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Sample records for sachs form factors

  1. Kerr metric in Bondi-Sachs form

    SciTech Connect

    Bishop, Nigel T.; Venter, Liebrecht R.

    2006-04-15

    A metric representing the Kerr geometry has been obtained by Pretorius and Israel. We make coordinate transformations on this metric, to bring it into Bondi-Sachs form. We investigate the behavior of the metric near the axis of symmetry and confirm elementary flatness, and we also confirm that it is asymptotic to the Bondi-Sachs form of the Schwarzschild geometry. The results obtained here are needed so that numerical relativity codes based on the characteristic formalism can be applied to a situation that contains a rotating black hole.

  2. Hill-Sachs Off-track Lesions as Risk Factor for Recurrence of Instability After Arthroscopic Bankart Repair.

    PubMed

    Locher, Joel; Wilken, Frauke; Beitzel, Knut; Buchmann, Stefan; Longo, Umile Giuseppe; Denaro, Vincenzo; Imhoff, Andreas B

    2016-10-01

    To evaluate the effect of "off-track" Hill-Sachs lesions, according to the glenoid track concept, as a risk factor for recurrent instability and need for revision surgery after arthroscopic Bankart repair. We retrospectively reviewed 254 patients with anteroinferior glenohumeral instability who were managed with an arthroscopic stabilization procedure between 2006 and 2013. Preoperative magnetic resonance imaging and/or computed tomography scans were available for 100 of these patients to calculate the glenoid track and the presence of "on-track" or off-track Hill-Sachs lesions. Recurrence of instability was evaluated at a mean follow-up of 22.4 months. Of 100 patients whose magnetic resonance imaging and/or computed tomography scans were available, 88 had an on-track Hill-Sachs lesion and 12 had an off-track Hill-Sachs lesion. Revision surgery for recurrent instability was performed in 5 patients (6%) with an on-track Hill-Sachs lesion and in 4 patients (33%) with an off-track Hill-Sachs lesion (odds ratio, 8.3; 95% confidence interval, 1.85-37.26; P = .006). An off-track Hill-Sachs lesion is a significant and important risk factor for recurrence of instability and need for revision surgery after arthroscopic Bankart repair when compared with an on-track Hill-Sachs lesion. Level IV, prognostic case series. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  3. Substrate reduction therapy in the infantile form of Tay-Sachs disease.

    PubMed

    Bembi, B; Marchetti, F; Guerci, V I; Ciana, G; Addobbati, R; Grasso, D; Barone, R; Cariati, R; Fernandez-Guillen, L; Butters, T; Pittis, M G

    2006-01-24

    Substrate reduction therapy (SRT) with miglustat has been proposed for treatment of some lysosomal storage disorders. Based on the positive experience in Gaucher disease and experimental data in Tay-Sachs (TSD) and Sandhoff animal models, the authors investigated the clinical efficacy of SRT in two patients with infantile TSD. SRT could not arrest the patients' neurologic deterioration. However, a significant drug concentration in CSF as well as macrocephaly prevention were observed.

  4. Diagnosis and molecular characterization of non-classic forms of Tay-Sachs disease in Brazil.

    PubMed

    Rozenberg, R; Kok, F; Burin, M G; Sá Miranda, M C; Vasques, C; Henriques-Souza, A M M; Giugliani, R; Vainzof, Mariz; Pereira, L V

    2006-06-01

    Molecular analysis of five Brazilian families, including eight patients presenting with nonclassic Tay-Sachs disease, was performed to identify frequent causative mutations and their correlation with clinical course. Three patients were affected by the B1 subacute variant and were shown to carry the R178H mutation (the DN allele), which is also common among Portuguese patients. Two of them were compound heterozygotes, whereas the third presented with the mutation in both alleles. Since Brazil was a Portuguese colony for over two centuries, common ancestry might be the probable explanation. The fourth patient presented with a juvenile phenotype and carries the R499H mutation, which has been reported only once worldwide and is associated with residual enzyme activity, responsible for a slower clinical course. The fifth family, of an Ashkenazi Jewish background, showed an extensive intrafamilial clinical variability among three affected sibs presenting with muscle atrophy, ataxia, and psychiatric symptoms. They were first diagnosed as having atypical spinal muscular atrophy and, subsequently, spinocerebellar ataxia, but, recently, the diagnosis of late-onset Tay-Sachs disease was confirmed based on reduced plasma hexosaminidase A activity and the G269S/InsTATC1278 genotype. It is therefore highly recommended to test patients with a similar clinical history for Tay-Sachs disease. In the same family, one first cousin committed suicide at the age of 24 years, presenting with a clinical phenotype that suggested an undiagnosed case and highlighting the effect of the intrafamilial clinical variability in delaying a prompt diagnosis. It is now recognized that his parents are, in fact, a carrier couple. Additionally, another relative had been previously identified as a heterozygote in a Tay-Sachs disease screening program, but the information was not shared among the family. Since this information might anticipate diagnosis and genetic counseling, it is advisable that

  5. Tay-Sachs Disease

    MedlinePlus

    Tay-Sachs disease is a rare, inherited disease. It is a type of lipid metabolism disorder. It causes too ... cells, causing mental and physical problems. . Infants with Tay-Sachs disease appear to develop normally for the first few ...

  6. Tay-Sachs - resources

    MedlinePlus

    The following organizations provide information on Tay-Sachs disease : US National Library of Medicine -- ghr.nlm.nih.gov/condition/tay-sachs-disease March of Dimes -- www.marchofdimes.com/pnhec/4439_1227. ...

  7. Tay-Sachs Disease

    MedlinePlus

    ... Habits for TV, Video Games, and the Internet Tay-Sachs Disease KidsHealth > For Parents > Tay-Sachs Disease Print A A A What's in this article? ... can interfere with growth. But a baby with Tay-Sachs disease is born without one of those important enzymes, ...

  8. Tay-Sachs Disease

    MedlinePlus

    ... Old Feeding Your 1- to 2-Year-Old Tay-Sachs Disease KidsHealth > For Parents > Tay-Sachs Disease A A A What's in this article? Who ... can interfere with growth. But a baby with Tay-Sachs disease is born without one of those important enzymes, ...

  9. Tay-Sachs disease

    MedlinePlus

    ... testing the amniotic fluid can diagnose Tay-Sachs disease in the womb. ... Kwon JM. Neurodegenerative disorders of childhood. In: Kliegman RM, ... and Thompson Genetics in Medicine . 8th ed. Philadelphia, PA: ...

  10. Electromagnetic nucleon form factors

    SciTech Connect

    Bender, A.; Roberts, C.D.; Frank, M.R.

    1995-08-01

    The Dyson-Schwinger equation framework is employed to obtain expressions for the electromagnetic nucleon form factor. In generalized impulse approximation the form factor depends on the dressed quark propagator, the dressed quark-photon vertex, which is crucial to ensuring current conservation, and the nucleon Faddeev amplitude. The approach manifestly incorporates the large space-like-q{sup 2} renormalization group properties of QCD and allows a realistic extrapolation to small space-like-q{sup 2}. This extrapolation allows one to relate experimental data to the form of the quark-quark interaction at small space-like-q{sup 2}, which is presently unknown. The approach provides a means of unifying, within a single framework, the treatment of the perturbative and nonperturbative regimes of QCD. The wealth of experimental nucleon form factor data, over a large range of q{sup 2}, ensures that this application will provide an excellent environment to test, improve and extend our approach.

  11. The metabolism of Tay-Sachs ganglioside: catabolic studies with lysosomal enzymes from normal and Tay-Sachs brain tissue

    PubMed Central

    Tallman, John F.; Johnson, William G.; Brady, Roscoe O.

    1972-01-01

    The catabolism of Tay-Sachs ganglioside, N-acetylgalactosaminyl- (N-acetylneuraminosyl) -galactosylglucosylceramide, has been studied in lysosomal preparations from normal human brain and brain obtained at biopsy from Tay-Sachs patients. Utilizing Tay-Sachs ganglioside labeled with 14C in the N-acetylgalactosaminyl portion or 3H in the N-acetylneuraminosyl portion, the catabolism of Tay-Sachs ganglioside may be initiated by either the removal of the molecule of N-acetylgalactosamine or N-acetylneuraminic acid. The activity of the N-acetylgalactosamine-cleaving enzyme (hexosaminidase) is drastically diminished in such preparations from Tay-Sachs brain whereas the activity of the N-acetylneuraminic acid-cleaving enzyme (neuraminidase) is at a normal level. Total hexosaminidase activity as measured with an artificial fluorogenic substrate is increased in tissues obtained from patients with the B variant form of Tay-Sachs disease and it is virtually absent in the O-variant patients. The addition of purified neuraminidase and various purified hexosaminidases exerted only a minimal synergistic effect on the hydrolysis of Tay-Sachs ganglioside in the lysosomal preparations from the control or patient with the O variant of Tay-Sachs disease. Images PMID:4639018

  12. Analytic pion form factor

    NASA Astrophysics Data System (ADS)

    Lomon, Earle L.; Pacetti, Simone

    2016-09-01

    The pion electromagnetic form factor and two-pion production in electron-positron collisions are simultaneously fitted by a vector dominance model evolving to perturbative QCD at large momentum transfer. This model was previously successful in simultaneously fitting the nucleon electromagnetic form factors (spacelike region) and the electromagnetic production of nucleon-antinucleon pairs (timelike region). For this pion case dispersion relations are used to produce the analytic connection of the spacelike and timelike regions. The fit to all the data is good, especially for the newer sets of timelike data. The description of high-q2 data, in the timelike region, requires one more meson with ρ quantum numbers than listed in the 2014 Particle Data Group review.

  13. Nucleon Electromagnetic Form Factors

    SciTech Connect

    Kees de Jager

    2004-08-01

    Although nucleons account for nearly all the visible mass in the universe, they have a complicated structure that is still incompletely understood. The first indication that nucleons have an internal structure, was the measurement of the proton magnetic moment by Frisch and Stern (1933) which revealed a large deviation from the value expected for a point-like Dirac particle. The investigation of the spatial structure of the nucleon, resulting in the first quantitative measurement of the proton charge radius, was initiated by the HEPL (Stanford) experiments in the 1950s, for which Hofstadter was awarded the 1961 Nobel prize. The first indication of a non-zero neutron charge distribution was obtained by scattering thermal neutrons off atomic electrons. The recent revival of its experimental study through the operational implementation of novel instrumentation has instigated a strong theoretical interest. Nucleon electro-magnetic form factors (EMFFs) are optimally studied through the exchange of a virtual photon, in elastic electron-nucleon scattering. The momentum transferred to the nucleon by the virtual photon can be selected to probe different scales of the nucleon, from integral properties such as the charge radius to scaling properties of its internal constituents. Polarization instrumentation, polarized beams and targets, and the measurement of the polarization of the recoiling nucleon have been essential in the accurate separation of the charge and magnetic form factors and in studies of the elusive neutron charge form factor.

  14. Electromagnetic pion form factor

    SciTech Connect

    Roberts, C.D.

    1995-08-01

    A phenomenological Dyson-Schwinger/Bethe-Salpeter equation approach to QCD, formalized in terms of a QCD-based model field theory, the Global Color-symmetry Model (GCM), was used to calculate the generalized impulse approximation contribution to the electromagnetic pion form factor at space-like q{sup 2} on the domain [0,10] GeV{sup 2}. In effective field theories this form factor is sometimes understood as simply being due to Vector Meson Dominance (VMD) but this does not allow for a simple connection with QCD where the VMD contribution is of higher order than that of the quark core. In the GCM the pion is treated as a composite bound state of a confined quark and antiquark interacting via the exchange of colored vector-bosons. A direct study of the quark core contribution is made, using a quark propagator that manifests the large space-like-q{sup 2} properties of QCD, parameterizes the infrared behavior and incorporates confinement. It is shown that the few parameters which characterize the infrared form of the quark propagator may be chosen so as to yield excellent agreement with the available data. In doing this one directly relates experimental observables to properties of QCD at small space-like-q{sup 2}. The incorporation of confinement eliminates endpoint and pinch singularities in the calculation of F{sub {pi}}(q{sup 2}). With asymptotic freedom manifest in the dressed quark propagator the calculation yields q{sup 4}F{sub {pi}}(q{sup 2}) = constant, up to [q{sup 2}]- corrections, for space-like-q{sup 2} {approx_gt} 35 GeV{sup 2}, which indicates that soft, nonperturbative contributions dominate the form factor at presently accessible q{sup 2}. This means that the often-used factorization Ansatz fails in this exclusive process. A paper describing this work was submitted for publication. In addition, these results formed the basis for an invited presentation at a workshop on chiral dynamics and will be published in the proceedings.

  15. Venus - Sag Caldera Sachs Patera

    NASA Image and Video Library

    1996-11-20

    This image from NASA Magellan spacecraft is of Sachs Patera on Venus, centered at 49 degrees north, 334 degrees east. Defined as a sag-caldera, Sachs is an elliptical depression 130 meters (81 feet) in depth, spanning 40 kilometers (25 miles) in width along its longest axis. The morphology implies that a chamber of molten material drained and collapsed, forming a depression surrounded by concentric scarps spaced 2-to-5 kilometers (1.2- to-3 miles) apart. The arc-shaped set of scarps, extending out to the north from the prominent ellipse, is evidence for a separate episode of withdrawal; the small lobe-shaped extension to the southwest may represent an additional event. Solidified lava flows 10-to-25 kilometers (6-to-16 miles) long, give the caldera its flower-like appearance. The flows are a lighter tone of gray in the radar data because the lava is blockier in texture and consequently returns more radar waves. Much of the lava, which was evacuated from the chamber, probably traveled to other locations underground, while some of it may have surfaced further south. This is unlike calderas on Earth, where a rim of lava builds up in the immediate vicinity of the caldera. http://photojournal.jpl.nasa.gov/catalog/PIA00473

  16. Venus - Sag Caldera 'Sachs Patera

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This image of Sachs Patera on Venus is centered at 49 degrees north, 334 degrees east. Defined as a sag-caldera, Sachs is an elliptical depression 130 meters (81 feet) in depth, spanning 40 kilometers (25 miles) in width along its longest axis. The morphology implies that a chamber of molten material drained and collapsed, forming a depression surrounded by concentric scarps spaced 2-to-5 kilometers (1.2- to-3 miles) apart. The arc-shaped set of scarps, extending out to the north from the prominent ellipse, is evidence for a separate episode of withdrawal; the small lobe-shaped extension to the southwest may represent an additional event. Solidified lava flows 10-to-25 kilometers (6-to-16 miles) long, give the caldera its flower-like appearance. The flows are a lighter tone of gray in the radar data because the lava is blockier in texture and consequently returns more radar waves. Much of the lava, which was evacuated from the chamber, probably traveled to other locations underground, while some of it may have surfaced further south. This is unlike calderas on Earth, where a rim of lava builds up in the immediate vicinity of the caldera.

  17. Pion form factor

    SciTech Connect

    Ryong Ji, C.; Pang, A.; Szczepaniak, A.

    1994-04-01

    It is pointed out that the correct criterion to define the legal PQCD contribution to the exclusive processes in the lightcone perturbative expansion should be based on the large off-shellness of the lightcone energy in the intermediate states. In the lightcone perturbative QCD calculation of the pion form factor, the authors find that the legal PQCD contribution defined by the lightcone energy cut saturates in the smaller Q{sup 2} region compared to that defined by the gluon four-momentum square cut. This is due to the contribution by the highly off-energy-shell gluons in the end point regions of the phase space, indicating that the gluon four-momentum-square cut may have cut too much to define the legal PQCD.

  18. Nucleon Electromagnetic Form Factors

    SciTech Connect

    Marc Vanderhaeghen; Charles Perdrisat; Vina Punjabi

    2007-10-01

    There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has greatly improved by performing double polarization experiments, in comparison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at JLab, MAMI, and MIT-Bates. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed, including the recent progress in the determination of the valence quark generalized parton distributions of the nucleon, as well as the steady rate of improvements made in the lattice QCD calculations.

  19. The Val{sup 192}Leu mutation in the {alpha}-subunit of {beta}-hexosaminidase A is not associated with the B1-variant form of Tay-Sachs disease

    SciTech Connect

    Hou, Y.; Vavougios, G.; Hinek, A.

    1996-07-01

    Substitution mutations adversely affecting the {alpha}-subunit of {beta}-hexosaminidase A ({alpha}{beta}) (EC 3.2.1.52) result in Tay-Sachs disease. The majority affect the initial folding of the pro-{alpha} chain in the endoplasmic reticulum, resulting in its retention and degradation. A much less common occurrence is a mutation that specifically affects an {open_quotes}active-site{close_quotes} residue necessary for substrate binding and/or catalysis. In this case, hexosaminidase A is present in the lysosome, but it lacks all {alpha}-specific activity. This biochemical phenotype is referred to as the {open_quotes}B1-variant form{close_quotes} of Tay-Sachs disease. Kinetic analysis of suspected B1-variant mutations is complex because hexosaminidase A is heterodimeric and both subunits possess similar active sites. In this report, we examine a previously identified B1-variant mutation, {alpha}-Val{sup 192}Leu. Chinese hamster ovary cells were permanently cotransfected with an {alpha}-cDNA-construct encoding the substitution and a mutant {beta}-cDNA ({beta}-Arg{sup 211}Lys), encoding a {beta}-subunit that is inactive but normal in all other respects. We were surprised to find that the Val{sup 192}Leu substitution produced a pro-{alpha} chain that did not form {alpha}-{beta} dimers and was not transported to the lysosome. Finally, we reexamined the hexosaminidase activity and protein levels in the fibroblasts from the original patient. These data were also not consistent with the biochemical phenotype of the B1 variant of Tay-Sachs disease previously reported to be present. Thus, we conclude that the Val{sup 192}Leu substitution does not specifically affect the {alpha}-active site. 23 refs., 4 figs., 2 tabs.

  20. The Val192Leu mutation in the alpha-subunit of beta-hexosaminidase A is not associated with the B1-variant form of Tay-Sachs disease.

    PubMed Central

    Hou, Y.; Vavougios, G.; Hinek, A.; Wu, K. K.; Hechtman, P.; Kaplan, F.; Mahuran, D. J.

    1996-01-01

    Substitution mutations adversely affecting the alpha-subunit of beta-hexosaminidase A (alphabeta) (EC 3.2.1.52) result in Tay-Sachs disease. The majority affect the initial folding of the pro-alpha chain in the endoplasmic reticulum, resulting in its retention and degradation. A much less common occurrence is a mutation that specifically affects an "active-site" residue necessary for substrate binding and/or catalysis. In this case, hexosaminidase A is present in the lysosome, but it lacks all alpha-specific activity. This biochemical phenotype is referred to as the "B1-variant form" of Tay-Sachs disease. Kinetic analysis of suspected B1-variant mutations is complex because hexosaminidase A is heterodimeric and both subunits possess similar active sites. In this report, we examine a previously identified B1-variant mutation, alpha-Val192Leu. Chinese hamster ovary cells were permanently cotransfected with an alpha-cDNA-construct encoding the substitution and a mutant beta-cDNA (beta-Arg211Lys), encoding a beta-subunit that is inactive but normal in all other respects. We were surprised to find that the Val192Leu substitution, produced a pro-alpha chain that did not form alpha-beta dimers and was not transported to the lysosome. Finally, we reexamined the hexosaminidase activity and protein levels in the fibroblasts from the original patient. These data were also not consistent with the biochemical phenotype of the B1 variant of Tay-Sachs disease previously reported to be present. Thus, we conclude that the Val192Leu substitution does not specifically affect the alpha-active site. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:8659543

  1. Electromagnetic Hadronic Form-Factors

    SciTech Connect

    Robert Edwards

    2004-06-01

    We present a calculation of the nucleon electromagnetic form-factors as well as the pion and rho to pion transition form-factors in a hybrid calculation with domain wall valence quarks and improved staggered (Asqtad) sea quarks.

  2. Nucleon electromagnetic form factors using lattice simulations at the physical point

    NASA Astrophysics Data System (ADS)

    Alexandrou, C.; Constantinou, M.; Hadjiyiannakou, K.; Jansen, K.; Kallidonis, Ch.; Koutsou, G.; Vaquero Aviles-Casco, A.

    2017-08-01

    We present results for the nucleon electromagnetic form factors using an ensemble of maximally twisted mass clover-improved fermions with pion mass of about 130 MeV. We use multiple sink-source separations and three analysis methods to probe ground-state dominance. We evaluate both the connected and disconnected contributions to the nucleon matrix elements. We find that the disconnected quark loop contributions to the isoscalar matrix elements are small, giving an upper bound of up to 2% of the connected and smaller than its statistical error. We present results for the isovector and isoscalar electric and magnetic Sachs form factors and the corresponding proton and neutron form factors. By fitting the momentum dependence of the form factors to a dipole form or to the z expansion, we extract the nucleon electric and magnetic radii, as well as the magnetic moment. We compare our results to experiment as well as to other recent lattice QCD calculations.

  3. Exact solution of the Einstein-Skyrme model in a Kantowski-Sachs spacetime

    NASA Astrophysics Data System (ADS)

    Paliathanasis, Andronikos; Tsamparlis, Michael

    2017-04-01

    We consider a Skyrme fluid with a constant radial profile in locally rotational Kantowski-Sachs spacetime. The Skyrme fluid is an anisotropic fluid with zero heat flux and with an equation of state parameter wS that |ws | ≤ 1/3. From the Einstein field equations we define the Wheeler-DeWitt equation. For the last equation we perform a Lie symmetry classification and we determine the invariant solutions for the wavefunction of the model. Moreover from the Lie symmetries of the Wheeler-DeWitt equation we construct Noetherian conservation laws for the field equations which we use in order to write the solution in closed form. We show that all of the cosmological parameters are expressed in terms of the scale factor of the two dimensional sphere of the Kantowski-Sachs spacetime. Finally from the application of Noether's theorem for the Wheeler-DeWitt equation we derive conservation laws for the wavefunction of the universe.

  4. Strange nucleon form-factors

    NASA Astrophysics Data System (ADS)

    Maas, F. E.; Paschke, K. D.

    2017-07-01

    A broad program measuring parity-violation in electron-nuclear scattering has now provided a large set of precision data on the weak-neutral-current form-factors of the proton. Under comparison with well-measured electromagnetic nucleon form-factors, these measurements reveal the role of the strange quark sea on the low-energy interactions of the proton through the strange-quark-flavor vector form-factors. This review will describe the experimental program and the implications of the global data for the strange-quark vector form-factors. We present here a new fit to the world data.

  5. Learning about Tay-Sachs Disease

    MedlinePlus

    ... genetic terms used on this page. Learning About Tay-Sachs Disease What do we know about heredity and Tay- ... Information What Do We Know About Heredity and Tay-Sachs Disease? Tay-Sachs disease (TSD) is a fatal genetic ...

  6. Genetics Home Reference: Tay-Sachs disease

    MedlinePlus

    ... Facebook Twitter Home Health Conditions Tay-Sachs disease Tay-Sachs disease Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Tay-Sachs disease is a rare inherited disorder that progressively destroys ...

  7. Coordinate-Invariant Lyddane-Sachs-Teller Relationship for Polar Vibrations in Materials with Monoclinic and Triclinic Crystal Systems

    NASA Astrophysics Data System (ADS)

    Schubert, Mathias

    2016-11-01

    A coordinate-invariant generalization of the Lyddane-Sachs-Teller relation is presented for polar vibrations in materials with monoclinic and triclinic crystal systems. The generalization is derived from an eigendielectric displacement vector summation approach, which is equivalent to the microscopic Born-Huang description of polar lattice vibrations in the harmonic approximation. An expression for a general oscillator strength is also described for materials with monoclinic and triclinic crystal systems. A generalized factorized form of the dielectric response characteristic for monoclinic and triclinic materials is proposed. The generalized Lyddane-Sachs-Teller relation is found valid for monoclinic β -Ga2O3 , where accurate experimental data became available recently from a comprehensive generalized ellipsometry investigation [Phys. Rev. B 93, 125209 (2016)]. Data for triclinic crystal systems can be measured by generalized ellipsometry as well, and are anticipated to become available soon and results can be compared with the generalized relations presented here.

  8. Coordinate-Invariant Lyddane-Sachs-Teller Relationship for Polar Vibrations in Materials with Monoclinic and Triclinic Crystal Systems.

    PubMed

    Schubert, Mathias

    2016-11-18

    A coordinate-invariant generalization of the Lyddane-Sachs-Teller relation is presented for polar vibrations in materials with monoclinic and triclinic crystal systems. The generalization is derived from an eigendielectric displacement vector summation approach, which is equivalent to the microscopic Born-Huang description of polar lattice vibrations in the harmonic approximation. An expression for a general oscillator strength is also described for materials with monoclinic and triclinic crystal systems. A generalized factorized form of the dielectric response characteristic for monoclinic and triclinic materials is proposed. The generalized Lyddane-Sachs-Teller relation is found valid for monoclinic β-Ga_{2}O_{3}, where accurate experimental data became available recently from a comprehensive generalized ellipsometry investigation [Phys. Rev. B 93, 125209 (2016)]. Data for triclinic crystal systems can be measured by generalized ellipsometry as well, and are anticipated to become available soon and results can be compared with the generalized relations presented here.

  9. The death of Sadie Sachs.

    PubMed

    Lynaugh, J

    1991-01-01

    Helplessly watching a woman die from a self-induced abortion forever changed the life of Margaret Sanger, the women who brought the issue of birth control to the forefront of feminist and health issues. In 912, Sanger, wide and mother of 3, practiced nursing in New York City. One day she accompanied a physician to an emergency at the house of Jake Sachs, a 28 year-old truck driver and husband of Sadie Sachs. Sadie was very ill, the product of a self-induced abortion. Sanger nursed Sadie for several weeks until she recovered, but as Sanger prepared to make her leave, Sadie said that another pregnancy would end her life. Sanger asked the physician if there was anything that could be done, but he responded negatively. Three months later, the Sachs household had another emergency, and Sanger promptly arrived, already knowing what she would find. It was too late to save Sadie Sachs. This incident changed her life. She renounced the nursing profession for activism, but was unable to convince her feminist and socialist friends of the need for controlling family size. So she began studying all there was to know on the subject, and came to coin the term "birth control". Later she started publishing a magazine designed to educate on birth control, but the authorities put an end to it, since the law prohibited anyone from providing information to prevent conception for any reason. She fled to England, but returned to open a clinic in Brooklyn that distributed information on birth control. The clinic served hundreds of people, until it was raided by police on the 9th day of operation. Sanger went to jail. Nonetheless, her pioneering efforts did begin the acknowledgement of the need for birth control. And now, public opinion stands on the side of Margaret Sanger.

  10. Well-posed ADM equivalent of the Bondi-Sachs problem

    SciTech Connect

    Frittelli, Simonetta

    2006-06-15

    Every well-posed hyperbolic problem has an associated characteristic representation. In the case of the Einstein equations, traditionally, characteristic problems have been stated in the Bondi-Sachs form, whereas initial-value problems have been represented in the ADM form, both being looked upon as independent versions of the Einstein equations. Under the restriction of spherical symmetry, we provide an ADM version of the Einstein equations that functions as the initial-value representation of the Bondi-Sachs equations. The ADM version allows us to interpret the Bondi-Sachs variables precisely in terms of characteristic fields of the Cauchy problem. The Bondi-Sachs version thus leads us to a version of the Cauchy problem that is first order in time (with no need for reduction) and automatically well posed.

  11. Form factors from lattice QCD

    SciTech Connect

    Dru Renner

    2012-04-01

    Precision computation of hadronic physics with lattice QCD is becoming feasible. The last decade has seen precent-level calculations of many simple properties of mesons, and the last few years have seen calculations of baryon masses, including the nucleon mass, accurate to a few percent. As computational power increases and algorithms advance, the precise calculation of a variety of more demanding hadronic properties will become realistic. With this in mind, I discuss the current lattice QCD calculations of generalized parton distributions with an emphasis on the prospects for well-controlled calculations for these observables as well. I will do this by way of several examples: the pion and nucleon form factors and moments of the nucleon parton and generalized-parton distributions.

  12. Transition Form Factor from CLAS

    NASA Astrophysics Data System (ADS)

    Park, K.

    2009-01-01

    The excitation of nucleon resonances in electromagnetic interaction has long been studied. The study of resonances helps us to understand the long- and short- range structures of the nucleon and its excited states in terms of quark confinement. While the existing data of the low-lying resonances are consistent with the well-studied SU(6) ⊗ O(3) constituent quark model classification, many open questions still remain. Exclusive electro-production is one of the best ways to investigate nucleon resonances. The exclusive electro-production process e→p→enπ was measured in the photon virtuality range Q2 = 1.7 - 4.5 GeV 2 and the invariant mass range for the n π+ system of W = 1.15 - 1.7 GeV using the CEBAF Large Acceptance Spectrometer. For the first time, these kinematics are probed in exclusive π+ production from protons with nearly full coverage in the azimuthal and polar angles of the n π+ center-of-mass system. The n π+ channel has particular sensitivity to the isospin 1/2 > excited nucleon states, and together with the p π0 final state will serve to determine the transition form factors of a large number of resonances. The largest discrepancy between these results and present modes was seen in the σ structure function. Thanks to a large volume of data (31,295 cross section and 4,184 asymmetry data points), a reduced set of structure functions and Legendre polynomial moments are presented which are obtained in model-independent fits to the differential cross sections. In this paper, I will discuss the transition form factors of the nucleon resonances in terms of helicity amplitudes.

  13. The neutron electric form factor to Q² = 1.45 (GeV/c)²

    SciTech Connect

    Plaster, Bradley

    2004-02-01

    The nucleon elastic electromagnetic form factors are fundamental quantities needed for an understanding of nucleon and nuclear electromagnetic structure. The evolution of the Sachs electric and magnetic form factors with Q2, the square of the four-momentum transfer, is related to the distribution of charge and magnetization within the nucleon. High precision measurements of the nucleon form factors are essential for stringent tests of our current theoretical understanding of confinement within the nucleon. Measurements of the neutron form factors, in particular, those of the neutron electric form factor, have been notoriously difficult due to the lack of a free neutron target and the vanishing integral charge of the neutron. Indeed, a precise measurement of the neutron electric form factor has eluded experimentalists for decades; however, with the advent of high duty-factor polarized electron beam facilities, experiments employing polarization degrees of freedom have finally yielded the first precise measurements of this fundamental quantity. Following a general overview of the experimental and theoretical status of the nucleon form factors, a detailed description of an experiment designed to extract the neutron electric form factor from measurements of the neutron's recoil polarization in quasielastic 2H(e, e')1H scattering is presented. The experiment described here employed the Thomas Jefferson National Accelerator Facility's longitudinally polarized electron beam, a magnetic spectrometer for detection of the scattered electron, and a neutron polarimeter designed specifically for this experiment. Measurements were conducted at three Q2 values of 0.45, 1.13, and 1.45 (GeV/c)2, and the final results extracted from an analysis of the data acquired in this experiment are reported and compared with recent theoretical predictions for the nucleon form factors.

  14. Bondi-Metzner-Sachs bootstrap

    NASA Astrophysics Data System (ADS)

    Bagchi, Arjun; Gary, Mirah; Zodinmawia

    2017-07-01

    We initiate a study of the bootstrap program for field theories with Bondi-Metzner-Sachs (BMS) symmetry. Specifically, we look at two-dimensional field theories with BMS3 symmetry, and using the highest weight representations we construct the BMS bootstrap equation by formulating the notion of crossing symmetry in the four-point functions of these field theories. In the limit of large central charge, we find analytic expressions for the BMS blocks that are the basic ingredients for the solution of the bootstrap equation. This constitutes, to the best of our knowledge, the first example of the formulation and significant steps toward the solution of a bootstrap equation in a theory which is not a relativistic conformal field theory.

  15. Testing Gravity Against Early Time Integrated Sachs-Wolfe Effect

    SciTech Connect

    Zhang, Pengjie; /Shanghai, Astron. Observ. /Fermilab

    2005-11-01

    A generic prediction of general relativity is that the cosmological linear density growth factor D is scale independent. But in general, modified gravities do not preserve this signature. A scale dependent D can cause time variation in gravitational potential at high redshifts and provides a new cosmological test of gravity, through early time integrated Sachs-Wolfe (ISW) effect-large scale structure (LSS) cross correlation. We demonstrate the power of this test for a class of f(R) gravity, with the form f(R) = {lambda}{sub 1}H{sub 0}{sup 2} exp(-R/{lambda}{sub 2}H{sub 0}{sup 2}). Such f(R) gravity, even with degenerate expansion history to {Lambda}CDM, can produce detectable ISW effect at z {approx}> 3 and l {approx}> 20. Null-detection of such effect would constrain {lambda}{sub 2} to be {lambda}{sub 2} > 1000 at > 95% confidence level. On the other hand, robust detection of ISW-LSS cross correlation at high z will severely challenge general relativity.

  16. High energy behaviour of form factors

    NASA Astrophysics Data System (ADS)

    Ahmed, Taushif; Henn, Johannes M.; Steinhauser, Matthias

    2017-06-01

    We solve renormalization group equations that govern infrared divergences of massless and massive form factors. By comparing to recent results for planar massive three-loop and massless four-loop form factors in QCD, we give predictions for the high-energy limit of massive form factors at the four- and for the massless form factor at five-loop order. Furthermore, we discuss the relation which connects infrared divergences regularized dimensionally and via a small quark mass and extend results present in the literature to higher order.

  17. Late-onset Tay-Sachs disease.

    PubMed

    Barritt, Andrew W; Anderson, Stuart J; Leigh, P Nigel; Ridha, Basil H

    2017-10-01

    We discuss the assessment and differential diagnoses of a young adult Hungarian man with a 1-year history of a progressive and symmetric amyotrophic lateral sclerosis-like syndrome, along with irregular action tremor and stimulus-sensitive myoclonus of the arms. MR scan of the brain showed isolated cerebellar atrophy and formal neuropsychometric testing identified significant subclinical deficits in attention, processing speed and memory. We suspected a form of GM2 gangliosidosis, and white cell enzyme analysis showed markedly reduced enzymatic activity of β-hexosaminidase A. Genetic testing subsequently revealed two heterozygous pathogenic mutations in the HEXA gene (c.1499delT p.(Leu500fs) and c.805G>A p.(Gly269Ser)), confirming the very rare diagnosis of adult-onset Tay-Sachs disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. Ethical Issues with Genetic Testing for Tay-Sachs.

    PubMed

    Clayton, Tricia

    Several genetic disorders are specific to Jewish heritage; one of the most devastating is Tay-Sachs disease.Tay-Sachs is a fatal hereditary disease, causing progressive neurological problems for which there is no cure. Ethical issues surrounding genetic testing for Tay-Sachs within the Jewish community continue to be complex and multifaceted. A perspective of Tay-Sachs, using rights-based ethics and virtue ethics as a theoretical framework, is explored.

  19. [Tay-Sachs disease in non-Jewish infant in Israel].

    PubMed

    Nadim, Nasser

    2012-01-01

    Tay-Sachs disease, also known as GM2 gangliosidosis or Hexosaminidase A deficiency is an autosomal recessive genetic fatal disorder. The disease is known to appear in East European Ashkenazi Jews, North African Jews, and Quebec French Canadians exclusively, but, with different frequency and type of mutation. Its most common variant is the infantile type Tay-Sachs disease. Juvenile and late-onset forms of the disease are infrequent and slowly progressive. At nearly 3 to 6 months old, a baby with Tay-Sachs progressively loses his motor skills and attentiveness. Startle responses and hyperreflexia become prominent, especially on eliciting deep patellar and Achilles reflexes, as a consequence of neurodegeneration of the upper motor neuron. Other systemic damage ensues gradually; seizures, blindness, spasticity of limbs, inability to swallow and breathe, and eventually the baby dies at 1-4 years of age. All Tay-Sachs patients have a "cherry red spot", easily seen in the macula area of the retina, using an ophthalmoscope. The "cherry red spot" is the only normal part of the retina in these sick babies. The case presented here emphasizes that Tay-Sachs disease is sometimes misdiagnosed at first visits even by an experienced clinician, because of his lack of awareness that this disease is not exclusively a Jewish disease.

  20. Jet acollinearity and quark form factors

    SciTech Connect

    Stirling, W.J.

    1980-01-01

    Perturbative Quantum Chromodynamic corrections involving the emission of gluons which are both soft and collinear are discussed for both hadronic production of lepton pairs and e/sup +/e/sup -/ annihilation. The result is an exponential, double logarithmic quark form factor. The effect of sub-leading corrections and the possible experimental observation of the form factor are discussed.

  1. Form factors in the radiative pion decay

    NASA Astrophysics Data System (ADS)

    Mateu, V.; Portolés, J.

    2007-10-01

    We perform an analysis of the form factors that rule the structure-dependent amplitude in radiative pion decay. The resonance contributions to π→eνeγ decays are computed through the proper construction of the vector and axial-vector form factors by setting the QCD driven asymptotic properties of the three-point Green functions and , and by demanding the smoothening of the form factors at high transfer of momentum. A comparison between theoretical and experimental determination of the form factors is also carried out. We also consider and evaluate the role played by a non-standard tensor form factor. We conclude that, at present and due to the hadronic uncertainties, the search for new physics in this process is not feasible.

  2. Kantowski-Sachs cosmological solutions in the generalized teleparallel gravity via Noether symmetry

    NASA Astrophysics Data System (ADS)

    Motavalli, H.; Akbarieh, A. Rezaei; Nasiry, M.

    2016-04-01

    We study the f(T) theory as an extension of teleparallel gravity and consider the Noether symmetry of Kantowski-Sachs (KS) anisotropic model for this theory. We specify the explicit teleparallel form of f(T) and find the corresponding exact cosmological solutions under the assumption that the Lagrangian admits the Noether symmetry. It is found that the universe experiences a power law expansion for the scale factors in the context of f(T) theory. By deriving equation of state (EOS) parameter, we show that the universe passes through the phantom and ΛCDM theoretical scenarios. In this way, we estimate a lower limit age for the universe in excellent agreement with the value reported from recent observations. When KS model reduces to the flat Friedmann-Robertson-Walker (FRW) metric, our results are properly transformed into the corresponding values.

  3. Burg-Metzner-Sachs symmetry, string theory, and soft theorems

    NASA Astrophysics Data System (ADS)

    Avery, Steven G.; Schwab, Burkhard U. W.

    2016-01-01

    We study the action of the Burg-Metzner-Sachs (BMS) group in critical, bosonic string theory living on a target space of the form Md×C . Here Md is d -dimensional (asymptotically) flat spacetime and C is an arbitrary compactification. We provide a treatment of generalized Ward-Takahashi identities and derive consistent boundary conditions for any d from string theory considerations. Finally, we derive BMS transformations in higher-dimensional spacetimes and show that the generalized Ward-Takahashi identity of BMS produces Weinberg's soft theorem in string theory.

  4. [beta]-hexosaminidase isozymes from cells cotransfected with [alpha] and [beta] cDNA constructs: Analysis of the [alpha]-subunit missense mutation associated with the adult form of Tay-Sachs disease

    SciTech Connect

    Brown, C.A.; Mahuran, D.J. )

    1993-08-01

    In vitro mutagenesis and transient expression in COS cells has been used to associate a missense mutation with a clinical or biochemical phenotype. Mutations affecting the [alpha]-subunit of [beta]-hexosaminidase A ([alpha][beta]) (E.C.3.2.1.52) result in Tay-Sachs disease. Because hexosaminidase A is heterodimeric, analysis of [alpha]-chain mutations is not straightforward. The authors examine three approaches utilizing previously identified mutations affecting [alpha]-chain folding. These involve transfection of (1) the [alpha] cDNA alone; (2) a [beta] cDNA construct encoding a [beta]-subunit substituted at a position homologous to that of the [alpha]-subunit, and (3) both [alpha] and [beta] cDNAs. The latter two procedures amplified residual activity levels over that of patient samples, an effect not previously found with mutations affecting an [open quotes]active[close quotes] [alpha]Arg residue. This effect may help to discriminate between protein-folding and active-site mutations. The authors conclude that, with proper controls, the latter method of cotransfection can be used to evaluate the effects and perhaps to predict the clinical course of some [alpha]-chain mutations. Using this technique, they demonstrate that the adult-onset Tay-Sachs mutation, [alpha]Gly[yields]Ser[sup 269], does not directly affect [alpha][beta] dimerization but exerts an indirect effect on the dimer through destabilizing the folded [alpha]-subunit at physiological temperatures. Two other [alpha] mutations linked to more severe phenotypes appear to inhibit the initial folding of the subunit. 36 refs., 2 figs., 5 tabs.

  5. Electromagnetic nucleon form factors in instant and point form

    SciTech Connect

    Melde, T.; Berger, K.; Plessas, W.; Wagenbrunn, R. F.; Canton, L.

    2007-10-01

    We present a study of the electromagnetic structure of the nucleons with constituent quark models in the framework of relativistic quantum mechanics. In particular, we address the construction of spectator-model currents in the instant and point forms. Corresponding results for the elastic nucleon electromagnetic form factors as well as charge radii and magnetic moments are presented. We also compare results obtained by different realistic nucleon wave functions stemming from alternative constituent quark models. Finally, we discuss the theoretical uncertainties that reside in the construction of spectator-model transition operators.

  6. Measurements of baryon form factors at BESIII

    NASA Astrophysics Data System (ADS)

    Li, Cui

    2016-08-01

    The momentum transfer dependence of the electromagnetic form factors is an important probe of the structure of hadrons at different scales. Using data samples collected with the BESIII detector at the BEPCII collider, we study the process of e+e- → pp¯ at 12 c.m. energies from 2232.4 to 3671.0 MeV. The Born cross section at these energy points are measured as well as the corresponding effective electromagnetic form factors. Furthermore, the ratio of electric to magnetic form factors, |GE/GM | and |GM | are measured at the c.m. energies where the data samples are the largest. We also report preliminary results of e+e- → ˄˄̅, which is analysed with the same method. Moreover, future prospects of the measurement of baryon electromagnetic form factors from a unique high luminosity data scan by BESIII, are given.

  7. Strangeness contributions to nucleon form factors

    SciTech Connect

    Ross Young

    2006-09-11

    We review a recent theoretical determination of the strange quark content of the electromagnetic form factors of the nucleon. These are compared with a global analysis of current experimental measurements in parity-violating electron scattering.

  8. Engaging Hill-Sachs Defects

    PubMed Central

    Burns, David; Chahal, Jaskarndip; Shahrokhi, Shahram; Henry, Patrick; Wasserstein, David; Whyne, Cari; Theodoropoulos, John S.; Ogilvie-Harris, Darrell; Dwyer, Tim

    2016-01-01

    Objectives: Anatomic studies have demonstrated that bipolar glenoid and humeral bone loss have a cumulative impact on shoulder instability, and that these defects may engage in functional positions depending on their size, location, and orientation, potentially resulting in failure of stabilization procedures. Determining which lesions pose a risk for engagement remains a challenge, with arthroscopic assessment and Itoi’s 3DCT based glenoid track method being the accepted approaches at this time. The purpose of this study was to investigate the interaction of humeral and glenoid bone defects on shoulder engagement in a cadaveric model. Two alternative approaches to predicting engagement were evaluated; 1) CT scanning the shoulder in abduction and external rotation 2) measurement of Bankart lesion width and a novel parameter, the intact anterior articular angle (IAAA), on conventional 2D multi-plane reformats. The results of these two approaches were compared to the results obtained using Itoi’s glenoid track method for predicting engagement. Methods: Hill-Sachs and Bony Bankart defects of varying size were created in 12 cadaveric upper limbs, producing 45 bipolar defect combinations. The shoulders were assessed for engagement using cone beam CT in various positions of function, from 30 to 90 degrees of both abduction and external rotation. The humeral and glenoid defects were characterized by measurement of their size, location, and orientation. Diagnostic performance measures for predicting engagement were calculated for both the abduction external rotation scan and 2D IAAA approaches using the glenoid track method as reference standard. Results: Engagement was predicted by Itoi’s glenoid track method in 24 of 45 specimens (53%). The abduction external rotation CT scan performed at 60 degrees of glenohumeral abduction (corresponding to 90 degrees of abduction relative to the trunk) and 90 degrees of external rotation predicted engagement accurately in 43 of

  9. George Wilbur: Otto Rank and Hanns Sachs.

    PubMed

    Roazen, Paul

    2006-01-01

    George Wilbur, a pioneering Cape Cod psychoanalytic psychiatrist, was a long-standing editor of the journal "American Imago," and an excellent source of information about the Viennese analysts Otto Rank and Hanns Sachs. Wilbur was also knowledgeable about the early reception of psychoanalysis in the Boston community.

  10. Rapid identification of HEXA mutations in Tay-Sachs patients.

    PubMed

    Giraud, Carole; Dussau, Jeanne; Azouguene, Emilie; Feillet, François; Puech, Jean-Philippe; Caillaud, Catherine

    2010-02-19

    Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder due to mutations in the HEXA gene resulting in a beta-hexosaminidase A (Hex A) deficiency. The purpose of this study was to characterize the molecular abnormalities in patients with infantile or later-onset forms of the disease. The complete sequencing of the 14 exons and flanking regions of the HEXA gene was performed with a unique technical condition in 10 unrelated TSD patients. Eleven mutations were identified, including five splice mutations, one insertion, two deletions and three single-base substitutions. Four mutations were novel: two splice mutations (IVS8+5G>A, IVS2+4delAGTA), one missense mutation in exon 6 (c.621T>G (p.D207E)) and one small deletion (c.1211-1212delTG) in exon 11 resulting in a premature stop codon at residue 429. The c.621T>G missense mutation was found in a patient presenting an infantile form. Its putative role in the pathogenesis of TSD is suspected as residue 207 is highly conserved in human, mouse and rat. Moreover, structural modelling predicted changes likely to affect substrate binding and catalytic activity of the enzyme. The time-saving procedure reported here could be useful for the characterization of Tay-Sachs-causing mutations, in particular in non-Ashkenazi patients mainly exhibiting rare mutations.

  11. Magnetic form factors of the trinucleons

    SciTech Connect

    Schiavilla, R; Pandharipande, V R; Riska, Dan-Olof

    1989-11-01

    The magnetic form factors of 3H and 3He are calculated with the Monte Carlo method from variational ground-state wave functions obtained for the Argonne and Urbana two- and three-nucleon interactions. The electromagnetic current operator contains one- and two-body terms that are constructed so as to satisfy the continuity equation with the two-nucleon potential in the Hamiltonian. The results obtained with the Argonne two-nucleon interaction are in overall agreement with the empirical values. It appears that the remaining theoretical uncertainty, in the calculation of these form factors from a given interaction model, is dominated by that in the electromagnetic form factors of the nucleon. It is found that the isovector magnetic form factors are rather sensitive to the details of the isospin-dependent tensor force, and they are much better reproduced with the Argonne than the Urbana potential. The isoscalar magnetic form factors appear to be sensitive to the spin-orbit interactions, and are better reproduced with the Urbana potential. The Argonne potential has a stronger τ1∙τ2 tensor force, while the Urbana one has a shorter-range spin-orbit interaction.

  12. Charm form factors in hadronic interactions

    SciTech Connect

    Bracco, M. E.; Navarra, F. S.; Nielsen, M.; Chiapparini, M.

    2010-12-28

    We calculate the form factors and the coupling constants in vertices with charm mesons, such as {rho}D*D*, in the framework of QCD sum rules. We first discuss the applications of these form factors in heavy ion collisions and in B decays. We then present an introduction to the method of QCD sum rules and describe how to work with the three-point function. We give special attention to the procedure employed to extrapolate results obtained in the deep euclidean region to the poles of the particles, located in the time-like region. Finally we present a table of ready-to-use parametrizations of all the form factors, which are relevant for the processes mentioned in the introduction. We also give the coupling constants.

  13. The Form Factors of the Nucleons

    SciTech Connect

    Perdrisat, Charles F.

    2013-11-01

    There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has been greatly improved by performing double-polarization experiments, in comparison with with pre-vious unpolarized cross section data. Here we will review the experimental data base in view of the new results for the proton and the neutron, obtained at MIT-Bates, JLab and MAMI. The rapid evolution of phenomenological models triggered by these high- precision experiments will be discussed. In particular, the possibility that the proton is non-spherical in its ground state, and that the transverse charge density are model in- dependently defined in the infinite momentum frame. Likewise, flavor decomposition of the nucleon form factors into dressed u and d quark form factors, may give information about the quark-diquark structure of the nucleon. The current proton radius "crisis" will also be discussed.

  14. Study of Baryon Form Factor at BESIII

    NASA Astrophysics Data System (ADS)

    Zhang, Bingxin

    Using data samples collected with BESIII detector at BEPCII collider, we measure Born cross section of e+e- → pbar{p} at center of mass energies √{s} from 2232.4 to 3671.0 MeV. The effective electromagnetic form factor of the proton is deduced with assumption that electric and magnetic form factors are equal GE = GM . For e+e- → Λ bar{Λ }, the Born cross sections and effective form factors are measured at √{s} = 2.2324, 2.40, 2.80, and 3.08 GeV. It is the first time that e+e- → Λ bar{Λ } process is studied closed to Λ bar{Λ } production threshold, and measured cross section is much larger than phase space expectations, which suggests that something more is at play beyond expected phase space behavior.

  15. The form factors of the nucleons

    NASA Astrophysics Data System (ADS)

    Perdrisat, C. F.

    2013-11-01

    There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has been greatly improved by performing double-polarization experiments, in comparison with with previous unpolarized cross section data. Here we will review the experimental data base in view of the new results for the proton and the neutron, obtained at MIT-Bates, JLab and MAMI. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed. In particular, the possibility that the proton is non-spherical in its ground state, and that the transverse charge density are model independently defined in the infinite momentum frame. Likewise, flavor decomposition of the nucleon form factors into dressed u and d quark form factors, may give information about the quark-diquark structure of the nucleon. The current proton radius "crisis" will also be discussed.

  16. The form factors of the nucleons

    SciTech Connect

    Petratos, G.G.

    1993-12-01

    The study of the electromagnetic form factors of the nucleons are of fundamental importance in understanding nucleon structure. The form factors contain all the information about the deviation from pointlike structure of the charge and magnetization current distributions of the nucleons. The hope is that measurements at sufficiently large momentum transfers can provide a microscopic understanding of the nucleon wave functions in terms of their constituent quark amplitudes. Recent measurements of the electric G{sub E}(Q{sup 2}) and magnetic G{sub M}(Q{sup 2}) form factors of the nucleons are reviewed and compared to theoretical calculations based on non-perturbative QCD sum rules, diquark, relativistic constituent quark, and vector meson dominance (VMD) models. A short summary of ongoing and future measurements is also presented.

  17. Nucleon Form Factors - A Jefferson Lab Perspective

    SciTech Connect

    John Arrington, Kees de Jager, Charles F. Perdrisat

    2011-06-01

    The charge and magnetization distributions of the proton and neutron are encoded in their elastic electromagnetic form factors, which can be measured in elastic electron--nucleon scattering. By measuring the form factors, we probe the spatial distribution of the proton charge and magnetization, providing the most direct connection to the spatial distribution of quarks inside the proton. For decades, the form factors were probed through measurements of unpolarized elastic electron scattering, but by the 1980s, progress slowed dramatically due to the intrinsic limitations of the unpolarized measurements. Early measurements at several laboratories demonstrated the feasibility and power of measurements using polarization degrees of freedom to probe the spatial structure of the nucleon. A program of polarization measurements at Jefferson Lab led to a renaissance in the field of study, and significant new insight into the structure of matter.

  18. Hadronic form factors in kaon photoproduction

    SciTech Connect

    Syukurilla, L. Mart, T.

    2014-09-25

    We have revisited the effect of hadronic form factors in kaon photoproduction process by utilizing an isobaric model developed for kaon photoproduction off the proton. The model is able to reproduce the available experimental data nicely as well as to reveal the origin of the second peak in the total cross section, which was the main source of confusion for decades. Different from our previous study, in the present work we explore the possibility of using different hadronic form factors in each of the KΛN vertices. The use of different hadronic form factors, e.g. dipole, Gaussian, and generalized dipole, has been found to produce a more flexible isobar model, which can provide a significant improvement in the model.

  19. Form Factors and Radii of Light Nuclei

    SciTech Connect

    Sick, Ingo

    2015-09-15

    We discuss the determination of electromagnetic form factors from the world data on electron–nucleus scattering for nuclei Z ≤ 3, with particular emphasis on the derivation of the moments required for comparison with measurements from electronic/muonic atoms and isotope shifts.

  20. Electromagnetic charged and neutral kaon form factors

    SciTech Connect

    Roberts, C.D.; Burden, C.J.; Thomson, M.J.

    1995-08-01

    The electromagnetic form factor of the charged and neutral kaon is calculated using the approach applied in the successful study of the pion form factor, described above. The charged kaon form factor will be measured in forthcoming experiments at CEBAF. Our calculation involves the dressed strange quark propagator, to which F{sub {pi}}(q{sup 2}) is not sensitive, and hence it provides us with constraints on the strange-quark sector of QCD. Our preliminary results are encouraging. We find that the strange and up/down quark propagators are not too different, once the change in the current-quark-mass is accounted for. However, the difference that remains is important since it allows {l_angle}{bar s}s{r_angle}<{l_angle}{bar u}u{r_angle}. This calculation is the first to yield a value of f{sub K}/f{sub {pi}} that is in good agreement with experiment and also yields r{sub K+}/r{sub {pi}} in good agreement with experiment. Our calculated charged kaon form factor provides a prediction that will be tested in the forthcoming CEBAF experiments. Our studies also show that K{sup 0} has a negative charge radius, as is to be expected. Our calculated value will be compared with that measured in K{sub s}{sup 0} regeneration from electrons.

  1. Meson-photon transition form factors

    SciTech Connect

    Balakireva, Irina; Lucha, Wolfgang; Melikhov, Dmitri

    2012-10-23

    We present the results of our recent analysis of the meson-photon transition form factors F{sub P{gamma}}(Q{sup 2}) for the pseudoscalar mesons P {pi}{sup 0},{eta},{eta} Prime ,{eta}{sub c}, using the local-duality version of QCD sum rules.

  2. Nucleon and Deuteron Form Factors from BLAST

    SciTech Connect

    Hasell, D. K.

    2009-12-17

    The BLAST experiment was designed to study in a systematic manner the spin-dependent, electromagnetic interaction on hydrogen and deuterium. Measuring only asymmetries in electron scattering with respect to the beam helicity, target spin, or both; the BLAST experiment was able to extract information on nucleon and deuteron form factors independent of beam intensity or target density. By further forming 'super-ratios' of asymmetries, measurements were possible independent of beam and target polarization thus reducing uncertainties due to these quantities as well. Some of the form factor results from BLAST will be briefly presented here. Also, in response to observed discrepancies between polarization measurements and those obtained using traditional Rosenbluth separation techniques a proposed experiment, OLYMPUS, which will use the BLAST detector to measure the two photon contribution to elastic electron scattering will also be presented.

  3. [Tay-Sachs disease: a case report].

    PubMed

    Koch, S; Widhalm, K

    1991-01-01

    After an infection of the respiratory tract at the age of one a male infant showed progressive mental and physical retardation. Outstanding signs (e.g. baby doll face, startle reaction and frog position) as well as results of special investigations (cherry red spots of the maculae, short tubular bones) were suspicious for the presence of a lipidstorage disease, that could be identified as Tay-Sachs disease because of absent hexosaminidase A-activity in the patient's serum. Inspite the very low incidence of Tay-Sachs disease in our population, compared with a frequency of 1: 1200 in Ashkenzi Jews, the importance of establishing a diagnosis, based on typical clinical features and biochemical results, has to be emphasized. Genetic consultation is the only point of influence in positive family history, for attempts of causal therapy are not successful at present.

  4. Tay Sachs disease: an autopsy case report.

    PubMed

    Jadhav, Meenal Vitthal; Landge, Meenal P; Sawaimoon, Satyakam K; Harke, Arun B; Deshmukh, Sanjay D

    2005-10-01

    This report describes a case report of a postmortem performed on a 5-year old patient of Tay-Sachs disease, presenting with failure to thrive, muscular flaccidity, and cherry-red spots on macula on fundoscopy. There was no history of similarly affected sibling or any other family member. The diagnosis was confirmed by enzyme studies. At postmortem, there was no organomegaly. The brain, on microscopy, showed vacuolated swollen neurons.

  5. Relationship Between Glenoid Defects and Hill-Sachs Lesions in Shoulders With Traumatic Anterior Instability.

    PubMed

    Nakagawa, Shigeto; Ozaki, Ritsuro; Take, Yasuhiro; Iuchi, Ryo; Mae, Tatsuo

    2015-11-01

    While the combination of a glenoid defect and a Hill-Sachs lesion in a shoulder with anterior instability has recently been termed a bipolar lesion, their relationship is unclear. To investigate the relationship of the glenoid defect and Hill-Sachs lesion and the factors that influence the occurrence of these lesions as well as the recurrence of instability. Case-control study; Level of evidence, 3. The prevalence and size of both lesions were evaluated retrospectively by computed tomography scanning in 153 shoulders before arthroscopic Bankart repair. First, the relationship of lesion prevalence and size was investigated. Then, factors influencing the occurrence of bipolar lesions were assessed. Finally, the influence of these lesions on recurrence of instability was investigated in 103 shoulders followed for a minimum of 2 years. Bipolar lesions, isolated glenoid defects/isolated Hill-Sachs lesions, and no lesion were detected in 86, 45, and 22 shoulders (56.2%, 29.4%, and 14.4%), respectively. As the glenoid defect became larger, the Hill-Sachs lesion also increased in size. However, the size of these lesions showed a weak correlation, and large Hill-Sachs lesions did not always coexist with large glenoid defects. The prevalence of bipolar lesions was 33.3% in shoulders with primary instability and 61.8% in shoulders with recurrent instability. In relation to the total events of dislocations/subluxations, the prevalence was 44.2% in shoulders with 1 to 5 events, 69.0% in shoulders with 6 to 10 events, and 82.8% in shoulders with ≥11 events. Regarding the type of sport, the prevalence was 58.9% in athletes playing collision sports, 53.3% in athletes playing contact sports, and 29.4% in athletes playing overhead sports. Postoperative recurrence of instability was 0% in shoulders without lesions, 0% with isolated Hill-Sachs lesions, 8.3% with isolated glenoid defects, and 29.4% with bipolar lesions. The presence of a bipolar lesion significantly influenced the

  6. Form factors for Russian doll droplet models

    NASA Astrophysics Data System (ADS)

    Wilemski, G.; Obeidat, A.; Hrahsheh, F.

    2013-05-01

    Molecular dynamics (MD) simulations of nanodroplets containing water and nonane show them to be nonspherical and strongly phase separated. A simple, but realistic model for these "Russian doll" structures is a spherical nonane lens that partially wets a spherical water droplet. This document contains an analytical calculation of the particle form factor P(q) needed to analyze experimental measurements of small angle neutron and x-ray scattering from aerosols of particles with this type of structure. In addition, an exact formulation of the particle form factor is developed for cylindrically symmetric droplets with otherwise arbitrary scattering length density functions. This result will be useful to calculate P(q) directly from MD simulation results. We compare results using both formulations and find excellent agreement between them.

  7. Baryon transition form factors at the pole

    SciTech Connect

    Tiator, L.; Döring, M.; Workman, R. L.; Hadžimehmedović, M.; Osmanović, H.; Omerović, R.; Stahov, J.; Švarc, A.

    2016-12-01

    Electromagnetic resonance properties are uniquely defined at the pole and do not depend on the separation of the resonance from background or the decay channel. Photon-nucleon branching ratios are nowadays often quoted at the pole, and we generalize the considerations to the case of virtual photons. We derive and compare relations for nucleon to baryon transition form factors both for the Breit-Wigner and the pole positions. Using the MAID2007 and SAID SM08 partial wave analyses of pion electroproduction data, we compare the $G_M$, $G_E$, and $G_C$ form factors for the $\\Delta(1232)$ resonance excitation at the Breit-Wigner resonance and pole positions up to $Q^2=5$ GeV$^2$. We also explore the $E/M$ and $S/M$ ratios as functions of $Q^2$. For pole and residue extraction, we apply the Laurent + Pietarinen method.

  8. Baryon transition form factors at the pole

    NASA Astrophysics Data System (ADS)

    Tiator, L.; Döring, M.; Workman, R. L.; Hadžimehmedović, M.; Osmanović, H.; Omerović, R.; Stahov, J.; Švarc, A.

    2016-12-01

    Electromagnetic resonance properties are uniquely defined at the pole and do not depend on the separation of the resonance from background or the decay channel. Photon-nucleon branching ratios are nowadays often quoted at the pole, and we generalize the considerations to the case of virtual photons. We derive and compare relations for nucleon to baryon transition form factors both for the Breit-Wigner and the pole positions. Using the MAID2007 and SAID SM08 partial wave analyses of pion electroproduction data, we compare the GM, GE, and GC form factors for the Δ (1232 ) resonance excitation at the Breit-Wigner resonance and pole positions up to Q2=5 GeV2 . We also explore the E /M and S /M ratios as functions of Q2. For pole and residue extraction, we apply the Laurent + Pietarinen method.

  9. A new approach for Delta form factors

    SciTech Connect

    C. Aubin, K. Orginos

    2011-10-01

    We discuss a new approach to reducing excited state contributions from two- and three-point correlation functions in lattice simulations. For the purposes of this talk, we focus on the Delta(1232) resonance and discuss how this new method reduces excited state contamination from two-point functions and mention how this will be applied to three-point functions to extract hadronic form factors.

  10. Elastic form factors at higher CEBAF energies

    SciTech Connect

    Petratos, G.G.

    1994-04-01

    The prospects for elastic scattering from few body systems with higher beam energies at CEBAF is presented. The deuteron and{sup 3}He elastic structure functions A(Q{sup 2}) can be measured at sufficiently high momentum transfers to study the transition between the conventional meson-nucleon and the constituent quark-gluon descriptions. Possible improvements in the proton magnetic form factor data are also presented.

  11. Heavy to light baryon transition form factors

    SciTech Connect

    Guo, X. |; Huang, T. |; Li, Z.

    1996-05-01

    Recently, Stech found form factor relations for heavy to light transitions based on two simple dynamical assumptions for a spectator particle. In this paper we generalize his approach to the case of baryons and find that for {Lambda}{sub {ital Q}}{r_arrow}{Lambda} ({ital Q}={ital b} or {ital c}) only one independent form factor remains in the limit {ital m}{sub {ital Q}}{r_arrow}{infinity}. Furthermore, combining with the model of Guo and Kroll we determine both of the two form factors for {Lambda}{sub {ital Q}}{r_arrow}{Lambda} in the heavy quark limit. The results are applied to {Lambda}{sub {ital b}}{r_arrow}{Lambda}+{ital J}/{psi} which is not clarified both theoretically and experimentally. It is found that the branching ratio of {Lambda}{sub {ital b}}{r_arrow}{Lambda}+{ital J}/{psi} is of order 10{sup {minus}5}. {copyright} {ital 1996 The American Physical Society.}

  12. Noether symmetries of Bianchi I, Bianchi III, and Kantowski-Sachs spacetimes in scalar-coupled gravity theories

    SciTech Connect

    Camci, Ugur; Kucukakca, Yusuf

    2007-10-15

    We consider some scalar-coupled theories of gravity, including induced gravity, and study the Noether symmetries of Bianchi I, Bianchi III, and Kantowski-Sachs cosmological models for this theory. For various forms of coupling of the scalar field with gravity, some potentials are found in these cosmological models under the assumption that the Lagrangian admits Noether symmetry. The solutions of the field equations for the considered models are presented by using the results obtained from the Noether symmetry. We also find the explicit form of the scalar field in terms of the conformal time for Bianchi I, III, and Kantowski-Sachs models.

  13. NN′-Diacetylchitobiase activity in Tay–Sachs disease and Sandhoff's disease (Short Communication)

    PubMed Central

    Stirling, John L.

    1974-01-01

    In Tay–Sachs disease and Sandhoff's disease respectively, one of the N-acetyl-β-hexosaminidases (form A) or both (forms A and B) are absent, but glycosaminoglycans containing N-acetylhexosamines are not accumulated. The presence of NN′-diacetylchitobiase in livers from patients with these diseases raises the possibility that this new enzyme is involved in the metabolism of glycosaminoglycans rather than the enzymes previously described. PMID:4455225

  14. The National Tay Sachs and Allied Diseases Association.

    ERIC Educational Resources Information Center

    Zeitlin, Paula

    1986-01-01

    The National Tay-Sachs and Allied Diseases Association is involved in education, research, and prevention of Tay-Sachs, an inherited metabolic disorder which destroys the central nervous system, and over 30 related disorders. The group features a parent peer group network and a support group for carrier couples. (CL)

  15. National Tay-Sachs and Allied Diseases Association, Inc.

    ERIC Educational Resources Information Center

    Exceptional Parent, 1977

    1977-01-01

    Reviewed are the history and organization, purpose and programs, and public services of the National Tay-Sachs and Allied Diseases Association, an organization geared toward eradicating Tay-Sachs disease (a hereditary disorder affecting primarily Jewish infants which generally leads to deterioration and death by the child's fifth year). (SBH)

  16. National Tay-Sachs and Allied Diseases Association, Inc.

    ERIC Educational Resources Information Center

    Exceptional Parent, 1977

    1977-01-01

    Reviewed are the history and organization, purpose and programs, and public services of the National Tay-Sachs and Allied Diseases Association, an organization geared toward eradicating Tay-Sachs disease (a hereditary disorder affecting primarily Jewish infants which generally leads to deterioration and death by the child's fifth year). (SBH)

  17. The National Tay Sachs and Allied Diseases Association.

    ERIC Educational Resources Information Center

    Zeitlin, Paula

    1986-01-01

    The National Tay-Sachs and Allied Diseases Association is involved in education, research, and prevention of Tay-Sachs, an inherited metabolic disorder which destroys the central nervous system, and over 30 related disorders. The group features a parent peer group network and a support group for carrier couples. (CL)

  18. Axillary shoulder with exaggerated rotation: the Hill-Sachs defect.

    PubMed

    Rafert, J A; Long, B W; Hernandez, E M; Kreipke, D L

    1990-01-01

    One of the most common fractures of the humeral head resulting from an anterior dislocation is the Hill-Sachs defect. Other special radiographic positions to demonstrate this injury may prove difficult for the patient to assume and maintain. An axillary shoulder projection with exaggerated external rotation is easy to position and clearly demonstrates the Hill-Sachs defect.

  19. Lattice Calculations of Nucleon Form Factors

    SciTech Connect

    Syritsyn, S. N.

    2011-10-24

    We present recent results of calculation of the isovector electromagnetic and axial form factors of the nucleon using lattice QCD with three different lattice actions and pion masses down to m{sub {pi}} > or approx. 300 MeV. Because of the precision of our high-statistics calculations, we can test predictions of baryon chiral perturbation theory for the charge and axial radii of the nucleon. We find that currently available baryon ChPT calculations disagree with our data, indicating that the corresponding effective theory approximations are not valid above m{sub {pi}{approx_equal}3}00 MeV.

  20. Neutron electric form factor via recoil polarimetry

    SciTech Connect

    Madey, Richard; Semenov, Andrei; Taylor, Simon; Aghalaryan, Aram; Crouse, Erick; MacLachlan, Glen; Plaster, Bradley; Tajima, Shigeyuki; Tireman, William; Yan, Chenyu; Ahmidouch, Abdellah; Anderson, Brian; Asaturyan, Razmik; Baker, O; Baldwin, Alan; Breuer, Herbert; Carlini, Roger; Christy, Michael; Churchwell, Steve; Cole, Leon; Danagoulian, Samuel; Day, Donal; Elaasar, Mostafa; Ent, Rolf; Farkhondeh, Manouchehr; Fenker, Howard; Finn, John; Gan, Liping; Garrow, Kenneth; Gueye, Paul; Howell, Calvin; Hu, Bitao; Jones, Mark; Kelly, James; Keppel, Cynthia; Khandaker, Mahbubul; Kim, Wooyoung; Kowalski, Stanley; Lung, Allison; Mack, David; Manley, D; Markowitz, Pete; Mitchell, Joseph; Mkrtchyan, Hamlet; Opper, Allena; Perdrisat, Charles; Punjabi, Vina; Raue, Brian; Reichelt, Tilmann; Reinhold, Joerg; Roche, Julie; Sato, Yoshinori; Seo, Wonick; Simicevic, Neven; Smith, Gregory; Stepanyan, Samuel; Tadevosyan, Vardan; Tang, Liguang; Ulmer, Paul; Vulcan, William; Watson, John; Wells, Steven; Wesselmann, Frank; Wood, Stephen; Yan, Chen; Yang, Seunghoon; Yuan, Lulin; Zhang, Wei-Ming; Zhu, Hong Guo; Zhu, Xiaofeng

    2003-05-01

    The ratio of the electric to the magnetic form factor of the neutron, G_En/G_Mn, was measured via recoil polarimetry from the quasielastic d({pol-e},e'{pol-n)p reaction at three values of Q^2 [viz., 0.45, 1.15 and 1.47 (GeV/c)^2] in Hall C of the Thomas Jefferson National Accelerator Facility. Preliminary data indicate that G_En follows the Galster parameterization up to Q^2 = 1.15 (GeV/c)^2 and appears to rise above the Galster parameterization at Q^2 = 1.47 (GeV/c)^2.

  1. Recent Studies of Nucleon Electromagnetic Form Factors

    NASA Astrophysics Data System (ADS)

    Gilad, Shalev

    2010-08-01

    The electromagnetic form factors of nucleons are fundamental quantities in nucleon structure. As such, they have been studied extensively both theoretically and experimentally. Significant progress has been made with new measurements at Jlab, MAMI and MIT-Bates, with emphases on expanding the momentum-transfer range and on higher precision. In this paper, we describe the status of this field and present new results from measurements at both low and high momentum transfers. We also compare the experimental data to model predictions, and mention possible implications of the new results to other fields.

  2. Transverse electromagnetic form factor in 12C

    NASA Astrophysics Data System (ADS)

    Cha, D.

    1980-04-01

    We calculate the contribution from the convection current to the recently measured transverse form factor of the 12C 2+ level at 4.44 MeV. The convection current dominates for small momentum transfer and is determined by the B(E 2). In this region, theory agrees with experiment. At intermediate momentum transfer, agreement with experiment is only possible assuming a coherent sum of the convection current and magnetization density contributions. NUCLEAR STRUCTURE 12C, E=4.44 MeV; calculated FT2.

  3. Survey of nucleon electromagnetic form factors

    SciTech Connect

    Perdrisat, Charles F.; Punjabi, Vina A.

    2011-09-20

    There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has been greatly improved by performing double polarization experiments, in compar- ison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at MIT-Bates, MAMI, and JLab. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed.

  4. Pion form factor from a contact interaction

    SciTech Connect

    Gutierrez-Guerrero, L. X.; Bashir, A.; Cloeet, I. C.; Roberts, C. D.

    2010-06-15

    In a Poincare-covariant vector-boson-exchange theory, the pion possesses components of pseudovector origin, which materially influence its observable properties. For a range of such quantities, we explore the consequences of a momentum-independent interaction, regularized in a symmetry-preserving manner. The contact interaction, while capable of describing pion static properties, produces a form factor whose evolution for Q{sup 2}>0.17 GeV{sup 2} disagrees markedly with experiment and whose asymptotic power-law behavior conflicts strongly with perturbative QCD.

  5. Integrated Sachs-Wolfe effect in massive bigravity

    NASA Astrophysics Data System (ADS)

    Enander, Jonas; Akrami, Yashar; Mörtsell, Edvard; Renneby, Malin; Solomon, Adam R.

    2015-04-01

    We study the integrated Sachs-Wolfe (ISW) effect in ghost-free, massive bigravity. We focus on the infinite-branch bigravity (IBB) model which exhibits viable cosmic expansion histories and stable linear perturbations, while the cosmological constant is set to zero and the late-time accelerated expansion of the Universe is due solely to the gravitational interaction terms. The ISW contribution to the CMB auto-correlation power spectrum is predicted, as well as the cross-correlation between the CMB temperature anisotropies and large-scale structure. We use ISW amplitudes as inferred from the WMAP 9-year temperature data together with galaxy and AGN data provided by the WISE mission in order to compare the theoretical predictions to the observations. The ISW amplitudes in IBB are found to be larger than the corresponding ones in the standard Λ CDM model by roughly a factor of 1.5, but are still consistent with the observations.

  6. TCP transcription factors: architectures of plant form.

    PubMed

    Manassero, Nora G Uberti; Viola, Ivana L; Welchen, Elina; Gonzalez, Daniel H

    2013-04-01

    After its initial definition in 1999, the TCP family of transcription factors has become the focus of a multiplicity of studies related with plant development at the cellular, organ, and tissue levels. Evidence has accumulated indicating that TCP transcription factors are the main regulators of plant form and architecture and constitute a tool through which evolution shapes plant diversity. The TCP transcription factors act in a multiplicity of pathways related with cell proliferation and hormone responses. In recent years, the molecular pathways of TCP protein action and biochemical studies on their mode of interaction with DNA have begun to shed light on their mechanism of action. However, the available information is fragmented and a unifying view of TCP protein action is lacking, as well as detailed structural studies of the TCP-DNA complex. Also important, the possible role of TCP proteins as integrators of plant developmental responses to the environment has deserved little attention. In this review, we summarize the current knowledge about the structure and functions of TCP transcription factors and analyze future perspectives for the study of the role of these proteins and their use to modify plant development.

  7. Electromagnetic Transition Form Factors of Nucleon Resonances

    SciTech Connect

    Burkert, Volker D.

    2008-10-13

    Recent measurements of nucleon resonance transition form factors with CLAS at Jefferson Lab are discussed. The new data resolve a long-standing puzzle of the nature of the Roper resonance, and confirm the assertion of the symmetric constituent quark model of the Roper as the first radial excitation of the nucleon. The data on high Q{sup 2} n{pi}{sup +} production confirm the slow fall off of the S{sub 11}(1535) transition form factor with Q{sup 2}, and better constrain the branching ratios {beta}{sub N{pi}} = 0.50 and {beta}{sub N{eta}} = 0.45. For the first time, the longitudinal transition amplitude to the S{sub 11}(1535) was extracted from the n{pi}{sup +} data. Also, new results on the transition amplitudes for the D{sub 13}(1520) resonance are presented showing a rapid transition from helicity 3/2 dominance seen at the real photon point to helicty 1/2 dominance at higher Q{sup 2}.

  8. Helium Compton Form Factor Measurements at CLAS

    SciTech Connect

    Voutier, Eric J.-M.

    2013-07-01

    The distribution of the parton content of nuclei, as encoded via the generalized parton distributions (GPDs), can be accessed via the deeply virtual Compton scattering (DVCS) process contributing to the cross section for leptoproduction of real photons. Similarly to the scattering of light by a material, DVCS provides information about the dynamics and the spatial structure of hadrons. The sensitivity of this process to the lepton beam polarization allows to single-out the DVCS amplitude in terms of Compton form factors that contain GPDs information. The beam spin asymmetry of the $^4$He($\\vec {\\mathrm e}$,e$' \\gamma ^4$He) process was measured in the experimental Hall B of the Jefferson Laboratory to extract the real and imaginary parts of the twist-2 Compton form factor of the $^4$He nucleus. The experimental results reported here demonstrate the relevance of this method for such a goal, and suggest the dominance of the Bethe-Heitler amplitude to the unpolarized process in the kinematic range explored by the experiment.

  9. Measurements of hadron form factors at BESIII

    NASA Astrophysics Data System (ADS)

    Morales, Cristina Morales

    2016-05-01

    BEPCII is a symmetric e+e--collider located in Beijing running at center-of-mass energies between 2.0 and 4.6 GeV. This energy range allows the BESIII-experiment to measure hadron form factors both from direct e+e--annihilation and from initial state radiation processes. In this paper, results on e+e- → p p ¯ based on data collected by BESIII in 2011 and 2012 are presented. We also present preliminary results on e+e- → Λ Λ ¯ based on the same data samples at 4 center-of-mass energies. BESIII results obtained from e+e- → π+π- using the initial state radiation technique at the center-of-mass energy of 3.773 GeV are also summarized. Finally, expectations on the measurement of baryon electromagnetic form factors from the BESIII high luminosity energy scan in 2015 and from initial state radiation processes at different center-of-mass energies are also explained.

  10. OLYMPUS and the proton form factor puzzle

    NASA Astrophysics Data System (ADS)

    Ice, Lauren; Alarcon, Ricardo; Olympus Collaboration

    2012-02-01

    Recent measurements of the proton electric to magnetic form factor ratio using polarization techniques reveal a large discrepancy with measurements found using the Rosenbluth separation technique. It has been proposed that this discrepancy is due to a non-negligible multiple photon exchange contribution in the electron-proton elastic scattering cross section. The OLYMPUS experiment will measure the multiple photon exchange contribution by finding the cross section ratio of positron-proton to electron-proton scattering within 1%. The experiment will be carried out at the DESY laboratory in Hamburg Germany using the electron and positron storage ring DORIS and an internal unpolarized hydrogen gas target. The scattered particles will be detected using the Bates Large Acceptance Spectrometer Toroid (BLAST).

  11. Physical Nucleon Form Factors from Lattice QCD

    SciTech Connect

    Hrayr Matevosyan; Anthony W. Thomas; Gerald A. Miller

    2005-10-25

    We explore the possibility of extrapolating state of the art lattice QCD calculations of nucleon form factors to the physical regime. We find that the lattice results can be reproduced using the Light Front Cloudy Bag Model and the Extended Gari-Krmpelmann Model by letting their parameters be analytic functions of the quark mass. We then use the models to extend the lattice calculations to large values of Q{sup 2} of interest to current and planned experiments. These functions for the first model are also used to define extrapolations to the physical value of the pion mass, thereby allowing us to study how the predicted zero in G{sub E}(Q{sup 2})/G{sub M}(Q{sup 2}) varies as a function of quark mass.

  12. Constant mean curvature slicings of Kantowski-Sachs spacetimes

    SciTech Connect

    Heinzle, J. Mark

    2011-04-15

    We investigate existence, uniqueness, and the asymptotic properties of constant mean curvature (CMC) slicings in vacuum Kantowski-Sachs spacetimes with positive cosmological constant. Since these spacetimes violate the strong energy condition, most of the general theorems on CMC slicings do not apply. Although there are in fact Kantowski-Sachs spacetimes with a unique CMC foliation or CMC time function, we prove that there also exist Kantowski-Sachs spacetimes with an arbitrary number of (families of) CMC slicings. The properties of these slicings are analyzed in some detail.

  13. Julius Sachs (1832–1897) and the Unity of Life

    PubMed Central

    Kutschera, Ulrich; Baluška, František

    2015-01-01

    In 1865, the German botanist Julius Sachs published a seminal monograph entitled Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) and hence became the founder of a new scientific discipline that originated 150 y ago. Here, we outline the significance of the achievements of Sachs. In addition, we document, with reference to his Vorlesungen über Pflanzen-Physiologie (Lectures on the Physiology of Plants, 1882), that Sachs was one of the first experimentalists who proposed the functional unity of all organisms alive today (humans, animals, plants and other “vegetable” organisms, such as algae, cyanophyceae, fungi, myxomycetes, and bacteria). PMID:26359706

  14. Julius Sachs (1832-1897) and the Unity of Life.

    PubMed

    Kutschera, Ulrich; Baluška, František

    2015-01-01

    In 1865, the German botanist Julius Sachs published a seminal monograph entitled Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) and hence became the founder of a new scientific discipline that originated 150 y ago. Here, we outline the significance of the achievements of Sachs. In addition, we document, with reference to his Vorlesungen über Pflanzen-Physiologie (Lectures on the Physiology of Plants, 1882), that Sachs was one of the first experimentalists who proposed the functional unity of all organisms alive today (humans, animals, plants and other "vegetable" organisms, such as algae, cyanophyceae, fungi, myxomycetes, and bacteria).

  15. Bondi-Sachs energy-momentum for the constant mean extrinsic curvature initial value problem

    NASA Astrophysics Data System (ADS)

    Bardeen, James M.; Buchman, Luisa T.

    2012-03-01

    The constraints on the asymptotic behavior of the conformal factor and conformal extrinsic curvature imposed by the initial value equations of general relativity on constant mean extrinsic curvature (CMC) hypersurfaces are analyzed in detail. We derive explicit formulas for the Bondi-Sachs energy and momentum in terms of coefficients of asymptotic expansions on CMC hypersurfaces near future null infinity. Precise numerical results for the Bondi-Sachs energy, momentum, and angular momentum are used to interpret physically Bowen-York initial data on conformally flat CMC hypersurfaces similar to that calculated earlier by Buchman et al. [L. T. Buchman, H. P. Pfeiffer, and J. M. Bardeen, Phys. Rev. DPRVDAQ1550-7998 80, 084024-1 (2009).10.1103/PhysRevD.80.084024].

  16. Vector and Axial Vector Pion Form Factors

    NASA Astrophysics Data System (ADS)

    Vitz, Michael; PEN Collaboration

    2015-04-01

    Radiative pion decay π+ -->e+ νγ (RPD) provides critical input to chiral perturbation theory (χPT). Aside from the uninteresting ``inner bremsstrahlung'' contribution from QED, the RPD rate contains ``structure dependent'' terms given by FV and FA, the vector and axial-vector pion form factors, respectively. The two appear in the decay rate in combinations FV -FA and FV +FA , i.e., in the so-called SD- and SD+ terms, respectively. The latter has been measured to high precision by the PIBETA collaboration. We report on the analysis of new data, measured by the PEN collaboration in runs between 2008 and 2010 at the Paul Scherrer Institute, Switzerland. We particularly focus on the possibility of improvement in the determination of the SD- term. Precise determinations of FV and FA test the validity of the CVC hypothesis, provide numerical input for the l9 +l10 terms in the χPT lagrangian, and constrain potential non-(V - A) terms, such as a possible tensor term FT. NSF grants PHY-0970013, 1307328, and others.

  17. The {Delta}(1232) resonance transition form factor

    SciTech Connect

    Staurt, L.M. |; Bosted, P.E.; Lung, A.

    1993-08-01

    Old and new measurements of inclusive e--p cross sections in the {Delta}(1232) resonance region have been combined, and a global data fit has been made. Using this fit to parameterize the nonresonant background, the transition form factors have been extracted out to a four-momentum transfer, Q{sup 2}, of 9.8 (GeV/c){sup 2}. The results are systematically higher than those from a previous analysis, but agree within errors. A similar analysis has been done with e--d cross sections, and {sigma}{sub n}/{sigma}{sub p} in the {Delta}(1232) resonance region has been extracted out to a Q{sup 2} of 7.9 (GeV/c){sup 2}. {sigma}{sub n}/{sigma}{sub p} for {Delta}(1232) production is consistent with unity, while {sigma}{sub n}/{sigma}{sub p} for the nonresonant background is constant with Q{sup 2} at approximately 0.4.

  18. Fragments of Science: Festschrift for Mendel Sachs

    NASA Astrophysics Data System (ADS)

    Ram, Michael

    1999-11-01

    The Table of Contents for the full book PDF is as follows: * Preface * Sketches at a Symposium * For Mendel Sachs * The Constancy of an Angular Point of View * Information-Theoretic Logic and Transformation-Theoretic Logic * The Invention of the Transistor and the Realization of the Hole * Mach's Principle, Newtonian Gravitation, Absolute Space, and Einstein * The Sun, Our Variable Star * The Inconstant Sun: Symbiosis of Time Variations of Sunspots, Atmospheric Radiocarbon, Aurorae, and Tree Ring Growth * Other Worlds * Super-Classical Quantum Mechanics * A Probabilistic Approach to the Phase Problem of X-Ray Crystallography * A Nonlinear Twist on Inertia Gives Unified Electroweak Gravitation * Neutrino Oscillations * On an Incompleteness in the General-Relativistic Description of Gravitation * All Truth is One * Ideas of Physics: Correspondence between Colleagues * The Influence of the Physics and Philosophy of Einstein's Relativity on My Attitudes in Science: An Autobiography

  19. Tay Sachs and Related Storage Diseases: Family Planning

    ERIC Educational Resources Information Center

    Schneiderman, Gerald; And Others

    1978-01-01

    Based on interviews with 24 families, the article discusses family planning and the choices available to those families in which a child has previously died from Tay-Sachs or related lipid storage diseases. (IM)

  20. Tay Sachs and Related Storage Diseases: Family Planning

    ERIC Educational Resources Information Center

    Schneiderman, Gerald; And Others

    1978-01-01

    Based on interviews with 24 families, the article discusses family planning and the choices available to those families in which a child has previously died from Tay-Sachs or related lipid storage diseases. (IM)

  1. Comparison of enzyme and DNA analysis in a Tay-Sachs disease carrier screening program.

    PubMed Central

    Yoo, H. W.; Astrin, K. H.; Desnick, R. J.

    1993-01-01

    Tay-Sachs disease (GM2 gangliosidosis, type 1; TSD) is an autosomal recessive GM2 gangliosidosis resulting from the deficient activity of the lysosomal hydrolase beta-hexosaminidase A (Hex A). With a carrier frequency estimated at 1 in 25, it is a common lysosomal disorder in the Ashkenazi Jewish population. Tay-Sachs disease has provided the prototype for the prevention of severe recessive genetic diseases. Molecular analysis of the Hex A gene (HEXA) of Ashkenazi Jewish individuals affected with Tay-Sachs disease revealed that three common mutations cause the infantile and adult onset forms of the disease; a four base insertion in exon 11, a splice junction mutation in intron 12 and a point mutation in exon 7 (G269S). A study was undertaken to determine whether mutation analysis would be useful in TSD screening programs in identifying carriers and clarifying the status of individuals whose enzyme assays are inconclusive. Ashkenazi Jewish individuals who had been diagnosed as carriers, inconclusives by enzyme assay and non-carriers with low normal enzyme levels in the Mount Sinai Tay-Sachs Disease Prevention Program were examined for the presence of the three mutations using polymerase chain reaction (PCR) and allele specific oligonucleotide (ASO) hybridization. The insertion mutation was present in 29 of 34 carriers and 2 of 36 inconclusive individuals, the splice junction mutation was found in 4 of 34 carriers and the G269S mutation was found in 1 of 34 carriers. Of the 313 non-carrier individuals with normal enzyme activity in the lower normal range, one was positive for the splice junction mutation.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8343225

  2. Nonlinear integrated Sachs-Wolfe effect

    NASA Astrophysics Data System (ADS)

    Cooray, Asantha

    2002-04-01

    We discuss the nonlinear extension to the integrated Sachs-Wolfe effect (ISW) resulting from the divergence of the large scale structure momentum density field. The nonlinear ISW effect leads to an increase in the total ISW contribution by roughly two orders of magnitude at l~1000. This increase, however, is still below the cosmic variance limit of the primary anisotropies; at further small angular scales, secondary effects such as gravitational lensing and the kinetic Sunyaev-Zel'dovich effect dominate the nonlinear ISW power spectrum. We show that this second-order nonlinear ISW contribution is effectively the same as the contribution previously described as a lensing effect due to the transverse motion of gravitational lenses and well known as the Kaiser-Stebbins effect in the context of cosmic strings. Because of geometrical considerations, there is no significant three-point correlation function, or bispectrum, between the linear ISW effect and its nonlinear extension. The nonlinear ISW contribution can potentially be used as a probe of the transverse velocity of dark matter halos such as galaxy clusters. Because of the small contribution to temperature fluctuations, of the order of a few tenths of microkelvins, however, extracting useful measurements on velocities will be challenging.

  3. Virtuality Distributions and Pion Transition Form Factor

    DOE PAGES

    Radyushkin, Anatoly V.

    2015-03-01

    Using the example of hard exclusive transition process γ*γ → π0 at the handbag level, we outline basics of a new approach to transverse momentum dependence in hard processes. In coordinate representation, matrix elements of operators (in the simplest case, bilocal O(0,z)) describing a hadron with momentum p, are functions of (pz) and z2 parametrized through virtuality distribution amplitudes (VDA) Φ(x, σ), with x being Fourier-conjugate to (pz) and σ Laplace-conjugate to z2. For intervals with z+=0, we introduce the transverse momentum distribution amplitude (TMDA) Ψ(x, k_perp), and write it in terms of VDA Φ(x,σ). We propose models for softmore » VDAs/TMDAs, and use them for comparison of handbag results with experimental (BaBar and BELLE) data. We also discuss the generation of hard tails of TMDAs from initially soft forms.« less

  4. Factor Structure of the Personality Research Form-E: A Maximum Likelihood Analysis.

    ERIC Educational Resources Information Center

    Fowler, Patrick C.

    1985-01-01

    Presents a five-factor, structural model of the Personality Research Form-E for 140 university undergraduates. All factors demonstrated an excellent level of similarity to those previously reported for other forms of the PRF, as well as to the conceptual scheme developed by Jackson (1974). (Author/JAC)

  5. Plant sulfur nutrition: From Sachs to Big Data.

    PubMed

    Kopriva, Stanislav

    2015-01-01

    Together with water and carbon dioxide plants require 14 essential mineral nutrients to finish their life cycle. The research in plant nutrition can be traced back to Julius Sachs, who was the first to experimentally prove the essentiality of mineral nutrients for plants. Among those elements Sachs showed to be essential is sulfur. Plant sulfur nutrition has been not as extensively studied as the nutrition of nitrogen and phosphate, probably because sulfur was not limiting for agriculture. However, with the reduction of atmospheric sulfur dioxide emissions sulfur deficiency has become common. The research in sulfur nutrition has changed over the years from using yeast and algae as experimental material to adopting Arabidopsis as the plant model as well as from simple biochemical measurements of individual parameters to system biology. Here the evolution of sulfur research from the times of Sachs to the current Big Data is outlined.

  6. Plant sulfur nutrition: From Sachs to Big Data

    PubMed Central

    Kopriva, Stanislav

    2015-01-01

    Together with water and carbon dioxide plants require 14 essential mineral nutrients to finish their life cycle. The research in plant nutrition can be traced back to Julius Sachs, who was the first to experimentally prove the essentiality of mineral nutrients for plants. Among those elements Sachs showed to be essential is sulfur. Plant sulfur nutrition has been not as extensively studied as the nutrition of nitrogen and phosphate, probably because sulfur was not limiting for agriculture. However, with the reduction of atmospheric sulfur dioxide emissions sulfur deficiency has become common. The research in sulfur nutrition has changed over the years from using yeast and algae as experimental material to adopting Arabidopsis as the plant model as well as from simple biochemical measurements of individual parameters to system biology. Here the evolution of sulfur research from the times of Sachs to the current Big Data is outlined. PMID:26305261

  7. A critique of Jeffrey D. Sachs's The end of poverty.

    PubMed

    Henwood, Doug

    2006-01-01

    Jeffrey Sachs's The End of Poverty is a manifesto and how-to guide on ending extreme poverty around the world; it promotes the U.N. Millennium Development Goals. Sachs achieved fame with his policy package for the "stabilization" of Bolivia (which did nothing to relieve Bolivia's poverty), and became advisor to the Yeltsin government in Russia and to Poland, Slovenia, and Estonia as they began their transitions to capitalism (the last three mixed successes; Russia a thorough disaster). Sachs later became more prominent as a critic of development orthodoxy, and was economic advisor to the Jubilee 2000 movement. The End of Poverty is full of sharp critiques of Western imperialism, but his views on the rest of the development business are more conventional.

  8. Progress in the Calculation of Nucleon Transition form Factors

    NASA Astrophysics Data System (ADS)

    Eichmann, Gernot

    2016-10-01

    We give a brief account of the Dyson-Schwinger and Faddeev-equation approach and its application to nucleon resonances and their transition form factors. We compare the three-body with the quark-diquark approach and present a quark-diquark calculation for the low-lying nucleon resonances including scalar, axialvector, pseudoscalar and vector diquarks. We also discuss the timelike structure of transition form factors and highlight the advantages of form factors over helicity amplitudes.

  9. The form factor of H-comb polymers

    NASA Astrophysics Data System (ADS)

    Zweier, Steven; Bishop, Marvin

    2009-12-01

    A Monte Carlo pivot algorithm is employed to investigate the form factor of continuum, tangent hard sphere H-comb polymers in both the ideal and excluded volume regimes. The simulated form factors for 241 and 931 "bead" ideal H-combs are essentially the same. The results for these polymers are in excellent agreement with the theoretical prediction. There is only a slight difference in the form factor between the ideal and excluded volume regimes at larger values of distance.

  10. Tay-Sachs disease in Jacob sheep.

    PubMed

    Torres, Paola A; Zeng, Bai Jin; Porter, Brian F; Alroy, Joseph; Horak, Fred; Horak, Joan; Kolodny, Edwin H

    2010-12-01

    Autopsy studies of four Jacob sheep dying within their first 6-8 months of a progressive neurodegenerative disorder suggested the presence of a neuronal storage disease. Lysosomal enzyme studies of brain and liver from an affected animal revealed diminished activity of hexosaminidase A (Hex A) measured with an artificial substrate specific for this component of β-hexosaminidase. Absence of Hex A activity was confirmed by cellulose acetate electrophoresis. Brain lipid analyses demonstrated the presence of increased concentrations of G(M2)-ganglioside and asialo-G(M2)-ganglioside. The hexa cDNA of Jacob sheep was cloned and sequenced revealing an identical number of nucleotides and exons as in human HexA and 86% homology in nucleotide sequence. A missense mutation was found in the hexa cDNA of the affected sheep caused by a single nucleotide change at the end of exon 11 resulting in skipping of exon 11. Transfection of normal sheep hexa cDNA into COS1 cells and human Hex A-deficient cells led to expression of Hex S but no increase in Hex A indicating absence of cross-species dimerization of sheep Hex α-subunit with human Hex β-subunits. Using restriction site analysis, the heterozygote frequency of this mutation in Jacob sheep was determined in three geographically separate flocks to average 14%. This large naturally occurring animal model of Tay-Sachs disease is the first to offer promise as a means for trials of gene therapy applicable to human infants.

  11. Analytical evaluation of atomic form factors: Application to Rayleigh scattering

    SciTech Connect

    Safari, L.; Santos, J. P.; Amaro, P.; Jänkälä, K.; Fratini, F.

    2015-05-15

    Atomic form factors are widely used for the characterization of targets and specimens, from crystallography to biology. By using recent mathematical results, here we derive an analytical expression for the atomic form factor within the independent particle model constructed from nonrelativistic screened hydrogenic wave functions. The range of validity of this analytical expression is checked by comparing the analytically obtained form factors with the ones obtained within the Hartee-Fock method. As an example, we apply our analytical expression for the atomic form factor to evaluate the differential cross section for Rayleigh scattering off neutral atoms.

  12. Analytical evaluation of atomic form factors: Application to Rayleigh scattering

    NASA Astrophysics Data System (ADS)

    Safari, L.; Santos, J. P.; Amaro, P.; Jänkälä, K.; Fratini, F.

    2015-05-01

    Atomic form factors are widely used for the characterization of targets and specimens, from crystallography to biology. By using recent mathematical results, here we derive an analytical expression for the atomic form factor within the independent particle model constructed from nonrelativistic screened hydrogenic wave functions. The range of validity of this analytical expression is checked by comparing the analytically obtained form factors with the ones obtained within the Hartee-Fock method. As an example, we apply our analytical expression for the atomic form factor to evaluate the differential cross section for Rayleigh scattering off neutral atoms.

  13. Temporary Efficacy of Pyrimethamine in Juvenile-Onset Tay-Sachs Disease Caused by 2 Unreported HEXA Mutations in the Indian Population

    PubMed Central

    Hajirnis, Omkar

    2017-01-01

    Background: Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. Patient: We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. Conclusion: This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects. PMID:28503624

  14. Temporary Efficacy of Pyrimethamine in Juvenile-Onset Tay-Sachs Disease Caused by 2 Unreported HEXA Mutations in the Indian Population.

    PubMed

    Udwadia-Hegde, Anaita; Hajirnis, Omkar

    2017-01-01

    Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.

  15. Tay-Sachs disease screening and prevention in South Africa.

    PubMed

    Jenkins, T; Lane, A B; Kromberg, J G

    1977-01-22

    Tay-Sachs disease is potentially preventable in Ashkenazi Jewish communities. About 1 out of 25 individuals is a carrier of the gene and can be accurately identified by means of a simple, inexpensive blood test. 'At risk' couples, i.e. couples of whom both partners are carriers, can be enabled, by means of prenatal diagnosis and selective abortion, to have only unaffected children. Mass screening programmes have been successfully carried out in the USA, Canada and Israel. A discussion of South African Jewish deomgraphy, attitudes to health, and priorities for public health projects, provide the background to a consideration of Tay-Sachs disease prevention in South Africa.

  16. X-Ray Form Factor, Attenuation and Scattering Tables

    National Institute of Standards and Technology Data Gateway

    SRD 66 X-Ray Form Factor, Attenuation and Scattering Tables (Web, free access)   This database collects tables and graphs of the form factors, the photoabsorption cross section, and the total attenuation coefficient for any element (Z <= 92).

  17. Nucleon Form Factors experiments with 12 GeV CEBAF

    SciTech Connect

    Wojtsekhowski, B.

    2008-10-13

    A number of precision form factor experiments at high momentum transfer will be performed with the 11 GeV electron beam of CEBAF. We review the approved proposals and the conceptual schemes of several new suggestions. Form factor data will serve as a major input for the construction of a tomographic image of the nucleon.

  18. Orthopositronium decay form factors and two-photon correlations

    SciTech Connect

    Adkins, Gregory S.; Droz, Daniel R.; Rastawicki, Dominik; Fell, Richard N.

    2010-04-15

    We give results for the orthopositronium decay form factors through one-loop order. We use the form factors to calculate momentum correlations of the final-state photons and , including one-loop corrections, for ensembles of initial orthopositronium atoms having arbitrary polarization.

  19. Relativistic quark model for the Omega- electromagnetic form factors

    SciTech Connect

    G. Ramalho, K. Tsushima, Franz Gross

    2009-08-01

    We compute the Omega- electromagnetic form factors and the decuplet baryon magnetic moments using a quark model application of the Covariant Spectator Theory. Our predictions for the Omega- electromagnetic form factors can be tested in the future by lattice QCD simulations at the physical strange quark mass.

  20. Relationship Domain of Form Six Teachers Thinking in Teaching with External Factors of Form Six Teachers

    ERIC Educational Resources Information Center

    bin Pet, Mokhtar; Sihes, Ahmad Johari Hj

    2015-01-01

    This study aims to examine the external factors of form six teachers who can influence thinking domain form six teachers in their teaching. This study was conducted using a quantitative approach using questionnaires. A total of 300 form six teacher schools in Johor were chosen as respondents. The findings were obtained as student background…

  1. Characterization of two Turkish beta-hexosaminidase mutations causing Tay-Sachs disease.

    PubMed

    Ozkara, Hatice Asuman; Sandhoff, Konrad

    2003-04-01

    Two homoallelic mutations have recently been identified in the alpha-subunit of hexosaminidase A (EC 3.2.1.52) causing the infantile form of Tay-Sachs disease in Turkish patients. Both of these mutations, a 12 bp deletion (1096-1107 or 1098-1108 or 1099-1109) in exon 10 and a point mutation (G1362 to A, Gly454 to Asp) in exon 12, are located in the catalytic domain of the hexosaminidase alpha-chain. In order to determine whether these mutations affect the function of the catalytic domain or result in an instable protein, both mutant cDNAs were overexpressed in COS-1 cells. As judged by Western blotting, transfections of wild-type cDNA produced pro-alpha-chain and mature alpha-chain in parallel with a fivefold increase in cellular hexosaminidase activity using the synthetic substrate 4-methylumbelliferyl beta-N-acetylglucosamine 6-sulfate (MUGS). However, both mutants produced only pro-alpha-chains, although no mature form or detectable hexosaminidase activity towards two different synthetic substrates was observed. These data are consistent with the biochemical phenotype of infantile Tay-Sachs disease. We conclude that the overexpressed mutant pro-alpha-chains were misfolded and could not undergo further proteolytic processing to the active form of the enzyme in the lysosome.

  2. Measuring the integrated Sachs-Wolfe effect

    NASA Astrophysics Data System (ADS)

    Dupé, F.-X.; Rassat, A.; Starck, J.-L.; Fadili, M. J.

    2011-10-01

    Context. One of the main challenges of modern cosmology is to understand the nature of the mysterious dark energy that causes the cosmic acceleration. The integrated Sachs-Wolfe (ISW) effect is sensitive to dark energy, and if detected in a universe where modified gravity and curvature are excluded, presents an independent signature of dark energy. The ISW effect occurs on large scales where cosmic variance is high and where owing to the Galactic confusion we lack large amounts of data in the CMB as well as large-scale structure maps. Moreover, existing methods in the literature often make strong assumptions about the statistics of the underlying fields or estimators. Together these effects can severely limit signal extraction. Aims: We aim to define an optimal statistical method for detecting the ISW effect that can handle large areas of missing data and minimise the number of underlying assumptions made about the data and estimators. Methods: We first review current detections (and non-detections) of the ISW effect, comparing statistical subtleties between existing methods, and identifying several limitations. We propose a novel method to detect and measure the ISW signal. This method assumes only that the primordial CMB field is Gaussian. It is based on a sparse inpainting method to reconstruct missing data and uses a bootstrap technique to avoid assumptions about the statistics of the estimator. It is a complete method, which uses three complementary statistical methods. Results: We apply our method to Euclid-like simulations and show we can expect a ~7σ model-independent detection of the ISW signal with WMAP7-like data, even when considering missing data. Other tests return ~5σ detection levels for a Euclid-like survey. We find that detection levels are independent from whether the galaxy field is normally or lognormally distributed. We apply our method to the 2 Micron All Sky Survey (2MASS) and WMAP7 CMB data and find detections in the 1.0-1.2σ range, as

  3. Rapid detection of fetal Mendelian disorders: Tay-Sachs disease.

    PubMed

    Guetta, Esther; Peleg, Leah

    2008-01-01

    Tay-Sachs disease is an autosomal recessive storage disease caused by the impaired activity of the lysosomal enzyme hexosaminidase A. In this fatal disease, the sphingolipid GM2 ganglioside accumulates in the neurons. Due to high carrier rates and the severity of the disease, population screening and prenatal diagnosis of Tay-Sachs disease are routinely carried out in Israel. Laboratory diagnosis of Tay-Sachs is carried out with biochemical and DNA-based methods in peripheral and umbilical cord blood, amniotic fluid, and chorionic villi samples. The assay of hexosaminidase A (Hex A) activity is carried out with synthetic substrates, 4-methylumbelliferyl-6-sulfo-N-acetyl-beta-glucosaminide (4-MUGS) and 4-methylumbelliferil-N-acetyl-beta-glucosamine (4-MUG), and the DNA-based analysis involves testing for the presence of specific known mutations in the alpha-subunit gene of Hex A. Prenatal diagnosis of Tay-Sachs disease is accomplished within 24-48 h from sampling. The preferred strategy is to simultaneously carry out enzymatic analysis in the amniotic fluid supernatant or in chorionic villi and molecular DNA-based testing in an amniotic fluid cell-pellet or in chorionic villi.

  4. Arthroscopic Bankart repair combined with remplissage technique for the treatment of anterior shoulder instability with engaging Hill-Sachs lesion: a report of 49 cases with a minimum 2-year follow-up.

    PubMed

    Zhu, Yi-Ming; Lu, Yi; Zhang, Jin; Shen, Jie-Wei; Jiang, Chun-Yan

    2011-08-01

    Engaging Hill-Sachs lesions are known to be a risk factor for recurrence dislocation after arthroscopic repair in patients with anterior shoulder instability. For a large engaging Hill-Sachs lesion, arthroscopic remplissage is a solution. Arthroscopic Bankart repair combined with the Hill-Sachs remplissage technique can achieve good results without significant impairment of shoulder function. Case Series; Level of evidence, 4. Forty-nine consecutive patients who underwent arthroscopic Bankart repair and Hill-Sachs remplissage for anterior shoulder instability were followed up for a mean duration of 29.0 months (range, 24-35 months). There were 42 males and 7 females with a mean age of 28.4 years (range, 16.7-54.7 years). All patients had diagnosed traumatic unidirectional anterior shoulder instability with a bony lesion of glenoid and an engaging Hill-Sachs lesion. Physical examination, radiographs, and magnetic resonance imaging were performed during postoperative follow-up. The American Shoulder and Elbow Surgeons (ASES) score, Constant score, and Rowe score were used to evaluate shoulder function. The active forward elevation increased a mean of 8.0° (range, -10° to 80°) postoperatively. However, the patients lost 1.9° (range, -40° to 30°) of external rotation to the side. Significant improvement was detected with regard to the ASES score (84.7 vs 96.0, P < .001), Constant score (93.3 vs 97.8, P = .005), and Rowe score (36.8 vs 89.8, P < .001).There were 1 redislocation, 2 subluxations, and 1 patient with a positive apprehension test; the overall failure rate was 8.2% (4 of 49). Successful healing of the infraspinatus tendon within the Hill-Sachs lesion was shown by magnetic resonance imaging. Arthroscopic Bankart repair combined with Hill-Sachs remplissage can restore shoulder stability without significant impairment of shoulder function in patients with engaging Hill-Sachs lesions.

  5. Axial transition form factors and pion decay of baryon resonances

    SciTech Connect

    Julia-Diaz, B.; Riska, D.O.; Coester, F.

    2004-10-01

    The pion decay constants of the lowest orbitally excited states of the nucleon and the {delta}(1232) along with the corresponding axial transition form factors are calculated with Poincare covariant constituent-quark models with instant, point, and front forms of relativistic kinematics. The model wave functions are chosen such that the calculated electromagnetic and axial form factors of the nucleon represent the empirical values in all three forms of kinematics, when calculated with single-constituent currents. The pion decay widths calculated with the three forms of kinematics are smaller than the empirical values. Front and instant form kinematics provide a similar description, with a slight preference for front form, while the point form values are significantly smaller in the case of the lowest positive parity resonances.

  6. Results of arthroscopic Bankart repair with Hill-Sachs remplissage for anterior shoulder instability.

    PubMed

    Bonnevialle, Nicolas; Azoulay, Vadim; Faraud, Amélie; Elia, Fanny; Swider, Pascal; Mansat, Pierre

    2017-05-11

    The aim of this study was to evaluate mid-term outcomes of Bankart repair with Hill-Sachs remplissage (BHSR) and to highlight prognostic factors of failure. Thirty-four patients operated on for anterior shoulder instability with BHSR were enrolled in a prospective non-randomised study. Clinical and radiographic evaluation was performed at 1.5, three, six months and yearly thereafter. Outcome measures included Rowe and Walch-Duplay score. At mean follow-up of 35 months (24-63), the Rowe and Walch-Duplay scores reached respectively 92.7 and 88.2 points. The mean deficit in external rotation was 6° in ER1 and 1° in ER2 (p = 0.4, p = 0.9 respectively). Five patients (14.7%) had a recurrence of instability and three others had a persistent anterior apprehension. In the failure group, the Hill-Sachs lesion was deeper (26% vs 19% of the humeral diameter; p = 0.04) and range of motion at 1.5 months postoperatively was greater. Age at surgery, pre-operative instability severity index score (ISIS), hyperlaxity, type and level of sport, amount of glenoid bone loss had no correlation with failure rate. The rate of failure at mid-term follow-up of BHSR was higher than commonly reported. The premature recovery of range of motion seems to be a clinical sign of failure at follow-up. Moreover, in case of deep Hill-Sachs lesion (>20%) an alternative procedure should be considered. Level IV.

  7. Strange quark contribution to the nucleon form factor

    NASA Astrophysics Data System (ADS)

    Baunack, S.

    PoS(Confinement8)078 According to QCD, the nucleon is made up of valence quarks, sea quarks and gluons. Concern- ing the quark sea, also strange quarks can contribute to the nucleon properties. Parity violating electron scattering offers a tool to investigate the strange quark contribution to the nucleon form factors parameterized by the strange form factors GE and Gs . The theoretical framework to ac- s M cess these strange form factors is outlined here and an overview of the existing world data is given. The measurements performed by the A4 collaboration at the electron accelerator facility MAMI are described here in more details and preliminary results are reported.

  8. Light-Cone Sum Rule Approach for Baryon Form Factors

    NASA Astrophysics Data System (ADS)

    Offen, Nils

    2016-10-01

    We present the state-of-the-art of the light-cone sum rule approach to Baryon form factors. The essence of this approach is that soft Feynman contributions are calculated in terms of small transverse distance quantities using dispersion relations and duality. The form factors are thus expressed in terms of nucleon wave functions at small transverse separations, called distribution amplitudes, without any additional parameters. The distribution amplitudes, therefore, can be extracted from the comparison with the experimental data on form factors and compared to the results of lattice QCD simulations.

  9. The structure of the nucleon: Elastic electromagnetic form factors

    SciTech Connect

    Punjabi, V.; Perdrisat, C. F.; Jones, M. K.; Brash, E. J.; Carlson, C. E.

    2015-07-10

    Precise proton and neutron form factor measurements at Jefferson Lab, using spin observables, have recently made a significant contribution to the unraveling of the internal structure of the nucleon. Accurate experimental measurements of the nucleon form factors are a test-bed for understanding how the nucleon's static properties and dynamical behavior emerge from QCD, the theory of the strong interactions between quarks. There has been enormous theoretical progress, since the publication of the Jefferson Lab proton form factor ratio data, aiming at reevaluating the picture of the nucleon. We will review the experimental and theoretical developments in this field and discuss the outlook for the future.

  10. Extracting nucleon strange and anapole form factors from data

    SciTech Connect

    R.D. Young; J. Roche; R.D. Carlini; A.W. Thomas

    2006-04-14

    Using the complete world set of parity violating electron scattering data up to Q{sup 2} {approx} 0.3 GeV{sup 2}, we extract the current best determination of the strange electric and magnetic form factors of the proton, as well as the weak axial form factors of the proton and neutron at Q{sup 2} = 0.1 GeV{sup 2}. The results are consistent with state of the art calculations of all four form factors, with the latter including the anapole contribution.

  11. Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients.

    PubMed

    Tropak, Michael B; Reid, Stephen P; Guiral, Marianne; Withers, Stephen G; Mahuran, Don

    2004-04-02

    Tay-Sachs and Sandhoff diseases are lysosomal storage disorders that result from an inherited deficiency of beta-hexosaminidase A (alphabeta). Whereas the acute forms are associated with a total absence of hexosaminidase A and early death, the chronic adult forms exist with activity and protein levels of approximately 5%, and unaffected individuals have been found with only 10% of normal levels. Surprisingly, almost all disease-associated missense mutations do not affect the active site of the enzyme but, rather, inhibit its ability to obtain and/or retain its native fold in the endoplasmic reticulum, resulting in its retention and accelerated degradation. By growing adult Tay-Sachs fibroblasts in culture medium containing known inhibitors of hexosaminidase we have raised the residual protein and activity levels of intralysosomal hexosaminidase A well above the critical 10% of normal levels. A similar effect was observed in fibroblasts from an adult Sandhoff patient. We propose that these hexosaminidase inhibitors function as pharmacological chaperones, enhancing the stability of the native conformation of the enzyme, increasing the amount of hexosaminidase A capable of exiting the endoplasmic reticulum for transport to the lysosome. Therefore, pharmacological chaperones could provide a novel approach to the treatment of adult Tay-Sachs and possibly Sandhoff diseases.

  12. Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients*

    PubMed Central

    Tropak, Michael B.; Reid, Stephen P.; Guiral, Marianne; Withers, Stephen G.; Mahuran, Don

    2010-01-01

    Tay-Sachs and Sandhoff diseases are lysosomal storage disorders that result from an inherited deficiency of β-hexosaminidase A (αβ). Whereas the acute forms are associated with a total absence of hexosaminidase A and early death, the chronic adult forms exist with activity and protein levels of ~5%, and unaffected individuals have been found with only 10% of normal levels. Surprisingly, almost all disease-associated missense mutations do not affect the active site of the enzyme but, rather, inhibit its ability to obtain and/or retain its native fold in the endoplasmic reticulum, resulting in its retention and accelerated degradation. By growing adult Tay-Sachs fibroblasts in culture medium containing known inhibitors of hexosaminidase we have raised the residual protein and activity levels of intralysosomal hexosaminidase A well above the critical 10% of normal levels. A similar effect was observed in fibroblasts from an adult Sandhoff patient. We propose that these hexosaminidase inhibitors function as pharmacological chaperones, enhancing the stability of the native conformation of the enzyme, increasing the amount of hexosaminidase A capable of exiting the endoplasmic reticulum for transport to the lysosome. Therefore, pharmacological chaperones could provide a novel approach to the treatment of adult Tay-Sachs and possibly Sandhoff diseases. PMID:14724290

  13. Atomic form factor for twisted vortex photons interacting with atoms

    NASA Astrophysics Data System (ADS)

    Guthrey, Pierson; Kaplan, Lev; McGuire, J. H.

    2014-04-01

    The relatively new atomic form factor for twisted (vortex) beams, which carry orbital angular momentum (OAM), is considered and compared to the conventional atomic form factor for plane-wave beams that carry only spin angular momentum. Since the vortex symmetry of a twisted photon is more complex that that of a plane wave, evaluation of the atomic form factor is also more complex for twisted photons. On the other hand, the twisted photon has additional parameters, including the OAM quantum number, ℓ, the nodal radial number, p, and the Rayleigh range, zR, which determine the cone angle of the vortex. This Rayleigh range may be used as a variable parameter to control the interaction of twisted photons with matter. Here we address (i) normalization of the vortex atomic form factor, (ii) displacement of target atoms away from the center of the beam vortex, and (iii) formulation of transition probabilities for a variety of photon-atom processes. We attend to features related to experiments that can test the range of validity and accuracy of calculations of these variations of the atomic form factor. Using the absolute square of the form factor for vortex beams, we introduce a vortex factor that can be directly measured.

  14. Classical limit of diagonal form factors and HHL correlators

    NASA Astrophysics Data System (ADS)

    Bajnok, Zoltan; Janik, Romuald A.

    2017-01-01

    We propose an expression for the classical limit of diagonal form factors in which we integrate the corresponding observable over the moduli space of classical solutions. In infinite volume the integral has to be regularized by proper subtractions and we present the one, which corresponds to the classical limit of the connected diagonal form factors. In finite volume the integral is finite and can be expressed in terms of the classical infinite volume diagonal form factors and subvolumes of the moduli space. We analyze carefully the periodicity properties of the finite volume moduli space and found a classical analogue of the Bethe-Yang equations. By applying the results to the heavy-heavy-light three point functions we can express their strong coupling limit in terms of the classical limit of the sine-Gordon diagonal form factors.

  15. Proton Form Factors Measurements in the Time-Like Region

    SciTech Connect

    Anulli, F.; /Frascati

    2007-10-22

    I present an overview of the measurement of the proton form factors in the time-like region. BABAR has recently measured with great accuracy the e{sup +}e{sup -} {yields} p{bar p} reaction from production threshold up to an energy of {approx} 4.5 GeV, finding evidence for a ratio of the electric to magnetic form factor greater than unity, contrary to expectation. In agreement with previous measurements, BABAR confirmed the steep rise of the magnetic form factor close to the p{bar p} mass threshold, suggesting the possible presence of an under-threshold N{bar N} vector state. These and other open questions related to the nucleon form factors both in the time-like and space-like region, wait for more data with different experimental techniques to be possibly solved.

  16. Hadronic Form Factors in Asymptotically Free Field Theories

    DOE R&D Accomplishments Database

    Gross, D. J.; Treiman, S. B.

    1974-01-01

    The breakdown of Bjorken scaling in asymptotically free gauge theories of the strong interactions is explored for its implications on the large q{sup 2} behavior of nucleon form factors. Duality arguments of Bloom and Gilman suggest a connection between the form factors and the threshold properties of the deep inelastic structure functions. The latter are addressed directly in an analysis of asymptotically free theories; and through the duality connection we are then led to statements about the form factors. For very large q{sup 2} the form factors are predicted to fall faster than any inverse power of q{sup 2}. For the more modest range of q{sup 2} reached in existing experiments the agreement with data is fairly good, though this may well be fortuitous. Extrapolations beyond this range are presented.

  17. Pion form factor in the NLC QCD SR approach

    SciTech Connect

    Bakulev, A. P. Pimikov, A. V.; Stefanis, N. G.

    2010-06-15

    We present results of a calculation of the electromagnetic pion form factor within the framework of QCD sum rules with nonlocal condensates and using a perturbative spectral density which includes O({alpha}{sub s}) contributions.

  18. nf2 contributions to fermionic four-loop form factors

    NASA Astrophysics Data System (ADS)

    Lee, Roman N.; Smirnov, Alexander V.; Smirnov, Vladimir A.; Steinhauser, Matthias

    2017-07-01

    We compute the four-loop contributions to the photon quark and Higgs quark form factors involving two closed fermion loops. We present analytical results for all nonplanar master integrals of the two nonplanar integral families which enter our calculation.

  19. Personality Research Form: Factor Structure and Response Style Involvement

    ERIC Educational Resources Information Center

    Stricker, Lawrence J.

    1974-01-01

    Explores factor structure of the Personality Research Form (PRF) and examines the inventory's relations with response styles. In general, the PRF content scales correlate moderately with each other and with measures of acquiescence, social desirability, and defensiveness response biases. (Author)

  20. Flavor decomposition of the elastic nucleon electromagnetic form factors

    SciTech Connect

    C.D. Cates, C.W. Jager, S. Riordan, B. Wojtsekhowski

    2011-06-01

    The u- and d-quark contributions to the elastic nucleon electromagnetic form factors have been determined using experimental data on GEn , GMn , GpE , and GpM . Such a flavor separation of the form factors became possible up to 3.4 GeV2 with recent data on GEn from Hall A at JLab. At a negative four-momentum transfer squared Q2 above 1 GeV2, for both the u- and d-quark components, the ratio of the Pauli form factor to the Dirac form factor, F2/F1, was found to be almost constant, and for each of F2 and F1 individually, the d-quark component drops continuously with increasing Q2.

  1. Charm and bottom hadronic form factors with QCD sum rules

    SciTech Connect

    Bracco, M. E.; Rodrigues, B. O.; Cerqueira, A. Jr.

    2013-03-25

    We present a brief review of some calculations of form factors and coupling constants in vertices with charm and bottom mesons in the framework of QCD sum rules. We first discuss the motivation for this work, describing possible applications of these form factors to charm and bottom decays processes. We first make a summarize of the QCD sum rules method. We give special attention to the uncertainties of the method introducing by the intrinsic variation of the parameters. Finally we conclude.

  2. Strange form factors of octet and decuplet baryons

    SciTech Connect

    Hong, Soon-Tae

    1999-11-22

    The strange form factors of baryon octet are evaluated, in the chiral models with the general chiral SU(3) group structure, to yield the theoretical predictions comparable to the recent experimental data of SAMPLE Collaboration and to study the spin symmetries. Other model predictions are also briefly reviewed to compare with our results and then the strange form factors of baryon octet and decuplet are predicted.

  3. From quarks and gluons to baryon form factors.

    PubMed

    Eichmann, Gernot

    2012-04-01

    I briefly summarize recent results for nucleon and [Formula: see text] electromagnetic, axial and transition form factors in the Dyson-Schwinger approach. The calculation of the current diagrams from the quark-gluon level enables a transparent discussion of common features such as: the implications of dynamical chiral symmetry breaking and quark orbital angular momentum, the timelike structure of the form factors, and their interpretation in terms of missing pion-cloud effects.

  4. From quarks and gluons to baryon form factors

    PubMed Central

    Eichmann, Gernot

    2012-01-01

    I briefly summarize recent results for nucleon and Δ(1232) electromagnetic, axial and transition form factors in the Dyson–Schwinger approach. The calculation of the current diagrams from the quark–gluon level enables a transparent discussion of common features such as: the implications of dynamical chiral symmetry breaking and quark orbital angular momentum, the timelike structure of the form factors, and their interpretation in terms of missing pion-cloud effects. PMID:26766879

  5. Vector Meson Form Factors and Wave Functions from Holographic QCD

    SciTech Connect

    Hovhannes Grigoryan; Anatoly Radyushkin

    2007-10-10

    Based on the holographic dual model of QCD, we study 2- and 3-point functions of vector currents and derive form factors as well as wave functions for the vector mesons. As a result, generalized vector-meson dominance representation for form factors is obtained with a very specific VMD pattern. The calculated electric radius of the rho-meson is shown to be in a good agreement with predictions from lattice QCD.

  6. Future Perspectives on Baryon Form Factor Measurements with BES III

    NASA Astrophysics Data System (ADS)

    Schönning, Karin; Li, Cui

    2017-03-01

    The electromagnetic structure of hadrons, parameterised in terms of electromagnetic form factors, EMFF's, provide a key to the strong interaction. Nucleon EMFF's have been studied rigorously for more than 60 years but the new techniques and larger data samples available at modern facilities have given rise to a renewed interest for the field. Recently, the access to hyperon structure by hyperon time-like EMFF provides an additional dimension. The BEijing Spectrometer (BES III) at the Beijing Electron Positron Collider (BEPC-II) in China is the only running experiment where time-like baryon EMFF's can be studied in the e+e- → BB̅ reaction. The BES III detector is an excellent tool for baryon form factor measurements thanks to its near 4π coverage, precise tracking, PID and calorimetry. All hyperons in the SU(3) spin 1/2 octet and spin 3/2 decuplet are energetically accessible within the BEPC-II energy range. Recent data on proton and Λ hyperon form factors will be presented. Furthermore, a world-leading data sample was collected in 2014-2015 for precision measurements of baryon form factors. In particular, the data will enable a measurement of the relative phase between the electric and the magnetic form factors for Λ and Λc+ and hyperons. The modulus of the phase can be extracted from the hyperon polarisation, which in turn is experimentally accessible via the weak, parity violating decay. Furthermore, from the spin correlation between the outgoing hyperon and antihyperon, the sign of the phase can be extracted. This means that the time-like form factors can be completely determined for the first time. The methods will be outlined and the prospects of the BES III form factor measurements will be given. We will also present a planned upgrade of the BES III detector which is expected to improve future form factor measurements.

  7. [Featuring pathogenicity factors in biofilm-forming and no-biofilm forming strains of Staphylococcus epidermidis].

    PubMed

    Sidashenko, O I; Voronkova, O S; Sirokvasha, O A; Vinnikov, A I

    2015-01-01

    A comparative study of the manifestation of pathogenicity factors: hemolytic, lipase, letsytinase activity and ability to adhere in 20 film-forming and 17 non-film-forming strains of S. epidermidis. Studying pathogenicity factors of the film-forming strains it was found that complete hemolysis and lipase activity shown was by all the film-forming strains of S. epidermidis, letsytinase activity was observed in 80%. Among the non-film-forming strains complete hemolysis and lipase activity were observed in 89% and letsytinase - 71%. Researched non-film-forming and film-forming strains of S. epidermidis showed the ability to adhere to buccal epithelial cells of humans. Found that all the film-forming strains of S. epidermidis were hight level adgesion, the highest IAM was equal to 11,84. It was found that among non-film-forming strains of S. epidermidis were low-, medium- and hight level adgesion. IAM of non-film-forming strains of S. epidermidis is 3 times lower compared to the IAM of the film-forming strains of human epithelial cells and was 3.2.

  8. Online Soil Science Lesson 3: Soil Forming Factors

    USDA-ARS?s Scientific Manuscript database

    This lesson explores the five major factors of soil formation, namely: 1) climate; 2) organisms; 3) time; 4) topography; and 5) parent material and their influence in forming soil. The distinction between active and passive factors, moisture and temperature regimes, organism and topographic influen...

  9. Analytic results for massless three-loop form factors

    NASA Astrophysics Data System (ADS)

    Lee, R. N.; Smirnov, A. V.; Smirnov, V. A.

    2010-04-01

    We evaluate, exactly in d, the master integrals contributing to massless threeloop QCD form factors. The calculation is based on a combination of a method recently suggested by one of the authors (R.L.) with other techniques: sector decomposition implemented in FIESTA, the method of Mellin-Barnes representation, and the PSLQ algorithm. Using our results for the master integrals we obtain analytical expressions for two missing constants in the γ-expansion of the two most complicated master integrals and present the form factors in a completely analytic form.

  10. INTEGRATED SACHS-WOLFE EFFECT FOR GRAVITATIONAL RADIATION

    SciTech Connect

    Laguna, Pablo; Larson, Shane L.; Spergel, David; Yunes, Nicolas

    2010-05-20

    Gravitational waves (GWs) are messengers carrying valuable information about their sources. For sources at cosmological distances, the waves will also contain the imprint left by the intervening matter. The situation is in close analogy with cosmic microwave photons, for which the large-scale structures the photons traverse contribute to the observed temperature anisotropies, in a process known as the integrated Sachs-Wolfe effect. We derive the GW counterpart of this effect for waves propagating on a Friedman-Robertson-Walker background with scalar perturbations. We find that the phase, frequency, and amplitude of the GWs experience Sachs-Wolfe-type integrated effects, in addition to the magnification effects on the amplitude from gravitational lensing. We show that for supermassive black hole binaries, the integrated effects could account for measurable changes on the frequency, chirp mass, and luminosity distance of the binary, thus unveiling the presence of inhomogeneities, and potentially dark energy, in the universe.

  11. Choroidal coloboma in a case of tay-sachs disease.

    PubMed

    Ahmed, Nasreen Raees; Tripathy, Koushik; Kumar, Vivek; Gogia, Varun

    2014-01-01

    Coloboma as an ocular finding has been documented in various syndromes. Here we have a case of infantile Tay-Sachs disease associated with unilateral choroidal coloboma. To the best of our knowledge, such an association has not been documented in the literature. Whether such an association is a matter of chance or signifies the involvement of ganglioside metabolism in ocular embryogenesis remains to be elucidated.

  12. Distribution of a pseudodeficiency allele among Tay-Sachs carriers

    SciTech Connect

    Tomczak, J.; Grebner, E.E. ); Boogen, C. )

    1993-08-01

    Recently Triggs-Raine et al. (1992) identified a new mutation in the gene coding for the [alpha]-subunit of [beta]-hexosaminidase A (hex A), the enzyme whose deficiency causes Tay-Sachs disease. This mutation, a C[sub 739]-to-T transition in exon 7, results in an altered enzyme that is active (albeit at reduced levels) in cells but that has essentially no activity in serum. This so-called pseudodeficient allele was first detected in compound heterozygotes who also carried a Tay-Sachs disease allele and therefore had no detectable hex A in their serum but who were in good health. Carriers of this apparently benign mutation are generally indistinguishable from carriers of a lethal mutation by means of routine enzyme-based screening tests, because the product of the pseudodeficient allele is not detectable in serum and has decreased activity in cells. This suggests that some individuals who have been classified as Tay-Sachs carriers are actually carriers of the pseudodeficient allele and are not at risk to have a child affected with Tay-Sachs disease. The pseudodeficient allele may also be responsible for some inconclusive diagnoses, where leukocyte values fall below the normal range but are still above the carrier range. The fact that there are now two mutant alleles (the psuedodeficient and the adult) that are indistinguishable from the lethal infantile mutations by means of enzyme assay yet that are phenotypically very different and that together may account for as much as 12% of enzyme-defined carriers on the basis of the data here suggests that DNA analysis should be part of a comprehensive screening program. It will be particularly useful to identify the mutations in couples at risk, before they undergo prenatal diagnosis. DNA analysis will also resolve some inconclusive diagnoses.

  13. Modified Sachs's Model of Deformation of Polycrystalline Magnesium

    NASA Astrophysics Data System (ADS)

    Kesarev, A. G.; Vlasova, A. M.

    2017-09-01

    There are a large number of approaches to a description of work hardening of metal polycrystals with various crystal lattices. In the present work, Sachs's model is generalized to uniaxial tension/compression of polycrystalline magnesium with hexagonal densely packed crystal lattice. The tensile yield stress is estimated taking into account two deformation modes: (0001)< 11\\overline{2}0> easy basal slip and (10\\overline{1}2)< \\overline{1}011> twinning.

  14. Kantowski-Sachs universes sourced by a Skyrme fluid

    NASA Astrophysics Data System (ADS)

    Parisi, Luca; Radicella, Ninfa; Vilasi, Gaetano

    2015-03-01

    The Kantowski-Sachs cosmological model sourced by a Skyrme field and a cosmological constant is considered in the framework of general relativity. Assuming a constant radial profile function α =π /2 for the hedgehog ansatz, the Skyrme contribution to Einstein equations is shown to be equivalent to an anisotropic fluid. Using dynamical system techniques, a qualitative analysis of the cosmological equations is presented. Physically interesting features of the model such as isotropization, bounce and recollapse are discussed.

  15. Measurements of the Helium Form Factors at JLab

    SciTech Connect

    Khrosinkova, Elena

    2007-10-26

    An experiment to measure elastic electron scattering off {sup 3}He and {sup 4}He at large momentum transfers is presented. The experiment was carried out in the Hall A Facility of Jefferson Lab. Elastic electron scattering off {sup 3}He was measured at forward and backward electron scattering angles to extract the isotope's charge and magnetic form factors. The charge form factor of {sup 4}He will be extracted from forward-angle electron scattering angle measurements. The data are expected to significantly extend and improve the existing measurements of the three- and four-body form factors. The results will be crucial for the establishment of a canonical standard model for the few-body nuclear systems and for testing predictions of quark dimensional scaling and hybrid nucleon-quark models.

  16. The structure of the nucleon: Elastic electromagnetic form factors

    DOE PAGES

    Punjabi, V.; Perdrisat, C. F.; Jones, M. K.; ...

    2015-07-10

    Precise proton and neutron form factor measurements at Jefferson Lab, using spin observables, have recently made a significant contribution to the unraveling of the internal structure of the nucleon. Accurate experimental measurements of the nucleon form factors are a test-bed for understanding how the nucleon's static properties and dynamical behavior emerge from QCD, the theory of the strong interactions between quarks. There has been enormous theoretical progress, since the publication of the Jefferson Lab proton form factor ratio data, aiming at reevaluating the picture of the nucleon. We will review the experimental and theoretical developments in this field and discussmore » the outlook for the future.« less

  17. Two-loop SL(2) form factors and maximal transcendentality

    NASA Astrophysics Data System (ADS)

    Loebbert, Florian; Sieg, Christoph; Wilhelm, Matthias; Yang, Gang

    2016-12-01

    Form factors of composite operators in the SL(2) sector of N = 4 SYM theory are studied up to two loops via the on-shell unitarity method. The non-compactness of this subsector implies the novel feature and technical challenge of an unlimited number of loop momenta in the integrand's numerator. At one loop, we derive the full minimal form factor to all orders in the dimensional regularisation parameter. At two loops, we construct the complete integrand for composite operators with an arbitrary number of covariant derivatives, and we obtain the remainder functions as well as the dilatation operator for composite operators with up to three covariant derivatives. The remainder functions reveal curious patterns suggesting a hidden maximal uniform transcendentality for the full form factor. Finally, we speculate about an extension of these patterns to QCD.

  18. Nucleon electromagnetic form factors from the covariant Faddeev equation

    NASA Astrophysics Data System (ADS)

    Eichmann, G.

    2011-07-01

    We compute the electromagnetic form factors of the nucleon in the Poincaré-covariant Faddeev framework based on the Dyson-Schwinger equations of QCD. The general expression for a baryon’s electromagnetic current in terms of three interacting dressed quarks is derived. Upon employing a rainbow-ladder gluon-exchange kernel for the quark-quark interaction, the nucleon’s Faddeev amplitude and electromagnetic form factors are computed without any further truncations or model assumptions. The form-factor results show clear evidence of missing pion-cloud effects below a photon momentum transfer of ˜2GeV2 and in the chiral region, whereas they agree well with experimental data at higher photon momenta. Thus, the approach reflects the properties of the nucleon’s quark core.

  19. Measuring Form Factors and Structure Functions with CLAS

    SciTech Connect

    G.P. Gilfoyle

    2007-09-10

    The physics program at the Thomas Jefferson National Accelerator Facility includes a strong effort to measure form factors and structure functions to probe the structure of hadronic matter, reveal the nature of confinement, and develop an understanding of atomic nuclei using quark-gluon degrees of freedom. The CLAS detector is a large acceptance device occupying one of the end stations. We discuss here two programs that use CLAS; measuring the magnetic form factor of the neutron and the virtual photon asymmetry of the proton. The form factor has been measured with unprecedented kinematic coverage and precision up to Q2=4.7 GeV2 and is consistent within 5%-10% of the dipole parameterization. The proton virtual photon asymmetry has been measured across a wide range in Bjorken x. The data exceed the SU(6)-symmetric quark prediction and show evidence of a smooth approach to the scaling limit prescribed by perturbative QCD.

  20. Elastic and transition form factors of the Δ(1232)

    DOE PAGES

    Segovia, Jorge; Chen, Chen; Cloet, Ian C.; ...

    2013-12-10

    Predictions obtained with a confining, symmetry-preserving treatment of a vector Ⓧ vector contact interaction at leading-order in a widely used truncation of QCD’s Dyson–Schwinger equations are presented for Δ and Ω baryon elastic form factors and the γN → Δ transition form factors. This simple framework produces results that are practically indistinguishable from the best otherwise available, an outcome which highlights that the key to describing many features of baryons and unifying them with the properties of mesons is a veracious expression of dynamical chiral symmetry breaking in the hadron bound-state problem. The following specific results are of particular interest.more » The Δ elastic form factors are very sensitive to mΔ. Hence, given that the parameters which define extant simulations of lattice-regularised QCD produce Δ-resonance masses that are very large, the form factors obtained therewith are a poor guide to properties of the Δ(1232). Considering the Δ-baryon’s quadrupole moment, whilst all computations produce a negative value, the conflict between theoretical predictions entails that it is currently impossible to reach a sound conclusion on the nature of the Δ-baryon’s deformation in the infinite momentum frame. Furthermore, results for analogous properties of the Ω baryon are less contentious. In connection with the N → Δ transition, the Ash-convention magnetic transition form factor falls faster than the neutron’s magnetic form factor and nonzero values for the associated quadrupole ratios reveal the impact of quark orbital angular momentum within the nucleon and Δ; and, furthermore, these quadrupole ratios do slowly approach their anticipated asymptotic limits.« less

  1. Elastic and transition form factors of the Δ(1232)

    SciTech Connect

    Segovia, Jorge; Chen, Chen; Cloet, Ian C.; Roberts, Craig D.; Schmidt, Sebastian M.; Wan, Shaolong

    2013-12-10

    Predictions obtained with a confining, symmetry-preserving treatment of a vector Ⓧ vector contact interaction at leading-order in a widely used truncation of QCD’s Dyson–Schwinger equations are presented for Δ and Ω baryon elastic form factors and the γN → Δ transition form factors. This simple framework produces results that are practically indistinguishable from the best otherwise available, an outcome which highlights that the key to describing many features of baryons and unifying them with the properties of mesons is a veracious expression of dynamical chiral symmetry breaking in the hadron bound-state problem. The following specific results are of particular interest. The Δ elastic form factors are very sensitive to mΔ. Hence, given that the parameters which define extant simulations of lattice-regularised QCD produce Δ-resonance masses that are very large, the form factors obtained therewith are a poor guide to properties of the Δ(1232). Considering the Δ-baryon’s quadrupole moment, whilst all computations produce a negative value, the conflict between theoretical predictions entails that it is currently impossible to reach a sound conclusion on the nature of the Δ-baryon’s deformation in the infinite momentum frame. Furthermore, results for analogous properties of the Ω baryon are less contentious. In connection with the N → Δ transition, the Ash-convention magnetic transition form factor falls faster than the neutron’s magnetic form factor and nonzero values for the associated quadrupole ratios reveal the impact of quark orbital angular momentum within the nucleon and Δ; and, furthermore, these quadrupole ratios do slowly approach their anticipated asymptotic limits.

  2. The Proton Form Factor Ratio Measurements at Jefferson Lab

    SciTech Connect

    Punjabi, Vina A.; Perdrisat, Charles F.

    2014-03-01

    The ratio of the proton form factors, G{sub Ep}/G{sub Mp}, has been measured from Q{sup 2} of 0.5 GeV{sup 2} to 8.5 GeV{sup 2}, at the Jefferson Laboratory, using the polarization transfer method. This ratio is extracted directly from the measured ratio of the transverse and longitudinal polarization components of the recoiling proton in elastic electron-proton scattering. The discovery that the proton form factor ratio measured in these experiments decreases approximately linearly with four-momentum transfer, Q{sup 2}, for values above ~1 GeV{sup 2}, is one of the most significant results to come out of JLab. These results have had a large impact on progress in hadronic physics; and have required a significant rethinking of nucleon structure. The increasingly common use of the double-polarization technique to measure the nucleon form factors, in the last 15 years, has resulted in a dramatic improvement of the quality of all four nucleon electromagnetic form factors, G{sub Ep}, G{sub Mp}, G{sub En} and G{sub Mn}. There is an approved experiment at JLab, GEP(V), to continue the ratio measurements to 12 GeV{sup 2}. A dedicated experimental setup, the Super Bigbite Spectrometer (SBS), will be built for this purpose. It will be equipped with a focal plane polarimeter to measure the polarization of the recoil protons. The scattered electrons will be detected in an electromagnetic calorimeter. In this presentation, I will review the status of the proton elastic electromagnetic form factors and discuss a number of theoretical approaches to describe nucleon form factors.

  3. Splice junction mutation in some Ashkenazi Jews with Tay-Sachs disease: Evidence against a single defect within this ethnic group

    SciTech Connect

    Myerowitz, R. )

    1988-06-01

    Tay-Sachs disease is an inherited disorder in which the {alpha} chain of the lysosomal enzyme {beta}-N-acetylhexosaminidase A bears the mutation. Ashkenazi Jews are found to be carriers for a severe type of Tay-Sachs disease, the classic form, 10 times more frequently than the general population. Ashkenazi Jewish patients with classic Tay-Sachs disease have appeared to be clinically and biochemically identical, and the usual assumption has been that they harbor the same {alpha}-chain mutation. The author has isolated the {alpha}-chain gene from an Ashkenazi Jewish patient, GM2968, with classic Tay-Sachs disease and compared its nucleotide sequences with that of the normal {alpha}-chain gene in the promoter region, exon and splice junction regions, and polyadenylylation signal area. Only one difference was observed between these sequences. The alteration is presumed to be functionally significant and to result in aberrant mRNA splicing. Utilizing the polymerase chain reaction to amplify the region encompassing the mutation, the author developed an assay to screen patients and heterozygote carriers for this mutation. Surprisingly, in each of two Ashkenazi patients, only one {alpha}-chain allele harbored the splice junction mutation. Only one parent of each of these patients was positive for the defect. Another Ashkenazi patient did not bear this mutation at all nor did either of the subject's parents. The data are consistent with the presence of more than one mutation underlying the classic form of Tay-Sachs disease in the Ashkenazi Jewish population.

  4. Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.

    PubMed

    Miklyaeva, Elena I; Dong, Weijia; Bureau, Alexandre; Fattahie, Roya; Xu, Yongqin; Su, Meng; Fick, Gordon H; Huang, Jing-Qi; Igdoura, Suleiman; Hanai, Nobuo; Gravel, Roy A

    2004-03-19

    Tay-Sachs disease is an autosomal recessive neurodegenerative disease resulting from a block in the hydrolysis of GM2 ganglioside, an intermediate in ganglioside catabolism. The mouse model of Tay-Sachs disease (Hexa -/-) has been described as behaviorally indistinguishable from wild type until at least 1 year of age due to a sialidase-mediated bypass of the metabolic defect that reduces the rate of GM2 ganglioside accumulation. In this study, we have followed our mouse model to over 2 years of age and have documented a significant disease phenotype that is reminiscent of the late onset, chronic form of human Tay-Sachs disease. Onset occurs at 11-12 months of age and progresses slowly, in parallel with increasing storage of GM2 ganglioside. The disease is characterized by hind limb spasticity, weight loss, tremors, abnormal posture with lordosis, possible visual impairment, and, late in the disease, muscle weakness, clasping of the limbs, and myoclonic twitches of the head. Immunodetection of GM2 ganglioside showed that storage varies widely in different regions, but is most intense in pyriform cortex, hippocampus (CA3 field, subiculum), amygdala, hypothalamus (paraventricular supraoptic, ventromedial and arcuate nuclei, and mammilary body), and the somatosensory cortex (layer V) in 1- to 2-year-old mutant mice. We suggest that the Tay-Sachs mouse model is a phenotypically valid model of disease and may provide for a reliable indicator of the impact of therapeutic strategies, in particular geared to the late onset, chronic form of human Tay-Sachs disease.

  5. Master integrals for the four-loop Sudakov form factor

    NASA Astrophysics Data System (ADS)

    Boels, Rutger H.; Kniehl, Bernd A.; Yang, Gang

    2016-01-01

    The light-like cusp anomalous dimension is a universal function in the analysis of infrared divergences. In maximally (N = 4) supersymmetric Yang-Mills theory (SYM) in the planar limit, it is known, in principle, to all loop orders. The non-planar corrections are not known in any theory, with the first appearing at the four-loop order. The simplest quantity which contains this correction is the four-loop two-point form factor of the stress tensor multiplet. This form factor was largely obtained in integrand form in a previous work for N = 4 SYM, up to a free parameter. In this work, a reduction of the appearing integrals obtained by solving integration-by-parts (IBP) identities using a modified version of Reduze is reported. The form factor is shown to be independent of the remaining parameter at integrand level due to an intricate pattern of cancellations after IBP reduction. Moreover, two of the integral topologies vanish after reduction. The appearing master integrals are cross-checked using independent algebraic-geometry techniques explored in the Mint package. The latter results provide the basis of master integrals applicable to generic form factors, including those in Quantum Chromodynamics. Discrepancies between explicitly solving the IBP relations and the MINT approach are highlighted. Remaining bottlenecks to completing the computation of the four-loop non-planar cusp anomalous dimension in N = 4 SYM and beyond are identified.

  6. Measurement of the Charged Pion Electromagnetic Form Factor

    SciTech Connect

    J. Volmer; David Abbott; H. Anklin; Chris Armstrong; John Arrington; K. Assamagan; Steven Avery; Oliver K. Baker; Henk Blok; C. Bochna; Ed Brash; Herbert Breuer; Nicholas Chant; Jim Dunne; Tom Eden; Rolf Ent; David Gaskell; Ron Gilman; Kenneth Gustafsson; Wendy Hinton; Garth Huber; Hal Jackson; Mark K. Jones; Cynthia Keppel; P.H. Kim; Wooyoung Kim; Andi Klein; Doug Koltenuk; Meme Liang; George Lolos; Allison Lung; David Mack; D. McKee; David Meekins; Joseph Mitchell; H. Mkrtchian; B. Mueller; Gabriel Niculescu; Ioana Niculescu; D. Pitz; D. Potterveld; Liming Qin; Juerg Reinhold; I.K. Shin; Stepan Stepanyan; V. Tadevosian; L.G. Tang; R.L.J. van der Meer; K. Vansyoc; D. Van Westrum; Bill Vulcan; Stephen Wood; Chen Yan; W.X. Zhao; Beni Zihlmann

    2001-02-26

    Separated longitudinal and transverse structure functions for the reaction 1H(e,eprime pi+)n were measured in the momentum transfer region Q2=0.6-1.6 (GeV/c)**2 at a value of the invariant mass W=1.95 GeV. New values for the pion charge form factor were extracted from the longitudinal cross section by using a recently developed Regge model. The results indicate that the pion form factor in this region is larger than previously assumed and is consistent with a monopole parameterization fitted to very low Q2 elastic data.

  7. Pion transition form factor through Dyson-Schwinger equations

    NASA Astrophysics Data System (ADS)

    Raya, Khépani

    2016-10-01

    In the framework of Dyson-Schwinger equations (DSE), we compute the γ*γ→π0 transition form factor, G(Q2). For the first time, in a continuum approach to quantun chromodynamics (QCD), it was possible to compute G(Q2) on the whole domain of space-like momenta. Our result agrees with CELLO, CLEO and Belle collaborations and, with the well- known asymptotic QCD limit, 2ƒπ. Our analysis unifies this prediction with that of the pion's valence-quark parton distribution amplitude (PDA) and elastic electromagnetic form factor.

  8. Reanalysis of Rosenbluth measurements of the proton form factors

    NASA Astrophysics Data System (ADS)

    Gramolin, Alexander; Nikolenko, Dmitry

    2017-01-01

    We have reanalyzed the elastic electron-proton scattering data from SLAC experiments E140 and NE11. This work was motivated by recent progress in calculating the corresponding radiative corrections and by the apparent discrepancy between the Rosenbluth and polarization transfer measurements of the proton electromagnetic form factors. New, corrected values for the scattering cross sections are presented, as well as a new form factor fit in the Q2 range from 1 to 8 . 83GeV2 . Our reanalysis brings the combined results of the SLAC experiments into better agreement with the polarization transfer data, but a significant discrepancy remains for Q2 > 3GeV2 .

  9. Electromagnetic form factors of the Δ with D-waves

    SciTech Connect

    Ramalho, Gilberto T.F.; Pena, Maria Teresa; Gross, Franz L.

    2010-06-01

    The electromagnetic form factors of the Δ baryon are evaluated within the framework of a covariant spectator quark model, where S and D-states are included in the Δ wave function. We predict all the four Δ multipole form factors: the electric charge GE0, the magnetic dipole GM1, the electric quadrupole GE2 and the magnetic octupole GM3. We compare our predictions with other theoretical calculations. Our results are compatible with the available experimental data and recent lattice QCD data.

  10. Electromagnetic Form Factors of Hadrons in Quantum Field Theories

    SciTech Connect

    Dominguez, C. A.

    2008-10-13

    In this talk, recent results are presented of calculations of electromagnetic form factors of hadrons in the framework of two quantum field theories (QFT), (a) Dual-Large N{sub c} QCD (Dual-QCD{sub {infinity}}) for the pion, proton, and {delta}(1236), and (b) the Kroll-Lee-Zumino (KLZ) fully renormalizable Abelian QFT for the pion form factor. Both theories provide a QFT platform to improve on naive (tree-level) Vector Meson Dominance (VMD). Dual-QCD{sub {infinity}} provides a tree-level improvement by incorporating an infinite number of zero-width resonances, which can be subsequently shifted from the real axis to account for the time-like behaviour of the form factors. The renormalizable KLZ model provides a QFT improvement of VMD in the framework of perturbation theory. Due to the relative mildness of the {rho}{pi}{pi} coupling, and the size of loop suppression factors, the perturbative expansion is well defined in spite of this being a strong coupling theory. Both approaches lead to considerable improvements of VMD predictions for electromagnetic form factors, in excellent agreement with data.

  11. Pion Electromagnetic Form Factor in Virtuality Distribution Formalism

    SciTech Connect

    Radyushkin, Anatoly V.

    2016-01-01

    We discuss two applications of the {\\it Virtuality Distribution Amplitudes} (VDA) formalism developed in our recent papers. We start with an overview of the main properties of the pion distribution amplitude emphasizing the quantitative measures of its width, and possibility to access them through the pion transition form factor studies. We formulate the basic concepts of the VDA approach and introduce the pion {\\it transverse momentum distribution amplitude} (TMDA) which plays, in a covariant Lagrangian formulation, a role similar to that of the pion wave function in the 3-dimensional Hamiltonian light-front approach. We propose simple factorized models for soft TMDAs, and use them to describe existing data on the pion transition form factor, thus fixing the scale determining the size of the transverse-momentum effects. Finally, we apply the VDA approach to the one-gluon exchange contribution for the pion electromagnetic form factor. We observe a very late $Q^2 \\gtrsim 20$ GeV$^2$ onset of transition to the asymptotic pQCD predictions and show that in the $Q^2 \\lesssim 10$ GeV$^2$ region there is essentially no sensitivity to the shape of the pion distribution amplitude. Furthermore, the magnitude of the one-gluon exchange contribution in this region is estimated to be an order of magnitude below the Jefferson Lab data, thus leaving the Feynman mechanism as the only one relevant to the pion electromagnetic form factor behavior for accessible $Q^2$.

  12. Perturbative corrections to B → D form factors in QCD

    NASA Astrophysics Data System (ADS)

    Wang, Yu-Ming; Wei, Yan-Bing; Shen, Yue-Long; Lü, Cai-Dian

    2017-06-01

    We compute perturbative QCD corrections to B → D form factors at leading power in Λ/ m b , at large hadronic recoil, from the light-cone sum rules (LCSR) with B-meson distribution amplitudes in HQET. QCD factorization for the vacuum-to- B-meson correlation function with an interpolating current for the D-meson is demonstrated explicitly at one loop with the power counting scheme {m}_c˜ O(√{Λ {m}_b}) . The jet functions encoding information of the hard-collinear dynamics in the above-mentioned correlation function are complicated by the appearance of an additional hard-collinear scale m c , compared to the counterparts entering the factorization formula of the vacuum-to- B-meson correction function for the construction of B → π from factors. Inspecting the next-to-leading-logarithmic sum rules for the form factors of B → Dℓν indicates that perturbative corrections to the hard-collinear functions are more profound than that for the hard functions, with the default theory inputs, in the physical kinematic region. We further compute the subleading power correction induced by the three-particle quark-gluon distribution amplitudes of the B-meson at tree level employing the background gluon field approach. The LCSR predictions for the semileptonic B → Dℓν form factors are then extrapolated to the entire kinematic region with the z-series parametrization. Phenomenological implications of our determinations for the form factors f BD +,0 ( q 2) are explored by investigating the (differential) branching fractions and the R( D) ratio of B → Dℓν and by determining the CKM matrix element |V cb | from the total decay rate of B → Dμν μ .

  13. Nucleon form factors program with SBS at JLAB

    SciTech Connect

    Wojtsekhowski, Bogdan B.

    2014-12-01

    The physics of the nucleon form factors is the basic part of the Jefferson Laboratory program. We review the achievements of the 6-GeV era and the program with the 12- GeV beam with the SBS spectrometer in Hall A, with a focus on the nucleon ground state properties.

  14. Determination of Transverse Charge Density from Kaon Form Factor Data

    NASA Astrophysics Data System (ADS)

    Mejia-Ott, Johann; Horn, Tanja; Pegg, Ian; Mecholski, Nicholas; Carmignotto, Marco; Ali, Salina

    2016-09-01

    At the level of nucleons making up atomic nuclei, among subatomic particles made up of quarks, K-mesons or kaons represent the most simple hadronic system including the heavier strange quark, having a relatively elementary bound state of a quark and an anti-quark as its valence structure. Its electromagnetic structure is then parametrized by a single, dimensionless quantity known as the form factor, the two-dimensional Fourier transform of which yields the quantity of transverse charge density. Transverse charge density, in turn, provides a needed framework for the interpretation of form factors in terms of physical charge and magnetization, both with respect to the propagation of a fast-moving nucleon. To this is added the value of strange quarks in ultimately presenting a universal, process-independent description of nucleons, further augmenting the importance of studying the kaon's internal structure. The pressing character of such research questions directs the present paper, describing the first extraction of transverse charge density from electromagnetic kaon form factor data. The extraction is notably extended to form factor data at recently acquired higher energy levels, whose evaluation could permit more complete phenomenological models for kaon behavior to be proposed. This work was supported in part by NSF Grant PHY-1306227.

  15. Quark and Gluon Form Factors to Three Loops

    SciTech Connect

    Baikov, P. A.; Smirnov, V. A.; Chetyrkin, K. G.; Smirnov, A. V.; Steinhauser, M.

    2009-05-29

    We compute the form factors of the photon-quark-anti-quark vertex and the effective vertex of a Higgs-boson and two gluons to three-loop order within massless perturbative quantum chromodynamics. These results provide building blocks for many third-order cross sections. Furthermore, this is the first calculation of complete three-loop vertex corrections.

  16. The Super Bigbite Project: A Study of Nucleon Form Factors

    SciTech Connect

    Jager, Kees de

    2010-06-01

    A proposed set of instrumentation, collectively referred to as the Super Bigbite project, is presented. Used in three different con figurations it will allow measurements of three nucleon electromagnetic form factors GEn, GEp, and GMn with unprecedented precision to Q2-values up to three times higher than existing data.

  17. Spin-2 form factors at three loop in QCD

    NASA Astrophysics Data System (ADS)

    Ahmed, Taushif; Das, Goutam; Mathews, Prakash; Rana, Narayan; Ravindran, V.

    2015-12-01

    Spin-2 fields are often candidates in physics beyond the Standard Model namely the models with extra-dimensions where spin-2 Kaluza-Klein gravitons couple to the fields of the Standard Model. Also, in the context of Higgs searches, spin-2 fields have been studied as an alternative to the scalar Higgs boson. In this article, we present the complete three loop QCD radiative corrections to the spin-2 quark-antiquark and spin-2 gluon-gluon form factors in SU(N) gauge theory with n f light flavors. These form factors contribute to both quark-antiquark and gluon-gluon initiated processes involving spin-2 particle in the hadronic reactions at the LHC. We have studied the structure of infrared singularities in these form factors up to three loop level using Sudakov integro-differential equation and found that the anomalous dimensions originating from soft and collinear regions of the loop integrals coincide with those of the electroweak vector boson and Higgs form factors confirming the universality of the infrared singularities in QCD amplitudes.

  18. Personality Research Form: Factor Structure and Response Style Involvement.

    ERIC Educational Resources Information Center

    Stricker, Lawrence J.

    The aims of this study were (1) to explore the factor structure of the Personality Research Form (PRF) and (2) to examine the inventory's relations with response styles. In general the PRF content scales correlated moderately with each other and with measures of acquiesence, social desirability, and defensiveness response Biases. Six oblique…

  19. Measurement of the pion form factor at higher energies

    SciTech Connect

    Mack, D.J.

    1994-04-01

    One of the strongest arguments for increasing the nominal CEBAF beam energy to equal or exceed 6 GeV is that one would be able to make quality high Q{sup 2} measurements of the charged pion form factor.

  20. Measurements of Form Factors with the BaBar Experiment

    SciTech Connect

    Li, Selina Z.; /SLAC

    2011-08-25

    Selected recent results on measurements of form factors by the BaBar Collaboration are reviewed, including e{sup +}e{sup -} {yields} {eta}{prime}{gamma}, leptonic and semileptonic charm decays from data collected at or near the {Upsilon}(4S) resonance.

  1. Electromagnetic form factors of heavy flavored vector mesons

    NASA Astrophysics Data System (ADS)

    Priyadarsini, M.; Dash, P. C.; Kar, Susmita; Patra, Sweta P.; Barik, N.

    2016-12-01

    We study the electromagnetic form factors of heavy flavored vector mesons such as (D*,Ds*,J /Ψ ) , (B*,Bs*,ϒ ) via one photon radiative decays (V →P γ ) in the relativistic independent quark (RIQ) model based on a flavor independent average interaction potential in the scalar vector harmonic form. The momentum dependent spacelike (q2<0 ) form factors calculated in this model are analytically continued to the physical timelike region 0 ≤q2≤(MV-MP)2 . The predicted coupling constant gV P γ=FV P(q2=0 ) for real photon case in the limit q2→0 and decay widths Γ (V →P γ ) are found in reasonable agreement with experimental data and other model predictions.

  2. The white matter of the human cerebrum: Part I The occipital lobe by Heinrich Sachs

    PubMed Central

    Forkel, Stephanie J.; Mahmood, Sajedha; Vergani, Francesco; Catani, Marco

    2015-01-01

    This is the first complete translation of Heinrich Sachs' outstanding white matter atlas dedicated to the occipital lobe. This work is accompanied by a prologue by Prof Carl Wernicke who for many years was Sachs' mentor in Breslau and enthusiastically supported his work. PMID:25527430

  3. 75 FR 44031 - Goldman, Sachs & Co., et al.; Notice of Application and Temporary Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... global investment banking and securities firm. Goldman Sachs is registered as an investment adviser with... marketing materials used in connection with residential mortgage-related securities offerings by Goldman... marketing materials, (iv) where Goldman Sachs is the lead underwriter of an offering of residential mortgage...

  4. Octet Baryon Electromagnetic Form Factors in a Relativistic Quark Model

    SciTech Connect

    Gilberto Ramalho, Kazuo Tsushima

    2011-09-01

    We study the octet baryon electromagnetic properties by applying the covariant spectator quark model, and provide covariant parametrization that can be used to study baryon electromagnetic reactions. While we use the lattice QCD data in the large pion mass regime (small pion cloud effects) to determine the parameters of the model in the valence quark sector, we use the nucleon physical and octet baryon magnetic moment data to parameterize the pion cloud contributions. The valence quark contributions for the octet baryon electromagnetic form factors are estimated by extrapolating the lattice parametrization in the large pion mass regime to the physical regime. As for the pion cloud contributions, we parameterize them in a covariant, phenomenological manner, combined with SU(3) symmetry. We also discuss the impact of the pion cloud effects on the octet baryon electromagnetic form factors and their radii.

  5. Flavor Analysis of Nucleon, Δ , and Hyperon Electromagnetic Form Factors

    NASA Astrophysics Data System (ADS)

    Rohrmoser, Martin; Choi, Ki-Seok; Plessas, Willibald

    2017-03-01

    By the analysis of the world data base of elastic electron scattering on the proton and the neutron (for the latter, in fact, on ^2H and ^3He) important experimental insights have recently been gained into the flavor compositions of nucleon electromagnetic form factors. We report on testing the Graz Goldstone-boson-exchange relativistic constituent-quark model in comparison to the flavor contents in low-energy nucleons, as revealed from electron-scattering phenomenology. It is found that a satisfactory agreement is achieved between theory and experiment for momentum transfers up to Q^2˜ 4 GeV^2, relying on three-quark configurations only. Analogous studies have been extended to the Δ and the hyperon electromagnetic form factors. For them we here show only some sample results in comparison to data from lattice quantum chromodynamics.

  6. η' transition form factor from space- and timelike experimental data

    NASA Astrophysics Data System (ADS)

    Escribano, R.; Gonzàlez-Solís, S.; Masjuan, P.; Sanchez-Puertas, P.

    2016-09-01

    The η' transition form factor is reanalyzed in view of the recent first observation by BESIII of the Dalitz decay η'→γ e+e- in both space- and timelike regions at low and intermediate energies using the Padé approximants method. The present analysis provides a suitable parametrization for reproducing the measured form factor in the whole energy region and allows one to extract the corresponding low-energy parameters together with a prediction of their values at the origin, related to Γη'→γ γ , and the asymptotic limit. The η - η' mixing is reassessed within a mixing scheme compatible with the large-Nc chiral perturbation theory at next-to-leading order, with particular attention to the Okubo-Zweig-Iizuka-rule-violating parameters. The J /ψ , Z →η(')γ decays are also considered and predictions are reported.

  7. Precision Rosenbluth measurement of the proton elastic form factors

    SciTech Connect

    I. A. Qattan; J. Arrington; R. E. Segel; X. Zheng; K. Aniol; O. K. Baker; R. Beams; E. J. Brash; J. Calarco; A. Camsonne; J.-P. Chen; M. E. Christy; D. Dutta; R. Ent; S. Frullani; D. Gaskell; O. Gayou; R. Gilman; C. Glashausser; K. Hafidi; J.-O. Hansen; D. W. Higinbotham; W. Hinton; R. J. Holt; G. M. Huber; H. Ibrahim; L. Jisonna; M. K. Jones; C. E. Keppel; E. Kinney; G. J. Kumbartzki; A. Lung; D. J. Margaziotis; K. McCormick; D. Meekins; R. Michaels; P. Monaghan; P. Moussiegt; L. Pentchev; C. Perdrisat; V. Punjabi; R. Ransome; J. Reinhold; B. Reitz; A. Saha; A. Sarty; E. C. Schulte; K. Slifer; P. Solvignon; V. Sulkosky; K. Wijesooriya; B. Zeidman

    2004-10-01

    We report the results of a new Rosenbluth measurement of the proton form factors at Q{sup 2} values of 2.64, 3.20 and 4.10 GeV{sup 2}. Cross sections were determined by detecting the recoiling proton in contrast to previous measurements in which the scattered electron was detected. At each Q{sup 2}, relative cross sections were determined to better than 1%. The measurement focused on the extraction of G{sub E}/G{sub M} which was determined to 4-8% and found to approximate form factor scaling, i.e. {mu}{sub p}G{sub E} {approx} G{sub M}. These results are consistent with and much more precise than previous Rosenbluth extractions. However, they are inconsistent with recent polarization transfer measurements of comparable precision, implying a systematic difference between the two techniques.

  8. Dirac and Pauli form factors from lattice QCD

    SciTech Connect

    Collins, S.; Goeckeler, M.; Nobile, A.; Schaefer, A.; Haegler, Ph.; Horsley, R.; Winter, F.; Zanotti, J. M.; Nakamura, Y.; Pleiter, D.; Rakow, P. E. L.; Schierholz, G.; Schroers, W.; Stueben, H.

    2011-10-01

    We present a comprehensive analysis of the electromagnetic form factors of the nucleon from a lattice simulation with two flavors of dynamical O(a)-improved Wilson fermions. A key feature of our calculation is that we make use of an extensive ensemble of lattice gauge field configurations with four different lattice spacings, multiple volumes, and pion masses down to m{sub {pi}{approx}1}80 MeV. We find that by employing Kelly-inspired parametrizations for the Q{sup 2} dependence of the form factors, we are able to obtain stable fits over our complete ensemble. Dirac and Pauli radii and the anomalous magnetic moments of the nucleon are extracted and results at light quark masses provide evidence for chiral nonanalytic behavior in these fundamental observables.

  9. Precision Measurements of the Proton Elastic Form Factor Ratio

    SciTech Connect

    Douglas Higinbotham

    2010-08-01

    New high precision polarization measurements of the proton elastic form factor ratio in the Q^2 from 0.3 to 0.7 [GeV/c]^2 have been made. These elastic H(e,e'p) measurementswere done in Jefferson Lab's Hall A using 80% longitudinally polarized electrons and recoil polarimetry. For Q^2 greater than 1 [GeV/c]^2, previous polarization data indicated a strong deviation of the form factor ratio from unity which sparked renewed theoretical and experimental interest in how two-photon diagrams have been taken into account. The new high precision data indicate that the deviation from unity, while small, persists even at Q^2 less than 1 [GeV/c]^2.

  10. Reanalysis of Rosenbluth measurements of the proton form factors

    NASA Astrophysics Data System (ADS)

    Gramolin, A. V.; Nikolenko, D. M.

    2016-05-01

    We present a reanalysis of the data from Stanford Linear Accelerator Center (SLAC) experiments E140 [R. C. Walker et al., Phys. Rev. D 49, 5671 (1994), 10.1103/PhysRevD.49.5671] and NE11 [L. Andivahis et al., Phys. Rev. D 50, 5491 (1994), 10.1103/PhysRevD.50.5491] on elastic electron-proton scattering. This work is motivated by recent progress in calculating the corresponding radiative corrections and by the apparent discrepancy between the Rosenbluth and polarization transfer measurements of the proton electromagnetic form factors. New, corrected values for the scattering cross sections are presented, as well as a new form factor fit in the Q2 range from 1 to 8.83 GeV2. We also provide a complete set of revised formulas to account for radiative corrections in single-arm measurements of unpolarized elastic electron-proton scattering.

  11. Two-photon transition form factor of c ¯ quarkonia

    NASA Astrophysics Data System (ADS)

    Chen, Jing; Ding, Minghui; Chang, Lei; Liu, Yu-xin

    2017-01-01

    The two-photon transition of c ¯c quarkonia are studied within a covariant approach based on the consistent truncation scheme of the quantum chromodynamics Dyson-Schwinger equation for the quark propagator and the Bethe-Salpeter equation for the mesons. We find the decay widths of ηc→γ γ and χc 0 ,2→γ γ in good agreement with experimental data. The obtained transition form factor of ηc→γ γ* for a wide range of spacelike photon-momentum-transfer squared is also in agreement with the experimental findings of the BABAR experiment. As a by-product, the decay widths of ηb,χb 0 ,2→γ γ and the transition form factor of ηb,χc 0 ,b 0→γ γ* are predicted, which await experimental testing.

  12. Late-onset Tay-Sachs disease: phenotypic characterization and genotypic correlations in 21 affected patients.

    PubMed

    Neudorfer, Orit; Pastores, Gregory M; Zeng, Bai J; Gianutsos, John; Zaroff, Charles M; Kolodny, Edwin H

    2005-02-01

    The purpose of this study was to describe the phenotype (and corresponding genotype) of adult patients with late-onset Tay-Sachs disease, a clinical variant of the GM2-gangliosidoses. A comprehensive physical examination, including neurological assessments, was performed to establish the current disease pattern and severity. In addition, the patients' past medical histories were reviewed. The patients' alpha-subunit mutations (beta-Hexosaminidase A genotype) were determined and correlated with their corresponding clinical findings and disease course. Twenty-one patients (current mean age: 27.0 years; range: 14-47 years) were identified. The pedigree revealed a relative with the "classic" infantile or late-onset form of Tay-Sachs disease in four (out of 18) unrelated families. The patients were predominantly male (15/21 individuals) and of Ashkenazi Jewish ancestry (15/18 families). Mean age at onset was 18.1 years; balance problems and difficulty climbing stairs were the most frequent presenting complaints. In several cases, the diagnosis was delayed (mean age at diagnosis: 27.0 years). Analysis of the beta-hex A gene revealed the G269S mutation as the most common disease allele; found in homozygosity (N = 1) or heterozygosity (N = 18; including 2 sib pairs). Disease onset (age 36 years) was delayed and progression relatively slower in the homozygous G269S patient. Two siblings (ages 28 and 31 years), of non-Jewish ancestry, were compound heterozygotes (TATC1278/W474C); their clinical course is dominated by psychiatric problems. Brain imaging studies revealed marked cerebellar atrophy in all patients (N = 18) tested, regardless of disease stage. Late-onset Tay-Sachs disease is an infrequent disorder and the diagnosis is often missed or delayed (by approximately 8 years). Early on, the majority of patients develop signs of either cerebellar or anterior motor neuron involvement. Affected individuals may also develop psychotic episodes. In most cases, the later

  13. Stackable Form-Factor Peripheral Component Interconnect Device and Assembly

    NASA Technical Reports Server (NTRS)

    Somervill, Kevin M. (Inventor); Ng, Tak-kwong (Inventor); Torres-Pomales, Wilfredo (Inventor); Malekpour, Mahyar R. (Inventor)

    2013-01-01

    A stackable form-factor Peripheral Component Interconnect (PCI) device can be configured as a host controller or a master/target for use on a PCI assembly. PCI device may comprise a multiple-input switch coupled to a PCI bus, a multiplexor coupled to the switch, and a reconfigurable device coupled to one of the switch and multiplexor. The PCI device is configured to support functionality from power-up, and either control function or add-in card function.

  14. Two-photon exchange corrections to the pion form factor

    DOE PAGES

    Peter G. Blunden; Melnitchouk, Wally; Tjon, John A.

    2010-01-06

    Here, we compute two-photon exchange corrections to the electromagnetic form factor of the pion, taking into account the finite size of the pion. Compared to the soft-photon approximation for the infrared divergent contribution which neglects hadron structure effects, the corrections are found to be ≲ 1% for small Q2 (Q2 < 0.1 GeV2), but increase to several percent for Q2 ≳ 1 GeV2 at extreme backward angles.

  15. Quaternions, Torsion and the Physical Vacuum: Theories of M. Sachs and G. Shipov Compared

    NASA Astrophysics Data System (ADS)

    Cyganski, David; Page, William S.

    Of several developments of unified field theories in the spirit of Einstein's original objective of a fully geometric description of all classical fields as well as quantum mechanics, two are particularly noteworthy. The works of Mendel Sachs and Gennady Shipov stand apart as major life works comprising tens of papers, several monographs and decades of effort. Direct comparison of these theories is hampered however by differences in notation and conceptual view-point. Despite these differences, there are many parallels between the fundamental mathematical structures appearing in each. In this paper we discuss the main tenets of the two approaches and demonstrate that they both give rise to a factorization of the invariant interval of general relativity.

  16. Phenomenological dynamics of loop quantum cosmology in Kantowski-Sachs spacetime

    SciTech Connect

    Chiou, D.-W.

    2008-08-15

    The fundamental theory and the semiclassical description of loop quantum cosmology (LQC) have been studied in the Friedmann-Robertson-Walker and Bianchi I models. As an extension to include both anisotropy and intrinsic curvature, this paper investigates the cosmological model of Kantowski-Sachs spacetime with a free massless scalar field at the level of phenomenological dynamics with the LQC discreteness corrections. The LQC corrections are implemented in two different improved quantization schemes. In both schemes, the big bang and big crunch singularities of the classical solution are resolved and replaced by the big bounces when the area or volume scale factor approaches the critical values in the Planck regime measured by the reference of the scalar field momentum. Symmetries of scaling are also noted and suggest that the fundamental spatial scale (area gap) may give rise to a temporal scale. The bouncing scenarios are in an analogous fashion of the Bianchi I model, naturally extending the observations obtained previously.

  17. Convergent and discriminant validity of the Five Factor Form.

    PubMed

    Rojas, Stephanie L; Widiger, Thomas A

    2014-04-01

    The current study tests the convergent and discriminant validity of a modified version of the Five Factor Model Rating Form (FFMRF), a one-page, brief measure of the five-factor model. The Five Factor Form (FFF) explicitly identifies maladaptive variants for both poles of each of the 30 facets of the FFMRF. The purpose of the current study was to test empirically whether this modified version still provides a valid assessment of the FFM, as well as to compare its validity as a measure of the FFM to other brief FFM measures. Two independent samples of 510 and 330 community adults were sampled, one third of whom had a history of some form of mental health treatment. The FFF was compared with three abbreviated and/or brief measures of the FFM (i.e., the FFMRF, the Ten Item Personality Inventory, and the Big Five Inventory), a more extended measure (i.e., International Personality Item Pool-NEO), an alternative measure of general personality (i.e., the HEXACO-Personality Inventory-Revised), and a measure of maladaptive personality functioning (i.e., the Personality Inventory for Diagnostic and Statistical Manual of Mental Disorders, 5th edition). The results of the current study demonstrated convergent and discriminant validity, even at the single-item facet level. © The Author(s) 2013.

  18. Helicity non-conserving form factor of the proton

    SciTech Connect

    Voutier, E.; Furget, C.; Knox, S.

    1994-04-01

    The study of the hadron structure in the high Q{sup 2} range contributes to the understanding of the mechanisms responsible for the confinement of quarks and gluons. Among the numerous experimental candidates sensitive to these mechanisms, the helicity non-conserving form factor of the proton is a privileged observable since it is controlled by non-perturbative effects. The authors investigate here the feasibility of high Q{sup 2} measurements of this form factor by means of the recoil polarization method in the context of the CEBAF 8 GeV facility. For that purpose, they discuss the development of a high energy proton polarimeter, based on the H({rvec p},pp) elastic scattering, to be placed at the focal plane of a new hadron spectrometer. It is shown that this experimental method significantly improves the knowledge of the helicity non-conserving form factor of the proton up to 10 GeV{sup 2}/c{sup 2}.

  19. Strange vector form factors from parity-violating electron scattering

    SciTech Connect

    Kent Paschke, Anthony Thomas, Robert Michaels, David Armstrong

    2011-06-01

    The simplest models might describe the nucleon as 3 light quarks, but this description would be incomplete without inclusion of the sea of glue and qbar q pairs which binds it. Early indications of a particularly large contribution from strange quarks in this sea to the spin and mass of the nucleon motivated an experimental program examining the role of these strange quarks in the nucleon vector form factors. The strangeness form factors can be extracted from the well-studied electromagnetic structure of the nucleon using parity-violation in electron-nuclear scattering to isolate the effect of the weak interaction. With high luminosity and polarization, and a very stable beam due to its superconducting RF cavities, CEBAF at Jefferson Lab is a precision instrument uniquely well suited to the challenge of measurements of the small parity-violating asymmetries. The techniques and results of the two major Jefferson Lab experimental efforts in parity-violation studies, HAPPEX and G0, as well as efforts to describe the strange form factors in QCD, will be reviewed.

  20. Meson Transition Form Factors in Light-Front Holographic QCD

    SciTech Connect

    Brodsky, Stanley J.; Cao, Fu-Guang; de Teramond, Guy F.; /Costa Rica U.

    2011-06-22

    We study the photon-to-meson transition form factors (TFFs) F{sub M{gamma}}(Q{sup 2}) for {gamma}{gamma}* {yields} M using light-front holographic methods. The Chern-Simons action, which is a natural form in 5-dimensional anti-de Sitter (AdS) space, leads directly to an expression for the photon-to-pion TFF for a class of confining models. Remarkably, the predicted pion TFF is identical to the leading order QCD result where the distribution amplitude has asymptotic form. The Chern-Simons form is local in AdS space and is thus somewhat limited in its predictability. It only retains the q{bar q} component of the pion wavefunction, and further, it projects out only the asymptotic form of the meson distribution amplitude. It is found that in order to describe simultaneously the decay process {pi}{sup 0} {yields} {gamma}{gamma} and the pion TFF at the asymptotic limit, a probability for the q{bar q} component of the pion wavefunction P{sub q{bar q}} = 0.5 is required; thus giving indication that the contributions from higher Fock states in the pion light-front wavefunction need to be included in the analysis. The probability for the Fock state containing four quarks (anti-quarks) which follows from analyzing the hadron matrix elements, P{sub q{bar q}q{bar q}} {approx} 10%, agrees with the analysis of the pion elastic form factor using light-front holography including higher Fock components in the pion wavefunction. The results for the TFFs for the {eta} and {eta}{prime} mesons are also presented. The rapid growth of the pion TFF exhibited by the BABAR data at high Q{sup 2} is not compatible with the models discussed in this article, whereas the theoretical calculations are in agreement with the experimental data for the {eta} and {eta}{prime} TFFs.

  1. Meson transition form factors in light-front holographic QCD

    NASA Astrophysics Data System (ADS)

    Brodsky, Stanley J.; Cao, Fu-Guang; de Téramond, Guy F.

    2011-10-01

    We study the photon-to-meson transition form factors (TFFs) FMγ(Q2) for γγ*→M using light-front holographic methods. The Chern-Simons action, which is a natural form in five-dimensional anti-de Sitter (AdS) space, is required to describe the anomalous coupling of mesons to photons using holographic methods and leads directly to an expression for the photon-to-pion TFF for a class of confining models. Remarkably, the predicted pion TFF is identical to the leading order QCD result where the distribution amplitude has asymptotic form. The Chern-Simons form is local in AdS space and is thus somewhat limited in its predictability. It only retains the qq¯ component of the pion wave function, and further, it projects out only the asymptotic form of the meson distribution amplitude. It is found that in order to describe simultaneously the decay process π0→γγ and the pion TFF at the asymptotic limit, a probability for the qq¯ component of the pion wave function Pqq¯=0.5 is required, thus giving indication that the contributions from higher Fock states in the pion light-front wave function need to be included in the analysis. The probability for the Fock state containing four quarks Pqq¯qq¯˜10%, which follows from analyzing the hadron matrix elements for a dressed current model, agrees with the analysis of the pion elastic form factor using light-front holography including higher Fock components in the pion wave function. The results for the TFFs for the η and η' mesons are also presented. The rapid growth of the pion TFF exhibited by the BABAR data at high Q2 is not compatible with the models discussed in this article, whereas the theoretical calculations are in agreement with the experimental data for the η and η' TFFs.

  2. Unitary evolution for a quantum Kantowski-Sachs cosmology

    NASA Astrophysics Data System (ADS)

    Pal, Sridip; Banerjee, Narayan

    2015-10-01

    It is shown that like the Bianchi I, V and IX models, a Kantowski-Sachs cosmological model also allows unitary evolution on quantization. It has also been shown that this unitarity is not at the expense of anisotropy. Non-unitarity, if there is any, cannot escape notice here, as the evolution is studied against a properly oriented time parameter fixed by the evolution of the fluid. Furthermore, we have constructed a wave packet by superposing different energy eigenstates, thereby establishing unitarity in a non-trivial way, which is a stronger result than an energy eigenstate trivially giving a time independent probability density. For α \

  3. Neutron charge radius and the neutron electric form factor

    SciTech Connect

    Gentile, T. R.; Crawford, C. B.

    2011-05-15

    For nearly forty years, the Galster parametrization has been employed to fit existing data for the neutron electric form factor, G{sub E}{sup n}, vs the square of the four-momentum transfer, Q{sup 2}. Typically this parametrization is constrained to be consistent with experimental data for the neutron charge radius. However, we find that the Galster form does not have sufficient freedom to accommodate reasonable values of the radius without constraining or compromising the fit. In addition, the G{sub E}{sup n} data are now at sufficient precision to motivate a two-parameter fit (or three parameters if we include thermal neutron data). Here we present a modified form of a two-dipole parametrization that allows this freedom and fits both G{sub E}{sup n} (including recent data at both low and high four-momentum transfer) and the charge radius well with simple, well-defined parameters. Analysis reveals that the Galster form is essentially a two-parameter approximation to the two-dipole form but becomes degenerate if we try to extend it naturally to three parameters.

  4. Dispersive analysis of the scalar form factor of the nucleon

    NASA Astrophysics Data System (ADS)

    Hoferichter, M.; Ditsche, C.; Kubis, B.; Meißner, U.-G.

    2012-06-01

    Based on the recently proposed Roy-Steiner equations for pion-nucleon ( πN) scattering [1], we derive a system of coupled integral equations for the π π to overline N N and overline K K to overline N N S-waves. These equations take the form of a two-channel Muskhelishvili-Omnès problem, whose solution in the presence of a finite matching point is discussed. We use these results to update the dispersive analysis of the scalar form factor of the nucleon fully including overline K K intermediate states. In particular, we determine the correction {Δ_{σ }} = σ ( {2M_{π }^2} ) - {σ_{{π N}}} , which is needed for the extraction of the pion-nucleon σ term from πN scattering, as a function of pion-nucleon subthreshold parameters and the πN coupling constant.

  5. Gravitational, shear and matter waves in Kantowski-Sachs cosmologies

    SciTech Connect

    Keresztes, Zoltán; Gergely, László Á.; Forsberg, Mats; Bradley, Michael; Dunsby, Peter K.S. E-mail: forsberg.mats.a.b@gmail.com E-mail: peter.dunsby@uct.ac.za

    2015-11-01

    A general treatment of vorticity-free, perfect fluid perturbations of Kantowski-Sachs models with a positive cosmological constant are considered within the framework of the 1+1+2 covariant decomposition of spacetime. The dynamics is encompassed in six evolution equations for six harmonic coefficients, describing gravito-magnetic, kinematic and matter perturbations, while a set of algebraic expressions determine the rest of the variables. The six equations further decouple into a set of four equations sourced by the perfect fluid, representing forced oscillations and two uncoupled damped oscillator equations. The two gravitational degrees of freedom are represented by pairs of gravito-magnetic perturbations. In contrast with the Friedmann case one of them is coupled to the matter density perturbations, becoming decoupled only in the geometrical optics limit. In this approximation, the even and odd tensorial perturbations of the Weyl tensor evolve as gravitational waves on the anisotropic Kantowski-Sachs background, while the modes describing the shear and the matter density gradient are out of phase dephased by π /2 and share the same speed of sound.

  6. Gravitational, shear and matter waves in Kantowski-Sachs cosmologies

    NASA Astrophysics Data System (ADS)

    Keresztes, Zoltán; Forsberg, Mats; Bradley, Michael; Dunsby, Peter K. S.; Gergely, László Á.

    2015-11-01

    A general treatment of vorticity-free, perfect fluid perturbations of Kantowski-Sachs models with a positive cosmological constant are considered within the framework of the 1+1+2 covariant decomposition of spacetime. The dynamics is encompassed in six evolution equations for six harmonic coefficients, describing gravito-magnetic, kinematic and matter perturbations, while a set of algebraic expressions determine the rest of the variables. The six equations further decouple into a set of four equations sourced by the perfect fluid, representing forced oscillations and two uncoupled damped oscillator equations. The two gravitational degrees of freedom are represented by pairs of gravito-magnetic perturbations. In contrast with the Friedmann case one of them is coupled to the matter density perturbations, becoming decoupled only in the geometrical optics limit. In this approximation, the even and odd tensorial perturbations of the Weyl tensor evolve as gravitational waves on the anisotropic Kantowski-Sachs background, while the modes describing the shear and the matter density gradient are out of phase dephased by π /2 and share the same speed of sound.

  7. Integrated Sachs-Wolfe effect in interacting dark energy models

    SciTech Connect

    Olivares, German; Pavon, Diego; Atrio-Barandela, Fernando

    2008-05-15

    Models with dark energy decaying into dark matter have been proposed in cosmology to solve the coincidence problem. We study the effect of such coupling on the cosmic microwave background temperature anisotropies. The interaction changes the rate of evolution of the metric potentials and the growth rate of matter density perturbations and modifies the integrated Sachs-Wolfe component of cosmic microwave background temperature anisotropies, enhancing the effect. Cross correlation of galaxy catalogs with cosmic microwave background maps provides a model-independent test to constrain the interaction. We particularize our analysis for a specific interacting model and show that galaxy catalogs with median redshifts z{sub m}=0.1-0.9 can rule out models with an interaction parameter strength of c{sup 2}{approx_equal}0.1 better than 99.95% confidence level. Values of c{sup 2}{<=}0.01 are compatible with the data and may account for the possible discrepancy between the fraction of dark energy derived from Wilkinson microwave anisotropy probe 3 yr data and the fraction obtained from the integrated Sachs-Wolfe effect. Measuring the fraction of dark energy by these two methods could provide evidence of an interaction.

  8. Bonner Prize: The Elastic Form Factors of the Nucleon

    NASA Astrophysics Data System (ADS)

    Perdrisat, Charles F.

    2017-01-01

    A series of experiments initiated in 1998 at the then new Continuous Electron Beam Accelerator, or CEBAF in Newport News Virginia, resulted in unexpected results, changing significantly our understanding of the structure of the proton. These experiments used a relatively new technique to obtain the ratio of the two form factors of the proton, namely polarization. An intense beam of highly polarized electrons with energy up to 6 GeV was made to interact elastically with un-polarized protons in a hydrogen target. The polarization of the recoiling protons, with energies up to 5 GeV, was measured from a second interaction in a polarimeter consisting of blocs of graphite or CH2 and tracking wire chambers. The scattered electrons were detected in an electromagnetic lead-glass calorimeter, to select elastically scattered events. After a short introduction describing the path which brought me from the University of Geneva to the College of William and Mary in 1966, I will introduce the subject of elastic electron scattering, describe some of the apparatus required for such experiments, and show the results which were unexpected at the time. These results demonstrated unequivocally that the two form factors required to describe elastic ep scattering, electric GE and magnetic GM in the Born approximation, had a drastically different dependence upon the four-momentum squared q2 = q2 -ω2 with q the momentum, and ω the energy transferred in the reaction. The finding, in flagrant disagreement with the data available at the time, which had been obtained dominantly from cross section measurements of the type first used by Nobel Prize R. Hofstadter 60 years ago, have led to a reexamination of the information provided by form factors on the structure of the nucleon, in particular its quark-gluon content. The conclusion will then be a brief outline of several theoretical considerations to put the results in a proper perspective.

  9. Measurement of the π0 electromagnetic transition form factor slope

    NASA Astrophysics Data System (ADS)

    Lazzeroni, C.; Lurkin, N.; Romano, A.; Blazek, T.; Koval, M.; Ceccucci, A.; Danielsson, H.; Falaleev, V.; Gatignon, L.; Goy Lopez, S.; Hallgren, B.; Maier, A.; Peters, A.; Piccini, M.; Riedler, P.; Frabetti, P. L.; Gersabeck, E.; Kekelidze, V.; Madigozhin, D.; Misheva, M.; Molokanova, N.; Movchan, S.; Potrebenikov, Yu.; Shkarovskiy, S.; Zinchenko, A.; Rubin, P.; Baldini, W.; Cotta Ramusino, A.; Dalpiaz, P.; Fiorini, M.; Gianoli, A.; Norton, A.; Petrucci, F.; Savrié, M.; Wahl, H.; Bizzeti, A.; Bucci, F.; Iacopini, E.; Lenti, M.; Veltri, M.; Antonelli, A.; Moulson, M.; Raggi, M.; Spadaro, T.; Eppard, K.; Hita-Hochgesand, M.; Kleinknecht, K.; Renk, B.; Wanke, R.; Winhart, A.; Winston, R.; Bolotov, V.; Duk, V.; Gushchin, E.; Ambrosino, F.; Di Filippo, D.; Massarotti, P.; Napolitano, M.; Palladino, V.; Saracino, G.; Anzivino, G.; Imbergamo, E.; Piandani, R.; Sergi, A.; Cenci, P.; Pepe, M.; Costantini, F.; Doble, N.; Giudici, S.; Pierazzini, G.; Sozzi, M.; Venditti, S.; Balev, S.; Collazuol, G.; DiLella, L.; Gallorini, S.; Goudzovski, E.; Lamanna, G.; Mannelli, I.; Ruggiero, G.; Cerri, C.; Fantechi, R.; Kholodenko, S.; Kurshetsov, V.; Obraztsov, V.; Semenov, V.; Yushchenko, O.; D'Agostini, G.; Leonardi, E.; Serra, M.; Valente, P.; Fucci, A.; Salamon, A.; Bloch-Devaux, B.; Peyaud, B.; Engelfried, J.; Coward, D.; Kozhuharov, V.; Litov, L.; Arcidiacono, R.; Bifani, S.; Biino, C.; Dellacasa, G.; Marchetto, F.; Numao, T.; Retière, F.

    2017-05-01

    The NA62 experiment collected a large sample of charged kaon decays in 2007 with a highly efficient trigger for decays into electrons. A measurement of the π0 electromagnetic transition form factor slope parameter from 1.11 ×106 fully reconstructed K± →π± πD0, πD0 →e+e- γ events is reported. The measured value a = (3.68 ± 0.57) ×10-2 is in good agreement with theoretical expectations and previous measurements, and represents the most precise experimental determination of the slope in the time-like momentum transfer region.

  10. Proton Form Factor Measurements Using Polarization Method: Beyond Born Approximation

    SciTech Connect

    Pentchev, Lubomir

    2008-10-13

    Significant theoretical and experimental efforts have been made over the past 7 years aiming to explain the discrepancy between the proton form factor ratio data obtained at JLab using the polarization method and the previous Rosenbluth measurements. Preliminary results from the first high precision polarization experiment dedicated to study effects beyond Born approximation will be presented. The ratio of the transferred polarization components and, separately, the longitudinal polarization in ep elastic scattering have been measured at a fixed Q{sup 2} of 2.5 GeV{sup 2} over a wide kinematic range. The two quantities impose constraints on the real part of the ep elastic amplitudes.

  11. Neutral pion form factor measurement by the NA62 experiment

    NASA Astrophysics Data System (ADS)

    Zamkovsky, Michal; Ambrosino, F.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Baldini, W.; Balev, S.; Batley, J. R.; Behler, M.; Bifani, S.; Biino, C.; Bizzeti, A.; Blazek, T.; Bloch-Devaux, B.; Bocquet, G.; Bolotov, V.; Bucci, F.; Cabibbo, N.; Calvetti, M.; Cartiglia, N.; Ceccucci, A.; Cenci, P.; Cerri, C.; Cheshkov, C.; Chze, J. B.; Clemencic, M.; Collazuol, G.; Costantini, F.; Cotta Ramusino, A.; Coward, D.; Cundy, D.; Dabrowski, A.; DAgostini, G.; Dalpiaz, P.; Damiani, C.; Danielsson, H.; De Beer, M.; Dellacasa, G.; Derr, J.; Dibon, H.; Di Filippo, D.; DiLella, L.; Doble, N.; Duk, V.; Engelfried, J.; Eppard, K.; Falaleev, V.; Fantechi, R.; Fidecaro, M.; Fiorini, L.; Fiorini, M.; Fonseca Martin, T.; Frabetti, P. L.; Fucci, A.; Gallorini, S.; Gatignon, L.; Gersabeck, E.; Gianoli, A.; Giudici, S.; Gonidec, A.; Goudzovski, E.; Goy Lopez, S.; Gushchin, E.; Hallgren, B.; Hita-Hochgesand, M.; Holder, M.; Hristov, P.; Iacopini, E.; Imbergamo, E.; Jeitler, M.; Kalmus, G.; Kekelidze, V.; Kleinknecht, K.; Koval, M.; Kozhuharov, V.; Kubischta, W.; Kurshetsov, V.; Lamanna, G.; Lazzeroni, C.; Lenti, M.; Leonardi, E.; Litov, L.; Lurkin, N.; Madigozhin, D.; Maier, A.; Mannelli, I.; Marchetto, F.; Marel, G.; Markytan, M.; Marouelli, P.; Martini, M.; Masetti, L.; Massarotti, P.; Mazzucato, E.; Michetti, A.; Mikulec, I.; Misheva, M.; Molokanova, N.; Monnier, E.; Moosbrugger, U.; Morales Morales, C.; Moulson, M.; Movchan, S.; Munday, D. J.; Napolitano, M.; Nappi, A.; Neuhofer, G.; Norton, A.; Numao, T.; Obraztsov, V.; Palladino, V.; Patel, M.; Pepe, M.; Peters, A.; Petrucci, F.; Petrucci, M. C.; Peyaud, B.; Piandani, R.; Piccini, M.; Pierazzini, G.; Polenkevich, I.; Popov, I.; Potrebenikov, Y.; Raggi, M.; Renk, B.; Retire, F.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Salamon, A.; Saracino, G.; Savri, M.; Scarpa, M.; Semenov, V.; Sergi, A.; Serra, M.; Shieh, M.; Shkarovskiy, S.; Slater, M. W.; Sozzi, M.; Spadaro, T.; Stoynev, S.; Swallow, E.; Szleper, M.; Valdata-Nappi, M.; Valente, P.; Vallage, B.; Velasco, M.; Veltri, M.; Venditti, S.; Wache, M.; Wahl, H.; Walker, A.; Wanke, R.; Widhalm, L.; Winhart, A.; Winston, R.; Wood, M. D.; Wotton, S. A.; Yushchenko, O.; Zinchenko, A.; Ziolkowski, M.

    2017-07-01

    The NA62 experiment at CERN collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. The kaon beam represents a source of tagged neutral pion decays in vacuum. A measurement of the electromagnetic transition form factor slope of the neutral pion in the time-like region from ∼1 million fully reconstructed π 0 Dalitz decay is presented. The limits on dark photon production in π 0 decays from the earlier kaon experiment at CERN, NA48/2, are also reported.

  12. Neutral pion form factor measurement by the NA62 experiment

    NASA Astrophysics Data System (ADS)

    Pepe, Monica

    2017-03-01

    The NA62 experiment at CERN collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. A measurement of the electromagnetic transition form factor slope of the neutral pion in the time-like region from about one million fully reconstructed π0 Dalitz decays is presented. The limits on dark photon production from a sample of about 1.7 × 107 π0 Dalitz decays collected in 2003-2004 by the earlier kaon experiment at CERN NA48/2 are also reported.

  13. Proton Elastic Form Factor Ratio: the JLab Polarization Experiments

    SciTech Connect

    Charles Perdrisat; Vina Punjabi

    2003-07-30

    The ratio of the electric and magnetic proton form factors, G{sub Ep}/G{sub Mp}, has been obtained in two Hall A experiments, from measurements of the longitudinal and transverse polarization of the recoil proton, P{sub l} and P{sub t}, respectively, in the elastic scattering of polarized electrons, {rvec e}p {yields} e{rvec p}. Together these experiments cover the Q{sup 2}-range 0.5 to 5.6 GeV{sup 2}. A new experiment is currently being prepared, to extend the Q{sup 2}-range to 9 GeV{sup 2} in Hall C.

  14. Two-photon exchange corrections to the pion form factor

    SciTech Connect

    Peter G. Blunden; Melnitchouk, Wally; Tjon, John A.

    2010-01-06

    Here, we compute two-photon exchange corrections to the electromagnetic form factor of the pion, taking into account the finite size of the pion. Compared to the soft-photon approximation for the infrared divergent contribution which neglects hadron structure effects, the corrections are found to be ≲ 1% for small Q2 (Q2 < 0.1 GeV2), but increase to several percent for Q2 ≳ 1 GeV2 at extreme backward angles.

  15. CEBAF at higher energies and the kaon electromagnetic form factor

    SciTech Connect

    Baker, O.K.

    1994-04-01

    The electromagnetic production of strangeness, the physics of exciting systems having strangeness degrees of freedom (production of hadrons with one or more strange constituent quarks) using electromagnetic probes (real or virtual photons), is one of the frontier areas of research which will be investigated at the Continuous Electron Beam Accelerator Facility (CEBAF) when it becomes operational. CEBAF is expected to have an important impact upon this field of research using its specialized set of detection instruments and high quality electron beam. This paper focusses upon one aspect of the associated production of strangeness - the determination of the kaon electromagnetic form factor at high squared momentum transfers.

  16. Introducing soil forming factors with mini campus field trips

    NASA Astrophysics Data System (ADS)

    Quinton, John; Haygarth, Phil

    2013-04-01

    Students like field work, yet the proportion of time spent in the field during many soil science courses is small. Here we describe an introductory lecture on the soil forming factors based around a mini field trip in which we spend 45 minutes exploring these factors on the Lancaster University campus. In the 'trip' we visit some woodland to consider the effects of organic matter , vegetation and time on soil development and then take in a football pitch to examine the effects of landscape position, parent material and climate. Student responses are overwhelmingly positive and we suggest that more use can be made of our often mundane surroundings to explore soil formation. Soil functions and soil processes.

  17. Meson transition form factors in light-front holographic QCD

    SciTech Connect

    Brodsky, Stanley J.; Cao Fuguang; de Teramond, Guy F.

    2011-10-01

    We study the photon-to-meson transition form factors (TFFs) F{sub M}{gamma}(Q{sup 2}) for {gamma}{gamma}{sup *}{yields}M using light-front holographic methods. The Chern-Simons action, which is a natural form in five-dimensional anti-de Sitter (AdS) space, is required to describe the anomalous coupling of mesons to photons using holographic methods and leads directly to an expression for the photon-to-pion TFF for a class of confining models. Remarkably, the predicted pion TFF is identical to the leading order QCD result where the distribution amplitude has asymptotic form. The Chern-Simons form is local in AdS space and is thus somewhat limited in its predictability. It only retains the qq component of the pion wave function, and further, it projects out only the asymptotic form of the meson distribution amplitude. It is found that in order to describe simultaneously the decay process {pi}{sup 0}{yields}{gamma}{gamma} and the pion TFF at the asymptotic limit, a probability for the qq component of the pion wave function P{sub qq}=0.5 is required, thus giving indication that the contributions from higher Fock states in the pion light-front wave function need to be included in the analysis. The probability for the Fock state containing four quarks P{sub qqqq}{approx}10%, which follows from analyzing the hadron matrix elements for a dressed current model, agrees with the analysis of the pion elastic form factor using light-front holography including higher Fock components in the pion wave function. The results for the TFFs for the {eta} and {eta}{sup '} mesons are also presented. The rapid growth of the pion TFF exhibited by the BABAR data at high Q{sup 2} is not compatible with the models discussed in this article, whereas the theoretical calculations are in agreement with the experimental data for the {eta} and {eta}{sup '} TFFs.

  18. Structural consequences of amino acid substitutions causing Tay-Sachs disease.

    PubMed

    Ohno, Kazuki; Saito, Seiji; Sugawara, Kanako; Sakuraba, Hitoshi

    2008-08-01

    To determine the structural changes in the alpha-subunit of beta-hexosaminidase due to amino acid substitutions causing Tay-Sachs disease, we built structural models of mutant alpha-subunits resulting from 33 missense mutations (24 infantile and 9 late-onset), and analyzed the influence of each amino acid replacement on the structure by calculating the number of atoms affected and determining the solvent-accessible surface area of the corresponding amino acid residue in the wild-type alpha-subunit. In the infantile Tay-Sachs group, the number of atoms influenced by a mutation was generally larger than that in the late-onset Tay-Sachs group in both the main chain and the side chain, and residues associated with the mutations found in the infantile Tay-Sachs group tended to be less solvent-accessible than those in the late-onset Tay-Sachs group. Furthermore, color imaging determined the distribution and degree of the structural changes caused by representative amino acid substitutions, and that there were also differences between the infantile and late-onset Tay-Sachs disease groups. Structural study is useful for elucidating the basis of Tay-Sachs disease.

  19. Polymer waveguide technology: optical connectivity for small form factor applications

    NASA Astrophysics Data System (ADS)

    Lizotte, Todd

    2010-08-01

    Planar polymer waveguides provide opportunities for small form factor distribution of laser light for communication, energy transfer and triggering devices used in the field of optically initiated arming, safing, fusing and firing. The two primary methods or classes of polymer waveguide technology use photolithographic processes both mask and maskless techniques. A waveguide is a device that controls the propagation of an electromagnetic wave so that the wave is forced to follow a path defined by the physical structure of the guide. Fabrication takes the form of both a ridge technology (ridge or trench formed by an embossing or etching method) and the second fabrication technique and the subject of this paper is termed Diffusion Technology [1]. This method includes the formation of a high refractive index waveguide by monomer diffusion into the light-exposed guide forming region with no mechanical or chemical etching contact. An essential process feature here is the photomask-defined light exposure of a mobile monomer waveguide forming region in a polymer matrix that converts the monomer to a polymer. The process of continued monomer diffusion into the surrounding guide imaged region increases the density. The addition of other laminated monomer/polymer diffusing layers with the typical three-plus layer configuration is completely photopolymerized after diffusion is complete. The essential steps include a light induced imaging reaction, a total polymerization light fixing for the entire film, and final cure, all using pre-coated dry materials without waveguide side wall contact. Light and molecular diffusion determine the guide walls [1]. This paper will provide testing results and information on the state of polymer waveguides, the methods of fabrication and the general conditions that these waveguides can operate under. The use of polymer waveguides for connectivity has sufficiently advanced, is practical and available for consideration in near term application

  20. Measurement of the Λb0 decay form factor

    NASA Astrophysics Data System (ADS)

    Abdallah, J.; Abreu, P.; Adam, W.; Adzic, P.; Albrecht, T.; Alderweireld, T.; Alemany-Fernandez, R.; Allmendinger, T.; Allport, P. P.; Amaldi, U.; Amapane, N.; Amato, S.; Anashkin, E.; Andreazza, A.; Andringa, S.; Anjos, N.; Antilogus, P.; Apel, W.-D.; Arnoud, Y.; Ask, S.; Asman, B.; Augustin, J. E.; Augustinus, A.; Baillon, P.; Ballestrero, A.; Bambade, P.; Barbier, R.; Bardin, D.; Barker, G.; Baroncelli, A.; Battaglia, M.; Baubillier, M.; Becks, K.-H.; Begalli, M.; Behrmann, A.; Ben-Haim, E.; Benekos, N.; Benvenuti, A.; Berat, C.; Berggren, M.; Berntzon, L.; Bertrand, D.; Besancon, M.; Besson, N.; Bloch, D.; Blom, M.; Bluj, M.; Bonesini, M.; Boonekamp, M.; Booth, P. S. L.; Borisov, G.; Botner, O.; Bouquet, B.; Bowcock, T. J. V.; Boyko, I.; Bracko, M.; Brenner, R.; Brodet, E.; Bruckman, P.; Brunet, J. M.; Bugge, L.; Buschmann, P.; Calvi, M.; Camporesi, T.; Canale, V.; Carena, F.; Castro, N.; Cavallo, F.; Chapkin, M.; Charpentier, Ph.; Checchia, P.; Chierici, R.; Chliapnikov, P.; Chudoba, J.; Chung, S. U.; Cieslik, K.; Collins, P.; Contri, R.; Cosme, G.; Cossutti, F.; Costa, M. J.; Crawley, B.; Crennell, D.; Cuevas, J.; D'Hondt, J.; Dalmau, J.; da Silva, T.; da Silva, W.; Della Ricca, G.; de Angelis, A.; de Boer, W.; de Clercq, C.; de Lotto, B.; de Maria, N.; de Min, A.; de Paula, L.; di Ciaccio, L.; di Simone, A.; Doroba, K.; Drees, J.; Dris, M.; Eigen, G.; Ekelof, T.; Ellert, M.; Elsing, M.; Espirito Santo, M. C.; Fanourakis, G.; Fassouliotis, D.; Feindt, M.; Fernandez, J.; Ferrer, A.; Ferro, F.; Flagmeyer, U.; Foeth, H.; Fokitis, E.; Fulda-Quenzer, F.; Fuster, J.; Gandelman, M.; Garcia, C.; Gavillet, Ph.; Gazis, E.; Gokieli, R.; Golob, B.; Gomez-Ceballos, G.; Goncalves, P.; Graziani, E.; Grosdidier, G.; Grzelak, K.; Guy, J.; Haag, C.; Hallgren, A.; Hamacher, K.; Hamilton, K.; Haug, S.; Hauler, F.; Hedberg, V.; Hennecke, M.; Herr, H.; Hoffman, J.; Holmgren, S.-O.; Holt, P. J.; Houlden, M. A.; Hultqvist, K.; Jackson, J. N.; Jarlskog, G.; Jarry, P.; Jeans, D.; Johansson, E. K.; Johansson, P. D.; Jonsson, P.; Joram, C.; Jungermann, L.; Kapusta, F.; Katsanevas, S.; Katsoufis, E.; Kernel, G.; Kersevan, B. P.; Kerzel, U.; Kiiskinen, A.; King, B. T.; Kjaer, N. J.; Kluit, P.; Kokkinias, P.; Kourkoumelis, C.; Kouznetsov, O.; Krumstein, Z.; Kucharczyk, M.; Lamsa, J.; Leder, G.; Ledroit, F.; Leinonen, L.; Leitner, R.; Lemonne, J.; Lepeltier, V.; Lesiak, T.; Liebig, W.; Liko, D.; Lipniacka, A.; Lopes, J. H.; Lopez, J. M.; Loukas, D.; Lutz, P.; Lyons, L.; MacNaughton, J.; Malek, A.; Maltezos, S.; Mandl, F.; Marco, J.; Marco, R.; Marechal, B.; Margoni, M.; Marin, J.-C.; Mariotti, C.; Markou, A.; Martinez-Rivero, C.; Masik, J.; Mastroyiannopoulos, N.; Matorras, F.; Matteuzzi, C.; Mazzucato, F.; Mazzucato, M.; McNulty, R.; Meroni, C.; Meyer, W. T.; Miagkov, A.; Migliore, E.; Mitaroff, W.; Mjoernmark, U.; Moa, T.; Moch, M.; Moenig, K.; Monge, R.; Montenegro, J.; Moraes, D.; Moreno, S.; Morettini, P.; Mueller, U.; Muenich, K.; Mulders, M.; Mundim, L.; Murray, W.; Muryn, B.; Myatt, G.; Myklebust, T.; Nassiakou, M.; Navarria, F.; Nawrocki, K.; Nicolaidou, R.; Nikolenko, M.; Oblakowska-Mucha, A.; Obraztsov, V.; Olshevski, A.; Onofre, A.; Orava, R.; Osterberg, K.; Ouraou, A.; Oyanguren, A.; Paganoni, M.; Paiano, S.; Palacios, J. P.; Palka, H.; Papadopoulou, Th. D.; Pape, L.; Parkes, C.; Parodi, F.; Parzefall, U.; Passeri, A.; Passon, O.; Peralta, L.; Perepelitsa, V.; Perrotta, A.; Petrolini, A.; Piedra, J.; Pieri, L.; Pierre, F.; Pimenta, M.; Piotto, E.; Podobnik, T.; Poireau, V.; Pol, M. E.; Polok, G.; Poropat, P.; Pozdniakov, V.; Pukhaeva, N.; Pullia, A.; Rames, J.; Ramler, L.; Read, A.; Rebecchi, P.; Rehn, J.; Reid, D.; Reinhardt, R.; Renton, P.; Richard, F.; Ridky, J.; Rivero, M.; Rodriguez, D.; Romero, A.; Ronchese, P.; Rosenberg, E.; Roudeau, P.; Rovelli, T.; Ruhlmann-Kleider, V.; Ryabtchikov, D.; Sadovsky, A.; Salmi, L.; Salt, J.; Savoy-Navarro, A.; Schwickerath, U.; Segar, A.; Sekulin, R.; Siebel, M.; Sisakian, A.; Smadja, G.; Smirnova, O.; Sokolov, A.; Sopczak, A.; Sosnowski, R.; Spassov, T.; Stanitzki, M.; Stocchi, A.; Strauss, J.; Stugu, B.; Szczekowski, M.; Szeptycka, M.; Szumlak, T.; Tabarelli, T.; Taffard, A. C.; Tegenfeldt, F.; Timmermans, J.; Tkatchev, L.; Tobin, M.; Todorovova, S.; Tome, B.; Tonazzo, A.; Tortosa, P.; Travnicek, P.; Treille, D.; Tristram, G.; Trochimczuk, M.; Troncon, C.; Turluer, M.-L.; Tyapkin, I. A.; Tyapkin, P.; Tzamarias, S.; Uvarov, V.; Valenti, G.; van Dam, P.; van Eldik, J.; van Lysebetten, A.; van Remortel, N.; van Vulpen, I.; Vegni, G.; Veloso, F.; Venus, W.; Verdier, P.; Verzi, V.; Vilanova, D.; Vitale, L.; Vrba, V.; Wahlen, H.; Washbrook, A. J.; Weiser, C.; Wicke, D.; Wickens, J.; Wilkinson, G.; Winter, M.; Witek, M.; Yushchenko, O.; Zalewska, A.; Zalewski, P.; Zavrtanik, D.; Zhuravlov, V.; Zimin, N. I.; Zintchenko, A.; Zupan, M.; Delphi Collaboration

    2004-04-01

    The form factor of Λb0 baryons is estimated using 3.46×106 hadronic Z decays collected by the DELPHI experiment between 1992 and 1995. Charmed Λc+ baryons fully reconstructed in the pK-π+, pK0S, and Λπ+π+π- modes, are associated to a lepton with opposite charge in order to select Λb0→Λc+l-ν¯l decays. From a combined likelihood and event rate fit to the distribution of the Isgur-Wise variable w, and using the Heavy Quark Effective Theory (HQET), the slope of the b-baryon form factor is measured to be ρ̂2=2.03±0.46(stat)+0.72-1.00(syst). The exclusive semileptonic branching fraction Br(Λb0→Λc+l-ν¯l) can be derived from ρ̂2 and is found to be (5.0+1.1-0.8(stat)+1.6-1.2(syst))%. Limits on other branching fractions are also obtained.

  1. Measurement of the Neutral Weak Form Factors of the Proton

    SciTech Connect

    Deur, Alexandre; Fleck, Andre; Saha, Arunava; Gasparian, Ashot; Frois, Bernard; Wojtsekhowski, Bogdan; Vlahovic, Branislav; Perdrisat, Charles; Cavata, Christian; Jutier, Christophe; De Jager, Cornelis; Neyret, Damien; Dale, Daniel; Armstrong, David; Lhuillier, David; Prout, David; Margaziotis, Demetrius; Kim, Donghee; Burtin, Etienne; Chudakov, Eugene; Hersman, F.; Garibaldi, Franco; Marie, Frederic; Miller, Greg; Rutledge, Gary; Gerstner, George; Petratos, Gerassimos; Quemener, Gilles; Cates, Gordon; Thompson, J.; Martino, Jacques; Gomez, Javier; Jorda, Jean-Paul; Hansen, Jens-Ole; Chen, Jian-Ping; Jardillier, Johann; Calarco, John; LeRose, John; Price, John; Gao, Juncai; McIntyre, Justin; McCormick, Kathy; Fissum, Kevin; Kramer, Kevin; Aniol, Konrad; Kumar, Krishna; Wijesooriya, Krishni; Ewell, Lars; Todor, Luminita; Spradlin, Marcus; Jones, Mark; Leuschner, Mark; Epstein, Martin; Baylac, Maud; Holtrop, Maurik; Finn, Michael; Kuss, Michael; Kim, Min; Falletto, Nicolas; Liyanage, Nilanga; Glamazdin, Oleksandr; Rutt, Paul; Souder, Paul; Ulmer, Paul; Mastromarino, Peter; Djawotho, Pibero; Wilson, Richard; Suleiman, Riad; Holmes, Richard; Madey, Richard; Lourie, Robert; Michaels, Robert; Pomatsalyuk, Roman; Gilman, Ronald; Incerti, Sebastien; Escoffier, Stephanie; Pussieux, Thierry; Humensky, Thomas; Gorbenko, Viktor; Punjabi, Vina; Kahl, William; Meziani, Zein-Eddine

    1999-02-01

    We have measured the parity-violating electroweak asymmetry in the elastic scattering of polarized electrons from the proton. The kinematic point [(Thetalab) = 12.3r and (Q2) = 0.48 (GeV/c)2] is chosen to provide sensitivity, at a level that is of theoretical interest, to the strange electric form factor GsE. The result, A = - 14.5 + or - 2.2 ppm, is consistent with the electroweak standard model and no additional contributions from strange quarks. In particular, the measurement implies GsE + 0.39GsM = 0.023 + or - 0.034(stat) + or - 0.022(syst) + or - 0.026(delta-GnE), where the last uncertainty arises from the estimated uncertainty in the neutron electric form factor.

  2. Deuteron electromagnetic form factors with the light-front approach

    NASA Astrophysics Data System (ADS)

    Sun, Bao-dong; Dong, Yu-bing

    2017-01-01

    The electromagnetic form factors and low-energy observables of the deuteron are studied with the help of the light-front approach, where the deuteron is regarded as a weakly bound state of a proton and a neutron. Both the S and D wave interacting vertexes among the deuteron, proton, and neutron are taken into account. Moreover, the regularization functions are also introduced. In our calculations, the vertex and the regularization functions are employed to simulate the momentum distribution inside the deuteron. Our numerical results show that the light-front approach can roughly reproduce the deuteron electromagnetic form factors, like charge G 0, magnetic G 1, and quadrupole G 2, in the low Q 2 region. The important effect of the D wave vertex on G 2 is also addressed. Supported by National Natural Science Foundation of China (10975146, 11475192), The fund provided by the Sino-German CRC 110 “Symmetries and the Emergence of Structure in QCD" project is also appreciated, YBD thanks FAPESP grant 2011/11973-4 for funding his visit to ICTP-SAIFR

  3. Medium modification of the proton form-factor

    SciTech Connect

    Steffen Strauch

    2004-02-01

    I argue that the double ratio of proton-recoil polarization-transfer coefficients, P{prime}{sub x} and P{prime}{sub z}, of the quasielastic {sup 4}He(e,e{prime}p){sup 3}H reaction with respect to the elastic {sup 1}H(e,e{prime}p) reaction is sensitive to possible medium modifications of the proton form factor in {sup 4}He. Recent measurements at both Mainz and Jefferson Lab of this double ratio at four-momentum transfers squared between 0.4 (GeV/c){sup 2} and 2.6 (GeV/c){sup 2} are discussed. I show that the data challenge state-of-the-art conventional meson-nucleon calculations, as these are unable to describe the results. The data hint at the need to include medium modifications of the proton form factor, as predicted by a quark-meson-coupling model, in the calculations. A recently approved follow-up experiment at a Q{sup 2} of 0.8 (GeV/c){sup 2} and 1.3 (GeV/c){sup 2} with unprecedented precision will provide one of the most stringent tests of the applicability of various calculations.

  4. Small form factor optical fiber connector evaluation for harsh environments

    NASA Astrophysics Data System (ADS)

    Ott, Melanie N.; Thomes, W. Joe, Jr.; Chuska, Richard F.; Switzer, Robert; Blair, Diana E.

    2011-09-01

    For the past decade NASA programs have utilized the Diamond AVIM connector for optical fiber assemblies on space flight instrumentation. These connectors have been used in communications, sensing and LIDAR systems where repeatability and high performance are required. Recently Diamond has released a smaller form factor optical fiber connector called the "Mini-AVIM" which although more compact still includes the tight tolerances and the ratcheting feature of the heritage AVIM. NASA Goddard Space Flight Center Photonics Group in the Parts, Packaging and Assembly Technologies Office has been performing evaluations of this connector to determine how it compares to the performance of the AVIM connector and to assess its feasibility for harsh environmental applications. Vibration and thermal testing were performed on the Mini-AVIM with both multi-mode and single-mode optical fiber using insitu optical transmission monitoring. Random vibration testing was performed using typical launch condition profiles for most NASA missions but extended to 35 Grms, which is much higher than most requirements. Thermal testing was performed incrementally up to a range of -55°C to +125°C. The test results include both unjacketed fiber and cabled assembly evaluations. The data presented here indicate that the Mini-AVIM provides a viable option for small form factor applications that require a high performance optical fiber connector.

  5. 'Cherry red spot' in a patient with Tay-Sachs disease: case report.

    PubMed

    Aragão, Ricardo Evangelista Marrocos de; Ramos, Régia Maria Gondim; Pereira, Felipe Bezerra Alves; Bezerra, Andreya Ferreira Rodrigues; Fernandes, Daniel Nogueira

    2009-01-01

    Tay-Sachs disease is an autosomal recessive disorder of sphingolipid metabolism, caused by enzyme hexosaminidase A deficiency that leads to an accumulation of GM2 in neurocytes which results in progressive loss of neurological function. The accumulation of lipid in retinal ganglion cells that leads to a chalk-white appearance of the fundus called 'cherry red spot' is the hallmark of Tay-Sachs disease. It is also seen in others neurometabolic diseases as well as in central retinal artery occlusion. This case reports a child with Tay-Sachs disease in a family with four previous similar deaths without diagnostic.

  6. Approaches to the control and prevention of Tay-Sachs disease.

    PubMed

    Kaback, M M; Zeiger, R S; Reynolds, L W; Sonneborn, M

    1974-01-01

    A prototype Tay-Sachs disease prevention program is presented and di scussed. The program strategy, design, and methodology are reviewed and results and analyses of epidemiologic data, testing results, and in-prog ram evaluations of the testing method are given, along with overall program results. Psychosocial, genetic, and socioeconomic consideration s in the counseling of screenees and relatives of carriers are discussed. In the 1st year of the program, 11 couples, none of whom had previously had a Tay-Sachs child, were identified to be at risk for Tay-Sachs disease in their offspring.

  7. Molecular characterization of a novel HEXA mutation at the +3 position of intron 8 in a Tay-Sachs disease patient

    SciTech Connect

    Richard, M.; Triggs-Raine, B.; Natowicz, M.

    1994-09-01

    Tay-Sachs disease is an autosomal recessive lysosomal storage disorder resulting from mutations in the HEXA gene that cause a deficiency in the activity of that enzyme {beta}-hexosaminidase A (Hex A). This deficiency leads to the build-up of G{sub M2} ganglioside, resulting in neurodegeneration and death. Biochemical analysis of a non-Jewish patient with a late-infantile form of Tay-Sachs disease revealed a substantial level of Hex A activity (38.4%) when 4-MUG was used as the substrate. However, when a substrate (4-MUGS) specific for the {alpha}-subunit of Hex A ({alpha}{beta}) was used, almost no activity was detected in the HEXA gene of the patient using SSCP analysis followed by sequencing. The first mutation, a G533A substitution in exon 5, is previously described and associated with the B1 form of Tay-Sachs disease. The second mutation is a novel a-to-g base change at the +3 position of intron 8. This was confirmed using the AIRS method, whereby a MaeIII site was created in the presence of the mutation. Normal and patient mRNA was reverse transcribed and exons 7 to 9 were PCR-amplified from the cDNA. An abnormally sized amplification product detected only in the patient cDNA was sequenced; exon 8 had been deleted and exons 7 and 9 were spliced together. A substantial level of normally-sized PCR product was also detected in the patient`s cDNA. Experiments are in progress to determine if this is produced from the allele harboring the G533A mutation. Given that previous mutations of this type have been associated with 97-100% abnormal splicing, this mutation is likely to be the cause, together with the G533A mutation, of Tay-Sachs disease in this patient.

  8. Lattice calculation of composite dark matter form factors

    NASA Astrophysics Data System (ADS)

    Appelquist, T.; Brower, R. C.; Buchoff, M. I.; Cheng, M.; Cohen, S. D.; Fleming, G. T.; Kiskis, J.; Lin, M. F.; Neil, E. T.; Osborn, J. C.; Rebbi, C.; Schaich, D.; Schroeder, C.; Syritsyn, S.; Voronov, G.; Vranas, P.; Wasem, J.

    2013-07-01

    Composite dark matter candidates, which can arise from new strongly-coupled sectors, are well-motivated and phenomenologically interesting, particularly in the context of asymmetric generation of the relic density. In this work, we employ lattice calculations to study the electromagnetic form factors of electroweak-neutral dark-matter baryons for a three-color, QCD-like theory with Nf=2 and 6 degenerate fermions in the fundamental representation. We calculate the (connected) charge radius and anomalous magnetic moment, both of which can play a significant role for direct detection of composite dark matter. We find minimal Nf dependence in these quantities. We generate mass-dependent cross sections for dark matter-nucleon interactions and use them in conjunction with experimental results from XENON100, excluding dark matter candidates of this type with masses below 10 TeV.

  9. Exposing strangeness: Projections for kaon electromagnetic form factors

    DOE PAGES

    Gao, Fei; Chang, Lei; Liu, Yu -Xin; ...

    2017-08-28

    A continuum approach to the kaon and pion bound-state problems is used to reveal their electromagnetic structure. For both systems, when used with parton distribution amplitudes appropriate to the scale of the experiment, Standard Model hard-scattering formulas are accurate to within 25% at momentum transfers Q2 ≈ 8 GeV2. There are measurable differences between the distribution of strange and normal matter within the kaons, e.g. the ratio of their separate contributions reaches a peak value of 1.5 at Q2 ≈ 6 GeV2. Its subsequent Q2 evolution is accurately described by the hard scattering formulas. Projections for the ratio of kaonmore » and pion form factors at timelike momenta beyond the resonance region are also presented. In conclusion, these results and projections should prove useful in planning next-generation experiments.« less

  10. The Spectral Form Factor Is Not Self-Averaging

    SciTech Connect

    Prange, R.

    1997-03-01

    The form factor, k(t), is the spectral statistic which best displays nonuniversal quasiclassical deviations from random matrix theory. Recent estimations of k(t) for a single spectrum found interesting new effects of this type. It was supposed that k(t) is {ital self-averaging} and thus did not require an ensemble average. We here argue that this supposition sometimes fails and that for many important systems an ensemble average is essential to see detailed properties of k(t). In other systems, notably the nontrivial zeros of Riemann zeta function, it will be possible to see the nonuniversal properties by an analysis of a single spectrum. {copyright} {ital 1997} {ital The American Physical Society}

  11. Exposing strangeness: Projections for kaon electromagnetic form factors

    NASA Astrophysics Data System (ADS)

    Gao, Fei; Chang, Lei; Liu, Yu-Xin; Roberts, Craig D.; Tandy, Peter C.

    2017-08-01

    A continuum approach to the kaon and pion bound-state problems is used to reveal their electromagnetic structure. For both systems, when used with parton distribution amplitudes appropriate to the scale of the experiment, Standard Model hard-scattering formulas are accurate to within 25% at momentum transfers Q2≈8 GeV2. There are measurable differences between the distribution of strange and normal matter within the kaons, e.g. the ratio of their separate contributions reaches a peak value of 1.5 at Q2≈6 GeV2. Its subsequent Q2 evolution is accurately described by the hard scattering formulas. Projections for the ratio of kaon and pion form factors at timelike momenta beyond the resonance region are also presented. These results and projections should prove useful in planning next-generation experiments.

  12. Meson Form Factors and Deep Exclusive Meson Production Experiments

    NASA Astrophysics Data System (ADS)

    Horn, Tanja

    2017-03-01

    Pion and kaon electroproduction data play a unique role in Nature and our understanding of them is essential for explaining hadron structure. Precision longitudinaltransverse separated pion and kaon cross sections are of particular interest. They allow for the extraction of meson form factors and validation of understanding of hard exclusive and semi-inclusive reactions (π+, K+, π0, γ) towards 3D hadron imaging and potential future flavor decomposition. We review recent data and present prospects for deep exclusive pion and kaon electroproduction at the 12 GeV Jefferson Lab including the prospects to use projected charged- and neutral pion data to further determine the spin, charge-parity and flavor of GPDs, including the helicity-flip GPDs.

  13. PCMCIA-like ultrasmall form-factor optical drive

    NASA Astrophysics Data System (ADS)

    Kim, Sookyung; Lee, Jungkyu; Park, Jinmoo; Park, Gunsoon; Lee, Jeonguk; Lee, Choongwoo; Son, Do-Hyeon; Kim, Jin-Yong; Kim, Seong-hyok; Yee, Youngjoo

    2003-09-01

    A prototype of ultra small optical drive was studied and developed in order to see the feasibility of mobile application, which is targeted to be attachable into the PCMCIA II slot in small mobile devices. A new design and fabrication technology of optical flying head (OFH) for first surface MO recording was studied, and an effective OFH precisely equipped with high NA lens and MO coil was developed based on miniaturization technology. Design consideration of small form factor optical drive is discussed. Some technical issues and barriers in designing and manufacturing the OFH are introduced. Head-disk interface for reliability and flying stability on plastic disk media was tested and evaluated. Basic tracking and read-write performances in a test bed system were tested.

  14. Longitudinal electron scattering form factors for 54,56Fe

    NASA Astrophysics Data System (ADS)

    Salman, A. D.; Kadhim, D. R.

    2014-09-01

    In this paper, inelastic longitudinal electron scattering form factors for C2 transition have been studied in 54Fe and 56Fe with the aid of shell model calculations. The GX1 effective interaction for the fp-shell is used with the nucleon-nucleon realistic interaction Michigan three-range Yukawa and Modified surface delta interaction as a two-body interactions. The core polarization effects is taken into account through the first-order perturbation theory with the effective charge, which is taken to the proton and the neutron. The effective charge along with the core effects up to 6 ℏw enhanced the calculation very well and improving good agreement with the experimental data.

  15. Form factors and related quantities in clothed-particle representation

    NASA Astrophysics Data System (ADS)

    Shebeko, Alexander; Arslanaliev, Adam

    2017-03-01

    We show new applications of the notion of clothed particles in quantum field theory. Its realization by means of the clothing procedure put forward by Greenberg and Schweber allows one to express the total Hamiltonian H and other generators of the Poincaré group for a given system of interacting fields through the creation (annihilation) operators for the so-called clothed particles with physical (observed) properties. Here such a clothed particle representation is used to calculate the matrix elements (shortly, form factors) of the corresponding Nöther current operators sandwiched between the H eigenstates. Our calculations are performed with help of an iterative technique suggested by us earlier when constructing the NN → πNN transition operators. As an illustration, we outline some application of our approach in the spinor quantum electrodynamics.

  16. Thin and small form factor cells : simulated behavior.

    SciTech Connect

    Clews, Peggy Jane; Pluym, Tammy; Grubbs, Robert K.; Cruz-Campa, Jose Luis; Zubia, David; Young, Ralph Watson; Okandan, Murat; Gupta, Vipin P.; Nielson, Gregory N.; Resnick, Paul James

    2010-07-01

    Thin and small form factor cells have been researched lately by several research groups around the world due to possible lower assembly costs and reduced material consumption with higher efficiencies. Given the popularity of these devices, it is important to have detailed information about the behavior of these devices. Simulation of fabrication processes and device performance reveals some of the advantages and behavior of solar cells that are thin and small. Three main effects were studied: the effect of surface recombination on the optimum thickness, efficiency, and current density, the effect of contact distance on the efficiency for thin cells, and lastly the effect of surface recombination on the grams per Watt-peak. Results show that high efficiency can be obtained in thin devices if they are well-passivated and the distance between contacts is short. Furthermore, the ratio of grams per Watt-peak is greatly reduced as the device is thinned.

  17. Algebraic approach to form factors in the complex sinh-Gordon theory

    NASA Astrophysics Data System (ADS)

    Lashkevich, Michael; Pugai, Yaroslav

    2017-01-01

    We study form factors of the quantum complex sinh-Gordon theory in the algebraic approach. In the case of exponential fields the form factors can be obtained from the known form factors of the ZN-symmetric Ising model. The algebraic construction also provides an Ansatz for form factors of descendant operators. We obtain generating functions of such form factors and establish their main properties: the cluster factorization and reflection equations.

  18. Factors Governing Surface Form Accuracy In Diamond Machined Components

    NASA Astrophysics Data System (ADS)

    Myler, J. K.; Page, D. A.

    1988-10-01

    simple spheres. It is important however to realise that a diamond turning process will possess a new set of criteria which limit the accuracy of the surface profile created corresponding to a completely new set of specifications. The most important factors are:- tool centring accuracy, surface waviness, conical form error, and other rotationally symmetric non spherical errors. The fixturing of the workpiece is very different from that of a conventional lap, since in many cases the diamond machine resembles a conventional lathe geometry where the workpiece rotates at a few thousand R.P.M. Substrates must be held rigidly for rotation at such speeds as compared with more delicate mounting methods for conventional laps. Consequently the workpiece may suffer from other forms of deformation which are non-rotationally symmetric due to mounting stresses (static deformation) and stresses induced at the speed of rotation (dynamic deformation). The magnitude of each of these contributions to overall form error will be a function of the type of machine, the material, substrate, and testing design. The following sections describe each of these effects in more detail based on experience obtained on a Pneumo Precision MSG325 XY CNC machine. Certain in-process measurement techniques have been devised to minimise and quantify each contribution.

  19. Tay-Sachs disease: current perspectives from Australia.

    PubMed

    Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Delatycki, Martin B

    2015-01-01

    Tay-Sachs disease (TSD) is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years.

  20. ATYPICAL PRESENTATION OF LATE-ONSET TAY-SACHS DISEASE

    PubMed Central

    DEIK, ANDRES; SAUNDERS-PULLMAN, RACHEL

    2015-01-01

    Introduction Late-onset Tay-Sachs disease (LOTS) is a lysosomal storage disease caused by deficient Beta-hexosaminidase A activity. Methods We describe a 53-year-old woman who presented with adult-onset leg weakness, and whose initial diagnosis was progressive muscular atrophy without identifiable etiology. Development of cerebellar ataxia in mid-life prompted reassessment. Results Beta-hexosaminidase A quantification assay demonstrated absence of the isozyme. Genetic testing identified compound heterozygous mutations in the HEXA gene, confirming the diagnosis of LOTS. Conclusions The phenotypic spectrum of LOTS includes motor neuronopathy, ataxia, choreoathetosis, neuropathy, and psychiatric symptoms in various combinations. This patient highlights the emergence of different clinical features over many years and emphasizes the need to consider LOTS in the differential diagnosis of progressive muscular atrophy. PMID:24327357

  1. Atypical presentation of late-onset Tay-Sachs disease.

    PubMed

    Deik, Andres; Saunders-Pullman, Rachel

    2014-05-01

    Late-onset Tay-Sachs disease (LOTS) is a lysosomal storage disease caused by deficient Beta-hexosaminidase A activity. We describe a 53-year-old woman who presented with adult-onset leg weakness, and whose initial diagnosis was progressive muscular atrophy without identifiable etiology. Development of cerebellar ataxia in mid-life prompted reassessment. Beta-hexosaminidase A quantification assay demonstrated absence of the isozyme. Genetic testing identified compound heterozygous mutations in the HEXA gene, confirming the diagnosis of LOTS. The phenotypic spectrum of LOTS includes motor neuronopathy, ataxia, choreoathetosis, neuropathy, and psychiatric symptoms in various combinations. This patient highlights the emergence of different clinical features over many years and emphasizes the need to consider LOTS in the differential diagnosis of progressive muscular atrophy. Copyright © 2013 Wiley Periodicals, Inc.

  2. Numerical Relativity and the Bondi-Metzner-Sachs Group

    NASA Astrophysics Data System (ADS)

    Winicour, Jeffrey

    2017-01-01

    There are interesting phenomena associated with the Bondi-Metzner-Sachs (BMS) group that deserve numerical exploration. The BMS group, which is the asymptotic symmetry group of an isolated gravitational system, extends the Poincare group by the addition of an infinite set of supertranslations parameterized by a function on the sphere α(θ , ϕ) . The l = 0 and l = 1 spherical harmonics invariantly pick out the time and space translations, which leads to an unambiguous definition of energy and momentum. However, a Poincare subgroup cannot be invariantly defined, which leads to a supertranslation ambiguity in the definition of angular momentum. This opens the possibility of a purely general relativistic mechanism for angular momentum loss. The supertranslations are also associated with the gravitational memory effect. I will discuss these problems which are ripe for the numerical simulation of high spin black hole binaries. Supported by NSF grant PHY-1505965 to the University of Pittsburgh.

  3. Tay-Sachs disease: current perspectives from Australia

    PubMed Central

    Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Delatycki, Martin B

    2015-01-01

    Tay-Sachs disease (TSD) is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years. PMID:25653550

  4. INTEGRATED SACHS-WOLFE IMPRINT OF SUPERSTRUCTURES ON LINEAR SCALES

    SciTech Connect

    Papai, Peter; Szapudi, Istvan; Granett, Benjamin R.

    2011-05-01

    We build a model for the density and integrated Sachs-Wolfe (ISW) profile of supervoid and supercluster structures. Our model assumes that fluctuations evolve linearly from an initial Gaussian random field. We find these assumptions capable of describing N-body simulations and simulated ISW maps remarkably well on large scales. We construct an ISW map based on locations of superstructures identified previously in the Sloan Digital Sky Survey Luminous Red Galaxy sample. A matched filter analysis of the cosmic microwave background confirms a signal at the 3.2{sigma} confidence level and estimates the radius of the underlying structures to be 55 {+-} 28 h{sup -1} Mpc. The amplitude of the signal, however, is 2{sigma} higher than {Lambda}CDM predictions.

  5. Tay-Sach disease with "cherry-red spot"--first reported case in Malaysia.

    PubMed

    Chan, L Y; Balasubramaniam, S; Sunder, R; Jamalia, R; Karunakar, T V N; Alagaratnam, J

    2011-12-01

    We present a rare case of Tay-Sachs disease with retinal 'cherry-red spots' in a 19-month-old Malay child. Molecular genetic studies confirmed the diagnosis. The case highlights that 'cherry-red spot' is a useful clinical clue in Tay-Sachs disease and several other lysosomal storage disorders. It serves as an ideal illustration of the eye as a window to inborn error of metabolism.

  6. Segregation of Tay-Sachs and Sandhoff alleles in a non-Jewish family.

    PubMed Central

    Lane, A B; Young, E; Jenkins, T

    1980-01-01

    A non-Jewish family is presented in which the genes for Tay-Sachs disease and Sandhoff disease are segregating. Individuals heterozygous for both alleles have low serum and white cell total hexosaminidase levels together with a proportion of heat-labile hexosaminidase A (HEX A) which falls in the normal range. The individuals would not be detected as carriers of Tay-Sachs disease or Sandhoff disease in a population screening program. PMID:7446530

  7. Gauge-invariant treatment of the integrated Sachs-Wolfe effect on general spherically symmetric spacetimes

    SciTech Connect

    Tomita, Kenji

    2010-03-15

    On the basis of the Gerlach-Sengupta theory of gauge-invariant perturbations, a formula of the integrated Sachs-Wolfe effect for a central observer is derived on general spherically symmetric spacetimes. It will be useful for comparative studies of theoretical and observational aspects of the integrated Sachs-Wolfe effect in the Lemaitre-Tolman-Bondi cosmological models which have been noticed by explaining the apparent acceleration without cosmological constant.

  8. Crystal Structure of Human [Beta]-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    SciTech Connect

    Mark, Brian L.; Mahuran, Don J.; Cherney, Maia M.; Zhao, Dalian; Knapp, Spencer; James, Michael N.G.

    2010-12-01

    In humans, two major {beta}-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits {alpha} and {beta} (60% identity), whereas Hex B is a homodimer of {beta}-subunits. Interest in human {beta}-hexosaminidase stems from its association with Tay-Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of G{sub M2}-ganglioside (G{sub M2}). Hex A degrades G{sub M2} by removing a terminal N-acetyl-D-galactosamine ({beta}-GalNAc) residue, and this activity requires the G{sub M2}-activator, a protein which solubilizes the ganglioside for presentation to Hex A. We present here the crystal structure of human Hex B, alone (2.4 {angstrom}) and in complex with the mechanistic inhibitors GalNAc-isofagomine (2.2 {angstrom}) or NAG-thiazoline (2.5 {angstrom}). From these, and the known X-ray structure of the G{sub M2}-activator, we have modeled Hex A in complex with the activator and ganglioside. Together, our crystallographic and modeling data demonstrate how {alpha} and {beta}-subunits dimerize to form either Hex A or Hex B, how these isoenzymes hydrolyze diverse substrates, and how many documented point mutations cause Sandhoff disease ({beta}-subunit mutations) and Tay-Sachs disease ({alpha}-subunit mutations).

  9. Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay–Sachs Disease

    PubMed Central

    Mark, Brian L.; Mahuran, Don J.; Cherney, Maia M.; Zhao, Dalian; Knapp, Spencer; James, Michael N. G.

    2010-01-01

    In humans, two major β-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits α and β (60% identity), whereas Hex B is a homodimer of β-subunits. Interest in human β-hexosaminidase stems from its association with Tay–Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of GM2-ganglioside (GM2). Hex A degrades GM2 by removing a terminal N-acetyl-D-galactosamine (β-GalNAc) residue, and this activity requires the GM2–activator, a protein which solubilizes the ganglioside for presentation to Hex A. We present here the crystal structure of human Hex B, alone (2.4 Å) and in complex with the mechanistic inhibitors GalNAc-isofagomine (2.2 Å) or NAG-thiazoline (2.5 Å). From these, and the known X-ray structure of the GM2–activator, we have modeled Hex A in complex with the activator and ganglioside. Together, our crystallographic and modeling data demonstrate how α and β-subunits dimerize to form either Hex A or Hex B, how these isoenzymes hydrolyze diverse substrates, and how many documented point mutations cause Sandhoff disease (β-subunit mutations) and Tay–Sachs disease (α-subunit mutations). PMID:12662933

  10. Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.

    PubMed

    Mark, Brian L; Mahuran, Don J; Cherney, Maia M; Zhao, Dalian; Knapp, Spencer; James, Michael N G

    2003-04-11

    In humans, two major beta-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits alpha and beta (60% identity), whereas Hex B is a homodimer of beta-subunits. Interest in human beta-hexosaminidase stems from its association with Tay-Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of G(M2)-ganglioside (G(M2)). Hex A degrades G(M2) by removing a terminal N-acetyl-D-galactosamine (beta-GalNAc) residue, and this activity requires the G(M2)-activator, a protein which solubilizes the ganglioside for presentation to Hex A. We present here the crystal structure of human Hex B, alone (2.4A) and in complex with the mechanistic inhibitors GalNAc-isofagomine (2.2A) or NAG-thiazoline (2.5A). From these, and the known X-ray structure of the G(M2)-activator, we have modeled Hex A in complex with the activator and ganglioside. Together, our crystallographic and modeling data demonstrate how alpha and beta-subunits dimerize to form either Hex A or Hex B, how these isoenzymes hydrolyze diverse substrates, and how many documented point mutations cause Sandhoff disease (beta-subunit mutations) and Tay-Sachs disease (alpha-subunit mutations).

  11. Dressed Quark Mass Dependence of Pion and Kaon Form Factors

    SciTech Connect

    Ninomiya, Y.; Bentz, W.; Cloet, I. C.

    2015-02-04

    The structure of hadrons is described well by the Nambu-Jona-Lasinio (NJL) model, which is a chiral effective quark theory of QCD. In this work we explore the electromagnetic structure of the pion and kaon using the three-flavor NJL model in the proper-time regularization scheme, including effects of the pion cloud at the quark level. In the calculation there is only one free parameter, which we take as the dressed light quark (u and d) mass. In the regime where the dressed light quark mass is approximately 0.25 GeV we find that the calculated values of the kaon decay constant, current quark masses, and quark condensates are consistent with experiment- and QCD-based analyses. We also investigate the dressed light quark mass dependence of the pion and kaon electromagnetic form factors, where comparison with empirical data and QCD predictions also favors a dressed light quark mass near 0.25 GeV.

  12. B meson semileptonic form factors from unquenched lattice QCD

    SciTech Connect

    Gulez, Emel; Gray, Alan; Shigemitsu, Junko; Wingate, Matthew; Davies, Christine T. H.; Lepage, G. Peter

    2006-04-01

    The semileptonic process, B{yields}{pi}l{nu}, is studied via full QCD lattice simulations. We use unquenched gauge configurations generated by the MILC Collaboration. These include the effect of vacuum polarization from three quark flavors: the s quark and two very light flavors (u/d) of variable mass allowing extrapolations to the physical chiral limit. We employ nonrelativistic QCD to simulate the b quark and a highly improved staggered quark action for the light sea and valence quarks. We calculate the form factors f{sub +}(q{sup 2}) and f{sub 0}(q{sup 2}) in the chiral limit for the range 16 GeV{sup 2}{<=}q{sup 2}

  13. Nucleon form factors and hidden symmetry in holographic QCD

    SciTech Connect

    Hong, Deog Ki; Rho, Mannque; Yee, Ho-Ung; Yi, Piljin

    2008-01-01

    The vector dominance of the electromagnetic form factors both for mesons and baryons arises naturally in holographic QCD, where both the number of colors and the 't Hooft coupling are taken to be very large, offering a bona-fide derivation of the notion of vector dominance. The crucial ingredient for this is the infinite tower of vector mesons in the approximations made which share features that are characteristic of the quenched approximation in lattice QCD. We approximate the infinite sum by contributions from the lowest four vector mesons of the tower which turn out to saturate the charge and magnetic moment sum rules within a few percent and compute them totally free of unknown parameters for momentum transfers Q{sup 2} < or approx. 1 GeV{sup 2}. We identify certain observables that can be reliably computed within the approximations and others that are not, and discuss how the improvement of the latter can enable one to bring holographic QCD closer to QCD proper.

  14. Scrambling the spectral form factor: Unitarity constraints and exact results

    NASA Astrophysics Data System (ADS)

    del Campo, A.; Molina-Vilaplana, J.; Sonner, J.

    2017-06-01

    Quantum speed limits set an upper bound to the rate at which a quantum system can evolve, and as such can be used to analyze the scrambling of information. To this end, we consider the survival probability of a thermofield double state under unitary time evolution which is related to the analytic continuation of the partition function. We provide an exponential lower bound to the survival probability with a rate governed by the inverse of the energy fluctuations of the initial state. Further, we elucidate universal features of the nonexponential behavior at short and long times of evolution that follow from the analytic properties of the survival probability and its Fourier transform, both for systems with a continuous and for systems with a discrete energy spectrum. We find the spectral form factor in a number of illustrative models; notably, we obtain the exact answer in the Gaussian unitary ensemble for any N with excellent agreement with recent numerical studies. We also discuss the relationship of our findings to models of black hole information loss, such as the Sachdev-Ye-Kitaev model dual to AdS2 , as well as higher-dimensional versions of AdS/CFT.

  15. The Magnetic Form Factor of the Neutron, G

    NASA Astrophysics Data System (ADS)

    Markowitz, Pete Edward Christopher

    We measured the d(e,e^' n)p cross-section at three values of Q^2 : 0.255, 0.176 and 0.109 (GeV/c)^2 . The electrons were detected with the OHIPS magnetic spectrometer, and the neutrons were detected in a liquid mineral oil scintillator array. The measurement were made at a fixed neutron angle of theta_ {n} = 57^circ; the Q^2 values were obtained by varying the incident electron energy and the scattering angle. These cross sections are sensitive primarily to the neutron magnetic form factor at these quasifree kinematics. The efficiency of the neutron detector was determined by the associated particle technique with the d(gamma ,pn) reaction for each of the three neutron kinetic energies. The value of G_sp{M} {n} extracted from the cross sections are consistent with the dipole parametrization at the two higher momentum transfers; at the lowest momentum transfer the value of G_sp{M}{n} is 10% higher than the dipole model. This enhancement at low momentum transfer is consistent with previous measurements.

  16. A human factors approach to waste form design

    SciTech Connect

    Rodriguez, M.A.

    1994-04-01

    The current study consist of two experiments and an example of a revised waste form to demonstrate the necessity of careful form design and provide guidance in obtaining accurate information through written solicitation of any kind. In Experiment 1, two differently designed forms were used to solicit the same list of specific information. The data suggest that the more clearly designed form significantly produced more of the specific information required than the form that just listed the questions. Experiment 2, which is to be conducted during the spring semester 1994, is designed to address three specific aspects of form design. The results of this Experiment 2 will be interpreted and presented at the 1994 International High-Level Radioactive Waste Management Conference, May 22--26. Guidelines and examples of form design are given.

  17. Nucleon Structure and Hyperon Form Factors from Lattice QCD.

    SciTech Connect

    Lin,H.W.

    2007-06-11

    In this work, I report the latest lattice QCD calculations of nucleon and hyperon structure from chiral fermions in 2+1-flavor dynamical simulations. All calculations are done with a chirally symmetric fermion action, domain-wall fermions, for valence quarks. I begin with the latest lattice results on the nucleon structure, focusing on results from RBC/UKQCD using 2+1-flavor chiral fermion actions. We find the chiral-extrapolated axial coupling constant at physical pion mass point. to be 1.23(5), consistent with experimental value. The renormalization constants for the structure functions are obtained from RI/MOM-scheme non-perturbative renormalization. We find first moments of the polarized and unpolarized nucleon structure functions at zero transfer momentum to be 0.133(13) and 0.203(23) respectively, using continuum chiral extrapolation. These are consistent with the experimental values, unlike previous calculations which have been 50% larger. We also have a prediction for the transversity, which we find to be 0.56(4). The twist-3 matrix element is consistent with zero which agrees with the prediction of the Wandzura-Wilczek relation. In the second half of this work, I report an indirect dynamical estimation of the strangeness proton magnetic moments using mixed actions. With the analysis of hyperon form factors and using charge symmetry, the strangeness of proton is found to be -0.066(2G), consistent with the Adelaide-JLab Collaboration's result. The hyperon {Sigma} and {Xi} axial coupling constants are also performed for the first time in a lattice calculation, g{sub {Sigma}{Sigma}} = 0.441(14) and g{sub {Xi}{Xi}} = -0.277(11).

  18. Nucleon Structure and hyperon form factors from lattice QCD

    SciTech Connect

    Lin, Huey-Wen

    2007-06-11

    In this work, I report the latest lattice QCD calculations of nucleon and hyperon structure from chiral fermions in 2+1-flavor dynamical simulations. All calculations are done with a chirally symmetric fermion action, domain-wall fermions, for valence quarks. I begin with the latest lattice results on the nucleon structure, focusing on results from RBC/UKQCD using 2+1-flavor chiral fermion actions. We find the chiral-extrapolated axial coupling constant at physical pion mass point to be 1.23(5), consistant with experimental value. The renormalization constants for the structure functions are obtained from RI/MOM-scheme non-perturbative renormalization. We find first moments of the polarized and unpolarized nucleon structure functions at zero transfer momentum to be 0.133(13) and 0.203(23) respectively, using continuum chiral extrapolation. These are consistent with the experimental values, unlike previous calculations which have been 50% larger. We also have a prediction for the transversity, which we find to be 0.56(4). The twist-3 matrix element is consistent with zero which agrees with the prediction of the Wandzura-Wilczek relation. In the second half of this work, I report an indirect dynamical estimation of the strangeness proton magnetic moments using mixed actions. With the analysis of hyperon form factors and using charge symmetry, the strangeness of proton is found to be -0.066(26), consistent with the Adelaide-JLab Collaboration's result. The hyperon Sigma and Xi axial coupling constants are also performed for the first time in a lattice calculation, g_SigmaSigma = 0.441(14) and g_XiXi = -0.277(11).

  19. Correlation between Bankart and Hill-Sachs lesions in anterior shoulder dislocation.

    PubMed

    Widjaja, Audi B; Tran, Anh; Bailey, Michael; Proper, Stewart

    2006-06-01

    Bankart lesions and Hill-Sachs lesions are commonly associated with anterior shoulder dislocations. The presence of Bankart lesion indicates the need for surgical repair. Magnetic resonance imaging (MRI) has been shown to be sensitive in detecting these two lesions. The aim of this study is to investigate the correlation between Bankart lesions and Hill-Sachs lesions on MRI for patients with traumatic anterior shoulder dislocations. Between 2003 and 2005, 61 patients from Alfred and Sandringham Hospitals had an MRI as part of the investigation for traumatic anterior shoulder dislocations. The MRI scans were reviewed and subsequently confirmed by a radiologist to show the presence or absence of Bankart and Hill-Sachs lesions. The data were then analysed by a statistician. Although patients with one of these lesions were more than two-and-a-half times as likely to have the other, small study numbers precluded this result from achieving statistical significance. (odds ratio, 2.67 (0.83-8.61), P = 0.10). Younger age was a strong predictor of a recurrence of shoulder dislocation (odds ratio, 0.93 (0.89-0.98), P = 0.005). The presence of Bankart or Hill-Sachs lesions on MRI for the primary shoulder dislocation group was similar to the recurrent group (73% vs. 72% for Bankart lesion and 67% vs. 70% for Hill-Sachs lesion). There is a strong correlation between both lesions. This apparent trend can be useful in predicting the presence of a Bankart lesion when a Hill-Sachs lesion is identified on a plain radiograph. This study suggests the consideration of surgical repair after identification of a Hill-Sachs lesion on plain radiographs, especially for younger patients where the rate of re-dislocation is high.

  20. Next-to-leading-order correction to pion form factor in k{sub T} factorization

    SciTech Connect

    Li Hsiangnan; Shen Yuelong; Wang Yuming; Zou Hao

    2011-03-01

    We calculate the next-to-leading-order (NLO) correction to the pion electromagnetic form factor at leading twist in the k{sub T} factorization theorem. Partons off-shell by k{sub T}{sup 2} are considered in both quark diagrams and effective diagrams for the transverse-momentum-dependent pion wave function. The light-cone singularities in the transverse-momentum-dependent pion wave function are regularized by rotating the Wilson lines away from the light cone. The soft divergences from gluon exchanges among initial- and fal-state partons cancel exactly. We derive the infrared-finite k{sub T}-dependent NLO hard kernel for the pion electromagnetic form factor by taking the difference of the above two sets of diagrams. Varying the renormalization and factorization scales, we find that the NLO correction is smaller, when both the scales are set to the invariant masses of internal particles: it becomes lower than 40% of the leading-order contribution for momentum transfer squared Q{sup 2}>7 GeV{sup 2}. It is observed that the NLO leading-twist correction does not play an essential role in explaining the experimental data, but the leading-order higher-twist contribution does.

  1. Evaluation of a Tay-Sachs disease screening program.

    PubMed

    Gason, A A; Sheffield, E; Bankier, A; Aitken, M A; Metcalfe, S; Barlow Stewart, K; Delatycki, M B

    2003-05-01

    Tay-Sachs Disease (TSD) is an autosomal recessive neurodegenerative disorder. TSD is prevalent in the Ashkenazi Jewish population, and carrier screening programs have been implemented worldwide in these communities. A screening program initiated in 1997 involving the Melbourne Jewish community (Australia) incorporated education, counselling and carrier testing of high-school students aged 15 to 18 years. This study aimed to assess the participation rates, level of knowledge obtained and predicted feelings and attitudes of the students involved. Seven hundred and ten students participated, there was a 67% uptake for testing with a carrier rate of 1 in 28 determined. The level of knowledge of the students following education was high and of relative importance in regard to decision making, as were their feelings and attitudes about genetic testing for carrier status. A significant impediment to test uptake was the need for blood sampling, resulting in a recommendation for the introduction of DNA analysis on cheek brush samples. The evaluation of this program has given a wider scope for further development as well as providing valuable information for the implementation of community screening programs.

  2. Kantowski-Sachs Einstein-æther perfect fluid models

    NASA Astrophysics Data System (ADS)

    Latta, Joey; Leon, Genly; Paliathanasis, Andronikos

    2016-11-01

    We investigate Kantowski-Sachs models in Einstein-æ ther theory with a perfect fluid source using the singularity analysis to prove the integrability of the field equations and dynamical system tools to study the evolution. We find an inflationary source at early times, and an inflationary sink at late times, for a wide region in the parameter space. The results by A.A. Coley, G. Leon, P. Sandin and J. Latta (JCAP 12 (2015) 010), are then re-obtained as particular cases. Additionally, we select other values for the non-GR parameters which are consistent with current constraints, getting a very rich phenomenology. In particular, we find solutions with infinite shear, zero curvature, and infinite matter energy density in comparison with the Hubble scalar. We also have stiff-like future attractors, anisotropic late-time attractors, or both, in some special cases. Such results are developed analytically, and then verified by numerics. Finally, the physical interpretation of the new critical points is discussed.

  3. Reconstructing the integrated Sachs-Wolfe map with galaxy surveys

    NASA Astrophysics Data System (ADS)

    Muir, Jessica; Huterer, Dragan

    2016-08-01

    The integrated Sachs-Wolfe (ISW) effect is a large-angle modulation of the cosmic microwave background (CMB), generated when CMB photons traverse evolving potential wells associated with large scale structure (LSS). Recent efforts have been made to reconstruct maps of the ISW signal using information from surveys of galaxies and other LSS tracers, but investigation into how survey systematics affect their reliability has so far been limited. Using simulated ISW and LSS maps, we study the impact of galaxy survey properties and systematic errors on the accuracy of a reconstructed ISW signal. We find that systematics that affect the observed distribution of galaxies along the line of sight, such as photo-z and bias-evolution related errors, have a relatively minor impact on reconstruction quality. In contrast, however, we find that direction-dependent calibration errors can be very harmful. Specifically, we find that, in order to avoid significant degradation of our reconstruction quality statistics, direction-dependent number density fluctuations due to systematics must be controlled so that their variance is smaller than 10-6 (which corresponds to a 0.1% calibration). Additionally, we explore the implications of our results for attempts to use reconstructed ISW maps to shed light on the origin of large-angle CMB alignments. We find that there is only a weak correlation between the true and reconstructed angular momentum dispersion, which quantifies alignment, even for reconstructed ISW maps which are fairly accurate overall.

  4. Conserved charges of the extended Bondi-Metzner-Sachs algebra

    NASA Astrophysics Data System (ADS)

    Flanagan, Éanna É.; Nichols, David A.

    2017-02-01

    Isolated objects in asymptotically flat spacetimes in general relativity are characterized by their conserved charges associated with the Bondi-Metzner-Sachs (BMS) group. These charges include total energy, linear momentum, intrinsic angular momentum and center-of-mass location, and, in addition, an infinite number of supermomentum charges associated with supertranslations. Recently, it has been suggested that the BMS symmetry algebra should be enlarged to include an infinite number of additional symmetries known as super-rotations. We show that the corresponding charges are finite and well defined, and can be divided into electric parity "super center-of-mass" charges and magnetic parity "superspin" charges. The supermomentum charges are associated with ordinary gravitational-wave memory, and the super center-of-mass charges are associated with total (ordinary plus null) gravitational-wave memory, in the terminology of Bieri and Garfinkle. Superspin charges are associated with the ordinary piece of spin memory. Some of these charges can give rise to black hole hair, as described by Strominger and Zhiboedov. We clarify how this hair evades the no-hair theorems.

  5. The integrated Sachs-Wolfe signal from BOSS superstructures

    NASA Astrophysics Data System (ADS)

    Granett, B. R.; Kovács, A.; Hawken, A. J.

    2015-12-01

    Cosmic structures leave an imprint on the microwave background radiation through the integrated Sachs-Wolfe (ISW) effect. We construct a template map of the linear signal using the Sloan Digital Sky Survey-III Baryon Acoustic Oscillation Survey at redshift 0.43 < z < 0.65. We verify the imprint of this map on the Planck cosmic microwave background (CMB) temperature map at the 97 per cent confidence level and show consistency with the density-temperature cross-correlation measurement. Using this ISW reconstruction as a template, we investigate the presence of ISW sources and further examine the properties of the Granett-Neyrinck-Szapudi supervoid and supercluster catalogue. We characterize the three-dimensional density profiles of these structures for the first time and demonstrate that they are significant structures. Model fits demonstrate that the supervoids are elongated along the line of sight and we suggest that this special orientation may be picked out by the void-finding algorithm in photometric redshift space. We measure the mean temperature profiles in Planck maps from public void and cluster catalogues. In an attempt to maximize the stacked ISW signal, we construct a new catalogue of superstructures based upon local peaks and troughs of the gravitational potential. However, we do not find a significant correlation between these structures and the CMB temperature.

  6. Integrated Sachs-Wolfe effect in time varying vacuum model

    SciTech Connect

    Wang, Y. T.; Gui, Y. X.; Xu, L. X.; Lu, J. B.

    2010-04-15

    The integrated Sachs-Wolfe (ISW) effect is an important implication for dark energy. In this paper, we have calculated the power spectrum of the ISW effect in the time varying vacuum cosmological model, where the model parameter {beta}=4.407 is obtained by the observational constraint of the growth rate. It is found that the source of the ISW effect is not only affected by the different evolutions of the Hubble function H(a) and the dimensionless matter density {Omega}{sub m}(a), but also by the different growth function D{sub +}(a), all of which are changed due to the presence of a matter production term in the time varying vacuum model. However, the difference of the ISW effect in the {Lambda}(t)CDM model and the {Lambda}CDM model is lessened to a certain extent because of the integration from the time of last scattering to the present. It is implied that the observations of the galaxies with high redshift are required to distinguish the two models.

  7. An inducible mouse model of late onset Tay-Sachs disease.

    PubMed

    Jeyakumar, Mylvaganam; Smith, David; Eliott-Smith, Elena; Cortina-Borja, Mario; Reinkensmeier, Gabriele; Butters, Terry D; Lemm, Thorsten; Sandhoff, Konrad; Perry, V Hugh; Dwek, Raymond A; Platt, Frances M

    2002-08-01

    Mouse models of the G(M2) gangliosidoses, Tay-Sachs and Sandhoff disease, are null for the hexosaminidase alpha and beta subunits respectively. The Sandhoff (Hexb-/-) mouse has severe neurological disease and mimics the human infantile onset variant. However, the Tay-Sachs (Hexa-/-) mouse model lacks an overt phenotype as mice can partially bypass the blocked catabolic pathway and escape disease. We have investigated whether a subset of Tay-Sachs mice develop late onset disease. We have found that approximately 65% of the mice develop one or more clinical signs of the disease within their natural life span (n = 52, P < 0.0001). However, 100% of female mice with repeat breeding histories developed late onset disease at an earlier age (n = 21, P < 0.0001) and displayed all clinical features. Repeat breeding of a large cohort of female Tay-Sachs mice confirmed that pregnancy induces late onset Tay-Sachs disease. Onset of symptoms correlated with reduced up-regulation of hexosaminidase B, a component of the bypass pathway.

  8. Effective gene therapy in an authentic model of Tay-Sachs-related diseases.

    PubMed

    Cachón-González, M Begoña; Wang, Susan Z; Lynch, Andrew; Ziegler, Robin; Cheng, Seng H; Cox, Timothy M

    2006-07-05

    Tay-Sachs disease is a prototypic neurodegenerative disease. Lysosomal storage of GM2 ganglioside in Tay-Sachs and the related disorder, Sandhoff disease, is caused by deficiency of beta-hexosaminidase A, a heterodimeric protein. Tay-Sachs-related diseases (GM2 gangliosidoses) are incurable, but gene therapy has the potential for widespread correction of the underlying lysosomal defect by means of the secretion-recapture cellular pathway for enzymatic complementation. Sandhoff mice, lacking the beta-subunit of hexosaminidase, manifest many signs of classical human Tay-Sachs disease and, with an acute course, die before 20 weeks of age. We treated Sandhoff mice by stereotaxic intracranial inoculation of recombinant adeno-associated viral vectors encoding the complementing human beta-hexosaminidase alpha and beta subunit genes and elements, including an HIV tat sequence, to enhance protein expression and distribution. Animals survived for >1 year with sustained, widespread, and abundant enzyme delivery in the nervous system. Onset of the disease was delayed with preservation of motor function; inflammation and GM2 ganglioside storage in the brain and spinal cord was reduced. Gene delivery of beta-hexosaminidase A by using adeno-associated viral vectors has realistic potential for treating the human Tay-Sachs-related diseases.

  9. Basic versus applied research: Julius Sachs (1832–1897) and the experimental physiology of plants

    PubMed Central

    Kutschera, Ulrich

    2015-01-01

    The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This “plant-microbe-view” of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845–1920), so that the term “Sachs-Pfeffer-Principle of Experimental Plant Research” appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria). PMID:26146794

  10. Effective gene therapy in an authentic model of Tay-Sachs-related diseases

    PubMed Central

    Cachón-González, M. Begoña; Wang, Susan Z.; Lynch, Andrew; Ziegler, Robin; Cheng, Seng H.; Cox, Timothy M.

    2006-01-01

    Tay-Sachs disease is a prototypic neurodegenerative disease. Lysosomal storage of GM2 ganglioside in Tay-Sachs and the related disorder, Sandhoff disease, is caused by deficiency of β-hexosaminidase A, a heterodimeric protein. Tay-Sachs-related diseases (GM2 gangliosidoses) are incurable, but gene therapy has the potential for widespread correction of the underlying lysosomal defect by means of the secretion-recapture cellular pathway for enzymatic complementation. Sandhoff mice, lacking the β-subunit of hexosaminidase, manifest many signs of classical human Tay-Sachs disease and, with an acute course, die before 20 weeks of age. We treated Sandhoff mice by stereotaxic intracranial inoculation of recombinant adeno-associated viral vectors encoding the complementing human β-hexosaminidase α and β subunit genes and elements, including an HIV tat sequence, to enhance protein expression and distribution. Animals survived for >1 year with sustained, widespread, and abundant enzyme delivery in the nervous system. Onset of the disease was delayed with preservation of motor function; inflammation and GM2 ganglioside storage in the brain and spinal cord was reduced. Gene delivery of β-hexosaminidase A by using adeno-associated viral vectors has realistic potential for treating the human Tay-Sachs-related diseases. PMID:16801539

  11. Basic versus applied research: Julius Sachs (1832-1897) and the experimental physiology of plants.

    PubMed

    Kutschera, Ulrich

    2015-01-01

    The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This "plant-microbe-view" of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845-1920), so that the term "Sachs-Pfeffer-Principle of Experimental Plant Research" appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria).

  12. Iso-vector form factors of the delta and nucleon in QCD sum rules

    SciTech Connect

    Ozpineci, A.

    2012-10-23

    Form factors are important non-perturbative properties of hadrons. They give information about the internal structure of the hadrons. In this work, iso-vector axial-vector and iso-vector tensor form factors of the nucleon and the iso-vector axial-vector {Delta}{yields}N transition form factor calculations in QCD Sum Rules are presented.

  13. Balloon humeroplasty reconstruction for acute Hill-Sachs injury: A technical note.

    PubMed

    Jacquot, F; Zbili, D; Feron, J-M; Sautet, A; Doursounian, L; Masquelet, A-C

    2016-09-01

    Posterior Hill-Sachs humeral defects are present in 80% to 100% of cases of anterior shoulder dislocation and are a factor in recurrent instability. Several techniques have been described to fill the defect and avoid recurrence. We developed a percutaneous technique to fill the newly created defect in which a percutaneous balloon, analogous to the one used in vertebral kyphoplasty, is used to reduce the defect, which is then filled with calcium phosphate cement. One patient with an acute anterior dislocation of the shoulder with no previous history was treated using this method. Early imaging results showed adequate reduction of the defect and no cement resorption. The patient was followed for 12 months; he had normal function of the shoulder and no recurrent dislocation. Shoulder computed tomography (CT) arthrography with contrast after 3 months showed an intact capsule and no recurrence of the defect. While this technique is certainly in its infancy, we have demonstrated that emergency reduction of the defect in acute first occurrence anterior shoulder dislocation is feasible, helps to restore normal anatomy of the humeral head and leads to good clinical results. Whether it can improve clinical results and prevent recurrent shoulder dislocation remains to be evaluated. Copyright © 2016 SFCM. Published by Elsevier Masson SAS. All rights reserved.

  14. Bs → f0(980) Transition Form Factors Within the kT Factorization Approach

    NASA Astrophysics Data System (ADS)

    Zeng, Dai-Min; Fang, Zhen-Yun

    2013-04-01

    In the paper, we apply the kT factorization approach to deal with the Bs → f0 (980) transition form factors in the large recoil regions, i.e. the small q2 regions. For the purpose, we adopt the B-meson wave-functions ΦB, and δ that include the three-Fock states contributions to do our discussion. Although the scalar meson f0(980) is widely perceived as the 4-quark bound state (scenario 2), but the distribution amplitudes of 4-quark states are still unknown to us, so we adopt 2-quark model (scenario 1) for scalar meson f0(980) in our discussion. By varying the B-meson wave-function parameters within their reasonable regions, we obtain F0(0) = F+(0) = 0.20 ± 0.02, FT(0) = 0.24 ± 0.02. Our present results for these form factors are consistent with the light-cone sum rule results obtained in the literature.

  15. Box products in nilpotent normal form theory: The factoring method

    NASA Astrophysics Data System (ADS)

    Murdock, James

    2016-01-01

    Let N be a nilpotent matrix and consider vector fields x ˙ = Nx + v (x) in normal form. Then v is equivariant under the flow eN*t for the inner product normal form or eMt for the sl2 normal form. These vector equivariants can be found by finding the scalar invariants for the Jordan blocks in N* or M; taking the box product of these to obtain the invariants for N* or M itself; and then boosting the invariants to equivariants by another box product. These methods, developed by Murdock and Sanders in 2007, are here given a self-contained exposition with new foundations and new algorithms yielding improved (simpler) Stanley decompositions for the invariants and equivariants. Ideas used include transvectants (from classical invariant theory), Stanley decompositions (from commutative algebra), and integer cones (from integer programming). This approach can be extended to covariants of sl2k for k > 1, known as SLOCC in quantum computing.

  16. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    PubMed

    Kodama, Takashi; Togawa, Tadayasu; Tsukimura, Takahiro; Kawashima, Ikuo; Matsuoka, Kazuhiko; Kitakaze, Keisuke; Tsuji, Daisuke; Itoh, Kohji; Ishida, Yo-Ichi; Suzuki, Minoru; Suzuki, Toshihiro; Sakuraba, Hitoshi

    2011-01-01

    To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.

  17. Proton MR spectroscopy in three children with Tay-Sachs disease.

    PubMed

    Aydin, Kubilay; Bakir, Baris; Tatli, Burak; Terzibasioglu, Ege; Ozmen, Meral

    2005-11-01

    Tay-Sachs disease is an inherited metabolic disease caused by the accumulation of GM(2) gangliosides in the central nervous system. Deficiency of hexosaminidase A leads to the accumulation of gangliosides in neurons, axons and glial cells. To present the cranial MRI and proton MR spectroscopy findings of children of Tay-Sachs disease. Three children aged 10, 20 and 21 months were examined. On T2-weighted MR images there were hyperintense signal changes in the basal ganglia and cerebral white matter. MR spectroscopy demonstrated an increase in myoinositol/creatine and choline/creatine ratios with a decrease in the N-acetyl aspartate/creatine ratio. The spectroscopy findings support demyelination, gliosis and neuronal loss in the neuropathological process of Tay-Sachs disease.

  18. Arthroscopic Remplissage for Engaging Hill-Sachs Lesions in Patients With Anterior Shoulder Instability

    PubMed Central

    Camp, Christopher L.; Dahm, Diane L.; Krych, Aaron J.

    2015-01-01

    Anterior shoulder instability is often accompanied by a Hill-Sachs defect on the humeral head that can contribute to recurrent instability if not addressed at the time of surgery. We describe a method of performing arthroscopic remplissage to treat engaging Hill-Sachs lesions in patients with glenohumeral instability. It has the benefits of being an efficient procedure that can be performed with minimal technical difficulty and can be used to augment other stabilization procedures such as labral repair. The indications for this technique include the presence of an engaging Hill-Sachs defect in patients will little or no glenoid bone loss. In appropriately selected patients, arthroscopic remplissage has shown reduced rates of recurrent instability. PMID:26697311

  19. Tay-Sachs screening: motives for participating and knowledge of genetics and probability.

    PubMed Central

    Childs, B; Gordis, L; Kaback, M M; Kazazian, H H

    1976-01-01

    A highly-educated, socially aware group of persons presented themselves for Tay-Sachs screening having learned about it mainly from friends, newspapers, radio, and television but not from physicians or rabbis. After learning that screening was possible and deciding that it is in principle a good idea, and after discussing it with relatives and friends but not with physicians and rabbis, they presented themselves for the test. Although the participants knew that Tay-Sachs is a serious disease and that Jews are vulnerable, few of them knew much about the genetics of the disease, its frequency, or the incidence of the carrier state. This experience of screening for Tay-Sachs carriers suggests the need for physicians to learn the relation of genetics to preventive medicine, and for the public to learn more about the biology of man. PMID:1008060

  20. Knowledge and attitudes toward Tay-Sachs disease among a college student population.

    PubMed Central

    Austein, C. F.; Seashore, M. R.; Mick, S. S.

    1981-01-01

    To assess the feasibility of screening the single Jewish population for Tay-Sachs disease (TSD), a questionnaire examining the knowledge of and attitudes toward TSD and genetic screening was sent to 348 Yale University Jewish undergraduates. Of those students responding (63 percent), 78 percent were able to answer general genetic questions correctly while only 1.9 percent could answer specific Tay-Sachs questions correctly. A majority of the students (93.9 percent) indicated some concern about being a carrier for TSD, believed that carrier status would affect future social and reproductive behavior, and expressed an interest in having TS carrier status determined while still single (77.4 percent). Strong correlations were found between knowledge and attitudes, but no significant differences appeared between male and female respondents. In addition to leading to improvements in Tay-Sachs screening programs, the observations have led to suggestions that may be generalized to other genetic screening programs. PMID:7336765

  1. [Sandhoff's and Tay-Sachs disease--based on our own cases].

    PubMed

    Kokot, Witold; Raczyńska, Krystyna; Krajka-Lauer, Jarosława; Iwaszkiewicz-Bilikiewicz, Barbara; Wierzba, Jolanta

    2004-01-01

    The authors described two infant with Sandhoff's and Tay-Sachs disease. Tay-Sachs disease is well-known inherited disease leading to an accumulation of gangliosides in the brain and retina. Sandhoffs disease (GM2 gangliosidosis type 0) was diagnosed in an infant, in whom a progressive neurological disorder and cherry-red foveal spots were developed. In addition, to the general clinical examination, indirect ophthalnoscopy, blood white cells enzymatic examination are used to make definitive diagnosis. In this cases, the early eye fundus examination allowed us to make the proper diagnosis. The fundus change is characterized by the "cherry-red spot" in the central area.

  2. Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.

    PubMed

    Seyrantepe, Volkan; Demir, Secil Akyildiz; Timur, Zehra Kevser; Von Gerichten, Johanna; Marsching, Christian; Erdemli, Esra; Oztas, Emin; Takahashi, Kohta; Yamaguchi, Kazunori; Ates, Nurselin; Demir, Buket Dönmez; Dalkara, Turgay; Erich, Katrin; Hopf, Carsten; Sandhoff, Roger; Miyagi, Taeko

    2017-09-30

    Tay-Sachs disease is a severe lysosomal storage disorder caused by mutations in Hexa, the gene that encodes for the α subunit of lysosomal β-hexosaminidase A (HEXA), which converts GM2 to GM3 ganglioside. Unexpectedly, Hexa(-/-) mice have a normal lifespan and show no obvious neurological impairment until at least one year of age. These mice catabolize stored GM2 ganglioside using sialidase(s) to remove sialic acid and form the glycolipid GA2, which is further processed by β-hexosaminidase B. Therefore, the presence of the sialidase (s) allows the consequences of the Hexa defect to be bypassed. To determine if the sialidase NEU3 contributes to GM2 ganglioside degradation, we generated a mouse model with combined deficiencies of HEXA and NEU3. The Hexa(-/-)Neu3(-/-) mice were healthy at birth, but died at 1.5 to 4.5months of age. Thin-layer chromatography and mass spectrometric analysis of the brains of Hexa(-/-)Neu3(-/-) mice revealed the abnormal accumulation of GM2 ganglioside. Histological and immunohistochemical analysis demonstrated cytoplasmic vacuolation in the neurons. Electron microscopic examination of the brain, kidneys and testes revealed pleomorphic inclusions of many small vesicles and complex lamellar structures. The Hexa(-/-)Neu3(-/-) mice exhibited progressive neurodegeneration with neuronal loss, Purkinje cell depletion, and astrogliosis. Slow movement, ataxia, and tremors were the prominent neurological abnormalities observed in these mice. Furthermore, radiographs revealed abnormalities in the skeletal bones of the Hexa(-/-)Neu3(-/-) mice. Thus, the Hexa(-/-)Neu3(-/-) mice mimic the neuropathological and clinical abnormalities of the classical early-onset Tay-Sachs patients, and provide a suitable model for the future pre-clinical testing of potential treatments for this condition. Copyright © 2017. Published by Elsevier Inc.

  3. [Forms and factors of the variability of paranasal sinuses].

    PubMed

    Nikitiuk, D B

    1983-09-01

    The form, structural variations, sex variations (connected with zygosityz), right and left positions of the sinuses were studied according to the data obtained while measuring the contours of the frontal, sphenoid and maxillary sinuses in the cranial roentgenograms made in the frontal and sagittal projections. By means of the twin method, relationship of the hereditary and environmental influences on the sinus formation was estimated. The data obtained in 111 Ukrainians (30--60 years of age), inhabitants of Vinnitsa region, mono- and dizygote twins of both sex were used. Greater dimensions in the male sinuses and a high variability of their size not connected with sex were stated. Among women the dizygote twin had larger dimensions than the monozygote ones. The sinus size is characterized by a predominant right-sided asymmetry. The hereditary effect is clearly seen in the sinus paranasales formation. A decreasing hereditary influence noted in the maxillary sinus is considered as a dependence of its dimensions on the state of the masticatory apparatus.

  4. Resource Form Factor and Installation of GFA Controllers

    SciTech Connect

    DeSteese, John G.; Hammerstrom, Donald J.

    2009-11-15

    The focus of this task is to optimize the form and placement of a controller comprising the Grid Friendly™ appliance (GFA) controller, power supply and power relay (and/or a solid-state power electronic switch) that would command a domestic water heater to shed its load in response to stress on the electric power grid. The GFA controller would disconnect the water heater from its supply circuit whenever it senses a low voltage signal or other indicators of system stress communicated via the electric power distribution system. Power would be reconnected to the appliance when the GFA controller senses the absence of these signals. This project has also considered more frequent cycling of this controller’s relay switch to perform demand-side frequency regulation. The principal criteria considered in this optimization are reliability, cost and life expectancy of the GFA components. The alternative embodiments of the GFA equipment under consideration are: Option 1- installation inside the insulation space of the water heater between the tank and jacket Option 2 containment in a separate nearby electrical enclosure Option 3 - as a modification or adjunct to the distribution panel housing and/or the breaker that protects the water heater supply circuit.

  5. Highly Efficient Small Form Factor LED Retrofit Lamp

    SciTech Connect

    Steven Allen; Fred Palmer; Ming Li

    2011-09-11

    This report summarizes work to develop a high efficiency LED-based MR16 lamp downlight at OSRAM SYLVANIA under US Department of Energy contract DE-EE0000611. A new multichip LED package, electronic driver, and reflector optic were developed for these lamps. At steady-state, the lamp luminous flux was 409 lumens (lm), luminous efficacy of 87 lumens per watt (LPW), CRI (Ra) of 87, and R9 of 85 at a correlated color temperature (CCT) of 3285K. The LED alone achieved 120 lumens per watt efficacy and 600 lumen flux output at 25 C. The driver had 90% electrical conversion efficiency while maintaining excellent power quality with power factor >0.90 at a power of only 5 watts. Compared to similar existing MR16 lamps using LED sources, these lamps had much higher efficacy and color quality. The objective of this work was to demonstrate a LED-based MR16 retrofit lamp for replacement of 35W halogen MR16 lamps having (1) luminous flux of 500 lumens, (2) luminous efficacy of 100 lumens per watt, (3) beam angle less than 40{sup o} and center beam candlepower of at least 1000 candelas, and (4) excellent color quality.

  6. Bethe ansatz and exact form factors of the O(6) Gross Neveu-model

    NASA Astrophysics Data System (ADS)

    Babujian, Hrachya M.; Foerster, Angela; Karowski, Michael

    2017-08-01

    The isomorphism SU(4)≃ O(6) is used to construct the form factors of the O(6) Gross-Neveu model as bound state form factors of the SU(4) chiral Gross-Neveu model. This technique is generalized and is then applied to use the O(6) as the starting point of the nesting procedure to obtain the O(N) form factors for general even N. Dedicated to the memory of Petr Petrovich Kulish.

  7. Planck 2015 results. XXI. The integrated Sachs-Wolfe effect

    NASA Astrophysics Data System (ADS)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Casaponsa, B.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Fernandez-Cobos, R.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and the NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that ΩΛ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the

  8. Planck 2015 results: XXI. The integrated Sachs-Wolfe effect

    DOE PAGES

    Ade, P. A. R.; Aghanim, N.; Arnaud, M.; ...

    2016-09-20

    Here, this paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and themore » NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that ΩΛ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by

  9. Calculation of the Nucleon Axial Form Factor Using Staggered Lattice QCD

    SciTech Connect

    Meyer, Aaron S.; Hill, Richard J.; Kronfeld, Andreas S.; Li, Ruizi; Simone, James N.

    2016-10-14

    The nucleon axial form factor is a dominant contribution to errors in neutrino oscillation studies. Lattice QCD calculations can help control theory errors by providing first-principles information on nucleon form factors. In these proceedings, we present preliminary results on a blinded calculation of $g_A$ and the axial form factor using HISQ staggered baryons with 2+1+1 flavors of sea quarks. Calculations are done using physical light quark masses and are absolutely normalized. We discuss fitting form factor data with the model-independent $z$ expansion parametrization.

  10. Difficulty in determining the pion form factor at high Q2

    NASA Astrophysics Data System (ADS)

    Carlson, C. E.; Milana, Joseph

    1990-10-01

    We reexamine the determination of the pion form factor at large spacelike Q2 via the reaction ep-->enπ+ and find that, because of the magnitude of the pion-nucleon form factor and the existence of competing hitherto uncalculated processes in QCD, the pion electromagnetic form factor is not sufficiently well determined at higher Q2 to compare with the expected scaling prediction of QCD. Instead, we conclude that the best way to get information about the pion electromagnetic form factor is to study π0 production.

  11. Up- and Down-Quark Contributions to the Nucleon Form Factors

    NASA Astrophysics Data System (ADS)

    Qattan, I. A.; Arrington, J.

    2014-03-01

    Recent measurements of the neutron s electric to magnetic form factors ratio, Rn = µnGnE/GnM, up to 3.4 (GeV/c)2 combined with existing Rp = µpGpE/GpM measurements in the same Q2 range allowed, for the first time, a separation of the up- and downquark contributions to the form factors at high Q2, as presented by Cates, et al.. Our analysis expands on the original work by including additional form factor data, applying two-photon exchange (TPE) corrections, and accounting for the uncertainties associated with all of the form factor measurements.

  12. A pseudodeficiency allele common in non-Jewish Tay-Sachs carriers: Implications for carrier screening

    SciTech Connect

    Triggs-Raine, B.L.; Akerman, B.R.; Gravel, R.A. ); Mules, E.H.; Thomas, G.H.; Dowling, C.E. ); Kaback, M.M.; Lim-Steele, J.S.T. ); Natowicz, M.R. ); Grebner, E.E. ); Navon, R.R. ); Welch, J.P. ); Greenberg, C.R. )

    1992-10-01

    Deficiency of [beta]-hexosaminidase A (Hex A) activity typically results in Tay-Sachs disease. However, healthy subjects found to be deficient in Hex A activity (i.e., pseudodeficient) by means of in vitro biochemical tests have been described. The authors analyzed the HEXA gene of one pseudodeficient subject and identified both a C[sub 739]-to-T substitution that changes Arg[sub 247][yields]Trp on one allele and a previously identified Tay-Sachs disease mutation of the second allele. Six additional pseudodeficient subjects were found to have the C[sub 739]-to-T but for none of 36 Jewish enzyme-defined carries who did not have one of three known mutations common to this group. The C[sub 739]-to-T allele, together with a [open quotes]true[close quotes] Tay-Sachs disease allele, causes Hex A pseudodeficiency. Given both the large proportion of non-Jewish carriers with this allele and that standard biochemical screening cannot differentiate between heterozygotes for the C[sub 739]-to-T mutations and Tay-Sachs disease carriers, DNA testing for this mutation in at-risk couples is essential. This could prevent unnecessary or incorrect prenatal diagnoses. 40 refs., 3 figs., 4 tabs.

  13. Late-onset Tay-Sachs disease: adverse effects of medications and implications for treatment.

    PubMed

    Shapiro, B E; Hatters-Friedman, S; Fernandes-Filho, J A; Anthony, K; Natowicz, M R

    2006-09-12

    The authors conducted a retrospective and brief prospective study of adverse effects of approximately 350 medications in 44 adults with late-onset Tay-Sachs disease (LOTS). Some medications were relatively safe, whereas others, particularly haloperidol, risperidone, and chlorpromazine, were associated with neurologic worsening.

  14. Tay-Sachs disease: high gene frequency in a non-Jewish population.

    PubMed Central

    Kelly, T E; Chase, G A; Kaback, M M; Kumor, K; McKusick, V A

    1975-01-01

    A non-Amish "Pennsylvania Dutch" semi-isolate was found to have a high frequency of Tay-Sachs gene. This high frequency could be ascribed to founder effect and may represent, in microcosm, how this mechanism could have produced the high gene frequency among Ashkenazi Jews. PMID:803011

  15. 78 FR 24447 - Goldman Sachs Trust, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... companies, Government securities, and short-term paper; (iii) the aggregate sales loads and distribution... investment company in the same group of investment companies, Government securities, and short-term paper: (i... Variable Insurance Trust (each a ``Trust,'' together, the ``Trusts''), Goldman Sachs Asset Management,...

  16. Transient HEXA expression in a transformed human fetal Tay-Sachs disease neuroglial cell line

    SciTech Connect

    Fernandes, M.J.; Hechtman, P.; Kaplan, F.

    1994-09-01

    Tay-Sachs disease (TSD) is a severe neurodegenerative disorder characterized by the accumulation of GM{sub 2} ganglioside in the neurons of the central cortex. The recessively inherited disorder results from deficiency of hexosaminidase A (Hex A), a heterodimer of an {alpha} and {beta} subunit encoded by the HEXA and HEXB genes. Expression of HEXA mutations in COS cells has several disadvantages including high endogenous hexosaminidase activity. We report a new transient expression system with very low endogenous Hex A activity. An SV40-transformed fetal TSD neuroglial cell line was assessed for transient expression of the HEXA gene. pCMV{alpha}, a vector incorporating the cytomegalovirus promoter with the human {alpha}-subunit cDNA insert, proved to be the most efficient expression vector. Transfection of 4x10{sup 6} cells with 5-20 {mu}g of plasmid resulted in 100 to 500-fold Hex A activity (4MUGS hydrolysis) relative to mock-transfected cells. Use of pCMV{beta}-Gal as a control for transfection efficiency indicated that 10-20% of cells were transfected. Hex A specific activity increased for at least 72 h post-transfection. This new transient expression system should greatly improve the characterization of mutations in which low levels of HEXA expression result in milder clinical phenotypes and permit studies on enzymatic properties of mutant forms of Hex A. Since the cells used are of CNS origin and synthesize gangliosides, it should also be possible to study, in culture, the metabolic phenotype associated with TSD.

  17. Model Independent Constraints on Hadron Form Factors at Large Q2 in Light-Front QCD

    NASA Astrophysics Data System (ADS)

    Ji, Chueng-Ryong

    2014-01-01

    Among the three forms of relativistic Hamiltonian dynamics proposed by Dirac in 1949, the front form has the largest number of kinematic generators. This distinction provides useful consequences in the analysis of physical observables in hadron physics. We discuss a rationale for using the front form dynamics, known nowadays as the light-front dynamics (LFD), and present a few explicit examples of hadron phenomenology that the front form uniquely can offer from the first principle QCD. In particular, model independent constraints are provided for the analyses of deuteron form factors and the NΔ transition form factors at large momentum transfer square Q2.

  18. Factor Structure and Construct Validity of the Counselor Skills Personal Development Rating Form.

    ERIC Educational Resources Information Center

    Torres-Rivera, Edil; Wilbur, Michael P.; Maddux, Cleborne D.; Smaby, Marlowe H.; Phan, Loan T.; Roberts-Wilbur, Janice

    2002-01-01

    Presents an exploratory factor analysis of the scores of 248 counselors-in-training on the Counselor Skills Personal Development Rating Form (CSPD-RF). Authors of the test hypothesized that the CPSD-RF measured 2 factors, personal development and skills development. Factor analysis revealed 4 factors accounting for 58.4% of the total variance,…

  19. Calculating the Sachs-Wolfe Effect from Solutions of Null Geodesics in Perturbed FRW Spacetime

    NASA Astrophysics Data System (ADS)

    Arroyo-Cárdenas, C. A.; Muñoz-Cuartas, J. C.

    2017-07-01

    In the upcoming precision era in cosmology, fine grained effects will be measured accurately. In particular, the late integrated Sachs-Wolfe (ISW) effect measurements will be improved to levels of unprecedented precision. The ISW consists on temperature fluctuations in the CMB due to gravitational redshift induced by the evolving potential well of large scale structure in the Universe. Currently there is large controversy related to the actual observability of the ISW effect. In principle, it is expected that, as an effect of the late accelerated expansion of the universe motivated by the current amount of dark energy, large scale structures may evolve rapidly, inducing an observable signature in the CMB photons in the way of a ISW anisotropy in the CMB. Tension arises since using galaxy redshift surveys some works report a temperature fluctuations with amplitude smaller than predicted by the Lambda-CDM. We argue that these discrepancies may be originated in the approximation that one has to make to get the classic Sachs-Wolfe effect. In this work, we compare the classic Sachs-Wolfe approximation with an exact solution to the propagation of photons in a dynamical background. We solve numerically the null geodesics on a perturbed FRW spacetime in the Newtonian gauge. From null geodesics, temperature fluctuations in the CMB due to the evolving potential has been calculated. Since solving geodesics accounts for more terms than solving the Sachs-Wolfe (approximated) integral, our results are more accurate. We have been able to substract the background cosmological redshift with the information provided by null geodesics, which allows to get an estimate of the integrated Sachs-Wolfe effect contribution to the temperature of the CMB.

  20. Flavor decomposition of the nucleon electromagnetic form factors at low Q2

    NASA Astrophysics Data System (ADS)

    Qattan, I. A.; Arrington, J.; Alsaad, A.

    2015-06-01

    Background: The spatial distribution of charge and magnetization within the proton is encoded in the elastic form factors. These have been precisely measured in elastic electron scattering, and the combination of proton and neutron form factors allows for the separation of the up- and down-quark contributions. Purpose: In this work, we extract the proton and neutron form factors from worldwide data with an emphasis on precise new data covering the low-momentum region, which is sensitive to the large-scale structure of the nucleon. From these, we separate the up- and down-quark contributions to the proton form factors. Method: We combine cross section and polarization measurements of elastic electron-proton scattering to separate the proton form factors and two-photon exchange (TPE) contributions. We combine the proton form factors with parametrization of the neutron form factor data and uncertainties to separate the up- and down-quark contributions to the proton's charge and magnetic form factors. Results: The extracted TPE corrections are compared to previous phenomenological extractions, TPE calculations, and direct measurements from the comparison of electron and positron scattering. The flavor-separated form factors are extracted and compared to models of the nucleon structure. Conclusions: With the inclusion of the precise new data, the extracted TPE contributions show a clear change of sign at low Q2, which is necessary to explain the high-Q2 form factor discrepancy while being consistent with the known Q2→0 limit. We find that the new Mainz data yield a significantly different result for the proton magnetic form factor and its flavor-separated contributions. We also observe that the rms radius of both the up- and down-quark distributions are smaller than the rms charge radius of the proton.

  1. Tay Sachs disease in Australia: reduced disease incidence despite stable carrier frequency in Australian Jews.

    PubMed

    Lew, Raelia M; Proos, Anne L; Burnett, Leslie; Delatycki, Martin; Bankier, Agnes; Fietz, Michael J

    2012-12-10

    To evaluate the outcomes of preconception screening of Jewish Australians for Tay Sachs disease (TSD) carrier status on Jewish TSD-affected births. Epidemiological observational study involving a complete retrospective audit of infantile and intermediate TSD cases diagnosed in Sydney and Melbourne between 1 January 1995 and 31 December 2011 (Royal Children's Hospital Melbourne; Pacific Laboratory Medicine Services, Pathology North, NSW Health Pathology, Sydney; Victorian Clinical Genetics Services, Melbourne; and SA Pathology, Adelaide), and carrier frequency among Jewish high school students attending schools participating in TSD screening programs over the same period. Jewish TSD carrier frequency; and expected versus observed Jewish TSD-affected births. The 2006 Census indicated that most of the total 88,826 Jewish Australians live in Melbourne (46%) and Sydney (40%). The 7,756 Jewish high school students screened for TSD in Sydney and Melbourne during the study period had a carrier frequency of one in 31 (3.26%; 95% CI, 2.89%-3.68%).The estimated expected number of TSD-affected births in Melbourne and Sydney in 1995-2011 was 4.1 for Jewish births and 7.4 for other births (a ratio of Jewish to non-Jewish births of 1:2). The actual number was 12 (four in Sydney and eight in Melbourne), of which two were Jewish (a ratio of Jewish to non-Jewish births of 1:5). This finding of fewer than expected Jewish TSD cases coincided with a period during which screening programs were operating. There have been no Jewish TSD-affected children born to parents who were screened previously. Community education, appreciation of autosomal recessive inheritance and genetic carrier screening before pregnancy are the likely factors in our finding of fewer than expected Jewish babies with TSD. Ongoing outcome monitoring must continue.

  2. Quark and gluon form factors to four-loop order in QCD: The Nf3 contributions

    NASA Astrophysics Data System (ADS)

    von Manteuffel, Andreas; Schabinger, Robert M.

    2017-02-01

    We calculate the four-loop massless QCD corrections with three closed quark lines to quark and gluon form factors. We apply a novel integration by parts algorithm based on modular arithmetic and compute all relevant master integrals for arbitrary values of the space-time dimension. This is the first calculation of a gluon form factor at this perturbative order in QCD.

  3. Nucleon form factors from high statistics mixed-action calculations with 2+1 flavors

    SciTech Connect

    Schroers, Wolfram; Edwards, Robert G; Engelhardt, Michael; Fleming, George Taminga; Hagler, Philipp; Lin, Huey-Wen; Lin, Mei-Feng; Meyer, Harvey B; Musch, Bernhard; Negele, John W; Orginos, Kostas; Pochinsky, Andrew V; Procura, Massimiliano; Renner, Dru B; Richards, David G; Syritsyn, Sergey N; Walker-Loud, Andre P

    2009-12-01

    We present new high-statistics results for nucleon form factors at pion masses of approximately 290, 350, 500, and 600 MeV using a mixed action of domain wall valence quarks on an improved staggered sea. We perform chiral fits to both vector and axial form factors and compare our results to experiment.

  4. Form factors in quantum integrable models with GL(3)-invariant R-matrix

    NASA Astrophysics Data System (ADS)

    Pakuliak, S.; Ragoucy, E.; Slavnov, N. A.

    2014-04-01

    We study integrable models solvable by the nested algebraic Bethe ansatz and possessing GL(3)-invariant R-matrix. We obtain determinant representations for form factors of off-diagonal entries of the monodromy matrix. These representations can be used for the calculation of form factors and correlation functions of the XXX SU(3)-invariant Heisenberg chain.

  5. 48 CFR 247.372 - DD Form 1654, Evaluation of Transportation Cost Factors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1654, Evaluation... Transportation in Supply Contracts 247.372 DD Form 1654, Evaluation of Transportation Cost Factors. Contracting personnel may use the DD Form 1654 to furnish information to the transportation office for development...

  6. 48 CFR 247.372 - DD Form 1654, Evaluation of Transportation Cost Factors.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false DD Form 1654, Evaluation... Transportation in Supply Contracts 247.372 DD Form 1654, Evaluation of Transportation Cost Factors. Contracting personnel may use the DD Form 1654 to furnish information to the transportation office for development...

  7. Analysis of nucleon electromagnetic form factors from light-front holographic QCD: The spacelike region

    NASA Astrophysics Data System (ADS)

    Sufian, Raza Sabbir; de Téramond, Guy F.; Brodsky, Stanley J.; Deur, Alexandre; Dosch, Hans Günter

    2017-01-01

    We present a comprehensive analysis of the spacelike nucleon electromagnetic form factors and their flavor decomposition within the framework of light-front (LF) holographic QCD (LFHQCD) We show that the inclusion of the higher Fock components |q q q q q ¯ ⟩ has a significant effect on the spin-flip elastic Pauli form factor and almost zero effect on the spin-conserving Dirac form factor. We present light-front holographic QCD results for the proton and neutron form factors at any momentum transfer range, including asymptotic predictions, and show that our results agree with the available experimental data with high accuracy. In order to correctly describe the Pauli form factor we need an admixture of a five quark state of about 30% in the proton and about 40% in the neutron. We also extract the nucleon charge and magnetic radii and perform a flavor decomposition of the nucleon electromagnetic form factors. The free parameters needed to describe the experimental nucleon form factors are very few: two parameters for the probabilities of higher Fock states for the spin-flip form factor and a phenomenological parameter r , required to account for possible SU(6) spin-flavor symmetry breaking effects in the neutron, whereas the Pauli form factors are normalized to the experimental values of the anomalous magnetic moments. The covariant spin structure for the Dirac and Pauli nucleon form factors prescribed by AdS5 semiclassical gravity incorporates the correct twist scaling behavior from hard scattering and also leads to vector dominance at low energy.

  8. Analysis of nucleon electromagnetic form factors from light-front holographic QCD: The spacelike region

    DOE PAGES

    Sufian, Raza Sabbir; de Teramond, Guy F.; Brodsky, Stanley J.; ...

    2017-01-10

    We present a comprehensive analysis of the space-like nucleon electromagnetic form factors and their flavor decomposition within the framework of light-front holographic QCD. We show that the inclusion of the higher Fock componentsmore » $$|{qqqq\\bar{q}}$$ has a significant effect on the spin-flip elastic Pauli form factor and almost zero effect on the spin-conserving Dirac form factor. We present light-front holographic QCD results for the proton and neutron form factors at any momentum transfer range, including asymptotic predictions, and show that our results agree with the available experimental data with high accuracy. In order to correctly describe the Pauli form factor we need an admixture of a five quark state of about 30$$\\%$$ in the proton and about 40$$\\%$$ in the neutron. We also extract the nucleon charge and magnetic radii and perform a flavor decomposition of the nucleon electromagnetic form factors. The free parameters needed to describe the experimental nucleon form factors are very few: two parameters for the probabilities of higher Fock states for the spin-flip form factor and a phenomenological parameter $r$, required to account for possible SU(6) spin-flavor symmetry breaking effects in the neutron, whereas the Pauli form factors are normalized to the experimental values of the anomalous magnetic moments. As a result, the covariant spin structure for the Dirac and Pauli nucleon form factors prescribed by AdS$$_5$$ semiclassical gravity incorporates the correct twist scaling behavior from hard scattering and also leads to vector dominance at low energy.« less

  9. A Factor Analytic Study of the Coopersmith Self-Esteem Inventory Adult Short Form.

    ERIC Educational Resources Information Center

    Haines, Janet; Wilson, George V.

    1988-01-01

    A factor analysis was conducted on the Coopersmith Self-Esteem Inventory-Adult Short Form using 237 college students and 43 female office workers in Australia. Factors were found corresponding with three of the four subscales: general self, social self-peers, and home-parents (family). No factor related to the school-academic (work) subscale. (SLD)

  10. The frequency of Tay-Sachs disease causing mutations in the Brazilian Jewish population justifies a carrier screening program.

    PubMed

    Rozenberg, R; Pereira, L da V

    2001-07-05

    Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populations in several countries. The Brazilian Jewish population is estimated at 90,000 individuals. Currently, there is no screening program for Tay-Sachs disease in this population. To evaluate the importance of a Tay-Sachs disease carrier screening program in the Brazilian Jewish population by determining the frequency of heterozygotes and the acceptance of the program by the community. Laboratory of Molecular Genetics--Institute of Biosciences--Universidade de São Paulo. 581 senior students from selected Jewish high schools. Molecular analysis of Tay-Sachs disease causing mutations by PCR amplification of genomic DNA, followed by restriction enzyme digestion. Among 581 students that attended educational classes, 404 (70%) elected to be tested for Tay-Sachs disease mutations. Of these, approximately 65% were of Ashkenazi Jewish origin. Eight carriers were detected corresponding to a carrier frequency of 1 in every 33 individuals in the Ashkenazi Jewish fraction of the sample. The frequency of Tay-Sachs disease carriers among the Ashkenazi Jewish population of Brazil is similar to that of other countries where carrier screening programs have led to a significant decrease in disease incidence. Therefore, it is justifiable to implement a Tay-Sachs disease carrier screening program for the Brazilian Jewish population.

  11. Assessment of coincidence and defect sizes in Bankart and Hill-Sachs lesions after anterior shoulder dislocation: a radiological study.

    PubMed

    Horst, K; Von Harten, R; Weber, C; Andruszkow, H; Pfeifer, R; Dienstknecht, T; Pape, H C

    2014-02-01

    Bankart and Hill-Sachs lesions are often associated with anterior shoulder dislocation. The MRI technique is sensitive in diagnosing both injuries. The aim of this study was to investigate Bankart and Hill-Sachs lesions with MRI to determine the correlation in occurrence and defect sizes of these lesions. Between 2006 and 2013, 446 patients were diagnosed with an anterior shoulder dislocation and 105 of these patients were eligible for inclusion in the study. All patients were examined using MRI. Bankart lesions were classified as cartilaginous or bony lesions. Hill-Sachs lesions were graded I-III using a modified Calandra classification. The co-occurrence of injuries was high [odds ratio (OR) = 11.47; 95% confidence interval (CI) = 3.60-36.52; p < 0.001]. Patients older than 29 years more often presented with a bilateral injury (OR = 16.29; 95% CI = 2.71-97.73; p = 0.002). A correlation between a Bankart lesion and the grade of a Hill-Sachs lesion was found (ρ = 0.34; 95% CI = 0.16-0.49; p < 0.001). Bankart lesions co-occurred more often with large Hill-Sachs lesions (O  = 1.24; 95% CI = 1.02-1.52; p = 0.033). If either lesion is diagnosed, the patient is 11 times more likely to have suffered the associated injury. The size of a Hill-Sachs lesion determines the co-occurrence of cartilaginous or bony Bankart lesions. Age plays a role in determining the type of Bankart lesion as well as the co-occurrence of Bankart and Hill-Sachs lesions. This study is the first to demonstrate the use of high-quality MRI in a reasonably large sample of patients, a positive correlation of Bankart and Hill-Sachs lesions in anterior shoulder dislocations and an association between the defect sizes.

  12. Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

    PubMed

    Hussein, Norita; Weng, Stephen F; Kai, Joe; Kleijnen, Jos; Qureshi, Nadeem

    2015-08-12

    Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rates in specific patient populations. Identifying and counselling couples at genetic risk of the conditions before pregnancy enables them to make fully informed reproductive decisions, with some of these choices not being available if genetic counselling is only offered in an antenatal setting. To assess the effectiveness of systematic preconception genetic risk assessment to improve reproductive outcomes in women and their partners who are identified as carriers of thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease in healthcare settings when compared to usual care. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Registers. In addition, we searched for all relevant trials from 1970 (or the date at which the database was first available if after 1970) to date using electronic databases (MEDLINE, Embase, CINAHL, PsycINFO), clinical trial databases (National Institutes of Health, Clinical Trials Search portal of the World Health Organization, metaRegister of controlled clinical trials), and hand searching of key journals and conference abstract books from 1998 to date (European Journal of Human Genetics, Genetics in Medicine, Journal of Community Genetics). We also searched the reference lists of relevant articles, reviews and guidelines and also contacted subject experts in the field to request any unpublished or other published trials.Date of latest search of the registers: 25 June 2015.Date of latest search of all other sources: 10 December 2014. Any randomised or quasi-randomised control trials (published or unpublished) comparing reproductive outcomes of systematic preconception genetic risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease

  13. Does the Arthroscopic Latarjet Procedure Effectively Correct "Off-Track" Hill-Sachs Lesions?

    PubMed

    Plath, Johannes E; Henderson, Daniel J H; Coquay, Julien; Dück, Klaus; Haeni, David; Lafosse, Laurent

    2017-09-01

    The glenoid track concept describes the dynamic interaction of bipolar bone loss in anterior glenohumeral instability. Initial studies have successfully demonstrated this concept's application in clinical populations. In clinical practice, the Latarjet procedure is commonly the preferred treatment in addressing "off-track" Hill-Sachs lesions. The effectiveness of this procedure in restoring such lesions to an "on-track" state, however, has not yet been evaluated or described in the literature. The Latarjet procedure would transform "off-track" Hill-Sachs lesions to "on-track" lesions. Lesions would remain "on-track" during follow-up, despite glenoid remodeling. Case series; Level of evidence, 4. Patients with "off-track" Hill-Sachs lesions treated with the arthroscopic Latarjet procedure between March 2013 and May 2014 were included. Glenoid track and coracoid graft contact surface area measurements using 3-dimensional computed tomography (3D-CT) were performed preoperatively and at 6-week, 6-month, and at least 12-month (final) follow-up. The mean final follow-up was 23 months. The glenoid diameter, as a percentage of the native glenoid, was also calculated from this imaging. Twenty-six patients met the inclusion criteria. 3D-CT scans were available for all patients preoperatively and postoperatively, with 21 patients (81%) undergoing 6-month follow-up CT and 19 patients (73%) undergoing final follow-up CT. Hill-Sachs lesions remained "on-track" at all follow-up time points. The mean glenoid diameter changed significantly from 84.6% preoperatively to 122.8% at 6 weeks ( P < .001) and from 120.5% at 6 months to 113.9% at final follow-up ( P = .005). This was also reflected in significant remodeling seen in the coracoid graft articular contact area (6 weeks to 6 months, P = .024; 6 months to final follow-up, P = .002). This persisting glenoid arc enlargement at final follow-up avoided "off-track" Hill-Sachs lesions in 6 of 19 patients (32%), which would otherwise

  14. Assessing the potential success of cystic fibrosis carrier screening: lessons learned from Tay-Sachs disease and beta-thalassemia.

    PubMed

    Laberge, A-M; Watts, C; Porter, K; Burke, W

    2010-01-01

    The objective of this study was to identify factors involved in the success of 2 well-established population-based carrier screening programs - Tay-Sachs disease (TSD) in Ashkenazi Jews and beta-thalassemia in Sardinia and Cyprus - and to assess the potential for success of a population-based cystic fibrosis (CF) carrier screening strategy using these factors. We performed a literature review and key informant interviews. Factors involved in the success of TSD and beta-thalassemia carrier screening programs include disease characteristics (well-defined population at risk, severe disease with predictable course, availability of effective treatment), test characteristics (high sensitivity, straightforward interpretation of results), and community characteristics (involvement of community, support of families and advocacy groups, consensus in favor of avoiding affected births). Current CF screening strategies include few of the factors listed above. Unlike TSD and beta-thalassemia, the purpose of current CF carrier screening strategies is informed reproductive decision-making, without an explicit goal of reducing disease incidence. When compared to TSD and beta-thalassemia, CF is a less favorable candidate for population-based carrier screening. Because of its different purpose, CF carrier screening will require different measures of success than those used for TSD and beta-thalassemia carrier screening, and a consensus on the value or success of CF carrier screening may be difficult to achieve.

  15. In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease.

    PubMed

    Kato, Atsushi; Nakagome, Izumi; Nakagawa, Shinpei; Kinami, Kyoko; Adachi, Isao; Jenkinson, Sarah F; Désiré, Jérôme; Blériot, Yves; Nash, Robert J; Fleet, George W J; Hirono, Shuichi

    2017-09-29

    The affinity of a series of iminosugar-based inhibitors exhibiting various ring sizes toward Hex A and their essential interactions with the enzyme active site were investigated. All the Hex A-inhibiting iminosugars tested formed hydrogen bonds with Arg178, Asp322, Tyr421 and Glu462 and had the favorable cation-π interaction with Trp460. Among them, DMDP amide (6) proved to be the most potent competitive inhibitor with a Ki value of 0.041 μM. We analyzed the dynamic properties of both DMDP amide (6) and DNJNAc (1) in aqueous solution using molecular dynamics (MD) calculations; the distance of the interaction between Asp322 and 3-OH and Glu323 and 6-OH was important for stable interactions with Hex A, reducing fluctuations in the plasticity of the active site. DMDP amide (6) dose-dependently increased intracellular Hex A activity in the G269S mutant cells and restored Hex A activity up to approximately 43% of the wild type level; this effect clearly exceeded the border line treatment for Tay-Sachs disease, which is regarded as 10-15% of the wild type level. This is a significantly greater effect than that of pyrimethamine, which is currently in Phase 2 clinical trials. DMDP amide (6), therefore, represents a new promising pharmacological chaperone candidate for the treatment of Tay-Sachs disease.

  16. Can Nonrelativistic QCD Explain the γγ^{*}→η_{c} Transition Form Factor Data?

    PubMed

    Feng, Feng; Jia, Yu; Sang, Wen-Long

    2015-11-27

    Unlike the bewildering situation in the γγ^{*}→π form factor, a widespread view is that perturbative QCD can decently account for the recent BABAR measurement of the γγ^{*}→η_{c} transition form factor. The next-to-next-to-leading-order perturbative correction to the γγ^{*}→η_{c,b} form factor, is investigated in the nonrelativistic QCD (NRQCD) factorization framework for the first time. As a byproduct, we obtain, by far, the most precise order-α_{s}^{2} NRQCD matching coefficient for the η_{c,b}→γγ process. After including the substantial negative order-α_{s}^{2} correction, the good agreement between NRQCD prediction and the measured γγ^{*}→η_{c} form factor is completely ruined over a wide range of momentum transfer squared. This eminent discrepancy casts some doubts on the applicability of the NRQCD approach to hard exclusive reactions involving charmonium.

  17. An experimental survey of the factors that affect leaching from low-level radioactive waste forms

    SciTech Connect

    Dougherty, D.R.; Pietrzak, R.F.; Fuhrmann, M.; Colombo, P.

    1988-09-01

    This report represents the results of an experimental survey of the factors that affect leaching from several types of solidified low-level radioactive waste forms. The goal of these investigations was to determine those factors that accelerate leaching without changing its mechanism(s). Typically, although not in every case,the accelerating factors include: increased temperature, increased waste loading (i.e., increased waste to binder ratio), and decreased size (i.e., decreased waste form volume to surface area ratio). Additional factors that were studied were: increased leachant volume to waste form surface area ratio, pH, leachant composition (groundwaters, natural and synthetic chelating agents), leachant flow rate or replacement frequency and waste form porosity and surface condition. Other potential factors, including the radiation environment and pressure, were omitted based on a survey of the literature. 82 refs., 236 figs., 13 tabs.

  18. Recoil polarization measurements of the proton electromagnetic form factor ratio at high momentum transfer

    SciTech Connect

    Andrew Puckett

    2009-12-01

    Electromagnetic form factors are fundamental properties of the nucleon that describe the effect of its internal quark structure on the cross section and spin observables in elastic lepton-nucleon scattering. Double-polarization experiments have become the preferred technique to measure the proton and neutron electric form factors at high momentum transfers. The recently completed GEp-III experiment at the Thomas Jefferson National Accelerator Facility used the recoil polarization method to extend the knowledge of the proton electromagnetic form factor ratio GpE/GpM to Q2 = 8.5 GeV2. In this paper we present the preliminary results of the experiment.

  19. Parity-Violating Electron Scattering and the Electric and Magnetic Strange Form Factors of the Nucleon

    SciTech Connect

    Armstrong, David S.; McKeown, Robert

    2012-11-01

    Measurement of the neutral weak vector form factors of the nucleon provides unique access to the strange quark content of the nucleon. These form factors can be studied using parity-violating electron scattering. A comprehensive program of experiments has been performed at three accelerator laboratories to determine the role of strange quarks in the electromagnetic form factors of the nucleon. This article reviews the remarkable technical progress associated with this program, describes the various methods used in the different experiments, and summarizes the physics results along with recent theoretical calculations.

  20. Pion Form Factor in Chiral Limit of Hard-Wall AdS/QCD Model

    SciTech Connect

    Anatoly Radyushkin; Hovhannes Grigoryan

    2007-12-01

    We develop a formalism to calculate form factor and charge density distribution of pion in the chiral limit using the holographic dual model of QCD with hard-wall cutoff. We introduce two conjugate pion wave functions and present analytic expressions for these functions and for the pion form factor. They allow to relate such observables as the pion decay constant and the pion charge electric radius to the values of chiral condensate and hard-wall cutoff scale. The evolution of the pion form factor to large values of the momentum transfer is discussed, and results are compared to existing experimental data.

  1. Measurements of the elastic electromagnetic form factor ratio {mu}pGEp/GMp via polarization transfer

    SciTech Connect

    Olivier Gayou; Oleksandr Glamazdin; Andrei Afanasev; Arunava Saha; Brendan Fox; Bogdan Wojtsekhowski; C. Chang; Cathleen Jones; Charles Glashausser; Charles Perdrisat; D. Crovelli; Daniel Simon; David Meekins; Demetrius Margaziotis; Dipangkar Dutta; Edgar Kooijman; Elaine Schulte; Edward Brash; Edward Kinney; Eugene Chudakov; Feng Xiong; Franco Garibaldi; Garth Huber; Gerfried Kumbartzki; Guido Urciuoli; Haiyan Gao; Jordan Hovdebo; James Kelly; Javier Gomez; Jens-Ole Hansen; Jian-Ping Chen; John Calarco; John LeRose; Joseph Mitchell; Juncai Gao; Konrad Aniol; Kamal Benslama; Kathy McCormick; Cornelis De Jager; Cornelis de Jager; Kevin Fissum; Krishni Wijesooriya; Louis Bimbot; Ludyvine Morand; Luminita Todor; Moskov Amarian; Marat Rvachev; Mark Jones; Martin Epstein; Meihua Liang; Michael Kuss; Nilanga Liyanage; Adam Sarty; Paul Ulmer; Pete Markowitz; Peter Bosted; R. Holt; Riad Suleiman; Richard Lindgren; Rikki Roche; Robert Michaels; Roman Pomatsalyuk; Ronald Gilman; Ronald Ransome; Stephen Becher; Scott Dumalski; Salvatore Frullani; Seonho Choi; Sergey Malov; Sonja Dieterich; Steffen Strauch; Steve Churchwell; Ting Chang; Viktor Gorbenko; Vina Punjabi; Wang Xu; Xiangdong Ji; Zein-Eddine Meziani; Zhengwei Chai

    2001-09-01

    We present measurements of the ratio of the proton elastic electromagnetic form factors, {mu}pGEp/GMp. The Jefferson Lab Hall A Focal Plane Polarimeter was used to determine the longitudinal and transverse components of the recoil proton polarization in ep elastic scattering; the ratio of these polarization components is proportional to the ratio of the two form factors. These data reproduce the observation of Jones et al. [Phys. Rev. Lett. 84, 1398 (2000)], that the form factor ratio decreases significantly from unity above Q2 = 1 GeV2.

  2. The Charge Form Factors of the Three- and Four-Body Nuclei

    SciTech Connect

    R. Schiavilla; V.R. Pandharipande; D.O. Riska

    1990-01-01

    The charge form factors of 3H, 3He, and 4He are calculated using the Monte Carlo method and variational ground-state wave functions obtained for the Argonne two-nucleon and Urbana-VII three-nucleon interactions. The model for the charge density operator contains the two-body exchange contributions of longest range. With some spread due to the uncertainty in the electromagnetic form factors of the nucleon the calculated charge form factors are in good agreement with the empirical values over the whole experimentally covered range of momentum transfer.

  3. Delta and Omega electromagnetic form factors in a Dyson-Schwinger/Bethe-Salpeter approach

    SciTech Connect

    Diana Nicmorus, Gernot Eichmann, Reinhard Alkofer

    2010-12-01

    We investigate the electromagnetic form factors of the Delta and the Omega baryons within the Poincare-covariant framework of Dyson-Schwinger and Bethe-Salpeter equations. The three-quark core contributions of the form factors are evaluated by employing a quark-diquark approximation. We use a consistent setup for the quark-gluon dressing, the quark-quark bound-state kernel and the quark-photon interaction. Our predictions for the multipole form factors are compatible with available experimental data and quark-model estimates. The current-quark mass evolution of the static electromagnetic properties agrees with results provided by lattice calculations.

  4. Symmetry Relations for Heavy-to-Light Meson Form Factors at Large Recoil

    SciTech Connect

    Hill, R.

    2004-11-10

    The description of large-recoil heavy-to-light meson form factors is reviewed in the framework of soft-collinear effective theory. At leading power in the heavy-quark expansion, three classes of approximate symmetry relations arise. The relations are compared to experimental data for D {yields} K* and D{sub s} {yields} {phi} form factors, and to light-cone QCD sum rule predictions for B {yields} {pi} and B {yields} {rho} form factors. Implications for the extraction of |V{sub ub}| from semileptonic B {yields} {rho} decays are discussed.

  5. An Investigation of the Factor Structure and Convergent and Discriminant Validity of the Five-Factor Model Rating Form

    ERIC Educational Resources Information Center

    Samuel, Douglas B.; Mullins-Sweatt, Stephanie N.; Widiger, Thomas A.

    2013-01-01

    The Five-Factor Model Rating Form (FFMRF) is a one-page measure designed to provide an efficient assessment of the higher order domains of the Five Factor Model (FFM) as well as the more specific, lower order facets proposed by McCrae and Costa. Although previous research has suggested that the FFMRF's assessment of the lower order facets converge…

  6. An Investigation of the Factor Structure and Convergent and Discriminant Validity of the Five-Factor Model Rating Form

    ERIC Educational Resources Information Center

    Samuel, Douglas B.; Mullins-Sweatt, Stephanie N.; Widiger, Thomas A.

    2013-01-01

    The Five-Factor Model Rating Form (FFMRF) is a one-page measure designed to provide an efficient assessment of the higher order domains of the Five Factor Model (FFM) as well as the more specific, lower order facets proposed by McCrae and Costa. Although previous research has suggested that the FFMRF's assessment of the lower order facets converge…

  7. Molecular analysis of the HEXA gene in Italian patients with infantile and late onset Tay-Sachs disease: detection of fourteen novel alleles.

    PubMed

    Montalvo, Anna Lisa E; Filocamo, Mirella; Vlahovicek, Kristian; Dardis, Andrea; Lualdi, Susanna; Corsolini, Fabio; Bembi, Bruno; Pittis, Maria Gabriela

    2005-09-01

    Tay-Sachs disease (TSD) is a recessively inherited disorder caused by the hexosaminidase A deficiency. We report the molecular characterization performed on 31 Italian patients, 22 with the infantile, acute form of TSD and nine patients with the subacute juvenile form, biochemically classified as B1 Variant. Of the 29 different alleles identified, fourteen were due to 15 novel mutations, two being in-cis on a new complex allele. The new alleles caused four frameshifts, three premature stop codons, three amino acid changes, two amino acid deletions and two splicing alterations. As previously reported, the c.533G>A (p.R178H) mutation was present either in homozygosity or as compound heterozygote, in all the patients with the late onset TSD form (B1 Variant); the allele frequency in this group is discussed by comparison with that found in infantile TSD.

  8. Interaction between droplets in a ternary microemulsion evaluated by the relative form factor method

    SciTech Connect

    Nagao, Michihiro; Seto, Hideki; Yamada, Norifumi L.

    2007-06-15

    This paper describes the concentration dependence of the interaction between water droplets coated by a surfactant monolayer using the contrast variation small-angle neutron scattering technique. In the first part, we explain the idea of how to extract a relatively model free structure factor from the scattering data, which is called the relative form factor method. In the second part, the experimental results for the shape of the droplets (form factor) are described. In the third part the relatively model free structure factor is shown, and finally the concentration dependence of the interaction potential between droplets is discussed. The result indicates the validity of the relative form factor method, and the importance of the estimation of the model free structure factor to discuss the nature of structure formation in microemulsion systems.

  9. Neurocognitive testing in late-onset Tay-Sachs disease: a pilot study.

    PubMed

    Elstein, D; Doniger, G M; Simon, E; Korn-Lubetzki, I; Navon, R; Zimran, A

    2008-08-01

    To test neurocognitive function in patients with late-onset Tay-Sachs disease (LOTS) using a computerized system to assess whether cognition is a clinically relevant outcome measure of possible therapeutic intervention in LOTS. Ten adults with Tay-Sachs disease were administered at least one battery of the Mindstreams Neurotrax system for evaluation of cognitive function. Six sub-scores and a Global Cognitive Score (GCS) were tabulated. A disease specific severity score was also devised with six domains. Despite identical genotypes, all patients but the two oldest had > or = 3/6 sub-scores one standard deviation below normal mean (100); verbal and executive functions were most affected. The severity score measured other functions. Because of provocative findings on re-testing in patients exposed to miglustat, and despite the very small cohort, cognitive function may be an appropriate and clinically relevant outcome measure for future therapeutic interventions in LOTS.

  10. Role of the physician in screening for carriers of Tay-Sachs disease.

    PubMed Central

    Lowden, J. A.

    1978-01-01

    A screening test for carriers of Tay-Sachs disease has been available in Toronto for more than 6 years. In that time more than 11 000 Jewish residents have been tested. Most had requested testing after hearing about the screening program from friends or the media; few had been advised by their physicians to be tested. To sample the attitudes of physicians in Toronto towards carrier screening, we studied questionnaire responses of 42 physicians whose practices were composed largely of Jewish patients. Only 31% regularly advised their young adult Jewish patients to have a carrier screening test but 76% said they had patients who asked if they should be tested. Of the 14 (33%) who had had one or more patients with Tay-Sachs disease 6 did not advise carrier testing. There was a positive correlation between specialty training and support for the screening program. Methods for increasing physician advocacy of these programs are discussed. PMID:709448

  11. Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin.

    PubMed

    Platt, F M; Neises, G R; Reinkensmeier, G; Townsend, M J; Perry, V H; Proia, R L; Winchester, B; Dwek, R A; Butters, T D

    1997-04-18

    The glycosphingolipid (GSL) lysosomal storage diseases result from the inheritance of defects in the genes encoding the enzymes required for catabolism of GSLs within lysosomes. A strategy for the treatment of these diseases, based on an inhibitor of GSL biosynthesis N-butyldeoxynojirimycin, was evaluated in a mouse model of Tay-Sachs disease. When Tay-Sachs mice were treated with N-butyldeoxynojirimycin, the accumulation of GM2 in the brain was prevented, with the number of storage neurons and the quantity of ganglioside stored per cell markedly reduced. Thus, limiting the biosynthesis of the substrate (GM2) for the defective enzyme (beta-hexosaminidase A) prevents GSL accumulation and the neuropathology associated with its lysosomal storage.

  12. Noncanonical phase-space noncommutativity and the Kantowski-Sachs singularity for black holes

    NASA Astrophysics Data System (ADS)

    Bastos, Catarina; Bertolami, Orfeu; Dias, Nuno Costa; Prata, João Nuno

    2011-07-01

    We consider a cosmological model based upon a noncanonical noncommutative extension of the Heisenberg-Weyl algebra to address the thermodynamical stability and the singularity problem of black holes whose interior are described by the Kantowski-Sachs metric and modeled by a noncommutative extension of the Wheeler-DeWitt equation. We compute the temperature and entropy of these black holes and compare the results with the Hawking values. We observe that it is actually the noncommutativity in the momentum sector that allows for the existence of a minimum in the potential, which is the key to apply the Feynman-Hibbs procedure. It is shown that this noncommutative model generates a nonunitary dynamics that predicts a vanishing probability in the neighborhood of the singularity. This result effectively regularizes the Kantowski-Sachs singularity and generalizes a similar result, previously obtained for the case of Schwarzschild black holes.

  13. CMB anisotropies at all orders: the non-linear Sachs-Wolfe formula

    NASA Astrophysics Data System (ADS)

    Roldan, Omar

    2017-08-01

    We obtain the non-linear generalization of the Sachs-Wolfe + integrated Sachs-Wolfe (ISW) formula describing the CMB temperature anisotropies. Our formula is valid at all orders in perturbation theory, is also valid in all gauges and includes scalar, vector and tensor modes. A direct consequence of our results is that the maps of the logarithmic temperature anisotropies are much cleaner than the usual CMB maps, because they automatically remove many secondary anisotropies. This can for instance, facilitate the search for primordial non-Gaussianity in future works. It also disentangles the non-linear ISW from other effects. Finally, we provide a method which can iteratively be used to obtain the lensing solution at the desired order.

  14. Electromagnetic form factors of Λb in the Bethe-Salpeter equation approach

    NASA Astrophysics Data System (ADS)

    Liu, Liang-Liang; Wang, Chao; Liu, Ying; Guo, Xin-Heng

    2017-03-01

    The heavy baryon Λb is regarded as composed of a heavy quark and a scalar diquark which has good spin and isospin quantum numbers. In this picture, we calculate the electromagnetic form factors of Λb in the Bethe-Salpeter equation approach in the spacelike region. We find that the shapes of the electromagnetic form factors of Λb are similar to those of Λ , with a peak at ω =1 (for the magnetic form factor) and ω ≃1.1 (for the electric form factor)(ω =v'.v is the velocity transfer between the initial state (with velocity v ) and the final state (with velocity v') of Λb), but the amplitudes are much smaller than those of Λ .

  15. Improving the phenomenology of K{sub l3} form factors with analyticity and unitarity

    SciTech Connect

    Abbas, Gauhar; Ananthanarayan, B.; Imsong, I. Sentitemsu; Caprini, Irinel

    2010-11-01

    The shape of the vector and scalar K{sub l3} form factors is investigated by exploiting analyticity and unitarity in a model-independent formalism. The method uses as input dispersion relations for certain correlators computed in perturbative QCD in the deep Euclidean region, soft-meson theorems, and experimental information on the phase and modulus of the form factors along the elastic part of the unitarity cut. We derive constraints on the coefficients of the parameterizations valid in the semileptonic range and on the truncation error. The method also predicts low-energy domains in the complex t plane where zeros of the form factors are excluded. The results are useful for K{sub l3} data analyses and provide theoretical underpinning for recent phenomenological dispersive representations for the form factors.

  16. ACOG committee opinion. Number 318, October 2005. Screening for Tay-Sachs disease.

    PubMed

    2005-10-01

    Tay-Sachs disease (TSD) is a severe progressive neurologic disease that causes death in early childhood. Carrier screening, should be offered before pregnancy to individuals and couples at high-risk, including those of Ashkenazi Jewish, French-Canadian, or Cajun descent and those with a family history consistent with TSD. If both partners are determined to be carriers of TSD, genetic counseling and prenatal diagnosis should be offered.

  17. The spin-dependent neutralino-nucleus form factor for {sup 127}I

    SciTech Connect

    Ressell, M.T.; Dean, D.J.

    1996-12-01

    We present the results of detailed shell model calculations of the spin-dependent elastic form factor for the nucleus {sup 127}I. the calculations were performed in extremely large model spaces which adequately describe the configuration mixing in this nucleus. Good agreement between the calculated and experimental values of the magnetic moment are found. Other nuclear observables are also compared to experiment. The dependence of the form factor upon the model space and effective interaction is discussed.

  18. Low-Q2 measurements of the proton form factor ratio μpGE/GM

    NASA Astrophysics Data System (ADS)

    Ron, G.; Zhan, X.; Glister, J.; Lee, B.; Allada, K.; Armstrong, W.; Arrington, J.; Beck, A.; Benmokhtar, F.; Berman, B. L.; Boeglin, W.; Brash, E.; Camsonne, A.; Calarco, J.; Chen, J. P.; Choi, Seonho; Chudakov, E.; Coman, L.; Craver, B.; Cusanno, F.; Dumas, J.; Dutta, C.; Feuerbach, R.; Freyberger, A.; Frullani, S.; Garibaldi, F.; Gilman, R.; Hansen, O.; Higinbotham, D. W.; Holmstrom, T.; Hyde, C. E.; Ibrahim, H.; Ilieva, Y.; de Jager, C. W.; Jiang, X.; Jones, M.; Kelleher, A.; Khrosinkova, E.; Kuchina, E.; Kumbartzki, G.; Lerose, J. J.; Lindgren, R.; Markowitz, P.; Beck, S. May-Tal; McCullough, E.; Meziane, M.; Meziani, Z.-E.; Michaels, R.; Moffit, B.; Norum, B. E.; Oh, Y.; Olson, M.; Paolone, M.; Paschke, K.; Perdrisat, C. F.; Piasetzky, E.; Potokar, M.; Pomatsalyuk, R.; Pomerantz, I.; Puckett, A. J. R.; Punjabi, V.; Qian, X.; Qiang, Y.; Ransome, R.; Reyhan, M.; Roche, J.; Rousseau, Y.; Saha, A.; Sarty, A. J.; Sawatzky, B.; Schulte, E.; Shabestari, M.; Shahinyan, A.; Shneor, R.; Širca, S.; Slifer, K.; Solvignon, P.; Song, J.; Sparks, R.; Subedi, R.; Strauch, S.; Urciuoli, G. M.; Wang, K.; Wojtsekhowski, B.; Yan, X.; Yao, H.; Zhu, X.

    2011-11-01

    We present an updated extraction of the proton electromagnetic form factor ratio, μpGE/GM, at low Q2. The form factors are sensitive to the spatial distribution of the proton, and precise measurements can be used to constrain models of the proton. An improved selection of the elastic events and reduced background contributions yielded a small systematic reduction in the ratio μpGE/GM compared to the original analysis.

  19. Form factors with q 2 = 0 and Grassmannians in N = 4 Sym theory

    NASA Astrophysics Data System (ADS)

    Bork, L. V.; Onishchenko, A. I.

    2017-09-01

    In this note we consider tree level form factors of operators from stress tensor supermultiplet with light like operator momentum q 2 = 0. The presentation of form factors in terms of the regulated integral over Grassmannian is given. The conjectured formula is verified by successfully reproducing known answers in the MHV and N k-2MHV, k ≥ 3 sectors as well as appropriate soft limit behavior.

  20. Interpreting the neutron's electric form factor: Rest frame charge distribution or foldy term?

    SciTech Connect

    Nathan Isgur

    1998-12-01

    The neutron's electric form factor contains vital information on nucleon structure, but its interpretation within many models has been obscured by relativistic effects. The author demonstrates that, to leading order in the relativistic expansion of a constituent quark model, the Foldy term cancels exactly against a contribution to the Dirac form factor F{sub 1} to leave intact the naive interpretation of G{sup n}{sub E} as arising from the neutron's rest frame charge distribution.

  1. Nucleon-to-{delta} axial transition form factors in relativistic baryon chiral perturbation theory

    SciTech Connect

    Geng, L. S.; Camalich, J. Martin; Alvarez-Ruso, L.; Vacas, M. J. Vicente

    2008-07-01

    We report a theoretical study of the axial nucleon-to-delta (1232) (N{yields}{delta}) transition form factors up to one-loop order in relativistic baryon chiral perturbation theory. We adopt a formalism in which the {delta} couplings obey the spin-3/2 gauge symmetry and, therefore, decouple the unphysical spin-1/2 fields. We compare the results with phenomenological form factors obtained from neutrino bubble-chamber data and in quark models.

  2. Deuteron electromagnetic form factors in a renormalizable formulation of chiral effective field theory

    NASA Astrophysics Data System (ADS)

    Epelbaum, E.; Gasparyan, A. M.; Gegelia, J.; Schindler, M. R.

    2014-03-01

    We calculate the deuteron electromagnetic form factors in a modified version of Weinberg's chiral effective field theory approach to the two-nucleon system. We derive renormalizable integral equations for the deuteron without partial wave decomposition. Deuteron form factors are extracted by applying the Lehmann-Symanzik-Zimmermann reduction formalism to the three-point correlation function of deuteron interpolating fields and the electromagnetic current operator. Numerical results of a leading-order calculation with removed cutoff regularization agree well with experimental data.

  3. Proton electromagnetic form factors: present status and future perspectives at PANDA

    NASA Astrophysics Data System (ADS)

    Tomasi-Gustafsson, E.

    2015-05-01

    Data and models on electromagnetic proton form factors are reviewed, highlighting the contribution foreseen by the PANDA collaboration. Electromagnetic hadron form factors contain essential information on the internal structure of hadrons. Precise and surprising data have been obtained at electron accelerators, applying the polarization method in electron-proton elastic scattering. At electron-positron colliders, using initial state radiation, BABAR measured proton time-like form factors in a wide time-like kinematical region and the BESIII collaboration will measure very precisely proton and neutron form factors in the threshold region. In the next future an antiproton beam with momentum up to 15 GeV/c will be available at FAIR (Darmstadt). Measurements of the reaction p̅ + p → e+ + e- by the PANDA collaboration will contribute to the individual determination of electric and magnetic form factors in the time-like region of momentum transfer squared, as well as to their first determination in the unphysical region (below the kinematical threshold), through the reaction p̅ + p → e+ + e- + π0. From the discussion on feasibility studies at PANDA, we focus on the consequences of such measurements in view of an unified description of form factors in the full kinematical region. We present models which have the necessary analytical requirements and apply to the data in the whole kinematical region.

  4. $$B\\to Kl^+l^-$$ decay form factors from three-flavor lattice QCD

    DOE PAGES

    Bailey, Jon A.

    2016-01-27

    We compute the form factors for the B → Kl+l- semileptonic decay process in lattice QCD using gauge-field ensembles with 2+1 flavors of sea quark, generated by the MILC Collaboration. The ensembles span lattice spacings from 0.12 to 0.045 fm and have multiple sea-quark masses to help control the chiral extrapolation. The asqtad improved staggered action is used for the light valence and sea quarks, and the clover action with the Fermilab interpretation is used for the heavy b quark. We present results for the form factors f+(q2), f0(q2), and fT(q2), where q2 is the momentum transfer, together with a comprehensivemore » examination of systematic errors. Lattice QCD determines the form factors for a limited range of q2, and we use the model-independent z expansion to cover the whole kinematically allowed range. We present our final form-factor results as coefficients of the z expansion and the correlations between them, where the errors on the coefficients include statistical and all systematic uncertainties. Lastly, we use this complete description of the form factors to test QCD predictions of the form factors at high and low q2.« less

  5. Effects of core deformations and collective rotational currents on electron-nucleus magnetic form factors

    SciTech Connect

    Lin, C.K.

    1983-01-01

    The collective model H/sub int/ + H/sub coll/ is used to study the magnetic form factors. For the intrinsic Hamiltonian, we use the Nilsson model to generate the intrinsic state. For the collective Hamiltonian, two models are considered, the rigid body model and the liquid soap model. We use the particle-rotor model to derive the collective operators and their reduced matrix elements, and then apply this model to the elastic M1 form factor of /sup 13/C. One sees clearly the interplay of the intrinsic form factor and the collective form factor. Since the form factor is essentially a Fourier transform of the current density operator, one also sees the effects of the collective current density distribution due to all the particles in addition to that of the intrinsic current due to the unpaired nucleons. The effects of core deformation are explored. This includes discussions on the difference between the variation before projection and the variation after projection. Analytic results are obtained in the case of weak deformations. The collective model focuses on the effects of the quadrupole deformation on the M1 form factor of /sup 13/C, whereas the calculation involving core polarization stresses the monopole effects. By introducing a quenching of the isovector g/sub s/, the fits by the collective models are very comparable to the fit by the core polarization, although the justification for this procedure in light nuclei is questionable.

  6. Mixed-state form factors of U(1) twist fields in the Dirac theory

    NASA Astrophysics Data System (ADS)

    Chen, Yixiong

    2016-08-01

    Using the ‘Liouville space’ (the space of operators) of the massive Dirac theory, we define mixed-state form factors of U(1) twist fields. We consider mixed states with density matrices diagonal in the asymptotic particle basis. This includes the thermal Gibbs state as well as all generalized Gibbs ensembles of the Dirac theory. When the mixed state is specialized to a thermal Gibbs state, using a Riemann-Hilbert problem and low-temperature expansion, we obtain finite-temperature form factors of U(1) twist fields. We then propose the expression for form factors of U(1) twist fields in general diagonal mixed states. We verify that these form factors satisfy a system of nonlinear functional differential equations, which is derived from the trace definition of mixed-state form factors. At last, under weak analytic conditions on the eigenvalues of the density matrix, we write down the large distance form factor expansions of two-point correlation functions of these twist fields. Using the relation between the Dirac and Ising models, this provides the large-distance expansion of the Rényi entropy (for integer Rényi parameter) in the Ising model in diagonal mixed states.

  7. $B\\to Kl^+l^-$ decay form factors from three-flavor lattice QCD

    SciTech Connect

    Bailey, Jon A.

    2016-01-27

    We compute the form factors for the B → Kl+l- semileptonic decay process in lattice QCD using gauge-field ensembles with 2+1 flavors of sea quark, generated by the MILC Collaboration. The ensembles span lattice spacings from 0.12 to 0.045 fm and have multiple sea-quark masses to help control the chiral extrapolation. The asqtad improved staggered action is used for the light valence and sea quarks, and the clover action with the Fermilab interpretation is used for the heavy b quark. We present results for the form factors f+(q2), f0(q2), and fT(q2), where q2 is the momentum transfer, together with a comprehensive examination of systematic errors. Lattice QCD determines the form factors for a limited range of q2, and we use the model-independent z expansion to cover the whole kinematically allowed range. We present our final form-factor results as coefficients of the z expansion and the correlations between them, where the errors on the coefficients include statistical and all systematic uncertainties. Lastly, we use this complete description of the form factors to test QCD predictions of the form factors at high and low q2.

  8. Correlation of augmented startle reflex with brainstem electrophysiological responses in Tay-Sachs disease.

    PubMed

    Nakamura, Sadao; Saito, Yoshiaki; Ishiyama, Akihiko; Sugai, Kenji; Iso, Takashi; Inagaki, Masumi; Sasaki, Masayuki

    2015-01-01

    To clarify the evolution of an augmented startle reflex in Tay-Sachs disease and compare the temporal relationship between this reflex and brainstem evoked potentials. Clinical and electrophysiological data from 3 patients with Tay-Sachs disease were retrospectively collected. The augmented startle reflex appeared between the age of 3 and 17 months and disappeared between the age of 4 and 6 years. Analysis of brainstem auditory evoked potentials revealed that poor segregation of peak I, but not peak III, coincided with the disappearance of the augmented startle reflex. A blink reflex with markedly high amplitude was observed in a patient with an augmented startle reflex. The correlation between the augmented startle reflex and the preservation of peak I but not peak III supports the theory that the superior olivary nucleus is dispensable for this reflex. The blink reflex with high amplitudes may represent augmented excitability of reticular formation at the pontine tegmentum in Tay-Sachs disease, where the pattern generators for the augmented startle and blink reflexes may functionally overlap. Copyright © 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  9. Lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease

    PubMed Central

    Kodama, Takashi; Togawa, Tadayasu; Tsukimura, Takahiro; Kawashima, Ikuo; Matsuoka, Kazuhiko; Kitakaze, Keisuke; Tsuji, Daisuke; Itoh, Kohji; Ishida, Yo-ichi; Suzuki, Minoru; Suzuki, Toshihiro; Sakuraba, Hitoshi

    2011-01-01

    To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease. PMID:22205997

  10. 77 FR 4227 - Implantation or Injectable Dosage Form New Animal Drugs; Gonadotropin Releasing Factor Analog...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 522 Implantation or Injectable Dosage Form New... gonadotropin releasing factor analog-diphtheria toxoid conjugate injectable solution. DATES: This rule is...: PART 522--IMPLANTATION OR INJECTABLE DOSAGE FORM NEW ANIMAL DRUGS 0 1. The authority citation for...

  11. Form and structure factors for impedance and reflection from periodic layers.

    PubMed

    Pan, Janet L

    2007-01-20

    In an exact treatment of the Maxwell equations, we derive form and structure factors for reflection from periodic layers, and we show that these factors are significantly different from their analogs in kinematic x-ray diffraction. Quite generally, we show that reflection and impedance can be written precisely as the sum of an additive form factor and the product of a structure factor and a second form factor. This additive form factor does not have an analog in kinematic x-ray diffraction. It is demonstrated that the form factors are found by analytic continuation to an arbitrary wavelength of expressions for the impedance both at long wavelengths and at quarter wavelengths. A correction to the Bragg law relating fringe spacing to the total structure thickness is derived. We go beyond previous numerical work by deriving simple analytic exact expressions for reflection and impedance of periodic layers for all frequencies within the reflection passband, and for an arbitrary number of periods in the structure, an arbitrary index profile within each period, arbitrary layer thicknesses (not just quarter-wave layers), and for arbitrary sizes of the refractive index differences.

  12. Pure sea-quark contributions to the magnetic form factors of Σ baryons

    NASA Astrophysics Data System (ADS)

    Wang, P.; Leinweber, D. B.; Thomas, A. W.

    2015-08-01

    We propose the pure sea-quark contributions to the magnetic form factors of Σ baryons, GΣ-u and GΣ+d,as priority observables for the examination of sea-quark contributions to baryon structure, both in present lattice QCD simulations and possible future experimental measurement. GΣ-u, the u -quark contribution to the magnetic form factor of Σ-,and GΣ+d, the d -quark contribution to the magnetic form factor of Σ+,are similar to the strange-quark contribution to the magnetic form factor of the nucleon, but promise to be larger by an order of magnitude. We explore the size of this quantity within chiral effective field theory, including both octet and decuplet intermediate states. The finite range regularization approach is applied to deal with ultraviolet divergences. Drawing on an established connection between quenched and full QCD, this approach makes it possible to predict the sea-quark contribution to the magnetic form factor purely from the meson loop. In the familiar convention where the quark charge is set to unity GΣ-u=GΣ+d. We find a value of -0.38-0.17+0.16 μN , which is about seven times larger than the strange magnetic moment of the nucleon found in the same approach. Including quark charge factors, the u -quark contribution to the Σ- magnetic moment exceeds the strange-quark contribution to the nucleon magnetic moment by a factor of 14.

  13. Human transforming growth factor. beta. -. cap alpha. /sub 2/-macroglobulin complex is a latent form of transforming growth factor. beta

    SciTech Connect

    Huang, S.S.; O'Grady, P.; Huang, J.S.

    1987-05-01

    Human platelet-derived transforming growth factor ..beta.. (TGF..beta..) has been shown to be present as a high molecular weight latent form in human serum. Appearance of transforming growth factor activity, along with the change from high molecular weight form to low molecular weight form, was observed following treatment of the latent form of TGF..beta.. with acid or urea, suggesting that the latent form of TGF..beta.. is a complex of TGF..beta.. and a high molecular weight binding protein. Human ..cap alpha../sub 2/-M has been found to be a plasma binding protein for platelet-derived growth factor (PDGF) in serum or plasma. TGF..beta.. and PDGF share similar properties. They, therefore, investigated the interaction between /sup 125/I-TGF..beta.. and ..cap alpha../sub 2/M. /sup 125/I-TGF..beta.. and purified human ..cap alpha../sub 2/M formed a complex as demonstrated by polyacrylamide gel electrophoresis. Most of the /sup 125/I-TGF..beta..-..cap alpha../sub 2/M complex could be dissociated by acid or urea treatment. These results suggest that ..cap alpha../sub 2/M is a binding protein for TGF..beta.. and that TGF..beta..-..cap alpha../sub 2/M complex may be the latent form of TGF..beta.. in serum.

  14. Charged pion form factor between $Q^2$=0.60 and 2.45 GeV$^2$. II. Determination of, and results for, the pion form factor

    SciTech Connect

    Huber, Garth; Blok, Henk; Horn, Tanja; Beise, Elizabeth; Gaskell, David; Mack, David; Tadevosyan, Vardan; Volmer, Jochen; Abbott, David; Aniol, Konrad; Anklin, Heinz; Armstrong, Christopher; Arrington, John; Assamagan, Ketevi; Avery, Steven; Baker, O.; Barrett, Robert; Bochna, Christopher; Boeglin, Werner; Brash, Edward; Breuer, Herbert; Chang, C.; Chang, C.C.; Chant, Nicholas; Christy, Michael; Dunne, James; Eden, Thomas; Ent, Rolf; Fenker, Benjamin; Gibson, Edward; Gilman, Ronald; Gustafsson, Kenneth; Hinton, Wendy; Holt, Roy; Jackson, Harold; uk Jin, Seong; Jones, Mark; Keppel, Cynthia; Kim, pyunghun; Kim, Wooyoung; King, Paul; Klein, Andreas; Koltenuk, Douglas; Kovaltchouk, Vitali; Liang, Meihua; Liu, Jinghua; Lolos, George; Lung, Allison; Margaziotis, Demetrius; Markowitz, Pete; Matsumura, Akihiko; McKee, David; Meekins, David; Mitchell, Joseph; Miyoshi, Toshinobu; Mkrtchyan, Hamlet; Mueller, Robert; Niculescu, Gabriel; Niculescu, Maria-Ioana; Okayasu, Yuichi; Pentchev, Lubomir; Perdrisat, Charles; Pitz, David; Potterveld, David; Punjabi, Vina; Qin, Liming; Reimer, Paul; Reinhold, Joerg; Roche, Julie; Roos, Philip; Sarty, Adam; Shin, Ilkyoung; Smith, Gregory; Stepanyan, Stepan; Tang, Liguang; Tvaskis, Vladas; van der Meer, Rob; Vansyoc, Kelley; Van Westrum, Derek; Vidakovic, Sandra; Vulcan, William; Warren, Glen; Wood, Stephen; Xu, Chen; Yan, Chen; Zhao, Wenxia; Zheng, Xiaochao; Zihlmann, Benedikt

    2008-10-01

    DOI: http://dx.doi.org/10.1103/PhysRevC.78.045203
    The charged pion form factor, Fpi(Q2), is an important quantity that can be used to advance our knowledge of hadronic structure. However, the extraction of Fpi from data requires a model of the 1H(e,e'pi+)n reaction and thus is inherently model dependent. Therefore, a detailed description of the extraction of the charged pion form factor from electroproduction data obtained recently at Jefferson Lab is presented, with particular focus given to the dominant uncertainties in this procedure. Results for Fpi are presented for Q2=0.60-2.45 GeV2. Above Q2=1.5 GeV2, the Fpi values are systematically below the monopole parametrization that describes the low Q2 data used to determine the pion charge radius. The pion form factor can be calculated in a wide variety of theoretical approaches, and the experimental results are compared to a number of calculations. This comparison is helpful in understanding the role of soft versus hard c

  15. Differences between poliovirus empty capsids formed in vivo and those formed in vitro: a role for the morphopoietic factor.

    PubMed Central

    Putnak, J R; Phillips, B A

    1981-01-01

    Empty capsid species formed from the self- and extract-mediated assembly of poliovirus type 1 14S particles in vitro and procapsids isolated from virus-infected cells were subjected to isoelectric focusing in charge-free agarose gels. The empty capsid formed in the self-assembly reaction had an isoelectric point (pI) of 5.0, whereas procapsids and extract-assembled empty capsids focused at pH 6.8. Unreacted 14S particles focused at pH 4.8 to 5.0. The sedimentation coefficient (s20,w) and density of the empty capsid species were also determined. Procapsids had a density in CsCl of 1.31 g/cm3, whereas empty capsids formed by self- or extract-mediated assembly had a density of 1.29 g/cm3. Both extract-assembled empty capsids and procapsids had an s20,w of 75S, whereas self-assembled empty capsids had an s20,w of 71S. Self-assembled empty capsids were not converted to pI 6.8 empty capsids by incubation with poliovirus-infected HeLa cell extracts. The dissociated polypeptides of self-assembled empty capsids (pI 5.0) and procapsids (pI 6.8) behaved identically when analyzed by isoelectric focusing in the presence of 9 M urea and by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. These results suggest that infected cell extracts possess a factor that influences the final conformation of the empty shell (pI 6.8, 75S) formed from 14S particles and that this influences is exerted at the initiation step or during the polymerization reaction. A small amount of this activity (less than or equal to 20% of infected extracts) was detected in uninfected cells; the significance of this remains unknown. Images PMID:6270373

  16. Multilevel Confirmatory Factor Analysis of the Teacher My Class Inventory-Short Form

    ERIC Educational Resources Information Center

    Villares, Elizabeth; Mariani, Melissa; Sink, Christopher A.; Colvin, Kimberly

    2016-01-01

    Researchers analyzed data from elementary teachers (N = 233) to further establish the psychometric soundness of the Teacher My Class Inventory-Short Form. Supporting previous psychometric research, confirmatory factor analyses findings supported the factorial validity of the hypothesized five-factor solution. Internal reliability estimates were…

  17. Factor Structure and Psychometric Properties of the Young Schema Questionnaire (Short Form) in Chinese Undergraduate Students

    ERIC Educational Resources Information Center

    Cui, Lixia; Lin, Wenwen; Oei, Tian P. S.

    2011-01-01

    This study investigated cross-cultural differences in the factor structure and psychometric properties of the Young Schema Questionnaire (short form; YSQ-SF). The participants were 712 Chinese undergraduate students. The total sample was randomly divided into two sub-samples. Exploratory Factor Analysis (EFA) was conducted on questionnaire results…

  18. Factor Structure and Validity of the Parenting Stress Index-Short Form

    ERIC Educational Resources Information Center

    Haskett, Mary E.; Ahern, Lisa S.; Ward, Caryn S.; Allaire, Jason C.

    2006-01-01

    The psychometric properties of the Parenting Stress Index-Short Form (PSI-SF) were examined in a sample of 185 mothers and fathers. Factor analysis revealed 2 reasonably distinct factors involving parental distress and dysfunctional parent-child interactions. Both scales were internally consistent, and these scales were correlated with measures of…

  19. Multilevel Confirmatory Factor Analysis of the Teacher My Class Inventory-Short Form

    ERIC Educational Resources Information Center

    Villares, Elizabeth; Mariani, Melissa; Sink, Christopher A.; Colvin, Kimberly

    2016-01-01

    Researchers analyzed data from elementary teachers (N = 233) to further establish the psychometric soundness of the Teacher My Class Inventory-Short Form. Supporting previous psychometric research, confirmatory factor analyses findings supported the factorial validity of the hypothesized five-factor solution. Internal reliability estimates were…

  20. Forms, Factors and Consequences of Cheating in University Examinations: Insight from Open and Distance Learning Students

    ERIC Educational Resources Information Center

    Mokula, Lebeloane Lazarus Donald; Lovemore, Nyaumwe

    2014-01-01

    The present study narrated the forms, factors and consequences of cheating in university examinations by UNISA Open and Distance learning students from anecdotal data. The results showed that the perpetrators mostly used crib materials on paper, ruler and calculator cover. The factors that influenced examination cheating were gender, age range and…

  1. Density form factors of the 1D Bose gas for finite entropy states

    NASA Astrophysics Data System (ADS)

    De Nardis, J.; Panfil, M.

    2015-02-01

    We consider the Lieb-Liniger model for a gas of bosonic δ-interacting particles. Using Algebraic Bethe Ansatz results we compute the thermodynamic limit of the form factors of the density operator between finite entropy eigenstates such as finite temperature states or generic non-equilibrium highly excited states. These form factors are crucial building blocks to obtain the thermodynamic exact dynamic correlation functions of such physically relevant states. As a proof of principle we compute an approximated dynamic structure factor by including only the simplest types of particle-hole excitations and show the agreement with known results.

  2. B to tensor meson form factors in the perturbative QCD approach

    SciTech Connect

    Wang Wei

    2011-01-01

    We calculate the B{sub u,d,s}{yields}T form factors within the framework of the perturbative QCD approach, where T denotes a light tensor meson with J{sup P}=2{sup +}. Because of the similarities between the wave functions of a vector and a tensor meson, the factorization formulas of B{yields}T form factors can be obtained from the B{yields}V transition through a replacement rule. As a consequence, we find that these two sets of form factors have the same signs and correlated q{sup 2}-dependence behaviors. At q{sup 2}=0 point, the B{yields}T form factors are smaller than the B{yields}V ones, in accordance with the experimental data of radiative B decays. In addition, we use our results for the form factors to explore semilteptonic B{yields}Tl{nu}{sub l} decays and the branching fractions can reach the order 10{sup -4}.

  3. Form factor effects in the direct detection of isospin-violating dark matter

    SciTech Connect

    Zheng, Hao; Zhang, Zhen; Chen, Lie-Wen E-mail: malkuth@sjtu.edu.cn

    2014-08-01

    Isospin-violating dark matter (IVDM) provides a possible mechanism to ameliorate the tension among recent direct detection experiments. For IVDM, we demonstrate that the results of direct detection experiments based on neutron-rich target nuclei may depend strongly on the density dependence of the symmetry energy which is presently largely unknown and controls the neutron skin thickness that reflects the relative difference of neutron and proton form factors in the neutron-rich nuclei. In particular, using the neutron and proton form factors obtained from Skyrme-Hartree-Fock calculations by varying the symmetry energy within the uncertainty region set by the latest model-independent measurement of the neutron skin thickness of {sup 208}Pb from PREX experiment at JLab, we find that, for IVDM with neutron-to-proton coupling ratio fixed to f{sub n}/f{sub p}=-0.7, the form factor effect may enhance the sensitivity of Xe-based detectors (e.g., XENON100 and LUX) to the DM-proton cross section by a factor of 3 in the DM mass region constrained by CMDS-II(Si) and even by more than an order of magnitude for heavy DM with mass larger than 80 GeV, compared with the results using the empirical Helm form factor. Our results further indicate that the form factor effect can significantly modify the recoil spectrum of Xe-based detectors for heavy IVDM with f{sub n}/f{sub p}=-0.7.

  4. Form factor effects in the direct detection of isospin-violating dark matter

    NASA Astrophysics Data System (ADS)

    Zheng, Hao; Zhang, Zhen; Chen, Lie-Wen

    2014-08-01

    Isospin-violating dark matter (IVDM) provides a possible mechanism to ameliorate the tension among recent direct detection experiments. For IVDM, we demonstrate that the results of direct detection experiments based on neutron-rich target nuclei may depend strongly on the density dependence of the symmetry energy which is presently largely unknown and controls the neutron skin thickness that reflects the relative difference of neutron and proton form factors in the neutron-rich nuclei. In particular, using the neutron and proton form factors obtained from Skyrme-Hartree-Fock calculations by varying the symmetry energy within the uncertainty region set by the latest model-independent measurement of the neutron skin thickness of 208Pb from PREX experiment at JLab, we find that, for IVDM with neutron-to-proton coupling ratio fixed to fn/fp=-0.7, the form factor effect may enhance the sensitivity of Xe-based detectors (e.g., XENON100 and LUX) to the DM-proton cross section by a factor of 3 in the DM mass region constrained by CMDS-II(Si) and even by more than an order of magnitude for heavy DM with mass larger than 80 GeV, compared with the results using the empirical Helm form factor. Our results further indicate that the form factor effect can significantly modify the recoil spectrum of Xe-based detectors for heavy IVDM with fn/fp=-0.7.

  5. A study of the γ ^*-f0(980) transition form factors

    NASA Astrophysics Data System (ADS)

    Kroll, P.

    2017-02-01

    The γ ^*-f0(980) transition form factors are calculated within the QCD factorization framework. The f_0-meson is assumed to be mainly generated through its sbar{s} Fock component. The corresponding spin wave function of the f0(980) meson is constructed and, combined with a model light-cone wave function for this Fock component, used in the calculation of the form factors. In the real-photon limit the results for the transverse form factor are compared to the large momentum-transfer data measured by the BELLE collaboration recently. It turns out that, for the momentum-transfer range explored by BELLE, the collinear approximation does not suffice, power corrections to it, modeled as quark transverse moment effects, seem to be needed. Mixing of the f_0 with the σ (500) is also briefly discussed.

  6. Factor structure of the BASC-2 Behavioral and Emotional Screening System Student Form.

    PubMed

    Dowdy, Erin; Twyford, Jennifer M; Chin, Jenna K; DiStefano, Christine A; Kamphaus, Randy W; Mays, Kristen L

    2011-06-01

    The BASC-2 Behavioral and Emotional Screening System (BESS) Student Form (Kamphaus & Reynolds, 2007) is a recently developed youth self-report rating scale designed to identify students at risk for behavioral and emotional problems. The BESS Student Form was derived from the Behavior Assessment System for Children-Second Edition Self-Report of Personality (BASC-2 SRP; Reynolds & Kamphaus, 2004) using principal component analytic procedures and theoretical considerations. Using 3 samples, the authors conducted exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) to understand the underlying factor structure of the BESS Student Form. The results of the EFA suggested that the SRP contained a 4-factor (i.e., Personal Adjustment, Inattention/Hyperactivity, Internalizing, School Problems) emergent structure, which was supported by CFA in 2 additional samples. Practical and research implications are discussed.

  7. Regularization of multi-soliton form factors in sine-Gordon model

    NASA Astrophysics Data System (ADS)

    Pálmai, T.

    2012-08-01

    A general and systematic regularization is developed for the exact solitonic form factors of exponential operators in the (1+1)-dimensional sine-Gordon model by analytical continuation of their integral representations. The procedure is implemented in Mathematica. Test results are shown for four- and six-soliton form factors. Catalogue identifier: AEMG_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEMG_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 1462 No. of bytes in distributed program, including test data, etc.: 15 488 Distribution format: tar.gz Programming language: Mathematica [1] Computer: PC Operating system: Cross-platform Classification: 7.7, 11.1, 23 Nature of problem: The multi-soliton form factors of the sine-Gordon model (relevant in two-dimensional physics) were given only by highly non-trivial integral representation with a limited domain of convergence. Practical applications of the form factors, e.g. calculation of correlation functions in two-dimensional condensed matter systems, were not possible in general. Solution method: Using analytic continuation techniques an efficient algorithm is found and implemented in Mathematica, which provides a general and systematic way to calculate multi-soliton form factors in the sine-Gordon model. The package contains routines to compute the two-, four- and six-soliton form factors. Running time: Strongly dependent on the desired accuracy and the number of solitons. For physical rapidities after an initialization of about 30 s, the calculation of the two-, four- and six-soliton form factors at a single point takes approximately 0.5 s, 2.5 s and 8 s, respectively. Wolfram Research, Inc., Mathematica Edition: Version 7.0, Wolfram Research, Inc., Champaign, Illinois, 2008.

  8. Flavor dependence of the pion and kaon form factors and parton distribution functions

    DOE PAGES

    Hutauruk, Parada T. P.; Cloët, Ian C.; Thomas, Anthony W.

    2016-09-01

    The separate quark flavor contributions to the pion and kaon valence quark distribution functions are studied, along with the corresponding electromagnetic form factors in the space-like region. The calculations are made using the solution of the Bethe-Salpeter equation for the model of Nambu and Jona-Lasinio with proper-time regularization. Both the pion and kaon form factors and the valence quark distribution functions reproduce many features of the available empirical data. The larger mass of the strange quark naturally explains the empirical fact that the ratio u(K) + (x)/u(pi) + (x) drops below unity at large x, with a value of approximately Mmore » $$2\\atop{u}$$/Ms$$2\\atop{s}$$ as x → 1. With regard to the elastic form factors we report a large flavor dependence, with the u-quark contribution to the kaon form factor being an order of magnitude smaller than that of the s-quark at large Q2, which may be a sensitive measure of confinement effects in QCD. Surprisingly though, the total K+ and π+ form factors differ by only 10%. Lastly, in general we find that flavor breaking effects are typically around 20%.« less

  9. Flavor dependence of the pion and kaon form factors and parton distribution functions

    SciTech Connect

    Hutauruk, Parada T. P.; Cloët, Ian C.; Thomas, Anthony W.

    2016-09-01

    The separate quark flavor contributions to the pion and kaon valence quark distribution functions are studied, along with the corresponding electromagnetic form factors in the space-like region. The calculations are made using the solution of the Bethe-Salpeter equation for the model of Nambu and Jona-Lasinio with proper-time regularization. Both the pion and kaon form factors and the valence quark distribution functions reproduce many features of the available empirical data. The larger mass of the strange quark naturally explains the empirical fact that the ratio u(K) + (x)/u(pi) + (x) drops below unity at large x, with a value of approximately M$2\\atop{u}$/Ms$2\\atop{s}$ as x → 1. With regard to the elastic form factors we report a large flavor dependence, with the u-quark contribution to the kaon form factor being an order of magnitude smaller than that of the s-quark at large Q2, which may be a sensitive measure of confinement effects in QCD. Surprisingly though, the total K+ and π+ form factors differ by only 10%. Lastly, in general we find that flavor breaking effects are typically around 20%.

  10. The puzzle of the π → γ γ* transition form factor

    NASA Astrophysics Data System (ADS)

    Lucha, Wolfgang; Melikhov, Dmitri

    2012-04-01

    We study the P → γ γ* (P = π0, η, η‧) transition form factors by means of the local-duality (LD) version of QCD sum rules. For the case of η and η‧, the conventional LD model provides a good description of the existing data. However, for the pion form factor we find a disagreement with recent BaBar results for high Q2, even though the accuracy of the LD approximation is expected to increase with Q2. It remains mysterious why both η and η‧ form factors to virtual photons, on the one hand, and the π0 form factor, on the other hand, show a qualitatively different behaviour, corresponding to a violation of LD that rises with Q2 in the pion case. In a quantum-mechanical example, we show that, for a bound-state size of about 1 fm, the LD sum rule provides an accurate prediction for the form factor for Q2 larger than a few GeV2.

  11. Tay–Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum–associated degradation

    PubMed Central

    Dersh, Devin; Iwamoto, Yuichiro; Argon, Yair

    2016-01-01

    Loss of function of the enzyme β-hexosaminidase A (HexA) causes the lysosomal storage disorder Tay–Sachs disease (TSD). It has been proposed that mutations in the α chain of HexA can impair folding, enzyme assembly, and/or trafficking, yet there is surprisingly little known about the mechanisms of these potential routes of pathogenesis. We therefore investigated the biosynthesis and trafficking of TSD-associated HexA α mutants, seeking to identify relevant cellular quality control mechanisms. The α mutants E482K and G269S are defective in enzymatic activity, unprocessed by lysosomal proteases, and exhibit altered folding pathways compared with wild-type α. E482K is more severely misfolded than G269S, as observed by its aggregation and inability to associate with the HexA β chain. Importantly, both mutants are retrotranslocated from the endoplasmic reticulum (ER) to the cytosol and are degraded by the proteasome, indicating that they are cleared via ER-associated degradation (ERAD). Leveraging these discoveries, we observed that manipulating the cellular folding environment or ERAD pathways can alter the kinetics of mutant α degradation. Additionally, growth of patient fibroblasts at a permissive temperature or with chemical chaperones increases cellular Hex activity by improving mutant α folding. Therefore modulation of the ER quality control systems may be a potential therapeutic route for improving some forms of TSD. PMID:27682588

  12. Tay-Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum-associated degradation.

    PubMed

    Dersh, Devin; Iwamoto, Yuichiro; Argon, Yair

    2016-12-01

    Loss of function of the enzyme β-hexosaminidase A (HexA) causes the lysosomal storage disorder Tay-Sachs disease (TSD). It has been proposed that mutations in the α chain of HexA can impair folding, enzyme assembly, and/or trafficking, yet there is surprisingly little known about the mechanisms of these potential routes of pathogenesis. We therefore investigated the biosynthesis and trafficking of TSD-associated HexA α mutants, seeking to identify relevant cellular quality control mechanisms. The α mutants E482K and G269S are defective in enzymatic activity, unprocessed by lysosomal proteases, and exhibit altered folding pathways compared with wild-type α. E482K is more severely misfolded than G269S, as observed by its aggregation and inability to associate with the HexA β chain. Importantly, both mutants are retrotranslocated from the endoplasmic reticulum (ER) to the cytosol and are degraded by the proteasome, indicating that they are cleared via ER-associated degradation (ERAD). Leveraging these discoveries, we observed that manipulating the cellular folding environment or ERAD pathways can alter the kinetics of mutant α degradation. Additionally, growth of patient fibroblasts at a permissive temperature or with chemical chaperones increases cellular Hex activity by improving mutant α folding. Therefore modulation of the ER quality control systems may be a potential therapeutic route for improving some forms of TSD.

  13. Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain.

    PubMed

    Li, Yu-Teh; Maskos, Karol; Chou, Chau-Wen; Cole, Richard B; Li, Su-Chen

    2003-09-12

    Tay-Sachs disease (TSD) is a classical glycosphingolipid (GSL) storage disease. Although the genetic and biochemical bases for a massive cerebral accumulation of ganglioside GM2 in TSD have been well established, the mechanism for the neural dysfunction in TSD remains elusive. Upon analysis of GSLs from a variant B TS brain, we have detected a novel GSL that has not been previously revealed. We have isolated this GSL in pure form. Using NMR spectroscopy, mass spectrometry, and chemical synthesis, the structure of this unusual GSL was established to be a taurine-conjugated GM2 (tauro-GM2) in which the carboxyl group of N-acetylneuraminic acid was amidated by taurine. Using a rabbit anti-tauro-GM2 serum, we also detected the presence of tauro-GM2 in three other small brain samples from one variant B and two variant O TSD patients. On the other hand, tauro-GM2 was not found in three normal human brain samples. The presence of tauro-GM2 in TS brains, but not in normal brains, indicates the possible association of this unusual GM2 derivative with the pathogenesis of TSD. Our findings point to taurine conjugation as a heretofore unelucidated mechanism for TS brain to cope with water-insoluble GM2.

  14. GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.

    PubMed

    Gort, Laura; de Olano, Natalia; Macías-Vidal, Judit; Coll, M A Josep

    2012-09-10

    The GM2 gangliosidoses are autosomal recessive lysosomal storage diseases caused by a deficiency of the β-hexosaminidase A enzyme. This enzyme is composed of two polypeptide chains designated the α- and β- subunits and it interacts with the GM2 activator protein. The HEXA and HEXB genes encode the α-subunit and the β-subunit, respectively. Mutations in these genes are causative of Tay-Sachs disease (HEXA) and Sandhoff disease (HEXB). We analyzed the complete HEXA gene in 34 Spanish patients with Tay-Sachs disease and the HEXB gene in 14 Spanish patients with Sandhoff disease. We identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and we attempted to correlate these mutations with the clinical presentation of the patients. We found a high frequency of c.459+5G>A (IVS4+5G>A) mutation in HEXA affected patients, 22 of 68 alleles, which represent the 32.4%. This is the highest percentage found of this mutation in a population. All patients homozygous for mutation c.459+5G>A presented with the infantile form of the disease and, as previously reported, patients carrying mutation p.R178H in at least one of the alleles presented with a milder form. In HEXB affected patients, the novel deletion c.171delG accounts for 21.4% of the mutant alleles (6/28). All patients with this deletion showed the infantile form of the disease. The Spanish GM2 gangliosidoses affected patients show a great mutational heterogeneity as seen in other inherited lisosomal diseases in this country.

  15. Feasibility studies of time-like proton electromagnetic form factors at overlinePANDA at FAIR

    NASA Astrophysics Data System (ADS)

    Singh, B.; Erni, W.; Krusche, B.; Steinacher, M.; Walford, N.; Liu, B.; Liu, H.; Liu, Z.; Shen, X.; Wang, C.; Zhao, J.; Albrecht, M.; Erlen, T.; Fink, M.; Heinsius, F.; Held, T.; Holtmann, T.; Jasper, S.; Keshk, I.; Koch, H.; Kopf, B.; Kuhlmann, M.; Kümmel, M.; Leiber, S.; Mikirtychyants, M.; Musiol, P.; Mustafa, A.; Pelizäus, M.; Pychy, J.; Richter, M.; Schnier, C.; Schröder, T.; Sowa, C.; Steinke, M.; Triffterer, T.; Wiedner, U.; Ball, M.; Beck, R.; Hammann, C.; Ketzer, B.; Kube, M.; Mahlberg, P.; Rossbach, M.; Schmidt, C.; Schmitz, R.; Thoma, U.; Urban, M.; Walther, D.; Wendel, C.; Wilson, A.; Bianconi, A.; Bragadireanu, M.; Caprini, M.; Pantea, D.; Patel, B.; Czyzycki, W.; Domagala, M.; Filo, G.; Jaworowski, J.; Krawczyk, M.; Lisowski, F.; Lisowski, E.; Michałek, M.; Poznański, P.; Płażek, J.; Korcyl, K.; Kozela, A.; Kulessa, P.; Lebiedowicz, P.; Pysz, K.; Schäfer, W.; Szczurek, A.; Fiutowski, T.; Idzik, M.; Mindur, B.; Przyborowski, D.; Swientek, K.; Biernat, J.; Kamys, B.; Kistryn, S.; Korcyl, G.; Krzemien, W.; Magiera, A.; Moskal, P.; Pyszniak, A.; Rudy, Z.; Salabura, P.; Smyrski, J.; Strzempek, P.; Wronska, A.; Augustin, I.; Böhm, R.; Lehmann, I.; Nicmorus Marinescu, D.; Schmitt, L.; Varentsov, V.; Al-Turany, M.; Belias, A.; Deppe, H.; Dzhygadlo, R.; Ehret, A.; Flemming, H.; Gerhardt, A.; Götzen, K.; Gromliuk, A.; Gruber, L.; Karabowicz, R.; Kliemt, R.; Krebs, M.; Kurilla, U.; Lehmann, D.; Löchner, S.; Lühning, J.; Lynen, U.; Orth, H.; Patsyuk, M.; Peters, K.; Saito, T.; Schepers, G.; Schmidt, C. J.; Schwarz, C.; Schwiening, J.; Täschner, A.; Traxler, M.; Ugur, C.; Voss, B.; Wieczorek, P.; Wilms, A.; Zühlsdorf, M.; Abazov, V.; Alexeev, G.; Arefiev, V. A.; Astakhov, V.; Barabanov, M. Yu.; Batyunya, B. V.; Davydov, Y.; Dodokhov, V. Kh.; Efremov, A.; Fechtchenko, A.; Fedunov, A. G.; Galoyan, A.; Grigoryan, S.; Koshurnikov, E. K.; Lobanov, Y. Yu.; Lobanov, V. I.; Makarov, A. F.; Malinina, L. V.; Malyshev, V.; Olshevskiy, A. G.; Perevalova, E.; Piskun, A. A.; Pocheptsov, T.; Pontecorvo, G.; Rodionov, V.; Rogov, Y.; Salmin, R.; Samartsev, A.; Sapozhnikov, M. G.; Shabratova, G.; Skachkov, N. B.; Skachkova, A. N.; Strokovsky, E. A.; Suleimanov, M.; Teshev, R.; Tokmenin, V.; Uzhinsky, V.; Vodopianov, A.; Zaporozhets, S. A.; Zhuravlev, N. I.; Zorin, A. G.; Branford, D.; Glazier, D.; Watts, D.; Böhm, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Dobbs, S.; Seth, K.; Tomaradze, A.; Xiao, T.; Bettoni, D.; Carassiti, V.; Cotta Ramusino, A.; Dalpiaz, P.; Drago, A.; Fioravanti, E.; Garzia, I.; Savrie, M.; Akishina, V.; Kisel, I.; Kozlov, G.; Pugach, M.; Zyzak, M.; Gianotti, P.; Guaraldo, C.; Lucherini, V.; Bersani, A.; Bracco, G.; Macri, M.; Parodi, R. F.; Biguenko, K.; Brinkmann, K.; Di Pietro, V.; Diehl, S.; Dormenev, V.; Drexler, P.; Düren, M.; Etzelmüller, E.; Galuska, M.; Gutz, E.; Hahn, C.; Hayrapetyan, A.; Kesselkaul, M.; Kühn, W.; Kuske, T.; Lange, J. S.; Liang, Y.; Metag, V.; Nanova, M.; Nazarenko, S.; Novotny, R.; Quagli, T.; Reiter, S.; Rieke, J.; Rosenbaum, C.; Schmidt, M.; Schnell, R.; Stenzel, H.; Thöring, U.; Ullrich, M.; Wagner, M. N.; Wasem, T.; Wohlfahrt, B.; Zaunick, H.; Ireland, D.; Rosner, G.; Seitz, B.; Deepak, P. N.; Kulkarni, A.; Apostolou, A.; Babai, M.; Kavatsyuk, M.; Lemmens, P. J.; Lindemulder, M.; Loehner, H.; Messchendorp, J.; Schakel, P.; Smit, H.; Tiemens, M.; van der Weele, J. C.; Veenstra, R.; Vejdani, S.; Dutta, K.; Kalita, K.; Kumar, A.; Roy, A.; Sohlbach, H.; Bai, M.; Bianchi, L.; Büscher, M.; Cao, L.; Cebulla, A.; Dosdall, R.; Gillitzer, A.; Goldenbaum, F.; Grunwald, D.; Herten, A.; Hu, Q.; Kemmerling, G.; Kleines, H.; Lehrach, A.; Nellen, R.; Ohm, H.; Orfanitski, S.; Prasuhn, D.; Prencipe, E.; Pütz, J.; Ritman, J.; Schadmand, S.; Sefzick, T.; Serdyuk, V.; Sterzenbach, G.; Stockmanns, T.; Wintz, P.; Wüstner, P.; Xu, H.; Zambanini, A.; Li, S.; Li, Z.; Sun, Z.; Xu, H.; Rigato, V.; Isaksson, L.; Achenbach, P.; Corell, O.; Denig, A.; Distler, M.; Hoek, M.; Karavdina, A.; Lauth, W.; Liu, Z.; Merkel, H.; Müller, U.; Pochodzalla, J.; Sanchez, S.; Schlimme, S.; Sfienti, C.; Thiel, M.; Ahmadi, H.; Ahmed, S.; Bleser, S.; Capozza, L.; Cardinali, M.; Dbeyssi, A.; Deiseroth, M.; Feldbauer, F.; Fritsch, M.; Fröhlich, B.; Jasinski, P.; Kang, D.; Khaneft, D.; Klasen, R.; Leithoff, H. H.; Lin, D.; Maas, F.; Maldaner, S.; Martínez, M.; Michel, M.; Mora Espí, M. C.; Morales Morales, C.; Motzko, C.; Nerling, F.; Noll, O.; Pflüger, S.; Pitka, A.; Rodríguez Piñeiro, D.; Sanchez-Lorente, A.; Steinen, M.; Valente, R.; Weber, T.; Zambrana, M.; Zimmermann, I.; Fedorov, A.; Korjik, M.; Missevitch, O.; Boukharov, A.; Malyshev, O.; Marishev, I.; Balanutsa, V.; Balanutsa, P.; Chernetsky, V.; Demekhin, A.; Dolgolenko, A.; Fedorets, P.; Gerasimov, A.; Goryachev, V.; Chandratre, V.; Datar, V.; Dutta, D.; Jha, V.; Kumawat, H.; Mohanty, A. K.; Parmar, A.; Roy, B.; Sonika, G.; Fritzsch, C.; Grieser, S.; Hergemöller, A.; Hetz, B.; Hüsken, N.; Khoukaz, A.; Wessels, J. P.; Khosonthongkee, K.; Kobdaj, C.; Limphirat, A.; Srisawad, P.; Yan, Y.; Barnyakov, M.; Barnyakov, A. Yu.; Beloborodov, K.; Blinov, A. E.; Blinov, V. E.; Bobrovnikov, V. S.; Kononov, S.; Kravchenko, E. A.; Kuyanov, I. A.; Martin, K.; Onuchin, A. P.; Serednyakov, S.; Sokolov, A.; Tikhonov, Y.; Atomssa, E.; Kunne, R.; Marchand, D.; Ramstein, B.; van de Wiele, J.; Wang, Y.; Boca, G.; Costanza, S.; Genova, P.; Montagna, P.; Rotondi, A.; Abramov, V.; Belikov, N.; Bukreeva, S.; Davidenko, A.; Derevschikov, A.; Goncharenko, Y.; Grishin, V.; Kachanov, V.; Kormilitsin, V.; Levin, A.; Melnik, Y.; Minaev, N.; Mochalov, V.; Morozov, D.; Nogach, L.; Poslavskiy, S.; Ryazantsev, A.; Ryzhikov, S.; Semenov, P.; Shein, I.; Uzunian, A.; Vasiliev, A.; Yakutin, A.; Tomasi-Gustafsson, E.; Roy, U.; Yabsley, B.; Belostotski, S.; Gavrilov, G.; Izotov, A.; Manaenkov, S.; Miklukho, O.; Veretennikov, D.; Zhdanov, A.; Makonyi, K.; Preston, M.; Tegner, P.; Wölbing, D.; Bäck, T.; Cederwall, B.; Rai, A. K.; Godre, S.; Calvo, D.; Coli, S.; De Remigis, P.; Filippi, A.; Giraudo, G.; Lusso, S.; Mazza, G.; Mignone, M.; Rivetti, A.; Wheadon, R.; Balestra, F.; Iazzi, F.; Introzzi, R.; Lavagno, A.; Olave, J.; Amoroso, A.; Bussa, M. P.; Busso, L.; De Mori, F.; Destefanis, M.; Fava, L.; Ferrero, L.; Greco, M.; Hu, J.; Lavezzi, L.; Maggiora, M.; Maniscalco, G.; Marcello, S.; Sosio, S.; Spataro, S.; Birsa, R.; Bradamante, F.; Bressan, A.; Martin, A.; Calen, H.; Ikegami Andersson, W.; Johansson, T.; Kupsc, A.; Marciniewski, P.; Papenbrock, M.; Pettersson, J.; Schönning, K.; Wolke, M.; Galnander, B.; Diaz, J.; Pothodi Chackara, V.; Chlopik, A.; Kesik, G.; Melnychuk, D.; Slowinski, B.; Trzcinski, A.; Wojciechowski, M.; Wronka, S.; Zwieglinski, B.; Bühler, P.; Marton, J.; Steinschaden, D.; Suzuki, K.; Widmann, E.; Zmeskal, J.

    2016-10-01

    Simulation results for future measurements of electromagnetic proton form factors at overlinePANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel bar{p}p→ e+e- is studied on the basis of two different but consistent procedures. The suppression of the main background channel, i.e. bar{p}p→ π+π-, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. However, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance.

  16. Form Factors and Wave Functions of Vector Mesons in Holographic QCD

    SciTech Connect

    Hovhannes R. Grigoryan; Anatoly V. Radyushkin

    2007-07-01

    Within the framework of a holographic dual model of QCD, we develop a formalism for calculating form factors of vector mesons. We show that the holographic bound states can be described not only in terms of eigenfunctions of the equation of motion, but also in terms of conjugate wave functions that are close analogues of quantum-mechanical bound state wave functions. We derive a generalized VMD representation for form factors, and find a very specific VMD pattern, in which form factors are essentially given by contributions due to the first two bound states in the Q^2-channel. We calculate electric radius of the \\rho-meson, finding the value < r_\\rho^2>_C = 0.53 fm^2.

  17. High Precision Measurement of the Proton Elastic Form Factor Ratio at Low Q2

    SciTech Connect

    Xiaohui Zhan

    2009-12-01

    A high precision measurement of the proton elastic form factor ratio µpGEp/GMp in the range Q2 = 0.3–0.7 GeV2/c2 was performed using recoil polarimetry in Jefferson Lab Hall A. In this low Q2 range, previous data from LEDEX [5] along with many fits and calculations [2, 3, 4] indicate substantial deviations of the ratio from unity. In this new measurement, with 80% polarized electron beam for 24 days, we are able to achieve <1% statistical uncertainty. Preliminary results are a few percent lower than expected from previous world data and fits, indicating a smaller GEp at this region. Beyond the intrinsic interest in nucleon structure, the improved form factor measurements also have implications for DVCS, determinations of the proton Zemach radius and strangeness form factors through parity violation experiments.

  18. $D$ semileptonic form factors and $|V_{cs(d)}|$ from 2+1 flavor lattice QCD

    SciTech Connect

    Bailey, Jon A.; Bazavov, A.; El-Khadra, A.X.; Gottlieb, Steven; Jain, R.D.; Kronfeld, A.S.; Van de Water, R.S.; Zhou, R.

    2011-11-01

    The measured partial widths of the semileptonic decays D {yields} K{ell}{nu} and D {yields} {pi}{ell}{nu} can be combined with the form factors calculated on the lattice to extract the CKM matrix elements |V{sub cs}| and |V{sub cd}|. The lattice calculations can be checked by comparing the form factor shapes from the lattice and experiment. We have generated a sizable data set by using heavy clover quarks with the Fermilab interpretation for charm and asqtad staggered light quarks on 2+1 flavor MILC ensembles with lattice spacings of approximately 0.12, 0.09, 0.06, and 0.045 fm. Preliminary fits to staggered chiral perturbation theory suggest that we can reduce the uncertainties in the form factors at q{sup 2} = 0 to below 5%.

  19. Electromagnetic form factors of the {Omega}{sup -} in lattice QCD

    SciTech Connect

    Alexandrou, C.; Korzec, T.; Koutsou, G.; Negele, J. W.; Proestos, Y.

    2010-08-01

    We present results on the omega baryon ({Omega}{sup -}) electromagnetic form factors using N{sub f}=2+1 domain-wall fermion configurations for three pion masses in the range of about 350 to 300 MeV. We compare results obtained using domain-wall fermions with those of a mixed-action (hybrid) approach, which combines domain-wall valence quarks on staggered sea quarks, for a pion mass of about 350 MeV. We pay particular attention in the evaluation of the subdominant electric quadrupole form factor to sufficient accuracy to exclude a zero value, by constructing a sequential source that isolates it from the dominant form factors. The {Omega}{sup -} magnetic moment, {mu}{sub {Omega}}{sup -}, and the electric charge and magnetic radius, , are extracted for these pion masses. The electric quadrupole moment is determined for the first time using dynamical quarks.

  20. Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome*

    PubMed Central

    Kumar, Veerendra; Ero, Rya; Ahmed, Tofayel; Goh, Kwok Jian; Zhan, Yin; Bhushan, Shashi; Gao, Yong-Gui

    2016-01-01

    Elongation factor 4 (EF4) is a member of the family of ribosome-dependent translational GTPase factors, along with elongation factor G and BPI-inducible protein A. Although EF4 is highly conserved in bacterial, mitochondrial, and chloroplast genomes, its exact biological function remains controversial. Here we present the cryo-EM reconstitution of the GTP form of EF4 bound to the ribosome with P and E site tRNAs at 3.8-Å resolution. Interestingly, our structure reveals an unrotated ribosome rather than a clockwise-rotated ribosome, as observed in the presence of EF4-GDP and P site tRNA. In addition, we also observed a counterclockwise-rotated form of the above complex at 5.7-Å resolution. Taken together, our results shed light on the interactions formed between EF4, the ribosome, and the P site tRNA and illuminate the GTPase activation mechanism at previously unresolved detail. PMID:27137929

  1. Semiclassical form factor for spectral and matrix element fluctuations of multidimensional chaotic systems.

    PubMed

    Turek, Marko; Spehner, Dominique; Müller, Sebastian; Richter, Klaus

    2005-01-01

    We present a semiclassical calculation of the generalized form factor Kab(tau) which characterizes the fluctuations of matrix elements of the operators a and b in the eigenbasis of the Hamiltonian of a chaotic system. Our approach is based on some recently developed techniques for the spectral form factor of systems with hyperbolic and ergodic underlying classical dynamics and f = 2 degrees of freedom, that allow us to go beyond the diagonal approximation. First we extend these techniques to systems with f > 2. Then we use these results to calculate Kab(tau). We show that the dependence on the rescaled time tau (time in units of the Heisenberg time) is universal for both the spectral and the generalized form factor. Furthermore, we derive a relation between Kab(tau) and the classical time-correlation function of the Weyl symbols of a and b.

  2. Research on design method of the full form ship with minimum thrust deduction factor

    NASA Astrophysics Data System (ADS)

    Zhang, Bao-ji; Miao, Ai-qin; Zhang, Zhu-xin

    2015-04-01

    In the preliminary design stage of the full form ships, in order to obtain a hull form with low resistance and maximum propulsion efficiency, an optimization design program for a full form ship with the minimum thrust deduction factor has been developed, which combined the potential flow theory and boundary layer theory with the optimization technique. In the optimization process, the Sequential Unconstrained Minimization Technique (SUMT) interior point method of Nonlinear Programming (NLP) was proposed with the minimum thrust deduction factor as the objective function. An appropriate displacement is a basic constraint condition, and the boundary layer separation is an additional one. The parameters of the hull form modification function are used as design variables. At last, the numerical optimization example for lines of after-body of 50000 DWT product oil tanker was provided, which indicated that the propulsion efficiency was improved distinctly by this optimal design method.

  3. Master Integrals for Fermionic Contributions to Massless Three-Loop Form Factors

    SciTech Connect

    Heinrich, G.; Huber, T.; Maitre, D.

    2007-11-28

    In this letter we continue the calculation of master integrals for massless three-loop form factors by giving analytical results for those diagrams which are relevant for the fermionic contributions proportional to N{sub F}{sup 2}, N{sub F} {center_dot} N, and N{sub F}/N. Working in dimensional regularization, we express one of the diagrams in a closed form which is exact to all orders in {epsilon}, containing {Lambda}-functions and hypergeometric functions of unit argument. In all other cases we derive multiple Mellin-Barnes representations from which the coefficients of the Laurent expansion in {epsilon} are extracted in an analytical form. To obtain the finite part of the three-loop quark and gluon form factors, all coefficients through transcendentality six in the Riemann {zeta}-function have to be included.

  4. Constraints on the ωπ Form Factor from Analyticity and Unitarity

    NASA Astrophysics Data System (ADS)

    Ananthanarayan, B.; Caprini, Irinel; Kubis, Bastian

    Form factors are important low-energy quantities and an accurate knowledge of these sheds light on the strong interactions. A variety of methods based on general principles have been developed to use information known in different energy regimes to constrain them in regions where experimental information needs to be tested precisely. Here we review our recent work on the electromagnetic ωπ form factor in a model-independent framework known as the method of unitarity bounds, partly motivated by the discre-pancies noted recently between the theoretical calculations of the form factor based on dispersion relations and certain experimental data measured from the decay ω → π0γ*. We have applied a modified dispersive formalism, which uses as input the discontinuity of the ωπ form factor calculated by unitarity below the ωπ threshold and an integral constraint on the square of its modulus above this threshold. The latter constraint was obtained by exploiting unitarity and the positivity of the spectral function of a QCD correlator, computed on the spacelike axis by operator product expansion and perturbative QCD. An alternative constraint is obtained by using data available at higher energies for evaluating an integral of the modulus squared with a suitable weight function. From these conditions we derived upper and lower bounds on the modulus of the ωπ form factor in the region below the ωπ threshold. The results confirm the existence of a disagreement between dispersion theory and experimental data on the ωπ form factor around 0:6 GeV, including those from NA60 published in 2016.

  5. Urban form and psychosocial factors: do they interact for leisure-time walking?

    PubMed

    Beenackers, Mariëlle A; Kamphuis, Carlijn B M; Prins, Richard G; Mackenbach, Johan P; Burdorf, Alex; van Lenthe, Frank J

    2014-02-01

    This cross-sectional study uses an adaptation of a social-ecological model on the hierarchy of walking needs to explore direct associations and interactions of urban-form characteristics and individual psychosocial factors for leisure-time walking. Questionnaire data (n = 736) from adults (25-74 yr) and systematic field observations within 14 neighborhoods in Eindhoven (the Netherlands) were used. Multilevel logistic regression models were used to relate the urban-form characteristics (accessibility, safety, comfort, and pleasurability) and individual psychosocial factors (attitude, self-efficacy, social influence, and intention) to two definitions of leisure-time walking, that is, any leisure-time walking and sufficient leisure-time walking according to the Dutch physical activity norm and to explore their interactions. Leisure-time walking was associated with psychosocial factors but not with characteristics of the urban environment. For sufficient leisure-time walking, interactions between attitude and several urban-form characteristics were found, indicating that positive urban-form characteristics contributed toward leisure-time walking only in residents with a less positive attitude toward physical activity. In contrast, living in a neighborhood that was accessible for walking was stronger associated with leisure-time walking among residents who experienced a positive social influence to engage in physical activity compared with those who reported less social influence. This study showed some evidence for an interaction between the neighborhood environment and the individual psychosocial factors in explaining leisure-time walking. The specific mechanism of interaction may depend on the specific combination of psychosocial factor and environmental factor. The lack of association between urban form and leisure-time walking could be partly due to the little variation in urban-form characteristics between neighborhoods.

  6. An Evaluation of the Factor Structure of the HRM Survey, Forms 9 and 11

    DTIC Science & Technology

    1976-07-01

    Climate, Satisfaction with the Navy, and Equal Opportunity , emerged in both surveys, although in a slightly dif- ferent order. The first three of these...survey (Form 9) and the second, from 477 naval personnel on the shore survey (Form 11). Five factors emerged on both surveys, namely (1) Supervisory...Leadership, (2) Work Group Processes, (3) Command Climate, (4) Satisfaction with the Navy as an Occupation, and (5) Equal Opportunity . In addition

  7. Fourth dimension of the nucleon structure: Spacetime analysis of the timelike electromagnetic proton form factors

    NASA Astrophysics Data System (ADS)

    Bianconi, Andrea; Tomasi-Gustafsson, Egle

    2017-01-01

    As is well known, spacelike proton form factors expressed in the Breit frame may be interpreted as the Fourier transform of static space distributions of electric charge and current. In particular, the electric form factor is simply the Fourier transform of the charge distribution F (q ) =∫ei q ⃗.r ⃗ρ (r ) d3r . We do not have an intuitive interpretation of the same level of simplicity for the proton timelike form factor appearing in the reactions e+e-↔p ¯p . However, one may suggest that, in the center-of-mass frame, where qμxμ=q t , a timelike electric form factor is the Fourier transform F (q ) =∫ei q tR (t ) d t of a function R (t ) expressing how the electric properties of the forming (or annihilating) proton-antiproton pair evolve in time. Here we analyze in depth this idea and show that the functions ρ (r ) and R (t ) can be formally written as the time and space integrals of a unique correlation function depending on both time and space coordinates.

  8. A method for measuring D* electromagnetic form factors in e+ e‑ annihilation

    NASA Astrophysics Data System (ADS)

    Guo, Han; Zhang, Zi-Ping

    2017-09-01

    We describe a method for measuring the electromagnetic form factors of the D* meson at time-like momentum transfer in e+ e‑ annihilation. This is to study the joint angular distribution of the e+e‑→γ*→D*+D*‑, D*+→D0π+, and D*‑→D̅0 π‑ processes. The magnitudes and relative phases of the charge, magnetic and quadrupole form factors can be determined. The method can also be applied to other vector particles. Supported by National Natural Science Foundation of China (11675166)

  9. JLab measurement of the 4He charge form factor at large momentum transfers.

    PubMed

    Camsonne, A; Katramatou, A T; Olson, M; Sparveris, N; Acha, A; Allada, K; Anderson, B D; Arrington, J; Baldwin, A; Chen, J-P; Choi, S; Chudakov, E; Cisbani, E; Craver, B; Decowski, P; Dutta, C; Folts, E; Frullani, S; Garibaldi, F; Gilman, R; Gomez, J; Hahn, B; Hansen, J-O; Higinbotham, D W; Holmstrom, T; Huang, J; Iodice, M; Jiang, X; Kelleher, A; Khrosinkova, E; Kievsky, A; Kuchina, E; Kumbartzki, G; Lee, B; LeRose, J J; Lindgren, R A; Lott, G; Lu, H; Marcucci, L E; Margaziotis, D J; Markowitz, P; Marrone, S; Meekins, D; Meziani, Z-E; Michaels, R; Moffit, B; Norum, B; Petratos, G G; Puckett, A; Qian, X; Rondon, O; Saha, A; Sawatzky, B; Segal, J; Shabestari, M; Shahinyan, A; Solvignon, P; Subedi, R R; Suleiman, R; Sulkosky, V; Urciuoli, G M; Viviani, M; Wang, Y; Wojtsekhowski, B B; Yan, X; Yao, H; Zhang, W-M; Zheng, X; Zhu, L

    2014-04-04

    The charge form factor of 4He has been extracted in the range 29  fm(-2) ≤ Q2 ≤ 77  fm(-2) from elastic electron scattering, detecting 4He recoil nuclei and electrons in coincidence with the high resolution spectrometers of the Hall A Facility of Jefferson Lab. The measurements have uncovered a second diffraction minimum for the form factor, which was predicted in the Q2 range of this experiment. The data are in qualitative agreement with theoretical calculations based on realistic interactions and accurate methods to solve the few-body problem.

  10. JLab Measurement of the He4 Charge Form Factor at Large Momentum Transfers

    NASA Astrophysics Data System (ADS)

    Camsonne, A.; Katramatou, A. T.; Olson, M.; Sparveris, N.; Acha, A.; Allada, K.; Anderson, B. D.; Arrington, J.; Baldwin, A.; Chen, J.-P.; Choi, S.; Chudakov, E.; Cisbani, E.; Craver, B.; Decowski, P.; Dutta, C.; Folts, E.; Frullani, S.; Garibaldi, F.; Gilman, R.; Gomez, J.; Hahn, B.; Hansen, J.-O.; Higinbotham, D. W.; Holmstrom, T.; Huang, J.; Iodice, M.; Jiang, X.; Kelleher, A.; Khrosinkova, E.; Kievsky, A.; Kuchina, E.; Kumbartzki, G.; Lee, B.; LeRose, J. J.; Lindgren, R. A.; Lott, G.; Lu, H.; Marcucci, L. E.; Margaziotis, D. J.; Markowitz, P.; Marrone, S.; Meekins, D.; Meziani, Z.-E.; Michaels, R.; Moffit, B.; Norum, B.; Petratos, G. G.; Puckett, A.; Qian, X.; Rondon, O.; Saha, A.; Sawatzky, B.; Segal, J.; Shabestari, M.; Shahinyan, A.; Solvignon, P.; Subedi, R. R.; Suleiman, R.; Sulkosky, V.; Urciuoli, G. M.; Viviani, M.; Wang, Y.; Wojtsekhowski, B. B.; Yan, X.; Yao, H.; Zhang, W.-M.; Zheng, X.; Zhu, L.; Jefferson Lab Hall A Collaboration

    2014-04-01

    The charge form factor of He4 has been extracted in the range 29 fm-2≤Q2≤77 fm-2 from elastic electron scattering, detecting He4 recoil nuclei and electrons in coincidence with the high resolution spectrometers of the Hall A Facility of Jefferson Lab. The measurements have uncovered a second diffraction minimum for the form factor, which was predicted in the Q2 range of this experiment. The data are in qualitative agreement with theoretical calculations based on realistic interactions and accurate methods to solve the few-body problem.

  11. Light Cone Sum Rules for gamma*N ->Delta Transition Form Factors

    SciTech Connect

    V.M. Braun; A. Lenz; G. Peters; A. Radyushkin

    2006-02-01

    A theoretical framework is suggested for the calculation of {gamma}* N {yields} {Delta} transition form factors using the light-cone sum rule approach. Leading-order sum rules are derived and compared with the existing experimental data. We find that the transition form factors in a several GeV region are dominated by the ''soft'' contributions that can be thought of as overlap integrals of the valence components of the hadron wave functions. The ''minus'' components of the quark fields contribute significantly to the result, which can be reinterpreted as large contributions of the quark orbital angular momentum.

  12. Heavy-quark form factors in the large β _0 limit

    NASA Astrophysics Data System (ADS)

    Grozin, Andrey G.

    2017-07-01

    Heavy-quark form factors are calculated at β _0 α _s ˜ 1 to all orders in α _s at the first order in 1/β _0. Using the inversion relation generalized to vertex functions, we reduce the massive on-shell Feynman integral to the HQET one. This HQET vertex integral can be expressed via a {}_2F_1 function; the nth term of its ɛ expansion is explicitly known. We confirm existing results for n_l^{L-1} α _s^L terms in the form factors (up to L=3), and we present results for higher L.

  13. Computation of form factors in massless QCD with finite master integrals

    NASA Astrophysics Data System (ADS)

    von Manteuffel, Andreas; Panzer, Erik; Schabinger, Robert M.

    2016-06-01

    We present the bare one-, two-, and three-loop form factors in massless quantum chromodynamics as linear combinations of finite master integrals. Using symbolic integration, we compute their ɛ expansions and thereby reproduce all known results with an independent method. Remarkably, in our finite basis, only integrals with a less-than-maximal number of propagators contribute to the cusp anomalous dimensions. We report on indications of this phenomenon at four loops, including the result for a finite, irreducible, twelve-propagator form factor integral. Together with this article, we provide our automated software setup for the computation of finite master integrals.

  14. Generalized heavy-to-light form factors in light-cone sum rules

    NASA Astrophysics Data System (ADS)

    Meißner, Ulf-G.; Wang, Wei

    2014-03-01

    We study the form factors for a heavy meson into the S-wave Kπ/ππ system with an invariant mass below 1 GeV. The mesonic final state interactions are described in terms of the scalar form factors, which are obtained from unitarized chiral perturbation theory. Employing generalized light-cone distribution amplitudes, we compute the heavy-to-light transition using light-cone sum rules. Our approach simultaneously respects constraints from analyticity and unitarity, and also takes advantage of the power expansion in the 1/mb and the strong coupling constant.

  15. On the ππ continuum in the nucleon form factors and the proton radius puzzle

    NASA Astrophysics Data System (ADS)

    Hoferichter, M.; Kubis, B.; Ruiz de Elvira, J.; Hammer, H.-W.; Meißner, U.-G.

    2016-11-01

    We present an improved determination of the ππ continuum contribution to the isovector spectral functions of the nucleon electromagnetic form factors. Our analysis includes the most up-to-date results for the ππ→bar{N} N partial waves extracted from Roy-Steiner equations, consistent input for the pion vector form factor, and a thorough discussion of isospin-violating effects and uncertainty estimates. As an application, we consider the ππ contribution to the isovector electric and magnetic radii by means of sum rules, which, in combination with the accurately known neutron electric radius, are found to slightly prefer a small proton charge radius.

  16. Charge form factors of two-neutron halo nuclei in halo EFT

    NASA Astrophysics Data System (ADS)

    Hagen, P.; Hammer, H.-W.; Platter, L.

    2013-09-01

    We set up a formalism to calculate the charge form factors of two-neutron halo nuclei with S -wave neutron-core interactions in the framework of the halo effective field theory. The method is applied to some known and suspected halo nuclei. In particular, we calculate the form factors and charge radii relative to the core to leading order in the halo EFT and compare to experiments where they are available. Moreover, we investigate the general dependence of the charge radius on the core mass and the one- and two-neutron separation energies.

  17. A form-factor method for determining the structure of distorted stars

    NASA Technical Reports Server (NTRS)

    Wolfe, R. H., Jr.; Kern, J. W.

    1979-01-01

    The equilibrium equations of a uniformly rotating and tidally distorted star are reduced to the same form as for a spherical star except for the inclusion of two form factors. One factor, expressing the buoyancy effects of centrifugal force, is determined directly from the integrated structure variables. The other factor, expressing the deviation from spherical shape, is shown to be relatively insensitive to errors in the assumed shape, so that accurate solutions are obtained in spite of the use of an a priori shape. The method is employed by adding computations for the factors to an existing spherical model program. Upper Main Sequence models determined by this method compare closely with results from the double approximation method even for critical rotation and tidal distortion.

  18. Factor analysis of the Nisonger Child Behavior Rating Form in children with autism spectrum disorders.

    PubMed

    Lecavalier, Luc; Aman, Michael G; Hammer, David; Stoica, Wendy; Mathews, Gregory L

    2004-12-01

    The Nisonger Child Behavior Rating Form (NCBRF) is a behavior rating scale designed for children and adolescents with mental retardation. The purpose of this study was to explore the psychometric properties of the NCBRF in a sample of 330 children and adolescents with autism spectrum disorders (ASDs). Parent and teacher ratings were independently submitted to both exploratory and confirmatory factor analysis. As reported with the original validation study, parent and teacher versions shared similar but somewhat different factor structures. Social competence items showed more similarity with the original solutions than did problem behavior items. Problem behavior items were distributed into a somewhat simpler five-factor solution for both rating forms. Self-injurious and stereotypic items loaded on two distinct subscales for the teacher form, but not on the parent form. Factor loadings and internal consistencies were generally lower than those reported for the original versions but still within the acceptable range. Confirmatory factor analyses indicated good fits for the social competence items and acceptable fits for the problem behavior items. Overall, results supported the construct validity of the NCBRF in children and adolescents with ASDs.

  19. Model-independent constraints on hadronic form factors with above-threshold poles

    NASA Astrophysics Data System (ADS)

    Caprini, Irinel; Grinstein, Benjamín; Lebed, Richard F.

    2017-08-01

    Model-independent constraints on hadronic form factors, in particular those describing exclusive semileptonic decays, can be derived from the knowledge of field correlators calculated in perturbative QCD, using analyticity and unitarity. The location of poles corresponding to below-threshold resonances, i.e., stable states that cannot decay into a pair of hadrons from the crossed channel of the form factor, must be known a priori, and their effect, accounted for through the use of Blaschke factors, is to reduce the strength of the constraints in the semileptonic region. By contrast, above-threshold resonances appear as poles on unphysical Riemann sheets, and their presence does not affect the original model-independent constraints. We discuss the possibility that the above-threshold poles can provide indirect information on the form factors on the first Riemann sheet, either through information from their residues or by constraining the discontinuity function. The bounds on form factors can be improved by imposing, in an exact way, the additional information in the extremal problem. The semileptonic K →π ℓν and D →π ℓν decays are considered as illustrations.

  20. X-ray coherent scattering form factors of tissues, water and plastics using energy dispersion

    NASA Astrophysics Data System (ADS)

    King, B. W.; Landheer, K. A.; Johns, P. C.

    2011-07-01

    A key requirement for the development of the field of medical x-ray scatter imaging is accurate characterization of the differential scattering cross sections of tissues and phantom materials. The coherent x-ray scattering form factors of five tissues (fat, muscle, liver, kidney, and bone) obtained from butcher shops, four plastics (polyethylene, polystyrene, lexan (polycarbonate), nylon), and water have been measured using an energy-dispersive technique. The energy-dispersive technique has several improvements over traditional diffractometer measurements. Most notably, the form factor is measured on an absolute scale with no need for scaling factors. Form factors are reported in terms of the quantity x = λ-1sin (θ/2) over the range 0.363-9.25 nm-1. The coherent form factors of muscle, liver, and kidney resemble those of water, while fat has a narrower peak at lower x, and bone is more structured. The linear attenuation coefficients of the ten materials have also been measured over the range 30-110 keV and parameterized using the dual-material approach with the basis functions being the linear attenuation coefficients of polymethylmethacrylate and aluminum.

  1. Structure and initial validation of a short form of the therapeutic factors inventory.

    PubMed

    Macnair-Semands, Rebecca R; Ogrodniczuk, John S; Joyce, Anthony S

    2010-04-01

    This study examined the factor structure and validity of the Therapeutic Factors Inventory-Short Form (TFI-S), a measure originally developed to assess Yalom's eleven conceptually derived therapeutic factors. Patients in a group-oriented day treatment program (n = 174) completed the TFI-S and other measures to assess concurrent and predictive validity. Four broad therapeutic factors were identified: Instillation of Hope, Secure Emotional Expression, Awareness of Interpersonal Impact, and Social Learning. Alpha coefficients ranged from .71 to .91. Significant correlations between the TFI-S factors and Group Climate Questionnaire subscales provided preliminary evidence for the concurrent validity of the TFI S. Significant relationships were also identified between the TFI-S factors and improvement in symptoms, quality of life, and interpersonal distress at the end of treatment, suggesting that the TFI-S may have predictive validity.

  2. Nucleon form factors with 2+1 flavor dynamical domain-wall fermions

    SciTech Connect

    Takeshi Yamazaki; Aoki, Yasumichi; Blum, Tom; Lin, Huey-Wen; Ohta, Shigemi; Sasaki, Shoichi; Tweedie, Robert; Zanotti, James

    2009-06-01

    We report our numerical lattice QCD calculations of the isovector nucleon form factors for the vector and axialvector currents: the vector, induced tensor, axialvector, and induced pseudoscalar form factors. The calculation is carried out with the gauge configurations generated with N{sub f} = 2+1 dynamical domain wall fermions and Iwasaki gauge actions at {beta} = 2.13, corresponding to a cutoff a{sup -1} = 1.73 GeV, and a spatial volume of (2.7 fm){sup 3}. The up and down quark masses are varied so the pion mass lies between 0.33 and 0.67 GeV while the strange quark mass is about 12% heavier than the physical one. We calculate the form factors in the range of momentum transfers, 0.2 < q{sup 2} < 0.75 GeV{sup 2}. The vector and induced tensor form factors are well described by the conventional dipole forms and result in significant underestimation of the Dirac and Pauli mean-squared radii and the anomalous magnetic moment compared to the respective experimental values. We show that the axial-vector form factor is significantly affected by the finite spatial volume of the lattice. In particular in the axial charge, g{sub A}/g{sub V}, the finite volume effect scales with a single dimensionless quantity, m{sub {pi}}L, the product of the calculated pion mass and the spatial lattice extent. Our results indicate that for this quantity, m{sub {pi}} L > 6 is required to ensure that finite volume effects are below 1%.

  3. Clean measurements of the nucleon axial-vector and free-neutron magnetic form factors

    SciTech Connect

    Deur, A.

    2013-11-07

    We discuss the feasibility of a weak charged current experiment using a low energy electron beam. A first goal is to measure the Q{sup 2} dependence of the axial-vector form factor g{sub a}(Q{sup 2}). It can be measured model-independently and as robustly as for electromagnetic form factors from typical electron scattering experiments, in contrast to the methods used so far to measure g{sub a}(Q{sup 2}). If g{sub a}(Q{sup 2}) follows a dipole form, the axial mass can be extracted with a better accuracy than the world data altogether. The most important detection equipment would be a segmented neutron detector with good momentum and angular resolution that is symmetric about the beam direction, and covers a moderate angular range. A high intensity beam (100 uA) is necessary. Beam polarization is highly desirable as it provides a clean measurement of the backgrounds. Beam energies between 70 and 110 MeV are ideal. This range would provide a Q{sup 2} mapping of g{sub a} between 0.01 form factor G{sub M}{sup n}. The experiment employs the usual techniques of electron-nucleon scattering and presents no special difficulty. Higher energy extensions are possible. They could yield measurements of g{sub a}(Q{sup 2}) up to Q{sup 2}=3 GeV{sup 2} and the possibility to access other form factors, such as the almost unknown pseudoscalar form factor g{sub P}. However, the experiments become much more challenging as soon as beam energies pass the pion production threshold.

  4. Arthroscopic Transtendinous Double-Pulley Remplissage Technique in the Beach-Chair Position for Large Hill-Sachs Lesions

    PubMed Central

    Parnes, Nata; Carey, Paul A.; Schumacher, Christopher; Price, Mark D.

    2015-01-01

    Hill-Sachs lesions are a common finding in patients with glenohumeral instability. There have been numerous methods described for addressing Hill-Sachs deformity. One popular method includes transferring a portion of the infraspinatus muscle into the posterior-superior defect (remplissage) to prevent the lesion from engaging and the resultant instability. We present a method of arthroscopic remplissage whereby the lesion is addressed through transtendinous insertion of arthroscopic anchors. Once 2 anchors have been inserted, 1 limb of each suture is tied to the other anchor, the so-called pulley repair technique. This can be performed either under direct visualization in the subacromial space or blindly while the surgeon is viewing from the articular side. Once both limbs have been tied, the infraspinatus tendon nicely spans the defect, and there has been minimal morbidity to the tendon itself. We have found this method to be useful for addressing a large Hill-Sachs deformity. PMID:26759767

  5. Does Repair of a Hill-Sachs Defect Increase Stability at the Glenohumeral Joint?

    PubMed Central

    Bakshi, Neil K.; Jolly, John T.; Debski, Richard E.; Sekiya, Jon K.

    2016-01-01

    Background: The effect of osteoallograft repair of a Hill-Sachs lesion and the effect of allograft fit on glenohumeral translations in response to applied force are poorly understood. Purpose: To compare the impact of a 25% Hill-Sachs lesion, a perfect osteoallograft repair (PAR) of a 25% Hill-Sachs lesion, and an “imperfect” osteoallograft repair (IAR) of a 25% Hill-Sachs lesion on glenohumeral translations in response to a compressive load and either an anterior or posterior load in 3 clinically relevant arm positions. Study Design: Controlled laboratory study. Methods: A robotic/universal force-moment sensor testing system was used to apply joint compression (22 N) and an anterior or posterior load (44 N) to cadaveric shoulders (n = 9) with the skin and deltoid removed (intact) at 3 glenohumeral joint positions (abduction/external rotation): 0°/0°, 30°/30°, and 60°/60°. The 25% bony defect state, PAR state, and IAR state were created and the loading protocol was performed. Translational motion was measured in each position for each shoulder state. A nonparametric repeated-measures Friedman test with a Wilcoxon signed-rank post hoc test was performed to compare the biomechanical parameters (P < .05). Results: Compared with the defect shoulder, the PAR shoulder had significantly less anterior translation with an anterior load in the 0°/0° (15.3 ± 8.2 vs 16.6 ± 9.0 mm, P = .008) and 30°/30° (13.6 ± 7.1 vs 14.2 ± 7.0 mm, P = .021) positions. Compared with IAR, the PAR shoulder had significantly less anterior translation with an anterior load in the 0°/0° (15.3 ± 8.2 vs 16.6 ± 9.0 mm, P = .008) and 30°/30° (13.6 ± 7.1 vs 14.4 ± 7.1 mm, P = .011) positions, and the defect shoulder had significantly less anterior translation with an anterior load in the 30°/30° (14.2 ± 7.0 vs 14.4 ± 7.0 mm, P = .038) position. Conclusion: PAR resulted in the least translational motion at the glenohumeral joint. The defect shoulder had significantly less

  6. Management of an engaging Hill-Sachs lesion: arthroscopic remplissage with Bankart repair versus Latarjet procedure.

    PubMed

    Cho, Nam Su; Yoo, Jae Hyun; Rhee, Yong Girl

    2016-12-01

    This study compared the clinical outcomes of arthroscopic remplissage with Bankart repair and Latarjet operation in patients with a large engaging Hill-Sachs lesion. Thirty-seven shoulders subjected to arthroscopic remplissage with a Bankart repair (group A) and 35 shoulders subjected to a Latarjet operation (group B), for a large engaging Hill-Sachs lesion without significant glenoid bone loss, were retrospectively evaluated. Each group was followed up for a mean more than 2-year period. At the last follow-up, postoperative pain, shoulder mobility, muscle strength, Rowe score, and UCLA score revealed no significant difference between the two groups. The postoperative mean deficit in external rotation at the side (ERs) was 8° ± 23° in group A (P = 0.044). In group B, the mean deficits in ERs, external rotation at 90° of abduction, and internal rotation to the posterior were 10° ± 20°, 7° ± 16°, and 1.9° ± 4°, respectively (P = 0.004, 0.022, and 0.009, respectively). The recurrence rate was 5.4 % (two shoulders) in group A and 5.7 % (two shoulders) in group B (n.s.). The overall complication rate was significantly higher in group B (14.3 %) than in group A (0 %) (P = 0.017). For recurrent anterior shoulder instability with a large engaging Hill-Sachs lesion, both arthroscopic remplissage with Bankart repair and the Latarjet procedure were safe and reliable techniques with a low recurrence rate. However, the Latarjet group had a significantly higher postoperative complication rate than the remplissage group. Case-control study, Level III.

  7. Arthroscopic remplissage with Bankart repair for the treatment of glenohumeral instability with Hill-Sachs defects.

    PubMed

    Park, Min Jung; Tjoumakaris, Fotios P; Garcia, Grant; Patel, Amit; Kelly, John D

    2011-09-01

    To determine whether arthroscopic remplissage with Bankart repair is an effective treatment strategy for patients with Bankart lesions and large Hill-Sachs defects. Between 2006 and 2008, 20 patients underwent arthroscopic Bankart repair with remplissage for the treatment of recurrent anterior glenohumeral instability and large Hill-Sachs defects. Preoperative imaging in all patients identified avulsion of the anterior inferior glenohumeral ligament with an associated Hill-Sachs defect that involved greater than 25% of the humeral head. Patients were followed up postoperatively with the Western Ontario Shoulder Instability score, the American Shoulder and Elbow Surgeons score, and the Penn Shoulder Score. Recurrent subluxation or dislocation was documented. There were 15 male patients and 5 female patients. The mean age of the patients was 27.3 years. The mean length of follow-up in this series was 29.2 months (range, 24.3 to 37.7 months). At final follow-up, 3 patients reported recurrence of instability, which spontaneously reduced in all cases. The mean American Shoulder and Elbow Surgeons score was 92.5 (pain, 47.3; function, 45.3). The mean Penn score was 90 of 100 (pain, 27.3 of 30; satisfaction, 8.5 of 10; function, 54.3 of 60). The mean total Western Ontario Shoulder Instability score was 72.74% (mean physical symptom score, 77.10%; mean sports and recreation score, 70.25%; mean lifestyle score, 75%; mean emotions score, 58.50%). Using an all-arthroscopic remplissage technique with Bankart repair, we were able to restore function, diminish pain, and yield satisfaction in 85% of the patients in this study. Our results compare favorably with historic controls with similar pathology at early- to intermediate-term follow-up in terms of recurrence. Level IV, therapeutic case series. Copyright © 2011 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  8. Form factor dispersion at La M5,4 edges and average density of resonant atoms.

    PubMed

    Smadici, S; Lee, J C T; Logvenov, G; Bozovic, I; Abbamonte, P

    2014-01-15

    Resonant soft x-ray scattering on complex oxide superlattices shows very large variations in the superlattice reflection position and intensity near La M5,4 edges. Resonant dispersion of the La x-ray form factor describes the observations well. We determine the average density of resonant La atoms and the thickness of superlattice layers.

  9. New Precision Limit on the Strange Vector Form Factors of the Proton

    SciTech Connect

    Ahmed, Z.; Allada, K.; Aniol, K. A.; Armstrong, D. S.; Arrington, J.; Baturin, P.; Bellini, V.; Benesch, J.; Beminiwattha, R.; Benmokhtar, F.; Canan, M.; Camsonne, A.; Cates, G. D.; Chen, J. -P.; Chudakov, E.; Cisbani, E.; Dalton, M. M.; de Jager, C. W.; De Leo, R.; Deconinck, W.; Decowski, P.; Deng, X.; Deur, A.; Dutta, C.; Franklin, G. B.; Friend, M.; Frullani, S.; Garibaldi, F.; Giusa, A.; Glamazdin, A.; Golge, S.; Grimm, K.; Hansen, O.; Higinbotham, D. W.; Holmes, R.; Holmstrom, T.; Huang, J.; Huang, M.; Hyde, C. E.; Jen, C. M.; Jin, G.; Jones, D.; Kang, H.; King, P.; Kowalski, S.; Kumar, K. S.; Lee, J. H.; LeRose, J. J.; Liyanage, N.; Long, E.; McNulty, D.; Margaziotis, D.; Meddi, F.; Meekins, D. G.; Mercado, L.; Meziani, Z. -E.; Michaels, R.; Muñoz-Camacho, C.; Mihovilovic, M.; Muangma, N.; Myers, K. E.; Nanda, S.; Narayan, A.; Nelyubin, V.; Nuruzzaman, None; Oh, Y.; Pan, K.; Parno, D.; Paschke, K. D.; Phillips, S. K.; Qian, X.; Qiang, Y.; Quinn, B.; Rakhman, A.; Reimer, P. E.; Rider, K.; Riordan, S.; Roche, J.; Rubin, J.; Russo, G.; Saenboonruang, K.; Saha, A.; Sawatzky, B.; Silwal, R.; Sirca, S.; Souder, P. A.; Sperduto, M.; Subedi, R.; Suleiman, R.; Sulkosky, V.; Sutera, C. M.; Tobias, W. A.; Urciuoli, G. M.; Waidyawansa, B.; Wang, D.; Wexler, J.; Wilson, R.; Wojtsekhowski, B.; Zhan, X.; Yan, X.; Yao, H.; Ye, L.; Zhao, B.; Zheng, X.

    2012-03-01

    The parity-violating cross-section asymmetry in the elastic scattering of polarized electrons from unpolarized protons has been measured at a four-momentum transfer squared Q2 = 0.624 GeV2 and beam energy Eb = 3.48 GeV to be APV = -23.80 ± 0.78 (stat) ± 0.36 (syst) parts per million. This result is consistent with zero contribution of strange quarks to the combination of electric and magnetic form factors GEs + 0.517 GMs = 0.003 ± 0.010 (stat) ± 0.004 (syst) ± 0.009 (ff), where the third error is due to the limits of precision on the electromagnetic form factors and radiative corrections. With this measurement, the world data on strange contributions to nucleon form factors are seen to be consistent with zero and not more than a few percent of the proton form factors.

  10. New Precision Limit on the Strange Vector Form Factors of the Proton

    DOE PAGES

    Ahmed, Z.; Allada, K.; Aniol, K. A.; ...

    2012-03-01

    The parity-violating cross-section asymmetry in the elastic scattering of polarized electrons from unpolarized protons has been measured at a four-momentum transfer squared Q2 = 0.624 GeV2 and beam energy Eb = 3.48 GeV to be APV = -23.80 ± 0.78 (stat) ± 0.36 (syst) parts per million. This result is consistent with zero contribution of strange quarks to the combination of electric and magnetic form factors GEs + 0.517 GMs = 0.003 ± 0.010 (stat) ± 0.004 (syst) ± 0.009 (ff), where the third error is due to the limits of precision on the electromagnetic form factors and radiative corrections.more » With this measurement, the world data on strange contributions to nucleon form factors are seen to be consistent with zero and not more than a few percent of the proton form factors.« less

  11. The electromagnetic Sigma-to-Lambda hyperon transition form factors at low energies

    DOE PAGES

    Granados, Carlos; Leupold, Stefan; Perotti, Elisabetta

    2017-06-09

    Using dispersion theory the low-energy electromagnetic form factors for the transition of a Sigma to a Lambda hyperon are related to the pion vector form factor. The additionally required input, i.e. the two-pion-Sigma-Lambda amplitudes are determined from relativistic next-to-leading-order (NLO) baryon chiral perturbation theory including the baryons from the octet and optionally from the decuplet. Pion rescattering is again taken into account by dispersion theory. It turns out that the inclusion of decuplet baryons is not an option but a necessity to obtain reasonable results. The electric transition form factor remains very small in the whole low-energy region. The magneticmore » transition form factor depends strongly on one not very well determined low-energy constant of the NLO Lagrangian. Furthermore, one obtains reasonable predictive power if this low-energy constant is determined from a measurement of the magnetic transition radius. Such a measurement can be performed at the future Facility for Antiproton and Ion Research (FAIR).« less

  12. A small-form-factor piezoelectric vibration energy harvester using a resonant frequency-down conversion

    SciTech Connect

    Sun, Kyung Ho; Kim, Young-Cheol; Kim, Jae Eun

    2014-10-15

    While environmental vibrations are usually in the range of a few hundred Hertz, small-form-factor piezoelectric vibration energy harvesters will have higher resonant frequencies due to the structural size effect. To address this issue, we propose a resonant frequency-down conversion based on the theory of dynamic vibration absorber for the design of a small-form-factor piezoelectric vibration energy harvester. The proposed energy harvester consists of two frequency-tuned elastic components for lowering the first resonant frequency of an integrated system but is so configured that an energy harvesting beam component is inverted with respect to the other supporting beam component for a small form factor. Furthermore, in order to change the unwanted modal characteristic of small separation of resonant frequencies, as is the case with an inverted configuration, a proof mass on the supporting beam component is slightly shifted toward a second proof mass on the tip of the energy harvesting beam component. The proposed small-form-factor design capability was experimentally verified using a fabricated prototype with an occupation volume of 20 × 39 × 6.9 mm{sup 3}, which was designed for a target frequency of as low as 100 Hz.

  13. Studies of Nucleon Form Factors with 12 GeV CEBAF and SuperBigBite

    SciTech Connect

    Hansen, Jens-Ole

    2012-04-01

    The elastic electromagnetic form factors are among the most fundamental quantities that describe the ground-state structure of the proton and neutron. Precision data of the form factors over a wide kinematical range provide a powerful test of current theories of hadron structure. A number of experiments aiming to measure the electric and magnetic elastic form factors of the neutron, G{sub E}{sup n} and G{sub M}{sup n}, and proton, G{sub E}{sup p}, at very high momentum transfer, up to the range of Q{sup 2} = 10-14 (GeV/c){sup 2}, are planned to be carried out with the future 11 GeV electron beam of the upgraded CEBAF at Jefferson Lab. These experiments will determine the nucleon form factors with unprecedented precision to Q{sup 2}-values up to three times higher than those of existing data. We review the approved proposals and the conceptual design of a new spectrometer, SuperBigBite, that will be used in these and other future experiments at Jefferson Lab.

  14. Measurement of the ratio of the proton's electric to magnetic form factors by recoil polarization

    SciTech Connect

    Mark K. Jones; Hall A Collaboration

    1999-03-01

    The longitudinal and transverse polarizations of the outgoing proton were measured for the reaction {sup 1}H(e,e' p) at four-momentum transfer squared of 0.5 to 3.5 GeV{sup 2}. The ratio of the electric to magnetic form factors of the proton is proportional to the ratio of the transverse to longitudinal polarizations.

  15. Proton Form Factor Puzzle and the CEBAF Large Acceptance Spectrometer (CLAS) Two-Photon Exchange Experiment

    SciTech Connect

    Rimal, Dipak

    2014-05-01

    The electromagnetic form factors are the most fundamental observables that encode information about the internal structure of the nucleon. This dissertation explored dependence of R on kinematic variables such as squared four-momentum transfer (Q2) and the virtual photon polarization parameter (ε).

  16. Relativistic corrections to the form factors of Bc into S -wave charmonium

    NASA Astrophysics Data System (ADS)

    Zhu, Ruilin; Ma, Yan; Han, Xin-Ling; Xiao, Zhen-Jun

    2017-05-01

    We investigate the form factors of Bc meson into S -wave charmonium within the nonrelativistic QCD effective theory and obtain the next-to-leading order relativistic corrections to the form factors, where both the Bc meson and the charmonium are treated as the nonrelativistic bound states. Treating the charm quark as a light quark in the limit mc/mb→0 , some form factors are identical at the maximum recoil point, which are consistent with the predictions in the heavy-quark effective theory and the large-energy effective theory. Considering that the branching ratios of Bc+→J /ψ Ds+ and Bc+→J /ψ Ds*+ have been measured by the LHCb and ATLAS Collaborations recently, we employ the form factors of Bc meson into S -wave charmonium at the next-to-leading order accuracy to these two decay channels and obtain more precise predictions of their decay rates. Numerical results indicate that the factorizable diagrams dominate the contribution in these two channels, while the color-suppressed and the annihilation diagrams contribute less than 10 percent. Our results are consistent with the LHCb and ATLAS data.

  17. The charge form factor of pseudoscalar mesons in a relativistic constituent quark model

    SciTech Connect

    Cardarelli, F.; Pace, E.; Grach, I.L.

    1994-04-01

    The charge form factor of pseudoscalar mesons has been investigated in the light-cone formalism, up to Q{sup 2} relevant to CEBAF energies. The consequences of adopting the meson wave functions generated through the Godfrey-Isgur q{bar q} potential, which reproduces the mass spectra, are discussed.

  18. Nuclear longitudinal form factors for axially deformed charge distributions expanded by nonorthogonal basis functions

    NASA Astrophysics Data System (ADS)

    Liu, Jian; Zhang, Jinjuan; Xu, Chang; Ren, Zhongzhou

    2017-05-01

    In this paper, the nuclear longitudinal form factors are systematically studied from the intrinsic charge multipoles. For axially deformed nuclei, two different types of density profiles are used to describe their charge distributions. For the same charge distributions expanded with different basis functions, the corresponding longitudinal form factors are derived and compared with each other. Results show the multipoles Cλ of longitudinal form factors are independent of the basis functions of charge distributions. Further numerical calculations of longitudinal form factors of 12C indicates that the C 0 multipole reflects the contributions of spherical components of all nonorthogonal basis functions. For deformed nuclei, their charge RMS radii can also be determined accurately by the C 0 measurement. The studies in this paper examine the model-independent properties of electron scattering, which are useful for interpreting electron scattering experiments on exotic deformed nuclei. Supported by National Natural Science Foundation of China (11505292, 11175085, 11575082, 11235001, 11275138, and 11447226), by Shandong Provincial Natural Science Foundation, China (BS2014SF007), Fundamental Research Funds for Central Universities (15CX02072A).

  19. A small-form-factor piezoelectric vibration energy harvester using a resonant frequency-down conversion

    NASA Astrophysics Data System (ADS)

    Sun, Kyung Ho; Kim, Young-Cheol; Kim, Jae Eun

    2014-10-01

    While environmental vibrations are usually in the range of a few hundred Hertz, small-form-factor piezoelectric vibration energy harvesters will have higher resonant frequencies due to the structural size effect. To address this issue, we propose a resonant frequency-down conversion based on the theory of dynamic vibration absorber for the design of a small-form-factor piezoelectric vibration energy harvester. The proposed energy harvester consists of two frequency-tuned elastic components for lowering the first resonant frequency of an integrated system but is so configured that an energy harvesting beam component is inverted with respect to the other supporting beam component for a small form factor. Furthermore, in order to change the unwanted modal characteristic of small separation of resonant frequencies, as is the case with an inverted configuration, a proof mass on the supporting beam component is slightly shifted toward a second proof mass on the tip of the energy harvesting beam component. The proposed small-form-factor design capability was experimentally verified using a fabricated prototype with an occupation volume of 20 × 39 × 6.9 mm3, which was designed for a target frequency of as low as 100 Hz.

  20. Factor Structure and Short Form of the Miville-Guzman Universality-Diversity Scale.

    ERIC Educational Resources Information Center

    Fuertes, Jairo N.; Miville, Marie L.; Mohr, Jonathan J.; Sedlacek, William E.; Gretchen, Denise

    2000-01-01

    Examines the factor structure of the Miville-Guzman Universality-Diversity Scale (M-GUDS) and presents a short form of the scale (M-GUDS-S). Findings suggest that the M-GUDS-S measures Universal-Diverse Orientation as a multidimensional construct with three distinct domains: behavioral, emotional, and cognitive. (Contains 21 references and 3…

  1. Measuring the axial form factor of {sup 3}He using weak capture of polarized electrons

    SciTech Connect

    Dutta, D.

    2013-11-07

    A low energy, high intensity polarized electron beam could enable the extraction of the A=3 weak axial form factors F{sub A} using the reaction →e+{sup 3}He→{sup 3}H+ν. These form factors have never been measured before. We discuss the feasibility of such an experiment using a small toroidal magnet and a radial low energy recoil detector to tag the recoil tritons. A moderately high intensity polarized electron beam (>500 μA) with beam energies between 50 - 150 MeV is necessary for the cross section measurement and to provides a free clean measurement of the background. Moreover, in addition to the cross section, by measuring the electron spin and recoil triton correlation coefficient it may be possible to search for second class currents and to extract the ratio of the axial to the vector form factor of the nucleon. Such novel electron scattering based measurements would have a completely different set of systematic uncertainties compared to polarized neutron beta decay, neutrino scattering and muon capture experiments which are typically used to extract the weak form-factors.

  2. Elastic Form Factors of 3,4He up to Large Q2

    SciTech Connect

    Kees De Jager

    2007-09-10

    Elastic electron scattering off $^3$He and $^4$He has recently been studied at forward and backward scattering angles in Hall A at JLab. The results will provide accurate data on the elastic form factors, charge and magnetic for $^3$He and charge only for $^4$He, up to squared momentum transfer $Q^2$-values of 3.2 GeV$^2$.

  3. Lattice QCD results for the B --> D(*) l nu form factors: F(1) and G(1)

    SciTech Connect

    Van de Water, R.S.; /Fermilab

    2007-01-01

    I review the current status of lattice QCD calculations of the B {yields} D and B {yields} D* form factors and discuss prospects for their improvement. Successful calculations within the quenched approximation demonstrate the power of lattice methods for calculating F(1) and G(1), and the unquenched calculations in progress should soon allow for a 2-3% exclusive determination of |Vcb|.

  4. The electromagnetic Sigma-to-Lambda hyperon transition form factors at low energies

    NASA Astrophysics Data System (ADS)

    Granados, Carlos; Leupold, Stefan; Perotti, Elisabetta

    2017-06-01

    Using dispersion theory the low-energy electromagnetic form factors for the transition of a Sigma to a Lambda hyperon are related to the pion vector form factor. The additionally required input, i.e. the two-pion-Sigma-Lambda amplitudes are determined from relativistic next-to-leading-order (NLO) baryon chiral perturbation theory including the baryons from the octet and optionally from the decuplet. Pion rescattering is again taken into account by dispersion theory. It turns out that the inclusion of decuplet baryons is not an option but a necessity to obtain reasonable results. The electric transition form factor remains very small in the whole low-energy region. The magnetic transition form factor depends strongly on one not very well determined low-energy constant of the NLO Lagrangian. One obtains reasonable predictive power if this low-energy constant is determined from a measurement of the magnetic transition radius. Such a measurement can be performed at the future Facility for Antiproton and Ion Research (FAIR).

  5. Strangeness Vector and Axial-Vector Form Factors of the Nucleon

    NASA Astrophysics Data System (ADS)

    Pate, Stephen; Trujillo, Dennis

    2014-03-01

    A revised global fit of electroweak ep and vp elastic scattering data has been performed, with the goal of determining the strange quark contribution to the vector and axial-vector form factors of the nucleon in the momentum-transfer range 0 < Q2 < 1 GeV2. The two vector (electric and magnetic) form factors GsE(Q2) and GsM(Q2) are strongly constrained by ep elastic scattering data, while the major source of information on the axial-vector form factor GsA(Q2) is vp scattering data. Combining the two kinds of data into a single global fit makes possible additional precision in the determination of these form factors, and provides a unique way to determine the strange quark contribution to the nucleon spin, ΔS , independently of leptonic deep-inelastic scattering. The fit makes use of data from the BNL-E734, SAMPLE, HAPPEx, G0, and PVA4 experiments; we will also compare the result of the fit with recent data from MiniBooNE, and anticipate how this fit can be improved when new data from MicroBooNE become available.

  6. Strangeness Vector and Axial-Vector Form Factors of the Nucleon

    NASA Astrophysics Data System (ADS)

    Trujillo, Dennis; Pate, Stephen

    2013-04-01

    A revised global fit of electroweak ep and νp elastic scattering data has been performed, with the goal of determining the strange quark contribution to the vector and axial-vector form factors of the nucleon in the momentum-transfer range 0form factors GE^s(Q^2) and GM^s(Q^2) are strongly constrained by ep elastic scattering data, while the major source of information on the axial-vector form factor GA^s(Q^2) is νp scattering data. Combining the two kinds of data into a single global fit makes possible additional precision in the determination of these form factors. The fit makes use of data from the BNL-E734, SAMPLE, HAPPEx, G0, and PVA4 experiments; we will also compare the result of the fit with recent data from MiniBooNE, and anticipate how this fit can be improved when new data from MicroBooNE become available.

  7. Electromagnetic Transition Form Factor of the η meson with WASA-at-COSY

    NASA Astrophysics Data System (ADS)

    Goswami, A.

    2016-11-01

    In this work we present a study of the Dalitz decay η → γe+e-. The aim of this work is to measure the transition form factor of the η meson. The transition form factor of the η meson describes the electromagnetic structure of the meson. The study of the Dalitz decay helps to calculate the transition form factor of the η meson. When a particle is point-like it's decay rate can be calculated within QED. However, the complex structure of the meson modifies its decay rate. The transition form factor is determined by comparing the lepton-antilepton invariant mass distribution with QED. For this study data on proton-proton reaction at a beam energy of 1.4 GeV has been collected with WASA-at-COSY detector at Forschungszentrum Juelich, Germany. In the higher invariant mass region recent theoretical calculations slightly deviate from the fit to the data. We expect better results in the higher invariant mass region than previous measurements. The preliminary results of the analysis will be presented.

  8. The Short Form of the Five-Factor Narcissism Inventory: Psychometric Equivalence of the Turkish Version

    ERIC Educational Resources Information Center

    Eksi, Füsun

    2016-01-01

    This study intends to examine the psychometric properties of the Turkish version of the short form of the Five-Factor Narcissism Inventory (FFNI-SF). The study group consists of a total of 526 university students (54% were female) whose ages range from 18 to 32. In the translational equivalence study made over a two-week interval, the FFNI-SF…

  9. Biomechanical Evaluation of Glenoid Version and Dislocation Direction on the Influence of Anterior Shoulder Instability and Development of Hill-Sachs Lesions.

    PubMed

    Eichinger, Josef K; Massimini, Daniel F; Kim, Jungryul; Higgins, Laurence D

    2016-11-01

    Abnormal glenoid version is a risk factor for shoulder instability. However, the degree to which the variance in version (both anteversion and retroversion) affects one's predisposition for instability is not well understood. To determine the influence of glenoid version on anterior shoulder joint stability and to determine if the direction of the humeral head dislocation is a stimulus for the development of Hill-Sachs lesions. Controlled laboratory study. Ten human cadaveric shoulders (mean age, 59.4 ± 4.3 years) were tested using a custom shoulder dislocation device placed in a position of apprehension (90° of abduction with 90° of external rotation). Glenoid version was adjusted in 5° increments for a total of 6 version angles tested: +10°, +5°, 0°, -5°, -10°, and -15° (anteversion angles are positive, and retroversion angles are negative). Two humeral dislocation directions were tested. The first direction was true anterior through the anterior-posterior glenoid axis. The second dislocation direction was 35° inferior from the anterior-posterior glenoid axis based on the deforming force role of the pectoralis major. The force and energy to dislocate were recorded. Changes in glenoid version manifested a linear effect on the dislocation force. The energy to dislocate increased as a second-order polynomial as a function of increasing glenoid retroversion. Glenoid version of +10° anteversion and -15° retroversion was highly unstable, resulting in spontaneous dislocation in one-quarter (10/40) and one-half (25/40) of the specimens anteriorly and posteriorly, respectively, in the absence of an applied dislocation force. The greater tuberosity was observed to engage with the anterior glenoid rim, consistent with Hill-Sachs lesions, 40% more frequently when the dislocation direction was true anterior compared with 35° inferior from the anterior-posterior glenoid axis. The engagement of the greater tuberosity caused an increase in the energy required to

  10. Bound state structure and electromagnetic form factor beyond the ladder approximation

    NASA Astrophysics Data System (ADS)

    Gigante, V.; Nogueira, J. H. Alvarenga; Ydrefors, E.; Gutierrez, C.; Karmanov, V. A.; Frederico, T.

    2017-03-01

    We investigate the response of the bound state structure of a two-boson system, within a Yukawa model with a scalar boson exchange, to the inclusion of the cross-ladder contribution to the ladder kernel of the Bethe-Salpeter equation. The equation is solved by means of the Nakanishi integral representation and light-front projection. The valence light-front wave function and electromagnetic form factor, considering both ladder and ladder plus cross-ladder kernels, are studied in detail. Their asymptotic forms are found to be quite independent of the inclusion of the cross-ladder kernel, for a given binding energy. The asymptotic decrease of form factor agrees with the counting rules. This analysis can be generalized to fermionic systems, with a wide application in the study of the meson structure.

  11. Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.

    PubMed

    Optican, Lance M; Rucker, Janet C; Keller, Edward L; Leigh, R John

    2008-01-01

    In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs).

  12. Canonical realization of (2 +1 )-dimensional Bondi-Metzner-Sachs symmetry

    NASA Astrophysics Data System (ADS)

    Batlle, Carles; Campello, Víctor; Gomis, Joaquim

    2017-07-01

    We construct canonical realizations of the (2+1)-dimensional Bondi-Metzner-Sachs (bm s 3 ) algebra as symmetry algebras of a free Klein-Gordon (KG) field in 2 +1 dimensions for both massive and massless cases. We consider two types of realizations, one on shell, written in terms of the Fourier modes of the scalar field, and the other off shell, with nonlocal transformations written in terms of the KG field and its momenta. These realizations contain both supertranslations and superrotations, for which we construct the corresponding Noether charges.

  13. Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease

    PubMed Central

    Optican, Lance M.; Rucker, Janet C.; Keller, Edward L.; Leigh, R. John

    2009-01-01

    In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs). PMID:18718355

  14. Model-independent dark energy differentiation with the integrated Sachs-Wolfe effect.

    PubMed

    Corasaniti, P S; Bassett, B A; Ungarelli, C; Copeland, E J

    2003-03-07

    We study the integrated Sachs-Wolfe effect using a model-independent parametrization of the dark energy equation of state, w(z). Cosmic variance severely restricts the class of models distinguishable from one based on cold dark matter and a cosmological constant unless w(z) currently satisfies w(o)(Q)>-0.8, or exhibits a rapid, late-time, transition at redshifts z<3. Because of the degeneracy with other cosmological parameters, models with a slowly varying w(z) cannot be differentiated from each other or from a cosmological constant. This may place a fundamental limit on our understanding of the origin of the currently observed acceleration.

  15. Detectability of a phantom-like braneworld model with the integrated Sachs-Wolfe effect

    SciTech Connect

    Giannantonio, Tommaso; Song, Yong-Seon; Koyama, Kazuya

    2008-08-15

    We study a braneworld model in which a phantom-like behavior occurs with only cold dark matter and a cosmological constant, due to a large distance modification of gravity. With the addition of curvature, the geometrical tests are not strict enough to rule out models in which gravity is modified significantly on large scales. We show that this degeneracy in the parameter space is broken by the structure formation tests, such as the integrated Sachs-Wolfe effect, which can probe general relativity on large scales.

  16. Remplissage versus latarjet for engaging Hill-Sachs defects without substantial glenoid bone loss: a biomechanical comparison.

    PubMed

    Degen, Ryan M; Giles, Joshua W; Johnson, James A; Athwal, George S

    2014-08-01

    Recurrent shoulder instability is commonly associated with Hill-Sachs defects. These defects may engage the glenoid rim, contributing to glenohumeral dislocation. Two treatment options to manage engaging Hill-Sachs defects are the remplissage procedure, which fills the defect with soft tissue, and the Latarjet procedure, which increases glenoid arc length. Little evidence exists to support one over the other. We performed a biomechanical comparison of the remplissage procedure to the traditional Latarjet coracoid transfer for management of engaging Hill-Sachs defects in terms of joint stiffness (resistance to anterior translation), ROM, and frequency of dislocation. Eight cadaveric specimens were tested on a shoulder instability simulator. Testing was performed with a 25% Hill-Sachs defect with an intact glenoid and after remplissage and Latarjet procedures. Joint stiffness, internal-external rotation ROM, and frequency of dislocation were assessed. Additionally, horizontal extension ROM was measured in composite glenohumeral abduction. After remplissage, stiffness increased in adduction with neutral rotation (12.7 ± 3.7 N/mm) relative to the Hill-Sachs defect state (8.7 ± 3.3 N/mm; p = 0.016). The Latarjet procedure did not affect joint stiffness (p = 1.0). Internal-external rotation ROM was reduced in abduction after the Latarjet procedure (49° ± 14°) compared with the Hill-Sachs defect state (69° ± 17°) (p = 0.009). Horizontal extension was reduced after remplissage (16° ± 12°) relative to the Hill-Sachs defect state (34° ± 8°) (p = 0.038). With the numbers available, there was no difference between the procedures in terms of the frequency of dislocation after reconstruction: 84% of specimens (27 of 32 testing scenarios) stabilized after remplissage, while 94% of specimens (30 of 32 testing scenarios) stabilized after the Latarjet procedure. Both procedures proved effective in reducing the frequency of dislocation in a 25% Hill-Sachs defect model

  17. Assessment of coincidence and defect sizes in Bankart and Hill–Sachs lesions after anterior shoulder dislocation: a radiological study

    PubMed Central

    Von Harten, R; Weber, C; Andruszkow, H; Pfeifer, R; Dienstknecht, T; Pape, H C

    2014-01-01

    Objective: Bankart and Hill–Sachs lesions are often associated with anterior shoulder dislocation. The MRI technique is sensitive in diagnosing both injuries. The aim of this study was to investigate Bankart and Hill–Sachs lesions with MRI to determine the correlation in occurrence and defect sizes of these lesions. Methods: Between 2006 and 2013, 446 patients were diagnosed with an anterior shoulder dislocation and 105 of these patients were eligible for inclusion in the study. All patients were examined using MRI. Bankart lesions were classified as cartilaginous or bony lesions. Hill–Sachs lesions were graded I–III using a modified Calandra classification. Results: The co-occurrence of injuries was high [odds ratio (OR) = 11.47; 95% confidence interval (CI) = 3.60–36.52; p < 0.001]. Patients older than 29 years more often presented with a bilateral injury (OR = 16.29; 95% CI = 2.71–97.73; p = 0.002). A correlation between a Bankart lesion and the grade of a Hill–Sachs lesion was found (ρ = 0.34; 95% CI = 0.16–0.49; p < 0.001). Bankart lesions co-occurred more often with large Hill–Sachs lesions (OR = 1.24; 95% CI = 1.02–1.52; p = 0.033). Conclusion: If either lesion is diagnosed, the patient is 11 times more likely to have suffered the associated injury. The size of a Hill–Sachs lesion determines the co-occurrence of cartilaginous or bony Bankart lesions. Age plays a role in determining the type of Bankart lesion as well as the co-occurrence of Bankart and Hill–Sachs lesions. Advances in knowledge: This study is the first to demonstrate the use of high-quality MRI in a reasonably large sample of patients, a positive correlation of Bankart and Hill–Sachs lesions in anterior shoulder dislocations and an association between the defect sizes. PMID:24452107

  18. Induced drag ideal efficiency factor of arbitrary lateral-vertical wing forms

    NASA Technical Reports Server (NTRS)

    Deyoung, J.

    1980-01-01

    A relatively simple equation is presented for estimating the induced drag ideal efficiency factor e for arbitrary cross sectional wing forms. This equation is based on eight basic but varied wing configurations which have exact solutions. The e function which relates the basic wings is developed statistically and is a continuous function of configuration geometry. The basic wing configurations include boxwings shaped as a rectangle, ellipse, and diamond; the V-wing; end-plate wing; 90 degree cruciform; circle dumbbell; and biplane. Example applications of the e equations are made to many wing forms such as wings with struts which form partial span rectangle dumbbell wings; bowtie, cruciform, winglet, and fan wings; and multiwings. Derivations are presented in the appendices of exact closed form solutions found of e for the V-wing and 90 degree cruciform wing and for an asymptotic solution for multiwings.

  19. Rpf Proteins Are the Factors of Reactivation of the Dormant Forms of Actinobacteria.

    PubMed

    Nikitushkin, V D; Demina, G R; Kaprelyants, A S

    2016-12-01

    As the response to unfavorable growth conditions, nonsporulating mycobacteria transform into the dormant state with the concomitant formation of the specialized dormant forms characterized by low metabolic activity and resistance to antibiotics. Such dormant cells can be reactivated under the influence of several factors including proteins of Rpf (Resuscitation promoting factor) family, which possess peptidoglycan hydrolase activity and were considered to belong to the group of the autocrine growth factors of the bacteria. Remarkable interest toward Rpf family is determined by its participation in resuscitation of the dormant forms of Mycobacterium tuberculosis, what in turn is the key element in resuscitation of the latent tuberculosis - an infectious disease that affects one third of the World's population. Experiments with Rpf mutant forms and with strains deleted in these proteins revealed a relationship between the enzymatic activity of this protein and its ability to resuscitate mycobacteria both in vitro and in vivo. This review discusses possible mechanisms of Rpf action including those related to possible participation of the products of mycobacterial Rpf-mediated cell wall hydrolysis (muropeptides) as signaling molecules. The unique ability of Rpf proteins to resuscitate the dormant forms of mycobacteria and to stimulate their proliferation would allow these proteins to occupy their niche in medicine - in diagnostics and in creation of antituberculosis subunit vaccines.

  20. Up, down, and strange nucleon axial form factors from lattice QCD

    DOE PAGES

    Green, Jeremy; Hasan, Nesreen; Meinel, Stefan; ...

    2017-06-14

    Here, we report a calculation of the nucleon axial form factorsmore » $$G_A^q(Q^2)$$ and $$G_P^q(Q^2)$$ for all three light quark flavors $$q\\in\\{u,d,s\\}$$ in the range $$0\\leq Q^2\\lesssim 1.2\\text{ GeV}^2$$ using lattice QCD. Our work was done using a single ensemble with pion mass 317 MeV and made use of the hierarchical probing technique to efficiently evaluate the required disconnected loops. We perform nonperturbative renormalization of the axial current, including a nonperturbative treatment of the mixing between light and strange currents due to the singlet-nonsinglet difference caused by the axial anomaly. The form factor shapes are fit using the model-independent $z$ expansion. From $$G_A^q(Q^2)$$, we determine the quark contributions to the nucleon spin and axial radii. By extrapolating the isovector $$G_P^{u-d}(Q^2)$$, we obtain the induced pseudoscalar coupling relevant for ordinary muon capture and the pion-nucleon coupling constant. We also found that the disconnected contributions to $$G_P$$ form factors are large, and give an interpretation based on the dominant influence of the pseudoscalar poles in these form factors.« less

  1. Form factors of descendant operators: reduction to perturbed M (2 , 2 s + 1) models

    NASA Astrophysics Data System (ADS)

    Lashkevich, Michael; Pugai, Yaroslav

    2015-04-01

    In the framework of the algebraic approach to form factors in two-dimensional integrable models of quantum field theory we consider the reduction of the sine-Gordon model to the Φ13-perturbation of minimal conformal models of the M (2 , 2 s + 1) series. We find in an algebraic form the condition of compatibility of local operators with the reduction. We propose a construction that make it possible to obtain reduction compatible local operators in terms of screening currents. As an application we obtain exact multiparticle form factors for the compatible with the reduction conserved currents T ±2 k , Θ±(2 k-2), which correspond to the spin ±(2 k - 1) integrals of motion, for any positive integer k. Furthermore, we obtain all form factors of the operators T 2 k T -2 l , which generalize the famous operator. The construction is analytic in the s parameter and, therefore, makes sense in the sine-Gordon theory.

  2. Sudakov Resummation for Subleading SCET Currents and Heavy-to-Light Form Factors

    SciTech Connect

    Hill, R J

    2004-04-25

    The hard-scattering contributions to heavy-to-light form factors at large recoil are studied systematically in soft-collinear effective theory (SCET). Large logarithms arising from multiple energy scales are resummed by matching QCD onto SCET in two stages via an intermediate effective theory. Anomalous dimensions in the intermediate theory are computed, and their form is shown to be constrained by conformal symmetry. Renormalization-group evolution equations are solved to give a complete leading-order analysis of the hard-scattering contributions, in which all single and double logarithms are resummed. In two cases, spin-symmetry relations for the soft-overlap contributions to form factors are shown not to be broken at any order in perturbation theory by hard-scattering corrections. One-loop matching calculations in the two effective theories are performed in sample cases, for which the relative importance of renormalization-group evolution and matching corrections is investigated. The asymptotic behavior of Sudakov logarithms appearing in the coefficient functions of the soft-overlap and hard-scattering contributions to form factors is analyzed.

  3. The structure of light-front wavefunctions and constraints on hadronic form factors

    SciTech Connect

    S. J. Brodsky; J. R. Hiller; D. S. Hwang; V. A. Karmanov

    2003-11-17

    We study the analytic structure of light-front wave functions (LFWFs) and its consequences for hadron form factors using an explicitly Lorentz-invariant formulation of the front form. The normal to the light front is specified by a general null vector {omega}{sup {mu}}. The LFWFs with definite total angular momentum are eigenstates of a kinematic angular momentum operator and satisfy all Lorentz symmetries. They are analytic functions of the invariant mass squared of the constituents M{sub 0}{sup 2} = ({Sigma} k{sup {mu}}){sup 2} and the light-cone momentum fractions x{sub i} = k{sub i} {center_dot} {omega}/p {center_dot} {omega} multiplied by invariants constructed from the spin matrices, polarization vectors, and {omega}{sup {mu}}. These properties are illustrated using known nonperturbative eigensolutions of the Wick-Cutkosky model. We analyze the LFWFs introduced by Chung and Coester to describe static and low momentum properties of the nucleons. They correspond to the spin-locking of a quark with the spin of its parent nucleon, tog ether with a positive-energy projection constraint. These extra constraints lead to anomalous dependence of form factors on Q rather than Q{sup 2}. In contrast, the dependence of LFWFs on M{sub 0}{sup 2} implies that hadron form factors are analytic functions of Q{sup 2} in agreement with dispersion theory and perturbative QCD. We show that a model incorporating the leading-twist perturbative QCD prediction is consistent with recent data for the ratio of proton Pauli and Dirac form factors.

  4. The Role of Nerve Growth Factor (NGF) and Its Precursor Forms in Oral Wound Healing.

    PubMed

    Schenck, Karl; Schreurs, Olav; Hayashi, Katsuhiko; Helgeland, Kristen

    2017-02-11

    Nerve growth factor (NGF) and its different precursor forms are secreted into human saliva by salivary glands and are also produced by an array of cells in the tissues of the oral cavity. The major forms of NGF in human saliva are forms of pro-nerve growth factor (pro-NGF) and not mature NGF. The NGF receptors tropomyosin-related kinase A (TrkA) and p75 neurotrophin receptor (p75(NTR)) are widely expressed on cells in the soft tissues of the human oral cavity, including keratinocytes, endothelial cells, fibroblasts and leukocytes, and in ductal and acinar cells of all types of salivary glands. In vitro models show that NGF can contribute at most stages in the oral wound healing process: restitution, cell survival, apoptosis, cellular proliferation, inflammation, angiogenesis and tissue remodeling. NGF may therefore take part in the effective wound healing in the oral cavity that occurs with little scarring. As pro-NGF forms appear to be the major form of NGF in human saliva, efforts should be made to study its function, specifically in the process of wound healing. In addition, animal and clinical studies should be initiated to examine if topical application of pro-NGF or NGF can be a therapy for chronic oral ulcerations and wounds.

  5. Forming factors of gas hydrate chimney in the Ulleung Basin, East Sea

    NASA Astrophysics Data System (ADS)

    Kang, Dong-Hyo; Chun, Jong-Hwa; Koo, Nam-Hyng; Kim, Won-Sik; Lee, Ho-Young; Lee, Joo-Yong

    2016-04-01

    Seismic chimneys ranging in width from 200 m to 1,000 m are observed in the seismic sections obtained in the Ulleung Basin, East Sea. In consequence of Ulleung Basin Gas Hydrate Expedition 1 and 2, concentrations of gas hydrates were identified. Especially, 6 chimney sites were drilled and the occurrence of gas hydrate was identified at all wells. Through the interpreting seismic section, three factors affect the formation of gas hydrate chimney; mass transport deposit, fault, igneous intrusion. These three factors result in three case of forming gas hydrate chimney. Firstly, gas hydrate chimney appears predominantly in the fault zone. Deep-rooted fault reach to mass transport deposit and gas hydrate chimney which is mostly rooted in mass transport deposit is formed. Secondly, Gas hydrate chimney appears linked to igneous intrusion. Igneous intrusion result in forming fault in overlying strata. Similar to first case, this fault traverses mass transport deposit and gas hydrate chimney rooted in mass transport deposit is created. Thirdly, gas hydrate chimney is formed at thick mass transport deposit without fault. In this case, chimney is not reach to seabed in contrast with first and second case. The thickness of mass transport deposit is 0.2 second in two-way travel times. Overburden load cause to pressure at the upper part of mass transport deposit. This leads to fracture in overlying sediments and form gas hydrate chimney.

  6. The Role of Nerve Growth Factor (NGF) and Its Precursor Forms in Oral Wound Healing

    PubMed Central

    Schenck, Karl; Schreurs, Olav; Hayashi, Katsuhiko; Helgeland, Kristen

    2017-01-01

    Nerve growth factor (NGF) and its different precursor forms are secreted into human saliva by salivary glands and are also produced by an array of cells in the tissues of the oral cavity. The major forms of NGF in human saliva are forms of pro-nerve growth factor (pro-NGF) and not mature NGF. The NGF receptors tropomyosin-related kinase A (TrkA) and p75 neurotrophin receptor (p75NTR) are widely expressed on cells in the soft tissues of the human oral cavity, including keratinocytes, endothelial cells, fibroblasts and leukocytes, and in ductal and acinar cells of all types of salivary glands. In vitro models show that NGF can contribute at most stages in the oral wound healing process: restitution, cell survival, apoptosis, cellular proliferation, inflammation, angiogenesis and tissue remodeling. NGF may therefore take part in the effective wound healing in the oral cavity that occurs with little scarring. As pro-NGF forms appear to be the major form of NGF in human saliva, efforts should be made to study its function, specifically in the process of wound healing. In addition, animal and clinical studies should be initiated to examine if topical application of pro-NGF or NGF can be a therapy for chronic oral ulcerations and wounds. PMID:28208669

  7. Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease.

    PubMed

    Cohen-Tannoudji, M; Marchand, P; Akli, S; Sheardown, S A; Puech, J P; Kress, C; Gressens, P; Nassogne, M C; Beccari, T; Muggleton-Harris, A L

    1995-12-01

    Tay-Sachs disease is an autosomal recessive lysosomal storage disease caused by beta-hexosaminidase A deficiency and leads to death in early childhood. The disease results from mutations in the HEXA gene, which codes for the alpha chain of beta-hexosaminidase. The castastrophic neurodegenerative progression of the disease is thought to be a consequence of massive neuronal accumulation of GM2 ganglioside and related glycolipids in the brain and nervous system of the patients. Fuller understanding of the pathogenesis and the development of therapeutic procedures have both suffered from the lack of an animal model. We have used gene targeting in embryonic stem (ES) cells to disrupt the mouse Hexa gene. Mice homozygous for the disrupted allele mimic several biochemical and histological features of human Tay-Sachs disease. Hexa-/- mice displayed a total deficiency of beta-hexosaminidase A activity, and membranous cytoplasmic inclusions typical of GM2 gangliosidoses were found in the cytoplasm of their neurons. However, while the number of storage neurons increased with age, it remained low compared with that found in human, and no apparent motor or behavioral disorders could be observed. This suggests that the presence of beta-hexosaminidase A is not an absolute requirement of ganglioside degradation in mice. These mice should help us to understand several aspects of the disease as well as the physiological functions of hexosaminidase in mice. They should also provide a valuable animal model in which to test new forms of therapy, and in particular gene delivery into the central nervous system.

  8. Development of a Short Form of the Five-Factor Narcissism Inventory: the FFNI-SF.

    PubMed

    Sherman, Emily D; Miller, Joshua D; Few, Lauren R; Campbell, W Keith; Widiger, Thomas A; Crego, Cristina; Lynam, Donald R

    2015-09-01

    The Five-Factor Narcissism Inventory (FFNI; Glover, Miller, Lynam, Crego, & Widiger, 2012) is a 148-item self-report inventory of 15 traits designed to assess the basic elements of narcissism from the perspective of a 5-factor model. The FFNI assesses both vulnerable (i.e., cynicism/distrust, need for admiration, reactive anger, and shame) and grandiose (i.e., acclaim seeking, arrogance, authoritativeness, entitlement, exhibitionism, exploitativeness, grandiose fantasies, indifference, lack of empathy, manipulativeness, and thrill seeking) variants of narcissism. The present study reports the development of a short-form version of the FFNI in 4 diverse samples (i.e., 2 undergraduate samples, a sample recruited from MTurk, and a clinical community sample) using item response theory. The validity of the resultant 60-item short form was compared against the validity of the full scale in the 4 samples at both the subscale level and the level of the grandiose and vulnerable composites. Results indicated that the 15 subscales remain relatively reliable, possess a factor structure identical to the structure of the long-form scales, and manifest correlational profiles highly similar to those of the long-form scales in relation to a variety of criterion measures, including basic personality dimensions, other measures of grandiose and vulnerable narcissism, and indicators of externalizing and internalizing psychopathology. Grandiose and vulnerable composites also behave almost identically across the short- and long-form versions. It is concluded that the FFNI-Short Form (FFNI-SF) offers a well-articulated assessment of the basic traits comprising grandiose and vulnerable narcissism, particularly when assessment time is limited.

  9. Measurement of the form factor ratios in semileptonic decays of charm mesons

    SciTech Connect

    Zaliznyak, Renata

    1998-05-01

    I have measured the form factor ratios r2 = A2 (0)/A1 (0) and rV = V (0)/A1 (0) in the semileptonic charm meson decay D+ → $\\bar{K}$*0 e+ve from data collected by the Fermilab E791 collaboration. Form factors are introduced in the calculation of the hadronic current in semileptonic decays of strange, charm, or bottom mesons, such as D+ → $\\bar{K}$*0 e+ ve . Semileptonic decays provide insight into quark coupling to the W boson since the leptonic and hadronic amplitudes in the Feynman diagram for the decay are completely separate. There are no strong interactions between the final state leptons and quarks. A number of theoretical models predict the values of the form factors for D+ → $\\bar{K}$*0 e+ ve , though there is a large range of predictions. E791 is a hadroproduction experiment that recorded over 20 billion interactions with a 500 GeV π- beam incident on five thin targets during the 1991-92 Fermilab fixed-target run. Approximately 3000 D+ → $\\bar{K}$*0 e+ ve decays are fully reconstructed. In order to extract the form factor ratios from the data, I implement a multidimensional unbinned maximum likelihood fit with a large sample of simulated (Monte Carlo) D+ → $\\bar{K}$*0 e+ve events. The large E791 data sample provides the most precise measurement of the form factor ratios to date. The measured values for the form factor ratios are r2 = 0.71 ± 0.08 ± 0.09 and rV = 1.84 ± 0.11 ±} 0.08. These results are in good agreement with some Lattice Gauge calculations. However the agreement with quark model predictions is not as good.

  10. The three loop slope of the Dirac form factor and the S Lamb shift in hydrogen

    SciTech Connect

    Melnikov, K.

    1999-12-08

    The last unknown contribution to hydrogen energy levels at order malpha{sup 7}, due to the slope of the Dirac form factor at three loops, is evaluated in a closed analytical form. The resulting shift of the hydrogen nS energy level is found to be 3.016/n{sup 3} kHz. Using the QED calculations of the 1S Lamb shift, the authors extract a precise value of the proton charge radius r{sub p} = 0.883{+-}0.014 fm.

  11. Geodesic completeness and the lack of strong singularities in effective loop quantum Kantowski-Sachs spacetime

    NASA Astrophysics Data System (ADS)

    Saini, Sahil; Singh, Parampreet

    2016-12-01

    Resolution of singularities in the Kantowski-Sachs model due to non-perturbative quantum gravity effects is investigated. Using the effective spacetime description for the improved dynamics version of loop quantum Kantowski-Sachs spacetimes, we show that even though expansion and shear scalars are universally bounded, there can exist events where curvature invariants can diverge. However, such events can occur only for very exotic equations of state when pressure or derivatives of energy density with respect to triads become infinite at a finite energy density. In all other cases curvature invariants are proved to remain finite for any evolution in finite proper time. We find the novel result that all strong singularities are resolved for arbitrary matter. Weak singularities pertaining to above potential curvature divergence events can exist. The effective spacetime is found to be geodesically complete for particle and null geodesics in finite time evolution. Our results add to a growing evidence for generic resolution of strong singularities using effective dynamics in loop quantum cosmology by generalizing earlier results on isotropic and Bianchi-I spacetimes.

  12. AAV gene therapy in a sheep model of Tay-Sachs disease.

    PubMed

    Gray-Edwards, Heather; Randle, Ashley N; Maitland, Stacy; Benatti, Hector; Hubbard, Spencer; Canning, Peter; Vogel, Matthew; Brunson, Brandon; Hwang, Misako; Ellis, Lauren; Bradbury, Allison M; Gentry, Atoska; Taylor, Amanda; Wooldridge, Anne; Wilhite, Dewey; Winter, Randoplh; Whitlock, Brain; Johnson, Jacob A; Holland, Merrilee; Salibi, Nouha; Beyers, Ronald; Sartin, James; Denney, Thomas; Cox, Nancy R; Sena-Esteves, Miguel; Martin, Douglas R

    2017-09-19

    Tay-Sachs disease (TSD) is a fatal neurodegenerative disorder caused by a deficiency of the enzyme hexosaminidase A (HexA). Tay-Sachs disease also occurs in sheep, the only experimental model of TSD that has clinical signs of disease. The natural history of sheep TSD was characterized using serial neurological evaluations, 7 tesla MRI, echocardiograms, electrodiagnostics and cerebrospinal fluid (CSF) biomarkers. Intracranial gene therapy was also tested using AAVrh8 monocistronic vectors encoding the α subunit of Hex (TSD α) or a mixture of two vectors encoding both the α and β subunits separately (TSD α+β) injected at high (1.3 x1013vg) or low (4.2x1012vg) dose. Delay of symptom onset and/or reduction of acquired symptoms were noted in all AAV treated sheep. Post-mortem evaluation showed superior HexA and vector genome distribution in the brain of TSD α+β sheep compared to TSD α sheep, but spinal cord distribution was low in all groups. Isozyme analysis showed superior HexA formation after treatment with both vectors (TSD α+β) and ganglioside clearance was most widespread in the TSD α+β high dose sheep. Microglial activation and proliferation in TSD sheep - most prominent in the cerebrum - were attenuated after gene therapy. This report demonstrates therapeutic efficacy for TSD in the sheep brain, which is in the same order of magnitude as a child's brain.

  13. Integrated Sachs-Wolfe effect in a quintessence cosmological model: Including anisotropic stress of dark energy

    SciTech Connect

    Wang, Y. T.; Xu, L. X.; Gui, Y. X.

    2010-10-15

    In this paper, we investigate the integrated Sachs-Wolfe effect in the quintessence cold dark matter model with constant equation of state and constant speed of sound in dark energy rest frame, including dark energy perturbation and its anisotropic stress. Comparing with the {Lambda}CDM model, we find that the integrated Sachs-Wolfe (ISW)-power spectrums are affected by different background evolutions and dark energy perturbation. As we change the speed of sound from 1 to 0 in the quintessence cold dark matter model with given state parameters, it is found that the inclusion of dark energy anisotropic stress makes the variation of magnitude of the ISW source uncertain due to the anticorrelation between the speed of sound and the ratio of dark energy density perturbation contrast to dark matter density perturbation contrast in the ISW-source term. Thus, the magnitude of the ISW-source term is governed by the competition between the alterant multiple of (1+3/2xc-circumflex{sub s}{sup 2}) and that of {delta}{sub de}/{delta}{sub m} with the variation of c-circumflex{sub s}{sup 2}.

  14. Prospects for using coherent elastic neutrino-nucleus scattering to measure the nuclear neutron form factor

    NASA Astrophysics Data System (ADS)

    Patton, Kelly; McLaughlin, Gail; Scholberg, Kate; Engel, Jon; Schunck, Nicolas

    2017-01-01

    Coherent elastic neutrino-nucleus scattering is a potential probe of nuclear neutron form factors. We show that the neutron root-mean-square (RMS) radius can be measured with tonne-scale detectors of argon, germanium, or xenon. In addition, the fourth moment of the neutron distribution can be studied experimentally using this method. The impacts of both detector size and detector shape uncertainty on such a measurement were considered. The important limiting factor was found to be the detector shape uncertainty. In order to measure the neutron RMS radius to 5%, comparable to current experimental uncertainties, the detector shape uncertainty needs to be known to 1% or better.

  15. Factor structure and validity of the parenting stress index-short form.

    PubMed

    Haskett, Mary E; Ahern, Lisa S; Ward, Caryn S; Allaire, Jason C

    2006-06-01

    The psychometric properties of the Parenting Stress Index-Short Form (PSI-SF) were examined in a sample of 185 mothers and fathers. Factor analysis revealed 2 reasonably distinct factors involving parental distress and dysfunctional parent-child interactions. Both scales were internally consistent, and these scales were correlated with measures of parent psychopathology, parental perceptions of child adjustment, and observed parent and child behavior. PSI-SF scores were related to parent reports of child behavior 1 year later, and the Childrearing Stress subscale was a significant predictor of a parental history of abuse.

  16. High-throughput spectrometer designs in a compact form-factor: principles and applications

    NASA Astrophysics Data System (ADS)

    Norton, S. M.

    2013-05-01

    Many compact, portable Raman spectrometers have entered the market in the past few years with applications in narcotics and hazardous material identification, as well as verification applications in pharmaceuticals and security screening. Often, the required compact form-factor has forced designers to sacrifice throughput and sensitivity for portability and low-cost. We will show that a volume phase holographic (VPH)-based spectrometer design can achieve superior throughput and thus sensitivity over conventional Czerny-Turner reflective designs. We will look in depth at the factors influencing throughput and sensitivity and illustrate specific VPH-based spectrometer examples that highlight these design principles.

  17. Covariant spectator theory for the electromagnetic three-nucleon form factors: Complete impulse approximation

    SciTech Connect

    Pinto, Sergio Alexandre; Stadler, Alfred; Gross, Franz

    2009-05-15

    We present the first calculations of the electromagnetic form factors of {sup 3}He and {sup 3}H within the framework of the Covariant Spectator Theory (CST). This first exploratory study concentrates on the sensitivity of the form factors to the strength of the scalar meson-nucleon off-shell coupling, known from previous studies to have a strong influence on the three-body binding energy. Results presented here were obtained using the complete impulse approximation (CIA), which includes contributions of relativistic origin that appear as two-body corrections in a nonrelativistic framework, such as 'Z-graphs', but omits other two and three-body currents. We compare our results to nonrelativistic calculations augmented by relativistic corrections of O(v/c){sup 2}.

  18. Covariant spectator theory for the electromagnetic three-nucleon form factors: Complete impulse approximation

    SciTech Connect

    Pinto, Sérgio Alexandre; Stadler, Alfred; Gross, Franz

    2009-05-01

    We present the first calculations of the electromagnetic form factors of 3He and 3H within the framework of the Covariant Spectator Theory (CST). This first exploratory study concentrates on the sensitivity of the form factors to the strength of the scalar meson-nucleon off-shell coupling, known from previous studies to have a strong influence on the three-body binding energy. Results presented here were obtained using the complete impulse approximation (CIA), which includes contributions of relativistic origin that appear as two-body corrections in a non-relativistic framework, such as "Z-graphs," but omits other two and three-body currents. Finally, we compare our results to non-relativistic calculations augmented by relativistic corrections of O(v/c)2.

  19. Covariant spectator theory for the electromagnetic three-nucleon form factors: Complete impulse approximation

    SciTech Connect

    Alexandre Pinto, SÂ ergio; Stadler, Alfred; Gross, Franz

    2009-01-01

    We present the first calculations of the electromagnetic form factors of 3He and 3H within the framework of the Covariant Spectator Theory (CST). This first exploratory study concentrates on the sensitivity of the form factors to the strength of the scalar meson-nucleon off-shell coupling, known from previous studies to have a strong influence on the three-body binding energy. Results presented here were obtained using the complete impulse approximation (CIA), which includes contributions of relativistic origin that appear as two-body corrections in a non-relativistic framework, such as ?Z-graphs?, but omits other two and three-body currents. We compare our results to non-relativistic calculations augmented by relativistic corrections of O(v/c)2.

  20. The electromagnetic form factors of the Λ in the timelike region

    NASA Astrophysics Data System (ADS)

    Haidenbauer, J.; Meißner, U.-G.

    2016-10-01

    The reaction e+e- → Λ bar Λ is investigated for energies close to the threshold. Specific emphasis is put on the role played by the interaction in the final Λ bar Λ system which is taken into account rigorously. For that interaction a variety of Λ bar Λ potential models is employed that have been constructed for the analysis of the reaction p bar p → Λ bar Λ in the past. The enhancement of the effective form factor for energies close to the Λ bar Λ threshold, seen in pertinent experiments, is reproduced. Predictions for the Λ electromagnetic form factors GM and GE in the timelike region and for spin-dependent observables such as spin-correlation parameters are presented.

  1. η -γ and η'-γ transition form factors in a nonlocal NJL model

    NASA Astrophysics Data System (ADS)

    Gómez Dumm, D.; Noguera, S.; Scoccola, N. N.

    2017-03-01

    We study the η and η' distribution amplitudes (DAs) in the context of a nonlocal SU(3 ) L⊗SU(3 ) R chiral quark model. The corresponding Lagrangian allows us to reproduce the phenomenological values of pseudoscalar meson masses and decay constants, as well as the momentum dependence of the quark propagator arising from lattice calculations. It is found that the obtained DAs have two symmetric maxima, which arise from new contributions generated by the nonlocal character of the interactions. These DAs are then applied to the calculation of the η -γ and η'-γ transition form factors. Implications of our results regarding higher twist corrections and/or contributions to the transition form factors originated by gluon-gluon components in the η and η' mesons are discussed.

  2. A note on NMHV form factors from the Graßmannian and the twistor string

    NASA Astrophysics Data System (ADS)

    Meidinger, David; Nandan, Dhritiman; Penante, Brenda; Wen, Congkao

    2017-09-01

    In this note we investigate Graßmannian formulas for form factors of the chiral part of the stress-tensor multiplet in N=4 superconformal Yang-Mills theory. We present an all- n contour for the G(3 , n + 2) Graßmannian integral of NMHV form factors derived from on-shell diagrams and the BCFW recursion relation. In addition, we study other G(3 , n + 2) formulas obtained from the connected prescription introduced recently. We find a recursive expression for all n and study its properties. For n ≥ 6, our formula has the same recursive structure as its amplitude counterpart, making its soft behaviour manifest. Finally, we explore the connection between the two Graßmannian formulations, using the global residue theorem, and find that it is much more intricate compared to scattering amplitudes.

  3. B→πll Form Factors for New Physics Searches from Lattice QCD.

    PubMed

    Bailey, Jon A; Bazavov, A; Bernard, C; Bouchard, C M; DeTar, C; Du, Daping; El-Khadra, A X; Freeland, E D; Gámiz, E; Gottlieb, Steven; Heller, U M; Kronfeld, A S; Laiho, J; Levkova, L; Liu, Yuzhi; Lunghi, E; Mackenzie, P B; Meurice, Y; Neil, E; Qiu, Si-Wei; Simone, J N; Sugar, R; Toussaint, D; Van de Water, R S; Zhou, Ran

    2015-10-09

    The rare decay B→πℓ^{+}ℓ^{-} arises from b→d flavor-changing neutral currents and could be sensitive to physics beyond the standard model. Here, we present the first ab initio QCD calculation of the B→π tensor form factor f_{T}. Together with the vector and scalar form factors f_{+} and f_{0} from our companion work [J. A. Bailey et al., Phys. Rev. D 92, 014024 (2015)], these parametrize the hadronic contribution to B→π semileptonic decays in any extension of the standard model. We obtain the total branching ratio BR(B^{+}→π^{+}μ^{+}μ^{-})=20.4(2.1)×10^{-9} in the standard model, which is the most precise theoretical determination to date, and agrees with the recent measurement from the LHCb experiment [R. Aaij et al., J. High Energy Phys. 12 (2012) 125].

  4. The time-like electromagnetic form factors of proton and charged kaon at high energies

    NASA Astrophysics Data System (ADS)

    Anulli, Fabio

    2016-05-01

    The Initial State Radiation method in the BABAR experiment has been used to measure the time-like electromagnetic form factors at the momentum transfer from 9 to 42 (GeV/c)2 for proton and from 7 to 56 (GeV/c)2 for charged kaon. The obtained data show the tendency to approach the QCD asymptotic prediction for kaons and space-like form factor values for proton. The BABAR data have been used together with data from other experiments, to perform a model-independent determination of the relative phases between the single-photon and the three-gluon amplitudes in ψ → KK ¯ decays. The values of the branching fractions measured in the reaction e+e- → K+ K- are shifted due to interference of resonant and nonresonant amplitudes. We have determined the absolute values of the shifts to be 5% for J/ψ and 15% for ψ(2S) decays.

  5. The [Formula: see text] transition form factor from space- and time-like experimental data.

    PubMed

    Escribano, R; Masjuan, P; Sanchez-Puertas, P

    The [Formula: see text] transition form factor is analyzed for the first time in both space- and time-like regions at low and intermediate energies in a model-independent approach through the use of rational approximants. The [Formula: see text] experimental data provided by the A2 Collaboration in the very low-energy region of the dielectron invariant mass distribution allows for the extraction of the most precise up-to-date slope and curvature parameters of the form factors as well as their values at zero and infinity. The impact of these new results on the mixing parameters of the [Formula: see text]-[Formula: see text] system, together with the role played by renormalization dependent effects, and on the determination of the [Formula: see text] couplings from [Formula: see text] and [Formula: see text] radiative decays is also discussed.

  6. CFD-based method of determining form factor k for different ship types and different drafts

    NASA Astrophysics Data System (ADS)

    Wang, Jinbao; Yu, Hai; Zhang, Yuefeng; Xiong, Xiaoqing

    2016-09-01

    The value of form factor k at different drafts is important in predicting full-scale total resistance and speed for different types of ships. In the ITTC community, most organizations predict form factor k using a low-speed model test. However, this method is problematic for ships with bulbous bows and transom. In this article, a Computational Fluid Dynamics (CFD)-based method is introduced to obtain k for different type of ships at different drafts, and a comparison is made between the CFD method and the model test. The results show that the CFD method produces reasonable k values. A grid generating method and turbulence model are briefly discussed in the context of obtaining a consistent k using CFD.

  7. Shock Response of the Clamped Disk in Small Form Factor Hard Disk Drive

    NASA Astrophysics Data System (ADS)

    Gu, Bin; Shu, Dongwei; Shi, Baojun; Lu, Guoxing

    As small form factor (one-inch and smaller) hard disk drives are widely used in portable consumer appliances and gadgets, their mechanical robustness is of greater concern. In the previous work, it is found that when the disk is more tightly clamped, it helps to decrease the shock response of the disk and then avoid the head slap. In this paper, the real boundary condition of the disk for a small form factor hard disk drive from Seagate is investigated numerically. The disk is clamped between the clamp and the hub. The shock response of the disk under a half-sine acceleration pulse is simulated by using the finite element method. In the finite element model, both contact between disk and clamp and contact between disk and hub are considered. According to the simulation results, how to decrease the shock response of the disk is suggested.

  8. SCET Sum Rules for B to P and B to V Transition Form Factors

    SciTech Connect

    De Fazio, Fulvia; Feldmann, Thorsten; Hurth, Tobias; /CERN /SLAC

    2007-12-18

    We investigate sum rules for heavy-to-light transition form factors at large recoil derived from correlation functions with interpolating currents for light pseudoscalar or vector fields in soft-collinear effective theory (SCET). We consider both, factorizable and nonfactorizable contributions at leading power in the {Lambda}/m{sub b} expansion and to first order in the strong coupling constant {alpha}{sub s}, neglecting contributions from 3-particle distribution amplitudes in the B-meson. We pay particular attention to various sources of parametric and systematic uncertainties. We also discuss certain form factor ratios where part of the hadronic uncertainties related to the B-meson distribution amplitude and to logarithmically enhanced {alpha}{sub s} corrections cancel.

  9. $$B\\to\\pi\\ell\\ell$$ Form Factors for New-Physics Searches from Lattice QCD

    DOE PAGES

    Bailey, Jon A.

    2015-10-07

    The rare decay B→πℓ+ℓ- arises from b→d flavor-changing neutral currents and could be sensitive to physics beyond the standard model. Here, we present the first ab initio QCD calculation of the B→π tensor form factor fT. Together with the vector and scalar form factors f+ and f0 from our companion work [J. A. Bailey et al., Phys. Rev. D 92, 014024 (2015)], these parametrize the hadronic contribution to B→π semileptonic decays in any extension of the standard model. We obtain the total branching ratio BR(B+→π+μ+μ-)=20.4(2.1)×10-9 in the standard model, which is the most precise theoretical determination to date, and agreesmore » with the recent measurement from the LHCb experiment [R. Aaij et al., J. High Energy Phys. 12 (2012) 125].« less

  10. Renormalization versus strong form factors for one-boson-exchange potentials

    NASA Astrophysics Data System (ADS)

    Calle Cordón, A.; Ruiz Arriola, E.

    2010-04-01

    We analyze the one-boson-exchange potential from the point of view of renormalization theory. We show that the nucleon-meson Lagrangian, while predicting the NN force, does not predict the NN scattering matrix nor the deuteron properties unambiguously due to the appearance of short distance singularities. While the problem has traditionally been circumvented by introducing vertex functions via phenomenological strong form factors, we propose to impose physical renormalization conditions on the scattering amplitude at low energies. Working in the large Nc approximation with π, σ, ρ, and ω mesons we show that, once these conditions are applied, results for low-energy phases of proton-neutron scattering as well as deuteron properties become largely insensitive to the form factors and to the vector mesons yielding reasonable agreement with the data and for realistic values of the coupling constants.

  11. High-precision calculation of the strange nucleon electromagnetic form factors

    SciTech Connect

    Green, Jeremy; Meinel, Stefan; Engelhardt, Michael G.; Krieg, Stefan; Laeuchli, Jesse; Negele, John W.; Orginos, Kostas; Pochinsky, Andrew; Syritsyn, Sergey

    2015-08-26

    We report a direct lattice QCD calculation of the strange nucleon electromagnetic form factors GsE and GsM in the kinematic range 0 ≤ Q2 ≤ 1.2GeV2. For the first time, both GsE and GsM are shown to be nonzero with high significance. This work uses closer-to-physical lattice parameters than previous calculations, and achieves an unprecented statistical precision by implementing a recently proposed variance reduction technique called hierarchical probing. We perform model-independent fits of the form factor shapes using the z-expansion and determine the strange electric and magnetic radii and magnetic moment. As a result, we compare our results to parity-violating electron-proton scattering data and to other theoretical studies.

  12. Near-threshold neutral pion electroproduction at high momentum transfers and generalized form factors

    NASA Astrophysics Data System (ADS)

    Khetarpal, P.; Stoler, P.; Aznauryan, I. G.; Kubarovsky, V.; Adhikari, K. P.; Adikaram, D.; Aghasyan, M.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Anghinolfi, M.; Avakian, H.; Baghdasaryan, H.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; Bono, J.; Boiarinov, S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Charles, G.; Cole, P. L.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Doughty, D.; Dugger, M.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fersch, R.; Fleming, J. A.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guegan, B.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Harrison, N.; Hicks, K.; Ho, D.; Holtrop, M.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jo, H. S.; Joo, K.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Klein, F. J.; Koirala, S.; Kubarovsky, A.; Kuleshov, S. V.; Kvaltine, N. D.; Lewis, S.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Mao, Y.; Martinez, D.; Mayer, M.; McKinnon, B.; Meyer, C. A.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Moutarde, H.; Munevar, E.; Munoz Camacho, C.; Nadel-Turonski, P.; Nasseripour, R.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Pappalardo, L. L.; Paremuzyan, R.; Park, K.; Park, S.; Pasyuk, E.; Phelps, E.; Phillips, J. J.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Protopopescu, D.; Puckett, A. J. R.; Raue, B. A.; Ricco, G.; Rimal, D.; Ripani, M.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salgado, C.; Saylor, N. A.; Schott, D.; Schumacher, R. A.; Seder, E.; Seraydaryan, H.; Sharabian, Y. G.; Smith, G. D.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tang, W.; Taylor, C. E.; Tkachenko, S.; Ungaro, M.; Vernarsky, B.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zachariou, N.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2013-04-01

    We report the measurement of near-threshold neutral pion electroproduction cross sections and the extraction of the associated structure functions on the proton in the kinematic range Q2 from 2 to 4.5 GeV2 and W from 1.08 to 1.16 GeV. These measurements allow us to access the dominant pion-nucleon s-wave multipoles E0+ and S0+ in the near-threshold region. In the light-cone sum-rule framework (LCSR), these multipoles are related to the generalized form factors G1π0p(Q2) and G2π0p(Q2). The data are compared to these generalized form factors and the results for G1π0p(Q2) are found to be in good agreement with the LCSR predictions, but the level of agreement with G2π0p(Q2) is poor.

  13. Measurement of the Proton Electromagnetic Form Factors via the Spin Transfer Reaction

    SciTech Connect

    Gilles Quemener; Mark K. Jones; Charles F. Perdrisat; Vina Punjabi

    1999-08-01

    The ratio of the electromagnetic form factors of the proton has been measured at the Jefferson Laboratory at Q{sup 2} values ranging from 0.5 GeV{sup 2} up to 3.5 GeV{sup 2}. The experiment used the recently commissioned Hall A Focal Plane Polarimeter (FPP) to measure the polarization of the recoiling proton in elastic scattering of longitudinally polarized electrons on a liquid hydrogen target.

  14. A study of the N to Delta transition form factors in full QCD

    SciTech Connect

    Constantia Alexandrou; Robert Edwards; Giannis Koutsou; Theodoros Leontiou; Hartmut Neff; John W. Negele; Wolfram Schroers; Antonios Tsapalis

    2005-07-01

    The N to Delta transition form factors GM1, GE2 and GC2 are evaluated using dynamical MILC configurations and valence domain wall fermions at three values of quark mass corresponding to pion mass 606 MeV, 502 MeV and 364 MeV on lattices of spatial size 20{sup 3} and 28{sup 3}. The unquenched results are compared to those obtained at similar pion mass in the quenched theory.

  15. Bs→Dsℓν form factors and the fragmentation fraction ratio fs/fd

    NASA Astrophysics Data System (ADS)

    Monahan, Christopher J.; Na, Heechang; Bouchard, Chris M.; Lepage, G. Peter; Shigemitsu, Junko; Hpqcd Collaboration

    2017-06-01

    We present a lattice quantum chromodynamics determination of the scalar and vector form factors for the Bs→Dsℓν decay over the full physical range of momentum transfer. In conjunction with future experimental data, our results will provide a new method to extract |Vc b|, which may elucidate the current tension between exclusive and inclusive determinations of this parameter. Combining the form factor results at nonzero recoil with recent HPQCD results for the B →D ℓν form factors, we determine the ratios f0Bs→Ds(Mπ2)/f0B →D(MK2)=1.000 (62 ) and f0Bs→Ds(Mπ2)/f0B →D(Mπ2)=1.006 (62 ) . These results give the fragmentation fraction ratios fs/fd=0.310 (30 )stat(21 )syst(6 )theor(38 )latt and fs/fd=0.307 (16 )stat(21 )syst(23 )theor(44 )latt , respectively. The fragmentation fraction ratio is an important ingredient in experimental determinations of Bs meson branching fractions at hadron colliders, in particular for the rare decay B (Bs→μ+μ-). In addition to the form factor results, we make the first prediction of the branching fraction ratio R (Ds)=B (Bs→Dsτ ν )/B (Bs→Dsℓν )=0.301 (6 ) , where ℓ is an electron or muon. Current experimental measurements of the corresponding ratio for the semileptonic decays of B mesons disagree with Standard Model expectations at the level of nearly four standard deviations. Future experimental measurements of R (Ds) may help understand this discrepancy.

  16. Analytic results for planar three-loop integrals for massive form factors

    NASA Astrophysics Data System (ADS)

    Henn, Johannes M.; Smirnov, Alexander V.; Smirnov, Vladimir A.

    2016-12-01

    We use the method of differential equations to analytically evaluate all planar three-loop Feynman integrals relevant for form factor calculations involving massive particles. Our results for ninety master integrals at general q 2 are expressed in terms of multiple polylogarithms, and results for fiftyone master integrals at the threshold q 2 = 4 m 2 are expressed in terms of multiple polylogarithms of argument one, with indices equal to zero or to a sixth root of unity.

  17. Pion distribution amplitude from holographic QCD and the electromagnetic form factor Fπ(Q2)

    NASA Astrophysics Data System (ADS)

    Agaev, S. S.; Nobary, M. A. Gomshi

    2008-04-01

    The holographic QCD prediction for the pion distribution amplitude (DA) φhol(u) is used to compute the pion spacelike electromagnetic form factor Fπ(Q2) within the QCD light-cone sum rule method. In calculations the pion’s renormalon-based model twist-4 DA, as well as the asymptotic twist-4 DA are employed. Obtained theoretical predictions are compared with experimental data and with results of the holographic QCD.

  18. Measurement of the neutron electric form factor GEn in quasielastic scattering

    SciTech Connect

    Donal Day

    2003-07-15

    We have measured the electric form factor of the neutron, GEn, at two momentum transfers (Q2= 0.5 and Q2= 1.0 GeV/c2) through quasielastic scattering in Jefferson Lab's Hall C. Longitudinally polarized electrons scattered from polarized deuterated ammonia and GEn was extracted from the beam-target asymmetry AVed which, in quasielastic kinematics, is particularly sensitive to GEn and insensitive to MEC and FSI.

  19. Matter density distributions and elastic form factors of some two-neutron halo nuclei

    NASA Astrophysics Data System (ADS)

    Abdullah, Ahmed N.

    2017-09-01

    The Skyrme-Hartree-Fock (SHF) method with MSK7 Skyrme parameter has been used to investigate the ground-state properties for two-neutron halo nuclei 6He, ^{11}Li, ^{12}Be and ^{14}Be. These ground-state properties include the proton, neutron and matter density distributions, the corresponding rms radii, the binding energy per nucleon and the charge form factors. These calculations clearly reveal the long tail characterizing the halo nuclei as a distinctive feature.

  20. Nonperturbative relativistic approach to pion form factors: Predictions for future JLab experiments

    SciTech Connect

    Krutov, A. F.; Troitsky, V. E.; Tsirova, N. A.

    2009-11-15

    Some predictions concerning possible results of the future experiments at the Thomas Jefferson National Accelerator Facility (JLab) on the pion form factor F{sub {pi}}(Q{sup 2}) are made. The calculations exploit the method proposed previously by the authors and based on the instant-form Poincare invariant approach to pions, considered as quark-antiquark systems. This model has predicted with surprising accuracy the values of F{sub {pi}}(Q{sup 2}), which were measured later in JLab experiments. The results are almost independent from the form of wave function. The pion mean square radius and the decay constant f{sub {pi}} also agree with experimental values. The model gives powerlike asymptotic behavior of F{sub {pi}}(Q{sup 2}) at high momentum transfer in agreement with QCD predictions.

  1. γ*N →N*(1520 ) form factors in the timelike regime

    NASA Astrophysics Data System (ADS)

    Ramalho, G.; Peña, M. T.

    2017-01-01

    The covariant spectator quark model, tested before in a variety of electromagnetic baryon excitations, is applied here to the γ*N →N*(1520 ) reaction in the timelike regime. The transition form factors are first parametrized in the spacelike region in terms of a valence quark core model together with a parametrization of the meson cloud contribution. The form factor behavior in the timelike region is then predicted, as well as the N*(1520 )→γ N decay width and the N*(1520 ) Dalitz decay, N*(1520 )→e+e-N . Our results may help in the interpretation of dielectron production from elementary p p collisions and from the new generation of HADES results using a pion beam. In the q2=0 - 1 GeV2 range, we conclude that the QED approximation (a q2 independent form factor model) underestimates the electromagnetic coupling of the N*(1520 ) from 1 up to 2 orders of magnitude. We conclude also that the N*(1520 ) and Δ (1232 ) Dalitz decay widths are comparable.

  2. Λb→pl⁻ν¯l form factors from lattice QCD with static b quarks

    DOE PAGES

    Detmold, William; Lin, C.-J. David; Meinel, Stefan; ...

    2013-07-23

    We present a lattice QCD calculation of form factors for the decay Λb→pμ⁻ν¯μ, which is a promising channel for determining the Cabibbo-Kobayashi-Maskawa matrix element |Vub| at the Large Hadron Collider. In this initial study we work in the limit of static b quarks, where the number of independent form factors reduces to two. We use dynamical domain-wall fermions for the light quarks, and perform the calculation at two different lattice spacings and at multiple values of the light-quark masses in a single large volume. Using our form factor results, we calculate the Λb→pμ⁻ν¯μ differential decay rate in the range 14more » GeV²≤q²≤q²max, and obtain the integral ∫q²max 14 GeV²[dΓ/dq²]dq²/|Vub|²=15.3±4.2 ps⁻¹. Combined with future experimental data, this will give a novel determination of |Vub| with about 15% theoretical uncertainty. The uncertainty is dominated by the use of the static approximation for the b quark, and can be reduced further by performing the lattice calculation with a more sophisticated heavy-quark action.« less

  3. Measuerment of generalized form factors near the pion threshold in high Q^2 region with CLAS

    NASA Astrophysics Data System (ADS)

    Park, Kijun

    2010-02-01

    The recent development of experimental techniques allow us to study threshold pion production in high-energy experiments and particularly, electro-production with photon virtuality Q^2 in a few GeV^2 range. The experiments with fine energy resolution make a major step to come close to the production threshold to suppress the P-wave contribution (M1+). The recent prediction based on the Light-Cone Sum Rule (LCSR), one can calculate the hadron form factors in terms of distribution amplitudes that approach perturbative Quantum Chromo-Dynamics (pQCD) without other non-perturbative parameters in high energy regime. The extraction of the generalized form factors near the pion threshold are estimated by the S- wave multipole dominance in the LCSR framework. We extracted the generalized form factors for the first time in the exclusive channel ( ep ->en&+circ;) using CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. The kinematic ranges are from 2.05;GeV^2 to 4.5;GeV^2 for Q^2 and 1.11;GeV to 1.15;GeV for the invariant mass range in the n&+circ; system.. Preliminary results will be presented and compared with the calculation from LCSR, MAID and multipole analysis. )

  4. Partonic structure of neutral pseudoscalars via two photon transition form factors

    DOE PAGES

    Raya, Khepani; Ding, Minghui; Bashir, Adnan; ...

    2017-04-10

    Here, the γγ* → ηc,b transition form factors are computed using a continuum approach to the two valence-body bound-state problem in relativistic quantum field theory, and thereby unified with equivalent calculations of electromagnetic pion elastic and transition form factors. The resulting γγ* → ηc form factor, Gηc(Q2), is consistent with available data; significantly, at accessible momentum transfers, Q2Gηc(Q2) lies well below its conformal limit. These observations confirm that the leading-twist parton distribution amplitudes of heavy-heavy bound states are compressed relative to the conformal limit. A clear understanding of the distribution of valence quarks within mesons thus emerges, a picture whichmore » connects Goldstone modes, built from the lightest quarks in nature, with systems containing the heaviest valence quarks that can now be studied experimentally, and highlights basic facts about manifestations of mass within the Standard Model.« less

  5. Measurement of the Hadronic Form Factors in Ds to phi e nu Decays

    SciTech Connect

    Serrano, J

    2006-09-26

    Based on the measured four-dimensional rate for D{sub s}{sup +} {yields} {phi}e{sup +}{nu}{sub e} decays, they have determined the ratios of the three hadronic form factors, {tau}{sub V} = V(0)/A{sub 1}(0) = 1.636 {+-} 0.067 {+-} 0.038 and {tau}{sub 2} = A{sub 2}(0)/A{sub 1}(0) = 0.705 {+-} 0.056 {+-} 0.029, using a simple pole ansatz for the q{sup 2} dependence, with fixed values of the pole masses for both the vector and axial form factors. By a separate fit to the same data, they have also extracted the pole mass for the axial form factors, m{sub A}: {tau}{sub V} = V(0)/A{sub 1}(0) = 1.633 {+-} 0.081 {+-} 0.068, {tau}{sub 2} = A{sub 2}(0)/A{sub 1}(0) = 0.711 {+-} 0.111 {+-} 0.096 and m{sub A} = (2.53{sub -0.35}{sup +0.54} {+-} 0.54)GeV/c{sup 2}.

  6. Lattice calculation of electric dipole moments and form factors of the nucleon

    NASA Astrophysics Data System (ADS)

    Abramczyk, M.; Aoki, S.; Blum, T.; Izubuchi, T.; Ohki, H.; Syritsyn, S.

    2017-07-01

    We analyze commonly used expressions for computing the nucleon electric dipole form factors (EDFF) F3 and moments (EDM) on a lattice and find that they lead to spurious contributions from the Pauli form factor F2 due to inadequate definition of these form factors when parity mixing of lattice nucleon fields is involved. Using chirally symmetric domain wall fermions, we calculate the proton and the neutron EDFF induced by the C P -violating quark chromo-EDM interaction using the corrected expression. In addition, we calculate the electric dipole moment of the neutron using a background electric field that respects time translation invariance and boundary conditions, and we find that it decidedly agrees with the new formula but not the old formula for F3. Finally, we analyze some selected lattice results for the nucleon EDM and observe that after the correction is applied, they either agree with zero or are substantially reduced in magnitude, thus reconciling their difference from phenomenological estimates of the nucleon EDM.

  7. Accessing the Elastic Form-Factors of the $Delta(1232)$ Using the Beam-Normal Asymmetry

    SciTech Connect

    Dalton, Mark M.

    2016-08-01

    The beam-normal single-spin asymmetry, $B_n$, exists in the scattering of high energy electrons, polarized transverse to their direction of motion, from nuclear targets. To first order, this asymmetry is caused by the interference of the one-photon exchange amplitude with the imaginary part of the two-photon exchange amplitude. Measurements of $B_n$, for the production of a $\\Delta(1232)$ resonance from a proton target, will soon become available from the Qweak experiment at Jefferson Lab and the A4 experiment at Mainz. The imaginary part of two-photon exchange allows only intermediate states that are on-shell, including the $\\Delta$ itself. Therefore such data is sensitive to $\\gamma\\Delta\\Delta$, the elastic form-factors of the $\\Delta$. This article will introduce the form-factors of the $\\Delta$, discuss what might be learned about the elastic form-factors from these new data, describe ongoing efforts in calculation and measurement, and outline the possibility of future measurements.

  8. Time-like nucleon form factor measurements at overline{textbf{P}}textbf{ANDA}

    NASA Astrophysics Data System (ADS)

    Sudoł, Małgorzata

    2009-11-01

    The electromagnetic probe is an excellent tool to investigate the structure of the nucleon. The nearly 4 π detector PANDA, to be installed on the FAIR accelerator complex at Darmstadt, will allow to make a precise determination of the electromagnetic form factors of the proton in the time-like (TL) region with unprecedented precision. In the framework of the one-photon exchange, the center of mass unpolarized differential cross section of the reaction overline{p} p rightarrow e^+ e^- is a linear combination of the squared moduli of the electric Gp_E and magnetic Gp_M proton form factors. The precise measurement of the angular distribution over almost full angular range then directly gives these quantities. Only two experiments have provided the ratio R = {|Gp_E|/|Gp_M|} but with very large statistical uncertainties. Within PANDA, there is a unique opportunity to measure separately the moduli of these two proton form factors Gp_E and Gp_M in good conditions, up to around q 2 = 14 GeV2.

  9. Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome.

    PubMed

    Kumar, Veerendra; Ero, Rya; Ahmed, Tofayel; Goh, Kwok Jian; Zhan, Yin; Bhushan, Shashi; Gao, Yong-Gui

    2016-06-17

    Elongation factor 4 (EF4) is a member of the family of ribosome-dependent translational GTPase factors, along with elongation factor G and BPI-inducible protein A. Although EF4 is highly conserved in bacterial, mitochondrial, and chloroplast genomes, its exact biological function remains controversial. Here we present the cryo-EM reconstitution of the GTP form of EF4 bound to the ribosome with P and E site tRNAs at 3.8-Å resolution. Interestingly, our structure reveals an unrotated ribosome rather than a clockwise-rotated ribosome, as observed in the presence of EF4-GDP and P site tRNA. In addition, we also observed a counterclockwise-rotated form of the above complex at 5.7-Å resolution. Taken together, our results shed light on the interactions formed between EF4, the ribosome, and the P site tRNA and illuminate the GTPase activation mechanism at previously unresolved detail. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. The proton form factor measurements at Jefferson Lab, past and future

    SciTech Connect

    Punjabi, Vina A.

    2014-01-01

    Use of the double-polarization technique to obtain the elastic nucleon form factors has resulted in a dramatic improvement of the quality of two of the four nucleon electromagnetic form factors, G{sub Ep} and G{sub En}. It has also changed our understanding of the proton structure, having resulted in a distinctly different Q 2-dependence for both G{sub Ep} and G{sub Mp}, contradicting the prevailing wisdom of the 1990’s based on cross section measurements, namely that G{sub Ep} and G{sub Mp} obey a “scaling” relation {mu}G{sub Ep} ~ G{sub Mp}. A related consequence of the faster decrease of G{sub Ep} revealed by the Jefferson Lab (Jlab) polarization results was the disappearance of the early scaling F{sub 2}/F{sub 1} ~ 1/Q{sup 2} predicted by perturbative QCD. In three experiments, Gep(1), Gep(2) and Gep(3), in Halls A and C at Jlab, the ratio of the proton’s electromagnetic elastic form factors, G{sub Ep} /G{sub Mp} , was measured up to four momentum transfer Q{sup 2} of 8.5 GeV{sup 2} with high precision, using the recoil polarization technique. The initial discovery that the proton form factor ratio measured in these three experiments decreases approximately linearly with four-momentum transfer, Q{sup 2}, for values above ~ 1 GeV{sup 2}, was modified by the Gep(3) results, which suggests a slowing down of this decrease. There is an approved experiment, Gep(5), to continue these measurements to 15 GeV{sup 2}. A dedicated experimental setup, the super bigbite spectrometer (SBS), will be built for this purpose. It will be equipped with a new focal plane polarimeter to measure the polarization of the recoil protons. In this presentation, I will review the status of the proton elastic electromagnetic form factors, mention succinctly a number of theoretical approaches to describe results and show some features required for the future Gep(5) experiment.

  11. QCD Nuclear g-factor and the Spin-Statistics Theorem

    NASA Astrophysics Data System (ADS)

    Ward, Thomas

    2015-04-01

    Consideration of the composite three-quark nucleon spin structure and its Pauli spin-statistics follows a new QCD g-factor with implications for the magnetic dipole moments of nucleons and their form factors. The reformulation of the nucleon magnetic moments using the new QCD nucleon g-factor is shown to be in striking agreement with global polarized and unpolarized e-p scattering data using the Sachs electric and magnetic form factors, thus reconciling long standing discrepancies between measurements. Additionally, the introduction of QCD isospin symmetry breaking (ISB) strange quarks terms contained within the meson-baryon exchange currents allow the partially conserved EM axial currents to be restored as well as providing a precise measure of the strange quark probabilities of the nucleons. Work performed under the auspices of US Department of Energy.

  12. Factor structure and differential item functioning of the BASC-2 BESS Spanish Language Parent Form.

    PubMed

    Dever, Bridget V; Raines, Tara C; Dowdy, Erin

    2016-06-01

    Given the steady increase of students from diverse backgrounds in the U.S. educational system, in particular immigrant and Latino students, it is important to consider how to best support all students within our schools. The present study focuses on the Behavior Assessment System for Children-Second Edition (BASC-2) Behavioral and Emotional Screening System (BESS) Parent Spanish form, which is a promising assessment tool for those who are interested in screening for behavioral and emotional risk among Spanish-speaking populations. The present study included 725 students of Latino descent in Grades K-6 in an urban school district and their parents or legal guardians, who served as the informants. All parents completed the BESS language form (English or Spanish) of their choice. A confirmatory factor analysis (CFA) supported a 4-factor structure (Externalizing, Internalizing, Inattention, and Adaptive Skills) similar to that of the BESS Parent English form: χ2(77) = 248.06, p < .001; CFI = 0.903; TLI = 0.940. However, differential item functioning (DIF) analyses revealed 5 items (16.7%) demonstrated significant levels of DIF, with 4 of the 5 being easier to endorse in English. This study provides preliminary evidence of partial invariance of the BESS Parent across language forms. Although some evidence of invariance across language forms at the structural and item levels exists, more research is necessary to determine whether the DIF found in the present study results in any perceptible test bias. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  13. The biomechanical effect of shoulder remplissage combined with Bankart repair for the treatment of engaging Hill-Sachs lesions.

    PubMed

    Argintar, Evan; Heckmann, Nathanael; Wang, Lawrence; Tibone, James E; Lee, Thay Q

    2016-02-01

    The purpose of this study was to determine the biomechanical effects of the remplissage repair combined with Bankart repair for engaging Hill-Sachs lesions on range of motion (ROM), translation, and glenohumeral kinematics. Six cadaveric shoulders were tested using a custom shoulder testing system. ROM, kinematics, and anterior-posterior (AP) and superior-inferior glenohumeral translations were quantified at 0° and 60° glenohumeral abduction. Six conditions were tested: intact, Bankart lesion, Bankart with 40 % Hill-Sachs lesion, Bankart repair, Bankart repair with remplissage, and remplissage repair alone. Humeral external rotation (ER) and total range of motion increased significantly after the creation of the Bankart lesion at both 0° and 60° abduction. The Bankart repair restored ER to intact values at 0° and 60° abduction, and the addition of the remplissage repair did not significantly alter range of motion from the Bankart repair alone. AP translation increased following the creation of the Bankart and Hill-Sachs lesions and was restored with the Bankart repair; the remplissage did not alter translation from the Bankart repair alone. At maximum ER at 60° abduction, the apex of the humeral head shifted posteriorly and inferiorly with remplissage repair. The addition of the remplissage procedure combined with Bankart repair for treatment of large Hill-Sachs lesions had no statistically significant effect on ROM or translation, but altered the kinematics of the glenohumeral joint. Thus, by addressing the humeral bone defect following an anterior shoulder dislocation, the remplissage technique with concurrent Bankart repair may be a relatively minimally invasive option for converting engaging Hill-Sachs lesions to non-engaging and promoting shoulder stability, though further biomechanical and clinical studies are warranted.

  14. {gamma}*{gamma}*{yields}{pi}{sup 0} form factor from anti-de Sitter-space/QCD correspondence

    SciTech Connect

    Stoffers, Alexander; Zahed, Ismail

    2011-08-15

    The recently measured {gamma}*{gamma}*{yields}{pi}{sup 0} anomalous form factor is analyzed using the D4/D8D8 holographic approach to QCD. The half-on-shell transition form factor is vector meson dominated and is shown to exactly tie to the charged-pion form factor. The holographic result compares well with the data for the lowest vector resonance.

  15. Detection of the integrated Sachs-Wolfe effect and corresponding dark energy constraints made with directional spherical wavelets

    NASA Astrophysics Data System (ADS)

    McEwen, J. D.; Vielva, P.; Hobson, M. P.; Martínez-González, E.; Lasenby, A. N.

    2007-04-01

    Using a directional spherical wavelet analysis we detect the integrated Sachs-Wolfe (ISW) effect, indicated by a positive correlation between the first-year Wilkinson Microwave Anisotropy Probe (WMAP) and NRAO VLA Sky Survey (NVSS) data. Detections are made using both a directional extension of the spherical Mexican hat wavelet and the spherical butterfly wavelet. We examine the possibility of foreground contamination and systematics in the WMAP data and conclude that these factors are not responsible for the signal that we detect. The wavelet analysis inherently enables us to localize on the sky those regions that contribute most strongly to the correlation. On removing these localized regions the correlation that we detect is reduced in significance, as expected, but it is not eliminated, suggesting that these regions are not the sole source of correlation between the data. This finding is consistent with predictions made using the ISW effect, where one would expect weak correlations over the entire sky. In a flat universe the detection of the ISW effect provides direct and independent evidence for dark energy. We use our detection to constrain dark energy parameters by deriving a theoretical prediction for the directional wavelet covariance statistic for a given cosmological model. Comparing these predictions with the data we place constraints on the equation-of-state parameter w and the vacuum energy density ΩΛ. We also consider the case of a pure cosmological constant, that is, w = -1. For this case we rule out a zero cosmological constant at greater than the 99.9 per cent significance level. All parameter estimates that we obtain are consistent with the standard cosmological concordance model values. Although wavelets perform very well when attempting to detect the ISW effect since one may probe only the regions where the signal is present, once all information is incorporated when computing parameter estimates, the performance of the wavelet analysis is

  16. Phenomenological analysis of near-threshold periodic modulations of the proton timelike form factor

    NASA Astrophysics Data System (ADS)

    Bianconi, A.; Tomasi-Gustafsson, E.

    2016-03-01

    We have recently highlighted the presence of a periodically oscillating 10% modulation in the BABAR Collaboration data on the proton timelike form factors, expressing the deviations from the pointlike behavior of the proton-antiproton electromagnetic current in the reaction e++e-→p ¯+p . Here we deepen our previous data analysis and confirm that in the case of several standard parametrizations it is possible to write the form factor in the form F0+Fosc , where F0 is a parametrization expressing the long-range trend of the form factor (for q2 ranging from the p ¯p threshold to 36 GeV2), and Fosc is a function of the form exp(-B p )cos(C p ) , where p is the relative momentum of the final p ¯p pair. Error bars allow for a clean identification of the main features of this modulation for q2<10 GeV2 . Assuming this oscillatory modulation to be an effect of final-state interactions between the forming proton and the antiproton, we propose a phenomenological model based on a double-layer imaginary optical potential. This potential is flux absorbing when the distance between the proton and antiproton centers of mass is ≳1.7 - 1.8 fm and flux generating when it is ≲1.7 - 1.8 fm. The main features of the oscillations may be reproduced with some freedom in the potential parameters, but the transition between the two layers must be sudden (0-0.2 fm) to get the correct oscillation period. The flux-absorbing part of the p ¯p interaction is well known in the phenomenology of small-energy antiproton interactions and is due to the annihilation of p ¯p pairs into multimeson states. We interpret the flux-creating part of the potential as due to the creation of a 1 /q -ranged state when the virtual photon decays into a set of current quarks and antiquarks. This short-lived compact state may be expressed as a sum of several hadronic states including the ones with large mass Qn≫q , that may exist for a time t ˜1 /(Qn-q ) . The decay of these large-mass states leads to an

  17. Edinburgh Handedness Inventory - Short Form: a revised version based on confirmatory factor analysis.

    PubMed

    Veale, Jaimie F

    2014-01-01

    While the Edinburgh Handedness Inventory has been widely used, there have been few studies assessing its factorial validity. There is evidence that the original instructions and response options are difficult to understand. Using simplified instructions and response options, the Edinburgh Handedness Inventory was administered on a sample of 1514 participants using an online questionnaire. In accordance with previous research, a model of the 10-item inventory had poor fit for the data. This study also detected model misspecification in the previously-proposed 7-item modification. A 4-item Edinburgh Handedness Inventory - Short Form had good model fit with items modelled as both continuous and ordinal. Despite its brevity, it showed very good reliability, factor score determinacy, and correlation with scores on the 10-item inventory. By eliminating items that were modelled with considerable measurement error, the short form alleviates the concern of the 10-item inventory over-categorising mixed handers. Evidence was found for factorial invariance across level of education, age groups, and regions (USA and Australia/New Zealand). There generally appeared to be invariance across genders for the 4-item inventory. The proposed Edinburgh Handedness Inventory - Short Form measures a single handedness factor with an inventory that has brief and simple instructions and a small number of items.

  18. Clean measurements of the nucleon axial-vector and free-neutron magnetic form factors

    SciTech Connect

    Deur, Alexandre P.

    2013-11-01

    We discuss the feasibility of a weak charged current experiment using a low energy electron beam. A first goal is to measure the Q^2 dependence of the axial-vector form factor g_a(Q^2). It can be measured model-independently and as robustly as for electromagnetic form factors from typical electron scattering experiments, in contrast to the methods used so far to measure g_a(Q^2). If g_a(Q^2) follows a dipole form, the axial mass can be extracted with a better accuracy than the world data altogether. The most important detection equipment would be a segmented neutron detector with good momentum and angular resolution that is symmetric about the beam direction, and covers a moderate angular range. A high intensity beam (100 uA) is necessary. Beam polarization is highly desirable as it provides a clean measurement of the backgrounds. Beam energies between 70 and 110 MeV are ideal. This range would provide a Q^2 mapping of g_a between 0.01

  19. An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice

    PubMed Central

    Mazzone, Massimiliano; Basilico, Cristina; Cavassa, Silvia; Pennacchietti, Selma; Risio, Mauro; Naldini, Luigi; Comoglio, Paolo M.; Michieli, Paolo

    2004-01-01

    Scatter factor (SF), also known as hepatocyte growth factor, is ubiquitously present in the extracellular matrix of tissues in the form of an inactive precursor (pro-SF). In order to acquire biological activity, pro-SF must be cleaved by specific proteases present on the cell surface. The mature form of SF controls invasive cues in both physiological and pathological processes through activation of its receptor, the Met tyrosine kinase. By substituting a single amino acid in the proteolytic site, we engineered an unprocessable form of pro-SF (uncleavable SF). Using lentivirus vector technology, we achieved local or systemic delivery of uncleavable SF in mice. We provide evidence that (a) uncleavable SF inhibits both protease-mediated pro-SF conversion and active SF–induced Met activation; (b) local expression of uncleavable SF in tumors suppresses tumor growth, impairs tumor angiogenesis, and prevents metastatic dissemination; and (c) systemic expression of uncleavable SF dramatically inhibits the growth of transplanted tumors and abolishes the formation of spontaneous metastases without perturbing vital physiological functions. These data show that proteolytic activation of pro-SF is a limiting step in tumor progression, thus suggesting a new strategy for the treatment or prevention of the malignant conversion of neoplastic lesions. PMID:15545993

  20. An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice.

    PubMed

    Mazzone, Massimiliano; Basilico, Cristina; Cavassa, Silvia; Pennacchietti, Selma; Risio, Mauro; Naldini, Luigi; Comoglio, Paolo M; Michieli, Paolo

    2004-11-01

    Scatter factor (SF), also known as hepatocyte growth factor, is ubiquitously present in the extracellular matrix of tissues in the form of an inactive precursor (pro-SF). In order to acquire biological activity, pro-SF must be cleaved by specific proteases present on the cell surface. The mature form of SF controls invasive cues in both physiological and pathological processes through activation of its receptor, the Met tyrosine kinase. By substituting a single amino acid in the proteolytic site, we engineered an unprocessable form of pro-SF (uncleavable SF). Using lentivirus vector technology, we achieved local or systemic delivery of uncleavable SF in mice. We provide evidence that (a) uncleavable SF inhibits both protease-mediated pro-SF conversion and active SF-induced Met activation; (b) local expression of uncleavable SF in tumors suppresses tumor growth, impairs tumor angiogenesis, and prevents metastatic dissemination; and (c) systemic expression of uncleavable SF dramatically inhibits the growth of transplanted tumors and abolishes the formation of spontaneous metastases without perturbing vital physiological functions. These data show that proteolytic activation of pro-SF is a limiting step in tumor progression, thus suggesting a new strategy for the treatment or prevention of the malignant conversion of neoplastic lesions.