swanand D.

Cerium oxide has been used extensively for various applications over the past two decades. The use of cerium oxide nanoparticles is beneficial in present applications and can open avenues for future applications. The present study utilizes the microemulsion technique to synthesize uniformly distributed cerium oxide nanoparticles. The same technique was also used to synthesize cerium oxide nanoparticles doped with trivalent elements (La and Nd). The fundamental study of cerium oxide nanoparticles identified variations in properties as a function of particle size and also due to doping with trivalent elements (La and Nd). It was found that the lattice parameter of cerium oxide nanoparticles increases with decrease in particle size. Also Raman allowed mode shift to lower energies and the peak at 464 cm-1 becomes broader and asymmetric. The size dependent changes in cerium oxide were correlated to increase in oxygen vacancy concentration in the cerium oxide lattice. The doping of cerium oxide nanoparticles with trivalent elements introduces more oxygen vacancies and expands the cerium oxide lattice further (in addition to the lattice expansion due to the size effect). The lattice expansion is greater for La-doped cerium oxide nanoparticles compared to Nd-doping due to the larger ionic radius of La compared to Nd, the lattice expansion is directly proportional to the dopant concentration. The synthesized cerium oxide nanoparticles were used to develop an electrochemical biosensor of hydrogen peroxide (H2O2). The sensor was useful to detect H2O2 concentrations as low as 1muM in water. Also the preliminary testing of the sensor on tomato stem and leaf extracts indicated that the sensor can be used in practical applications such as plant physiological studies etc. The nanomolar concentrations of cerium oxide nanoparticles were also found to be useful in decreasing ROS (reactive oxygen species) mediated cellular damages in various in vitro cell cultures. Cerium oxide

An Overview of Preliminary Computational and Experimental Results for the Semi-Span Super-Sonic Transport (S4T) Wind-Tunnel Model

NASA Technical Reports Server (NTRS)

Silva, Walter A.; Perry, Boyd, III; Florance, James R.; Sanetrik, Mark D.; Wieseman, Carol D.; Stevens, William L.; Funk, Christie J.; Hur, Jiyoung; Christhilf, David M.; Coulson, David A.

2011-01-01

A summary of computational and experimental aeroelastic and aeroservoelastic (ASE) results for the Semi-Span Super-Sonic Transport (S4T) wind-tunnel model is presented. A broad range of analyses and multiple ASE wind-tunnel tests of the S4T have been performed in support of the ASE element in the Supersonics Program, part of NASA's Fundamental Aeronautics Program. The computational results to be presented include linear aeroelastic and ASE analyses, nonlinear aeroelastic analyses using an aeroelastic CFD code, and rapid aeroelastic analyses using CFD-based reduced-order models (ROMs). Experimental results from two closed-loop wind-tunnel tests performed at NASA Langley's Transonic Dynamics Tunnel (TDT) will be presented as well.

Fundamental science behind today's important medicines.

PubMed

Spector, Jonathan M; Harrison, Rosemary S; Fishman, Mark C

2018-04-25

Today's most transformative medicines exist because of fundamental discoveries that were made without regard to practical outcome and with their relevance to therapeutics only appearing decades later. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

AsS-Tl/sub 3/AsS/sub 4/ and AsS-Tl/sub 2/S systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vorob'ev, Yu.I.; Velikova, N.G.; Kirilenko, V.V.

1987-11-01

Using DTA and XPA as well as microstructural analysis and microhardness measurements, the AsS-Tl/sub 3/AsS/sub 4/ and AsS-Tl/sub 2/S phase diagrams are studied. Two new ternary compounds, Tl/sub 2/As/sub 3/S/sub 4/ and Tl/sub 2/As/sub 2/S/sub 3/, are revealed and their interplanar distances are calculated.

Proceedings of the 2003 NASA/JPL Workshop on Fundamental Physics in Space

NASA Technical Reports Server (NTRS)

Strayer, Don (Editor)

2003-01-01

The 2003 Fundamental Physics workshop included presentations ranging from forces acting on RNA to properties of clouds of degenerate Fermi atoms, to techniques to probe for a added space-time dimensions, and to flight hardware for low temperature experiments, amongst others. Mark Lee from NASA Headquarters described the new strategic plan that NASA has developed under Administrator Sean O'Keefe's leadership. Mark explained that the Fundamental Physics community now needs to align its research program and the roadmap describing the long-term goals of the program with the NASA plan. Ulf Israelsson of JPL discussed how the rewrite of the roadmap will be implemented under the leadership of the Fundamental Physics Discipline Working Group (DWG). Nick Bigelow, chair of the DWG, outlined how investigators can contribute to the writing of the roadmap. Results of measurements on very cold clouds of Fermi atoms near a Feshbach resonance were described by three investigators. Also, new measurements relating to tests of Einstein equivalence were discussed. Investigators also described methods to test other aspects of Einstein's relativity theories.

Fundamental plasma emission involving ion sound waves

NASA Technical Reports Server (NTRS)

Cairns, Iver H.

1987-01-01

The theory for fundamental plasma emission by the three-wave processes L + or - S to T (where L, S and T denote Langmuir, ion sound and transverse waves, respectively) is developed. Kinematic constraints on the characteristics and growth lengths of waves participating in the wave processes are identified. In addition the rates, path-integrated wave temperatures, and limits on the brightness temperature of the radiation are derived.

MICROWAVE SPECTROSCOPY OF THE CALCIUM 4snf→4s(n+1)d, 4sng, 4snh, 4sni, AND 4snk TRANSITIONS

NASA Astrophysics Data System (ADS)

Nunkaew, Jirakan; Gallagher, Tom

2015-06-01

We use a delayed field ionization technique to observe the microwave transitions of calcium Rydberg states, from the 4snf states to the 4s(n+1)d, 4sng, 4snh, 4sni, and 4snk states for 18≤ n≤23. We analyze the observed intervals between the ℓ and (ℓ+1), ℓ≥5, states of the same n to determine the Ca^+ 4s dipole and quadrupole polarizabilities. We show that the adiabatic core polarization model is not adequate to extract the Ca^+ 4s dipole and quadrupole polarizabilities and a non adiabatic treatment is required. We use the non adiabatic core polarization model to determine the ionic dipole and quadrupole polarizabilities to be α_d=76.9(3);a_0^3 and α_q=206(9);a_0^5, respectively.

Fundamental Aspects of Pressuremeter Testing.

DTIC Science & Technology

1987-04-30

consolidomreter is giveln ill Fig. 3.1. To reduce the consolidation time, drainage is provided at the top and botton , of the specimen. A detailed mechanical...OCf I. f,1 rr cal stait so, m~ode ~1, ThC ( ;1!1. ( Ia fl-- lot a! 9 an(.- tf. n’’.j" .. ( amn CIa, (ko-tem and 1Biriii. 1140% are it.o tt3’ (d i...plane strain tests, the intermediate principal stress is [ lot known unless the sides of the specinien corresponding to the plane of zero deform-a

Descriptions of fundamental care needs in cancer care-An exploratory study.

PubMed

Muntlin Athlin, Åsa; Brovall, Maria; Wengström, Yvonne; Conroy, Tiffany; Kitson, Alison L

2018-06-01

To explore the experiences of the fundamentals of care for people with a cancer diagnosis, from diagnosis to after adjuvant treatment. More focus is needed on the experience of people living with cancer, as current cancer care more emphasises on independence and resilience without fully acknowledging that there will be moments in the cancer journey where patients will need "basic nursing care" to manage their symptoms and care pathways. Secondary analysis of qualitative data. Secondary thematic analysis of interview data from 30 people with a diagnosis of breast (n = 10), colorectal (n = 10) or prostate (n = 10) cancer was undertaken. The findings revealed vivid descriptions of the fundamentals of care (i.e., basic needs) and participants described physical, psychosocial and relational aspects of the delivery of care. Both positive (e.g., supportive and kind) and negative (e.g., humiliating) experiences related to the relationship with the healthcare professionals were re-counted and affected the participants' experiences of the fundamentals of care. Participants' accounts of their fundamental care needs were provided without them identifying who, within the healthcare system, was responsible for providing these needs. Specific nursing interventions were seldom described. Some people with a cancer diagnosis have to strive for help and support from the nursing staff to manage to regain control over their recovery. Nurses in cancer care need to focus on the patients' fundamental care needs to optimise their patients' recovery. Cancer patients require support with their fundamental care needs and nurses need to be more aware of this and integrate it into the caring relationship. It is imperative that the complexity of the nurse-patient relationship is acknowledged and that models of care which honour this complexity are used. © 2018 John Wiley & Sons Ltd.

Evaluating fundamentals of care: The development of a unit-level quality measurement and improvement programme.

PubMed

Parr, Jenny M; Bell, Jeanette; Koziol-McLain, Jane

2018-06-01

The project aimed to develop a unit-level quality measurement and improvement programme using evidence-based fundamentals of care. Feedback from patients, families, whānau, staff and audit data in 2014 indicated variability in the delivery of fundamental aspects of care such as monitoring, nutrition, pain management and environmental cleanliness at a New Zealand District Health Board. A general inductive approach was used to explore the fundamentals of care and design a measurement and improvement programme, the Patient and Whānau Centred Care Standards (PWCCS), focused on fundamental care. Five phases were used to explore the evidence, and design and test a measurement and improvement framework. Nine identified fundamental elements of care were used to define expected standards of care and develop and test a measurement and improvement framework. Four six-monthly peer reviews have been undertaken since June 2015. Charge Nurse Managers used results to identify quality improvements. Significant improvement was demonstrated overall, in six of the 27 units, in seven of the nine standards and three of the four measures. In all, 89% (n = 24) of units improved their overall result. The PWCCS measurement and improvement framework make visible nursing fundamentals of care in line with continuous quality improvement to increase quality of care. Delivering fundamentals of care is described by nurses as getting ?back to basics'. Patient and family feedback supports the centrality of fundamentals of care to their hospital experience. Implementing a unit-level fundamentals of care quality measurement and improvement programme clarifies expected standards of care, highlights the contribution of fundamentals of care to quality and provides a mechanism for ongoing improvements. © 2018 John Wiley & Sons Ltd.

When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches.

PubMed

Muñoz, Victor; Cerminara, Michele

2016-09-01

Protein folding research stalled for decades because conventional experiments indicated that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay between dynamics and energetics resulting in myriad microscopic pathways. Ultrafast kinetic methods turned the field upside down by providing the means to probe fundamental aspects of folding, test theoretical predictions and benchmark simulations. Accordingly, experimentalists could measure the timescales for all relevant folding motions, determine the folding speed limit and confirm that folding barriers are entropic bottlenecks. Moreover, a catalogue of proteins that fold extremely fast (microseconds) could be identified. Such fast-folding proteins cross shallow free energy barriers or fold downhill, and thus unfold with minimal co-operativity (gradually). A new generation of thermodynamic methods has exploited this property to map folding landscapes, interaction networks and mechanisms at nearly atomic resolution. In parallel, modern molecular dynamics simulations have finally reached the timescales required to watch fast-folding proteins fold and unfold in silico All of these findings have buttressed the fundamentals of protein folding predicted by theory, and are now offering the first glimpses at the underlying mechanisms. Fast folding appears to also have functional implications as recent results connect downhill folding with intrinsically disordered proteins, their complex binding modes and ability to moonlight. These connections suggest that the coupling between downhill (un)folding and binding enables such protein domains to operate analogically as conformational rheostats. © 2016 The Author(s).

Diagnostic and interventional musculoskeletal ultrasound: part 1. Fundamentals.

PubMed

Smith, Jay; Finnoff, Jonathan T

2009-01-01

Musculoskeletal ultrasound involves the use of high-frequency sound waves to image soft tissues and bony structures in the body for the purposes of diagnosing pathology or guiding real-time interventional procedures. Recently, an increasing number of physicians have integrated musculoskeletal ultrasound into their practices to facilitate patient care. Technological advancements, improved portability, and reduced costs continue to drive the proliferation of ultrasound in clinical medicine. This increased interest creates a need for education pertaining to all aspects of musculoskeletal ultrasound. The primary purpose of this article is to review diagnostic ultrasound technology and its potential clinical applications in the evaluation and treatment of patients with neurologic and musculoskeletal disorders. After reviewing this article, physicians should be able to (1) list the advantages and disadvantages of ultrasound compared with other available imaging modalities, (2) describe how ultrasound machines produce images using sound waves, (3) discuss the steps necessary to acquire and optimize an ultrasound image, (4) understand the different ultrasound appearances of tendons, nerves, muscles, ligaments, blood vessels, and bones, and (5) identify multiple applications for diagnostic and interventional musculoskeletal ultrasound in musculoskeletal practice. Part 1 of this 2-part article reviews the fundamentals of clinical ultrasonographic imaging, including relevant physics, equipment, training, image optimization, and scanning principles for diagnostic and interventional purposes.

Educational Influences on Young People's Support for Fundamental British Values

ERIC Educational Resources Information Center

Janmaat, Jan Germen

2018-01-01

In 2014 the British government called on schools to actively promote fundamental British values (FBVs), seeing this as an effective way to prevent the radicalisation of young people. The government considers these values to include democracy, individual liberty, the rule of law and respect for people of different backgrounds and religions. Rather…

Biotransformation of (-)-(1R,4S)-Menthone and (+)-(1S,4R)-Menthone by the Common Cutworm Spodoptera litura Larvae.

PubMed

Marumoto, Shinsuke; Okuno, Yoshiharu; Hagiwara, Yuki; Miyazawa, Mitsuo

2017-08-01

Using biotransformation as a biocatalytic process has the advantage of being able to proceed under mild conditions and with high regio- and enantioselectivity. This study investigated the biotransformation of (-)-(1R,4S)-menthone (1) and (+)-(1S,4R)-menthone (2) by Spodoptera litura larvae. Compound 1 was converted to (-)-(1R,4S)-7-hydroxymenthone (1-1), (+)-(1R,3S,4S)-7-hydroxyneomenthol (1-2) and (-)-(1R,4S,8R)-p-menth-3-one-9-oic acid (1-3). The metabolism of substrate 2 generated three enantiomers of the above metabolites, designated as 2-1 to 2-3, respectively. The C-9 position of (-)-menthone and (+)-menthone was oxidized to carboxylic acid by S. litura, which is a metabolic pathway not observed in any other example of biocatalysis.

The effect of age, sex and obesity on fundamental motor skills among 4 to 6 years-old children.

PubMed

Vameghi, Roshanak; Shams, Amir; Shamsipour Dehkordi, Parvane

2013-04-01

To examine the effect of age, sex and obesity on Fundamental Motor Skills (FMS) in 4 to 6 years-old children. A total of 400 preschool children (200 boys and 200 girls) between the ages of 4 to 6 years old participated in this research. Subjects were selected through multi-stage cluster random sampling. Fundamental motor skills (FMS) were assessed with using the OSU-SIGMA scale. Body mass index (BMI) was directly measured from height(m)(2)/weight(kg) for each child and based on CDC growth charts, normal weight, overweight and obesity were defined. The results showed that age and sex variables were a significant effect on walking and running skills, but BMI was not significant (P>0.05). Also, these variables had a significant effect on jumping, skipping, hopping and ladder climbing. In both ages, boys in jumping and ladder climbing skills were better than girls, but the girls were better in skipping and hopping skills (P<0.05). Moreover, the results showed that age and BMI variables have a significant effect on stair climbing skill, but sex was not significant (P>0.05). For object control skills, the results showed that age and sex variables were a significant effect on catching and throwing skills, but BMI was not significant (P>0.05). Finally, the age, sex and BMI variables were a significant effect on kicking and sticking skills. This research demonstrated that boys performed better than girls, and both overweight and obese children have lower performance than normal children.

Py4CAtS - Python tools for line-by-line modelling of infrared atmospheric radiative transfer

NASA Astrophysics Data System (ADS)

Schreier, Franz; García, Sebastián Gimeno

2013-05-01

Py4CAtS — Python scripts for Computational ATmospheric Spectroscopy is a Python re-implementation of the Fortran infrared radiative transfer code GARLIC, where compute-intensive code sections utilize the Numeric/Scientific Python modules for highly optimized array-processing. The individual steps of an infrared or microwave radiative transfer computation are implemented in separate scripts to extract lines of relevant molecules in the spectral range of interest, to compute line-by-line cross sections for given pressure(s) and temperature(s), to combine cross sections to absorption coefficients and optical depths, and to integrate along the line-of-sight to transmission and radiance/intensity. The basic design of the package, numerical and computational aspects relevant for optimization, and a sketch of the typical workflow are presented.

Hierarchical NiCo2 S4 Nanotube@NiCo2 S4 Nanosheet Arrays on Ni Foam for High-Performance Supercapacitors.

PubMed

Chen, Haichao; Chen, Si; Shao, Hongyan; Li, Chao; Fan, Meiqiang; Chen, Da; Tian, Guanglei; Shu, Kangying

2016-01-01

Hierarchical NiCo2 S4 nanotube@NiCo2 S4 nanosheet arrays on Ni foam have been successfully synthesized. Owing to the unique hierarchical structure, enhanced capacitive performance can be attained. A specific capacitance up to 4.38 F cm(-2) is attained at 5 mA cm(-2) , which is much higher than the specific capacitance values of NiCo2 O4 nanosheet arrays, NiCo2 S4 nanosheet arrays and NiCo2 S4 nanotube arrays on Ni foam. The hierarchical NiCo2 S4 nanostructure shows superior cycling stability; after 5000 cycles, the specific capacitance still maintains 3.5 F cm(-2) . In addition, through the morphology and crystal structure measurement after cycling stability test, it is found that the NiCo2 S4 electroactive materials are gradually corroded; however, the NiCo2 S4 phase can still be well-maintained. Our results show that hierarchical NiCo2 S4 nanostructures are suitable electroactive materials for high performance supercapacitors. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Syntheses, structural variants and characterization of AInM′S{sub 4} (A=alkali metals, Tl; M′ = Ge, Sn) compounds; facile ion-exchange reactions of layered NaInSnS{sub 4} and KInSnS{sub 4} compounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yohannan, Jinu P.; Vidyasagar, Kanamaluru, E-mail: kvsagar@iitm.ac.in

Ten AInM′S{sub 4} (A=alkali metals, Tl; M′= Ge, Sn) compounds with diverse structure types have been synthesized and characterized by single crystal and powder X-ray diffraction and a variety of spectroscopic methods. They are wide band gap semiconductors. KInGeS{sub 4}(1-β), RbInGeS{sub 4}(2), CsInGeS{sub 4}(3-β), TlInGeS{sub 4}(4-β), RbInSnS{sub 4}(8-β) and CsInSnS{sub 4}(9) compounds with three-dimensional BaGa{sub 2}S{sub 4} structure and CsInGeS{sub 4}(3-α) and TlInGeS{sub 4}(4-α) compounds with a layered TlInSiS{sub 4} structure have tetrahedral [InM′S{sub 4}]{sup −} frameworks. On the other hand, LiInSnS{sub 4}(5) with spinel structure and NaInSnS{sub 4}(6), KInSnS{sub 4}(7), RbInSnS{sub 4}(8-α) and TlInSnS{sub 4}(10) compounds with layered structuremore » have octahedral [InM′S{sub 4}]{sup −} frameworks. NaInSnS{sub 4}(6) and KInSnS{sub 4}(7) compounds undergo facile topotactic ion-exchange, at room temperature, with various mono-, di- and tri-valent cations in aqueous medium to give rise to metastable layered phases. - Graphical abstract: NaInSnS{sub 4} and KInSnS{sub 4} compounds undergo, in aqueous medium at room temperature, facile topotactic ion-exchange with mono, di and trivalent cations. Display Omitted - Highlights: • Ten AInM′S{sub 4} compounds with diverse structure types were synthesized. • They are wide band gap semiconductors. • NaInSnS{sub 4} and KInSnS{sub 4} compounds undergo facile topotactic ion-exchange at room temperature.« less

High temperature neutron powder diffraction study of the Cu12Sb4S13 and Cu4Sn7S16 phases

NASA Astrophysics Data System (ADS)

Lemoine, Pierric; Bourgès, Cédric; Barbier, Tristan; Nassif, Vivian; Cordier, Stéphane; Guilmeau, Emmanuel

2017-03-01

Ternary copper-containing sulfides Cu12Sb4S13 and Cu4Sn7S16 have attracted considerable interest since few years due to their high-efficiency conversion as absorbers for solar energy and promising thermoelectric materials. We report therein on the decomposition study of Cu12Sb4S13 and Cu4Sn7S16 phases using high temperature in situ neutron powder diffraction. Our results obtained at a heating rate of 2.5 K/min indicate that: (i) Cu12Sb4S13 decomposes above ≈792 K into Cu3SbS3, and (ii) Cu4Sn7S16 decomposes above ≈891 K into Sn2S3 and a copper-rich sulfide phase of sphalerite ZnS-type structure with an assumed Cu3SnS4 stoichiometry. Both phase decompositions are associated to a sulfur volatilization. While the results on Cu12Sb4S13 are in fair agreement with recent published data, the decomposition behavior of Cu4Sn7S16 differs from other studies in terms of decomposition temperature, thermal stability and products of reaction. Finally, the crystal structure refinements from neutron powder diffraction data are reported and discussed for the Cu4Sn7S16 and tetrahedrite Cu12Sb4S13 phases at 300 K, and for the high temperature form of skinnerite Cu3SbS3 at 843 K.

Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type CaV3.3 channels.

PubMed

Sanchez-Sandoval, Ana Laura; Herrera Carrillo, Zazil; Díaz Velásquez, Clara Estela; Delgadillo, Dulce María; Rivera, Heriberto Manuel; Gomora, Juan Carlos

2018-01-01

Voltage-gated calcium channels contain four highly conserved transmembrane helices known as S4 segments that exhibit a positively charged residue every third position, and play the role of voltage sensing. Nonetheless, the activation range between high-voltage (HVA) and low-voltage (LVA) activated calcium channels is around 30-40 mV apart, despite the high level of amino acid similarity within their S4 segments. To investigate the contribution of S4 voltage sensors for the low-voltage activation characteristics of CaV3.3 channels we constructed chimeras by swapping S4 segments between this LVA channel and the HVA CaV1.2 channel. The substitution of S4 segment of Domain II in CaV3.3 by that of CaV1.2 (chimera IIS4C) induced a ~35 mV shift in the voltage-dependence of activation towards positive potentials, showing an I-V curve that almost overlaps with that of CaV1.2 channel. This HVA behavior induced by IIS4C chimera was accompanied by a 2-fold decrease in the voltage-dependence of channel gating. The IVS4 segment had also a strong effect in the voltage sensing of activation, while substitution of segments IS4 and IIIS4 moved the activation curve of CaV3.3 to more negative potentials. Swapping of IIS4 voltage sensor influenced additional properties of this channel such as steady-state inactivation, current decay, and deactivation. Notably, Domain I voltage sensor played a major role in preventing CaV3.3 channels to inactivate from closed states at extreme hyperpolarized potentials. Finally, site-directed mutagenesis in the CaV3.3 channel revealed a partial contribution of the S4-S5 linker of Domain II to LVA behavior, with synergic effects observed in double and triple mutations. These findings indicate that IIS4 and, to a lesser degree IVS4, voltage sensors are crucial in determining the LVA properties of CaV3.3 channels, although the accomplishment of this function involves the participation of other structural elements like S4-S5 linkers.

Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type CaV3.3 channels

PubMed Central

Sanchez-Sandoval, Ana Laura; Herrera Carrillo, Zazil; Díaz Velásquez, Clara Estela; Delgadillo, Dulce María; Rivera, Heriberto Manuel

2018-01-01

Voltage-gated calcium channels contain four highly conserved transmembrane helices known as S4 segments that exhibit a positively charged residue every third position, and play the role of voltage sensing. Nonetheless, the activation range between high-voltage (HVA) and low-voltage (LVA) activated calcium channels is around 30–40 mV apart, despite the high level of amino acid similarity within their S4 segments. To investigate the contribution of S4 voltage sensors for the low-voltage activation characteristics of CaV3.3 channels we constructed chimeras by swapping S4 segments between this LVA channel and the HVA CaV1.2 channel. The substitution of S4 segment of Domain II in CaV3.3 by that of CaV1.2 (chimera IIS4C) induced a ~35 mV shift in the voltage-dependence of activation towards positive potentials, showing an I-V curve that almost overlaps with that of CaV1.2 channel. This HVA behavior induced by IIS4C chimera was accompanied by a 2-fold decrease in the voltage-dependence of channel gating. The IVS4 segment had also a strong effect in the voltage sensing of activation, while substitution of segments IS4 and IIIS4 moved the activation curve of CaV3.3 to more negative potentials. Swapping of IIS4 voltage sensor influenced additional properties of this channel such as steady-state inactivation, current decay, and deactivation. Notably, Domain I voltage sensor played a major role in preventing CaV3.3 channels to inactivate from closed states at extreme hyperpolarized potentials. Finally, site-directed mutagenesis in the CaV3.3 channel revealed a partial contribution of the S4-S5 linker of Domain II to LVA behavior, with synergic effects observed in double and triple mutations. These findings indicate that IIS4 and, to a lesser degree IVS4, voltage sensors are crucial in determining the LVA properties of CaV3.3 channels, although the accomplishment of this function involves the participation of other structural elements like S4-S5 linkers. PMID:29474447

Preparation, properties and anticancer effects of mixed As4S4/ZnS nanoparticles capped by Poloxamer 407.

PubMed

Bujňáková, Z; Baláž, M; Zdurienčíková, M; Sedlák, J; Čaplovičová, M; Čaplovič, Ľ; Dutková, E; Zorkovská, A; Turianicová, E; Baláž, P; Shpotyuk, O; Andrejko, S

2017-02-01

Arsenic sulfide compounds have a long history of application in a traditional medicine. In recent years, realgar has been studied as a promising drug in cancer treatment. In this study, the arsenic sulfide (As 4 S 4 ) nanoparticles combined with zinc sulfide (ZnS) ones in different molar ratio have been prepared by a simple mechanochemical route in a planetary mill. The successful synthesis and structural properties were confirmed and followed via X-ray diffraction and high-resolution transmission electron microscopy measurements. The morphology of the particles was studied via scanning electron microscopy and transmission electron microscopy methods and the presence of nanocrystallites was verified. For biological tests, the prepared As 4 S 4 /ZnS nanoparticles were further milled in a circulation mill in a water solution of Poloxamer 407 (0.5wt%), in order to cover the particles with this biocompatible copolymer and to obtain stable nanosuspensions with unimodal distribution. The average size of the particles in the nanosuspensions (~120nm) was determined by photon cross-correlation spectroscopy method. Stability of the nanosuspensions was determined via particle size distribution and zeta potential measurements, confirming no physico-chemical changes for several months. Interestingly, with the increasing amount of ZnS in the sample, the stability was improved. The anti-cancer effects were tested on two melanoma cell lines, A375 and Bowes, with promising results, confirming increased efficiency of the samples containing both As 4 S 4 and ZnS nanocrystals. Copyright © 2016 Elsevier B.V. All rights reserved.

Mechanistic studies on the reactions of PhS(-) or [MoS(4)](2)(-) with [M(4)(SPh)(10)](2)(-) (M = Fe or Co).

PubMed

Cui, Zhen; Henderson, Richard A

2002-08-12

Kinetic studies, using stopped-flow spectrophotometry, on the reactions of [M(4)(SPh)(10)](2)(-) (M = Fe or Co) with PhS(-) to form [M(SPh)(4)](2)(-) are described, as are the reactions between [M(4)(SPh)(10)](2)(-) and [MoS(4)](2)(-) to form [S(2)MoS(2)Fe(SPh)(2)](2)(-) or [S(2)MoS(2)CoS(2)MoS(2)](2)(-). The kinetics of the reactions with PhS(-) are consistent with an initial associative substitution mechanism involving attack of PhS(-) at one of the tetrahedral M sites of [M(4)(SPh)(10)](2)(-) to form [M(4)(SPh)(11)](3)(-). Subsequent or concomitant cleavage of a micro-SPh ligand, at the same M, initiates a cascade of rapid reactions which result ultimately in the complete rupture of the cluster and formation of [M(SPh)(4)](2)(-). The kinetics of the reaction between [M(4)(SPh)(10)](2)(-) and [MoS(4)](2)(-) indicate an initial dissociative substitution mechanism at low concentrations of [MoS(4)](2)(-), in which rate-limiting dissociation of a terminal thiolate from [M(4)(SPh)(10)](2)(-) produces [M(4)(SPh)(9)](-) and the coordinatively unsaturated M site is rapidly attacked by a sulfido group of [MoS(4)](2)(-). It is proposed that subsequent chelation of the MoS(4) ligand results in cleavage of an M-micro-SPh bond, initiating a cascade of reactions which lead to the ultimate break-up of the cluster and formation of the products, [S(2)MoS(2)Fe(SPh)(2)](2)(-) or [S(2)MoS(2)CoS(2)MoS(2)](2)(-). With [Co(4)(SPh)(10)](2)(-), at higher concentrations of [MoS(4)](2)(-), a further substitution pathway is evident which exhibits a second order dependence on the concentration of [MoS(4)](2)(-). The mechanistic picture of cluster disruption which emerges from these studies rationalizes the "all or nothing" reactivity of [M(4)(SPh)(10)](2)(-).

Effect of Cell Aspect Ratio on Swarming Bacteria

NASA Astrophysics Data System (ADS)

Ilkanaiv, Bella; Kearns, Daniel B.; Ariel, Gil; Be'er, Avraham

2017-04-01

Swarming bacteria collectively migrate on surfaces using flagella, forming dynamic whirls and jets that consist of millions of individuals. Because some swarming bacteria elongate prior to actual motion, cell aspect ratio may play a significant role in the collective dynamics. Extensive research on self-propelled rodlike particles confirms that elongation promotes alignment, strongly affecting the dynamics. Here, we study experimentally the collective dynamics of variants of swarming Bacillus subtilis that differ in length. We show that the swarming statistics depends on the aspect ratio in a critical, fundamental fashion not predicted by theory. The fastest motion was obtained for the wild-type and variants that are similar in length. However, shorter and longer cells exhibit anomalous, non-Gaussian statistics and nonexponential decay of the autocorrelation function, indicating lower collective motility. These results suggest that the robust mechanisms to maintain aspect ratios may be important for efficient swarming motility. Wild-type cells are optimal in this sense.

Deletion of the S3–S4 Linker in theShaker Potassium Channel Reveals Two Quenching Groups near the outside of S4

PubMed Central

Sørensen, J.B.; Cha, A.; Latorre, R.; Rosenman, E.; Bezanilla, F.

2000-01-01

When attached outside the voltage-sensing S4 segment of the Shaker potassium channel, the fluorescent probe tetramethylrhodamine (TMRM) undergoes voltage-dependent fluorescence changes (ΔF) due to differential interaction with a pH-titratable external protein-lined vestibule (Cha, A., and F. Bezanilla. 1998. J. Gen. Physiol. 112:391–408.). We attached TMRM at the same sites [corresponding to M356C and A359C in the wild-type (wt) channel] in a deletion mutant of Shaker where all but the five amino acids closest to S4 had been removed from the S3–S4 linker. In the deletion mutant, the maximal ΔF/F seen was diminished 10-fold, and the ΔF at M356C became pH independent, suggesting that the protein-lined vestibule is made up in large part by the S3–S4 linker. The residual ΔF showed that the probe still interacted with two putative quenching groups near the S4 segment. One group was detected by M356C-TMRM (located outside of S3 in the deletion mutant) and reported on deactivation gating charge movement when applying hyperpolarizing voltage steps from a holding potential of 0 mV. During activating voltage steps from a holding potential of −90 mV, the fluorescence lagged considerably behind the movement of gating charge over a range of potentials. Another putative quenching group was seen by probes attached closer to the S4 and caused a ΔF at extreme hyperpolarizations (more negative than −90 mV) only. A signal from the interaction with this group in the wt S3–S4 linker channel (at L361C) correlated with gating charge moving in the hyperpolarized part of the Q-V curve. Probe attached at A359C in the deletion mutant and at L361C in wt channel showed a biphasic ΔF as the probe oscillated between the two groups, revealing that there is a transient state of the voltage sensor in between, where the probe has maximal fluorescence. We conclude that the voltage sensor undergoes two distinct conformational changes as seen from probes attached outside the S4

Exchange Rates and Fundamentals.

ERIC Educational Resources Information Center

Engel, Charles; West, Kenneth D.

2005-01-01

We show analytically that in a rational expectations present-value model, an asset price manifests near-random walk behavior if fundamentals are I (1) and the factor for discounting future fundamentals is near one. We argue that this result helps explain the well-known puzzle that fundamental variables such as relative money supplies, outputs,…

Allowing for crystalline structure effects in Geant4

DOE PAGES

Bagli, Enrico; Asai, Makoto; Dotti, Andrea; ...

2017-03-24

In recent years, the Geant4 toolkit for the Monte Carlo simulation of radiation with matter has seen large growth in its divers user community. A fundamental aspect of a successful physics experiment is the availability of a reliable and precise simulation code. Geant4 currently does not allow for the simulation of particle interactions with anything other than amorphous matter. To overcome this limitation, the GECO (GEant4 Crystal Objects) project developed a general framework for managing solid-state structures in the Geant4 kernel and validate it against experimental data. As a result, accounting for detailed geometrical structures allows, for example, simulation ofmore » diffraction from crystal planes or the channeling of charged particle.« less

High-resolution Fourier transform infrared spectroscopy and analysis of the ν12 fundamental band of ethylene- d4

NASA Astrophysics Data System (ADS)

Tan, T. L.; Goh, K. L.; Ong, P. P.; Teo, H. H.

1999-12-01

The Fourier transform infrared (IR) spectrum of the ν12 fundamental band of ethylene- d4 (C 2D 4) has been measured with an unapodized resolution of 0.004 cm -1 in the frequency range of 1030-1130 cm -1. A total of 1340 assigned transitions have been analyzed and fitted using a Watson's A-reduced Hamiltonian in the Ir representation to derive rovibrational constants for the upper state ( v12=1) up to five quartic terms with a standard deviation of 0.00042 cm -1. They represent the most accurate constants for the band thus far. The ground state rovibrational constants were also further improved by a fit of combination-differences from the IR measurements. The relatively unperturbed band was found to be basically A-type with a band centre at 1076.98492±0.00003 cm -1.

Asymmetric conjugate 1,4-addition of arylboronic acids to alpha, beta-unsaturated esters catalyzed by Rhodium(I)/(S)-binap

PubMed

Sakuma; Sakai; Itooka; Miyaura

2000-09-22

Arylboronic acids underwent the conjugate 1,4-addition to alpha, beta-unsaturated esters to give beta-aryl esters in high yields in the presence of a rhodium(I) catalyst. The addition of arylboronic acids to isopropyl crotonate resulted in high yields and high enantioselectivity exceeding 90% ee in the presence of 3 mol % of Rh(acac)(C(2)H(4))(2) and (S)-binap at 100 degrees C. The rhodium/(S)-binap complex provided (R)-3-phenylbutanoate in the addition of phenylboronic acid to benzyl crotonate. The effects on the enantioselectivity of chiral phosphine ligands, rhodium precursors, and substituents on alpha,beta-unsaturated esters are discussed, as well as the mechanistic aspect of the catalytic cycle.

First Principles Investigation of the Geometrical and Electrochemical Properties of Na4P<S6 and Li4P2S6

NASA Astrophysics Data System (ADS)

Rush, Larry E., Jr.; Holzwarth, N. A. W.

First principles simulations are used to examine the structural and physical properties of Na4P2S6 in comparison with its Li4P2S6 analog. Four model structures are considered including the C 2 / m structure recently reported by Kuhn and co-workers from their analysis of single crystals of Na4P2S6, and three structures related to the P63 / mcm structure with P site disorder found in 1982 by Mercier and co-workers from their analysis of single crystals of Li4P2S6. The computational results indicate that both Na4P2S6 and Li4P2S6 have the same disordered ground state structures consistent with the P63 / mcm space group, while the optimized C 2 / m structures have higher energies by 0.1 eV and 0.4 eV per formula unit for Na4P2S6 and Li4P2S6, respectively. Simulations of ion migration suggest that Na4P2S6 may have more favorable ionic conductivity compared to Li4P2S6. Supported by NSF Grant DMR-1105485 and DMR-1507942.

Novel Solution Process for Fabricating Ultra-Thin-Film Absorber Layers in Fe 2SiS 4 and Fe 2GeS 4 Photovoltaics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orefuwa, Samuel A.; Lai, Cheng-Yu; Dobson, Kevin D.

2014-05-12

Fe 2SiS 4 and Fe 2GeS 4 crystalline materials posses direct bandgaps of ~1.55 and ~1.4 eV respectively and an absorption coefficient larger than 10^5 cm–1; their theoretical potential as solar photovoltaic absorbers has been demonstrated. However, no solar devices that employ either Fe 2SiS 4 or Fe 2GeS 4 have been reported to date. In the presented work, nanoprecursors to Fe 2SiS 4 and Fe 2GeS 4 have been fabricated and employed to build ultra-thin-film layers via spray coating and rod coating methods. Temperature-dependent X-Ray diffraction analyses of nanoprecursors coatings show an unprecedented low temperature for forming crystalline Femore » 2SiS 4 and Fe 2GeS 4. Fabricating of ultra-thin-film photovoltaic devices utilizing Fe 2SiS 4 and Fe 2GeS 4 as solar absorber material is presented.« less

Synthesis of novel (2R,4R)- and (2S,4S)-iso dideoxynucleosides with exocyclic methylene as potential antiviral agents.

PubMed

Yoo, Su Jeong; Kim, Hea Ok; Lim, Yoongho; Kim, Jeongmin; Jeong, Lak Shin

2002-01-01

Novel (2R,4R)- and (2S,4S)-iso dideoxynucleosides with exocyclic methylene have been designed and synthesized, based on the lead BMS-200475 (3) which exhibited potent anti-HBV activity. For the synthesis of D types of (2R,4R)-nucleosides, L-xylose was converted to the key intermediate 14. The intermediate 14 was converted to the uracil derivative 4a and the cytosine derivative 4b. Compound 14 was also converted to the purine derivatives such as adenine derivative 4c, hypoxanthine derivative 4d, and guanine derivative 4e. The corresponding L types of (2S,4S)-enantiomers were more efficiently synthesized from the commercially available 1,2-isopropylidene-D-xylose (20) than the synthetic method used in the synthesis of (2R,4R)-nucleosides. The key intermediate 25 was converted to the pyrimidine analogues 5a and 5b and the purine derivatives 5c, 5d, and 5e using the similar method used in the preparation of 4c, 4d, and 4e. The synthesized final (2R,4R)- and (2S,4S)-nucleosides were tested against several viruses such as HIV-1, HSV-1, HSV-2, HCMV and HBV. (2R,4R)-Adenine analogue 4c exhibited potent anti-HBV activity (EC(50)=1.5 microM in 2.2.15 cells) among compounds tested, while (2R,4R)-uracil derivative 4a was the most active against HCMV among compounds tested and (2R,4R)-adenine derivative 4c was found to be moderately active against the same virus. However, the corresponding (2S,4S)-isomers were found to be totally inactive against all tested viruses. Both (2R,4R)-adenine derivative 4c and (2S,4S)-adenine analogue 5c were totally resistant to the adenosine deaminase like iso-ddA (1). From the molecular modeling study the hydroxymethyl side chains of BMS-200475 (3) and 4c were almost overlapped, indicating that 4c may be suitable for phosphorylation by cellular kinases like the lead 3, but some discrepancy between two bases was observed, indicating why 4c is less potent against HBV than 3. It is concluded that discovery of (2R,4R)-adenine analogue 4c as potent

Structural interactions between lipids, water and S1-S4 voltage-sensing domains.

PubMed

Krepkiy, Dmitriy; Gawrisch, Klaus; Swartz, Kenton J

2012-11-02

Membrane proteins serve crucial signaling and transport functions, yet relatively little is known about their structures in membrane environments or how lipids interact with these proteins. For voltage-activated ion channels, X-ray structures suggest that the mobile voltage-sensing S4 helix would be exposed to the membrane, and functional studies reveal that lipid modification can profoundly alter channel activity. Here, we use solid-state NMR to investigate structural interactions of lipids and water with S1-S4 voltage-sensing domains and to explore whether lipids influence the structure of the protein. Our results demonstrate that S1-S4 domains exhibit extensive interactions with lipids and that these domains are heavily hydrated when embedded in a membrane. We also find evidence for preferential interactions of anionic lipids with S1-S4 domains and that these interactions have lifetimes on the timescale of ≤ 10(-3)s. Arg residues within S1-S4 domains are well hydrated and are positioned in close proximity to lipids, exhibiting local interactions with both lipid headgroups and acyl chains. Comparative studies with a positively charged lipid lacking a phosphodiester group reveal that this lipid modification has only modest effects on the structure and hydration of S1-S4 domains. Taken together, our results demonstrate that Arg residues in S1-S4 voltage-sensing domains reside in close proximity to the hydrophobic interior of the membrane yet are well hydrated, a requirement for carrying charge and driving protein motions in response to changes in membrane voltage. Published by Elsevier Ltd.

Structural interactions between lipids, water and S1-S4 voltage-sensing domains

PubMed Central

Krepkiy, Dmitriy; Gawrisch, Klaus; Swartz, Kenton J.

2012-01-01

Membrane proteins serve crucial signaling and transport functions, yet relatively little is known about their structures in membrane environments or how lipids interact with these proteins. For voltage-activated ion channels, X-ray structures suggest that the mobile voltage-sensing S4 helix would be exposed to the membrane, and functional studies reveal that lipid modification can profoundly alter channel activity. Here we use solid-state NMR to investigate structural interactions of lipids and water with S1-S4 voltage-sensing domains, and to explore whether lipids influence the structure of the protein. Our results demonstrate that S1-S4 domains exhibit extensive interactions with lipids, and that these domains are heavily hydrated when embedded in a membrane. We also find evidence for preferential interactions of anionic lipids with S1-S4 domains, and that these interactions have lifetimes on the timescale of 10−3s. Arg residues within S1-S4 domains are well-hydrated and are positioned in close proximity to lipids, exhibiting local interactions with both lipid head groups and acyl chains. Comparative studies with a positively charged lipid lacking a phosphodiester group reveal that this lipid modification has only modest effects on the structure and hydration of S1-S4 domains. Taken together, our results demonstrate that Arg residues in S1-S4 voltage-sensing domains reside in close proximity to the hydrophobic interior of the membrane, yet are well-hydrated, a requirement for carrying charge and driving protein motions in response to changes in membrane voltage. PMID:22858867

CMB-S4 Technology Book, First Edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abitbol, Maximilian H.

CMB-S4 is a proposed experiment to map the polarization of the Cosmic Microwave Background (CMB) to nearly the cosmic variance limit for the angular scales that are accessible from the ground. The science goals and capabilities of CMB-S4 in illuminating cosmic inflation, measuring the sum of neutrino masses, searching for relativistic relics in the early universe, characterizing dark energy and dark matter, and mapping the matter distribution in the universe have been described in the CMB-S4 Science Book. This Technology Book is a companion volume to the Science Book. The ambitious science goals of the proposed "Stage-IV" CMB-S4 will requiremore » a step forward in experimental capability from the current Stage-III experiments. To guide this process, the community summarized the current state of the technology and identify R&D efforts necessary to advance it for possible use in CMB-S4. The book focused on the technical challenges in four broad areas: Telescope Design; Receiver Optics; Focal-Plane Optical Coupling; and Focal-Plane Sensor and Readout.« less

Fundamentally updating fundamentals.

PubMed

Armstrong, Gail; Barton, Amy

2013-01-01

Recent educational research indicates that the six competencies of the Quality and Safety Education for Nurses initiative are best introduced in early prelicensure clinical courses. Content specific to quality and safety has traditionally been covered in senior level courses. This article illustrates an effective approach to using quality and safety as an organizing framework for any prelicensure fundamentals of nursing course. Providing prelicensure students a strong foundation in quality and safety in an introductory clinical course facilitates early adoption of quality and safety competencies as core practice values. Copyright © 2013 Elsevier Inc. All rights reserved.

Lessons in the Design and Characterization Testing of the Semi-Span Super-Sonic Transport (S4T) Wind-Tunnel Model

NASA Technical Reports Server (NTRS)

2012-01-01

This paper focuses on some of the more challenging design processes and characterization tests of the Semi-Span Super-Sonic Transport (S4T)-Active Controls Testbed (ACT). The model was successfully tested in four entries in the National Aeronautics and Space Administration Langley Transonic Dynamics Tunnel to satisfy the goals and objectives of the Fundamental Aeronautics Program Supersonic Project Aero-Propulso-Servo-Elastic effort. Due to the complexity of the S4T-ACT, only a small sample of the technical challenges for designing and characterizing the model will be presented. Specifically, the challenges encountered in designing the model include scaling the Technology Concept Airplane to model scale, designing the model fuselage, aileron actuator, and engine pylons. Characterization tests included full model ground vibration tests, wing stiffness measurements, geometry measurements, proof load testing, and measurement of fuselage static and dynamic properties.

Unified presentation of four fundamental inequalities

NASA Astrophysics Data System (ADS)

Lajzerowicz, Joseph; Lehoucq, Roland; Graner, François

2018-03-01

We suggest an unified presentation to teach fundamental constants to graduate students, by introducing four lower limits to observed phenomena. The reduced Planck constant ℏ is the lowest classically definable action. The inverse of invariant speed, s, is the lowest observable slowness. The Planck time, {t}{{P}}, is the lowest observable time scale. The Boltzmann constant, k, determines the lowest coherent degree of freedom; we recall an Einstein criterion on the fluctuations of small thermal systems and show that it has far-reaching implications, such as demonstrating the relations between critical exponents. Each of these four fundamental limits enters in an inequality, which marks a horizon of the Universe we can perceive. This compact presentation can resolve some difficulties encountered when trying to defining the epistemologic status of these constants, and emphasizes their useful role in shaping our intuitive vision of the Universe.

Treatment for GaSb surfaces using a sulphur blended (NH4)2S/(NH4)2SO4 solution

NASA Astrophysics Data System (ADS)

Murape, D. M.; Eassa, N.; Neethling, J. H.; Betz, R.; Coetsee, E.; Swart, H. C.; Botha, J. R.; Venter, A.

2012-07-01

A sulphur based chemical, [(NH4)2S/(NH4)2SO4] to which S has been added, not previously reported for the treatment of (1 0 0) n-GaSb surfaces, is introduced and benchmarked against the commonly used passivants Na2S·9H2O and (NH4)2S. The surfaces of the treated material were studied by scanning electron microscopy (SEM), Auger electron spectroscopy (AES) and X-ray photoelectron spectroscopy (XPS). It has been found that the native oxides present on the GaSb surface are more effectively removed when treated with ([(NH4)2S/(NH4)2SO4] + S) than with (NH4)2S or Na2S·9H2O, as evidenced by the ratio of the O506 eV to Sb457 eV AES peaks. XPS results reveal that Sb2S3/Sb2S5 "replaces" Sb2O3/Sb2O5, suggesting that sulphur atoms substitute oxygen atoms in Sb2O3/Sb2O5 to form Sbsbnd S. It seems sulphurization only partially removes Ga2O3. Treatment with ([(NH4)2S/(NH4)2SO4] + S) also results in a noteworthy improvement in the current-voltage (I-V) characteristics of Au/n-GaSb Schottky contacts compared to those fabricated on as-received material.

How fundamental are fundamental constants?

NASA Astrophysics Data System (ADS)

Duff, M. J.

2015-01-01

I argue that the laws of physics should be independent of one's choice of units or measuring apparatus. This is the case if they are framed in terms of dimensionless numbers such as the fine structure constant, ?. For example, the standard model of particle physics has 19 such dimensionless parameters whose values all observers can agree on, irrespective of what clock, rulers or scales? they use to measure them. Dimensional constants, on the other hand, such as ?, c, G, e and k ?, are merely human constructs whose number and values differ from one choice of units to the next. In this sense, only dimensionless constants are 'fundamental'. Similarly, the possible time variation of dimensionless fundamental 'constants' of nature is operationally well defined and a legitimate subject of physical enquiry. By contrast, the time variation of dimensional constants such as ? or ? on which a good many (in my opinion, confusing) papers have been written, is a unit-dependent phenomenon on which different observers might disagree depending on their apparatus. All these confusions disappear if one asks only unit-independent questions. We provide a selection of opposing opinions in the literature and respond accordingly.

Microbial Cellulose Utilization: Fundamentals and Biotechnology

PubMed Central

Lynd, Lee R.; Weimer, Paul J.; van Zyl, Willem H.; Pretorius, Isak S.

2002-01-01

Fundamental features of microbial cellulose utilization are examined at successively higher levels of aggregation encompassing the structure and composition of cellulosic biomass, taxonomic diversity, cellulase enzyme systems, molecular biology of cellulase enzymes, physiology of cellulolytic microorganisms, ecological aspects of cellulase-degrading communities, and rate-limiting factors in nature. The methodological basis for studying microbial cellulose utilization is considered relative to quantification of cells and enzymes in the presence of solid substrates as well as apparatus and analysis for cellulose-grown continuous cultures. Quantitative description of cellulose hydrolysis is addressed with respect to adsorption of cellulase enzymes, rates of enzymatic hydrolysis, bioenergetics of microbial cellulose utilization, kinetics of microbial cellulose utilization, and contrasting features compared to soluble substrate kinetics. A biological perspective on processing cellulosic biomass is presented, including features of pretreated substrates and alternative process configurations. Organism development is considered for “consolidated bioprocessing” (CBP), in which the production of cellulolytic enzymes, hydrolysis of biomass, and fermentation of resulting sugars to desired products occur in one step. Two organism development strategies for CBP are examined: (i) improve product yield and tolerance in microorganisms able to utilize cellulose, or (ii) express a heterologous system for cellulose hydrolysis and utilization in microorganisms that exhibit high product yield and tolerance. A concluding discussion identifies unresolved issues pertaining to microbial cellulose utilization, suggests approaches by which such issues might be resolved, and contrasts a microbially oriented cellulose hydrolysis paradigm to the more conventional enzymatically oriented paradigm in both fundamental and applied contexts. PMID:12209002

The TCP4 transcription factor of Arabidopsis blocks cell division in yeast at G1 {yields} S transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aggarwal, Pooja; Padmanabhan, Bhavna; Bhat, Abhay

2011-07-01

Highlights: {yields} TCP4 is a class II TCP transcription factor, that represses cell division in Arabidopsis. {yields} TCP4 expression in yeast retards cell division by blocking G1 {yields} S transition. {yields} Genome-wide expression studies and Western analysis reveals stabilization of cell cycle inhibitor Sic1, as possible mechanism. -- Abstract: The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce differentiation signal, theirmore » exact role on cell cycle has not been studied. Here, we report that TCP4, a class II TCP protein from Arabidopsis that repress cell proliferation in developing leaves, inhibits cell division by blocking G1 {yields} S transition in budding yeast. Cells expressing TCP4 protein with increased transcriptional activity fail to progress beyond G1 phase. By analyzing global transcriptional status of these cells, we show that expression of a number of cell cycle genes is altered. The possible mechanism of G1 {yields} S arrest is discussed.« less

XYFREZ.4 User’s Manual.

DTIC Science & Technology

1987-12-01

F T FILE I MEuSpecial Report 87-26 December 1987 US Army Corps of Engineers Cold Regions Research & Engineering Laboratory XYFREZ.4 User’s manual...Freeze/thaw User’s manual 19. ABSTRACT (Continue on reverse if necessary and identify by block number) - -- Using the program XYFREZ, version 4, one...may simulate two-dimensional conduction of heat, with or without phase change. The mathematical method employed uses finite elements in space and

Conformal invariance and the metrication of the fundamental forces

NASA Astrophysics Data System (ADS)

Mannheim, Philip D.

2016-07-01

We revisit Weyl’s metrication (geometrization) of electromagnetism. We show that by making Weyl’s proposed geometric connection be pure imaginary, not only are we able to metricate electromagnetism, an underlying local conformal invariance makes the geometry be strictly Riemannian and prevents observational gravity from being complex. Via torsion, we achieve an analogous metrication for axial-vector fields. We generalize our procedure to Yang-Mills theories, and achieve a metrication of all the fundamental forces. Only in the gravity sector does our approach differ from the standard picture of fundamental forces, with our approach requiring that standard Einstein gravity be replaced by conformal gravity. We show that quantum conformal gravity is a consistent and unitary quantum gravitational theory, one that, unlike string theory, only requires four spacetime dimensions.

Cross-National Analysis of Islamic Fundamentalism

DTIC Science & Technology

2016-01-20

attitudes, and was fully involved in activities concerning questionnaire design including a new experimental design in the survey, pilot testing, and...possible collaboration with the research design of the panel survey in Tunisia. • Data analysis: Analyses of religious fundamentalism, women’s dress, trust...the Event History Calendar and the best methods to ask about knowledge and experience of past events. The group designed a series of cognitive

Three dimensional flow field measurements of a 4:1 aspect ratio subsonic jet

NASA Technical Reports Server (NTRS)

Morrison, G. L.; Swan, D. H.

1989-01-01

Flow field measurements for a subsonic rectangular cold air jet with an aspect ratio of 4:1 (12.7 x 50.8 mm) at a Mach number of 0.09 and Re of 100,000 have been carried out using a three-dimensional laser Doppler anemometer system. Mean velocity measurements show that the jet width spreads more rapidly along the minor axis than along the major axis. The outward velocities, however, are not significantly different for the two axes, indicating the presence of enhanced mixing along the minor axis. The jet slowly changes from a rectangular jet to a circular jet as the flow progresses downstream.

The influence of fundamental frequency on perceived duration in spectrally comparable sounds

PubMed Central

Aalto, Daniel; Simko, Juraj; Vainio, Martti

2017-01-01

The perceived duration of a sound is affected by its fundamental frequency and intensity: higher sounds are judged to be longer, as are sounds with greater intensity. Since increasing intensity lengthens the perceived duration of the auditory object, and increasing the fundamental frequency increases the sound’s perceived loudness (up to ca. 3 kHz), frequency modulation of duration could be potentially explained by a confounding effect where the primary cause of the modulation would be variations in intensity. Here, a series of experiments are described that were designed to disentangle the contributions of fundamental frequency, intensity, and duration to perceived loudness and duration. In two forced-choice tasks, participants judged duration and intensity differences between two sounds varying simultaneously in intensity, fundamental frequency, fundamental frequency gliding range, and duration. The results suggest that fundamental frequency and intensity each have an impact on duration judgments, while frequency gliding range did not influence the present results. We also demonstrate that the modulation of perceived duration by sound fundamental frequency cannot be fully explained by the confounding relationship between frequency and intensity. PMID:28879063

Higgs varieties and fundamental groups

NASA Astrophysics Data System (ADS)

Bruzzo, Ugo; Graña Otero, Beatriz

2018-06-01

After reviewing some "fundamental group schemes" that can be attached to a variety by means of Tannaka duality, we consider the example of the Higgs fundamental group scheme, surveying its main properties and relations with the other fundamental groups, and giving some examples.

Identification and electrophysiological studies of (4 S,5 S)-5-hydroxy-4-methyl-3-heptanone and 4-methyl-3,5-heptanedione in male lucerne weevils

NASA Astrophysics Data System (ADS)

Unelius, C. R.; Park, K.-C.; McNeill, M.; Wee, S. L.; Bohman, B.; Suckling, D. M.

2013-02-01

An investigation to identify a sex or aggregation pheromone of Sitona discoideus Gyllenhål (Coleoptera: Curculionidae) is presented. Antenna flicking and attraction behaviors evoked by conspecifics of both sexes were recorded in arena bioassays, where attraction of females to males was observed. Air entrainment of both males and females was conducted in separate chambers. Gas chromatographic-mass spectrometric analysis of headspace volatiles revealed that two male-specific compounds, 4-methyl-3,5-heptanedione (major) and (4 S,5 S)-5-hydroxy-4-methyl-3-heptanone (minor), were emitted during the autumnal post-aestivatory flight period. The stereoisomers of the minor component were separated by enantioselective gas chromatography and their absolute configurations assigned by NMR (diastereomers) and the known preference of enantioselective transesterification reactions catalyzed by Candida antarctica lipase B. Electroantennogram and single sensillum recording studies indicate that 4-methyl-3,5-heptanedione as well as all individual stereoisomers of 5-hydroxy-4-methyl-3-heptanone are detected by the antennae of male and female S. discoideus. Further, single sensillum recordings suggest that both sexes of S. discoideus have specialized olfactory receptor neurons (ORNs) for detecting 4-methyl-3,5-heptanedione and different populations of stereoselective ORNs for detecting the stereoisomers of 5-hydroxy-4-methyl-3-heptanone. Some of these stereoselective ORNs appear to be sex-specific in S. discoideus.

Finite element modeling of borehole heat exchanger systems. Part 1. Fundamentals

NASA Astrophysics Data System (ADS)

Diersch, H.-J. G.; Bauer, D.; Heidemann, W.; Rühaak, W.; Schätzl, P.

2011-08-01

Single borehole heat exchanger (BHE) and arrays of BHE are modeled by using the finite element method. The first part of the paper derives the fundamental equations for BHE systems and their finite element representations, where the thermal exchange between the borehole components is modeled via thermal transfer relations. For this purpose improved relationships for thermal resistances and capacities of BHE are introduced. Pipe-to-grout thermal transfer possesses multiple grout points for double U-shape and single U-shape BHE to attain a more accurate modeling. The numerical solution of the final 3D problems is performed via a widely non-sequential (essentially non-iterative) coupling strategy for the BHE and porous medium discretization. Four types of vertical BHE are supported: double U-shape (2U) pipe, single U-shape (1U) pipe, coaxial pipe with annular (CXA) and centred (CXC) inlet. Two computational strategies are used: (1) The analytical BHE method based on Eskilson and Claesson's (1988) solution, (2) numerical BHE method based on Al-Khoury et al.'s (2005) solution. The second part of the paper focusses on BHE meshing aspects, the validation of BHE solutions and practical applications for borehole thermal energy store systems.

Enhancing Cognitive Understanding to Improve Fundamental Movement Skills

ERIC Educational Resources Information Center

Drost, Daniel K.; Todorovich, John R.

2013-01-01

The development of fundamental movement skills in physical education is an important contributor toward children's' lifetime interest and participation in physical activity. Physical education teachers and their curricula follow national and state standards to provide learning experiences and instruction that support the acquisition of…

[Stem Cells in the Brain of Mammals and Human: Fundamental and Applied Aspects].

PubMed

Aleksandrova, M A; Marey, M V

2015-01-01

Brain stem cells represent an extremely intriguing phenomenon. The aim of our review is to present an integrity vision of their role in the brain of mammals and humans, and their clinical perspectives. Over last two decades, investigations of biology of the neural stem cells produced significant changes in general knowledge about the processes of development and functioning of the brain. Researches on the cellular and molecular mechanisms of NSC differentiation and behavior led to new understanding of their involvement in learning and memory. In the regenerative medicine, original therapeutic approaches to neurodegenerative brain diseases have been elaborated due to fundamental achievements in this field. They are based on specific regenerative potential of neural stem cells and progenitor cells, which possess the ability to replace dead cells and express crucially significant biologically active factors that are missing in the pathological brain. For the needs of cell substitution therapy in the neural diseases, adequate methods of maintaining stem cells in culture and their differentiation into different types of neurons and glial cells, have been developed currently. The success of modern cellular technologies has significantly expanded the range of cells used for cell therapy. The near future may bring new perspective and distinct progress in brain cell therapy due to optimizing the cells types most promising for medical needs.

Modified fundamental Airy wave.

PubMed

Seshadri, S R

2014-01-01

The propagation characteristics of the fundamental Airy wave are obtained; the intensity distribution is the same as that for a point electric dipole situated at the origin and oriented normal to the propagation direction. The propagation characteristics of the modified fundamental Airy wave are determined. These characteristics are the same as those for the fundamental Gaussian wave provided that an equivalent waist is identified for the Airy wave. In general, the waves are localized spatially with the peak in the propagation direction.

Thin coatings in packaging: Fundamental and practical aspects

NASA Astrophysics Data System (ADS)

Thorne, N. A.

1996-01-01

A beverage or food can is very much a functionalized product, the overall performance characteristics being achieved by the use of several materials each of which provides a specific property. Schematically, the metal substrate provides the mechanical and barrier properties, whereby the chemical resistance is provided by specific surface treatments to the metal surface and the application of a thin organic coating. Between about 4-15 μm in thickness, this organic coating has a double protective role, as it must protect the substrate from the foodstuff (corrosion) and the foodstuff from the substrate (taste..) over the required shelflife of the product. To give an idea of the industrial importance of this application, over 100 billion beverage cans per year are produced worldwide, each being individually sprayed with a protective organic layer. To perform correctly these coatings need to possess the following characteristics: —ability to be applied in thin, homogeneous layers without macroscopic or microscopic defects, —sufficient adhesion with the substrate and possess considerable interface stability —mechanical properties sufficient to withstand the can forming operations —intrinsic diffusion barrier properties necessary to prevent significant interaction with the substrate —sufficient chemical resistance to withstand any significant modification of the coating structure and hence intrinsic properties induced by the foodstuff Whereas a considerable amount of scientific attention has been applied to ``bulk'' systems, such as the mechanical properties of epoxies used for composite materials, diffusion in polymer packaging..., little published work is available concerning the specific properties of these thin coatings. The task is not helped by the commercial nature of the resin formulations used, the need to adapt these formulations to the multitude of industrial operations and the physical size of the coatings. The above coating properties will be

Étude vibrationnelle du 3,4'-bitriazole et de quelques-uns de ses dérivés C-monosubstitués

NASA Astrophysics Data System (ADS)

Ouijja, N.; Guédira, F.; Zaydoun, S.; Aouial, M.; Saidi Idrissi, M.; Lautié, A.

1999-05-01

The vibrational study of 3,4'-bitriazole, 5-methyl-3,4'-bitriazole and 5-bromo-3,4'- bitriazole is reported and an assignment of their fundamentals is proposed on the basis of the existence of only one form in the solid state. The substitution of the hydrogen in 3 position of the \\{1H\\} triazolic ring by 4-triazolyl group induces a decrease in the strength of the NH...N hydrogen bond comparatively to 1,2,4-triazole and its C-monosubstituted derivatives. The introduction of a substituent in position 5 of the biheterocycle increases the strength of the self association mainly when the substituent is an electron-attractor group. Using the νN-H wave number values, the estimation of N...N distances in these derivatives is possible. The distinction between the triazolic ring' s vibrations and those of 4-triazolyl group seems impossible, probably because of the conjugation of the two rings. The higher frequency value obtained for the intercyclic bond stretching mode in the BrbTA is explained by an important conjugation and a shorter C-N bond in this case. L'étude vibrationnelle des 3,4'-bitriazole, 5-méthyl-3,4'-bitriazole et 5-bromo-3,4'- bitriazole a été effectuée et une attribution de leurs vibrations fondamentales a été proposée sur la base de l'existence d'une seule forme à l'état solide. La substitution de l'hydrogène en position 3 du cycle triazolique \\{1H\\} par un groupement 4-triazolyle entraîne une diminution de la force de la liaison hydrogène NH...N comparativement au 1,2,4-triazole et à ses dérivés C-monosubstitués. L'introduction d'un substituant en position 5 du bihétérocycle augmente la force de l'autoassociation surtout dans le cas où le substituant est un groupement attracteur d'électrons. A partir des fréquences νNH, l'estimation des distances N...N dans ces dérivés a été effectuée. La distinction entre les vibrations du cycle triazolique et celles du groupement 4-triazolyle semble impossible, probablement à cause de la

32 CFR 274.4 - U.S. guaranty.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false U.S. guaranty. 274.4 Section 274.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

32 CFR 274.4 - U.S. guaranty.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false U.S. guaranty. 274.4 Section 274.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS REGULATIONS GOVERNING COMPETITIVE BIDDING ON U.S. GOVERNMENT GUARANTEED MILITARY EXPORT LOAN AGREEMENTS § 274...

ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo.

PubMed

Beilschmidt, Lena Kristina; Ollagnier de Choudens, Sandrine; Fournier, Marjorie; Sanakis, Ioannis; Hograindleur, Marc-André; Clémancey, Martin; Blondin, Geneviève; Schmucker, Stéphane; Eisenmann, Aurélie; Weiss, Amélie; Koebel, Pascale; Messaddeq, Nadia; Puccio, Hélène; Martelli, Alain

2017-05-11

Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron-sulfur cluster (Fe-S) biogenesis. Recently, it was shown that ISCA1 and ISCA2 form a heterocomplex that is implicated in the maturation of mitochondrial Fe 4 S 4 proteins. Here we report that mouse ISCA1 and ISCA2 are Fe 2 S 2 -containing proteins that combine all features of Fe-S carrier proteins. We use biochemical, spectroscopic and in vivo approaches to demonstrate that despite forming a complex, ISCA1 and ISCA2 establish discrete interactions with components of the late Fe-S machinery. Surprisingly, knockdown experiments in mouse skeletal muscle and in primary cultures of neurons suggest that ISCA1, but not ISCA2, is required for mitochondrial Fe 4 S 4 proteins biogenesis. Collectively, our data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1-ISCA2 complex seem to exist.

ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo

PubMed Central

Beilschmidt, Lena Kristina; Ollagnier de Choudens, Sandrine; Fournier, Marjorie; Sanakis, Ioannis; Hograindleur, Marc-André; Clémancey, Martin; Blondin, Geneviève; Schmucker, Stéphane; Eisenmann, Aurélie; Weiss, Amélie; Koebel, Pascale; Messaddeq, Nadia; Puccio, Hélène; Martelli, Alain

2017-01-01

Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron–sulfur cluster (Fe–S) biogenesis. Recently, it was shown that ISCA1 and ISCA2 form a heterocomplex that is implicated in the maturation of mitochondrial Fe4S4 proteins. Here we report that mouse ISCA1 and ISCA2 are Fe2S2-containing proteins that combine all features of Fe–S carrier proteins. We use biochemical, spectroscopic and in vivo approaches to demonstrate that despite forming a complex, ISCA1 and ISCA2 establish discrete interactions with components of the late Fe–S machinery. Surprisingly, knockdown experiments in mouse skeletal muscle and in primary cultures of neurons suggest that ISCA1, but not ISCA2, is required for mitochondrial Fe4S4 proteins biogenesis. Collectively, our data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1–ISCA2 complex seem to exist. PMID:28492233

Fundamental Studies of Crystal Growth of Microporous Materials

NASA Technical Reports Server (NTRS)

Dutta, P.; George, M.; Ramachandran, N.; Schoeman, B.; Curreri, Peter A. (Technical Monitor)

2002-01-01

Microporous materials are framework structures with well-defined porosity, often of molecular dimensions. Zeolites contain aluminum and silicon atoms in their framework and are the most extensively studied amongst all microporous materials. Framework structures with P, Ga, Fe, Co, Zn, B, Ti and a host of other elements have also been made. Typical synthesis of microporous materials involve mixing the framework elements (or compounds, thereof) in a basic solution, followed by aging in some cases and then heating at elevated temperatures. This process is termed hydrothermal synthesis, and involves complex chemical and physical changes. Because of a limited understanding of this process, most synthesis advancements happen by a trial and error approach. There is considerable interest in understanding the synthesis process at a molecular level with the expectation that eventually new framework structures will be built by design. The basic issues in the microporous materials crystallization process include: (1) Nature of the molecular units responsible for the crystal nuclei formation; (2) Nature of the nuclei and nucleation process; (3) Growth process of the nuclei into crystal; (4) Morphological control and size of the resulting crystal; (5) Surface structure of the resulting crystals; (6) Transformation of frameworks into other frameworks or condensed structures. The NASA-funded research described in this report focuses to varying degrees on all of the above issues and has been described in several publications. Following is the presentation of the highlights of our current research program. The report is divided into five sections: (1) Fundamental aspects of the crystal growth process; (2) Morphological and Surface properties of crystals; (3) Crystal dissolution and transformations; (4) Modeling of Crystal Growth; (5) Relevant Microgravity Experiments.

Proceedings of the Fourth Social Aspects and Recreation Research Symposium: February 4-6, 2004, San Francisco, California

Treesearch

Patrick T. Tierney; Deborah J. (Tech. coords.) Chavez

2004-01-01

The Fourth Social Aspects and Recreation Research (SARR) Symposium was held February 4-6, 2004 in San Francisco, California at the Presidio of San Francisco, a component of Golden Gate National Recreation Area and at San Francisco State University. The theme was: Linking People to the Outdoors: Connections for Healthy Lands, People and Communities.

Modeling and optimization aspects of radiation induced grafting of 4-vinylpyridene onto partially fluorinated films

NASA Astrophysics Data System (ADS)

Nasef, Mohamed Mahmoud; Ahmad Ali, Amgad; Saidi, Hamdani; Ahmad, Arshad

2014-01-01

Modeling and optimization aspects of radiation induced grafting (RIG) of 4-vinylpyridine (4-VP) onto partially fluorinated polymers such as poly(ethylene-co-tetrafluoroethene) (ETFE) and poly(vinylidene fluoride) (PVDF) films were comparatively investigated using response surface method (RSM). The effects of independent parameters: absorbed dose, monomer concentration, grafting time and reaction temperature on the response, grafting yield (GY) were correlated through two quadratic models. The results of this work confirm that RSM is a reliable tool not only for optimization of the reaction parameters and prediction of GY in RIG processes, but also for the reduction of the number of the experiments, monomer consumption and absorbed dose leading to an improvement of the overall reaction cost.

Overlay accuracy fundamentals

NASA Astrophysics Data System (ADS)

Kandel, Daniel; Levinski, Vladimir; Sapiens, Noam; Cohen, Guy; Amit, Eran; Klein, Dana; Vakshtein, Irina

2012-03-01

Currently, the performance of overlay metrology is evaluated mainly based on random error contributions such as precision and TIS variability. With the expected shrinkage of the overlay metrology budget to < 0.5nm, it becomes crucial to include also systematic error contributions which affect the accuracy of the metrology. Here we discuss fundamental aspects of overlay accuracy and a methodology to improve accuracy significantly. We identify overlay mark imperfections and their interaction with the metrology technology, as the main source of overlay inaccuracy. The most important type of mark imperfection is mark asymmetry. Overlay mark asymmetry leads to a geometrical ambiguity in the definition of overlay, which can be ~1nm or less. It is shown theoretically and in simulations that the metrology may enhance the effect of overlay mark asymmetry significantly and lead to metrology inaccuracy ~10nm, much larger than the geometrical ambiguity. The analysis is carried out for two different overlay metrology technologies: Imaging overlay and DBO (1st order diffraction based overlay). It is demonstrated that the sensitivity of DBO to overlay mark asymmetry is larger than the sensitivity of imaging overlay. Finally, we show that a recently developed measurement quality metric serves as a valuable tool for improving overlay metrology accuracy. Simulation results demonstrate that the accuracy of imaging overlay can be improved significantly by recipe setup optimized using the quality metric. We conclude that imaging overlay metrology, complemented by appropriate use of measurement quality metric, results in optimal overlay accuracy.

Statistical competencies for medical research learners: What is fundamental?

PubMed

Enders, Felicity T; Lindsell, Christopher J; Welty, Leah J; Benn, Emma K T; Perkins, Susan M; Mayo, Matthew S; Rahbar, Mohammad H; Kidwell, Kelley M; Thurston, Sally W; Spratt, Heidi; Grambow, Steven C; Larson, Joseph; Carter, Rickey E; Pollock, Brad H; Oster, Robert A

2017-06-01

It is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research. Statistical competency can range from 'fundamental' (necessary for all) to 'specialized' (necessary for only some). In this study, we determine the degree to which each competency is fundamental or specialized. We surveyed members of 4 professional organizations, targeting doctorally trained biostatisticians and epidemiologists who taught statistics to medical research learners in the past 5 years. Respondents rated 24 educational competencies on a 5-point Likert scale anchored by 'fundamental' and 'specialized.' There were 112 responses. Nineteen of 24 competencies were fundamental. The competencies considered most fundamental were assessing sources of bias and variation (95%), recognizing one's own limits with regard to statistics (93%), identifying the strengths, and limitations of study designs (93%). The least endorsed items were meta-analysis (34%) and stopping rules (18%). We have identified the statistical competencies needed by all medical researchers. These competencies should be considered when designing statistical curricula for medical researchers and should inform which topics are taught in graduate programs and evidence-based medicine courses where learners need to read and understand the medical research literature.

S3/S4 Integrated Truss being moved into the Space Shuttle Payloa

NASA Image and Video Library

2007-02-07

In the Space Station Processing Facility, an overhead crane moves the S3/S4 integrated truss to a payload canister. After it is stowed in the canister, the S3/S4 truss will be transported to the launch pad. The truss is the payload on mission STS-117, targeted for launch on March 15.

S3/S4 Integrated Truss being moved into the Space Shuttle Payloa

NASA Image and Video Library

2007-02-07

In the Space Station Processing Facility, an overhead crane settles the S3/S4 integrated truss into the payload canister. After it is stowed in the canister, the S3/S4 truss will be transported to the launch pad. The truss is the payload on mission STS-117, targeted for launch on March 15.

Systematic Sensor Selection Strategy (S4) User Guide

NASA Technical Reports Server (NTRS)

Sowers, T. Shane

2012-01-01

This paper describes a User Guide for the Systematic Sensor Selection Strategy (S4). S4 was developed to optimally select a sensor suite from a larger pool of candidate sensors based on their performance in a diagnostic system. For aerospace systems, selecting the proper sensors is important for ensuring adequate measurement coverage to satisfy operational, maintenance, performance, and system diagnostic criteria. S4 optimizes the selection of sensors based on the system fault diagnostic approach while taking conflicting objectives such as cost, weight and reliability into consideration. S4 can be described as a general architecture structured to accommodate application-specific components and requirements. It performs combinational optimization with a user defined merit or cost function to identify optimum or near-optimum sensor suite solutions. The S4 User Guide describes the sensor selection procedure and presents an example problem using an open source turbofan engine simulation to demonstrate its application.

S3/S4 Integrated Truss being moved into the Space Shuttle Payloa

NASA Image and Video Library

2007-02-07

In the Space Station Processing Facility, an overhead crane lowers the S3/S4 integrated truss into the open bay of the payload canister. After it is stowed in the canister, the S3/S4 truss will be transported to the launch pad. The truss is the payload on mission STS-117, targeted for launch on March 15.

S3/S4 Integrated Truss being moved into the Space Shuttle Payloa

NASA Image and Video Library

2007-02-07

In the Space Station Processing Facility, an overhead crane lowers the S3/S4 integrated truss toward the open doors of the payload canister. After it is stowed in the canister, the S3/S4 truss will be transported to the launch pad. The truss is the payload on mission STS-117, targeted for launch on March 15.

S3/S4 Integrated Truss being moved into the Space Shuttle Payloa

NASA Image and Video Library

2007-02-07

In the Space Station Processing Facility, workers attach an overhead crane to the S3/S4 integrated truss in order to move it to the payload canister. After it is stowed in the canister, the S3/S4 truss will be transported to the launch pad. The truss is the payload on mission STS-117, targeted for launch on March 15.

Role of the S4-S5 linker in CNG channel activation.

PubMed

Kusch, Jana; Zimmer, Thomas; Holschuh, Jascha; Biskup, Christoph; Schulz, Eckhard; Nache, Vasilica; Benndorf, Klaus

2010-10-20

Cyclic nucleotide-gated (CNG) channels mediate sensory signal transduction in retinal and olfactory cells. The channels are activated by the binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus that is located at the intracellular side. The molecular events translating the ligand binding to the pore opening are still unknown. We investigated the role of the S4-S5 linker in the activation process by quantifying its interaction with other intracellular regions. To this end, we constructed chimeric channels in which the N-terminus, the S4-S5 linker, the C-linker, and the CNBD of the retinal CNGA1 subunit were systematically replaced by the respective regions of the olfactory CNGA2 subunit. Macroscopic concentration-response relations were analyzed, yielding the apparent affinity to cGMP and the Hill coefficient. The degree of functional coupling of intracellular regions in the activation gating was determined by thermodynamic double-mutant cycle analysis. We observed that all four intracellular regions, including the relatively short S4-S5 linker, are involved in controlling the apparent affinity of the channel to cGMP and, moreover, in determining the degree of cooperativity between the subunits, as derived from the Hill coefficient. The interaction energies reveal an interaction of the S4-S5 linker with both the N-terminus and the C-linker, but no interaction with the CNBD. Copyright © 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Influential aspects of leader’s Bourdieu capitals on Malaysian landscape architecture subordinates’ creativity

NASA Astrophysics Data System (ADS)

Zahari, R.; Ariffin, M. H.; Othman, N.

2018-02-01

Free Trade Agreements as implemented by Malaysian government calls out local businesses such as landscape architecture consultant firm to explore internationally and strengthen their performance to compete locally. Performance of landscape architecture firm as a design firm depends entirely on creativity of the subordinates in the firm. Past research has neglected studying the influence of a leader’s capitals on subordinates’ creativity, especially in Malaysian landscape architecture firms. The aim of this research is to investigate the influence of subordinates’ perceptions of the leader’s Bourdieu capitals towards promoting subordinate’s creative behaviours in Malaysian Landscape Architecture firms. The sample chosen for this research are subordinates in registered landscape architecture firm. Data was collected using qualitative semi-structured interviews with 13 respondents and analysed using Qualitative Category Coding. Aspects of the leader’s social capital (i.e. knowledge acquisition, problem solving, motivation boosting), human capital (guidance, demotivating leadership, experiential knowledge, knowledge acquisition), and emotional capital (chemistry with leader, respect, knowledge acquisition, trust, understanding, self-inflicted demotivation) that influence subordinates’ creativity were uncovered from the data. The main finding is that the leader’s capitals promote the subordinate landscape architects or assistant landscape architect to be more creative based on three main things, first is knowledge acquisition, motivation, and ability for the leader to influence through positive relationship. The finding contributes to a new way of understanding the leader’s characteristics that influence subordinates’ creativity.

Solar-System Bodies as Teaching Tools in Fundamental Physics

NASA Astrophysics Data System (ADS)

Genus, Amelia; Overduin, James

2018-01-01

We show how asteroids can be used as teaching tools in fundamental physics. Current gravitational theory assumes that all bodies fall with the same acceleration in the same gravitational field. But this assumption, known as the Equivalence Principle, is violated to some degree in nearly all theories that attempt to unify gravitation with the other fundamental forces of nature. In such theories, bodies with different compositions can fall at different rates, producing small non-Keplerian distortions in their orbits. We focus on the unique all-metal asteroid 16 Psyche as a test case. Using Kepler’s laws of planetary motion together with recent observational data on the orbital motions of Psyche and its neighbors, students are able to derive new constraints on current theories in fundamental physics. These constraints take on particular interest since NASA has just announced plans to visit Psyche in 2026.

Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system

PubMed Central

2014-01-01

Background Neurotrophin-4 (NT-4) and brain derived neurotrophic factor (BDNF) bind to the same receptor, Ntrk2/TrkB, but play distinct roles in the development of the rodent gustatory system. However, the mechanisms underlying these processes are lacking. Results Here, we demonstrate, in vivo, that single or combined point mutations in major adaptor protein docking sites on TrkB receptor affect specific aspects of the mouse gustatory development, known to be dependent on BDNF or NT-4. In particular, mice with a mutation in the TrkB-SHC docking site had reduced gustatory neuron survival at both early and later stages of development, when survival is dependent on NT-4 and BDNF, respectively. In addition, lingual innervation and taste bud morphology, both BDNF-dependent functions, were altered in these mutants. In contrast, mutation of the TrkB-PLCγ docking site alone did not affect gustatory neuron survival. Moreover, innervation to the tongue was delayed in these mutants and taste receptor expression was altered. Conclusions We have genetically dissected pathways activated downstream of the TrkB receptor that are required for specific aspects of the taste system controlled by the two neurotrophins NT-4 and BDNF. In addition, our results indicate that TrkB also regulate the expression of specific taste receptors by distinct signalling pathways. These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment. PMID:25256039

CODATA Fundamental Physical Constants

National Institute of Standards and Technology Data Gateway

SRD 121 NIST CODATA Fundamental Physical Constants (Web, free access)   This site, developed in the Physics Laboratory at NIST, addresses three topics: fundamental physical constants, the International System of Units (SI), which is the modern metric system, and expressing the uncertainty of measurement results.

Fundamentals of Library Automation and Technology. Participant Workbook.

ERIC Educational Resources Information Center

Bridge, Frank; Walton, Robert

This workbook presents outlines of topics to be covered during a two-day workshop on the fundamentals for library automation. Topics for the first day include: (1) Introduction; (2) Computer Technology--A Historical Overview; (3) Evolution of Library Automation; (4) Computer Hardware Technology--An Introduction; (5) Computer Software…

The TCP4 transcription factor of Arabidopsis blocks cell division in yeast at G1→S transition.

PubMed

Aggarwal, Pooja; Padmanabhan, Bhavna; Bhat, Abhay; Sarvepalli, Kavitha; Sadhale, Parag P; Nath, Utpal

2011-07-01

The TCP transcription factors control important aspects of plant development. Members of class I TCP proteins promote cell cycle by regulating genes directly involved in cell proliferation. In contrast, members of class II TCP proteins repress cell division. While it has been postulated that class II proteins induce differentiation signal, their exact role on cell cycle has not been studied. Here, we report that TCP4, a class II TCP protein from Arabidopsis that repress cell proliferation in developing leaves, inhibits cell division by blocking G1→S transition in budding yeast. Cells expressing TCP4 protein with increased transcriptional activity fail to progress beyond G1 phase. By analyzing global transcriptional status of these cells, we show that expression of a number of cell cycle genes is altered. The possible mechanism of G1→S arrest is discussed. Copyright © 2011 Elsevier Inc. All rights reserved.

Finite-action solutions of Yang-Mills equations on de Sitter dS4 and anti-de Sitter AdS4 spaces

NASA Astrophysics Data System (ADS)

Ivanova, Tatiana A.; Lechtenfeld, Olaf; Popov, Alexander D.

2017-11-01

We consider pure SU(2) Yang-Mills theory on four-dimensional de Sitter dS4 and anti-de Sitter AdS4 spaces and construct various solutions to the Yang-Mills equations. On de Sitter space we reduce the Yang-Mills equations via an SU(2)-equivariant ansatz to Newtonian mechanics of a particle moving in R^3 under the influence of a quartic potential. Then we describe magnetic and electric-magnetic solutions, both Abelian and non-Abelian, all having finite energy and finite action. A similar reduction on anti-de Sitter space also yields Yang-Mills solutions with finite energy and action. We propose a lower bound for the action on both backgrounds. Employing another metric on AdS4, the SU(2) Yang-Mills equations are reduced to an analytic continuation of the above particle mechanics from R^3 to R^{2,1} . We discuss analytical solutions to these equations, which produce infinite-action configurations. After a Euclidean continuation of dS4 and AdS4 we also present self-dual (instanton-type) Yang-Mills solutions on these backgrounds.

Health aspects of Arctic exploration – Alaska’s medical history based on the research files of Dr. Robert Fortuine

PubMed Central

Murray, Kathleen

2013-01-01

Background Robert Fortuine provided basic medical care to Alaska Native people, chronicled the Health Aspects of Arctic Exploration and through a number of influential publications, was the first to thoroughly document and analyse Alaska’s Medical History. This overview of his published work will provide the reader with a detailed overview, so that they can begin to explore Dr. Fortuine’s many published works in more detail. Objective This review will explore Alaska’s Medical History and the Health Aspects of Arctic Exploration through the research files and the 10 most significant publications of Dr. Robert Fortuine. Design Review of Dr. Fortuine’s major works and the master bibliography has over 3,000 references and 81 subjects. The master bibliography is a merger of 55 separate bibliographies, which provides a wealth of bibliographic information. This paper will describe his 10 most significant publications, 2 of which began as a journal issue. Results Dr. Fortuine was a prolific writer throughout his career, publishing 134 articles and books. He wrote papers and books on Alaska’s medical history, tuberculosis and health care delivery from Russian–America through the Public Health Service efforts in the territory and then the State of Alaska. The master bibliography has over 3,000 references and 81 subjects. This list has a significant number of entries for tuberculosis with almost one-third of the entries including this heading. Others dwell on the history of “pre-contact” health, the history of Alaska Native health care, the history of the Alaska Department of Health, especially the tuberculosis programme, the role of the US Public Health Service and traditional medicine. He completely reviewed every Governors’ and the US Surgeon General’s reports in regard to Alaska content. This paper describes his 10 most significant publications. Conclusions Robert Fortuine’s published works offer a wealth of information and insight into Alaska’s

EPA’s SPECIATE 4.4 Database: Bridging Data Sources and Data Users

EPA Science Inventory

SPECIATE is the U.S. Environmental Protection Agency's (EPA)repository of volatile organic gas and particulate matter (PM) speciation profiles for air pollution sources. EPA released SPECIATE 4.4 in early 2014 and, in total, the SPECIATE 4.4 database includes 5,728 PM, VOC, total...

High-resolution synchrotron infrared spectroscopy of thiophosgene: The ν2 and ν4 fundamental bands near 500 cm -1

NASA Astrophysics Data System (ADS)

McKellar, A. R. W.; Billinghurst, B. E.

2010-03-01

Thiophosgene (Cl 2CS) is a favorite model system for studies of photophysics, vibrational dynamics, and intersystem interaction effects. But there are no previous rotationally-resolved infrared studies because the spectra are very congested due to hot bands and multiple isotopic species. This paper reports a detailed study of the ν2 (˜504 cm -1) and ν4 (˜471 cm -1) fundamental bands for the two most abundant isotopomers, 35Cl 2CS and 35Cl 37ClCS, based on spectra with observed line widths of ˜0.0008 cm -1 obtained at the Canadian Light Source far-infrared beamline using synchrotron radiation and a Bruker IFS125 Fourier transform spectrometer.

Computational chemistry of modified [MFe3S4] and [M2Fe2S4] clusters: assessment of trends in electronic structure and properties.

PubMed

Jensen, Kasper P; Ooi, Bee-Lean; Christensen, Hans E M

2008-12-18

The aim of this work is to understand the molecular evolution of iron-sulfur clusters in terms of electronic structure and function. Metal-substituted models of biological [Fe(4)S(4)] clusters in oxidation states [M(x)Fe(4-x)S(4)](3+/2+/1+) have been studied by density functional theory (M = Cr, Mn, Fe, Co, Ni, Cu, Zn, and Pd, with x = 1 or 2). Most of these clusters have not been characterized before. For those that have been characterized experimentally, very good agreement is obtained, implying that also the predicted structures and properties of new clusters are accurate. Mean absolute errors are 0.024 A for bond lengths ([Fe(4)S(4)], [NiFe(3)S(4)], [CoFe(3)S(4)]) and 0.09 V for shifts in reduction potentials relative to the [Fe(4)S(4)] cluster. All structures form cuboidal geometries similar to the all-iron clusters, except the Pd-substituted clusters, which instead form highly distorted trigonal and tetragonal local sites in compromised, pseudocuboidal geometries. In contrast to other electron-transfer sites, cytochromes, blue copper proteins, and smaller iron-sulfur clusters, we find that the [Fe(4)S(4)] clusters are very insensitive to metal substitution, displaying quite small changes in reorganization energies and reduction potentials upon substitution. Thus, the [Fe(4)S(4)] clusters have an evolutionary advantage in being robust to pollution from other metals, still retaining function. We analyze in detail the electronic structure of individual clusters and rationalize spin couplings and redox activity. Often, several configurations are very close in energy, implying possible use as spin-crossover systems, and spin states are predicted accurately in all but one case ([CuFe(3)S(4)]). The results are anticipated to be helpful in defining new molecular systems with catalytic and magnetic properties.

Effects of Traditional Gender Role Norms and Religious Fundamentalism on Self-Identified Heterosexual Men's Attitudes, Anger, and Aggression Toward Gay Men and Lesbians

PubMed Central

Vincent, Wilson; Parrott, Dominic J.; Peterson, John L.

2011-01-01

Sexual prejudice and antigay anger were examined as mediators of the associations between traditional male gender norms, religious fundamentalism, and aggression toward gay men and lesbians. Participants were 201 self-identified heterosexual men recruited from the community to complete computer-administered measures of adherence to traditional male gender norms (i.e., status, toughness, antifemininity), religious fundamentalism, sexual prejudice, and frequency of aggression toward gay men and lesbians. Additionally, participants completed a structured interview designed to assess anger in response to a vignette depicting a male-male intimate relationship (i.e., partners saying “I love you,” holding hands, kissing). Results showed that sexual prejudice and antigay anger partially mediated the effect of antifemininity on aggression and fully mediated the effect of religious fundamentalism on aggression. Sexual prejudice alone fully mediated the effect of status on aggression and neither sexual prejudice nor antigay anger mediated the effect of toughness on aggression. Further, results suggested that religious fundamentalism is a multifaceted construct of which some aspects increase risk for aggression toward gay men and lesbians, whereas other aspects decrease this risk. These data provide multivariate evidence from a nonprobability, community-based sample that extreme internalization of dominant cultural values can set the stage for violence toward marginalized groups. Implications for intervention programming and future research are reviewed. PMID:22081759

The Aspect Hypothesis Revisited: A Cross-Sectional Study of Tense and Aspect Marking in Interlanguage.

ERIC Educational Resources Information Center

Robison, Richard E.

1995-01-01

This article examined the aspect hypothesis, which asserts that verb inflections in early interlanguage systems function primarily as markers of lexical aspect independent of the target language. A study of interviews conducted with 26 Puerto Rican college students grouped into 4 proficiency levels found that the association of inflections with…

Aspects of AdS/CFT: Conformal Deformations and the Goldstone Equivalence Theorem

NASA Astrophysics Data System (ADS)

Cantrell, Sean Andrew

The AdS/CFT correspondence provides a map from the states of theories situated in AdSd+1 to those in dual conformal theories in a d-dimensional space. The correspondence can be used to establish certain universal properties of some theories in one space by examining the behave of general objects in the other. In this thesis, we develop various formal aspects of AdS/CFT. Conformal deformations manifest in the AdS/CFT correspondence as boundary conditions on the AdS field. Heretofore, double-trace deformations have been the primary focus in this context. To better understand multitrace deformations, we revisit the relationship between the generating AdS partition function for a free bulk theory and the boundary CFT partition function subject to arbitrary conformal deformations. The procedure leads us to a formalism that constructs bulk fields from boundary operators. We independently replicate the holographic RG flow narrative to go on to interpret the brane used to regulate the AdS theory as a renormalization scale. The scale-dependence of the dilatation spectrum of a boundary theory in the presence of general deformations can be thus understood on the AdS side using this formalism. The Goldstone equivalence theorem allows one to relate scattering amplitudes of massive gauge fields to those of scalar fields in the limit of large scattering energies. We generalize this theorem under the framework of the AdS/CFT correspondence. First, we obtain an expression of the equivalence theorem in terms of correlation functions of creation and annihilation operators by using an AdS wave function approach to the AdS/CFT dictionary. It is shown that the divergence of the non-conserved conformal current dual to the bulk gauge field is approximately primary when computing correlators for theories in which the masses of all the exchanged particles are sufficiently large. The results are then generalized to higher spin fields. We then go on to generalize the theorem using conformal

Neutrinos, ultra-high-energy cosmic rays and fundamental physics

NASA Astrophysics Data System (ADS)

Ellis, John

2001-05-01

In the first lecture, aspects of neutrino physics beyond the Standard Model are emphasized, including the emerging default options for atmospheric and solar neutrino oscillations, namely νμ-->ντ and νe-->νμ,τ respectively, and the need to check them, the prospects opened up by the successful starts of SNO and K2K and the opportunities for future long-baseline neutrino experiments. In the second lecture, it is discussed how cosmic rays may provide opportunities for probing fundamental physics. For example, ultra-high-energy cosmic rays might originate from the decays of metastable heavy particles, and astrophysical γ rays can be used to test models of quantum gravity. Both scenarios offer ways to avoid the GZK cut-off, and might best be probed using high-energy astrophysical neutrinos. .

Aspects of Quantum Theory

NASA Astrophysics Data System (ADS)

Salam, Abdus; Wigner, E. P.

2010-03-01

Preface; List of contributors; Bibliography of P. A. M. Dirac; 1. Dirac in Cambridge R. J. Eden and J. C. Polkinghorne; 2. Travels with Dirac in the Rockies J. H. Van Vleck; 3. 'The golden age of theoretical physics': P. A. M. Dirac's scientific work from 1924 to 1933 Jagdish Mehra; 4. Foundation of quantum field theory Res Jost; 5. The early history of the theory of electron: 1897-1947 A. Pais; 6. The Dirac equation A. S. Wightman; 7. Fermi-Dirac statistics Rudolph Peierls; 8. Indefinite metric in state space W. Heisenberg; 9. On bras and kets J. M. Jauch; 10. The Poisson bracket C. Lanczos; 11. La 'fonction' et les noyaux L. Schwartz; 12. On the Dirac magnetic poles Edoardo Amadli and Nicola Cabibbo; 13. The fundamental constants and their time variation Freeman J. Dyson; 14. On the time-energy uncertainty relation Eugene P. Wigner; 15. The path-integral quantisation of gravity Abdus Salam and J. Strathdee; Index; Plates.

IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

PubMed Central

Ruscic, Katarina J.; Miceli, Francesco; Villalba-Galea, Carlos A.; Dai, Hui; Mishina, Yukiko; Bezanilla, Francisco; Goldstein, Steve A. N.

2013-01-01

Human IKs channels activate slowly with the onset of cardiac action potentials to repolarize the myocardium. IKs channels are composed of KCNQ1 (Q1) pore-forming subunits that carry S4 voltage-sensor segments and KCNE1 (E1) accessory subunits. Together, Q1 and E1 subunits recapitulate the conductive and kinetic properties of IKs. How E1 modulates Q1 has been unclear. Investigators have variously posited that E1 slows the movement of S4 segments, slows opening and closing of the conduction pore, or modifies both aspects of electromechanical coupling. Here, we show that Q1 gating current can be resolved in the absence of E1, but not in its presence, consistent with slowed movement of the voltage sensor. E1 was directly demonstrated to slow S4 movement with a fluorescent probe on the Q1 voltage sensor. Direct correlation of the kinetics of S4 motion and ionic current indicated that slowing of sensor movement by E1 was both necessary and sufficient to determine the slow-activation time course of IKs. PMID:23359697

Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skraastad, M.I.; Van de Vosse, E.; Belfroid, R.

1992-10-01

Significant linkage disequilibrium has been found between the Huntington disease (HD) gene and DNA markers located around D4S95 and D4S98. The linkage-disequilibrium studies favor the proximal location of the HD gene, in contrast to the conflicting results of recombination analyses. The authors have analyzed 45 Dutch HD families with 19 DNA markers and have calculated the strength of linkage disequilibrium. Highly significant linkage disequilibrium has been detected with D4S95, consistent with the studies in other populations. In contrast with most other studies, however, the area of linkage disequilibrium extends from D4S10 proximally to D4S95, covering 1,100 kb. These results confirmmore » that the HD gene most likely maps near D4S95. 28 refs., 1 fig., 2 tabs.« less

Long-term hepatic outcomes in survivors of stage 4S and 4 neuroblastoma in infancy.

PubMed

French, Amy E; Irwin, Meredith S; Navarro, Oscar M; Greenberg, Mark; Nathan, Paul C

2012-02-01

Infants with stage 4 and 4S neuroblastoma (NB) have a superior prognosis to older children. However, they often require intensive therapy including abdominal radiation. We aimed to investigate the long-term hepatic outcomes in infants with stage 4S and 4 NB. We reviewed the charts of 38 infants diagnosed with stage 4S and 4 NB between 1984 and 2002. We included only those with available follow-up 5 years following diagnosis. We assessed hepatic imaging and function (transaminases, bilirubin, alkaline phosphatase) at all available time points from diagnosis. Abnormalities present at more than 5 years from diagnosis were considered persistent late changes. We identified 15 stage 4S and 12 stage 4 patients. Twelve of 15 stage 4S patients had hepatic involvement at diagnosis, 8 of whom required abdominal radiation. Five of eight demonstrated late imaging changes. Two of four with hepatic metastases but no radiation demonstrated late imaging changes. The late imaging changes resolved over time and without intervention in 3/7 survivors. The persistent lesions included liver fibrosis (1) and focal nodular hyperplasia (FNH) (3). Five of 12 stage 4 NB patients had hepatic involvement at diagnosis; none required radiation or had late hepatic imaging changes. In stage 4S NB, adverse hepatic effects are infrequent, may resolve over time, and occur with or without radiation. FNH should be considered in those with persistent late imaging changes. Adverse hepatic outcomes after liver involvement or radiation in infants with stage 4 NB rarely occur. Copyright © 2011 Wiley Periodicals, Inc.

Fundamental Vibration of Molecular Hydrogen

NASA Astrophysics Data System (ADS)

Dickenson, G. D.; Niu, M. L.; Salumbides, E. J.; Komasa, J.; Eikema, K. S. E.; Pachucki, K.; Ubachs, W.

2013-05-01

The fundamental ground tone vibration of H2, HD, and D2 is determined to an accuracy of 2×10-4cm-1 from Doppler-free laser spectroscopy in the collisionless environment of a molecular beam. This rotationless vibrational splitting is derived from the combination difference between electronic excitation from the X1Σg+, v=0, and v=1 levels to a common EF1Σg+, v=0 level. Agreement within 1σ between the experimental result and a full ab initio calculation provides a stringent test of quantum electrodynamics in a chemically bound system.

Individual differences in fundamental social motives.

PubMed

Neel, Rebecca; Kenrick, Douglas T; White, Andrew Edward; Neuberg, Steven L

2016-06-01

Motivation has long been recognized as an important component of how people both differ from, and are similar to, each other. The current research applies the biologically grounded fundamental social motives framework, which assumes that human motivational systems are functionally shaped to manage the major costs and benefits of social life, to understand individual differences in social motives. Using the Fundamental Social Motives Inventory, we explore the relations among the different fundamental social motives of Self-Protection, Disease Avoidance, Affiliation, Status, Mate Seeking, Mate Retention, and Kin Care; the relationships of the fundamental social motives to other individual difference and personality measures including the Big Five personality traits; the extent to which fundamental social motives are linked to recent life experiences; and the extent to which life history variables (e.g., age, sex, childhood environment) predict individual differences in the fundamental social motives. Results suggest that the fundamental social motives are a powerful lens through which to examine individual differences: They are grounded in theory, have explanatory value beyond that of the Big Five personality traits, and vary meaningfully with a number of life history variables. A fundamental social motives approach provides a generative framework for considering the meaning and implications of individual differences in social motivation. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Dynamics of an [Fe4S4(SPh)4]2- cluster explored via IR, Raman, and nuclear resonance vibrational spectroscopy (NRVS)-analysis using 36S substitution, DFT calculations, and empirical force fields.

PubMed

Xiao, Yuming; Koutmos, Markos; Case, David A; Coucouvanis, Dimitri; Wang, Hongxin; Cramer, Stephen P

2006-05-14

We have used four vibrational spectroscopies--FT-IR, FT-Raman, resonance Raman, and 57Fe nuclear resonance vibrational spectroscopy (NRVS)--to study the normal modes of the Fe-S cluster in [(n-Bu)4N]2[Fe4S4(SPh)4]. This [Fe4S4(SR)4]2- complex serves as a model for the clusters in 4Fe ferredoxins and high-potential iron proteins (HiPIPs). The IR spectra exhibited differences above and below the 243 K phase transition. Significant shifts with 36S substitution into the bridging S positions were also observed. The NRVS results were in good agreement with the low temperature data from the conventional spectroscopies. The NRVS spectra were interpreted by normal mode analysis using optimized Urey-Bradley force fields (UBFF) as well as from DFT theory. For the UBFF calculations, the parameters were refined by comparing calculated and observed NRVS frequencies and intensities. The frequency shifts after 36S substitution were used as an additional constraint. A D 2d symmetry Fe4S4S'4 model could explain most of the observed frequencies, but a better match to the observed intensities was obtained when the ligand aromatic rings were included for a D 2d Fe4S4(SPh)4 model. The best results were obtained using the low temperature structure without symmetry constraints. In addition to stretching and bending vibrations, low frequency modes between approximately 50 and 100 cm(-1) were observed. These modes, which have not been seen before, are interpreted as twisting motions with opposing sides of the cube rotating in opposite directions. In contrast with a recent paper on a related Fe4S4 cluster, we find no need to assign a large fraction of the low frequency NRVS intensity to 'rotational lattice modes'. We also reassign the 430 cm(-1) band as primarily an elongation of the thiophenolate ring, with approximately 10% terminal Fe-S stretch character. This study illustrates the benefits of combining NRVS with conventional Raman and IR analysis for characterization of Fe-S centers. DFT

Fundamental Studies of Jumping-Drop Thermal Diodes

DTIC Science & Technology

2016-02-29

Space Vehicles Directorate Air Force Research Laboratory AFRL /RVSV 3550 Aberdeen Ave SE 11. SPONSOR/MONITOR’S REPORT Kirtland AFB, NM 87117-5776 NUMBER...unlimited. 15 DISTRIBUTION LIST DTIC/OCP 8725 John J. Kingman Rd, Suite 0944 Ft Belvoir, VA 22060-6218 1 cy AFRL /RVIL Kirtland AFB, NM... AFRL -RV-PS- AFRL -RV-PS- TR-2016-0002 TR-2016-0002 FUNDAMENTAL STUDIES OF JUMPING-DROP THERMAL DIODES Chuan-Hua Chen Duke

Welding Fundamentals. U.S.O.E. 17.23 16. Student's Manual [and] Instructor's Guide.

ERIC Educational Resources Information Center

Fulgham, Wayne

This two-part publication covers the fundamentals for the beginning welder. The student's manual includes many illustrations to acquaint the student with tools and materials used in the welding trade. The manual is self-contained and is written for use in all types of trade and industrial classes. The manual contains 10 lessons, each of which…

PREFACE New developments in nanopore research—from fundamentals to applications New developments in nanopore research—from fundamentals to applications

NASA Astrophysics Data System (ADS)

Albrecht, Tim; Edel, Joshua B.; Winterhalter, Mathias

2010-11-01

Biological and solid-state nanopores are an exciting field of research, which has seen a rapid development over the last 10 to 20 years. Activities in this area range from theoretical and experimental work on the underlying fundamental (bio)physics to applications in single-molecule biosensing. And while the prospect of DNA sequencing continues to be a major driving force, other applications with potentially similar impact begin to emerge, for example the detection of small molecules, proteins, protein/protein and protein/DNA complexes, and RNA to name just a few. It has also become apparent that both classes of nanopore devices have intrinsic advantages and disadvantages; hybrid structures combining the better of the two worlds would be a logical consequence and are beginning to appear in the literature. Many other highly innovative ideas and concepts continue to emerge and the number of nanopore-related publications has increased drastically over recent years. We found that more than 100 research groups worldwide are active in this area; several commercial settings are in the process of translating fundamental research into real-life applications. We therefore felt that now is the right time to showcase these new developments in a special issue: to inspire researchers active in the field, to liberate inherent synergies, and not least, to demonstrate to the outside world the current state-of-the-art and future opportunities. The title 'New developments in nanopore research—from fundamentals to applications' in some way reflects these ambitions and, even though not everyone invited was able to contribute, we were able to assemble 34 high-quality research papers from all over the world. We would like to acknowledge and thank all the contributors for their submissions, which made this special issue possible in the first place. Moreover, we would like to thank the staff at IOP Publishing for helping us with the administrative aspects and for coordinating the

A concise review of nanoscopic aspects of bioleaching bacteria-mineral interactions.

PubMed

Diao, Mengxue; Taran, Elena; Mahler, Stephen; Nguyen, Anh V

2014-10-01

Bioleaching is a technology for the recovery of metals from minerals by means of microorganisms, which accelerate the oxidative dissolution of the mineral by regenerating ferric ions. Bioleaching processes take place at the interface of bacteria, sulfide mineral and leaching solution. The fundamental forces between a bioleaching bacterium and mineral surface are central to understanding the intricacies of interfacial phenomena, such as bacterial adhesion or detachment from minerals and the mineral dissolution. This review focuses on the current state of knowledge in the colloidal aspect of bacteria-mineral interactions, particularly for bioleaching bacteria. Special consideration is given to the microscopic structure of bacterial cells and the atomic force microscopy technique used in the quantification of fundamental interaction forces at nanoscale. Copyright © 2014 Elsevier B.V. All rights reserved.

[Bovine herpesvirus 4 (BoHV-4): general aspects of the biology and status in Argentina].

PubMed

Morán, Pedro E; Pérez, Sandra E; Odeón, Anselmo C; Verna, Andrea E

2015-01-01

Bovine herpesvirus 4 (BoHV-4) has been isolated from cattle with respiratory infections, vulvovaginitis, mastitis, abortions, endometritis and from apparently healthy animals throughout the world. Although it has not yet been established as causal agent of a specific disease entity, it is primarily associated with reproductive disorders of cattle. This virus can infect a wide range of species, either in vivo or in vitro. Two groups of prototype strains were originated from the first isolates: the DN599-type strains (American group) and the Movar-type strains (European group). In Argentina, BoHV-4 was isolated and characterized in 2007 from vaginal discharge samples taken from cows that had aborted. So far, more than 40 isolates, mainly associated with aborting bovine females have been registered in our country. Copyright © 2014 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

Legal, ethical and professional aspects of duty of care for nurses.

PubMed

Dowie, Iwan

2017-12-13

Duty of care is a fundamental aspect of nursing, and many nurses consider this to be an important part of their professional duties as a nurse. However, the legal underpinnings of duty of care are often overlooked, and, as such, nurses may be unsure about when to act if they encounter emergency situations or serious incidents, especially when they are off duty. This article examines the legal, ethical and professional aspects of duty of care, what these mean for nurses in practice, and how duty of care is intrinsically linked with standards of care and negligence. ©2017 RCN Publishing Company Ltd. All rights reserved. Not to be copied, transmitted or recorded in any way, in whole or part, without prior permission of the publishers.

Robots in Space -Psychological Aspects

NASA Technical Reports Server (NTRS)

Sipes, Walter E.

2006-01-01

A viewgraph presentation on the psychological aspects of developing robots to perform routine operations associated with monitoring, inspection, maintenance and repair in space is shown. The topics include: 1) Purpose; 2) Vision; 3) Current Robots in Space; 4) Ground Based Robots; 5) AERCam; 6) Rotating Bladder Robot (ROBLR); 7) DART; 8) Robonaut; 9) Full Immersion Telepresence Testbed; 10) ERA; and 11) Psychological Aspects

CFD Assessment of Orifice Aspect Ratio and Mass Flow Ratio on Jet Mixing in Rectangular Ducts

NASA Technical Reports Server (NTRS)

Bain, D. B.; Smith, C. E.; Holdeman, J. D.

1994-01-01

Isothermal CFD analysis was performed on axially opposed rows of jets mixing with cross flow in a rectangular duct. Laterally, the jets' centerlines were aligned with each other on the top and bottom walls. The focus of this study was to characterize the effects of orifice aspect ratio and jet-to-mainstream mass flow ratio on jet penetration and mixing. Orifice aspect ratios (L/W) of 4-to-1, 2-to-1, and 1-to-1, along with circular holes, were parametrically analyzed. Likewise, jet-to-mainstream mass flow ratios (MR) of 2.0, 0.5, and 0.25 were systematically investigated. The jet-to-mainstream momentum-flux ratio (J) was maintained at 36 for all cases, and the orifice spacing-to-duct height (S/H) was varied until optimum mixing was attained for each configuration. The numerical results showed that orifice aspect ratio (and likewise orifice blockage) had little effect on jet penetration and mixing. Based on mixing characteristics alone, the 4-to-1 slot was comparable to the circular orifice. The 4-to-1 slot has a smaller jet wake which may be advantageous for reducing emissions. However, the axial length of a 4-to-1 slot may be prohibitively long for practical application, especially for MR of 2.0. The jet-to-mainstream mass flow ratio had a more significant effect on jet penetration and mixing. For a 4-to-1 aspect ratio orifice, the design correlating parameter for optimum mixing (C = (S/H)(sq. root J)) varied from 2.25 for a mass flow ratio of 2.0 to 1.5 for a mass flow ratio of 0.25.

High Resolution Infrared Studies of the v2, v4 Bands of 34S16O3, Including Both Intensity and Wavenumber Perturbations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barber, Jeffrey B.; Masiello, Tony; Chrysostom, Engelene

2003-06-15

The infrared spectrum of the v2, v4 bending mode region of 34S-substituted sulfur trioxide, 34S16O3, has been recorded at a resolution of 0.0025 cm-1. The v2 and v4 levels are coupled by a Coriolis interaction, yielding significant spectral shifts that have been successfully analyzed to obtain rovibrational constants for the ground state and both fundamentals. Comparisons are made with 32S16O3 parameters and the Bo rotational constant is found to be 0.348 556 04(28) cm-1, only very slightly larger than the corresponding value of 0.348 543 33(5) cm-1 for 32S16O3. Coriolis and l-type resonance interactions between the v2 and v4 levelsmore » produce frequency shifts and strong intensity perturbations in the spectra that are considered for both 34S16O3 and 32S16O3. The resulting analysis yields an average value of+0.62(8) for the dipole derivative ratio (?x/?Q4x) (?z/?Q2) and a positive sign for the product of this ratio with the?y2,4 Coriolis constant, for which experiment gives+0.5940(15) . Ab initio calculations indicate that the signs of?x/?Q4x and?z/?Q2 are both positive and hence?y2,4 is also positive, in agreement with earlier calculations. These signs indicate that the effective charge movement in the xz plane has the same sense of rotation as Q2, Q4x atom motion in this plane that produces a py vibrational angular momentum component, correlated motion that is confirmed by ab initio calculations.« less

Nanomechanics of silk: the fundamentals of a strong, tough and versatile material

NASA Astrophysics Data System (ADS)

Su, Isabelle; Buehler, Markus J.

2016-07-01

Spider silk is a remarkable material that provides a template for upscaling molecular properties to the macroscale. In this article we review fundamental aspects of the mechanisms behind these behaviors, discuss the molecular makeup, chemical designs, and how these integrate in a complex arrangement to form webs, cocoons and other material architectures. Moreover, this review paper explores the unique ability of silk to tolerate various kinds of defects, in a way enabling this material platform to serve as one of the most resilient materials in nature. We conclude the discussion with a summary of key scaling laws, an attempt model and define hierarchical length-scales, and the translation to synthetic materials.

Nanomechanics of silk: the fundamentals of a strong, tough and versatile material.

PubMed

Su, Isabelle; Buehler, Markus J

2016-07-29

Spider silk is a remarkable material that provides a template for upscaling molecular properties to the macroscale. In this article we review fundamental aspects of the mechanisms behind these behaviors, discuss the molecular makeup, chemical designs, and how these integrate in a complex arrangement to form webs, cocoons and other material architectures. Moreover, this review paper explores the unique ability of silk to tolerate various kinds of defects, in a way enabling this material platform to serve as one of the most resilient materials in nature. We conclude the discussion with a summary of key scaling laws, an attempt model and define hierarchical length-scales, and the translation to synthetic materials.

Exploring a new S U (4 ) symmetry of meson interpolators

NASA Astrophysics Data System (ADS)

Glozman, L. Ya.; Pak, M.

2015-07-01

In recent lattice calculations it has been discovered that mesons upon truncation of the quasizero modes of the Dirac operator obey a symmetry larger than the S U (2 )L×S U (2 )R×U (1 )A symmetry of the QCD Lagrangian. This symmetry has been suggested to be S U (4 )⊃S U (2 )L×S U (2 )R×U (1 )A that mixes not only the u- and d-quarks of a given chirality, but also the left- and right-handed components. Here it is demonstrated that bilinear q ¯q interpolating fields of a given spin J ≥1 transform into each other according to irreducible representations of S U (4 ) or, in general, S U (2 NF). This fact together with the coincidence of the correlation functions establishes S U (4 ) as a symmetry of the J ≥1 mesons upon quasizero mode reduction. It is shown that this symmetry is a symmetry of the confining instantaneous charge-charge interaction in QCD. Different subgroups of S U (4 ) as well as the S U (4 ) algebra are explored.

Subversion: The Neglected Aspect of Computer Security.

DTIC Science & Technology

1980-06-01

fundamentally flawed. Recall from mathematics that it is sufficient to disprove a4 proposition (e.g., that a system is secure) by showing only one example where...made. This lack of protection is one of the fundamental reasons why the subversion of computer systems can be so effective. Later chapters will amplify...an area of code that will not be liable to revision. Operatine system software, as pointed out earlier, is often riddled with design errors or subject

Retraction: New aspects of photon propagation in expanding universes

NASA Astrophysics Data System (ADS)

Fahr, H.-J.; Heyl, M.

2017-12-01

According to present cosmological views the energy density of CMB (Cosmic Microwave Background) photons, freely propagating through the expanding cosmos, varies proportional to 1/S^4 with S being the scale factor of the universe. This behavior is expected, because General Theory of Relativity, in application to FLRW- (Friedmann-Lemaitre-Robertson-Walker) cosmological universes, leads to the conclusion that the photon wavelengths increase during their free passage through the spacetime metrics of the universe by the same factor as does the scale factor S. This appears to be a reasonable explanation for the presently observed Planckian CMB spectrum with its actual temperature of about 2.7 K, while at the time of its origin after the last scattering during the recombination phase its temperature should have been about 3000 K, at an epoch of about 380 ky after the Big Bang, when the scale of the universe S_r was smaller by roughly a factor of S/S_r = 1+z_r = 1100 compared to the present scale S = S_0 of the universe. In this paper we start from putting the question whether the scale-behavior of the CMB energy density that enters the energy-momentum tensor of the field equations describing the expanding universe is really falling off like 1/S^4 and, if in fact a deviation from a behavior according to 1/S^4 would occur, why do we nevertheless presently observe a CMB energy density which appears to be in accordance with such a 1/S^4-scaling? This question arises from another basic and fundamental question, namely: Can we really assume that the wavelength of the freely propagating photon during its travel all the way along its light geodetic is permanently affected by the expansion of the universe, i.e continuously recognizes the expansion of the cosmic scale S? With other words: Do freely propagating photons ........

The Fundamental Neutron Physics Beamline at the Spallation Neutron Source.

PubMed

Greene, Geoffrey; Cianciolo, Vince; Koehler, Paul; Allen, Richard; Snow, William Michael; Huffman, Paul; Gould, Chris; Bowman, David; Cooper, Martin; Doyle, John

2005-01-01

The Spallation Neutron Source (SNS), currently under construction at Oak Ridge National Laboratory with an anticipated start-up in early 2006, will provide the most intense pulsed beams of cold neutrons in the world. At a projected power of 1.4 MW, the time averaged fluxes and fluences of the SNS will approach those of high flux reactors. One of the flight paths on the cold, coupled moderator will be devoted to fundamental neutron physics. The fundamental neutron physics beamline is anticipated to include two beam-lines; a broad band cold beam, and a monochromatic beam of 0.89 nm neutrons for ultracold neutron (UCN) experiments. The fundamental neutron physics beamline will be operated as a user facility with experiment selection based on a peer reviewed proposal process. An initial program of five experiments in neutron decay, hadronic weak interaction and time reversal symmetry violation have been proposed.

Electron tomography and fractal aspects of MoS2 and MoS2/Co spheres.

PubMed

Ramos, Manuel; Galindo-Hernández, Félix; Arslan, Ilke; Sanders, Toby; Domínguez, José Manuel

2017-09-26

A study was made by a combination of 3D electron tomography reconstruction methods and N 2 adsorption for determining the fractal dimension for nanometric MoS 2 and MoS 2 /Co catalyst particles. DFT methods including Neimarke-Kiselev's method allowed to determine the particle porosity and fractal arrays at the atomic scale for the S-Mo-S(Co) 2D- layers that conform the spherically shaped catalyst particles. A structural and textural correlation was sought by further characterization performed by x-ray Rietveld refinement and Radial Distribution Function (RDF) methods, electron density maps, computational density functional theory methods and nitrogen adsorption methods altogether, for studying the structural and textural features of spherical MoS 2 and MoS 2 /Co particles. Neimark-Kiselev's equations afforded the evaluation of a pore volume variation from 10 to 110 cm 3 /g by cobalt insertion in the MoS 2 crystallographic lattice, which induces the formation of cavities and throats in between of less than 29 nm, with a curvature radius r k  < 14.4 nm; typical large needle-like arrays having 20 2D layers units correspond to a model consisting of smooth surfaces within these cavities. Decreasing D P , D B , D I and D M values occur when Co atoms are present in the MoS 2 laminates, which promote the formation of smoother edges and denser surfaces that have an influence on the catalytic properties of the S-Mo-S(Co) system.

Exploring the ϒ (4 S ,5 S ,6 S )→hb(1 P )η hidden-bottom hadronic transitions

NASA Astrophysics Data System (ADS)

Zhang, Yawei; Li, Gang

2018-01-01

Recently, the Belle Collaboration has reported the measurement of the spin-flipping transition ϒ (4 S )→hb(1 P )η with an unexpectedly large branching ratio: B (ϒ (4 S )→hb(1 P )η )=(2.18 ±0.11 ±0.18 )×10-3 . Such a large branching fraction contradicts with the anticipated suppression for the spin flip. In this work, we examine the effects induced by intermediate bottomed meson loops and point out that these effects are significantly important. Using the effective Lagrangian approach (ELA), we find the experimental data on ϒ (4 S )→hb(1 P )η can be accommodated with the reasonable inputs. We then explore the decays ϒ (5 S ,6 S )→hb(1 P )η and find that these two channels also have sizable branching fractions. We also calculate these processes in the framework of nonrelativistic effective field theory (NREFT). For the decays ϒ (4 S )→hb(1 P )η , the NREFT results are at the same order of magnitude but smaller than the ELA results by a factor of 2 to 5. For the decays ϒ (5 S ,6 S )→hb(1 P )η , the NREFT results are smaller than the ELA results by approximately 1 order of magnitude. We suggest a future experiment Belle-II to search for the ϒ (5 S ,6 S )→hb(1 P )η decays, which will be helpful for understanding the transition mechanism.

The relationship between perceived physical competence and fundamental motor skills in preschool children.

PubMed

Robinson, Leah E

2011-07-01

The purpose of this investigation had two folds. First, it aimed to discover the relationship between perceived physical competence and fundamental motor skills in preschoolers. Secondly, it examined the effect of sex on perceived physical competence and fundamental motor skills within the sample. A total of 119 children (mean age 4.00, SD 0.55 years) participated in this study. The Test of Gross Motor Development--2nd Edition was used to assess fundamental motor skills and the Pictorial Scale of Perceived Competence and Social Acceptance was used to assess perceived physical competence. The results show a moderate and significant correlation between perceived physical competence and fundamental motor skills. Sex differences were also found with boys demonstrating more proficient motor skills and reporting higher perceived physical competence compared with girls. The findings provide relevant information to the child development literature and suggest that a positive relationship exist between preschoolers' self-perceptions of the physical ability and fundamental motor skills. © 2010 Blackwell Publishing Ltd.

High-Resolution Fourier Transform Infrared Spectrum of the ν 12 Fundamental Band of Ethylene (C 2H 4)

NASA Astrophysics Data System (ADS)

Tan, T. L.; Lau, S. Y.; Ong, P. P.; Goh, K. L.; Teo, H. H.

2000-10-01

The infrared spectrum of the ν12 fundamental band of ethylene (C2H4) has been measured with an unapodized resolution of 0.004 cm-1 in the frequency range of 1380-1500 cm-1 using the Fourier transform technique. By assigning and fitting a total of 1387 infrared transitions using a Watson's A-reduced Hamiltonian in the Ir representation, rovibrational constants for the upper state (v12 = 1) up to five quartic and three sextic centrifugal distortions terms were derived. They represent the most accurate constants for the band so far. The rms deviation of the fit was 0.00033 cm-1. The A-type ν12 band with a band center at 1442.44299 ± 0.00003 cm-1 was found to be relatively free from local frequency perturbations. The inertial defect Δ12 was found to be 0.24201 ± 0.00002 u Å2.

Infusing fundamental cause theory with features of Pierre Bourdieu's theory of symbolic power.

PubMed

Veenstra, Gerry

2018-02-01

The theory of fundamental causes is one of the more influential attempts to provide a theoretical infrastructure for the strong associations between indicators of socioeconomic status (education, income, occupation) and health. It maintains that people of higher socioeconomic status have greater access to flexible resources such as money, knowledge, prestige, power, and beneficial social connections that they can use to reduce their risks of morbidity and mortality and minimize the consequences of disease once it occurs. However, several key aspects of the theory remain underspecified, compromising its ability to provide truly compelling explanations for socioeconomic health inequalities. In particular, socioeconomic status is an assembly of indicators that do not necessarily cohere in a straightforward way, the flexible resources that disproportionately accrue to higher status people are not clearly defined, and the distinction between socioeconomic status and resources is ambiguous. I attempt to address these definitional issues by infusing fundamental cause theory with features of a well-known theory of socioeconomic stratification in the sociological literature-Pierre Bourdieu's theory of symbolic power.

Microfluidics—from fundamental research to industrial applications

NASA Astrophysics Data System (ADS)

Köster, Sarah

2013-03-01

The advance of microfluidics started in the early 1980s. At the time, researchers realized that many processes and reactions in chemistry and biology, which typically take place on small length scales, can be defined, controlled and understood much better when using tools on equally small length scales. Reactions and reaction kinetics rely on (gradual) concentration differences and microfluidics provides the unique possibility to establish exactly such gradients of solutes, ion concentrations, pH value and so on. Nowadays the variety of specific microfluidic methods is large. In principle, they can be divided into two groups: (i) monophase flow, where miscible (e.g. aqueous) fluids are mixed, mostly by diffusion owing to the laminar flow on small length scales and (ii) multiphase flow, the most prominent example of which is probably droplet microfluidics, where water-in-oil or oil-in-water emulsions are used to encapsulate chemical or biological systems and separate them from each other, much like in 'micron-scale test tubes'. Now, 30 years later, microfluidic techniques are seriously considered for industrial applications, although some important steps in the upscaling process are still missing. The purpose of this special issue is to shed light on the different aspects in microfluidics research starting from fundamental research reaching all the way to industrial applications. The study by Toma and co-workers takes advantage of the controlled diffusive mixing when co-flowing aqueous, miscible solutions. They combine microfluidics with optical, spectroscopic and scattering techniques to study DNA packing. Nunes et al review the different regimes when replacing one of the fluids by an oil phase and varying flow rates and device geometries with a particular emphasis on using multiphase microfluidics for synthesis of particles or fibres. Going into the third dimension by fabricating microfluidic devices with several layers, producing emulsions can also be achieved by

Measuring the rate of change of voice fundamental frequency in fluent speech during mental depression.

PubMed

Nilsonne, A; Sundberg, J; Ternström, S; Askenfelt, A

1988-02-01

A method of measuring the rate of change of fundamental frequency has been developed in an effort to find acoustic voice parameters that could be useful in psychiatric research. A minicomputer program was used to extract seven parameters from the fundamental frequency contour of tape-recorded speech samples: (1) the average rate of change of the fundamental frequency and (2) its standard deviation, (3) the absolute rate of fundamental frequency change, (4) the total reading time, (5) the percent pause time of the total reading time, (6) the mean, and (7) the standard deviation of the fundamental frequency distribution. The method is demonstrated on (a) a material consisting of synthetic speech and (b) voice recordings of depressed patients who were examined during depression and after improvement.

Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait

PubMed Central

Decock, Anneleen; Ongenaert, Maté; De Wilde, Bram; Brichard, Bénédicte; Noguera, Rosa; Speleman, Frank; Vandesompele, Jo

2016-01-01

ABSTRACT Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at diagnosis and is associated with an excellent outcome due to its remarkable capacity to undergo spontaneous regression. As genomics have not been able to explain this intriguing clinical presentation, we here aimed at profiling the DNA methylome of stage 4S NB to better understand this phenomenon. To this purpose, differential methylation analyses between International Neuroblastoma Staging System (INSS) stage 4S, stage 4 and stage 1/2 were performed, using methyl-CpG-binding domain (MBD) sequencing data of 14 stage 4S, 14 stage 4, and 13 stage 1/2 primary NB tumors (all MYCN non-amplified in order not to confound results). Stage 4S-specific hyper- and hypomethylated promoters were determined and further characterized for genomic localization and function by cytogenetic band enrichment, gene set enrichment, transcription factor target enrichment and differential RNA expression analyses. We show that specific chromosomal locations are enriched for stage 4S differentially methylated promoters and that stage 4S tumors show characteristic hypermethylation of specific subtelomeric promoters. Furthermore, genes involved in important oncogenic pathways, in neural crest development and differentiation, and in epigenetic processes are differentially methylated and expressed in stage 4S tumors. Based on these findings, we describe new biological mechanisms possibly contributing to the stage 4S-specific tumor biology and spontaneous regression. In conclusion, this study is the first to describe the highly characteristic stage 4S DNA methylome. These findings will open new avenues to further unravel the NB pathology in general and stage 4S disease specifically. PMID:27599161

Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait.

PubMed

Decock, Anneleen; Ongenaert, Maté; De Wilde, Bram; Brichard, Bénédicte; Noguera, Rosa; Speleman, Frank; Vandesompele, Jo

2016-09-06

Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at diagnosis and is associated with an excellent outcome due to its remarkable capacity to undergo spontaneous regression. As genomics have not been able to explain this intriguing clinical presentation, we here aimed at profiling the DNA methylome of stage 4S NB to better understand this phenomenon. To this purpose, differential methylation analyses between International Neuroblastoma Staging System (INSS) stage 4S, stage 4 and stage 1/2 were performed, using methyl-CpG-binding domain (MBD) sequencing data of 14 stage 4S, 14 stage 4, and 13 stage 1/2 primary NB tumors (all MYCN non-amplified in order not to confound results). Stage 4S-specific hyper- and hypo-methylated promoters were determined and further characterized for genomic localization and function by cytogenetic band enrichment, gene set enrichment, transcription factor target enrichment and differential RNA expression analyses. We show that specific chromosomal locations are enriched for stage 4S differentially methylated promoters and that stage 4S tumors show characteristic hypermethylation of subtelomeres. Furthermore, genes involved in important oncogenic pathways, in neural crest development and differentiation, and in epigenetic processes are differentially methylated and expressed in stage 4S tumors. Based on these findings, we describe new biological mechanisms possibly contributing to the stage 4S-specific tumor biology and spontaneous regression. In conclusion, this study is the first to describe the highly characteristic stage 4S DNA methylome. These findings will open new avenues to further unravel the NB pathology in general and stage 4S disease specifically.

Second harmonic generation response of the cubic chalcogenides Ba( 6-x)Sr x[Ag( 4-y)Sn( y/4)](SnS 4) 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haynes, Alyssa S.; Liu, Te-Kun; Frazer, Laszlo

We synthesized the barium/strontium solid solution sequence Ba 6-xSr x[Ag( 4-y)Sn( y/4)](SnS 4) 4 for nonlinear optical (NLO) applications in the infrared (IR) via a flux synthesis route. All title compounds are isotypic, crystallizing in the cubic space group Imore » $$\\bar{_4}$$ 3d and are composed of a three-dimensional (3D) anionic framework of alternating corner-sharing SnS 4 and AgS 4 tetrahedra charge balanced by Ba and Sr. The shrinkage of Ba/Sr-S bond lengths causes the tetrahedra in the anionic framework to become more distorted, which results in a tunable band gap from 1.58 to 1.38 eV with increasing x values. The performance of the barium limit (x=0) is also superior to that of Sr (x=6), but surprisingly second harmonic generation (SHG) of the solid solution remains strong and is insensitive to the value of x over the range 0-3.8. Results show that the non-type-I phase-matched SHG produced by these cubic chalcogenides display intensities higher than the benchmark AgGaSe 2 from 600 to 1000 nm.« less

Relations between big five traits and fundamental motives.

PubMed

Olson, Kenneth R; Weber, Dale A

2004-12-01

Relations were examined between configurations of Big Five Traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism, Openness to Experience) and 16 fundamental motives (Social Contact, Curiosity, Honor, Power, Order, Idealism, Independence, Status, Vengeance, Romance, Family, Activity, Saving, Acceptance, Eating, Tranquility) in 138 university students (93 women, 45 men; M age= 20.3 yr., SD=4.5). Big Five traits were measured with the NEO-PI-R and motives were measured with the Reiss Profile of Fundamental Goals and Motivation Sensitivities. The traits were significantly related with all the motives (adjusted R2=.06 to .43) except Physical Activity. Four motives were related with only one trait and nine configurations of two or more traits were correlated with the remaining 11 motives. Total motive scores across all participants, an index of the strength of overall motivation, were positively correlated with Extraversion and Neuroticism and negatively with Agreeableness.

Fundamentals of Chemistry at Surfaces and Beyond

DTIC Science & Technology

2013-09-23

results of this research were published in J. Phys. Chem. C.34 B4. Fundamental Theory of Organic/Inorganic Hybrid Solar Cells In the field of...B, 104, 538-547 (2000). 38B. O’Regan, M. Gratzel, “A Low-Cost, High-Efficiency Solar Cell Based on Dye-Sensitized Colloidal TiO2 Films,” Nature...N. Murakami, H. J. Snaith, “Efficient Hybrid Solar Cells Based on Meso-Superstructured Organometal Halide Perovskites,” Sci. Exp., DOI: 10.1126

4. Photocopy of plat (from U.S. Land Commission, U.S. District ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of plat (from U.S. Land Commission, U.S. District Court, Northern District of California, G. Black, Surveyor, 1854) SITE PLAN OF MISSION SAN FRANCISCO SOLANO DE SONOMA - Mission San Francisco Solano de Sonoma, First & Spain Streets, Sonoma, Sonoma County, CA

Fundamental Science with Pulsed Power: Research Opportunities and User Meeting.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mattsson, Thomas Kjell Rene; Wootton, Alan James; Sinars, Daniel Brian

The fifth Fundamental Science with Pulsed Power: Research Opportunities and User Meeting was held in Albuquerque, NM, July 20-­23, 2014. The purpose of the workshop was to bring together leading scientists in four research areas with active fundamental science research at Sandia’s Z facility: Magnetized Liner Inertial Fusion (MagLIF), Planetary Science, Astrophysics, and Material Science. The workshop was focused on discussing opportunities for high-­impact research using Sandia’s Z machine, a future 100 GPa class facility, and possible topics for growing the academic (off-Z-campus) science relevant to the Z Fundamental Science Program (ZFSP) and related projects in astrophysics, planetary science, MagLIF-more » relevant magnetized HED science, and materials science. The user meeting was for Z collaborative users to: a) hear about the Z accelerator facility status and plans, b) present the status of their research, and c) be provided with a venue to meet and work as groups. Following presentations by Mark Herrmann and Joel Lash on the fundamental science program on Z and the status of the Z facility where plenary sessions for the four research areas. The third day of the workshop was devoted to breakout sessions in the four research areas. The plenary-­ and breakout sessions were for the four areas organized by Dan Sinars (MagLIF), Dylan Spaulding (Planetary Science), Don Winget and Jim Bailey (Astrophysics), and Thomas Mattsson (Material Science). Concluding the workshop were an outbrief session where the leads presented a summary of the discussions in each working group to the full workshop. A summary of discussions and conclusions from each of the research areas follows and the outbrief slides are included as appendices.« less

Alanine and glycine conjugates of (2S,4R)-4-[18F]fluoroglutamine for tumor imaging.

PubMed

Zha, Zhihao; Ploessl, Karl; Lieberman, Brian P; Wang, Limin; Kung, Hank F

2018-05-01

Glutamine is an essential source of energy, metabolic substrates, and building block for supporting tumor proliferation. Previously, (2S,4R)-4-[ 18 F]fluoroglutamine (4F-Gln) was reported as a glutamine-related metabolic imaging agent. To improve the in vivo kinetics of this radiotracer, two new dipeptides, [ 18 F]Gly-(2S,4R)4-fluoroglutamine (Gly-4F-Gln) and [ 18 F]Ala-(2S,4R)4-fluoroglutamine (Ala-4F-Gln) were investigated. Radiolabeling was performed via 2-steps 18 F-fluorination. Cell uptake studies of Gly-4F-Gln and Ala-4F-Gln were investigated in 9 L cell lines. In vitro and in vivo metabolism studies were carried out in Fisher 344 rats. Biodistribution and microPET imaging studies were performed in 9 L tumor-bearing rats. In vitro incubation of these [ 18 F]dipeptides in rat and human blood showed a rapid conversion to (2S,4R)-4-[ 18 F]fluoroglutamine (t 1/2  = 2.3 and 0.2 min for [ 18 F]Gly-4F-Gln and [ 18 F]Ala-4F-Gln, respectively for human blood). Biodistribution and PET imaging in Fisher 344 rats bearing 9 L tumor xenografts showed that these dipeptides rapidly localized in the tumors, comparable to that of (2S,4R)-4-[ 18 F]fluoroglutamine (4F-Gln). The results support that these dipeptides, [ 18 F]Gly-4F-Gln and [ 18 F]Ala-4F-Gln, are prodrugs, which hydrolyze in the blood after an iv injection. They appear to be selectively taken up and trapped by tumor tissue in vivo. The dipeptide, [ 18 F]Ala-4F-Gln, may be suitable as a PET tracer for imaging glutaminolysis in tumors. Copyright © 2018 Elsevier Inc. All rights reserved.

Earth-Abundant Chalcogenide Photovoltaic Devices with over 5% Efficiency Based on a Cu2 BaSn(S,Se)4 Absorber.

PubMed

Shin, Donghyeop; Zhu, Tong; Huang, Xuan; Gunawan, Oki; Blum, Volker; Mitzi, David B

2017-06-01

In recent years, Cu 2 ZnSn(S,Se) 4 (CZTSSe) materials have enabled important progress in associated thin-film photovoltaic (PV) technology, while avoiding scarce and/or toxic metals; however, cationic disorder and associated band tailing fundamentally limit device performance. Cu 2 BaSnS 4 (CBTS) has recently been proposed as a prospective alternative large bandgap (~2 eV), environmentally friendly PV material, with ~2% power conversion efficiency (PCE) already demonstrated in corresponding devices. In this study, a two-step process (i.e., precursor sputter deposition followed by successive sulfurization/selenization) yields high-quality nominally pinhole-free films with large (>1 µm) grains of selenium-incorporated (x = 3) Cu 2 BaSnS 4- x Se x (CBTSSe) for high-efficiency PV devices. By incorporating Se in the sulfide film, absorber layers with 1.55 eV bandgap, ideal for single-junction PV, have been achieved within the CBTSSe trigonal structural family. The abrupt transition in quantum efficiency data for wavelengths above the absorption edge, coupled with a strong sharp photoluminescence feature, confirms the relative absence of band tailing in CBTSSe compared to CZTSSe. For the first time, by combining bandgap tuning with an air-annealing step, a CBTSSe-based PV device with 5.2% PCE (total area 0.425 cm 2 ) is reported, >2.5× better than the previous champion pure sulfide device. These results suggest substantial promise for the emerging Se-rich Cu 2 BaSnS 4- x Se x family for high-efficiency and earth-abundant PV. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fundamentals and Catalytic Applications of CeO2-Based Materials.

PubMed

Montini, Tiziano; Melchionna, Michele; Monai, Matteo; Fornasiero, Paolo

2016-05-25

Cerium dioxide (CeO2, ceria) is becoming an ubiquitous constituent in catalytic systems for a variety of applications. 2016 sees the 40(th) anniversary since ceria was first employed by Ford Motor Company as an oxygen storage component in car converters, to become in the years since its inception an irreplaceable component in three-way catalysts (TWCs). Apart from this well-established use, ceria is looming as a catalyst component for a wide range of catalytic applications. For some of these, such as fuel cells, CeO2-based materials have almost reached the market stage, while for some other catalytic reactions, such as reforming processes, photocatalysis, water-gas shift reaction, thermochemical water splitting, and organic reactions, ceria is emerging as a unique material, holding great promise for future market breakthroughs. While much knowledge about the fundamental characteristics of CeO2-based materials has already been acquired, new characterization techniques and powerful theoretical methods are deepening our understanding of these materials, helping us to predict their behavior and application potential. This review has a wide view on all those aspects related to ceria which promise to produce an important impact on our life, encompassing fundamental knowledge of CeO2 and its properties, characterization toolbox, emerging features, theoretical studies, and all the catalytic applications, organized by their degree of establishment on the market.

Health Aspects of Climate Change in Cities with Mediterranean Climate, and Local Adaptation Plans

PubMed Central

Paz, Shlomit; Negev, Maya; Clermont, Alexandra; Green, Manfred S.

2016-01-01

Cities with a Mediterranean-type climate (Med-cities) are particularly susceptible to health risks from climate change since they are located in biogeographical hot-spots that experience some of the strongest effects of the changing climate. The study aims to highlight health impacts of climate change in Med-cities, analyze local climate adaptation plans and make adaptation policy recommendations for the Med-city level. We identified five Med-cities with a climate change adaptation plan: Adelaide, Barcelona, Cape Town, Los Angeles and Santiago. Beyond their similar Med-climate features (although Santiago’s are slightly different), the cities have different socio-economic characteristics in various aspects. We analyzed each plan according to how it addresses climate change-related drivers of health impacts among city dwellers. For each driver, we identified the types of policy adaptation tools that address it in the urban climate adaptation plans. The surveyed cities address most of the fundamental climate change-related drivers of risks to human health, including rising temperatures, flooding and drought, but the policy measures to reduce negative impacts vary across cities. We suggest recommendations for Med-cities in various aspects, depending on their local needs and vulnerability challenges: assessment of health risks, extreme events management and long-term adaptation, among others. PMID:27110801

Influence of the environment on the [4Fe-4S]2+ to [2Fe-2S]2+ cluster switch in the transcriptional regulator FNR.

PubMed

Crack, Jason C; Gaskell, Alisa A; Green, Jeffrey; Cheesman, Myles R; Le Brun, Nick E; Thomson, Andrew J

2008-02-06

In Escherichia coli, the switch between aerobic and anaerobic metabolism is primarily controlled by the fumarate and nitrate reduction transcriptional regulator FNR. In the absence of O2, FNR binds a [4Fe-4S]2+ cluster, generating a transcriptionally active dimeric form. Exposure to O2 results in the conversion of the cluster to a [2Fe-2S]2+ form, leading to dissociation of the protein into transcriptionally inactive monomers. The [4Fe-4S]2+ to [2Fe-2S]2+ cluster conversion proceeds in two steps. Step 1 involves the one-electron oxidation of the cluster, resulting in the release of Fe2+, generating a [3Fe-4S]1+ cluster intermediate, and a superoxide ion. In step 2, the cluster intermediate spontaneously rearranges to form the [2Fe-2S]2+ cluster, with the release of a Fe3+ ion and two sulfide ions. Here, we demonstrate that, in both native and reconstituted [4Fe-4S] FNR, the reaction environment and, in particular, the presence of Fe2+ and/or Fe3+ chelators can influence significantly the cluster conversion reaction. We demonstrate that while the rate of step 1 is largely insensitive to chelators, that of step 2 is significantly enhanced by both Fe2+ and Fe3+ chelators. We show that, for reactions in Fe3+-coordinating phosphate buffer, step 2 is enhanced to the extent that step 1 becomes the rate determining step and the [3Fe-4S]1+ intermediate is no longer detectable. Furthermore, Fe3+ released during this step is susceptible to reduction in the presence of Fe2+ chelators. This work, which may have significance for the in vivo FNR cluster conversion reaction in the cell cytoplasm, provides an explanation for apparently contradictory results reported from different laboratories.

STS-117 S3 and S4 Trusses in the Space Shuttle Atlantis Cargo Bay

NASA Technical Reports Server (NTRS)

2007-01-01

This nadir view of the STS-117 mission Space Shuttle Atlantis, taken by the Expedition 15 crew aboard the International Space Station (ISS), occurred just before the two spacecraft linked up in Earth orbit. Berthed in the cargo bay are the 17.8 ton second and third (S3 and S4) truss segments ready for installment. STS-117 mission objectives included the addition of S3 and S4 with Photovoltaic Radiator (PVR), the deployment of the third set of solar arrays, and the retraction of the P4 starboard solar array wing and one radiator.

Visualizing the Fundamental Physics of Rapid Earth Penetration Using Transparent Soils

DTIC Science & Technology

2015-03-01

L R E P O R T DTRA-TR-14-80 Visualizing the Fundamental Physics of Rapid Earth Penetration Using Transparent Soils Approved for public... ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS...dose absorbed) roentgen shake slug torr (mm Hg, 0 C) *The bacquerel (Bq) is the SI unit of radioactivity ; 1 Bq = 1 event/s. **The Gray (GY) is

Verb Aspect and the Activation of Event Knowledge

ERIC Educational Resources Information Center

Ferretti, Todd R.; Kutas, Marta; McRae, Ken

2007-01-01

The authors show that verb aspect influences the activation of event knowledge with 4 novel results. First, common locations of events (e.g., arena) are primed following verbs with imperfective aspect (e.g., was skating) but not verbs with perfect aspect (e.g., had skated). Second, people generate more locative prepositional phrases as…

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

PubMed Central

Zhou, Qian; Liu, Chunxiao; Liu, Wen; Zhang, Hai; Zhang, Ruijie; Liu, Jia; Zhang, Jinfei; Xu, Chong; Liu, Lei; Huang, Shile; Chen, Long

2015-01-01

Rotenone, a common pesticide and inhibitor of mitochondrial complex I, induces loss of dopaminergic neurons and consequential aspects of Parkinson’s disease (PD). However, the exact mechanism of rotenone neurotoxicity is not fully elucidated. Here, we show that rotenone induced reactive oxygen species (ROS), leading to apoptotic cell death in PC12 cells and primary neurons. Pretreatment with catalase (CAT), a hydrogen peroxide-scavenging enzyme, attenuated rotenone-induced ROS and neuronal apoptosis, implying hydrogen peroxide (H2O2) involved, which was further verified by imaging intracellular H2O2 using a peroxide-selective probe H2DCFDA. Using thenoyltrifluoroacetone (TTFA), antimycin A, or Mito-TEMPO, we further demonstrated rotenone-induced mitochondrial H2O2-dependent neuronal apoptosis. Rotenone dramatically inhibited mTOR-mediated phosphorylation of S6K1 and 4E-BP1, which was also attenuated by CAT in the neuronal cells. Of interest, ectopic expression of wild-type mTOR or constitutively active S6K1, or downregulation of 4E-BP1 partially prevented rotenone-induced H2O2 and cell apoptosis. Furthermore, we noticed that rotenone-induced H2O2 was linked to the activation of caspase-3 pathway. This was evidenced by the finding that pretreatment with CAT partially blocked rotenone-induced cleavages of caspase-3 and poly (ADP-ribose) polymerase. Of note, zVAD-fmk, a pan caspase inhibitor, only partially prevented rotenone-induced apoptosis in PC12 cells and primary neurons. Expression of mTOR-wt, S6K1-ca, or silencing 4E-BP1 potentiated zVAD-fmk protection against rotenone-induced apoptosis in the cells. The results indicate that rotenone induction of H2O2 inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, resulting in caspase-dependent and -independent apoptosis in neuronal cells. Our findings suggest that rotenone-induced neuronal loss in PD may be prevented by activating mTOR signaling and/or administering antioxidants. PMID:25304210

Joint inversion of high-frequency surface waves with fundamental and higher modes

USGS Publications Warehouse

Luo, Y.; Xia, J.; Liu, J.; Liu, Q.; Xu, S.

2007-01-01

Joint inversion of multimode surface waves for estimating the shear (S)-wave velocity has received much attention in recent years. In this paper, we first analyze sensitivity of phase velocities of multimodes of surface waves for a six-layer earth model, and then we invert surface-wave dispersion curves of the theoretical model and a real-world example. Sensitivity analysis shows that fundamental mode data are more sensitive to the S-wave velocities of shallow layers and are concentrated on a very narrow frequency band, while higher mode data are more sensitive to the parameters of relatively deeper layers and are distributed over a wider frequency band. These properties provide a foundation of using a multimode joint inversion to define S-wave velocities. Inversion results of both synthetic data and a real-world example demonstrate that joint inversion with the damped least-square method and the singular-value decomposition technique to invert high-frequency surface waves with fundamental and higher mode data simultaneously can effectively reduce the ambiguity and improve the accuracy of S-wave velocities. ?? 2007.

32 CFR 2001.16 - Fundamental classification guidance review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Fundamental classification guidance review. 2001... INFORMATION Classification § 2001.16 Fundamental classification guidance review. (a) Performance of fundamental classification guidance reviews. An initial fundamental classification guidance review shall be...

Isotope shift of 40,42,44,48Ca in the 4s 2S1/2 → 4p 2P3/2 transition

NASA Astrophysics Data System (ADS)

Gorges, C.; Blaum, K.; Frömmgen, N.; Geppert, Ch; Hammen, M.; Kaufmann, S.; Krämer, J.; Krieger, A.; Neugart, R.; Sánchez, R.; Nörtershäuser, W.

2015-12-01

We report on improved isotope shift measurements of the isotopes {}{40,42,{44,48}}Ca in the 4{{s}}{ }2{{{S}}}1/2\\to 4{{p}}{ }2{{{P}}}3/2 (D2) transition using collinear laser spectroscopy. Accurately known isotope shifts in the 4{{s}}{ }2{{{S}}}1/2\\to 4{{p}}{ }2{{{P}}}1/2(D1) transition were used to calibrate the ion beam energy with an uncertainty of {{Δ }}U≈ +/- 0.25 {{V}}. The accuracy in the D2 transition was improved by a factor of 5-10. A King-plot analysis of the two transitions revealed that the field shift factor in the D2 line is about 1.8(13)% larger than in the D1 transition which is ascribed to relativistic contributions of the 4{{{p}}}1/2 wave function.

Fundamentals of Geophysics

NASA Astrophysics Data System (ADS)

Frohlich, Cliff

Choosing an intermediate-level geophysics text is always problematic: What should we teach students after they have had introductory courses in geology, math, and physics, but little else? Fundamentals of Geophysics is aimed specifically at these intermediate-level students, and the author's stated approach is to construct a text “using abundant diagrams, a simplified mathematical treatment, and equations in which the student can follow each derivation step-by-step.” Moreover, for Lowrie, the Earth is round, not flat—the “fundamentals of geophysics” here are the essential properties of our Earth the planet, rather than useful techniques for finding oil and minerals. Thus this book is comparable in both level and approach to C. M. R. Fowler's The Solid Earth (Cambridge University Press, 1990).

Fundamentals of Marketing Core Curriculum. Test Items and Assessment Techniques.

ERIC Educational Resources Information Center

Smith, Clifton L.; And Others

This document contains multiple choice test items and assessment techniques for Missouri's fundamentals of marketing core curriculum. The core curriculum is divided into these nine occupational duties: (1) communications in marketing; (2) economics and marketing; (3) employment and advancement; (4) human relations in marketing; (5) marketing…

[IgG4-related disease].

PubMed

González-Moreno, Juan; Losada López, Inés; Ortego Centeno, Norberto

2015-12-21

IgG4-related disease is a recently described clinicopathological entity showing a wide spectrum of clinical manifestations that share a common pathology. Its most characteristic feature is the formation of inflammatory tumors in different organs, which makes differentiation mainly with neoplastic diseases fundamental. The inflammatory process is typically comprised of IgG4 lymphoplasmacytic cells. The pathophysiological role of the immunoglobulin is not clear. The treatment of choice is corticosteroids. This article aims to summarize the main features of the disease. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.

PubMed

Chapman, A G; Talebi, A; Yip, P K; Meldrum, B S

2001-07-20

The metabotropic Group III agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-1), selective for the mGlu(4alpha) receptor, suppresses sound-induced seizures in DBA/2 mice following its intracerebroventricular (i.c.v.) administration (ED(50) 5.6 [2.9-10.7], nmol i.c.v., 15 min, clonic phase) and in genetically epilepsy-prone (GEP) rats following focal administration into the inferior colliculus (ED(50) 0.08 [0.01-0.50], nmol, 60 min, clonic phase). ACPT-1 also protects against clonic seizures induced in DBA/2 mice by the Group I agonist, (RS)-3,5-dihydroxyphenylglycine (3,5-DHPG) (ED(50) 0.60 [0.29-1.2], nmol i.c.v.) and by the Group III antagonist, (RS)-alpha-methylserine-O-phosphate (MSOP) (ED(50) 49.3 [37.9-64.1], nmol i.c.v.). Another Group III agonist, (RS)-4-phosphonophenyl-glycine (PPG), preferentially activating the mGlu(8) receptor, previously shown to protect against sound-induced seizures in DBA/2 mice and GEP rats, also protects against seizures induced in DBA/2 by 3,5-DHPG (ED(50) 3.7 [2.4-5.7], nmol i.c.v.) and by the Group III antagonist, MSOP (ED(50) 40.2 [21.0-77.0], nmol i.c.v.). At very high doses (500 nmol i.c.v. and above), Group III antagonists have pro-convulsant and convulsant activity. The anticonvulsant protection against sound-induced seizures in DBA/2 mice provided by a fully protective dose (20 nmol, i.c.v.) of the mGlu(4) receptor agonist ACPT-1, is partially reversed by the co-administration of the Group III antagonists, MSOP, (RS)-alpha-methyl-4-phosphonophenylglycine (MPPG) or (S)-2-amino-2-methyl-4-phosphonobutanoic acid (MAP4), in the 20-50 nmol dose range. At doses of 50-200 nmol, MPPG and MAP4 cause further reversal of the ACPT-1 anticonvulsant protection, while the MSOP effect on ACPT-1 protection is abolished at higher doses. In contrast, the anticonvulsant protection against sound-induced seizures in DBA/2 mice provided by a fully protective dose (20 nmol, i.c.v.) of the mGlu(8) receptor agonist PPG, is not

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.

PubMed

Muro, Fumihito; Iimura, Shin; Sugimoto, Yuuichi; Yoneda, Yoshiyuki; Chiba, Jun; Watanabe, Toshiyuki; Setoguchi, Masaki; Iigou, Yutaka; Matsumoto, Keiko; Satoh, Atsushi; Takayama, Gensuke; Taira, Tomoe; Yokoyama, Mika; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo

2009-12-24

We have focused on optimization of the inadequate pharmacokinetic profile of trans-4-substituted cyclohexanecarboxylic acid 5, which is commonly observed in many small molecule very late antigen-4 (VLA-4) antagonists. We modified the lipophilic moiety in 5 and found that reducing the polar surface area of this moiety results in improvement of the PK profile. Consequently, our efforts have led to the discovery of trans-4-[1-[[2,5-dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid (14e) with potent activity (IC(50) = 5.4 nM) and significantly improved bioavailability in rats, dogs, and monkeys (100%, 91%, 68%), which demonstrated excellent oral efficacy in murine and guinea pig models of asthma. Based on its overall profile, compound 14e was progressed into clinical trails. In a single ascending-dose phase I clinical study, compound 14e exhibited favorable oral exposure as expected and had no serious adverse events.

Photospheric properties and fundamental parameters of M dwarfs

NASA Astrophysics Data System (ADS)

Rajpurohit, A. S.; Allard, F.; Teixeira, G. D. C.; Homeier, D.; Rajpurohit, S.; Mousis, O.

2018-02-01

Context. M dwarfs are an important source of information when studying and probing the lower end of the Hertzsprung-Russell (HR) diagram, down to the hydrogen-burning limit. Being the most numerous and oldest stars in the galaxy, they carry fundamental information on its chemical history. The presence of molecules in their atmospheres, along with various condensed species, complicates our understanding of their physical properties and thus makes the determination of their fundamental stellar parameters more challenging and difficult. Aim. The aim of this study is to perform a detailed spectroscopic analysis of the high-resolution H-band spectra of M dwarfs in order to determine their fundamental stellar parameters and to validate atmospheric models. The present study will also help us to understand various processes, including dust formation and depletion of metals onto dust grains in M dwarf atmospheres. The high spectral resolution also provides a unique opportunity to constrain other chemical and physical processes that occur in a cool atmosphere. Methods: The high-resolution APOGEE spectra of M dwarfs, covering the entire H-band, provide a unique opportunity to measure their fundamental parameters. We have performed a detailed spectral synthesis by comparing these high-resolution H-band spectra to that of the most recent BT-Settl model and have obtained fundamental parameters such as effective temperature, surface gravity, and metallicity (Teff, log g, and [Fe/H]), respectively. Results: We have determined Teff, log g, and [Fe/H] for 45 M dwarfs using high-resolution H-band spectra. The derived Teff for the sample ranges from 3100 to 3900 K, values of log g lie in the range 4.5 ≤ log g ≤ 5.5, and the resulting metallicities lie in the range ‑0.5 ≤ [Fe/H] ≤ +0.5. We have explored systematic differences between effective temperature and metallicity calibrations with other studies using the same sample of M dwarfs. We have also shown that the stellar

The Azotobacter vinelandii NifEN complex contains two identical [4Fe-4S] clusters.

PubMed

Goodwin, P J; Agar, J N; Roll, J T; Roberts, G P; Johnson, M K; Dean, D R

1998-07-21

The nifE and nifN gene products from Azotobacter vinelandii form an alpha2beta2 tetramer (NifEN complex) that is required for the biosynthesis of the nitrogenase FeMo cofactor. In the current model for NifEN complex organization and function, the complex is structurally analogous to the nitrogenase MoFe protein and provides an assembly site for a portion of FeMo cofactor biosynthesis. In this work, gene fusion and immobilized metal-affinity chromatography strategies were used to elevate the in vivo production of the NifEN complex and to facilitate its rapid and efficient purification. The NifEN complex produced and purified in this way exhibits an FeMo cofactor biosynthetic activity similar to that previously described for the NifEN complex purified by traditional chromatography methods. UV-visible, EPR, variable-temperature magnetic circular dichroism, and resonance Raman spectroscopies were used to show that the NifEN complex contains two identical [4Fe-4S]2+ clusters. These clusters have a predominantly S = 1/2 ground state in the reduced form, exhibit a reduction potential of -350 mV, and are likely to be coordinated entirely by cysteinyl residues on the basis of spectroscopic properties and sequence comparisons. A model is proposed where each NifEN complex [4Fe-4S] cluster is bridged between a NifE-NifN subunit interface at a position analogous to that occupied by the P clusters in the nitrogenase MoFe protein. In contrast to the MoFe protein P clusters, the NifEN complex [4Fe-4S] clusters are proposed to be asymmetrically coordinated to the NifEN complex where NifE cysteines-37, -62, and -124 and NifN cysteine-44 are the coordinating ligands. On the basis of a homology model of the three-dimensional structure of the NifEN complex, the [4Fe-4S] cluster sites are likely to be remote from the proposed FeMo cofactor assembly site and are unlikely to become incorporated into the FeMo cofactor during its assembly.

Measurement of fundamental illite particle thicknesses by X-ray diffraction using PVP-10 intercalation

USGS Publications Warehouse

Eberl, D.D.; Nüesch, R.; Šucha, Vladimír; Tsipursky, S.

1998-01-01

The thicknesses of fundamental illite particles that compose mixed-layer illite-smectite (I-S) crystals can be measured by X-ray diffraction (XRD) peak broadening techniques (Bertaut-Warren-Averbach [BWA] method and integral peak-width method) if the effects of swelling and XRD background noise are eliminated from XRD patterns of the clays. Swelling is eliminated by intercalating Na-saturated I-S with polyvinylpyrrolidone having a molecular weight of 10,000 (PVP-10). Background is minimized by using polished metallic silicon wafers cut perpendicular to (100) as a substrate for XRD specimens, and by using a single-crystal monochromator. XRD measurements of PVP-intercalated diagenetic, hydrothermal and low-grade metamorphic I-S indicate that there are at least 2 types of crystallite thickness distribution shapes for illite fundamental particles, lognormal and asymptotic; that measurements of mean fundamental illite particle thicknesses made by various techniques (Bertant-Warren-Averbach, integral peak width, fixed cation content, and transmission electron microscopy [TEM]) give comparable results; and that strain (small differences in layer thicknesses) generally has a Gaussian distribution in the log-normal-type illites, but is often absent in the asymptotic-type illites.

Vibrational relaxation in liquid chloroform following ultrafast excitation of the CH stretch fundamental

NASA Astrophysics Data System (ADS)

Sibert, Edwin L.; Rey, Rossend

2002-01-01

Vibrational energy flow in liquid chloroform that follows the ultrafast excitation of the CH stretch fundamental is modeled using semiclassical methods. Relaxation rates are calculated using Landau-Teller theory and a time-dependent method both of which consider a quantum mechanical CHCl3 solute molecule coupled to a classical bath of CHCl3 solvent molecules. Probability flow is examined for several potentials to determine the sensitivity of calculated relaxation rates to the parameters that describe the model potentials. Three stages of relaxation are obtained. Probability is calculated to decay initially to a single acceptor state, a combination state of the solute molecule with two quanta of excitation in the CH bend and one in the CCl stretch, in 13-23 ps depending on the potential model employed. This is followed by rapid and complex intramolecular energy flow into the remaining vibrational degrees of freedom. During this second stage the lowest frequency Cl-C-Cl bend is found to serve as a conduit for energy loss to the solvent. The bottleneck for relaxation back to the ground state is predicted to be the slow 100-200 ps relaxation of the CH bend and CCl stretch fundamentals. Several aspects of the incoherent anti-Stokes scattering that follows strong infrared excitation of the CH fundamental as observed by Graener, Zürl, and Hoffman [J. Phys. Chem. B 101, 1745 (1997)] are elucidated in the present study.

S100A9 Interaction with TLR4 Promotes Tumor Growth

PubMed Central

Källberg, Eva; Vogl, Thomas; Liberg, David; Olsson, Anders; Björk, Per; Wikström, Pernilla; Bergh, Anders; Roth, Johannes; Ivars, Fredrik; Leanderson, Tomas

2012-01-01

By breeding TRAMP mice with S100A9 knock-out (S100A9−/−) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression. CD11b+ S100A9 expressing cells were not observed in normal prostate tissue from control C57BL/6 mice but were readily detected in TRAMP prostate tumors. Also, S100A9 expression was observed in association with CD68+ macrophages in biopsies from human prostate tumors. Delayed growth of TRAMP tumors was also observed in mice lacking the S100A9 ligand TLR4. In the EL-4 lymphoma model tumor growth inhibition was observed in S100A9−/− and TLR4−/−, but not in RAGE−/− animals lacking an alternative S100A9 receptor. When expression of immune-regulating genes was analyzed using RT-PCR the only common change observed in mice lacking S100A9 and TLR4 was a down-regulation of TGFβ expression in splenic CD11b+ cells. Lastly, treatment of mice with a small molecule (ABR-215050) that inhibits S100A9 binding to TLR4 inhibited EL4 tumor growth. Thus, S100A9 and TLR4 appear to be involved in promoting tumor growth in two different tumor models and pharmacological inhibition of S100A9-TLR4 interactions is a novel and promising target for anti-tumor therapies. PMID:22470535

Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteins

PubMed Central

2010-01-01

The reactivity of protein bound iron−sulfur clusters with nitric oxide (NO) is well documented, but little is known about the actual mechanism of cluster nitrosylation. Here, we report studies of members of the Wbl family of [4Fe−4S] containing proteins, which play key roles in regulating developmental processes in actinomycetes, including Streptomyces and Mycobacteria, and have been shown to be NO responsive. Streptomyces coelicolor WhiD and Mycobacterium tuberculosis WhiB1 react extremely rapidly with NO in a multiphasic reaction involving, remarkably, 8 NO molecules per [4Fe−4S] cluster. The reaction is 104-fold faster than that observed with O2 and is by far the most rapid iron−sulfur cluster nitrosylation reaction reported to date. An overall stoichiometry of [Fe4S4(Cys)4]2− + 8NO → 2[FeI2(NO)4(Cys)2]0 + S2− + 3S0 has been established by determination of the sulfur products and their oxidation states. Kinetic analysis leads to a four-step mechanism that accounts for the observed NO dependence. DFT calculations suggest the possibility that the nitrosylation product is a novel cluster [FeI4(NO)8(Cys)4]0 derived by dimerization of a pair of Roussin’s red ester (RRE) complexes. PMID:21182249

Fundamentals of fluid lubrication

NASA Technical Reports Server (NTRS)

Hamrock, Bernard J.

1991-01-01

The aim is to coordinate the topics of design, engineering dynamics, and fluid dynamics in order to aid researchers in the area of fluid film lubrication. The lubrication principles that are covered can serve as a basis for the engineering design of machine elements. The fundamentals of fluid film lubrication are presented clearly so that students that use the book will have confidence in their ability to apply these principles to a wide range of lubrication situations. Some guidance on applying these fundamentals to the solution of engineering problems is also provided.

Fundamentals of fluid sealing

NASA Technical Reports Server (NTRS)

Zuk, J.

1976-01-01

The fundamentals of fluid sealing, including seal operating regimes, are discussed and the general fluid-flow equations for fluid sealing are developed. Seal performance parameters such as leakage and power loss are presented. Included in the discussion are the effects of geometry, surface deformations, rotation, and both laminar and turbulent flows. The concept of pressure balancing is presented, as are differences between liquid and gas sealing. Mechanisms of seal surface separation, fundamental friction and wear concepts applicable to seals, seal materials, and pressure-velocity (PV) criteria are discussed.

Fabrication of water-soluble polymer-encapsulated As4S4 to increase oral bioavailability and chemotherapeutic efficacy in AML mice

PubMed Central

Ma, Qiang; Wang, Chuan; Li, Xiaojin; Guo, Hua; Meng, Jie; Liu, Jian; Xu, Haiyan

2016-01-01

Realgar (As4S4) has been demonstrated to be effective for the treatment of acute myeloid leukemia (AML); it has the advantages of no drug resistance and oral administration. Nevertheless, its poor solubility has been an obstacle to its bioavailability, requiring high-dose administration over a long period. We investigated whether crushing realgar crystals to the nanoscale and encapsulating the particles in a water-soluble polymer in one step using hot-melt extrusion would increase the bioavailability of As4S4. Raw As4S4 (r-As4S4) and water-soluble polymer were processed via co-rotating twin screw extrusion. The resulting product (e-As4S4) was characterized by SEM, XRD, and DLS. The cytotoxicity and therapeutic effects of e-As4S4 were evaluated in vivo and in vitro. The results show that e-As4S4 dissolved rapidly in water, forming a stable colloid solution. The average size of e-As4S4 particles was 680 nm, which was reduced by more than 40-fold compared with that of r-As4S4. The bioavailability of e-As4S4 was up to 12.6-fold higher than that of r-As4S4, and it inhibited the proliferation of HL-60 cells much more effectively than did r-As4S4, inducing apoptosis and significantly reducing the infiltration of HL-60 cells into the bone marrow, spleen, and liver. This in turn prolonged the survival of AML mice. PMID:27383126

Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3–S4 linker

PubMed Central

Gonzalez, Carlos; Rosenman, Eduardo; Bezanilla, Francisco; Alvarez, Osvaldo; Latorre, Ramon

2001-01-01

Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu. This charge movement leads to channel opening. In Shaker K+ channels four positively charged arginines in the S4 domain are transferred from the internal to the external side of the channel during activation. The distance traveled by the S4 segment during activation is unknown, but large movements should be constrained by the S3–S4 linker. Constructing deletion mutants, we show that the activation time constant and the midpoint of the voltage activation curve of the Shaker K+ channel macroscopic currents becomes a periodic function of the S3–S4 linker length for linkers shorter than 7 aa residues. The periodicity is that typical of α-helices. Moreover, a linker containing only 3 aa is enough to recover the wild-type phenotype. The deletion method revealed the importance of the S3–S4 linker in determining the channel gating kinetics and indicated that the α-helical nature of S4 extends toward its N terminus. These results support the notion that a small displacement of the S4 segment suffices to displace the four gating charges involved in channel opening. PMID:11493701

S3 and S4 abundances and improved chemical kinetic model for the lower atmosphere of Venus

NASA Astrophysics Data System (ADS)

Krasnopolsky, Vladimir A.

2013-07-01

Mixing ratios of S3 and S4 are obtained from reanalysis of the spectra of true absorption in the visible range retrieved by Maiorov et al. (Maiorov, B.S. et al. [2005]. Solar Syst. Res. 39, 267-282) from the Venera 11 observations. These mixing ratios are fS3 = 11 ± 3 ppt at 3-10 km and 18 ± 3 ppt at 10-19 km, fS4 = 4 ± 4 ppt at 3-10 km and 6 ± 2 ppt at 10-19 km, and show a steep decrease in both S3 and S4 above 19 km. Photolysis rates of S3 and S4 at various altitudes are calculated using the Venera 11 spectra and constant photolysis yields as free parameters. The chemical kinetic model for the Venus lower atmosphere (Krasnopolsky, V.A. [2007]. Icarus 191, 25-37) has been improved by inclusion of the S4 cycle from Yung et al. (Yung, Y.L. et al. [2009]. J. Geophys. Res. 114, E00B34), reduction of the H2SO4 and CO fluxes at the upper boundary of 47 km by a factor of 4 in accord with the recent photochemical models for the middle atmosphere, by using a closed lower boundary for OCS instead of a free parameter for this species at the surface, and some minor updates. Our model with the S4 cycle but without the SO3 + 2 OCS reaction suggested by Krasnopolsky and Pollack (Krasnopolsky, V.A., Pollack, J.B. [1994]. Icarus 109, 58-78) disagrees with the observations of OCS, CO, S3, and S4. However, inclusion of the S4 cycle improves the model fit to all observational constraints. The best-fit activation energy of 7800 K for thermolysis of S4 supports the S4 enthalpy from Mills (Mills, K.C. [1974]. Thermodynamic Data for Inorganic Sulfides, Selenides and Tellurides. Butterworths, London). Chemistry of the Venus lower atmosphere is initiated by disequilibrium products H2SO4 and CO from the middle atmosphere, photolysis of S3 and S4, and thermochemistry in the lowest scale height. The chemistry is mostly driven by sulfur that is formed in a slow reaction SO + SO, produces OCS, and results in dramatic changes in abundances of OCS, CO, and free sulfur allotropes. The SX + OCS

High temperature neutron powder diffraction study of the Cu{sub 12}Sb{sub 4}S{sub 13} and Cu{sub 4}Sn{sub 7}S{sub 16} phases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemoine, Pierric, E-mail: pierric.lemoine@univ-rennes1.fr; Bourgès, Cédric; Barbier, Tristan

Ternary copper-containing sulfides Cu{sub 12}Sb{sub 4}S{sub 13} and Cu{sub 4}Sn{sub 7}S{sub 16} have attracted considerable interest since few years due to their high-efficiency conversion as absorbers for solar energy and promising thermoelectric materials. We report therein on the decomposition study of Cu{sub 12}Sb{sub 4}S{sub 13} and Cu{sub 4}Sn{sub 7}S{sub 16} phases using high temperature in situ neutron powder diffraction. Our results obtained at a heating rate of 2.5 K/min indicate that: (i) Cu{sub 12}Sb{sub 4}S{sub 13} decomposes above ≈792 K into Cu{sub 3}SbS{sub 3}, and (ii) Cu{sub 4}Sn{sub 7}S{sub 16} decomposes above ≈891 K into Sn{sub 2}S{sub 3} and amore » copper-rich sulfide phase of sphalerite ZnS-type structure with an assumed Cu{sub 3}SnS{sub 4} stoichiometry. Both phase decompositions are associated to a sulfur volatilization. While the results on Cu{sub 12}Sb{sub 4}S{sub 13} are in fair agreement with recent published data, the decomposition behavior of Cu{sub 4}Sn{sub 7}S{sub 16} differs from other studies in terms of decomposition temperature, thermal stability and products of reaction. Finally, the crystal structure refinements from neutron powder diffraction data are reported and discussed for the Cu{sub 4}Sn{sub 7}S{sub 16} and tetrahedrite Cu{sub 12}Sb{sub 4}S{sub 13} phases at 300 K, and for the high temperature form of skinnerite Cu{sub 3}SbS{sub 3} at 843 K. - Graphical abstract: In situ neutron powder diffraction data (heating rate of 2.5 K/min) indicates that (i) the ternary Cu{sub 12}Sb{sub 4}S{sub 13} phase is stable up to 792 K and decomposes at higher temperature into Cu{sub 3}SbS{sub 3} and Cu{sub 1.5}Sb{sub 0.5}S{sub 2}, and (ii) the Cu{sub 4}Sn{sub 7}S{sub 16} phase is stable up to 891 K and decomposes at higher temperature into Sn{sub 2}S{sub 3} and a cubic phase of sphalerite ZnS-type structure. Sulfur volatilization likely occurs in order to balance the overall stoichiometry.« less

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

PubMed Central

Theilmann, J; Kanani, S; Shiang, R; Robbins, C; Quarrell, O; Huggins, M; Hedrick, A; Weber, B; Collins, C; Wasmuth, J J

1989-01-01

Analysis of many families with linked DNA markers has provided support for the Huntington's disease (HD) gene being close to the telomere on the short arm of chromosome 4. However, analysis of recombination events in particular families has provided conflicting results about the precise location of the HD gene relative to these closely linked DNA markers. Here we report an investigation of linkage disequilibrium between six DNA markers and the HD gene in 75 separate families of varied ancestry. We show significant non-random association between alleles detected at D4S95 and D4S98 and the mutant gene. These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90. This information may be helpful in defining a strategy to clone the gene for HD based on its location in the human genome. Images PMID:2531224

New insights into the structure, chemistry, and properties of Cu 4SnS 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choudhury, Amitava; Mohapatra, Sudip; Yaghoobnejad Asl, Hooman

The ambient temperature structure of Cu 4SnS 4 has been revisited and the recently reported low temperature structure has been confirmed from single-crystal X-ray diffraction data. A structural phase transition from a large monoclinic unit cell at low temperature to a smaller orthorhombic unit cell at high temperature has been observed. The room temperature phase exhibited disorder in the two copper sites, which is a different finding from earlier reports. The low temperature monoclinic form crystallizes in P2 1/c space group, which is isostructural with Cu 4GeS 4. The phase transition has also been studied with variable temperature powder X-raymore » diffraction and 119Sn Mössbauer spectroscopy. The Seebeck coefficients and electrical resistivity of polycrystalline Cu 4SnS 4 are reported from 16 to 400 K on hot pressed pellets. Thermal conductivity measurements at high temperatures, 350 – 750 K exhibited very low thermal conductivities in the range 0.28 – 0.35 W K –1 m –1. In all the transport measurements the phase transition has been observed at around 232 K. Resistivity decreases, while Seebeck coefficient increases after the phase transition during warming up from low to high temperatures. This change in resistivity has been correlated with the results of first-principles electronic band structure calculations using highly-accurate screened-exchange local density approximation. It was found that both the low hole effective mass of 0.63 me for the Γ→Y crystallographic direction and small band gap, 0.49 eV, are likely to contribute to the observed higher conductivity of the orthorhombic phase. Cu 4SnS 4 is also electrochemically active and shows reversible reaction with lithium between 1.7 and 3.5 volts.« less

New insights into the structure, chemistry, and properties of Cu 4SnS 4

DOE PAGES

Choudhury, Amitava; Mohapatra, Sudip; Yaghoobnejad Asl, Hooman; ...

2017-05-25

The ambient temperature structure of Cu 4SnS 4 has been revisited and the recently reported low temperature structure has been confirmed from single-crystal X-ray diffraction data. A structural phase transition from a large monoclinic unit cell at low temperature to a smaller orthorhombic unit cell at high temperature has been observed. The room temperature phase exhibited disorder in the two copper sites, which is a different finding from earlier reports. The low temperature monoclinic form crystallizes in P2 1/c space group, which is isostructural with Cu 4GeS 4. The phase transition has also been studied with variable temperature powder X-raymore » diffraction and 119Sn Mössbauer spectroscopy. The Seebeck coefficients and electrical resistivity of polycrystalline Cu 4SnS 4 are reported from 16 to 400 K on hot pressed pellets. Thermal conductivity measurements at high temperatures, 350 – 750 K exhibited very low thermal conductivities in the range 0.28 – 0.35 W K –1 m –1. In all the transport measurements the phase transition has been observed at around 232 K. Resistivity decreases, while Seebeck coefficient increases after the phase transition during warming up from low to high temperatures. This change in resistivity has been correlated with the results of first-principles electronic band structure calculations using highly-accurate screened-exchange local density approximation. It was found that both the low hole effective mass of 0.63 me for the Γ→Y crystallographic direction and small band gap, 0.49 eV, are likely to contribute to the observed higher conductivity of the orthorhombic phase. Cu 4SnS 4 is also electrochemically active and shows reversible reaction with lithium between 1.7 and 3.5 volts.« less

Transatlantic Multispecialty Consensus on Fundamental Endovascular Skills: Results of a Delphi Consensus Study.

PubMed

Maertens, H; Aggarwal, R; Macdonald, S; Vermassen, F; Van Herzeele, I

2016-01-01

The aim of this study was to establish a consensus on Fundamental Endovascular Skills (FES) for educational purposes and development of training curricula for endovascular procedures. The term "Fundamental Endovascular Skills" is widely used; however, the current literature does not explicitly describe what skills are included in this concept. Endovascular interventions are performed by several specialties that may have opposing perspectives on these skills. A two round Delphi questionnaire approach was used. Experts from interventional cardiology, interventional radiology, and vascular surgery from the United States and Europe were invited to participate. An electronic questionnaire was generated by endovascular therapists with an appropriate educational background but who would not participate in subsequent rounds. The questionnaire consisted of 50 statements describing knowledge, technical, and behavioral skills during endovascular procedures. Experts received the questionnaires by email. They were asked to rate the importance of each skill on a Likert scale from 1 to 5. A statement was considered fundamental when more than 90% of the experts rated it 4 or 5 out of 5. Twenty-three of 53 experts invited agreed to participate: six interventional radiologists (2 USA, 4 Europe), 10 vascular surgeons (4 USA, 6 Europe), and seven interventional cardiologists (4 USA, 3 Europe). There was a 100% response rate in the first round and 87% in the second round. Results showed excellent consensus among responders (Cronbach's alpha = .95 first round; .93 second round). Ninety percent of all proposed skills were considered fundamental. The most critical skills were determined. A transatlantic multispecialty consensus was achieved about the content of "FES" among interventional radiologists, interventional cardiologists, and vascular surgeons from Europe and the United States. These results can serve as directive principles for developing endovascular training curricula

Neutrons and Fundamental Symmetries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plaster, Bradley

2016-01-11

The research supported by this project addressed fundamental open physics questions via experiments with subatomic particles. In particular, neutrons constitute an especially ideal “laboratory” for fundamental physics tests, as their sensitivities to the four known forces of nature permit a broad range of tests of the so-called “Standard Model”, our current best physics model for the interactions of subatomic particles. Although the Standard Model has been a triumphant success for physics, it does not provide satisfactory answers to some of the most fundamental open questions in physics, such as: are there additional forces of nature beyond the gravitational, electromagnetic, weakmore » nuclear, and strong nuclear forces?, or why does our universe consist of more matter than anti-matter? This project also contributed significantly to the training of the next generation of scientists, of considerable value to the public. Young scientists, ranging from undergraduate students to graduate students to post-doctoral researchers, made significant contributions to the work carried out under this project.« less

Self-organization: the fundament of cell biology

PubMed Central

Betz, Timo

2018-01-01

Self-organization refers to the emergence of an overall order in time and space of a given system that results from the collective interactions of its individual components. This concept has been widely recognized as a core principle in pattern formation for multi-component systems of the physical, chemical and biological world. It can be distinguished from self-assembly by the constant input of energy required to maintain order—and self-organization therefore typically occurs in non-equilibrium or dissipative systems. Cells, with their constant energy consumption and myriads of local interactions between distinct proteins, lipids, carbohydrates and nucleic acids, represent the perfect playground for self-organization. It therefore comes as no surprise that many properties and features of self-organized systems, such as spontaneous formation of patterns, nonlinear coupling of reactions, bi-stable switches, waves and oscillations, are found in all aspects of modern cell biology. Ultimately, self-organization lies at the heart of the robustness and adaptability found in cellular and organismal organization, and hence constitutes a fundamental basis for natural selection and evolution. This article is part of the theme issue ‘Self-organization in cell biology’. PMID:29632257

Fundamental principles of conducting a surgery economic analysis study.

PubMed

Kotsis, Sandra V; Chung, Kevin C

2010-02-01

The use of economic evaluation in surgery is scarce. Economic evaluation is used even less so in plastic surgery, in which health-related quality of life is of particular importance. This article, part of a tutorial series on evidence-based medicine, focuses on the fundamental principles of conducting a surgery economic analysis. The authors include the essential aspects of conducting a surgical cost-utility analysis by considering perspectives, costs, outcomes, and utilities. The authors also describe and give examples of how to conduct the analyses (including calculating quality-adjusted life-years and discounting), how to interpret the results, and how to report the results. Although economic analyses are not simple to conduct, a well-conducted one provides many rewards, such as recommending the adoption of a more effective treatment. For comparing and interpreting economic analysis publications, it is important that all studies use consistent methodology and report the results in a similar manner.

Charles Augustin Coulomb and the fundamental law of electrostatics

NASA Astrophysics Data System (ADS)

Falconer, Isobel

2004-10-01

In his famous experiment on the inverse square law of electrostatics, Coulomb neither defined electric charge nor gave reliable measurements of the force-distance relation. Yet the experiment has often been viewed as the basis of the fundamental law of electrostatics. This paper discusses Coulomb's life, showing the context within which he was working, how he arrived at the experiment, and the use he made of it. Physics in France in the late 18th century was undergoing a transformation from a science of holistic observation and explanations to one of universal laws and exact measurement. Coulomb was both a subject of, and an important contributor to, this change, and these two aspects are evident in his approach to the experiment and to the later uptake of his results. The reaction in the rest of Europe was initially less favourable, and the ultimate fame of Coulomb's experiment was dependent on the triumph of French mathematical physics in the 19th century.

Synthesis and characterization of CdS/BiPO{sub 4} heterojunction photocatalyst

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Daimei, E-mail: chendaimei@cugb.edu.cn; Kuang, Zheng; Zhu, Qian

2015-06-15

Highlights: • A CdS/BiPO{sub 4} heterojunction was prepared by the solvothermal method. • The CdS/BiPO{sub 4} composite has the higher photocatalytic activity than the individual ones. • The optimal mass ratio of CdS to BiPO{sub 4} was 0.5. • The heterojunction structure of CdS/BiPO{sub 4} induces an effective electron–hole separation. - Abstract: A series of CdS/BiPO{sub 4} heterojunction photocatalysts with the visible-light response were synthesized by the solvothermal method. The resulting products were characterized by X-ray diffraction, Transmission electron microscopy, X-ray photoelectron spectroscopy, and UV–vis diffuse reflection spectroscopy. CdS nanoparticles with the size at range of 5–7 nm were immobilizedmore » on the surface of BiPO{sub 4} nanorods. The CdS/BiPO{sub 4} composite exhibited much higher photodegradation rate of methylene blue under visible light irradation compared to the pure CdS and BiPO{sub 4}. The optimal mass ratio of CdS to BiPO{sub 4} was 0.5, the photodegradation rate of which is 2.1 times higher than that of CdS. The enhancement of photocatalytic activity is attributed to the heterojunction structure of CdS/BiPO{sub 4} composite which induced the effective electron–hole separation between CdS and BiPO{sub 4}.« less

The association between fundamental athletic movements and physical fitness in elite junior Australian footballers.

PubMed

Woods, Carl T; McKeown, Ian; Keogh, Justin; Robertson, Sam

2018-02-01

This study investigated the associations between fundamental athletic movement and physical fitness in junior Australian football (AF). Forty-four under 18 players performed a fundamental athletic movement assessment consisting of an overhead squat, double lunge, single leg Romanian deadlift and a push up. Movements were scored on three assessment criterions using a three-point scale. Additionally, participants performed five physical fitness tests commonly used for talent identification in AF. A Spearman's nonparametric correlation matrix was built, with correlation coefficients being visualised using a circularly rendered correlogram. Score on the overhead squat was moderately positively associated with dynamic vertical jump height on left (r s  = 0.40; P ≤ 0.05) and right (r s  = 0.30; P ≤ 0.05) leg take-off, stationary vertical jump (r s  = 0.32; P ≤ 0.05) and negatively associated with 20-m sprint time (r s  = -0.35; P ≤ 0.05). Score on the double lunge (left/right side) was moderately positively associated with the same physical fitness tests as well as score on the multistage fitness test. Results suggest that improvements in physical fitness qualities may occur through concurrent increases in fundamental athletic movement skill, namely the overhead squat and double lunge movements. These findings may assist with the identification and development of talent.

Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD

PubMed Central

Crack, Jason C.; den Hengst, Chris D.; Jakimowicz, Piotr; Subramanian, Sowmya; Johnson, Michael K.; Buttner, Mark J.; Thomson, Andrew J.; Le Brun, Nick E.

2009-01-01

WhiD, a member of the WhiB-like (Wbl) family of iron-sulfur proteins found exclusively within the actinomycetes, is required for the late stages of sporulation in Streptomyces coelicolor. Like all other Wbl proteins, WhiD has not so far been purified in a soluble form that contains a significant amount of cluster and characterization has relied on cluster-reconstituted protein. Thus, a major goal in Wbl research is to obtain and characterize native protein containing iron-sulfur clusters. Here we report the analysis of S. coelicolor WhiD purified anaerobically from E. coli as a soluble protein containing a single [4Fe-4S]2+ cluster ligated by four cysteines. Upon exposure to oxygen, spectral features associated with the [4Fe-4S] cluster were lost in a slow reaction that unusually yielded apo-WhiD directly without significant concentrations of cluster intermediates. This process was found to be highly pH dependent with an optimal stability observed between pH 7.0 and 8.0. Low molecular weight thiols, including a mycothiol analogue and thioredoxin, exerted a small but significant protective effect against WhiD cluster loss, an activity that could be of physiological importance. [4Fe-4S]2+ WhiD was found to react much more rapidly with superoxide than with either oxygen or hydrogen peroxide, which may also be of physiological significance. Loss of the [4Fe-4S] cluster to form apo-protein destabilized the protein fold significantly, but did not lead to complete unfolding. Finally, apo-WhiD exhibited negligible activity in an insulin-based disulfide reductase assay demonstrating that it does not function as a general protein disulfide reductase. PMID:19954209

Nation and Language: Modern Aspects of Socio-Linguistic Development. Proceedings of the 4th International Conference (Lithuania, October 21-22, 2010)

ERIC Educational Resources Information Center

Online Submission, 2010

2010-01-01

The 4th international conference "Nation and Language: Modern Aspects of Socio-Linguistic Development" continues an eight-year old tradition. The conference is organized by Kaunas University of Technology Panevezys Institute and aims to bring scientists and researchers together for a general scientific discussion on new trends in…

The Acid-Base Properties, Hydrolytic Mechanism, and Susceptibility to O2 Oxidation of Fe4S4(SR)4-2 Clusters

PubMed Central

Bruice, Thomas C.; Maskiewicz, Richard; Job, Robert

1975-01-01

The iron-sulfur cluster compounds Fe4S4(SR)4-2 [where —SR = —SCH3, —S—C(CH3)3, and —S— CH2—CH(CH3)2] have been found to represent the base species of weak acids of pKa comparable to that of carboxylic acids. The acid species Fe4S4(SR)4H- is most subject to reaction with O2 and to acid-catalyzed solvolysis, while the base species Fe4S4(SR)4-2 most readily undergoes ligand exchange. The kinetics for hydrolysis of the isobutyl mercaptide cluster salt has been investigated in detail and a mechanism involving the stepwise process [Formula: see text] has been proposed. The importance of the acid-base equilibria in determining the reactivity of the iron-sulfur clusters and its possible importance as a factor in the determination of the potentials of ferredoxins and high potential iron protein are discussed. PMID:16592211

Absence of a fundamental acceleration scale in galaxies

NASA Astrophysics Data System (ADS)

Rodrigues, Davi C.; Marra, Valerio; del Popolo, Antonino; Davari, Zahra

2018-06-01

Dark matter is currently one of the main mysteries of the Universe. There is much strong indirect evidence that supports its existence, but there is yet no sign of a direct detection1-3. Moreover, at the scale of galaxies, there is tension between the theoretically expected dark matter distribution and its indirectly observed distribution4-7. Therefore, phenomena associated with dark matter have a chance of serving as a window towards new physics. The radial acceleration relation8,9 confirms that a non-trivial acceleration scale a0 can be found from the internal dynamics of several galaxies. The existence of such a scale is not obvious as far as the standard cosmological model is concerned10,11, and it has been interpreted as a possible sign of modified gravity12,13. Here, we consider 193 high-quality disk galaxies and, using Bayesian inference, show that the probability of existence of a fundamental acceleration is essentially 0: the null hypothesis is rejected at more than 10σ. We conclude that a0 is of emergent nature. In particular, the modified Newtonian dynamics theory14-17—a well-known alternative to dark matter based on the existence of a fundamental acceleration scale—or any other theory that behaves like it at galactic scales, is ruled out as a fundamental theory for galaxies at more than 10σ.

Fundamental movement skills and habitual physical activity in young children.

PubMed

Fisher, Abigail; Reilly, John J; Kelly, Louise A; Montgomery, Colette; Williamson, Avril; Paton, James Y; Grant, Stan

2005-04-01

To test for relationships between objectively measured habitual physical activity and fundamental movement skills in a relatively large and representative sample of preschool children. Physical activity was measured over 6 d using the Computer Science and Applications (CSA) accelerometer in 394 boys and girls (mean age 4.2, SD 0.5 yr). Children were scored on 15 fundamental movement skills, based on the Movement Assessment Battery, by a single observer. Total physical activity (r=0.10, P<0.05) and percent time spent in moderate to vigorous physical activity (MVPA) (r=0.18, P<0.001) were significantly correlated with total movement skills score. Time spent in light-intensity physical activity was not significantly correlated with motor skills score (r=0.02, P>0.05). In this sample and setting, fundamental movement skills were significantly associated with habitual physical activity, but the association between the two variables was weak. The present study questions whether the widely assumed relationships between motor skills and habitual physical activity actually exist in young children.

Different aspects of multiplicity distribution of shower particles in central collisions with AgBr target

NASA Astrophysics Data System (ADS)

Bhattacharyya, Swarnapratim; Haiduc, Maria; Neagu, Alina Tania; Firu, Elena

Different aspects like multiplicity moments, Dq moments and multiplicity fluctuations in terms of scaled variance of the shower particles has been carried out for central events of 16O-AgBr, 22Ne-AgBr and 32S-AgBr interactions at (4.1-4.5) AGeV/c. Comparison of our results with different experimental analysis of central collisions of emulsion data has been performed whenever available.

On the worldsheet theory of the type IIA {text{Ad}}{{text{S}}_4} × mathbb{C}{mathbb{P}_3} superstring

NASA Astrophysics Data System (ADS)

Sundin, Per

2010-04-01

We perform a detailed study of the type IIA superstring in {text{Ad}}{{text{S}}_4} × mathbb{C}{mathbb{P}_3} . After introducing suitable bosonic light-cone and fermionic kappa worldsheet gauges we derive the pure boson and fermion SU(2|2)×U(1) covariant light-cone Hamiltonian up to quartic order in fields. As a first application of our derivation we calculate energy shifts for string configurations in a closed fermionic subsector and successfully match these with a set of light-cone Bethe equations. We then turn to investigate the mismatch between the degrees of freedom of scattering states and oscillatory string modes. Since only light string modes appear as fundamental Bethe roots in the scattering theory, the physical role of the remaining 4 F + 4 B massive oscillators is rather unclear. By continuing a line of research initiated by Zarembo, we shed light on this question by calculating quantum corrections for the propagators of the bosonic massive fields. We show that, once loop corrections are incorporated, the massive coordinates dissolve in a continuum state of two light particles.

Fundamental and functional aspects of mesoscopic architectures with examples in physics, cell biology, and chemistry.

PubMed

Kalay, Ziya

2011-08-01

How small can a macroscopic object be made without losing its intended function? Obviously, the smallest possible size is determined by the size of an atom, but it is not so obvious how many atoms are required to assemble an object so small, and yet that performs the same function as its macroscopic counterpart. In this review, we are concerned with objects of intermediate nature, lying between the microscopic and the macroscopic world. In physics and chemistry literature, this regime in-between is often called mesoscopic, and is known to bear interesting and counterintuitive features. After a brief introduction to the concept of mesoscopic systems from the perspective of physics, we discuss the functional aspects of mesoscopic architectures in cell biology, and supramolecular chemistry through many examples from the literature. We argue that the biochemistry of the cell is largely regulated by mesoscopic functional architectures; however, the significance of mesoscopic phenomena seems to be quite underappreciated in biological sciences. With this motivation, one of our main purposes here is to emphasize the critical role that mesoscopic structures play in cell biology and biochemistry.

Fundamentals of neurogastroenterology: basic science.

PubMed

Grundy, David; Al-Chaer, Elie D; Aziz, Qasim; Collins, Stephen M; Ke, Meiyun; Taché, Yvette; Wood, Jackie D

2006-04-01

The focus of neurogastroenterology in Rome II was the enteric nervous system (ENS). To avoid duplication with Rome II, only advances in ENS neurobiology after Rome II are reviewed together with stronger emphasis on interactions of the brain, spinal cord, and the gut in terms of relevance for abdominal pain and disordered gastrointestinal function. A committee with expertise in selective aspects of neurogastroenterology was invited to evaluate the literature and provide a consensus overview of the Fundamentals of Neurogastroenterology textbook as they relate to functional gastrointestinal disorders (FGIDs). This review is an abbreviated version of a fuller account that appears in the forthcoming book, Rome III. This report reviews current basic science understanding of visceral sensation and its modulation by inflammation and stress and advances in the neurophysiology of the ENS. Many of the concepts are derived from animal studies in which the physiologic mechanisms underlying visceral sensitivity and neural control of motility, secretion, and blood flow are examined. Impact of inflammation and stress in experimental models relative to FGIDs is reviewed as is human brain imaging, which provides a means for translating basic science to understanding FGID symptoms. Investigative evidence and emerging concepts implicate dysfunction in the nervous system as a significant factor underlying patient symptoms in FGIDs. Continued focus on neurogastroenterologic factors that underlie the development of symptoms will lead to mechanistic understanding that is expected to directly benefit the large contingent of patients and care-givers who deal with FGIDs.

Relationships between Body Composition and Fundamental Movement Skills among Children and Adolescents

ERIC Educational Resources Information Center

Okely, Anthony D.; Booth, Michael L.; Chey, Tien

2004-01-01

The purpose of this study was to examine associations of fundamental movement skills (FMS) with measures of body composition. among children and adolescents. Secondary analyses of cross-sectional data collected from 4,363 children and adolescents in Grades 4, 6, 8, and 10 as part of the 1997 New South Wales Schools Fitness and Physical Activity…

Newly synthesized dihydroquinazoline derivative from the aspect of combined spectroscopic and computational study

NASA Astrophysics Data System (ADS)

El-Azab, Adel S.; Mary, Y. Sheena; Mary, Y. Shyma; Panicker, C. Yohannan; Abdel-Aziz, Alaa A.-M.; El-Sherbeny, Magda A.; Armaković, Stevan; Armaković, Sanja J.; Van Alsenoy, Christian

2017-04-01

In this work, spectroscopic characterization of 2-(2-(4-oxo-3-phenethyl-3,4-dihydroquinazolin-2-ylthio)ethyl)isoindoline-1,3-dione have been obtained with experimentally and theoretically. Complete assignments of fundamental vibrations were performed on the basis of the potential energy distribution of the vibrational modes and good agreement between the experimental and scaled wavenumbers has been achieved. Frontier molecular orbitals have been used as indicators of stability and reactivity. Intramolecular interactions have been investigated by NBO analysis. The dipole moment, linear polarizability and first and second order hyperpolarizability values were also computed. In order to determine molecule sites prone to electrophilic attacks DFT calculations of average local ionization energy (ALIE) and Fukui functions have been performed as well. Intra-molecular non-covalent interactions have been determined and analyzed by the analysis of charge density. Stability of title molecule have also been investigated from the aspect of autoxidation, by calculations of bond dissociation energies (BDE), and hydrolysis, by calculations of radial distribution functions after molecular dynamics (MD) simulations. In order to assess the biological potential of the title compound a molecular docking study towards breast cancer type 2 complex has been performed.

The Fundamentals of Care Framework as a Point-of-Care Nursing Theory.

PubMed

Kitson, Alison L

Nursing theories have attempted to shape the everyday practice of clinical nurses and patient care. However, many theories-because of their level of abstraction and distance from everyday caring activity-have failed to help nurses undertake the routine practical aspects of nursing care in a theoretically informed way. The purpose of the paper is to present a point-of-care theoretical framework, called the fundamentals of care (FOC) framework, which explains, guides, and potentially predicts the quality of care nurses provide to patients, their carers, and family members. The theoretical framework is presented: person-centered fundamental care (PCFC)-the outcome for the patient and the nurse and the goal of the FOC framework are achieved through the active management of the practice process, which involves the nurse and the patient working together to integrate three core dimensions: establishing the nurse-patient relationship, integrating the FOC into the patient's care plan, and ensuring that the setting or context where care is transacted and coordinated is conducive to achieving PCFC outcomes. Each dimension has multiple elements and subelements, which require unique assessment for each nurse-patient encounter. The FOC framework is presented along with two scenarios to demonstrate its usefulness. The dimensions, elements, and subelements are described, and next steps in the development are articulated.

New massive gravity and AdS(4) counterterms.

PubMed

Jatkar, Dileep P; Sinha, Aninda

2011-04-29

We show that the recently proposed Dirac-Born-Infeld extension of new massive gravity emerges naturally as a counterterm in four-dimensional anti-de Sitter space (AdS(4)). The resulting on-shell Euclidean action is independent of the cutoff at zero temperature. We also find that the same choice of counterterm gives the usual area law for the AdS(4) Schwarzschild black hole entropy in a cutoff-independent manner. The parameter values of the resulting counterterm action correspond to a c=0 theory in the context of the duality between AdS(3) gravity and two-dimensional conformal field theory. We rewrite this theory in terms of the gauge field that is used to recast 3D gravity as a Chern-Simons theory.

Thin film electroluminescent cells on the basis of Ce-doped CaGa2S4 and SrGa2S4 prepared by flash evaporation method

NASA Astrophysics Data System (ADS)

Gambarov, E.; Bayramov, A.; Kato, A.; Iida, S.

2006-09-01

Ce-doped CaGa2S4 and SrGa2S4 thin film electroluminescent (TFEL) devices were prepared for the first time on the basis of films deposited by flash evaporation method. Significant crystallization, stoichiometry improvement of the films and increase of photoluminescence intensity were found after annealing in H2S and O2 gas stream. EL spectra of the cells exhibited the characteristic double-band emission similar to that seen for Ce3+ activated CaGa2S4 and SrGa2S4 films under photon excitation. Applied voltage and frequency dependences of the electroluminescence were studied. Low voltage operation as low as 20 V was observed for these cells. Luminance of about 4 cd/m2 at 100 V operating voltage with 2.5 kHz frequency was achieved for the TFEL cell with films annealed in O2 gas stream.

Cyprinid herpesvirus 3: an interesting virus for applied and fundamental research.

PubMed

Rakus, Krzysztof; Ouyang, Ping; Boutier, Maxime; Ronsmans, Maygane; Reschner, Anca; Vancsok, Catherine; Jazowiecka-Rakus, Joanna; Vanderplasschen, Alain

2013-09-27

Cyprinid herpesvirus 3 (CyHV-3), a member of the family Alloherpesviridae is the causative agent of a lethal, highly contagious and notifiable disease in common and koi carp. The economic importance of common and koi carp industries together with the rapid spread of CyHV-3 worldwide, explain why this virus became soon after its isolation in the 1990s a subject of applied research. In addition to its economic importance, an increasing number of fundamental studies demonstrated that CyHV-3 is an original and interesting subject for fundamental research. In this review, we summarized recent advances in CyHV-3 research with a special interest for studies related to host-virus interactions.

Cyprinid herpesvirus 3: an interesting virus for applied and fundamental research

PubMed Central

2013-01-01

Cyprinid herpesvirus 3 (CyHV-3), a member of the family Alloherpesviridae is the causative agent of a lethal, highly contagious and notifiable disease in common and koi carp. The economic importance of common and koi carp industries together with the rapid spread of CyHV-3 worldwide, explain why this virus became soon after its isolation in the 1990s a subject of applied research. In addition to its economic importance, an increasing number of fundamental studies demonstrated that CyHV-3 is an original and interesting subject for fundamental research. In this review, we summarized recent advances in CyHV-3 research with a special interest for studies related to host-virus interactions. PMID:24073814

The spectral properties of DNA and RNA macromolecules at low temperatures: fundamental and applied aspects

NASA Astrophysics Data System (ADS)

Yashchuk, Valeriy M.; Kudrya, Vladislav Yu

2017-03-01

This paper summarizes the results of studies of the spectral properties—optical absorption, fluorescence and phosphorescence—of DNA and RNA macromolecules and synthetic poly-, oligo- and mono-nucleotides, which have been carried out in our laboratory. The system of first excited singlet and triplet energy levels for DNA and RNA is evaluated using low-temperature (4.2 K-77 K) luminescent measurements. The traps of the singlet and triplet electronic excitations in these compounds are identified. An important self-protection mechanism against photo-damage of DNA and RNA by UV photons or penetrative radiation based on the capture of triplet electronic-energy excitations by the most photostable centers—in DNA, the complex formed by neighboring adenosine (A) and thymidine (T) links; in RNA, the adenosine links—is described. It is confirmed that despite similarities in the chemical and partly energy structures DNA is more stable than RNA. The spectral manifestation of the telomeres (the important functional system) in DNA macromolecules is examined. The results obtained on telomere fragments provide the possibility of finding the configuration peculiarities of the triplet excitations traps in DNA macromolecules. The resulting spreading length of the migrating singlet (l s) and triplet (l t) excitations for DNA and RNA macromolecules are evaluated.

Proposed experiment to test fundamentally binary theories

NASA Astrophysics Data System (ADS)

Kleinmann, Matthias; Vértesi, Tamás; Cabello, Adán

2017-09-01

Fundamentally binary theories are nonsignaling theories in which measurements of many outcomes are constructed by selecting from binary measurements. They constitute a sensible alternative to quantum theory and have never been directly falsified by any experiment. Here we show that fundamentally binary theories are experimentally testable with current technology. For that, we identify a feasible Bell-type experiment on pairs of entangled qutrits. In addition, we prove that, for any n , quantum n -ary correlations are not fundamentally (n -1 ) -ary. For that, we introduce a family of inequalities that hold for fundamentally (n -1 ) -ary theories but are violated by quantum n -ary correlations.

China’s S&T Emergence: A Proposal for U.S. DOD-China Collaboration in Fundamental Research

DTIC Science & Technology

2008-03-01

U.S. National Science Foundation points out the rise of S&T capability in Asia.3 Within Asia, China is rapidly becoming a major player in S&T...3 National Science Foundation , Division of Science Resources Statistics, “Asia’s Rising Science and Technology Strength: Comparative...example, the National Science Foundation awarded the University of California Santa Barbara (UCSB) a $1.5 million grant to establish a research and

The analytical {\\mathscr{O}}({a}_{s}^{4}) expression for the polarized Bjorken sum rule in the miniMOM scheme and the consequences for the generalized Crewther relation

NASA Astrophysics Data System (ADS)

Kataev, A. L.; Molokoedov, V. S.

2017-12-01

The analytical {\\mathscr{O}}({a}s4) perturbative QCD expression for the flavour non-singlet contribution to the Bjorken polarized sum rule in the rather applicable at present gauge-dependent miniMOM scheme is obtained. For the considered three values of the gauge parameter, namely ξ = 0 (Landau gauge), ξ = -1 (anti-Feynman gauge) and ξ = -3 (Stefanis-Mikhailov gauge), the scheme-dependent coefficients are considerably smaller than the gauge-independent {\\overline{{MS}}} results. It is found that the fundamental property of the factorization of the QCD renormalization group β-function in the generalized Crewther relation, which is valid in the gauge-invariant {\\overline{{MS}}} scheme up to {\\mathscr{O}}({a}s4)-level at least, is unexpectedly valid at the same level in the miniMOM-scheme for ξ = 0, and for ξ = -1 and ξ = -3 in part.

STOL aircraft transient ground effects. Part 1: Fundamental analytical study

NASA Technical Reports Server (NTRS)

Goldhammer, M. I.; Crowder, J. P.; Smyth, D. N.

1975-01-01

The first phases of a fundamental analytical study of STOL ground effects were presented. Ground effects were studied in two dimensions to establish the importance of nonlinear effects, to examine transient aspects of ascent and descent near the ground, and to study the modelling of the jet impingement on the ground. Powered lift system effects were treated using the jet-flap analogy. The status of a three-dimensional jet-wing ground effect method was presented. It was shown, for two-dimensional unblown airfoils, that the transient effects are small and are primarily due to airfoil/freestream/ground orientation rather than to unsteady effects. The three-dimensional study showed phenomena similar to the two-dimensional results. For unblown wings, the wing/freestream/ground orientation effects were shown to be of the same order of magnitude as for unblown airfoils. This may be used to study the nonplanar, nonlinear, jet-wing ground effect.

Sociological Aspects of Deafness.

ERIC Educational Resources Information Center

World Federation of the Deaf, Rome (Italy).

Nine conference papers treat the sociological aspects of deafness. Included are "Individuals Being Deaf and Blind and Living with a Well Hearing Society" by A. Marx (German Federal Republic), "A Deaf Man's Experiences in a Hearing World" by A. B. Simon(U.S.A.), "Problem of Text Books and School Appliances for Vocational…

Course 12: Proteins: Structural, Thermodynamic and Kinetic Aspects

NASA Astrophysics Data System (ADS)

Finkelstein, A. V.

1 Introduction 2 Overview of protein architectures and discussion of physical background of their natural selection 2.1 Protein structures 2.2 Physical selection of protein structures 3 Thermodynamic aspects of protein folding 3.1 Reversible denaturation of protein structures 3.2 What do denatured proteins look like? 3.3 Why denaturation of a globular protein is the first-order phase transition 3.4 "Gap" in energy spectrum: The main characteristic that distinguishes protein chains from random polymers 4 Kinetic aspects of protein folding 4.1 Protein folding in vivo 4.2 Protein folding in vitro (in the test-tube) 4.3 Theory of protein folding rates and solution of the Levinthal paradox

Fundamental movement skills and physical activity among children living in low-income communities: a cross-sectional study

PubMed Central

2014-01-01

Background Although previous studies have demonstrated that children with high levels of fundamental movement skill competency are more active throughout the day, little is known regarding children’s fundamental movement skill competency and their physical activity during key time periods of the school day (i.e., lunchtime, recess and after-school). The purpose of this study was to examine the associations between fundamental movement skill competency and objectively measured moderate-to-vigorous physical activity (MVPA) throughout the school day among children attending primary schools in low-income communities. Methods Eight primary schools from low-income communities and 460 children (8.5 ± 0.6 years, 54% girls) were involved in the study. Children’s fundamental movement skill competency (TGMD-2; 6 locomotor and 6 object-control skills), objectively measured physical activity (ActiGraph GT3X and GT3X + accelerometers), height, weight and demographics were assessed. Multilevel linear mixed models were used to assess the cross-sectional associations between fundamental movement skills and MVPA. Results After adjusting for age, sex, BMI and socio-economic status, locomotor skill competency was positively associated with total (P = 0.002, r = 0.15) and after-school (P = 0.014, r = 0.13) MVPA. Object-control skill competency was positively associated with total (P < 0.001, r = 0.20), lunchtime (P = 0.03, r = 0.10), recess (P = 0.006, r = 0.11) and after-school (P = 0.022, r = 0.13) MVPA. Conclusions Object-control skill competency appears to be a better predictor of children’s MVPA during school-based physical activity opportunities than locomotor skill competency. Improving fundamental movement skill competency, particularly object-control skills, may contribute to increased levels of children’s MVPA throughout the day. Trial registration Australian New Zealand Clinical Trials Registry No: ACTRN

Analytical study of seismic effects of a solar receiver mounted on concrete towers with different fundamental periods

NASA Astrophysics Data System (ADS)

Deng, Lin

2016-05-01

This paper examines the seismic effects experienced by a solar receiver mounted on concrete towers with different fundamental periods. Ten concrete towers are modeled with the empty solar receiver structure and loaded solar receiver structure to examine the tower seismic effects on the solar receiver. The fundamental periods of the towers range from 0.22 seconds to 4.58 seconds, with heights ranging from 40.5 meters to 200 meters. Thirty earthquake ground motion records are used to investigate the responses of each of the combined receiver-on-tower models as well as the receiver-on-ground models by the STAAD Pro software using time history analyses. The earthquake ground motion records are chosen based on the ratio of the peak ground acceleration to the peak ground velocity, ranging from 0.29 g/m/s to 4.88 g/m/s. For each of the combined models, the base shear at the interface between the receiver and the concrete tower is compared with the base shear of the receiver-on-ground model, and the ratio of the two base shears represents the structure amplification factor. It is found that the peak mean plus one standard deviation value of the structure amplification factor matches well with equation 13.3-1 in ASCE 7-10 for the empty solar receiver structure. However, when the solar receiver structure is loaded with dead loads, the peak value is greatly suppressed, and using equation 13.3-1 in ASCE 7-10 will be overly conservative.

Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation.

PubMed

Shepard, Eric M; Byer, Amanda S; Aggarwal, Priyanka; Betz, Jeremiah N; Scott, Anna G; Shisler, Krista A; Usselman, Robert J; Eaton, Gareth R; Eaton, Sandra S; Broderick, Joan B

2017-06-27

Nature utilizes [FeFe]-hydrogenase enzymes to catalyze the interconversion between H 2 and protons and electrons. Catalysis occurs at the H-cluster, a carbon monoxide-, cyanide-, and dithiomethylamine-coordinated 2Fe subcluster bridged via a cysteine to a [4Fe-4S] cluster. Biosynthesis of this unique metallocofactor is accomplished by three maturase enzymes denoted HydE, HydF, and HydG. HydE and HydG belong to the radical S-adenosylmethionine superfamily of enzymes and synthesize the nonprotein ligands of the H-cluster. These enzymes interact with HydF, a GTPase that acts as a scaffold or carrier protein during 2Fe subcluster assembly. Prior characterization of HydF demonstrated the protein exists in both dimeric and tetrameric states and coordinates both [4Fe-4S] 2+/+ and [2Fe-2S] 2+/+ clusters [Shepard, E. M., Byer, A. S., Betz, J. N., Peters, J. W., and Broderick, J. B. (2016) Biochemistry 55, 3514-3527]. Herein, electron paramagnetic resonance (EPR) is utilized to characterize the [2Fe-2S] + and [4Fe-4S] + clusters bound to HydF. Examination of spin relaxation times using pulsed EPR in HydF samples exhibiting both [4Fe-4S] + and [2Fe-2S] + cluster EPR signals supports a model in which the two cluster types either are bound to widely separated sites on HydF or are not simultaneously bound to a single HydF species. Gel filtration chromatographic analyses of HydF spectroscopic samples strongly suggest the [2Fe-2S] + and [4Fe-4S] + clusters are coordinated to the dimeric form of the protein. Lastly, we examined the 2Fe subcluster-loaded form of HydF and showed the dimeric state is responsible for [FeFe]-hydrogenase activation. Together, the results indicate a specific role for the HydF dimer in the H-cluster biosynthesis pathway.

Binding S0.6 Se0.4 in 1D Carbon Nanofiber with CS Bonding for High-Performance Flexible Li-S Batteries and Na-S Batteries.

PubMed

Yao, Yu; Zeng, Linchao; Hu, Shuhe; Jiang, Yu; Yuan, Beibei; Yu, Yan

2017-05-01

A one-step synthesis procedure is developed to prepare flexible S 0.6 Se 0.4 @carbon nanofibers (CNFs) electrode by coheating S 0.6 Se 0.4 powder with electrospun polyacrylonitrile nanofiber papers at 600 °C. The obtained S 0.6 Se 0.4 @CNFs film can be used as cathode material for high-performance Li-S batteries and room temperature (RT) Na-S batteries directly. The superior lithium/sodium storage performance derives from its rational structure design, such as the chemical bonding between Se and S, the chemical bonding between S 0.6 Se 0.4 and CNFs matrix, and the 3D CNFs network. This easy one-step synthesis procedure provides a feasible route to prepare electrode materials for high-performance Li-S and RT Na-S batteries. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Institute's Program Eyes U.S. Technological Competitiveness.

ERIC Educational Resources Information Center

Lepkowski, Wil

1983-01-01

American Enterprise Institute (AEI) has launched a study exploring the role the United States government should play in industrial science and technology policy. Highlights various aspects of the study and provides a list of fundamental questions the AEI science policy agenda has raised. (JN)

Iron-sulfur cluster disassembly in the FNR protein of Escherichia coli by O2: [4Fe-4S] to [2Fe-2S] conversion with loss of biological activity

PubMed Central

Khoroshilova, Natalia; Popescu, Codrina; Münck, Eckard; Beinert, Helmut; Kiley, Patricia J.

1997-01-01

The transcription factor FNR (fumarate nitrate reduction) requires the presence of an iron-sulfur (Fe-S) cluster for its function as a global transcription regulator in Escherichia coli when oxygen becomes scarce. To define the oxidation state and type of Fe-S cluster present in the active form of FNR, we have studied anaerobically purified FNR with Mössbauer spectroscopy. Our data showed that this form of FNR contained a [4Fe-4S]2+ cluster (δ = 0.45 mm/s; ΔEQ = 1.22 mm/s) and that the [4Fe-4S]2+ cluster was rapidly destroyed on exposure of FNR to air. Under these conditions, the yellow–green active form of FNR turned deep red; analysis of sulfide indicated that 70% of the labile sulfide was still present, suggesting that the Fe-S cluster had been converted into a different form. Little [3Fe-4S] cluster was, however, detected by EPR. According to Mössbauer spectroscopy, the [4Fe-4S]2+ cluster was converted in about 60% yield to a [2Fe-2S]2+ cluster (δ = 0.28 mm/s; ΔEQ = 0.58 mm/s) following 17 min of exposure to air. The [2Fe-2S]2+ cluster form of FNR was much more stable to oxygen, but was unable to sustain biological activity (e.g., DNA binding). However, DNA binding and the absorption spectrum characteristic of the [4Fe-4S]2+ cluster could be largely restored from the [2Fe-2S]2+ form when Cys, Fe, DTT, and the NifS protein were added. It has yet to be determined whether the form of FNR containing the [2Fe-2S]2+ cluster has any biological significance, e.g., as an in vivo intermediate that is more rapidly converted to the active form than the apoprotein. PMID:9177174

High-efficiency Thin-film Fe 2SiS 4 and Fe 2GeS 4-based Solar Cells Prepared from Low-Cost Solution Precursors. Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Radu, Daniela Rodica; Liu, Mimi; Hwang, Po-yu

The project aimed to provide solar energy education to students from underrepresented groups and to develop a novel, nano-scale approach, in utilizing Fe 2SiS 4 and Fe 2GeS 4 materials as precursors to the absorber layer in photovoltaic thin-film devices. The objectives of the project were as follows: 1. Develop and implement one solar-related course at Delaware State University and train two graduate students in solar research. 2. Fabricate and characterize high-efficiency (larger than 7%) Fe 2SiS 4 and Fe 2GeS 4-based solar devices. The project has been successful in both the educational components, implementing the solar course at DSUmore » as well as in developing multiple routes to prepare the Fe 2GeS 4 with high purity and in large quantities. The project did not meet the efficiency objective, however, a functional solar device was demonstrated.« less

Pressure-enhanced superconductivity in Eu 3 Bi 2 S 4 F 4

DOE PAGES

Luo, Yongkang; Zhai, Hui -Fei; Zhang, Pan; ...

2014-12-17

The pressure effect on the newly discovered charge-transferred BiS 2-based superconductor, Eu 3Bi 2S 4F 4, with a T c of 1.5 K at ambient pressure, is investigated by transport and magnetic measurements. Accompanied with the enhancement of metallicity under pressures, the onset superconducting transition temperature increases abruptly around 1.0 GPa, reaching ~10.0 K at 2.26 GPa. Alternating current magnetic susceptibility measurements indicate that a new superconducting phase with a higher T c emerges and dominates at high pressures. In the broad pressure window of 0.68GPa≤p≤2.00 GPa, the high-T c phase coexists with the low-T c phase. Hall effect measurementsmore » reveal a significant difference in electronic structures between the two superconducting phases. As a result, our work devotes the effort to establish the commonality of pressure effect on the BiS 2-based superconductors, and also uncovers the importance of electron carrier density in the high-T c phase.« less

High efficiency Cu2ZnSn(S,Se)4 solar cells by applying a double In2S3/CdS emitter.

PubMed

Kim, Jeehwan; Hiroi, Homare; Todorov, Teodor K; Gunawan, Oki; Kuwahara, Masaru; Gokmen, Tayfun; Nair, Dhruv; Hopstaken, Marinus; Shin, Byungha; Lee, Yun Seog; Wang, Wei; Sugimoto, Hiroki; Mitzi, David B

2014-11-26

High-efficiency Cu2ZnSn(S,Se)4 solar cells are reported by applying In2S3/CdS double emitters. This new structure offers a high doping concentration within the Cu2ZnSn(S,Se)4 solar cells, resulting in a substantial enhancement in open-circuit voltage. The 12.4% device is obtained with a record open-circuit voltage deficit of 593 mV. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A national quality registers as a tool to audit items of the fundamentals of care to older patients with hip fractures.

PubMed

Hommel, Ami; Bååth, Carina

2016-06-01

The Swedish healthcare system has a unique resource in the national quality registers. A national quality registry contains individualised data concerning patient problems, medical interventions and outcomes after treatment, within all healthcare settings. Many healthcare settings face challenges related to the way they deliver the fundamentals of care, therefore, it is important to audit the outcome. It is estimated that the number of people aged 80 years or older will have almost quadrupled between 2000 and 2050. Hip fracture has been recognised as the most serious consequence of osteoporosis because of the risk of its complications, which include pain, acute confusional state, pressure ulcers, infections, disability, diminished quality of life and mortality. The aim of this study was therefore to explore if and how a national quality register can be used as an audit tool for the fundamentals of care when it concerns older patients suffering from a hip fracture. For this study we retrospectively selected and audited variables retrieved from the national quality hip fracture register. The audit included 1083 patients 80 years and older, consecutively admitted to a university hospital in the south of Sweden, in 2011-2013. Nearly half of the patients were admitted from their own homes and were living alone. Almost half of the patients could walk outdoors before the fracture occurred. After 4 months, 28.5% of the patients walked outdoors. Additionally, after 4 months about 30% of the patients were still suffering from pain after hip fracture surgery and still using analgesics. There was a reduction in length of stay between 2011 and 2013. As a part of the national quality register the questions from EQ5D were used before surgery and after 4 months. Before discharge from hospital there were less registered complications in 2012 and 2013 compared with 2011. The national hip fracture quality register allows healthcare staff to analyse nursing outcomes and to

Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction.

PubMed

Wagner, Tristan; Koch, Jürgen; Ermler, Ulrich; Shima, Seigo

2017-08-18

In methanogenic archaea, the carbon dioxide (CO 2 ) fixation and methane-forming steps are linked through the heterodisulfide reductase (HdrABC)-[NiFe]-hydrogenase (MvhAGD) complex that uses flavin-based electron bifurcation to reduce ferredoxin and the heterodisulfide of coenzymes M and B. Here, we present the structure of the native heterododecameric HdrABC-MvhAGD complex at 2.15-angstrom resolution. HdrB contains two noncubane [4Fe-4S] clusters composed of fused [3Fe-4S]-[2Fe-2S] units sharing 1 iron (Fe) and 1 sulfur (S), which were coordinated at the CCG motifs. Soaking experiments showed that the heterodisulfide is clamped between the two noncubane [4Fe-4S] clusters and homolytically cleaved, forming coenzyme M and B bound to each iron. Coenzymes are consecutively released upon one-by-one electron transfer. The HdrABC-MvhAGD atomic model serves as a structural template for numerous HdrABC homologs involved in diverse microbial metabolic pathways. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Science Highlights from the Spitzer Survey of Stellar Structure in Galaxies (S4G) & Public Release of S4G Data

NASA Astrophysics Data System (ADS)

Sheth, Kartik

2013-01-01

The Spitzer Survey of Stellar Structure in Galaxies (S4G) is the largest and the most homogenous survey of the distribution of mass and stellar structure in over 2,300 nearby galaxies. With an integration time of four minutes per pixel at 3.6 and 4.5 microns, the S4G maps are extremely deep, tracing the stellar surface densities of < 1 solar mass per square parsec! S4G is the ultimate survey of the endoskeleton of nearby galaxies from dwarfs to ellipticals and affords an incredible treasury of data which we can address a host of outstanding questions in galaxy evolution. At this special session we will present details on the public release of this survey which will include science ready images, masks for the foreground and background stars, globally integrated properties and radial profiles of all galaxies. In addition we will release the results from a GALFIT decomposition of 200 galaxies which will be supplemented with the remainder of the survey within six months. The data are being released through the NASA/IPAC Infrared Science Archive (IRSA). I will present an overview of the survey, the data we are releasing, introduce the speakers and present science highlights from the team.

Implementing Subduction Models in the New Mantle Convection Code Aspect

NASA Astrophysics Data System (ADS)

Arredondo, Katrina; Billen, Magali

2014-05-01

The geodynamic community has utilized various numerical modeling codes as scientific questions arise and computer processing power increases. Citcom, a widely used mantle convection code, has limitations and vulnerabilities such as temperature overshoots of hundreds or thousands degrees Kelvin (i.e., Kommu et al., 2013). Recently Aspect intended as a more powerful cousin, is in active development with additions such as Adaptable Mesh Refinement (AMR) and improved solvers (Kronbichler et al., 2012). The validity and ease of use of Aspect is important to its survival and role as a possible upgrade and replacement to Citcom. Development of publishable models illustrates the capacity of Aspect. We present work on the addition of non-linear solvers and stress-dependent rheology to Aspect. With a solid foundational knowledge of C++, these additions were easily added into Aspect and tested against CitcomS. Time-dependent subduction models akin to those in Billen and Hirth (2007) are built and compared in CitcomS and Aspect. Comparison with CitcomS assists in Aspect development and showcases its flexibility, usability and capabilities. References: Billen, M. I., and G. Hirth, 2007. Rheologic controls on slab dynamics. Geochemistry, Geophysics, Geosystems. Kommu, R., E. Heien, L. H. Kellogg, W. Bangerth, T. Heister, E. Studley, 2013. The Overshoot Phenomenon in Geodynamics Codes. American Geophysical Union Fall Meeting. M. Kronbichler, T. Heister, W. Bangerth, 2012, High Accuracy Mantle Convection Simulation through Modern Numerical Methods, Geophys. J. Int.

Synthesis and Mesomorphic Behavior of Poly((2S, 3S)-(+)-2-Chloro-3- Methylpentyl 4’-(Omega-Vinyloxyalkyloxy)biphenyl-4-Carboxylate)s with Ethyl and Propyl Alkyl Groups

DTIC Science & Technology

1994-06-30

1 . Synthesis of (2S, 3S)-(+)-2-chloro-3-methyl-pentyl 4’-(2-vinyloxyethyloxy) biphenyl-4-carboxylate (15-2...CH2)2-),7.65 (d, 3=8.3Hz, 2 ArH, m to -COO-), 8.11 (d, J=7.4Hz, 2 ArH, o to -COO-). 3-Chloroprop~yl- 1 -vinyl ether (13-3) The mixture of 3- chloropropan ...VA .% fo - " A’* *i f’. - % .oL.,ae- a * 1 nOl-6..io. Ocw. ’•.1ý’ ..a.. :l•t :...•.t ;,,31 -. 1 " 1 . 2 . 10 1 -- Of , • l 0’ i’*J.. e t *no suaqetg

Changes in speaking fundamental frequency characteristics with aging.

PubMed

Nishio, Masaki; Niimi, Seiji

2008-01-01

Changes in speaking fundamental frequency (SFF) associated with aging were studied in a total of 374 healthy normal speakers (187 males and 187 females) from adolescent to older age groups. Participants were asked to read a sample passage aloud, and acoustic analysis was performed. The main results were as follows: (1) Males exhibited no significant trend for SFF changes in aging. However, a slight increase was observed in participants aged 70 years or older. (2) Females in their 30s and 40s showed obviously lower frequencies than those in their 20s. Across all age groups, including the 80s, SFF tended to decrease markedly in association with aging. (3) The degree of SFF change in association with aging was much larger in females than in males. In addition, reference intervals (mean +/- 1.96 SD) obtained for males and females in each age group are considered useful for clinical detection of abnormalities of SFF, as well as for detection of laryngeal diseases causing SFF abnormality. 2008 S. Karger AG, Basel.

Multifactorial discrimination as a fundamental cause of mental health inequities.

PubMed

Khan, Mariam; Ilcisin, Misja; Saxton, Katherine

2017-03-04

The theory of fundamental causes explains why health disparities persist over time, even as risk factors, mechanisms, and diseases change. Using an intersectional framework, we evaluated multifactorial discrimination as a fundamental cause of mental health disparities. Using baseline data from the Project STRIDE: Stress, Identity, and Mental Health study, we examined the health effects of discrimination among individuals who self-identified as lesbian, gay, or bisexual. We used logistic and linear regression to assess whether multifactorial discrimination met the four criteria designating a fundamental cause, namely that the cause: 1) influences multiple health outcomes, 2) affects multiple risk factors, 3) involves access to resources that can be leveraged to reduce consequences of disease, and 4) reproduces itself in varied contexts through changing mechanisms. Multifactorial discrimination predicted high depression scores, psychological well-being, and substance use disorder diagnosis. Discrimination was positively associated with risk factors for high depression scores: chronic strain and total number of stressful life events. Discrimination was associated with significantly lower levels of mastery and self-esteem, protective factors for depressive symptomatology. Even after controlling for risk factors, discrimination remained a significant predictor for high depression scores. Among subjects with low depression scores, multifactorial discrimination also predicted anxiety and aggregate mental health scores. Multifactorial discrimination should be considered a fundamental cause of mental health inequities and may be an important cause of broad health disparities among populations with intersecting social identities.

33 CFR 86.03 - Limits of fundamental frequencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of fundamental frequencies. To ensure a wide variety of whistle characteristics, the fundamental... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Limits of fundamental frequencies. 86.03 Section 86.03 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY...

Fundamental electrode kinetics

NASA Technical Reports Server (NTRS)

Elder, J. P.

1968-01-01

Report presents the fundamentals of electrode kinetics and the methods used in evaluating the characteristic parameters of rapid-charge transfer processes at electrode-electrolyte interfaces. The concept of electrode kinetics is outlined, followed by the principles underlying the experimental techniques for the investigation of electrode kinetics.

Pump-probe photoelectron velocity-map imaging of autoionizing singly excited 4s{sup 1}4p{sup 6}np{sup 1}(n=7,8) and doubly excited 4s{sup 2}4p{sup 4}5s{sup 1}6p{sup 1} resonances in atomic krypton

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doughty, Benjamin; Haber, Louis H.; Leone, Stephen R.

2011-10-15

Pump-probe photoelectron velocity-map imaging, using 27-eV high-harmonic excitation and 786-nm ionization, is used to resolve overlapping autoionizing resonances in atomic krypton, obtaining two-photon photoelectron angular distributions (PADs) for singly and doubly excited states. Two features in the photoelectron spectrum are assigned to singly excited 4s{sup 1}4p{sup 6}np{sup 1} (n = 7,8) configurations and four features provide information about double excitation configurations. The anisotropy parameters for the singly excited 7p configuration are measured to be {beta}{sub 2} = 1.61 {+-} 0.06 and {beta}{sub 4} = 1.54 {+-} 0.16 while the 8p configuration gives {beta}{sub 2} = 1.23 {+-} 0.19 and {beta}{submore » 4} = 0.60 {+-} 0.15. These anisotropies most likely represent the sum of overlapping PADs from states of singlet and triplet spin multiplicities. Of the four bands corresponding to ionization of doubly excited states, two are assigned to 4s{sup 2}4p{sup 4}5s{sup 1}6p{sup 1} configurations that are probed to different J-split ion states. The two remaining doubly excited states are attributed to a previously observed, but unassigned, resonance in the vacuum-ultraviolet photoabsorption spectrum. The PADs from each of the double excitation states are also influenced by overlap from neighboring states that are not completely spectrally resolved. The anisotropies of the observed double excitation states are reported, anticipating future theoretical and experimental work to separate the overlapping PADs into the state resolved PADs. The results can be used to test theories of excited state ionization.« less

Higher spin gauge theory on fuzzy \\boldsymbol {S^4_N}

NASA Astrophysics Data System (ADS)

Sperling, Marcus; Steinacker, Harold C.

2018-02-01

We examine in detail the higher spin fields which arise on the basic fuzzy sphere S^4N in the semi-classical limit. The space of functions can be identified with functions on classical S 4 taking values in a higher spin algebra associated to \

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ammirati, Mark J.; Andrews, Kim M.; Boyer, David D.

2010-10-01

A series of 4-substituted proline amides was synthesized and evaluated as inhibitors of dipeptidyl pepdidase IV for the treatment of type 2 diabetes. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone (5) emerged as a potent (IC{sub 50} = 13 nM) and selective compound, with high oral bioavailability in preclinical species and low plasma protein binding. Compound 5, PF-00734200, was selected for development as a potential new treatment for type 2 diabetes.

High-Fidelity Computational Aerodynamics of the Elytron 4S UAV

NASA Technical Reports Server (NTRS)

Ventura Diaz, Patricia; Yoon, Seokkwan; Theodore, Colin R.

2018-01-01

High-fidelity Computational Fluid Dynamics (CFD) have been carried out for the Elytron 4S Unmanned Aerial Vehicle (UAV), also known as the converticopter "proto12". It is the scaled wind tunnel model of the Elytron 4S, an Urban Air Mobility (UAM) concept, a tilt-wing, box-wing rotorcraft capable of Vertical Take-Off and Landing (VTOL). The three-dimensional unsteady Navier-Stokes equations are solved on overset grids employing high-order accurate schemes, dual-time stepping, and a hybrid turbulence model using NASA's CFD code OVERFLOW. The Elytron 4S UAV has been simulated in airplane mode and in helicopter mode.

From fundamental studies of sporulation to applied spore research.

PubMed

Barák, Imrich; Ricca, Ezio; Cutting, Simon M

2005-01-01

Sporulation in the Gram-positive bacterium, Bacillus subtilis, has been used as an excellent model system to study cell differentiation for almost half a century. This research has given us a detailed picture of the genetic, physiological and biochemical mechanisms that allow bacteria to survive harsh environmental conditions by forming highly robust spores. Although many basic aspects of this process are now understood in great detail, including the crystal and NMR structures of some of the key proteins and their complexes, bacterial sporulation still continues to be a highly attractive model for studying various cell processes at a molecular level. There are several reasons for such scientific interest. First, some of the complex steps in sporulation are not fully understood and/or are only described by 'controversial' models. Second, intensive research on unicellular development of a single microorganism, B. subtilis, left us largely unaware of the multitude of diverse sporulation mechanisms in many other Gram-positive endospore and exospore formers. This diversity would likely be increased if we were to include sporulation processes in the Gram-negative spore formers. Spore formers have great potential in applied research. They have been used for many years as biodosimeters and as natural insecticides, exploited in the industrial production of enzymes, antibiotics, used as probiotics and, more, exploited as possible vectors for drug delivery, vaccine antigens and other immunomodulating molecules. This report describes these and other aspects of current fundamental and applied spore research that were presented at European Spores Conference held in Smolenice Castle, Slovakia, June 2004.

Fundamental properties of resonances

PubMed Central

Ceci, S.; Hadžimehmedović, M.; Osmanović, H.; Percan, A.; Zauner, B.

2017-01-01

All resonances, from hydrogen nuclei excited by the high-energy gamma rays in deep space to newly discovered particles produced in Large Hadron Collider, should be described by the same fundamental physical quantities. However, two distinct sets of properties are used to describe resonances: the pole parameters (complex pole position and residue) and the Breit-Wigner parameters (mass, width, and branching fractions). There is an ongoing decades-old debate on which one of them should be abandoned. In this study of nucleon resonances appearing in the elastic pion-nucleon scattering we discover an intricate interplay of the parameters from both sets, and realize that neither set is completely independent or fundamental on its own. PMID:28345595

On the Contributions to the Materials Science Aspects of Phosphazene Chemistry by Professor Christopher W. Allen: The One-Pot Synthesis of Linear Polyphosphazenes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eric S. Peterson; Thomas A. Luther; Mason K. Harrup

2007-06-01

The wide range of applications for the phosphazene compounds has stimulated a major research effort involving several industrial, academic, and national laboratories over the past 40 years. One of Professor Allen’s research areas was to establish fundamental synthetic methods for the commercial preparation of phosphazene polymers, investigate their properties, and develop useful products. In this paper we review some of the materials science aspects of Professor Allen’s research including recent advances on the preparation and polymerization of Cl3PNP(O)Cl2. This work, in particular, has led to a route for the “one-pot” synthesis of stable linear poly(organophosphazenes) as demonstrated through the formationmore » of poly[bis-(2-methoxyethoxyethoxy)phosphazene] (MEEP) and a phosphazene heteropolymer (HPP) containing a balance of hydrophilic and hydrophobic components that allow for control and molecular affinities.« less

Mastery of Fundamental Movement Skills among 6-Year-Old Flemish Pre-School Children

ERIC Educational Resources Information Center

Vandaele, Bart; Cools, Wouter; de Decker, Steve; de Martelaer, Kristine

2011-01-01

The purpose of this study was to assess mastery of Fundamental Movement Skills (FMS) in 6- to 6.5-year-old Flemish pre-school children. The subjects were 236 6-year-old children (138 boys, 98 girls; mean age 6 years 2.4 months, SD 2.4). Children were individually assessed with the Motoriktest fur Vier- bis Sechsjahrige Kinder (MOT 4-6) in four…

Methodology for Selection of Optimum Light Stringers in Functionally Graded Panels Designed for Prescribed Fundamental Frequency or Buckling Load

NASA Astrophysics Data System (ADS)

Birman, Victor; Byrd, Larry W.

2008-02-01

The interest to functionally graded materials (FGM) and structures has been generated by their potential advantages, including enhanced thermal properties, reduced or eliminated delamination concerns, a potential for an improved stress distribution, etc. Various aspects of the processing, design, micromechanics and analysis of FGM have been outlined in a number of reviews, mentioned here are [1-3]. In particular, functionally graded panels may be advantageous compared to their conventional counterparts in numerous applications. However, a typical FGM panel is asymmetric about its middle plane resulting in lower buckling loads and fundamental frequencies as well as higher stresses and deformations than the counterpart with a symmetric distribution of the same constituents. The reduced stiffness of FGM panels can be compensated by reinforcing them with stringers. For example, metallic stringers at the metal-rich surface of a FGM ceramic-metal panel may provide an efficient solution enabling a designer to increase both buckling loads as well as natural frequencies. The list of studies on optimization of FGM is extensive as could be anticipated for such tailored structural elements. For example, recent papers by Batra and his collaborators present optimization of the natural frequencies of a FGM plate through material grading [4] and through the graded fiber orientation [5]. The present paper is concerned with an optimum design of the system of stringers for a specified FGM panel. The task is to design the lightest system of stringers enabling the panel to achieve prescribed buckling loads or fundamental frequency.

Can Boredom Educate Us? Tracing a Mood in Heidegger's Fundamental Ontology from an Educational Point of View

ERIC Educational Resources Information Center

Mansikka, Jan-Erik

2009-01-01

Martin Heidegger (1989-1976) was convinced that we can learn something about the way we inhabit the world by turning attention to our fundamental moods. It was one important theme of his fundamental ontology in the 1920s. There is, according to Heidegger, an intricate connection between awakening our moods and developing a reflexive stance. He…

Solution-processable glass LiI-Li 4SnS 4 superionic conductors for all-solid-state Li-ion batteries

DOE PAGES

Kern Ho Park; Oh, Dae Yang; Choi, Young Eun; ...

2015-12-22

The new, highly conductive (4.1 × 10 –4 S cm –1 at 30 °C), highly deformable, and dry-air-stable glass 0.4LiI-0.6Li 4SnS 4 is prepared using a homogeneous methanol solution. Furthermore, the solution process enables the wetting of any exposed surface of the active materials with highly conductive solidified electrolytes (0.4LiI-0.6Li 4SnS 4), resulting in considerable improvements in electrochemical performances of these electrodes over conventional mixture electrodes.

Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR

PubMed Central

Crack, Jason C.; Thomson, Andrew J.

2017-01-01

The iron-sulfur cluster containing protein Fumarate and Nitrate Reduction (FNR) is the master regulator for the switch between anaerobic and aerobic respiration in Escherichia coli and many other bacteria. The [4Fe-4S] cluster functions as the sensory module, undergoing reaction with O2 that leads to conversion to a [2Fe-2S] form with loss of high-affinity DNA binding. Here, we report studies of the FNR cluster conversion reaction using time-resolved electrospray ionization mass spectrometry. The data provide insight into the reaction, permitting the detection of cluster conversion intermediates and products, including a [3Fe-3S] cluster and persulfide-coordinated [2Fe-2S] clusters [[2Fe-2S](S)n, where n = 1 or 2]. Analysis of kinetic data revealed a branched mechanism in which cluster sulfide oxidation occurs in parallel with cluster conversion and not as a subsequent, secondary reaction to generate [2Fe-2S](S)n species. This methodology shows great potential for broad application to studies of protein cofactor–small molecule interactions. PMID:28373574

Canada-U.S. Relations

DTIC Science & Technology

2009-05-12

56 RBC Financial Group, Daily Forex Fundamentals, February 27, 2009. [ http...www.actionforex.com/fundamental- analysis/daily- forex -fundamentals/canada%27s-fourth%11quarter-current-account-moves-into-deficit-after-nine-years- of-surpluses...sharing, infrastructure improvements, improvement of compatible immigration databases , visa policy coordination, common biometric identifiers in

Stability studies of As4S4 nanosuspension prepared by wet milling in Poloxamer 407.

PubMed

Bujňáková, Zdenka; Dutková, Erika; Baláž, Matej; Turianicová, Erika; Baláž, Peter

2015-01-15

In this paper the stability of the arsenic sulfide (As4S4) nanosuspension prepared by wet milling in a circulation mill in the environment of copolymer Poloxamer 407 was studied. The obtained As4S4 particles in nanosuspension were of ∼ 100 nm in size. The influence of temperature and UV irradiation on the changes in physical and/or chemical properties was followed. Long-term stability was observed via particle size distribution and zeta potential measurements. Influence of UV irradiation was studied via UV-vis spectroscopy (UV-vis), photoluminicsence (PL) technique and Fourier transform infrared spectroscopy (FTIR) measurements. The best stability of the nanosuspension (24 weeks) was achieved when stored at 4°C and in the dark. Copyright © 2014 Elsevier B.V. All rights reserved.

Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation

PubMed Central

2017-01-01

Nature utilizes [FeFe]-hydrogenase enzymes to catalyze the interconversion between H2 and protons and electrons. Catalysis occurs at the H-cluster, a carbon monoxide-, cyanide-, and dithiomethylamine-coordinated 2Fe subcluster bridged via a cysteine to a [4Fe-4S] cluster. Biosynthesis of this unique metallocofactor is accomplished by three maturase enzymes denoted HydE, HydF, and HydG. HydE and HydG belong to the radical S-adenosylmethionine superfamily of enzymes and synthesize the nonprotein ligands of the H-cluster. These enzymes interact with HydF, a GTPase that acts as a scaffold or carrier protein during 2Fe subcluster assembly. Prior characterization of HydF demonstrated the protein exists in both dimeric and tetrameric states and coordinates both [4Fe-4S]2+/+ and [2Fe-2S]2+/+ clusters [Shepard, E. M., Byer, A. S., Betz, J. N., Peters, J. W., and Broderick, J. B. (2016) Biochemistry 55, 3514–3527]. Herein, electron paramagnetic resonance (EPR) is utilized to characterize the [2Fe-2S]+ and [4Fe-4S]+ clusters bound to HydF. Examination of spin relaxation times using pulsed EPR in HydF samples exhibiting both [4Fe-4S]+ and [2Fe-2S]+ cluster EPR signals supports a model in which the two cluster types either are bound to widely separated sites on HydF or are not simultaneously bound to a single HydF species. Gel filtration chromatographic analyses of HydF spectroscopic samples strongly suggest the [2Fe-2S]+ and [4Fe-4S]+ clusters are coordinated to the dimeric form of the protein. Lastly, we examined the 2Fe subcluster-loaded form of HydF and showed the dimeric state is responsible for [FeFe]-hydrogenase activation. Together, the results indicate a specific role for the HydF dimer in the H-cluster biosynthesis pathway. PMID:28525271

Communication: Fitting potential energy surfaces with fundamental invariant neural network