Sample records for sabril vigabatrin advisory

  1. Which children receive vigabatrin? Characteristics of pediatric patients enrolled in the mandatory FDA registry.

    PubMed

    Pellock, John M; Faught, Edward; Foroozan, Rod; Sergott, Robert C; Shields, W Donald; Ziemann, Adam; Lee, Deborah; Dribinsky, Yekaterina; Torri, Sarah; Othman, Feisal; Isojarvi, Jouko

    2016-07-01

    Vigabatrin (Sabril®) is an antiepileptic drug (AED) currently indicated in the US as a monotherapy for patients 1month to 2years of age with infantile spasms (IS) and as adjunctive therapy for patients ≥10years of age with refractory complex partial seizures (rCPS) whose seizures have inadequately responded to several alternative treatments and for whom the potential benefits outweigh the risk of vision loss. The approval required an FDA mandated registry. This article describes 5years of demographic and treatment exposure data from US pediatric patients (<17years). Participation is mandatory for all US Sabril® prescribers and patients. A benefit-risk assessment must be documented for patient progression to maintenance therapy. This includes demographic diagnosis and reports of ophthalmologic assessments (where available). Patient data were grouped by age as proxies for indication (IS: <3years, rCPS: ≥3 to <17years). As of August 26, 2014, 5546/6823 enrolled patients were pediatric/total; 4472 (81%) were vigabatrin-naïve. Seventy-one percent of patients were <3years of age; 29% were ≥3 to <17years of age. Etiologies of IS were identified as cryptogenic (21%), symptomatic tuberous sclerosis (17%), and symptomatic other (42%). The majority of patients with IS (56%) attempted no prior treatments; 16% received adrenocorticotropic hormone prior to vigabatrin. A third of patients with IS were receiving 1 concomitant treatment with vigabatrin. For patients with rCPS, 39% attempted 1-3 prior treatments; 27% were receiving 2 concomitant treatments at enrollment. A total of 1852 (41%) patients did not undergo baseline ophthalmological assessment; 25% of patients with IS and 42% of patients with rCPS were exempted for neurologic disabilities. Kaplan-Meier estimates predict that 71% and 65% of vigabatrin-naïve patients with IS and rCPS, respectively, would remain in the registry at 6months. Most pediatric vigabatrin patients have IS as an underlying diagnosis

  2. Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin

    PubMed Central

    Juncosa, Jose I.; Groves, Andrew P.; Xia, Guoyao; Silverman, Richard B.

    2012-01-01

    We have synthesized three analogues of 4-amino-5-fluorohexanoic acids as potential inactivators of γ-aminobutyric acid aminotransferase (GABA-AT), which were designed to combine the potency of their shorter chain analogue, 4-amino-5-fluoropentanoic acid (AFPA), with the greater enzyme selectivity of the antiepileptic vigabatrin (Sabril®). Unexpectedly, these compounds failed to inactivate or inhibit the enzyme, even at high concentrations. On the basis of molecular modeling studies, we propose that the GABA-AT active site has an accessory binding pocket that accommodates the vinyl group of vigabatrin and the fluoromethyl group of AFPA, but is too narrow to support the extra width of one distal methyl group in the synthesized analogues. PMID:23306054

  3. Determination of GABA and vigabatrin in human plasma by a rapid and simple HPLC method: correlation between clinical response to vigabatrin and increase in plasma GABA.

    PubMed

    Löscher, W; Fassbender, C P; Gram, L; Gramer, M; Hörstermann, D; Zahner, B; Stefan, H

    1993-03-01

    The novel antiepileptic drug vigabatrin (Sabril) acts by inhibiting degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), increasing the GABA concentrations in the brain. Because the GABA degrading enzyme GABA aminotransferase (GABA-T) is also present in peripheral tissues, including blood platelets, measurement of plasma GABA levels might be a useful indication of the pharmacological response to vigabatrin during therapeutic monitoring. However, because of the very low concentrations of GABA in plasma, the few methods available for plasma GABA analysis are time-consuming, difficult to perform and/or not selective enough because of potential interference with other plasma constituents. In the present study, a rapid, selective and sensitive amino acid analysis HPLC method has been developed for plasma GABA determination with fluorescence detection, using o-phthaldialdehyde as a precolumn derivatizing agent. By employing a 3 microns particle size reversed-phase column and a multi-step gradient system of two solvents, the very low endogenous concentration of GABA in human plasma could be reproducibly quantitated without interference of other endogenous compounds. Incubation of human plasma samples with GABA degrading enzyme(s) resulted in an almost total loss of the GABA peak, thus demonstrating the specificity of the method for GABA analysis. In addition to GABA and other endogenous amino acids, the HPLC method could be used to quantitate plasma levels of vigabatrin. Thus, this improved HPLC amino acid assay might be used to examine whether concomitant monitoring of plasma GABA and vigabatrin is useful for clinical purposes. This was examined in 20 epileptic patients undergoing chronic treatment with vigabatrin. The average plasma GABA level of these 20 patients did not differ significantly from non-epileptic controls. However, when epileptic patients were subdivided according to their clinical response to vigabatrin, vigabatrin responders

  4. Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid

    DOEpatents

    Silverman, Richard B; Dewey, Stephen L; Miller, Steven

    2015-03-03

    (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).

  5. Vigabatrin

    MedlinePlus

    Vigabatrin tablets are used in combination with other medications to control certain types of seizures in adults and children ... changes in pictures of the brain taken by magnetic resonance imaging (MRI). These changes were not seen in older ...

  6. Fluorescent high-performance liquid chromatographic analysis of vigabatrin enantiomers after derivatizing with naproxen acyl chloride.

    PubMed

    Hsieh, Chun-Yu; Wang, Shing-Yaw; Kwan, Aij-Lie; Wu, Hsin-Lung

    2008-01-18

    Vigabatrin is widely used as an anticonvulsant in the treatment of seizures. Vigabatrin is usually supplied as racemate in formulation, but only the (S)-(+)-enantiomer of vigabatrin is pharmacologically active. A simple and sensitive liquid chromatographic method is described for the separation and quantification of vigabatrin enantiomers. The method is based on derivatizing racemic vigabatrin with a fluorescent chiral reagent (naproxen acyl chloride). The resulting diastereomeric derivatives are highly responsive to a fluorimetric detector (lambda(ex)=230 nm, lambda(em)=350 nm). The lower quantitation limit of the method is attainable at 25 nM for (S)-(+)-vigabatrin or (R)-(-)-vigabatrin with a detection limit of about 2.5 nM (S/N=3 with 10 microl injected). Application of the method to the analysis of vigabatrin in serum of dosed patients proved feasible.

  7. Changes in plasma GABA concentration during vigabatrin treatment of epilepsy: a prospective study.

    PubMed

    Erdal, J; Gram, L; Alving, J; Löscher, W

    1999-04-01

    The aim of the present prospective study was to evaluate changes in plasma GABA concentration in relation to clinical response during vigabatrin treatment of epilepsy. We studied 29 patients with uncontrolled partial-onset seizures during open add-on vigabatrin treatment and measured plasma GABA and vigabatrin concentrations by a sensitive HPLC method. Following short-term treatment 17 out of 28 patients had a seizure reduction of > 50% (responders). After long-term treatment 16 out of 22 patients were responders. There was no difference between responders and nonresponders regarding pretreatment seizure frequency, treatment duration, vigabatrin dose, or plasma vigabatrin concentration. Responders had a significant (p < 0.001) increase in mean plasma GABA both after short-term (from 0.380 to 0.530 nmol/ml; mean increase: 48%) and after long-term (from 0.392 to 0.618 nmol/ml; mean increase: 71%) vigabatrin treatment, whilst nonresponders had no significant changes in GABA levels. However, since plasma GABA increased in a subgroup of nonresponders, mean plasma GABA levels did not differ between responders and nonresponders. Although plasma GABA increased significantly in the responder but not in the nonresponder group during vigabatrin treatment of patients with epilepsy, it does not seem to be a reliable marker of individual clinical response to vigabatrin treatment.

  8. Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.

    PubMed Central

    Nøhr, Martha Kampp; Thale, Zia I; Brodin, Birger; Hansen, Steen H; Holm, René; Nielsen, Carsten Uhd

    2014-01-01

    Vigabatrin is an antiepileptic drug substance mainly used in pediatric treatment of infantile spasms. The main source of nutrition for infants is breast milk and/or infant formula. Our hypothesis was that infant formula may affect the intestinal absorption of vigabatrin. The aim was therefore to investigate the potential effect of coadministration of infant formula with vigabatrin on the oral absorption in vitro and in vivo. The effect of vigabatrin given with an infant formula on the oral uptake and transepithelial transport was investigated in vitro in Caco-2 cells. In vivo effects of infant formula and selected amino acids on the pharmacokinetic profile of vigabatrin was investigated after oral coadministration to male Sprague–Dawley rats using acetaminophen as a marker for gastric emptying. The presence of infant formula significantly reduced the uptake rate and permeability of vigabatrin in Caco-2 cells. Oral coadministration of vigabatrin and infant formula significantly reduced Cmax and prolonged tmax of vigabatrin absorption. Ligands for the proton-coupled amino acid transporter PAT1, sarcosine, and proline/l-tryptophan had similar effects on the pharmacokinetic profile of vigabatrin. The infant formula decreased the rate of gastric emptying. Here we provide experimental evidence for an in vivo role of PAT1 in the intestinal absorption of vigabatrin. The effect of infant formula on the oral absorption of vigabatrin was found to be due to delayed gastric emptying, however, it seems reasonable that infant formula may also directly affect the intestinal absorption rate of vigabatrin possibly via PAT1. PMID:25505585

  9. An investigation into the relationship between vigabatrin, movement disorders, and brain magnetic resonance imaging abnormalities in children with infantile spasms.

    PubMed

    Fong, Choong Yi; Osborne, John P; Edwards, Stuart W; Hemingway, Cheryl; Hancock, Eleanor; Johnson, Anthony L; Kennedy, Colin R; Kneen, Rachel; Likeman, Marcus; Lux, Andrew L; Mordekar, Santosh R; Murugan, Velayutham; Newton, Richard W; Pike, Michael; Quinn, Michael; Spinty, Stefan; Vassallo, Grace; Verity, Christopher M; Whitney, Andrea; O'Callaghan, Finbar J K

    2013-09-01

    We aimed to investigate the relationship between movement disorders, changes on brain magnetic resonance imaging (MRI), and vigabatrin therapy in children with infantile spasms. Retrospective review and brain MRI analysis of children enrolled in the International Collaborative Infantile Spasms Study (ICISS) who developed a movement disorder on vigabatrin therapy. Comparisons were made with controls within ICISS who had no movement disorder. Ten of 124 infants had a movement disorder and in eight it had developed on vigabatrin therapy. Two had a movement disorder that resolved on dose-reduction of vigabatrin, one had improvement on withdrawing vigabatrin, two had resolution without any dose change, and in three it persisted despite vigabatrin withdrawal. The typical brain MRI changes associated with vigabatrin therapy were noted in two infants. Ten control infants were identified. Typical MRI changes noted with vigabatrin were noted in three controls. It is possible that in two out of eight cases, vigabatrin was associated with the development of a movement disorder. In six out of eight cases a causal relationship was less plausible. The majority of infants treated with vigabatrin did not develop a movement disorder. MRI changes associated with vigabatrin do not appear to be specifically related to the movement disorder. © 2013 Mac Keith Press.

  10. Effect of vigabatrin on sedation and cognitive function in patients with refractory epilepsy.

    PubMed Central

    Gillham, R A; Blacklaw, J; McKee, P J; Brodie, M J

    1993-01-01

    Twenty-four patients with refractory epilepsy on one or more antiepileptic drugs were given additional vigabatrin (1 g twice daily for six weeks, followed by 1.5 g twice daily for a further six weeks) and matched placebo in a double blind, randomised, crossover study. A battery of neuropsychological tests was administered at baseline and at weeks two, six and 12 of both treatment periods. No significant differences were found between vigabatrin and placebo at any time point for any of the objective tests of cognitive function. Patients, however, reported a greater degree of sedation after two and six weeks on vigabatrin than during the equivalent placebo phase (p < 0.01), although no such difference was apparent at 12 weeks. Follow up over a mean of 14.75 months in 12 responders, who continued on vigabatrin, revealed a significant improvement (all p < 0.01) on each of three composite scales (three psychomotor tests, four memory tests, three self rating scales) compared with their scores during the double blind trial. Vigabatrin did not cause cognitive impairment either acutely or in the long term. Phased introduction, however, seems a prudent policy to allow tolerance to early subjective sedation. PMID:8270925

  11. The relationship between hippocampal EEG theta activity and locomotor behaviour in freely moving rats: effects of vigabatrin.

    PubMed

    Bouwman, B M; van Lier, H; Nitert, H E J; Drinkenburg, W H I M; Coenen, A M L; van Rijn, C M

    2005-01-30

    The relationship between hippocampal electroencephalogram (EEG) theta activity and locomotor speed in both spontaneous and forced walking conditions was studied in rats after vigabatrin injection (500 mg/kg i.p.). Vigabatrin increased the percentage of time that rats spent being immobile. During spontaneous walking in the open field, the speed of locomotion was increased by vigabatrin, while theta peak frequency was decreased. Vigabatrin also reduced the theta peak frequency during forced (speed controlled) walking. There was only a weak positive correlation (r=0.22) between theta peak frequency and locomotor speed for the saline condition. Furthermore, vigabatrin abolishes the weak relationship between speed of locomotion and theta peak frequency. Vigabatrin and saline did not differ in the slope of the regression line, but showed different offset points at the theta peak frequency axis. Thus, other factors than speed of locomotion seem to be involved in determination of the theta peak frequency.

  12. RP-HPLC method for simultaneous estimation of vigabatrin, gamma-aminobutyric acid and taurine in biological samples.

    PubMed

    Police, Anitha; Shankar, Vijay Kumar; Narasimha Murthy, S

    2018-02-15

    Vigabatrin is used as first line drug in treatment of infantile spasms for its potential benefit overweighing risk of causing permanent peripheral visual field defects and retinal damage. Chronic administration of vigabatrin in rats has demonstrated these ocular events are result of GABA accumulation and depletion of taurine levels in retinal tissues. In vigabatrin clinical studies taurine plasma level is considered as biomarker for studying structure and function of retina. The analytical method is essential to monitor taurine levels along with vigabatrin and GABA. A RP-HPLC method has been developed and validated for simultaneous estimation of vigabatrin, GABA and taurine using surrogate matrix. Analytes were extracted from human plasma, rat plasma, retina and brain by simple protein precipitation method and derivatized by naphthalene 2, 3‑dicarboxaldehyde to produce stable fluorescent active isoindole derivatives. The chromatographic analysis was performed on Zorbax Eclipse AAA column using gradient elution profile and eluent was monitored using fluorescence detector. A linear plot of calibration curve was observed in concentration range of 64.6 to 6458, 51.5 to 5150 and 62.5 to 6258 ng/mL for vigabatrin, GABA and taurine, respectively with r 2  ≥ 0.997 for all analytes. The method was successfully applied for estimating levels of vigabatrin and its modulator effect on GABA and taurine levels in rat plasma, brain and retinal tissue. This RP-HPLC method can be applied in clinical and preclinical studies to explore the effect of taurine deficiency and to investigate novel approaches for alleviating vigabatrin induced ocular toxicity. Copyright © 2018. Published by Elsevier B.V.

  13. Vigabatrin, a GABA Transaminase Inhibitor, Reversibly Eliminates Tinnitus in an Animal Model

    PubMed Central

    Spires, T. JosephD.; Bauer, Carol A.

    2007-01-01

    Animal models have facilitated basic neuroscience research investigating the pathophysiology of tinnitus. It has been hypothesized that partial deafferentation produces a loss of tonic inhibition in the auditory system that may lead to inappropriate neuroplastic changes eventually expressed as tinnitus. The pathological down-regulation of γ-amino butyric acid (GABA) provides a potential mechanism for this loss of inhibition. Using an animal model previously demonstrated to be sensitive to treatments that either induce or attenuate tinnitus, the present study examined the effect of the specific GABA agonist vigabatrin on chronic tinnitus. It was hypothesized that vigabatrin would decrease the evidence of tinnitus by restoring central inhibitory function through increased GABA availability. Vigabatrin has been demonstrated to elevate central GABA levels (Mattson et al. 1995). Tinnitus was induced in rats using a single 1-h unilateral exposure to band-limited noise, which preserved normal hearing in one ear. Psychophysical evidence of tinnitus was obtained using a free-operant conditioned-suppression method: Rats lever-pressed for food pellets and were trained to discriminate between the presence and absence of sound by punishing lever pressing with a mild foot shock (0.5 mA; 1 s) at the conclusion of randomly introduced silent periods (60 s) inserted into background low-level noise. Additional random insertion of pure tone and noise periods of variable intensity enabled the derivation of psychophysical functions that reflected the presence of tinnitus with features similar to 20-kHz tones. Vigabatrin was chronically administered via drinking water at 30 and 81 mg kg−1 day−1, with each dose level tested over 2 weeks, followed by a 0-mg washout test. Vigabatrin completely and reversibly eliminated the psychophysical evidence of tinnitus at both doses. Although vigabatrin has serious negative side effects that have prevented its clinical use in the USA, it is

  14. Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms

    PubMed Central

    Lerner, Jason T; Salamon, Noriko; Sankar, Raman

    2010-01-01

    Vigabatrin, the first therapeutic agent to be approved by the Food and Drug Administration for the treatment of infantile spasms, as well as for adjunctive use in the treatment of refractory complex partial epilepsy, represents an important advance for patients with difficult-to-manage epilepsy. This review summarizes the complex history, chemistry, and pharmacology, as well as the clinical data leading to the approval of vigabatrin for infantile spasms in the US. The long path to its approval reflects the visual system and white matter toxicity concerns with this agent. This review provides a brief description of these concerns, and the regulatory safety monitoring and mitigation systems that have been put in place to enhance benefit over risk. PMID:21127692

  15. Population dose-response analysis of daily seizure count following vigabatrin therapy in adult and pediatric patients with refractory complex partial seizures.

    PubMed

    Nielsen, Jace C; Hutmacher, Matthew M; Wesche, David L; Tolbert, Dwain; Patel, Mahlaqa; Kowalski, Kenneth G

    2015-01-01

    Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an adjunctive therapy for adult patients with refractory complex partial seizures (rCPS). The purpose of this investigation was to describe the relationship between vigabatrin dosage and daily seizure rate for adults and children with rCPS and identify relevant covariates that might impact seizure frequency. This population dose-response analysis used seizure-count data from three pediatric and two adult randomized controlled studies of rCPS patients. A negative binomial distribution model adequately described daily seizure data. Mean seizure rate decreased with time after first dose and was described using an asymptotic model. Vigabatrin drug effects were best characterized by a quadratic model using normalized dosage as the exposure metric. Normalized dosage was an estimated parameter that allowed for individualized changes in vigabatrin exposure based on body weight. Baseline seizure rate increased with decreasing age, but age had no impact on vigabatrin drug effects after dosage was normalized for body weight differences. Posterior predictive checks indicated the final model was capable of simulating data consistent with observed daily seizure counts. Total normalized vigabatrin dosages of 1, 3, and 6 g/day were predicted to reduce seizure rates 23.2%, 45.6%, and 48.5%, respectively. © 2014, The American College of Clinical Pharmacology.

  16. A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum.

    PubMed

    Ratnaraj, N; Patsalos, P N

    1998-08-01

    A gradient high-performance liquid chromatography micromethod is described for the simultaneous quantitation of vigabatrin and gabapentin in human serum. Chromatography was performed using a 125- x 3-mm ID Hypersil BDS C-18 column with a 3-microm mini-bore, eluted with a gradient system comprised of phosphate buffer (pH 6.5)-acetonitrile-methanol-water at a flow rate of 0.45 ml/minute. The column eluent was monitored on a fluorescence detector using excitation and emission wavelengths of 340 and 440 nm, respectively. The lower limit of quantitation for vigabatrin and for gabapentin was 5 micromol/l, and the within-batch and between-batch coefficients of variation were <5%. No interference from commonly prescribed antiepileptic drugs (carbamazepine and its metabolite carbamazepine epoxide, oxcarbazepine and its metabolite 10-hydroxycarbazepine, ethosuximide, lamotrigine, phenobarbitone, phenytoin, primidone, and valproic acid) was observed; thus, the method can be used to monitor vigabatrin and gabapentin in patients on polytherapy antiepileptic drug regimens.

  17. Determination of vigabatrin in plasma by reversed-phase high-performance liquid chromatography.

    PubMed

    Tsanaclis, L M; Wicks, J; Williams, J; Richens, A

    1991-05-01

    A method is described for the determination of vigabatrin in 50 microliters of plasma by isocratic high-performance liquid chromatography using fluorescence detection. The procedure involves protein precipitation with methanol followed by precolumn derivatisation with o-phthaldialdehyde reagent. Separation of the derivatised vigabatrin was achieved on a Microsorb C18 column using a mobile phase of 10 mM orthophosphoric acid:acetonitrile:methanol (6:3:1) at a flow rate of 2.0 ml/min. Assay time is 15 min and chromatograms show no interference from commonly coadministered anticonvulsant drugs. The total analytical error within the range of 0.85-85 micrograms/ml was found to be 7.6% with the within-replicates error of 2.76%. The minimum detection limit was 0.08 micrograms/ml and the minimum quantitation limit was 0.54 micrograms/ml.

  18. Vigabatrin in dried plasma spots: validation of a novel LC-MS/MS method and application to clinical practice.

    PubMed

    Kostić, Nađa; Dotsikas, Yannis; Jović, Nebojša; Stevanović, Galina; Malenović, Anđelija; Medenica, Mirjana

    2014-07-01

    This paper presents a LC-MS/MS method for the determination of antiepileptic drug vigabatrin in dried plasma spots (DPS). Due to its zwitterionic chemical structure, a pre-column derivatization procedure was performed, aiming to yield enhanced ionization efficiency and improved chromatographic behaviour. Propyl chloroformate, in the presence of propanol, was selected as the best derivatization reagent, providing a strong signal along with reasonable run time. A relatively novel sample collection technique, DPS, was utilized, offering easy sample handling and analysis, using a sample in micro amount (∼5μL). Derivatized vigabatrin and its internal standard, 4-aminocyclohexanecarboxylic acid, were extracted by liquid-liquid extraction (LLE) and determined in positive ion mode by applying two SRM transitions per analyte. A Zorbax Eclipse XDB-C8 column (150×4.6mm, 5μm particle size) maintained at 30°C, was utilized with running mobile phase composed of acetonitrile: 0.15% formic acid (85:15, v/v). Flow rate was 550μL/min and total run time 4.5min. The assay exhibited excellent linearity over the concentration range of 0.500-50.0μg/mL, which is suitable for the determination of vigabatrin level after per os administration in children and youths with epilepsy, who were on vigabatrin therapy, with or without co-medication. Specificity, accuracy, precision, recovery, matrix-effect and stability were also estimated and assessed within acceptance criteria. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1

    PubMed Central

    Abbot, Emily L; Grenade, Danielle S; Kennedy, David J; Gatfield, Kelly M; Thwaites, David T

    2005-01-01

    The aim of this investigation was to determine if the human proton-coupled amino-acid transporter 1 (hPAT1 or SLC36A1) is responsible for the intestinal uptake of the orally-administered antiepileptic agent 4-amino-5-hexanoic acid (vigabatrin). The Caco-2 cell line was used as a model of the human small intestinal epithelium. Competition experiments demonstrate that [3H]GABA uptake across the apical membrane was inhibited by vigabatrin and the GABA analogues trans-4-aminocrotonic acid (TACA) and guvacine, whereas 1-(aminomethyl)cyclohexaneacetic acid (gabapentin) had no affect. Experiments with 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF)-loaded Caco-2 cells demonstrate that apical exposure to vigabatrin and TACA induce comparable levels of intracellular acidification (due to H+/amino-acid symport) to that generated by GABA, suggesting that they are substrates for a H+-coupled absorptive transporter such as hPAT1. In hPAT1 and mPAT1-expressing Xenopus laevis oocytes [3H]GABA uptake was inhibited by vigabatrin, TACA and guvacine, whereas gabapentin failed to inhibit [3H]GABA uptake. In Na+-free conditions, vigabatrin and TACA evoked similar current responses (due to H+/amino-acid symport) in hPAT1-expressing oocytes under voltage-clamp conditions to that induced by GABA (whereas no current was observed in water-injected oocytes) consistent with the ability of these GABA analogues to inhibit [3H]GABA uptake. This study demonstrates that hPAT1 is the carrier responsible for the uptake of vigabatrin across the brush-border membrane of the small intestine and emphasises the therapeutic potential of hPAT1 as a delivery route for orally administered, clinically significant GABA-related compounds. PMID:16331283

  20. High-performance liquid chromatographic analysis of vigabatrin enantiomers in human serum by precolumn derivatization with o-phthaldialdehyde-N-acetyl-L-cysteine and fluorescence detection.

    PubMed

    Vermeij, T A; Edelbroek, P M

    1998-09-25

    A rapid and simple method is presented for the determination of vigabatrin enantiomers in human serum by high-performance liquid chromatography. Serum is deproteinized with trichloroacetic acid and aliquots of the supernatant are precolumn derivatized with o-phthaldialdehyde and N-acetyl-L-cysteine, resulting in the formation of diastereomeric isoindoles. Separation was achieved on a Spherisorb 3ODS2 column using a gradient solvent program and the column eluent is monitored using fluorescence detection. L-Homoarginine was used as an internal standard. Within-day precisions (C.V.; n=8) were 2.8 and 1.1%, respectively, for the (R)-(-)- and (S)-(+)-enantiomer in serum containing 15.4 mg/l (RS)-vigabatrin. The method was linear in the 0-45 mg/l range for both enantiomers and the minimum quantitation limit was 0.20 mg/l for (R)-(-)-vigabatrin and 0.14 mg/l for (S)-(+)-vigabatrin. No interferences were found from commonly co-administered antiepileptic drugs and from endogenous amino acids. The method is suitable for routine therapeutic drug monitoring and for pharmacokinetic studies.

  1. Vigabatrin pediatric dosing information for refractory complex partial seizures: results from a population dose-response analysis.

    PubMed

    Nielsen, Jace C; Tolbert, Dwain; Patel, Mahlaqa; Kowalski, Kenneth G; Wesche, David L

    2014-12-01

    We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures (rCPS) that would produce efficacy comparable to that observed for approved adult dosages. A dose-response model related seizure-count data to vigabatrin dosage to identify dosages for pediatric rCPS patients. Seizure-count data were obtained from three pediatric and two adult rCPS clinical trials. Dosages were predicted for oral solution and tablet formulations. Predicted oral solution dosages to achieve efficacy comparable to that of a 1 g/day adult dosage were 350 and 450 mg/day for patients with body weight ranges 10-15 and >15-20 kg, respectively. Predicted oral solution dosages for efficacy comparable to a 3 g/day adult dosage were 1,050 and 1,300 mg/day for weight ranges 10-15 and >15-20 kg, respectively. Predicted tablet dosage for efficacy comparable to a 1 g/day adult dosage was 500 mg/day for weight ranges 25-60 kg. Predicted tablet dosage for efficacy comparable to a 3 g/day adult dosage was 2,000 mg for weight ranges 25-60 kg. Vigabatrin dosages were identified for pediatric rCPS patients with body weights ≥10 kg. Wiley Periodicals, Inc. © 2014 International League Against Epilepsy.

  2. Determination of enantiomeric vigabatrin by derivatization with diacetyl-l-tartaric anhydride followed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry.

    PubMed

    Zhao, Jing; Shin, Yujin; Jin, Yan; Jeong, Kyung Min; Lee, Jeongmi

    2017-01-01

    Vigabatrin, one of the most widely used antiepileptic drugs, is marketed and administered as a racemic mixture, while only S-enantiomer is therapeutically effective. In the present study, diacetyl-l-tartaric acid anhydride was used as an inexpensive and effective chiral derivatization reagent to produce tartaric acid monoester derivatives of vigabatrin enantiomers that could be readily resolved by reversed phase chromatography. Derivatization conditions were statistically optimized by response surface methodology, resulting in an optimal reaction temperature of 44°C and an optimal reaction time of 30min. The derivatized diastereomers of vigabatrin and internal standard (gabapentin) were analyzed using ultra-high performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry. For this analysis, an Agilent ZORBAX Rapid Resolution High Definition Eclipse Plus C18 column (100mm×2.1mm, 1.8μm) was employed for chromatographic separation using 10mM ammonium formate (pH 3.0) and methanol as mobile phase at a flow rate of 0.2mLmin -1 . The established method was validated in terms of specificity, linearity, precision, accuracy, dilution integrity, recovery, matrix effect, stability, and incurred sample reanalysis. It was linear over a range of 0.25-100.0mgL -1 for both S- and R-enantiomers (R 2 ≥0.9987 for both). Intra- and inter-day precisions and accuracies were within acceptable ranges. The method was successfully applied to determine the levels of vigabatrin enantiomers in mouse serum after administration of vigabatrin racemate. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Determination of vigabatrin in human plasma and urine by high-performance liquid chromatography with fluorescence detection.

    PubMed

    Erturk, S; Aktas, E S; Atmaca, S

    2001-09-05

    A sensitive and specific HPLC method has been developed for the assay of vigabatrin in human plasma and urine. The assay involves derivatization with 4-chloro-7-nitrobenzofurazan, solid-phase extraction on a silica column and isocratic reversed-phase chromatography with fluorescence detection. Aspartam was used as an internal standard. The assay was linear over the concentration range of 0.2-20.0 microg/ml for plasma and 1.0-15.0 microg/ml for urine with a lower limit of detection of 0.1 microg/ml using 0.1 ml of starting volume of the sample. Both the within-day and day-to-day reproducibilities and accuracies were less than 5.46% and 1.6%, respectively. After a single oral dose of 500 mg of vigabatrin, the plasma concentration and the cumulative urinary excretion of the drug were determined.

  4. A direct HPLC method for the resolution and quantitation of the R-(-)- and S-(+)-enantiomers of vigabatrin (gamma-vinyl-GABA) in pharmaceutical dosage forms using teicoplanin aglycone chiral stationary phase.

    PubMed

    Al-Majed, Abdulrahman A

    2009-08-15

    A direct chiral high-performance liquid chromatography (HPLC) method was developed and validated for the resolution and quantification of antiepileptic drug enantiomers, R-(-)- and S-(+)-vigabatrin (gamma-vinyl-gamma-aminobutyric acid) in pharmaceutical products. The separation was optimized on a macrocyclic glycopeptide antibiotic chiral stationary phase (CSP) based on teicoplanin aglycone, chirobiotic (TAG), using a mobile phase system containing ethanol-water (80:20, v/v), at a flow rate of 0.4ml/min and UV detection set at 210nm. The stability of vigabatrin enantiomers under different degrees of temperature was also studied. The enantiomers of vigabatrin were separated from each other. The calibration curves were linear over a range of 100-1600microg/ml (r=0.999) for both enantiomers. The overall recoveries of R-(-)- and S-(+)-vigabatrin enantiomers from pharmaceutical products were in the range of 98.3-99.8% with %RSD ranged from 0.48 to 0.52%. The limit of quantification (LOQ) and limit of detection (LOD) for each enantiomer were 100 and 25microg/ml, respectively. No interferences were found from commonly co-formulated excipients.

  5. Determination of vigabatrin in human plasma and urine by high-performance liquid chromatography with UV-Vis detection.

    PubMed

    Cetin, Sevil Müge; Atmaca, Sedef

    2004-03-26

    A simple and reliable high-performance liquid chromatographic (HPLC) method with UV-Vis detection has been developed and validated for the determination of vigabatrin (VG) in human plasma and urine. The samples were pre-column derivatizated with 1,2-naphthoquinone-4-sulphonic acid sodium salt (NQS). A good chromatographic separation was achieved on a C18 column with a mobile phase consisting of acetonitrile and 10 mM orthophosphoric acid (pH 2.5) gradient elution. Tranexamic acid was used as an internal standard (I.S.). The method was linear over the concentration range of 0.8-30.0 microg/ml for both samples. The method is precise (relative standard deviation (R.S.D.) <9.13%) and accurate (relative mean error (RME) <-8.75%); analytical recoveries were 81.07% for plasma and 83.05% for urine. The assay was applied to pharmacokinetic study in a healthy volunteer after a single oral administration of 1 g of vigabatrin.

  6. Vigabatrin and lamotrigine in refractory epilepsy.

    PubMed Central

    Stolarek, I; Blacklaw, J; Forrest, G; Brodie, M J

    1994-01-01

    Epilepsy arises from an imbalance of inhibitory and excitatory influences in the brain. Vigabatrin (VIG) decreases the breakdown of the inhibitory neurotransmitter gamma-aminobutyric acid, whereas lamotrigine (LTG) reduces presynaptic excitatory amino acid release. 22 patients with refractory epilepsy, treated with an anticonvulsant regimen containing VIG, entered a balanced, double blind, placebo controlled, crossover trial of additional LTG. Treatment periods of 12 weeks (25 mg, 50 mg, 100 mg LTG twice daily for four weeks at each dose, and matched placebo) were followed by wash out intervals of four weeks. 14 of the 20 patients completing the study improved, resulting in a significant fall in seizure days and numbers. Analysis of seizure type confirmed a beneficial effect on partial and secondary generalised tonic-clonic seizures. At the highest LTG dose (200 mg daily) there was a median fall of 37% in seizure count with nine (45%) patients reporting > 50% reduction. Three of these patients were seizure free during this month of treatment. Side effects were minimal throughout the study. Concentrations of other antiepileptic drugs, including those of carbamazepine 10,11-epoxide, were not modified by LTG. This study suggests a substantial efficacy for a regimen containing VIG and LTG. Combinations of drugs with complementary modes of action may provide a rational pharmacological approach to the management of refractory epilepsy. PMID:8057114

  7. Sensitive high-performance liquid chromatographic method with fluorometric detection for the simultaneous determination of gabapentin and vigabatrin in serum and urine.

    PubMed

    Wad, N; Krämer, G

    1998-01-23

    Serum concentrations of the antiepileptic drug gabapentin (GBP) are usually determined by high-performance liquid chromatography (HPLC) using UV photometric detection after pre-column derivatization with 2,4,6-trinitrobenzenesulphonic acid. Vigabatrin levels in serum are determined by HPLC using fluorescence detection. Like vigabatrin (VGB), gabapentin has also a primary amine group that easily reacts with o-phthaldialdehyde reagent and produces a fluorescing substance. By the use of fluorometric detection, GBP can be determined more simply, sensitively and simultaneously with VGB. The day-to-day coefficient of variation for the determination of GBP in a pooled serum was 4.0% (n=17; serum concentration, 13.8 micromol/l) and forVGB was 3.1% (n=21; serum concentration, 26.4 micromol/l). The lower limit of detection is 0.5 micromol/l for both drugs and the method is linear up to 500 micromol/l for GBP and 1300 micromol/l for VGB.

  8. Simple high-performance liquid chromatographic method to monitor vigabatrin, and preliminary review of concentrations determined in epileptic patients.

    PubMed

    George, S; Gill, L; Braithwaite, R A

    2000-05-01

    A simple and rapid high-performance liquid chromatographic method has been developed for the determination of vigabatrin concentrations in plasma or serum. The assay uses only 100 microL of specimen and has been found to be linear over a concentration range of 1 to 50 mg/L. The limit of detection has been determined as 1 mg/L, and the between-batch coefficient of variation for the two internal quality controls routinely analysed (n = 33) has been found to be less than 5%. There was no evidence of interferences in the assay from other commonly prescribed anti-epileptic drugs. This method has been applied to routine clinical specimens to determine the concentration of vigabatrin in 47 patient specimens over a 12-month period. It was found that only 63% of the male group and 53% of the female group were within the proposed target concentration of 5 to 35 mg/L. In addition, it was found that 26% of the male group and 36% of the female group were found to have concentrations below 5 mg/L, which may indicate lack of compliance and/or lack of therapeutic efficacy of treatment.

  9. Vigabatrin therapy implicates neocortical high frequency oscillations in an animal model of infantile spasms.

    PubMed

    Frost, James D; Le, John T; Lee, Chong L; Ballester-Rosado, Carlos; Hrachovy, Richard A; Swann, John W

    2015-10-01

    Abnormal high frequency oscillations (HFOs) in EEG recordings are thought to be reflections of mechanisms responsible for focal seizure generation in the temporal lobe and neocortex. HFOs have also been recorded in patients and animal models of infantile spasms. If HFOs are important contributors to infantile spasms then anticonvulsant drugs that suppress these seizures should decrease the occurrence of HFOs. In experiments reported here, we used long-term video/EEG recordings with digital sampling rates capable of capturing HFOs. We tested the effectiveness of vigabatrin (VGB) in the TTX animal model of infantile spasms. VGB was found to be quite effective in suppressing spasms. In 3 of 5 animals, spasms ceased after a daily two week treatment. In the other 2 rats, spasm frequency dramatically decreased but gradually increased following treatment cessation. In all animals, hypsarrhythmia was abolished by the last treatment day. As VGB suppressed the frequency of spasms, there was a decrease in the intensity of the behavioral spasms and the duration of the ictal EEG event. Analysis showed that there was a burst of high frequency activity at ictal onset, followed by a later burst of HFOs. VGB was found to selectively suppress the late HFOs of ictal complexes. VGB also suppressed abnormal HFOs recorded during the interictal periods. Thus VGB was found to be effective in suppressing both the generation of spasms and hypsarrhythmia in the TTX model. Vigabatrin also appears to preferentially suppress the generation of abnormal HFOs, thus implicating neocortical HFOs in the infantile spasms disease state. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Vigabatrin Therapy Implicates Neocortical High Frequency Oscillations in an Animal Model of Infantile Spasms

    PubMed Central

    Frost, James D.; Le, John T.; Lee, Chong L.; Ballester-Rosado, Carlos; Hrachovy, Richard A.; Swann, John W.

    2015-01-01

    Abnormal high frequency oscillations (HFOs) in EEG recordings are thought to be reflections of mechanisms responsible for focal seizure generation in the temporal lobe and neocortex. HFOs have also been recorded in patients and animal models of infantile spasms. If HFOs are important contributors to infantile spasms then anticonvulsant drugs that suppress these seizures should decrease the occurrence of HFOs. In experiments reported here, we used long-term video/EEG recordings with digital sampling rates capable of capturing HFOs. We tested the effectiveness of vigabatrin (VGB) in the TTX animal model of infantile spasms. VGB was found to be quite effective in suppressing spasms. In 3 of 5 animals, spasms ceased after a daily two week treatment. In the other 2 rats, spasm frequency dramatically decreased but gradually increased following treatment cessation. In all animals, hypsarrhythmia was abolished by the last treatment day. As VGB suppressed the frequency of spasms, there was a decrease in the intensity of the behavioral spasms and the duration of the ictal EEG event. Analysis showed that there was a burst of high frequency activity at ictal onset, followed by a later burst of HFOs. VGB was found to selectively suppress the late HFOs of ictal complexes. VGB also suppressed abnormal HFOs recorded during the interictal periods. Thus VGB was found to be effective in suppressing both the generation of spasms and hypsarrhythmia in the TTX model. Vigabatrin also appears to preferentially suppress the generation of abnormal HFOs, thus implicating neocortical HFOs in the infantile spasms disease state. PMID:26026423

  11. Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting

    PubMed Central

    Shannon, Richard J; Timofeev, Ivan; Nortje, Jürgens; Hutchinson, Peter J; Carpenter, Keri L H

    2014-01-01

    Aims The aims were to determine blood–brain barrier penetration and brain extracellular pharmacokinetics for the anticonvulsant vigabatrin (VGB; γ-vinyl-γ-aminobutyric acid) in brain extracellular fluid and plasma from severe traumatic brain injury (TBI) patients, and to measure the response of γ-aminobutyric acid (GABA) concentration in brain extracellular fluid. Methods Severe TBI patients (n = 10) received VGB (0.5 g enterally, every 12 h). Each patient had a cerebral microdialysis catheter; two patients had a second catheter in a different region of the brain. Plasma samples were collected 0.5 h before and 2, 4 and 11.5 h after the first VGB dose. Cerebral microdialysis commenced before the first VGB dose and continued through at least three doses of VGB. Controls were seven severe TBI patients with microdialysis, without VGB. Results After the first VGB dose, the maximum concentration of VGB (Cmax) was 31.7 (26.9–42.6) μmol l−1 (median and interquartile range for eight patients) in plasma and 2.41 (2.03–5.94) μmol l−1 in brain microdialysates (nine patients, 11 catheters), without significant plasma–brain correlation. After three doses, median Cmax in microdialysates increased to 5.22 (4.24–7.14) μmol l−1 (eight patients, 10 catheters). Microdialysate VGB concentrations were higher close to focal lesions than in distant sites. Microdialysate GABA concentrations increased modestly in some of the patients after VGB administration. Conclusions Vigabatrin, given enterally to severe TBI patients, crosses the blood–brain barrier into the brain extracellular fluid, where it accumulates with multiple dosing. Pharmacokinetics suggest delayed uptake from the blood. PMID:24802902

  12. Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting.

    PubMed

    Shannon, Richard J; Timofeev, Ivan; Nortje, Jürgens; Hutchinson, Peter J; Carpenter, Keri L H

    2014-11-01

    The aims were to determine blood-brain barrier penetration and brain extracellular pharmacokinetics for the anticonvulsant vigabatrin (VGB; γ-vinyl-γ-aminobutyric acid) in brain extracellular fluid and plasma from severe traumatic brain injury (TBI) patients, and to measure the response of γ-aminobutyric acid (GABA) concentration in brain extracellular fluid. Severe TBI patients (n = 10) received VGB (0.5 g enterally, every 12 h). Each patient had a cerebral microdialysis catheter; two patients had a second catheter in a different region of the brain. Plasma samples were collected 0.5 h before and 2, 4 and 11.5 h after the first VGB dose. Cerebral microdialysis commenced before the first VGB dose and continued through at least three doses of VGB. Controls were seven severe TBI patients with microdialysis, without VGB. After the first VGB dose, the maximum concentration of VGB (Cmax ) was 31.7 (26.9-42.6) μmol l(-1) (median and interquartile range for eight patients) in plasma and 2.41 (2.03-5.94) μmol l(-1) in brain microdialysates (nine patients, 11 catheters), without significant plasma-brain correlation. After three doses, median Cmax in microdialysates increased to 5.22 (4.24-7.14) μmol l(-1) (eight patients, 10 catheters). Microdialysate VGB concentrations were higher close to focal lesions than in distant sites. Microdialysate GABA concentrations increased modestly in some of the patients after VGB administration. Vigabatrin, given enterally to severe TBI patients, crosses the blood-brain barrier into the brain extracellular fluid, where it accumulates with multiple dosing. Pharmacokinetics suggest delayed uptake from the blood. © 2014 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

  13. Simultaneous isocratic HPLC determination of vigabatrin and gabapentin in human plasma by dansyl derivatization.

    PubMed

    Krivanek, Peter; Koppatz, Karl; Turnheim, Klaus

    2003-06-01

    A rapid and low-cost assay for simultaneous vigabatrin (VGA) and gabapentin (GBP) determination is described that can be performed with simple HPLC instrumentation. The method involves derivatization of the primary amine group of VGA and GBP with dansyl chloride followed by isocratic separation (column: microBondapak C-18, 10 microm, 300 x 3.9 mm; mobile phase: 50 mmol/L NaH(2)PO(4) in 40% acetonitrile) at 50 degrees C and fluorometric detection (excitation and emission wavelength: 318 and 510 nm, respectively) of the fluorescent product, which is stable for at least 7 days. Correlation coefficients of the calibration curves are >0.999 with a lower limit of detection of 0.3 microg/mL. Between- and within-run coefficients of variation are below 4.5%, and assay time is 15 minutes. This method may be used for therapeutic drug monitoring in the case of GBP and to control patient compliance in the case of VGA.

  14. Vigabatrin can enhance electroretinographic responses in pigmented and albino rats.

    PubMed

    Akula, James D; Noonan, Emily R; Di Nardo, Alessia; Favazza, Tara L; Zhang, Nan; Sahin, Mustafa; Hansen, Ronald M; Fulton, Anne B

    2015-08-01

    To evaluate the effects of the antiepileptic medication vigabatrin (VGB) on the retina of pigmented rats. Scotopic and photopic electroretinograms were recorded from dark- and light-adapted Long-Evans (pigmented) and Sprague Dawley (albino) rats administered, daily, 52-55 injections of 250 mg·kg(-1)·day(-1) VGB or 25-26 injections of 500 mg·kg(-1)·day(-1) VGB, or a corresponding number of sham injections. Sensitivity and saturated amplitude of the rod photoresponse (S, Rm(P3)) and postreceptor response (1/σ, Vm) were derived, as were sensitivity and amplitude of the cone-mediated postreceptor response (1/σ(cone), Vm(cone)). The oscillatory potentials and responses to a series of flickering lights (6.25, 12.5, 25 and 50 Hz) were studied in the time and frequency domains. A subset of rats' eyes was harvested for Western blotting or histology. Of the parameters derived from dark-adapted ERG responses, in both pigmented and albino rats, VGB repeatedly and reliably enhanced electroretinographic parameters; no significant ERG deficits were noted. No significant alterations were observed in ER/oxidative stress or in the Akt cell death/survival pathway. There were migrations of photoreceptor nuclei toward the RPE and outgrowths of bipolar cell dendrites into the outer nuclear layer in VGB-treated rats; these were never observed in sham-treated animals. Although VGB is associated with retinal dysfunction in patients and VGB toxicity has been demonstrated by other laboratories in the albino rat, in our pigmented and albino rats, VGB did not induce deficits in, but rather enhanced, retinal function. Nonetheless, retinal neuronal dysplasia was observed.

  15. 77 FR 30289 - Federal Advisory Committee Act; Technological Advisory Council

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    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council... Communications Commission's (FCC) Technological Advisory Council will hold a meeting on Wednesday, June 27, 2012... INFORMATION: The FCC Technological Advisory Council proposed a new work agenda for the [[Page 30290

  16. Stereoselective determination of vigabatrin enantiomers in human plasma by high performance liquid chromatography using UV detection.

    PubMed

    Franco, Valentina; Mazzucchelli, Iolanda; Fattore, Cinzia; Marchiselli, Roberto; Gatti, Giuliana; Perucca, Emilio

    2007-07-01

    A rapid and simple high-performance liquid chromatographic method for the determination of the R-(-)- and S-(+)-enantiomers of the antiepileptic drug vigabatrin in human plasma is described. After adding the internal standard (1-aminomethyl-cycloheptyl-acetic acid), plasma samples (200 microL) are deproteinized with acetonitrile and the supernatant is derivatized with 2,4,6 trinitrobenzene sulfonic acid (TNBSA). Separation is achieved on a reversed-phase cellulose-based chiral column (Chiralcel-ODR, 250 mm x 4.6 mm i.d.) using 0.05 M potassium hexafluorophosphate (pH 4.5)/acetonitrile/ethanol (50:40:10 vol/vol/vol) as mobile phase at a flow-rate of 0.9 mL/min. Chromatographic selectivity is improved by concentrating the derivatives on High Performance Extraction Disk Cartridges prior to injection. Detection is at 340 nm. Calibration curves are linear (r(2)> or =0.999) over the range of 0.5-40 microg/mL for each enantiomer, with a limit of quantification of 0.5 microg/mL for both analytes. The assay is suitable for therapeutic drug monitoring and for single-dose pharmacokinetic studies in man.

  17. Simultaneous determination of gabapentin, pregabalin, vigabatrin, and topiramate in plasma by HPLC with fluorescence detection.

    PubMed

    Martinc, Boštjan; Roškar, Robert; Grabnar, Iztok; Vovk, Tomaž

    2014-07-01

    Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) has been recognized as a useful tool in management of epilepsy. We developed a simple analytical method for simultaneous determination of four second generation AEDs, including gabapentin (GBP), pregabalin (PGB), vigabatrin (VGB), and topiramate (TOP). Analytes were extracted from human plasma using universal solid phase extraction, derivatized with 4-chloro-7-nitrobenzofurazan (NBD-Cl) and analyzed by HPLC with fluorescence detection. Using mass spectrometry we confirmed that NBD-Cl reacts with sulfamate group of TOP similarly as with amine group of the other three analytes. The method is linear (r(2)>0.998) across investigated analytical ranges (0.375-30.0μg/mL for GBP, PGB, and VGB; 0.50-20.0μg/mL for TOP). Intraday and interday precision do not exceed 9.40%. The accuracy is from 95.6% to 106%. The recovery is higher than 80.6%, and the lower limit of quantification is at least 0.5μg/mL. The method is selective and robust. For TOP determination the method was compared to a previously published method and the results obtained by the two methods were in good agreement. The developed method is suitable for routine TDM. Copyright © 2014 Elsevier B.V. All rights reserved.

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  20. FT-Raman, FT-IR and UV-visible spectral investigations and ab initio computations of anti-epileptic drug: Vigabatrin

    NASA Astrophysics Data System (ADS)

    Edwin, Bismi; Joe, I. Hubert

    2013-10-01

    Vibrational analysis of anti-epileptic drug vigabatrin, a structural GABA analog was carried out using NIR FT-Raman and FTIR spectroscopic techniques. The equilibrium geometry, various bonding features and harmonic vibrational wavenumbers were studied using density functional theory method. The detailed interpretation of the vibrational spectra has been carried out with the aid of VEDA.4 program. Vibrational spectra, natural bond orbital analysis and optimized molecular structure show clear evidence for the effect of electron charge transfer on the activity of the molecule. Predicted electronic absorption spectrum from TD-DFT calculation has been compared with the UV-vis spectrum. The Mulliken population analysis on atomic charges and the HOMO-LUMO energy were also calculated. Good consistency is found between the calculated results and experimental data for the electronic absorption as well as IR and Raman spectra. The blue-shifting of the Csbnd C stretching wavenumber reveals that the vinyl group is actively involved in the conjugation path. The NBO analysis confirms the occurrence of intramolecular hyperconjugative interactions resulting in ICT causing stabilization of the system.

  1. 78 FR 51191 - Government-wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting

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  4. Double-blind, placebo-controlled study of vigabatrin (gamma-vinyl GABA) in drug-resistant epilepsy.

    PubMed

    Loiseau, P; Hardenberg, J P; Pestre, M; Guyot, M; Schechter, P J; Tell, G P

    1986-01-01

    Vigabatrin (GVG) (3 g/day) and placebo were compared as an add-on to standard therapy in therapy-resistant epileptic patients using a double-blind crossover design with randomized treatment allocation. Twenty-three patients entered the trial, with four dropping out due to either increased seizure frequency following the cross-over from GVG to placebo (n = 1), intolerance to GVG therapy (n = 2), or poor seizure record (n = 1). Of the 19 patients who completed the study, 17 had partial seizures, eight of whom had secondary generalization and two who had primary generalized seizures. Compared with placebo, GVG was associated with a significant reduction in seizure frequency (p less than 0.01), with 11 of 19 patients experiencing greater than 50% reduction in weekly seizure occurrence, two showing a 25-50% reduction, four unchanged, and two showing an increase in seizures. Global efficacy ratings were greater in the GVG period for 15 patients (p less than 0.05) compared with one in whom there was no period difference and two in whom ratings were higher in the placebo period. Fourteen of the 19 patients indicated a preference for the GVG period. Adverse effects observed during GVG treatment were generally mild and consisted of drowsiness, confusion, nausea, irritability, and constipation. No clinically significant alterations in laboratory test results were observed. No treatment-related changes in plasma concentrations of concomitant antiepileptic drugs were noted. These results confirm the antiepileptic efficacy of oral GVG in refractory epileptics.

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  6. FT-Raman, FT-IR and UV-visible spectral investigations and ab initio computations of anti-epileptic drug: vigabatrin.

    PubMed

    Edwin, Bismi; Joe, I Hubert

    2013-10-01

    Vibrational analysis of anti-epileptic drug vigabatrin, a structural GABA analog was carried out using NIR FT-Raman and FTIR spectroscopic techniques. The equilibrium geometry, various bonding features and harmonic vibrational wavenumbers were studied using density functional theory method. The detailed interpretation of the vibrational spectra has been carried out with the aid of VEDA.4 program. Vibrational spectra, natural bond orbital analysis and optimized molecular structure show clear evidence for the effect of electron charge transfer on the activity of the molecule. Predicted electronic absorption spectrum from TD-DFT calculation has been compared with the UV-vis spectrum. The Mulliken population analysis on atomic charges and the HOMO-LUMO energy were also calculated. Good consistency is found between the calculated results and experimental data for the electronic absorption as well as IR and Raman spectra. The blue-shifting of the C-C stretching wavenumber reveals that the vinyl group is actively involved in the conjugation path. The NBO analysis confirms the occurrence of intramolecular hyperconjugative interactions resulting in ICT causing stabilization of the system. Copyright © 2013 Elsevier B.V. All rights reserved.

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... Defense announces the following Federal advisory committee meeting of the Threat Reduction Advisory..., CO. FOR FURTHER INFORMATION CONTACT: Mr. William Hostyn, DoD, Defense Threat Reduction Agency/J2/5/8R...

  17. 77 FR 2710 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... following Federal advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred... CONTACT: Mr. William Hostyn, GS-15, DoD, Defense Threat Reduction Agency/SP-ACP, 8725 John J. Kingman Road...

  18. Serum concentrations and effects of gabapentin and vigabatrin: observations from a dose titration study.

    PubMed

    Lindberger, Martin; Luhr, Owe; Johannessen, Svein I; Larsson, Sirkku; Tomson, Torbjörn

    2003-08-01

    To explore possible concentration-effect relationships, gabapentin (GBP) and vigabatrin (VGB) serum concentrations were obtained from patients participating in an add-on dose-titration trial comparing GBP and VGB in partial epilepsy. Patients randomized to GBP started on 1800 mg/d and could have their dosage increased stepwise to 2400 and 3600 mg/d if seizures persisted. Those randomised to VGB started on 1000 mg/d, and the dose could be increased to 2000 and 4000 mg/d. Blood samples were obtained at steady state, at a nonstandardized time, from 27 patients randomized to GBP and from 36 randomized to VGB. Serum samples were analyzed using high-performance liquid chromatography. The treatment effect was expressed as percentage reduction in number of seizures from baseline. In addition, patients were classified as responders (>50% reduction in number of seizures from baseline) or nonresponders. There was no significant correlation between serum concentrations of GBP and seizure reduction at the lowest dosage, 1800 mg/d (r = -0.02, P = 0.94, Spearman-rank), nor between VGB serum levels and seizure reduction at 1000 mg/d of VGB (r = -0.14, P = 0.44). The serum GBP concentrations among responders to GBP 1800 mg/d were 26 +/- 12 micro mol/L (mean +/- SD), which was not different from serum concentrations in nonresponders, 28+/-13 micro mol/L. Nor was there a difference between serum concentrations of responders and nonresponders to VGB 1000 mg/d (32 +/- 23 and 44 +/- 36 micro mol/L, respectively). Hence, with the present study design we were unable to identify specific target ranges of GBP and VGB serum concentrations.

  19. 75 FR 37410 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing AGENCY: Under Secretary of Defense for Personnel and Readiness, DoD...), and 41 CFR 102-3.150, DoD announces that the Defense Advisory Committee on Military Personnel Testing...

  20. 75 FR 63823 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory...), and 41 CFR 102-3.150, the Department of Defense announces that the Defense Advisory Committee on... OSD Federal Register Liaison Officer, Department of Defense. [FR Doc. 2010-26189 Filed 10-15-10; 8:45...

  1. 77 FR 19006 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred to as ``the.... William Hostyn, GS-15, DoD, Defense Threat Reduction Agency/SP-ACP, 8725 John J. Kingman Road, MS 6201...

  2. 77 FR 50088 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... following Federal advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred... INFORMATION CONTACT: Mr. William Hostyn, GS-15, DoD, Defense Threat Reduction Agency/J2/5/8R, 8725 John J...

  3. 77 FR 69807 - Threat Reduction Advisory Committee; Notice of Federal Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... DEPARTMENT OF DEFENSE Office of the Secretary Threat Reduction Advisory Committee; Notice of... following Federal advisory committee meeting of the Threat Reduction Advisory Committee (hereafter referred... INFORMATION CONTACT: Mr. William Hostyn, DoD, Defense Threat Reduction Agency/J2/5/8R-ACP, 8725 John J...

  4. 76 FR 52016 - NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-074)] NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel; Meeting AGENCY: National Aeronautics and Space... meeting of the NASA International Space Station Advisory Committee and the Aerospace Safety Advisory Panel...

  5. Effects of Vigabatrin, an Irreversible GABA Transaminase Inhibitor, on Ethanol Reinforcement and Ethanol Discriminative Stimuli in Mice

    PubMed Central

    Griffin, William C.; Nguyen, Shaun A.; Deleon, Christopher P.; Middaugh, Lawrence D.

    2012-01-01

    We tested the hypothesis that the irreversible gamma-amino butyric acid (GABA) transaminase inhibitor, γ-vinyl GABA (Vigabatrin; VGB) would reduce ethanol reinforcement and enhance the discriminative stimulus effect of ethanol, effectively reducing ethanol intake. The present studies used adult C57BL/6J (B6) mice in well-established operant, two-bottle choice consumption, locomotor activity and ethanol discrimination procedures, to examine comprehensively the effects of VGB on ethanol-supported behaviors. VGB dose-dependently reduced operant responding for ethanol as well as ethanol consumption for long periods of time. Importantly, a low dose (200 mg/kg) of VGB was selective for reducing ethanol responding without altering intake of food or water reinforcement. Higher VGB doses (>200 mg/kg) still reduced ethanol intake, but also significantly increased water consumption and, more modestly, increased food consumption. While not affecting locomotor activity on its own, VGB interacted with ethanol to reduce the stimulatory effects of ethanol on locomotion. Finally, VGB (200 mg/kg) significantly enhanced the discriminative stimulus effects of ethanol as evidenced by significant left-ward and up-ward shifts in ethanol generalization curves. Interestingly, VGB treatment was associated with slight increases in blood ethanol concentrations. The reduction in ethanol intake by VGB appears to be related to the ability of VGB to potentiate the pharmacological effects of ethanol. PMID:22336593

  6. 77 FR 55863 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (12-072)] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics... the Applied Science Advisory Group. This Subcommittee reports to the Earth Science Subcommittee...

  7. 77 FR 61581 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    .... Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory... advisory committee: U.S. Strategic Command Strategic Advisory Group. DATES: November 15, 2012, from 8 a.m... Command, during the development of the Nation's strategic war plans. Agenda: Topics include: Policy Issues...

  8. 78 FR 67131 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    .... Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory... following Federal Advisory Committee meeting of the U.S. Strategic Command Strategic Advisory Group. DATES... issues to the Commander, U.S. Strategic Command, during the development of the Nation's strategic war...

  9. 77 FR 46802 - National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ...-0100] National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory... Transportation (DOT). ACTION: Meeting Notice--National Emergency Medical Services Advisory Council. SUMMARY: The... NEMSAC is to provide a nationally recognized council of emergency medical services representatives and...

  10. 78 FR 49332 - National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ...-0091] National Emergency Medical Services Advisory Council (NEMSAC); Notice of Federal Advisory... Transportation (DOT). ACTION: Meeting Notice--National Emergency Medical Services Advisory Council. SUMMARY: The... emergency medical services representatives and consumers, is to advise and consult with DOT and the Federal...

  11. 75 FR 60484 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: (10-115)] NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics...) announces a meeting of the Applied Science Advisory Group. This Subcommittee reports to the Earth Science...

  12. 76 FR 60811 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group; Correction AGENCY: Department of Defense. ACTION: Notice of Advisory Committee... Command Strategic Advisory Group gave notice of a meeting to be held on November 1, 2011, from 8 a.m. to 5...

  13. 75 FR 60430 - Federal Advisory Committee; Threat Reduction Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Threat Reduction... amended) the Department of Defense announces a meeting of the Threat Reduction Advisory Committee... Wright, Defense Threat Reduction Agency/AST, 8725 John J. Kingman Road, MS 6201, Fort Belvoir, VA 22060...

  14. 78 FR 77443 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... announces a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... at: http://energy.gov/oe/services/electricity-advisory-committee-eac . FOR FURTHER INFORMATION...

  15. 75 FR 32469 - Consumer Advisory Council; Notice of Meeting of the Consumer Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... FEDERAL RESERVE SYSTEM Consumer Advisory Council; Notice of Meeting of the Consumer Advisory Council The Consumer Advisory Council will meet on Thursday, June 17, 2010. The meeting, which will be...'s responsibilities under various consumer financial services laws and on other matters on which the...

  16. 16 CFR 1018.26 - Advisory functions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Advisory functions. 1018.26 Section 1018.26 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 1018.26 Advisory functions. (a) Unless otherwise specifically provided by statute...

  17. 76 FR 29752 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ...The President's Management Advisory Board, a Federal Advisory Committee established in accordance with the Federal Advisory Committee Act (FACA), 5 U.S.C., App., and Executive Order 13538, will hold a public meeting on June 17, 2011.

  18. 75 FR 27557 - Federal Advisory Committee Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... the charter for the Advisory Committee for the 2012 Radiocommunication Conference (WRC-12 Advisory Committee), for a two-year period. The WRC-12 Advisory Committee is a Federal advisory committee under the... CONTACT: Alexander Roytblat, Designated Federal Official, WRC-12 Advisory Committee, FCC International...

  19. 77 FR 69869 - National Advisory Council on Alcohol Abuse and Alcoholism, National Advisory Council on Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Advisory Council on Alcohol Abuse and Alcoholism, National Advisory Council on Drug Abuse, and National Cancer Advisory Board; Notice of Joint Meeting Pursuant to section 10(a) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given o...

  20. 75 FR 43493 - Office of the Secretary; Federal Advisory Committee; Defense Intelligence Agency Advisory Board...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... DEPARTMENT OF DEFENSE Office of the Secretary; Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DOD. ACTION: Meeting notice... Department of Defense announces that Defense Intelligence Agency Advisory Board will meet on September 1 and...

  1. 75 FR 18824 - Federal Advisory Committee; Meeting of the Department of Defense Historical Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Meeting of the Department of Defense Historical Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Notice of... notice announces a meeting of the Department of Defense Historical Advisory Committee. During the meeting...

  2. 78 FR 21349 - Defense Advisory Committee on Military Personnel Testing; Notice of Federal Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Advisory Committee on Military Personnel... advisory committee meeting of the Defense Advisory Committee on Military Personnel Testing will take place... meeting is to review planned changes and progress in developing computerized tests for military enlistment...

  3. Citizens Advisory Committees.

    ERIC Educational Resources Information Center

    Stemnock, Suzanne K.

    1968-01-01

    This document contains the results of a national survey designed to determine the composition and location of permanent citizens advisory committees operating within the nation's school districts. The 52 district-wide, continuing citizens advisory bodies identified by 290 responding school systems are listed alphabetically by State. The following…

  4. Advisory: Definitions, Descriptions, Decisions, Directions.

    ERIC Educational Resources Information Center

    Galassi, John P.; Gulledge, Suzanne A.; Cox, Nancy D.

    Advisory groups have played an essential role in improving the school climate and conditions for young adolescents in schools. How middle school decision makers go about the process of designing or re-designing an advisory program needs to be considered. A discussion is presented of the background information that helps define advisories. It…

  5. 75 FR 2880 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2009-0160] Homeland Security Advisory Council... advisory committee meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet on February 3.... Mail: Homeland Security Advisory Council, 1100 Hampton Park Boulevard, Mailstop 0850, Capitol Heights...

  6. 77 FR 64335 - Notification of a Public Teleconference of the Science Advisory Board; Perchlorate Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... Science Advisory Board; Perchlorate Advisory Panel AGENCY: Environmental Protection Agency (EPA). ACTION... announces two public teleconferences of the SAB Perchlorate Advisory Panel to discuss its revised draft... Epidemiological Evidence to Develop a Maximum Contaminant Level Goal (MCLG) for Perchlorate. DATES: The public...

  7. 77 FR 25706 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ..., Command and Control, Science and Technology, Missile Defense. Meeting Accessibility: Pursuant to 5 U.S.C... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group AGENCY: Department of Defense. ACTION: Notice of Advisory Committee closed meeting...

  8. 16 CFR 1018.12 - Statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Statutory advisory committees. 1018.12 Section 1018.12 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.12 Statutory advisory committees. The Commission has...

  9. Public Library Advisory Board Handbook.

    ERIC Educational Resources Information Center

    Bailey, Alvin R., Ed.; And Others

    In Texas, public library advisory boards are a recent innovation that have developed as a result of the Council-Manager form of government. This handbook is a response to that development as a compilation of information on the most efficient roles and functions of advisory boards. An advisory board is appointed by the governing body of which the…

  10. 75 FR 33616 - Science Advisory Board Staff Office; Notification of Closed Meetings of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-14

    ... Closed Meetings of the Science Advisory Board's Scientific and Technological Achievement Awards Committee... Agency's (EPA), Science Advisory Board (SAB) Staff Office announces a meeting and teleconference of the....gov . The SAB Mailing address is: U.S. EPA Science Advisory Board (1400F), U.S. Environmental...

  11. 75 FR 4069 - Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9106-8] Science Advisory Board Staff Office; Notification of.... SUMMARY: The Environmental Protection Agency (EPA or Agency) Science Advisory Board (SAB) Staff Office is... may contact Ms. Kyndall Barry, Designated Federal Officer (DFO), EPA Science Advisory Board (1400F), U...

  12. 75 FR 10479 - Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9124-1] Science Advisory Board Staff Office; Notification of... Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff Office announces a public meeting of... may contact Ms. Kyndall Barry, Designated Federal Officer (DFO), EPA Science Advisory Board (1400F), U...

  13. 78 FR 50040 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission. ACTION: Notice of Meeting of Technology Advisory Committee. SUMMARY: The Commodity Futures Trading Commission (CFTC) announces that on September 12, 2013, the CFTC's Technology Advisory...

  14. 76 FR 44912 - Science Advisory Board Staff Office; Notification of Closed Meetings of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... Closed Meetings of the Science Advisory Board's Scientific and Technological Achievement Awards Committee... Agency's (EPA), Science Advisory Board (SAB) Staff Office announces a meeting and teleconference of the[email protected] . The SAB Mailing address is: U.S. EPA Science Advisory Board (1400R), U.S. Environmental...

  15. 78 FR 28207 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L..., Arlington, Virginia 22203. FOR FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity...

  16. 77 FR 15737 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The CFTC announces that on March 29, 2012, the CFTC's Technology Advisory Committee (``TAC'') will hold a...

  17. 77 FR 29995 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity Delivery and Energy Reliability, U.S. Department...

  18. 77 FR 58534 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity Delivery and Energy Reliability, U.S...

  19. 76 FR 59667 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L..., Virginia 22203. FOR FURTHER INFORMATION CONTACT: David Meyer, Office of Electricity Delivery and Energy...

  20. 75 FR 61454 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy, Office of Electricity Delivery and Energy Reliability. ACTION: Notice of open meeting. SUMMARY: This notice announces the open meeting of the re-established DOE Electricity Advisory Committee. The Federal Advisory...

  1. 76 FR 57023 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration (NOAA) Science Advisory... forth the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... date. SUPPLEMENTARY INFORMATION: The Science Advisory Board (SAB) was established by a Decision...

  2. 75 FR 54854 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... FURTHER INFORMATION CONTACT: Dr. Cynthia Decker, Executive Director, Science Advisory Board, NOAA, Rm...

  3. 76 FR 64088 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [Docket Number NIOSH-248] World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory...

  4. 50 CFR 100.12 - Local advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

  5. 50 CFR 100.12 - Local advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

  6. 76 FR 37103 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L...: David Meyer, Office of Electricity Delivery and Energy Reliability, U.S. Department of Energy, Forrestal...

  7. 77 FR 476 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration (NOAA) Science Advisory... forth the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... INFORMATION: The Science Advisory Board (SAB) was established by a Decision Memorandum dated September 25...

  8. 77 FR 14017 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463),...

  9. 77 FR 4820 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463),...

  10. 76 FR 81947 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463)...

  11. 75 FR 11883 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9126-2] Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory Board (SAB) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff...

  12. 75 FR 6358 - Federal Advisory Committee; Defense Advisory Board for Employer Support of the Guard and Reserve...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory Board...; Charter Revision AGENCY: Department of Defense (DoD). ACTION: Federal advisory committee charter. SUMMARY... Committee Reports to include the Under Secretary of Defense (Personnel and Readiness). FOR FURTHER...

  13. 77 FR 52335 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety.... Background: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  14. 77 FR 9254 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety.... Background: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  15. 77 FR 69486 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... people. Background: The Advisory Board was established under the Energy Employees Occupational Illness...

  16. 76 FR 5814 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety...: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  17. 75 FR 66769 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety...: The Advisory Board was established under the Energy Employees Occupational Illness Compensation...

  18. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  19. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  20. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  1. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  2. 13 CFR 130.360 - SBDC advisory boards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the operation of the SBDC network. (2) The advisory board shall be referred to as a State SBDC... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false SBDC advisory boards. 130.360... CENTERS § 130.360 SBDC advisory boards. (a) State/Regional Advisory Boards. (1) The Lead Center must...

  3. 78 FR 55692 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Office of Electricity Delivery and... a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... Electricity Delivery and Energy Reliability, U.S. Department of Energy, Forrestal Building, Room 8G-017, 1000...

  4. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Advisory guidelines. 724.403 Section 724.403 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  5. 77 FR 58356 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... Science Advisory Board (SAB) was established by a Decision Memorandum dated September 25, 1997, and is the...

  6. 76 FR 8715 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a rescheduled public meeting on March 1, 2011, from 1 p.m. to 5 p.m...

  7. 76 FR 75874 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of Meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on December 13, 2011, from 10 a.m. to 5 p.m., at the...

  8. 76 FR 776 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on January 27, 2011, from 1 p.m. to 5 p.m., at the...

  9. 77 FR 43090 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  10. 75 FR 35496 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  11. 77 FR 32117 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  12. 76 FR 47590 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Advisory Board was established under the Energy Employees Occupational Illness Compensation Program Act of...

  13. 75 FR 22560 - Federal Advisory Committee; Naval Research Advisory Committee; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Naval Research Advisory... 102-3.50, the Department of Defense gives notice that it is renewing the charter for the Naval... independent advice and recommendations to the Secretary of the Navy, the Chief of Naval Operations and the...

  14. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  15. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  16. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  17. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Advisory guidelines. 724.403 Section 724... (CONTINUED) IMPLEMENTATION OF TITLE II OF THE NOTIFICATION AND FEDERAL EMPLOYEE ANTIDISCRIMINATION AND RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to...

  18. 75 FR 2542 - Science Advisory Board Staff Office Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9104-2] Science Advisory Board Staff Office Notification of a Public Meeting of the Science Advisory Board Committee on Science Integration for Decisionmaking AGENCY... Agency) Science Advisory Board (SAB) Staff Office announces a public meeting of the SAB Committee on...

  19. 75 FR 9895 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9122-2] Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory Board; Committee on Science Integration for Decision Making... Agency (EPA or Agency) Science Advisory Board (SAB) Staff Office announces a public meeting of the SAB...

  20. 76 FR 53671 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency (DIA), Department of Defense... amended), and 41 CFR 102-3.150 the Department of Defense announces that Defense Intelligence Agency...

  1. 75 FR 57743 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory...

  2. 78 FR 68430 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  3. 78 FR 58294 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  4. 77 FR 59182 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory...

  5. 76 FR 77990 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory...

  6. 78 FR 17924 - U.S. Strategic Command Strategic Advisory Group; Notice of Federal Advisory Committee Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... DEPARTMENT OF DEFENSE Office of the Secretary U.S. Strategic Command Strategic Advisory Group... following federal advisory committee: U.S. Strategic Command Strategic Advisory Group. DATES: April 18, 2013..., intelligence, and policy-related issues to the Commander, U.S. Strategic Command, during the development of the...

  7. 76 FR 71567 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L...

  8. 78 FR 69682 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub...

  9. 76 FR 26301 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-06

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L...

  10. 78 FR 70932 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... of the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  11. 75 FR 57743 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act...: Purpose of the Committee: The purpose of the Unconventional Resources Technology Advisory Committee is to...

  12. 78 FR 53741 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... of the Unconventional Resources Technology Advisory Committee is to provide advice on development and...

  13. 75 FR 36346 - Olympic National Forest; Title II Resource Advisory Committee Meeting Advisory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... DEPARTMENT OF AGRICULTURE Olympic National Forest; Title II Resource Advisory Committee Meeting Advisory AGENCY: Olympic National Forest, USDA Forest Service. ACTION: Notice of meeting. SUMMARY: The... this meeting will be to review project proposals and provide recommendations for Title II projects to...

  14. 77 FR 2133 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of the Securities Industry and Financial... financing operations. Historically, this advice has been offered by debt management advisory committees...

  15. 78 FR 22034 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of The Securities Industry and Financial... financing operations. Historically, this advice has been offered by debt management advisory committees...

  16. 78 FR 62941 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of The Securities Industry and Financial... financing operations. Historically, this advice has been offered by debt management advisory committees...

  17. 77 FR 5246 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... Committee: The purpose of the Unconventional Resources Technology Advisory Committee is to provide advice on...

  18. 77 FR 63300 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act... Committee: The purpose of the Unconventional Resources Technology Advisory Committee is to provide advice on...

  19. 76 FR 64992 - Debt Management Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee; Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of the Securities Industry and Financial... operations. Historically, this advice has been offered by debt management advisory committees established by...

  20. 28 CFR 0.129 - Professional Responsibility Advisory Office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Professional Responsibility Advisory... OF JUSTICE 2-Professional Responsibility Advisory Office § 0.129 Professional Responsibility Advisory Office. (a) The Professional Responsibility Advisory Office is headed by a Director appointed by the...

  1. 77 FR 47593 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee... CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's...

  2. ITS Standards Advisory : Dynamic Message Signs (DMS)

    DOT National Transportation Integrated Search

    2003-01-01

    ITS Standards Advisories provide the transportation community with information and guidance on key activities related to ITS standards, with each Advisory focusing on a single ITS application and its corresponding standards. This advisory focuses on ...

  3. 16 CFR 16.13 - Renewal of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Renewal of advisory committees. 16.13 Section 16.13 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.13 Renewal of advisory committees. (a) Any advisory committee...

  4. 16 CFR 16.12 - Termination of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Termination of advisory committees. 16.12 Section 16.12 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.12 Termination of advisory committees. Any advisory committee shall...

  5. 16 CFR 1018.13 - Non-statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Non-statutory advisory committees. 1018.13 Section 1018.13 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.13 Non-statutory advisory committees. (a) In proposing...

  6. 49 CFR 95.7 - Industry advisory committees: Membership.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Industry advisory committees: Membership. 95.7 Section 95.7 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.7 Industry advisory committees: Membership. Each industry advisory committee must be reasonably representative of the...

  7. 49 CFR 95.7 - Industry advisory committees: Membership.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Industry advisory committees: Membership. 95.7 Section 95.7 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.7 Industry advisory committees: Membership. Each industry advisory committee must be reasonably representative of the...

  8. 49 CFR 95.7 - Industry advisory committees: Membership.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Industry advisory committees: Membership. 95.7 Section 95.7 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.7 Industry advisory committees: Membership. Each industry advisory committee must be reasonably representative of the...

  9. 75 FR 17701 - High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... DEPARTMENT OF ENERGY High Energy Physics Advisory Panel AGENCY: Department of Energy, Office of... Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires... Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000 Independence...

  10. 22 CFR 214.32 - Calling of advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Calling of advisory committee meetings. 214.32 Section 214.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 214.32 Calling of advisory committee meetings. (a) No advisory committee...

  11. 76 FR 41196 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee... INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor...

  12. 76 FR 12317 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee..., Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's Office, (307) 578-5164...

  13. 75 FR 38086 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee Meeting The Commodity Futures Trading Commission's (``Commission'') Technology Advisory Committee will conduct a meeting on Wednesday... Technology Advisory Committee, which will inform the Commission of technological issues and developments...

  14. 77 FR 18786 - Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... DEPARTMENT OF AGRICULTURE Forest Service Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting... Chief's 10-Year Stewardship Challenge, Upper Yakima Basin Water Enhancement Project, Holden Mine...

  15. 49 CFR 95.11 - Meetings; industry advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Meetings; industry advisory committees. 95.11... Meetings; industry advisory committees. (a) Meetings of an industry advisory committee may be held only at...) No industry advisory committee may receive, compile, or discuss data or reports showing the current...

  16. 49 CFR 95.11 - Meetings; industry advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Meetings; industry advisory committees. 95.11... Meetings; industry advisory committees. (a) Meetings of an industry advisory committee may be held only at...) No industry advisory committee may receive, compile, or discuss data or reports showing the current...

  17. 49 CFR 95.11 - Meetings; industry advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Meetings; industry advisory committees. 95.11... Meetings; industry advisory committees. (a) Meetings of an industry advisory committee may be held only at...) No industry advisory committee may receive, compile, or discuss data or reports showing the current...

  18. 77 FR 56607 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) is... call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone...

  19. 75 FR 9416 - Advisory Committee Information Hotline

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Drugs Advisory Committee 3014512542 Peripheral and Central Nervous System Drugs Advisory Committee... Devices Panel 3014512624 Circulatory System Devices Panel 3014512625 Clinical Chemistry and Clinical... about any particular advisory committee meeting, this system will provide interested parties with timely...

  20. 77 FR 43064 - Meeting; Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... COMMODITY FUTURES TRADING COMMISSION Meeting; Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (CFTC). ACTION: Notice of emergency meeting of technology advisory committee. SUMMARY: The CFTC announces that on Thursday, July 26, 2012, the CFTC's Technology Advisory Committee...

  1. 22 CFR 214.2 - Definition of advisory committee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Definition of advisory committee. 214.2 Section 214.2 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT General § 214.2 Definition of advisory committee. (a) The term advisory committee is defined in section 3(2) of...

  2. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  3. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  4. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  5. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  6. 10 CFR 7.4 - Establishment of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Establishment of advisory committees. 7.4 Section 7.4 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.4 Establishment of advisory committees. (a) An NRC advisory committee may be established under this part only if its establishment— (1) Is...

  7. 76 FR 3081 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee... meeting will be held via conference call. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory...

  8. 78 FR 64910 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... DEPARTMENT OF AGRICULTURE Forest Service Virginia Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Virginia Resource Advisory Committee will meet in... Resource Advisory Committee meetings are subject to change or cancellation. Contact Michael Williams...

  9. 75 FR 46902 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... DEPARTMENT OF AGRICULTURE Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in..., 3031 Tongass Avenue, Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory Committee...

  10. 77 FR 47592 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in... District, 3031 Tongass Avenue, Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory...

  11. 77 FR 51512 - Allegheny Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... DEPARTMENT OF AGRICULTURE Forest Service Allegheny Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Allegheny Resource Advisory Committee will meet in...: The following business will be conducted: Allegheny Resource Advisory Committee members will solicit...

  12. 76 FR 23537 - Resource Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... DEPARTMENT OF AGRICULTURE Resource Advisory Committee Meeting AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Sabine National Forest Resource Advisory Committee. SUMMARY: In accordance with.... Department of Agriculture, Forest Service, Sabine National Forest Resource Advisory Committee (RAC) meeting...

  13. 77 FR 18797 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence... meeting necessarily includes discussions of classified information relating to DIA's intelligence... capabilities in support of current intelligence operations. Agenda May 2, 2012 S 8:30 a.m Convene Advisory...

  14. 76 FR 70425 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence.... The meetings necessarily include discussions of classified information relating to DIA's intelligence... current intelligence operations. Agenda December 2, 2011 8:30 a.m Convene Advisory Mr. William Caniano...

  15. 77 FR 2277 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Intelligence.... The meetings necessarily include discussions of classified information relating to DIA's intelligence... intelligence operations. Agenda February 24, 2012 8:30 a.m Convene Advisory Mr. William Caniano, Board Meeting...

  16. Beach Advisory and Closing Online Notification (BEACON) system

    EPA Pesticide Factsheets

    Beach Advisory and Closing Online Notification system (BEACON) is a colletion of state and local data reported to EPA about beach closings and advisories. BEACON is the public-facing query of the Program tracking, Beach Advisories, Water quality standards, and Nutrients database (PRAWN) which tracks beach closing and advisory information.

  17. 77 FR 16894 - Financial Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... DEPARTMENT OF THE TREASURY Financial Research Advisory Committee AGENCY: Office of Financial Research, Treasury. ACTION: Notice of establishment of the Financial Research Advisory Committee and... is in the public interest to establish the Financial Research Advisory Committee. A Charter for the...

  18. 77 FR 10486 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery... announces a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L... 20229. FOR FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity Delivery and Energy...

  19. 78 FR 9038 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery... announces a meeting of the Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L..., Arlington, Virginia 22203. FOR FURTHER INFORMATION CONTACT: Matthew Rosenbaum, Office of Electricity...

  20. 76 FR 10577 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery... announces a meeting of the reestablished Electricity Advisory Committee (EAC). The Federal Advisory... CONTACT: David Meyer, Office of Electricity Delivery and Energy Reliability, U.S. Department of Energy...

  1. 75 FR 33241 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... 86341. Send written comments to Brady Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o...

  2. 75 FR 39656 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Brady Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o Forest Service, USDA, 1824 S...

  3. 77 FR 50675 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... DEPARTMENT OF AGRICULTURE Forest Service Virginia Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Virginia Resource Advisory Committee will meet in... Contact. All reasonable accommodation requests are managed on a case by case basis. Resource Advisory...

  4. 75 FR 52304 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Brady Smith. RAC Coordinator, Coconino Resource Advisory Committee, do Forest Service. USDA, 1824 5...

  5. 75 FR 6056 - National Geospatial Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary National Geospatial Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of renewal of National Geospatial Advisory Committee... renewed the National Geospatial Advisory Committee. The Committee will provide advice and recommendations...

  6. 75 FR 53707 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0074] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the... message. Fax: (202) 282-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security...

  7. 76 FR 55079 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0063] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...) 282-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445...

  8. 75 FR 26782 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0039] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the purpose of reviewing the final report of the HSAC's Quadrennial (Homeland Security) Review Advisory...

  9. 76 FR 58813 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0096] Homeland Security Advisory Council... meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445, 245...

  10. 77 FR 64532 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0064] Homeland Security Advisory Council... meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the...-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0445, 245...

  11. 76 FR 21877 - Environmental Management Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ... DEPARTMENT OF ENERGY Environmental Management Advisory Board AGENCY: Department of Energy. ACTION: Notice of call for nominations for appointment to the Environmental Management Advisory Board. SUMMARY... Environmental Management Advisory Board. DATES: Nominations will be accepted through May 13, 2011. ADDRESSES...

  12. 75 FR 7440 - Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Eastern Washington Cascades Provincial Advisory Committee and the Yakima Provincial Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting... Committee will meet on March 9, 2010 at the Sunnyslope Fire Station, 206 Easy Street, Wenatchee, WA. During...

  13. 75 FR 61693 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in Flagstaff, Arizona. The purpose of the meeting is to receive training on Resource Advisory Committees and...

  14. 76 FR 3081 - Sitka Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Sitka Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sitka Resource Advisory Committee will meet in Sitka...., Sitka, Alaska. Send written comments to Sitka Resource Advisory Committee, c/o District Ranger, USDA...

  15. 77 FR 54876 - Colville Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... DEPARTMENT OF AGRICULTURE Forest Service Colville Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Colville Resource Advisory Committee will meet in..., presentation and voting of 2012 Colville Resource Advisory Committee projects. The full agenda may be previewed...

  16. 76 FR 85 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in... Resource Advisory Committee, c/o Forest Service, USDA, 1824 S. Thompson St., Flagstaff, Arizona 86001 or...

  17. 75 FR 65295 - Sitka Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... DEPARTMENT OF AGRICULTURE Forest Service Sitka Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sitka Resource Advisory Committee will meet in Sitka..., 204 Siginaka Way, Sitka, Alaska. Send written comments to Sitka Resource Advisory Committee, c/o...

  18. 77 FR 26774 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2012-0021] Homeland Security Advisory Council.... SUMMARY: The Homeland Security Advisory Council (HSAC) will meet in person and members of the public may...-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security, Mailstop 0450, 245...

  19. 77 FR 67809 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). Federal Advisory Committee Act requires that public notice of these...

  20. 76 FR 54747 - State Energy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... DEPARTMENT OF ENERGY Energy Efficiency and Renewable Energy State Energy Advisory Board AGENCY: Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the State Energy Advisory Board (STEAB). The Federal Advisory...

  1. 76 FR 2672 - Science Advisory Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... forth the schedule and proposed agenda of a forthcoming meeting of the NOAA Science Advisory Board. The... CONTACT: Dr. Cynthia Decker, Executive Director, Science Advisory Board, NOAA, Rm. 11230, 1315 East-West...

  2. Rapid quantification of gabapentin, pregabalin, and vigabatrin in human serum by ultraperformance liquid chromatography with mass-spectrometric detection.

    PubMed

    Chahbouni, Abdel; Sinjewel, Arno; den Burger, Jeroen C G; Vos, René M; Wilhelm, Abraham J; Veldkamp, Agnes I; Swart, Eleanora L

    2013-02-01

    Gabapentin (GBP), pregabalin (PRG), and vigabatrin (VIG) are used for the prevention and treatment of epileptic seizures. The developed method was applied to samples from subjects participating in a pharmacokinetic study of GBP. Sample pretreatment consisted of adding 20 μL of trichloroacetic acid (30%; vol/vol) and 200 μL of GBP-d4 in acetonitrile as an internal standard to 20 μL of serum. Chromatographic separation was performed on an Acquity separation module using a Kinetex RP18 column. The aqueous and organic mobile phases were 2 mM ammonium acetate supplemented with 0.1% formic acid in water and acetonitrile, respectively. The detection by a tandem quadrupole mass spectrometer, operating in the positive mode using multiple reaction monitoring, was completed within 2 minutes. The method was linear over the range of 0.03-25 mg/L for GBP, 0.03-25 mg/L for PRG, and 0.06-50 mg/L for VIG. The between- and within-run accuracies ranged from 90% to 107%. The between- and within-run imprecisions of the method were <10%. Stability data show no significant decrease of the analytes. A relative matrix effect of -1%, 0.2%, and -5% was determined for GBP, PRG, and VIG, respectively. A simple and sensitive ultraperformance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification of GBP, PRG, and VIG in human serum. The reported method provided the necessary linearity, precision, and accuracy to allow the determination of GBP, PRG, and VIG for therapeutic drug monitoring and clinical research purposes.

  3. 29 CFR 1912.36 - Advice of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... members of an advisory committee shall not be a reason for not giving advice to the Assistant Secretary... 29 Labor 7 2010-07-01 2010-07-01 false Advice of advisory committees. 1912.36 Section 1912.36... Advice of advisory committees. (a) Approval by a majority of all members of an advisory committee is...

  4. 29 CFR 1912.36 - Advice of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... members of an advisory committee shall not be a reason for not giving advice to the Assistant Secretary... 29 Labor 7 2011-07-01 2011-07-01 false Advice of advisory committees. 1912.36 Section 1912.36... Advice of advisory committees. (a) Approval by a majority of all members of an advisory committee is...

  5. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  6. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  7. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  8. 16 CFR 1018.61 - Statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Statutory advisory committees. 1018.61 Section 1018.61 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Termination and Renewal § 1018.61 Statutory advisory committees. A new charter shall be filed for...

  9. 45 CFR 1222.4 - Advisory group responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Advisory group responsibilities. 1222.4 Section... COMMUNITY SERVICE PARTICIPATION OF PROJECT BENEFICIARIES § 1222.4 Advisory group responsibilities. The advisory group shall have the following responsibilities for the intent and purposes of these requirements...

  10. 78 FR 54680 - NASA Federal Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-109] NASA Federal Advisory Committees... by U.S. Citizens for Service on NASA Federal Advisory Committees. SUMMARY: NASA announces its annual invitation for public nominations for service on NASA Federal advisory committees. U.S. citizens may nominate...

  11. 75 FR 20371 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0030] Homeland Security Advisory Council... Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via teleconference for the... number in the subject line of the message. Fax: (202) 282-9207 Mail: Homeland Security Advisory Council...

  12. 75 FR 67351 - Environmental Management Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF ENERGY Environmental Management Advisory Board AGENCY: Department of Energy. ACTION... Management Advisory Board (EMAB). The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat. 770... Management (EM) with advice and recommendations on corporate issues confronting the EM program. EMAB will...

  13. 75 FR 7255 - Army Educational Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ... DEPARTMENT OF DEFENSE Department of the Army Army Educational Advisory Committee AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY: Pursuant to the Federal Advisory... Committee: U.S. Army War College Subcommittee of the Army Education Advisory Committee. Date of Meeting...

  14. 76 FR 72914 - Army Educational Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... DEPARTMENT OF DEFENSE Department of the Army Army Educational Advisory Committee AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY: Pursuant to the Federal Advisory...: U.S. Army War College Subcommittee of the Army Education Advisory Committee. Dates of Meeting...

  15. 76 FR 12087 - Army Educational Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... DEPARTMENT OF DEFENSE Department of the Army Army Educational Advisory Committee AGENCY: Department of the Army, DoD. ACTION: Notice of open meeting. SUMMARY: Pursuant to the Federal Advisory...: U.S. Army War College Subcommittee of the Army Education Advisory Committee. Dates of Meeting: March...

  16. 75 FR 67351 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  17. 78 FR 29125 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). Federal Advisory Committee Act (Pub. L. 94-463, 86 Stat. 770) requires...

  18. 76 FR 67717 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  19. 75 FR 13269 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  20. 77 FR 26274 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-03

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Department of Energy, Office of Nuclear Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Pub. Law 92-463, 86 Stat. 770...

  1. 75 FR 56997 - Global Markets Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... COMMODITY FUTURES TRADING COMMISSION Global Markets Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Global Markets Advisory Committee. SUMMARY: The Global Markets Advisory Committee will hold a public meeting on October 5, 2010, from 1 p.m. to 5...

  2. 75 FR 58367 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... COMMODITY FUTURES TRADING COMMISSION Technology Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold a public meeting on October 12, 2010, from 1 p.m. to 5 p.m...

  3. 22 CFR 8.9 - Meetings of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Meetings of advisory committees. 8.9 Section 8.9 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.9 Meetings of advisory committees. (a) Applicability. The term “meeting” covers any situation in which all or some of the members of an advisory committee convene with...

  4. 78 FR 11899 - Invasive Species Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY... notice of public meetings of the Invasive Species Advisory Committee. The document contained incorrect..., March 6, 2013; 9 a.m. to 1:45 p.m. Meeting of the Invasive Species Advisory Committee (OPEN): Thursday...

  5. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Local advisory committees... SUBSISTENCE MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 242.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory Committees within each region as...

  6. 36 CFR 242.12 - Local advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Local advisory committees... SUBSISTENCE MANAGEMENT REGULATIONS FOR PUBLIC LANDS IN ALASKA Program Structure § 242.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory Committees within each region as...

  7. 76 FR 2081 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan, Alaska, March 29, 2011. The purpose of this meeting is... written comments to Ketchikan Resource Advisory Committee, c/o District Ranger, USDA Forest Service, 3031...

  8. 76 FR 31935 - Juneau Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... DEPARTMENT OF AGRICULTURE Forest Service Juneau Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Juneau Resource Advisory Committee will meet in Juneau... Atadero, Juneau Resource Advisory Committee, PO Box 21628, Juneau, AK 99802, or by e-mail to [email protected

  9. 29 CFR 1430.8 - Advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Advisory committee meetings. 1430.8 Section 1430.8 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE FEDERAL MEDIATION AND CONCILIATION SERVICE ADVISORY COMMITTEES § 1430.8 Advisory committee meetings. (a) Initiation of meetings. (1...

  10. 78 FR 70932 - Nuclear Energy Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... DEPARTMENT OF ENERGY Nuclear Energy Advisory Committee AGENCY: Office of Nuclear Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Nuclear Energy Advisory Committee (NEAC). The Federal Advisory Committee Act (Public Law No. 94-463, 86 Stat. 770...

  11. 75 FR 22561 - Federal Advisory Committee; United States Strategic Command Strategic Advisory Group; Charter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Command Strategic Advisory Group; Charter Renewal AGENCY: Department of Defense (DoD). ACTION: Renewal of... Command Strategic Advisory Group (hereafter referred to as the Group). FOR FURTHER INFORMATION CONTACT... Chairman of the Joint Chiefs of Staff and the Commander of the U.S. Strategic Command independent advice...

  12. 78 FR 45496 - Flathead Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... DEPARTMENT OF AGRICULTURE Forest Service Flathead Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Flathead Resource Advisory Committee will meet in.... September 24, 2013--4:00 p.m. to 6:30 p.m. All Resource Advisory Committee meetings are subject to change or...

  13. 36 CFR 219.25 - Science advisory boards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Science advisory boards. 219... PLANNING National Forest System Land and Resource Management Planning The Contribution of Science § 219.25 Science advisory boards. (a) National science advisory board. The Forest Service Deputy Chief for Research...

  14. 36 CFR 219.25 - Science advisory boards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Science advisory boards. 219... PLANNING National Forest System Land and Resource Management Planning The Contribution of Science § 219.25 Science advisory boards. (a) National science advisory board. The Forest Service Deputy Chief for Research...

  15. 78 FR 20685 - Aviation Security Advisory Committee (ASAC) Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration Aviation Security Advisory...; Notice of Closed Federal Advisory Committee Meeting. SUMMARY: The Aviation Security Advisory Committee... Committee Act, 5 U.S.C. App. (Pub. L. 92-463). The Aviation Security Advisory Committee (ASAC) provides...

  16. 76 FR 64122 - NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-095)] NASA Advisory Committee; Renewal of NASA's International Space Station Advisory Committee Charter AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of renewal and amendment of the Charter of the International...

  17. National and Governmental Advisory Committees: Meetings

    EPA Pesticide Factsheets

    Meetings and Teleconference Information for the National Advisory Committee and Governmental Advisory Committee to the United States Representative to the North American Commission for Environmental Cooperation,

  18. 16 CFR 1018.14 - Non-Commission established advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Non-Commission established advisory committees. 1018.14 Section 1018.14 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Establishment of Advisory Committees § 1018.14 Non-Commission established advisory...

  19. 21 CFR 20.118 - Advisory committee records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Advisory committee records. 20.118 Section 20.118 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PUBLIC INFORMATION Availability of Specific Categories of Records § 20.118 Advisory committee records. All advisory...

  20. 36 CFR 219.18 - Role of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PLANNING National Forest System Land and Resource Management Planning Collaborative Planning for Sustainability § 219.18 Role of advisory committees. (a) Advisory committees. Advisory committees can provide an...)). Ecological, Social, and Economic Sustainability ...

  1. Linchpins or Lost Time: Creating Effective Advisories

    ERIC Educational Resources Information Center

    Johnson, Bil

    2009-01-01

    That advisories in secondary schools are fairly pervasive around the country may be one of the great unintended consequences of the Coalition of Essential Schools (CES) reform effort. While no CES Common Principle explicitly states that advisories should exist in schools, as Coalition Schools evolved, advisories became one of the logical ways for…

  2. 75 FR 18470 - Olympic National Forest; Federal Register-Title II Resource Advisory Committee Meeting Advisory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... DEPARTMENT OF AGRICULTURE Forest Service Olympic National Forest; Federal Register--Title II Resource Advisory Committee Meeting Advisory AGENCY: Olympic National Forest, USDA Forest Service. ACTION... recommendations for Title II projects to be funded by the Secure Rural Schools and Community Self- Determination...

  3. The California Earthquake Advisory Plan: A history

    USGS Publications Warehouse

    Roeloffs, Evelyn A.; Goltz, James D.

    2017-01-01

    Since 1985, the California Office of Emergency Services (Cal OES) has issued advisory statements to local jurisdictions and the public following seismic activity that scientists on the California Earthquake Prediction Evaluation Council view as indicating elevated probability of a larger earthquake in the same area during the next several days. These advisory statements are motivated by statistical studies showing that about 5% of moderate earthquakes in California are followed by larger events within a 10-km, five-day space-time window (Jones, 1985; Agnew and Jones, 1991; Reasenberg and Jones, 1994). Cal OES issued four earthquake advisories from 1985 to 1989. In October, 1990, the California Earthquake Advisory Plan formalized this practice, and six Cal OES Advisories have been issued since then. This article describes that protocol’s scientific basis and evolution.

  4. A Guide for Planning, Organizing, and Utilizing Advisory Councils.

    ERIC Educational Resources Information Center

    Illinois State Office of Education, Springfield. Div. of Vocational and Technical Education.

    Designed for administrators and teachers at the community college/secondary/elementary levels, the guide is a reference source for establishing and developing citizen advisory councils. A section on Advisory Councils--Planning discusses the need for citizen advisory councils, definition and purpose, advisory council types, and operational…

  5. 75 FR 48320 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  6. 77 FR 53191 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Department of... of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  7. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  8. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  9. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  10. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  11. 42 CFR 90.9 - Public health advisory.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Public health advisory. 90.9 Section 90.9 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH... PROCEDURES § 90.9 Public health advisory. ATSDR may issue a public health advisory based on the findings of a...

  12. Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

    PubMed Central

    2016-01-01

    γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA levels in the brain, which can terminate seizures as well as have potential therapeutic applications in treating other neurological disorders, including drug addiction. Among the analogues that we previously developed, (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115) showed 187 times greater potency than that of vigabatrin, a known inactivator of GABA-AT and approved drug (Sabril) for the treatment of infantile spasms and refractory adult epilepsy. Recently, CPP-115 was shown to have no adverse effects in a Phase I clinical trial. Here we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GABA-AT-catalyzed hydrolysis of the difluoromethylene group to a carboxylic acid with concomitant loss of two fluoride ions and coenzyme conversion to pyridoxamine 5′-phosphate (PMP). The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopentanone-2,4-dicarboxylate (22) and two other precursors of this compound (20 and 21). Time-dependent inactivation occurs by a conformational change induced by the formation of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid and PMP (20), which disrupts an electrostatic interaction between Glu270 and Arg445 to form an electrostatic interaction between Arg445 and the newly formed carboxylate produced by hydrolysis of the difluoromethylene group in CPP-115, resulting in a noncovalent, tightly bound complex. This represents a novel mechanism for inactivation of GABA-AT and a new approach for the design of mechanism-based inactivators in general. PMID:25616005

  13. Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1 S ,3 S )-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Hyunbeom; Doud, Emma H.; Wu, Rui

    gamma-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA levels in the brain, which can terminate seizures as well as have potential therapeutic applications in treating other neurological disorders, including drug addiction. Among the analogues that we previously developed, (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115) showed 187 times greater potency than that of vigabatrin, a known inactivator of GABA-AT and approved drug (Sabril) for the treatment of infantile spasms and refractory adult epilepsy. Recently,more » CPP-115 was shown to have no adverse effects in a Phase I clinical trial. Here we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GABA-AT-catalyzed hydrolysis of the difluoromethylene group to a carboxylic acid with concomitant loss of two fluoride ions and coenzyme conversion to pyridoxamine 5'-phosphate (PMP). The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopentanone-2,4-dicarboxylate (22) and two other precursors of this compound (20 and 21). Time-dependent inactivation occurs by a conformational change induced by the formation of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid and PMP (20), which disrupts an electrostatic interaction between Glu270 and Arg445 to form an electrostatic interaction between Arg445 and the newly formed carboxylate produced by hydrolysis of the difluoromethylene group in CPP-115, resulting in a noncovalent, tightly bound complex. This represents a novel mechanism for inactivation of GABA-AT and a new approach for the design of mechanism-based inactivators in general.« less

  14. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).

    PubMed

    Lee, Hyunbeom; Doud, Emma H; Wu, Rui; Sanishvili, Ruslan; Juncosa, Jose I; Liu, Dali; Kelleher, Neil L; Silverman, Richard B

    2015-02-25

    γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA levels in the brain, which can terminate seizures as well as have potential therapeutic applications in treating other neurological disorders, including drug addiction. Among the analogues that we previously developed, (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115) showed 187 times greater potency than that of vigabatrin, a known inactivator of GABA-AT and approved drug (Sabril) for the treatment of infantile spasms and refractory adult epilepsy. Recently, CPP-115 was shown to have no adverse effects in a Phase I clinical trial. Here we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GABA-AT-catalyzed hydrolysis of the difluoromethylene group to a carboxylic acid with concomitant loss of two fluoride ions and coenzyme conversion to pyridoxamine 5'-phosphate (PMP). The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopentanone-2,4-dicarboxylate (22) and two other precursors of this compound (20 and 21). Time-dependent inactivation occurs by a conformational change induced by the formation of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid and PMP (20), which disrupts an electrostatic interaction between Glu270 and Arg445 to form an electrostatic interaction between Arg445 and the newly formed carboxylate produced by hydrolysis of the difluoromethylene group in CPP-115, resulting in a noncovalent, tightly bound complex. This represents a novel mechanism for inactivation of GABA-AT and a new approach for the design of mechanism-based inactivators in general.

  15. Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1 S ,3 S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

    DOE PAGES

    Lee, Hyunbeom; Doud, Emma H.; Wu, Rui; ...

    2015-01-23

    γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA levels in the brain, which can terminate seizures as well as have potential therapeutic applications in treating other neurological disorders, including drug addiction. Among the analogues that we previously developed, (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115) showed 187 times greater potency than that of vigabatrin, a known inactivator of GABA-AT and approved drug (Sabril) for the treatment of infantile spasms and refractory adult epilepsy. Recently,more » CPP-115 was shown to have no adverse effects in a Phase I clinical trial. Here we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GABA-AT-catalyzed hydrolysis of the difluoromethylene group to a carboxylic acid with concomitant loss of two fluoride ions and coenzyme conversion to pyridoxamine 5'-phosphate (PMP). The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopentanone-2,4-dicarboxylate (22) and two other precursors of this compound (20 and 21). Time-dependent inactivation occurs by a conformational change induced by the formation of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid and PMP (20), which disrupts an electrostatic interaction between Glu270 and Arg445 to form an electrostatic interaction between Arg445 and the newly formed carboxylate produced by hydrolysis of the difluoromethylene group in CPP-115, resulting in a noncovalent, tightly bound complex. Ultimately, this represents a novel mechanism for inactivation of GABA-AT and a new approach for the design of mechanism-based inactivators in general.« less

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, Hyunbeom; Doud, Emma H.; Wu, Rui

    γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GABA-AT raises GABA levels in the brain, which can terminate seizures as well as have potential therapeutic applications in treating other neurological disorders, including drug addiction. Among the analogues that we previously developed, (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115) showed 187 times greater potency than that of vigabatrin, a known inactivator of GABA-AT and approved drug (Sabril) for the treatment of infantile spasms and refractory adult epilepsy. Recently,more » CPP-115 was shown to have no adverse effects in a Phase I clinical trial. Here we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GABA-AT-catalyzed hydrolysis of the difluoromethylene group to a carboxylic acid with concomitant loss of two fluoride ions and coenzyme conversion to pyridoxamine 5'-phosphate (PMP). The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopentanone-2,4-dicarboxylate (22) and two other precursors of this compound (20 and 21). Time-dependent inactivation occurs by a conformational change induced by the formation of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid and PMP (20), which disrupts an electrostatic interaction between Glu270 and Arg445 to form an electrostatic interaction between Arg445 and the newly formed carboxylate produced by hydrolysis of the difluoromethylene group in CPP-115, resulting in a noncovalent, tightly bound complex. Ultimately, this represents a novel mechanism for inactivation of GABA-AT and a new approach for the design of mechanism-based inactivators in general.« less

  17. 32 CFR 1698.2 - Requests for advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ADVISORY OPINIONS § 1698.2 Requests for advisory opinions. (a) Any male born after December 31, 1959 who... advisory opinion as to the liability of any male person born after December 31, 1959 who has attained 18...

  18. 32 CFR 1698.2 - Requests for advisory opinions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ADVISORY OPINIONS § 1698.2 Requests for advisory opinions. (a) Any male born after December 31, 1959 who... advisory opinion as to the liability of any male person born after December 31, 1959 who has attained 18...

  19. 78 FR 1265 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-001] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel..., Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space Administration...

  20. 76 FR 62455 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-088)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel... Burch, Aerospace Safety Advisory Panel Administrative Officer, National Aeronautics and Space...

  1. 77 FR 10485 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  2. 76 FR 64923 - Unconventional Resources Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... DEPARTMENT OF ENERGY Unconventional Resources Technology Advisory Committee AGENCY: Office of... meeting of the Unconventional Resources Technology Advisory Committee. The Federal Advisory Committee Act.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Unconventional Resources Technology...

  3. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  4. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  5. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  6. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  7. 10 CFR 7.17 - Reports required for advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Reports required for advisory committees. 7.17 Section 7.17 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.17 Reports required for advisory committees. (a) The Commission shall furnish a report on the activities of NRC advisory committees annually...

  8. Non-Alumni Advisory Board Volunteers

    ERIC Educational Resources Information Center

    Nagai, Judy; Nehls, Kimberly

    2014-01-01

    Advisory boards typically offer guidance, support, social, and financial capital to academic units within colleges and universities. They are generally comprised of prominent volunteers from the community and appropriate industries or businesses. The results of this exploratory study found that non-alumni advisory board volunteers developed…

  9. 75 FR 52732 - Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... DEPARTMENT OF DEFENSE Office of the Secretary Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Renewal of..., the Department of Defense gives notice that it is renewing the charter for the Missile Defense...

  10. Automated Pilot Advisory System

    NASA Technical Reports Server (NTRS)

    Parks, J. L., Jr.; Haidt, J. G.

    1981-01-01

    An Automated Pilot Advisory System (APAS) was developed and operationally tested to demonstrate the concept that low cost automated systems can provide air traffic and aviation weather advisory information at high density uncontrolled airports. The system was designed to enhance the see and be seen rule of flight, and pilots who used the system preferred it over the self announcement system presently used at uncontrolled airports.

  11. 75 FR 61219 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (10-116)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel... Dakon, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space Administration...

  12. 76 FR 19147 - Aerospace Safety Advisory Panel; Meeting.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-06

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice (11-030)] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announce a forthcoming meeting of the Aerospace Safety Advisory Panel.... Kathy Dakon, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  13. 78 FR 56941 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-114] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel.... Harmony Myers, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  14. 77 FR 58413 - Aerospace Safety Advisory Panel; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-074] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel.... Harmony Myers, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  15. 77 FR 38090 - Aerospace Safety Advisory Panel; Meeting.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 12-044] Aerospace Safety Advisory Panel... Aeronautics and Space Administration announces a forthcoming meeting of the Aerospace Safety Advisory Panel.... Harmony Myers, Aerospace Safety Advisory Panel Executive Director, National Aeronautics and Space...

  16. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  17. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  18. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  19. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  20. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  1. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  2. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  3. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  4. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  5. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  6. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  7. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  8. 10 CFR 7.6 - Amendment to advisory committee charters.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Amendment to advisory committee charters. 7.6 Section 7.6 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.6 Amendment to advisory committee charters. (a) Final authority for amending the charter of an NRC advisory committee established or utilized by...

  9. 10 CFR 7.19 - Advisory committee members with disabilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Advisory committee members with disabilities. 7.19 Section 7.19 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.19 Advisory committee members with disabilities. An NRC advisory committee member who is disabled may be provided services by a personal assistant...

  10. 10 CFR 7.13 - Minutes of advisory committee meetings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Minutes of advisory committee meetings. 7.13 Section 7.13 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.13 Minutes of advisory committee meetings. (a) Detailed minutes shall be kept of each NRC advisory committee meeting. The minutes shall include...

  11. 78 FR 3498 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... DEPARTMENT OF THE TREASURY Departmental Offices Debt Management Advisory Committee Meeting Notice.... of the following debt management advisory committee: Treasury Borrowing Advisory Committee of The... decisions on major financing operations. Historically, this advice has been offered by debt management...

  12. 75 FR 16438 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... Tourism Advisory Board (Board) will hold a meeting to discuss topics related to the travel and tourism...

  13. 75 FR 14135 - U.S. Travel And Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel And Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an open meeting. SUMMARY: The U.S. Travel and Tourism Advisory...

  14. 75 FR 39496 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an open meeting. SUMMARY: The U.S. Travel and Tourism Advisory...

  15. 77 FR 56242 - Dodd-Frank Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of Meeting of Securities and Exchange Commission Dodd- Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the Dodd-Frank Wall...

  16. 77 FR 11084 - Army Education Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... DEPARTMENT OF DEFENSE Department of the Army Army Education Advisory Committee Meeting AGENCY... the Army announces the following committee meeting: Name of Committee: Army Education Advisory... , (757) 501-5810, or to the following address: Army Education Advisory Committee, Designated Federal...

  17. 77 FR 50089 - Army Education Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... DEPARTMENT OF DEFENSE Department of the Army Army Education Advisory Committee Meeting AGENCY... the Army announces the following committee meeting: Name of Committee: Army Education Advisory... , (757) 501-5810, or to the following address: Army Education Advisory Committee, Designated Federal...

  18. 75 FR 9887 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... DEPARTMENT OF ENERGY Advanced Scientific Computing Advisory Committee AGENCY: Department of Energy... Advanced Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L. 92-463... INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building...

  19. 76 FR 9765 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... DEPARTMENT OF ENERGY Advanced Scientific Computing Advisory Committee AGENCY: Office of Science... Advanced Scientific Computing Advisory Committee (ASCAC). The Federal Advisory Committee Act (Pub. L. 92... INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research, SC-21/Germantown Building...

  20. 76 FR 41559 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... management advisory committee: Treasury Borrowing Advisory Committee of The Securities Industry and Financial... decisions on major financing operations. Historically, this advice has been offered by debt management...

  1. 78 FR 19277 - Navigation Safety Advisory Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Safety Advisory Council; Meeting AGENCY: United States Coast Guard, DHS. ACTION: Notice of Federal Advisory Committee meeting: correction. SUMMARY: The Navigation Safety Advisory Council (NAVSAC) will meet..., groundings; Inland and International Rules of the Road; navigation regulations and equipment; routing...

  2. 76 FR 20336 - Defense Audit Advisory Committee (DAAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC) AGENCY... following Federal advisory committee meeting of the Defense Audit Advisory Committee will be held. DATES... management to include financial reporting processes, systems of internal controls, audit processes, and...

  3. 75 FR 18824 - Federal Advisory Committee; U.S. Strategic Command Strategic Advisory Group; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; U.S. Strategic Command... 102-3.150, the Department of Defense announces that the U.S. Strategic Command Strategic Advisory... Commander, U.S. Strategic Command, during the development of the Nation's strategic war plans. Agenda Topics...

  4. 76 FR 40726 - Notification of Public Teleconferences of the Science Advisory Board Radiation Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9435-3] Notification of Public Teleconferences of the Science... Protection Agency (EPA), Science Advisory Board Staff Office. ACTION: Notice. SUMMARY: The EPA Science... information concerning the EPA Science Advisory Board can be found at the EPA SAB Web site at http// www.epa...

  5. A Sensitive Period of Mice Inhibitory System to Neonatal GABA Enhancement by Vigabatrin is Brain Region Dependent

    PubMed Central

    Levav-Rabkin, Tamar; Melamed, Osnat; Clarke, Gerard; Farber, Malca; Cryan, John F; Dinan, Timothy G; Grossman, Yoram; Golan, Hava M

    2010-01-01

    Neurodevelopmental disorders, such as schizophrenia and autism, have been associated with disturbances of the GABAergic system in the brain. We examined immediate and long-lasting influences of exposure to the GABA-potentiating drug vigabatrin (GVG) on the GABAergic system in the hippocampus and cerebral cortex, before and during the developmental switch in GABA function (postnatal days P1–7 and P4–14). GVG induced a transient elevation of GABA levels. A feedback response to GABA enhancement was evident by a short-term decrease in glutamate decarboxylase (GAD) 65 and 67 levels. However, the number of GAD65/67-immunoreactive (IR) cells was greater in 2-week-old GVG-treated mice. A long-term increase in GAD65 and GAD67 levels was dependent on brain region and treatment period. Vesicular GABA transporter was insensitive to GVG. The overall effect of GVG on the Cl− co-transporters NKCC1 and KCC2 was an enhancement of their synthesis, which was dependent on the treatment period and brain region studied. In addition, a short-term increase was followed by a long-term decrease in KCC2 oligomerization in the cell membrane of P4–14 hippocampi and cerebral cortices. Analysis of the Ca2+ binding proteins expressed in subpopulations of GABAergic cells, parvalbumin and calbindin, showed region-specific effects of GVG during P4–14 on parvalbumin-IR cell density. Moreover, calbindin levels were elevated in GVG mice compared to controls during this period. Cumulatively, these results suggest a particular susceptibility of the hippocampus to GVG when exposed during days P4–14. In conclusion, our studies have identified modifications of key components in the inhibitory system during a critical developmental period. These findings provide novel insights into the deleterious consequences observed in children following prenatal and neonatal exposure to GABA-potentiating drugs. PMID:20043003

  6. 75 FR 80039 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... agenda for an open meeting of the U.S. Travel and Tourism Advisory Board (Board). The agenda may change...

  7. 76 FR 53666 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... agenda for an open meeting of the U.S. Travel and Tourism Advisory Board (Board). The agenda may change...

  8. 76 FR 21703 - U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... DEPARTMENT OF COMMERCE International Trade Administration U.S. Travel and Tourism Advisory Board: Meeting of the U.S. Travel and Tourism Advisory Board AGENCY: International Trade Administration, U.S... agenda for an open meeting of the U.S. Travel and Tourism Advisory Board (Board). The agenda may change...

  9. 77 FR 29705 - Dodd-Frank Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of First Meeting of Securities and Exchange Commission Dodd-Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the Dodd-Frank Wall...

  10. 77 FR 70807 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  11. 77 FR 47873 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  12. 76 FR 40929 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  13. 75 FR 50780 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  14. 76 FR 40714 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy... Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770... Fusion Energy Sciences; U.S. Department of Energy; 1000 Independence Avenue, SW., Washington, DC 20585...

  15. 78 FR 65980 - State Energy Advisory Board (STEAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ... DEPARTMENT OF ENERGY State Energy Advisory Board (STEAB) AGENCY: Department of Energy, Office of Energy Efficiency and Renewable Energy. ACTION: Notice of open teleconference. SUMMARY: This notice announces a teleconference call of the State Energy Advisory Board (STEAB). The Federal Advisory Committee...

  16. 75 FR 6369 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office... Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...: Katie Perine; Office of Basic Energy Sciences; U.S. Department of Energy; Germantown Building...

  17. 77 FR 5246 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Office of Science... of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L... FURTHER INFORMATION CONTACT: Katie Perine; Office of Basic Energy Sciences; U.S. Department of Energy...

  18. 78 FR 15937 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act requires that public notice of...

  19. 78 FR 2259 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Office of Science... Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770... Energy Sciences; U.S. Department of Energy; 1000 Independence Avenue SW.; Washington, DC 20585-1290...

  20. 77 FR 485 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Office of Science... Energy Sciences Advisory Committee (FESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... Sciences; U.S. Department of Energy; 1000 Independence Avenue SW., Washington, DC 20585-1290; Telephone...

  1. 77 FR 34352 - Meeting of Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... COMMODITY FUTURES TRADING COMMISSION Meeting of Technology Advisory Committee AGENCY: Commodity... 20, 2012, the CFTC's Technology Advisory Committee (``TAC'') will hold a public meeting at the CFTC's... of the Secretary. Please use the title ``Technology Advisory Committee'' in any written statement you...

  2. OCLC and Its Advisory Committees.

    ERIC Educational Resources Information Center

    Baker, Shirley K.

    1998-01-01

    Describes the Online Computer Library Center (OCLC) advisory committees in terms of research, public, college and university, and special libraries. All four of the type-of-library advisory groups work to shape OCLC policies and programs, according to the particular needs of each group. OCLC's financial and programmatic success depends upon…

  3. 75 FR 53694 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital Age AGENCY: Federal Communications Commission. ACTION: Notice of... Communications in the Digital Age (``Diversity Committee'') will hold a meeting on Tuesday, September 21, 2010 at...

  4. 78 FR 11142 - The National Advisory Council on Innovation and Entrepreneurship Meeting of the National Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Innovation and Entrepreneurship Meeting of the National Advisory Council on Innovation and Entrepreneurship... National Advisory Council on Innovation and Entrepreneurship (NACIE) has cancelled its open meeting... INFORMATION CONTACT: Nish Acharya, Office of Innovation and Entrepreneurship, Room 70007R, 1401 Constitution...

  5. 76 FR 41195 - Medbow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF AGRICULTURE Forest Service Medbow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... Community Self-Determination Act (Pub. L. 110- 343) and in compliance with the Federal Advisory Committee...

  6. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  7. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  8. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  9. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  10. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  11. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  12. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  13. 16 CFR 1018.62 - Non-statutory advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Non-statutory advisory committees. 1018.62 Section 1018.62 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Termination and Renewal § 1018.62 Non-statutory advisory committees. (a) Each non-statutory...

  14. 16 CFR 1018.5 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Advisory Committee Management Officer. 1018.5 Section 1018.5 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT General Provisions § 1018.5 Advisory Committee Management Officer. The Chairman shall designate an...

  15. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Advisory Committee Management Officer. 16.4 Section 16.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.4 Advisory Committee Management Officer. (a) The Commission shall...

  16. 77 FR 39690 - State Energy Advisory Board (STEAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... DEPARTMENT OF ENERGY State Energy Advisory Board (STEAB) AGENCY: Energy Efficiency and Renewable... teleconference call of the State Energy Advisory Board (STEAB). The Federal Advisory Committee Act (Pub. L. 92... Energy, Office of Energy Efficiency and Renewable Energy, 1000 Independence Ave. SW., Washington, DC...

  17. 75 FR 2159 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Scientific Earthquake Studies Advisory Committee... Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next meeting at the U.S. Geological.... Meetings of the Scientific Earthquake Studies Advisory Committee are open to the public. DATES: January 26...

  18. 76 FR 61113 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Scientific Earthquake Studies Advisory Committee...-503, the Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next meeting at the.... Meetings of the Scientific Earthquake Studies Advisory Committee are open to the public. DATES: November 2...

  19. 77 FR 12323 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... DEPARTMENT OF THE INTERIOR U.S. Geological Survey Scientific Earthquake Studies Advisory Committee...-503, the Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next meeting at the.... Meetings of the Scientific Earthquake Studies Advisory Committee are open to the public. DATES: March 29...

  20. 78 FR 56696 - National Environmental Education Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9900-99-OA] National Environmental Education Advisory Council... Advisory Committee Act, EPA gives notice of a meeting of the National Environmental Education Advisory..., functions and policies of EPA under the National Environmental Education Act (the Act). The purpose of this...

  1. 29 CFR 1430.3 - Establishment of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Establishment of advisory committees. 1430.3 Section 1430.3 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE FEDERAL MEDIATION AND CONCILIATION SERVICE ADVISORY COMMITTEES § 1430.3 Establishment of advisory committees. (a...

  2. 76 FR 17965 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  3. 75 FR 82410 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  4. 77 FR 16062 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  5. 77 FR 28897 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... (BIE) is announcing that the Advisory Board for Exceptional Children (Advisory Board) will hold its... Individuals with Disabilities Education Act of 2004 (IDEA) for Indian children with disabilities. DATES: The...

  6. 75 FR 53334 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY: Bureau of Indian Affairs, Interior. ACTION: Notice of meeting; correction. SUMMARY: The Bureau of Indian... Advisory Board for Exceptional Children (Advisory Board) will hold its next meeting in Washington, DC. The...

  7. 76 FR 48147 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of renewal of the Basic Energy Sciences Advisory Committee. SUMMARY... that the Basic Energy Sciences Advisory Committee will be renewed for a two-year period beginning July...

  8. 78 FR 38696 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office... Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... INFORMATION CONTACT: Katie Perine; Office of Basic Energy Sciences; U.S. Department of Energy; Germantown...

  9. 78 FR 6088 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Office of Science... Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... INFORMATION CONTACT: Katie Perine, Office of Basic Energy Sciences, U.S. Department of Energy; SC-22...

  10. 75 FR 8685 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ... DEPARTMENT OF ENERGY Fusion Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Fusion Energy Sciences Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...

  11. 76 FR 41234 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  12. 77 FR 41395 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  13. 75 FR 41838 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat...

  14. 76 FR 8358 - Basic Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... DEPARTMENT OF ENERGY Basic Energy Sciences Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Basic Energy Sciences Advisory Committee (BESAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86 Stat. 770...

  15. Procedures for setting curve advisory speed.

    DOT National Transportation Integrated Search

    2009-08-01

    The procedures described in this handbook are intended to improve consistency in curve signing and driver compliance with the advisory speed. The handbook describes guidelines for determining when an advisory speed is needed, criteria for identifying...

  16. National Space Council Users' Advisory Group

    NASA Image and Video Library

    2018-06-19

    Users' Advisory Group member Faith Ozmen, CEO of the Sierra Nevada Corporation is seen durring the first meeting of the National Space Council Users' Advisory Group, Tuesday, June 19, 2018 at NASA Headquarters in Washington. The Users' Advisory Group will advise and inform the National Space Council on a broad range of aerospace topics, including the impacts of U.S. and international laws and regulations, national security space priorities, scientific and human space exploration priorities, and ways to bolster support. Photo Credit: (NASA/Joel Kowsky)

  17. 75 FR 20844 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital Age AGENCY: Federal Communications Commission. ACTION: Notice of... Communications in the Digital Age (``Diversity Committee'') will hold a meeting on Tuesday, June 15, 2010 at 2:00...

  18. 75 FR 25212 - Federal Advisory Committee; Advisory Panel on Department of Defense Capabilities for Support of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Advisory Panel on Department of Defense Capabilities for Support of Civil Authorities After Certain Incidents AGENCY: Office of the Assistant Secretary of Defense (Homeland Defense and Americas' Security Affairs), DoD. ACTION...

  19. 16 CFR 16.15 - Reports of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Reports of advisory committees. 16.15 Section 16.15 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ADVISORY COMMITTEE MANAGEMENT § 16.15 Reports of advisory committees. (a) The Commission shall furnish, on...

  20. 29 CFR 1430.5 - Termination of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Termination of advisory committees. 1430.5 Section 1430.5 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE FEDERAL MEDIATION AND CONCILIATION SERVICE ADVISORY COMMITTEES § 1430.5 Termination of advisory committees. (a) All...

  1. 78 FR 42105 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ....97C22214.001] Advisory Board for Exceptional Children AGENCY: Bureau of Indian Affairs, Interior. ACTION... for Exceptional Children (Advisory Board) will hold its next meeting in Albuquerque, New Mexico. The... (IDEA) for Indian children with disabilities. DATES: The Advisory Board will meet on Thursday, July 18...

  2. 75 FR 73166 - Art Advisory Panel-Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Art Advisory Panel--Closed Meeting AGENCY: Internal Revenue Service, Treasury. ACTION: Notice of Closed Meeting of Art Advisory Panel for Decorative Art. SUMMARY: A closed meeting of the Art Advisory Panel will be held in Washington, DC. DATES: The...

  3. 78 FR 25064 - State Energy Advisory Board (STEAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy State Energy Advisory Board (STEAB) AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of... Energy Advisory Board (STEAB). The Federal Advisory Committee Act (Pub. L. 92-463; 86 Stat.770) requires...

  4. 78 FR 53740 - State Energy Advisory Board; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... DEPARTMENT OF ENERGY State Energy Advisory Board; Meeting AGENCY: Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a live Board meeting of the State Energy Advisory Board (STEAB). The Federal Advisory Committee Act (Pub. L. 92- 463...

  5. 77 FR 19017 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Energy Employees Occupational Illness Compensation Program [[Page 19018

  6. 76 FR 67715 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Science Advisory Board... (NOAA), Department of Commerce (DOC). ACTION: Notice of open meeting. SUMMARY: The Science Advisory... on strategies for research, education, and application of science to operations and information...

  7. 75 FR 63450 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86... 20852. FOR FURTHER INFORMATION CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory...

  8. 75 FR 66388 - Scientific Earthquake Studies Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... Studies Advisory Committee AGENCY: U.S. Geological Survey. ACTION: Notice of Meeting. SUMMARY: Pursuant to Public Law 106-503, the Scientific Earthquake Studies Advisory Committee (SESAC) will hold its next... Studies Advisory Committee are open to the public, seating may be limited due to room capacity. DATES: The...

  9. 75 FR 23288 - Advisory Board for Exceptional Children

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Advisory Board for Exceptional Children AGENCY... Exceptional Children (Advisory Board) will hold its next meeting in Old Town, Maine. The purpose of the... Indian children with disabilities. DATES: The Advisory Board will meet on Monday, May 17, 2010, from 8:30...

  10. 77 FR 22390 - Debt Management Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... DEPARTMENT OF THE TREASURY Debt Management Advisory Committee Meeting Notice is hereby given... Pennsylvania Avenue NW., Washington, DC, on May 1, 2012 at 11:30 a.m. of the following debt management advisory... advice has been offered by debt management advisory committees established by the several major segments...

  11. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  12. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  13. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  14. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  15. 28 CFR 1.11 - Advisory nature of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Advisory nature of regulations. 1.11 Section 1.11 Judicial Administration DEPARTMENT OF JUSTICE EXECUTIVE CLEMENCY § 1.11 Advisory nature of regulations. The regulations contained in this part are advisory only and for the internal guidance of...

  16. 75 FR 4819 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-121] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  17. 75 FR 41863 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-1262] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  18. 75 FR 63830 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-1937] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  19. 75 FR 33305 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 10-1032] Consumer Advisory Committee AGENCY: Federal... its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding consumer issues within the jurisdiction of the Commission and to...

  20. 78 FR 46330 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Office of Science... High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy...

  1. 76 FR 19986 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... FURTHER INFORMATION CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S...

  2. 77 FR 64799 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy... Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires... Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25...

  3. 21 CFR 14.145 - Procedures of a color additive advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Procedures of a color additive advisory committee... SERVICES GENERAL PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Color Additive Advisory Committees § 14.145 Procedures of a color additive advisory committee. (a) A color additive advisory committee is...

  4. 21 CFR 14.142 - Functions of a color additive advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Functions of a color additive advisory committee... SERVICES GENERAL PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Color Additive Advisory Committees § 14.142 Functions of a color additive advisory committee. (a) A color additive advisory committee reviews...

  5. 77 FR 62541 - Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... SECURITIES AND EXCHANGE COMMISSION [Release Nos. 33-9365; 34-68019; File No. 265-28] Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of Telephonic Meeting of Securities and Exchange Commission Investor Advisory Committee. SUMMARY: The Securities and Exchange...

  6. 77 FR 5801 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... FEDERAL COMMUNICATIONS COMMISSION [DA 12-105] Consumer Advisory Committee AGENCY: Federal... agenda of its Consumer Advisory Committee (Committee). The purpose of the Committee is to make... the participation of all consumers in proceedings before the Commission. DATES: The next meeting of...

  7. 78 FR 15968 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID: FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management... Management Agency (FEMA) is requesting individuals who are interested in serving on the National Advisory...

  8. 77 FR 9953 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2007-0008] National Advisory Council AGENCY: Federal Emergency Management Agency, DHS. ACTION: Committee Management... Management Agency (FEMA) is requesting individuals who are interested in serving on the National Advisory...

  9. 78 FR 14299 - Notification of a Public Meeting of the Science Advisory Board Chemical Assessment Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... Authorization Act (ERDDAA) codified at 42 U.S.C. 4365, to provide independent scientific and technical peer..., 2012 (76 FR 223 pp. 71561-62; 77 FR 168 pp. 52330-31, respectively). Information about the formation of.... Federal advisory committees and panels, including scientific advisory committees, provide independent...

  10. 21 CFR 14.147 - Membership of a color additive advisory committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Membership of a color additive advisory committee... SERVICES GENERAL PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Color Additive Advisory Committees § 14.147 Membership of a color additive advisory committee. (a) The members of a color additive advisory...

  11. 22 CFR 214.31 - A.I.D. Advisory Committee Representative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... MANAGEMENT Operation of Advisory Committees § 214.31 A.I.D. Advisory Committee Representative. (a) For each... with the Advisory Committee Management Officer and the General Counsel for decisions by the... Advisory Committee Management Officer. (5) Assuring that open meetings are accessible to the public; (6) As...

  12. 77 FR 4027 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  13. 76 FR 8358 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  14. 75 FR 57463 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  15. 78 FR 69839 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy...

  16. 77 FR 33449 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Office of Science... High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown...

  17. 76 FR 41234 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Department of Energy.../NSF High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86... Secretary; High Energy Physics Advisory Panel; U.S. Department of Energy; SC-25/ Germantown Building, 1000...

  18. 78 FR 12043 - DOE/NSF High Energy Physics Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... DEPARTMENT OF ENERGY DOE/NSF High Energy Physics Advisory Panel AGENCY: Office of Science... High Energy Physics Advisory Panel (HEPAP). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... INFORMATION CONTACT: John Kogut, Executive Secretary; High Energy Physics Advisory Panel; U.S. Department of...

  19. 78 FR 70623 - Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2009-0203] Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory Committee AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. [[Page...

  20. 29 CFR 102.136 - Establishment and utilization of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Establishment and utilization of advisory committees. 102... REGULATIONS, SERIES 8 Advisory Committees § 102.136 Establishment and utilization of advisory committees. Advisory committees may from time to time be established or utilized by the agency in the interest of...

  1. 29 CFR 102.136 - Establishment and utilization of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Establishment and utilization of advisory committees. 102... REGULATIONS, SERIES 8 Advisory Committees § 102.136 Establishment and utilization of advisory committees. Advisory committees may from time to time be established or utilized by the agency in the interest of...

  2. 76 FR 21349 - Science Advisory Board Staff Office; Request for Nominations of Candidates to the EPA's Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... serve on the chartered SAB in the following disciplines: Social, behavioral and decision sciences... ENVIRONMENTAL PROTECTION AGENCY [FRL-9296-4] Science Advisory Board Staff Office; Request for... Committee (CASAC), the Science Advisory Board (SAB), or SAB Committees described in this notice...

  3. 77 FR 45329 - Sabine Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... DEPARTMENT OF AGRICULTURE Forest Service Sabine Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Sabine Resource Advisory Committee will meet in [[Page 45330

  4. 77 FR 5258 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) Notice of Cancellation: This notice was published in the Federal Register on December 29,...

  5. 77 FR 8877 - World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention World Trade Center Health Program Scientific/Technical Advisory Committee (WTCHP STAC or Advisory Committee), National Institute for Occupational Safety and Health (NIOSH) Correction This notice was published in the Federal Register on January 31, 2012, Volume 77,...

  6. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  7. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  8. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  9. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  10. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  11. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  12. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  13. 10 CFR 7.10 - The NRC Advisory Committee Management Officer.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false The NRC Advisory Committee Management Officer. 7.10 Section 7.10 Energy NUCLEAR REGULATORY COMMISSION ADVISORY COMMITTEES § 7.10 The NRC Advisory Committee Management Officer. (a) The Chairman of the Commission or designee shall appoint an NRC Advisory Committee...

  14. 78 FR 21211 - Continuance of Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ...: Section 1. Continuing the President's Advisory Council on Faith-Based and Neighborhood Partnerships. The President's Advisory Council on Faith-Based and Neighborhood Partnerships, as set forth under the provisions...

  15. 76 FR 45504 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Virginia Resource Advisory Committee will meet in Roanoke, Virginia. The committee is authorized under the Secure...

  16. 77 FR 74099 - Reestablishment of Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ..., Health Promotion, and Integrative and Public Health. The Advisory Group on Prevention, Health Promotion, and Integrative and Public Health (Advisory Group), as set forth under the provisions of Executive...

  17. 77 FR 55201 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... teleconference of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory... Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown Building...

  18. 78 FR 6087 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... Biological and Environmental Research News from the Biological Systems Science and Climate and Environmental... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee...

  19. 77 FR 55200 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... News from the Biological Systems Science and Climate and Environmental Sciences Divisions Discussion of... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee...

  20. 78 FR 12043 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... teleconference of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory... of Science, Office of Biological and Environmental Research, SC-23/Germantown Building, 1000...

  1. 77 FR 28368 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee... Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown Building...

  2. Quantitative risk assessment of foods containing peanut advisory labeling.

    PubMed

    Remington, Benjamin C; Baumert, Joseph L; Marx, David B; Taylor, Steve L

    2013-12-01

    Foods with advisory labeling (i.e. "may contain") continue to be prevalent and the warning may be increasingly ignored by allergic consumers. We sought to determine the residual levels of peanut in various packaged foods bearing advisory labeling, compare similar data from 2005 and 2009, and determine any potential risk for peanut-allergic consumers. Of food products bearing advisory statements regarding peanut or products that had peanut listed as a minor ingredient, 8.6% and 37.5% contained detectable levels of peanut (>2.5 ppm whole peanut), respectively. Peanut-allergic individuals should be advised to avoid such products regardless of the wording of the advisory statement. Peanut was detected at similar rates and levels in products tested in both 2005 and 2009. Advisory labeled nutrition bars contained the highest levels of peanut and an additional market survey of 399 products was conducted. Probabilistic risk assessment showed the risk of a reaction to peanut-allergic consumers from advisory labeled nutrition bars was significant but brand-dependent. Peanut advisory labeling may be overused on some nutrition bars but prudently used on others. The probabilistic approach could provide the food industry with a quantitative method to assist with determining when advisory labeling is most appropriate. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. 75 FR 81277 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President...

  4. 76 FR 16787 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... was established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to...

  5. 78 FR 11650 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  6. 78 FR 732 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  7. 75 FR 57281 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-20

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President...

  8. 75 FR 11186 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President on...

  9. 76 FR 61364 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President on a...

  10. 78 FR 44954 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  11. 78 FR 21370 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President on a...

  12. 76 FR 36925 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the President...

  13. 77 FR 62240 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... established under the Energy Employees Occupational Illness Compensation Program Act of 2000 to advise the...

  14. 78 FR 61348 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... DEPARTMENT OF ENERGY Electricity Advisory Committee AGENCY: Department of Energy. ACTION: Notice of Cancellation of Open Meeting. SUMMARY: On September 11, 2013, in FR Doc. 2013-22119, on pages... October 2-3, 2013 of the Electricity Advisory Committee (78 FR 55692). This notice announces the...

  15. 78 FR 57174 - Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... recommended for inclusion on future Joint Board examinations in actuarial mathematics, pension law and... Advisory Committee on Actuarial Examinations. DATES: The meeting will be held on October 18, 2013, from 8.... SUPPLEMENTARY INFORMATION: Notice is hereby given that the Advisory Committee on Actuarial Examinations will...

  16. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false AGAR Advisories. 401.371 Section 401.371 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL AGRICULTURE ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR...

  17. 75 FR 53685 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... meeting of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory.... Department of Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown...

  18. 78 FR 34088 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Report from the Office of Biological and Environmental Research News from the Biological Systems Science... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Office of... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee...

  19. 77 FR 4028 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ... Report from the Office of Biological and Environmental Research News from the Biological Systems Science... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... meeting of the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory...

  20. 75 FR 6651 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... From the Office of Science Report From the Office of Biological and Environmental Research News From... DEPARTMENT OF ENERGY Biological and Environmental Research Advisory Committee AGENCY: Department... meeting of the Biological and Environmental Research Advisory Committee (BERAC). Federal Advisory...

  1. 75 FR 64720 - DOE/Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... DEPARTMENT OF ENERGY DOE/Advanced Scientific Computing Advisory Committee AGENCY: Department of... the Advanced Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L.... FOR FURTHER INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research; SC-21...

  2. 78 FR 68887 - Dodd-Frank Investor Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... Investor Advisory Committee; Meeting AGENCY: Securities and Exchange Commission. ACTION: Notice of Meeting of Securities and Exchange Commission Dodd- Frank Investor Advisory Committee. SUMMARY: The Securities and Exchange Commission Investor Advisory Committee, established pursuant to Section 911 of the...

  3. 77 FR 45345 - DOE/Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... Recompetition results for Scientific Discovery through Advanced Computing (SciDAC) applications Co-design Public... DEPARTMENT OF ENERGY DOE/Advanced Scientific Computing Advisory Committee AGENCY: Office of... the Advanced Scientific Computing Advisory Committee (ASCAC). The Federal Advisory Committee Act (Pub...

  4. 76 FR 52642 - Notice of Advisory Committee Closed Meeting; U.S. Strategic Command Strategic Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... DEPARTMENT OF DEFENSE Notice of Advisory Committee Closed Meeting; U.S. Strategic Command.... Strategic Command Strategic Advisory Group. DATES: November 1, 2011, from 8 a.m. to 5 p.m. and November 2..., intelligence, and policy-related issues to the Commander, U.S. Strategic Command, during the development of the...

  5. 76 FR 23787 - Ashley Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ashley Resource Advisory Committee will meet in Vernal, Utah. The committee is meeting as authorized under the...

  6. Overlapping topics in advisory reports issued by five well-established European National Immunization Technical Advisory Groups from 2011 to 2014.

    PubMed

    Nijsten, Daniëlle; Houweling, Hans; Durupt, Antoine; Adjagba, Alex

    2016-12-07

    National Immunization Technical Advisory Groups (NITAGs) are facing increasingly complex vaccination issues together with a lack of human resources for evidence assessment and data analysis. One way to reduce these burdens could be to share some of the preparatory work across NITAGs. We conducted an inventory of all the advisory reports issued by five well-established European NITAGs from 2011 to 2014 to assess overlaps in issues and activities. A total of 104 advisory reports were retrieved. Advisory reports on the same issues were compared to identify overlapping activities and processes. Advisory reports issued by the five NITAGs showed little overlap in issues and processes. A first step towards efficient collaboration would be to establish an independent platform to provide insight into each NITAG's work and to facilitate the exchange of agendas, assessment frameworks and evidence. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. 77 FR 65539 - Meeting of Global Markets Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... COMMODITY FUTURES TRADING COMMISSION Meeting of Global Markets Advisory Committee AGENCY... its Global Markets Advisory Committee (``GMAC''). DATES: The meeting will be held on November 7, 2012... title ``Global Markets Advisory Committee'' in any written statement you may submit. Any statements...

  8. 78 FR 31977 - NASA Applied Sciences Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-061] NASA Applied Sciences Advisory... Aeronautics and Space Administration (NASA) announces a meeting of the Applied Sciences Advisory Committee (ASAC). This Committee functions in an advisory capacity to the Director, Earth Science Division. The...

  9. 77 FR 45331 - Prince William Sound Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on proposals that...

  10. 76 FR 1130 - Prince William Sound Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource Advisory... conducted: The Prince William Sound Resource Advisory Committee (RAC) will be discussing and voting on...

  11. 75 FR 29781 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ...] President's National Security Telecommunications Advisory Committee AGENCY: National Protection and Programs... Security Telecommunications Advisory Committee (NSTAC) will be meeting by teleconference; the meeting will... telecommunications policy. Notice of this meeting is given under the Federal Advisory Committee Act (FACA), Public...

  12. 76 FR 13182 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... results of fact-finding activities conducted as part of a study of science integration supporting EPA... ENVIRONMENTAL PROTECTION AGENCY [FRL-9278-1] Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory Board Committee on Science Integration for Decision Making...

  13. 78 FR 38347 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety... Employees Occupational Illness Compensation Program Act of 2000 to advise the President on a variety of...

  14. 78 FR 28594 - Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... draft competitiveness report, and Ex-Im Bank economic impact policy update. Public Participation: The... EXPORT-IMPORT BANK OF THE UNITED STATES Advisory Committee Meeting ACTION: Notice of Open Meeting of the Advisory Committee of the Export- Import Bank of the United States (Ex-Im Bank). Time and...

  15. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  16. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  17. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  18. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  19. 18 CFR 701.59 - Advisory committees.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Advisory committees. 701.59 Section 701.59 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Headquarters Organization § 701.59 Advisory committees. The Council may establish standing and ad...

  20. 75 FR 54386 - Southeast Oregon Resource Advisory Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ...] Southeast Oregon Resource Advisory Council; Meeting AGENCY: Bureau of Land Management, Interior. ACTION: Southeast Oregon Resource Advisory Council. SUMMARY: Pursuant to the Federal Land Policy and Management Act... (BLM) Southeast Oregon Resource Advisory Council (SEORAC) will meet as indicated below: DATES: The...

  1. 75 FR 39703 - Meeting; Southeast Oregon Resource Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ...] Meeting; Southeast Oregon Resource Advisory Council AGENCY: Bureau of Land Management, Interior. ACTION: Southeast Oregon Resource Advisory Council. SUMMARY: Pursuant to the Federal Land Policy and Management Act... (BLM) Southeast Oregon Resource Advisory Council (SEORAC) will meet as indicated below: DATES: The...

  2. 77 FR 15362 - Efficiency and Renewables Advisory Committee (ERAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... DEPARTMENT OF ENERGY Efficiency and Renewables Advisory Committee (ERAC) AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy ACTION: Notice of open meeting. SUMMARY: This notice announces an open meeting of the Efficiency and Renewables Advisory Committee (ERAC). The Federal Advisory...

  3. 75 FR 32469 - Consumer Advisory Council; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... FEDERAL RESERVE SYSTEM Consumer Advisory Council; Notice of Meeting The Consumer Advisory Council... responsibilities under various consumer financial services laws and on other matters on which the Board seeks its... by sending written statements to Jennifer Kerslake, Secretary of the Consumer Advisory Council...

  4. 75 FR 43518 - Advanced Scientific Computing Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... DEPARTMENT OF ENERGY Advanced Scientific Computing Advisory Committee; Meeting AGENCY: Office of... Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...: Melea Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building; U. S...

  5. 77 FR 37389 - Renewal of the Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... COMMODITY FUTURES TRADING COMMISSION Renewal of the Technology Advisory Committee AGENCY... Commodity Futures Trading Commission has determined to renew the charter of its Technology Advisory... and identity that it is for the renewal of the Technology Advisory Committee. All comments must be...

  6. 78 FR 9883 - Lake Tahoe Basin Federal Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Lake Tahoe Basin Federal Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice; Solicitation of nominees to the Lake Tahoe Basin Federal Advisory Committee. SUMMARY: In accordance with the...) announces solicitation of nominees to fill vacancies on the Lake Tahoe Basin Federal Advisory Committee...

  7. 77 FR 51791 - DOE/NSF Nuclear Science Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... DEPARTMENT OF ENERGY DOE/NSF Nuclear Science Advisory Committee AGENCY: Department of Energy.../NSF Nuclear Science Advisory Committee (NSAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86... on scientific priorities within the field of basic nuclear science research. Tentative Agenda: Agenda...

  8. 75 FR 6651 - DOE/NSF Nuclear Science Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... DEPARTMENT OF ENERGY DOE/NSF Nuclear Science Advisory Committee AGENCY: Department of Energy.../NSF Nuclear Science Advisory Committee (NSAC). Federal Advisory Committee Act (Pub. L. 92- 463, 86... on scientific priorities within the field of basic nuclear science research. Tentative Agenda: Agenda...

  9. 75 FR 16159 - President's National Security Telecommunications Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ...] President's National Security Telecommunications Advisory Committee AGENCY: National Communications System... Telecommunications Advisory Committee (NSTAC) will hold its annual meeting on May 6, 2010. The meeting will be open... preparedness telecommunications policy. Notice of this meeting is given under the Federal Advisory Committee...

  10. 75 FR 26918 - Siuslaw Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Siuslaw Resource Advisory Committee will meet in Corvallis, OR. The purpose of the meeting is to Review RAC FY10...

  11. 77 FR 11547 - Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Advisory Board on Radiation and Worker Health (ABRWH or Advisory Board), National Institute for Occupational Safety and Health (NIOSH) The meeting scheduled to convene on February 28-29, 2012 was published in the...

  12. 77 FR 70543 - Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    .... PHMSA-2009-0203] Pipeline Safety: Meeting of the Gas Pipeline Advisory Committee and the Liquid Pipeline..., and safety policies for natural gas pipelines and for hazardous liquid pipelines. Both committees were...: Notice of advisory committee meeting. SUMMARY: This notice announces a public meeting of the Gas Pipeline...

  13. 75 FR 27825 - Arts Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory..., notice is hereby given that one meeting of the Arts Advisory Panel to the National Council on the Arts..., evaluation, and recommendations on financial assistance under the National Foundation on the Arts and the...

  14. 76 FR 50499 - Arts Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory..., notice is hereby given that one meeting of the Arts Advisory Panel to the National Council on the Arts..., evaluation, and recommendations on financial assistance under the National Foundation on the Arts and the...

  15. 75 FR 39201 - MedBow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... DEPARTMENT OF AGRICULTURE Forest Service MedBow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... and Community Self-Determination Act (Pub. L. 110-343) and in compliance with the Federal Advisory...

  16. 75 FR 52304 - MedBow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... DEPARTMENT OF AGRICULTURE Forest Service MedBow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... Community Self-Determination Act (Pub. L. 110- 343) and in compliance with the Federal Advisory Committee...

  17. 76 FR 12016 - MedBow-Routt Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... DEPARTMENT OF AGRICULTURE Forest Service MedBow-Routt Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The MedBow-Routt Resource Advisory Committee will meet... Community Self-Determination Act (Pub. L. 110- 343) and in compliance with the Federal Advisory Committee...

  18. 77 FR 8214 - Black Hills National Forest Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... DEPARTMENT OF AGRICULTURE Forest Service Black Hills National Forest Advisory Board AGENCY: USDA Forest Service. ACTION: Notice of intent to re-establish the Black Hills National Forest Advisory Board...-establish the Black Hills National Forest Advisory Board (Board). The purpose is to obtain advice and...

  19. 78 FR 14351 - Invasive Species Advisory Committee; Meeting Cancellation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee; Meeting... meeting of the Invasive Species Advisory Committee (ISAC) scheduled for Thursday, March 7, 2013 and Friday... invasive species experts and stakeholders from across the nation. The purpose of the Advisory Committee is...

  20. 75 FR 65447 - Prince of Wales Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Ranger District 504 9th Street, Craig, Alaska. Send written comments to Prince of Wales Resource Advisory...

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