Microprocessor control of a wind turbine generator

NASA Technical Reports Server (NTRS)

Gnecco, A. J.; Whitehead, G. T.

1978-01-01

A microprocessor based system was used to control the unattended operation of a wind turbine generator. The turbine and its microcomputer system are fully described with special emphasis on the wide variety of tasks performed by the microprocessor for the safe and efficient operation of the turbine. The flexibility, cost and reliability of the microprocessor were major factors in its selection.

Fracture mechanics technology for optimum pressure vessel design.

NASA Technical Reports Server (NTRS)

Bjeletich, J. G.; Morton, T. M.

1973-01-01

A technique has been developed to design a maximum efficiency reliable pressure vessel of given geometry and service life. The technique for ensuring reliability of the minimum weight vessel relies on the application of linear elastic fracture mechanics and fracture mechanics concepts. The resultant design incorporates potential fatigue and stress corrosion crack extension during service of a worst case initial flaw. Maximum stress for safe life is specified by the design technique, thereby minimizing weight. Ratios of pressure and toughness parameters are employed to avoid arbitrary specification of design stress level which would lead to a suboptimum design.

A Fuel-Efficient Conflict Resolution Maneuver for Separation Assurance

NASA Technical Reports Server (NTRS)

Bowe, Aisha Ruth; Santiago, Confesor

2012-01-01

Automated separation assurance algorithms are envisioned to play an integral role in accommodating the forecasted increase in demand of the National Airspace System. Developing a robust, reliable, air traffic management system involves safely increasing efficiency and throughput while considering the potential impact on users. This experiment seeks to evaluate the benefit of augmenting a conflict detection and resolution algorithm to consider a fuel efficient, Zero-Delay Direct-To maneuver, when resolving a given conflict based on either minimum fuel burn or minimum delay. A total of twelve conditions were tested in a fast-time simulation conducted in three airspace regions with mixed aircraft types and light weather. Results show that inclusion of this maneuver has no appreciable effect on the ability of the algorithm to safely detect and resolve conflicts. The results further suggest that enabling the Zero-Delay Direct-To maneuver significantly increases the cumulative fuel burn savings when choosing resolution based on minimum fuel burn while marginally increasing the average delay per resolution.

Power Electronics Thermal Management Research: Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreno, Gilberto

The objective for this project is to develop thermal management strategies to enable efficient and high-temperature wide-bandgap (WBG)-based power electronic systems (e.g., emerging inverter and DC-DC converter). Reliable WBG devices are capable of operating at elevated temperatures (≥ 175 °Celsius). However, packaging WBG devices within an automotive inverter and operating them at higher junction temperatures will expose other system components (e.g., capacitors and electrical boards) to temperatures that may exceed their safe operating limits. This creates challenges for thermal management and reliability. In this project, system-level thermal analyses are conducted to determine the effect of elevated device temperatures on invertermore » components. Thermal modeling work is then conducted to evaluate various thermal management strategies that will enable the use of highly efficient WBG devices with automotive power electronic systems.« less

Operating Room of the Future: Advanced Technologies in Safe and Efficient Operating Rooms

DTIC Science & Technology

2008-10-01

fit” or compatibility with different tasks. Ideally, the optimal match between tasks and well-designed display alternatives will be self -apparent...hierarchical display environment. The FARO robot arm is used as an accurate and reliable tracker to control a virtual camera. The virtual camera pose is...in learning outcomes due to self -feedback, improvements in learning outcomes due to instructor feedback and synchronous versus asynchronous

Adaptive vehicle motion estimation and prediction

NASA Astrophysics Data System (ADS)

Zhao, Liang; Thorpe, Chuck E.

1999-01-01

Accurate motion estimation and reliable maneuver prediction enable an automated car to react quickly and correctly to the rapid maneuvers of the other vehicles, and so allow safe and efficient navigation. In this paper, we present a car tracking system which provides motion estimation, maneuver prediction and detection of the tracked car. The three strategies employed - adaptive motion modeling, adaptive data sampling, and adaptive model switching probabilities - result in an adaptive interacting multiple model algorithm (AIMM). The experimental results on simulated and real data demonstrate that our tracking system is reliable, flexible, and robust. The adaptive tracking makes the system intelligent and useful in various autonomous driving tasks.

Inherent Conservatism in Deterministic Quasi-Static Structural Analysis

NASA Technical Reports Server (NTRS)

Verderaime, V.

1997-01-01

The cause of the long-suspected excessive conservatism in the prevailing structural deterministic safety factor has been identified as an inherent violation of the error propagation laws when reducing statistical data to deterministic values and then combining them algebraically through successive structural computational processes. These errors are restricted to the applied stress computations, and because mean and variations of the tolerance limit format are added, the errors are positive, serially cumulative, and excessively conservative. Reliability methods circumvent these errors and provide more efficient and uniform safe structures. The document is a tutorial on the deficiencies and nature of the current safety factor and of its improvement and transition to absolute reliability.

Reliability of a Test Battery Designed for Quickly and Safely Assessing Diverse Indices of Neuromuscular Function

NASA Technical Reports Server (NTRS)

Spiering, Barry A.; Lee, Stuart M. C.; Mulavara, Ajitkumar P.; Bentley, Jason, R.; Buxton, Roxanne E.; Lawrence, Emily L.; Sinka, Joseph; Guilliams, Mark E.; Ploutz-Snyder, Lori L.; Bloomberg, Jacob J.

2010-01-01

Spaceflight affects nearly every physiological system. Spaceflight-induced alterations in physiological function translate to decrements in functional performance. Purpose: To develop a test battery for quickly and safely assessing diverse indices of neuromuscular performance. I. Quickly: Battery of tests can be completed in approx.30-40 min. II. Safely: a) No eccentric muscle actions or impact forces. b) Tests present little challenge to postural stability. III. Diverse indices: a) Strength: Excellent reliability (ICC = 0.99) b) Central activation: Very good reliability (ICC = 0.87) c) Power: Excellent reliability (ICC = 0.99) d) Endurance: Total work has excellent reliability (ICC = 0.99) e) Force steadiness: Poor reliability (ICC = 0.20 - 0.60) National

Recent Enhancements to the National Transonic Facility

NASA Technical Reports Server (NTRS)

Kilgore, W. A.; Balakrishna, S.; Bobbitt, C. W.; Underwood, P.

2003-01-01

The National Transonic Facility continues to make enhancements to provide quality data in a safe, efficient and cost effective method for aerodynamic ground testing. Recent enhancements discussed in this paper include the restoration of reliability and improved performance of the heat exchanger systems resulting in the expansion of the NTF air operations envelope. Additionally, results are presented from a continued effort to reduce model dynamics through the use of a new stiffer balance and sting

Achieving High Reliability with People, Processes, and Technology.

PubMed

Saunders, Candice L; Brennan, John A

2017-01-01

High reliability as a corporate value in healthcare can be achieved by meeting the "Quadruple Aim" of improving population health, reducing per capita costs, enhancing the patient experience, and improving provider wellness. This drive starts with the board of trustees, CEO, and other senior leaders who ingrain high reliability throughout the organization. At WellStar Health System, the board developed an ambitious goal to become a top-decile health system in safety and quality metrics. To achieve this goal, WellStar has embarked on a journey toward high reliability and has committed to Lean management practices consistent with the Institute for Healthcare Improvement's definition of a high-reliability organization (HRO): one that is committed to the prevention of failure, early identification and mitigation of failure, and redesign of processes based on identifiable failures. In the end, a successful HRO can provide safe, effective, patient- and family-centered, timely, efficient, and equitable care through a convergence of people, processes, and technology.

Models for Conducting Economic Analysis of Alternative Fuel Vehicles.

DTIC Science & Technology

1987-06-01

where regenerative braking is employed (5) Efficient, safe, and reliable operation (6) Overload protection for motors, motor reversing, and charging of...current to the motor in order to control the flow of power. [Ref. 3:p. 171] The regenerative braking mentioned in (4) above is a means of charging the...recovered electrically and used to charge the battery, thus extending the range of the vehicle. In regenerative braking , the electric vehicle’s V 23 AA Sg

Design Development Test and Evaluation (DDT and E) Considerations for Safe and Reliable Human Rated Spacecraft Systems

NASA Technical Reports Server (NTRS)

Miller, James; Leggett, Jay; Kramer-White, Julie

2008-01-01

A team directed by the NASA Engineering and Safety Center (NESC) collected methodologies for how best to develop safe and reliable human rated systems and how to identify the drivers that provide the basis for assessing safety and reliability. The team also identified techniques, methodologies, and best practices to assure that NASA can develop safe and reliable human rated systems. The results are drawn from a wide variety of resources, from experts involved with the space program since its inception to the best-practices espoused in contemporary engineering doctrine. This report focuses on safety and reliability considerations and does not duplicate or update any existing references. Neither does it intend to replace existing standards and policy.

Critical issues in assuring long lifetime and fail-safe operation of optical communications network

NASA Astrophysics Data System (ADS)

Paul, Dilip K.

1993-09-01

Major factors in assuring long lifetime and fail-safe operation in optical communications networks are reviewed in this paper. Reliable functionality to design specifications, complexity of implementation, and cost are the most critical issues. As economics is the driving force to set the goals as well as priorities for the design, development, safe operation, and maintenance schedules of reliable networks, a balance is sought between the degree of reliability enhancement, cost, and acceptable outage of services. Protecting both the link and the network with high reliability components, hardware duplication, and diversity routing can ensure the best network availability. Case examples include both fiber optic and lasercom systems. Also, the state-of-the-art reliability of photonics in space environment is presented.

Novel high-density packaging of solid state diode pumped eye-safe laser for LIBS

NASA Astrophysics Data System (ADS)

Bares, Kim; Torgerson, Justin; McNeil, Laine; Maine, Patrick; Patterson, Steve

2018-02-01

Laser-Induced Breakdown Spectroscopy (LIBS) has proven to be a useful research tool for material analysis for decades. However, because of the amount of energy required in a few nanosecond pulse to generate a stable and reliable LIBS signal, the lasers are often large and inefficient, relegating their implementation to research facilities, factory floors, and assembly lines. Small portable LIBS systems are now possible without having to compromise on energy needs by leveraging off of advances in high-density packaging of electronics, opto-mechanics, and highly efficient laser resonator architecture. This paper explores the integration of these techniques to achieve a mJ class eye-safe LIBS laser source, while retaining a small, light-weight package suitable for handheld systems.

Human-In-The-Loop Simulation in Support of Long-Term Sustainability of Light Water Reactors

DOE PAGES

Hallbert, Bruce P

2015-01-01

Reliable instrumentation, information, and control systems technologies are essential to ensuring safe and efficient operation of the U.S. light water reactor (LWR) fleet. These technologies affect every aspect of nuclear power plant (NPP) and balance-of-plant operations. In 1997, the National Research Council conducted a study concerning the challenges involved in modernization of digital instrumentation and control systems in NPPs. Their findings identified the need for new II&C technology integration. The NPP owners and operators realize that this analog technology represents a significant challenge to sustaining the operation of the current fleet of NPPs. Beyond control systems, new technologies are neededmore » to monitor and characterize the effects of aging and degradation in critical areas of key structures, systems, and components. The objective of the efforts sponsored by the U.S. Department of Energy is to develop, demonstrate, and deploy new digital technologies for II&C architectures and provide monitoring capabilities to ensure the continued safe, reliable, and economic operation of the nation’s NPPs.« less

Light Water Reactor Sustainability Program Advanced Instrumentation, Information, and Control Systems Technologies Technical Program Plan for FY 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hallbert, Bruce Perry; Thomas, Kenneth David

2015-10-01

Reliable instrumentation, information, and control (II&C) systems technologies are essential to ensuring safe and efficient operation of the U.S. light water reactor (LWR) fleet. These technologies affect every aspect of nuclear power plant (NPP) and balance-of-plant operations. In 1997, the National Research Council conducted a study concerning the challenges involved in modernization of digital instrumentation and control systems in NPPs. Their findings identified the need for new II&C technology integration.

Methodology to identify risk-significant components for inservice inspection and testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, M.T.; Hartley, R.S.; Jones, J.L. Jr.

1992-08-01

Periodic inspection and testing of vital system components should be performed to ensure the safe and reliable operation of Department of Energy (DOE) nuclear processing facilities. Probabilistic techniques may be used to help identify and rank components by their relative risk. A risk-based ranking would allow varied DOE sites to implement inspection and testing programs in an effective and cost-efficient manner. This report describes a methodology that can be used to rank components, while addressing multiple risk issues.

Online Cable Tester and Rerouter

NASA Technical Reports Server (NTRS)

Lewis, Mark; Medelius, Pedro

2012-01-01

Hardware and algorithms have been developed to transfer electrical power and data connectivity safely, efficiently, and automatically from an identified damaged/defective wire in a cable to an alternate wire path. The combination of online cable testing capabilities, along with intelligent signal rerouting algorithms, allows the user to overcome the inherent difficulty of maintaining system integrity and configuration control, while autonomously rerouting signals and functions without introducing new failure modes. The incorporation of this capability will increase the reliability of systems by ensuring system availability during operations.

Inherently safe in situ uranium recovery

DOEpatents

Krumhansl, James L; Brady, Patrick V

2014-04-29

An in situ recovery of uranium operation involves circulating reactive fluids through an underground uranium deposit. These fluids contain chemicals that dissolve the uranium ore. Uranium is recovered from the fluids after they are pumped back to the surface. Chemicals used to accomplish this include complexing agents that are organic, readily degradable, and/or have a predictable lifetime in an aquifer. Efficiency is increased through development of organic agents targeted to complexing tetravalent uranium rather than hexavalent uranium. The operation provides for in situ immobilization of some oxy-anion pollutants under oxidizing conditions as well as reducing conditions. The operation also artificially reestablishes reducing conditions on the aquifer after uranium recovery is completed. With the ability to have the impacted aquifer reliably remediated, the uranium recovery operation can be considered inherently safe.

Self-Assembled Peptide-Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery.

PubMed

Yan, Jin; He, Wangxiao; Yan, Siqi; Niu, Fan; Liu, Tianya; Ma, Bohan; Shao, Yongping; Yan, Yuwei; Yang, Guang; Lu, Wuyuan; Du, Yaping; Lei, Bo; Ma, Peter X

2018-02-27

Developing a sophisticated nanomedicine platform to deliver therapeutics effectively and safely into tumor/cancer cells remains challenging in the field of nanomedicine. In particular, reliable peptide drug delivery systems capable of overcoming biological barriers are still lacking. Here, we developed a simple, rapid, and robust strategy to manufacture nanoclusters of ∼90 nm in diameter that are self-assembled from lanthanide-doped nanoparticles (5 nm), two anticancer peptides with different targets (BIM and PMI), and one cyclic peptide iNGR targeted to cancer cells. The peptide-lanthanide nanoclusters (LDC-PMI-BIM-iNGR) enhanced the resistance of peptide drugs to proteolysis, disassembled in response to reductive conditions that are present in the tumor microenvironment and inhibited cancer cell growth in vitro and in vivo. Notably, LDC-PMI-BIM-iNGR exhibited extremely low systemic toxicity and side effects in vivo. Thus, the peptide-lanthanide nanocluster may serve as an ideal multifunctional platform for safe, targeted, and efficient peptide drug delivery in cancer therapy.

Test-retest reliability of the safe driving behavior measure for community-dwelling elderly drivers.

PubMed

Song, Chiang-Soon; Lee, Joo-Hyun; Han, Sang-Woo

2016-06-01

[Purpose] The Safe Driving Behavior Measure (SDBM) is a self-report measurement tools that assesses the safe-driving behaviors of the elderly. The purpose of this study was to evaluate the test-retest reliability of the SDBM among community-dwelling elderly drivers. [Subjects and Methods] A total of sixty-one community-dwelling elderly were enrolled to investigate the reliability of the SDBM. The SDBM was assessed in two sessions that were conducted three days apart in a quiet and well-organized assessment room. That test-retest reliability of overall scores and three domain scores of the SDBM were statistically evaluated using intraclass correlation coefficients [ICC (2.1)]. Pearson correlation coefficients were used to quantify bivariate associations among the three domains of the SDBM. [Results] The SDBM demonstrated excellent rest-retest reliability for community-dwelling elderly drivers. The Cronbach alpha coefficients of the three domains of person-vehicle (0.979), person-environment (0.944), and person-vehicle-environment (0.971) of the SDBM indicate high internal consistency. [Conclusion] The results of this study suggest that the SDBM is a reliable measure for evaluating the safe- driving of automobiles by community-dwelling elderly, and is adequate for detecting changes in scores in clinical settings.

A comparison of reliability and conventional estimation of safe fatigue life and safe inspection intervals

NASA Technical Reports Server (NTRS)

Hooke, F. H.

1972-01-01

Both the conventional and reliability analyses for determining safe fatigue life are predicted on a population having a specified (usually log normal) distribution of life to collapse under a fatigue test load. Under a random service load spectrum, random occurrences of load larger than the fatigue test load may confront and cause collapse of structures which are weakened, though not yet to the fatigue test load. These collapses are included in reliability but excluded in conventional analysis. The theory of risk determination by each method is given, and several reasonably typical examples have been worked out, in which it transpires that if one excludes collapse through exceedance of the uncracked strength, the reliability and conventional analyses gave virtually identical probabilities of failure or survival.

76 FR 8628 - Safe, Efficient Use and Preservation of the Navigable Airspace; OMB Approval of Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-15

...-25002; Amendment No. 77-13] RIN 2120-AH31 Safe, Efficient Use and Preservation of the Navigable Airspace... on July 21, 2010, entitled Safe, Efficient Use and Preservation of the Navigable Airspace. DATES: The..., 2010, the final rule entitled Safe, Efficient Use and Preservation of the Navigable Airspace, was...

Study of fail-safe abort system for an actively cooled hypersonic aircraft, volume 2

NASA Technical Reports Server (NTRS)

Peeples, M. E.; Herring, R. L.

1976-01-01

Conceptual designs of a fail-safe abort system for hydrogen fueled actively cooled high speed aircraft are examined. The fail-safe concept depends on basically three factors: (1) a reliable method of detecting a failure or malfunction in the active cooling system, (2) the optimization of abort trajectories which minimize the descent heat load to the aircraft, and (3) fail-safe thermostructural concepts to minimize both the weight and the maximum temperature the structure will reach during descent. These factors are examined and promising approaches are evaluated based on weight, reliability, ease of manufacture and cost.

Status of modular RTG technology

NASA Astrophysics Data System (ADS)

Hartman, Robert F.

Radioisotope thermoelectric generators (RTGs) have been employed safely and reliably since 1961 to provide spacecraft electrical power for various NASA and Department of Defense missions. Historically, RTG development, fabrication and qualification have been performed under the sponsorship of the Department of Energy's Office of Special Nuclear Projects and its predecessor groups. RTG technology improvement programs have been conducted over the years by the DOE to improve RTG efficiency and operating performance. The modular RTG design concept resulted from such a program and is currently being developed by the General Electric Company for the DOE.

Nd-YAG laser with a fibertom system in the treatment of intrauterine lesions

NASA Astrophysics Data System (ADS)

Wilczak, Maciej; Wozniak, Jakub; Sajdak, Stefan; Dydowicz, Piotr; Opala, Tomasz; Cwojdzinski, Marek; Pisarski, Tadeusz

1997-10-01

The results of 31 Nd:YAG hysteroscopic laser surgeries done in the Department of Reproduction, Institute of Gynecology and obstetrics, Karon Marcinkowski School of Medical Sciences, Poznan, Poland were describe. In nine patients the uterine septa and in 22 women the intrauterine adhesion were recognized. Hysteroscopy is a very useful and reliable method in diagnosis and treatment of intrauterine lesions reducing fertility. The laser resection of intrauterine lesions in women with malreproduction is an efficient and safe method. The fertility and parity after laser surgery are highly improved.

The state-of-the-art of dc power distribution systems/components for space applications

NASA Technical Reports Server (NTRS)

Krauthamer, S.

1988-01-01

This report is a survey of the state of the art of high voltage dc systems and components. This information can be used for consideration of an alternative secondary distribution (120 Vdc) system for the Space Station. All HVdc components have been prototyped or developed for terrestrial, aircraft, and spacecraft applications, and are applicable for general space application with appropriate modification and qualification. HVdc systems offer a safe, reliable, low mass, high efficiency and low EMI alternative for Space Station secondary distribution.

Human germline genetic modification: scientific and bioethical perspectives.

PubMed

Smith, Kevin R; Chan, Sarah; Harris, John

2012-10-01

The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering technology suggest that human germline genetic modification (HGGM) will become a safe and effective prospect in the relatively near future. Several substantive ethical objections have been raised against HGGM including claims of unacceptably high levels of risk, damage to the status of future persons, and violations of justice and autonomy. This paper critically reviews the latest GM science and discusses the key ethical objections to HGGM. We conclude that major benefits are likely to accrue through the use of safe and effective HGGM and that it would thus be unethical to take a precautionary stance against HGGM. Copyright © 2012 IMSS. Published by Elsevier Inc. All rights reserved.

Reliable assessment of general surgeons' non-technical skills based on video-recordings of patient simulated scenarios.

PubMed

Spanager, Lene; Beier-Holgersen, Randi; Dieckmann, Peter; Konge, Lars; Rosenberg, Jacob; Oestergaard, Doris

2013-11-01

Nontechnical skills are essential for safe and efficient surgery. The aim of this study was to evaluate the reliability of an assessment tool for surgeons' nontechnical skills, Non-Technical Skills for Surgeons dk (NOTSSdk), and the effect of rater training. A 1-day course was conducted for 15 general surgeons in which they rated surgeons' nontechnical skills in 9 video recordings of scenarios simulating real intraoperative situations. Data were gathered from 2 sessions separated by a 4-hour training session. Interrater reliability was high for both pretraining ratings (Cronbach's α = .97) and posttraining ratings (Cronbach's α = .98). There was no statistically significant development in assessment skills. The D study showed that 2 untrained raters or 1 trained rater was needed to obtain generalizability coefficients >.80. The high pretraining interrater reliability indicates that videos were easy to rate and Non-Technical Skills for Surgeons dk easy to use. This implies that Non-Technical Skills for Surgeons dk (NOTSSdk) could be an important tool in surgical training, potentially improving safety and quality for surgical patients. Copyright © 2013 Elsevier Inc. All rights reserved.

Reliability in individual monitoring service.

PubMed

Mod Ali, N

2011-03-01

As a laboratory certified to ISO 9001:2008 and accredited to ISO/IEC 17025, the Secondary Standard Dosimetry Laboratory (SSDL)-Nuclear Malaysia has incorporated an overall comprehensive system for technical and quality management in promoting a reliable individual monitoring service (IMS). Faster identification and resolution of issues regarding dosemeter preparation and issuing of reports, personnel enhancement, improved customer satisfaction and overall efficiency of laboratory activities are all results of the implementation of an effective quality system. Review of these measures and responses to observed trends provide continuous improvement of the system. By having these mechanisms, reliability of the IMS can be assured in the promotion of safe behaviour at all levels of the workforce utilising ionising radiation facilities. Upgradation of in the reporting program through a web-based e-SSDL marks a major improvement in Nuclear Malaysia's IMS reliability on the whole. The system is a vital step in providing a user friendly and effective occupational exposure evaluation program in the country. It provides a higher level of confidence in the results generated for occupational dose monitoring of the IMS, thus, enhances the status of the radiation protection framework of the country.

Oil-free centrifugal hydrogen compression technology demonstration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heshmat, Hooshang

2014-05-31

One of the key elements in realizing a mature market for hydrogen vehicles is the deployment of a safe and efficient hydrogen production and delivery infrastructure on a scale that can compete economically with current fuels. The challenge, however, is that hydrogen, being the lightest and smallest of gases with a lower viscosity and density than natural gas, readily migrates through small spaces and is difficult to compresses efficiently. While efficient and cost effective compression technology is crucial to effective pipeline delivery of hydrogen, the compression methods used currently rely on oil lubricated positive displacement (PD) machines. PD compression technologymore » is very costly, has poor reliability and durability, especially for components subjected to wear (e.g., valves, rider bands and piston rings) and contaminates hydrogen with lubricating fluid. Even so called “oil-free” machines use oil lubricants that migrate into and contaminate the gas path. Due to the poor reliability of PD compressors, current hydrogen producers often install duplicate units in order to maintain on-line times of 98-99%. Such machine redundancy adds substantially to system capital costs. As such, DOE deemed that low capital cost, reliable, efficient and oil-free advanced compressor technologies are needed. MiTi’s solution is a completely oil-free, multi-stage, high-speed, centrifugal compressor designed for flow capacity of 500,000 kg/day with a discharge pressure of 1200 psig. The design employs oil-free compliant foil bearings and seals to allow for very high operating speeds, totally contamination free operation, long life and reliability. This design meets the DOE’s performance targets and achieves an extremely aggressive, specific power metric of 0.48 kW-hr/kg and provides significant improvements in reliability/durability, energy efficiency, sealing and freedom from contamination. The multi-stage compressor system concept has been validated through full scale performance testing of a single stage with helium similitude gas at full speed in accordance with ASME PTC-10. The experimental results indicated that aerodynamic performance, with respect to compressor discharge pressure, flow, power and efficiency exceeded theoretical prediction. Dynamic testing of a simulated multistage centrifugal compressor was also completed under a parallel program to validate the integrity and viability of the system concept. The results give strong confidence in the feasibility of the multi-stage design for use in hydrogen gas transportation and delivery from production locations to point of use.« less

HOME - An application of fault-tolerant techniques and system self-testing. [independent computer for helicopter flight control command monitoring

NASA Technical Reports Server (NTRS)

Holden, D. G.

1975-01-01

Hard Over Monitoring Equipment (HOME) has been designed to complement and enhance the flight safety of a flight research helicopter. HOME is an independent, highly reliable, and fail-safe special purpose computer that monitors the flight control commands issued by the flight control computer of the helicopter. In particular, HOME detects the issuance of a hazardous hard-over command for any of the four flight control axes and transfers the control of the helicopter to the flight safety pilot. The design of HOME incorporates certain reliability and fail-safe enhancement design features, such as triple modular redundancy, majority logic voting, fail-safe dual circuits, independent status monitors, in-flight self-test, and a built-in preflight exerciser. The HOME design and operation is described with special emphasis on the reliability and fail-safe aspects of the design.

Improved Performance and Safety for High Energy Batteries Through Use of Hazard Anticipation and Capacity Prediction

NASA Technical Reports Server (NTRS)

Atwater, Terrill

1993-01-01

Prediction of the capacity remaining in used high rate, high energy batteries is important information to the user. Knowledge of the capacity remaining in used batteries results in better utilization. This translates into improved readiness and cost savings due to complete, efficient use. High rate batteries, due to their chemical nature, are highly sensitive to misuse (i.e., over discharge or very high rate discharge). Battery failure due to misuse or manufacturing defects could be disastrous. Since high rate, high energy batteries are expensive and energetic, a reliable method of predicting both failures and remaining energy has been actively sought. Due to concerns over safety, the behavior of lithium/sulphur dioxide cells at different temperatures and current drains was examined. The main thrust of this effort was to determine failure conditions for incorporation in hazard anticipation circuitry. In addition, capacity prediction formulas have been developed from test data. A process that performs continuous, real-time hazard anticipation and capacity prediction was developed. The introduction of this process into microchip technology will enable the production of reliable, safe, and efficient high energy batteries.

Study of a fail-safe abort system for an actively cooled hypersonic aircraft. Volume 1: Technical summary

NASA Technical Reports Server (NTRS)

Pirello, C. J.; Herring, R. L.

1976-01-01

Conceptual designs of a fail-safe abort system for hydrogen fueled actively cooled high speed aircraft are examined. The fail-safe concept depends on basically three factors: (1) a reliable method of detecting a failure or malfunction in the active cooling system, (2) the optimization of abort trajectories which minimize the descent heat load to the aircraft, and (3) fail-safe thermostructural concepts to minimize both the weight and the maximum temperature the structure will reach during descent. These factors are examined and promising approaches are evaluated based on weight, reliability, ease of manufacture and cost.

Photovoltaic power system reliability considerations

NASA Technical Reports Server (NTRS)

Lalli, V. R.

1980-01-01

An example of how modern engineering and safety techniques can be used to assure the reliable and safe operation of photovoltaic power systems is presented. This particular application is for a solar cell power system demonstration project designed to provide electric power requirements for remote villages. The techniques utilized involve a definition of the power system natural and operating environment, use of design criteria and analysis techniques, an awareness of potential problems via the inherent reliability and FMEA methods, and use of fail-safe and planned spare parts engineering philosophy.

Photovoltaic power system reliability considerations

NASA Technical Reports Server (NTRS)

Lalli, V. R.

1980-01-01

This paper describes an example of how modern engineering and safety techniques can be used to assure the reliable and safe operation of photovoltaic power systems. This particular application was for a solar cell power system demonstration project in Tangaye, Upper Volta, Africa. The techniques involve a definition of the power system natural and operating environment, use of design criteria and analysis techniques, an awareness of potential problems via the inherent reliability and FMEA methods, and use of a fail-safe and planned spare parts engineering philosophy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Nam-Gyu; Grätzel, Michael; Miyasaka, Tsutomu

Solar cells employing a halide perovskite with an organic cation now show power conversion efficiency of up to 22%. But, these cells are facing issues towards commercialization, such as the need to achieve long-term stability and the development of a manufacturing method for the reproducible fabrication of high-performance devices. We propose a strategy to obtain stable and commercially viable perovskite solar cells. A reproducible manufacturing method is suggested, as well as routes to manage grain boundaries and interfacial charge transport. Electroluminescence is regarded as a metric to gauge theoretical efficiency. We highlight how optimizing the design of device architectures ismore » important not only for achieving high efficiency but also for hysteresis-free and stable performance. Here, we argue that reliable device characterization is needed to ensure the advance of this technology towards practical applications. We believe that perovskite-based devices can be competitive with silicon solar modules, and discuss issues related to the safe management of toxic material.« less

Evaluating "The Safe Living Guide": A Home Hazard Checklist for Seniors

ERIC Educational Resources Information Center

Sorcinelli, Andrea; Shaw, Lynn; Freeman, Andrew; Cooper, Kim

2007-01-01

Purpose: The purpose of this study was to evaluate the utility and reliability of a home hazard checklist published in Health Canada, "The Safe Living Guide: A Guide to Home Safety for Seniors" (2003). Methods: 76 community-dwelling seniors evaluated the guide, and inter-rater reliability was determined through comparison of ratings of…

Reliability and Validity of a Questionnaire to Measure Consumer Knowledge regarding Safe Practices to Prevent Microbiological Contamination in Restaurants

ERIC Educational Resources Information Center

Uggioni, Paula Lazzarin; Salay, Elisabette

2013-01-01

Objective: The objective of this study was to develop a validated and reliable questionnaire to measure consumer knowledge regarding safe practices to prevent microbiological contamination in restaurants and commercial kitchens. Methods: Non-probabilistic samples of individuals were interviewed in the city of Campinas, Brazil. Questionnaire items…

A Statistical Simulation Approach to Safe Life Fatigue Analysis of Redundant Metallic Components

NASA Technical Reports Server (NTRS)

Matthews, William T.; Neal, Donald M.

1997-01-01

This paper introduces a dual active load path fail-safe fatigue design concept analyzed by Monte Carlo simulation. The concept utilizes the inherent fatigue life differences between selected pairs of components for an active dual path system, enhanced by a stress level bias in one component. The design is applied to a baseline design; a safe life fatigue problem studied in an American Helicopter Society (AHS) round robin. The dual active path design is compared with a two-element standby fail-safe system and the baseline design for life at specified reliability levels and weight. The sensitivity of life estimates for both the baseline and fail-safe designs was examined by considering normal and Weibull distribution laws and coefficient of variation levels. Results showed that the biased dual path system lifetimes, for both the first element failure and residual life, were much greater than for standby systems. The sensitivity of the residual life-weight relationship was not excessive at reliability levels up to R = 0.9999 and the weight penalty was small. The sensitivity of life estimates increases dramatically at higher reliability levels.

The Small Aircraft Transportation System (SATS): Research Collaborations with the NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Tarry, Scott E.; Bowen, Brent D.; Nickerson, Jocelyn S.

2002-01-01

The aviation industry is an integral part of the world s economy. Travelers have consistently chosen aviation as their mode of transportation as it is reliable, time efficient and safe. The out- dated Hub and Spoke system, coupled with high demand, has led to delays, cancellations and gridlock. NASA is developing innovative solutions to these and other air transportation problems. This research is being conducted through partnerships with federal agencies, industry stakeholders, and academia, specifically the University of Nebraska at Omaha. Each collaborator is pursuing the NASA General Aviation Roadmap through their involvement in the expansion of the Small Aircraft Transportation System (SATS). SATS will utilize technologically advanced small aircraft to transport travelers to and from rural and isolated communities. Additionally, this system will provide a safe alternative to the hub and spoke system, giving more time to more people through high-speed mobility and increased accessibility.

An aqueous rechargeable formate-based hydrogen battery driven by heterogeneous Pd catalysis.

PubMed

Bi, Qing-Yuan; Lin, Jian-Dong; Liu, Yong-Mei; Du, Xian-Long; Wang, Jian-Qiang; He, He-Yong; Cao, Yong

2014-12-01

The formate-based rechargeable hydrogen battery (RHB) promises high reversible capacity to meet the need for safe, reliable, and sustainable H2 storage used in fuel cell applications. Described herein is an additive-free RHB which is based on repetitive cycles operated between aqueous formate dehydrogenation (discharging) and bicarbonate hydrogenation (charging). Key to this truly efficient and durable H2 handling system is the use of highly strained Pd nanoparticles anchored on graphite oxide nanosheets as a robust and efficient solid catalyst, which can facilitate both the discharging and charging processes in a reversible and highly facile manner. Up to six repeated discharging/charging cycles can be performed without noticeable degradation in the storage capacity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Early surgical suction and washout for treatment of cytotoxic drug extravasations.

PubMed

Vandeweyer, E; Deraemaecker, R

2000-02-01

This case report is presented to assess safety and efficiency of early suction and saline washout of extravasated cytotoxic drugs. Through multiple small skin incisions, the area of extravasation is first suctioned and subsequently extensively washed out with saline. Incisions are left open and the arm is elevated for 24 hours. A complete healing was obtained in five days without any skin or soft tissue loss. No additional treatment was needed. Early referral and surgical treatment by suction and washout is a safe and reliable treatment protocol for major cytotoxic drug extravasation injuries.

A simple technique of laparoscopic port closure allowing wound extension.

PubMed

Christey, G R; Poole, G

2002-04-01

Reliable and safe access to the abdominal cavity and efficient removal of the resected gallbladder are essential to laparoscopic cholecystectomy. The unpredictable size of the cholecystectomy specimen can sometimes lead to frustration at the time of removal. A simple technique has been developed that allows for tissue extraction and easy fascial closure regardless of the size of the specimen. This is achieved by using a four bite "U-shaped" purse string at the time of Hasson insertion, with cephalad advancement of the proximal two bites. This allows for variable wound extension and secure closure, without the need for additional sutures.

Using the Social, Attitudinal, Familial, and Environmental (S.A.F.E.) Acculturation Stress Scale to Assess the Adjustment Needs of Hispanic College Students.

ERIC Educational Resources Information Center

Fuertes, Jairo N.; Westbrook, Franklin D.

1996-01-01

Reexamined the validity and reliability of the 24-item S.A.F.E. scale and found it to be a reliable measure of Hispanics' acculturation stress. Also studied the effect of generational status, gender, and socioeconomic status on the levels of acculturation stress experienced by this sample. (RJM)

Willingness to pay for safe drinking water: Evidence from Parral, Mexico.

PubMed

Vásquez, William F; Mozumder, Pallab; Hernández-Arce, Jesús; Berrens, Robert P

2009-08-01

A referendum-format contingent valuation (CV) survey is used to elicit household willingness to pay responses for safe and reliable drinking water in Parral, Mexico. Households currently adopt a variety of averting and private investment choices (e.g., bottled water consumption, home-based water treatment, and installation of water storage facilities) to adapt to the existing water supply system. These revealed behaviors indicate the latent demand for safer and more reliable water services, which is corroborated by the CV survey evidence. Validity findings include significant scope sensitivity in WTP for water services. Further, results indicate that households are willing to pay from 1.8% to 7.55% of reported household income above their current water bill for safe and reliable drinking water services, depending upon the assumptions about response uncertainty.

Bridging Climate Change Resilience and Mitigation in the Electricity Sector Through Renewable Energy and Energy Efficiency: Emerging Climate Change and Development Topics for Energy Sector Transformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cox, Sarah L; Hotchkiss, Elizabeth L; Bilello, Daniel E

Reliable, safe, and secure electricity is essential for economic and social development and a necessary input for many sectors of the economy. However, electricity generation and associated processes make up a significant portion of global greenhouse gas (GHG) emissions contributing to climate change. Furthermore, electricity systems are vulnerable to climate change impacts - both short-term events and changes over the longer term. This vulnerability presents both near-term and chronic challenges in providing reliable, affordable, equitable, and sustainable energy services. Within this context, developing countries face a number of challenges in the energy sector, including the need to reliably meet growingmore » electricity demand, lessen dependence on imported fuels, expand energy access, and improve stressed infrastructure for fuel supply and electricity transmission. Energy efficiency (EE) and renewable energy (RE) technical solutions described in this paper can bridge action across climate change mitigation and resilience through reducing GHG emissions and supporting electric power sector adaptation to increasing climate risk. Integrated planning approaches, also highlighted in this paper, play an integral role in bringing together mitigation and resilience action under broader frameworks. Through supporting EE and RE deployment and integrated planning approaches, unique to specific national and local circumstances, countries can design and implement policies, strategies, and sectoral plans that unite development priorities, climate change mitigation, and resilience.« less

Remote multi-function fire alarm system based on internet of things

NASA Astrophysics Data System (ADS)

Wang, Lihui; Zhao, Shuai; Huang, Jianqing; Ji, Jianyu

2018-05-01

This project uses MCU STC15W408AS (stable, energy saving, high speed), temperature sensor DS18B20 (cheap, high efficiency, stable), MQ2 resistance type semiconductor smog sensor (high stability, fast response and economy) and NRF24L01 wireless transmitting and receiving module (energy saving, small volume, reliable) as the main body to achieve concentration temperature data presentation, intelligent voice alarming and short distance wireless transmission. The whole system is safe, reliable, cheap, quick reaction and good performance. This project uses the MCU STM32F103RCT6 as the main control chip, and use WIFI module ESP8266, wireless module NRF24L01 to make the gateway. Users can remotely check and control the related devices in real-time on smartphones or computers. We can also realize the functions of intelligent fire monitoring, remote fire extinguishing, cloud data storage through the third party server Big IOT.

Boiling over: A Descriptive Analysis of Drinking Water Advisories in First Nations Communities in Ontario, Canada

PubMed Central

Galway, Lindsay P.

2016-01-01

Access to safe and reliable drinking water is commonplace for most Canadians. However, the right to safe and reliable drinking water is denied to many First Nations peoples across the country, highlighting a priority public health and environmental justice issue in Canada. This paper describes trends and characteristics of drinking water advisories, used as a proxy for reliable access to safe drinking water, among First Nations communities in the province of Ontario. Visual and statistical tools were used to summarize the advisory data in general, temporal trends, and characteristics of the drinking water systems in which advisories were issued. Overall, 402 advisories were issued during the study period. The number of advisories increased from 25 in 2004 to 75 in 2013. The average advisory duration was 294 days. Most advisories were reported in summer months and equipment malfunction was the most commonly reported reason for issuing an advisory. Nearly half of all advisories occurred in drinking water systems where additional operator training was needed. These findings underscore that the prevalence of drinking water advisories in First Nations communities is a problem that must be addressed. Concerted and multi-faceted efforts are called for to improve the provision of safe and reliable drinking water First Nations communities. PMID:27196919

Boiling over: A Descriptive Analysis of Drinking Water Advisories in First Nations Communities in Ontario, Canada.

PubMed

Galway, Lindsay P

2016-05-17

Access to safe and reliable drinking water is commonplace for most Canadians. However, the right to safe and reliable drinking water is denied to many First Nations peoples across the country, highlighting a priority public health and environmental justice issue in Canada. This paper describes trends and characteristics of drinking water advisories, used as a proxy for reliable access to safe drinking water, among First Nations communities in the province of Ontario. Visual and statistical tools were used to summarize the advisory data in general, temporal trends, and characteristics of the drinking water systems in which advisories were issued. Overall, 402 advisories were issued during the study period. The number of advisories increased from 25 in 2004 to 75 in 2013. The average advisory duration was 294 days. Most advisories were reported in summer months and equipment malfunction was the most commonly reported reason for issuing an advisory. Nearly half of all advisories occurred in drinking water systems where additional operator training was needed. These findings underscore that the prevalence of drinking water advisories in First Nations communities is a problem that must be addressed. Concerted and multi-faceted efforts are called for to improve the provision of safe and reliable drinking water First Nations communities.

Making Safe Surgery Affordable: Design of a Surgical Drill Cover System for Scale.

PubMed

Buchan, Lawrence L; Black, Marianne S; Cancilla, Michael A; Huisman, Elise S; Kooyman, Jeremy J R; Nelson, Scott C; OʼHara, Nathan N; OʼBrien, Peter J; Blachut, Piotr A

2015-10-01

Many surgeons in low-resource settings do not have access to safe, affordable, or reliable surgical drilling tools. Surgeons often resort to nonsterile hardware drills because they are affordable, robust, and efficient, but they are impossible to sterilize using steam. A promising alternative is to use a Drill Cover system (a sterilizable fabric bag plus surgical chuck adapter) so that a nonsterile hardware drill can be used safely for surgical bone drilling. Our objective was to design a safe, effective, affordable Drill Cover system for scale in low-resource settings. We designed our device based on feedback from users at Mulago Hospital (Kampala, Uganda) and focused on 3 main aspects. First, the design included a sealed barrier between the surgical field and hardware drill that withstands pressurized fluid. Second, the selected hardware drill had a maximum speed of 1050 rpm to match common surgical drills and reduce risk of necrosis. Third, the fabric cover was optimized for ease of assembly while maintaining a sterile technique. Furthermore, with the Drill Cover approach, multiple Drill Covers can be provided with a single battery-powered drill in a "kit," so that the drill can be used in back-to-back surgeries without requiring immediate sterilization. The Drill Cover design presented here provides a proof-of-concept for a product that can be commercialized, produced at scale, and used in low-resource settings globally to improve access to safe surgery.

Energy manager design for microgrids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Firestone, Ryan; Marnay, Chris

2005-01-01

On-site energy production, known as distributed energy resources (DER), offers consumers many benefits, such as bill savings and predictability, improved system efficiency, improved reliability, control over power quality, and in many cases, greener electricity. Additionally, DER systems can benefit electric utilities by reducing congestion on the grid, reducing the need for new generation and transmission capacity, and offering ancillary services such as voltage support and emergency demand response. Local aggregations of distributed energy resources (DER) that may include active control of on-site end-use energy devices can be called microgrids. Microgrids require control to ensure safe operation and to make dispatchmore » decisions that achieve system objectives such as cost minimization, reliability, efficiency and emissions requirements, while abiding by system constraints and regulatory rules. This control is performed by an energy manager (EM). Preferably, an EM will achieve operation reasonably close to the attainable optimum, it will do this by means robust to deviations from expected conditions, and it will not itself incur insupportable capital or operation and maintenance costs. Also, microgrids can include supervision over end-uses, such as curtailing or rescheduling certain loads. By viewing a unified microgrid as a system of supply and demand, rather than simply a system of on-site generation devices, the benefits of integrated supply and demand control can be exploited, such as economic savings and improved system energy efficiency.« less

Examining the Factor Structure and Reliability of the Safe Patient Handling Perception Scale: An Initial Validation Study.

PubMed

White-Heisel, Regina; Canfield, James P; Young-Hughes, Sadie

Perceiving imminent safe patient handling and movement (SPH&M) dangers may reduce musculoskeletal (MSK) injuries for nurses in the workplace. The purpose of this study is to develop and validate the 17-item Safe Patient Handling Perception Scale (SPHPS) as an evaluation instrument assessing perceptual risk of MSK injury based on SPH&M knowledge, practice, and resource accessibility in the workplace. Data were collected from a convenience sample (N = 117) of nursing employees at a Veteran Affairs Medical Center. Factor analysis identified three factors: knowledge, practice, and accessibility. The SPHPS demonstrated high levels of reliability, supported by acceptable alpha scores (SPHM knowledge [α = .866], SPHM practices [α = .901], and access to SPHM resources [α = .855]), in addition to the relatively low standard error of measurement scores (SEM). The study outcomes suggest that the SPHPS is a valid and reliable tool that can measure participants' perceived risk factors for MSK injuries.

A wireless power transmission system for implantable devices in freely moving rodents.

PubMed

Eom, Kyungsik; Jeong, Joonsoo; Lee, Tae Hyung; Kim, Jinhyung; Kim, Junghoon; Lee, Sung Eun; Kim, Sung June

2014-08-01

Reliable wireless power delivery for implantable devices in animals is highly desired for safe and effective experimental use. Batteries require frequent replacement; wired connections are inconvenient and unsafe, and short-distance inductive coupling requires the attachment of an exterior transmitter to the animal's body. In this article, we propose a solution by which animals with implantable devices can move freely without attachments. Power is transmitted using coils attached to the animal's cage and is received by a receiver coil implanted in the animal. For a three-dimensionally uniform delivery of power, we designed a columnar dual-transmitter coil configuration. A resonator-based inductive link was adopted for efficient long-range power delivery, and we used a novel biocompatible liquid crystal polymer substrate as the implantable receiver device. Using this wireless power delivery system, we obtain an average power transfer efficiency of 15.2% (minimum efficiency of 10% and a standard deviation of 2.6) within a cage of 15×20×15 cm3.

Towards stable and commercially available perovskite solar cells

DOE PAGES

Park, Nam-Gyu; Grätzel, Michael; Miyasaka, Tsutomu; ...

2016-10-17

Solar cells employing a halide perovskite with an organic cation now show power conversion efficiency of up to 22%. But, these cells are facing issues towards commercialization, such as the need to achieve long-term stability and the development of a manufacturing method for the reproducible fabrication of high-performance devices. We propose a strategy to obtain stable and commercially viable perovskite solar cells. A reproducible manufacturing method is suggested, as well as routes to manage grain boundaries and interfacial charge transport. Electroluminescence is regarded as a metric to gauge theoretical efficiency. We highlight how optimizing the design of device architectures ismore » important not only for achieving high efficiency but also for hysteresis-free and stable performance. Here, we argue that reliable device characterization is needed to ensure the advance of this technology towards practical applications. We believe that perovskite-based devices can be competitive with silicon solar modules, and discuss issues related to the safe management of toxic material.« less

Malfunctions in radioactivity sensors' networks

NASA Astrophysics Data System (ADS)

Khalipova, Veronika; Damart, Guillaume; Beauzamy, Bernard; Bruna, Giovanni

2018-01-01

The capacity to promptly and efficiently detect any source of contamination of the environment (a radioactive cloud) at a local and a country scale is mandatory to a safe and secure exploitation of civil nuclear energy. It must rely upon a robust network of measurement devices, to be optimized vs. several parameters, including the overall reliability, the investment, the operation and maintenance costs. We show that a network can be arranged in different ways, but many of them are inadequate. Through simulations, we test the efficiency of several configurations of sensors, in the same domain. The denser arrangement turns out to be the more efficient, but the efficiency is increased when sensors are non-uniformly distributed over the country, with accumulation at the borders. In the case of France, as radioactive threats are most likely to come from the East, the best solution is densifying the sensors close to the eastern border. Our approach differs from previous work because it is "failure oriented": we determine the laws of probability for all types of failures and deduce in this respect the best organization of the network.

Next generation molten NaI batteries for grid scale energy storage

NASA Astrophysics Data System (ADS)

Small, Leo J.; Eccleston, Alexis; Lamb, Joshua; Read, Andrew C.; Robins, Matthew; Meaders, Thomas; Ingersoll, David; Clem, Paul G.; Bhavaraju, Sai; Spoerke, Erik D.

2017-08-01

Robust, safe, and reliable grid-scale energy storage continues to be a priority for improved energy surety, expanded integration of renewable energy, and greater system agility required to meet modern dynamic and evolving electrical energy demands. We describe here a new sodium-based battery based on a molten sodium anode, a sodium iodide/aluminum chloride (NaI/AlCl3) cathode, and a high conductivity NaSICON (Na1+xZr2SixP3-xO12) ceramic separator. This NaI battery operates at intermediate temperatures (120-180 °C) and boasts an energy density of >150 Wh kg-1. The energy-dense NaI-AlCl3 ionic liquid catholyte avoids lifetime-limiting plating and intercalation reactions, and the use of earth-abundant elements minimizes materials costs and eliminates economic uncertainties associated with lithium metal. Moreover, the inherent safety of this system under internal mechanical failure is characterized by negligible heat or gas production and benign reaction products (Al, NaCl). Scalability in design is exemplified through evolution from 0.85 to 10 Ah (28 Wh) form factors, displaying lifetime average Coulombic efficiencies of 99.45% and energy efficiencies of 81.96% over dynamic testing lasting >3000 h. This demonstration promises a safe, cost-effective, and long-lifetime technology as an attractive candidate for grid scale storage.

Optimization of shared autonomy vehicle control architectures for swarm operations.

PubMed

Sengstacken, Aaron J; DeLaurentis, Daniel A; Akbarzadeh-T, Mohammad R

2010-08-01

The need for greater capacity in automotive transportation (in the midst of constrained resources) and the convergence of key technologies from multiple domains may eventually produce the emergence of a "swarm" concept of operations. The swarm, which is a collection of vehicles traveling at high speeds and in close proximity, will require technology and management techniques to ensure safe, efficient, and reliable vehicle interactions. We propose a shared autonomy control approach, in which the strengths of both human drivers and machines are employed in concert for this management. Building from a fuzzy logic control implementation, optimal architectures for shared autonomy addressing differing classes of drivers (represented by the driver's response time) are developed through a genetic-algorithm-based search for preferred fuzzy rules. Additionally, a form of "phase transition" from a safe to an unsafe swarm architecture as the amount of sensor capability is varied uncovers key insights on the required technology to enable successful shared autonomy for swarm operations.

Are Parents Getting it Right? A Survey of Parents' Internet Use for Children's Health Care Information.

PubMed

Pehora, Carolyne; Gajaria, Nisha; Stoute, Melyssa; Fracassa, Sonia; Serebale-O'Sullivan, Refilwe; Matava, Clyde T

2015-06-22

The use of the Internet to search for medical and health-related information is increasing and associated with concerns around quality and safety. We investigated the current use and perceptions on reliable websites for children's health information by parents. Following institutional ethics approval, we conducted a survey of parents/guardians of children presenting for day surgery. A 20-item survey instrument developed and tested by the investigators was administered. Ninety-eight percent of respondents reported that they used the Internet to search for information about their child's health. Many respondents reported beginning their search at public search engines (80%); less than 20% reported starting their search at university/hospital-based websites. Common conditions such as colds/flu, skin conditions and fever were the most frequently searched, and unique conditions directly affecting the child were second. Despite low usage levels of university/hospital-based websites for health information, the majority of respondents (74%) regarded these as providing safe, accurate, and reliable information. In contrast, only 24% of respondents regarded public search engines as providing safe and reliable information. Fifty percent of respondents reported that they cross-checked information found on the internet with a family physician. An unprecedented majority of parents and guardians are using the Internet for their child's health information. Of concern is that parents and guardians are currently not using reliable and safe sources of information. Health care providers should begin to focus on improving access to safe, accurate, and reliable information through various modalities including education, designing for multiplatform, and better search engine optimization.

Minimum Control Requirements for Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Boulange, Richard; Jones, Harry; Jones, Harry

2002-01-01

Advanced control technologies are not necessary for the safe, reliable and continuous operation of Advanced Life Support (ALS) systems. ALS systems can and are adequately controlled by simple, reliable, low-level methodologies and algorithms. The automation provided by advanced control technologies is claimed to decrease system mass and necessary crew time by reducing buffer size and minimizing crew involvement. In truth, these approaches increase control system complexity without clearly demonstrating an increase in reliability across the ALS system. Unless these systems are as reliable as the hardware they control, there is no savings to be had. A baseline ALS system is presented with the minimal control system required for its continuous safe reliable operation. This baseline control system uses simple algorithms and scheduling methodologies and relies on human intervention only in the event of failure of the redundant backup equipment. This ALS system architecture is designed for reliable operation, with minimal components and minimal control system complexity. The fundamental design precept followed is "If it isn't there, it can't fail".

An Automated Safe-to-Mate (ASTM) Tester

NASA Technical Reports Server (NTRS)

Nguyen, Phuc; Scott, Michelle; Leung, Alan; Lin, Michael; Johnson, Thomas

2013-01-01

Safe-to-mate testing is a common hardware safety practice where impedance measurements are made on unpowered hardware to verify isolation, continuity, or impedance between pins of an interface connector. A computer-based instrumentation solution has been developed to resolve issues. The ASTM is connected to the circuit under test, and can then quickly, safely, and reliably safe-to-mate the entire connector, or even multiple connectors, at the same time.

Gene transfer to promote cardiac regeneration.

PubMed

Collesi, Chiara; Giacca, Mauro

2016-12-01

There is an impelling need to develop new therapeutic strategies for patients with myocardial infarction and heart failure. Leading from the large quantity of new information gathered over the last few years on the mechanisms controlling cardiomyocyte proliferation during embryonic and fetal life, it is now possible to devise innovative therapies based on cardiac gene transfer. Different protein-coding genes controlling cell cycle progression or cardiomyocyte specification and differentiation, along with microRNA mimics and inhibitors regulating pre-natal and early post-natal cell proliferation, are amenable to transformation in potential therapeutics for cardiac regeneration. These gene therapy approaches are conceptually revolutionary, since they are aimed at stimulating the intrinsic potential of differentiated cardiac cells to proliferate, rather than relying on the implantation of exogenously expanded cells to achieve tissue regeneration. For efficient and prolonged cardiac gene transfer, vectors based on the Adeno-Associated Virus stand as safe, efficient and reliable tools for cardiac gene therapy applications.

Some aspects of strategies and solutions in accident prevention.

PubMed

Häkkinen, K

1983-04-01

Accident prevention measures are traditionally classified into technical, organizational and behavioral solutions. A review of some commonly used strategies for accident prevention illustrates some discrepancies between different approaches and the need to develop more comprehensive strategies. Several factors, including protective efficiency and disadvantages at work, must be taken into account when the solutions are evaluated. Some solutions to prevent load disengagement from cranes were evaluated. Measurements of the pressing force showed that the efficiency of the safety latch of a clamp for plate lifting is inadequate to provide protection under all exceptional lifting conditions and in all situations for which the safety latch is intended. The delay caused by the attachment of a lifting hook equipped with a safety latch was measured. The handling of some of the most reliable and technically safe latches requires additional operations and thereby limits their practical application.

Application of Solid Phase Microextraction with Gas Chromatography-Mass Spectrometry as a Rapid, Reliable, and Safe Method for Field Sampling and Analysis of Chemical Warfare Agent Precursors

DTIC Science & Technology

2005-03-01

in hair samples with analysis by GC-MS [41,42]. The research discussed here examined a polydimethylsiloxane polymer with 10% activated charcoal (PDMS...Field Sampling and Analysis of Chemical Warfare Agent Precursors” Name of Candidate: LT Douglas Parrish Doctor of Philosophy, Environmental...Microextraction with Gas Chromatography-Mass Spectrometry as a Rapid, Reliable, and Safe Method for Field Sampling and Analysis of Chemical Warfare

Alternative Fuels Data Center: Deployment of Hybrid and Plug-In Electric

Science.gov Websites

standard permit for residential charging stations that allows for quick, safe installation of electric and inspector prepare homes for safe and reliable vehicle charging. Clean Cities Project Awards The

Embracing Safe Ground Test Facility Operations and Maintenance

NASA Technical Reports Server (NTRS)

Dunn, Steven C.; Green, Donald R.

2010-01-01

Conducting integrated operations and maintenance in wind tunnel ground test facilities requires a balance of meeting due dates, efficient operation, responsiveness to the test customer, data quality, effective maintenance (relating to readiness and reliability), and personnel and facility safety. Safety is non-negotiable, so the balance must be an "and" with other requirements and needs. Pressure to deliver services faster at increasing levels of quality in under-maintained facilities is typical. A challenge for management is to balance the "need for speed" with safety and quality. It s especially important to communicate this balance across the organization - workers, with a desire to perform, can be tempted to cut corners on defined processes to increase speed. Having a lean staff can extend the time required for pre-test preparations, so providing a safe work environment for facility personnel and providing good stewardship for expensive National capabilities can be put at risk by one well-intending person using at-risk behavior. This paper documents a specific, though typical, operational environment and cites management and worker safety initiatives and tools used to provide a safe work environment. Results are presented and clearly show that the work environment is a relatively safe one, though still not good enough to keep from preventing injury. So, the journey to a zero injury work environment - both in measured reality and in the minds of each employee - continues. The intent of this paper is to provide a benchmark for others with operational environments and stimulate additional sharing and discussion on having and keeping a safe work environment.

Investigation of structural factors of safety for the space shuttle

NASA Technical Reports Server (NTRS)

1972-01-01

A study was made of the factors governing the structural design of the fully reusable space shuttle booster to establish a rational approach to select optimum structural factors of safety. The study included trade studies of structural factors of safety versus booster service life, weight, cost, and reliability. Similar trade studies can be made on other vehicles using the procedures developed. The major structural components of a selected baseline booster were studied in depth, each being examined to determine the fatigue life, safe-life, and fail-safe capabilities of the baseline design. Each component was further examined to determine its reliability and safety requirements, and the change of structural weight with factors of safety. The apparent factors of safety resulting from fatigue, safe-life, proof test, and fail-safe requirements were identified. The feasibility of reduced factors of safety for design loads such as engine thrust, which are well defined, was examined.

The potential for disinfection of separated faecal matter by urea and by peracetic acid for hygienic nutrient recycling.

PubMed

Vinnerås, B; Holmqvist, A; Bagge, E; Albihn, A; Jönsson, H

2003-09-01

No efficient, reliable, and scale independent disinfection methods for toilet waste are available today for safe recycling of plant nutrients. Therefore, two chemical treatment methods, addition of urea or of PAA (a quaternary mixture of 15% peracetic acid, 15% hydrogen peroxide and 30% acetic acid), were evaluated for disinfection of faecal matter.Degradation of the added urea resulted in 30 g of ammonia nitrogen per kilogram of treated matter and a pH increase to approximately 9.3. This produced an efficient disinfection of E. coli, Enterococcus spp., and Salmonella spp. within 3 weeks (>6log(10) reduction) and a reduction of the chemical resistant Salmonella typhimurium 28b phage, corresponding to a decimal reduction within 7.5 days. No viable Ascaris suum eggs were found after 50 days of treatment. No reduction of spore forming Clostridia spp. was observed. Urea treatment proved to be efficient for disinfection of source separated faecal matter in a scale independent method used for safe recycling of nutrients found in the faecal matter.PAA reduced all of the above indicator organisms within 12 h after application. For this faecal material, with a dry matter content of approximately 10%, an addition of 0.5-1% of PAA (active substance, corresponding to 3.3-6.7% of the Proxitane 15 used) was required before no viable organisms were found in the material. However, this was not tested for the A. suum. No viable spore-forming bacteria or phages were detected. A high rate of bacteria regrowth occurred at 0.15% dosage and 5 days of treatment. PAA is an efficient alternative for disinfection of separated faeces if a rapid treatment is needed.

Efficiency considerations for the purely tapered interference fit (TIF) abutments used in dental implants.

PubMed

Bozkaya, Dinçer; Müftü, Sinan

2004-08-01

A tapered interference fit provides a mechanically reliable retention mechanism for the implant-abutment interface in a dental implant. Understanding the mechanical properties of the tapered interface with or without a screw at the bottom has been the subject of a considerable amount of studies involving experiments and finite element (FE) analysis. In this paper, approximate closed-form formulas are developed to analyze the mechanics of a tapered interference fit. In particular, the insertion force, the efficiency, defined as the ratio of the pull-out force to insertion force, and the critical insertion depth, which causes the onset of plastic deformation, are analyzed. It is shown that the insertion force is a function of the taper angle, the contact length, the inner and outer radii of the implant, the static and the kinetic coefficients of friction, and the elastic modulii of the implant/abutment materials. The efficiency of the tapered interference fit, which is defined as the ratio of the pull-out force to insertion force, is found to be greater than one, for taper angles that are less than 6 deg when the friction coefficient is 0.3. A safe range of insertion forces has been shown to exist. The lower end of this range depends on the maximum pull-out force that may occur due to occlusion in the multiple tooth restorations and the efficiency of the system; and the upper end of this range depends on the plastic deformation of the abutment and the implant due to interference fit. It has been shown that using a small taper angle and a long contact length widens the safe range of insertion forces.

Final Report, Next-Generation Mega-Voltage Cargo-Imaging System for Cargo Conainer Inspection, March 2007

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dr. James Clayton, Ph.D., Varian Medical Systems-Security & Inspection Products; Dr. Emma Regentova, Ph.D, University of Nevada Las Vegas; Dr. Evangelos Yfantis, Ph.D., University of Nevada, Las Vegas

The UNLV Research Foundation, as the primary award recipient, teamed with Varian Medical Systems-Security & Inspection Products and the University of Nevada Las Vegas (UNLV) for the purpose of conducting research and engineering related to a "next-generation" mega-voltage imaging (MVCI) system for inspection of cargo in large containers. The procurement and build-out of hardware for the MVCI project has been completed. The K-9 linear accelerator and an optimized X-ray detection system capable of efficiently detecting X-rays emitted from the accelerator after they have passed through the device is under test. The Office of Science financial assistance award has made possiblemore » the development of a system utilizing a technology which will have a profound positive impact on the security of U.S. seaports. The proposed project will ultimately result in critical research and development advances for the "next-generation" Linatron X-ray accelerator technology, thereby providing a safe, reliable and efficient fixed and mobile cargo inspection system, which will very significantly increase the fraction of cargo containers undergoing reliable inspection as the enter U.S. ports. Both NNSA/NA-22 and the Department of Homeland Security's Domestic Nuclear Detection Office are collaborating with UNLV and its team to make this technology available as soon as possible.« less

Event-driven visual attention for the humanoid robot iCub

PubMed Central

Rea, Francesco; Metta, Giorgio; Bartolozzi, Chiara

2013-01-01

Fast reaction to sudden and potentially interesting stimuli is a crucial feature for safe and reliable interaction with the environment. Here we present a biologically inspired attention system developed for the humanoid robot iCub. It is based on input from unconventional event-driven vision sensors and an efficient computational method. The resulting system shows low-latency and fast determination of the location of the focus of attention. The performance is benchmarked against an instance of the state of the art in robotics artificial attention system used in robotics. Results show that the proposed system is two orders of magnitude faster that the benchmark in selecting a new stimulus to attend. PMID:24379753

The new 34-meter antenna

NASA Technical Reports Server (NTRS)

Pompa, M. F.

1986-01-01

The new 34-m high efficiency Azimuth - Elevation antenna configuration, including its features, dynamic characteristics and performance at 8.4-GHz frequencies is described. The current-technology features of this antenna produce a highly reliable configuration by incorporation of a main wheel and track azimuth support, central pintle pivot bearing, close tolerance surface panels and all-welded construction. Also described are basic drive controls that, as slaved to three automatic microprocessors, provide accurate and safe control of the antenna's steering tasks. At this time antenna installations are completed at Goldstone and Canberra and have operationally supported the Voyager - Uranus encounter. A third installation is being constructed currently in Madrid and is scheduled for completion in late 1986.

Development and validation of purged thermal protection systems for liquid hydrogen fuel tanks of hypersonic vehicles

NASA Technical Reports Server (NTRS)

Helenbrook, R. D.; Colt, J. Z.

1977-01-01

An economical, lightweight, safe, efficient, reliable, and reusable insulation system was developed for hypersonic cruise vehicle hydrogen fuel tanks. Results indicate that, a nitrogen purged, layered insulation system with nonpermeable closed-cell insulation next to the cryogenic tank and a high service temperature fibrous insulation surrounding it, is potentially an attractive solution to the insulation problem. For the postulated hypersonic flight the average unit weight of the purged insulation system (including insulation, condensate and fuel boil off) is 6.31 kg/sq m (1.29 psf). Limited cyclic tests of large specimens of closed cell polymethacrylimide foam indicate it will withstand the expected thermal cycle.

Application of high performance asynchronous socket communication in power distribution automation

NASA Astrophysics Data System (ADS)

Wang, Ziyu

2017-05-01

With the development of information technology and Internet technology, and the growing demand for electricity, the stability and the reliable operation of power system have been the goal of power grid workers. With the advent of the era of big data, the power data will gradually become an important breakthrough to guarantee the safe and reliable operation of the power grid. So, in the electric power industry, how to efficiently and robustly receive the data transmitted by the data acquisition device, make the power distribution automation system be able to execute scientific decision quickly, which is the pursuit direction in power grid. In this paper, some existing problems in the power system communication are analysed, and with the help of the network technology, a set of solutions called Asynchronous Socket Technology to the problem in network communication which meets the high concurrency and the high throughput is proposed. Besides, the paper also looks forward to the development direction of power distribution automation in the era of big data and artificial intelligence.

Deicing System Protects General Aviation Aircraft

NASA Technical Reports Server (NTRS)

2007-01-01

Kelly Aerospace Thermal Systems LLC worked with researchers at Glenn Research Center on deicing technology with assistance from the Small Business Innovation Research (SBIR) program. Kelly Aerospace acquired Northcoast Technologies Ltd., a firm that had conducted work on a graphite foil heating element under a NASA SBIR contract and developed a lightweight, easy-to-install, reliable wing and tail deicing system. Kelly Aerospace engineers combined their experiences with those of the Northcoast engineers, leading to the certification and integration of a thermoelectric deicing system called Thermawing, a DC-powered air conditioner for single-engine aircraft called Thermacool, and high-output alternators to run them both. Thermawing, a reliable anti-icing and deicing system, allows pilots to safely fly through ice encounters and provides pilots of single-engine aircraft the heated wing technology usually reserved for larger, jet-powered craft. Thermacool, an innovative electric air conditioning system, uses a new compressor whose rotary pump design runs off an energy-efficient, brushless DC motor and allows pilots to use the air conditioner before the engine even starts

Ni-MH battery charger with a compensator for electric vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, H.W.; Han, C.S.; Kim, C.S.

1996-09-01

The development of a high-performance battery and safe and reliable charging methods are two important factors for commercialization of the Electric Vehicles (EV). Hyundai and Ovonic together spent many years in the research on optimum charging method for Ni-MH battery. This paper presents in detail the results of intensive experimental analysis, performed by Hyundai in collaboration with Ovonic. An on-board Ni-MH battery charger and its controller which are designed to use as a standard home electricity supply are described. In addition, a 3 step constant current recharger with the temperature and the battery aging compensator is proposed. This has amore » multi-loop algorithm function to detect its 80% and fully charged state, and carry out equalization charging control. The algorithm is focused on safety, reliability, efficiency, charging speed and thermal management (maintaining uniform temperatures within a battery pack). It is also designed to minimize the necessity for user input.« less

Rapid Modeling and Analysis Tools: Evolution, Status, Needs and Directions

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Stone, Thomas J.; Ransom, Jonathan B. (Technical Monitor)

2002-01-01

Advanced aerospace systems are becoming increasingly more complex, and customers are demanding lower cost, higher performance, and high reliability. Increased demands are placed on the design engineers to collaborate and integrate design needs and objectives early in the design process to minimize risks that may occur later in the design development stage. High performance systems require better understanding of system sensitivities much earlier in the design process to meet these goals. The knowledge, skills, intuition, and experience of an individual design engineer will need to be extended significantly for the next generation of aerospace system designs. Then a collaborative effort involving the designer, rapid and reliable analysis tools and virtual experts will result in advanced aerospace systems that are safe, reliable, and efficient. This paper discusses the evolution, status, needs and directions for rapid modeling and analysis tools for structural analysis. First, the evolution of computerized design and analysis tools is briefly described. Next, the status of representative design and analysis tools is described along with a brief statement on their functionality. Then technology advancements to achieve rapid modeling and analysis are identified. Finally, potential future directions including possible prototype configurations are proposed.

Nanostructured Bulk Thermoelectric Generator for Efficient Power Harvesting for Self-powered Sensor Networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Yanliang; Butt, Darryl; Agarwal, Vivek

2015-07-01

The objective of this Nuclear Energy Enabling Technology research project is to develop high-efficiency and reliable thermoelectric generators for self-powered wireless sensors nodes utilizing thermal energy from nuclear plant or fuel cycle. The power harvesting technology has crosscutting significance to address critical technology gaps in monitoring nuclear plants and fuel cycle. The outcomes of the project will lead to significant advancement in sensors and instrumentation technology, reducing cost, improving monitoring reliability and therefore enhancing safety. The self-powered wireless sensor networks could support the long-term safe and economical operation of all the reactor designs and fuel cycle concepts, as well asmore » spent fuel storage and many other nuclear science and engineering applications. The research is based on recent breakthroughs in high-performance nanostructured bulk (nanobulk) thermoelectric materials that enable high-efficiency direct heat-to-electricity conversion over a wide temperature range. The nanobulk thermoelectric materials that the research team at Boise State University and University of Houston has developed yield up to a 50% increase in the thermoelectric figure of merit, ZT, compared with state-of-the-art bulk counterparts. This report focuses on the selection of optimal thermoelectric materials for this project. The team has performed extensive study on two thermoelectric materials systems, i.e. the half-Heusler materials, and the Bismuth-Telluride materials. The report contains our recent research results on the fabrication, characterization and thermoelectric property measurements of these two materials.« less

SYBR safeTM efficiently replaces ethidium bromide in Aspergillus fumigatus gene disruption.

PubMed

Canela, H M S; Takami, L A; Ferreira, M E S

2017-02-08

Invasive aspergillosis is a disease responsible for high mortality rates, caused mainly by Aspergillus fumigatus. The available drugs are limited and this disease continues to occur at an unacceptable frequency. Gene disruption is essential in the search for new drug targets. An efficient protocol for A. fumigatus gene disruption was described but it requires ethidium bromide, a genotoxic agent, for DNA staining. Therefore, the present study tested SYBR safe TM , a non-genotoxic DNA stain, in A. fumigatus gene disruption protocol. The chosen gene was cipC, which has already been disrupted successfully in our laboratory. A deletion cassette was constructed in Saccharomyces cerevisiae and used in A. fumigatus transformation. There was no statistical difference between the tested DNA stains. The success rate of S. cerevisiae transformation was 63.3% for ethidium bromide and 70% for SYBR safe TM . For A. fumigatus gene disruption, the success rate for ethidium bromide was 100 and 97% for SYBR safe TM . In conclusion, SYBR safe TM efficiently replaced ethidium bromide, making this dye a safe and efficient alternative for DNA staining in A. fumigatus gene disruption.

Spring-action Apparatus for Fixation of Eyeball (SAFE): a novel, cost-effective yet simple device for ophthalmic wet-lab training.

PubMed

Ramakrishnan, Seema; Baskaran, Prabu; Fazal, Romana; Sulaiman, Syed Mohammad; Krishnan, Tiruvengada; Venkatesh, Rengaraj

2016-10-01

Achieving a formed and firm eyeball which is stably fixed in a holding device is a major challenge of surgical wet-lab training. Our innovation, the 'Spring-action Apparatus for Fixation of Eyeball (SAFE)' is a robust, simple and economical device to solve this problem. It consists of a hollow iron cylinder to which a spring-action syringe is attached. The spring-action syringe generates vacuum and enables reliable fixation of a human or animal cadaveric eye on the iron cylinder. The rise in intraocular pressure due to vacuum fixation can be varied as per need or nature of surgery being practised. A mask-fixed version of this device is also designed to train surgeons for appropriate hand positioning. An experienced surgeon performed various surgeries including manual small incision cataract surgery (MSICS), phacoemulsification, laser in situ keratomileusis (LASIK), femtosecond LASIK docking, Descemet's stripping endothelial keratoplasty, deep anterior lamellar keratoplasty, penetrating keratoplasty and trabeculectomy on this device, while a trainee surgeon practised MSICS and wound suturing. Skill-appropriate comfort level was much higher with SAFE than with conventional globe holders for both surgeons. Due to its stability, pressure adjustability, portability, cost-efficiency and simplicity, we recommend SAFE as the basic equipment for every wet lab. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Polydopamine-mediated surface modification of scaffold materials for human neural stem cell engineering.

PubMed

Yang, Kisuk; Lee, Jung Seung; Kim, Jin; Lee, Yu Bin; Shin, Heungsoo; Um, Soong Ho; Kim, Jeong Beom; Park, Kook In; Lee, Haeshin; Cho, Seung-Woo

2012-10-01

Surface modification of tissue engineering scaffolds and substrates is required for improving the efficacy of stem cell therapy by generating physicochemical stimulation promoting proliferation and differentiation of stem cells. However, typical surface modification methods including chemical conjugation or physical absorption have several limitations such as multistep, complicated procedures, surface denaturation, batch-to-batch inconsistencies, and low surface conjugation efficiency. In this study, we report a mussel-inspired, biomimetic approach to surface modification for efficient and reliable manipulation of human neural stem cell (NSC) differentiation and proliferation. Our study demonstrates that polydopamine coating facilitates highly efficient, simple immobilization of neurotrophic growth factors and adhesion peptides onto polymer substrates. The growth factor or peptide-immobilized substrates greatly enhance differentiation and proliferation of human NSCs (human fetal brain-derived NSCs and human induced pluripotent stem cell-derived NSCs) at a level comparable or greater than currently available animal-derived coating materials (Matrigel) with safety issues. Therefore, polydopamine-mediated surface modification can provide a versatile platform technology for developing chemically defined, safe, functional substrates and scaffolds for therapeutic applications of human NSCs. Copyright © 2012 Elsevier Ltd. All rights reserved.

Seismic tomography as a tool for measuring stress in mines

USGS Publications Warehouse

Scott, Douglas F.; Williams, T.J.; Denton, D.K.; Friedel, M.J.

1999-01-01

Spokane Research Center personnel have been investigating the use of seismic tomography to monitor the behavior of a rock mass, detect hazardous ground conditions and assess the mechanical integrity of a rock mass affected by mining. Seismic tomography can be a valuable tool for determining relative stress in deep, >1,220-m (>4,000-ft), underground pillars. If high-stress areas are detected, they can be destressed prior to development or they can be avoided. High-stress areas can be monitored with successive seismic surveys to determine if stress decreases to a level where development can be initiated safely. There are several benefits to using seismic tomography to identify high stress in deep underground pillars. The technique is reliable, cost-effective, efficient and noninvasive. Also, investigators can monitor large rock masses, as well as monitor pillars during the mining cycle. By identifying areas of high stress, engineers will be able to assure that miners are working in a safer environment.Spokane Research Center personnel have been investigating the use of seismic tomography to monitor the behavior of a rock mass, detect hazardous ground conditions and assess the mechanical integrity of a rock mass affected by mining. Seismic tomography can be a valuable tool for determining relative stress in deep, >1,200-m (>4,000-ft), underground pillars. If high-stress areas are detected, they can be destressed prior to development or they can be avoided. High-stress areas can be monitored with successive seismic surveys to determine if stress decreases to a level where development can be initiated safely. There are several benefits to using seismic tomography to identify high stress in deep underground pillars. The technique is reliable, cost-effective, efficient and noninvasive. Also, investigators can monitor large rock masses, as well as monitor pillars during the mining cycle. By identifying areas of high stress. engineers will be able to assure that miners are working in a safer environment.

Advanced Outage and Control Center: Strategies for Nuclear Plant Outage Work Status Capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gregory Weatherby

The research effort is a part of the Light Water Reactor Sustainability (LWRS) Program. LWRS is a research and development program sponsored by the Department of Energy, performed in close collaboration with industry to provide the technical foundations for licensing and managing the long-term, safe and economical operation of current nuclear power plants. The LWRS Program serves to help the US nuclear industry adopt new technologies and engineering solutions that facilitate the continued safe operation of the plants and extension of the current operating licenses. The Outage Control Center (OCC) Pilot Project was directed at carrying out the applied researchmore » for development and pilot of technology designed to enhance safe outage and maintenance operations, improve human performance and reliability, increase overall operational efficiency, and improve plant status control. Plant outage management is a high priority concern for the nuclear industry from cost and safety perspectives. Unfortunately, many of the underlying technologies supporting outage control are the same as those used in the 1980’s. They depend heavily upon large teams of staff, multiple work and coordination locations, and manual administrative actions that require large amounts of paper. Previous work in human reliability analysis suggests that many repetitive tasks, including paper work tasks, may have a failure rate of 1.0E-3 or higher (Gertman, 1996). With between 10,000 and 45,000 subtasks being performed during an outage (Gomes, 1996), the opportunity for human error of some consequence is a realistic concern. Although a number of factors exist that can make these errors recoverable, reducing and effectively coordinating the sheer number of tasks to be performed, particularly those that are error prone, has the potential to enhance outage efficiency and safety. Additionally, outage management requires precise coordination of work groups that do not always share similar objectives. Outage managers are concerned with schedule and cost, union workers are concerned with performing work that is commensurate with their trade, and support functions (safety, quality assurance, and radiological controls, etc.) are concerned with performing the work within the plants controls and procedures. Approaches to outage management should be designed to increase the active participation of work groups and managers in making decisions that closed the gap between competing objectives and the potential for error and process inefficiency.« less

Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats.

PubMed

Yu, Hongwei; Fischer, Gregory; Ferhatovic, Lejla; Fan, Fan; Light, Alan R; Weihrauch, Dorothee; Sapunar, Damir; Nakai, Hiroyuki; Park, Frank; Hogan, Quinn H

2013-01-01

We previously demonstrated safe and reliable gene transfer to the dorsal root ganglion (DRG) using a direct microinjection procedure to deliver recombinant adeno-associated virus (AAV) vector. In this study, we proceed to compare the in vivo transduction patterns of self-complementary (sc) AAV6 and AAV8 in the peripheral sensory pathway. A single, direct microinjection of either AAV6 or AAV8 expressing EGFP, at the adjusted titer of 2×10(9) viral particle per DRG, into the lumbar (L) 4 and L5 DRGs of adult rats resulted in efficient EGFP expression (48±20% for AAV6 and 25±4% for AAV8, mean ± SD) selectively in sensory neurons and their axonal projections 3 weeks after injection, which remained stable for up to 3 months. AAV6 efficiently transfers EGFP to all neuronal size groups without differential neurotropism, while AAV8 predominantly targets large-sized neurons. Neurons transduced with AAV6 penetrate into the spinal dorsal horn (DH) and terminate predominantly in superficial DH laminae, as well as in the dorsal columns and deeper laminae III-V. Only few AAV8-transduced afferents were evident in the superficial laminae, and spinal EGFP was mostly present in the deeper dorsal horn (lamina III-V) and dorsal columns, with substantial projections to the ventral horn. AAV6-mediated EGFP-positive nerve fibers were widely observed in the medial plantar skin of ipsilateral hindpaws. No apparent inflammation, tissue damage, or major pain behaviors were observed for either AAV serotype. Taken together, both AAV6 and AAV8 are efficient and safe vectors for transgene delivery to primary sensory neurons, but they exhibit distinct functional features. Intraganglionic delivery of AAV6 is more uniform and efficient compared to AAV8 in gene transfer to peripheral sensory neurons and their axonal processes.

Medicinal Cannabis: In Vitro Validation of Vaporizers for the Smoke-Free Inhalation of Cannabis.

PubMed

Lanz, Christian; Mattsson, Johan; Soydaner, Umut; Brenneisen, Rudolf

2016-01-01

Inhalation by vaporization is a promising application mode for cannabis in medicine. An in vitro validation of 5 commercial vaporizers was performed with THC-type and CBD-type cannabis. Gas chromatography/mass spectrometry was used to determine recoveries of total THC (THCtot) and total CBD (CBDtot) in the vapor. High-performance liquid chromatography with photodiode array detection was used for the quantitation of acidic cannabinoids in the residue and to calculate decarboxylation efficiencies. Recoveries of THCtot and CBDtot in the vapor of 4 electrically-driven vaporizers were 58.4 and 51.4%, 66.8 and 56.1%, 82.7 and 70.0% and 54.6 and 56.7% for Volcano Medic®, Plenty Vaporizer®, Arizer Solo® and DaVinci Vaporizer®, respectively. Decarboxylation efficiency was excellent for THC (≥ 97.3%) and CBD (≥ 94.6%). The gas-powered Vape-or-Smoke™ showed recoveries of THCtot and CBDtot in the vapor of 55.9 and 45.9%, respectively, and a decarboxylation efficiency of ≥ 87.7 for both cannabinoids. However, combustion of cannabis was observed with this device. Temperature-controlled, electrically-driven vaporizers efficiently decarboxylate inactive acidic cannabinoids and reliably release their corresponding neutral, active cannabinoids. Thus, they offer a promising application mode for the safe and efficient administration of medicinal cannabis.

Medicinal Cannabis: In Vitro Validation of Vaporizers for the Smoke-Free Inhalation of Cannabis

PubMed Central

Lanz, Christian; Mattsson, Johan; Soydaner, Umut; Brenneisen, Rudolf

2016-01-01

Inhalation by vaporization is a promising application mode for cannabis in medicine. An in vitro validation of 5 commercial vaporizers was performed with THC-type and CBD-type cannabis. Gas chromatography/mass spectrometry was used to determine recoveries of total THC (THCtot) and total CBD (CBDtot) in the vapor. High-performance liquid chromatography with photodiode array detection was used for the quantitation of acidic cannabinoids in the residue and to calculate decarboxylation efficiencies. Recoveries of THCtot and CBDtot in the vapor of 4 electrically-driven vaporizers were 58.4 and 51.4%, 66.8 and 56.1%, 82.7 and 70.0% and 54.6 and 56.7% for Volcano Medic®, Plenty Vaporizer®, Arizer Solo® and DaVinci Vaporizer®, respectively. Decarboxylation efficiency was excellent for THC (≥ 97.3%) and CBD (≥ 94.6%). The gas-powered Vape-or-Smoke™ showed recoveries of THCtot and CBDtot in the vapor of 55.9 and 45.9%, respectively, and a decarboxylation efficiency of ≥ 87.7 for both cannabinoids. However, combustion of cannabis was observed with this device. Temperature-controlled, electrically-driven vaporizers efficiently decarboxylate inactive acidic cannabinoids and reliably release their corresponding neutral, active cannabinoids. Thus, they offer a promising application mode for the safe and efficient administration of medicinal cannabis. PMID:26784441

The impact of hydrophobic hernia mesh coating by omega fatty acid on atraumatic fibrin sealant fixation.

PubMed

Gruber-Blum, S; Brand, J; Keibl, C; Redl, H; Fortelny, R H; May, C; Petter-Puchner, A H

2015-08-01

Fibrin sealant (FS) is a safe and efficient fixation method in open intraperitoneal hernia repair. While favourable results have been achieved with hydrophilic meshes, hydrophobic (such as Omega fatty acid coated) meshes (OFM) have not been specifically assessed so far. Atrium C-qur lite(®) mesh was tested in rats in models of open onlay and intraperitoneal hernia repair. 44 meshes (2 × 2 cm) were implanted in 30 male Sprague-Dawley rats in open (n = 2 meshes per animal) and intraperitoneal technique (IPOM; n = 1 mesh per animal). Animals were randomised to four groups: onlay and IPOM sutured vs. sealed. Follow-up was 6 weeks, sutured groups serving as controls. Evaluation criteria were mesh dislocation, adhesions and foreign body reaction. FS provided a reliable fixation in onlay technique, whereas OFM meshes dislocated in the IPOM position when sealed only. FS mesh fixation was safe with OFM meshes in open onlay repair. Intraperitoneal placement of hydrophobic meshes requires additional fixation and cannot be achieved with FS alone.

Safe and consistent method of spot-welding platinum thermocouple wires and foils for high temperature measurements.

PubMed

Orr, G; Roth, M

2012-08-01

A low-voltage (mV) electronically triggered spot welding system for fabricating fine thermocouples and thin sheets used in high-temperature characterization of materials' properties is suggested. The system is based on the capacitance discharge method with a timed trigger for obtaining reliable and consistent welds. In contrast to existing techniques based on employing high voltage DC supplies for charging the capacitor or supplies with positive and negative rails, this method uses a simple, standard dual power supply available at most of the physical laboratories or can be acquired at a low cost. In addition, an efficient and simple method of fabricating non-sticking electrodes that do not contaminate the weld area is suggested and implemented.

Columbus safety and reliability

NASA Astrophysics Data System (ADS)

Longhurst, F.; Wessels, H.

1988-10-01

Analyses carried out to ensure Columbus reliability, availability, and maintainability, and operational and design safety are summarized. Failure modes/effects/criticality is the main qualitative tool used. The main aspects studied are fault tolerance, hazard consequence control, risk minimization, human error effects, restorability, and safe-life design.

NASA Puffin Electric Tailsitter VTOL Concept

NASA Technical Reports Server (NTRS)

Moore, Mark D.

2010-01-01

Electric propulsion offers dramatic new vehicle mission capabilities, not possible with turbine or reciprocating engines; including high reliability and efficiency, low engine weight and maintenance, low cooling drag and volume required, very low noise and vibration, and zero emissions. The only penalizing characteristic of electric propulsion is the current energy storage technology level, which is set to triple over the next 5-10 years through huge new investments in this field. Most importantly, electric propulsion offers incredible new degrees of freedom in aircraft system integration to achieve unprecedented levels of aerodynamic, propulsive, control, and structural synergistic coupling. A unique characteristic of electric propulsion is that the technology is nearly scale-free, permitting small motors to be parallelized for fail-safe redundancy, or distributed across the airframe for tightly coupled interdisciplinary functionality without significant impacts in motor-controller efficiency or specific weight. Maximizing the potential benefit of electric propulsion is dependent on applying this technology to synergistic mission concepts. The vehicle missions with the most benefit include those which constrain environmental impact (or limit noise, exhaust, or emission signatures) are short range, or where large differences exist in the propulsion system sizing between takeoff and cruise conditions. Electric propulsion offers the following unique capabilities that other propulsion systems can t provide for short range Vertical Takeoff and Landing (VTOL) aircraft; elimination of engine noise and emissions, drastic reduction in engine cooling and radiated heat, drastic reduction in vehicle vibration levels, drastic improvement in reliability and operating costs, variable speed output at full power, for improved cruise efficiency at low tip-speed, elimination of high/hot sizing penalty, and reduction of engine-out penalties.

Development of Carbon Dioxide Hermitic Compressor

NASA Astrophysics Data System (ADS)

Imai, Satoshi; Oda, Atsushi; Ebara, Toshiyuki

Because of global environmental problems, the existing refrigerants are to be replaced with natural refrigerants. CO2 is one of the natural refrigerants and environmentally safe, inflammable and non-toxic refrigerant. Therefore high efficiency compressor that can operate with natural refrigerants, especially CO2, needs to be developed. We developed a prototype CO2 hermetic compressor, which is able to use in carbon dioxide refrigerating systems for practical use. The compressor has two rolling pistons, and it leads to low vibrations, low noise. In additions, two-stage compression with two cylinders is adopted, because pressure difference is too large to compress in one stage. And inner pressure of the shell case is intermediate pressure to minimize gas leakage between compressing rooms and inner space of shell case. Intermediate pressure design enabled to make the compressor smaller in size and lighter in weight. As a result, the compressor achieved high efficiency and high reliability by these technology. We plan to study heat pump water heater, cup vending machine and various applications with CO2 compressor.

77 FR 24556 - Waiver of Acceptable Risk Restriction for Launch and Reentry

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... designed to stimulate efforts by the private sector to demonstrate safe, reliable, and cost-effective space... ensure safe approach and berthing with the International Space Station, utilizing considerable fuel. In... economic growth and entrepreneurial activity through use of the space environment; (2) to encourage the...

Advanced design for lightweight structures: Review and prospects

NASA Astrophysics Data System (ADS)

Braga, Daniel F. O.; Tavares, S. M. O.; da Silva, Lucas F. M.; Moreira, P. M. G. P.; de Castro, Paulo M. S. T.

2014-08-01

Current demand for fuel efficient aircraft has been pushing the aeronautical sector to develop ever more lightweight designs while keeping safe operation and required structural strength. Along with light-weighting, new structural design concepts have also been established in order to maintain the aircraft in service for longer periods of time, with high reliability levels. All these innovations and requirements have led to deeply optimized aeronautical structures contributing to more sustainable air transport. This article reviews the major design philosophies which have been employed in aircraft structures, including safe-life, fail-safe and damage tolerance taking into account their impact on the structural design. A brief historical review is performed in order to analyse what led to the development of each philosophy. Material properties are related to each of the design philosophies. Damage tolerant design has emerged as the main structural design philosophy in aeronautics, requiring deep knowledge on materials fatigue and corrosion strength, as well as potential failure modes and non-destructive inspection techniques, particularly minimum detectable defect and scan times. A discussion on the implementation of structural health monitoring and self-healing structures within the current panorama of structures designed according to the damage tolerant philosophy is presented. This discussion is aided by a review of research on these two subjects. These two concepts show potential for further improving safety and durability of aircraft structures.

The Future of the U.S. Nuclear Weapons Program

NASA Astrophysics Data System (ADS)

Brooks, Linton F.

2007-03-01

This paper will examine our plans for the future of the U.S. nuclear weapons program including efforts to ``transform'' the stockpile and supporting infrastructure. We proceed from the premise that the United States will need a safe, secure, and reliable nuclear deterrent for the foreseeable future. Moreover, the Stockpile Stewardship Program is working. Today's stockpile---comprised of legacy warheads left over from the Cold War---is safe and reliable. That said, we see increased risk, absent nuclear testing, in assuring the long-term safety and reliability of our current stockpile. Nor is today's nuclear weapons complex sufficiently ``responsive'' to fixing technical problems in the stockpile, or to potential adverse geopolitical change. Our task is to work to ensure that the U.S. nuclear weapons enterprise, including the stockpile and supporting infrastructure, meets long-term national security needs. Our approach is to develop and field replacement warheads for the legacy stockpile---so-called Reliable Replacement Warheads (RRW)---as a means to transform both the nuclear stockpile and supporting infrastructure.

A novel Laser Ion Mobility Spectrometer

NASA Astrophysics Data System (ADS)

Göbel, J.; Kessler, M.; Langmeier, A.

2009-05-01

IMS is a well know technology within the range of security based applications. Its main advantages lie in the simplicity of measurement, along with a fast and sensitive detection method. Contemporary technology often fails due to interference substances, in conjunction with saturation effects and a low dynamic detection range. High throughput facilities, such as airports, require the analysis of many samples at low detection limits within a very short timeframe. High detection reliability is a requirement for safe and secure operation. In our present work we developed a laser based ion-mobility-sensor which shows several advantages over known IMS sensor technology. The goal of our research was to increase the sensitivity compared to the range of 63Ni based instruments. This was achieved with an optimised geometric drift tube design and a pulsed UV laser system at an efficient intensity. In this intensity range multi-photon ionisation is possible, which leads to higher selectivity in the ion-formation process itself. After high speed capturing of detection samples, a custom designed pattern recognition software toolbox provides reliable auto-detection capability with a learning algorithm and a graphical user interface.

Time-of-flight-assisted Kinect camera-based people detection for intuitive human robot cooperation in the surgical operating room.

PubMed

Beyl, Tim; Nicolai, Philip; Comparetti, Mirko D; Raczkowsky, Jörg; De Momi, Elena; Wörn, Heinz

2016-07-01

Scene supervision is a major tool to make medical robots safer and more intuitive. The paper shows an approach to efficiently use 3D cameras within the surgical operating room to enable for safe human robot interaction and action perception. Additionally the presented approach aims to make 3D camera-based scene supervision more reliable and accurate. A camera system composed of multiple Kinect and time-of-flight cameras has been designed, implemented and calibrated. Calibration and object detection as well as people tracking methods have been designed and evaluated. The camera system shows a good registration accuracy of 0.05 m. The tracking of humans is reliable and accurate and has been evaluated in an experimental setup using operating clothing. The robot detection shows an error of around 0.04 m. The robustness and accuracy of the approach allow for an integration into modern operating room. The data output can be used directly for situation and workflow detection as well as collision avoidance.

Operation of a New COTS Crystal Oscillator - CXOMHT over a Wide Temperature Range

NASA Technical Reports Server (NTRS)

Patterson, Richard; Hammoud, Ahmad

2011-01-01

Crystal oscillators are extensively used in electronic circuits to provide timing or clocking signals in data acquisition, communications links, and control systems, to name a few. They are affordable, small in size, and reliable. Because of the inherent characteristics of the crystal, the oscillator usually exhibits extreme accuracy in its output frequency within the intrinsic crystal stability. Stability of the frequency could be affected under varying load levels or other operational conditions. Temperature is one of those important factors that influence the frequency stability of an oscillator; as it does to the functionality of other electronic components. Electronics designed for use in NASA deep space and planetary exploration missions are expected to be exposed to extreme temperatures and thermal cycling over a wide range. Thus, it is important to design and develop circuits that are able to operate efficiently and reliably under in these harsh temperature environments. Most of the commercial-off-the-shelf (COTS) devices are very limited in terms of their specified operational temperature while very few custom-made commercial and military-grade parts have the ability to operate in a slightly wider range of temperature than those of the COTS parts. These parts are usually designed for operation under one temperature extreme, i.e. hot or cold, and do not address the wide swing in the operational temperature, which is typical of the space environment. For safe and successful space missions, electronic systems must therefore be designed not only to withstand the extreme temperature exposure but also to operate efficiently and reliably. This report presents the results obtained on the evaluation of a new COTS crystal oscillator under extreme temperatures.

Reassessing the Efficiency Penalty from Carbon Capture in Coal-Fired Power Plants.

PubMed

Supekar, Sarang D; Skerlos, Steven J

2015-10-20

This paper examines thermal efficiency penalties and greenhouse gas as well as other pollutant emissions associated with pulverized coal (PC) power plants equipped with postcombustion CO2 capture for carbon sequestration. We find that, depending on the source of heat used to meet the steam requirements in the capture unit, retrofitting a PC power plant that maintains its gross power output (compared to a PC power plant without a capture unit) can cause a drop in plant thermal efficiency of 11.3-22.9%-points. This estimate for efficiency penalty is significantly higher than literature values and corresponds to an increase of about 5.3-7.7 US¢/kWh in the levelized cost of electricity (COE) over the 8.4 US¢/kWh COE value for PC plants without CO2 capture. The results follow from the inclusion of mass and energy feedbacks in PC power plants with CO2 capture into previous analyses, as well as including potential quality considerations for safe and reliable transportation and sequestration of CO2. We conclude that PC power plants with CO2 capture are likely to remain less competitive than natural gas combined cycle (without CO2 capture) and on-shore wind power plants, both from a levelized and marginal COE point of view.

Study of the impact of a telematics system on safe and fuel-efficient driving in trucks.

DOT National Transportation Integrated Search

2014-04-01

A telematics system has been successfully demonstrated to be useful for improving motor carrier efficiency. In this : particular field study, the research team demonstrated that telematics can be used to monitor and improve safe : driving behavior as...

Effective Chemical Inactivation of Ebola Virus

PubMed Central

Haddock, Elaine; Feldmann, Friederike

2016-01-01

Reliable inactivation of specimens before removal from high-level biocontainment is crucial for safe operation. To evaluate efficacy of methods of chemical inactivation, we compared in vitro and in vivo approaches using Ebola virus as a surrogate pathogen. Consequently, we have established parameters and protocols leading to reliable and effective inactivation. PMID:27070504

Magnetic nanoparticles enhance adenovirus transduction in vitro and in vivo.

PubMed

Sapet, Cédric; Pellegrino, Christophe; Laurent, Nicolas; Sicard, Flavie; Zelphati, Olivier

2012-05-01

Adenoviruses are among the most powerful gene delivery systems. Even if they present low potential for oncogenesis, there is still a need for minimizing widespread delivery to avoid deleterious reactions. In this study, we investigated Magnetofection efficiency to concentrate and guide vectors for an improved targeted delivery. Magnetic nanoparticles formulations were complexed to a replication defective Adenovirus and were used to transduce cells both in vitro and in vivo. A new integrated magnetic procedure for cell sorting and genetic modification (i-MICST) was also investigated. Magnetic nanoparticles enhanced viral transduction efficiency and protein expression in a dose-dependent manner. They accelerated the transduction kinetics and allowed non-permissive cells infection. Magnetofection greatly improved adenovirus-mediated DNA delivery in vivo and provided a magnetic targeting. The i-MICST results established the efficiency of magnetic nanoparticles assisted viral transduction within cell sorting columns. The results showed that the combination of Magnetofection and Adenoviruses represents a promising strategy for gene therapy. Recently, a new integrated method to combine clinically approved magnetic cell isolation devices and genetic modification was developed. In this study, we validated that magnetic cell separation and adenoviral transduction can be accomplished in one reliable integrated and safe system.

A Dynamic Intrusion Detection System Based on Multivariate Hotelling's T2 Statistics Approach for Network Environments

PubMed Central

Avalappampatty Sivasamy, Aneetha; Sundan, Bose

2015-01-01

The ever expanding communication requirements in today's world demand extensive and efficient network systems with equally efficient and reliable security features integrated for safe, confident, and secured communication and data transfer. Providing effective security protocols for any network environment, therefore, assumes paramount importance. Attempts are made continuously for designing more efficient and dynamic network intrusion detection models. In this work, an approach based on Hotelling's T2 method, a multivariate statistical analysis technique, has been employed for intrusion detection, especially in network environments. Components such as preprocessing, multivariate statistical analysis, and attack detection have been incorporated in developing the multivariate Hotelling's T2 statistical model and necessary profiles have been generated based on the T-square distance metrics. With a threshold range obtained using the central limit theorem, observed traffic profiles have been classified either as normal or attack types. Performance of the model, as evaluated through validation and testing using KDD Cup'99 dataset, has shown very high detection rates for all classes with low false alarm rates. Accuracy of the model presented in this work, in comparison with the existing models, has been found to be much better. PMID:26357668

A Dynamic Intrusion Detection System Based on Multivariate Hotelling's T2 Statistics Approach for Network Environments.

PubMed

Sivasamy, Aneetha Avalappampatty; Sundan, Bose

2015-01-01

The ever expanding communication requirements in today's world demand extensive and efficient network systems with equally efficient and reliable security features integrated for safe, confident, and secured communication and data transfer. Providing effective security protocols for any network environment, therefore, assumes paramount importance. Attempts are made continuously for designing more efficient and dynamic network intrusion detection models. In this work, an approach based on Hotelling's T(2) method, a multivariate statistical analysis technique, has been employed for intrusion detection, especially in network environments. Components such as preprocessing, multivariate statistical analysis, and attack detection have been incorporated in developing the multivariate Hotelling's T(2) statistical model and necessary profiles have been generated based on the T-square distance metrics. With a threshold range obtained using the central limit theorem, observed traffic profiles have been classified either as normal or attack types. Performance of the model, as evaluated through validation and testing using KDD Cup'99 dataset, has shown very high detection rates for all classes with low false alarm rates. Accuracy of the model presented in this work, in comparison with the existing models, has been found to be much better.

Ares V: Designing the Heavy Lift Capability to Explore the Moon

NASA Technical Reports Server (NTRS)

Sumrall, John P.; McArthur, Craig

2007-01-01

NASA's Vision for Exploration requires a safe, efficient, reliable, and versatile launch vehicle capable ofplacing large payloads into Earth orbit for transfer to the Moon and destinations beyond. The Ares V Cargo Launch Vehicle (CaLV) will provide this heavy lift capability. The Ares V launch concept is shown. When it stands on the launch pad at Kennedy Space Center late in the next decade, the Ares V stack will be almost 360 feet fall. As currently envisioned, it will lift 136 metric tons (300,000 pounds) to a 30-by-160 nautical mile orbit at 28.5-degrees inclination, or 55 metric tons (120,000 pounds) to trans-lunar injection. This paper will cover the latest developments in the Ares V project in 2007 and discuss future activities.

Eye safe high power laser diode in the 1410-1550nm range

NASA Astrophysics Data System (ADS)

Boucart, Julien; de Largy, Brian; Kearley, Mark; Lichtenstein, Norbert

2010-02-01

The demand for high power lasers emitting in the 14xx-15xxnm range is growing for applications in fields such as medical or homeland security. We demonstrate high power laser diodes with emission at 1430, 1470 and 1560 nm. Single multimode emitters at 1470nm emit about 3.5W in CW operation. Power conversion efficiency can reach values as high as 38.5%. With this base material, single and multi-emitter fiber coupled modules are built. Additionally, bars on passive and microchannel coolers are fabricated that deliver 25W and 38W respectively in CW mode, while obtaining more than 80 W in pulsed mode. All reliability tests show an outstanding stability of the material with no signs of wearout after 3750 hrs under strong acceleration conditions.

The SAFE-T assessment tool: derivation and validation of a web-based application for point-of-care evaluation of gastroenterology fellow performance in colonoscopy.

PubMed

Kumar, Navin L; Kugener, Guillaume; Perencevich, Molly L; Saltzman, John R

2018-01-01

Attending assessment is a critical part of endoscopic education for gastroenterology fellows. The aim of this study was to develop and validate a concise assessment tool to evaluate real-time fellow performance in colonoscopy administered via a web-based application. The Skill Assessment in Fellow Endoscopy Training (SAFE-T) tool was derived as a novel 5-question evaluation tool that captures both summative and formative feedback adapted into a web-based application. A prospective study of 15 gastroenterology fellows (5 fellows each from years 1 to 3 of training) was performed using the SAFE-T tool. An independent reviewer evaluated a subset of these procedures and completed the SAFE-T tool and Mayo Colonoscopy Skills Assessment Tool (MCSAT) for reliability testing. Twenty-six faculty completed 350 SAFE-T evaluations of the 15 fellows in the study. The mean SAFE-T overall score (year 1, 2.00; year 2, 3.84; year 3, 4.28) differentiated each sequential fellow year of training (P < .0001). The mean SAFE-T overall score decreased with increasing case complexity score, with straightforward cases compared with average cases (4.07 vs 3.50, P < .0001), and average cases compared with challenging cases (3.50 vs 3.08, P = .0134). In dual-observed procedures, the SAFE-T tool showed excellent inter-rater reliability with a kappa agreement statistic of 0.898 (P < .0001). Correlation of the SAFE-T overall score with the MCSAT overall hands-on and individual motor scores was excellent (each r > 0.90, P < .0001). We developed and validated the SAFE-T assessment tool, a concise and web-based means of assessing real-time gastroenterology fellow performance in colonoscopy. Copyright © 2018 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

Non-aqueous cleaning solvent substitution

NASA Technical Reports Server (NTRS)

Meier, Gerald J.

1994-01-01

A variety of environmental, safety, and health concerns exist over use of chlorinated and fluorinated cleaning solvents. Sandia National Laboratories, Lawrence Livermore National Laboratories, and the Kansas City Division of AlliedSignal have combined efforts to focus on finding alternative cleaning solvents and processes which are effective, environmentally safe, and compliant with local, state, and federal regulations. An alternative solvent has been identified, qualified, and implemented into production of complex electronic assemblies, where aqueous and semi-aqueous cleaning processes are not allowed. Extensive compatibility studies were performed with components, piece-parts, and materials. Electrical testing and accelerated aging were used to screen for detrimental, long-term effects. A terpene, d-limonene, was selected as the solvent of choice, and it was found to be compatible with the components and materials tested. A brief history of the overall project will be presented, along with representative cleaning efficiency results, compatibility results, and residual solvent data. The electronics industry is constantly searching for proven methods and environmentally-safe materials to use in manufacturing processes. The information in this presentation will provide another option to consider on future projects for applications requiring high levels of quality, reliability, and cleanliness from non-aqueous cleaning processes.

Transient chaos and crisis phenomena in butterfly valves driven by solenoid actuators

NASA Astrophysics Data System (ADS)

Naseradinmousavi, Peiman; Nataraj, C.

2012-11-01

Chilled water systems used in the industry and on board ships are critical for safe and reliable operation. It is hence important to understand the fundamental physics of these systems. This paper focuses in particular on a critical part of the automation system, namely, actuators and valves that are used in so-called "smart valve" systems. The system is strongly nonlinear, and necessitates a nonlinear dynamic analysis to be able to predict all critical phenomena that affect effective operation and efficient design. The derived mathematical model includes electromagnetics, fluid mechanics, and mechanical dynamics. Nondimensionalization has been carried out in order to reduce the large number of parameters to a few critical independent sets to help carry out a broad parametric analysis. The system stability analysis is then carried out with the aid of the tools from nonlinear dynamic analysis. This reveals that the system is unstable in a certain region of the parameter space. The system is also shown to exhibit crisis and transient chaotic responses; this is characterized using Lyapunov exponents and power spectra. Knowledge and avoidance of these dangerous regimes is necessary for successful and safe operation.

A Preliminary Assessment of HTST Processing on Donkey Milk

PubMed Central

Antoniazzi, Sara; Gariglio, Gian Marco; Coscia, Alessandra; Bertino, Enrico; Cavallarin, Laura

2017-01-01

Due to increasing attention from consumers on non-bovine milk types, and to the increase in the number of small dairy donkey farms in Italy, farmers require more advanced and reliable processing devices, in order to guarantee a safe product of high quality. To this aim, a new small-scale High-Temperature Short-Time (HTST) pasteurizer (72 °C for 15 s), prototyped by the authors, was tested on donkey milk. The efficacy of the HTST device was tested on raw donkey milk microflora by enumeration of total aerobic bacteria, Enterobacteriaceae and Bacillus cereus. The biochemical quality was assessed by determining the protein profile by monodimensional electrophoresis and by measuring lysozyme activity. The HTST apparatus was able to reduce the total bacteria count, and to completely eradicate Enterobacteriaceae. Bacillus cereus, when present, was decreased with low efficiency. Changes in the protein profile were observed in milk pasteurized in accordance with both processes, although HTST seemed to limit casein degradation. Lysozyme activity was not substantially affected in comparison to raw donkey milk. In conclusion, a tailored small-volume HTST device could be safely applied to pasteurize donkey milk in on-farm pasteurization processes on small dairy donkey farms. PMID:29056708

A Preliminary Assessment of HTST Processing on Donkey Milk.

PubMed

Giribaldi, Marzia; Antoniazzi, Sara; Gariglio, Gian Marco; Coscia, Alessandra; Bertino, Enrico; Cavallarin, Laura

2017-10-09

Due to increasing attention from consumers on non-bovine milk types, and to the increase in the number of small dairy donkey farms in Italy, farmers require more advanced and reliable processing devices, in order to guarantee a safe product of high quality. To this aim, a new small-scale High-Temperature Short-Time (HTST) pasteurizer (72 °C for 15 s), prototyped by the authors, was tested on donkey milk. The efficacy of the HTST device was tested on raw donkey milk microflora by enumeration of total aerobic bacteria, Enterobacteriaceae and Bacillus cereus. The biochemical quality was assessed by determining the protein profile by monodimensional electrophoresis and by measuring lysozyme activity. The HTST apparatus was able to reduce the total bacteria count, and to completely eradicate Enterobacteriaceae. Bacillus cereus, when present, was decreased with low efficiency. Changes in the protein profile were observed in milk pasteurized in accordance with both processes, although HTST seemed to limit casein degradation. Lysozyme activity was not substantially affected in comparison to raw donkey milk. In conclusion, a tailored small-volume HTST device could be safely applied to pasteurize donkey milk in on-farm pasteurization processes on small dairy donkey farms.

Vapor-Compression Heat Pumps for Operation Aboard Spacecraft

NASA Technical Reports Server (NTRS)

Ruemmele, Warren; Ungar, Eugene; Cornwell, John

2006-01-01

Vapor-compression heat pumps (including both refrigerators and heat pumps) of a proposed type would be capable of operating in microgravity and would be safe to use in enclosed environments like those of spacecraft. The designs of these pumps would incorporate modifications of, and additions to, vapor-compression cycles of heat pumps now used in normal Earth gravitation, in order to ensure efficiency and reliability during all phases of operation, including startup, shutdown, nominal continuous operation, and peak operation. Features of such a design might include any or all of the following: (1) Configuring the compressor, condenser, evaporator, valves, capillary tubes (if any), and controls to function in microgravitation; (2) Selection of a working fluid that satisfies thermodynamic requirements and is safe to use in a closed crew compartment; (3) Incorporation of a solenoid valve and/or a check valve to prevent influx of liquid to the compressor upon startup (such influx could damage the compressor); (4) Use of a diode heat pipe between the cold volume and the evaporator to limit the influx of liquid to the compressor upon startup; and (5) Use of a heated block to vaporize any liquid that arrives at the compressor inlet.

Wireless online position monitoring of manual valve types for plant configuration management in nuclear power plants

DOE PAGES

Agarwal, Vivek; Buttles, John W.; Beaty, Lawrence H.; ...

2016-10-05

In the current competitive energy market, the nuclear industry is committed to lower the operations and maintenance cost; increase productivity and efficiency while maintaining safe and reliable operation. The present operating model of nuclear power plants is dependent on large technical staffs that put the nuclear industry at long-term economic disadvantage. Technology can play a key role in nuclear power plant configuration management in offsetting labor costs by automating manually performed plant activities. The technology being developed, tested, and demonstrated in this paper will enable the continued safe operation of today’s fleet of light water reactors by providing the technicalmore » means to monitor components in plants today that are only routinely monitored through manual activities. The wireless enabled valve position indicators that are the subject of this paper are able to provide a valid position indication available continuously, rather than only periodically. As a result, a real-time (online) availability of valve positions using an affordable technologies are vital to plant configuration when compared with long-term labor rates, and provide information that can be used for a variety of plant engineering, maintenance, and management applications.« less

Wireless online position monitoring of manual valve types for plant configuration management in nuclear power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, Vivek; Buttles, John W.; Beaty, Lawrence H.

In the current competitive energy market, the nuclear industry is committed to lower the operations and maintenance cost; increase productivity and efficiency while maintaining safe and reliable operation. The present operating model of nuclear power plants is dependent on large technical staffs that put the nuclear industry at long-term economic disadvantage. Technology can play a key role in nuclear power plant configuration management in offsetting labor costs by automating manually performed plant activities. The technology being developed, tested, and demonstrated in this paper will enable the continued safe operation of today’s fleet of light water reactors by providing the technicalmore » means to monitor components in plants today that are only routinely monitored through manual activities. The wireless enabled valve position indicators that are the subject of this paper are able to provide a valid position indication available continuously, rather than only periodically. As a result, a real-time (online) availability of valve positions using an affordable technologies are vital to plant configuration when compared with long-term labor rates, and provide information that can be used for a variety of plant engineering, maintenance, and management applications.« less

76 FR 2802 - Safe, Efficient Use and Preservation of the Navigable Airspace; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 77 [Docket No. FAA-2006-25002; Amendment No. 77-13-A] RIN 2120-AH31 Safe, Efficient Use and Preservation of the Navigable Airspace; Correction AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule; correction...

Calcaneal traction pin placement simplified: a cadaveric study.

PubMed

Kwon, John Y; Ellington, J Kent; Marsland, Daniel; Gupta, Sanjeev

2011-06-01

The tibial neurovascular bundle and sural nerve are at risk with errant pin placement during transcalcaneal pin placement. The purpose of this study was to determine a relative safe zone using a single osseous landmark to establish a technique applicable in the presence of trauma. We describe the neural anatomy anatomically and radiographically, giving surgeons a reliable and relatively safe technique for transcalcaneal pin placement. Twenty-four cadavers were dissected for the major medial neurovascular structures and the sural nerve. The closest distance from the neurovascular structures to the posterior inferior calcaneus was measured. The mean distance from the posterior inferior calcaneus to the closest major medial neurovascular structure was 3.4 cm (SD ± 0.36; range, 2.6 to 4.1 cm). The mean distance to the sural nerve was 3.4 cm (SD ± 0.54; range, 2.3 to 4.6 cm). According to the 95% confidence intervals, a relative safe zone of 3.1 cm as a radius from the posterior inferior calcaneus was determined. A relatively safe zone of 3.1 cm based on 95% confidence intervals as described as a radius from the posterior inferior calcaneus can be used for transcalcaneal pin placement in most cases without injury to the medial neurovascular bundle or sural nerve. However anatomic variation may result in the neurovascular bundle being within this zone. We describe a surgical technique for reliable placement of a transcalcaneal pin within this relative safe zone and a safe distance from the closest neurovascular structure.

A standard for test reliability in group research.

PubMed

Ellis, Jules L

2013-03-01

Many authors adhere to the rule that test reliabilities should be at least .70 or .80 in group research. This article introduces a new standard according to which reliabilities can be evaluated. This standard is based on the costs or time of the experiment and of administering the test. For example, if test administration costs are 7 % of the total experimental costs, the efficient value of the reliability is .93. If the actual reliability of a test is equal to this efficient reliability, the test size maximizes the statistical power of the experiment, given the costs. As a standard in experimental research, it is proposed that the reliability of the dependent variable be close to the efficient reliability. Adhering to this standard will enhance the statistical power and reduce the costs of experiments.

Performance testing of collision-avoidance system for power wheelchairs.

PubMed

Lopresti, Edmund F; Sharma, Vinod; Simpson, Richard C; Mostowy, L Casimir

2011-01-01

The Drive-Safe System (DSS) is a collision-avoidance system for power wheelchairs designed to support people with mobility impairments who also have visual, upper-limb, or cognitive impairments. The DSS uses a distributed approach to provide an add-on, shared-control, navigation-assistance solution. In this project, the DSS was tested for engineering goals such as sensor coverage, maximum safe speed, maximum detection distance, and power consumption while the wheelchair was stationary or driven by an investigator. Results indicate that the DSS provided uniform, reliable sensor coverage around the wheelchair; detected obstacles as small as 3.2 mm at distances of at least 1.6 m; and attained a maximum safe speed of 4.2 km/h. The DSS can drive reliably as close as 15.2 cm from a wall, traverse doorways as narrow as 81.3 cm without interrupting forward movement, and reduce wheelchair battery life by only 3%. These results have implications for a practical system to support safe, independent mobility for veterans who acquire multiple disabilities during Active Duty or later in life. These tests indicate that a system utilizing relatively low cost ultrasound, infrared, and force sensors can effectively detect obstacles in the vicinity of a wheelchair.

On a simulation study of cyber attacks on vehicle-to-infrastructure communication (V2I) in Intelligent Transportation System (ITS)

NASA Astrophysics Data System (ADS)

Ekedebe, Nnanna; Yu, Wei; Song, Houbing; Lu, Chao

2015-05-01

An intelligent transportation system (ITS) is one typical cyber-physical system (CPS) that aims to provide efficient, effective, reliable, and safe driving experiences with minimal congestion and effective traffic flow management. In order to achieve these goals, various ITS technologies need to work synergistically. Nonetheless, ITS's reliance on wireless connectivity makes it vulnerable to cyber threats. Thus, it is critical to understand the impact of cyber threats on ITS. In this paper, using real-world transportation dataset, we evaluated the consequences of cyber threats - attacks against service availability by jamming the communication channel of ITS. In this way, we can have a better understanding of the importance of ensuring adequate security respecting safety and life-critical ITS applications before full and expensive real-world deployments. Our experimental data shows that cyber threats against service availability could adversely affect traffic efficiency and safety performances evidenced by exacerbated travel time, fuel consumed, and other evaluated performance metrics as the communication network is compromised. Finally, we discuss a framework to make ITS secure and more resilient against cyber threats.

Reliability and validity analysis of the transfer assessment instrument.

PubMed

McClure, Laura A; Boninger, Michael L; Ozawa, Haishin; Koontz, Alicia

2011-03-01

To describe the development and evaluate the reliability and validity of a newly created outcome measure, the Transfer Assessment Instrument (TAI), to assess the quality of transfers performed by full-time wheelchair users. Repeated measures. 2009 National Veterans Wheelchair Games in Spokane, WA. A convenience sample of full-time wheelchair users (N=40) who perform sitting pivot or standing pivot transfers. Not applicable. Intraclass correlation coefficients (ICCs) for reliability and Spearman correlation coefficients for concurrent validity between the TAI and a global assessment scale (0-100 visual analog scale [VAS]). No adverse events occurred during testing. Intrarater ICCs for 3 raters ranged between .35 and .89, and the interrater ICC was .642. Correlations between the TAI and a global assessment VAS ranged between .19 (P=.285) and .69 (P>.000). Item analyses of the tool found a wide range of results, from weak to good reliability. Evaluators found the TAI to be safe and able to be completed in a short time. The TAI is a safe, quick outcome measure that uses equipment typically found in a clinical setting and does not ask participants to perform new skills. Reliability and validity testing found the TAI to have acceptable interrater and a wide range of intrarater reliability. Future work indicates the need for continued refinement including removal or modification of items found to have low reliability, improved education for clinicians, and further reliability and validity analysis with a more diverse subject population. The TAI has the potential to fill a void in assessment of transfers. Copyright © 2011 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Types and status of high reliability practices in the federal fire community (Abstract)

Treesearch

Anne Black; Brooke McBride

2012-01-01

Since emerging in the late 1980s, the paradigm of High Reliability Organizing (HRO) has sought to describe how and why certain organizations consistently function safely under hazardous conditions. Researchers have explored a variety of industrial situations, from the early observations of nuclear aircraft carrier operations to nursing units and even high-tech IPOs....

Exploration Launch Projects RS-68B Engine Requirements for NASA's Heavy Lift Ares V

NASA Technical Reports Server (NTRS)

Sumrall, John P.; McArthur, J. Craig; Lacey, Matt

2007-01-01

NASA's Vision for Exploration requires a safe, efficient, reliable, and versatile launch vehicle capable of placing large payloads into Earth orbit for transfer to the Moon and destinations beyond. The Ares V Cargo Launch Vehicle (CaLV) will provide this heavy lift capability. The Ares V launch concept is shown in Fig. 1. When it stands on the launch pad at Kennedy Space Center late in the next decade, the Ares V stack will be almost 360 feet tall. As currently envisioned, it will lift 133,000 to 144,000 pounds to trans-lunar injection, depending on the length of loiter time on Earth orbit. This presentation will provide an overview of the Constellation architecture, the Ares launch vehicles, and, specifically, the latest developments in the RS-68B engine for the Ares V.

Hawaii StreamStats; a web application for defining drainage-basin characteristics and estimating peak-streamflow statistics

USGS Publications Warehouse

Rosa, Sarah N.; Oki, Delwyn S.

2010-01-01

Reliable estimates of the magnitude and frequency of floods are necessary for the safe and efficient design of roads, bridges, water-conveyance structures, and flood-control projects and for the management of flood plains and flood-prone areas. StreamStats provides a simple, fast, and reproducible method to define drainage-basin characteristics and estimate the frequency and magnitude of peak discharges in Hawaii?s streams using recently developed regional regression equations. StreamStats allows the user to estimate the magnitude of floods for streams where data from stream-gaging stations do not exist. Existing estimates of the magnitude and frequency of peak discharges in Hawaii can be improved with continued operation of existing stream-gaging stations and installation of additional gaging stations for areas where limited stream-gaging data are available.

Value impact assessment: A preliminary assessment of improvement opportunities at the Quantico Central Heating Plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brambley, M.R.; Weakley, S.A.

1990-09-01

This report presents the results of a preliminary assessment of opportunities for improvement at the US Marine Corps (USMC) Quantico, Virginia, Central Heating Plant (CHP). This study is part of a program intended to provide the CHP staff with a computerized Artificial Intelligence (AI) decision support system that will assist in a more efficient, reliable, and safe operation of their plant. As part of the effort to provide the AI decision support system, a team of six scientists and engineers from the Pacific Northwest Laboratory (PNL) visited the plant to characterize the conditions and environment of the CHP. This assessmentmore » resulted in a list of potential performance improvement opportunities at the CHP. In this report, 12 of these opportunities are discussed and qualitatively analyzed. 70 refs., 7 figs., 6 tabs.« less

Optical frequency modulation continuous wave coherent laser radar for spacecraft safe landing vector velocity measurement

NASA Astrophysics Data System (ADS)

Sui, Xiao-lin; Zhou, Shou-huan

2013-05-01

The design and performance of Optical frequency modulation continuous wave (OFMCW) coherent laser radar is presented. By employing a combination of optical heterodyne and linear frequency modulation techniques and utilizing fiber optic technologies, highly efficient, compact and reliable laser radar suitable for operation in a space environment is being developed.We also give a hardware structure of the OFMCW coherent laser radar. We made a detailed analysis of the measurement error. Its accuracy in the speed range is less than 0.5%.Measurement results for the movement of the carrier has also made a detailed assessment. The results show that its acceleration vector has better adaptability. The circuit structure is also given a detailed design. At the end of the article, we give the actual authentication method and experimental results.

Evaluation of the safety benefits of legacy safe routes to school programs

DOT National Transportation Integrated Search

2008-08-01

This study first examined the feasibility of conducting a crash-based assessment of the safety effects of legacy Safe Routes to School : (SRTS) programs. These were SRTS programs operating before the passage of the Safe, Accountable, Flexible, Effici...

Implementation plan for safe routes to school program.

DOT National Transportation Integrated Search

2009-08-01

Section 1404 of the Safe, Accountable, Flexible, and Efficient Transportation Equity Act: A Legacy for Users (SAFETEA-LU, Public Law 109-59) establishes a national Safe Routes to School (SRTS) Program. The purpose of the program is to encourage K-8 s...

Tool and Fixture Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graham, Mark W.

2015-07-28

In a manufacturing process, a need is identified and a product is created to fill this need. While design and engineering of the final product is important, the tools and fixtures that aid in the creation of the final product are just as important, if not more so. Power supplies assembled at the TA-55 PF-5 have been designed by an excellent engineering team. The task in PF-5 now is to ensure that all steps of the assembly and manufacturing process can be completed safely, reliably, and in a quality repeatable manner. One of these process steps involves soldering fine wiresmore » to an electrical connector. During the process development phase, the method of soldering included placing the power supply in a vice in order to manipulate it into a position conducive to soldering. This method is unacceptable from a reliability, repeatability, and ergonomic standpoint. To combat these issues, a fixture was designed to replace the current method. To do so, a twelve step engineering design process was used to create the fixture that would provide a solution to a multitude of problems, and increase the safety and efficiency of production.« less

Hybrids - Best of both worlds. [liquid and solid propellants mated for safe reliable and low cost launch vehicles

NASA Technical Reports Server (NTRS)

Goldberg, Ben E.; Wiley, Dan R.

1991-01-01

An overview is presented of hybrid rocket propulsion systems whereby combining solids and liquids for launch vehicles could produce a safe, reliable, and low-cost product. The primary subsystems of a hybrid system consist of the oxidizer tank and feed system, an injector system, a solid fuel grain enclosed in a pressure vessel case, a mixing chamber, and a nozzle. The hybrid rocket has an inert grain, which reduces costs of development, transportation, manufacturing, and launch by avoiding many safety measures that must be taken when operating with solids. Other than their use in launch vehicles, hybrids are excellent for simulating the exhaust of solid rocket motors for material development.

The National Aeronautics and Space Administration Nondestructive Evaluation Program for Safe and Reliable Operations

NASA Technical Reports Server (NTRS)

Generazio, Ed

2005-01-01

The National Aeronautics and Space Administration (NASA) Nondestructive Evaluation (NDE) Program is presented. As a result of the loss of seven astronauts and the Space Shuttle Columbia on February 1, 2003, NASA has undergone many changes in its organization. NDE is one of the key areas that are recognized by the Columbia Accident Investigation Board (CAIB) that needed to be strengthened by warranting NDE as a discipline with Independent Technical Authority (iTA). The current NASA NDE system and activities are presented including the latest developments in inspection technologies being applied to the Space Transportation System (STS). The unfolding trends and directions in NDE for the future are discussed as they apply to assuring safe and reliable operations.

Development of a Pebble-Bed Liquid-Nitrogen Evaporator/Superheater for the BRL 1/6th Scale Large Blast/Thermal Simulator Test Bed. Phase 1. Prototype Design and Analysis

DTIC Science & Technology

1991-08-01

specifications are taken primarily from the 1983 version of the ASME Boiler and Pressure Vessel Code . Other design requirements were developea from standard safe...rules and practices of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code to provide a safe and reliable system

Cellular Therapy to Obtain Rapid Endochondral Bone Formation

DTIC Science & Technology

2012-03-01

biological information and involves the development of a novel biomaterial that can safely house the cells expressing the bone inductive factor to... produce the new bone at which time the material is then selectively eliminated. Ultimately this system has significant applicability. Often bone graft must...hypothesis will provide a safe and efficacious material for the production of bone leading to reliable fracture healing, circumventing the need for

Combating the Reliability Challenge of GPU Register File at Low Supply Voltage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, Jingweijia; Song, Shuaiwen; Yan, Kaige

Supply voltage reduction is an effective approach to significantly reduce GPU energy consumption. As the largest on-chip storage structure, the GPU register file becomes the reliability hotspot that prevents further supply voltage reduction below the safe limit (Vmin) due to process variation effects. This work addresses the reliability challenge of the GPU register file at low supply voltages, which is an essential first step for aggressive supply voltage reduction of the entire GPU chip. We propose GR-Guard, an architectural solution that leverages long register dead time to enable reliable operations from unreliable register file at low voltages.

18 CFR 39.8 - Delegation to a Regional Entity.

Code of Federal Regulations, 2010 CFR

2010-04-01

... agreement promotes effective and efficient administration of Bulk-Power System reliability. (d) The... Interconnection-wide basis promotes effective and efficient administration of Bulk-Power System reliability and... THE ELECTRIC RELIABILITY ORGANIZATION; AND PROCEDURES FOR THE ESTABLISHMENT, APPROVAL, AND ENFORCEMENT...

Types and status of high reliability practices in the US federal wildland fire community

Treesearch

Anne E. Black

2012-01-01

Since emerging in the late 1980s, the paradigm of High Reliability Organizing (HRO) has sought to describe how and why certain organizations consistently function safely under hazardous conditions. Researchers have explored a variety of industrial situations, from the early observations of nuclear aircraft carrier operations to nursing units and even high-tech IPOs....

Astronomy Teaching Self-Efficacy Belief Scale: The Validity and Reliability Study

ERIC Educational Resources Information Center

Demirci, Filiz; Ozyurek, Cengiz

2018-01-01

The purpose of this study is to develop a reliable and safe scale for determining the self-efficacy levels of science teachers in the teaching of astronomy subjects. The study used a survey approach, which is a qualitative research method. The study was conducted with a total of 106 science teachers working in the secondary schools of Ordu city…

Overview of NASA Ultracapacitor Technology

NASA Technical Reports Server (NTRS)

Hill, Curtis W.

2017-01-01

NASA needed a lower mass, reliable, and safe medium for energy storage for ground-based and space applications. Existing industry electrochemical systems are limited in weight, charge rate, energy density, reliability, and safety. We chose a ceramic perovskite material for development, due to its high inherent dielectric properties, long history of use in the capacitor industry, and the safety of a solid state material.

Reliability and validity of the Safe Routes to school parent and student surveys

PubMed Central

2011-01-01

Background The purpose of this study is to assess the reliability and validity of the U.S. National Center for Safe Routes to School's in-class student travel tallies and written parent surveys. Over 65,000 tallies and 374,000 parent surveys have been completed, but no published studies have examined their measurement properties. Methods Students and parents from two Charlotte, NC (USA) elementary schools participated. Tallies were conducted on two consecutive days using a hand-raising protocol; on day two students were also asked to recall the previous days' travel. The recall from day two was compared with day one to assess 24-hour test-retest reliability. Convergent validity was assessed by comparing parent-reports of students' travel mode with student-reports of travel mode. Two-week test-retest reliability of the parent survey was assessed by comparing within-parent responses. Reliability and validity were assessed using kappa statistics. Results A total of 542 students participated in the in-class student travel tally reliability assessment and 262 parent-student dyads participated in the validity assessment. Reliability was high for travel to and from school (kappa > 0.8); convergent validity was lower but still high (kappa > 0.75). There were no differences by student grade level. Two-week test-retest reliability of the parent survey (n = 112) ranged from moderate to very high for objective questions on travel mode and travel times (kappa range: 0.62 - 0.97) but was substantially lower for subjective assessments of barriers to walking to school (kappa range: 0.31 - 0.76). Conclusions The student in-class student travel tally exhibited high reliability and validity at all elementary grades. The parent survey had high reliability on questions related to student travel mode, but lower reliability for attitudinal questions identifying barriers to walking to school. Parent survey design should be improved so that responses clearly indicate issues that influence parental decision making in regards to their children's mode of travel to school. PMID:21651794

A Safe and Efficient Technique for the Production of HCl/DCl Gas

ERIC Educational Resources Information Center

Mayer, Steven G.; Bard, Raymond R.; Cantrell, Kevin

2008-01-01

We present a safe and efficient technique to generate HCl/DCl gas for use in the classic physical chemistry experiment that introduces students to ro-vibrational spectroscopy. The reaction involves thionyl chloride and a mixture of water and deuterium oxide to produce HCl/DCl gas with SO[subscript 2] gas as a byproduct. The entire reaction is…

Marine, Tropical, and Tsunami Services

Science.gov Websites

essential to the conduct of safe and efficient maritime operations and for the protection of the marine - Managed by National Data Buoy Center (NDBC) Awareness Weeks: Tsunami Preparedness Campaigns National Safe Prepared and Stay Safe! Tsunami Preparedness: Applying Lessons from the Past Pacific Tsunami Warning Center

An accurate and efficient reliability-based design optimization using the second order reliability method and improved stability transformation method

NASA Astrophysics Data System (ADS)

Meng, Zeng; Yang, Dixiong; Zhou, Huanlin; Yu, Bo

2018-05-01

The first order reliability method has been extensively adopted for reliability-based design optimization (RBDO), but it shows inaccuracy in calculating the failure probability with highly nonlinear performance functions. Thus, the second order reliability method is required to evaluate the reliability accurately. However, its application for RBDO is quite challenge owing to the expensive computational cost incurred by the repeated reliability evaluation and Hessian calculation of probabilistic constraints. In this article, a new improved stability transformation method is proposed to search the most probable point efficiently, and the Hessian matrix is calculated by the symmetric rank-one update. The computational capability of the proposed method is illustrated and compared to the existing RBDO approaches through three mathematical and two engineering examples. The comparison results indicate that the proposed method is very efficient and accurate, providing an alternative tool for RBDO of engineering structures.

MYC and MYCN amplification can be reliably assessed by aCGH in medulloblastoma.

PubMed

Bourdeaut, Franck; Grison, Camille; Maurage, Claude-Alain; Laquerriere, Annie; Vasiljevic, Alexandre; Delisle, Marie-Bernadette; Michalak, Sophie; Figarella-Branger, Dominique; Doz, François; Richer, Wilfrid; Pierron, Gaelle; Miquel, Catherine; Delattre, Olivier; Couturier, Jérôme

2013-04-01

As prognostic factors, MYC and MYCN amplifications are routinely assessed in medulloblastomas. Fluorescence in situ hybridization (FISH) is currently considered as the technique of reference. Recently, array comparative genomic hybridization (aCGH) has been developed as an alternative technique to evaluate genomic abnormalities in other tumor types; however, this technique has not been widely adopted as a replacement for FISH in medulloblastoma. In this study, 34 tumors were screened by both FISH and aCGH. In all cases showing amplification by FISH, aCGH also unambiguously revealed the abnormality. The aCGH technique was also performed on tumors showing no amplification by FISH, and the absence of amplification was confirmed in all cases. Interestingly, one tumor showed a subclonal MYC amplification by FISH. This subclonal amplification was observed in approximately 20% of tumor cells and was clearly evident on aCGH. In conclusion, our analysis confirms that aCGH is as safe as FISH for the detection of MYC/MYCN gene amplification. Given its cost efficiency in comparison to two FISH tests and the global genomic information additionally provided by an aCGH experiment, this reproducible technique can be safely retained as an alternative to FISH for routine investigation of medulloblastoma. Copyright © 2013 Elsevier Inc. All rights reserved.

Development and Testing of a Prototype Grid-Tied Photovoltaic Power System

NASA Technical Reports Server (NTRS)

Eichenberg, Dennis J.

2009-01-01

The NASA Glenn Research Center (GRC) has developed and tested a prototype 2 kW DC grid-tied photovoltaic (PV) power system at the Center. The PV system has generated in excess of 6700 kWh since operation commenced in July 2006. The PV system is providing power to the GRC grid for use by all. Operation of the prototype PV system has been completely trouble free. A grid-tied PV power system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility. The project transfers space technology to terrestrial use via nontraditional partners. GRC personnel glean valuable experience with PV power systems that are directly applicable to various space power systems, and provide valuable space program test data. PV power systems help to reduce harmful emissions and reduce the Nation s dependence on fossil fuels. Power generated by the PV system reduces the GRC utility demand, and the surplus power aids the community. Present global energy concerns reinforce the need for the development of alternative energy systems. Modern PV panels are readily available, reliable, efficient, and economical with a life expectancy of at least 25 years. Modern electronics has been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy of at least 25 years. Based upon the success of the prototype PV system, additional PV power system expansion at GRC is under consideration. The prototype grid-tied PV power system was successfully designed and developed which served to validate the basic principles described, and the theoretical work that was performed. The report concludes that grid-tied photovoltaic power systems are reliable, maintenance free, long life power systems, and are of significant value to NASA and the community.

So What's an RTG and Are They Safe?

NASA Technical Reports Server (NTRS)

Barret, Chris; Hughes, R. W. (Technical Monitor)

2001-01-01

When one considers space missions to the outer edges of our solar system and far beyond, our sun cannot be relied on to produce the required spacecraft (s/c) power. Solar energy diminishes as the square of the distance from the Sun. At Mars it is only 43% of that at earth. At Jupiter, it falls off to only 3.6% of Earth's. By the time we get out to Pluto, solar energy is only .066% what it is on Earth. Beyond the orbit of Mars, it is not practical to depend on solar power for a s/c. However, the farther out we go the more power we need to heat the s/c and to transmit data back to Earth over the long distances. On Earth, knowledge is power. In the outer solar system, power is knowledge. Solar arrays only operate at 19% efficiency, are very vulnerable to damage from radiation and temperature extremes, and cannot be used for even nearby missions that operate in extended darkness, or under the surface of a planet or moon. Twenty-six U.S. space missions, from the Transit to Cassini, have used radioisotope power systems and heater units to take s/c to the far reaches of our solar system and have demonstrated an outstanding record of safety and reliability. Radioisotope thermoelectric generators (RTG's) have proven to be safe, reliable, maintenance-free, and capable of providing both thermal and electrical power for decades under the harsh environments of deep space. RTG's have no problem operating in the high radiation belts of space, the extreme temperatures, or the severe dust storms of Mars, and they have proven to be the most reliable power source ever flown on U.S. s/c. For example, the two Pioneer s/c operated for more than two decades and the Voyager s/c may last for 40 years. RTG's are not nuclear reactors, they serve only as power generators and are not involved in the propulsion of the s/c. They operate on the principle of thermoelectric generation that converts heat directly into electricity, they have no moving parts, are extremely reliable, and have met or exceeded all safety and performance expectations. Federal laws and regulations require analysis and evaluation of the safety risks and any potential environmental impacts. Extensive safety testing of RTG's and RTG components has been performed by the U.S. Department of Energy (DOE) to demonstrate the ability to survive accidents related to Space Shuttle launches and assure that the systems would be safe under all accident conditions, including accidents at or near the launch pad or during orbital reentry. Many design improvements have been made over the four decades that RTG's have been flown on space missions. This paper outlines the operation and safety standards of RTG's and the advanced developments expected to be used on future deep space missions such as the Europa Orbiter, Pluto/Kuiper Express, Solar Probe, Europa Lander, and Titan Explorer missions.

7 CFR 1924.107 - Utilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... under this subpart must have adequate, economic, safe, energy efficient, dependable utilities with... wastewater systems are in compliance with the current provisions of the Safe Drinking Water Act and the Clean...

7 CFR 1924.107 - Utilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... under this subpart must have adequate, economic, safe, energy efficient, dependable utilities with... wastewater systems are in compliance with the current provisions of the Safe Drinking Water Act and the Clean...

7 CFR 1924.107 - Utilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... under this subpart must have adequate, economic, safe, energy efficient, dependable utilities with... wastewater systems are in compliance with the current provisions of the Safe Drinking Water Act and the Clean...

7 CFR 1924.107 - Utilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... under this subpart must have adequate, economic, safe, energy efficient, dependable utilities with... wastewater systems are in compliance with the current provisions of the Safe Drinking Water Act and the Clean...

7 CFR 1924.107 - Utilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... under this subpart must have adequate, economic, safe, energy efficient, dependable utilities with... wastewater systems are in compliance with the current provisions of the Safe Drinking Water Act and the Clean...

Analysis of Time Dependent Electric Field Degradation in AlGaN/GaN HEMTs (POSTPRINT)

DTIC Science & Technology

2014-10-01

identifying and understanding the failure mechanisms that limit the safe operating area of GaN HEMTs. 15. SUBJECT TERMS aluminum gallium nitride... gallium nitride, HEMTs, semiconductor device reliability, transistors 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER...area of GaN HEMTs. Index Terms— Aluminum gallium nitride, gallium nitride, HEMTs, semiconductor device reliability, transistors. I. INTRODUCTION A

Non-linear dynamic characteristics and optimal control of giant magnetostrictive film subjected to in-plane stochastic excitation

NASA Astrophysics Data System (ADS)

Zhu, Z. W.; Zhang, W. D.; Xu, J.

2014-03-01

The non-linear dynamic characteristics and optimal control of a giant magnetostrictive film (GMF) subjected to in-plane stochastic excitation were studied. Non-linear differential items were introduced to interpret the hysteretic phenomena of the GMF, and the non-linear dynamic model of the GMF subjected to in-plane stochastic excitation was developed. The stochastic stability was analysed, and the probability density function was obtained. The condition of stochastic Hopf bifurcation and noise-induced chaotic response were determined, and the fractal boundary of the system's safe basin was provided. The reliability function was solved from the backward Kolmogorov equation, and an optimal control strategy was proposed in the stochastic dynamic programming method. Numerical simulation shows that the system stability varies with the parameters, and stochastic Hopf bifurcation and chaos appear in the process; the area of the safe basin decreases when the noise intensifies, and the boundary of the safe basin becomes fractal; the system reliability improved through stochastic optimal control. Finally, the theoretical and numerical results were proved by experiments. The results are helpful in the engineering applications of GMF.

Software service history report

DOT National Transportation Integrated Search

2002-01-01

The safe and reliable operation of software within civil aviation systems and equipment has historically been assured through the application of rigorous design assurance applied during the software development process. Increasingly, manufacturers ar...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, J.

The Department of Energy of the United States of America works to guarantee provisions of safe energy, reliable and economically accessible to support to one developing economy and to protect the atmosphere. These suggestions and ideas to increase the energy efficiency in their house represent simple ways in which our citizens can contribute to preserve the atmosphere at world-wide level, to reduce the level of contamination of the air and to reserve our natural resources for future generations. [Spanish] El Departamento de Energa de los Estados Unidos de America trabaja para garantizar suministros de energa seguros, confiables y econmicamente accesiblesmore » para apoyar a una economa en desarrollo y proteger el medio ambiente. Estas sugerencias e ideas para aumentar la eficiencia energetica en su casa representan maneras sencillas en que nuestros ciudadanos pueden contribuir a preservar el medio ambiente a nivel mundial, a reducir el nivel de contaminacin del aire y a reservar nuestros recursos naturales para las generaciones futuras.« less

Science and technology in the stockpile stewardship program, S & TR reprints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Storm, E

This document reports on these topics: Computer Simulations in Support of National Security; Enhanced Surveillance of Aging Weapons; A New Precision Cutting Tool: The Femtosecond Laser; Superlasers as a Tool of Stockpile Stewardship; Nova Laser Experiments and Stockpile Stewardship; Transforming Explosive Art into Science; Better Flash Radiography Using the FXR; Preserving Nuclear Weapons Information; Site 300Õs New Contained Firing Facility; The Linear Electric Motor: Instability at 1,000 gÕs; A Powerful New Tool to Detect Clandestine Nuclear Tests; High Explosives in Stockpile Surveillance Indicate Constancy; Addressing a Cold War Legacy with a New Way to Produce TATB; JumpinÕ Jupiter! Metallic Hydrogen;more » Keeping the Nuclear Stockpile Safe, Secure, and Reliable; The Multibeam FabryÐPerot Velocimeter: Efficient Measurements of High Velocities; Theory and Modeling in Material Science; The Diamond Anvil Cell; Gamma-Ray Imaging Spectrometry; X-Ray Lasers and High-Density Plasma« less

Safe and Efficient Support for Embeded Multi-Processors in ADA

NASA Astrophysics Data System (ADS)

Ruiz, Jose F.

2010-08-01

New software demands increasing processing power, and multi-processor platforms are spreading as the answer to achieve the required performance. Embedded real-time systems are also subject to this trend, but in the case of real-time mission-critical systems, the properties of reliability, predictability and analyzability are also paramount. The Ada 2005 language defined a subset of its tasking model, the Ravenscar profile, that provides the basis for the implementation of deterministic and time analyzable applications on top of a streamlined run-time system. This Ravenscar tasking profile, originally designed for single processors, has proven remarkably useful for modelling verifiable real-time single-processor systems. This paper proposes a simple extension to the Ravenscar profile to support multi-processor systems using a fully partitioned approach. The implementation of this scheme is simple, and it can be used to develop applications amenable to schedulability analysis.

Detection of Cardiopulmonary Activity and Related Abnormal Events Using Microsoft Kinect Sensor.

PubMed

Al-Naji, Ali; Chahl, Javaan

2018-03-20

Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not. The proposed system extracts the signal from the abdominal-thoracic region where cardiopulmonary activity is most pronounced, using a real-time image sequence captured by Kinect v2 sensor. The proposed system shows promising results in any sleep posture, regardless of illumination conditions and unclear ROI even in the presence of a blanket, whilst being reliable, safe, and cost-effective.

Detection of Cardiopulmonary Activity and Related Abnormal Events Using Microsoft Kinect Sensor

PubMed Central

Chahl, Javaan

2018-01-01

Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not. The proposed system extracts the signal from the abdominal-thoracic region where cardiopulmonary activity is most pronounced, using a real-time image sequence captured by Kinect v2 sensor. The proposed system shows promising results in any sleep posture, regardless of illumination conditions and unclear ROI even in the presence of a blanket, whilst being reliable, safe, and cost-effective. PMID:29558414

Study of the technics of coating stripping and FBG writing on polyimide fiber

NASA Astrophysics Data System (ADS)

Song, ZhiQiang; Qi, HaiFeng; Ni, JiaSheng; Wang, Chang

2017-10-01

Compared with ordinary optical fiber, polyimide fiber has the characteristics of high temperature resistance and high strength, which has important application in the field of optical fiber sensing. The common methods of polyimide coating stripping were introduced in this paper, including high temperature stripping, chemical stripping and arc ablation. In order to meet the requirements of FBG writing technology, a method using argon ion laser ablation coating was proposed. The method can precisely control the stripping length of the coating and completely does not affect the tensile strength of the optical fiber. According to the experiment, the fabrication process of polyimide FBG is stripping-hydrogen loadingwriting. Under the same conditions, 10 FBG samples were fabricated with good uniformity of wavelength bandwidth and reflectivity. UV laser ablation of polyimide coating has been proved to be a safe, reliable and efficient method.

[Monitoring evaluation system for high-specialty hospitals].

PubMed

Fajardo Dolci, Germán; Aguirre Gas, Héctor G; Robledo Galván, Héctor

2011-01-01

Hospital evaluation is a fundamental process to identify medical units' objective compliance, to analyze efficiency of resource use and allocation, institutional values and mission alignment, patient safety and quality standards, contributions to research and medical education, and the degree of coordination among medical units and the health system as a whole. We propose an evaluation system for highly specialized regional hospitals through the monitoring of performance indicators. The following are established as base thematic elements in the construction of indicators: safe facilities and equipment, financial situation, human resources management, policy management, organizational climate, clinical activity, quality and patient safety, continuity of care, patients' and providers' rights and obligations, teaching, research, social responsibility, coordination mechanisms. Monitoring refers to the planned and systematic evaluation of valid and reliable indicators, aimed at identifying problems and opportunity areas. Moreover, evaluation is a powerful tool to strengthen decision-making and accountability in medical units.

Laser restorative dentistry in children and adolescents.

PubMed

Olivi, G; Genovese, M D

2011-04-01

The idea of substituting a drill with a laser light, has led to its introduction in dentistry. Besides being more accepted to patients, in paediatric dentistry the laser has demonstrated safety compared with rotating instruments. A review of the past 20 years of the dental literature concerning laser use in dentistry, including paediatric dentistry was completed. The findings of that review are presented. The various types of lasers and their uses for caries detection, tooth sealing and caries removal are described. Laser caries detection demonstrated a good reproducibility, reliability and predictability to monitor the caries process over time. Erbium lasers have been found to be efficient for caries removal, tooth cleaning and decontamination. The laser erbium technology represents a safe device to effectively and selectively remove carious tissues from decayed teeth. For children, all the recognized advantages of this technique play a decisive role in the successful day-to-day treatment of dental caries.

Future Opportunities and Challenges with Using Demand Response as a Resource in Distribution System Operation and Planning Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cappers, Peter; MacDonald, Jason; Page, Janie

2016-01-01

This scoping study focuses on identifying the ability for current and future demand response opportunities to contribute to distribution system management. To do so, this scoping study will identify the needs of a distribution system to operate efficiently, safely and reliably; summarize both benefits and challenges for the operation of the distribution system with high penetration levels of distributed energy resources; define a suite of services based on those changing operational needs that could be provided by resources; identify existing demand response opportunities sponsored by distribution utilities and/or aggregators of retail customers; assess the extent to which distribution system servicesmore » can be provided via DR opportunities both in their current form and with alterations to their design; and provide a qualitative assessment of coordination issues that bulk power and distribution system providers of DR opportunities will need to address.« less

Implementing a resource management program for accreditation process at the medical laboratory.

PubMed

Yenice, Sedef

2009-03-01

To plan for and provide adequate resources to meet the mission and goals of a medical laboratory in compliance with the requirements for laboratory accreditation by Joint Commission International. The related policies and procedures were developed based on standard requirements for resource management. Competency assessment provided continuing education and performance feedback to laboratory employees. Laboratory areas were designed for the efficient and safe performance of laboratory work. A physical environment was built up where hazards were controlled and personnel activities were managed to reduce the risk of injuries. An Employees Occupational Safety and Health Program (EOSHP) was developed to address all types of hazardous materials and wastes. Guidelines were defined to verify that the methods would produce accurate and reliable results. An active resource management program will be an effective way of assuring that systems are in control and continuous improvement is in progress.

Design considerations for eye-safe single-aperture laser radars

NASA Astrophysics Data System (ADS)

Starodubov, D.; McCormick, K.; Volfson, L.

2015-05-01

The design considerations for low cost, shock resistant, compact and efficient laser radars and ranging systems are discussed. The reviewed approach with single optical aperture allows reducing the size, weight and power of the system. Additional design benefits include improved stability, reliability and rigidity of the overall system. The proposed modular architecture provides simplified way of varying the performance parameters of the range finder product family by selecting the sets of specific illumination and detection modules. The performance operation challenges are presented. The implementation of non-reciprocal optical elements is considered. The cross talk between illumination and detection channels for single aperture design is reviewed. 3D imaging capability for the ranging applications is considered. The simplified assembly and testing process for single aperture range finders that allows to mass produce the design are discussed. The eye safety of the range finder operation is summarized.

A criterion for establishing life limits. [for Space Shuttle Main Engine service

NASA Technical Reports Server (NTRS)

Skopp, G. H.; Porter, A. A.

1990-01-01

The development of a rigorous statistical method that would utilize hardware-demonstrated reliability to evaluate hardware capability and provide ground rules for safe flight margin is discussed. A statistical-based method using the Weibull/Weibayes cumulative distribution function is described. Its advantages and inadequacies are pointed out. Another, more advanced procedure, Single Flight Reliability (SFR), determines a life limit which ensures that the reliability of any single flight is never less than a stipulated value at a stipulated confidence level. Application of the SFR method is illustrated.

40 CFR 35.3500 - Purpose, policy, and applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Revolving Fund program under section 1452 of the Safe Drinking Water Act, as amended in 1996. It applies to... health protection objectives of the Safe Drinking Water Act, promote the efficient use of all funds, and... systems. (b) This subpart supplements section 1452 of the Safe Drinking Water Act by codifying statutory...

40 CFR 35.3500 - Purpose, policy, and applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Revolving Fund program under section 1452 of the Safe Drinking Water Act, as amended in 1996. It applies to... health protection objectives of the Safe Drinking Water Act, promote the efficient use of all funds, and... systems. (b) This subpart supplements section 1452 of the Safe Drinking Water Act by codifying statutory...

45 CFR 1310.17 - Driver and bus monitor training.

Code of Federal Regulations, 2010 CFR

2010-10-01

... safe and efficient manner; (2) safely run a fixed route, including loading and unloading children... first aid in case of injury; (4) handle emergency situations, including vehicle evacuation procedures...

Infrastructure-Based Sensors Augmenting Efficient Autonomous Vehicle Operations: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jun, Myungsoo; Markel, Anthony J

Autonomous vehicle technology development relies on an on-board network of fused sensor inputs for safe and efficient operation. The fused sensors offer multiple perspectives of similar information aiding in system decision robustness. The high cost of full systems on individual vehicles is seen as a potential barrier to broad adoption and achieving system energy efficiency gains. Since traffic in autonomous vehicle technology development relies on an on-board network of fused sensor inputs for safe and efficient operation. The fused sensors offer multiple perspectives of similar information aiding in system decision robustness. The high cost of full systems on individual vehiclesmore » is seen as a potential barrier to broad adoption and achieving system energy efficiency gains.« less

Reliability-based trajectory optimization using nonintrusive polynomial chaos for Mars entry mission

NASA Astrophysics Data System (ADS)

Huang, Yuechen; Li, Haiyang

2018-06-01

This paper presents the reliability-based sequential optimization (RBSO) method to settle the trajectory optimization problem with parametric uncertainties in entry dynamics for Mars entry mission. First, the deterministic entry trajectory optimization model is reviewed, and then the reliability-based optimization model is formulated. In addition, the modified sequential optimization method, in which the nonintrusive polynomial chaos expansion (PCE) method and the most probable point (MPP) searching method are employed, is proposed to solve the reliability-based optimization problem efficiently. The nonintrusive PCE method contributes to the transformation between the stochastic optimization (SO) and the deterministic optimization (DO) and to the approximation of trajectory solution efficiently. The MPP method, which is used for assessing the reliability of constraints satisfaction only up to the necessary level, is employed to further improve the computational efficiency. The cycle including SO, reliability assessment and constraints update is repeated in the RBSO until the reliability requirements of constraints satisfaction are satisfied. Finally, the RBSO is compared with the traditional DO and the traditional sequential optimization based on Monte Carlo (MC) simulation in a specific Mars entry mission to demonstrate the effectiveness and the efficiency of the proposed method.

Transit emergency planning guidance.

DOT National Transportation Integrated Search

2007-07-01

Providing safe, reliable transportation has long been a priority at all levels of : the transit industry including the Federal Transit Administration (FTA), : state Departments of Transportation and individual transit providers. Over the : last decad...

Safe and efficient use of the Internet.

PubMed

Downes, P K

2007-07-14

A minority of people abuse the freedom of the Internet to the detriment of the vast majority. Many people feel that the Internet requires more regulation to reduce the burden of hackers, viruses, hoaxes, adverts and spam that continue to proliferate unabated. Until this ever happens, it is down to the individual person or business to protect themselves against malicious attacks and to use the Internet in a safe and efficient manner.

The Sustainable Nuclear Future: Fission and Fusion E.M. Campbell Logos Technologies

NASA Astrophysics Data System (ADS)

Campbell, E. Michael

2010-02-01

Global industrialization, the concern over rising CO2 levels in the atmosphere and other negative environmental effects due to the burning of hydrocarbon fuels and the need to insulate the cost of energy from fuel price volatility have led to a renewed interest in nuclear power. Many of the plants under construction are similar to the existing light water reactors but incorporate modern engineering and enhanced safety features. These reactors, while mature, safe and reliable sources of electrical power have limited efficiency in converting fission power to useful work, require significant amounts of water, and must deal with the issues of nuclear waste (spent fuel), safety, and weapons proliferation. If nuclear power is to sustain its present share of the world's growing energy needs let alone displace carbon based fuels, more than 1000 reactors will be needed by mid century. For this to occur new reactors that are more efficient, versatile in their energy markets, require minimal or no water, produce less waste and more robust waste forms, are inherently safe and minimize proliferation concerns will be necessary. Graphite moderated, ceramic coated fuel, and He cooled designs are reactors that can satisfy these requirements. Along with other generation IV fast reactors that can further reduce the amounts of spent fuel and extend fuel resources, such a nuclear expansion is possible. Furthermore, facilities either in early operations or under construction should demonstrate the next step in fusion energy development in which energy gain is produced. This demonstration will catalyze fusion energy development and lead to the ultimate development of the next generation of nuclear reactors. In this presentation the role of advanced fission reactors and future fusion reactors in the expansion of nuclear power will be discussed including synergies with the existing worldwide nuclear fleet. )

Rural transit emergency planning guidance.

DOT National Transportation Integrated Search

2008-07-01

Providing safe, reliable transportation has long been a priority at all levels of the transit industry including the Federal Transit Administration (FTA), California Department of Transportation (Caltrans) and individual transit providers. Over the l...

Benchmarking Heavy Ion Transport Codes FLUKA, HETC-HEDS MARS15, MCNPX, and PHITS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ronningen, Reginald Martin; Remec, Igor; Heilbronn, Lawrence H.

Powerful accelerators such as spallation neutron sources, muon-collider/neutrino facilities, and rare isotope beam facilities must be designed with the consideration that they handle the beam power reliably and safely, and they must be optimized to yield maximum performance relative to their design requirements. The simulation codes used for design purposes must produce reliable results. If not, component and facility designs can become costly, have limited lifetime and usefulness, and could even be unsafe. The objective of this proposal is to assess the performance of the currently available codes PHITS, FLUKA, MARS15, MCNPX, and HETC-HEDS that could be used for designmore » simulations involving heavy ion transport. We plan to access their performance by performing simulations and comparing results against experimental data of benchmark quality. Quantitative knowledge of the biases and the uncertainties of the simulations is essential as this potentially impacts the safe, reliable and cost effective design of any future radioactive ion beam facility. Further benchmarking of heavy-ion transport codes was one of the actions recommended in the Report of the 2003 RIA R&D Workshop".« less

Safe Direct Current Stimulator design for reduced power consumption and increased reliability.

PubMed

Fridman, Gene

2017-07-01

Current state of the art neural prosthetics, such as cochlear implants, spinal cord stimulators, and deep brain stimulators use implantable pulse generators (IPGs) to excite neural activity. Inhibition of neural firing is typically indirect and requires excitation of neurons that then have inhibitory projections downstream. Safe Direct Current Stimulator (SDCS) technology is designed to convert electronic pulses delivered to electrodes embedded within an implantable device to ionic direct current (iDC) at the output of the device. iDC from the device can then control neural extracellular potential with the intent of being able to not only excite, but also inhibit and sensitize neurons, thereby greatly expanding the possible applications of neuromodulation therapies and neural interface mechanisms. While the potential applications and proof of concept of this device have been the focus of previous work, the published descriptions of this technology leave significant room for power and reliability optimization. We describe and model a novel device construction designed to reduce power consumption by a factor of 12 and to improve its reliability by a factor of 8.

The Role of Probabilistic Design Analysis Methods in Safety and Affordability

NASA Technical Reports Server (NTRS)

Safie, Fayssal M.

2016-01-01

For the last several years, NASA and its contractors have been working together to build space launch systems to commercialize space. Developing commercial affordable and safe launch systems becomes very important and requires a paradigm shift. This paradigm shift enforces the need for an integrated systems engineering environment where cost, safety, reliability, and performance need to be considered to optimize the launch system design. In such an environment, rule based and deterministic engineering design practices alone may not be sufficient to optimize margins and fault tolerance to reduce cost. As a result, introduction of Probabilistic Design Analysis (PDA) methods to support the current deterministic engineering design practices becomes a necessity to reduce cost without compromising reliability and safety. This paper discusses the importance of PDA methods in NASA's new commercial environment, their applications, and the key role they can play in designing reliable, safe, and affordable launch systems. More specifically, this paper discusses: 1) The involvement of NASA in PDA 2) Why PDA is needed 3) A PDA model structure 4) A PDA example application 5) PDA link to safety and affordability.

Reliability Analysis of RSG-GAS Primary Cooling System to Support Aging Management Program

NASA Astrophysics Data System (ADS)

Deswandri; Subekti, M.; Sunaryo, Geni Rina

2018-02-01

Multipurpose Research Reactor G.A. Siwabessy (RSG-GAS) which has been operating since 1987 is one of the main facilities on supporting research, development and application of nuclear energy programs in BATAN. Until now, the RSG-GAS research reactor has been successfully operated safely and securely. However, because it has been operating for nearly 30 years, the structures, systems and components (SSCs) from the reactor would have started experiencing an aging phase. The process of aging certainly causes a decrease in reliability and safe performances of the reactor, therefore the aging management program is needed to resolve the issues. One of the programs in the aging management is to evaluate the safety and reliability of the system and also screening the critical components to be managed.One method that can be used for such purposes is the Fault Tree Analysis (FTA). In this papers FTA method is used to screening the critical components in the RSG-GAS Primary Cooling System. The evaluation results showed that the primary isolation valves are the basic events which are dominant against the system failure.

Development of a reliable estimation procedure of radioactivity inventory in a BWR plant due to neutron irradiation for decommissioning

NASA Astrophysics Data System (ADS)

Tanaka, Ken-ichi; Ueno, Jun

2017-09-01

Reliable information of radioactivity inventory resulted from the radiological characterization is important in order to plan decommissioning planning and is also crucial in order to promote decommissioning in effectiveness and in safe. The information is referred to by planning of decommissioning strategy and by an application to regulator. Reliable information of radioactivity inventory can be used to optimize the decommissioning processes. In order to perform the radiological characterization reliably, we improved a procedure of an evaluation of neutron-activated materials for a Boiling Water Reactor (BWR). Neutron-activated materials are calculated with calculation codes and their validity should be verified with measurements. The evaluation of neutron-activated materials can be divided into two processes. One is a distribution calculation of neutron-flux. Another is an activation calculation of materials. The distribution calculation of neutron-flux is performed with neutron transport calculation codes with appropriate cross section library to simulate neutron transport phenomena well. Using the distribution of neutron-flux, we perform distribution calculations of radioactivity concentration. We also estimate a time dependent distribution of radioactivity classification and a radioactive-waste classification. The information obtained from the evaluation is utilized by other tasks in the preparatory tasks to make the decommissioning plan and the activity safe and rational.

Preservation of live cultures of basidiomycetes - recent methods.

PubMed

Homolka, Ladislav

2014-02-01

Basidiomycetes are used in industrial processes, in basic or applied research, teaching, systematic and biodiversity studies. Efficient work with basidiomycete cultures requires their reliable source, which is ensured by their safe long-term storage. Repeated subculturing, frequently used for the preservation, is time-consuming, prone to contamination, and does not prevent genetic and physiological changes during long-term maintenance. Various storage methods have been developed in order to eliminate these disadvantages. Besides lyophilization (unsuitable for the majority of basidiomycetes), cryopreservation at low temperatures seems to be a very efficient way to attain this goal. Besides survival, another requirement for successful maintenance of fungal strains is the ability to preserve their features unchanged. An ideal method has not been created so far. Therefore it is highly desirable to develop new or improve the current preservation methods, combining advantages and eliminate disadvantages of individual techniques. Many reviews on preservation of microorganisms including basidiomycetes have been published, but the progress in the field requires an update. Although herbaria specimens of fungi (and of basidiomycetes in particular) are very important for taxonomic and especially typological studies, this review is limited to live fungal cultures. Copyright © 2013 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

Biodegradable fixation of mandibular fractures in children: stability and early results.

PubMed

Yerit, Kaan C; Hainich, Sibylle; Enislidis, Georg; Turhani, Dritan; Klug, Clemens; Wittwer, Gert; Ockher, Michael; Undt, Gerhard; Kermer, Christian; Watzinger, Franz; Ewers, Rolf

2005-07-01

The aim of this study was to assess the safety and efficiency of biodegradable self-reinforced (SR-PLDLA) bone plates and screws in open reduction and internal fixation of mandible fractures in children. Thirteen patients (5 female, 8 male; mean age 12 years, range 5-16 years) were operated on various fractures of the mandible (2 symphyseal, 6 parasymphyseal, 4 body, 3 angle, 1 ramus, 2 condylar fractures). The mean follow-up time was 26.4 months (range 10.9-43.4 months). Intermaxillary fixation was applied in cases with concomitant condylar fractures up to 3 weeks. Primary healing of the fractured mandible was observed in all patients. Postoperative complications were minor and transient. The outcome of the operations was not endangered. Adverse tissue reactions to the implants, malocclusion, and growth restrictions did not occur during the observation period. Pediatric patients benefit from the advantages of resorbable materials, especially from faster mobilization and the avoidance of secondary removal operations. Based on these preliminary results, self-reinforced fixation devices are safe and efficient in the treatment of pediatric mandible fractures. However, further clinical investigations are necessary to evaluate the long-term reliability.

Automating a spacecraft electrical power system using expert systems

NASA Technical Reports Server (NTRS)

Lollar, L. F.

1991-01-01

Since Skylab, Marshall Space Flight Center (MSFC) has recognized the need for large electrical power systems (EPS's) in upcoming Spacecraft. The operation of the spacecraft depends on the EPS. Therefore, it must be efficient, safe, and reliable. In 1978, as a consequence of having to supply a large number of EPS personnel to monitor and control Skylab, the Electrical power Branch of MSFC began the autonomously managed power system (AMPS) project. This project resulted in the assembly of a 25-kW high-voltage dc test facility and provided the means of getting man out of the loop as much as possible. AMPS includes several embedded controllers which allow a significant level of autonomous operation. More recently, the Electrical Division at MSFC has developed the space station module power management and distribution (SSM/PMAD) breadboard to investigate managing and distributing power in the Space Station Freedom habitation and laboratory modules. Again, the requirement for a high level of autonomy for the efficient operation over the lifetime of the station and for the benefits of enhanced safety has been demonstrated. This paper describes the two breadboards and the hierarchical approach to automation which was developed through these projects.

Nurses' Attitudes Regarding the Safe Handling of Patients Who Are Morbidly Obese: Instrument Development and Psychometric Analysis.

PubMed

Bejciy-Spring, Susan; Vermillion, Brenda; Morgan, Sally; Newton, Cheryl; Chucta, Sheila; Gatens, Cindy; Zadvinskis, Inga; Holloman, Christopher; Chipps, Esther

2016-12-01

Nurses' attitudes play an important role in the consistent practice of safe patient handling behaviors. The purposes of this study were to develop and assess the psychometric properties of a newly developed instrument measuring attitudes of nurses related to the care and safe handling of patients who are obese. Phases of instrument development included (a) item generation, (b) content validity assessment, (c) reliability assessment, (d) cognitive interviewing, and (e) construct validity assessment through factor analysis. The final data from the exploratory factor analysis produced a 26-item multidimensional instrument that contains 9 subscales. Based on the factor analysis, a 26-item instrument can be used to examine nurses' attitudes regarding patients who are morbidly obese and related safe handling practices.

Small Drinking Water System Initiative | Drinking Water in New ...

EPA Pesticide Factsheets

2017-07-06

Reliable, safe, high quality drinking water is essential to sustaining our communities. Approximately 90% of New England's drinking water systems - about 10,000 systems - are small and most use ground water sources.

SAFE (strategy, assessment, flexibility, and efficiency) for future use? Stages in master planning, programming, and architectural design.

PubMed

Westlake, P

1995-10-01

Health care facility design must incorporate four key elements: Strategy, Assessment, Flexibility, and Efficiency. These SAFE elements will offer the organization the greatest return on investment, because they encompass both present needs and future demand. They respect the integrated nature of functional operations by clustering them in ways that permit growth or consolidation. In the rapidly changing health care environment, flexibility is fundamental to successful design.

Efficient Storing Energy Harvested by Triboelectric Nanogenerators Using a Safe and Durable All-Solid-State Sodium-Ion Battery.

PubMed

Hou, Huidan; Xu, Qingkai; Pang, Yaokun; Li, Lei; Wang, Jiulin; Zhang, Chi; Sun, Chunwen

2017-08-01

Storing energy harvested by triboelectric nanogenerators (TENGs) from ambient mechanical motion is still a great challenge for achieving low-cost and environmental benign power sources. Here, an all-solid-state Na-ion battery with safe and durable performance used for efficient storing pulsed energy harvested by the TENG is demonstrated. The solid-state sodium-ion batteries are charged by galvanostatic mode and pulse mode with the TENG, respectively. The all-solid-state sodium-ion battery displays excellent cyclic performance up to 1000 cycles with a capacity retention of about 85% even at a high charge and discharge current density of 48 mA g -1 . When charged by the TENG, an energy conversion efficiency of 62.3% is demonstrated. The integration of TENGs with the safe and durable all-solid-state sodium-ion batteries is potential for providing more stable power output for self-powered systems.

Assessment of owner-directed aggressive behavioural tendencies of dogs in situations of possession and manipulation.

PubMed

Bálint, Anna; Rieger, Gabriella; Miklósi, Ádám; Pongrácz, Péter

2017-10-01

Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually different behavioural tests: 'take away bone' and 'roll over'. Based on dogs' behaviour in the tests, we sorted dogs ( N  = 93) in two groups for each test, namely a less and a more disobedient/resistant group. The two principal components obtained in our questionnaire-'obedient' and 'aggressive towards owner'-showed significant differences between the behaviour groups. While dogs in the less disobedient/resistant groups had significantly higher 'obedient' and significantly lower 'aggressive towards owner' scores, dogs in the more disobedient/resistant groups had significantly higher 'aggressive towards owner' and significantly lower 'obedient' scores. Dogs' age, sex and neuter/spay status expressed their effect through interactions. Males, young dogs and intact dogs were less 'obedient' than older ones, while resistant spayed/neutered dogs were more aggressive towards the owner. The questionnaire used is a safe, easy to deploy and time-efficient tool to reliably assess certain owner-directed aggressive tendencies of family dogs.

Electronics for Low Temperature Space Exploration Missions

NASA Technical Reports Server (NTRS)

Patterson, Richard L.; Hammoud, Ahmad; Elbuluk, Malik

2007-01-01

Exploration missions to outer planets and deep space require spacecraft, probes, and on-board data and communication systems to operate reliably and efficiently under severe harsh conditions. On-board electronics, in particular those in direct exposures to the space environment without any shielding or protection, will encounter extreme low temperature and thermal cycling in their service cycle in most of NASA s upcoming exploration missions. For example, Venus atmosphere, Jupiter atmosphere, Moon surface, Pluto orbiter, Mars, comets, Titan, Europa, and James Webb Space Telescope all involve low-temperature surroundings. Therefore, electronics for space exploration missions need to be designed for operation under such environmental conditions. There are ongoing efforts at the NASA Glenn Research Center (GRC) to establish a database on the operation and reliability of electronic devices and circuits under extreme temperature operation for space applications. This work is being performed under the Extreme Temperature Electronics Program with collaboration and support of the NASA Electronic Parts and Packaging (NEPP) Program. The results of these investigations will be used to establish safe operating areas and to identify degradation and failure modes, and the information will be disseminated to mission planners and system designers for use as tools for proper part selection and in risk mitigation. An overview of this program along with experimental data will be presented.

Integrated Atmosphere Resource Recovery and Environmental Monitoring Technology Demonstration for Deep Space Exploration

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Abney, Morgan B.; Knox, James C.; Parrish, Keith J.; Roman, Monserrate C.; Jan, Darrell L.

2012-01-01

Exploring the frontiers of deep space continues to be defined by the technological challenges presented by safely transporting a crew to and from destinations of scientific interest. Living and working on that frontier requires highly reliable and efficient life support systems that employ robust, proven process technologies. The International Space Station (ISS), including its environmental control and life support (ECLS) system, is the platform from which humanity's deep space exploration missions begin. The ISS ECLS system Atmosphere Revitalization (AR) subsystem and environmental monitoring (EM) technical architecture aboard the ISS is evaluated as the starting basis for a developmental effort being conducted by the National Aeronautics and Space Administration (NASA) via the Advanced Exploration Systems (AES) Atmosphere Resource Recovery and Environmental Monitoring (ARREM) Project.. An evolutionary approach is employed by the ARREM project to address the strengths and weaknesses of the ISS AR subsystem and EM equipment, core technologies, and operational approaches to reduce developmental risk, improve functional reliability, and lower lifecycle costs of an ISS-derived subsystem architecture suitable for use for crewed deep space exploration missions. The most promising technical approaches to an ISS-derived subsystem design architecture that incorporates promising core process technology upgrades will be matured through a series of integrated tests and architectural trade studies encompassing expected exploration mission requirements and constraints.

Development of ultracapacitor modules for 42-V automotive electrical systems

NASA Astrophysics Data System (ADS)

Jung, Do Yang; Kim, Young Ho; Kim, Sun Wook; Lee, Suck-Hyun

Two types of ultracapacitor modules have been developed for use as energy-storage devices for 42-V systems in automobiles. The modules show high performance and good reliability in terms of discharge and recharge capability, long-term endurance, and high energy and power. During a 42-V system simulation test of 6-kW power boosting/regenerative braking, the modules demonstrate very good performance. In high-power applications such as 42-V and hybrid vehicle systems, ultracapacitors have many merits compared with batteries, especially with respect to specific power at high rate, thermal stability, charge-discharge efficiency, and cycle-life. Ultracapacitors are also very safe, reliable and environmentally friendly. The cost of ultracapacitors is still high compared with batteries because of the low production scale, but is decreasing very rapidly. It is estimated that the cost of ultracapacitors will decrease to US$ 300 per 42-V module in the near future. Also, the maintenance cost of the ultracapacitor is nearly zero because of its high cycle-life. Therefore, the combined cost of the capacitor and maintenance will be lower than that of batteries in the near future. Overall, comparing performance, price and other parameters of ultracapacitors with batteries, ultracapacitors are the most likely candidate for energy-storage in 42-V systems.

Reliability and validity of the Safe Routes to school parent and student surveys.

PubMed

McDonald, Noreen C; Dwelley, Amanda E; Combs, Tabitha S; Evenson, Kelly R; Winters, Richard H

2011-06-08

The purpose of this study is to assess the reliability and validity of the U.S. National Center for Safe Routes to School's in-class student travel tallies and written parent surveys. Over 65,000 tallies and 374,000 parent surveys have been completed, but no published studies have examined their measurement properties. Students and parents from two Charlotte, NC (USA) elementary schools participated. Tallies were conducted on two consecutive days using a hand-raising protocol; on day two students were also asked to recall the previous days' travel. The recall from day two was compared with day one to assess 24-hour test-retest reliability. Convergent validity was assessed by comparing parent-reports of students' travel mode with student-reports of travel mode. Two-week test-retest reliability of the parent survey was assessed by comparing within-parent responses. Reliability and validity were assessed using kappa statistics. A total of 542 students participated in the in-class student travel tally reliability assessment and 262 parent-student dyads participated in the validity assessment. Reliability was high for travel to and from school (kappa > 0.8); convergent validity was lower but still high (kappa > 0.75). There were no differences by student grade level. Two-week test-retest reliability of the parent survey (n=112) ranged from moderate to very high for objective questions on travel mode and travel times (kappa range: 0.62-0.97) but was substantially lower for subjective assessments of barriers to walking to school (kappa range: 0.31-0.76). The student in-class student travel tally exhibited high reliability and validity at all elementary grades. The parent survey had high reliability on questions related to student travel mode, but lower reliability for attitudinal questions identifying barriers to walking to school. Parent survey design should be improved so that responses clearly indicate issues that influence parental decision making in regards to their children's mode of travel to school. © 2011 McDonald et al; licensee BioMed Central Ltd.

Online Monitoring System of Air Distribution in Pulverized Coal-Fired Boiler Based on Numerical Modeling

NASA Astrophysics Data System (ADS)

Żymełka, Piotr; Nabagło, Daniel; Janda, Tomasz; Madejski, Paweł

2017-12-01

Balanced distribution of air in coal-fired boiler is one of the most important factors in the combustion process and is strongly connected to the overall system efficiency. Reliable and continuous information about combustion airflow and fuel rate is essential for achieving optimal stoichiometric ratio as well as efficient and safe operation of a boiler. Imbalances in air distribution result in reduced boiler efficiency, increased gas pollutant emission and operating problems, such as corrosion, slagging or fouling. Monitoring of air flow trends in boiler is an effective method for further analysis and can help to appoint important dependences and start optimization actions. Accurate real-time monitoring of the air distribution in boiler can bring economical, environmental and operational benefits. The paper presents a novel concept for online monitoring system of air distribution in coal-fired boiler based on real-time numerical calculations. The proposed mathematical model allows for identification of mass flow rates of secondary air to individual burners and to overfire air (OFA) nozzles. Numerical models of air and flue gas system were developed using software for power plant simulation. The correctness of the developed model was verified and validated with the reference measurement values. The presented numerical model for real-time monitoring of air distribution is capable of giving continuous determination of the complete air flows based on available digital communication system (DCS) data.

Clinical efficiency and safety analysis of transcatheter closure of multiple atrial septal defects in adults.

PubMed

Song, Zhi-Yuan; He, Guo-Xiang; Shu, Mao-Qin; Hu, Hou-Yuan; Tong, Shi-Fei; Ran, Bo-Li; Liu, Jian-Ping; Li, Yong-Hua; Jing, Tao

2009-03-01

Transcatheter closure of atrial septal defects (ASDs) is currently a reliable alternative to surgery, even though challenging in patients with multiple ASDs. The aim of this study was to evaluate the clinical efficiency and safety of transcatheter closure in multiple ASDs. Multiple ASDs were diagnosed by transthoracic echocardiography (TTE) or transesophageal echocardiography (TEE). The occlusive condition and distance between 2 adjacent ASDs were measured by TTE examination. Then, the number and size of the occluder(s) was determined. TTE examinations were performed after transcatheter closure as follow-up. The transcatheter procedure was successful in 15 patients with multiple ASDs, using a single occluder in 9 patients and 2 occluders in the remaining 6 patients. Overall, 21 ASD occluders were implanted. During a follow-up period of 6 mo to 5 y, a slight residual shunt was found in 1 patient without any symptoms; a moderate residual shunt was identified at the inferior vena cava and the occluder was removed by surgery 1 mo after procedure. Other complications, including endocarditis, arrhythmia, thromboembolism, and atrioventricular valve damage were not recorded in any of the 15 patients during the follow-up period. Transcatheter closure of multiple ASDs is safe and efficient. Two occluders are necessary for the distance of 2 ASDs more than 7 mm, and a single occluder is sufficient for those 7 mm or less. Copyright (c) 2009 Wiley Periodicals, Inc.

Building Operations Efficiencies into NASA's Ares I Crew Launch Vehicle Design

NASA Technical Reports Server (NTRS)

Dumbacher, Daniel

2006-01-01

The U.S. Vision for Space Exploration guides the National Aeronautics and Space Administration s (NASA's) challenging missions that expand humanity s boundaries and open new routes to the space frontier. With the Agency's commitment to complete the International Space Station (ISS) and to retire the venerable Space Shuttle by 2010, the NASA Administrator commissioned the Exploration Systems Architecture Study (ESAS) in mid 2005 to analyze options for safe, simple, cost-efficient launch solutions that could deliver human-rated space transportation capabilities in a timely manner within fixed budget guidelines. The Exploration Launch Projects Office, chartered in October 2005, has been conducting systems engineering studies and business planning over the past few months to successively refine the design configurations and better align vehicle concepts with customer and stakeholder requirements, such as significantly reduced life-cycle costs. As the Agency begins the process of replacing the Shuttle with a new generation of spacecraft destined for missions beyond low-Earth orbit to the Moon and Mars, NASA is designing the follow-on crew and cargo launch systems for maximum operational efficiencies. To sustain the long-term exploration of space, it is imperative to reduce the $4.5 billion NASA typically spends on space transportation each year. This paper gives top-level information about how the follow-on Ares I Crew Launch Vehicle (CLV) is being designed for improved safety and reliability, coupled with reduced operations costs.

Reliability based fatigue design and maintenance procedures

NASA Technical Reports Server (NTRS)

Hanagud, S.

1977-01-01

A stochastic model has been developed to describe a probability for fatigue process by assuming a varying hazard rate. This stochastic model can be used to obtain the desired probability of a crack of certain length at a given location after a certain number of cycles or time. Quantitative estimation of the developed model was also discussed. Application of the model to develop a procedure for reliability-based cost-effective fail-safe structural design is presented. This design procedure includes the reliability improvement due to inspection and repair. Methods of obtaining optimum inspection and maintenance schemes are treated.

Basic Information about Your Drinking Water

EPA Pesticide Factsheets

The United States enjoys one of the world's most reliable and safest supplies of drinking water. Congress passed the Safe Drinking Water Act (SDWA) in 1974 to protect public health, including by regulating public water systems.

Thunder and Lightning: A Lecture-Demonstration for All Ages.

ERIC Educational Resources Information Center

Baker, Colin

1999-01-01

Describes a series of simple but spectacular chemistry demonstrations designed to capture children's imaginations. The demonstrations take the minimum amount of time to prepare, are relatively safe to dispose of, and reliable. (Author/WRM)

NATO IST 124 Experimentation Instructions

DTIC Science & Technology

2016-11-10

more reliable and predictable network performance through adaptive and efficient control schemes . This report provides guidance and instructions for...tactical heterogeneous networks for more reliable and predictable network performance through adaptive and efficient control schemes . This report

Motor Carrier Efficiency Study Phase I

DOT National Transportation Integrated Search

2009-02-01

The Safe, Accountable, Flexible, Efficient Transportation Equity Act: A Legacy for Users (SAFETEA-LU, Public Law 109-59), Section 5503, set aside funding to examine the application of wireless technology to improve the safety and efficiency of trucki...

A safe and reliable neutralization assay based on pseudovirus to measure neutralizing antibody titer against poliovirus.

PubMed

Liu, Shaohua; Song, Dongmei; Bai, Han; Lu, Weiwei; Dai, Xinxian; Hao, Chunsheng; Zhang, Zhongyang; Guo, Huijie; Zhang, Yue; Li, Xiuling

2017-12-01

With the promotion of inactivated poliomyelitis vaccine (IPV) and live attenuated oral poliomyelitis vaccine (OPV), the global reported cases of poliomyelitis have reduced sharply from 0.35 million in 1988 to 74 in 2015. The Polio Eradication & Endgame Strategic Plan published by WHO in 2013 included the strategy of implementation of poliovirus safe handling and containment measures to minimize the risks of facility-associated reintroduction of virus into the polio-free community to prevent the re-import of poliovirus. Toward this strategy, we produced replication-incompetent pseudovirus of poliovirus type 1, 2, 3 attenuated strains by constructing poliovirus capsid expression vectors and poliovirus replicon then transfecting HEK293T cells and developed a pseudovirus-based neutralization assay (pNA) to determine neutralizing antibody titer which is more secure, time-saving and reliable than conventional neutralization assay (cNA). By using anti-poliovirus rat serum, we demonstrated excellent correlation between neutralizing antibody titers measured by cNA and pNA. It was concluded that pNA can be a potential alternative to replace cNA as a safe and time-saving system for titer determination after live poliovirus's safekeeping. © 2017 Wiley Periodicals, Inc.

Non-linear dynamic characteristics and optimal control of giant magnetostrictive film subjected to in-plane stochastic excitation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Z. W., E-mail: zhuzhiwen@tju.edu.cn; Tianjin Key Laboratory of Non-linear Dynamics and Chaos Control, 300072, Tianjin; Zhang, W. D., E-mail: zhangwenditju@126.com

2014-03-15

The non-linear dynamic characteristics and optimal control of a giant magnetostrictive film (GMF) subjected to in-plane stochastic excitation were studied. Non-linear differential items were introduced to interpret the hysteretic phenomena of the GMF, and the non-linear dynamic model of the GMF subjected to in-plane stochastic excitation was developed. The stochastic stability was analysed, and the probability density function was obtained. The condition of stochastic Hopf bifurcation and noise-induced chaotic response were determined, and the fractal boundary of the system's safe basin was provided. The reliability function was solved from the backward Kolmogorov equation, and an optimal control strategy was proposedmore » in the stochastic dynamic programming method. Numerical simulation shows that the system stability varies with the parameters, and stochastic Hopf bifurcation and chaos appear in the process; the area of the safe basin decreases when the noise intensifies, and the boundary of the safe basin becomes fractal; the system reliability improved through stochastic optimal control. Finally, the theoretical and numerical results were proved by experiments. The results are helpful in the engineering applications of GMF.« less

Exploratory Development on an Electronic Safing and Arming Device for Ordnance Fuzing

DTIC Science & Technology

1983-02-01

to the bridges. Two units were subjected to MIL-STD-331, Test 101, Jolt. The EBMs were placed in the S & A cavity of an M739 fuze body for this test...of the program was to explore a concept for a safe, reliable, general purpose, low cost, electronic, A ’ zsafing and arming ( S & A ) system for use in...breadboard model hardware of the electronic S & A device. The electronic S & A devicu consists of an explosive barrier moduls (EBM) explosive train

Threading needles in the dark: the effect of the physical work environment on nursing practice.

PubMed

Simmons, Debora; Graves, Krisanne; Flynn, Elizabeth A

2009-01-01

Frequently, the most critical calculations, considerations, and preparations for patient care and medication administration are made in noisy, dimly lit, and chaotic areas of the nursing unit. Healthcare has begun to recognize the impact of the physical work environment plays in the ability of humans to perform reliably and safely. This article reviews the draft guidelines recently released by the United States Pharmacopeia for public comment for the physical environment to promote safe medication administration.

Fission Surface Power for the Exploration and Colonization of Mars

NASA Technical Reports Server (NTRS)

Houts, Mike; Porter, Ron; Gaddis, Steve; Van Dyke, Melissa; Martin, Jim; Godfroy, Tom; Bragg-Sitton, Shannon; Garber, Anne; Pearson, Boise

2006-01-01

The colonization of Mars will require abundant energy. One potential energy source is nuclear fission. Terrestrial fission systems are highly developed and have the demonstrated ability to safely produce tremendous amounts of energy. In space, fission systems not only have the potential to safely generate tremendous amounts of energy, but could also potentially be used on missions where alternatives are not practical. Programmatic risks such as cost and schedule are potential concerns with fission surface power (FSP) systems. To be mission enabling, FSP systems must be affordable and programmatic risk must be kept acceptably low to avoid jeopardizing exploration efforts that may rely on FSP. Initial FSP systems on Mars could be "workhorse" units sized to enable the establishment of a Mars base and the early growth of a colony. These systems could be nearly identical to FSP systems used on the moon. The systems could be designed to be safe, reliable, and have low development and recurring costs. Systems could also be designed to fit on relatively small landers. One potential option for an early Mars FSP system would be a 100 kWt class, NaK cooled system analogous to space reactors developed and flown under the U.S. "SNAP" program or those developed and flown by the former Soviet Union ("BUK" reactor). The systems could use highly developed fuel and materials. Water and Martian soil could be used to provide shielding. A modern, high-efficiency power conversion subsystem could be used to reduce required reactor thermal power. This, in turn, would reduce fuel burnup and radiation damage .effects by reducing "nuclear" fuels and materials development costs. A realistic, non-nuclear heated and fully integrated technology demonstration unit (TDU) could be used to reduce cost and programmatic uncertainties prior to initiating a flight program.

Linear FMCW Laser Radar for Precision Range and Vector Velocity Measurements

NASA Technical Reports Server (NTRS)

Pierrottet, Diego; Amzajerdian, Farzin; Petway, Larry; Barnes, Bruce; Lockhard, George; Rubio, Manuel

2008-01-01

An all fiber linear frequency modulated continuous wave (FMCW) coherent laser radar system is under development with a goal to aide NASA s new Space Exploration initiative for manned and robotic missions to the Moon and Mars. By employing a combination of optical heterodyne and linear frequency modulation techniques and utilizing state-of-the-art fiber optic technologies, highly efficient, compact and reliable laser radar suitable for operation in a space environment is being developed. Linear FMCW lidar has the capability of high-resolution range measurements, and when configured into a multi-channel receiver system it has the capability of obtaining high precision horizontal and vertical velocity measurements. Precision range and vector velocity data are beneficial to navigating planetary landing pods to the preselected site and achieving autonomous, safe soft-landing. The all-fiber coherent laser radar has several important advantages over more conventional pulsed laser altimeters or range finders. One of the advantages of the coherent laser radar is its ability to measure directly the platform velocity by extracting the Doppler shift generated from the motion, as opposed to time of flight range finders where terrain features such as hills, cliffs, or slopes add error to the velocity measurement. Doppler measurements are about two orders of magnitude more accurate than the velocity estimates obtained by pulsed laser altimeters. In addition, most of the components of the device are efficient and reliable commercial off-the-shelf fiber optic telecommunication components. This paper discusses the design and performance of a second-generation brassboard system under development at NASA Langley Research Center as part of the Autonomous Landing and Hazard Avoidance (ALHAT) project.

Department of Defense meteorological and environmental inputs to aviation systems

NASA Technical Reports Server (NTRS)

Try, P. D.

1983-01-01

Recommendations based on need, cost, and achievement of flight safety are offered, and the re-evaluation of weather parameters needed for safe landing operations that lead to reliable and consistent automated observation capabilities are considered.

Aeromedical transportation and general aviation.

DOT National Transportation Integrated Search

1971-04-01

The advantages of aircraft in providing military medical evacuation are well documented. Training and experience have resulted in a reliable and safe military medical evacuation system. Many studies have been done or are in process which pertain to c...

TXDOT ITS strategic plan 2013.

DOT National Transportation Integrated Search

2014-04-01

TxDOTs mission is to provide safe and reliable transportation solutions for the citizens of Texas. Intelligent transportation systems (ITS) can play a pivotal role in meeting that mission. TxDOT can take advantage of advanced and emerging technolo...

A Discussion of Two Challenges of Non-cooperative Satellite Refueling

NASA Technical Reports Server (NTRS)

Coll, Gregory C.; Aranyos, Thomas; Nufer, Brian M.; Kandula, Max; Tomasic, David J.

2015-01-01

There is interest from government and commercial aerospace communities in advancing propellant transfer technology for in-orbit refueling of satellites. This paper introduces two challenges to a Propellant Transfer System (PTS) under development for demonstration of non-cooperative satellite refueling. The PTS is being developed to transfer storable propellant (heritage hypergolic fuels and oxidizers as well as xenon) safely and reliably from one servicer satellite to a non-cooperative typical existing client satellite. NASA is in the project evaluation planning stages for conducting a first time on-orbit demonstration to an existing government asset. The system manages pressure, flow rate totalization, temperature and other parameters to control the condition of the propellant being transferred to the client. It keeps the propellant isolated while performing leak checks of itself and the client interface before transferring propellant. A major challenge is to design a safe, reliable system with some new technologies while maintaining a reasonable cost.

A Discussion of Two Challenges of Non-Cooperative Satellite Refueling

NASA Technical Reports Server (NTRS)

Coll, Gregory T.; Aranyos, Thomas J.; Nufer, Brian M.; Tomasic, David; Kandula, Max

2015-01-01

There is interest from government and commercial aerospace communities in advancing propellant transfer technology for in-orbit refueling of satellites. This paper introduces two challenges to a Propellant Transfer System (PTS) under development for demonstration of non-cooperative satellite refueling. The PTS is being developed to transfer storable propellant (heritage hypergolic fuels and oxidizers as well as xenon) safely and reliably from one servicer satellite to a non-cooperative typical existing client satellite. NASA is in the project evaluation planning stages for conducting a first time on-orbit demonstration to an existing government asset. The system manages pressure, flow rate totalization, temperature and other parameters to control the condition of the propellant being transferred to the client. It keeps the propellant isolated while performing leak checks of itself and the client interface before transferring propellant. A major challenge is to design a safe, reliable system with some new technologies while maintaining a reasonable cost.

Coal-Powered Electric Generating Unit Efficiency and Reliability Dialogue: Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, Emmanuel

Coal continues to play a critical role in powering the Nation’s electricity generation, especially for baseload power plants. With aging coal generation assets facing decreased performance due to the state of the equipment, and with challenges exacerbated by the current market pressures on the coal sector, there are opportunities to advance early-stage technologies that can retrofit or replace equipment components. These changes will eventually result in significant improvements in plant performance once further developed and deployed by industry. Research and development in areas such as materials, fluid dynamics, fuel properties and preparation characteristics, and a new generation of plant controlsmore » can lead to new components and systems that can help improve the efficiency and reliability of coal-fired power plants significantly, allowing these assets to continue to provide baseload power. Coal stockpiles at electricity generation plants are typically large enough to provide 30 to 60 days of power prior to resupply—significantly enhancing the stability and reliability of the U.S. electricity sector. Falling prices for non-dispatchable renewable energy and mounting environmental regulations, among other factors, have stimulated efforts to improve the efficiency of these coal-fired electric generating units (EGUs). In addition, increased reliance on natural gas and non-dispatchable energy sources has spurred efforts to further increase the reliability of coal EGUs. The Coal Powered EGU Efficiency and Reliability Dialogue brought together stakeholders from across the coal EGU industry to discuss methods for improvement. Participants at the event reviewed performance-enhancing innovations in coal EGUs, discussed the potential for data-driven management practices to increase efficiency and reliability, investigated the impacts of regulatory compliance on coal EGU performance, and discussed upcoming challenges for the coal industry. This report documents the key findings and research suggestions discussed at the event. Discussions at the workshop will aid DOE in developing a set of distinct initiatives that can be pursued by government and industry to realize promising technological pursuits. DOE plans to use the results of the Dialogue coupled with ongoing technical analysis of efficiency opportunities within the coal-fired fleet, and additional studies to develop a comprehensive strategy for capitalizing on thermal efficiency improvements. Expected Power Plant Efficiency Improvements include developing cost-effective, efficient, and reliable technologies for boilers, turbines, and sensors and controls to improve the reliability and efficiency of existing coal-based power plants. The Office of Fossil Energy at DOE plans to work with industry to develop knowledge pertaining to advanced technologies and systems that industry can subsequently develop. These technologies and systems will increase reliability, add operational flexibility and improve efficiency, thereby providing more robust power generation infrastructure. The following table lists the research suggestions and questions for further investigation that were identified by participants in each session of the dialogue.« less

Reliability improvements on Thales RM2 rotary Stirling coolers: analysis and methodology

NASA Astrophysics Data System (ADS)

Cauquil, J. M.; Seguineau, C.; Martin, J.-Y.; Benschop, T.

2016-05-01

The cooled IR detectors are used in a wide range of applications. Most of the time, the cryocoolers are one of the components dimensioning the lifetime of the system. The cooler reliability is thus one of its most important parameters. This parameter has to increase to answer market needs. To do this, the data for identifying the weakest element determining cooler reliability has to be collected. Yet, data collection based on field are hardly usable due to lack of informations. A method for identifying the improvement in reliability has then to be set up which can be used even without field return. This paper will describe the method followed by Thales Cryogénie SAS to reach such a result. First, a database was built from extensive expertizes of RM2 failures occurring in accelerate ageing. Failure modes have then been identified and corrective actions achieved. Besides this, a hierarchical organization of the functions of the cooler has been done with regard to the potential increase of its efficiency. Specific changes have been introduced on the functions most likely to impact efficiency. The link between efficiency and reliability will be described in this paper. The work on the two axes - weak spots for cooler reliability and efficiency - permitted us to increase in a drastic way the MTTF of the RM2 cooler. Huge improvements in RM2 reliability are actually proven by both field return and reliability monitoring. These figures will be discussed in the paper.

Perineal pseudocontinent colostomy is safe and efficient technique for perineal reconstruction after abdominoperineal resection for rectal adenocarcinoma.

PubMed

Souadka, Amine; Majbar, Mohammed Anass; El Harroudi, Tijani; Benkabbou, Amine; Souadka, Abdelilah

2015-04-10

The aim of this study was to evaluate oncologic results and satisfaction rate results of pseudocontinent perineal colostomy (PCPC) using Schmidt's technique in patients undergoing abdominoperineal resection (APR) for managing low rectal adenocarcinoma. From January 1993 and December 2007, One hundred and forty six patients underwent successfully PCPC after abdominoperineal resection for lower rectal adenocarcinoma. There were 75 women, with an average age of 47 years old. All patients received neoadjuvant radiotherapy with or without chemotherapy. Long-term oncological results and satisfaction rate were evaluated. After a median follow up of 36 months (range 12-156) months, the five-year overall survival and disease free survival rate were 74.6% and 60.3% respectively. Local and distant recurrences occurred respectively in 10 (6,8%) and 29 (20%) patients. Seventy-seven percent (77%) of the patients were highly satisfied with this technique and only one patient was unsatisfied. However, none of them accepted the conversion to an abdominal colostomy neither would have changed PCPC for an iliac colostomy at first intent. This study showed that pseudocontinent perineal colostomy is a safe and reliable pelvic reconstruction technique after abdominoperineal resection for low rectal adenocarcinoma. It provides high degree of patient satisfaction without compromising oncological results. It is a good option in selected patients, especially in Muslim countries.

Airport Traffic Conflict Detection and Resolution Algorithm Evaluation

NASA Technical Reports Server (NTRS)

Jones, Denise R.; Chartrand, Ryan C.; Wilson, Sara R.; Commo, Sean A.; Otero, Sharon D.; Barker, Glover D.

2012-01-01

A conflict detection and resolution (CD&R) concept for the terminal maneuvering area (TMA) was evaluated in a fast-time batch simulation study at the National Aeronautics and Space Administration (NASA) Langley Research Center. The CD&R concept is being designed to enhance surface situation awareness and provide cockpit alerts of potential conflicts during runway, taxi, and low altitude air-to-air operations. The purpose of the study was to evaluate the performance of aircraft-based CD&R algorithms in the TMA, as a function of surveillance accuracy. This paper gives an overview of the CD&R concept, simulation study, and results. The Next Generation Air Transportation System (NextGen) concept for the year 2025 and beyond envisions the movement of large numbers of people and goods in a safe, efficient, and reliable manner [1]. NextGen will remove many of the constraints in the current air transportation system, support a wider range of operations, and provide an overall system capacity up to three times that of current operating levels. Emerging NextGen operational concepts [2], such as four-dimensional trajectory based airborne and surface operations, equivalent visual operations, and super density arrival and departure operations, require a different approach to air traffic management and as a result, a dramatic shift in the tasks, roles, and responsibilities for the flight deck and air traffic control (ATC) to ensure a safe, sustainable air transportation system.

On the next generation of reliability analysis tools

NASA Technical Reports Server (NTRS)

Babcock, Philip S., IV; Leong, Frank; Gai, Eli

1987-01-01

The current generation of reliability analysis tools concentrates on improving the efficiency of the description and solution of the fault-handling processes and providing a solution algorithm for the full system model. The tools have improved user efficiency in these areas to the extent that the problem of constructing the fault-occurrence model is now the major analysis bottleneck. For the next generation of reliability tools, it is proposed that techniques be developed to improve the efficiency of the fault-occurrence model generation and input. Further, the goal is to provide an environment permitting a user to provide a top-down design description of the system from which a Markov reliability model is automatically constructed. Thus, the user is relieved of the tedious and error-prone process of model construction, permitting an efficient exploration of the design space, and an independent validation of the system's operation is obtained. An additional benefit of automating the model construction process is the opportunity to reduce the specialized knowledge required. Hence, the user need only be an expert in the system he is analyzing; the expertise in reliability analysis techniques is supplied.

Reliability and cost-effectiveness of sentinel lymph node excision under local anaesthesia versus general anaesthesia for malignant melanoma: a retrospective analysis in 300 patients with malignant melanoma AJCC Stages I and II.

PubMed

Stoffels, I; Dissemond, J; Körber, A; Hillen, U; Poeppel, T; Schadendorf, D; Klode, J

2011-03-01

Sentinel lymph node excision (SLNE) for the detection of regional nodal metastases and staging of malignant melanoma has resulted in some controversies in international discussions, as it is a cost-intensive surgical intervention with potentially significant morbidity. The present retrospective study seeks to clarify the effectiveness and reliability of SLNE performed under tumescent local anaesthesia (TLA) and whether SLNE performed under TLA can reduce costs and morbidity. Therefore, our study is a comparison of SLNE performed under TLA and general anaesthesia (GA). We retrospectively analysed data from 300 patients with primary malignant melanoma with a Breslow index of ≥1.0 mm. Altogether, 211 (70.3%) patients underwent SLNE under TLA and 89 (29.7%) patients underwent SLNE under GA. A total of 637 sentinel lymph nodes (SLN) were removed. In the TLA group 1.98 SLN/patient and in the GA group 2.46 SLN/patient were removed (median value). Seventy patients (23.3%) had a positive SLN. No major complications occurred. The costs for SLNE were significantly less for the SLNE in a procedures room performed under TLA (mean € 30.64) compared with SLNE in an operating room under GA (mean € 326.14, P<0.0001). In conclusion, SLNE performed under TLA is safe, reliable, and cost-efficient and could become the new gold standard in sentinel lymph node diagnostic procedures. © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

Separating predictable and unpredictable work to manage interruptions and promote safe and effective work flow.

PubMed

Kowinsky, Amy M; Shovel, Judith; McLaughlin, Maribeth; Vertacnik, Lisa; Greenhouse, Pamela K; Martin, Susan Christie; Minnier, Tamra E

2012-01-01

Predictable and unpredictable patient care tasks compete for caregiver time and attention, making it difficult for patient care staff to reliably and consistently meet patient needs. We have piloted a redesigned care model that separates the work of patient care technicians based on task predictability and creates role specificity. This care model shows promise in improving the ability of staff to reliably complete tasks in a more consistent and timely manner.

A reliable and safe gastrotomy closure technique assessed in a porcine survival model pilot study: success of the Queen's closure.

PubMed

Hookey, L C; Bielawska, B; Samis, A; Jalink, D; Ellis, R; Khokhotva, V; Hurlbut, D; Mercer, D

2009-06-01

The evolution of NOTES to clinical implementation has been hampered by lack of a reliable, safe, and easy-to-implement technique for closure of the opening created in accessing the peritoneum. The Queen's closure uses a combination of endoscopic clips and loop devices to seal such defects in the stomach wall. This study aimed to assess the Queen's closure in a porcine survival model. Five 30-kg pigs underwent endoscopic transgastric surgery with exploration of the peritoneum. The endoscope was then withdrawn back into the stomach and the closure performed. The animals were recovered, monitored closely, and underwent endoscopy 1 week after surgery. They were then euthanized at 2 (n = 2) and 3 (n = 3) weeks after surgery with subsequent necropsy. The mean procedure time (from intubation of the esophagus to withdrawal of the endoscope) was 79 minutes (range 45-105 minutes) with a mean time of exploration of the peritoneum of 14 minutes (range 8-25 minutes). All animals recovered well with no apparent pain, distress, or signs of infection. Endoscopic examination 1 week after surgery revealed all the closures to be intact and only identifiable by a small ulcer. At necropsy, the gastrotomy site was identifiable only by minor serosal adhesions. Histological study demonstrated full-thickness closure with minimal inflammation. The Queen's closure is a reliable and safe technique that provides full-thickness gastrotomy closure without any observed complications. The technique has proven to be transferable knowledge that holds promise for clinical implementation.

78 FR 77574 - Protection System Maintenance Reliability Standard

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... protection system component type, except that the maintenance program for all batteries associated with the... Electric System reliability and promoting efficiency through consolidation [of protection system-related... ITC that PRC-005-2 promotes efficiency by consolidating protection system maintenance requirements...

Developing a reliable method for signal wire attachment : [research results].

DOT National Transportation Integrated Search

2013-03-01

Railroad signaling systems detect trains on the track, identify track fractures, prevent derailments, and alert signal crossing stations when trains approach. These systems are vital to safe train operation; therefore, each component of this system h...

Safety evaluation of high-speed rail bogie concepts.

DOT National Transportation Integrated Search

2013-10-01

The study defines the basic design concepts required to provide a safe, reliable, high-speed bogie for the next generation PRIIA passenger locomotive. The requirements and conditions for the U.S. market create unique design challenges that currently ...

Choices for Mobility Independence: Transportation Options for Older Adults and People with Disabilities

MedlinePlus

... Organization. Photo credit: The Center for Volunteer Caregiving, Cary, NC (man entering car); Ryan Byers, Pocatello, ID ( ... Waite Park, MN; The Center for Volunteer Caregiving, Cary, NC Key Considerations. Safe, reliable transportation is critica ...

High reliability and implications for nursing leaders.

PubMed

Riley, William

2009-03-01

To review high reliability theory and discuss its implications for the nursing leader. A high reliability organization (HRO) is considered that which has measurable near perfect performance for quality and safety. The author has reviewed the literature, discussed research findings that contribute to improving reliability in health care organizations, and makes five recommendations for how nursing leaders can create high reliability organizations. Health care is not a safe industry and unintended patient harm occurs at epidemic levels. Health care can learn from high reliability theory and practice developed in other high-risk industries. Viewed by HRO standards, unintended patient injury in health care is excessively high and quality is distressingly low. HRO theory and practice can be successfully applied in health care using advanced interdisciplinary teamwork training and deliberate process design techniques. Nursing has a primary leadership function for ensuring patient safety and achieving high quality in health care organizations. Learning HRO theory and methods for achieving high reliability is a foremost opportunity for nursing leaders.

High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring.

PubMed

Feng, Gang; Hao, Lan; Xu, Chunyan; Ran, Haitao; Zheng, Yuanyi; Li, Pan; Cao, Yang; Wang, Qi; Xia, Jizhu; Wang, Zhigang

2017-01-01

High-intensity focused ultrasound (HIFU) is widely applied to tumors in clinical practice due to its minimally invasive approach. However, several issues lower therapeutic efficiency in some cases. Many synergists such as microbubbles and perfluorocarbon nanoparticles have recently been used to improve HIFU treatment efficiency, but none were determined to be effective and safe in vivo. In this study, nanoscale bubble-generating liposomes (liposomes containing ammonium bicarbonate [Lip-ABC]) were prepared by film hydration followed by sequential extrusion. Their stable nanoscale particle diameter was confirmed, and their bubble-generating capacity after HIFU triggering was demonstrated with ultrasound imaging. Lip-ABC had good stability in vivo and accumulated in the tumor interstitial space based on the enhanced permeability and retention effect evaluated by photoacoustic imaging. When used to synergize HIFU ablation to bovine liver in vitro and implanted breast tumors of BALB/c nude mice, Lip-ABC outperformed the control. Importantly, all mice survived HIFU treatment, suggesting that Lip-ABC is a safe HIFU synergist.

Roadmap to a Sustainable Structured Trusted Employee Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, Cameron W; Eisele, Gerhard R

2013-08-01

Organizations (facility, regulatory agency, or country) have a compelling interest in ensuring that individuals who occupy sensitive positions affording access to chemical biological, radiological and nuclear (CBRN) materials facilities and programs are functioning at their highest level of reliability. Human reliability and human performance relate not only to security but also focus on safety. Reliability has a logical and direct relationship to trustworthiness for the organization is placing trust in their employees to conduct themselves in a secure, safe, and dependable manner. This document focuses on providing an organization with a roadmap to implementing a successful and sustainable Structured Trustedmore » Employee Program (STEP).« less

Summary of NASA Aerospace Flight Battery Systems Program activities

NASA Technical Reports Server (NTRS)

Manzo, Michelle; Odonnell, Patricia

1994-01-01

A summary of NASA Aerospace Flight Battery Systems Program Activities is presented. The NASA Aerospace Flight Battery Systems Program represents a unified NASA wide effort with the overall objective of providing NASA with the policy and posture which will increase the safety, performance, and reliability of space power systems. The specific objectives of the program are to: enhance cell/battery safety and reliability; maintain current battery technology; increase fundamental understanding of primary and secondary cells; provide a means to bring forth advanced technology for flight use; assist flight programs in minimizing battery technology related flight risks; and ensure that safe, reliable batteries are available for NASA's future missions.

Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia.

PubMed

Walsh, Michele C; Wilson-Costello, Deanna; Zadell, Arlene; Newman, Nancy; Fanaroff, Avroy

2003-09-01

Bronchopulmonary dysplasia (BPD) is the focus of many intervention trials, yet the outcome measure when based solely on oxygen administration may be confounded by differing criteria for oxygen administration between physicians. Thus, we wished to define BPD by a standardized oxygen saturation monitoring at 36 weeks corrected age, and compare this physiologic definition with the standard clinical definition of BPD based solely on oxygen administration. A total of 199 consecutive very low birthweight infants (VLBW, 501 to 1500 g birthweight) were assessed prospectively at 36+/-1 weeks corrected age. Neonates on positive pressure support or receiving >30% supplemental oxygen were assigned the outcome BPD. Those receiving < or =30% oxygen underwent a stepwise 2% reduction in supplemental oxygen to room air while under continuous observation and oxygen saturation monitoring. Outcomes of the test were "no BPD" (saturations > or =88% for 60 minutes) or "BPD" (saturation < 88%). At the conclusion of the test, all infants were returned to their baseline oxygen. Safety (apnea, bradycardia, increased oxygen use), inter-rater reliability, test-retest reliability, and validity of the physiologic definition vs the clinical definition were assessed. A total of 199 VLBW were assessed, of whom 45 (36%) were diagnosed with BPD by the clinical definition of oxygen use at 36 weeks corrected age. The physiologic definition identified 15 infants treated with oxygen who successfully passed the saturation monitoring test in room air. The physiologic definition diagnosed BPD in 30 (24%) of the cohort. All infants were safely studied. The test was highly reliable (inter-rater reliability, kappa=1.0; test-retest reliability, kappa=0.83) and highly correlated with discharge home in oxygen, length of hospital stay, and hospital readmissions in the first year of life. The physiologic definition of BPD is safe, feasible, reliable, and valid and improves the precision of the diagnosis of BPD. This may be of benefit in future multicenter clinical trials.

Scheduling for energy and reliability management on multiprocessor real-time systems

NASA Astrophysics Data System (ADS)

Qi, Xuan

Scheduling algorithms for multiprocessor real-time systems have been studied for years with many well-recognized algorithms proposed. However, it is still an evolving research area and many problems remain open due to their intrinsic complexities. With the emergence of multicore processors, it is necessary to re-investigate the scheduling problems and design/develop efficient algorithms for better system utilization, low scheduling overhead, high energy efficiency, and better system reliability. Focusing cluster schedulings with optimal global schedulers, we study the utilization bound and scheduling overhead for a class of cluster-optimal schedulers. Then, taking energy/power consumption into consideration, we developed energy-efficient scheduling algorithms for real-time systems, especially for the proliferating embedded systems with limited energy budget. As the commonly deployed energy-saving technique (e.g. dynamic voltage frequency scaling (DVFS)) will significantly affect system reliability, we study schedulers that have intelligent mechanisms to recuperate system reliability to satisfy the quality assurance requirements. Extensive simulation is conducted to evaluate the performance of the proposed algorithms on reduction of scheduling overhead, energy saving, and reliability improvement. The simulation results show that the proposed reliability-aware power management schemes could preserve the system reliability while still achieving substantial energy saving.

A testing-coverage software reliability model considering fault removal efficiency and error generation.

PubMed

Li, Qiuying; Pham, Hoang

2017-01-01

In this paper, we propose a software reliability model that considers not only error generation but also fault removal efficiency combined with testing coverage information based on a nonhomogeneous Poisson process (NHPP). During the past four decades, many software reliability growth models (SRGMs) based on NHPP have been proposed to estimate the software reliability measures, most of which have the same following agreements: 1) it is a common phenomenon that during the testing phase, the fault detection rate always changes; 2) as a result of imperfect debugging, fault removal has been related to a fault re-introduction rate. But there are few SRGMs in the literature that differentiate between fault detection and fault removal, i.e. they seldom consider the imperfect fault removal efficiency. But in practical software developing process, fault removal efficiency cannot always be perfect, i.e. the failures detected might not be removed completely and the original faults might still exist and new faults might be introduced meanwhile, which is referred to as imperfect debugging phenomenon. In this study, a model aiming to incorporate fault introduction rate, fault removal efficiency and testing coverage into software reliability evaluation is developed, using testing coverage to express the fault detection rate and using fault removal efficiency to consider the fault repair. We compare the performance of the proposed model with several existing NHPP SRGMs using three sets of real failure data based on five criteria. The results exhibit that the model can give a better fitting and predictive performance.

30 CFR 74.9 - Quality assurance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... specifications and are reliable, safe, effective, and otherwise suitable for their intended use. To establish and... registration under ISO Q9001-2000, American National Standard, Quality Management Systems-Requirements... ISO Q9001-2000, American National Standard, Quality Management Systems-Requirements. The Director of...

Simplifying the Ambiguous Law, Keeping Everyone Reliably Safe Act of 2010

THOMAS, 111th Congress

Rep. Sanchez, Loretta [D-CA-47

2010-07-01

Senate - 07/28/2010 Received in the Senate and Read twice and referred to the Committee on the Judiciary. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Research to develop an ITS strategic plan for Texas.

DOT National Transportation Integrated Search

2014-04-01

TxDOTs mission is to provide safe and reliable transportation solutions for the citizens of Texas. Intelligent : transportation systems (ITS) can play a pivotal role in meeting that mission. TxDOT can take advantage of : advanced and emerging tech...

Transit and climate change adaptation : synthesis of FTA-funded pilot projects.

DOT National Transportation Integrated Search

2014-08-01

Public transit agencies play a critical role in providing safe, reliable, and cost-effective transportation to the communities they serve. In : the face of increased frequency and intensity of extreme weather events, several public transit and other ...

Risk-based asset management methodology for highway infrastructure systems.

DOT National Transportation Integrated Search

2004-01-01

Maintaining the infrastructure of roads, highways, and bridges is paramount to ensuring that these assets will remain safe and reliable in the future. If maintenance costs remain the same or continue to escalate, and additional funding is not made av...

Prediction and mitigation of scour and scour damage to Vermont bridges.

DOT National Transportation Integrated Search

2017-02-20

Over 300 Vermont bridges were damaged in the 2011 Tropical Storm Irene and many experienced significant scour. Successfully mitigating bridge scour in future flooding events depends on our ability to reliably estimate scour potential, design safe and...

Reliability, Safety and Error Recovery for Advanced Control Software

NASA Technical Reports Server (NTRS)

Malin, Jane T.

2003-01-01

For long-duration automated operation of regenerative life support systems in space environments, there is a need for advanced integration and control systems that are significantly more reliable and safe, and that support error recovery and minimization of operational failures. This presentation outlines some challenges of hazardous space environments and complex system interactions that can lead to system accidents. It discusses approaches to hazard analysis and error recovery for control software and challenges of supporting effective intervention by safety software and the crew.

OS Aviation Information

Science.gov Websites

Aviation Weather Program is to couple the art and science of meteorology to enhance the safe and efficient significant weather forecasts crossing international boundaries. Keeping Our National Airspace System Safe The System Newsletter Aviation Weather Center (AWC) Alaska Aviation Weather Unit (AAWU) Space Environment

FAA Directives System

DOT National Transportation Integrated Search

1992-08-26

Consistent with the Federal Aviation Administration's mission to foster a safe, : secure, and efficient aviation system is the need for an effective and efficient : process for communitcating policy and procedures. The FAA Directives System : provide...

Design of a Glenn Research Center Solar Field Grid-Tied Photovoltaic Power System

NASA Technical Reports Server (NTRS)

Eichenberg, Dennis J.

2009-01-01

The NASA Glenn Research Center (GRC) designed, developed, and installed, a 37.5 kW DC photovoltaic (PV) Solar Field in the GRC West Area in the 1970s for the purpose of testing PV panels for various space and terrestrial applications. The PV panels are arranged to provide a nominal 120 VDC. The GRC Solar Field has been extremely successful in meeting its mission. The PV panels and the supporting electrical systems are all near their end of life. GRC has designed a 72 kW DC grid-tied PV power system to replace the existing GRC West Area Solar Field. The 72 kW DC grid-tied PV power system will provide DC solar power for GRC PV testing applications, and provide AC facility power for all times that research power is not required. A grid-tied system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility for use by all. The project transfers space technology to terrestrial use via nontraditional partners. GRC personnel glean valuable experience with PV power systems that are directly applicable to various space power systems, and provide valuable space program test data. PV power systems help to reduce harmful emissions and reduce the Nation s dependence on fossil fuels. Power generated by the PV system reduces the GRC utility demand, and the surplus power aids the community. Present global energy concerns reinforce the need for the development of alternative energy systems. Modern PV panels are readily available, reliable, efficient, and economical with a life expectancy of at least 25 years. Modern electronics has been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy of at least 25 years. The report concludes that the GRC West Area grid-tied PV power system design is viable for a reliable, maintenance free, long life power system that is of significant value to NASA and the community.

Transportation of Organs by Air: Safety, Quality, and Sustainability Criteria.

PubMed

Mantecchini, L; Paganelli, F; Morabito, V; Ricci, A; Peritore, D; Trapani, S; Montemurro, A; Rizzo, A; Del Sordo, E; Gaeta, A; Rizzato, L; Nanni Costa, A

2016-03-01

The outcomes of organ transplantation activities are greatly affected by the ability to haul organs and medical teams quickly and safely. Organ allocation and usage criteria have greatly improved over time, whereas the same result has not been achieved so far from the transport point of view. Safety and the highest level of service and efficiency must be reached to grant transplant recipients the healthiest outcome. The Italian National Transplant Centre (CNT), in partnership with the regions and the University of Bologna, has promoted a thorough analysis of all stages of organ transportation logistics chains to produce homogeneous and shared guidelines throughout the national territory, capable of ensuring safety, reliability, and sustainability at the highest levels. The mapping of all 44 transplant centers and the pertaining airport network has been implemented. An analysis of technical requirements among organ shipping agents at both national and international level has been promoted. A national campaign of real-time monitoring of organ transport activities at all stages of the supply chain has been implemented. Parameters investigated have been hospital and region of both origin and destination, number and type of organs involved, transport type (with or without medical team), stations of arrival and departure, and shipping agents, as well as actual times of activities involved. National guidelines have been issued to select organ storage units and shipping agents on the basis of evaluation of efficiency, reliability, and equipment with reference to organ type and ischemia time. Guidelines provide EU-level standards on technical equipment of aircrafts, professional requirements of shipping agencies and cabin crew, and requirements on service provision, including pricing criteria. The introduction in the Italian legislation of guidelines issuing minimum requirements on topics such as the medical team, packaging, labeling, safety and integrity, identification, real-time monitoring of temperature, and traceability of the organ during the logistics chain is deemed a valid response to the necessity of improving safety, reliability, and sustainability of organ transplantation activities in Italy. Copyright © 2016 Elsevier Inc. All rights reserved.

Grid-Tied Photovoltaic Power System

NASA Technical Reports Server (NTRS)

Eichenberg, Dennis J.

2011-01-01

A grid-tied photovoltaic (PV) power system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility. Operating costs of a PV power system are low compared to conventional power technologies. This method can displace the highest-cost electricity during times of peak demand in most climatic regions, and thus reduce grid loading. Net metering is often used, in which independent power producers such as PV power systems are connected to the utility grid via the customers main service panels and meters. When the PV power system is generating more power than required at that location, the excess power is provided to the utility grid. The customer pays the net of the power purchased when the on-site power demand is greater than the onsite power production, and the excess power is returned to the utility grid. Power generated by the PV system reduces utility demand, and the surplus power aids the community. Modern PV panels are readily available, reliable, efficient, and economical, with a life expectancy of at least 25 years. Modern electronics have been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy equal to the modern PV panels. The grid-tied PV power system was successfully designed and developed, and this served to validate the basic principles developed, and the theoretical work that was performed. Grid-tied PV power systems are reliable, maintenance- free, long-life power systems, and are of significant value to NASA and the community. Of particular value are the analytical tools and capabilities that have been successfully developed. Performance predictions can be made confidently for grid-tied PV systems of various scales. The work was done under the NASA Hybrid Power Management (HPM) Program, which is the integration of diverse power devices in an optimal configuration for space and terrestrial applications.

An Intelligent Robotic Hospital Bed for Safe Transportation of Critical Neurosurgery Patients Along Crowded Hospital Corridors.

PubMed

Wang, Chao; Savkin, Andrey V; Clout, Ray; Nguyen, Hung T

2015-09-01

We present a novel design of an intelligent robotic hospital bed, named Flexbed, with autonomous navigation ability. The robotic bed is developed for fast and safe transportation of critical neurosurgery patients without changing beds. Flexbed is more efficient and safe during the transportation process comparing to the conventional hospital beds. Flexbed is able to avoid en-route obstacles with an efficient easy-to-implement collision avoidance strategy when an obstacle is nearby and to move towards its destination at maximum speed when there is no threat of collision. We present extensive simulation results of navigation of Flexbed in the crowded hospital corridor environments with moving obstacles. Moreover, results of experiments with Flexbed in the real world scenarios are also presented and discussed.

Reliability of Growth Indicators and Efficiency of Functional Treatment for Skeletal Class II Malocclusion: Current Evidence and Controversies.

PubMed

Perinetti, Giuseppe; Contardo, Luca

2017-01-01

Current evidence on the reliability of growth indicators in the identification of the pubertal growth spurt and efficiency of functional treatment for skeletal Class II malocclusion, the timing of which relies on such indicators, is highly controversial. Regarding growth indicators, the hand and wrist (including the sole middle phalanx of the third finger) maturation method and the standing height recording appear to be most reliable. Other methods are subjected to controversies or were showed to be unreliable. Main sources of controversies include use of single stages instead of ossification events and diagnostic reliability conjecturally based on correlation analyses. Regarding evidence on the efficiency of functional treatment, when treated during the pubertal growth spurt, more favorable response is seen in skeletal Class II patients even though large individual responsiveness remains. Main sources of controversies include design of clinical trials, definition of Class II malocclusion, and lack of inclusion of skeletal maturity among the prognostic factors. While no growth indicator may be considered to have a full diagnostic reliability in the identification of the pubertal growth spurt, their use may still be recommended for increasing efficiency of functional treatment for skeletal Class II malocclusion.

Reliability of Growth Indicators and Efficiency of Functional Treatment for Skeletal Class II Malocclusion: Current Evidence and Controversies

PubMed Central

2017-01-01

Current evidence on the reliability of growth indicators in the identification of the pubertal growth spurt and efficiency of functional treatment for skeletal Class II malocclusion, the timing of which relies on such indicators, is highly controversial. Regarding growth indicators, the hand and wrist (including the sole middle phalanx of the third finger) maturation method and the standing height recording appear to be most reliable. Other methods are subjected to controversies or were showed to be unreliable. Main sources of controversies include use of single stages instead of ossification events and diagnostic reliability conjecturally based on correlation analyses. Regarding evidence on the efficiency of functional treatment, when treated during the pubertal growth spurt, more favorable response is seen in skeletal Class II patients even though large individual responsiveness remains. Main sources of controversies include design of clinical trials, definition of Class II malocclusion, and lack of inclusion of skeletal maturity among the prognostic factors. While no growth indicator may be considered to have a full diagnostic reliability in the identification of the pubertal growth spurt, their use may still be recommended for increasing efficiency of functional treatment for skeletal Class II malocclusion. PMID:28168195

Mass and Reliability System (MaRS)

NASA Technical Reports Server (NTRS)

Barnes, Sarah

2016-01-01

The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including: operation hours, random/nonrandom failures, software/hardware failures, quantity, orbital replaceable units (ORU), date of placement, unit weight, frequency of part, etc. The motivation for creating such a database will be the development of a mass/reliability parametric model to estimate mass required for replacement parts. Once complete, engineers working on future space flight missions will have access a mean time to failures and on parts along with their mass, this will be used to make proper decisions for long duration space flight missions

Reliability based design optimization: Formulations and methodologies

NASA Astrophysics Data System (ADS)

Agarwal, Harish

Modern products ranging from simple components to complex systems should be designed to be optimal and reliable. The challenge of modern engineering is to ensure that manufacturing costs are reduced and design cycle times are minimized while achieving requirements for performance and reliability. If the market for the product is competitive, improved quality and reliability can generate very strong competitive advantages. Simulation based design plays an important role in designing almost any kind of automotive, aerospace, and consumer products under these competitive conditions. Single discipline simulations used for analysis are being coupled together to create complex coupled simulation tools. This investigation focuses on the development of efficient and robust methodologies for reliability based design optimization in a simulation based design environment. Original contributions of this research are the development of a novel efficient and robust unilevel methodology for reliability based design optimization, the development of an innovative decoupled reliability based design optimization methodology, the application of homotopy techniques in unilevel reliability based design optimization methodology, and the development of a new framework for reliability based design optimization under epistemic uncertainty. The unilevel methodology for reliability based design optimization is shown to be mathematically equivalent to the traditional nested formulation. Numerical test problems show that the unilevel methodology can reduce computational cost by at least 50% as compared to the nested approach. The decoupled reliability based design optimization methodology is an approximate technique to obtain consistent reliable designs at lesser computational expense. Test problems show that the methodology is computationally efficient compared to the nested approach. A framework for performing reliability based design optimization under epistemic uncertainty is also developed. A trust region managed sequential approximate optimization methodology is employed for this purpose. Results from numerical test studies indicate that the methodology can be used for performing design optimization under severe uncertainty.

Structural integrity of engineering composite materials: a cracking good yarn.

PubMed

Beaumont, Peter W R; Soutis, Costas

2016-07-13

Predicting precisely where a crack will develop in a material under stress and exactly when in time catastrophic fracture of the component will occur is one the oldest unsolved mysteries in the design and building of large-scale engineering structures. Where human life depends upon engineering ingenuity, the burden of testing to prove a 'fracture safe design' is immense. Fitness considerations for long-life implementation of large composite structures include understanding phenomena such as impact, fatigue, creep and stress corrosion cracking that affect reliability, life expectancy and durability of structure. Structural integrity analysis treats the design, the materials used, and figures out how best components and parts can be joined, and takes service duty into account. However, there are conflicting aims in the complete design process of designing simultaneously for high efficiency and safety assurance throughout an economically viable lifetime with an acceptable level of risk. This article is part of the themed issue 'Multiscale modelling of the structural integrity of composite materials'. © 2016 The Author(s).

[Microcystin safety study during Cyanobacteria removal by pressure enhanced coagulation process].

PubMed

Jiang, Xin-Yue; Luan, Qing; Cong, Hai-Bing; Xu, Si-Tao; Liu, Yu-Jiao; Zhu, Xue-Yuan

2014-11-01

Pressure enhanced coagulation and sedimentation technique is an effective way for blue algae treatment. It is not clear whether Cyanobacteria balloon rupture will cause Cyanobacteria cells rupture, resulting in high intracellular concentrations of microcystin LR leak into the water, affecting drinking water safety. Therefore, in this study experimental comparative study of pressure and pre-oxidation of water containing Cyanobacteria was carried out to examine the microcystin LR concentration changes and Cyanobacteria removal efficiency. The results showed that microcystin concentration increase was not significant by the pre-treatment with Cyanobacteria water pressure, while the pre-oxidation process caused a significant increase in the concentration of microcystin. After 0.5-0.8 MPa pressure coagulation and sedimentation, removal of Cyanobacteria basically was over 90%, up to 93.5%, while the removal rate by pre-oxidation was low and unstable. Effluent turbidity is also significantly better in the pre-pressure method than the pre-oxidation. The results indicated that pressure enhanced coagulation is a safe and reliable method for Cyanobacteria removal.

New generation lidar systems for eye safe full time observations

NASA Technical Reports Server (NTRS)

Spinhirne, James D.

1995-01-01

The traditional lidar over the last thirty years has typically been a big pulse low repetition rate system. Pulse energies are in the 0.1 to 1.0 J range and repetition rates from 0.1 to 10 Hz. While such systems have proven to be good research tools, they have a number of limitations that prevent them from moving beyond lidar research to operational, application oriented instruments. These problems include a lack of eye safety, very low efficiency, poor reliability, lack of ruggedness and high development and operating costs. Recent advances in solid state laser, detectors and data systems have enabled the development of a new generation of lidar technology that meets the need for routine, application oriented instruments. In this paper the new approaches to operational lidar systems will be discussed. Micro pulse lidar (MPL) systems are currently in use, and their technology is highlighted. The basis and current development of continuous wave (CW) lidar and potential of other technical approaches is presented.

The Use of Hysterosalpingography in the Diagnosis of Infertility and Other Gynecological Conditions

PubMed Central

Dutton, W. A. W.; Stapleton, J. G.

1963-01-01

Hysterosalpingography was performed on 175 patients who had gynecological symptoms but negative pelvic findings, in order to test a new method of introducing the contrast medium into the uterus and tubes and to record the incidence of pathology revealed. In 132 patients, an attempt was made to secure a No. 14 Foley catheter in the uterus for introducing the contrast medium. This method was successful in 124 patients and can be recommended as being simple, less painful and more efficient than older methods. Of 156 patients with the complaints of infertility (68), dysmenorrhea (31), pelvic pain (29) or menstrual disorder (28), hysterosalpingography revealed significant abnormality in 58; most of these (47) had chronic salpingitis. One flare-up of pelvic inflammation occurred but no other complications were observed. It was concluded that hysterosalpingography is now sufficiently safe and reliable to merit wider utilization in gynecological diagnosis. ImagesFig. 1Fig. 2Fig. 3Fig. 4Fig. 5Fig. 6Fig. 7 PMID:14088822

A prospective study of outcome from rubber band ligation in third degree haemorrhoids.

PubMed

Khan, Asma Niaz; Khan, Naveed Ali

2010-11-01

To evaluate the efficacy and effectiveness of rubber band ligation on 3rd degree haemorrhoids. Study was done at Surgical Unit, Civil Hospital Karachi, during a period of 19 months from December 2006 to July 2008. Out of 344 patients 80 patients were included in the study with 3rd degree internal haemorrhoids and were treated with Rubber band ligation (RBL). Outcome data was recorded for success of treatment. Among 80 patients, 77 (96.25%) were symptom free. After completion of treatment, 1 (16.66%) out of 5 patients had the complaint of pain, 2 (2.85%) out of 70 had complaints of constipation. Before start of treatment 5 (6.25%) patients complained of bleeding per rectum and 73 (91.25%) complained of manually reducible/prolapsed haemorrhoids. Both complaints were cured 100% after treatment. RBL is an efficient, cost-effective and simple out patient procedure for symptomatic third degree haemorrhoids with minimum complications. RBL is a reliable, safe procedure requiring no hospitalization and no use of any anaesthetic drugs.

High-speed civil transport - Advanced flight deck challenges

NASA Technical Reports Server (NTRS)

Swink, Jay R.; Goins, Richard T.

1992-01-01

This paper presents the results of a nine month study of the HSCT flight deck challenges and assessment of its benefits. Operational requirements are discussed and the most significant findings for specified advanced concepts are highlighted. These concepts are a no nose-droop configuration, a far forward cockpit location and advanced crew monitoring and control of complex systems. Results indicate that the no nose-droop configuration is critically dependent on the design and development of a safe, reliable and certifiable synthetic vision system (SVS). This configuration would cause significant weight, performance and cost penalties. A far forward cockpit configuration with a tandem seating arrangement allows either an increase in additional payload or potential downsizing of the vehicle leading to increased performance efficiency and reductions in emissions. The technologies enabling such capabilities, which provide for Category III all-weather opreations on every flight represent a benefit multiplier in a 20005 ATM network in terms of enhanced economic viability and environmental acceptability.

Proton Radiation Therapy in the Hospital Environment: Conception, Development, and Operation of the Initial Hospital-Based Facility

NASA Astrophysics Data System (ADS)

Slater, James M.; Slater, Jerry D.; Wroe, Andrew J.

The world's first hospital-based proton treatment center opened at Loma Linda University Medical Center in 1990, following two decades of development. Patients' needs were the driving force behind its conception, development, and execution; the primary needs were delivery of effective conformal doses of ionizing radiation and avoidance of normal tissue to the maximum extent possible. The facility includes a proton synchrotron and delivery system developed in collaboration with physicists and engineers at Fermi National Accelerator Laboratory and from other high-energy-physics laboratories worldwide. The system, operated and maintained by Loma Linda personnel, was designed to be safe, reliable, flexible in utilization, efficient in use, and upgradeable to meet demands of changing patient needs and advances in technology. Since the facility opened, nearly 14,000 adults and children have been treated for a wide range of cancers and other diseases. Ongoing research is expanding the applications of proton therapy, while reducing costs.

Shuttle Safety Improvements

NASA Technical Reports Server (NTRS)

Henderson, Edward

2001-01-01

The Space Shuttle has been flying for over 20 years and based on the Orbiter design life of 100 missions it should be capable of flying at least 20 years more if we take care of it. The Space Shuttle Development Office established in 1997 has identified those upgrades needed to keep the Shuttle flying safely and efficiently until a new reusable launch vehicle (RLV) is available to meet the agency commitments and goals for human access to space. The upgrade requirements shown in figure 1 are to meet the program goals, support HEDS and next generation space transportation goals while protecting the country 's investment in the Space Shuttle. A major review of the shuttle hardware and processes was conducted in 1999 which identified key shuttle safety improvement priorities, as well as other system upgrades needed to reliably continue to support the shuttle miss ions well into the second decade of this century. The high priority safety upgrades selected for development and study will be addressed in this paper.

Investigation on the forced response of a radial turbine under aerodynamic excitations

NASA Astrophysics Data System (ADS)

Ma, Chaochen; Huang, Zhi; Qi, Mingxu

2016-04-01

Rotor blades in a radial turbine with nozzle guide vanes typically experience harmonic aerodynamic excitations due to the rotor stator interaction. Dynamic stresses induced by the harmonic excitations can result in high cycle fatigue (HCF) of the blades. A reliable prediction method for forced response issue is essential to avoid the HCF problem. In this work, the forced response mechanisms were investigated based on a fluid structure interaction (FSI) method. Aerodynamic excitations were obtained by three-dimensional unsteady computational fluid dynamics (CFD) simulation with phase shifted periodic boundary conditions. The first two harmonic pressures were determined as the primary components of the excitation and applied to finite element (FE) model to conduct the computational structural dynamics (CSD) simulation. The computed results from the harmonic forced response analysis show good agreement with the predictions of Singh's advanced frequency evaluation (SAFE) diagram. Moreover, the mode superposition method used in FE simulation offers an efficient way to provide quantitative assessments of mode response levels and resonant strength.

Diagnostic Reasoning using Prognostic Information for Unmanned Aerial Systems

NASA Technical Reports Server (NTRS)

Schumann, Johann; Roychoudhury, Indranil; Kulkarni, Chetan

2015-01-01

With increasing popularity of unmanned aircraft, continuous monitoring of their systems, software, and health status is becoming more and more important to ensure safe, correct, and efficient operation and fulfillment of missions. The paper presents integration of prognosis models and prognostic information with the R2U2 (REALIZABLE, RESPONSIVE, and UNOBTRUSIVE Unit) monitoring and diagnosis framework. This integration makes available statistically reliable health information predictions of the future at a much earlier time to enable autonomous decision making. The prognostic information can be used in the R2U2 model to improve diagnostic accuracy and enable decisions to be made at the present time to deal with events in the future. This will be an advancement over the current state of the art, where temporal logic observers can only do such valuation at the end of the time interval. Usefulness and effectiveness of this integrated diagnostics and prognostics framework was demonstrated using simulation experiments with the NASA Dragon Eye electric unmanned aircraft.

Software design and implementation concepts for an interoperable medical communication framework.

PubMed

Besting, Andreas; Bürger, Sebastian; Kasparick, Martin; Strathen, Benjamin; Portheine, Frank

2018-02-23

The new IEEE 11073 service-oriented device connectivity (SDC) standard proposals for networked point-of-care and surgical devices constitutes the basis for improved interoperability due to its independence of vendors. To accelerate the distribution of the standard a reference implementation is indispensable. However, the implementation of such a framework has to overcome several non-trivial challenges. First, the high level of complexity of the underlying standard must be reflected in the software design. An efficient implementation has to consider the limited resources of the underlying hardware. Moreover, the frameworks purpose of realizing a distributed system demands a high degree of reliability of the framework itself and its internal mechanisms. Additionally, a framework must provide an easy-to-use and fail-safe application programming interface (API). In this work, we address these challenges by discussing suitable software engineering principles and practical coding guidelines. A descriptive model is developed that identifies key strategies. General feasibility is shown by outlining environments in which our implementation has been utilized.

Structural Health Monitoring for a Z-Type Special Vehicle

PubMed Central

Yuan, Chaolin; Ren, Liang; Li, Hongnan

2017-01-01

Nowadays there exist various kinds of special vehicles designed for some purposes, which are different from regular vehicles in overall dimension and design. In that case, accidents such as overturning will lead to large economical loss and casualties. There are still no technical specifications to follow to ensure the safe operation and driving of these special vehicles. Owing to the poor efficiency of regular maintenance, it is more feasible and effective to apply real-time monitoring during the operation and driving process. In this paper, the fiber Bragg grating (FBG) sensors are used to monitor the safety of a z-type special vehicle. Based on the structural features and force distribution, a reasonable structural health monitoring (SHM) scheme is presented. Comparing the monitoring results with the finite element simulation results guarantees the accuracy and reliability of the monitoring results. Large amounts of data are collected during the operation and driving progress to evaluate the structural safety condition and provide reference for SHM systems developed for other special vehicles. PMID:28587161

A Mathematical Model of Marine Diesel Engine Speed Control System

NASA Astrophysics Data System (ADS)

Sinha, Rajendra Prasad; Balaji, Rajoo

2018-02-01

Diesel engine is inherently an unstable machine and requires a reliable control system to regulate its speed for safe and efficient operation. Also, the diesel engine may operate at fixed or variable speeds depending upon user's needs and accordingly the speed control system should have essential features to fulfil these requirements. This paper proposes a mathematical model of a marine diesel engine speed control system with droop governing function. The mathematical model includes static and dynamic characteristics of the control loop components. Model of static characteristic of the rotating fly weights speed sensing element provides an insight into the speed droop features of the speed controller. Because of big size and large time delay, the turbo charged diesel engine is represented as a first order system or sometimes even simplified to a pure integrator with constant gain which is considered acceptable in control literature. The proposed model is mathematically less complex and quick to use for preliminary analysis of the diesel engine speed controller performance.

Analysis on the University’s Network Security Level System in the Big Data Era

NASA Astrophysics Data System (ADS)

Li, Tianli

2017-12-01

The rapid development of science and technology, the continuous expansion of the scope of computer network applications, has gradually improved the social productive forces, has had a positive impact on the increase production efficiency and industrial scale of China's different industries. Combined with the actual application of computer network in the era of large data, we can see the existence of influencing factors such as network virus, hacker and other attack modes, threatening network security and posing a potential threat to the safe use of computer network in colleges and universities. In view of this unfavorable development situation, universities need to pay attention to the analysis of the situation of large data age, combined with the requirements of network security use, to build a reliable network space security system from the equipment, systems, data and other different levels. To avoid the security risks exist in the network. Based on this, this paper will analyze the hierarchical security system of cyberspace security in the era of large data.

Software Reliability Issues Concerning Large and Safety Critical Software Systems

NASA Technical Reports Server (NTRS)

Kamel, Khaled; Brown, Barbara

1996-01-01

This research was undertaken to provide NASA with a survey of state-of-the-art techniques using in industrial and academia to provide safe, reliable, and maintainable software to drive large systems. Such systems must match the complexity and strict safety requirements of NASA's shuttle system. In particular, the Launch Processing System (LPS) is being considered for replacement. The LPS is responsible for monitoring and commanding the shuttle during test, repair, and launch phases. NASA built this system in the 1970's using mostly hardware techniques to provide for increased reliability, but it did so often using custom-built equipment, which has not been able to keep up with current technologies. This report surveys the major techniques used in industry and academia to ensure reliability in large and critical computer systems.

49 CFR 350.103 - What is the purpose of this part?

Code of Federal Regulations, 2013 CFR

2013-10-01

... motor carrier, CMV, and driver safety to support a safe and efficient transportation system by— (a) Making targeted investments to promote safe CMV transportation, including transportation of passengers... number and severity of CMV crashes and fatalities resulting from such crashes; (c) Adopting and enforcing...

49 CFR 350.103 - What is the purpose of this part?

Code of Federal Regulations, 2014 CFR

2014-10-01

... motor carrier, CMV, and driver safety to support a safe and efficient transportation system by— (a) Making targeted investments to promote safe CMV transportation, including transportation of passengers... number and severity of CMV crashes and fatalities resulting from such crashes; (c) Adopting and enforcing...

How to assess driver's interaction with partially automated driving systems - A framework for early concept assessment.

PubMed

van den Beukel, Arie P; van der Voort, Mascha C

2017-03-01

The introduction of partially automated driving systems changes the driving task into supervising the automation with an occasional need to intervene. To develop interface solutions that adequately support drivers in this new role, this study proposes and evaluates an assessment framework that allows designers to evaluate driver-support within relevant real-world scenarios. Aspects identified as requiring assessment in terms of driver-support within the proposed framework are Accident Avoidance, gained Situation Awareness (SA) and Concept Acceptance. Measurement techniques selected to operationalise these aspects and the associated framework are pilot-tested with twenty-four participants in a driving simulator experiment. The objective of the test is to determine the reliability of the applied measurements for the assessment of the framework and whether the proposed framework is effective in predicting the level of support offered by the concepts. Based on the congruency between measurement scores produced in the test and scores with predefined differences in concept-support, this study demonstrates the framework's reliability. A remaining concern is the framework's weak sensitivity to small differences in offered support. The article concludes that applying the framework is especially advantageous for evaluating early design phases and can successfully contribute to the efficient development of driver's in-control and safe means of operating partially automated vehicles. Copyright © 2016 Elsevier Ltd. All rights reserved.

Assessment of owner-directed aggressive behavioural tendencies of dogs in situations of possession and manipulation

PubMed Central

Bálint, Anna; Rieger, Gabriella; Miklósi, Ádám

2017-01-01

Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually different behavioural tests: ‘take away bone’ and ‘roll over’. Based on dogs' behaviour in the tests, we sorted dogs (N = 93) in two groups for each test, namely a less and a more disobedient/resistant group. The two principal components obtained in our questionnaire—‘obedient’ and ‘aggressive towards owner’—showed significant differences between the behaviour groups. While dogs in the less disobedient/resistant groups had significantly higher ‘obedient’ and significantly lower ‘aggressive towards owner’ scores, dogs in the more disobedient/resistant groups had significantly higher ‘aggressive towards owner’ and significantly lower ‘obedient’ scores. Dogs' age, sex and neuter/spay status expressed their effect through interactions. Males, young dogs and intact dogs were less ‘obedient’ than older ones, while resistant spayed/neutered dogs were more aggressive towards the owner. The questionnaire used is a safe, easy to deploy and time-efficient tool to reliably assess certain owner-directed aggressive tendencies of family dogs. PMID:29134099

Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma.

PubMed

Mir, Olivier; Ropert, Stanislas; Babinet, Antoine; Alexandre, Jérôme; Larousserie, Frédérique; Durand, Jean-Philippe; Enkaoua, Eric; Anract, Philippe; Goldwasser, François

2010-11-01

To evaluate the reliability and renal safety of an original schedule of high-dose methotrexate (HDMTX) administration with hyper-alkalinization, and without hyper-hydration. Patients with osteosarcoma received HDMTX (8-12 g/m(2)) as a 4-h infusion. Hypertonic 8.4% sodium bicarbonate was infused prior to HDMTX, then once daily for 3 days. Methotrexate serum concentrations were measured at hour 4 (Cmax), hour 24, hour 48, and hour 72. Urinary pH was measured on each miction. Serum creatinine was assessed on days 1, 3, and 8. Twenty-six patients (median age: 18 years, range: 15-25) received a total of 344 cycles of HDMTX, including 16 patients treated in an outpatient basis. Urinary pH remained constantly higher than 7.5 in all patients. Grade 1 creatininemia toxicity was observed in 31 cycles (9%), and grade 2 creatinine toxicity was observed in one patient. No episode of acute severe nephrotoxicity was observed. No significant worsening was observed in serum creatinine and calculated creatinine clearance from baseline to the end of therapy (P = 0.74). The main extra-renal toxicity was alkalinization-related hypokalemia from H48. No re-hospitalization was required. Hyper-alkalinization appears an efficient and reliable method to prevent the acute renal toxicity of HDMTX and allows its safe administration in the outpatient setting.

Pennsylvania Village to Get Safe, Reliable Water Supply

EPA Pesticide Factsheets

A Pennsylvania village whose unfiltered, contaminated water source made it the top violator of federal and state drinking water laws will be connected to a public water system in 2015 with $2.2 million from EPA’s Drinking Water State Revolving Fund

Performance Measures of Warm Asphalt Mixtures for Safe and Reliable Freight Transportation

DOT National Transportation Integrated Search

2009-04-01

Warm mix asphalt (WMA) is an emerging technology that can allow asphalt to flow at a lower temperature for mixing, placing and compaction. The advantages of WMA include reduced fuel consumption, less carbon dioxide emission, longer paving season, lon...

Redundant electronic circuit provides fail-safe control

NASA Technical Reports Server (NTRS)

Archer, J. W.

1970-01-01

Circuit using dual control amplifiers and dual position demand potentiometers powered from separate sources is used for reliable hydraulic valve controller that prevents closure of valve when control circuits fail, and maintains valve control to close tolerance for more common modes of controller failure.

NASA Applications and Lessons Learned in Reliability Engineering

NASA Technical Reports Server (NTRS)

Safie, Fayssal M.; Fuller, Raymond P.

2011-01-01

Since the Shuttle Challenger accident in 1986, communities across NASA have been developing and extensively using quantitative reliability and risk assessment methods in their decision making process. This paper discusses several reliability engineering applications that NASA has used over the year to support the design, development, and operation of critical space flight hardware. Specifically, the paper discusses several reliability engineering applications used by NASA in areas such as risk management, inspection policies, components upgrades, reliability growth, integrated failure analysis, and physics based probabilistic engineering analysis. In each of these areas, the paper provides a brief discussion of a case study to demonstrate the value added and the criticality of reliability engineering in supporting NASA project and program decisions to fly safely. Examples of these case studies discussed are reliability based life limit extension of Shuttle Space Main Engine (SSME) hardware, Reliability based inspection policies for Auxiliary Power Unit (APU) turbine disc, probabilistic structural engineering analysis for reliability prediction of the SSME alternate turbo-pump development, impact of ET foam reliability on the Space Shuttle System risk, and reliability based Space Shuttle upgrade for safety. Special attention is given in this paper to the physics based probabilistic engineering analysis applications and their critical role in evaluating the reliability of NASA development hardware including their potential use in a research and technology development environment.

Bioreducible Fluorinated Peptide Dendrimers Capable of Circumventing Various Physiological Barriers for Highly Efficient and Safe Gene Delivery.

PubMed

Cai, Xiaojun; Jin, Rongrong; Wang, Jiali; Yue, Dong; Jiang, Qian; Wu, Yao; Gu, Zhongwei

2016-03-09

Polymeric vectors have shown great promise in the development of safe and efficient gene delivery systems; however, only a few have been developed in clinical settings due to poor transport across multiple physiological barriers. To address this issue and promote clinical translocation of polymeric vectors, a new type of polymeric vector, bioreducible fluorinated peptide dendrimers (BFPDs), was designed and synthesized by reversible cross-linking of fluorinated low generation peptide dendrimers. Through masterly integration all of the features of reversible cross-linking, fluorination, and polyhedral oligomeric silsesquioxane (POSS) core-based peptide dendrimers, this novel vector exhibited lots of unique features, including (i) inactive surface to resist protein interactions; (ii) virus-mimicking surface topography to augment cellular uptake; (iii) fluorination-mediated efficient cellular uptake, endosome escape, cytoplasm trafficking, and nuclear entry, and (iv) disulfide-cleavage-mediated polyplex disassembly and DNA release that allows efficient DNA transcription. Noteworthy, all of these features are functionally important and can synergistically facilitate DNA transport from solution to the nucleus. As a consequences, BFPDs showed excellent gene transfection efficiency in several cell lines (∼95% in HEK293 cells) and superior biocompatibility compared with polyethylenimine (PEI). Meanwhile BFPDs provided excellent serum resistance in gene delivery. More importantly, BFPDs offer considerable in vivo gene transfection efficiency (in muscular tissues and in HepG2 tumor xenografts), which was approximately 77-fold higher than that of PEI in luciferase activity. These results suggest bioreducible fluorinated peptide dendrimers are a new class of highly efficient and safe gene delivery vectors and should be used in clinical settings.

Sea sand disruption method (SSDM) as a valuable tool for isolating essential oil components from conifers.

PubMed

Dawidowicz, Andrzej L; Czapczyńska, Natalia B

2011-11-01

Essential oils are one of nature's most precious gifts with surprisingly potent and outstanding properties. Coniferous oils, for instance, are nowadays being used extensively to treat or prevent many types of infections, modify immune responses, soothe inflammations, stabilize moods, and to help ease all forms of non-acute pain. Given the broad spectrum of usage of coniferous essential oils, a fast, safe, simple, and efficient sample-preparation method is needed in the estimation procedure of essential oil components in fresh plant material. Generally, the time- and energy-consuming steam distillation (SD) is applied for this purpose. This paper will compare SD, pressurized liquid extraction (PLE), matrix solid-phase dispersion (MSPD), and the sea sand disruption method (SSDM) as isolation techniques to obtain aroma components from Scots pine (Pinus sylvestris), spruce (Picea abies), and Douglas fir (Pseudotsuga menziesii). According to the obtained data, SSDM is the most efficient sample preparation method in determining the essential oil composition of conifers. Moreover, SSDM requires small organic solvent amounts and a short extraction time, which makes it an advantageous alternative procedure for the routine analysis of coniferous oils. The superiority of SSDM over MSPD efficiency is ascertained, as there are no chemical interactions between the plant cell components and the sand. This fact confirms the reliability and efficacy of SSDM for the analysis of volatile oil components. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.

Rollover risk prediction of heavy vehicles by reliability index and empirical modelling

NASA Astrophysics Data System (ADS)

Sellami, Yamine; Imine, Hocine; Boubezoul, Abderrahmane; Cadiou, Jean-Charles

2018-03-01

This paper focuses on a combination of a reliability-based approach and an empirical modelling approach for rollover risk assessment of heavy vehicles. A reliability-based warning system is developed to alert the driver to a potential rollover before entering into a bend. The idea behind the proposed methodology is to estimate the rollover risk by the probability that the vehicle load transfer ratio (LTR) exceeds a critical threshold. Accordingly, a so-called reliability index may be used as a measure to assess the vehicle safe functioning. In the reliability method, computing the maximum of LTR requires to predict the vehicle dynamics over the bend which can be in some cases an intractable problem or time-consuming. With the aim of improving the reliability computation time, an empirical model is developed to substitute the vehicle dynamics and rollover models. This is done by using the SVM (Support Vector Machines) algorithm. The preliminary obtained results demonstrate the effectiveness of the proposed approach.

Validity of instruments to assess students' travel and pedestrian safety.

PubMed

Mendoza, Jason A; Watson, Kathy; Baranowski, Tom; Nicklas, Theresa A; Uscanga, Doris K; Hanfling, Marcus J

2010-05-18

Safe Routes to School (SRTS) programs are designed to make walking and bicycling to school safe and accessible for children. Despite their growing popularity, few validated measures exist for assessing important outcomes such as type of student transport or pedestrian safety behaviors. This research validated the SRTS school travel survey and a pedestrian safety behavior checklist. Fourth grade students completed a brief written survey on how they got to school that day with set responses. Test-retest reliability was obtained 3-4 hours apart. Convergent validity of the SRTS travel survey was assessed by comparison to parents' report. For the measure of pedestrian safety behavior, 10 research assistants observed 29 students at a school intersection for completion of 8 selected pedestrian safety behaviors. Reliability was determined in two ways: correlations between the research assistants' ratings to that of the Principal Investigator (PI) and intraclass correlations (ICC) across research assistant ratings. The SRTS travel survey had high test-retest reliability (kappa = 0.97, n = 96, p < 0.001) and convergent validity (kappa = 0.87, n = 81, p < 0.001). The pedestrian safety behavior checklist had moderate reliability across research assistants' ratings (ICC = 0.48) and moderate correlation with the PI (r = 0.55, p = < 0.01). When two raters simultaneously used the instrument, the ICC increased to 0.65. Overall percent agreement (91%), sensitivity (85%) and specificity (83%) were acceptable. These validated instruments can be used to assess SRTS programs. The pedestrian safety behavior checklist may benefit from further formative work.

Energy Storage | Transportation Research | NREL

Science.gov Websites

, and safe energy storage systems to power the next generation of electric-drive vehicles (EDVs). While lasting, safe, and operate at maximum efficiency in a wide range of driving conditions and climates. The Consumers, Industry, and the Environment As manufacturers develop new electric-drive vehicles, NREL acts as

Compliant Task Execution and Learning for Safe Mixed-Initiative Human-Robot Operations

NASA Technical Reports Server (NTRS)

Dong, Shuonan; Conrad, Patrick R.; Shah, Julie A.; Williams, Brian C.; Mittman, David S.; Ingham, Michel D.; Verma, Vandana

2011-01-01

We introduce a novel task execution capability that enhances the ability of in-situ crew members to function independently from Earth by enabling safe and efficient interaction with automated systems. This task execution capability provides the ability to (1) map goal-directed commands from humans into safe, compliant, automated actions, (2) quickly and safely respond to human commands and actions during task execution, and (3) specify complex motions through teaching by demonstration. Our results are applicable to future surface robotic systems, and we have demonstrated these capabilities on JPL's All-Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE) robot.

A testing-coverage software reliability model considering fault removal efficiency and error generation

PubMed Central

Li, Qiuying; Pham, Hoang

2017-01-01

In this paper, we propose a software reliability model that considers not only error generation but also fault removal efficiency combined with testing coverage information based on a nonhomogeneous Poisson process (NHPP). During the past four decades, many software reliability growth models (SRGMs) based on NHPP have been proposed to estimate the software reliability measures, most of which have the same following agreements: 1) it is a common phenomenon that during the testing phase, the fault detection rate always changes; 2) as a result of imperfect debugging, fault removal has been related to a fault re-introduction rate. But there are few SRGMs in the literature that differentiate between fault detection and fault removal, i.e. they seldom consider the imperfect fault removal efficiency. But in practical software developing process, fault removal efficiency cannot always be perfect, i.e. the failures detected might not be removed completely and the original faults might still exist and new faults might be introduced meanwhile, which is referred to as imperfect debugging phenomenon. In this study, a model aiming to incorporate fault introduction rate, fault removal efficiency and testing coverage into software reliability evaluation is developed, using testing coverage to express the fault detection rate and using fault removal efficiency to consider the fault repair. We compare the performance of the proposed model with several existing NHPP SRGMs using three sets of real failure data based on five criteria. The results exhibit that the model can give a better fitting and predictive performance. PMID:28750091

Is transverse acetabular ligament an anatomical landmark to reliably orient the cup in primary total hip arthroplasty?

PubMed

Viste, A; Chouteau, J; Testa, R; Chèze, L; Fessy, M-H; Moyen, B

2011-05-01

Accurate positioning of the acetabular cup in primary total hip arthroplasty is critical to decrease the rate of dislocation. Inaccurate orientation of the cup is the most common error during this procedure. Target acetabular orientation is still controversial. An original study found a dislocation rate of 0.6% when the cup was aligned with the transverse acetabular ligament (TAL). TAL is a patient-specific anatomical landmark and a tool for cup orientation. Eight cadaveric pelves (14 hips included for study) were harvested in toto at our research laboratory. Anatomical versions of the TAL, labrum and horns were measured in relation to the anterior pelvic plane. A navigator sensor and an optoelectronic device (Motion Analysis™) were used. Anatomical versions of the TAL, horns and labrum averaged 1.9° (range, -8° to +13.3°), 3° (range, -12.2° to 14°), and 26.3° (range, 17.4° to 41.8°), respectively. To our knowledge, this is the first study to report the orientation of the periacetabular soft-tissues. TAL anteversion was outside the safe zone described by Lewinnek, while labrum anteversion was within this safe-zone. We discuss the reference used, Lewinnek's safe zone, and functional orientation of the implants. Lewinnek's safe-zone does not seem to be valid. The TAL seems to be a specific reference for each patient but its reliability must still be confirmed as an adequate reference for positioning the cup in total hip arthroplasty. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Driver Education Curriculum Guide. Energy Conservation.

ERIC Educational Resources Information Center

Governor's Highway Safety Program Office, Columbus, OH.

Designed to provide high school students with information concerning energy-efficient driving, this curriculum guide covers techniques of conserving energy, efficient use of motor vehicles, safe driving techniques, and development of energy-efficient driving habits. The guide consists of six lessons: (1) Fuel Conservation: Why It Is Essential; (2)…

77 FR 29897 - Drawbridge Operation Regulation; Willamette River, Portland, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... Portland, OR. This deviation is necessary to accommodate the efficient movement of light rail and roadway... the Steel Bridge to remain in the closed position to facilitate efficient movement of event patrons... Steel Bridge remain closed to vessel traffic to facilitate safe efficient movement of light rail and...

Adaptation, translation and reliability of the Australian 'Juniors Enjoying Cricket Safely' injury risk perception questionnaire for Sri Lanka.

PubMed

Gamage, Prasanna J; Fortington, Lauren V; Finch, Caroline F

2018-01-01

Cricket is a very popular sport in Sri Lanka. In this setting there has been limited research; specifically, there is little knowledge of cricket injuries. To support future research possibilities, the aim of this study was to cross-culturally adapt, translate and test the reliability of an Australian-developed questionnaire for the Sri Lankan context. The Australian 'Juniors Enjoying Cricket Safely' (JECS-Aus) injury risk perception questionnaire was cross-culturally adapted to suit the Sri Lankan context and subsequently translated into the two main languages (Sinhala and Tamil) based on standard forward-back translation. The translated questionnaires were examined for content validity by two language schoolteachers. The questionnaires were completed twice, 2 weeks apart, by two groups of school cricketers (males) aged 11-15 years (Sinhala (n=24), Tamil (n=30)) to assess reliability. Test-retest scores were evaluated for agreement. Where responses were <100% agreement, Cohen's kappa (κ) statistics were calculated. Questions with moderate-to-poor test-retest reliability (κ<0.6) were reconsidered for modification. Both the Sinhala and Tamil questionnaires had 100% agreement for questions on demographic data, and 88%-100% agreement for questions on participation in cricket and injury history. Of the injury risk perception questions, 72% (Sinhala) and 90% (Tamil) questions showed a substantial (κ=0.61-0.8) and almost perfect (κ=0.81-1.0) test-retest agreement. The adapted and translated JECS-SL questionnaire demonstrated strong reliability. This is the first study to adapt the JECS-Aus questionnaire for use in a different population, providing an outcome measure for assessing injury risk perceptions in Sri Lankan junior cricketers.

Anatomical Basis for Safe and Effective Volumization of the Temple.

PubMed

Breithaupt, Andrew D; Jones, Derek H; Braz, Andre; Narins, Rhoda; Weinkle, Susan

2015-12-01

One of the earliest but often unaddressed signs of facial aging is volume loss in the temple. Treatment of the area can produce satisfying results for both patient and practitioner. Safe injection requires explicit knowledge of the anatomy to avoid complications related to the multitude of vessels that course throughout the region at various depths. The authors aim to detail the anatomy of the area and provide a safe and easy-to-follow method for injection. The authors review the relevant anatomy of the temporal region and its application to cosmetic filler injections. The authors describe an easy-to-follow approach for a safe and effective injection window based on numerous anatomical studies. Injection in this area is not without risk, including potential blindness. The authors review the potential complications and their treatments. Hollowing of the temple is an early sign of aging that, when corrected, can lead to significant patient and practitioner satisfaction. Proper anatomically knowledge is required to avoid potentially severe complications. In this study, the authors present a reliable technique to safely and effectively augment this often undertreated area of the aging face.

Non-contact optical Liquid Level Sensors

NASA Astrophysics Data System (ADS)

Kiseleva, L. L.; Tevelev, L. V.; Shaimukhametov, R. R.

2016-06-01

Information about characteristics of the optical liquid level sensor are present. Sensors are used to control of the light level limit fluid - water, kerosene, alcohol, solutions, etc. Intrinsically safe, reliable and easy to use. The operating principle of the level sensor is an optoelectronic infrared device.

Effect of Ethanol Blends and Batching Operations on SCC of Carbon Steel

DOT National Transportation Integrated Search

2011-02-08

This is the draft final report of the project on blending and batching (WP#325) of the Consolidated Program on Development of Guidelines for Safe and Reliable Pipeline Transportation of Ethanol Blends. The other two aspects of the consolidated progra...

Transit climate change adaptation assessment/asset management pilot for the Metropolitan Atlanta Rapid Transit Authority.

DOT National Transportation Integrated Search

2013-08-01

Public transit agencies play an important role in the provision of safe, reliable, and cost-effective transportation for the communities they serve. With the growing intensity and frequency of extreme weather events, such as hurricanes Irene and Sand...

Verification Methodology of Fault-tolerant, Fail-safe Computers Applied to MAGLEV Control Computer Systems

DOT National Transportation Integrated Search

1993-05-01

The Maglev control computer system should be designed to verifiably possess high reliability and safety as well as high availability to make Maglev a dependable and attractive transportation alternative to the public. A Maglev computer system has bee...

Some Characteristics of One Type of High Reliability Organization.

ERIC Educational Resources Information Center

Roberts, Karlene H.

1990-01-01

Attempts to define organizational processes necessary to operate safely technologically complex organizations. Identifies nuclear powered aircraft carriers as examples of potentially hazardous organizations with histories of excellent operations. Discusses how carriers deal with components of risk and antecedents to catastrophe cited by Perrow and…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goodwin, Malik

Reliable public lighting remains a critically important and valuable public service in Detroit, Michigan. The Downtown Detroit Energy Efficiency Lighting Program (the, “Program”) was designed and implemented to bring the latest advancements in lighting technology, energy efficiency, public safety and reliability to Detroit’s Central Business District, and the Program accomplished those goals successfully. Downtown’s nighttime atmosphere has been upgraded as a result of the installation of over 1000 new LED roadway lighting fixtures that were installed as part of the Program. The reliability of the lighting system has also improved.

Landowner’s Guide for Compatible Use of BPA Rights-of-Way

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Keeping transmission lines safe and reliable is a critical priority for the Bonneville Power Administration. The key element in achieving those objectives is BPA’s ability to construct, operate and maintain its transmission lines and rights-of-way — the area under and around the lines. You can help BPA keep these rights-of-way clear of trees, brush and structures that could affect the safety or reliability of the transmission system. Prior to planting, digging, or constructing within BPA’s rights-of-way, fill out BPA’s Land Use Application Form. The information you provide on the application helps BPA understand your proposed use and the potential impactsmore » to public safety, and the safety of our crews. BPA also reviews the application to determine whether a proposed use of land is compatible with the construction, operation and maintenance of BPA transmission lines. Coordinating with BPA early in your planning process can keep you safe and avoid wasting time and money.« less

Post-traumatic orbital reconstruction: anatomical landmarks and the concept of the deep orbit.

PubMed

Evans, B T; Webb, A A C

2007-04-01

Dissection deep within the orbit is a cause for concern to surgeons because of the perceived risks of injuring critical structures such as the contents of the superior orbital fissure and the optic nerve. Although "safe distances" (those distances within which it is considered safe to dissect within the orbit) have been described, these are of limited value if the orbit is severely disrupted or is congenitally shallow. In addition, traumatic defects in the orbital floor, in particular, often extend beyond these distances. Reliable landmarks based on the relations between anatomical structures within the orbit, rather than absolute distances, are described that permit safe dissection within the orbit. We present the concept of the deep orbit and describe its relevance to repair of injuries.

Population-based study of intra-household gender differences in water insecurity: reliability and validity of a survey instrument for use in rural Uganda.

PubMed

Tsai, Alexander C; Kakuhikire, Bernard; Mushavi, Rumbidzai; Vořechovská, Dagmar; Perkins, Jessica M; McDonough, Amy Q; Bangsberg, David R

2016-04-01

Hundreds of millions of people worldwide lack adequate access to water. Water insecurity, which is defined as having limited or uncertain availability of safe water or the ability to acquire safe water in socially acceptable ways, is typically overlooked by development organizations focusing on water availability. To address the urgent need in the literature for validated measures of water insecurity, we conducted a population-based study in rural Uganda with 327 reproductive-age women and 204 linked men from the same households. We used a novel method of photo identification so that we could accurately elicit study participants' primary household water sources, thereby enabling us to identify water sources for objective water quality testing and distance/elevation measurement. Our psychometric analyses provided strong evidence of the internal structure, reliability, and validity of a new eight-item Household Water Insecurity Access Scale (HWIAS). Important intra-household gender differences in perceptions of water insecurity were observed, with men generally perceiving household water insecurity as being less severe compared to women. In summary, the HWIAS represents a reliable and valid measure of water insecurity, particularly among women, and may be useful for informing and evaluating interventions to improve water access in resource-limited settings.

Population-Based Study of Intra-Household Gender Differences in Water Insecurity: Reliability and Validity of a Survey Instrument for Use in Rural Uganda

PubMed Central

Tsai, Alexander C.; Kakuhikire, Bernard; Mushavi, Rumbidzai; Vořechovská, Dagmar; Perkins, Jessica M.; McDonough, Amy Q.; Bangsberg, David R.

2015-01-01

Hundreds of millions of persons worldwide lack adequate access to water. Water insecurity, which is defined as having limited or uncertain availability of safe water or the ability to acquire safe water in socially acceptable ways, is typically overlooked by development organizations focusing on water availability. To address the urgent need in the literature for validated measures of water insecurity, we conducted a population-based study in rural Uganda with 327 reproductive-age women and 204 linked men from the same households. We used a novel method of photo identification so that we could accurately elicit study participants’ primary household water sources, thereby enabling us to identify water sources for objective water quality testing and distance/elevation measurement. Our psychometric analyses provided strong evidence of the internal structure, reliability, and validity of a new 8-item Household Water Insecurity Access Scale. Important intra-household gender differences in perceptions of water insecurity were observed, with men generally perceiving household water insecurity as being less severe compared to women. In summary, the Household Water Insecurity Access Scale represents a reliable and valid measure of water insecurity, particularly among women, and may be useful for informing and evaluating interventions to improve water access in resource limited settings. PMID:27105413

Agreement between physicians' and nurses' clinical decisions for the management of the fracture liaison service (4iFLS): the Lucky Bone™ program.

PubMed

Senay, A; Delisle, J; Raynauld, J P; Morin, S N; Fernandes, J C

2016-04-01

We determined if nurses can manage osteoporotic fractures in a fracture liaison service by asking a rheumatologist and an internist to assess their clinical decisions. Experts agreed on more than 94 % of all nurses' actions for 525 fragility fracture patients, showing that their management is efficient and safe. A major care gap exists in the investigation of bone fragility and initiation of treatment for individuals who have sustained a fragility fracture. The implementation of a fracture liaison service (FLS) managed by nurses could be the key in resolving this problem. The aim of this project was to obtain agreement between physicians' and nurses' clinical decisions and evaluate if the algorithm of care is efficient and reliable for the management of a FLS. Clinical decisions of nurses for 525 subjects in a fracture liaison service between 2010 and 2013 were assessed by two independent physicians with expertise in osteoporosis treatment. Nurses succeeded in identifying all patients at risk and needed to refer 27 % of patients to an MD. Thereby, they managed autonomously 73 % of fragility fracture patients. No needless referrals were made according to assessing physicians. Agreement between each evaluator and nurses was of >97 %. Physicians' decisions were the same in >96 %, and Gwet AC11 coefficient was of >0.960 (almost perfect level of agreement). All major comorbidities were adequately managed. High agreement between nurses' and physicians' clinical decisions indicate that the independent management by nurses of a fracture liaison service is safe and should strongly be recommended in the care of patients with a fragility fracture. This kind of intervention could help resolve the existing care gap in bone fragility care as well as the societal economic burden associated with prevention and treatment of fragility fractures.

The Rorschach Perceptual-Thinking Index (PTI): An Examination of Reliability, Validity, and Diagnostic Efficiency

ERIC Educational Resources Information Center

Hilsenroth, Mark J.; Eudell-Simmons, Erin M.; DeFife, Jared A.; Charnas, Jocelyn W.

2007-01-01

This study investigates the reliability, validity, and diagnostic efficiency of the Rorschach Perceptual-Thinking Index (PTI) in relation to the accurate identification of psychotic disorder (PTD) patients. The PTI is a revision of the Rorschach Schizophrenia Index (SCZI), designed to achieve several criteria, including an increase in the…

Framework to evaluate the worth of hydraulic conductivity data for optimal groundwater resources management in ecologically sensitive areas

NASA Astrophysics Data System (ADS)

Feyen, Luc; Gorelick, Steven M.

2005-03-01

We propose a framework that combines simulation optimization with Bayesian decision analysis to evaluate the worth of hydraulic conductivity data for optimal groundwater resources management in ecologically sensitive areas. A stochastic simulation optimization management model is employed to plan regionally distributed groundwater pumping while preserving the hydroecological balance in wetland areas. Because predictions made by an aquifer model are uncertain, groundwater supply systems operate below maximum yield. Collecting data from the groundwater system can potentially reduce predictive uncertainty and increase safe water production. The price paid for improvement in water management is the cost of collecting the additional data. Efficient data collection using Bayesian decision analysis proceeds in three stages: (1) The prior analysis determines the optimal pumping scheme and profit from water sales on the basis of known information. (2) The preposterior analysis estimates the optimal measurement locations and evaluates whether each sequential measurement will be cost-effective before it is taken. (3) The posterior analysis then revises the prior optimal pumping scheme and consequent profit, given the new information. Stochastic simulation optimization employing a multiple-realization approach is used to determine the optimal pumping scheme in each of the three stages. The cost of new data must not exceed the expected increase in benefit obtained in optimal groundwater exploitation. An example based on groundwater management practices in Florida aimed at wetland protection showed that the cost of data collection more than paid for itself by enabling a safe and reliable increase in production.

A quick, easy, cheap, effective, rugged, and safe method for the simultaneous detection of four triazolone herbicides in cereals combined with ultrahigh performance liquid chromatography with tandem mass spectrometry.

PubMed

Tao, Yan; Xu, Jun; Liu, Xingang; Cheng, Youpu; Liu, Na; Chen, Zenglong; Dong, Fengshou; Zheng, Yonguan

2014-09-01

This paper describes a novel, rapid, and sensitive analytical method for monitoring four triazolone herbicides in cereals (wheat, rice, corn, and soybean), using a quick, easy, cheap, effective, rugged, and safe sample extraction procedure followed by ultrahigh performance liquid chromatography coupled with tandem mass spectrometry. The four triazolone herbicides (amicarbazone, carfentrazone-ethyl, sulfentrazone, and thiencarbazone-methyl) were extracted using acidified acetonitrile (containing 1% v/v formic acid) and subsequently purified with octadecylsilane (C18 ) prior to sample analysis. Ultrahigh performance liquid chromatography coupled with tandem mass spectrometry was operated in positive and negative ionization switching mode. Amicarbazone and carfentrazone-ethyl were detected in the positive mode (ESI+), while sulfentrazone and thiencarbazone-methyl were detected in the negative mode (ESI-). All compounds were successfully separated in less than 3.0 min. Further optimization achieved desired recoveries ranging from 74.5 to 102.1% for all analytes with relative standard deviation values ≤17.2% in all tested matrices at three levels (10, 100, and 500 μg/kg). The limits of detection for all compounds were ≤2.3 μg/kg, and the limits of quantitation did not exceed 7.1 μg/kg. The developed method showed excellent linearity (R(2) ≥ 0.994) and was proven to be highly efficient and reliable for the routine monitoring of triazolone herbicides in cereals. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Material Selection for Cable Gland to Improved Reliability of the High-hazard Industries

NASA Astrophysics Data System (ADS)

Vashchuk, S. P.; Slobodyan, S. M.; Deeva, V. S.; Vashchuk, D. S.

2018-01-01

The sealed cable glands (SCG) are available to ensure safest connection sheathed single wire for the hazard production facility (nuclear power plant and others) the same as pilot cable, control cables, radio-frequency cables et al. In this paper, we investigate the specifics of the material selection of SCG with the express aim of hazardous man-made facility. We discuss the safe working conditions for cable glands. The research indicates the sintering powdered metals cables provide the reliability growth due to their properties. A number of studies have demonstrated the verification of material selection. On the face of it, we make findings indicating that double glazed sealed units could enhance reliability. We had evaluated sample reliability under fire conditions, seismic load, and pressure containment failure. We used the samples mineral insulated thermocouple cable.

Maximizing Efficiency and Reducing Robotic Surgery Costs Using the NASA Task Load Index.

PubMed

Walters, Carrie; Webb, Paula J

2017-10-01

Perioperative leaders at our facility were struggling to meet efficiency targets for robotic surgery procedures while also maintaining the satisfaction of the surgical team. We developed a human resources time and motion study tool and used it in conjunction with the NASA Task Load Index to observe and analyze the required workload of personnel assigned to 25 robotic surgery procedures. The time and motion study identified opportunities to enlist the help of nonlicensed support personnel to ensure safe patient care and improve OR efficiency. Using the NASA Task Load Index demonstrated that high temporal, effort, and physical demands existed for personnel assisting with and performing robotic surgery. We believe that this process could be used to develop cost-effective staffing models, resulting in safe and efficient care for all surgical patients. Copyright © 2017 AORN, Inc. Published by Elsevier Inc. All rights reserved.

Ultracapacitor-Based Uninterrupted Power Supply System

NASA Technical Reports Server (NTRS)

Eichenberg, Dennis J.

2011-01-01

The ultracapacitor-based uninterrupted power supply (UPS) system enhances system reliability; reduces life-of-system, maintenance, and downtime costs; and greatly reduces environmental impact when compared to conventional UPS energy storage systems. This design provides power when required and absorbs power when required to smooth the system load and also has excellent low-temperature performance. The UPS used during hardware tests at Glenn is an efficient, compact, maintenance-free, rack-mount, pure sine-wave inverter unit. The UPS provides a continuous output power up to 1,700 W with a surge rating of 1,870 W for up to one minute at a nominal output voltage of 115 VAC. The ultracapacitor energy storage system tested in conjunction with the UPS is rated at 5.8 F. This is a bank of ten symmetric ultracapacitor modules. Each module is actively balanced using a linear voltage balancing technique in which the cell-to-cell leakage is dependent upon the imbalance of the individual cells. The ultracapacitors are charged by a DC power supply, which can provide up to 300 VDC at 4 A. A constant-voltage, constant-current power supply was selected for this application. The long life of ultracapacitors greatly enhances system reliability, which is significant in critical applications such as medical power systems and space power systems. The energy storage system can usually last longer than the application, given its 20-year life span. This means that the ultracapacitors will probably never need to be replaced and disposed of, whereas batteries require frequent replacement and disposal. The charge-discharge efficiency of rechargeable batteries is approximately 50 percent, and after some hundreds of charges and discharges, they must be replaced. The charge-discharge efficiency of ultracapacitors exceeds 90 percent, and can accept more than a million charges and discharges. Thus, there is a significant energy savings through the efficiency improvement, and there is far less downtime for applications and labor involved in replacing an ultracapacitor versus batteries. Also, the lengthy lifespan of this design would greatly reduce the disposal problems posed by lead acid, nickel cadmium, lithium, and nickel metal hydride batteries. This innovation is recyclable by nature, which further reduces system costs. The disposal of ultracapacitors is simple, as they are constructed of non-hazardous components. They are also safer than batteries in that they can be easily discharged, and left indefinitely in a safe, discharged state where batteries cannot.

Fundamentals of endoscopic surgery: creation and validation of the hands-on test.

PubMed

Vassiliou, Melina C; Dunkin, Brian J; Fried, Gerald M; Mellinger, John D; Trus, Thadeus; Kaneva, Pepa; Lyons, Calvin; Korndorffer, James R; Ujiki, Michael; Velanovich, Vic; Kochman, Michael L; Tsuda, Shawn; Martinez, Jose; Scott, Daniel J; Korus, Gary; Park, Adrian; Marks, Jeffrey M

2014-03-01

The Fundamentals of Endoscopic Surgery™ (FES) program consists of online materials and didactic and skills-based tests. All components were designed to measure the skills and knowledge required to perform safe flexible endoscopy. The purpose of this multicenter study was to evaluate the reliability and validity of the hands-on component of the FES examination, and to establish the pass score. Expert endoscopists identified the critical skill set required for flexible endoscopy. They were then modeled in a virtual reality simulator (GI Mentor™ II, Simbionix™ Ltd., Airport City, Israel) to create five tasks and metrics. Scores were designed to measure both speed and precision. Validity evidence was assessed by correlating performance with self-reported endoscopic experience (surgeons and gastroenterologists [GIs]). Internal consistency of each test task was assessed using Cronbach's alpha. Test-retest reliability was determined by having the same participant perform the test a second time and comparing their scores. Passing scores were determined by a contrasting groups methodology and use of receiver operating characteristic curves. A total of 160 participants (17 % GIs) performed the simulator test. Scores on the five tasks showed good internal consistency reliability and all had significant correlations with endoscopic experience. Total FES scores correlated 0.73, with participants' level of endoscopic experience providing evidence of their validity, and their internal consistency reliability (Cronbach's alpha) was 0.82. Test-retest reliability was assessed in 11 participants, and the intraclass correlation was 0.85. The passing score was determined and is estimated to have a sensitivity (true positive rate) of 0.81 and a 1-specificity (false positive rate) of 0.21. The FES hands-on skills test examines the basic procedural components required to perform safe flexible endoscopy. It meets rigorous standards of reliability and validity required for high-stakes examinations, and, together with the knowledge component, may help contribute to the definition and determination of competence in endoscopy.

A reliable data collection/control system

NASA Technical Reports Server (NTRS)

Maughan, Thom

1988-01-01

The Cal Poly Space Project requires a data collection/control system which must be able to reliably record temperature, pressure and vibration data. It must also schedule the 16 electroplating and 2 immiscible alloy experiments so as to optimize use of the batteries, maintain a safe package temperature profile, and run the experiment during conditions of microgravity (and minimum vibration). This system must operate unattended in the harsh environment of space and consume very little power due to limited battery supply. The design of a system which meets these requirements is addressed.

NASA Aerospace Flight Battery Systems Program Update

NASA Technical Reports Server (NTRS)

Manzo, Michelle; ODonnell, Patricia

1997-01-01

The objectives of NASA's Aerospace Flight Battery Systems Program is to: develop, maintain and provide tools for the validation and assessment of aerospace battery technologies; accelerate the readiness of technology advances and provide infusion paths for emerging technologies; provide NASA projects with the required database and validation guidelines for technology selection of hardware and processes relating to aerospace batteries; disseminate validation and assessment tools, quality assurance, reliability, and availability information to the NASA and aerospace battery communities; and ensure that safe, reliable batteries are available for NASA's future missions.

Proportional spike-timing precision and firing reliability underlie efficient temporal processing of periodicity and envelope shape cues

PubMed Central

Zheng, Y.

2013-01-01

Temporal sound cues are essential for sound recognition, pitch, rhythm, and timbre perception, yet how auditory neurons encode such cues is subject of ongoing debate. Rate coding theories propose that temporal sound features are represented by rate tuned modulation filters. However, overwhelming evidence also suggests that precise spike timing is an essential attribute of the neural code. Here we demonstrate that single neurons in the auditory midbrain employ a proportional code in which spike-timing precision and firing reliability covary with the sound envelope cues to provide an efficient representation of the stimulus. Spike-timing precision varied systematically with the timescale and shape of the sound envelope and yet was largely independent of the sound modulation frequency, a prominent cue for pitch. In contrast, spike-count reliability was strongly affected by the modulation frequency. Spike-timing precision extends from sub-millisecond for brief transient sounds up to tens of milliseconds for sounds with slow-varying envelope. Information theoretic analysis further confirms that spike-timing precision depends strongly on the sound envelope shape, while firing reliability was strongly affected by the sound modulation frequency. Both the information efficiency and total information were limited by the firing reliability and spike-timing precision in a manner that reflected the sound structure. This result supports a temporal coding strategy in the auditory midbrain where proportional changes in spike-timing precision and firing reliability can efficiently signal shape and periodicity temporal cues. PMID:23636724

Sandia National Laboratories: Fabrication, Testing and Validation

Science.gov Websites

; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas safe, secure, reliable, and can fully support the Nation's deterrence policy. Employing only the most support of this mission, Sandia National Laboratories has a significant role in advancing the "state

78 FR 30733 - Modernizing Federal Infrastructure Review and Permitting Regulations, Policies, and Procedures

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... Heads of Executive Departments and Agencies Reliable, safe, and resilient infrastructure is the backbone... and agencies (agencies) have achieved better outcomes for communities and the environment and realized... major infrastructure projects by half, while also improving outcomes for communities and the environment...

The Universal Anaesthesia Machine (UAM): assessment of a new anaesthesia workstation built with global health in mind.

PubMed

de Beer, D A H; Nesbitt, F D; Bell, G T; Rapuleng, A

2017-04-01

The Universal Anaesthesia Machine has been developed as a complete anaesthesia workstation for use in low- and middle-income countries, where the provision of safe general anaesthesia is often compromised by unreliable supply of electricity and anaesthetic gases. We performed a functional and clinical assessment of this anaesthetic machine, with particular reference to novel features and functioning in the intended environment. The Universal Anaesthesia Machine was found to be reliable, safe and consistent across a range of tests during targeted functional testing. © 2016 The Association of Anaesthetists of Great Britain and Ireland.

Safety considerations in the design and operation of large wind turbines

NASA Technical Reports Server (NTRS)

Reilly, D. H.

1979-01-01

The engineering and safety techniques used to assure the reliable and safe operation of large wind turbine generators utilizing the Mod 2 Wind Turbine System Program as an example is described. The techniques involve a careful definition of the wind turbine's natural and operating environments, use of proven structural design criteria and analysis techniques, an evaluation of potential failure modes and hazards, and use of a fail safe and redundant component engineering philosophy. The role of an effective quality assurance program, tailored to specific hardware criticality, and the checkout and validation program developed to assure system integrity are described.

Low cost high efficiency GaAs monolithic RF module for SARSAT distress beacons

NASA Technical Reports Server (NTRS)

Petersen, W. C.; Siu, D. P.; Cook, H. F.

1991-01-01

Low cost high performance (5 Watts output) 406 MHz beacons are urgently needed to realize the maximum utilization of the Search and Rescue Satellite-Aided Tracking (SARSAT) system spearheaded in the U.S. by NASA. Although current technology can produce beacons meeting the output power requirement, power consumption is high due to the low efficiency of available transmitters. Field performance is currently unsatisfactory due to the lack of safe and reliable high density batteries capable of operation at -40 C. Low cost production is also a crucial but elusive requirement for the ultimate wide scale utilization of this system. Microwave Monolithics Incorporated (MMInc.) has proposed to make both the technical and cost goals for the SARSAT beacon attainable by developing a monolithic GaAs chip set for the RF module. This chip set consists of a high efficiency power amplifier and a bi-phase modulator. In addition to implementing the RF module in Monolithic Microwave Integrated Circuit (MMIC) form to minimize ultimate production costs, the power amplifier has a power-added efficiency nearly twice that attained with current commercial technology. A distress beacon built using this RF module chip set will be significantly smaller in size and lighter in weight due to a smaller battery requirement, since the 406 MHz signal source and the digital controller have far lower power consumption compared to the 5 watt power amplifier. All the program tasks have been successfully completed. The GaAs MMIC RF module chip set has been designed to be compatible with the present 406 MHz signal source and digital controller. A complete high performance low cost SARSAT beacon can be realized with only additional minor iteration and systems integration.

A single-loop optimization method for reliability analysis with second order uncertainty

NASA Astrophysics Data System (ADS)

Xie, Shaojun; Pan, Baisong; Du, Xiaoping

2015-08-01

Reliability analysis may involve random variables and interval variables. In addition, some of the random variables may have interval distribution parameters owing to limited information. This kind of uncertainty is called second order uncertainty. This article develops an efficient reliability method for problems involving the three aforementioned types of uncertain input variables. The analysis produces the maximum and minimum reliability and is computationally demanding because two loops are needed: a reliability analysis loop with respect to random variables and an interval analysis loop for extreme responses with respect to interval variables. The first order reliability method and nonlinear optimization are used for the two loops, respectively. For computational efficiency, the two loops are combined into a single loop by treating the Karush-Kuhn-Tucker (KKT) optimal conditions of the interval analysis as constraints. Three examples are presented to demonstrate the proposed method.

Energy-Efficient Homes (Done Right)

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2017-07-31

Home energy upgrade measures allow individuals to enjoy a safe, comfortable, and energy-efficient home. But how do you know if the work is done right? Learn how the U.S Department of Energy and its National Renewable Energy Laboratory are working to ensure that energy efficient measures are being installed correctly across the United States.

Current challenges in European oncology pharmacy practice.

PubMed

Hoppe-Tichy, Torsten

2010-03-01

The demand for pharmacy cancer services is expected to at least double over the next 10 years, as the population ages and new treatments are introduced. Safe and efficient handling of cytotoxic products minimises risks to staff and reduces medication errors. To identify and describe strategies for coping safely and effectively with heavier workloads in the hospital oncology pharmacy, currently and in the future. The PubMed database was searched for literature on approaches to safe handling of antineoplastic agents and to decreasing medication errors in the hospital pharmacy. Articles that were judged to be of prime importance to the hospital oncologist were reviewed. These safety concepts are put into the context of contemporary hospital oncology pharmacy practice through discussion of key issues, including increased demand, the role of the pharmacist in determining the hospital formulary, and growth in patient preferences for oral chemotherapy. Recommendations on best practices are also provided, based on relevant literature and author experience. Efficient, safe hospital pharmacy operations can be aided by capacity planning, dose banding, and knowledge of novel products and procedures that can reduce risks to health while increasing the number of patients who are safely treated. Consideration may also be given to the economic role of oncology pharmacists in formulary development.

Acceptability and Use of Portable Drinking Water and Hand Washing Stations in Health Care Facilities and Their Impact on Patient Hygiene Practices, Western Kenya

PubMed Central

Otieno, Ronald; Odhiambo, Aloyce; Faith, Sitnah H.

2015-01-01

Many health care facilities (HCF) in developing countries lack access to reliable hand washing stations and safe drinking water. To address this problem, we installed portable, low-cost hand washing stations (HWS) and drinking water stations (DWS), and trained healthcare workers (HCW) on hand hygiene, safe drinking water, and patient education techniques at 200 rural HCFs lacking a reliable water supply in western Kenya. We performed a survey at baseline and a follow-up evaluation at 15 months to assess the impact of the intervention at a random sample of 40 HCFs and 391 households nearest to these HCFs. From baseline to follow-up, there was a statistically significant increase in the percentage of dispensaries with access to HWSs with soap (42% vs. 77%, p<0.01) and access to safe drinking water (6% vs. 55%, p<0.01). Female heads of household in the HCF catchment area exhibited statistically significant increases from baseline to follow-up in the ability to state target times for hand washing (10% vs. 35%, p<0.01), perform all four hand washing steps correctly (32% vs. 43%, p = 0.01), and report treatment of stored drinking water using any method (73% vs. 92%, p<0.01); the percentage of households with detectable free residual chlorine in stored drinking water did not change (6%, vs. 8%, p = 0.14). The installation of low-cost, low-maintenance, locally-available, portable hand washing and drinking water stations in rural HCFs without access to 24-hour piped water helped assure that health workers had a place to wash their hands and provide safe drinking water. This HCF intervention may have also contributed to the improvement of hand hygiene and reported safe drinking water behaviors among households nearest to HCFs. PMID:25961293

Acceptability and use of portable drinking water and hand washing stations in health care facilities and their impact on patient hygiene practices, Western kenya.

PubMed

Bennett, Sarah D; Otieno, Ronald; Ayers, Tracy L; Odhiambo, Aloyce; Faith, Sitnah H; Quick, Robert

2015-01-01

Many health care facilities (HCF) in developing countries lack access to reliable hand washing stations and safe drinking water. To address this problem, we installed portable, low-cost hand washing stations (HWS) and drinking water stations (DWS), and trained healthcare workers (HCW) on hand hygiene, safe drinking water, and patient education techniques at 200 rural HCFs lacking a reliable water supply in western Kenya. We performed a survey at baseline and a follow-up evaluation at 15 months to assess the impact of the intervention at a random sample of 40 HCFs and 391 households nearest to these HCFs. From baseline to follow-up, there was a statistically significant increase in the percentage of dispensaries with access to HWSs with soap (42% vs. 77%, p<0.01) and access to safe drinking water (6% vs. 55%, p<0.01). Female heads of household in the HCF catchment area exhibited statistically significant increases from baseline to follow-up in the ability to state target times for hand washing (10% vs. 35%, p<0.01), perform all four hand washing steps correctly (32% vs. 43%, p = 0.01), and report treatment of stored drinking water using any method (73% vs. 92%, p<0.01); the percentage of households with detectable free residual chlorine in stored drinking water did not change (6%, vs. 8%, p = 0.14). The installation of low-cost, low-maintenance, locally-available, portable hand washing and drinking water stations in rural HCFs without access to 24-hour piped water helped assure that health workers had a place to wash their hands and provide safe drinking water. This HCF intervention may have also contributed to the improvement of hand hygiene and reported safe drinking water behaviors among households nearest to HCFs.

48 CFR 23.000 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE..., and encouraging the safe operation of vehicles by— (a) Controlling pollution; (b) Managing energy and water use in Government facilities efficiently; (c) Using renewable energy and renewable energy...

Railway Transportation Engineering (CEE 408) Course updates and online conversion.

DOT National Transportation Integrated Search

2017-01-20

The new order of lectures provides students with a sound introduction to the main concepts behind efficiency and economic railway operations. This naturally follows into the design of railcars for safe, efficient and economical operations. With railc...

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 60%) of non-greenhouse-gas-emitting electric power generation in the United States. Domestic demand for electrical energy is expected to grow by about 24% from 2013 to 2040 . At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license, for a total of 60 years of operation (the oldest commercial plants in the Unitedmore » States reached their 40th anniversary in 2009). Figure E-1 shows projected nuclear energy contribution to the domestic generating capacity for 40- and 60-year license periods. If current operating nuclear power plants do not operate beyond 60 years (and new nuclear plants are not built quickly enough to replace them), the total fraction of generated electrical energy from nuclear power will rapidly decline. That decline will be accelerated if plants are shut down before 60 years of operation. Decisions on extended operation ultimately rely on economic factors; however, economics can often be improved through technical advancements. The U.S. Department of Energy Office of Nuclear Energy's 2010 Research and Development Roadmap (2010 Nuclear Energy Roadmap) organizes its activities around four objectives that ensure nuclear energy remains a compelling and viable energy option for the United States. The four objectives are as follows: 1. Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors; 2. Develop improvements in the affordability of new reactors to enable nuclear energy to help meet the Administration's energy security and climate change goals; 3. Develop sustainable nuclear fuel cycles; and 4. Understand and minimize the risks of nuclear proliferation and terrorism. The Light Water Reactor Sustainability (LWRS) Program is the primary programmatic activity that addresses Objective 1. This document summarizes the LWRS Program's plans. For the LWRS Program, sustainability is defined as the ability to maintain safe and economic operation of the existing fleet of nuclear power plants for a longer-than-initially-licensed lifetime. It has two facets with respect to long-term operations: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the industry to implement technology to exceed the performance of the current labor-intensive business model.« less

Interaction Entropy: A New Paradigm for Highly Efficient and Reliable Computation of Protein-Ligand Binding Free Energy.

PubMed

Duan, Lili; Liu, Xiao; Zhang, John Z H

2016-05-04

Efficient and reliable calculation of protein-ligand binding free energy is a grand challenge in computational biology and is of critical importance in drug design and many other molecular recognition problems. The main challenge lies in the calculation of entropic contribution to protein-ligand binding or interaction systems. In this report, we present a new interaction entropy method which is theoretically rigorous, computationally efficient, and numerically reliable for calculating entropic contribution to free energy in protein-ligand binding and other interaction processes. Drastically different from the widely employed but extremely expensive normal mode method for calculating entropy change in protein-ligand binding, the new method calculates the entropic component (interaction entropy or -TΔS) of the binding free energy directly from molecular dynamics simulation without any extra computational cost. Extensive study of over a dozen randomly selected protein-ligand binding systems demonstrated that this interaction entropy method is both computationally efficient and numerically reliable and is vastly superior to the standard normal mode approach. This interaction entropy paradigm introduces a novel and intuitive conceptual understanding of the entropic effect in protein-ligand binding and other general interaction systems as well as a practical method for highly efficient calculation of this effect.

VISIR: technological infrastructure of an operational service for safe and efficient navigation in the Mediterranean Sea

NASA Astrophysics Data System (ADS)

Mannarini, Gianandrea; Turrisi, Giuseppe; D'Anca, Alessandro; Scalas, Mario; Pinardi, Nadia; Coppini, Giovanni; Palermo, Francesco; Carluccio, Ivano; Scuro, Matteo; Cretì, Sergio; Lecci, Rita; Nassisi, Paola; Tedesco, Luca

2016-08-01

VISIR (discoVerIng Safe and effIcient Routes) is an operational decision support system (DSS) for optimal ship routing designed and implemented in the frame of the TESSA (TEchnology for Situational Sea Awareness) project. The system is aimed to increase safety and efficiency of navigation through the use of forecast environmental fields and route optimization. VISIR can be accessed through a web interface (www.visir-nav.com) and mobile applications for both iOS and Android devices. This paper focuses on the technological infrastructure developed for operating VISIR as a DSS. Its main components are described, the performance of the operational system is assessed through experimental measurements, and a few case studies are presented.

Nanoassemblies from homostructured polypeptides as efficient nanoplatforms for oral drug delivery.

PubMed

Jia, Yi; Tang, Yuan; He, Hongmei; Li, Shuhui; Che, Ling; Zhou, Xing; Dou, Yin; Zhang, Jianxiang; Li, Xiaohui

2013-04-01

The assembly of homostructured polypeptides bearing various side groups into well-defined nanostructures was presented, with their size and topology mainly dominated by the chemical structure and molecular weight of peptides. Pharmacokinetic and pharmacodynamic studies based on rat models suggested these newly constructed nanoassemblies with low cytotoxicity may function as novel nanoplatforms to efficiently and safely deliver therapeutics to achieve better efficacy but lower side effects. Other applications in biomedical fields, such as biotechnology, medical imaging, and tissue engineering, may also be expected. This research team investigated the assembly of homostructured polypeptides bearing various side groups into well-defined nanostructures, and demonstrated low cytotoxicity in rat disease models, suggesting that these novel nanoplatforms may safely and efficiently deliver therapeutics with low side effects. Copyright © 2013 Elsevier Inc. All rights reserved.

Efficient eye-safe neodymium doped composite yttrium gallium garnet crystal laser.

PubMed

Yu, Haohai; Wang, Shuxian; Han, Shuo; Wu, Kui; Su, Liangbi; Zhang, Huaijin; Wang, Zhengping; Xu, Jun; Wang, Jiyang

2014-03-15

We report a laser-diode pumped continuous-wave (cw) and passively Q-switched eye-safe laser at about 1.42 μm with the neodymium-doped yttrium gallium garnet (Nd:YGG) crystal for the first time to our knowledge. The composite Nd:YGG crystal was developed originally. A systematic comparison of laser performance between the homogeneously doped and composite Nd:YGG crystal was made, which showed that the composite Nd:YGG manifested less thermally induced effects. Cw output power of 2.06 W was obtained with the slope efficiency of 20.7%. With a V:YAG as a saturable absorber, the passive Q-switching at 1.42 μm was gotten with the pulse width, pulse energy, and peak power of 34 ns, 46.7 μJ, and 1.4 kW, respectively. The present work should provide a potential candidate for the generation of eye-safe lasers.

Study of the efficiency of some water treatment unit that present in houses in Erbil city-Iraq

NASA Astrophysics Data System (ADS)

Toma, Janan. Jabbar.; Hanna, Aveen. Matti.

2017-09-01

Many people in Erbil city started more than two decade to put special treatment units in their houses to purified water to become safer for drinking uses. The aim of this study was determine the efficiency of six kind water treatment units which include (two replicate of Crystal Water Purifier, So-Safe Water Filter, R O Water Purifier, Kontec Water Purified and Al-Kawther Purified Water). Water samples were collected in two sites one before and other after treatment unit. Each sample was collect with three replication during May to October-2016. Analyzed for Major cations concentration (calcium, magnesium, sodium and potassium), anions concentration (nitrate and chloride) and hydrogen ion concentration (pH), electrical conductivity (EC), total dissolved solids (TDS), alkalinity and total hardness by using standard methods. The water quality index values for all raw water sample befor and after treatment was good and excellent respectively for drinking purposes. Efficiency of So-Safe Water Filter was 66.32% it means was more efficiency than others special water treatment units while in RO Water Purifier was 27.14%, means less efficiency than other water purifier water under this study. Values for major cations, anions and others chemicals characteristics in the water samples after treatment became lower concentrations than befor treatment, likely an indication that these were removed by treatment. According to guideline of world health organization all of variables except total hardness befor treatment are safe and suitable for drinking purposes.

Toward Reliable and Energy Efficient Wireless Sensing for Space and Extreme Environments

NASA Technical Reports Server (NTRS)

Choi, Baek-Young; Boyd, Darren; Wilkerson, DeLisa

2017-01-01

Reliability is the critical challenge of wireless sensing in space systems operating in extreme environments. Energy efficiency is another concern for battery powered wireless sensors. Considering the physics of wireless communications, we propose an approach called Software-Defined Wireless Communications (SDC) that dynamically decide a reliable channel(s) avoiding unnecessary redundancy of channels, out of multiple distinct electromagnetic frequency bands such as radio and infrared frequencies.We validate the concept with Android and Raspberry Pi sensors and pseudo extreme experiments. SDC can be utilized in many areas beyond space applications.

Defense Experimentation and Stockpile Stewardship

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-10-28

A primary mission of the site is to help ensure that the nation's nuclear weapon stockpile remains safe, secure and reliable. The stockpile stewardship program, working with the national weapons laboratories conducts a wide range of experiments using advanced diagnostic technologies, many of which were developed right here at the NNSS.

40 CFR 180.5 - Zero tolerances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... tolerances. A zero tolerance means that no amount of the pesticide chemical may remain on the raw... raw agricultural commodity may be established because, among other reasons: (a) A safe level of the pesticide chemical in the diet of two different species of warm-blooded animals has not been reliably...

40 CFR 180.5 - Zero tolerances.

Code of Federal Regulations, 2010 CFR

2010-07-01

... tolerances. A zero tolerance means that no amount of the pesticide chemical may remain on the raw... raw agricultural commodity may be established because, among other reasons: (a) A safe level of the pesticide chemical in the diet of two different species of warm-blooded animals has not been reliably...

School Climate Measurement and Analysis

ERIC Educational Resources Information Center

Faster, Darlene; Lopez, Daisy

2013-01-01

Today, school climate assessment has become an increasingly important and valued aspect of district, state, and federal policy. Recognizing that effective school climate improvement efforts are grounded in valid and reliable data, the Federal Department of Education launched the Safe and Supportive Schools grant in 2010 to provide 11 states with…

Microwave and radiofrequency techniques for clinical hyperthermia.

PubMed Central

Cheung, A. Y.

1982-01-01

Biological and practical constraints on the use of clinical hyperthermia for the management of cancer are discussed. Commonly used electromagnetic techniques for producing clinical hyperthermia are reviewed and compared. Innovative engineering designs leading to the realization of an integrated, safe and reliable clinical hyperthermia system are also presented. PMID:6950753

Operations and Maintenance Introductory O&M Newsletter | Poster

Cancer.gov

The Operations and Maintenance (O&M) department has been serving and supporting the NCI scientific mission since 1972. Our dedicated staff works 24/7 behind the scenes to ensure that the NCI campus and laboratory environments are safe, functional, and reliable, as well as comfortable and aesthetically pleasing.

Defense Experimentation and Stockpile Stewardship

ScienceCinema

None

2018-01-16

A primary mission of the site is to help ensure that the nation's nuclear weapon stockpile remains safe, secure and reliable. The stockpile stewardship program, working with the national weapons laboratories conducts a wide range of experiments using advanced diagnostic technologies, many of which were developed right here at the NNSS.

Human Research Program Opportunities

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.

2014-01-01

The goal of HRP is to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Human Research Program was designed to meet the needs of human space exploration, and understand and reduce the risk to crew health and performance in exploration missions.

Teamwork and communication.

PubMed

Pfrimmer, Dale

2009-07-01

Effective teamwork and communication is critical to the delivery of safe and reliable patient care. Communication breakdowns account for the overwhelming majority of sentinel events. Effective teamwork and communication can help prevent mistakes and decrease patient risk. The implementation of simple tools and behaviors can greatly enhance patient safety and improve perceptions of teamwork.

Power Goals for the NASA Exploration Program

NASA Technical Reports Server (NTRS)

Jeevarajan, J.

2009-01-01

This slide presentation reviews the requirements for electrical power for future NASA exploration missions to the lunar surface. A review of the Constellation program is included as an introduction to the review of the batteries required for safe and reliable power for the ascent stage of the Altair Lunar Lander module.

Vesicoureteral reflux in children: a phantom study of microwave heating and radiometric thermometry of pediatric bladder.

PubMed

Birkelund, Yngve; Klemetsen, Øystein; Jacobsen, Svein K; Arunachalam, Kavitha; Maccarini, Paolo; Stauffer, Paul R

2011-11-01

We have investigated the use of microwave heating and radiometry to safely heat urine inside a pediatric bladder. The medical application for this research is to create a safe and reliable method to detect vesicoureteral reflux, a pediatric disorder, where urine flow is reversed and flows from the bladder back up into the kidney. Using fat and muscle tissue models, we have performed both experimental and numerical simulations of a pediatric bladder model using planar dual concentric conductor microstrip antennas at 915 MHz for microwave heating. A planar elliptical antenna connected to a 500 MHz bandwidth microwave radiometer centered at 3.5 GHz was used for noninvasive temperature measurement inside tissue. Temperatures were measured in the phantom models at points during the experiment with implanted fiberoptic sensors, and 2-D distributions in cut planes at depth in the phantom with an infrared camera at the end of the experiment. Cycling between 20 s with 20 Watts power for heating, and 10 s without power to allow for undisturbed microwave radiometry measurements, the experimental results show that the target tissue temperature inside the phantom increases fast and that the radiometer provides useful measurements of spatially averaged temperature of the illuminated volume. The presented numerical and experimental results show excellent concordance, which confirms that the proposed system for microwave heating and radiometry is applicable for safe and reliable heating of pediatric bladder.

Inherently Safe and Long-Life Fission Power System for Lunar Outposts

NASA Astrophysics Data System (ADS)

Schriener, T. M.; El-Genk, Mohamed S.

Power requirements for future lunar outposts, of 10's to 100's kWe, can be fulfilled using nuclear reactor power systems. In addition to the long life and operation reliability, safety is paramount in all phases, including fabrication and assembly, launch, emplacement below grade on the lunar surface, operation, post-operation decay heat removal and long-term storage and eventual retrieval. This paper introduces the Solid Core-Sectored Compact Reactor (SC-SCoRe) and power system with static components and no single point failures. They ensure reliable continuous operation for ~21 years and fulfill the safety requirements. The SC-SCoRe nominally generates 1.0 MWth at liquid NaK-56 coolant inlet and exit temperatures of 850 K and 900 K and the power system provides 38 kWe at high DC voltage using SiGe thermoelectric (TE) conversion assemblies. In case of a loss of coolant or cooling in a reactor core sector, the power system continues to operate; generating ~4 kWe to the outpost for emergency life support needs. The post-operation storage of the reactor below grade on the lunar surface is a safe and practical choice. The total radioactivity in the reactor drops from ~1 million Ci, immediately at shutdown, to below 164 Ci after 300 years of storage. At such time, the reactor is retrieved safely with no contamination or environmental concerns.

Systems Integration Fact Sheet

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2016-06-01

This fact sheet is an overview of the Systems Integration subprogram at the U.S. Department of Energy SunShot Initiative. The Systems Integration subprogram enables the widespread deployment of safe, reliable, and cost-effective solar energy technologies by addressing the associated technical and non-technical challenges. These include timely and cost-effective interconnection procedures, optimal system planning, accurate prediction of solar resources, monitoring and control of solar power, maintaining grid reliability and stability, and many more. To address the challenges associated with interconnecting and integrating hundreds of gigawatts of solar power onto the electricity grid, the Systems Integration program funds research, development, and demonstrationmore » projects in four broad, interrelated focus areas: grid performance and reliability, dispatchability, power electronics, and communications.« less

Reliability of drivers in urban intersections.

PubMed

Gstalter, Herbert; Fastenmeier, Wolfgang

2010-01-01

The concept of human reliability has been widely used in industrial settings by human factors experts to optimise the person-task fit. Reliability is estimated by the probability that a task will successfully be completed by personnel in a given stage of system operation. Human Reliability Analysis (HRA) is a technique used to calculate human error probabilities as the ratio of errors committed to the number of opportunities for that error. To transfer this notion to the measurement of car driver reliability the following components are necessary: a taxonomy of driving tasks, a definition of correct behaviour in each of these tasks, a list of errors as deviations from the correct actions and an adequate observation method to register errors and opportunities for these errors. Use of the SAFE-task analysis procedure recently made it possible to derive driver errors directly from the normative analysis of behavioural requirements. Driver reliability estimates could be used to compare groups of tasks (e.g. different types of intersections with their respective regulations) as well as groups of drivers' or individual drivers' aptitudes. This approach was tested in a field study with 62 drivers of different age groups. The subjects drove an instrumented car and had to complete an urban test route, the main features of which were 18 intersections representing six different driving tasks. The subjects were accompanied by two trained observers who recorded driver errors using standardized observation sheets. Results indicate that error indices often vary between both the age group of drivers and the type of driving task. The highest error indices occurred in the non-signalised intersection tasks and the roundabout, which exactly equals the corresponding ratings of task complexity from the SAFE analysis. A comparison of age groups clearly shows the disadvantage of older drivers, whose error indices in nearly all tasks are significantly higher than those of the other groups. The vast majority of these errors could be explained by high task load in the intersections, as they represent difficult tasks. The discussion shows how reliability estimates can be used in a constructive way to propose changes in car design, intersection layout and regulation as well as driver training.

Investigation of the impact of main control room digitalization on operators cognitive reliability in nuclear power plants.

PubMed

Zhou, Yong; Mu, Haiying; Jiang, Jianjun; Zhang, Li

2012-01-01

Currently, there is a trend in nuclear power plants (NPPs) toward introducing digital and computer technologies into main control rooms (MCRs). Safe generation of electric power in NPPs requires reliable performance of cognitive tasks such as fault detection, diagnosis, and response planning. The digitalization of MCRs has dramatically changed the whole operating environment, and the ways operators interact with the plant systems. If the design and implementation of the digital technology is incompatible with operators' cognitive characteristics, it may have negative effects on operators' cognitive reliability. Firstly, on the basis of three essential prerequisites for successful cognitive tasks, a causal model is constructed to reveal the typical human performance issues arising from digitalization. The cognitive mechanisms which they impact cognitive reliability are analyzed in detail. Then, Bayesian inference is used to quantify and prioritize the influences of these factors. It suggests that interface management and unbalanced workload distribution have more significant impacts on operators' cognitive reliability.

Semi-autonomous parking for enhanced safety and efficiency.

DOT National Transportation Integrated Search

2017-06-01

This project focuses on the use of tools from a combination of computer vision and localization based navigation schemes to aid the process of efficient and safe parking of vehicles in high density parking spaces. The principles of collision avoidanc...

Road weather forecast quality analysis

DOT National Transportation Integrated Search

2006-03-01

It is just as important to keep the highways functioning in a safe and efficient manner as it is to construct them in : the first place. Our economy is built around an efficient transportation system. Winter weather plays an important role : in highw...

Validity of instruments to assess students' travel and pedestrian safety

PubMed Central

2010-01-01

Background Safe Routes to School (SRTS) programs are designed to make walking and bicycling to school safe and accessible for children. Despite their growing popularity, few validated measures exist for assessing important outcomes such as type of student transport or pedestrian safety behaviors. This research validated the SRTS school travel survey and a pedestrian safety behavior checklist. Methods Fourth grade students completed a brief written survey on how they got to school that day with set responses. Test-retest reliability was obtained 3-4 hours apart. Convergent validity of the SRTS travel survey was assessed by comparison to parents' report. For the measure of pedestrian safety behavior, 10 research assistants observed 29 students at a school intersection for completion of 8 selected pedestrian safety behaviors. Reliability was determined in two ways: correlations between the research assistants' ratings to that of the Principal Investigator (PI) and intraclass correlations (ICC) across research assistant ratings. Results The SRTS travel survey had high test-retest reliability (κ = 0.97, n = 96, p < 0.001) and convergent validity (κ = 0.87, n = 81, p < 0.001). The pedestrian safety behavior checklist had moderate reliability across research assistants' ratings (ICC = 0.48) and moderate correlation with the PI (r = 0.55, p =< 0.01). When two raters simultaneously used the instrument, the ICC increased to 0.65. Overall percent agreement (91%), sensitivity (85%) and specificity (83%) were acceptable. Conclusions These validated instruments can be used to assess SRTS programs. The pedestrian safety behavior checklist may benefit from further formative work. PMID:20482778

Supplemental Driver Safety Program Development. Volume I--Development Research and Evaluation. Final Report.

ERIC Educational Resources Information Center

McPherson, Kenard; And Others

Instructional modules for driver education programs were prepared to improve safe driving knowledge, attitudes, and performances of 16- to 18-year-old drivers. These modules were designed to provide supplementary instruction in five content areas critical to the safe and efficient operation of motor vehicles by young drivers--speed management,…

78 FR 77608 - Requirements for Contacts with Federal Credit Unions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... an FCU official, NCUA has no way of ensuring the environment is safe for its employees or conducive to working efficiently and securely. NCUA staff who have conducted on-site contacts in homes have... other FCU contacts occur in a professional and safe setting. \\5\\ Id. 1766(j)(1). \\6\\ Id. 1789(a)(4). 3...

Evaluation of Safe Medication Administration through the Use of Simulation in an Academic Setting

ERIC Educational Resources Information Center

Dover, Cheryl D.

2013-01-01

Nursing educational programs are struggling with how to educate students to safely and efficiently administer medications. There is no doubt education programs need to find a way to assist students to acquire the skill of medication administration and to also transfer the skill into practice. Knowledge, skills, and abilities are requirements for…

Recent GE BWR fuel experience and design evolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wood, J.E.; Potts, G.A.; Proebstle, R.A.

1992-01-01

Reliable fuel operation is essential to the safe, reliable, and economic power production by today's commercial nuclear reactors. GE Nuclear Energy is committed to maximize fuel reliability through the progressive development of improved fuel design features and dedication to provide the maximum quality of the design features and dedication to provide the maximum quality of the design, fabrication, and operation of GE BWR fuel. Over the last 35 years, GE has designed, fabricated, and placed in operation over 82,000 BWR fuel bundles containing over 5 million fuel rods. This experience includes successful commercial reactor operation of fuel assemblies to greatermore » than 45000 MWd/MTU bundle average exposure. This paper reports that this extensive experience base has enabled clear identification and characterization of the active failure mechanisms. With this failure mechanism characterization, mitigating actions have been developed and implemented by GE to provide the highest reliability BWR fuel bundles possible.« less

Reliably detectable flaw size for NDE methods that use calibration

NASA Astrophysics Data System (ADS)

Koshti, Ajay M.

2017-04-01

Probability of detection (POD) analysis is used in assessing reliably detectable flaw size in nondestructive evaluation (NDE). MIL-HDBK-1823 and associated mh18232 POD software gives most common methods of POD analysis. In this paper, POD analysis is applied to an NDE method, such as eddy current testing, where calibration is used. NDE calibration standards have known size artificial flaws such as electro-discharge machined (EDM) notches and flat bottom hole (FBH) reflectors which are used to set instrument sensitivity for detection of real flaws. Real flaws such as cracks and crack-like flaws are desired to be detected using these NDE methods. A reliably detectable crack size is required for safe life analysis of fracture critical parts. Therefore, it is important to correlate signal responses from real flaws with signal responses form artificial flaws used in calibration process to determine reliably detectable flaw size.

Reliably Detectable Flaw Size for NDE Methods that Use Calibration

NASA Technical Reports Server (NTRS)

Koshti, Ajay M.

2017-01-01

Probability of detection (POD) analysis is used in assessing reliably detectable flaw size in nondestructive evaluation (NDE). MIL-HDBK-1823 and associated mh1823 POD software gives most common methods of POD analysis. In this paper, POD analysis is applied to an NDE method, such as eddy current testing, where calibration is used. NDE calibration standards have known size artificial flaws such as electro-discharge machined (EDM) notches and flat bottom hole (FBH) reflectors which are used to set instrument sensitivity for detection of real flaws. Real flaws such as cracks and crack-like flaws are desired to be detected using these NDE methods. A reliably detectable crack size is required for safe life analysis of fracture critical parts. Therefore, it is important to correlate signal responses from real flaws with signal responses form artificial flaws used in calibration process to determine reliably detectable flaw size.

Failure analysis of solid rocket apogee motors

NASA Technical Reports Server (NTRS)

Martin, P. J.

1972-01-01

The analysis followed five selected motors through initial design, development, test, qualification, manufacture, and final flight reports. An audit was conducted at the manufacturing plants to complement the literature search with firsthand observations of the current philosophies and practices that affect reliability of the motors. A second literature search emphasized acquisition of spacecraft and satellite data bearing on solid motor reliability. It was concluded that present practices at the plants yield highly reliable flight hardware. Reliability can be further improved by new developments of aft-end bonding and initiator/igniter nondestructive test methods, a safe/arm device, and an insulation formulation. Minimum diagnostic instrumentation is recommended for all motor flights. Surplus motors should be used in margin testing. Criteria should be established for pressure and zone curing. The motor contractor should be represented at launch. New design analyses should be made of stretched motors and spacecraft/motor pairs.

Eye Safe, Visible Wavelength Lidar Systems: Design and Operational Advances, Results and Potential

NASA Technical Reports Server (NTRS)

Spinhirne, James; Welton, Ellsworth J.; Berkoff, Timothy; Campbell, James

2007-01-01

In the early nineties the first of the eye safe visible wavelength lidar systems known now as Micro Pulse Lidar (MPL) became operational. The important advance of the design was a system that, unlike most existing lidar, operated at eye safe energy densities and could thus operate unattended for full time monitoring. Since that time there have been many dozens of these systems produced and applied for full time profiling of atmospheric cloud and aerosol structure. There is currently an observational network of MPL sites to support global climate research. In thc course of application of these instruments there have been significant improvements in the, design and performance of the systems. In the last half decade particularly there has been significant application and technical development of MPL systems. In this paper we review progress. The current MPL systems in use are all single wavelength systems designed for cloud and aerosol applications. For the cloud and aerosol applications, both lidar depolarization and multi wavelength measurements have significant applications. These can be accomplished with the MPL, approach. The main current challenge for the lidar network activity are in the area of the reliability, repeatability and efficiency of data processing. The network makes use of internet data downloads and automated processing. The heights of all cloud and aerosol layers are needed. The recent emphasis has been in operationally deriving aerosol extinction cross section. Future emphasis will include adding cirrus optical parameters. For operational effectiveness, improvements to simplify routine data signal calibration are being researched. Overall the MPL systems have proven very effective. A large data base of results from globally distributed sites can be easily accessed through the internet. Applications have included atmospheric model development. Validation of current global satellite observations of aerosol and clouds, including now orbital lidar observations, was a primary goal for NASA. Although sampling issues require careful consideration, results have proven useful.

Bandwidth efficient coding for satellite communications

NASA Technical Reports Server (NTRS)

Lin, Shu; Costello, Daniel J., Jr.; Miller, Warner H.; Morakis, James C.; Poland, William B., Jr.

1992-01-01

An error control coding scheme was devised to achieve large coding gain and high reliability by using coded modulation with reduced decoding complexity. To achieve a 3 to 5 dB coding gain and moderate reliability, the decoding complexity is quite modest. In fact, to achieve a 3 dB coding gain, the decoding complexity is quite simple, no matter whether trellis coded modulation or block coded modulation is used. However, to achieve coding gains exceeding 5 dB, the decoding complexity increases drastically, and the implementation of the decoder becomes very expensive and unpractical. The use is proposed of coded modulation in conjunction with concatenated (or cascaded) coding. A good short bandwidth efficient modulation code is used as the inner code and relatively powerful Reed-Solomon code is used as the outer code. With properly chosen inner and outer codes, a concatenated coded modulation scheme not only can achieve large coding gains and high reliability with good bandwidth efficiency but also can be practically implemented. This combination of coded modulation and concatenated coding really offers a way of achieving the best of three worlds, reliability and coding gain, bandwidth efficiency, and decoding complexity.

Optimal robust control strategy of a solid oxide fuel cell system

NASA Astrophysics Data System (ADS)

Wu, Xiaojuan; Gao, Danhui

2018-01-01

Optimal control can ensure system safe operation with a high efficiency. However, only a few papers discuss optimal control strategies for solid oxide fuel cell (SOFC) systems. Moreover, the existed methods ignore the impact of parameter uncertainty on system instantaneous performance. In real SOFC systems, several parameters may vary with the variation of operation conditions and can not be identified exactly, such as load current. Therefore, a robust optimal control strategy is proposed, which involves three parts: a SOFC model with parameter uncertainty, a robust optimizer and robust controllers. During the model building process, boundaries of the uncertain parameter are extracted based on Monte Carlo algorithm. To achieve the maximum efficiency, a two-space particle swarm optimization approach is employed to obtain optimal operating points, which are used as the set points of the controllers. To ensure the SOFC safe operation, two feed-forward controllers and a higher-order robust sliding mode controller are presented to control fuel utilization ratio, air excess ratio and stack temperature afterwards. The results show the proposed optimal robust control method can maintain the SOFC system safe operation with a maximum efficiency under load and uncertainty variations.

Effective and economical cleaning of pipes and underdrains : phase 1.

DOT National Transportation Integrated Search

2017-03-01

The Ohio Department of Transportation (ODOT) maintains 43,000 lane miles of roadway in order to allow the public to : safely and efficiently travel throughout Ohio. Pavement conditions play a major role in the efficiency and safety of the : traveling...

Extraction kinetics and properties of proanthocyanidins from pomegranate peel

USDA-ARS?s Scientific Manuscript database

With an objective of developing a safe and efficient method to extract proanthocyanidins products from pomegranate peel for use in nutraceuticals or as food additives, the effects of extraction parameters on the production efficiency, product properties, and extraction kinetics were systematically s...

New Generation Lidar Technology and Applications

NASA Technical Reports Server (NTRS)

Spinhirne, James D.

1999-01-01

Lidar has been a tool for atmospheric research for several decades. Until recently routine operational use of lidar was not known. Problems have involved a lack of appropriate technology rather than a lack of applications. Within the last few years, lidar based on a new generation of solid state lasers and detectors have changed the situation. Operational applications for cloud and aerosol research applications are now well established. In these research applications, the direct height profiling capability of lidar is typically an adjunct to other types of sensing, both passive and active. Compact eye safe lidar with the sensitivity for ground based monitoring of all significant cloud and aerosol structure and the reliability to operate full time for several years is now in routine use. The approach is known as micro pulse lidar (MPL). For MPL the laser pulse repetition rate is in the kilohertz range and the pulse energies are in the micro-Joule range. The low pulse energy permits the systems to be eye safe and reliable with solid state lasers. A number of MPL systems have been deployed since 1992 at atmospheric research sites at a variety of global locations. Accurate monitoring of cloud and aerosol vertical distribution is a critical measurement for atmospheric radiation. An airborne application of lidar cloud and aerosol profiling is retrievals of parameters from combined lidar and passive sensing involving visible, infrared and microwave frequencies. A lidar based on a large pulse, solid state diode pumped ND:YAG laser has been deployed on the NASA ER-2 high altitude research aircraft along with multi-spectral visible/IR and microwave imaging radiometers since 1993. The system has shown high reliability in an extensive series of experimental projects for cloud remote sensing. The retrieval of cirrus radiation parameters is an effective application for combined lidar and passive sensing. An approved NASA mission will soon begin long term lidar observation of atmospheric structure from space. The Geoscience Laser Altimeter System (GLAS) of the Earth Observing System is scheduled for deployment in the 2001 time frame. GLAS is both a cloud and aerosol lidar and a surface altimeter, principally for monitoring of polar ice sheets. The GLAS instrument is based on all solid state lasers operating at 40 Hz and high efficiency, solid state detectors. The design lifetime is three to five years. Data from the GLAS mission is expected to revolutionize some aspects of our understanding of the global distribution of cloud and aerosols for global climate prediction.

Barium Nitrate Raman Laser Development for Remote Sensing of Ozone

NASA Technical Reports Server (NTRS)

McCray, Christopher L.; Chyba, Thomas H.

1997-01-01

In order to understand the impact of anthropogenic emissions upon the earth's environment, scientists require remote sensing techniques which are capable of providing range-resolved measurements of clouds, aerosols, and the concentrations of several chemical constituents of the atmosphere. The differential absorption lidar (DIAL) technique is a very promising method to measure concentration profiles of chemical species such as ozone and water vapor as well as detect the presence of aerosols and clouds. If a suitable DIAL system could be deployed in space, it would provide a global data set of tremendous value. Such systems, however, need to be compact, reliable, and very efficient. In order to measure atmospheric gases with the DIAL technique, the laser transmitter must generate suitable on-line and off-line wavelength pulse pairs. The on-line pulse is resonant with an absorption feature of the species of interest. The off-line pulse is tuned so that it encounters significantly less absorption. The relative backscattered power for the two pulses enables the range-resolved concentration to be computed. Preliminary experiments at NASA LaRC suggested that the solid state Raman shifting material, Ba(NO3)2, could be utilized to produce these pulse pairs. A Raman oscillator pumped at 532 nm by a frequency-doubled Nd:YAG laser can create first Stokes laser output at 563 nm and second Stokes output at 599 nm. With frequency doublers, UV output at 281 nm and 299 nm can be subsequently obtained. This all-solid state system has the potential to be very efficient, compact, and reliable. Raman shifting in Ba(NO3)2, has previously been performed in both the visible and the infrared. The first Raman oscillator in the visible region was investigated in 1986 with the configurations of plane-plane and unstable telescopic resonators. However, most of the recent research has focused on the development of infrared sources for eye-safe lidar applications.

Composite Stress Rupture: A New Reliability Model Based on Strength Decay

NASA Technical Reports Server (NTRS)

Reeder, James R.

2012-01-01

A model is proposed to estimate reliability for stress rupture of composite overwrap pressure vessels (COPVs) and similar composite structures. This new reliability model is generated by assuming a strength degradation (or decay) over time. The model suggests that most of the strength decay occurs late in life. The strength decay model will be shown to predict a response similar to that predicted by a traditional reliability model for stress rupture based on tests at a single stress level. In addition, the model predicts that even though there is strength decay due to proof loading, a significant overall increase in reliability is gained by eliminating any weak vessels, which would fail early. The model predicts that there should be significant periods of safe life following proof loading, because time is required for the strength to decay from the proof stress level to the subsequent loading level. Suggestions for testing the strength decay reliability model have been made. If the strength decay reliability model predictions are shown through testing to be accurate, COPVs may be designed to carry a higher level of stress than is currently allowed, which will enable the production of lighter structures

Autonomous Assembly of Modular Structures in Space and on Extraterrestrial Locations

NASA Astrophysics Data System (ADS)

Alhorn, Dean C.

2005-02-01

The new U.S. National Vision for Space Exploration requires many new enabling technologies to accomplish the goals of space commercialization and returning humans to the moon and extraterrestrial environments. Traditionally, flight elements are complete sub-systems requiring humans to complete the integration and assembly. These bulky structures also require the use of heavy launch vehicles to send the units to a desired location. This philosophy necessitates a high degree of safety, numerous space walks at a significant cost. Future space mission costs must be reduced and safety increased to reasonably achieve exploration goals. One proposed concept is the autonomous assembly of space structures. This concept is an affordable, reliable solution to in-space and extraterrestrial assembly. Assembly is autonomously performed when two components join after determining that specifications are correct. Local sensors continue monitor joint integrity post assembly, which is critical for safety and structural reliability. Achieving this concept requires a change in space structure design philosophy and the development of innovative technologies to perform autonomous assembly. Assembly of large space structures will require significant numbers of integrity sensors. Thus simple, low-cost sensors are integral to the success of this concept. This paper addresses these issues and proposes a novel concept for assembling space structures autonomously. Core technologies required to achieve in space assembly are presented. These core technologies are critical to the goal of utilizing space in a cost efficient and safe manner. Additionally, these novel technologies can be applied to other systems both on earth and extraterrestrial environments.

Care provider allocation on admissions to acute mental health wards: The development and validation of the Admission Team Score List.

PubMed

van den Berg, Sjobha R N; Stringer, Barbara; van de Sande, Roland; Draisma, Stasja

2018-05-18

Currently, support tools are lacking to prioritize steps in the care coordination process to enable safe practice and effective clinical pathways in the first phase of acute psychiatric admissions. This study describes the development, validity, and reliability of an acute care coordination support tool, the Admission Team Score List (ATSL). The ATSL assists in care provider allocation during admissions. Face validity and feasibility of the ATSL were tested in 77 acute admissions. Endscores of filled out ATSL's were translated to recommended team compositions. These ATSL team (ATSL-T) compositions were compared to the actually present team (AP-T) and the most preferred team (MP-T) composition in hindsight. Consistency between the ATSL-T and the MP-T was substantial; K w  = 0.70, P < 0.001, 95% CI [0.55-0.84]. The consistency between the ATSL-T and AP-T was moderate; K w  = 0.43, P < 0.001, 95% CI [0.23-0.62]. The ATSL has an adequate (inter-rater) reliability; ICC = 0.90, P < 0.001, 95% CI [0.65-0.91]. The ATSL study is an important step to promote safety and efficient care based on care provider allocation, for service users experiencing an acute admission. The ATSL may stimulate structured clinical decision-making during the hectic process around acute psychiatric admissions. © 2018 Australian College of Mental Health Nurses Inc.

The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential.

PubMed

Janero, David R

2014-08-01

Technology often serves as a handmaiden and catalyst of invention. The discovery of safe, effective medications depends critically upon experimental approaches capable of providing high-impact information on the biological effects of drug candidates early in the discovery pipeline. This information can enable reliable lead identification, pharmacological compound differentiation and successful translation of research output into clinically useful therapeutics. The shallow preclinical profiling of candidate compounds promulgates a minimalistic understanding of their biological effects and undermines the level of value creation necessary for finding quality leads worth moving forward within the development pipeline with efficiency and prognostic reliability sufficient to help remediate the current pharma-industry productivity drought. Three specific technologies discussed herein, in addition to experimental areas intimately associated with contemporary drug discovery, appear to hold particular promise for strengthening the preclinical valuation of drug candidates by deepening lead characterization. These are: i) hydrogen-deuterium exchange mass spectrometry for characterizing structural and ligand-interaction dynamics of disease-relevant proteins; ii) activity-based chemoproteomics for profiling the functional diversity of mammalian proteomes; and iii) nuclease-mediated precision gene editing for developing more translatable cellular and in vivo models of human diseases. When applied in an informed manner congruent with the clinical understanding of disease processes, technologies such as these that span levels of biological organization can serve as valuable enablers of drug discovery and potentially contribute to reducing the current, unacceptably high rates of compound clinical failure.

Autonomous Assembly of Modular Structures in Space and on Extraterrestrial Locations

NASA Technical Reports Server (NTRS)

Alhorn, Dean C.

2005-01-01

The new U.S. National Vision for Space Exploration requires many new enabling technologies to accomplish the goals of space commercialization and returning humans to the moon and extraterrestrial environments. Traditionally, flight elements are complete subsystems requiring humans to complete the integration and assembly. These bulky structures also require the use of heavy launch vehicles to send the units to a desired location. This philosophy necessitates a high degree of safety, numerous space walks at a significant cost. Future space mission costs must be reduced and safety increased to reasonably achieve exploration goals. One proposed concept is the autonomous assembly of space structures. This concept is an affordable, reliable solution to in-space and extraterrestrial assembly. Assembly is autonomously performed when two components join after determining that specifications are correct. Local sensors continue monitor joint integrity post assembly, which is critical for safety and structural reliability. Achieving this concept requires a change in space structure design philosophy and the development of innovative technologies to perform autonomous assembly. Assembly of large space structures will require significant numbers of integrity sensors. Thus simple, low-cost sensors are integral to the success of this concept. This paper addresses these issues and proposes a novel concept for assembling space structures autonomously. Core technologies required to achieve in space assembly are presented. These core technologies are critical to the goal of utilizing space in a cost efficient and safe manner. Additionally, these novel technologies can be applied to other systems both on earth and extraterrestrial environments.

[Progress in transgenic fish techniques and application].

PubMed

Ye, Xing; Tian, Yuan-Yuan; Gao, Feng-Ying

2011-05-01

Transgenic technique provides a new way for fish breeding. Stable lines of growth hormone gene transfer carps, salmon and tilapia, as well as fluorescence protein gene transfer zebra fish and white cloud mountain minnow have been produced. The fast growth characteristic of GH gene transgenic fish will be of great importance to promote aquaculture production and economic efficiency. This paper summarized the progress in transgenic fish research and ecological assessments. Microinjection is still the most common used method, but often resulted in multi-site and multi-copies integration. Co-injection of transposon or meganuclease will greatly improve the efficiency of gene transfer and integration. "All fish" gene or "auto gene" should be considered to produce transgenic fish in order to eliminate misgiving on food safety and to benefit expression of the transferred gene. Environmental risk is the biggest obstacle for transgenic fish to be commercially applied. Data indicates that transgenic fish have inferior fitness compared with the traditional domestic fish. However, be-cause of the genotype-by-environment effects, it is difficult to extrapolate simple phenotypes to the complex ecological interactions that occur in nature based on the ecological consequences of the transgenic fish determined in the laboratory. It is critical to establish highly naturalized environments for acquiring reliable data that can be used to evaluate the environ-mental risk. Efficacious physical and biological containment strategies remain to be crucial approaches to ensure the safe application of transgenic fish technology.

New insights on poly(vinyl acetate)-based coated floating tablets: characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength.

PubMed

Strübing, Sandra; Abboud, Tâmara; Contri, Renata Vidor; Metz, Hendrik; Mäder, Karsten

2008-06-01

The purpose of this study was to investigate the mechanism of floating and drug release behaviour of poly(vinyl acetate)-based floating tablets with membrane controlled drug delivery. Propranolol HCl containing tablets with Kollidon SR as an excipient for direct compression and different Kollicoat SR 30 D/Kollicoat IR coats varying from 10 to 20mg polymer/cm2 were investigated regarding drug release in 0.1N HCl. Furthermore, the onset of floating, the floating duration and the floating strength of the device were determined. In addition, benchtop MRI studies of selected samples were performed. Coated tablets with 10mg polymer/cm2 SR/IR, 8.5:1.5 coat exhibited the shortest lag times prior to drug release and floating onset, the fastest increase in and highest maximum values of floating strength. The drug release was delayed efficiently within a time interval of 24 h by showing linear drug release characteristics. Poly(vinyl acetate) proved to be an appropriate excipient to ensure safe and reliable drug release. Floating strength measurements offered the possibility to quantify the floating ability of the developed systems and thus to compare different formulations more efficiently. Benchtop MRI studies allowed a deeper insight into drug release and floating mechanisms noninvasively and continuously.

A Survey of Intelligent Control and Health Management Technologies for Aircraft Propulsion Systems

NASA Technical Reports Server (NTRS)

Litt, Jonathan S.; Simon, Donald L.; Garg, Sanjay; Guo, Ten-Heui; Mercer, Carolyn; Behbahani, Alireza; Bajwa, Anupa; Jensen, Daniel T.

2005-01-01

Intelligent Control and Health Management technology for aircraft propulsion systems is much more developed in the laboratory than in practice. With a renewed emphasis on reducing engine life cycle costs, improving fuel efficiency, increasing durability and life, etc., driven by various government programs, there is a strong push to move these technologies out of the laboratory and onto the engine. This paper describes the existing state of engine control and on-board health management, and surveys some specific technologies under development that will enable an aircraft propulsion system to operate in an intelligent way--defined as self-diagnostic, self-prognostic, self-optimizing, and mission adaptable. These technologies offer the potential for creating extremely safe, highly reliable systems. The technologies will help to enable a level of performance that far exceeds that of today s propulsion systems in terms of reduction of harmful emissions, maximization of fuel efficiency, and minimization of noise, while improving system affordability and safety. Technologies that are discussed include various aspects of propulsion control, diagnostics, prognostics, and their integration. The paper focuses on the improvements that can be achieved through innovative software and algorithms. It concentrates on those areas that do not require significant advances in sensors and actuators to make them achievable, while acknowledging the additional benefit that can be realized when those technologies become available. The paper also discusses issues associated with the introduction of some of the technologies.

The Spin Move: A Reliable and Cost-Effective Gowning Technique for the 21st Century.

PubMed

Ochiai, Derek H; Adib, Farshad

2015-04-01

Operating room efficiency (ORE) and utilization are considered one of the most crucial components of quality improvement in every hospital. We introduced a new gowning technique that could optimize ORE. The Spin Move quickly and efficiently wraps a surgical gown around the surgeon's body. This saves the operative time expended through the traditional gowning techniques. In the Spin Move, while the surgeon is approaching the scrub nurse, he or she uses the left heel as the fulcrum. The torque, which is generated by twisting the right leg around the left leg, helps the surgeon to close the gown as quickly and safely as possible. From 2003 to 2012, the Spin Move was performed in 1,725 consecutive procedures with no complication. The estimated average time was 5.3 and 7.8 seconds for the Spin Move and traditional gowning, respectively. The estimated time saving for the senior author during this period was 71.875 minutes. Approximately 20,000 orthopaedic surgeons practice in the United States. If this technique had been used, 23,958 hours could have been saved. The money saving could have been $14,374,800.00 (23,958 hours × $600/operating room hour) during the past 10 years. The Spin Move is easy to perform and reproducible. It saves operating room time and increases ORE.

The Spin Move: A Reliable and Cost-Effective Gowning Technique for the 21st Century

PubMed Central

Ochiai, Derek H.; Adib, Farshad

2015-01-01

Operating room efficiency (ORE) and utilization are considered one of the most crucial components of quality improvement in every hospital. We introduced a new gowning technique that could optimize ORE. The Spin Move quickly and efficiently wraps a surgical gown around the surgeon's body. This saves the operative time expended through the traditional gowning techniques. In the Spin Move, while the surgeon is approaching the scrub nurse, he or she uses the left heel as the fulcrum. The torque, which is generated by twisting the right leg around the left leg, helps the surgeon to close the gown as quickly and safely as possible. From 2003 to 2012, the Spin Move was performed in 1,725 consecutive procedures with no complication. The estimated average time was 5.3 and 7.8 seconds for the Spin Move and traditional gowning, respectively. The estimated time saving for the senior author during this period was 71.875 minutes. Approximately 20,000 orthopaedic surgeons practice in the United States. If this technique had been used, 23,958 hours could have been saved. The money saving could have been $14,374,800.00 (23,958 hours × $600/operating room hour) during the past 10 years. The Spin Move is easy to perform and reproducible. It saves operating room time and increases ORE. PMID:26052490

Design Optimization Method for Composite Components Based on Moment Reliability-Sensitivity Criteria

NASA Astrophysics Data System (ADS)

Sun, Zhigang; Wang, Changxi; Niu, Xuming; Song, Yingdong

2017-08-01

In this paper, a Reliability-Sensitivity Based Design Optimization (RSBDO) methodology for the design of the ceramic matrix composites (CMCs) components has been proposed. A practical and efficient method for reliability analysis and sensitivity analysis of complex components with arbitrary distribution parameters are investigated by using the perturbation method, the respond surface method, the Edgeworth series and the sensitivity analysis approach. The RSBDO methodology is then established by incorporating sensitivity calculation model into RBDO methodology. Finally, the proposed RSBDO methodology is applied to the design of the CMCs components. By comparing with Monte Carlo simulation, the numerical results demonstrate that the proposed methodology provides an accurate, convergent and computationally efficient method for reliability-analysis based finite element modeling engineering practice.

Feasibility and fidelity of practising surgical fixation on a virtual ulna bone

PubMed Central

LeBlanc, Justin; Hutchison, Carol; Hu, Yaoping; Donnon, Tyrone

2013-01-01

Background Surgical simulators provide a safe environment to learn and practise psychomotor skills. A goal for these simulators is to achieve high levels of fidelity. The purpose of this study was to develop a reliable surgical simulator fidelity questionnaire and to assess whether a newly developed virtual haptic simulator for fixation of an ulna has comparable levels of fidelity as Sawbones. Methods Simulator fidelity questionnaires were developed. We performed a stratified randomized study with surgical trainees. They performed fixation of the ulna using a virtual simulator and Sawbones. They completed the fidelity questionnaires after each procedure. Results Twenty-two trainees participated in the study. The reliability of the fidelity questionnaire for each separate domain (environment, equipment, psychological) was Cronbach α greater than 0.70, except for virtual environment. The Sawbones had significantly higher levels of fidelity than the virtual simulator (p < 0.001) with a large effect size difference (Cohen d < 1.3). Conclusion The newly developed fidelity questionnaire is a reliable tool that can potentially be used to determine the fidelity of other surgical simulators. Increasing the fidelity of this virtual simulator is required before its use as a training tool for surgical fixation. The virtual simulator brings with it the added benefits of repeated, independent safe use with immediate, objective feedback and the potential to alter the complexity of the skill. PMID:23883510

Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles.

PubMed

Czugala, Marta; Mykhaylyk, Olga; Böhler, Philip; Onderka, Jasmine; Stork, Björn; Wesselborg, Sebastian; Kruse, Friedrich E; Plank, Christian; Singer, Bernhard B; Fuchsluger, Thomas A

2016-07-01

To develop a safe and efficient method for targeted, anti-apoptotic gene therapy of corneal endothelial cells (CECs). Magnetofection (MF), a combination of lipofection with magnetic nanoparticles (MNPs; PEI-Mag2, SO-Mag5, PalD1-Mag1), was tested in human CECs and in explanted human corneas. Effects on cell viability and function were investigated. Immunocompatibility was assessed in human peripheral blood mononuclear cells. Silica iron-oxide MNPs (SO-Mag5) combined with X-tremeGENE-HP achieved high transfection efficiency in human CECs and explanted human corneas, without altering cell viability or function. Magnetofection caused no immunomodulatory effects in human peripheral blood mononuclear cells. Magnetofection with anti-apoptotic P35 gene effectively blocked apoptosis in CECs. Magnetofection is a promising tool for gene therapy of corneal endothelial cells with potential for targeted on-site delivery.

Voltage Sag due to Pollution Induced Flashover Across Ceramic Insulator Strings

NASA Astrophysics Data System (ADS)

Reddy B, Subba; Goswami, Arup Kumar

2017-11-01

Voltage sag or voltage dips are significant to industrial reliability. There is a necessity to characterize the feeder level power quality (PQ) and the PQ performance among various utility companies. Contamination/pollution induced flashover is the ultimate consequence of the creeping discharges across the insulator strings which induce voltage sag. These have a severe threat on the safe and reliable operation of power systems. In the present work an attempt has been made to experimentally investigate the occurrence of voltage sag/dips during pollution induced flashovers. Results show significant dip/sag in the voltage magnitude during the flashover process.

Automatic Bone Drilling - More Precise, Reliable and Safe Manipulation in the Orthopaedic Surgery

NASA Astrophysics Data System (ADS)

Boiadjiev, George; Kastelov, Rumen; Boiadjiev, Tony; Delchev, Kamen; Zagurski, Kazimir

2016-06-01

Bone drilling manipulation often occurs in the orthopaedic surgery. By statistics, nowadays, about one million people only in Europe need such an operation every year, where bone implants are inserted. Almost always, the drilling is performed handily, which cannot avoid the subjective factor influence. The question of subjective factor reduction has its answer - automatic bone drilling. The specific features and problems of orthopaedic drilling manipulation are considered in this work. The automatic drilling is presented according the possibilities of robotized system Orthopaedic Drilling Robot (ODRO) for assuring the manipulation accuracy, precision, reliability and safety.

Main propulsion system design recommendations for an advanced Orbit Transfer Vehicle

NASA Technical Reports Server (NTRS)

Redd, L.

1985-01-01

Various main propulsion system configurations of an advanced OTV are evaluated with respect to the probability of nonindependent failures, i.e., engine failures that disable the entire main propulsion system. Analysis of the life-cycle cost (LCC) indicates that LCC is sensitive to the main propulsion system reliability, vehicle dry weight, and propellant cost; it is relatively insensitive to the number of missions/overhaul, failures per mission, and EVA and IVA cost. In conclusion, two or three engines are recommended in view of their highest reliability, minimum life-cycle cost, and fail operational/fail safe capability.

GN&C Engineering Best Practices for Human-Rated Spacecraft Systems

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.; Lebsock, Kenneth; West, John

2007-01-01

The NASA Engineering and Safety Center (NESC) recently completed an in-depth assessment to identify a comprehensive set of engineering considerations for the Design, Development, Test and Evaluation (DDT&E) of safe and reliable human-rated spacecraft systems. Reliability subject matter experts, discipline experts, and systems engineering experts were brought together to synthesize the current "best practices" both at the spacecraft system and subsystems levels. The objective of this paper is to summarize, for the larger Community of Practice, the initial set of Guidance, Navigation and Control (GN&C) engineering Best Practices as identified by this NESC assessment process.

GN&C Engineering Best Practices for Human-Rated Spacecraft System

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.; Lebsock, Kenneth; West, John

2008-01-01

The NASA Engineering and Safety Center (NESC) recently completed an in-depth assessment to identify a comprehensive set of engineering considerations for the Design, Development, Test and Evaluation (DDT&E) of safe and reliable human-rated spacecraft systems. Reliability subject matter experts, discipline experts, and systems engineering experts were brought together to synthesize the current "best practices" both at the spacecraft system and subsystems levels. The objective of this paper is to summarize, for the larger Community of Practice, the initial set of Guidance, Navigation and Control (GN&C) engineering Best Practices as identified by this NESC assessment process.

GN&C Engineering Best Practices For Human-Rated Spacecraft Systems

NASA Technical Reports Server (NTRS)

Dennehy, Cornelius J.; Lebsock, Kenneth; West, John

2007-01-01

The NASA Engineering and Safety Center (NESC) recently completed an in-depth assessment to identify a comprehensive set of engineering considerations for the Design, Development, Test and Evaluation (DDT&E) of safe and reliable human-rated spacecraft systems. Reliability subject matter experts, discipline experts, and systems engineering experts were brought together to synthesize the current "best practices" both at the spacecraft system and subsystems levels. The objective of this paper is to summarize, for the larger Community of Practice, the initial set of Guidance, Navigation and Control (GN&C) engineering Best Practices as identified by this NESC assessment process.

Braking System for Wind Turbines

NASA Technical Reports Server (NTRS)

Krysiak, J. E.; Webb, F. E.

1987-01-01

Operating turbine stopped smoothly by fail-safe mechanism. Windturbine braking systems improved by system consisting of two large steel-alloy disks mounted on high-speed shaft of gear box, and brakepad assembly mounted on bracket fastened to top of gear box. Lever arms (with brake pads) actuated by spring-powered, pneumatic cylinders connected to these arms. Springs give specific spring-loading constant and exert predetermined load onto brake pads through lever arms. Pneumatic cylinders actuated positively to compress springs and disengage brake pads from disks. During power failure, brakes automatically lock onto disks, producing highly reliable, fail-safe stops. System doubles as stopping brake and "parking" brake.

If nuclear energy is the answer, why doesn't everyone agree?

NASA Astrophysics Data System (ADS)

Roberts, J. W.

2018-03-01

Nuclear energy produces low carbon, safe and reliable electricity so is it now time for the UK to invest in this proven technology or are the misplaced perceptions regarding its safety, cost and the quantities of radioactive waste produced causing us to overlook nuclear as a major component of our electricity mix? This paper discusses these issues and whether the negative opinion of nuclear energy which could hold back it’s wider development in the UK, is justified in the 21st century. For the safe, secure and economic future of electricity can we afford to ignore the positive contributions nuclear energy can make any longer?

Widely tunable gas laser for remote sensing

NASA Technical Reports Server (NTRS)

Rothe, D. E.

1988-01-01

An advanced, highly efficient and reliable Rare-Gas Halide laser was developed. It employs the following: (1) novel prepulse techniques and impedance matching for efficient energy transfer; (2) magnetic switches for high reliability; (3) x-ray preionization for discharge uniformity and beam quality; and (4) an integrated gas flow loop for compactness. When operated as a XeCl laser, the unit produces 2 J per pulse with good beam uniformity. Optical pulse duration is 100 ns. Pulse repetition rate was tested up to 25 Hz. Efficiency is 3 percent.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cadwallader, Lee C.; Zhao, Haihua

In this study, selected accident case histories are described that illustrate the potential modes of injury from gas jets, pressure-driven missiles, and asphyxiants. Gas combustion hazards are also briefly mentioned. Using high-pressure helium and nitrogen, estimates of safe exclusion distances are calculated for differing pressures, temperatures, and breach sizes. Some sources for gas system reliability values are also cited.

Benefits for Health; NASA

NASA Technical Reports Server (NTRS)

Perchonok, Michele

2014-01-01

The goal of HRP is to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. Presentation discusses (1) Bone Health: Vitamin D, Fish Consumption and Exercise (2) Medical Support in Remote Areas (3) ISS Ultrasound 4) Dry electrode EKG System (5) Environmental Factors and Psychological Health.

NDE: A key to engine rotor life prediction

NASA Technical Reports Server (NTRS)

Doherty, J. E.

1977-01-01

A key ingredient in the establishment of safe life times for critical components is the means of reliably detecting flaws which may potentially exist. Currently used nondestructive evaluation procedures are successful in detecting life limiting defects; however, the development of automated and computer aided NDE technology permits even greater assurance of flight safety.

77 FR 39987 - Arapaho and Roosevelt National Forests and Pawnee National Grassland; Boulder and Gilpin County...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... expectations for a safe, quality, recreational experience by providing appropriate lifts, terrain, and guest... reliability of lift and terrain offerings; (2) address skier safety concerns during prevalent wind events; (3...; (4) provide new and upgraded lift infrastructure to improve the quality of the alpine ski experience...

Is It Safe? Reliability and Validity of Structured versus Unstructured Child Safety Judgments

ERIC Educational Resources Information Center

Bartelink, Cora; de Kwaadsteniet, Leontien; ten Berge, Ingrid J.; Witteman, Cilia L. M.

2017-01-01

Background: The LIRIK, an instrument for the assessment of child safety and risk, is designed to improve assessments by guiding professionals through a structured evaluation of relevant signs, risk factors, and protective factors. Objective: We aimed to assess the interrater agreement and the predictive validity of professionals' judgments made…

Information Assurance Alignment: A Study of Performance Impacts

ERIC Educational Resources Information Center

Ghezal, Said

2011-01-01

The positive effect on performance of the alignment between a business strategy and its different functional strategies has a wide support in the literature. As an emerging functional area, information assurance has come to play a strategic role by providing all departments and functions across an organization with a reliable, safe, and efficient…

Detecting Approaching Vehicles at Streets with No Traffic Control

ERIC Educational Resources Information Center

Emerson, Robert Wall; Sauerburger, Dona

2008-01-01

This study assessed the ability of people with visual impairments to reliably detect oncoming traffic at crossing situations with no traffic control. In at least one condition, the participants could not hear vehicles to afford a safe crossing time when sound levels were as quiet as possible. Significant predictors of detection accounted for a…

Ares Projects Office Progress Update

NASA Technical Reports Server (NTRS)

Vanhooser, Teresa

2007-01-01

NASA's Vision for Exploration requires a safe, reliable, affordable launch infrastructure capable of replacing the Space Shuttle for low Earth orbit transportation, as well as supporting the goal of returning humans to the moon. This presentation provides an overview of NASA's Constellation program and the Ares I and Ares V launch vehicles, including accomplishments and future work.

Development and Reliability of the Comprehensive Crisis Plan Checklist

ERIC Educational Resources Information Center

Aspiranti, Kathleen B.; Pelchar, Taylor K.; McCLeary, Daniel F.; Bain, Sherry K.; Foster, Lisa N.

2011-01-01

It is of vital importance that children are educated in a safe environment. Every school needs to have a well-developed crisis management document containing plans for prevention, intervention, and postvention. We developed the Comprehensive Crisis Plan Checklist (CCPC) to serve as a valuable tool that can be used to assist practitioners with…

ATD-1 ATM Technology Demonstration-1 and Integrated Scheduling

NASA Technical Reports Server (NTRS)

Quon, Leighton

2014-01-01

Enabling efficient arrivals for the NextGen Air Traffic Management System and developing a set of integrated decision support tools to reduce the high cognitive workload so that controllers are able to simultaneously achieve safe, efficient, and expedient operations at high traffic demand levels.

Stockpile stewardship past, present, and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Marvin L., E-mail: mladams@tamu.edu

2014-05-09

The U.S. National Academies released a report in 2012 on technical issues related to the Comprehensive Test Ban Treaty. One important question addressed therein is whether the U.S. could maintain a safe, secure, and reliable nuclear-weapons stockpile in the absence of nuclear-explosion testing. Here we discuss two main conclusions from the 2012 Academies report, which we paraphrase as follows: 1) Provided that sufficient resources and a national commitment to stockpile stewardship are in place, the U.S. has the technical capabilities to maintain a safe, secure, and reliable stockpile of nuclear weapons into the foreseeable future without nuclear-explosion testing. 2) Doingmore » this would require: a) a strong weapons science and engineering program that addresses gaps in understanding; b) an outstanding workforce that applies deep and broad weapons expertise to deliver solutions to stockpile problems; c) a vigorous, stable surveillance program that delivers the requisite data; d) production facilities that meet stewardship needs. We emphasize that these conclusions are independent of CTBT ratification-they apply provided only that the U.S. continues its nuclear-explosion moratorium.« less

Novel LLM series high density energy materials: Synthesis, characterization, and thermal stability

NASA Astrophysics Data System (ADS)

Pagoria, Philip; Zhang, Maoxi; Tsyshevskiy, Roman; Kuklja, Maija

Novel high density energy materials must satisfy specific requirements, such as an increased performance, reliably high stability to external stimuli, cost-efficiency and ease of synthesis, be environmentally benign, and be safe for handling and transportation. During the last decade, the attention of researchers has drifted from widely used nitroester-, nitramine-, and nitroaromatic-based explosives to nitrogen-rich heterocyclic compounds. Good thermal stability, the low melting point, high density, and moderate sensitivity make heterocycle materials attractive candidates for use as oxidizers in rocket propellants and fuels, secondary explosives, and possibly as melt-castable ingredients of high explosive formulations. In this report, the synthesis, characterization, and results of quantum-chemical DFT study of thermal stability of LLM-191, LLM-192 and LLM-200 high density energy materials are presented. Work performed under the auspices of the DOE by the LLNL (Contract DE-AC52-07NA27344). This research is supported in part by ONR (Grant N00014-12-1-0529) and NSF. We used NSF XSEDE (Grant DMR-130077) and DOE NERSC (Contract DE-AC02-05CH11231) resources.

Finite volume method and multigrid acceleration in modelling of rapid crack propagation in full-scale pipe test

NASA Astrophysics Data System (ADS)

Ivankovic, A.; Muzaferija, S.; Demirdzic, I.

1997-07-01

Rapid Crack Propagation (RCP) along pressurised plastic pipes is by far the most dangerous pipe failure mode. Despite the economic benefits offered by increasing pipe size and operating pressure, both strategies increase the risk and the potential consequences of RCP. It is therefore extremely important to account for RCP in establishing the safe operational conditions. Combined experimental-numerical study is the only reliable approach of addressing the problem, and extensive research is undertaken by various fracture groups (e.g. Southwest Research Institute - USA, Imperial College - UK). This paper presents numerical results from finite volume modelling of full-scale test on medium density polyethylene gas pressurised pipes. The crack speed and pressure profile are prescribed in the analysis. Both steady-state and transient RCPs are considered, and the comparison between the two shown. The steady-state results are efficiently achieved employing a full multigrid acceleration technique, where sets of progressively finer grids are used in V-cycles. Also, the effect of inelastic behaviour of polyethylene on RCP results is demonstrated.

Refinements in the Design of the Ares V Cargo Launch Vehicle for NASA's, Exploration Strategy

NASA Technical Reports Server (NTRS)

Creech, Steve

2008-01-01

NASA is developing a new launch vehicle fleet to fulfill the national goals of replacing the shuttle fleet, completing the International Space Station (ISS), and exploring the Moon on the way to eventual exploration of Mars and beyond. Programmatic and technical decisions during early architecture studies and subsequent design activities were focused on safe, reliable operationally efficient vehicles that could support a sustainable exploration program. A pair of launch vehicles was selected to support those goals the Ares I crew launch vehicle and the Ares V cargo launch vehicle. They will be the first new human-rated launch vehicles developed by NASA in more than 30 years (Figure 1). Ares I will be the first to fly, beginning space station ferry operations no later than 2015. It will be able to carry up to six astronauts to ISS or support up to four astronauts for expeditions to the moon. Ares V is scheduled to be operational in the 2020 timeframe and will provide the propulsion systems and payload to truly extend human exploration beyond low-Earth orbit. (LEO).

Genome editing in plants: Advancing crop transformation and overview of tools.

PubMed

Shah, Tariq; Andleeb, Tayyaba; Lateef, Sadia; Noor, Mehmood Ali

2018-05-07

Genome manipulation technology is one of emerging field which brings real revolution in genetic engineering and biotechnology. Targeted editing of genomes pave path to address a wide range of goals not only to improve quality and productivity of crops but also permit to investigate the fundamental roots of biological systems. These goals includes creation of plants with valued compositional properties and with characters that confer resistance to numerous biotic and abiotic stresses. Numerous novel genome editing systems have been introduced during the past few years; these comprise zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9). Genome editing technique is consistent for improving average yield to achieve the growing demands of the world's existing food famine and to launch a feasible and environmentally safe agriculture scheme, to more specific, productive, cost-effective and eco-friendly. These exciting novel methods, concisely reviewed herein, have verified themselves as efficient and reliable tools for the genetic improvement of plants. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Investigation of a Verification and Validation Tool with a Turbofan Aircraft Engine Application

NASA Technical Reports Server (NTRS)

Uth, Peter; Narang-Siddarth, Anshu; Wong, Edmond

2018-01-01

The development of more advanced control architectures for turbofan aircraft engines can yield gains in performance and efficiency over the lifetime of an engine. However, the implementation of these increasingly complex controllers is contingent on their ability to provide safe, reliable engine operation. Therefore, having the means to verify the safety of new control algorithms is crucial. As a step towards this goal, CoCoSim, a publicly available verification tool for Simulink, is used to analyze C-MAPSS40k, a 40,000 lbf class turbo-fan engine model developed at NASA for testing new control algorithms. Due to current limitations of the verification software, several modifications are made to C-MAPSS40k to achieve compatibility with CoCoSim. Some of these modifications sacrifice fidelity to the original model. Several safety and performance requirements typical for turbofan engines are identified and constructed into a verification framework. Preliminary results using an industry standard baseline controller for these requirements are presented. While verification capabilities are demonstrated, a truly comprehensive analysis will require further development of the verification tool.

Phytoextraction of Cd-Contaminated Soils: Current Status and Future Challenges.

PubMed

Li, Jin-Tian; Baker, Alan J M; Ye, Zhi-Hong; Wang, Hong-Bin; Shu, Wen-Sheng

2012-10-01

Cadmium (Cd) is one of the most toxic and widely distributed pollutants in the environment. Cadmium contamination of soils has posed a serious threat to safe food production in many parts of the world. The authors present a comprehensive review of present status of phytoextraction technology for cleaning up Cd-contaminated soils, based primarily on the data resulting from both laboratory and field-scale studies that have been conducted to assess or improve the Cd phytoextraction potential of various plant species in the past decade. The encouraging results of field-scale studies have provided a fundamental basis to usher phytoextraction technology into practical use to remediate slightly to moderately Cd-contaminated soils in Europe and Asia, although this technology is not yet ready for widespread application. Chelators and microorganisms tested so far seem not to contribute to the applicability of Cd phytoextraction. The major challenges for the large-scale application of Cd phytoextraction are (a) how to further improve the efficiency of Cd phytoextraction, (b) how to cut the overall costs of Cd phytoextraction, and (c) how to get greater stakeholders' acceptance of Cd phytoextraction as a reliable option.

The Fuel Cell Powered Club Car Carryall

NASA Technical Reports Server (NTRS)

Eichenberg, Dennis J.

2005-01-01

The NASA Glenn Research Center initiated development of the Fuel Cell Powered Club Car Carryall as a way to reduce pollution in industrial settings, reduce fossil fuel consumption and reduce operating costs for transportation systems. The Club Car Carryall provides an inexpensive approach to advance the state of the art in electric vehicle technology in a practical application. The project transfers space technology to terrestrial use via non-traditional partners, and provides power system data valuable for future aeronautics and space applications. The work was done under the Hybrid Power Management (HPM) Program. The Carryall is a state of the art, dedicated, electric utility vehicle. Hydrogen powered proton exchange membrane (PEM) fuel cells are the primary power source. Ultracapacitors were used for energy storage as long life, maintenance free operation, and excellent low temperature performance is essential. Metal hydride hydrogen storage was used to store hydrogen in a safe and efficient low-pressure solid form. The report concludes that the Fuel Cell Powered Club Car Carryall can provide excellent performance, and that the implementation of fuel cells in conjunction with ultracapacitors in the power system can provide significant reliability and performance improvements.

Design of lithium cobalt oxide electrodes with high thermal conductivity and electrochemical performance using carbon nanotubes and diamond particles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Eungje; Salgado, Ruben Arash; Lee, Byeongdu

Thermal management remains one of the major challenges in the design of safe and reliable Li-ion batteries. We show that composite electrodes assembled from commercially available 100 μm long carbon nanotubes (CNTs) and LiCoO2 (LCO) particles demonstrate the in-plane thermal conductivity of 205.8 W/m*K. This value exceeds the thermal conductivity of dry conventional laminated electrodes by about three orders of magnitude. The cross-plane thermal conductivity of CNT-based electrodes is in the same range as thermal conductivities of conventional laminated electrodes. The CNT-based electrodes demonstrate a similar capacity to conventional laminated design electrodes, but revealed a better rate performance and stability.more » The introduction of diamond particles into CNT-based electrodes further improves the rate performance. Our lightweight, flexible electrode design can potentially be a general platform for fabricating polymer binder- and aluminum and copper current collector- free electrodes from a broad range of electrochemically active materials with efficient thermal management.« less

Multivariate Analysis for Quantification of Plutonium(IV) in Nitric Acid Based on Absorption Spectra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lines, Amanda M.; Adami, Susan R.; Sinkov, Sergey I.

Development of more effective, reliable, and fast methods for monitoring process streams is a growing opportunity for analytical applications. Many fields can benefit from on-line monitoring, including the nuclear fuel cycle where improved methods for monitoring radioactive materials will facilitate maintenance of proper safeguards and ensure safe and efficient processing of materials. On-line process monitoring with a focus on optical spectroscopy can provide a fast, non-destructive method for monitoring chemical species. However, identification and quantification of species can be hindered by the complexity of the solutions if bands overlap or show condition-dependent spectral features. Plutonium (IV) is one example ofmore » a species which displays significant spectral variation with changing nitric acid concentration. Single variate analysis (i.e. Beer’s Law) is difficult to apply to the quantification of Pu(IV) unless the nitric acid concentration is known and separate calibration curves have been made for all possible acid strengths. Multivariate, or chemometric, analysis is an approach that allows for the accurate quantification of Pu(IV) without a priori knowledge of nitric acid concentration.« less

Biogeography-based combinatorial strategy for efficient autonomous underwater vehicle motion planning and task-time management

NASA Astrophysics Data System (ADS)

Zadeh, S. M.; Powers, D. M. W.; Sammut, K.; Yazdani, A. M.

2016-12-01

Autonomous Underwater Vehicles (AUVs) are capable of spending long periods of time for carrying out various underwater missions and marine tasks. In this paper, a novel conflict-free motion planning framework is introduced to enhance underwater vehicle's mission performance by completing maximum number of highest priority tasks in a limited time through a large scale waypoint cluttered operating field, and ensuring safe deployment during the mission. The proposed combinatorial route-path planner model takes the advantages of the Biogeography-Based Optimization (BBO) algorithm toward satisfying objectives of both higher-lower level motion planners and guarantees maximization of the mission productivity for a single vehicle operation. The performance of the model is investigated under different scenarios including the particular cost constraints in time-varying operating fields. To show the reliability of the proposed model, performance of each motion planner assessed separately and then statistical analysis is undertaken to evaluate the total performance of the entire model. The simulation results indicate the stability of the contributed model and its feasible application for real experiments.

Applications of fuzzy logic to control and decision making

NASA Technical Reports Server (NTRS)

Lea, Robert N.; Jani, Yashvant

1991-01-01

Long range space missions will require high operational efficiency as well as autonomy to enhance the effectivity of performance. Fuzzy logic technology has been shown to be powerful and robust in interpreting imprecise measurements and generating appropriate control decisions for many space operations. Several applications are underway, studying the fuzzy logic approach to solving control and decision making problems. Fuzzy logic algorithms for relative motion and attitude control have been developed and demonstrated for proximity operations. Based on this experience, motion control algorithms that include obstacle avoidance were developed for a Mars Rover prototype for maneuvering during the sample collection process. A concept of an intelligent sensor system that can identify objects and track them continuously and learn from its environment is under development to support traffic management and proximity operations around the Space Station Freedom. For safe and reliable operation of Lunar/Mars based crew quarters, high speed controllers with ability to combine imprecise measurements from several sensors is required. A fuzzy logic approach that uses high speed fuzzy hardware chips is being studied.

Heliospheric Physics and NASA's Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Minow, Joseph I.

2007-01-01

The Vision for Space Exploration outlines NASA's development of a new generation of human-rated launch vehicles to replace the Space Shuttle and an architecture for exploring the Moon and Mars. The system--developed by the Constellation Program--includes a near term (approx. 2014) capability to provide crew and cargo service to the International Space Station after the Shuttle is retired in 2010 and a human return to the Moon no later than 2020. Constellation vehicles and systems will necessarily be required to operate efficiently, safely, and reliably in the space plasma and radiation environments of low Earth orbit, the Earth's magnetosphere, interplanetary space, and on the lunar surface. This presentation will provide an overview of the characteristics of space radiation and plasma environments relevant to lunar programs including the trans-lunar injection and trans-Earth injection trajectories through the Earth's radiation belts, solar wind surface dose and plasma wake charging environments in near lunar space, energetic solar particle events, and galactic cosmic rays and discusses the design and operational environments being developed for lunar program requirements to assure that systems operate successfully in the space environment.

High power diode lasers emitting from 639 nm to 690 nm

NASA Astrophysics Data System (ADS)

Bao, L.; Grimshaw, M.; DeVito, M.; Kanskar, M.; Dong, W.; Guan, X.; Zhang, S.; Patterson, J.; Dickerson, P.; Kennedy, K.; Li, S.; Haden, J.; Martinsen, R.

2014-03-01

There is increasing market demand for high power reliable red lasers for display and cinema applications. Due to the fundamental material system limit at this wavelength range, red diode lasers have lower efficiency and are more temperature sensitive, compared to 790-980 nm diode lasers. In terms of reliability, red lasers are also more sensitive to catastrophic optical mirror damage (COMD) due to the higher photon energy. Thus developing higher power-reliable red lasers is very challenging. This paper will present nLIGHT's released red products from 639 nm to 690nm, with established high performance and long-term reliability. These single emitter diode lasers can work as stand-alone singleemitter units or efficiently integrate into our compact, passively-cooled Pearl™ fiber-coupled module architectures for higher output power and improved reliability. In order to further improve power and reliability, new chip optimizations have been focused on improving epitaxial design/growth, chip configuration/processing and optical facet passivation. Initial optimization has demonstrated promising results for 639 nm diode lasers to be reliably rated at 1.5 W and 690nm diode lasers to be reliably rated at 4.0 W. Accelerated life-test has started and further design optimization are underway.

Mobile agent application and integration in electronic anamnesis system.

PubMed

Liu, Chia-Hui; Chung, Yu-Fang; Chen, Tzer-Shyong; Wang, Sheng-De

2012-06-01

Electronic anamnesis is to transform ordinary paper trails to digitally formatted health records, which include the patient's general information, health status, and follow-ups on chronic diseases. Its main purpose is to let the records could be stored for a longer period of time and could be shared easily across departments and hospitals. Which means hospital management could use less resource on maintaining ever-growing database and reduce redundancy, so less money would be spent for managing the health records. In the foreseeable future, building up a comprehensive and integrated medical information system is a must, because it is critical to hospital resource integration and quality improvement. If mobile agent technology is adopted in the electronic anamnesis system, it would help the hospitals to make the medical practices more efficiently and conveniently. Nonetheless, most of the hospitals today are still using paper-based health records to manage the medical information. The reason why the institutions continue using traditional practices to manage the records is because there is no well-trusted and reliable electronic anamnesis system existing and accepted by both institutions and patients. The threat of privacy invasion is one of the biggest concerns when the topic of electronic anamnesis is brought up, because the security threats drag us back from using such a system. So, the medical service quality is difficult to be improved substantially. In this case, we have come up a theory to remove such security threats and make electronic anamnesis more appealing for use. Our theory is to integrate the mobile agent technology with the backbone of electronic anamnesis to construct a hierarchical access control system to retrieve the corresponding information based upon the permission classes. The system would create a classification for permission among the users inside the medical institution. Under this framework, permission control center would distribute an access key to each user, so they would only allow using the key to access information correspondingly. In order to verify the reliability of the proposed system framework, we have also conducted a security analysis to list all the possible security threats that may harm the system and to prove the system is reliable and safe. If the system is adopted, the doctors would be able to quickly access the information while performing medical examinations. Hence, the efficiency and quality of healthcare service would be greatly improved.

Development and Testing of the Glenn Research Center Visitor's Center Grid-Tied Photovoltaic Power System

NASA Technical Reports Server (NTRS)

Eichenberg, Dennis J.

2009-01-01

The NASA Glenn Research Center (GRC) has developed, installed, and tested a 12 kW DC grid-tied photovoltaic (PV) power system at the GRC Visitor s Center. This system utilizes a unique ballast type roof mount for installing the photovoltaic panels on the roof of the Visitor s Center with no alterations or penetrations to the roof. The PV system has generated in excess of 15000 kWh since operation commenced in August 2008. The PV system is providing power to the GRC grid for use by all. Operation of the GRC Visitor s Center PV system has been completely trouble free. A grid-tied PV power system is connected directly to the utility distribution grid. Facility power can be obtained from the utility system as normal. The PV system is synchronized with the utility system to provide power for the facility, and excess power is provided to the utility. The project transfers space technology to terrestrial use via nontraditional partners. GRC personnel glean valuable experience with PV power systems that are directly applicable to various space power systems, and provides valuable space program test data. PV power systems help to reduce harmful emissions and reduce the Nation s dependence on fossil fuels. Power generated by the PV system reduces the GRC utility demand, and the surplus power aids the community. Present global energy concerns reinforce the need for the development of alternative energy systems. Modern PV panels are readily available, reliable, efficient, and economical with a life expectancy of at least 25 years. Modern electronics has been the enabling technology behind grid-tied power systems, making them safe, reliable, efficient, and economical with a life expectancy of at least 25 years. Based upon the success of the GRC Visitor s Center PV system, additional PV power system expansion at GRC is under consideration. The GRC Visitor s Center grid-tied PV power system was successfully designed and developed which served to validate the basic principles described, and the theoretical work that was performed. The report concludes that grid-tied photovoltaic power systems are reliable, maintenance free, long life power systems, and are of significant value to NASA and the community.

A Comparison of Three Multivariate Models for Estimating Test Battery Reliability.

ERIC Educational Resources Information Center

Wood, Terry M.; Safrit, Margaret J.

1987-01-01

A comparison of three multivariate models (canonical reliability model, maximum generalizability model, canonical correlation model) for estimating test battery reliability indicated that the maximum generalizability model showed the least degree of bias, smallest errors in estimation, and the greatest relative efficiency across all experimental…

Assessing the microbial quality of improved drinking water sources: results from the Dominican Republic.

PubMed

Baum, Rachel; Kayser, Georgia; Stauber, Christine; Sobsey, Mark

2014-01-01

Millennium Development Goal Target 7c (to halve between 1990 and 2015 the proportion of the global population without sustainable access to safe drinking water), was celebrated as achieved in 2012. However, new studies show that we may be prematurely celebrating. Access to safe drinking water may be overestimated if microbial water quality is considered. The objective of this study was to examine the relationship between microbial drinking water quality and drinking water source in the Puerto Plata region of the Dominican Republic. This study analyzed microbial drinking water quality data from 409 households in 33 communities. Results showed that 47% of improved drinking water sources were of high to very-high risk water quality, and therefore unsafe for drinking. This study provides evidence that the current estimate of safe water access may be overly optimistic, and microbial water quality data are needed to reliably assess the safety of drinking water.

The application of multilayer elastic beam in MEMS safe and arming system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Guozhong, E-mail: liguozhong-bit@bit.edu.cn; Shi, Gengchen; Sui, Li

In this paper, a new approach for a multilayer elastic beam to provide a driving force and driving distance for a MEMS safe and arming system is presented. In particular this is applied where a monolayer elastic beam cannot provide adequate driving force and driving distance at the same time in limited space. Compared with thicker elastic beams, the bilayer elastic beam can provide twice the driving force of a monolayer beam to guarantee the MEMS safe and arming systems work reliably without decreasing the driving distance. In this paper, the theoretical analysis, numerical simulation and experimental verification of themore » multilayer elastic beam is presented. The numerical simulation and experimental results show that the bilayer elastic provides 1.8–2 times the driving force of a monolayer, and a method that improves driving force without reducing the driving distance.« less

Assessing the Microbial Quality of Improved Drinking Water Sources: Results from the Dominican Republic

PubMed Central

Baum, Rachel; Kayser, Georgia; Stauber, Christine; Sobsey, Mark

2014-01-01

Millennium Development Goal Target 7c (to halve between 1990 and 2015 the proportion of the global population without sustainable access to safe drinking water), was celebrated as achieved in 2012. However, new studies show that we may be prematurely celebrating. Access to safe drinking water may be overestimated if microbial water quality is considered. The objective of this study was to examine the relationship between microbial drinking water quality and drinking water source in the Puerto Plata region of the Dominican Republic. This study analyzed microbial drinking water quality data from 409 households in 33 communities. Results showed that 47% of improved drinking water sources were of high to very-high risk water quality, and therefore unsafe for drinking. This study provides evidence that the current estimate of safe water access may be overly optimistic, and microbial water quality data are needed to reliably assess the safety of drinking water. PMID:24218411

Is VATS lobectomy standard of care for operable non-small cell lung cancer?

PubMed

Vannucci, Fernando; Gonzalez-Rivas, Diego

2016-10-01

Video-Assisted Thoracic Surgery (VATS) for treatment of lung cancer is being increasingly applied worldwide in the last few years. Since its introduction, many publications have been providing strong evidences that this minimally invasive approach is feasible, safe and oncologically efficient; offering to patients several advantages over traditional open thoracotomy, particularly for early-stage disease (I and II). The application of VATS for locally advanced disease treatment has also been largely described, but probably requires a further level of experience, which is more likely to be found in reference centers, with skilled experts. Although a large multi-institutional prospective randomized-controlled trial is the best way to confirm the superiority of one technique over another, such study comparing VATS versus open lobectomy for lung cancer is unlikely to ever come out. And in this scenario, retrospective data remains as the most reliable source of scientific information. Based on a literature review, the main objective of this article is to discuss to what extent VATS lobectomy can be considered the gold standard in the surgical treatment of lung cancer, taking into account the most important comparison aspects between the minimally invasive approach and open thoracotomy technique. This review addresses questions regarding lymph node dissection, oncologic efficacy, extended resections beyond standard lobectomy, post-operative complications/pain/quality of life, survival rates and the present limits of indication (and contraindication) for VATS, in order to define the real role of this technique on the surgical treatment of lung cancer in a minimally invasive, but safe and effective manner. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

An Automated Method to Compute Orbital Re-entry Trajectories with Heating Constraints

NASA Technical Reports Server (NTRS)

Zimmerman, Curtis; Dukeman, Greg; Hanson, John; Fogle, Frank R. (Technical Monitor)

2002-01-01

Determining how to properly manipulate the controls of a re-entering re-usable launch vehicle (RLV) so that it is able to safely return to Earth and land involves the solution of a two-point boundary value problem (TPBVP). This problem, which can be quite difficult, is traditionally solved on the ground prior to flight. If necessary, a nearly unlimited amount of time is available to find the 'best' solution using a variety of trajectory design and optimization tools. The role of entry guidance during flight is to follow the pre- determined reference solution while correcting for any errors encountered along the way. This guidance method is both highly reliable and very efficient in terms of onboard computer resources. There is a growing interest in a style of entry guidance that places the responsibility of solving the TPBVP in the actual entry guidance flight software. Here there is very limited computer time. The powerful, but finicky, mathematical tools used by trajectory designers on the ground cannot in general be converted to do the job. Non-convergence or slow convergence can result in disaster. The challenges of designing such an algorithm are numerous and difficult. Yet the payoff (in the form of decreased operational costs and increased safety) can be substantiaL This paper presents an algorithm that incorporates features of both types of guidance strategies. It takes an initial RLV orbital re-entry state and finds a trajectory that will safely transport the vehicle to Earth. During actual flight, the computed trajectory is used as the reference to be flown by a more traditional guidance method.

MO-D-BRB-02: SBRT Treatment Planning and Delivery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Y.

2016-06-15

Increased use of SBRT and hypofractionation in radiation oncology practice has posted a number of challenges to medical physicist, ranging from planning, image-guided patient setup and on-treatment monitoring, to quality assurance (QA) and dose delivery. This symposium is designed to provide current knowledge necessary for the safe and efficient implementation of SBRT in various linac platforms, including the emerging digital linacs equipped with high dose rate FFF beams. Issues related to 4D CT, PET and MRI simulations, 3D/4D CBCT guided patient setup, real-time image guidance during SBRT dose delivery using gated/un-gated VMAT/IMRT, and technical advancements in QA of SBRT (inmore » particular, strategies dealing with high dose rate FFF beams) will be addressed. The symposium will help the attendees to gain a comprehensive understanding of the SBRT workflow and facilitate their clinical implementation of the state-of-art imaging and planning techniques. Learning Objectives: Present background knowledge of SBRT, describe essential requirements for safe implementation of SBRT, and discuss issues specific to SBRT treatment planning and QA. Update on the use of multi-dimensional and multi-modality imaging for reliable guidance of SBRT. Discuss treatment planning and QA issues specific to SBRT. Provide a comprehensive overview of emerging digital linacs and summarize the key geometric and dosimetric features of the new generation of linacs for substantially improved SBRT. NIH/NCI; Varian Medical Systems; F. Yin, Duke University has a research agreement with Varian Medical Systems. In addition to research grant, I had a technology license agreement with Varian Medical Systems.« less

[Implementation of "5S" methodology in laboratory safety and its effect on employee satisfaction].

PubMed

Dogan, Yavuz; Ozkutuk, Aydan; Dogan, Ozlem

2014-04-01

Health institutions use the accreditation process to achieve improvement across the organization and management of the health care system. An ISO 15189 quality and efficiency standard is the recommended standard for medical laboratories qualification. The "safety and accommodation conditions" of this standard covers the requirement to improve working conditions and maintain the necessary safety precautions. The most inevitable precaution for ensuring a safe environment is the creation of a clean and orderly environment to maintain a potentially safe surroundings. In this context, the 5S application which is a superior improvement tool that has been used by the industry, includes some advantages such as encouraging employees to participate in and to help increase the productivity. The main target of this study was to implement 5S methods in a clinical laboratory of a university hospital for evaluating its effect on employees' satisfaction, and correction of non-compliance in terms of the working environment. To start with, first, 5S education was given to management and employees. Secondly, a 5S team was formed and then the main steps of 5S (Seiri: Sort, Seiton: Set in order, Seiso: Shine, Seiketsu: Standardize, and Shitsuke: Systematize) were implemented for a duration of 3 months. A five-point likert scale questionnaire was used in order to determine and assess the impact of 5S on employees' satisfaction considering the areas such as facilitating the job, the job satisfaction, setting up a safe environment, and the effect of participation in management. Questionnaire form was given to 114 employees who actively worked during the 5S implementation period, and the data obtained from 63 (52.3%) participants (16 male, 47 female) were evaluated. The reliability of the questionnaire's Cronbach's alpha value was determined as 0.858 (p< 0.001). After the implementation of 5S it was observed and determined that facilitating the job and setting up a safe environment created a statistically significant effect on employees, and some sufficient satisfaction was observed. In addition, the non-conformity score, which was identified in the laboratory during the previous years, was significantly reduced at a rate of 69.7% after the implementation of 5S. 5S practices have successfully contributed to the establishment and to the sustainability of laboratory safety systems in the first public ISO 15189 accredited public clinical laboratory in Turkey. It is concluded that 5S methods can be used as an effective improvement tool in order to maintain a safe environment, to facilitate the job, and to encourage employees to participate in the management process.

Electricity and generator availability in LMIC hospitals: improving access to safe surgery.

PubMed

Chawla, Sagar; Kurani, Shaheen; Wren, Sherry M; Stewart, Barclay; Burnham, Gilbert; Kushner, Adam; McIntyre, Thomas

2018-03-01

Access to reliable energy has been identified as a global priority and codified within United Nations Sustainable Goal 7 and the Electrify Africa Act of 2015. Reliable hospital access to electricity is necessary to provide safe surgical care. The current state of electrical availability in hospitals in low- and middle-income countries (LMICs) throughout the world is not well known. This study aimed to review the surgical capacity literature and document the availability of electricity and generators. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search for surgical capacity assessments in LMICs in MEDLINE, PubMed, and World Health Organization Global Health Library was performed. Data regarding electricity and generator availability were extracted. Estimated percentages for individual countries were calculated. Of 76 articles identified, 21 reported electricity availability, totaling 528 hospitals. Continuous electricity availability at hospitals providing surgical care was 312/528 (59.1%). Generator availability was 309/427 (72.4%). Estimated continuous electricity availability ranged from 0% (Sierra Leone and Malawi) to 100% (Iran); estimated generator availability was 14% (Somalia) to 97.6% (Iran). Less than two-thirds of hospitals providing surgical care in 21 LMICs have a continuous electricity source or have an available generator. Efforts are needed to improve electricity infrastructure at hospitals to assure safe surgical care. Future research should look at the effect of energy availability on surgical care and patient outcomes and novel methods of powering surgical equipment. Copyright © 2017 Elsevier Inc. All rights reserved.

Cast Coil Transformer Fire Susceptibility and Reliability Study

DTIC Science & Technology

1991-04-01

transformers reduce risk to the user compared to liquid-filled units, eliminate environmental impacts, are more efficient than most transformer designs, and...filled units, eliminate environmental impacts, arc more efficient than most transformer designs, and add minimal risk to the facility in a fire situation...add minimal risk to the facility in a fire situation. Cast coil transformers have a long record of operation and have proven to be reliable and

Highly-reliable operation of 638-nm broad stripe laser diode with high wall-plug efficiency for display applications

NASA Astrophysics Data System (ADS)

Yagi, Tetsuya; Shimada, Naoyuki; Nishida, Takehiro; Mitsuyama, Hiroshi; Miyashita, Motoharu

2013-03-01

Laser based displays, as pico to cinema laser projectors have gathered much attention because of wide gamut, low power consumption, and so on. Laser light sources for the displays are operated mainly in CW, and heat management is one of the big issues. Therefore, highly efficient operation is necessitated. Also the light sources for the displays are requested to be highly reliable. 638 nm broad stripe laser diode (LD) was newly developed for high efficiency and highly reliable operation. An AlGaInP/GaAs red LD suffers from low wall plug efficiency (WPE) due to electron overflow from an active layer to a p-cladding layer. Large optical confinement factor (Γ) design with AlInP cladding layers is adopted to improve the WPE. The design has a disadvantage for reliable operation because the large Γ causes high optical density and brings a catastrophic optical degradation (COD) at a front facet. To overcome the disadvantage, a window-mirror structure is also adopted in the LD. The LD shows WPE of 35% at 25°C, highest record in the world, and highly stable operation at 35°C, 550 mW up to 8,000 hours without any catastrophic optical degradation.

A novel liquid organic hydrogen carrier system based on catalytic peptide formation and hydrogenation

PubMed Central

Hu, Peng; Fogler, Eran; Diskin-Posner, Yael; Iron, Mark A.; Milstein, David

2015-01-01

Hydrogen is an efficient green fuel, but its low energy density when stored under high pressure or cryogenically, and safety issues, presents significant disadvantages; hence finding efficient and safe hydrogen carriers is a major challenge. Of special interest are liquid organic hydrogen carriers (LOHCs), which can be readily loaded and unloaded with considerable amounts of hydrogen. However, disadvantages include high hydrogen pressure requirements, high reaction temperatures for both hydrogenation and dehydrogenation steps, which require different catalysts, and high LOHC cost. Here we present a readily reversible LOHC system based on catalytic peptide formation and hydrogenation, using an inexpensive, safe and abundant organic compound with high potential capacity to store and release hydrogen, applying the same catalyst for loading and unloading hydrogen under relatively mild conditions. Mechanistic insight of the catalytic reaction is provided. We believe that these findings may lead to the development of an inexpensive, safe and clean liquid hydrogen carrier system. PMID:25882348

Noncatalytic oxypyrolysis of C{sub 2+}-hydrocarbons from natural gas to ethylene and propylene in a most energy-efficient and safe manner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choudhary, V.R.; Mulla, S.A.R.; Rajput, A.M.

1997-06-01

Noncatalytic oxypyrolysis of C{sub 2+}-hydrocarbons from natural gas at 700--850 C in the presence of steam and limited oxygen yields ethylene and propylene with appreciable conversion and high selectivity but with almost no coke or tarlike product formation. In this process, the exothermic oxidative hydrocarbon conversion reactions are coupled directly with the endothermic cracking of C{sub 2+}-hydrocarbons by their simultaneous occurrence. Hence, the process operates in a most energy-efficient and safe (or nonhazardous) manner and also can be made almost thermoneutral or mildly endothermic/exothermic, thus requiring little or no external energy for the hydrocarbon conversion reactions.

Endocytosis and exocytosis of nanoparticles in mammalian cells

PubMed Central

Oh, Nuri; Park, Ji-Ho

2014-01-01

Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review the recent research on the endocytosis and exocytosis of functionalized nanoparticles based on various sizes, shapes, and surface chemistries. We believe that this review contributes to the design of safe nanoparticles that can efficiently enter and leave human cells and tissues. PMID:24872703

The Four Cs of Successful Classroom Management: The Music Educator's Job Is Easier if the Classroom Offers a Positive and Challenging Environment

ERIC Educational Resources Information Center

Reese, Jill

2007-01-01

The four Cs of classroom management--commendation, communication, consistency, and content--represent one of the quickest and most successful ways to establish a safe, healthful, and fun environment at any level, especially in elementary schools. Using the four Cs helps establish an efficient, supportive, and safe environment to nurture positive…

Safety and IVHM

NASA Technical Reports Server (NTRS)

Goebel, Kai

2012-01-01

When we address safety in a book on the business case for IVHM, the question arises whether safety isn t inherently in conflict with the need of operators to run their systems as efficiently (and as cost effectively) as possible. The answer may be that the system needs to be just as safe as needed, but not significantly more. That begs the next question: How safe is safe enough? Several regulatory bodies provide guidelines for operational safety, but irrespective of that, operators do not want their systems to be known as lacking safety. We illuminate the role of safety within the context of IVHM.

Autonomous, Decentralized Grid Architecture: Prosumer-Based Distributed Autonomous Cyber-Physical Architecture for Ultra-Reliable Green Electricity Networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2012-01-11

GENI Project: Georgia Tech is developing a decentralized, autonomous, internet-like control architecture and control software system for the electric power grid. Georgia Tech’s new architecture is based on the emerging concept of electricity prosumers—economically motivated actors that can produce, consume, or store electricity. Under Georgia Tech’s architecture, all of the actors in an energy system are empowered to offer associated energy services based on their capabilities. The actors achieve their sustainability, efficiency, reliability, and economic objectives, while contributing to system-wide reliability and efficiency goals. This is in marked contrast to the current one-way, centralized control paradigm.

Structural reliability analysis under evidence theory using the active learning kriging model

NASA Astrophysics Data System (ADS)

Yang, Xufeng; Liu, Yongshou; Ma, Panke

2017-11-01

Structural reliability analysis under evidence theory is investigated. It is rigorously proved that a surrogate model providing only correct sign prediction of the performance function can meet the accuracy requirement of evidence-theory-based reliability analysis. Accordingly, a method based on the active learning kriging model which only correctly predicts the sign of the performance function is proposed. Interval Monte Carlo simulation and a modified optimization method based on Karush-Kuhn-Tucker conditions are introduced to make the method more efficient in estimating the bounds of failure probability based on the kriging model. Four examples are investigated to demonstrate the efficiency and accuracy of the proposed method.

Microsurgical Bypass Training Rat Model, Part 1: Technical Nuances of Exposure of the Aorta and Iliac Arteries.

PubMed

Tayebi Meybodi, Ali; Lawton, Michael T; Mokhtari, Pooneh; Yousef, Sonia; Gandhi, Sirin; Benet, Arnau

2017-11-01

Animal models using rodents are frequently used for practicing microvascular anastomosis-an essential technique in cerebrovascular surgery. However, safely and efficiently exposing rat's target vessels is technically difficult. Such difficulty may lead to excessive hemorrhage and shorten animal survival. This limits the ability to perform multiple anastomoses on a single animal and may increase the overall training time and costs. We report our model for microsurgical bypass training in rodents in 2 consecutive articles. In part 1, we describe the technical nuances for a safe and efficient exposure of the rat abdominal aorta and common iliac arteries (CIAs) for bypass. Over a 2-year period, 50 Sprague-Dawley rats underwent inhalant anesthesia for practicing microvascular anastomosis on the abdominal aorta and CIAs. Lessons learned regarding the technical nuances of vessel exposure were recorded. Several technical nuances were important for avoiding intraoperative bleeding and preventing animal demise while preparing an adequate length of vessels for bypass. The most relevant technical nuances include (1) generous subcutaneous dissection; (2) use of cotton swabs for the blunt dissection of the retroperitoneal fat; (3) combination of sharp and blunt dissection to isolate the aorta and iliac arteries from the accompanying veins; (4) proper control of the posterior branches of the aorta; and (5) efficient division and mobilization of the left renal pedicle. Applying the aforementioned technical nuances enables safe and efficient preparation of the rat abdominal aorta and CIAs for microvascular anastomosis. Copyright © 2017 Elsevier Inc. All rights reserved.

Reliability assessment of serviceability performance of braced retaining walls using a neural network approach

NASA Astrophysics Data System (ADS)

Goh, A. T. C.; Kulhawy, F. H.

2005-05-01

In urban environments, one major concern with deep excavations in soft clay is the potentially large ground deformations in and around the excavation. Excessive movements can damage adjacent buildings and utilities. There are many uncertainties associated with the calculation of the ultimate or serviceability performance of a braced excavation system. These include the variabilities of the loadings, geotechnical soil properties, and engineering and geometrical properties of the wall. A risk-based approach to serviceability performance failure is necessary to incorporate systematically the uncertainties associated with the various design parameters. This paper demonstrates the use of an integrated neural network-reliability method to assess the risk of serviceability failure through the calculation of the reliability index. By first performing a series of parametric studies using the finite element method and then approximating the non-linear limit state surface (the boundary separating the safe and failure domains) through a neural network model, the reliability index can be determined with the aid of a spreadsheet. Two illustrative examples are presented to show how the serviceability performance for braced excavation problems can be assessed using the reliability index.

Supporting the future nuclear workforce with computer-based procedures

DOE PAGES

Oxstrand, Johanna; Le Blanc, Katya

2016-05-01

Here we see that computer-based tools have dramatically increased ease and efficiency of everyday tasks. Gone are the days of paging through a paper catalog, transcribing product numbers, and calculating totals. Today, a consumer can find a product online with a simple search engine, and then purchase it in a matter of a few clicks. Paper catalogs have their place, but it is hard to imagine life without on-line shopping sites. All tasks conducted in a nuclear power plant are guided by procedures, which helps ensure safe and reliable operation of the plants. One prominent goal of the nuclear industrymore » is to minimize the risk of human errors. To achieve this goal one has to ensure tasks are correctly and consistently executed. This is partly achieved by training and by a structured approach to task execution, which is provided by procedures and work instructions. Procedures are used in the nuclear industry to direct workers' actions in a proper sequence. The governing idea is to minimize the reliance on memory and choices made in the field. However, the procedure document may not contain sufficient information to successfully complete the task. Therefore, the worker might have to carry additional documents such as turnover sheets, operation experience, drawings, and other procedures to the work site. The nuclear industry is operated with paper procedures like paper catalogs of the past. A field worker may carry a large stack of documents needed to complete a task to the field. Even though the paper process has helped keep the industry safe for decades, there are limitations to using paper. Paper procedures are static (i.e., the content does not change after the document is printed), difficult to search, and rely heavily on the field worker’s situational awareness and ability to consistently meet the high expectation of human performance excellence. With computer-based procedures (CBPs) that stack of papers may be reduced to the size of a small tablet or even a smart phone. Instead of manually matching equipment identification numbers listed in the procedure with the number on the physical equipment the field worker can simply scan a barcode to ensure the correct valve is opened while simultaneously creating a record. Instead of navigating through a maze of cross-references, CBPs enable intelligent work path navigation which accounts for past decisions and observation, thereby enabling more efficient and safe task completion.« less

Supporting the future nuclear workforce with computer-based procedures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oxstrand, Johanna; Le Blanc, Katya

Here we see that computer-based tools have dramatically increased ease and efficiency of everyday tasks. Gone are the days of paging through a paper catalog, transcribing product numbers, and calculating totals. Today, a consumer can find a product online with a simple search engine, and then purchase it in a matter of a few clicks. Paper catalogs have their place, but it is hard to imagine life without on-line shopping sites. All tasks conducted in a nuclear power plant are guided by procedures, which helps ensure safe and reliable operation of the plants. One prominent goal of the nuclear industrymore » is to minimize the risk of human errors. To achieve this goal one has to ensure tasks are correctly and consistently executed. This is partly achieved by training and by a structured approach to task execution, which is provided by procedures and work instructions. Procedures are used in the nuclear industry to direct workers' actions in a proper sequence. The governing idea is to minimize the reliance on memory and choices made in the field. However, the procedure document may not contain sufficient information to successfully complete the task. Therefore, the worker might have to carry additional documents such as turnover sheets, operation experience, drawings, and other procedures to the work site. The nuclear industry is operated with paper procedures like paper catalogs of the past. A field worker may carry a large stack of documents needed to complete a task to the field. Even though the paper process has helped keep the industry safe for decades, there are limitations to using paper. Paper procedures are static (i.e., the content does not change after the document is printed), difficult to search, and rely heavily on the field worker’s situational awareness and ability to consistently meet the high expectation of human performance excellence. With computer-based procedures (CBPs) that stack of papers may be reduced to the size of a small tablet or even a smart phone. Instead of manually matching equipment identification numbers listed in the procedure with the number on the physical equipment the field worker can simply scan a barcode to ensure the correct valve is opened while simultaneously creating a record. Instead of navigating through a maze of cross-references, CBPs enable intelligent work path navigation which accounts for past decisions and observation, thereby enabling more efficient and safe task completion.« less

Indicators of School Crime and Safety: 2016. NCES 2017-064/NCJ 250650

ERIC Educational Resources Information Center

Zhang, Anlan; Wang, Ke; Zhang, Jizhi; Oudekerk, Barbara A.

2017-01-01

The nation's schools should be safe havens for teaching and learning, free of crime and violence. Any instance of crime or violence at school not only affects the individuals involved, but also may disrupt the educational process and affect bystanders, the school itself, and the surrounding community. Establishing reliable indicators of the…

78 FR 22363 - Environmental Impact Statement for the All Aboard Florida Miami-Orlando Passenger Rail Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-15

... need and demand for safe, convenient, and reliable transportation through the development of a... objectives concerning the environment. AAF is a subsidiary of Florida East Coast Industries, Inc. (FECI... freight service. AAF is working to secure access to use the right-of- way of State Road 528 between Cocoa...

Quantitative Determination of Citric and Ascorbic Acid in Powdered Drink Mixes

ERIC Educational Resources Information Center

Sigmann, Samuella B.; Wheeler, Dale E.

2004-01-01

A procedure by which the reactions are used to quantitatively determine the amount of total acid, the amount of total ascorbic acid and the amount of citric acid in a given sample of powdered drink mix, are described. A safe, reliable and low-cost quantitative method to analyze consumer product for acid content is provided.

The application and technology of implantable neuromuscular stimulators: an introduction and overview.

PubMed

Jarvis, J C; Salmons, S

2001-01-01

The design of an implantable neuromuscular stimulator represents a trade-off in which the desire to maximise functionality and operational life competes with the need for the implanted device to be small, reliable, safe, and easy to use. In this introduction and overview we consider the basic problems and the different approaches to their solution.

Personnel safety with pressurized gas systems

DOE PAGES

Cadwallader, Lee C.; Zhao, Haihua

2016-09-08

In this study, selected accident case histories are described that illustrate the potential modes of injury from gas jets, pressure-driven missiles, and asphyxiants. Gas combustion hazards are also briefly mentioned. Using high-pressure helium and nitrogen, estimates of safe exclusion distances are calculated for differing pressures, temperatures, and breach sizes. Some sources for gas system reliability values are also cited.

Force feedback requirements for efficient laparoscopic grasp control.

PubMed

Westebring-van der Putten, Eleonora P; van den Dobbelsteen, John J; Goossens, Richard H M; Jakimowicz, Jack J; Dankelman, Jenny

2009-09-01

During laparoscopic grasping, tissue damage may occur due to use of excessive grasp forces and tissue slippage, whereas in barehanded grasping, humans control their grasp to prevent slippage and use of excessive force (safe grasp). This study investigates the differences in grasp control during barehanded and laparoscopic lifts. Ten novices performed lifts in order to compare pinch forces under four conditions: barehanded; using tweezers; a low-efficient grasper; and a high-efficient grasper. Results showed that participants increased their pinch force significantly later during a barehanded lift (at a pull-force level of 2.63 N) than when lifting laparoscopically (from pull-force levels of 0.77 to 1.08 N). In barehanded lifts all participants could accomplish a safe grasp, whereas in laparoscopic lifts excessive force (up to 7.9 N) and slippage (up to 38% of the trials) occurred frequently. For novices, it can be concluded that force feedback (additional to the hand-tool interface), as in skin-tissue contact, is a prerequisite to maintain a safe grasp. Much is known about grasp control during barehanded object manipulation, especially the control of pinch forces to changing loading, whereas little is known about force perception and grasp control during tool usage. This knowledge is a prerequisite for the ergonomic design of tools that are used to manipulate objects.

Minimal support technology and in situ resource utilization for risk management of planetary spaceflight missions

NASA Astrophysics Data System (ADS)

Murphy, K. L.; Rygalov, V. Ye.; Johnson, S. B.

2009-04-01

All artificial systems and components in space degrade at higher rates than on Earth, depending in part on environmental conditions, design approach, assembly technologies, and the materials used. This degradation involves not only the hardware and software systems but the humans that interact with those systems. All technological functions and systems can be expressed through functional dependence: [Function]˜[ERU]∗[RUIS]∗[ISR]/[DR];where [ERU]efficiency (rate) of environmental resource utilization[RUIS]resource utilization infrastructure[ISR]in situ resources[DR]degradation rateThe limited resources of spaceflight and open space for autonomous missions require a high reliability (maximum possible, approaching 100%) for system functioning and operation, and must minimize the rate of any system degradation. To date, only a continuous human presence with a system in the spaceflight environment can absolutely mitigate those degradations. This mitigation is based on environmental amelioration for both the technology systems, as repair of data and spare parts, and the humans, as exercise and psychological support. Such maintenance now requires huge infrastructures, including research and development complexes and management agencies, which currently cannot move beyond the Earth. When considering what is required to move manned spaceflight from near Earth stations to remote locations such as Mars, what are the minimal technologies and infrastructures necessary for autonomous restoration of a degrading system in space? In all of the known system factors of a mission to Mars that reduce the mass load, increase the reliability, and reduce the mission’s overall risk, the current common denominator is the use of undeveloped or untested technologies. None of the technologies required to significantly reduce the risk for critical systems are currently available at acceptable readiness levels. Long term interplanetary missions require that space programs produce a craft with all systems integrated so that they are of the highest reliability. Right now, with current technologies, we cannot guarantee this reliability for a crew of six for 1000 days to Mars and back. Investigation of the technologies to answer this need and a focus of resources and research on their advancement would significantly improve chances for a safe and successful mission.

A pulse-compression-ring circuit for high-efficiency electric propulsion.

PubMed

Owens, Thomas L

2008-03-01

A highly efficient, highly reliable pulsed-power system has been developed for use in high power, repetitively pulsed inductive plasma thrusters. The pulsed inductive thruster ejects plasma propellant at a high velocity using a Lorentz force developed through inductive coupling to the plasma. Having greatly increased propellant-utilization efficiency compared to chemical rockets, this type of electric propulsion system may one day propel spacecraft on long-duration deep-space missions. High system reliability and electrical efficiency are extremely important for these extended missions. In the prototype pulsed-power system described here, exceptional reliability is achieved using a pulse-compression circuit driven by both active solid-state switching and passive magnetic switching. High efficiency is achieved using a novel ring architecture that recovers unused energy in a pulse-compression system with minimal circuit loss after each impulse. As an added benefit, voltage reversal is eliminated in the ring topology, resulting in long lifetimes for energy-storage capacitors. System tests were performed using an adjustable inductive load at a voltage level of 3.3 kV, a peak current of 20 kA, and a current switching rate of 15 kA/micros.

Inter-rater reliability of an observation-based ergonomics assessment checklist for office workers.

PubMed

Pereira, Michelle Jessica; Straker, Leon Melville; Comans, Tracy Anne; Johnston, Venerina

2016-12-01

To establish the inter-rater reliability of an observation-based ergonomics assessment checklist for computer workers. A 37-item (38-item if a laptop was part of the workstation) comprehensive observational ergonomics assessment checklist comparable to government guidelines and up to date with empirical evidence was developed. Two trained practitioners assessed full-time office workers performing their usual computer-based work and evaluated the suitability of workstations used. Practitioners assessed each participant consecutively. The order of assessors was randomised, and the second assessor was blinded to the findings of the first. Unadjusted kappa coefficients between the raters were obtained for the overall checklist and subsections that were formed from question-items relevant to specific workstation equipment. Twenty-seven office workers were recruited. The inter-rater reliability between two trained practitioners achieved moderate to good reliability for all except one checklist component. This checklist has mostly moderate to good reliability between two trained practitioners. Practitioner Summary: This reliable ergonomics assessment checklist for computer workers was designed using accessible government guidelines and supplemented with up-to-date evidence. Employers in Queensland (Australia) can fulfil legislative requirements by using this reliable checklist to identify and subsequently address potential risk factors for work-related injury to provide a safe working environment.

A high voltage electrical power system for low Earth orbit applications

NASA Technical Reports Server (NTRS)

Lanier, J. R., Jr.; Bush, J. R., Jr.

1984-01-01

The results of testing a high voltage electrical power system (EPS) breadboard using high voltage power processing equipment developed at Marshall Space Flight Center and Ni-Cd batteries are discussed. These test results are used to extrapolate to an efficient, reliable, high capacity EPS for near term low Earth orbit, high power applications. EPS efficiencies, figures of merit, and battery reliability with a battery protection and reconditioning circuit are presented.

Performance and reliability enhancement of linear coolers

NASA Astrophysics Data System (ADS)

Mai, M.; Rühlich, I.; Schreiter, A.; Zehner, S.

2010-04-01

Highest efficiency states a crucial requirement for modern tactical IR cryocooling systems. For enhancement of overall efficiency, AIM cryocooler designs where reassessed considering all relevant loss mechanisms and associated components. Performed investigation was based on state-of-the-art simulation software featuring magnet circuitry analysis as well as computational fluid dynamics (CFD) to realistically replicate thermodynamic interactions. As a result, an improved design for AIM linear coolers could be derived. This paper gives an overview on performance enhancement activities and major results. An additional key-requirement for cryocoolers is reliability. In recent time, AIM has introduced linear coolers with full Flexure Bearing suspension on both ends of the driving mechanism incorporating Moving Magnet piston drive. In conjunction with a Pulse-Tube coldfinger these coolers are capable of meeting MTTF's (Mean Time To Failure) in excess of 50,000 hours offering superior reliability for space applications. Ongoing development also focuses on reliability enhancement, deriving space technology into tactical solutions combining both, excelling specific performance with space like reliability. Concerned publication will summarize the progress of this reliability program and give further prospect.

High-Performance, Reliable Multicasting: Foundations for Future Internet Groupware Applications

NASA Technical Reports Server (NTRS)

Callahan, John; Montgomery, Todd; Whetten, Brian

1997-01-01

Network protocols that provide efficient, reliable, and totally-ordered message delivery to large numbers of users will be needed to support many future Internet applications. The Reliable Multicast Protocol (RMP) is implemented on top of IP multicast to facilitate reliable transfer of data for replicated databases and groupware applications that will emerge on the Internet over the next decade. This paper explores some of the basic questions and applications of reliable multicasting in the context of the development and analysis of RMP.

General Monte Carlo reliability simulation code including common mode failures and HARP fault/error-handling

NASA Technical Reports Server (NTRS)

Platt, M. E.; Lewis, E. E.; Boehm, F.

1991-01-01

A Monte Carlo Fortran computer program was developed that uses two variance reduction techniques for computing system reliability applicable to solving very large highly reliable fault-tolerant systems. The program is consistent with the hybrid automated reliability predictor (HARP) code which employs behavioral decomposition and complex fault-error handling models. This new capability is called MC-HARP which efficiently solves reliability models with non-constant failures rates (Weibull). Common mode failure modeling is also a specialty.

The design and implementation of on-line monitoring system for UHV compact shunt capacitors

NASA Astrophysics Data System (ADS)

Tao, Weiliang; Ni, Xuefeng; Lin, Hao; Jiang, Shengbao

2017-08-01

Because of the large capacity and compact structure of the UHV compact shunt capacitor, it is difficult to take effective measures to detect and prevent the faults. If the fault capacitor fails to take timely maintenance, it will pose a threat to the safe operation of the system and the life safety of the maintenance personnel. The development of UHV compact shunt capacitor on-line monitoring system can detect and record the on-line operation information of UHV compact shunt capacitors, analyze and evaluate the early fault warning signs, find out the fault capacitor or the capacitor with fault symptom, to ensure safe and reliable operation of the system.

KSC-2009-1446

NASA Image and Video Library

2009-01-31

CAPE CANAVERAL, Fla. – The Ares I-X launch abort system that will form the tip of the Ares rocket arrives in the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The launch abort system will provide safe evacuation if a launch vehicle failure occurs. Ares I-X is the test vehicle for the Ares I, which is part of the Constellation Program to return men to the moon and beyond. Ares I is the essential core of a safe, reliable, cost-effective space transportation system that eventually will carry crewed missions back to the moon, on to Mars and out into the solar system. Ares I-X is targeted for launch in July 2009. Photo credit: NASA/Jack Pfaller

Advanced flight control system study

NASA Technical Reports Server (NTRS)

Hartmann, G. L.; Wall, J. E., Jr.; Rang, E. R.; Lee, H. P.; Schulte, R. W.; Ng, W. K.

1982-01-01

A fly by wire flight control system architecture designed for high reliability includes spare sensor and computer elements to permit safe dispatch with failed elements, thereby reducing unscheduled maintenance. A methodology capable of demonstrating that the architecture does achieve the predicted performance characteristics consists of a hierarchy of activities ranging from analytical calculations of system reliability and formal methods of software verification to iron bird testing followed by flight evaluation. Interfacing this architecture to the Lockheed S-3A aircraft for flight test is discussed. This testbed vehicle can be expanded to support flight experiments in advanced aerodynamics, electromechanical actuators, secondary power systems, flight management, new displays, and air traffic control concepts.

Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs

PubMed Central

Xia, Tian; Kovochich, Michael; Liong, Monty; Meng, Huan; Kabehie, Sanaz; Zink, Jeffrey I.; Nel, Andre E.

2014-01-01

Surface-functionalized mesoporous silica nanoparticles (MSNP) can be used as an efficient and safe carrier for bioactive molecules. In order to make the MSNP a more efficient delivery system, we modified the surface of the particles by a functional group that enhances cellular uptake and allows nucleic acid delivery in addition to traditional drug delivery. Non-covalent attachment of polyethyleneimine (PEI) polymers to the surface not only increases MSNP cellular uptake, but also generates a cationic surface to which DNA and siRNA constructs could be attached. While efficient for intracellular delivery of these nucleic acids, the 25 KD PEI polymer unfortunately changes the safety profile of the MSNP that is otherwise very safe. By experimenting with several different polymer molecular weights, it was possible to retain high cellular uptake and transfection efficiency while reducing or even eliminating cationic MSNP cytotoxicity. The particles coated with the 10 KD PEI polymer was particularly efficient for transducing HEPA-1 cells with a siRNA construct that was capable of knocking down GFP expression. Similarly, transfection of a GFP plasmid induced effective expression of the fluorescent protein in > 70% cells in the population. These outcomes were quantitatively assessed by confocal microscopy and flow cytometry. We also demonstrated that the enhanced cellular uptake of the non-toxic cationic MSNP enhance the delivery of the hydrophobic anticancer drug, paclitaxel, to pancreatic cancer cells. In summary, we demonstrate that by a careful selection of PEI size, it is possible to construct cationic MSNP that are capable of nucleotide and enhanced drug delivery with minimal or no cytotoxicity. This novel use of a cationic MSNP extends its therapeutic use potential. PMID:19739605

Efficient myogenic differentiation of human adipose-derived stem cells by the transduction of engineered MyoD protein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sung, Min Sun; Biosystems and Bioengineering Program, University of Science and Technology; Mun, Ji-Young

2013-07-19

Highlights: •MyoD was engineered to contain protein transduction domain and endosome-disruptive INF7 peptide. •The engineered MyoD-IT showed efficient nuclear targeting through an endosomal escape by INF7 peptide. •By applying MyoD-IT, human adipose-derived stem cells (hASCs) were differentiated into myogenic cells. •hASCs differentiated by applying MyoD-IT fused to myotubes through co-culturing with mouse myoblasts. •Myogenic differentiation using MyoD-IT is a safe method without the concern of altering the genome. -- Abstract: Human adipose-derived stem cells (hASCs) have great potential as cell sources for the treatment of muscle disorders. To provide a safe method for the myogenic differentiation of hASCs, we engineeredmore » the MyoD protein, a key transcription factor for myogenesis. The engineered MyoD (MyoD-IT) was designed to contain the TAT protein transduction domain for cell penetration and the membrane-disrupting INF7 peptide, which is an improved version of the HA2 peptide derived from influenza. MyoD-IT showed greatly improved nuclear targeting ability through an efficient endosomal escape induced by the pH-sensitive membrane disruption of the INF7 peptide. By applying MyoD-IT to a culture, hASCs were efficiently differentiated into long spindle-shaped myogenic cells expressing myosin heavy chains. Moreover, these cells differentiated by an application of MyoD-IT fused to myotubes with high efficiency through co-culturing with mouse C2C12 myoblasts. Because internalized proteins can be degraded in cells without altering the genome, the myogenic differentiation of hASCs using MyoD-IT would be a safe and clinically applicable method.« less

FEMA and RAM Analysis for the Multi Canister Overpack (MCO) Handling Machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

SWENSON, C.E.

2000-06-01

The Failure Modes and Effects Analysis and the Reliability, Availability, and Maintainability Analysis performed for the Multi-Canister Overpack Handling Machine (MHM) has shown that the current design provides for a safe system, but the reliability of the system (primarily due to the complexity of the interlocks and permissive controls) is relatively low. No specific failure modes were identified where significant consequences to the public occurred, or where significant impact to nearby workers should be expected. The overall reliability calculation for the MHM shows a 98.1 percent probability of operating for eight hours without failure, and an availability of the MHMmore » of 90 percent. The majority of the reliability issues are found in the interlocks and controls. The availability of appropriate spare parts and maintenance personnel, coupled with well written operating procedures, will play a more important role in successful mission completion for the MHM than other less complicated systems.« less

Reliable quantum communication over a quantum relay channel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gyongyosi, Laszlo, E-mail: gyongyosi@hit.bme.hu; Imre, Sandor

2014-12-04

We show that reliable quantum communication over an unreliable quantum relay channels is possible. The coding scheme combines the results on the superadditivity of quantum channels and the efficient quantum coding approaches.

Distributed collaborative response surface method for mechanical dynamic assembly reliability design

NASA Astrophysics Data System (ADS)

Bai, Guangchen; Fei, Chengwei

2013-11-01

Because of the randomness of many impact factors influencing the dynamic assembly relationship of complex machinery, the reliability analysis of dynamic assembly relationship needs to be accomplished considering the randomness from a probabilistic perspective. To improve the accuracy and efficiency of dynamic assembly relationship reliability analysis, the mechanical dynamic assembly reliability(MDAR) theory and a distributed collaborative response surface method(DCRSM) are proposed. The mathematic model of DCRSM is established based on the quadratic response surface function, and verified by the assembly relationship reliability analysis of aeroengine high pressure turbine(HPT) blade-tip radial running clearance(BTRRC). Through the comparison of the DCRSM, traditional response surface method(RSM) and Monte Carlo Method(MCM), the results show that the DCRSM is not able to accomplish the computational task which is impossible for the other methods when the number of simulation is more than 100 000 times, but also the computational precision for the DCRSM is basically consistent with the MCM and improved by 0.40˜4.63% to the RSM, furthermore, the computational efficiency of DCRSM is up to about 188 times of the MCM and 55 times of the RSM under 10000 times simulations. The DCRSM is demonstrated to be a feasible and effective approach for markedly improving the computational efficiency and accuracy of MDAR analysis. Thus, the proposed research provides the promising theory and method for the MDAR design and optimization, and opens a novel research direction of probabilistic analysis for developing the high-performance and high-reliability of aeroengine.

Resilience Engineering in Critical Long Term Aerospace Software Systems: A New Approach to Spacecraft Software Safety

NASA Astrophysics Data System (ADS)

Dulo, D. A.

Safety critical software systems permeate spacecraft, and in a long term venture like a starship would be pervasive in every system of the spacecraft. Yet software failure today continues to plague both the systems and the organizations that develop them resulting in the loss of life, time, money, and valuable system platforms. A starship cannot afford this type of software failure in long journeys away from home. A single software failure could have catastrophic results for the spaceship and the crew onboard. This paper will offer a new approach to developing safe reliable software systems through focusing not on the traditional safety/reliability engineering paradigms but rather by focusing on a new paradigm: Resilience and Failure Obviation Engineering. The foremost objective of this approach is the obviation of failure, coupled with the ability of a software system to prevent or adapt to complex changing conditions in real time as a safety valve should failure occur to ensure safe system continuity. Through this approach, safety is ensured through foresight to anticipate failure and to adapt to risk in real time before failure occurs. In a starship, this type of software engineering is vital. Through software developed in a resilient manner, a starship would have reduced or eliminated software failure, and would have the ability to rapidly adapt should a software system become unstable or unsafe. As a result, long term software safety, reliability, and resilience would be present for a successful long term starship mission.

SAFE KLEEN

EPA Pesticide Factsheets

Technical product bulletin: this surface washing agent used in oil spill cleanups can be applied by spray, brush, mop, or standard pressure washing equipment. Agitation during application assists efficiency.

Discover CHP

EPA Pesticide Factsheets

Access information about how CHP systems work; their efficiency, environmental, economic, and reliability benefits; the cost and performance characteristics of CHP technologies; and how to calculate CHP efficiency emissions savings.

Light Water Reactor Sustainability Program: Integrated Program Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 60%) of non-greenhouse-gas-emitting electric power generation in the United States. Domestic demand for electrical energy is expected to grow by about 24% from 2013 to 2040 . At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license, for a total of 60 years of operation (the oldest commercial plants in the Unitedmore » States reached their 40th anniversary in 2009). Figure E-1 shows projected nuclear energy contribution to the domestic generating capacity for 40- and 60-year license periods. If current operating nuclear power plants do not operate beyond 60 years (and new nuclear plants are not built quickly enough to replace them), the total fraction of generated electrical energy from nuclear power will rapidly decline. That decline will be accelerated if plants are shut down before 60 years of operation. Decisions on extended operation ultimately rely on economic factors; however, economics can often be improved through technical advancements. The U.S. Department of Energy Office of Nuclear Energy’s 2010 Research and Development Roadmap (2010 Nuclear Energy Roadmap) organizes its activities around four objectives that ensure nuclear energy remains a compelling and viable energy option for the United States. The four objectives are as follows: 1. Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors; 2. Develop improvements in the affordability of new reactors to enable nuclear energy to help meet the Administration’s energy security and climate change goals; 3. Develop sustainable nuclear fuel cycles; and 4. Understand and minimize the risks of nuclear proliferation and terrorism. The Light Water Reactor Sustainability (LWRS) Program is the primary programmatic activity that addresses Objective 1. This document summarizes the LWRS Program’s plans. For the LWRS Program, sustainability is defined as the ability to maintain safe and economic operation of the existing fleet of nuclear power plants for a longer-than-initially-licensed lifetime. It has two facets with respect to long-term operations: (1) manage the aging of plant systems, structures, and components so that nuclear power plant lifetimes can be extended and the plants can continue to operate safely, efficiently, and economically; and (2) provide science-based solutions to the industry to implement technology to exceed the performance of the current labor-intensive business model.« less

Olkiluoto 1 and 2 - Plant efficiency improvement and lifetime extension-project (PELE) implemented during outages 2010 and 2011

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kosonen, M.; Hakola, M.

2012-07-01

Teollisuuden Voima Oyj (TVO) is a non-listed public company founded in 1969 to produce electricity for its stakeholders. TVO is the operator of the Olkiluoto nuclear power plant. TVO follows the principle of continuous improvement in the operation and maintenance of the Olkiluoto plant units. The PELE project (Plant Efficiency Improvement and Lifetime Extension), mainly completed during the annual outages in 2010 and 2011, and forms one part of the systematic development of Olkiluoto units. TVO maintains a long-term development program that aims at systematically modernizing the plant unit systems and equipment based on the latest technology. According to themore » program, the Olkiluoto 1 and Olkiluoto 2 plant units are constantly renovated with the intention of keeping them safe and reliable, The aim of the modernization projects is to improve the safety, reliability, and performance of the plant units. PELE project at Olkiluoto 1 was done in 2010 and at Olkiluoto 2 in 2011. The outage length of Olkiluoto 1 was 26 d 12 h 4 min and Olkiluoto 2 outage length was 28 d 23 h 46 min. (Normal service-outage is about 14 days including refueling and refueling-outage length is about seven days. See figure 1) The PELE project consisted of several single projects collected into one for coordinated project management. Some of the main projects were as follows: - Low pressure turbines: rotor, stator vane, casing and turbine instrumentation replacement. - Replacement of Condenser Cooling Water (later called seawater pumps) pumps - Replacement of inner isolation valves on the main steam lines. - Generator and the generator cooling system replacement. - Low voltage switchgear replacement. This project will continue during future outages. PELE was a success. 100 TVO employees and 1500 subcontractor employees participated in the project. The execution of the PELE projects went extremely well during the outages. The replacement of the low pressure turbines and seawater pumps improved the efficiency of the plant units, and a power increase of nearly 20 MW was achieved at both plant units. PELE wonderfully manifests one of the strategic goals of our company; developing the competence of our in-house personnel by working in projects. (authors)« less

Building Operations Efficiencies into NASA's Ares I Crew Launch Vehicle Design

NASA Technical Reports Server (NTRS)

Dumbacher, Daniel L.; Davis, Stephan R.

2007-01-01

The U.S. Vision for Space Exploration guides the National Aeronautics and Space Administration's (NASA's) challenging missions that expand humanity's boundaries and open new routes to the space frontier. With the Agency's commitment to complete the International Space Station (ISS) and to retire the venerable Space Shuttle by 2010, the NASA Administrator commissioned the Exploration Systems Architecture Study (ESAS) in 2005 to analyze options for safe, simple, cost-efficient launch solutions that could deliver human-rated space transportation capabilities in a timely manner within fixed budget guidelines. The Exploration Launch Projects (ELP) Office, chartered by the Constellation Program in October 2005, has been conducting systems engineering studies and business planning to successively refine the design configurations and better align vehicle concepts with customer and stakeholder requirements, such as significantly reduced life-cycle costs. As the Agency begins the process of replacing the Shuttle with a new generation of spacecraft destined for missions beyond low-Earth orbit to the Moon and Mars, NASA is designing the follow-on crew and cargo launch systems for maximum operational efficiencies. To sustain the long-term exploration of space, it is imperative to reduce the $4 billion NASA typically spends on space transportation each year. This paper gives toplevel information about how the follow-on Ares I Crew Launch Vehicle (CLV) is being designed for improved safety and reliability, coupled with reduced operations costs. These methods include carefully developing operational requirements; conducting operability design and analysis; using the latest information technology tools to design and simulate the vehicle; and developing a learning culture across the workforce to ensure a smooth transition between Space Shuttle operations and Ares vehicle development.

CFD modeling to improve safe and efficient distribution of chlorine dioxide gas for packaging fresh produce

USDA-ARS?s Scientific Manuscript database

The efficiency of the packaging system in inactivating food borne pathogens and prolonging the shelf life of fresh-cut produce is influenced by the design of the package apart from material and atmospheric conditions. Three different designs were considered to determine a specific package design ens...

Probabilistic Risk Assessment (PRA): A Practical and Cost Effective Approach

NASA Technical Reports Server (NTRS)

Lee, Lydia L.; Ingegneri, Antonino J.; Djam, Melody

2006-01-01

The Lunar Reconnaissance Orbiter (LRO) is the first mission of the Robotic Lunar Exploration Program (RLEP), a space exploration venture to the Moon, Mars and beyond. The LRO mission includes spacecraft developed by NASA Goddard Space Flight Center (GSFC) and seven instruments built by GSFC, Russia, and contractors across the nation. LRO is defined as a measurement mission, not a science mission. It emphasizes the overall objectives of obtaining data to facilitate returning mankind safely to the Moon in preparation for an eventual manned mission to Mars. As the first mission in response to the President's commitment of the journey of exploring the solar system and beyond: returning to the Moon in the next decade, then venturing further into the solar system, ultimately sending humans to Mars and beyond, LRO has high-visibility to the public but limited resources and a tight schedule. This paper demonstrates how NASA's Lunar Reconnaissance Orbiter Mission project office incorporated reliability analyses in assessing risks and performing design tradeoffs to ensure mission success. Risk assessment is performed using NASA Procedural Requirements (NPR) 8705.5 - Probabilistic Risk Assessment (PRA) Procedures for NASA Programs and Projects to formulate probabilistic risk assessment (PRA). As required, a limited scope PRA is being performed for the LRO project. The PRA is used to optimize the mission design within mandated budget, manpower, and schedule constraints. The technique that LRO project office uses to perform PRA relies on the application of a component failure database to quantify the potential mission success risks. To ensure mission success in an efficient manner, low cost and tight schedule, the traditional reliability analyses, such as reliability predictions, Failure Modes and Effects Analysis (FMEA), and Fault Tree Analysis (FTA), are used to perform PRA for the large system of LRO with more than 14,000 piece parts and over 120 purchased or contractor built components.

Rapid and Efficient Filtration-Based Procedure for Separation and Safe Analysis of CBRN Mixed Samples

PubMed Central

Bentahir, Mostafa; Laduron, Frederic; Irenge, Leonid; Ambroise, Jérôme; Gala, Jean-Luc

2014-01-01

Separating CBRN mixed samples that contain both chemical and biological warfare agents (CB mixed sample) in liquid and solid matrices remains a very challenging issue. Parameters were set up to assess the performance of a simple filtration-based method first optimized on separate C- and B-agents, and then assessed on a model of CB mixed sample. In this model, MS2 bacteriophage, Autographa californica nuclear polyhedrosis baculovirus (AcNPV), Bacillus atrophaeus and Bacillus subtilis spores were used as biological agent simulants whereas ethyl methylphosphonic acid (EMPA) and pinacolyl methylphophonic acid (PMPA) were used as VX and soman (GD) nerve agent surrogates, respectively. Nanoseparation centrifugal devices with various pore size cut-off (30 kD up to 0.45 µm) and three RNA extraction methods (Invisorb, EZ1 and Nuclisens) were compared. RNA (MS2) and DNA (AcNPV) quantification was carried out by means of specific and sensitive quantitative real-time PCRs (qPCR). Liquid chromatography coupled to time-of-flight mass spectrometry (LC/TOFMS) methods was used for quantifying EMPA and PMPA. Culture methods and qPCR demonstrated that membranes with a 30 kD cut-off retain more than 99.99% of biological agents (MS2, AcNPV, Bacillus Atrophaeus and Bacillus subtilis spores) tested separately. A rapid and reliable separation of CB mixed sample models (MS2/PEG-400 and MS2/EMPA/PMPA) contained in simple liquid or complex matrices such as sand and soil was also successfully achieved on a 30 kD filter with more than 99.99% retention of MS2 on the filter membrane, and up to 99% of PEG-400, EMPA and PMPA recovery in the filtrate. The whole separation process turnaround-time (TAT) was less than 10 minutes. The filtration method appears to be rapid, versatile and extremely efficient. The separation method developed in this work constitutes therefore a useful model for further evaluating and comparing additional separation alternative procedures for a safe handling and preparation of CB mixed samples. PMID:24505375

Technology Development for Hydrogen Propellant Storage and Transfer at the Kennedy Space Center (KSC)

NASA Technical Reports Server (NTRS)

Youngquist, Robert; Starr, Stanley; Krenn, Angela; Captain, Janine; Williams, Martha

2016-01-01

The National Aeronautics and Space Administration (NASA) is a major user of liquid hydrogen. In particular, NASA's John F. Kennedy (KSC) Space Center has operated facilities for handling and storing very large quantities of liquid hydrogen (LH2) since the early 1960s. Safe operations pose unique challenges and as a result NASA has invested in technology development to improve operational efficiency and safety. This paper reviews recent innovations including methods of leak and fire detection and aspects of large storage tank health and integrity. We also discuss the use of liquid hydrogen in space and issues we are addressing to ensure safe and efficient operations should hydrogen be used as a propellant derived from in-situ volatiles.

A reagent for safe and efficient diazo-transfer to primary amines: 2-azido-1,3-dimethylimidazolinium hexafluorophosphate.

PubMed

Kitamura, Mitsuru; Kato, So; Yano, Masakazu; Tashiro, Norifumi; Shiratake, Yuichiro; Sando, Mitsuyoshi; Okauchi, Tatsuo

2014-07-07

Organic azides were prepared from primary amines in high yields by a metal free diazo-transfer reaction using 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP), which is safe and stable crystalline. The choice of base was important in the diazo-transfer reaction. In general, 4-(N,N-dimethyl)aminopyridine (DMAP) was efficient, but a stronger base such as alkylamine or DBU was more appropriate for the reaction of nucleophilic primary amines. X-ray single crystal structural analysis and geometry optimization using density functional theory (B3LYP/6-31G**) were conducted to study the ADMP structure, and the diazo-transfer reaction mechanism was explained with the help of the results of these analyses.

A particle swarm model for estimating reliability and scheduling system maintenance

NASA Astrophysics Data System (ADS)

Puzis, Rami; Shirtz, Dov; Elovici, Yuval

2016-05-01

Modifying data and information system components may introduce new errors and deteriorate the reliability of the system. Reliability can be efficiently regained with reliability centred maintenance, which requires reliability estimation for maintenance scheduling. A variant of the particle swarm model is used to estimate reliability of systems implemented according to the model view controller paradigm. Simulations based on data collected from an online system of a large financial institute are used to compare three component-level maintenance policies. Results show that appropriately scheduled component-level maintenance greatly reduces the cost of upholding an acceptable level of reliability by reducing the need in system-wide maintenance.

Two tradeoffs between economy and reliability in loss of load probability constrained unit commitment

NASA Astrophysics Data System (ADS)

Liu, Yuan; Wang, Mingqiang; Ning, Xingyao

2018-02-01

Spinning reserve (SR) should be scheduled considering the balance between economy and reliability. To address the computational intractability cursed by the computation of loss of load probability (LOLP), many probabilistic methods use simplified formulations of LOLP to improve the computational efficiency. Two tradeoffs embedded in the SR optimization model are not explicitly analyzed in these methods. In this paper, two tradeoffs including primary tradeoff and secondary tradeoff between economy and reliability in the maximum LOLP constrained unit commitment (UC) model are explored and analyzed in a small system and in IEEE-RTS System. The analysis on the two tradeoffs can help in establishing new efficient simplified LOLP formulations and new SR optimization models.

Reliability and cost-effectiveness of complete lymph node dissection under tumescent local anaesthesia vs. general anaesthesia: a retrospective analysis in patients with malignant melanoma AJCC stage III.

PubMed

Stoffels, I; Dissemond, J; Schulz, A; Hillen, U; Schadendorf, D; Klode, J

2012-02-01

Complete lymph node dissection (CLND) in melanoma patients with a positive sentinel lymph node (SLN) is currently being debated, as it is a cost-intensive surgical intervention with potentially high morbidity. This clinical study seeks to clarify the effectiveness, reliability and cost-effectiveness of CLND performed under tumescent local anaesthesia (TLA) compared with procedures under general anaesthesia (GA). We retrospectively analysed the data from 60 patients with primary malignant melanoma American Joint Committee on Cancer stage III who underwent CLND. Altogether 26 (43.3%) patients underwent CLND under TLA and 34 (56.7%) patients underwent CLND under GA. Fifteen of 43 (34.9%) patients had a complication, such as development of seromas and/or wound infections. The rate of complications was 25.0% (3/12) in the axilla subgroup and 28.6% (4/14) in the groin subgroup of the TLA group. In the GA group, the complication rate was 31.3% (5/16) in the axilla subgroup and 44.4% (8/18) in the groin subgroup. The costs for CLND were significantly less for the CLND in a procedure room performed under TLA (mean €67.26) compared with CLND in an operating room under GA (mean €676.20, P < 0.0001). In conclusion, this study confirms that TLA is an excellent, safe, effective and cost-efficient alternative to GA for CLND in melanoma patients. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

An innovative way of thinking nuclear waste management - Neutron physics of a reactor directly operating on SNF.

PubMed

Merk, Bruno; Litskevich, Dzianis; Bankhead, Mark; Taylor, Richard J

2017-01-01

A solution for the nuclear waste problem is the key challenge for an extensive use of nuclear reactors as a major carbon free, sustainable, and applied highly reliable energy source. Partitioning and Transmutation (P&T) promises a solution for improved waste management. Current strategies rely on systems designed in the 60's for the massive production of plutonium. We propose an innovative strategic development plan based on invention and innovation described with the concept of developments in s-curves identifying the current boundary conditions, and the evolvable objectives. This leads to the ultimate, universal vision for energy production characterized by minimal use of resources and production of waste, while being economically affordable and safe, secure and reliable in operation. This vision is transformed into a mission for a disruptive development of the future nuclear energy system operated by burning of existing spent nuclear fuel (SNF) without prior reprocessing. This highly innovative approach fulfils the sustainability goals and creates new options for P&T. A proof on the feasibility from neutronic point of view is given demonstrating sufficient breeding of fissile material from the inserted SNF. The system does neither require new resources nor produce additional waste, thus it provides a highly sustainable option for a future nuclear system fulfilling the requests of P&T as side effect. In addition, this nuclear system provides enhanced resistance against misuse of Pu and a significantly reduced fuel cycle. However, the new system requires a demand driven rethinking of the separation process to be efficient.

An innovative way of thinking nuclear waste management – Neutron physics of a reactor directly operating on SNF

PubMed Central

Litskevich, Dzianis; Bankhead, Mark; Taylor, Richard J.

2017-01-01

A solution for the nuclear waste problem is the key challenge for an extensive use of nuclear reactors as a major carbon free, sustainable, and applied highly reliable energy source. Partitioning and Transmutation (P&T) promises a solution for improved waste management. Current strategies rely on systems designed in the 60’s for the massive production of plutonium. We propose an innovative strategic development plan based on invention and innovation described with the concept of developments in s-curves identifying the current boundary conditions, and the evolvable objectives. This leads to the ultimate, universal vision for energy production characterized by minimal use of resources and production of waste, while being economically affordable and safe, secure and reliable in operation. This vision is transformed into a mission for a disruptive development of the future nuclear energy system operated by burning of existing spent nuclear fuel (SNF) without prior reprocessing. This highly innovative approach fulfils the sustainability goals and creates new options for P&T. A proof on the feasibility from neutronic point of view is given demonstrating sufficient breeding of fissile material from the inserted SNF. The system does neither require new resources nor produce additional waste, thus it provides a highly sustainable option for a future nuclear system fulfilling the requests of P&T as side effect. In addition, this nuclear system provides enhanced resistance against misuse of Pu and a significantly reduced fuel cycle. However, the new system requires a demand driven rethinking of the separation process to be efficient. PMID:28749952

Use of Drying Technologies for Resource Recovery from Solid Wastes and Brines

NASA Technical Reports Server (NTRS)

Wignarajah, Kanapathipillai; Alba, Ric; Fisher, John W.; Hogan, John A.; Polonsky, Alex

2010-01-01

Long term storage of unprocessed biological wastes and human wastes can present major health issues and a loss of potential resources. Space vehicles and planetary habitats are typically resource-scarce or resource-limited environments for long-term human habitation. To-date, most of the resources will need to be supplied from Earth, but this may not be possible for long duration human exploration. Based on present knowledge, there is only very limited in-situ resources on planetary habitats. Hence, the opportunity to "live off the land" in a planetary habitat is limited. However, if we assume that wastes generated by human explorers are viewed as resources, there is great potential to utilize and recycle them, thereby reducing the requirements for supply Earth and enabling the "live off the land" exploration scenario. Technologies used for the recovery of resources from wastes should be reliable, safe, easy to operate, fail-proof, modular, automated and preferably multifunctional in being capable of handling mixed solid and liquid wastes. For a lunar habitat, energy does not appear to be the major driving factor amongst the technologies studied. Instead, reliability appears to be more important[1] . This paper reports studies to date on drying technologies to remove water from solid wastes and brines. Experimental performance data obtained for recovery water from wastes and brine are presented. Simplicity of operation of hardware and energy efficiency are discussed. Some improvements and modifications to hardware were performed. Hopefully, this information will assist in future efforts in the "downselection" of technologies for recovery of water and resources from solid wastes and brines.

[CRISPR/CAS9, the King of Genome Editing Tools].

PubMed

Bannikov, A V; Lavrov, A V

2017-01-01

The discovery of CRISPR/Cas9 brought a hope for having an efficient, reliable, and readily available tool for genome editing. CRISPR/Cas9 is certainly easy to use, while its efficiency and reliability remain the focus of studies. The review describes the general principles of the organization and function of Cas nucleases and a number of important issues to be considered while planning genome editing experiments with CRISPR/Cas9. The issues include evaluation of the efficiency and specificity for Cas9, sgRNA selection, Cas9 variants designed artificially, and use of homologous recombination and nonhomologous end joining in DNA editing.

Rapidly separating microneedles for transdermal drug delivery.

PubMed

Zhu, Dan Dan; Wang, Qi Lei; Liu, Xu Bo; Guo, Xin Dong

2016-09-01

The applications of polymer microneedles (MNs) into human skin emerged as an alternative of the conventional hypodermic needles. However, dissolving MNs require many minutes to be dissolved in the skin and typically have difficulty being fully inserted into the skin, which may lead to the low drug delivery efficiency. To address these issues, we introduce rapidly separating MNs that can rapidly deliver drugs into the skin in a minimally invasive way. For the rapidly separating MNs, drug loaded dissolving MNs are mounted on the top of solid MNs, which are made of biodegradable polylactic acid which eliminate the biohazardous waste. These MNs have sufficient mechanical strength to be inserted into the skin with the drug loaded tips fully embedded for subsequent dissolution. Compared with the traditional MNs, rapidly separating MNs achieve over 90% of drug delivery efficiency in 30s while the traditional MNs needs 2min to achieve the same efficiency. With the in vivo test in mice, the micro-holes caused by rapidly separating MNs can heal in 1h, indicating that the rapidly separating MNs are safe for future applications. These results indicate that the design of rapidly separating dissolvable MNs can offer a quick, high efficient, convenient, safe and potentially self-administered method of drug delivery. Polymer microneedles offer an attractive, painless and minimally invasive approach for transdermal drug delivery. However, dissolving microneedles require many minutes to be dissolved in the skin and typically have difficulty being fully inserted into the skin due to the skin deformation, which may lead to the low drug delivery efficiency. In this work we proposed rapidly separating microneedles which can deliver over 90% of drug into the skin in 30s. The in vitro and in vivo results indicate that the new design of these microneedles can offer a quick, high efficient, convenient and safe method for transdermal drug delivery. Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Water Mediated Wittig Reactions of Aldehydes in the Teaching Laboratory: Using Sodium Bicarbonate for the in Situ Formation of Stabilized Ylides

ERIC Educational Resources Information Center

Kelly, Michael J. B.; Fallot, Lucas B.; Gustafson, Jeffrey L.; Bergdahl, B. Mikael

2016-01-01

The synthesis of alkenes using the Wittig reaction is a traditional part of many undergraduate organic chemistry teaching laboratory curricula. The aqueous medium version of the Wittig reaction presented is a reliable adaptation of this alkene formation reaction as a very safe alternative in the introductory organic chemistry laboratory. The…

A Study of Reasons for Participation in Continuing Professional Education in the U.S. Nuclear Power Industry

ERIC Educational Resources Information Center

McCamey, Randy B.

2003-01-01

The need for workers in the U.S. nuclear power industry to continually update their knowledge, skills, and abilities is critical to the safe and reliable operation of the country's nuclear power facilities. To improve their skills, knowledge, and abilities, many professionals in the nuclear power industry participate in continuing professional…

78 FR 73921 - California High-Speed Rail Authority-Construction Exemption-In Fresno, Kings, Tulare, and Kern...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

... of the Authorization & Issuance of Gen. Obligation Bonds to be Issued Pursuant to the Safe, Reliable... under the National Environmental Policy Act, 42 U.S.C. 4321 et seq. OEA is currently working with FRA.... 10502(b). This action will not significantly affect either the quality of the human environment or the...

If Nuclear Energy Is the Answer, Why Doesn't Everyone Agree?

ERIC Educational Resources Information Center

Roberts, J. W.

2018-01-01

Nuclear energy produces low carbon, safe and reliable electricity so is it now time for the UK to invest in this proven technology or are the misplaced perceptions regarding its safety, cost and the quantities of radioactive waste produced causing us to overlook nuclear as a major component of our electricity mix? This paper discusses these issues…

Microsoft, Al-Jazeera, and the Predator: The Challenge of Effects-Based Operations in the Global War on Terrorism

DTIC Science & Technology

2005-12-01

physical (e.g., safe houses and training grounds) and virtual (e.g., reliable communication and financial networks)—that terrorists need to plan... Coursebook . Maxwell AFB, AL: ACSC, 2005, 454. Tzu, Sun. “Sun Tzu on the Art of War.” Strategy and War Coursebook . Maxwell AFB, AL: ACSC, 2004

Electronic switches and control circuits: A compilation

NASA Technical Reports Server (NTRS)

1971-01-01

The innovations in this updated series of compilations dealing with electronic technology represents a carefully selected collection of items on electronic switches and control circuits. Most of the items are based on well-known circuit design concepts that have been simplified or refined to meet NASA's demanding requirement for reliability, simplicity, fail-safe characteristics, and the capability of withstanding environmental extremes.

Sociotechnical attributes of safe and unsafe work systems.

PubMed

Kleiner, Brian M; Hettinger, Lawrence J; DeJoy, David M; Huang, Yuang-Hsiang; Love, Peter E D

2015-01-01

Theoretical and practical approaches to safety based on sociotechnical systems principles place heavy emphasis on the intersections between social-organisational and technical-work process factors. Within this perspective, work system design emphasises factors such as the joint optimisation of social and technical processes, a focus on reliable human-system performance and safety metrics as design and analysis criteria, the maintenance of a realistic and consistent set of safety objectives and policies, and regular access to the expertise and input of workers. We discuss three current approaches to the analysis and design of complex sociotechnical systems: human-systems integration, macroergonomics and safety climate. Each approach emphasises key sociotechnical systems themes, and each prescribes a more holistic perspective on work systems than do traditional theories and methods. We contrast these perspectives with historical precedents such as system safety and traditional human factors and ergonomics, and describe potential future directions for their application in research and practice. The identification of factors that can reliably distinguish between safe and unsafe work systems is an important concern for ergonomists and other safety professionals. This paper presents a variety of sociotechnical systems perspectives on intersections between social--organisational and technology--work process factors as they impact work system analysis, design and operation.

Reliability analysis applied to structural tests

NASA Technical Reports Server (NTRS)

Diamond, P.; Payne, A. O.

1972-01-01

The application of reliability theory to predict, from structural fatigue test data, the risk of failure of a structure under service conditions because its load-carrying capability is progressively reduced by the extension of a fatigue crack, is considered. The procedure is applicable to both safe-life and fail-safe structures and, for a prescribed safety level, it will enable an inspection procedure to be planned or, if inspection is not feasible, it will evaluate the life to replacement. The theory has been further developed to cope with the case of structures with initial cracks, such as can occur in modern high-strength materials which are susceptible to the formation of small flaws during the production process. The method has been applied to a structure of high-strength steel and the results are compared with those obtained by the current life estimation procedures. This has shown that the conventional methods can be unconservative in certain cases, depending on the characteristics of the structure and the design operating conditions. The suitability of the probabilistic approach to the interpretation of the results from full-scale fatigue testing of aircraft structures is discussed and the assumptions involved are examined.

Ultrastrong Polyoxyzole Nanofiber Membranes for Dendrite-Proof and Heat-Resistant Battery Separators.

PubMed

Hao, Xiaoming; Zhu, Jian; Jiang, Xiong; Wu, Haitao; Qiao, Jinshuo; Sun, Wang; Wang, Zhenhua; Sun, Kening

2016-05-11

Polymeric nanomaterials emerge as key building blocks for engineering materials in a variety of applications. In particular, the high modulus polymeric nanofibers are suitable to prepare flexible yet strong membrane separators to prevent the growth and penetration of lithium dendrites for safe and reliable high energy lithium metal-based batteries. High ionic conductance, scalability, and low cost are other required attributes of the separator important for practical implementations. Available materials so far are difficult to comply with such stringent criteria. Here, we demonstrate a high-yield exfoliation of ultrastrong poly(p-phenylene benzobisoxazole) nanofibers from the Zylon microfibers. A highly scalable blade casting process is used to assemble these nanofibers into nanoporous membranes. These membranes possess ultimate strengths of 525 MPa, Young's moduli of 20 GPa, thermal stability up to 600 °C, and impressively low ionic resistance, enabling their use as dendrite-suppressing membrane separators in electrochemical cells. With such high-performance separators, reliable lithium-metal based batteries operated at 150 °C are also demonstrated. Those polyoxyzole nanofibers would enrich the existing library of strong nanomaterials and serve as a promising material for large-scale and cost-effective safe energy storage.

Use of antarctic analogs to support the space exploration initiative

NASA Technical Reports Server (NTRS)

Wharton, Robert; Roberts, Barney; Chiang, Erick; Lynch, John; Roberts, Carol; Buoni, Corinne; Andersen, Dale

1990-01-01

This report has discussed the Space Exploration Initiative (SEI) and the U.S. Antarctic Program (USAP) in the context of assessing the potential rationale and strategy for conducting a cooperative NASA/NSF (National Science Foundation) effort. Specifically, such an effort would address shared research and data on living and conducting scientific research in isolated, confined, hostile, and remote environments. A review of the respective goals and requirements of NASA and the NSF indicates that numerous opportunities exist to mutually benefit from sharing relevant technologies, data, and systems. Two major conclusions can be drawn: (1) The technologies, experience, and capabilities existing and developing in the aerospace community would enhance scientific research capabilities and the efficiency and effectiveness of operations in Antarctica. The transfer and application of critical technologies (e.g., power, waste management, life support) and collaboration on crew research needs (e.g., human behavior and medical support needs) would streamline the USAP operations and provide the scientific community with advancements in facilities and tools for Antarctic research. (2) Antarctica is the most appropriate earth analog for the environments of the the Moon and Mars. Using Antarctica in this way would contribute substantially to near- and long-term needs and plans for the SEI. Antarctica is one of the few ground-based analogs that would permit comprehensive and integrated studies of three areas deemed critical to productive and safe operations on the Moon and Mars: human health and productivity; innovative scientific research techniques; and reliable, efficient technologies and facilities.

Dynamic multiprotein assemblies shape the spatial structure of cell signaling.

PubMed

Nussinov, Ruth; Jang, Hyunbum

2014-01-01

Cell signaling underlies critical cellular decisions. Coordination, efficiency as well as fail-safe mechanisms are key elements. How the cell ensures that these hallmarks are at play are important questions. Cell signaling is often viewed as taking place through discrete and cross-talking pathways; oftentimes these are modularized to emphasize distinct functions. While simple, convenient and clear, such models largely neglect the spatial structure of cell signaling; they also convey inter-modular (or inter-protein) spatial separation that may not exist. Here our thesis is that cell signaling is shaped by a network of multiprotein assemblies. While pre-organized, the assemblies and network are loose and dynamic. They contain transiently-associated multiprotein complexes which are often mediated by scaffolding proteins. They are also typically anchored in the membrane, and their continuum may span the cell. IQGAP1 scaffolding protein which binds proteins including Raf, calmodulin, Mek, Erk, actin, and tens more, with actin shaping B-cell (and likely other) membrane-anchored nanoclusters and allosterically polymerizing in dynamic cytoskeleton formation, and Raf anchoring in the membrane along with Ras, provides a striking example. The multivalent network of dynamic proteins and lipids, with specific interactions forming and breaking, can be viewed as endowing gel-like properties. Collectively, this reasons that efficient, productive and reliable cell signaling takes place primarily through transient, preorganized and cooperative protein-protein interactions spanning the cell rather than stochastic, diffusion-controlled processes. Copyright © 2014 Elsevier Ltd. All rights reserved.

Use of antarctic analogs to support the space exploration initiative

NASA Astrophysics Data System (ADS)

Wharton, Robert; Roberts, Barney; Chiang, Erick; Lynch, John; Roberts, Carol; Buoni, Corinne; Andersen, Dale

1990-12-01

This report has discussed the Space Exploration Initiative (SEI) and the U.S. Antarctic Program (USAP) in the context of assessing the potential rationale and strategy for conducting a cooperative NASA/NSF (National Science Foundation) effort. Specifically, such an effort would address shared research and data on living and conducting scientific research in isolated, confined, hostile, and remote environments. A review of the respective goals and requirements of NASA and the NSF indicates that numerous opportunities exist to mutually benefit from sharing relevant technologies, data, and systems. Two major conclusions can be drawn: (1) The technologies, experience, and capabilities existing and developing in the aerospace community would enhance scientific research capabilities and the efficiency and effectiveness of operations in Antarctica. The transfer and application of critical technologies (e.g., power, waste management, life support) and collaboration on crew research needs (e.g., human behavior and medical support needs) would streamline the USAP operations and provide the scientific community with advancements in facilities and tools for Antarctic research. (2) Antarctica is the most appropriate earth analog for the environments of the the Moon and Mars. Using Antarctica in this way would contribute substantially to near- and long-term needs and plans for the SEI. Antarctica is one of the few ground-based analogs that would permit comprehensive and integrated studies of three areas deemed critical to productive and safe operations on the Moon and Mars: human health and productivity; innovative scientific research techniques; and reliable, efficient technologies and facilities.

A Cooperative Communication System for the Advancement of Safe, Effective, and Efficient Patient Care

DTIC Science & Technology

2017-02-01

for the ever-changing environment of work that must be successfully navigated. The Cooperative Communication System (CCS) is a Health Information...presented a comprehensive picture of the BICU cognitive work , including synchronization on the BICU, the barriers to safe and effective care that...room spared the need to orient participants to an unfamiliar work setting and made it possible to include environmental factors and cues that a

Cooperation and dialogical modeling for designing a safe Human space exploration mission to Mars

NASA Astrophysics Data System (ADS)

Grès, Stéphane; Tognini, Michel; Le Cardinal, Gilles; Zalila, Zyed; Gueydan, Guillaume

2014-11-01

This paper proposes an approach for a complex and innovative project requiring international contributions from different communities of knowledge and expertise. Designing a safe and reliable architecture for a manned mission to Mars or the Asteroids necessitates strong cooperation during the early stages of design to prevent and reduce risks for the astronauts at each step of the mission. The stake during design is to deal with the contradictions, antagonisms and paradoxes of the involved partners for the definition and modeling of a shared project of reference. As we see in our research which analyses the cognitive and social aspects of technological risks in major accidents, in such a project, the complexity of the global organization (during design and use) and the integration of a wide and varie d range of sciences and innovative technologies is likely to increase systemic risks as follows: human and cultural mistakes, potential defaults, failures and accidents. We identify as the main danger antiquated centralized models of organization and the operational limits of interdisciplinarity in the sciences. Beyond this, we can see that we need to take carefully into account human cooperation and the quality of relations between heterogeneous partners. Designing an open, self-learning and reliable exploration system able to self-adapt in dangerous and unforeseen situations implies a collective networked intelligence led by a safe process that organizes interaction between the actors and the aims of the project. Our work, supported by the CNES (French Space Agency), proposes an innovative approach to the coordination of a complex project.

Advanced CHP Control Algorithms: Scope Specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katipamula, Srinivas; Brambley, Michael R.

2006-04-28

The primary objective of this multiyear project is to develop algorithms for combined heat and power systems to ensure optimal performance, increase reliability, and lead to the goal of clean, efficient, reliable and affordable next generation energy systems.

WEAMR — A Weighted Energy Aware Multipath Reliable Routing Mechanism for Hotline-Based WSNs

PubMed Central

Tufail, Ali; Qamar, Arslan; Khan, Adil Mehmood; Baig, Waleed Akram; Kim, Ki-Hyung

2013-01-01

Reliable source to sink communication is the most important factor for an efficient routing protocol especially in domains of military, healthcare and disaster recovery applications. We present weighted energy aware multipath reliable routing (WEAMR), a novel energy aware multipath routing protocol which utilizes hotline-assisted routing to meet such requirements for mission critical applications. The protocol reduces the number of average hops from source to destination and provides unmatched reliability as compared to well known reactive ad hoc protocols i.e., AODV and AOMDV. Our protocol makes efficient use of network paths based on weighted cost calculation and intelligently selects the best possible paths for data transmissions. The path cost calculation considers end to end number of hops, latency and minimum energy node value in the path. In case of path failure path recalculation is done efficiently with minimum latency and control packets overhead. Our evaluation shows that our proposal provides better end-to-end delivery with less routing overhead and higher packet delivery success ratio compared to AODV and AOMDV. The use of multipath also increases overall life time of WSN network using optimum energy available paths between sender and receiver in WDNs. PMID:23669714

WEAMR-a weighted energy aware multipath reliable routing mechanism for hotline-based WSNs.

PubMed

Tufail, Ali; Qamar, Arslan; Khan, Adil Mehmood; Baig, Waleed Akram; Kim, Ki-Hyung

2013-05-13

Reliable source to sink communication is the most important factor for an efficient routing protocol especially in domains of military, healthcare and disaster recovery applications. We present weighted energy aware multipath reliable routing (WEAMR), a novel energy aware multipath routing protocol which utilizes hotline-assisted routing to meet such requirements for mission critical applications. The protocol reduces the number of average hops from source to destination and provides unmatched reliability as compared to well known reactive ad hoc protocols i.e., AODV and AOMDV. Our protocol makes efficient use of network paths based on weighted cost calculation and intelligently selects the best possible paths for data transmissions. The path cost calculation considers end to end number of hops, latency and minimum energy node value in the path. In case of path failure path recalculation is done efficiently with minimum latency and control packets overhead. Our evaluation shows that our proposal provides better end-to-end delivery with less routing overhead and higher packet delivery success ratio compared to AODV and AOMDV. The use of multipath also increases overall life time of WSN network using optimum energy available paths between sender and receiver in WDNs.

Reliability and Heat Transfer Performance of a Miniature High-Temperature Thermosyphon-Based Thermal Valve

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alleman, Jeffrey L; Olsen, Michele L; Glatzmaier, Gregory C

Latent heat thermal energy storage systems have the advantages of near isothermal heat release and high energy density compared to sensible heat, generally resulting in higher power block efficiencies. Until now, there has been no highly effective and reliable method to passively extract that stored latent energy. Most modern attempts rely on external power supplied to a pump to move viscous heat transfer fluids from the phase change material (PCM) to the power block. In this work, the problem of latent heat dispatchability has been addressed with a redesigned thermosyphon geometry that can act as a 'thermal valve' capable ofmore » passively and efficiently controlling the release of heat from a thermal reservoir. A bench-scale prototype with a stainless steel casing and sodium working fluid was designed and tested to be reliable for more than fifty 'on/off' cycles at an operating temperature of 600 degrees C. The measured thermal resistances in the 'on' and 'off' states were 0.0395 K/W and 11.0 K/W respectively. This device demonstrated efficient, fast, reliable, and passive heat extraction from a PCM and may have application to other fields and industries using thermal processing.« less