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Sample records for saha editor jonathan

  1. An Interview with Jonathan Piel.

    ERIC Educational Resources Information Center

    Graves, Diane J.

    1992-01-01

    This transcript of an interview with Jonathan Piel, editor of "Scientific American," discusses communication between scientists and readers; scientific research publications and the publishing industry; universities as research publishers; library budget reductions and purchasing decisions; electronic publishing; NREN (National Research…

  2. An Interview with Jonathan Piel.

    ERIC Educational Resources Information Center

    Graves, Diane J.

    1992-01-01

    This transcript of an interview with Jonathan Piel, editor of "Scientific American," discusses communication between scientists and readers; scientific research publications and the publishing industry; universities as research publishers; library budget reductions and purchasing decisions; electronic publishing; NREN (National Research…

  3. Jonathan Hodgkin.

    PubMed

    Hodgkin, Jonathan

    2004-04-06

    Jonathan Hodgkin graduated from Oxford in 1971 and then did a PhD with Sydney Brenner at MRC LMB in Cambridge, studying behavioural genetics in the nematode Caenorhabditis elegans. Later, after a couple of years working with myxobacteria as a postdoc in Dale Kaiser's lab at Stanford, he returned to LMB as a staff member, where he remained for most of the subsequent two decades. In the year 2000, he moved to Oxford as Professor of Genetics in the Department of Biochemistry, switching his major research interests from developmental genetics and sex determination to the study of host-pathogen interactions in the worm. For the past ten years, he has acted as curator of the C. elegans genetic map and gene nomenclature, and he is currently President of the Genetics Society of Great Britain.

  4. The SAHA syndrome.

    PubMed

    Orfanos, C E; Adler, Y D; Zouboulis, C C

    2000-01-01

    The presence of seborrhoea, acne, hirsutism and alopecia in women has first been summarized as SAHA syndrome in 1982 and can be associated with polycystic ovary syndrome, cystic mastitis, obesity and infertility. In 1994, the association of these androgen-dependent cutaneous signs, was classified according to their etiology into four types: (1) idiopathic, (2) ovarian, (3) adrenal, and (4) hyperprolactinemic SAHA. The HAIRAN syndrome has been currently described as a fifth variant with polyendocrinopathy. The SAHA syndrome generally occurs in young to middle-aged women and involves either the presence of elevated blood levels of androgens or increased androgen-driven peripheral response with normal circulating androgen levels. Peripheral metabolism of androgens takes place in various areas within the pilosebaceous unit, as indicated by local differences in the activities of aromatase, 5alpha-reductase as well as of the presence of the androgen receptors. In cases of SAHA syndrome, careful diagnostic and clinical evaluation has to be performed in order to identify the cause for peripheral hyperandrogenism and to exclude androgen-producing tumors. Treatment will target the etiology, whereas the management in idiopathic cases will aim to improve the clinical features of SAHA.

  5. The Floor of Saha E

    NASA Image and Video Library

    2009-10-27

    Diverse textures on the floor of Saha E which could be the result of impact melt coating boulders and other deposits on the floor of the crater on the lunar farside in this image taken by NASA Lunar Reconnaissance Orbiter.

  6. New Editors for AGU Journals

    NASA Astrophysics Data System (ADS)

    Panning, Jeanette

    2014-10-01

    John Orcutt, the editor in chief of Earth and Space Science, has filled in his editorial board with Andrea Donnellan (University of Southern California), Jonathan H. Jiang (NASA Jet Propulsion Laboratory, California Institute of Technology), Benoît Pirenne (University of Victoria, BC, Canada), and Frank Vernon (University of California, San Diego).

  7. Reflections on Jonathan Boston's Paper

    ERIC Educational Resources Information Center

    Devine, Nesta

    2014-01-01

    In this article, Nesta Devine responds to Jonathan Boston's article "Child Poverty in New Zealand: Why It Matters and How It Can Be Reduced" ("Educational Philosophy and Theory," v46 n9 p995-999, 2014). Devine wishes to consider Boston's position from two angles: one is to rehearse the point that these statistics are an…

  8. Reflections on Jonathan Boston's Paper

    ERIC Educational Resources Information Center

    Devine, Nesta

    2014-01-01

    In this article, Nesta Devine responds to Jonathan Boston's article "Child Poverty in New Zealand: Why It Matters and How It Can Be Reduced" ("Educational Philosophy and Theory," v46 n9 p995-999, 2014). Devine wishes to consider Boston's position from two angles: one is to rehearse the point that these statistics are an…

  9. Jonathan Taft: dentistry's great forgotten hero.

    PubMed

    Ring, Malvin E

    2006-01-01

    One of the greatest figures in the development of the dental profession to the high status it enjoys today is all but forgotten. Jonathan Taft was dean of the second dental school in the world and wrote the most important clinical textbook of his time, one that was reprinted in many editions over a quarter of a century. Later appointed dean of the new University of Michigan Dental School, he instituted innovations in admission requirements and course of study that were copied by all subsequent schools and are the standards adhered to today. The editor of one of the most important dental journals for 44 years, a record unmatched to this day, he set the standards for modern dental periodical literature that have done so much to elevate dentistry that today it stands on a par with medicine as a truly science-based profession. He served dentistry in many capacities: president of the American Dental Association, founder of the National Association of Dental Faculties, and founder of the National Association of Dental Examiners. Over his lifetime, he published almost 200 professional papers and probably attended and lectured at more dental meetings than anyone of his day and since. His memory should be resurrected, and the profession must be made aware of the great debt it owes to this intrepid fighter for a better dental profession.

  10. SAHA Suppresses Peritoneal Fibrosis in Mice

    PubMed Central

    Io, Kumiko; Nishino, Tomoya; Obata, Yoko; Kitamura, Mineaki; Koji, Takehiko; Kohno, Shigeru

    2015-01-01

    ♦ Objective: Long-term peritoneal dialysis causes peritoneal fibrosis in submesothelial areas. However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences. Among epigenetic modifications, histone acetylation leads to the transcriptional activation of genes. Recent studies indicate that histone acetylation is involved in the progression of fibrosis. Therefore, we examined the effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on the progression of peritoneal fibrosis in mice. ♦ Methods: Peritoneal fibrosis was induced by the injection of chlorhexidine gluconate (CG) into the peritoneal cavity of mice every other day for 3 weeks. SAHA, or a dimethylsulfoxide and saline vehicle, was administered subcutaneously every day from the start of the CG injections for 3 weeks. Morphologic peritoneal changes were assessed by Masson’s trichrome staining, and fibrosis-associated factors were assessed by immunohistochemistry. ♦ Results: In CG-injected mice, a marked thickening of the submesothelial compact zone was observed. In contrast, the administration of SAHA suppressed the progression of submesothelial thickening and type III collagen accumulation in CG-injected mice. The numbers of fibroblast-specific protein-1-positive cells and α-smooth muscle actin α-positive cells were significantly decreased in the CG + SAHA group compared to that of the CG group. The level of histone acetylation was reduced in the peritoneum of the CG group, whereas it was increased in the CG + SAHA group. ♦ Conclusions: Our results indicate that SAHA can suppress peritoneal thickening and fibrosis in mice through up-regulation of histone acetylation. These results suggest that SAHA may have therapeutic potential for treating peritoneal fibrosis. PMID:24584598

  11. SAHA Suppresses Peritoneal Fibrosis in Mice.

    PubMed

    Io, Kumiko; Nishino, Tomoya; Obata, Yoko; Kitamura, Mineaki; Koji, Takehiko; Kohno, Shigeru

    2015-01-01

    Long-term peritoneal dialysis causes peritoneal fibrosis in submesothelial areas. However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences. Among epigenetic modifications, histone acetylation leads to the transcriptional activation of genes. Recent studies indicate that histone acetylation is involved in the progression of fibrosis. Therefore, we examined the effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on the progression of peritoneal fibrosis in mice. Peritoneal fibrosis was induced by the injection of chlorhexidine gluconate (CG) into the peritoneal cavity of mice every other day for 3 weeks. SAHA, or a dimethylsulfoxide and saline vehicle, was administered subcutaneously every day from the start of the CG injections for 3 weeks. Morphologic peritoneal changes were assessed by Masson's trichrome staining, and fibrosis-associated factors were assessed by immunohistochemistry. In CG-injected mice, a marked thickening of the submesothelial compact zone was observed. In contrast, the administration of SAHA suppressed the progression of submesothelial thickening and type III collagen accumulation in CG-injected mice. The numbers of fibroblast-specific protein-1-positive cells and α-smooth muscle actin α-positive cells were significantly decreased in the CG + SAHA group compared to that of the CG group. The level of histone acetylation was reduced in the peritoneum of the CG group, whereas it was increased in the CG + SAHA group. Our results indicate that SAHA can suppress peritoneal thickening and fibrosis in mice through up-regulation of histone acetylation. These results suggest that SAHA may have therapeutic potential for treating peritoneal fibrosis. Copyright © 2015 International Society for Peritoneal Dialysis.

  12. Letter to the editor concerning: "a comprehensive review of thoracic deformity parameters in scoliosis" by Jonathan A. Harris, Oscar H. Mayer, Suken A. Shah, Robert M. Campbell Jr., Sriram Balasubramanian. Eur Spine J (2014) 23:2594-2602, DOI 10.1007/s00586-014-3580-8.

    PubMed

    Grivas, Theodoros B

    2015-03-01

    In this letter to the Editor, an additional radiological thoracic deformity parameter is described, which was not included in the review, namely the rib index (RI). The index and its usefulness of its application are described, both in the clinical praxis and in the aetiology of idiopathic scoliosis. The pertinent literature is also sited.

  13. New Editor

    NASA Astrophysics Data System (ADS)

    2007-03-01

    It is an honour and a challenge to take up the editorship of the Messenger at this time of ESO's expanding role in European and worldwide astronomy. In order to mark the change, we have made a few adjustments to the appearance without departing from the overall style that Peter Shaver had evolved during his term as editor. I would like to thank Peter for gen-tly coaching me into the position and Jutta Boxheimer, the technical editor, for the high quality of the layout.

  14. Editor's note

    NASA Astrophysics Data System (ADS)

    Umapathy, Siva

    2017-01-01

    This is an editor's note related to the publication 'Biologically active and thermally stable polymeric Schiff base and its metal polychelates: Their synthesis and spectral aspects' by Raza Rasool and Sumaiya Hasnain, which appeared in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 148 (2015) 435-443.

  15. Digital Learning Network Event with Robotics Engineer Jonathan Rogers

    NASA Image and Video Library

    Robotics engineer Jonathan Rogers and Public Affairs Officer Kylie Clem participate in a Digital Learning Network educational event, answering questions from students at Montgomery Middle School in...

  16. TOAD Editor

    NASA Technical Reports Server (NTRS)

    Bingle, Bradford D.; Shea, Anne L.; Hofler, Alicia S.

    1993-01-01

    Transferable Output ASCII Data (TOAD) computer program (LAR-13755), implements format designed to facilitate transfer of data across communication networks and dissimilar host computer systems. Any data file conforming to TOAD format standard called TOAD file. TOAD Editor is interactive software tool for manipulating contents of TOAD files. Commonly used to extract filtered subsets of data for visualization of results of computation. Also offers such user-oriented features as on-line help, clear English error messages, startup file, macroinstructions defined by user, command history, user variables, UNDO features, and full complement of mathematical statistical, and conversion functions. Companion program, TOAD Gateway (LAR-14484), converts data files from variety of other file formats to that of TOAD. TOAD Editor written in FORTRAN 77.

  17. WRR editors

    NASA Astrophysics Data System (ADS)

    New editors of AGU's Water Resources Research journal will be Soroosh Sorooshian and Roger E. Smith.Soroosh Sorooshian was born in Kerman, Iran. He received his B.S. degree in mechanical engineering from California State Polytechnic University, San Luis Obispo, in 1971. He received his M.S. degree in operations research in 1973 and his Ph.D. degree in water resources systems engineering in 1978, both from the University of California, Los Angeles.

  18. MPS Editor

    NASA Technical Reports Server (NTRS)

    Mathews, William S.; Liu, Ning; Francis, Laurie K.; OReilly, Taifun L.; Schrock, Mitchell; Page, Dennis N.; Morris, John R.; Joswig, Joseph C.; Crockett, Thomas M.; Shams, Khawaja S.

    2011-01-01

    Previously, it was time-consuming to hand-edit data and then set up simulation runs to find the effect and impact of the input data on a spacecraft. MPS Editor provides the user the capability to create/edit/update models and sequences, and immediately try them out using what appears to the user as one piece of software. MPS Editor provides an integrated sequencing environment for users. It provides them with software that can be utilized during development as well as actual operations. In addition, it provides them with a single, consistent, user friendly interface. MPS Editor uses the Eclipse Rich Client Platform to provide an environment that can be tailored to specific missions. It provides the capability to create and edit, and includes an Activity Dictionary to build the simulation spacecraft models, build and edit sequences of commands, and model the effects of those commands on the spacecraft. MPS Editor is written in Java using the Eclipse Rich Client Platform. It is currently built with four perspectives: the Activity Dictionary Perspective, the Project Adaptation Perspective, the Sequence Building Perspective, and the Sequence Modeling Perspective. Each perspective performs a given task. If a mission doesn't require that task, the unneeded perspective is not added to that project's delivery. In the Activity Dictionary Perspective, the user builds the project-specific activities, observations, calibrations, etc. Typically, this is used during the development phases of the mission, although it can be used later to make changes and updates to the Project Activity Dictionary. In the Adaptation Perspective, the user creates the spacecraft models such as power, data store, etc. Again, this is typically used during development, but will be used to update or add models of the spacecraft. The Sequence Building Perspective allows the user to create a sequence of activities or commands that go to the spacecraft. It provides a simulation of the activities and

  19. [Silence potentiates chemosensitivity of K562 cells to SAHA].

    PubMed

    Wang, Hou-Cai; Chen, Jing; An, Na; Yu, Teng-Teng; Li, Shou-Yun; Liu, Shuang; Wei, Hui; Rao, Qing; Wang, Min; Wang, Jian-Xiang

    2014-08-01

    Ribosomal protein S27a (RPS27a) can perform extra-ribosomal functions besides imparting a role in ribosome biogenesis and post-translational modifications of proteins. The RPS27a gene has been reported to be over-expressed in breast fibroadenomas, colorectal and renal cancers, advanced-phase chronic myeloid leukemia (CML) and acute leukemia (AL) patients. This study was purposed to explore the function of RPS27a in CML-erythroleukemia cell line K562 cells. RPS27a was silenced by short hairpin RNA (shRNA) in K562 cells. Furthermore, the proliferation changes of K562 cells was detected by MTT method after silencing the RPS27a with suberoylanilide hydroxamic acid (SAHA), then the IC50 of K562-sh1/sh2 and K562-scr cells to SAHA was measured. The results indicated that compared with K562-scr cells, the IC50 of K562-sh1/sh2 to SAHA at 24 h and 48 h decreased (P < 0.01); RPS27a silence significantly increased the percentage of apoptotic K562-sh1/sh2 cells after incubation with 1 µmol/L, 2 µmol/L and 5 µmol/L SAHA for 24 h and 48 h as compared with that of K562-scr cells (P < 0.01). K562-sh1, K562-sh2 and K562-scr cells after incubation with or without 2 µmol/L SAHA for 48 h presented apoptosis features: i. e. chromatin condensation, nucleic fragmentation and apoptotic body formation. It is concluded that RPS27a can inhibit the apoptosis of K562 cells and RPS27a silence can potentiate sensitivity of K562 cells to SAHA.

  20. Journal Editors Celebrated at Editors' Evening

    NASA Astrophysics Data System (ADS)

    Panning, Jeanette

    2014-02-01

    At the Fall Meeting, the premiere social event for AGU's many journal editors is the annual Editors' Evening, an opportunity for members to celebrate and to recognize the efforts of retiring editors. At the event, AGU president Carol Finn welcomed all those in attendance and thanked them for volunteering their time for the benefit of AGU and the wider research community.

  1. Phosphorus-based SAHA analogues as histone deacetylase inhibitors.

    PubMed

    Kapustin, Galina V; Fejér, György; Gronlund, Jennifer L; McCafferty, Dewey G; Seto, Edward; Etzkorn, Felicia A

    2003-08-21

    [structure: see text] Three analogues of suberoyl anilide hydroxamic acid (SAHA) with phosphorus metal-chelating functionalities were synthesized as inhibitors of histone deacetylases (HDACs). The compounds showed weak activity for HeLa nuclear extracts (IC(50) = 0.57-6.1 mM), HDAC8 (IC(50) = 0.28-0.41 mM), and histone-deacetylase-like protein (HDLP, IC(50) = 0.33-1.9 mM), suggesting that the transition state of HDAC is not analogous to zinc proteases. Antiproliferative activity against A2780 cancer cells (IC(50) = 0.11-0.12 mM), comparable to SAHA (0.15 mM), was observed.

  2. The Ties that Bind: A Response to Jonathan Jansen

    ERIC Educational Resources Information Center

    Sehoole, Chika Trevor

    2006-01-01

    In his critique of academic writing about and public consumption of government policy and law, Jonathan Jansen uses his argument of the symbolic functions of education law and education policy as a basis for explaining the lack of progress in achieving equity and justice under "Brown v. Board of Education" (1954) in the United States and…

  3. Savage Exaggerations: Worshiping the Cosmology of Jonathan Kozol

    ERIC Educational Resources Information Center

    Winters, Marcus A.

    2006-01-01

    Jonathan Kozol has made a good living talking with students. His books chronicle travels among poor, minority children, most of them African Americans in struggling public schools. In the four decades that Kozol, now 70, has been writing books--11 so far--his message has hardly wavered: minority children are unsuccessful because rich, white…

  4. The Ties that Bind: A Response to Jonathan Jansen

    ERIC Educational Resources Information Center

    Sehoole, Chika Trevor

    2006-01-01

    In his critique of academic writing about and public consumption of government policy and law, Jonathan Jansen uses his argument of the symbolic functions of education law and education policy as a basis for explaining the lack of progress in achieving equity and justice under "Brown v. Board of Education" (1954) in the United States and…

  5. Attacking Apartheid Education: An interview with Jonathan Kozol

    ERIC Educational Resources Information Center

    Curriculum Review, 2005

    2005-01-01

    This article presents an interview with Jonathan Kozol. Topics discussed include: (1) On the root causes of school resegregation; (2) On strategies for solving the problem; (3) On guaranteeing education for all; (4) On forcing opponents of integration into the open; (5) On mechanisms for promoting integration; (6) On scripted curricula in…

  6. Savage Exaggerations: Worshiping the Cosmology of Jonathan Kozol

    ERIC Educational Resources Information Center

    Winters, Marcus A.

    2006-01-01

    Jonathan Kozol has made a good living talking with students. His books chronicle travels among poor, minority children, most of them African Americans in struggling public schools. In the four decades that Kozol, now 70, has been writing books--11 so far--his message has hardly wavered: minority children are unsuccessful because rich, white…

  7. Dose-Responsive Gene Expression in Suberoylanilide Hydroxamic Acid (SAHA) Treated Resting CD4+ T Cells

    PubMed Central

    Reardon, Brian; Beliakova-Bethell, Nadejda; Spina, Celsa A.; Singhania, Akul; Margolis, David M.; Richman, Douglas R.; Woelk, Christopher H.

    2015-01-01

    Design Persistent latently infected CD4+ T cells represent a major obstacle to HIV eradication. Histone deacetylase inhibitors (HDACis) are a proposed activation therapy. However, off-target effects on expression in host immune cells are poorly understood. We hypothesized that HDACi-modulated genes would be best identified with dose-response analysis. Methods Resting primary CD4+ T cells were treated with 0.34, 1, 3, or 10 μM of the HDACi, SAHA, for 24 hours and subjected to microarray gene expression analysis. Genes with dose-correlated expression were filtered to identify a subset with consistent up or downregulation at each SAHA dose. Histone modifications were characterized in 6 SAHA dose-responsive genes by chromatin immunoprecipitation (ChIP-RT-qPCR). Results A large number of genes were shown to be up (N=657) or downregulated (N=725) by SAHA in a dose-responsive manner (FDR p-value < 0.05, fold change ≥ |2|). Several genes (CTNNAL1, DPEP2, H1F0, IRGM, PHF15, and SELL) are potential in vivo biomarkers of SAHA activity. SAHA dose-responsive genes included transcription factors, HIV restriction factors, histone methyltransferases, and host proteins that interact with HIV. Pathway analysis suggested net downregulation of T cell activation with increasing SAHA dose. Histone acetylation was not correlated with host gene expression, but plausible alternative mechanisms for SAHA-modulated gene expression were identified. Conclusions Numerous genes in CD4+ T cells are modulated by SAHA in a dose-responsive manner, including genes that may negatively influence HIV activation from latency. Our study suggests that SAHA influences gene expression through a confluence of several mechanisms, including histone modification, and altered expression and activity of transcription factors. PMID:26258524

  8. DNAAlignEditor: DNA alignment editor tool

    PubMed Central

    Sanchez-Villeda, Hector; Schroeder, Steven; Flint-Garcia, Sherry; Guill, Katherine E; Yamasaki, Masanori; McMullen, Michael D

    2008-01-01

    Background With advances in DNA re-sequencing methods and Next-Generation parallel sequencing approaches, there has been a large increase in genomic efforts to define and analyze the sequence variability present among individuals within a species. For very polymorphic species such as maize, this has lead to a need for intuitive, user-friendly software that aids the biologist, often with naïve programming capability, in tracking, editing, displaying, and exporting multiple individual sequence alignments. To fill this need we have developed a novel DNA alignment editor. Results We have generated a nucleotide sequence alignment editor (DNAAlignEditor) that provides an intuitive, user-friendly interface for manual editing of multiple sequence alignments with functions for input, editing, and output of sequence alignments. The color-coding of nucleotide identity and the display of associated quality score aids in the manual alignment editing process. DNAAlignEditor works as a client/server tool having two main components: a relational database that collects the processed alignments and a user interface connected to database through universal data access connectivity drivers. DNAAlignEditor can be used either as a stand-alone application or as a network application with multiple users concurrently connected. Conclusion We anticipate that this software will be of general interest to biologists and population genetics in editing DNA sequence alignments and analyzing natural sequence variation regardless of species, and will be particularly useful for manual alignment editing of sequences in species with high levels of polymorphism. PMID:18366684

  9. Boerhaave: Author and Editor *

    PubMed Central

    Lindeboom, G. A.

    1974-01-01

    The many facets of Herman Boerhaave's life are presented. He was a renowned teacher, physician, author, and editor. Discussed here are his activities as cataloger of the Vossius Collection, author of books on chemistry, botany, and medicine, and as editor of works by Vesalius and early Greek medical writers. Printing and bookselling in Leiden during Boerhaave's era are described. Images PMID:4596962

  10. Structural Requirements of HDAC Inhibitors: SAHA Analogs Functionalized Adjacent to the Hydroxamic Acid

    PubMed Central

    Bieliauskas, Anton V.; Weerasinghe, Sujith V. W.; Pflum, Mary Kay H.

    2007-01-01

    Inhibitors of histone deacetylase (HDAC) proteins such as suberoylanilide hydroxamic acid (SAHA) have emerged as effective therapeutic anti-cancer agents. To better understand the structural requirements of HDAC inhibitors, a small molecule library with a variety of substituents attached adjacent to the metal binding hydroxamic acid of SAHA was synthesized. The presence of a substituent adjacent to the hydroxamic acid led to an 800 to 5000-fold decrease in inhibition compared to SAHA. The observed results have implications for drug design, suggesting that HDAC inhibitors with substituents near the metal binding moiety will have inhibitory activities in the μM rather than nM range. PMID:17307359

  11. Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics

    NASA Astrophysics Data System (ADS)

    Mukherjee, P.

    2001-07-01

    Experimental studies of nuclear excitations have been an important subject from the earliest days when the institute was established. The construction of 4 MeV proton cyclotron was mainly aimed to achieve this goal. Early experiments in nuclear spectroscopy were done with radioactive nuclei with the help of beta and gamma ray spectrometers. Small NaI(Tl) detectors were used for gamma--gamma coincidence, angular correlation and life time measurements. The excited states nuclear magnetic moments were measured in perturbed gamma--gamma angular correlation experiments. A high transmission magnetic beta ray spectrometer was used to measure internal conversion coefficients and beta--gamma coincidence studies. A large number of significant contributions were made during 1950--59 using these facilities. Proton beam in the cyclotron was made available in the late 1950's and together with 14 MeV neutrons obtained from a C-W generator a large number of short-lived nuclei were investigated during 1960's and 1970's. The introduction of high resolution Ge gamma detectors and the improved electronics helped to extend the spectroscopic work which include on-line (p,p'g) and (p,n g) reaction studies. Nuclear spectroscopic studies entered a new phase in the 1980's with the availability of 40--80 MeV alpha beam from the variable energy cyclotron at VECC, Calcutta. A number of experimental groups were formed in the institute to study nuclear level schemes with (a,xn g) reactions. Initially only two unsuppressed Ge detectors were used for coincidence studies. Later in 1989 five Ge detectors with a large six segmented NaI(Tl) multiplicity-sum detector system were successfully used to select various channels in (a ,xn g) reactions. From 1990 to date a variety of medium energy heavy ions were made available from the BARC-TIFR Pelletron and the Nuclear Science Centre Pelletron. The state of the art gamma detector arrays in these centres enabled the Saha Institute groups to undertake more

  12. Editors' Fall Picks

    ERIC Educational Resources Information Center

    Hoffert, Barbara; Heilbrun, Margaret; Kuzyk, Raya; Kim, Ann; McCormack, Heather; Katterjohn, Anna; Burns, Ann; Williams, Wilda

    2008-01-01

    From the fall's cascade of great new books, "Library Journal's" editors select their favorites--a dark rendition of Afghan life, a look at the "self-esteem trap," a celebration of Brooklyn activism, and much more.

  13. Histone Deacetylase Inhibitor SAHA as Potential Targeted Therapy Agent for Larynx Cancer Cells.

    PubMed

    Grabarska, Aneta; Łuszczki, Jarogniew J; Nowosadzka, Ewa; Gumbarewicz, Ewelina; Jeleniewicz, Witold; Dmoszyńska-Graniczka, Magdalena; Kowalczuk, Krystyna; Kupisz, Krzysztof; Polberg, Krzysztof; Stepulak, Andrzej

    2017-01-01

    Objective: Laryngeal squamous cell carcinoma is one of the most common malignant tumors in the head and neck region. Due to the poor response to chemotherapeutics in patients and low survival rate, successful treatment of larynx cancer still remains a challenge. Therefore, the identification of novel treatment options is needed. We investigated the anticancer effects of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on two different laryngeal cancer cell lines RK33 and RK45. We also studied the antiproliferative action of SAHA in combination with cisplatin and defined the type of pharmacological interaction between these drugs. Materials and Methods: Viability and proliferation of larynx cancer cell lines were studied by methylthiazolyldiphenyl-tetrazolium bromide method and 5-bromo-2-deoxyuridine incorporation assay, respectively. The type of interaction between SAHA and cisplatin was determined by an isobolographic analysis. Western blotting, flow cytometry and quantitative polymerase chain reaction method were used to determine acetylation of histone H3, cell cycle progression and genes expression, respectively. Apoptosis was assessed by means of nucleosomes released to cytosol. Results: SAHA alone or in combination with cisplatin inhibited larynx cancer cells proliferation, whereas displayed relatively low toxicity against normal cells - primary cultures of human skin fibroblasts. The mixture of SAHA with cisplatin exerted additive and synergistic interaction in RK33 and RK45 cells, respectively. We showed that SAHA induced hyperacetylation of histone H3 K9, K14 and K23 and triggered apoptosis. SAHA also caused cell cycle arrest by upregulation of CDKN1A and downregulation of CCND1 encoding p21WAF1/CIP1 and cyclin D1 proteins, respectively. Conclusion: Our studies demonstrated that SAHA may be considered as a potential therapeutic agent against larynx tumors.

  14. Histone Deacetylase Inhibitor SAHA Attenuates TLR4 Signaling in LPS-Stimulated Mouse Macrophages

    PubMed Central

    Chong, Wei; Li, Yongqing; Liu, Baoling; Zhao, Ting; Fukudome, Eugene Y.; Liu, Zhengcai; Smith, William M.; Velmahos, George C.; deMoya, Marc; Alam, Hasan B.

    2012-01-01

    Objective We have previously demonstrated that pre- and post-treatment of animals with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACI), can improve survival in a mouse model of lipopolysaccharides (LPS)-induced severe shock. This study was to assess whether SAHA affects LPS/Toll like receptor4 (TLR4) signaling through acetylation of HSP90 and degradation of its client protein interleukin-1 receptor associated kinase 1 (IRAK1). Methods and Results RAW264.7 cells were exposed to LPS (1 μg/ml) for two hours followed by treatment with SAHA (10 μM) or one of HSP90 inhibitors, geldanamycin (GA) (3 μM). Sham (no SAHA, no LPS) macrophages served as a control. The cells were harvested at different time points, and time zero served as the reference point. LPS dramatically increased protein expression of myeloid differentiation factor 88 (MyD88) and IRAK1, and stimulated nuclear translocation of nuclear factor kB (NF-kB), leading to increases of gene expression and protein production of TNF-α and IL-6. Treatment with SAHA significantly attenuated these LPS- stimulated alterations. LPS or SAHA did not change the levels of HSP90 protein, but immunoprecipitation studies demonstrated that SAHA treatment enhanced acetylation of HSP90, and increased the dissociation of IRAK1, compared to the LPS control. Conclusions SAHA suppresses LPS/TLR4 signaling in LPS-stimulated macrophages through multiple possible mechanisms. It inhibits the function of HSP90 through hyperacetylation of the chaperone protein, which results in dissociation and degradation of the client protein IRAK1 and, at least in part, leads to a resultant decrease in nuclear translocation of NF-κB and attenuation of key pro-inflammatory cytokine expression. PMID:22868051

  15. Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer.

    PubMed

    Konstantinopoulos, Panagiotis A; Wilson, Andrew J; Saskowski, Jeanette; Wass, Erica; Khabele, Dineo

    2014-06-01

    Approximately 50% of serous epithelial ovarian cancers (EOC) contain molecular defects in homologous recombination (HR) DNA repair pathways. Poly(ADP-ribose) polymerase inhibitors (PARPi) have efficacy in HR-deficient, but not in HR-proficient, EOC tumors as a single agent. Our goal was to determine whether the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), can sensitize HR-proficient ovarian cancer cells to the PARPi AZD-2281 (olaparib). Ovarian cancer cell lines (SKOV-3, OVCAR-8, NCI/ADR-Res, UWB1.289 BRCA1null and UWB1.289+BRCA1 wild-type) were treated with saline vehicle, olaparib, SAHA or olaparib/SAHA. Sulforhodamine B (SRB) assessed cytotoxicity and immunofluorescence and Western blot assays assessed markers of apoptosis (cleaved PARP) and DNA damage (pH2AX and RAD51). Drug effects were also tested in SKOV-3 xenografts in Nude mice. Affymetrix microarray experiments were performed in vehicle and SAHA-treated SKOV-3 cells. In a microarray analysis, SAHA induced coordinated down-regulation of HR pathway genes, including RAD51 and BRCA1. Nuclear co-expression of RAD51 and pH2AX, a marker of efficient HR repair, was reduced approximately 40% by SAHA treatment alone and combined with olaparib. SAHA combined with olaparib induced apoptosis and pH2AX expression to a greater extent than either drug alone. Olaparib reduced cell viability at increasing concentrations and SAHA enhanced these effects in 4 of 5 cell lines, including BRCA1 null and wild-type cells, in vitro and in SKOV-3 xenografts in vivo. These results provide preclinical rationale for targeting DNA damage response pathways by combining small molecule PARPi with HDACi as a mechanism for reducing HR efficiency in ovarian cancer. Copyright © 2014. Published by Elsevier Inc.

  16. Suberoylanilide Hydroxamic Acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer

    PubMed Central

    Konstantinopoulos, Panagiotis A.; Wilson, Andrew J.; Saskowski, Jeanette; Wass, Erica; Khabele, Dineo

    2015-01-01

    Objectives Approximately 50% of serous epithelial ovarian cancers (EOC) contain molecular defects in homologous recombination (HR) DNA repair pathways. Poly(ADP-ribose) polymerase inhibitors (PARPi) have efficacy in HR-deficient, but not HR-proficient, EOC tumors as a single agent. Our goal was to determine whether the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), can sensitize HR-proficient ovarian cancer cells to the PARPi AZD-2281 (olaparib). Methods Ovarian cancer cell lines (SKOV-3, OVCAR-8, NCI/ADR-Res, UWB1.289 BRCA1null and UWB1.289 + BRCA1 wild-type) were treated with saline vehicle, olaparib, SAHA or olaparib/SAHA. Sulforhodamine B (SRB) assessed cytotoxicity and immunofluorescence and Western blot assays assessed markers of apoptosis (cleaved PARP) and DNA damage (pH2AX and RAD51). Drug effects were also tested in SKOV-3 xenografts in Nude mice. Affymetrix microarray experiments were performed in vehicle and SAHA-treated SKOV-3 cells. Results In a microarray analysis, SAHA induced coordinated down-regulation of HR pathway genes, including RAD51 and BRCA1. Nuclear co-expression of RAD51 and pH2AX, a marker of efficient HR repair, was reduced approximately 40% by SAHA treatment alone and combined with olaparib. SAHA combined with olaparib induced apoptosis and pH2AX expression to a greater extent than either drug alone. Olaparib reduced cell viability at increasing concentrations and SAHA enhanced these effects in 4 of 5 cell lines, including BRCA1 null and wild-type cells, in vitro and in SKOV-3 xenografts in vivo. Conclusions These results provide preclinical rationale for targeting DNA damage response pathways by combining small molecule PARPi with HDACi as a mechanism for reducing HR efficiency in ovarian cancer. PMID:24631446

  17. Histone Deacetylase Inhibitor SAHA as Potential Targeted Therapy Agent for Larynx Cancer Cells

    PubMed Central

    Grabarska, Aneta; Łuszczki, Jarogniew J.; Nowosadzka, Ewa; Gumbarewicz, Ewelina; Jeleniewicz, Witold; Dmoszyńska-Graniczka, Magdalena; Kowalczuk, Krystyna; Kupisz, Krzysztof; Polberg, Krzysztof; Stepulak, Andrzej

    2017-01-01

    Objective: Laryngeal squamous cell carcinoma is one of the most common malignant tumors in the head and neck region. Due to the poor response to chemotherapeutics in patients and low survival rate, successful treatment of larynx cancer still remains a challenge. Therefore, the identification of novel treatment options is needed. We investigated the anticancer effects of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on two different laryngeal cancer cell lines RK33 and RK45. We also studied the antiproliferative action of SAHA in combination with cisplatin and defined the type of pharmacological interaction between these drugs. Materials and Methods: Viability and proliferation of larynx cancer cell lines were studied by methylthiazolyldiphenyl-tetrazolium bromide method and 5-bromo-2-deoxyuridine incorporation assay, respectively. The type of interaction between SAHA and cisplatin was determined by an isobolographic analysis. Western blotting, flow cytometry and quantitative polymerase chain reaction method were used to determine acetylation of histone H3, cell cycle progression and genes expression, respectively. Apoptosis was assessed by means of nucleosomes released to cytosol. Results: SAHA alone or in combination with cisplatin inhibited larynx cancer cells proliferation, whereas displayed relatively low toxicity against normal cells - primary cultures of human skin fibroblasts. The mixture of SAHA with cisplatin exerted additive and synergistic interaction in RK33 and RK45 cells, respectively. We showed that SAHA induced hyperacetylation of histone H3 K9, K14 and K23 and triggered apoptosis. SAHA also caused cell cycle arrest by upregulation of CDKN1A and downregulation of CCND1 encoding p21WAF1/CIP1 and cyclin D1 proteins, respectively. Conclusion: Our studies demonstrated that SAHA may be considered as a potential therapeutic agent against larynx tumors. PMID:28123594

  18. ISTP CDF Skeleton Editor

    NASA Technical Reports Server (NTRS)

    Chimiak, Reine; Harris, Bernard; Williams, Phillip

    2013-01-01

    Basic Common Data Format (CDF) tools (e.g., cdfedit) provide no specific support for creating International Solar-Terrestrial Physics/Space Physics Data Facility (ISTP/SPDF) standard files. While it is possible for someone who is familiar with the ISTP/SPDF metadata guidelines to create compliant files using just the basic tools, the process is error-prone and unreasonable for someone without ISTP/SPDF expertise. The key problem is the lack of a tool with specific support for creating files that comply with the ISTP/SPDF guidelines. There are basic CDF tools such as cdfedit and skeletoncdf for creating CDF files, but these have no specific support for creating ISTP/ SPDF compliant files. The SPDF ISTP CDF skeleton editor is a cross-platform, Java-based GUI editor program that allows someone with only a basic understanding of the ISTP/SPDF guidelines to easily create compliant files. The editor is a simple graphical user interface (GUI) application for creating and editing ISTP/SPDF guideline-compliant skeleton CDF files. The SPDF ISTP CDF skeleton editor consists of the following components: A swing-based Java GUI program, JavaHelp-based manual/ tutorial, Image/Icon files, and HTML Web page for distribution. The editor is available as a traditional Java desktop application as well as a Java Network Launching Protocol (JNLP) application. Once started, it functions like a typical Java GUI file editor application for creating/editing application-unique files.

  19. Suberoylanilide Hydroxamic Acid (SAHA)-Induced Dynamics of a Human Histone Deacetylase Protein Interaction Network*

    PubMed Central

    Sardiu, Mihaela E.; Smith, Karen T.; Groppe, Brad D.; Gilmore, Joshua M.; Saraf, Anita; Egidy, Rhonda; Peak, Allison; Seidel, Chris W.; Florens, Laurence; Workman, Jerry L.; Washburn, Michael P.

    2014-01-01

    Histone deacetylases (HDACs) are targets for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor approved by the U.S. Food and Drug Administration for the treatment of cutaneous T-cell lymphoma. To obtain a better mechanistic understanding of the Sin3/HDAC complex in cancer, we extended its protein–protein interaction network and identified a mutually exclusive pair within the complex. We then assessed the effects of SAHA on the disruption of the complex network through six homologous baits. SAHA perturbs multiple protein interactions and therefore compromises the composition of large parts of the Sin3/HDAC network. A comparison of the effect of SAHA treatment on gene expression in breast cancer cells to a knockdown of the ING2 subunit indicated that a portion of the anticancer effects of SAHA may be attributed to the disruption of ING2's association with the complex. Our dynamic protein interaction network resource provides novel insights into the molecular mechanism of SAHA action and demonstrates the potential for drugs to rewire networks. PMID:25073741

  20. SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.

    PubMed

    Hanson, Jesse E; La, Hank; Plise, Emile; Chen, Yung-Hsiang; Ding, Xiao; Hanania, Taleen; Sabath, Emily V; Alexandrov, Vadim; Brunner, Dani; Leahy, Emer; Steiner, Pascal; Liu, Lichuan; Scearce-Levie, Kimberly; Zhou, Qiang

    2013-01-01

    Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for other indications. In vivo studies suggest reducing HDAC function can enhance synaptic function and memory, raising the possibility that SAHA treatment could have neurological benefits. We first examined the impacts of SAHA on synaptic function in vitro using rat organotypic hippocampal brain slices. Following several days of SAHA treatment, basal excitatory but not inhibitory synaptic function was enhanced. Presynaptic release probability and intrinsic neuronal excitability were unaffected suggesting SAHA treatment selectively enhanced postsynaptic excitatory function. In addition, long-term potentiation (LTP) of excitatory synapses was augmented, while long-term depression (LTD) was impaired in SAHA treated slices. Despite the in vitro synaptic enhancements, in vivo SAHA treatment did not rescue memory deficits in the Tg2576 mouse model of Alzheimer's disease (AD). Along with the lack of behavioral impact, pharmacokinetic analysis indicated poor brain availability of SAHA. Broader assessment of in vivo SAHA treatment using high-content phenotypic characterization of C57Bl6 mice failed to demonstrate significant behavioral effects of up to 150 mg/kg SAHA following either acute or chronic injections. Potentially explaining the low brain exposure and lack of behavioral impacts, SAHA was found to be a substrate of the blood brain barrier (BBB) efflux transporters Pgp and Bcrp1. Thus while our in vitro data show that HDAC inhibition can enhance excitatory synaptic strength and potentiation, our in vivo data suggests limited brain availability may contribute to the lack of behavioral impact of SAHA following peripheral delivery. These results do not predict CNS effects of SAHA during clinical use and also emphasize the importance of analyzing brain drug levels when interpreting preclinical

  1. Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability

    SciTech Connect

    Zhang, Jingjie; Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Wang, York; Li, Xuejun; Huang, Chuanshu

    2012-09-01

    Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at transcription level or translation level. Here, we have demonstrated that SAHA inhibited EGF-induced Cl41 cell transformation via the decrease of cyclin D1 mRNA stability and induction of G0/G1 growth arrest. We found that SAHA treatment resulted in the dramatic inhibition of EGF-induced cell transformation, cyclin D1 protein expression and induction of G0/G1 growth arrest. Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation. Moreover, SAHA inhibited EGF-induced cyclin d1 mRNA level, whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions, suggesting that SAHA may decrease cyclin D1 mRNA stability. This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability. Thus, our study identifies a novel mechanism responsible for SAHA inhibiting cell transformation via decreasing cyclin D1 mRNA stability and induction of G0/G1 growth arrest in Cl41 cells. -- Highlights: ► SAHA inhibits cell transformation in Cl41 cells. ► SAHA suppresses Cyclin D1 protein expression. ► SAHA decreases cyclin D1 mRNA stability.

  2. [Jonathan Swift's scientific contribution on his "Gulliver's Travels"].

    PubMed

    Miranda C, Marcelo; Pérez J, Carolina; Slachevsky Ch, Andrea

    2011-03-01

    Jonathan Swift is one of the most celebrated satirist writers in literature. His well-known "Gulliver's Travels", apart from being a serious human being criticism, contains many interesting ana unrecognized comments about medical and other scientific facts. Swift made what seems to be the first account of a dementing illness in the elderly; his description fits well with what we now know as Alzheimer's disease. He also described a condition now called synaesthesia, a very interesting phenomenon that may contribute to creativity. In this paper, we review aspects of his life and reveal these amazing descriptions as samples of Swift's extraordinary power of observation.

  3. Histone Deacetylase Inhibitor SAHA Is a Promising Treatment of Cushing Disease.

    PubMed

    Lu, Jie; Chatain, Grégoire P; Bugarini, Alejandro; Wang, Xiang; Maric, Dragan; Walbridge, Stuart; Zhuang, Zhengping; Chittiboina, Prashant

    2017-08-01

    Remission failure following transsphenoidal surgery in Cushing disease (CD) from pituitary corticotroph tumors (CtTs) remains clinically challenging. Histone deacetylase inhibitors (HDACis) are antitumor drugs approved for clinical use, with the potential to affect adrenocorticotropin hormone (ACTH) hypersecretion by inhibiting pro-opiomelanocortin (POMC) transcription. Testing the efficacy of suberoylanilide hydroxamic acid (SAHA) on human and murine ACTH-secreting tumor (AtT-20) cells. Cell viability, ACTH secretion (enzyme-linked immunosorbent assay), apoptosis, and gene expression profile were investigated on AtT-20 cells. In vivo efficacy was examined in an athymic nude mouse AtT-20 xenograft model. SAHA efficacy against human-derived corticotroph tumor (hCtT) (n = 8) was tested in vitro. National Institutes of Health. SAHA (0.5 to 8 µM). AtT-20 and hCtT cell survival, in vitro/invivo ACTH measurements. SAHA (1 µM) reduced AtT-20 viability to 75% at 24 hours, 43% at 48 hours (analysis of variance; P = 0.002). Apoptosis was confirmed with elevated BAX/Bcl2 ratio and FACS. Intriguingly, early (3-hour) significant decline (70%; P < 0.0001) of secreted ACTH and diminished POMC transcription was observed with SAHA (1 µM). Microarray analysis revealed a direct association between liver X receptor alpha (LXRα) and POMC expression. Accordingly, SAHA reduced LXRα in AtT-20 cells but not in normal murine corticotrophs. Xenografted nude-mice tumor involution (126 ± 33/160 ± 35 vs 337 ± 49 mm3; P = 0.0005) was observed with 5-day intraperitoneal SAHA, with reversal of elevated ACTH (P < 0.0001). SAHA did not affect serum ACTH in nontumor mice. Lastly, we confirmed that SAHA (1 µM/24 h) decreased hCtT survival (78.92%; P = 0.0007) and ACTH secretion (83.64%; P = 0.03). Our findings demonstrate SAHA's efficacy in reducing survival and ACTH secretion in AtT-20 and hCtT cells, providing a potential intervention for recurrent/unremitting CD.

  4. A century of editors.

    PubMed

    Riley, R W

    1983-07-08

    They are unalike and far apart, these 13 past editors of The Journal. Between Nathan S. Davis's first issue and William R. Barclay's retirement, there was almost a century of change in medicine, society, the American Medical Association, prose style, and editorial needs. During these years, the editors ranged from the brilliant organizers John B. Hamilton and George H. Simmons to the diligent John H. Hollister and the devoted Johnson F. Hammond. There were editors with the hot determination of James C. Culbertson, John H. Talbott, and Robert H. Moser, and there were those with the cool precision of Austin Smith and Hugh H. Hussey. They varied from Morris Fishbein, who wrote and spoke "with the grade of an eagle in its unhindered soar," to Truman W. Miller, who wrote scarcely a word. Here, briefly, they are together.

  5. PANEL LIBRARY AND EDITOR

    NASA Technical Reports Server (NTRS)

    Raible, E.

    1994-01-01

    The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and

  6. MSSP Associate Editors

    NASA Astrophysics Data System (ADS)

    Mottershead, John E.

    2015-08-01

    MSSP is pleased to announce the appointment of three distinguished researchers, Professors Jerome Antoni, Spilios Fassois and Paolo Pennacchi, as Associate Editors. The broad coverage of MSSP research topics demands editorial expertise in several disciplines and the appointment of an editorial team of the highest quality is essential in maintaining and further enhancing the reputation of MSSP as a journal at the forefront of modern experimental mechanics that combines dynamic systems with measurement technology, signal processing and active control. Brief descriptions of the backgrounds and experience of the Associate Editors are provided in the following paragraphs.

  7. PANEL LIBRARY AND EDITOR

    NASA Technical Reports Server (NTRS)

    Raible, E.

    1994-01-01

    The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and

  8. Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin.

    PubMed

    Kuzelová, Katerina; Pluskalová, Michaela; Brodská, Barbora; Otevrelová, Petra; Elknerová, Klára; Grebenová, Dana; Hrkal, Zbynek

    2010-01-01

    Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) which is being introduced into clinic for the treatment of hematological diseases. We studied the effect of this compound on six human hematopoietic cell lines (JURL-MK1, K562, CML-T1, Karpas-299, HL-60, and ML-2) as well as on normal human lymphocytes and on leukemic primary cells. SAHA induced dose-dependent and cell type-dependent cell death which displayed apoptotic features (caspase-3 activation and apoptotic DNA fragmentation) in most cell types including the normal lymphocytes. At subtoxic concentrations (0.5-1 microM), SAHA increased the cell adhesivity to fibronectin (FN) in all leukemia/lymphoma-derived cell lines but not in normal lymphocytes. This increase was accompanied by an enhanced expression of integrin beta1 and paxillin, an essential constituent of focal adhesion complexes, both at the protein and mRNA level. On the other hand, the inhibition of ROCK protein, an important regulator of cytoskeleton structure, had no consistent effect on SAHA-induced increase in the cell adhesivity. The promotion of cell adhesivity to FN seems to be specific for SAHA as we observed no such effects with other HDAC inhibitors (trichostatin A and sodium butyrate).

  9. Jonathan Mann, HIV/AIDS, and human rights.

    PubMed

    Fee, Elizabeth; Parry, Manon

    2008-04-01

    The early association of HIV/AIDS with marginal groups - homosexuals and IV drug users - structured social and political responses to the disease. Many countries began to enact restrictive travel policies and to contemplate compulsory testing or quarantine for those infected. In Africa, Jonathan Mann became convinced that the disease was heterosexually transmitted and had the potential to become a worldwide pandemic. He convinced Halfden Mahler, Director General of WHO, who appointed him director of the WHO's Global Programme on AIDS. In this position, and because of his eloquence and passion, Mann was able to mobilize ministers of health around the world. Mann argued that AIDS was a social disease, flourishing in conditions of poverty, oppression, urban migration, gender inequality, and violence. He advanced a new way of understanding AIDS and AIDS policies based on a human rights framework.

  10. Editors' Spring Picks

    ERIC Educational Resources Information Center

    Library Journal, 2011

    2011-01-01

    While they do not represent the rainbow of reading tastes American public libraries accommodate, Book Review editors are a wildly eclectic bunch. One look at their bedside tables and ereaders would reveal very little crossover. This article highlights an eclectic array of spring offerings ranging from print books to an audiobook to ebook apps. It…

  11. Editor's message: Student involvement

    Treesearch

    Bill Block

    2012-01-01

    In the initial Editor's Message of this volume, I stated my intent to involve more students in the publication process. A number of people commented on it being a good idea, but only a couple have followed up. One was Paul Krausman, President of The Wildlife Society. We matched graduate students from the University of Montana wildlife program with manuscripts...

  12. Editors' Fall Picks

    ERIC Educational Resources Information Center

    Heilbrun, Margaret; McCormack, Heather; Katterjohn, Anna; Kuzyk, Raya; Roncevic, Mirela; Fox, Bette-Lee; Hoffert, Barbara

    2009-01-01

    "Library Journal's" review editors select fall titles readers won't want to miss--"Waiting on a Train: The Embattled Future of Passenger Rail Service" (James McCommons); "Happy" (Alex Lemon); "Free for All: Joe Papp, the Public, and the Greatest Theater Story Ever Told" (Kenneth Turan & Joseph Papp); "In My Father's Shadow: A Daughter Remembers…

  13. LDAP Browser/Editor

    SciTech Connect

    Gawor, Jarek; Laszewski, Gregor von

    2000-07-18

    The LDAP Browser/Editor provides a user-friendly Java-based interface to LDAP databases with tightly integrated browsing and editing capabilities. Entirely written in Java with help of the JFC (Swingset) and JNDI class libraries. It connects to any X.500, LDAP v2 and v3 servers and supports editing of multiple-value attributes.

  14. Editors' Spring Picks

    ERIC Educational Resources Information Center

    Library Journal, 2011

    2011-01-01

    While they do not represent the rainbow of reading tastes American public libraries accommodate, Book Review editors are a wildly eclectic bunch. One look at their bedside tables and ereaders would reveal very little crossover. This article highlights an eclectic array of spring offerings ranging from print books to an audiobook to ebook apps. It…

  15. WRR editor Ronald Cummings

    NASA Astrophysics Data System (ADS)

    1984-04-01

    It has been nearly a year since Ronald Cummings took over as policy sciences editor of Water Resources Research (WRR), and in that time he has worked to make the journal live up to its role as “an interdisciplinary journal integrating research in the social and natural sciences of water.” Cummings takes the “interdisciplinary” part seriously. “I'd like to see a much broader range of policy issues presented to readers,” he says. “I would hope it would then stimulate interchange between our colleagues concerning evolving issues of the '80s and '90s.”Cummings brings a solid background as a resource economist to his 4-year term as editor, which began last January and runs until December 1987. Cummings succeeds Jared Cohon as policy sciences editor. Stephen J. Burges is the WRR editor for hydrological, physical, chemical, and biological sciences. Now a Professor of Economics and Director of the Program in Natural Resources Economics at the University of New Mexico, Cummings is a past president of the Association of Environmental and Resource Economists. He has been a consultant in matters of water resources management, forestry management, and energy policy for more than a decade, working on projects in both the United States and Latin America. Since joining the faculty at New Mexico in 1975, he has, among other things, worked with engineers at the Los Alamos National Laboratory in developing operation'management models for hot, dry rock geothermal systems.

  16. Editors' Fall Picks

    ERIC Educational Resources Information Center

    Heilbrun, Margaret; McCormack, Heather; Katterjohn, Anna; Kuzyk, Raya; Roncevic, Mirela; Fox, Bette-Lee; Hoffert, Barbara

    2009-01-01

    "Library Journal's" review editors select fall titles readers won't want to miss--"Waiting on a Train: The Embattled Future of Passenger Rail Service" (James McCommons); "Happy" (Alex Lemon); "Free for All: Joe Papp, the Public, and the Greatest Theater Story Ever Told" (Kenneth Turan & Joseph Papp); "In My Father's Shadow: A Daughter Remembers…

  17. Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA)

    PubMed Central

    Mahlum, Amy; Mehraein-Ghomi, Farideh; Kegel, Stacy J.; Guo, Song; Peters, Noel R.; Wilding, George

    2013-01-01

    Purpose Most prostate, colon and breast cancer cells are resistant to growth inhibitory effects of suberoylanilide hydroxamic acid (SAHA). We have examined whether the high oxidative stress in these cells causes a loss of SAHA activity and if so, whether pretreatment with an anti-oxidant can sensitize these cells to SAHA. Methods A DNA-Hoechst dye fluorescence measured cell growth and dichlorfluorescein-diacetate (DCF-DA) dye fluorescence measured reactive oxygen species (ROS). Growth inhibitory and ROS-generating activities of SAHA in androgen-treated or untreated LNCaP cells and PC-3 prostate cancer cells, HT-29 and HCT-115 colon cancer cells, MDA-MB231 breast cancer cells and A549 and NCI-H460 lung cancer cells with or without pretreatment with an anti-oxidant Vitamin E was determined. SAHA activity against LNCaP cells treated with another anti-oxidant N-acetyl cysteine (NAC) was also determined. Liquid chromatography–mass spectrometry (LC–MS) was used to determine intracellular SAHA level. Results SAHA treatment markedly inhibits LNCaP cell growth, when the cells are at a low ROS level. SAHA is, however, inactive against the same cell line, when the cells are at a high ROS level. A significant decrease in SAHA level was observed in LNCaP cells with high ROS after 24-and 72-h treatment when compared to cells with low ROS. Vitamin E pretreatment that reduces cellular ROS, synergistically sensitizes oxidatively stressed LNCaP, PC-3, HT-29, HCT-115 and MDA-MB231 cells, but not the A-549 and NCI-H460 cells with low ROS to SAHA. NAC treatment also sensitized androgen-treated LNCaP cells to the growth inhibitory effects of SAHA. Conclusion Response to SAHA could be improved by combining anti-oxidants such as Vitamin E with SAHA for the treatment of oxidatively stressed human malignancies that are otherwise resistant to SAHA. PMID:20512578

  18. Guest Editors' Preface

    NASA Astrophysics Data System (ADS)

    Gille, Peter; Miller, Wolfram; Sangwal, Keshra; Talik, Ewa

    2014-09-01

    The 17th International Conference on Crystal Growth and Epitaxy (ICCGE-17) was held in Warsaw during 11 and 16 August 2013. The contributions during the ICCGE-17 were of three types: Invited lectures, oral presentations and poster presentions. The conference participants were also invited to submit manuscripts based on their contributions for publication in the ICCGE-17 Proceedings volume of Journal of Crystal Growth. The present volume contains manuscripts accepted by the guest editors for this conference volume.

  19. Writers, Editors, and Computer,

    DTIC Science & Technology

    1980-07-01

    future will be for publishers, writers, and editors; it’s usually quite a different matter to make those dreams come true. Occasionally others will say...resources that are completely operational today; there is usually quite a gap between that reality and our dreams ! I’ve spent some time recently trying...AND COMPUTERS. Availability Codes Alo ail Constance U. Greaser list SP~oaJ~\\Head, Publications Department ,tseasy to dream about how marvelous the

  20. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1997-03-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Criticisms of hands-on pseudoscience David J Fisher 27 Elderberry Road, Cardiff CF5 3RG, UK Measuring varying fields Don Koks Adelaide University, Australia Relativity at A-level: a comment David Sang 3 Ellasdale Road, Bognor Regis, PO21 2SG, UK

  1. ION Configuration Editor

    NASA Technical Reports Server (NTRS)

    Borgen, Richard L.

    2013-01-01

    The configuration of ION (Inter - planetary Overlay Network) network nodes is a manual task that is complex, time-consuming, and error-prone. This program seeks to accelerate this job and produce reliable configurations. The ION Configuration Editor is a model-based smart editor based on Eclipse Modeling Framework technology. An ION network designer uses this Eclipse-based GUI to construct a data model of the complete target network and then generate configurations. The data model is captured in an XML file. Intrinsic editor features aid in achieving model correctness, such as field fill-in, type-checking, lists of valid values, and suitable default values. Additionally, an explicit "validation" feature executes custom rules to catch more subtle model errors. A "survey" feature provides a set of reports providing an overview of the entire network, enabling a quick assessment of the model s completeness and correctness. The "configuration" feature produces the main final result, a complete set of ION configuration files (eight distinct file types) for each ION node in the network.

  2. Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).

    PubMed

    Spiller, Susan E; Ditzler, Sally H; Pullar, Barbara J; Olson, James M

    2008-04-01

    Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been given safely to children, and achieve brain concentrations that are at or near therapeutic levels. Retinoic acid acts by transcriptionally activating bone morphogenetic protein-2 (BMP-2) and SAHA facilitates transcriptional activity through chromatin accessibility. We tested the hypothesis that these drugs additively induce BMP-2 transcription and apoptosis. RA + SAHA induction of BMP-2 transcription and apoptosis in medulloblastoma cultures was evaluated. Subsequently the response of mouse medulloblastomas to these two agents in the presence and absence of cisplatin was evaluated. BMP-2 transcription multiplied 3-fold with addition of RA to culture, and 7-fold with both agents. The IC50 of SAHA was reduced by 40% when low dose RA was added. Interestingly, a p38 MAP kinase inhibitor that partially blocks RA-induced apoptosis did not inhibit the activity of RA + SAHA. Flank D283 tumors in athymic mice had slower growth in the RA + SAHA arm than single drug or control arms. Intracranial tumors in ND2:SmoA1 mice treated with RA + SAHA + cisplatin showed a 4-fold increase in apoptosis over controls, and a 2-fold increase over animals receiving only SAHA or RA + SAHA. RA + SAHA additively induce BMP-2 transcription and medulloblastoma apoptosis. The combination may act through a p38 MAPK independent mechanism. Efficacy increased with cisplatin, which has implications for clinical trial design.

  3. Jonathan Swift (1667-1745): master satirist, eccentric dean and frustrated lover.

    PubMed

    Carter, Richard

    2007-08-01

    Jonathan Swift, Irish author and poet, became an Anglican Dean with a macabre interest in medicine. He wrote 'Verses on the Death of Dr Swift' predicting how his death would be received in Dublin and London.

  4. Straight talk with...Jonathan Quick. Interview by Roxanne Khamsi.

    PubMed

    Quick, Jonathan

    2013-09-01

    In April 2012, an e-mail announcing the impending closure of the Global Health Council following the cancellation of its annual conference sent shockwaves through its community of 325 organizational members spanning 39 countries. For 40 years, the Alexandria, Virginia-based nonprofit had acted as an umbrella organization for stakeholders that include some of the world's most prominent medical institutions and drug companies. As the June 2012 closure of the GHC approached, several members stepped in to rescue the operation, including Jonathan Quick, a family physician and CEO of Management Sciences for Health, a Cambridge, Massachusetts-based outfit that works to strengthen health systems and infrastructure around the globe. In January, a new GHC board was elected, with Quick at the helm. In the ensuing months the board members have built the organization back up-albeit as a leaner and more targeted operation. This past summer, they launched a revamped website (www.globalhealth.org) and are looking ahead to convening GHC members at the UN General Assembly on 18 September in New York, where the discussion of Millennium Development Goals will take place. As Nature Medicine went to press, the relaunched GHC was in the midst of recruiting for its first staff position, executive director. Roxanne Khamsi spoke with Quick about the health of the organization.

  5. EDITORIAL: Editor's Farewell

    NASA Astrophysics Data System (ADS)

    Hudson, R. P.

    1989-01-01

    The completion of Volume 26, 1989, marked the end of my tenure as Editor of Metrologia. My association with the journal, its parent body the Comité International des Poids et Mesures, its host organization the Bureau International des Poids et Mesures, the publishers Springer-Verlag and last (but by no means least) the Editorial Board, has been a pleasant one and I trust that the subscribers will have found the product to be generally satisfactory. There have been, it is true, some disappointments along the way and I shall mention two of these while expressing the hope that the new Editor will enjoy a greater success in their regard. First is the question of circulation, which has stayed dangerously low, although the shrinkage has tapered off in the most recent years. Because of the narrow public support, the costs of production are relatively high and this, through a consequently high subscription rate, tends to enshrine the unsatisfactory state of affairs. Modest schemes to broaden the journal's appeal and bring in a wider readership have foundered upon the first step, namely, that of procuring from staff members of the national standards laboratories the hoped-for articles which would discuss the state of the art in delivering the highest-quality measurement services to the public. However, some very interesting and bolder schemes are presently under discussion. I had also hoped to leaven the journal's content a little by regularly appearing articles on the latest developments within the great national laboratories. But, as with technical review articles, it has proven very difficult to find the right authors who can also spare the time, and only a few laboratories have found it possible to collaborate. In taking my leave, it remains for me to thank all the contributors, referees and readers for their support, to express the hope of an ever brighter future for Metrologia and to wish to the new Editor, Dr D A Blackburn, a happy and successful tenure.

  6. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1998-01-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Physics and history Arthur I Miller Department of Science & Technology Studies, University College London, Gower Street, London WC1E 6BT, UK Physics and history: a reply David Miller Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK Cathode rays, the electron and Thomson's discovery John Harris 33 Glentham Road, London SW13 9JD, UK Vectors: swallow them whole! David Wheeler Mahanakorn University of Technology, Bangkok, Thailand

  7. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1998-03-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Comment on `Magnetic and electric field strengths of high voltage power lines and household appliances' José Luis Giordano Dept. de Ciencia y Tecnología de Materiales y Fluidos, CPSI, Universidad de Zaragoza, Spain Twins paradox S R Carson Norton College, Malton, North Yorkshire, UK On alternative ways of finding the ratio of specific heats of gases Tomas Ficker Physics Department, Technical University of Brno, Czech Republic

  8. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1998-09-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Science spreadsheets Richard Beare Institute of Education, University of Warwick, Coventry, UK Calculating the `lost energy' Zhang Yongzhao and Zhang Shuyan Police Frontier Guard Patrol Boat Institute, Zhejiang, Ningbo 315801, People's Republic of China Cartesian diver solves the inverse sprinkler problem Boris M Valiyov and Vladimir D Yegorenkov Department of Physics, Kharkov State University, 4 Svobody sq., 310077, Kharkov, Ukraine Update excellence Karen Barker Lytham St Annes, Lancs, UK

  9. Letters to the Editor

    NASA Astrophysics Data System (ADS)

    1997-01-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Software teaching of modular physics: SToMP Stephen Hearn Head of Science, Charterhouse, Godalming, Surrey GU7 2DX Bridging the gap or avoiding a chasm? R W West York Strengths and weaknesses of science John Bausor Christians in Science Education, Edgware, London HA8 6RR Addressing the issues Philip Britton Head of Physics, Leeds Grammar School Modern syllabuses and old textbooks: a useful synthesis Richard Barrass St Mary's College, Doncaster DN1 2ES

  10. Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model

    PubMed Central

    Li, Xinyu; Zhou, Qinbo; Hanus, Jakub; Anderson, Chastain; Zhang, Hongmei; Dellinger, Michael; Brekken, Rolf; Wang, Shusheng

    2013-01-01

    Neovascularization (NV) in the cornea is a major cause of vision impairment and corneal blindness. Hemangiogenesis and lymphangiogenesis induced by inflammation underlie the pathogenesis of corneal NV. The current mainstay treatment, corticosteroid, treats the inflammation associated with corneal NV, but is not satisfactory due to such side effects as cataract and the increase in intraocular pressure. It is imperative to develop a novel therapy that specifically targets the hemangiogenesis, lymphangiogenesis and inflammation pathways underlying corneal NV. Histone deacetylase inhibitors (HDACi) have been in clinical trials for cancer and other diseases. In particular, HDACi suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza) has been approved by the FDA for the treatment of cutaneous T-cell lymphoma. The functional mechanism of SAHA in cancer and especially in corneal NV remains unclear. Here, we show that topical application of SAHA inhibits neovascularization in an alkali-burn corneal injury model. Mechanistically, SAHA inhibits corneal NV by repressing hemangiogenesis, inflammation pathways and previously overlooked lymphangiogenesis. Topical SAHA is well tolerated on the ocular surface. In addition, the potency of SAHA in corneal NV appears to be comparable to the current steroid therapy. SAHA may possess promising therapeutic potential in alkali-burn corneal injury and other inflammatory neovascularization disorders. PMID:23186311

  11. SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture.

    PubMed

    Arhoma, A; Chantry, A D; Haywood-Small, S L; Cross, N A

    2017-09-08

    Multiple Myeloma (MM) is currently incurable despite many novel therapies. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a potential anti-tumour agent although effects as a single agent are limited. In this study, we investigated whether the Histone Deacetylase (HDAC) inhibitor SAHA can enhance TRAIL-induced apoptosis and target TRAIL resistance in both suspension culture, and 3D cell culture as a model of disseminated MM lesions that form in bone. The effects of SAHA and/or TRAIL in 6 Multiple Myeloma cell lines were assessed in both suspension cultures and in an Alginate-based 3D cell culture model. The effect of SAHA and/or TRAIL was assessed on apoptosis by assessment of nuclear morphology using Hoechst 33342/Propidium Iodide staining. Viable cell number was assessed by CellTiter-Glo luminescence assay, Caspase-8 and -9 activities were measured by Caspase-Glo™ assay kit. TRAIL-resistant cells were generated by culture of RPMI 8226 and NCI-H929 by acute exposure to TRAIL followed by selection of TRAIL-resistant cells. TRAIL significantly induced apoptosis in a dose-dependent manner in OPM-2, RPMI 8226, NCI-H929, U266, JJN-3 MM cell lines and ADC-1 plasma cell leukaemia cells. SAHA amplified TRAIL responses in all lines except OPM-2, and enhanced TRAIL responses were both via Caspase-8 and -9. SAHA treatment induced growth inhibition that further increased in the combination treatment with TRAIL in MM cells. The co-treatment of TRAIL and SAHA reduced viable cell numbers all cell lines. TRAIL responses were further potentiated by SAHA in 3D cell culture in NCI-H929, RPMI 8226 and U266 at lower TRAIL + SAHA doses than in suspension culture. However TRAIL responses in cells that had been selected for TRAIL resistance were not further enhanced by SAHA treatment. SAHA is a potent sensitizer of TRAIL responses in both TRAIL sensitive and resistant cell lines, in both suspension and 3D culture, however SAHA did not sensitise TRAIL-sensitive cell

  12. New TOR editor

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    1984-04-01

    David A. Brooks, associate professor at Texas A&M University's oceanography department, has been appointed editor designate of The Oceanography Report (TOR). He succeeds Arnold L. Gordon of the Lamont-Doherty Geological Observatory. Gordon, who initiated TOR in September 1981, is the new president-elect of the AGU Ocean Sciences Section.Brooks, a physical oceanographer, has been at Texas A&M for 6 years. His research interests include waves and tides, the interaction of waves and currents, Gulf Stream fluctuations, and Gulf of Mexico and Gulf of Maine circulation. Before going to Texas A&M, Brooks was a research associate and graduate faculty member at North Carolina State University in Raleigh.

  13. EDITORIAL: Editor's Introduction

    NASA Astrophysics Data System (ADS)

    Blackburn, D. A.

    1990-01-01

    Since its first issue in 1965 Metrologia has had just three editors, a history of tenure which suggests that those who hold the post find in it sufficient to interest, occupy, challenge and amuse them. I see no reason to doubt that this happy circumstance will continue and look forward to my own period as editor with the intention of retaining, insofar as I am able to interpret them, the best traditions the journal has established so far. As I take up my editorial duties I have become aware that surrounding Metrologia there is a small community of authors, reviewers and readers on whose support the success of the journal entirely depends. It is a community in which the roles change daily with some of its members engaged, even simultaneously, as reader, reviewer and author. I am well aware that the goodwill extended to me as I enter this community is in no small part due the efforts of the outgoing editor, Dr Ralph Hudson, whose easy, engaging and courteous, yet firm, relationship with authors and reviewers emerges clearly from editorial correspondence. I thank him for that he has done and wish him an active and happy retirement. A short foray into the records of Metrologia shows - in the first editorial - that four main kinds of article were originally envisaged: research articles likely to contribute to progress in fundamental scientific measurements, reports of experiments or techniques of particular importance or originality in the area of secondary measurement, articles concerning the decisions of the Comité International des Poids et Mesures, and review articles. No balance was specified but a priority was assigned to articles dealing with fundamental metrology. Of the four categories, the first two represent the core of Metrologia's activity and largely determine its reputation as a publication. For this reason, editorial implementation of the policy set by the CIPM is mainly exercised through the operation of a reviewing system which is intentionally strict

  14. Message from the Editor

    NASA Astrophysics Data System (ADS)

    Stambaugh, Ronald D.

    2014-01-01

    This last year being an odd numbered year, the pages of Nuclear Fusion saw a large influx of expanded papers from the 2012 Fusion Energy Conference in San Diego. Many papers have focused on the scientific and technical challenges posed by ITER. Contributions are steadily increasing from the new superconducting tokamaks in Asia. The ITER Project continues to move ahead. Construction at the Cadarache site is quite remarkable. Buildings completed include the huge Poloidal Field Coils Winding Facility and the Headquarters building, which has been occupied by the ITER staff. Work is progressing on the Assembly building and the Cryostat Workshop. The base of the tokamak complex is being laid. Besides the construction that is taking place and will take place at the site, components from around the world have to navigate the complex route from Marseilles to the site. A test convoy replicating the dimensions and weights of the most exceptional ITER loads successfully traversed that route in 2013. We are pleased to report that the IAEA and ITER have finalized the agreement for ITER authors to publish papers in Nuclear Fusion . Nuclear Fusion is proud to continue its key role in providing the leading forum for the documentation of scientific progress and exchange of research results internationally toward fusion energy. Refereeing The Nuclear Fusion editorial office appreciates greatly the effort made by our referees to sustain the high quality of the journal. Since January 2005, we have been offering the most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in previous years. The following people have been selected: J.M. Canik, Oak Ridge National Laboratory, USA I.T. Chapman, Culham Centre for Fusion Energy, UK L.-G. Eriksson, Commission of the European Communities, Belgium T. Evans

  15. Microbial Properties Database Editor Tutorial

    EPA Science Inventory

    A Microbial Properties Database Editor (MPDBE) has been developed to help consolidate microbial-relevant data to populate a microbial database and support a database editor by which an authorized user can modify physico-microbial properties related to microbial indicators and pat...

  16. Editors in the Electronic Age.

    ERIC Educational Resources Information Center

    Dye, Robert M., Ed.

    Intended for newspaper writers and editors, this collection of articles includes the following titles and authors: "VDTs, TV Haven't Shocked Editors" by Jay Rogers; "Opinions Vary on Electronics' Effect" by Bob Nordyke; "A Few Kind Words for the Censors" by Hugh A. Mulligan; "Those Awards Have Their Limitations" by Larry Fortner; "Obituaries Are…

  17. Microbial properties database editor tutorial

    USDA-ARS?s Scientific Manuscript database

    A Microbial Properties Database Editor (MPDBE) has been developed to help consolidate microbialrelevant data to populate a microbial database and support a database editor by which an authorized user can modify physico-microbial properties related to microbial indicators and pathogens. Physical prop...

  18. Microbial Properties Database Editor Tutorial

    EPA Science Inventory

    A Microbial Properties Database Editor (MPDBE) has been developed to help consolidate microbial-relevant data to populate a microbial database and support a database editor by which an authorized user can modify physico-microbial properties related to microbial indicators and pat...

  19. GUEST EDITORS' INTRODUCTION: Guest Editors' introduction

    NASA Astrophysics Data System (ADS)

    Coulson, Geoff; de Meer, Jan B.

    1997-03-01

    . Their scheme is embedded in an experimental ATM network with the potential for guaranteed QoS. The system features QoS support mechanisms in both the network and the end systems. Of particular interest is reported experience with a dynamic QoS adaptation protocol implemented in the network and based on video scaling techniques and filtering. In summary, this special issue provides an up to date review of approaches to QoS management and their practical realization. Of course, no claim is made as to comprehensiveness, but the chosen papers do serve as a highly representative sample of current directions in QoS research. The editors are very much obliged to all authors, reviewers and publishers. Without their excellent work, and the contribution of their valuable time this special issue would not have been possible.

  20. Radiosensitization by SAHA in Experimental Colorectal Carcinoma Models-In Vivo Effects and Relevance of Histone Acetylation Status

    SciTech Connect

    Folkvord, Sigurd; Ree, Anne Hansen; Furre, Torbjorn; Halvorsen, Thomas; Flatmark, Kjersti

    2009-06-01

    Purpose: Histone deacetylase inhibitors are being evaluated as antitumor agents in ongoing clinical trials, and promising preclinical results, combined with favorable toxicity profiles, have rendered the drugs as interesting candidates for combination with other treatment modalities, such as radiotherapy. The aim of the present study was to evaluate the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) and the possible requirement of histone hyperacetylation at radiation exposure. Methods and materials: Radiosensitization by SAHA was assessed in a colorectal carcinoma cell line and in two colorectal xenograft models by analysis of clonogenic survival and tumor growth delay, respectively. Histone acetylation status at radiation exposure was evaluated by Western blot. Results: In vitro, radiosensitization was demonstrated when cells were preincubated with SAHA, and, in the xenografts, tumor growth was delayed when the mice were treated with fractionated radiation combined with daily SAHA injections compared with radiation alone. Surprisingly, the SAHA-dependent growth delay was still present when radiation was delivered at restored baseline acetylation levels compared with maximal histone hyperacetylation. Conclusion: SAHA was an effective radiosensitizer in experimental colorectal carcinoma models, suggesting that histone deacetylase inhibition might constitute a valuable supplement to current multimodal treatment strategies in rectal cancer. The presence of histone hyperacetylation at radiation was not required to obtain an increased radiation response, questioning the validity of using histone hyperacetylation as a molecular marker for radiosensitivity.

  1. SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells

    PubMed Central

    Bu, Qiangui; Cui, Lijing; Li, Juan; Du, Xin; Zou, Waiyi; Ding, Ke; Pan, Jingxuan

    2014-01-01

    Limited treatment options are available for chronic myelogenous leukemia (CML) patients who develop imatinib mesylate (IM) resistance. Here we proposed a novel combination regimen, a co-administration of S116836, a novel small molecule multi-targeted tyrosine kinase inhibitor that was synthesized by rational design, and histone deacetylases inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA), to overcome IM resistance in CML. S116836 at low concentrations used in the present study mildly downregulates auto-tyrosine phosphorylation of Bcr-Abl. SAHA, an FDA-approved HDACi drug, at 1 μM has modest anti-tumor activity in treating CML. However, we found a synergistic interaction between SAHA and S116836 in Bcr-Abl-positive CML cells that were sensitive or resistant to IM. Exposure of KBM5 and KBM5-T315I cells to minimal or non-toxic concentrations of SAHA and S116836 synergistically reduced cell viability and induced cell death. Co-treatment with SAHA and S116838 repressed the expressions of anti-apoptosis proteins, such as Mcl-1 and XIAP, but promoted Bim expression and mitochondrial damage. Of importance, treatment with both drugs significantly reduced cell viability of primary human CML cells, as compared with either agent alone. Taken together, our findings suggest that SAHA exerts synergistically with S116836 at a non-toxic concentration to promote apoptosis in the CML, including those resistant to imatinib or dasatinib. PMID:24759597

  2. Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia.

    PubMed

    Sun, Xiaoshen; Hasanali, Zainul S; Chen, Allshine; Zhang, Dianzheng; Liu, Xin; Wang, Hong-Gang; Feith, David J; Loughran, Thomas P; Xu, Kailin

    2015-02-01

    Natural killer (NK) large granular lymphocyte (LGL) leukaemia features a clonal proliferation of CD3(-) NK cells that can be classified into either aggressive or chronic categories. The NKL cell line, derived from an aggressive Asian NK cell leukaemia, and patient samples from chronic NK-LGL leukaemia were used in our study to probe for synergistic efficacy of the epigenetic drugs vorinostat (SAHA) and cladribine in this disease. We demonstrate that histone deacetylases (HDACs) are over-expressed in both aggressive and chronic NK leukaemia. Administration of the HDAC inhibitor SAHA reduces class I and II HDAC expression and enhances histone acetylation in leukaemic NK cells. In vitro combination treatment with SAHA and cladribine dose-dependently exerts synergistic cytotoxic and apoptotic effects on leukaemic NK cells. Expression profiling of apoptotic regulatory genes suggests that both compounds led to caspase-dependent apoptosis through activation of intrinsic mitochondrial and extrinsic death receptor pathways. Collectively, these data show that combined epigenetic therapy, using HDAC and DNA methyltransferase inhibitors, may be a promising therapeutic approach for NK-LGL leukaemia. © 2014 John Wiley & Sons Ltd.

  3. Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Strassmeier, Klaus G.

    2008-01-01

    As of 2006, Astronomische Nachrichten -- Astronomical Notes has reached its all-time high regarding the ISI journal impact factor, with an impressive increase of 60% compared to 2005. We now rank at position 1,399, as shown in the statistics below. This is solely due to the increased number and quality of published articles: In 2006, Astronomische Nachrichten -- Astronomical Notes published 208 research papers and received 1,033 citations -- five citations per paper on average. In 2007, we have published 177 research papers, and one may be curious to see how their factor will develop. In co-operation with Wiley InterScience we have achieved an average o nline publication time of just 4.5 months. As in the past, publication in Astronomische Nachrichten -- Astronomical Notes} continues to be free of charge. Also, all articles of the first issue of each volume can be downloaded free of charge, as can all articles labelled ``Editor's Choice'', which are additionally featured with a color image on the front cover.

  4. Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Strassmeier, Klaus G.

    2009-01-01

    As of 2007, Astronomische Nachrichten -- Astronomical Notes has reached its all-time high regarding the ISI journal impact factor, with an impressive increase of 60% compared to 2005. We now rank at 1,461, as shown in the statistics below. This is solely due to the increased quality of the published articles: In 2006, Astronomische Nachrichten -- Astronomical Notes published 208 research papers and received 1,033 citations -- five citations per paper on average. In 2007, we have published 177 research papers with roughly the same number of citations. In co-operation with Wiley InterScience we have achieved an average online publication time of just 4.5 months. We hope that the year 2008 will be comparably prosperous. As in the past, publication in Astronomische Nachrichten -- Astronomical Notes continues to be free of charge. Also, all articles of the first issue of each volume can be downloaded free of charge, as can all articles labelled ``Editor's Choice'', which are additionally featured with a color image on the front cover.

  5. Texture, Textuality and Political Discourse: A Study of Lexical Cohesion in Nigeria's President Goodluck Jonathan's Inaugural Address, May, 2011

    ERIC Educational Resources Information Center

    Enyi, Amaechi Uneke; Chitulu, Mark Ononiwu

    2015-01-01

    This study, entitled, "Texture and textuality in Political Discourse: A Study of Cohesive Devices in President Goodluck Jonathan's Inaugural Address-May, 2011" was an analysis of the lexical cohesive devices employed by Nigeria's President Goodluck Jonathan in crafting his May, 2011's Presidential Inaugural Address (PIA). Guided by the…

  6. STE - The Software Tools Editor

    NASA Astrophysics Data System (ADS)

    Software tools is an excellent book written by B. W. Kernighan and P. J. Plauger, published by Addison-Wesley. In it the authors discuss how to write programs that make good tools, and how to program well in the process. One of the tools they develop is a fairly powerful editor, written in Ratfor (a structured form of FORTRAN IV). This program has been implemented on the UCL Starlink VAX (with a few modifications and extensions) and is recommended as the editor to use on the VAX. This note gives a brief introduction to, and description of, the editor which has been abstracted from the book (which you are recommended to buy). There are some short command summary sections at the end of this note. After reading this note you may like to print these short files and use them for reference when using the editor.

  7. PREFACE: Scientific and Publishing Editors

    NASA Astrophysics Data System (ADS)

    2016-02-01

    1.Scientific Editors Section 1: Particle physics Mikhail Skorohvatov - NRC Kurchatov Institute, Moscow, Russia Section 2: Nuclear physics Mikhail Danilov - ITEP NRC Kurchatov Institute, Moscow, Russia Section 3: Cosmic rays Arkady Galper - NRNU MEPhI, Moscow, Russia Anatoly Petrukhin - NRNU MEPhI, Moscow, Russia Section 4: Methods of experimental physics Valery Dmitrenko - NRNU MEPhI, Moscow, Russia 2.Publishing Editors Irene Arkhangelskaja - NRNU MEPhI, Moscow, Russia Pavel Buzhan - NRNU MEPhI, Moscow, Russia

  8. Remarks from a retiring Editor

    NASA Astrophysics Data System (ADS)

    Mansur, Louis K.

    2015-10-01

    At the end of 2015 I plan to step down as Chairman of Editors for the Journal of Nuclear Materials. I use the opportunity to express thoughts that have recurred to me but were muted in comparison with the day to day priorities of editorial work. The most important is that I hold the deepest gratitude for your enduring support- authors, reviewers, readers, the Advisory Editorial Board, and my fellow Editors.

  9. Outcomes-based Education in South African Curricular Reform: A Response to Jonathan Jansen.

    ERIC Educational Resources Information Center

    Mason, Mark

    1999-01-01

    Responds to the article "Curriculum Reform in South Africa: A Critical Analysis of Outcomes-Based Education" by Jonathan Jansen. States that "Curriculum 2005" too strongly emphasizes procedural knowledge. Proposes a less radical version of outcomes-based education in which teachers integrate propositional, procedural, and…

  10. Political Identity and Moral Education: A Response to Jonathan Haidt's "The Righteous Mind"

    ERIC Educational Resources Information Center

    Blum, Lawrence

    2013-01-01

    In "The Righteous Mind," Jonathan Haidt claims that liberals have a narrower moral outlook than conservatives--they are concerned with fairness and relief of suffering, which Haidt sees as individualistic values, while conservatives care about authority and loyalty too, values concerned with holding society together. I question…

  11. The Scholarship of Jonathan Silin: A Reading through the Lens of Sexuality

    ERIC Educational Resources Information Center

    Grieshaber, Susan

    2013-01-01

    While Jonathan Silin's ideas have challenged early childhood educators to think seriously about the relationship between developmentalism and revisioning early education, they have done much more than this. They also challenge us to know who we are and how our identities might be enacted in our teacher-selves, whether in the classroom with young…

  12. The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith

    ERIC Educational Resources Information Center

    Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

    2014-01-01

    This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

  13. Loss, Failure, and an Awful Reputation: A Response to Jonathan Silin

    ERIC Educational Resources Information Center

    Britt, Clare

    2013-01-01

    In this article the author responds to Jonathan Silin's article "At a Loss: Scared and Excited", and in doing so, takes up his ideas around the generative potential of loss. She uses these notions of loss to illuminate how, in one diverse school community in Australia, loss, failure and an "awful reputation" have opened up…

  14. The Role of Education in Jewish Continuity: A Response to Jonathan Sacks

    ERIC Educational Resources Information Center

    Short, Geoffrey

    2005-01-01

    Contrasting explanations of Jewish survival form the backdrop to this article. For Jonathan Sacks (1994) the crucial factor has been the role played by Jewish education; indeed, he claims that the demographic threat currently facing Anglo-Jewry is largely the result of the community having neglected the Jewish education of its children over the…

  15. A Pragma-Stylistic Analysis of President Goodluck Ebele Jonathan Inaugural Speech

    ERIC Educational Resources Information Center

    Abuya, Eromosele John

    2012-01-01

    The study was an examination through the pragma-stylistic approach to meaning of the linguistic acts that manifest in the Inaugural Speech of Goodluck Ebele Jonathan as the democratically elected president in May 2011 General Elections in Nigeria. Hence, the study focused on speech acts type of locution, illocutionary and perlocutionary in the…

  16. Political Identity and Moral Education: A Response to Jonathan Haidt's "The Righteous Mind"

    ERIC Educational Resources Information Center

    Blum, Lawrence

    2013-01-01

    In "The Righteous Mind," Jonathan Haidt claims that liberals have a narrower moral outlook than conservatives--they are concerned with fairness and relief of suffering, which Haidt sees as individualistic values, while conservatives care about authority and loyalty too, values concerned with holding society together. I question…

  17. The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith

    ERIC Educational Resources Information Center

    Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

    2014-01-01

    This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

  18. 76 FR 58805 - Notice of Availability of Environmental Assessment; Jonathan and Jayne Chase

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... Energy Regulatory Commission Notice of Availability of Environmental Assessment; Jonathan and Jayne Chase In accordance with the National Environmental Policy Act of 1969 and the Federal Energy Regulatory... Environmental Assessment (EA). In the EA, Commission staff analyzed the potential environmental effects of the...

  19. Losing Oneself and Finding the Other: A Response to Jonathan Silin

    ERIC Educational Resources Information Center

    Bansel, Peter

    2013-01-01

    In responding to Jonathan Silin's article "At a Loss: Scared and Excited", the author takes up his invitation to articulate a relationship between the personal and the professional, and contemplates the autobiographical as more than a mode of recounting one's own experience. In so doing he foregrounds possibilities for working with an…

  20. Guest Editor's introduction

    NASA Astrophysics Data System (ADS)

    1996-03-01

    pleasure to be Guest Editor and I look forward to future developments in this growing research area and expositions in Distributed Systems Engineering. Peter G Harrison Imperial College, London

  1. GRL editors: 1986”1988

    NASA Astrophysics Data System (ADS)

    The leading rapid publication journal in the geophysical sciences is seeking candidates to succeed James C.G. Walker, whose term as editor-in-chief ends December 1985. AGU also seeks candidates to succeed the five regional editors: Rob Van der Voo, North America; Gaston J. Kockarts and William Lowrie, Europe; Tetsuya Sato, Asia; and Kurt Lambeck, Australia.AGU President Charles L. Drake has appointed a committee to recommend candidates for the 1986-1988 term. Resumes of those interested in serving in these influential and prestigious posts or letters of recommendation from those who wish to suggest candidates should be sent by February 15, 1985, to GRL Editor Search Committee, American Geophysical Union, 2000 Florida Ave., N.W., Washington, DC 20009.

  2. Message from the Editor

    NASA Astrophysics Data System (ADS)

    Stambaugh, Ronald D.

    2013-01-01

    reviewed five manuscripts in the period November 2011 to December 2012 and provided excellent advice to the authors. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in recent years. The following people have been selected: Marina Becoulet, CEA-Cadarache, France Jiaqui Dong, Southwestern Institute of Physics, China Emiliano Fable, Max-Planck-Institut für Plasmaphysik, Germany Ambrogio Fasoli, Ecole Polytechnique Federale de Lausanne, Switzerland Eric Fredrickson, Princeton Plasma Physics Laboratory, USA Manuel Garcia-Munoz, Max-Planck-Institut fuer Plasmaphysik, Germany William Heidbrink, California University, USA Katsumi Ida, National Inst. For Fusion Science, Japan Peter Stangeby, Toronto University, Canada James Strachan, Princeton Plasma Physics Laboratory, USA Victor Yavorskij, Ukraine National Academy of Sciences, Ukraine In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2012. Our thanks to them!

  3. ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy

    PubMed Central

    Baarine, Mauhamad; Beeson, Craig; Singh, Avtar; Singh, Inderjit

    2015-01-01

    X-linked Adrenoleukodystrophy (X-ALD), an inherited peroxisomal metabolic neurodegenerative disorder, is caused by mutations/deletions in the ABCD1 gene encoding peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). Metabolic dysfunction in X-ALD is characterized by the accumulation of very long chain fatty acids (VLCFAs; ≥ C22:0) in the tissues and plasma of patients. Here, we investigated the mitochondrial status following deletion of ABCD1 in B12 oligodendrocytes and U87 astrocytes. This study provides evidence that silencing of peroxisomal protein ABCD1 produces structural and functional perturbations in mitochondria. Activities of electron transport chain-related enzymes and of citric acid cycle (TCA cycle) were reduced; mitochondrial redox status was dysregulated and the mitochondrial membrane potential was disrupted following ABCD1 silencing. A greater reduction of ATP levels and citrate synthase activities was observed in oligodendrocytes as compared to astrocytes. Further, most of the mitochondrial perturbations induced by ABCD1 silencing were corrected by treating cells with SAHA (suberoylanilide hydroxamic acid), an HDAC inhibitor. These observations indicate a novel relationship between peroxisomes and mitochondria in cellular homeostasis and the importance of intact peroxisomes in relation to mitochondrial integrity and function in the cell types that participate in the pathobiology of X-ALD. These observations suggest SAHA as a potential therapy for X-ALD. PMID:25393703

  4. Quantification of SAHA-Dependent Changes in Histone Modifications Using Data-Independent Acquisition Mass Spectrometry

    PubMed Central

    Krautkramer, Kimberly A.; Reiter, Lukas; Denu, John M.; Dowell, James A.

    2015-01-01

    Histone post-translational modifications (PTMs) are important regulators of chromatin structure and gene expression. Quantitative analysis of histone PTMs by mass spectrometry remains extremely challenging due to the complex and combinatorial nature of histone PTMs. The most commonly used mass spectrometry-based method for high-throughput histone PTM analysis is data-dependent acquisition (DDA). However, stochastic precursor selection and dependence on MS1 ions for quantification impede comprehensive interrogation of histone PTM states using DDA methods. To overcome these limitations, we utilized a data-independent acquisition (DIA) workflow that provides superior run-to-run consistency and post-acquisition flexibility in comparison to DDA methods. In addition, we developed a novel DIA-based methodology to quantify isobaric, co-eluting histone peptides that lack unique MS2 transitions. Our method enabled deconvolution and quantification of histone PTMs that are otherwise refractory to quantitation, including the heavily acetylated tail of histone H4. Using this workflow, we investigated the effects of the histone deacetylase inhibitor SAHA (suberoylanilide hydroxamic acid) on the global histone PTM state of human breast cancer MCF7 cells. A total of 62 unique histone PTMs were quantified, revealing novel SAHA-induced changes in acetylation and methylation of histones H3 and H4. PMID:26120868

  5. Synergistic cytotoxicity of the DNA alkylating agent busulfan, nucleoside analogs and SAHA in lymphoma cell lines

    PubMed Central

    Valdez, Benigno C.; Murray, David; Nieto, Yago; Li, Yang; Wang, Guiyun; Champlin, Richard E.; Andersson, Borje S.

    2013-01-01

    Hematopoietic stem cell transplantation (HSCT) is a promising treatment for lymphomas. Its success depends on effective pre-transplant conditioning regimens. We previously reported on the efficacy of DNA alkylating agent-nucleoside analog (NA) combinations for conditioning in AML. We hypothesized that a similar combinatory approach can be used for lymphomas. A combination of busulfan (Bu) with two NAs – clofarabine (Clo), fludarabine (Flu) or gemcitabine (Gem) – resulted in synergistic cytotoxicity in lymphoma cell lines. We demonstrated that the [2 NAs+Bu] combination activates a DNA damage response through the ATM-CHK2 and ATM-CHK1 pathways, leading to cell cycle checkpoint activation and apoptosis. Histone modifications and KAP1 phosphorylation are indicative of chromatin relaxation mediated by the nucleoside analogs which sequentially increase Bu alkylation. Addition of suberoylanilide hydroxamic acid (SAHA) enhanced chromatin relaxation through increased histone acetylation and further augmented the cytotoxicity of [2 NAs+Bu]. Our results provide a preclinical basis for a clinical trial on using [2 NAs+Bu±SAHA] combinations as conditioning therapy for chemotherapy-refractory lymphoma patients undergoing HSCT. PMID:22023523

  6. Twin Rigid-Frames Hexapod Rovers for the Saha Radioastronomic Missions

    NASA Astrophysics Data System (ADS)

    Genta, G.

    One of the key issues of a radioastronomic and SETI mission in the Saha Crater is a data link which does not contribute to the radio pollution in the moon far side environment. The link must connect the radiotelescope, on the floor of the Saha crater to the radio station on Mare Smithii, 340 km away. If we wait for a permanent outpost to be established on the Moon, there will be little difficulty to lay out the system, but this would greatly delay the scientific return. Five different solutions, which can be implemented in the near future, are studied in the present paper: a tether connecting the two landers, a cable shot from the radiotelescope or deposited by a rover, three laser relay stations deposited by a rover and three laser stations, mounted on small rovers landed at prescribed positions. The last three alternatives can be implemented using walking rovers of the twin rigid-frames type. The paper studies in some detail the issue of designing the relevant rovers and performs a comparison of the various alternatives. As a result the landing of the laser relay stations in a suitable place located not too far from the optimal position for transmitting and receiving and then their precise positioning using walking rovers is found to be the simplest, cheapest and safest way to establish the data link

  7. Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo.

    PubMed

    Zhao, Yanxia; Yu, Dandan; Wu, Hongge; Liu, Hongli; Zhou, Hongxia; Gu, Runxia; Zhang, Ruiguang; Zhang, Sheng; Wu, Gang

    2014-02-01

    Suberoylanilide hydroxamic acid (SAHA), a potent pan-histone deacetylase (HDAC) inhibitor, has been clinically approved for the treatment of cutaneous T-cell lymphoma (CTCL). SAHA has also been shown to exert a variety of anticancer activities in many other types of tumors, however, few studies have been reported in large-cell lung carcinoma (LCC). Our study aimed to investigate the potential antitumor effects of SAHA on LCC cells. Here, we report that SAHA was able to inhibit the proliferation of the LCC cell line NCI-H460 in a dose- and time-dependent manner, induced cell apoptosis and G2/M cell cycle arrest, decreased AKT and ERK phosphorylation, inhibited the expression of pro-angiogenic factors (VEGF, HIF-1α) in vitro, and suppressed tumor progression in an NCI-H460 cell nude mouse xenograft model in vivo. These results indicate that SAHA can exert its strong antitumor effects in LCC patient.

  8. Research Review: Magazine Editors and Editing Practices.

    ERIC Educational Resources Information Center

    Jolliffe, Lee

    1994-01-01

    Reviews and critiques literature in the subfield of magazine editing research, chiefly biographical studies of individual editors and various types of studies of editorial practices, including surveys, magazine content analyses, and close qualitative examinations of editors' relationships with others. (SR)

  9. Research Review: Magazine Editors and Editing Practices.

    ERIC Educational Resources Information Center

    Jolliffe, Lee

    1994-01-01

    Reviews and critiques literature in the subfield of magazine editing research, chiefly biographical studies of individual editors and various types of studies of editorial practices, including surveys, magazine content analyses, and close qualitative examinations of editors' relationships with others. (SR)

  10. SIERRA Editor v. 1.2.1

    SciTech Connect

    Hoffman, Edward; Friedman-Hill, Ernest; Gibson, Marcus; Heinstein, Martin; & Whittford, Greg

    2010-03-24

    The SIERRA Editor is a syntax editor for text-based input decks for the SIERRA modeling and simulations codes. The SIERRA Editor provides color coded syntax, error checking, hyperlink navigation to referenced entities (e.g. functions and materials), and visual verification of mesh entity references (blocks, sidesets, and nodesets). The SIERRA Editor helps modeling and simulation analysts who use the SIERRA codes to produce syntactically correct input decks.

  11. In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC)

    PubMed Central

    2011-01-01

    Background The cervical cancer is the second most prevalent cancer for the woman in the world. It is caused by the oncogenic human papilloma virus (HPV). The inhibition activity of histone deacetylase (HDAC) is a potential strategy for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is widely known as a low toxicity HDAC inhibitor. This research presents in silico SAHA modification by utilizing triazole, in order to obtain a better inhibitor. We conducted docking of the SAHA inhibitor and 12 modified versions to six class II HDAC enzymes, and then proceeded with drug scanning of each one of them. Results The docking results show that the 12 modified inhibitors have much better binding affinity and inhibition potential than SAHA. Based on drug scan analysis, six of the modified inhibitors have robust pharmacological attributes, as revealed by drug likeness, drug score, oral bioavailability, and toxicity levels. Conclusions The binding affinity, free energy and drug scan screening of the best inhibitors have shown that 1c and 2c modified inhibitors are the best ones to inhibit class II HDAC. PMID:22373132

  12. Simultaneous determination of decitabine and vorinostat (Suberoylanalide hydroxamic acid, SAHA) by liquid chromatography tandem mass spectrometry for clinical studies.

    PubMed

    Patel, Katan; Guichard, Sylvie M; Jodrell, Duncan I

    2008-02-15

    A reverse-phase high-performance liquid chromatography method with electrospray ionization and detection by tandem mass spectrometry is described for the simultaneous quantitative determination of decitabine (5-aza-2'-deoxycytidine) and vorinostat (Suberoylanalide hydroxamic acid, SAHA) in human plasma. The method involves a simple acetonitrile precipitation step and centrifugation followed by injection of the supernatant onto a C18 150mmx2.1mm I.D., 3microm HPLC column at 36 degrees C. Separation of decitabine, SAHA and their respective internal standards was achieved with a gradient elution and detection was via the mass spectrometer operated in selected reaction monitoring mode. The method was within the defined validation parameters for linearity, repeatability, reproducibility and stability. The limit of detection was determined as 1.0 and 0.125ngml(-1) and lower limits of quantitation were 10 and 1ngml(-1) for decitabine and SAHA, respectively. Effects of sample preparation on stability were also evaluated in human plasma. For clinical sample handling tetrahydrouridine, an inhibitor of cytidine deaminase was found to help prevent decitabine degradation. The method is currently being used in clinical pharmacokinetic studies for the evaluation of decitabine and SAHA combination therapies.

  13. In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC).

    PubMed

    Tambunan, Usman S F; Bramantya, N; Parikesit, Arli A

    2011-01-01

    The cervical cancer is the second most prevalent cancer for the woman in the world. It is caused by the oncogenic human papilloma virus (HPV). The inhibition activity of histone deacetylase (HDAC) is a potential strategy for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is widely known as a low toxicity HDAC inhibitor. This research presents in silico SAHA modification by utilizing triazole, in order to obtain a better inhibitor. We conducted docking of the SAHA inhibitor and 12 modified versions to six class II HDAC enzymes, and then proceeded with drug scanning of each one of them. The docking results show that the 12 modified inhibitors have much better binding affinity and inhibition potential than SAHA. Based on drug scan analysis, six of the modified inhibitors have robust pharmacological attributes, as revealed by drug likeness, drug score, oral bioavailability, and toxicity levels. The binding affinity, free energy and drug scan screening of the best inhibitors have shown that 1c and 2c modified inhibitors are the best ones to inhibit class II HDAC.

  14. Learning To Use a Text Editor.

    ERIC Educational Resources Information Center

    Beal, Carole R.; Griffin, Elizabeth A.

    Designed to determine how quickly elementary school children can learn to use a text editor and what editing concepts are difficult for them to master, this study presents preliminary data on children's acquisition of text editor skills and on the kinds of revisions they accomplished with the text editor. Observations were made on a total of 25…

  15. Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2012-04-01

    Whilst travelling to Vienna to hand over the Editorship of Nuclear Fusion to Ron Stambaugh, I jotted down a few ideas to put in a farewell message. Somewhat unsurprisingly, I find them almost identical to the remarks that Chris Schueller made in handing over to me five years ago. Both of us served in this role for five years, which seems like a good timescale to replace presidents and editors alike; just to allow a fresh approach. In addition, since I have been directly involved in ITER, I have found it increasingly difficult, due to time pressure, to give the journal the attention that it deserves. Therefore, I am very pleased that Ron Stambaugh has agreed to take over as Editor. Not only does he bring the experience as a leading figure in the US fusion programme but, in addition, he has all the contacts, worldwide, from his leadership of the ITPA. I am completely assured that the journal is in a highly competent pair of hands. Such a farewell should not lack my heartfelt thanks to all of those who have made being Editor of Nuclear Fusion so enjoyable and stimulating; readership, authors, referees, the Editorial Board and the NF Office alike. I wish Ron all the best for his tenure and have offered such help and support as I am able to give.

  16. Setup for potential bias experiments on the Saha Institute of Nuclear Physics tokamak

    NASA Astrophysics Data System (ADS)

    Ghosh, J.; Pal, R.; Chattopadhyay, P. K.

    1999-12-01

    An experimental setup for studying the influence of the radial electric field on very low qa plasma on the Saha Institute of Nuclear Physics tokamak is presented. A high current, high voltage pulsed power supply, using a semiconductor controlled rectifier (SCR) as a dc switch is developed and used to bias a tungsten electrode inserted inside the plasma. The electrode's exposed length and its position inside the plasma are controlled by a double bellows assembly to optimize the electrode-exposed length. We show that using the force commutation method to turn the SCR off to get the power pulse desired has good potential for carrying out similar kinds of studies, especially in a low budget small tokamak.

  17. Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays.

    PubMed

    Barazzuol, Lara; Jeynes, J Charles G; Merchant, Michael J; Wéra, Anne-Catherine; Barry, Miriam A; Kirkby, Karen J; Suzuki, Masao

    2015-01-01

    Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we used a combination of two novel treatment modalities: Carbon ions and a histone deacetylase inhibitor (HDACi). We compared these to conventional X-rays, measuring the increased effectiveness of carbon ions as well as radiosensitization using HDACi. Suberoylanilide hydroxamic acid (SAHA) was used at a non-toxic concentration of 0.5 μM in combination with 85 keV μm(-1) carbon ions, and 250 kVp X-rays for comparison. Effects were assayed using clonogenic survival, γH2AX foci repair kinetics and measuring chromatin decondensation. Dose toxicity curves showed that human GBM LN18 cells were more sensitive to SAHA compared to U251 cells at higher doses, but there was little effect at low doses. When combined with radiation, clonogenic assays showed that the Sensitizer Enhancement Ratio with carbon ions at 50% survival (SER(50)) was about 1.2 and 1.5 for LN18 and U251, respectively, but was similar for X-rays at about 1.3. The repair half-life of γH2AX foci was slower for cells treated with SAHA and was most noticeable in U251 cells treated with carbon ions where after 24 h, more than double the number of foci remained in comparison to the untreated cells. Hoechst fluorescent dye incorporation into the nucleus showed significant chromatin decondensation and density homogenization with SAHA treatment for both cell lines. Our results suggest a vital role of histone deacetylases (HDAC) in the modulation of DNA damage response and support the use of SAHA for the treatment of GBM through the combination with heavy ion therapy.

  18. ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy.

    PubMed

    Baarine, Mauhamad; Beeson, Craig; Singh, Avtar; Singh, Inderjit

    2015-05-01

    X-linked Adrenoleukodystrophy (X-ALD), an inherited peroxisomal metabolic neurodegenerative disorder, is caused by mutations/deletions in the ATP-binding cassette transporter (ABCD1) gene encoding peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). Metabolic dysfunction in X-ALD is characterized by the accumulation of very long chain fatty acids ≥ C22:0) in the tissues and plasma of patients. Here, we investigated the mitochondrial status following deletion of ABCD1 in B12 oligodendrocytes and U87 astrocytes. This study provides evidence that silencing of peroxisomal protein ABCD1 produces structural and functional perturbations in mitochondria. Activities of electron transport chain-related enzymes and of citric acid cycle (TCA cycle) were reduced; mitochondrial redox status was dysregulated and the mitochondrial membrane potential was disrupted following ABCD1 silencing. A greater reduction in ATP levels and citrate synthase activities was observed in oligodendrocytes as compared to astrocytes. Furthermore, most of the mitochondrial perturbations induced by ABCD1 silencing were corrected by treating cells with suberoylanilide hydroxamic acid, an Histone deacetylase inhibitor. These observations indicate a novel relationship between peroxisomes and mitochondria in cellular homeostasis and the importance of intact peroxisomes in relation to mitochondrial integrity and function in the cell types that participate in the pathobiology of X-ALD. These observations suggest suberoylanilide hydroxamic acid as a potential therapy for X-ALD. Schematic description of the effects of loss of peroxisomal ATP-binding cassette transporter D1 (ABCD1) gene on cellular Redox and mitochondrial activities and their correction by suberoylanilide hydroxamic acid (SAHA) treatment. Pathogenomic accumulation of very long chain fatty acids (VLCFA) as a result of loss of ABCD1 leads to dysfunctions of mitochondrial biogenesis and its activities. Treatment with SAHA corrects

  19. SAHA down-regulates the expression of indoleamine 2,3-dioxygenase via inhibition of the JAK/STAT1 signaling pathway in gallbladder carcinoma cells.

    PubMed

    Zhang, Peng; Jiang, Guanmin; Gao, Jiao; Li, Lingling; Du, Jun; Jiao, Xingyuan

    2013-01-01

    The aim of the present study was to investigate the role of the JAK/STAT1 signaling pathway in suberoylanilide hydroxamic acid (SAHA)-mediated down-regulation of indoleamine 2,3-dioxygenase (IDO) in gallbladder carcinoma cells. We treated SGC-996 gallbladder carcinoma cells with IFN-γ and SAHA. Western blotting was used to detect the expression of IDO, signal transducer and activator of transcription 1 (STAT1) phosphorylation and interferon regulatory factor genes-1 (IRF-1). Confocal microscopy analysis was used to detect STAT1 translocation. Transient transfection and reporter gene assay was used for detecting the activation of γ-activated sites (GAS) and interferon-stimulated response elements (ISRE). The results revealed that IDO was expressed in SGC-996 cells in a dose- and time-dependent manner when stimulated with IFN-γ and SAHA down-regulated the expression of IDO induced by IFN-γ in a dose-dependent manner. SAHA blocked the expression of IRF-1 induced by IFN-γ and SAHA inhibited IFN-γ-induced STAT1 phosphorylation and nuclear translocation. In addition, SAHA down-regulated IFN-γ-induced activation of GAS and ISRE. In conclusion, SAHA down-regulated IDO expression via inhibition of the activation of members of the JAK/STAT1 signaling pathway. Therefore, regulation of the JAK/STAT1 signaling pathway may provide a new gallbladder carcinoma immunotherapeutic strategy to break tumor immune tolerance.

  20. Molecular dynamics simulation of complex Histones Deacetylase (HDAC) Class II Homo Sapiens with suberoylanilide hydroxamic acid (SAHA) and its derivatives as inhibitors of cervical cancer.

    PubMed

    Tambunan, Usman Sumo Friend; Bakri, Ridla; Prasetia, Tirtana; Parikesit, Arli Aditya; Kerami, Djati

    2013-01-01

    Cervical cancer is second most common cancer in woman worldwide. Cervical cancer caused by human papillomavirus (HPV) oncogene. Inhibition of histone deacetylase (HDAC) activity has been known as a potential strategy for cancer therapy. SAHA is an HDAC inhibitor that has been used in cancer therapy but still has side effects. SAHA modification proposed to minimize side effects. Triazole attachment on the chain of SAHA has been known to enhance the inhibition ability of SAHA and less toxic. In this study, it will be carried out with molecular dynamic simulations of SAHA modifications consisting ligand 1a, 2a and, 2c to interact with six HDAC in hydrated conditions. To all six HDAC Class II, performed docking with SAHA and a modified inhibitor. The docking results were then carried out molecular dynamics simulations to determine the inhibitor affinities in hydrated conditions. The molecular dynamic simulations results show better affinities of ligand 2c with HDAC 4, 6, and 7 than SAHA itself, and good affinity was also shown by ligand 2a and 1c on HDAC 5 and 9. The results of this study can be a reference to obtain better inhibitors.

  1. Line-Editor Computer Program

    NASA Technical Reports Server (NTRS)

    Scott, Peter J.

    1989-01-01

    ZED editing program for DEC VAX computer simple, powerful line editor for text, program source code, and nonbinary data. Excels in processing of text by use of procedure files. Also features versatile search qualifiers, global changes, conditionals, online help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. Users of Cambridge implementation devised such ZED procedures as chess games, calculators, and programs for evaluating pi. Written entirely in C.

  2. Line-Editor Computer Program

    NASA Technical Reports Server (NTRS)

    Scott, Peter J.

    1989-01-01

    ZED editing program for DEC VAX computer simple, powerful line editor for text, program source code, and nonbinary data. Excels in processing of text by use of procedure files. Also features versatile search qualifiers, global changes, conditionals, online help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. Users of Cambridge implementation devised such ZED procedures as chess games, calculators, and programs for evaluating pi. Written entirely in C.

  3. A Syntax Directed Editor Environment.

    DTIC Science & Technology

    1983-12-05

    Much of his work was based on research by Bruce J. MacLennan of the Naval Postgraduate School (Ref 9) and two of Mister MacLennan’s former thesis...of Defense. Requirement for ADA Programming Suport | .:Environments - Stoneman. Washington, D.C. 1980. • .,6. Feiler , Peter H. and Raul Medina-Mora...1982. (AD-A053032). 9. MacLennan, Bruce J. The Automatic Generation of Syntax-Directed Editors. Naval Postgraduate School, Monterey, CA., 1981. 10

  4. EDITORIAL: Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2010-02-01

    November 2009 and provided particularly detailed advice to the authors. The other three have been very helpful in 'minority fields'. We have excluded our Board members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their Special Issues is also excluded from consideration. The following people have been selected: Tomonori Takizuka, JAEA-Naka Fusion Institute, Japan Rudolf Neu, Max-Planck-Institut für Plasmaphysik, Germany Sibylle Guenter, Max-Planck-Institut für Plasmaphysik, Germany Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States David R. Mikkelsen, Princeton Plasma Physics Laboratory, United States Peter C. de Vries, EURATOM/UKAEA Fusion Association, United Kingdom Yasuhiro Suzuki, National Institute for Fusion Science, Japan Jerzy Wolowski, Institute of Plasma Physics and Laser Microfusion, Poland Tetsuo Tanabe, Kyushu University, Japan Yasuyuki Yagi, National Institute of Advanced Industrial Science and Technology, Japan Congratulations and many, many thanks! The Guest Editors of special editions deserve a special mention for the excellent help that they have given us. They are: Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States, Special Issue on H-Mode Physics and Transport Barriers Yaroslav Kolesnichenko, Institute for Nuclear Research, Ukraine, Special Issue on Energetic Particles in Magnetic Confinement Systems Kimitaka Itoh, National Institute for Fusion Science, Japan and Howard R. Wilson, University of York, UK, Special Issue on Plasma Instabilities Bernhard Unterberg, Forschungszentrum Juelich, Germany, Special Issue on Stochastic Fusion Plasma In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2009. Our thanks to them! Authors The winner of the 2009 Nuclear Fusion

  5. Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation.

    PubMed

    Hu, Qing-Peng; Mao, Ding-An

    2016-05-18

    Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SAHA is a histone deacetylase inhibitor that regulates gene expression by increasing chromatin histone acetylation. In this study, we investigated the role of SAHA in TLR4/MYD88 signaling in a rat seizure model. Sprague-Dawley rats with kainic acid (KA)-induced seizures were treated with SAHA. The expression of TLR4, MYD88, NF-κB P65 and IL-1β in hippocampus was detected at hour 2 and 6 and day 1, 2, and 3 post seizure. SAHA pretreatment increased seizure latency and decreased seizure scores. The expression levels of TLR4, MYD88, NF-κB and IL-1β increased significantly in both activated microglia and apoptotic neurons after KA treatment. The effects were attenuated by SAHA. Chromatin immunoprecipitation assays indicated that the H3 histone acetylation levels significantly decreased while H3K9 levels significantly increased in the KA treatment group. The H3 and H3K9 acetylation levels returned to control levels after SAHA (50 mg/kg) pretreatment. There was a positive correlation between the expression of TLR4 and the acetylation levels of H3K9. Histone deacetylase inhibitor SAHA can suppress seizure-induced TLR4/MYD88 signaling and inhibit TLR4 gene expression through histone acetylation regulation. This suggests that SAHA may protect against seizure-induced brain damage.

  6. Donald R. Nielsen New WRR Editor

    NASA Astrophysics Data System (ADS)

    Robb, David W.

    Bridging the gap between the disciplines of engineering and agriculture is a major goal for Water Resources Research (WRR), says Donald R. Nielsen, who was appointed to a 4-year term as WRR editor, effective January 1, 1985. Nielsen succeeds Stephen J. Burges as the WRR editor for hydrology, physical, chemical, and biological sciences. Ronald G. Cummings, at the University of New Mexico, is the WRR editor for policy sciences, including economics, systems analysis, sociology, and law.

  7. Increased expression of histone deacetylaces (HDACs) and inhibition of prostate cancer growth and invasion by HDAC inhibitor SAHA

    PubMed Central

    Wang, Longgui; Zou, Xuanyi; Berger, Aaron D.; Twiss, Christian; Peng, Yi; Li, Yirong; Chiu, Jason; Guo, Hongfeng; Satagopan, Jaya; Wilton, Andrew; Gerald, William; Basch, Ross; Wang, Zhengxin; Osman, Iman; Lee, Peng

    2009-01-01

    Histone deacetetylases (HDACs) are a group of corepressors of transcriptional activators and their levels of expression are potentially dysregulated in prostate cancer. Certain inhibitors of histone deacetylases show anti-tumor activity in prostate cancer cell lines. Here, we systemically studied the expression of HDACs in human prostate cancer and the suppression of prostate cancer growth and invasion by HDAC inhibitor SAHA. HDAC1-5 showed increased expression using a combination of DNA microarray, in-situ hybridization, and immunohistochemistry in benign and malignant human prostate tissue as well as RT-PCR and Western blot analysis on various PCa cell lines. Importantly, HDAC inhibitor SAHA suppressed, in particular, prostate cancer cell growth and invasion determined using cell proliferation and Matrigel invasion assays. The findings of this study show that the expression of HDACs and their associated corepressors are increased in prostate cancer in humans and HDAC inhibitor SAHA could serve as a potential therapeutic agent in prostate cancer in addition to anti-androgens. PMID:19966939

  8. EDITORIAL: Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2011-01-01

    As usual, being an even year, the 23rd IAEA Fusion Energy Conference took place at Daejeon, Korea. The event was notable not just for the quality of the presentations but also for the spectacular opening ceremony, in the presence of the Prime Minister, Kim Hwang-sik. The Prime Minister affirmed the importance of research into fusion energy research and pledged support for ITER. Such political visibility is good news, of course, but it brings with it the obligation to perform. Fortunately, good performance was much in evidence in the papers presented at the conference, of which a significant proportion contain 'ITER' in the title. Given this importance of ITER and the undertaking by the Nuclear Fusion journal to publish papers associated with Fusion Energy Conference presentations, the Nuclear Fusion Editorial Board has decided to adopt a simplified journal scope that encompasses technology papers more naturally. The scope is available from http://iopscience.iop.org/0029-5515/page/Journal%20information but is reproduced here for clarity: Nuclear Fusion publishes articles making significant advances to the field of controlled thermonuclear fusion. The journal scope includes: the production, heating and confinement of high temperature plasmas; the physical properties of such plasmas; the experimental or theoretical methods of exploring or explaining them; fusion reactor physics; reactor concepts; fusion technologies. The key to scope acceptability is now '....significant advances....' rather than any particular area of controlled thermonuclear fusion research. It is hoped that this will make scope decisions easier for the Nuclear Fusion office, the referees and the Editor.The Nuclear Fusion journal has continued to make an important contribution to the research programme and has maintained its position as the leading journal in the field. This is underlined by the fact that Nuclear Fusion has received an impact factor of 4.270, as listed in ISI's 2009 Science Citation

  9. Stars, Peripheral Scientists, and Equations: The Case of M. N. Saha

    NASA Astrophysics Data System (ADS)

    Dasgupta, Deepanwita

    2015-06-01

    Peripheral actors rarely make an appearance in the general story of scientific practice, and their work in science is usually viewed as somewhat derivative of the practices of the main community. Contrary to this received model, here I argue that the peripheral contexts of science can be quite important and reveal novel conduits to creative scientific thinking. Not only can such contexts offer us a new window into how contributory expertise in science could be born amid difficult circumstances, they also allow us to see how new scientific communities could be founded during such encounters. Using case studies of M. N. Saha and other physicists in early twentieth-century India, I argue that such modest practices begin when peripheral protagonists seek to initiate new trading zones with the established centers of science. The resulting exchanges can give rise to new breakthroughs and conceptual changes in scientific practice. Such peripheral breakthroughs can be studied cognitively, giving us newer models of scientific practice as well as creating a new kind of self-image for such scientists.

  10. Laser-induced plasma electron number density: Stark broadening method versus the Saha-Boltzmann equation

    NASA Astrophysics Data System (ADS)

    Arnab, Sarkar; Manjeet, Singh

    2017-02-01

    We report spectroscopic studies on plasma electron number density of laser-induced plasma produced by ns-Nd:YAG laser light pulses on an aluminum sample in air at atmospheric pressure. The effect of different laser energy and the effect of different laser wavelengths were compared. The experimentally observed line profiles of neutral aluminum have been used to extract the excitation temperature using the Boltzmann plot method, whereas the electron number density has been determined from the Stark broadened as well as using the Saha-Boltzmann equation (SBE). Each approach was also carried out by using the Al emission line and Mg emission lines. It was observed that the SBE method generated a little higher electron number density value than the Stark broadening method, but within the experimental uncertainty range. Comparisons of N e determined by the two methods show the presence of a linear relation which is independent of laser energy or laser wavelength. These results show the applicability of the SBE method for N e determination, especially when the system does not have any pure emission lines whose electron impact factor is known. Also use of Mg lines gives superior results than Al lines.

  11. On incorporating fire into our thinking about natural ecosystems: A response to Saha and Howe

    USGS Publications Warehouse

    Keeley, Jon E.; Bond, William J.

    2001-01-01

    Ecologists long have had a fascination with fire impacts, although they have been slow to incorporate this ecological factor into serious thinking about the structure of communities and evolution of species (Bond and van Wilgen 1996).  The remarks by Saha and Howe (2001, in this issue) illustrate some of the problems ecologists have in trying to apply fire to their thinking about natural ecosystems.  Fire is commonly perceived qualitatively in terms of presence or absence, and the variation in frequency and intensity, as well as other components of the fire regime (e.g., fig. 1), is ignored.  Often not considered is the fact that plant life histories are fine-tuned to particular fire regims, and in this regard, landscapes present a range of selective peaks and valleys, both figuratively and literally.  Because landscape patterns affect the propagation of natural fires, it is imperative that the degree of human disturbance be considered (e.g. Marsh [1864] 1965; Gadgil and Guhu 1993) and the limitations of basing evolutionary arguments on anthropogenically derived landscapes be recognized (e.g., Janzen and Martin 1982).

  12. Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

    ERIC Educational Resources Information Center

    Amare, Nicole; Manning, Alan

    2009-01-01

    Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

  13. Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

    ERIC Educational Resources Information Center

    Amare, Nicole; Manning, Alan

    2009-01-01

    Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

  14. PROGRAMMABLE DISPLAY PUSHBUTTON LEGEND EDITOR

    NASA Technical Reports Server (NTRS)

    Busquets, A. M.

    1994-01-01

    The Programmable Display Pushbutton (PDP) is a pushbutton device available from Micro Switch which has a programmable 16 x 35 matrix of LEDs on the pushbutton surface. Any desired legends can be displayed on the PDPs, producing user-friendly applications which greatly reduce the need for dedicated manual controls. Because the PDP can interact with the operator, it can call for the correct response before transmitting its next message. It is both a simple manual control and a sophisticated programmable link between the operator and the host system. The Programmable Display Pushbutton Legend Editor, PDPE, is used to create the LED displays for the pushbuttons. PDPE encodes PDP control commands and legend data into message byte strings sent to a Logic Refresh and Control Unit (LRCU). The LRCU serves as the driver for a set of four PDPs. The legend editor (PDPE) transmits to the LRCU user specified commands that control what is displayed on the LED face of the individual pushbuttons. Upon receiving a command, the LRCU transmits an acknowledgement that the message was received and executed successfully. The user then observes the effect of the command on the PDP displays and decides whether or not to send the byte code of the message to a data file so that it may be called by an applications program. The PDPE program is written in FORTRAN for interactive execution. It was developed on a DEC VAX 11/780 under VMS. It has a central memory requirement of approximately 12800 bytes. It requires four Micro Switch PDPs and two RS-232 VAX 11/780 terminal ports. The PDPE program was developed in 1985.

  15. [Report of the editors, 2011].

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2012-01-01

    The editors of Revista Clínica Española (Rev Clin Esp) inform on their editorial activity during the last 12 months (November 2010 to October 2011): (a) Objectives and attainments during 2011, (b) editorial activity, and (c) objectives for 2012. In 2011 we have updated the editorial algorithm (revision by the responsible editor of all manuscripts sent to peer review and incorporated an «editorial coordinator»), we have renovated two advise facilities (editorial and scientific committees), we have created a new section called «monthly e-image», and we have promoted Rev Clin Esp annual prizes. From the first January 2010 to 31(st) October 2011 we handled 422 manuscripts (42,2 manuscripts per month, higher than the 2010 figure of 40,4 manuscript/month). Overall we have accepted 26% (originals, 16%). We asked for 343 revisions and obtained 231 (67%). Seventy two percent of the reviewers sent their comments in less than two weeks. The mean time taken to accept or reject a given manuscript has been 26 days. The mean time taken since a manuscript is received to publication (october, novembrer and december issues) has dropped from 334 days in 2010 to 254 in 2011 (24% decrease). The collaboration with the working groups has reported about 2 published manuscripts per issue. Our objectives for 2012 are: (a) to improve the editorial process; (b) main article translation into English; (c) improve some sections (i.e. clinical conference); (d) estimulate working groups collaboration; and (e) improve continued medical education. Revista Clínica Española is an open forum for all internal medicine specialists. We all have the responsibility to make our journal, each day, better.

  16. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.

    PubMed

    White, Cory H; Johnston, Harvey E; Moesker, Bastiaan; Manousopoulou, Antigoni; Margolis, David M; Richman, Douglas D; Spina, Celsa A; Garbis, Spiros D; Woelk, Christopher H; Beliakova-Bethell, Nadejda

    2015-11-01

    Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a "shock and kill" strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA ("shock"), treatment with SAHA did not result in a reduction of reservoir size ("kill"). We therefore utilized a combined analysis of effects of SAHA on the host transcriptome and proteome to dissect its mechanisms of action that may explain its limited success in "shock and kill" strategies. CD4+ T cells from HIV seronegative donors were treated with 1μM SAHA or its solvent dimethyl sulfoxide (DMSO) for 24h. Protein expression and post-translational modifications were measured with iTRAQ proteomics using ultra high-precision two-dimensional liquid chromatography-tandem mass spectrometry. Gene expression was assessed by Illumina microarrays. Using limma package in the R computing environment, we identified 185 proteins, 18 phosphorylated forms, 4 acetylated forms and 2982 genes, whose expression was modulated by SAHA. A protein interaction network integrating these 4 data types identified the HIV transcriptional repressor HMGA1 to be upregulated by SAHA at the transcript, protein and acetylated protein levels. Further functional category assessment of proteins and genes modulated by SAHA identified gene ontology terms related to NFκB signaling, protein folding and autophagy, which are all relevant to HIV reactivation. In summary, SAHA modulated numerous host cell transcripts, proteins and post-translational modifications of proteins, which would be expected to have very mixed effects on the induction of HIV-specific transcription and protein function. Proteome profiling highlighted a number of potential counter-regulatory effects of SAHA with respect to viral induction, which transcriptome profiling alone would not have identified. These observations could lead to a more informed selection and design of other HDACi with a more refined targeting profile, and

  17. Antitumor activity of SAHA, a novel histone deacetylase inhibitor, against murine B cell lymphoma A20 cells in vitro and in vivo.

    PubMed

    Yang, Bohan; Yu, Dandan; Liu, Jingwen; Yang, Kunyu; Wu, Gang; Liu, Hongli

    2015-07-01

    Suberoylanilide hydroxamic acid (SAHA; vorinostat), the second generation of histone deacetylase (HDAC) inhibitor, has been approved for the treatment of cutaneous manifestations of cutaneous T cell lymphoma (CTCL). It has also shown its anticancer activity over a large range of other hematological and solid malignancies, but few studies have been reported in B cell lymphoma. In this study, we aimed to investigate the antitumor activity of SAHA on murine B cell lymphoma cell line A20 cells. We treated A20 cells with different concentrations of SAHA. The effect of SAHA on the proliferation of A20 cells was studied by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium (MTT) assay in vitro; the anti-proliferation activity in vivo was evaluated by proliferating cell nuclear antigen (PCNA) of xenograft tumor tissues through immunocytochemical staining. Apoptosis were detected by Hoechst 33258 staining and Annexin V/propidium iodide (PI) double-labeled cytometry in vitro. The effect of SAHA on cell cycle of A20 cells was studied by a propidium iodide method. Autophagic cell death induced by SAHA was confirmed by transmission electron microscopy (TEM). Angiogenesis marker (CD31) was measured by immunocytochemical staining to investigate the anti-angiogenic effect of SAHA. Western blot was used to detect the expression of signaling pathway factors (phospho-AKT, phospho-ERK, AKT, ERK, Nur77, HIF-1α, and VEGF). Our results showed that SAHA inhibited the proliferation of A20 cells in a time- and dose-dependent manner, induced cell apoptosis and G0/G1 phase arrest of cell cycle, promoted autophagic cell death, and suppressed tumor progress in NCI-A20 cells nude mice xenograft model in vivo. SAHA decreased the activation of AKT (phospho-AKT: p-AKT) and ERK1/2 (phospho-ERK: p-ERK) proteins and inhibited the expression of pro-angiogenic factors (VEGF and HIF-1α), downregulated its downstream signaling factor (Nur77), which might be contributed to the antitumor mechanisms

  18. EDITORIAL: Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2009-01-01

    Plasmaphysik, Germany) V. Philipps (Forschungszentrum Juelich, Germany) S. Zweben (Princeton Plasma Physics Laboratory, USA) Y. Hirano (National Institute of Advanced Industrial Science and Technology, Japan) Y. Takase (Tokyo University, Japan) In addition there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2008. Our thanks to them! Authors The winner of the 2007 award was Clemente Angioni for the paper entitled `Density response to central electron heating: theoretical investigations and experimental observations in ASDEX Upgrade' (Nucl. Fusion 44 8277-845). The winner of the 2008 Nuclear Fusion award is Todd Evans et al for the paper `Suppression of large edge localized modes with edge resonant magnetic fields in high confinement DIII-D plasmas' (Nucl. Fusion 45 595-607). The awards were presented by the IAEA Deputy Director General, Werner Burkart, and the Chairman of the Board of Editors, Mitsuru Kikuchi, on 16 October 2008 at the 22nd IAEA Fusion Energy Conference in Geneva, Switzerland. Given the topicality of these papers for the ITER design, it is a matter of pride to the journal that the work should be published in Nuclear Fusion. Reviews Like many who have worked for a long time in the field, I still make use of Nuclear Fusion Reviews that go back 20 or 30 years. It is particularly useful, therefore, that the Board of Editors has been working to re-activate the review programme. The first fruits will appear in this issue, in the form of `A review of zonal flow experiments', by Akihide Fujisawa. The special procedures for Reviews should be noted: most specifically that they should normally be commissioned by the Board of Editors. However, not only is the Board of Editors working on a programme but I am sure that they would be pleased to consider suggestions for review subjects. Letters The reputation of Nuclear

  19. Linguistic Prescriptivism in Letters to the Editor

    ERIC Educational Resources Information Center

    Lukac, Morana

    2016-01-01

    The public's concern with the fate of the standard language has been well documented in the history of the complaint tradition. The print media have for centuries featured letters to the editor on questions of language use. This study examines a corpus of 258 language-related letters to the editor published in the English-speaking print media. By…

  20. Editorial Commentary: Editor's Conflict of Interest.

    PubMed

    Lubowitz, James H

    2015-09-01

    The Editor-in-chief has recused himself from industry consulting, which he performed before assuming the position, and returned related royalties and divested related stock options, in order to mitigate against conflict-of-interest. The Editor discloses affiliation with an institution that receives support from diverse industry partners in support of research and education.

  1. Linguistic Prescriptivism in Letters to the Editor

    ERIC Educational Resources Information Center

    Lukac, Morana

    2016-01-01

    The public's concern with the fate of the standard language has been well documented in the history of the complaint tradition. The print media have for centuries featured letters to the editor on questions of language use. This study examines a corpus of 258 language-related letters to the editor published in the English-speaking print media. By…

  2. An Idea Book for the Education Editor.

    ERIC Educational Resources Information Center

    Brodinsky, Ben, Ed.

    To be used as a reference and guide for education editors, this booklet contains advice and information on writing, editing, production, publishing, the magazine, and the newsletter. The final section discusses the role and duties of the education editor. This edition contains material from the 1963 brochure of the same name, new material selected…

  3. The MaPLE device of Saha Institute of Nuclear Physics: Construction and its plasma aspects

    SciTech Connect

    Pal, Rabindranath; Biswas, Subir; Basu, Subhasis; Chattopadhyay, Monobir; Basu, Debjyoti; Chaudhuri, Manis

    2010-07-15

    The Magnetized Plasma Linear Experimental (MaPLE) device is a low cost laboratory plasma device at Saha Institute of Nuclear Physics fabricated in-house with the primary aim of studying basic plasma physics phenomena such as plasma instabilities, wave propagation, and their nonlinear behavior in magnetized plasma regime in a controlled manner. The machine is specially designed to be a versatile laboratory device that can provide a number of magnetic and electric scenario to facilitate such studies. A total of 36 number of 20-turn magnet coils, designed such as to allow easy handling, is capable of producing a uniform, dc magnetic field of about 0.35 T inside the plasma chamber of diameter 0.30 m. Support structure of the coils is planned in an innovative way facilitating straightforward fabrication and easy positioning of the coils. Further special feature lies in the arrangement of the spacers between the coils that can be maneuvered rather easily to create different magnetic configurations. Various methods of plasma production can be suitably utilized according to the experimental needs at either end of the vacuum vessel. In the present paper, characteristics of a steady state plasma generated by electron cyclotron resonance method using 2.45 GHz microwave power are presented. Scans using simple probe drives revealed that a uniform and long plasma column having electron density {approx}3-5x10{sup 10} cm{sup -3} and temperature {approx}7-10 eV, is formed in the center of the plasma chamber which is suitable for wave launching experiments.

  4. The MaPLE device of Saha Institute of Nuclear Physics: construction and its plasma aspects.

    PubMed

    Pal, Rabindranath; Biswas, Subir; Basu, Subhasis; Chattopadhyay, Monobir; Basu, Debjyoti; Chaudhuri, Manis; Chowdhuri, Manis

    2010-07-01

    The Magnetized Plasma Linear Experimental (MaPLE) device is a low cost laboratory plasma device at Saha Institute of Nuclear Physics fabricated in-house with the primary aim of studying basic plasma physics phenomena such as plasma instabilities, wave propagation, and their nonlinear behavior in magnetized plasma regime in a controlled manner. The machine is specially designed to be a versatile laboratory device that can provide a number of magnetic and electric scenario to facilitate such studies. A total of 36 number of 20-turn magnet coils, designed such as to allow easy handling, is capable of producing a uniform, dc magnetic field of about 0.35 T inside the plasma chamber of diameter 0.30 m. Support structure of the coils is planned in an innovative way facilitating straightforward fabrication and easy positioning of the coils. Further special feature lies in the arrangement of the spacers between the coils that can be maneuvered rather easily to create different magnetic configurations. Various methods of plasma production can be suitably utilized according to the experimental needs at either end of the vacuum vessel. In the present paper, characteristics of a steady state plasma generated by electron cyclotron resonance method using 2.45 GHz microwave power are presented. Scans using simple probe drives revealed that a uniform and long plasma column having electron density approximately 3-5x10(10) cm(-3) and temperature approximately 7-10 eV, is formed in the center of the plasma chamber which is suitable for wave launching experiments.

  5. The MaPLE device of Saha Institute of Nuclear Physics: Construction and its plasma aspects

    NASA Astrophysics Data System (ADS)

    Pal, Rabindranath; Biswas, Subir; Basu, Subhasis; Chattopadhyay, Monobir; Basu, Debjyoti; Chaudhuri, Manis

    2010-07-01

    The Magnetized Plasma Linear Experimental (MaPLE) device is a low cost laboratory plasma device at Saha Institute of Nuclear Physics fabricated in-house with the primary aim of studying basic plasma physics phenomena such as plasma instabilities, wave propagation, and their nonlinear behavior in magnetized plasma regime in a controlled manner. The machine is specially designed to be a versatile laboratory device that can provide a number of magnetic and electric scenario to facilitate such studies. A total of 36 number of 20-turn magnet coils, designed such as to allow easy handling, is capable of producing a uniform, dc magnetic field of about 0.35 T inside the plasma chamber of diameter 0.30 m. Support structure of the coils is planned in an innovative way facilitating straightforward fabrication and easy positioning of the coils. Further special feature lies in the arrangement of the spacers between the coils that can be maneuvered rather easily to create different magnetic configurations. Various methods of plasma production can be suitably utilized according to the experimental needs at either end of the vacuum vessel. In the present paper, characteristics of a steady state plasma generated by electron cyclotron resonance method using 2.45 GHz microwave power are presented. Scans using simple probe drives revealed that a uniform and long plasma column having electron density ˜3-5×1010 cm-3 and temperature ˜7-10 eV, is formed in the center of the plasma chamber which is suitable for wave launching experiments.

  6. A Persistent Reformer: Jonathan Kozol's Work to Promote Equality in America. Adolescent Cultures, School and Society. Volume 59

    ERIC Educational Resources Information Center

    Ognibene, Richard, Ed.

    2012-01-01

    Jonathan Kozol has been a leading educational critic and social activist since 1967 when "Death at an Early Age," his book about racism in Boston's schools, was published and won a National Book Award. Since then, Kozol has written eleven more books which focus on such issues as segregation in schools and society, poverty, inequitable school…

  7. A Persistent Reformer: Jonathan Kozol's Work to Promote Equality in America. Adolescent Cultures, School and Society. Volume 59

    ERIC Educational Resources Information Center

    Ognibene, Richard, Ed.

    2012-01-01

    Jonathan Kozol has been a leading educational critic and social activist since 1967 when "Death at an Early Age," his book about racism in Boston's schools, was published and won a National Book Award. Since then, Kozol has written eleven more books which focus on such issues as segregation in schools and society, poverty, inequitable school…

  8. Teaching Eighteenth-Century Poetic Satire with a Competency-Based Approach: Jonathan Swift and Lady Mary Wortley Montagu

    ERIC Educational Resources Information Center

    Modia, María Jesús Lorenzo; Álvarez, Begoña Lasa

    2011-01-01

    The purpose of this essay is to analyse the teaching of literature with a competency-based approach. This is exemplified by means of a thorough study of a poetic duel between two relevant eighteenth-century writers, Jonathan Swift and Lady Mary Wortley Montagu, and more specifically, by means of the satires entitled respectively "The Lady's…

  9. Jonathan Rosen: building a dynamic union-based health and safety program.

    PubMed

    Rosen, Jonathan; McLaughlin, Kaci; Slatin, Craig

    2014-01-01

    Jonathan Rosen has spent more than 30 years building union-based health and safety programs. In the 1970s he was a union activist. In 1980 he became a union health and safety committee chair at a Milwaukee manufacturing firm. Following that, he had a nearly 20-year career with the New York State Public Employees Federation (PEF). He trained as an industrial hygienist and developed a highly regarded public sector union-based health and safety program. PEF's Health and Safety Department supported a network of union health and safety committees. Program accomplishments included innovative work on workplace violence prevention, indoor environmental quality, infectious diseases, and ergonomics. Mr. Rosen promoted collaboration among unions, helped support new activists, advocated tirelessly for injured workers, and formed an effective alliance with researchers. Rosen discusses essential strategies for mobilizing union members and gaining commitment to health and safety from unions, employers, and policy makers.

  10. Monitoring methods and predictive models for water status in Jonathan apples.

    PubMed

    Trincă, Lucia Carmen; Căpraru, Adina-Mirela; Arotăriţei, Dragoş; Volf, Irina; Chiruţă, Ciprian

    2014-02-01

    Evaluation of water status in Jonathan apples was performed for 20 days. Loss moisture content (LMC) was carried out through slow drying of wholes apples and the moisture content (MC) was carried out through oven drying and lyophilisation for apple samples (chunks, crushed and juice). We approached a non-destructive method to evaluate LMC and MC of apples using image processing and multilayer neural networks (NN) predictor. We proposed a new simple algorithm that selects the texture descriptors based on initial set heuristically chosen. Both structure and weights of NN are optimised by a genetic algorithm with variable length genotype that led to a high precision of the predictive model (R(2)=0.9534). In our opinion, the developing of this non-destructive method for the assessment of LMC and MC (and of other chemical parameters) seems to be very promising in online inspection of food quality. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. EDITORIAL: Editorial from the new Editor-in-Chief for 2014 Editorial from the new Editor-in-Chief for 2014

    NASA Astrophysics Data System (ADS)

    Graham, W. G.

    2014-02-01

    I am honoured to take on the leadership of Plasma Sources Science and Technology (PSST) as the successor to Professor Mark J Kushner, with whom I have had the pleasure to work on the journal for many years. Under Mark's insightful and energetic leadership over the last six years, PSST has cemented its position as the journal of choice within its subject area and is now one of the most successful journals in the field. In this first issue of 2014, I would like to reflect on some of the events and achievements of 2013. At the start of the year the PSST Editorial Board, recognizing the vital importance of atomic, molecular and optical (AMO) data to low-temperature plasma physics, agreed that PSST would accept papers reporting such new data, generated through both experiment and theory. Jonathan Tennyson joined the Editorial Board to represent this area. In March Anne Bourdon joined the Associate Editor team and has since then played a key part in the journal's review process alongside our other Editors. During the autumn, PSST moved to a new editorial management system. In December Deborah O'Connell was awarded the 2013 Hershkowitz Early Career Award and Review and joins the Editorial Board as of 2014. I would also like to thank Miles Turner for his work in leading the drafting of a guide on the details necessary in the reporting of the results of computer simulations; the main conclusions of this report have been incorporated into the journal policy. Overall 2013 has been another successful year for PSST; paper submissions were up by 8% on the previous year and there was the highest ever number of downloads of PSST papers in one year. Another noteworthy feature of 2013 was the continuing improvement in publication times while maintaining our high standards for acceptance and providing expert feedback coupled with encouragement particularly to younger researchers and groups. Largely as a result of the hard work of our referees and Associate Editors, the average time

  12. [2009 report from the editors].

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2010-01-01

    The editors of the Rev Clin Esp present the editorial course of action of the journal over the past year. We have up-dated the design of the journal, its contents (sections) and computerized the editorial process. We processed 467 manuscripts and made an editorial decision on 402 of them between November 2008 and October 2009. A total of 92 manuscripts (23%) were accepted. Fifteen (13%) out of the 119 original articles for which the editorial process was completed were accepted. Our goal for the year 2010 is to make the journal available on the Internet for all those who are subscribers to the Rev Clin Esp as well as for internal medicine residents (for which they must be members of each regional society). Other objectives of the editorial team are to edit the E-cases, for the journal to be a continuing education tool and that the coordinators of the work groups develop a monographic number at least once every two years. These actions aim to increase the impact factor and the quality of the Rev Clin Esp, official publication of the Spanish Society of Internal Medicine and of Spanish-speaking internal medicine physicians.

  13. EDITORIAL: Letter from the Editor Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Pashinin, Pavel P.

    2013-01-01

    Dear readers, contributors, and members of the world laser physics community. It is a great honour for us to introduce to you our new publishing partner, IOP Publishing, a subsidiary of the Institute of Physics, United Kingdom. IOP Publishing is a world renowned authority in producing journals, magazines, websites and services that enable researchers and research organizations to present their work to a world-wide audience. Laser Physics, the first English-language scientific journal in Russia, was founded in 1990 on the initiative of Alexander M Prokhorov, a pioneer and leader in laser physics research. Professor Prokhorov served as the first Editor-in-Chief of the journal until 2002. We are proud that it is our 23rd year of publishing Laser Physics and our 10th year of publishing Laser Physics Letters. We would like to honour the memory of our friend, late Professor Igor Yevseyev, whose enthusiasm and unwavering dedication to our journals contributed most significantly to their success. It was initially his idea in 2011 to approach IOP with a partnership proposal. We deeply regret that he is no longer with us as we enter this productive alliance. Now, in partnership with IOP, we are turning a new page in providing world-wide access to the cutting-edge research results in our journals, serving our well established global audience. We see new horizons opening for our journals for years to come and hope that our readers share our enthusiasm and aspirations. Please accept our best wishes for all your new scientific endeavors in the exciting field of laser physics.

  14. The histone deacetylase inhibitor SAHA sensitizes acute myeloid leukemia cells to a combination of nucleoside analogs and the DNA-alkylating agent busulfan.

    PubMed

    Song, Guiyun; Valdez, Benigno C; Li, Yang; Dominguez, Jose R; Corn, Paul; Champlin, Richard E; Andersson, Borje S

    2014-07-01

    Fludarabine (Flu), clofarabine (Clo) and busulfan (Bu) are used in allogeneic hematopoietic stem cell transplant (allo-HSCT). We reported that combining [Flu + Clo + Bu] had a synergistic cytotoxicity in AML cells. We hypothesized that combining [Flu + Clo + Bu] with the histone deacetylase inhibitor SAHA will further enhance cytotoxicity. We exposed the acute myeloid leukemia (AML) cell lines KBM3/Bu250(6) and OCI-AML3 to Flu, Clo, Bu and SAHA alone and in various combinations. [Flu + Clo + Bu + SAHA] resulted in synergistic cytotoxicity, which can be attributed to (1) activated DNA-damage response and cell cycle checkpoint activation through the ATM-CHK2-P53 (or P73) pathway or ATM-CHK2-cdc25-cdc2 pathway, (2) histone modifications and (3) activated apoptosis pathway. The [Flu + Clo + Bu + SAHA] combination causes mitochondrial outer membrane permeabilization, leakage of cytochrome c and Smac/Diablo into the cytosol with caspase activation, and release of apoptosis-inducing factor (AIF) into the nucleus resulting in nuclear fragmentation and cell death. These results provide a mechanistic basis for using SAHA in future clinical trials with double nucleoside analog-busulfan combinations in pretransplant conditioning therapy.

  15. Carfilzomib combined with suberanilohydroxamic acid (SAHA) synergistically promotes endoplasmic reticulum stress in non-small cell lung cancer cell lines

    PubMed Central

    Hanke, Neale T.; Garland, Linda L.; Baker, Amanda F.

    2015-01-01

    Purpose The endoplasmic reticulum (ER) stress response is a therapeutic target for pharmacologic intervention in cancer cells. We hypothesized that combining carfilzomib (CFZ), a proteasome inhibitor, and vorinostat (SAHA), a histone deacetylase (HDAC) inhibitor, would synergistically activate ER stress in non-small cell lung cancer (NSCLC) cell lines resulting in enhanced anti-tumor activity. Methods Five NSCLC cell lines were treated with CFZ, SAHA, or the combination and cell proliferation measured using the MTT assay. Calcusyn software was utilized to determine the combination index as a measure of synergy. Cell viability and cytotoxicity were measured using trypan blue exclusion, CellTiter and CytoTox assays. Western blot was used to measure markers of apoptosis, ER stress, and oxidative stress related proteins. Reactive oxygen species (ROS) was measured using the fluorophore CM-H2DCFDA. Results Synergistic activity was observed for all cell lines following 48 and 72 hours of combined treatment. H520 and A549 cell lines were used to assess viability and apoptosis. In both cell lines, increased death and cleaved caspase-3 was observed following combination treatment as compared with single agent treatments. Combination therapy was associated with upregulation of ER stress regulated proteins including activating transcription factor 4, GRP78/BiP, and C/EBP homologous protein. Both cell lines also showed increased ROS and the oxidative stress-related protein, heat shock protein 70. Conclusion Combining proteasome inhibition with HDAC inhibition enhances ER stress which may contribute to the synergistic anti-cancer activity observed in NSCLC cell lines. Further pre-clinical and clinical studies of CFZ + SAHA in NSCLC are warranted. PMID:26385374

  16. Validity of Saha's equation of thermal ionization for negatively charged spherical particles in complex plasmas in thermal equilibrium

    SciTech Connect

    Sodha, M. S.; Mishra, S. K.

    2011-04-15

    The authors have discussed the validity of Saha's equation for the charging of negatively charged spherical particles in a complex plasma in thermal equilibrium, even when the tunneling of the electrons, through the potential energy barrier surrounding the particle is considered. It is seen that the validity requires the probability of tunneling of an electron through the potential energy barrier surrounding the particle to be independent of the direction (inside to outside and vice versa) or in other words the Born's approximation should be valid.

  17. Sir William Wilde: an enlightened editor.

    PubMed

    O'Doherty, M

    2016-05-01

    This paper examines Sir William Wilde's peculiar genius as editor, his contribution to the Irish Journal of Medical Science in ensuring its endurance and making it a treasure-house of the history of medicine in Ireland.

  18. Richard Gilbert, Reporter and Assistant City Editor.

    ERIC Educational Resources Information Center

    Bender, Larry

    1988-01-01

    Looks at the experiences of Richard Gilbert, reporter and assistant editor for "The Herald Telephone," a daily newspaper in Bloomington, Indiana, and discusses Gilbert's suggested guidelines for high school journalism advisers. (MS)

  19. Ethical issues faced by nursing editors.

    PubMed

    Freda, Margaret Comerford; Kearney, Margaret H

    2005-06-01

    This study reports on ethical issues faced by editors of nursing journals, a topic which has not appeared in the nursing literature. A survey of nursing editors (n = 88)was conducted via e-mail; this article is the content analysis of survey questions about ethics. Eight categories of ethical issues emerged: problems with society/association/publisher; decisions about inflammatory submissions; informed consent or IRB issues; conflicts of interest; advertising pressures; duplicate publications and/or plagiarism; difficult interactions with authors; and authorship. Some issues were similar to those published about medical editors; however, others were unique. This study can assist authors to better understand some of the ethical issues in publishing, can help editors to view their issues in the context of what others experience, and can assist societies and publishers to work toward avoiding these ethical issues in the future. Professional discussions about ethics in nursing publications should be the subject of ongoing research and scientific inquiry.

  20. Headline Ideas from Reporters Help Copy Editors.

    ERIC Educational Resources Information Center

    Haber, Marian Wynne

    1984-01-01

    Presents a method that has student reporters write headline suggestions on their stories before submission to avoid nonsignificant headlines. This technique was judged worthwhile by three professional copy editors. (CRH)

  1. Report of the editors, 2014.

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2015-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) Objectives and attainments in 2014, (b) Editorial activity, 2014, and (c) 2013 impact factor. In 2014 we achieved the 5 planned objectives. We have published the 9 programmed issues and 103% of the planned papers according to the usual fixed sections. We emphasize the publication of 29 editorials, 21 of which are signed by prestigious foreign authors. From the first January to the 30th September 2014 we received 421 manuscripts (46.8 manuscripts per month), a slight lower figure to that obtained in 2013 (50.9 manuscripts per month). The acceptance rate of the 404 manuscripts whose editorial process has been concluded was 32.3% (originals, 22.4%). We asked for 315 revisions to 240 reviewers and we received 53.3% revisions in less than two weeks (10.4 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 18,3 (less than half than in 2009). For «originals» this figure has dropped from 56,6 days in 2009 to 26.6 days in 2014. The mean time elapsed from manuscript reception to its on-line publication was 103 days. In 2014 the collaboration with the working groups from the Internal Medicine Spanish Foundation (FEMI) has reported 11 published manuscripts. In July 2014 we were informed that the Journal Citation Reports gave Rev Clin Esp an Impact Factor of 1,314 (year 2013). This Impact Factor without self-citations would have been 0.705 (in 2009 the global impact factor was 0,584). With the Editorial Committee farewell we welcome the new editorial team and we sincerely thank the SEMI Steering Committee, our colleagues, journal officers, reviewers, readers and authors that since 2009 have trusted on our editorial work.

  2. [Report of the editors, 2010].

    PubMed

    García Puig, Juan; Alonso-Vega, Gabriel Gaspar; Blanco, Juan José Ríos

    2011-01-01

    The Editors of the Rev Clin Esp inform herein on their editorial activity in the last year (November 2009 to October 2010) according to three different sections: (a) Objectives and achievements during 2010, (b) editorial activity, and (c) objectives for 2011. During 2010, we have updated the editorial algorithm (manuscript time lag). We have developed the "E-case reports" section and we have linked the abstracts of the Annual Congress of the Spanish Society of Internal Medicine (SEMI) to a journal supplement (electronically available). Since 2010, the subscribers have been able to receive all of the contents of the Rev Clin Esp on-line and to perform self-evaluations in order to obtain 1.7 credits per each journal issue (continuing education). In 2010 we handled 402 manuscripts (7.2% more than in 2009), 35% of which were accepted for publication. We asked 186 reviewers for their expert opinion, 75% of whom sent their reports in less than two weeks. The mean time needed to reach an editorial decision concerning original manuscripts ("accepted / rejected") was 44.5 days and for papers not sent to external reviewers 19.5 days. Collaboration with the work groups produced good results (2.4 published manuscripts per issue), but this could be improved if all the groups collaborated in all the journal sections. Our objectives for 2011 are to complete the renewal of the Rev Clin Esp scientific committee, in accordance with the SEMI Council, and to continue to proceed with the actions initiated to increase the journal impact factor. Rev Clim Esp is an open forum for all internal medicine specialists. Responsibility falls on all of us to collaborate in order to make our journal a little better day by day.

  3. 2012 Editors' Citations for Excellence in Refereeing

    NASA Astrophysics Data System (ADS)

    2013-09-01

    One of the most important services performed for AGU is the conscientious reviewing of submitted papers. Because of the nature of the reviewing process, this service is also one of the least recognized. Every year editors are asked to select the outstanding reviewers from the previous year. The reviewers listed below have been cited by editors of AGU journals and Eos for excellence in refereeing. These individuals are to be commended for consistently providing constructive and thoughtful reviews.

  4. 2013 Editors' Citations for Excellence in Refereeing

    NASA Astrophysics Data System (ADS)

    2014-06-01

    One of the most important services performed for AGU is the conscientious reviewing of submitted papers. Because of the nature of the reviewing process, this service is also one of the least recognized. Every year editors are asked to select the outstanding reviewers from the previous year. The reviewers listed below have been cited by editors of AGU journals and Eos for excellence in refereeing. These individuals are to be commended for consistently providing constructive and thoughtful reviews.

  5. DeviceEditor visual biological CAD canvas

    PubMed Central

    2012-01-01

    Background Biological Computer Aided Design (bioCAD) assists the de novo design and selection of existing genetic components to achieve a desired biological activity, as part of an integrated design-build-test cycle. To meet the emerging needs of Synthetic Biology, bioCAD tools must address the increasing prevalence of combinatorial library design, design rule specification, and scar-less multi-part DNA assembly. Results We report the development and deployment of web-based bioCAD software, DeviceEditor, which provides a graphical design environment that mimics the intuitive visual whiteboard design process practiced in biological laboratories. The key innovations of DeviceEditor include visual combinatorial library design, direct integration with scar-less multi-part DNA assembly design automation, and a graphical user interface for the creation and modification of design specification rules. We demonstrate how biological designs are rendered on the DeviceEditor canvas, and we present effective visualizations of genetic component ordering and combinatorial variations within complex designs. Conclusions DeviceEditor liberates researchers from DNA base-pair manipulation, and enables users to create successful prototypes using standardized, functional, and visual abstractions. Open and documented software interfaces support further integration of DeviceEditor with other bioCAD tools and software platforms. DeviceEditor saves researcher time and institutional resources through correct-by-construction design, the automation of tedious tasks, design reuse, and the minimization of DNA assembly costs. PMID:22373390

  6. How are Editors Selected, Recruited and Approved?

    PubMed

    Teixeira da Silva, Jaime A; Al-Khatib, Aceil

    2016-11-28

    The editors of scholarly journals have a duty to uphold and promote the highest standards of ethical conduct of research. They also have a responsibility to maintain the integrity of the literature, and to promote transparency and honesty in reporting research findings. In the process of screening manuscripts they receive for possible publication, editors have the obligation to report infractions to the institutions of offending authors, and request an investigation. Since editors can reject a paper on ethical grounds, they can be considered to be the guardians of ethics who should express high ethical standards in conducting and publishing their own research. An examination of several publishers' websites reveals no such requirement or clear selection criteria for journal editors. Therefore, we aim to discuss the factors that publishers, in a broad sense, should consider when selecting editors for scholarly journals and believe that such criteria should be made public to ensure accountability. This would restore some of the eroding public trust in disseminated research, fortify confidence in the composition and qualification of members of an editorial board, and help to protect the reputations of publishers and editors.

  7. EDITORIAL: Message from the Editor Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2012-01-01

    Board Members, Guest Editors of special editions and those referees who were already listed in the last years. The following people have been selected: Marina Becoulet, CEA Cadarache, France Russell Doerner, University of California - San Diego, USA Emiliano Fable, Max-Planck-Institut fuer Plasmaphysik, Germany Akihide Fujisawa, Kyushi University, Japan Gerardo Giruzzi, CEA Cadarache, France Grigory Kagan, LANL, USA Morten Lennholm, CCFE, UK Akinobu Matsuyama, NIFS, Japan Peter Stangeby, University of Toronto, Canada Leonid Zakharov, PPPL, USA In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2011. Our thanks to them! Authors The winner of the 2011 Nuclear Fusion Award is H. Urano, for the paper 'Dimensionless parameter dependence of H-mode pedestal width using hydrogen and deuterium plasmas in JT-60U' (Nucl. Fusion 48 045008). The award was presented at the Plasma Conference 2011 (Joint meeting of 28th JSPF Annual Meeting, The 29th Symposium on Plasma Processing, and Division of Plasma Physics, 2011 Autumn Meeting of The Physical Society of Japan). This is the sixth year that the International Atomic Energy Agency (IAEA) has awarded an annual prize to honour exceptional work published in Nuclear Fusion. IOP Publishing has generously made a contribution of $2500 to the award. The Nuclear Fusion Electronic Archive The journal's electronic archive has been online since the beginning of the year. The archive has been a roaring success and has contributed to the nearly 300 000 downloads of journal papers in 2011. The archive can be accessed via http://iopscience.iop.org/0029-5515/page/Archive. It has direct links to 16 landmark papers, from authors such as Artsimovich and Mercier. The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors and referees, so its success is also

  8. [Report of the editors, 2013].

    PubMed

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2014-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day

  9. EDITORIAL: Letter from the Editor Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2011-01-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2010, and special thanks go to those of you who have kindly reviewed articles for the journal. I would also like to take this opportunity to update you on some of the developments on the journal and look ahead to 2011. As many of you are no doubt aware, our impact factor (a measure of the average number of times recent papers are referred to by others) is currently 1.317. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization (Thomson ISI) agreeing with my own assessment. Measurement Science and Technology is a journal with a broad scope covering new measurement techniques in all fields of science and engineering. I therefore find it particularly enjoyable to read summaries of recent research in our strong topical review programme as these cover many varied topics of interest. In 2010 several interesting articles by international leaders in their field were published, for example: Single-photon generation and detection, by G S Buller and R J Collins of Heriot-Watt University [1]. Fluorescence lifetime imaging microscopy in life sciences, by Jan Willem Borst and Antonie J W G Visser, from the Microspectroscopy Centre of Wageningen University [2]. Biological and chemical sensors for cancer diagnosis, by Elfriede Simon of Siemens AG [3]. I hope that these articles, and the others published in 2010 and now in 2011, will provide a useful overview for our readers, and be helpful to new researchers. When speaking to young researchers I am particularly aware that having their articles published in a timely fashion is important, and I am pleased that our publication times are highly competitive, with most authors receiving a

  10. [The Chilean Association of Biomedical Journal Editors].

    PubMed

    Reyes, H

    2001-01-01

    On September 29th, 2000, The Chilean Association of Biomedical Journal Editors was founded, sponsored by the "Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)" (the Governmental Agency promoting and funding scientific research and technological development in Chile) and the "Sociedad Médica de Santiago" (Chilean Society of Internal Medicine). The Association adopted the goals of the World Association of Medical Editors (WAME) and therefore it will foster "cooperation and communication among Editors of Chilean biomedical journals; to improve editorial standards, to promote professionalism in medical editing through education, self-criticism and self-regulation; and to encourage research on the principles and practice of medical editing". Twenty nine journals covering a closely similar number of different biomedical sciences, medical specialties, veterinary, dentistry and nursing, became Founding Members of the Association. A Governing Board was elected: President: Humberto Reyes, M.D. (Editor, Revista Médica de Chile); Vice-President: Mariano del Sol, M.D. (Editor, Revista Chilena de Anatomía); Secretary: Anna María Prat (CONICYT); Councilors: Manuel Krauskopff, Ph.D. (Editor, Biological Research) and Maritza Rahal, M.D. (Editor, Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello). The Association will organize a Symposium on Biomedical Journal Editing and will spread information stimulating Chilean biomedical journals to become indexed in international databases and in SciELO-Chile, the main Chilean scientific website (www.scielo.cl).

  11. A standard syntax-directed editor for hyperprogramming systems

    SciTech Connect

    Zhogolev, E.A.; Kuz`menkova, E.A.; Mailingova, O.L.; Poprygaev, E.V.

    1995-05-01

    The main operations of a syntax-directed editor are considered. The requirements to the standard syntax-directed editor are stated. The structure of the standard syntax-directed editor and the functions of its components are discussed. The language base properties needed for syntax-directed editor development are described. Methods for transforming the standard syntax-directed editor into a specialized one are carried out.

  12. AGU Publications Volunteers Feted At Elegant Editors' Evening

    NASA Astrophysics Data System (ADS)

    Panning, Jeanette

    2013-01-01

    The 2012 Fall Meeting Editors' Evening, held at the City Club of San Francisco, was hosted by the Publications Committee and is the premier social event for editors and associate editors attending the Fall Meeting. The evening commenced with a welcome from Carol Finn, incoming AGU president, in which she expressed her thanks to the editors and associate editors for volunteering their time to benefit AGU.

  13. Stem cells - A very short introduction Jonathan Slack Stem cells - A very short introduction Oxford University Press 144pp £7.99 9780199603381 9780199603381 [Formula: see text].

    PubMed

    2012-10-31

    The latest addition to this popular pocket-book series from Oxford University Press is by Jonathan Slack, a prominent researcher and director of the Stem Cell Institute at the University of Minnesota in the United States.

  14. Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63

    PubMed Central

    Ogata, Takehiro; Nakamura, Mizuyo; Sang, Meijie; Yoda, Hiroyuki; Hiraoka, Kiriko; Yin, Danjing; Sang, Mexiang; Shimozato, Osamu

    2017-01-01

    Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this study, we have found for the first time that RUNX2/mutant p53/TAp63-regulatory axis has a pivotal role in the determination of SAHA sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells. According to our present results, MiaPaCa-2 cells responded poorly to SAHA. Forced depletion of mutant p53 stimulated SAHA-mediated cell death of MiaPaCa-2 cells, which was accomapanied by a further accumulation of γH2AX and cleaved PARP. Under these experimental conditions, pro-oncogenic RUNX2 was strongly down-regulated in mutant p53-depleted MiaPaCa-2 cells. Surprisingly, RUNX2 silencing augmented SAHA-dependent cell death of MiaPaCa-2 cells and caused a significant reduction of mutant p53. Consistent with these observations, overexpression of RUNX2 in MiaPaCa-2 cells restored SAHA-mediated decrease in cell viability and increased the amount of mutant p53. Thus, it is suggestive that there exists a positive auto-regulatory loop between RUNX2 and mutant p53, which might amplify their pro-oncogenic signals. Intriguingly, knockdown of mutant p53 or RUNX2 potentiated SAHA-induced up-regulation of TAp63. Indeed, SAHA-stimulated cell death of MiaPaCa-2 cells was partially attenuated by p63 depletion. Collectively, our present observations strongly suggest that RUNX2/mutant p53/TAp63-regulatory axis is one of the key determinants of SAHA sensitivity of p53-mutated pancreatic cancer cells. PMID:28671946

  15. Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.

    PubMed

    Ogata, Takehiro; Nakamura, Mizuyo; Sang, Meijie; Yoda, Hiroyuki; Hiraoka, Kiriko; Yin, Danjing; Sang, Mexiang; Shimozato, Osamu; Ozaki, Toshinori

    2017-01-01

    Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this study, we have found for the first time that RUNX2/mutant p53/TAp63-regulatory axis has a pivotal role in the determination of SAHA sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells. According to our present results, MiaPaCa-2 cells responded poorly to SAHA. Forced depletion of mutant p53 stimulated SAHA-mediated cell death of MiaPaCa-2 cells, which was accomapanied by a further accumulation of γH2AX and cleaved PARP. Under these experimental conditions, pro-oncogenic RUNX2 was strongly down-regulated in mutant p53-depleted MiaPaCa-2 cells. Surprisingly, RUNX2 silencing augmented SAHA-dependent cell death of MiaPaCa-2 cells and caused a significant reduction of mutant p53. Consistent with these observations, overexpression of RUNX2 in MiaPaCa-2 cells restored SAHA-mediated decrease in cell viability and increased the amount of mutant p53. Thus, it is suggestive that there exists a positive auto-regulatory loop between RUNX2 and mutant p53, which might amplify their pro-oncogenic signals. Intriguingly, knockdown of mutant p53 or RUNX2 potentiated SAHA-induced up-regulation of TAp63. Indeed, SAHA-stimulated cell death of MiaPaCa-2 cells was partially attenuated by p63 depletion. Collectively, our present observations strongly suggest that RUNX2/mutant p53/TAp63-regulatory axis is one of the key determinants of SAHA sensitivity of p53-mutated pancreatic cancer cells.

  16. [Jonathan Swift's asylum in Dublin--Ireland's introduction to institutional psychiatry 250 years ago].

    PubMed

    Reuber, M

    1995-09-01

    250 years ago, the satirical writer and clergyman Jonathan Swift from Dublin (1667-1745) founded the first Irish lunatic asylum. Rejecting the theories put forward by the English philosopher Thomas Hobbes and the doctor Thomas Willis, he was influenced by the ideas of the Scottish doctor and the "enlightened" thinker John Locke. Swift's St. Patrick's Hospital did not, however, realise a new philosophical concept: architecture and therapeutic approach of the new institution were clearly modelled on the much older Hospital of St. Mary of Bethlehem ( = Bedlam). Despite its conservative conceptual basis, the first institution dedicated to the mentally ill and intellectually subnormal in Ireland became a starting point for the apparantly unstoppable expansion of the, at one time, most comprehensive asylum system in the world. After Swift's Hospital had been enlarged twice at the tax-payers' expense (1778, 1793), the administration decided to relieve the institution by erecting the Richmond Asylum (1810), the first public asylum in Ireland. When this establishment also became overcrowded, in 1817, legislation was passed which led to the establishment of the oldest system of public asylums in Europe.

  17. Understanding Recent Home-Birth Research: An Interview With Drs. Melissa Cheyney and Jonathan Snowden.

    PubMed

    Cheyney, Melissa

    2016-01-01

    In the past month, two new studies have been released-one in The New England Journal of Medicine (NEJM; Snowden et al., 2015) and the other in the Canadian Medical Association Journal (Hutton et al., 2015)-comparing out-of-hospital birth outcomes to hospital birth outcomes. These studies join a growing body of literature that consistently shows high rates of obstetric intervention in hospitals and also show low risk to neonates regardless of setting. However, the recent NEJM study found a small but statistically significant increase in risk for perinatal mortality for babies born out of hospital. Jeanette McCulloch of BirthSwell (http://www.birthswell.com) interviews Melissa Cheyney, PhD, CPM, LDM, medical anthropologist, chair of the Midwives Alliance Division of Research, and lead author on the largest study of outcomes for planned home births in the United States to date (Cheyney et al., 2014a), and Jonathan Snowden, PhD, epidemiologist and assistant professor in the Department of Obstetrics and Gynecology and School of Public Health at Oregon Health and Science University. Snowden is also the lead author of the recent NEJM study.

  18. Language and memory disorder in the case of Jonathan Swift: considerations on retrospective diagnosis.

    PubMed

    Lorch, Marjorie

    2006-11-01

    The cause of behavioural changes described by Alzheimer for his original case, Auguste D., has been recently reconfirmed by histological examination. However, there has been active speculation regarding the cause of behavioural changes exhibited by the political satirist Jonathan Swift (1667-1745) during the final three years of his life for over 250 years. Swift's symptoms of cognitive changes, memory impairment, personality alterations, language disorder and facial paralysis have all been apportioned differing levels of significance in various attempts at retrospective diagnosis. The various medical arguments put forward from the 18th through 20th centuries will be critically examined. The diagnoses considered refer to evolving theories of insanity, phrenology, localization of cortical function, hydrocephalus, psychoanalysis, aphasia, dementia and depression in ageing. Re-consideration of the attempts to re-diagnose Swift's final mental state by the leading neurological thinkers of the day, including Wilde (The Closing Years of Dean Swift's Life. Dublin: Hodges and Smith, 1849), Bucknill (1882), Osler [Osler's textbook Principles and Practice of Medicine (1892); published in St Thomas's Hospital Gazette (London) 1902; 12: 59-60), Brain (Irish Med J 1952: 320-1 and 337-346) and Boller and Forbes (J Neurol Sci 1998; 158: 125-133) reveal the changing attitudes regarding the significance of behavioural symptoms to neurological diagnosis from the 18th century to the present day.

  19. 1999 Jonathan E. Rhoads lecture. Isotopic metaprobes, nutrition, and the roads ahead.

    PubMed

    Young, V R; Ajami, A M

    1999-01-01

    The 1999 Jonathan E. Rhoads lecture, delivered by Vernon R. Young at the annual meeting of American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), San Diego, February 2, 1999, with the printed version coauthored with Alfred M. Ajami, is concerned with the application of isotopic probes and how, in particular, they may be used as diagnostic tools to enhance the role of nutrition in the comprehensive medical management of the patient. Following a brief review of the early uses of stable isotopes in metabolic research we consider the present and possible future application of stable isotope probes. The concept of a "gateway" enzyme in a discrete biochemical pathway and how the flow of substrate through this step might be assessed by giving a "metaprobe" is developed. The specific and desirable structural requirements of the metaprobe are considered. A number of examples are given that further exploit the concepts of "underground" metabolism and of metabolic "hijackers." It is our view that we are on the verge of a new era where, for the many pragmatic and exciting reasons discussed, stable isotope probes will find and increasing use in the practice of clinical medicine and in the preventive and public health areas.

  20. Jonathan Osborne (1794-1864) and his recognition of conduction aphasia in 1834.

    PubMed

    Breathnach, C S

    2011-03-01

    In 1833 an accomplished 26-year-old linguist suffered a non-paralytic stroke. After he recovered, though he could utter a variety of syllables with ease, he spoke an unintelligible jargon that caused him to be mistaken as a foreigner. He was examined repeatedly over the course of a year by Jonathan Osborne (1794-1864), a Dublin physician and professor of materia medica, who found that the patient understood whatever was said to him, that he could read and write fluently, but had difficulty repeating words read to him or in reading aloud. Osborne recommended that he learn to speak English, his natural language, de novo and over 8 months measured his considerable improvement. To explain the patient's singular difficulty in repeating spoken words Osborne argued it was 'highly probable that, having been conversant with five languages, the muscular apparatus ranged among them, forming a kind of polyglot jargon [that was] wholly unintelligible' and the patient was 'unable to penetrate into and select the contents of the store according as the [words] were required'. The discrepancy between comprehension and repetition was later termed conduction aphasia.

  1. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2009-01-01

    Marella de Angelis and her colleagues on precision gravimetry using atomic sensors and from Dr Peter Becker on determination of the Avogadro constant via enriched silicon-28. I recommend setting up a free e-mail alert so that you can read them as soon as they are published! As many of you are already aware, our impact factor (a measure of the average number of times recent papers are referred to by others) has risen again to 1.297. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization (Thomson ISI) agreeing with my own assessment. Of course the publication of high quality articles in the journal is dependent both on you the authors who trust us with the publication of your best work and on our referees and Editorial Board Members who we depend on to maintain the high standards you have grown to expect. I must also thank our referees for their rapid response when asked to review papers for Measurement Science and Technology. On average, authors receive a decision on their article in 45 days. Therefore I would like to end this message by saying thank you again to all those who have contributed to our success in the past year, and wish you all the best for a successful 2009!

  2. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2008-01-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2007, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal. As many of you are no doubt aware, our latest impact factor (a measure of the average number of times recent papers are referred to by others) has risen to 1.228. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. The popularity of the journal amongst authors and readers has prompted us to introduce a new subject classification for articles, to make it easier for readers to find articles of interest. The eight subject categories are: Measurement theory and practical developments (e.g. precision measurements, metrology, new measurement principles, signal processing techniques, theory of measurement, calibration); Sensors and sensing systems (based on physical, chemical or biological principles; micro- and nano-scale systems; sensors for physical, chemical and biological quantities); Optical and laser based techniques (e.g. fibre optics, interferometry, etc); Fluid mechanics measurements (e.g. fluid flow, velocimetry, particle sizing, etc); Imaging techniques (e.g. tomography, microscopy, holography, THz, etc); Spectroscopy (e.g. optical, acoustic, dielectric, MS, NMR, ESR, IR, UV-VIS, fluorescence, PCS, x-ray, etc); New and improved techniques for materials evaluation (e.g. non-destructive testing and evaluation, structural measurements); Novel instrumentation. We kindly ask you to assign your paper to a category when you send it to the journal. In order to maintain our rapid

  3. EDITORIAL: Message from the Editor

    NASA Astrophysics Data System (ADS)

    Thomas, Paul

    2008-01-01

    To begin, I would like to wish our readers, authors, referees and Board of Editors a successful and happy 2008 and thank them for their contributions to Nuclear Fusion in 2007. I took over the editorship of Nuclear Fusion in January, and the year has been one in which the community as a whole has been busier than ever with a variety of duties associated with the ITER project. It was with pride that we published the Progress in the ITER Physics Basis in the June issue of the journal (stacks.iop.org/NF/47/i=6). The task undertaken by the coordinators, authors and referees was a daunting one but one which led to an outstandingly successful issue. The response from readers has been phenomenal and there were in the region of 10 000 downloads of papers in the first month following publication. Looking to 2008 and beyond, the journal will endeavour to continue to support the work of the fusion community. Refereeing As we have done since January 2005, we would like to thank our top ten most loyal referees who have helped the journal with its double-referee peer-review procedure in the past year. At the Nuclear Fusion Editorial Office we are fully aware of the load we put on the shoulders of our referees. At the end of 2004 the Editorial Board decided that a gesture of gratitude should be made to our most loyal referees. We offer them a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. To select the top referees we have adopted the criterion that a researcher should have acted as a referee or adjudicator for at least three different manuscripts during the period from summer 2006 to the end of 2007. We have excluded our Board members and those referees who were already listed in the top ten in the last two years. According to our records the following people met this criterion. Congratulations and many, many thanks! H.L. Berk (Texas University, USA) J.S. DeGrassie (GAT, USA) C. Deutsch (Paris University, France) N. Hayashi (JAEA

  4. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

    PubMed Central

    Ruefli, Astrid A.; Ausserlechner, Michael J.; Bernhard, David; Sutton, Vivien R.; Tainton, Kellie M.; Kofler, Reinhard; Smyth, Mark J.; Johnstone, Ricky W.

    2001-01-01

    Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate apoptosis. However, the upstream events leading to drug-induced mitochondrial perturbation have remained poorly defined. We have used a variety of physiological and pharmacological inhibitors of distinct apoptotic pathways to analyze the manner by which suberoylanilide hydroxamic acid (SAHA), a chemotherapeutic agent and histone deacetylase inhibitor, induces cell death. We demonstrate that SAHA initiates cell death by inducing mitochondria-mediated death pathways characterized by cytochrome c release and the production of reactive oxygen species, and does not require the activation of key caspases such as caspase-8 or -3. We provide evidence that mitochondrial disruption is achieved by means of the cleavage of the BH3-only proapoptotic Bcl-2 family member Bid. SAHA-induced Bid cleavage was not blocked by caspase inhibitors or the overexpression of Bcl-2 but did require the transcriptional regulatory activity of SAHA. These data provide evidence of a mechanism of cell death mediated by transcriptional events that result in the cleavage of Bid, disruption of the mitochondrial membrane, and production of reactive oxygen species to induce cell death. PMID:11535817

  5. A Command Editor Tool for NEXTSTEP

    DTIC Science & Technology

    1993-07-01

    appears and presents the hierarchy of CEMenuCells A Command Editor Tool for NEXTSTEP 2 of 27 m arble Final Report for Contract # DAAHO1-93-C-R013 in the...icon, "Default" status, state list, textual description, tool sta- A Command Editor Tool for NEXTSTEP 3 of 27 m arble Final Report for Contract... arble Final Report for Contract # DAAH01-93-C-R013 FIGURE 7 Configuration of a TAV 3.0.. Acietr O ev 3.1 luBman d aetn Cmoe a ConQ summw t. Paletta e

  6. EDITORIAL: Letter from the Editor

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2006-12-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2006, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal this year. As many of you are no doubt aware our impact factor (a measure of the average number of times recent papers are referred to by others) has remained above 1 for the second year in a row. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. This year we have welcomed several new faces to our Editorial Board and International Advisory Board. We are delighted to welcome Professor Hirofumi Yamada of the University of Kyoto as a representative from Japan. From China we have been joined by Professor Xuzong Chen of Peking University and Professor Zhiyi Wei of Chinese Academy of Sciences, Beijing. Professor Ivan Marusic from University of Minnesota and Dr Paul Williams of the National Institute of Standards and Technology in Boulder have joined as North American representatives. As usual you will be able to submit your articles through them or direct to the Editorial Office in Bristol, UK. As part of our ongoing initiative to give our authors' work the highest visibility, all articles are freely available online for 30 days from the date of publication, allowing all researchers to read and view the latest research as soon as it is published, and this year there have been many interesting articles to read! As regular readers are aware, Measurement Science and Technology publishes special issues and features, which highlight an area of current interest. This year's topics included

  7. Open Simulation Laboratories [Guest editors' introduction

    SciTech Connect

    Alexander, Francis J.; Meneveau, Charles

    2015-09-01

    The introduction for the special issue on open simulation laboratories, the guest editors describe how OSLs will become more common as their potential is better understood and they begin providing access to valuable datasets to much larger segments of the scientific community. Moreover, new analysis tools and ways to do science will inevitably develop as a result.

  8. Open Simulation Laboratories [Guest editors' introduction

    DOE PAGES

    Alexander, Francis J.; Meneveau, Charles

    2015-09-01

    The introduction for the special issue on open simulation laboratories, the guest editors describe how OSLs will become more common as their potential is better understood and they begin providing access to valuable datasets to much larger segments of the scientific community. Moreover, new analysis tools and ways to do science will inevitably develop as a result.

  9. Are Editors Out of the Tenure Process?

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    University presses have complained for years that tenure committees unfairly expect their editors to be arbiters of what counts as tenure-worthy work. At the same time, the presses have been caught in a business-side squeeze between dwindling sales (and shrinking subsidies) and the ever-greater pressure on scholars to publish. In this article, the…

  10. Editors, Teachers Disagree about Definition of Plagiarism.

    ERIC Educational Resources Information Center

    Chaney, Jerry; Duncan, Tom

    1985-01-01

    Describes a study of plagiarism policies in journalism schools and newsrooms. Concludes that instructors felt educating students about plagiarism was one of the most important services journalism schools offer, but editors felt that plagiarism standards must be set in the real world of the newsroom. (HTH)

  11. A Visual Editor in Java for View

    NASA Technical Reports Server (NTRS)

    Stansifer, Ryan

    2000-01-01

    In this project we continued the development of a visual editor in the Java programming language to create screens on which to display real-time data. The data comes from the numerous systems monitoring the operation of the space shuttle while on the ground and in space, and from the many tests of subsystems. The data can be displayed on any computer platform running a Java-enabled World Wide Web (WWW) browser and connected to the Internet. Previously a special-purpose program bad been written to display data on emulations of character-based display screens used for many years at NASA. The goal now is to display bit-mapped screens created by a visual editor. We report here on the visual editor that creates the display screens. This project continues the work we bad done previously. Previously we had followed the design of the 'beanbox,' a prototype visual editor created by Sun Microsystems. We abandoned this approach and implemented a prototype using a more direct approach. In addition, our prototype is based on newly released Java 2 graphical user interface (GUI) libraries. The result has been a visually more appealing appearance and a more robust application.

  12. Are Editors Out of the Tenure Process?

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    University presses have complained for years that tenure committees unfairly expect their editors to be arbiters of what counts as tenure-worthy work. At the same time, the presses have been caught in a business-side squeeze between dwindling sales (and shrinking subsidies) and the ever-greater pressure on scholars to publish. In this article, the…

  13. Research Writing and NNSs: From the Editors.

    ERIC Educational Resources Information Center

    Gosden, Hugh

    1992-01-01

    Varied linguistic and sociopragmatic skills required for effective international research reporting are discussed based on a survey of journal editors in North America and the United Kingdom. Emphasis is on language-related criteria that influence publication decisions, and suggestions are offered for teaching research writing. (17 references)…

  14. OPM Scheme Editor 2: A graphical editor for specifying object-protocol structures

    SciTech Connect

    Chen, I-Min A.; Markowitz, V.M.; Pang, F.; Ben-Shachar, O.

    1993-07-01

    This document describes an X-window based Schema Editor for the Object-Protocol Model (OPM). OPM is a data model that supports the specification of complex object and protocol classes. objects and protocols are qualified in OPM by attributes that are defined over (associated with) value classes. Connections of object and protocol classes are expressed in OPM via attributes. OPM supports the specification (expansion) of protocols in terms of alternative and sequences of component (sub) protocols. The OPM Schema Editor allows specifying, displaying, modifying, and browsing through OPM schemas. The OPM Schema Editor generates an output file that can be used as input to an OPM schema translation tool that maps OPM schemas into definitions for relational database management systems. The OPM Schema Editor was implemented using C++ and the X11 based Motif toolkit, on Sun SPARCstation under Sun Unix OS 4.1. This document consists of the following parts: (1) A tutorial consisting of seven introductory lessons for the OPM Schema Editor. (2) A reference manual describing all the windows and functions of the OPM Schema Editor. (3) An appendix with an overview of OPM.

  15. Advice for a young editor: the scientific publication.

    PubMed

    Turpin, David L

    2005-01-01

    Being the editor of a scientific journal involves the same challenges of working with authors, association officers, and readers as in all publications. In addition to the communication in the journal, editors must manage the communication about the journal. The editor's job involves building and maintaining trust.

  16. Editor and Student Views on the Censorship Game.

    ERIC Educational Resources Information Center

    Raburn, Josephine

    Out of 200 newspaper editors randomly selected from a directory, 64 responded to a questionnaire eliciting their opinions on the subject materials most often censored by groups in the United States. The editors' responses were compared to those of 121 freshmen at Cameron University (Oklahoma). A majority of the editors supported the First…

  17. Evolutionary theory in letters to the editor.

    PubMed

    Silva, Eric Orion; Lowe, Clayton Cory

    2015-05-01

    This research note presents the results of a content analysis of 234 letters to the editors that discuss evolutionary theory and were published in American newspapers. We find that letters to the editor both support and hinder the cause of teaching evolutionary theory in American secondary schools. On the one hand, anti-evolutionary theory messages are marginalized in the letters section. This marginalization signals a low level of legitimacy for creationism. It might also contribute to the sense of tension that sustains creationist identities. On the other hand, relatively few letters explicitly note the fact that scientists or the scientific community accept evolution. Interestingly, the obscuration of the scientific community's support for evolutionary theory occurs both in letters supporting and opposing evolutionary theory.

  18. Unified Meta-Component Model Specification Editor

    DTIC Science & Technology

    2004-04-20

    relationship between the two major user interface modules, the editor and wizard, and their associated features. Functional to module mapping diagrams are...SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as Report (SAR) 18 . NUMBER OF PAGES 148 19a. NAME OF RESPONSIBLE...PERSON a. REPORT unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39- 18

  19. Workbench surface editor of brain cortical surface

    NASA Astrophysics Data System (ADS)

    Dow, Douglas E.; Nowinski, Wieslaw L.; Serra, Luis

    1996-04-01

    We have developed a 3D reach-in tool to manually reconstruct 3D cortical surface patches from 2D brain atlas images. The first application of our cortex editor is building 3D functional maps, specifically Brodmann's areas. This tool may also be useful in clinical practice to adjust incorrectly mapped atlas regions due to the deforming effect of lesions. The cortex editor allows a domain expert to control the correlation of control points across slices. Correct correlation has been difficult for 3D reconstruction algorithms because the atlas slices are far apart and because of the complex topology of the cortex which differs so much from slice to slice. Also, higher precision of the resulting surfaces is demanded since these define 3D brain atlas features upon which future stereotactic surgery may be based. The cortex editor described in this paper provides a tool suitable for a domain expert to use in defining the 3D surface of a Brodmann's area.

  20. In silico modification of Zn2+ binding group of suberoylanilide hydroxamic acid (SAHA) by organoselenium compounds as Homo sapiens class II HDAC inhibitor of cervical cancer

    NASA Astrophysics Data System (ADS)

    Sumo Friend Tambunan, Usman; Bakri, Ridla; Aditya Parikesit, Arli; Ariyani, Titin; Dyah Puspitasari, Ratih; Kerami, Djati

    2016-02-01

    Cervical cancer is the most common cancer in women, and ranks seventh of all cancers worldwide, with 529000 cases in 2008 and more than 85% cases occur in developing countries. One way to treat this cancer is through the inhibition of HDAC enzymes which play a strategic role in the regulation of gene expression. Suberoyl Anilide Hydroxamic Acid (SAHA) or Vorinostat is a drug which commercially available to treat the cancer, but still has some side effects. This research present in silico SAHA modification in Zinc Binding Group (ZBG) by organoselenium compound to get ligands which less side effect. From molecular docking simulation, and interaction analysis, there are five best ligands, namely CC27, HA27, HB28, IB25, and KA7. These five ligands have better binding affinity than the standards, and also have interaction with Zn2+ cofactor of inhibited HDAC enzymes. This research is expected to produce more potent HDAC inhibitor as novel drug for cervical cancer treatment.

  1. New “Editor's choice”: Online journals debut

    NASA Astrophysics Data System (ADS)

    Cole, Stephen

    With all AGU journal articles now published online in advance of the printed journal, AGU members have new options, in terms of how they access the latest research results. An innovative option for those with specific research interests that are covered in several journals is the " Editor's Choice" virtual journal. The first two "Editor's Choice" journals—Biogeosciences and Atmospheric Electricity— debuted in January and are, for a limited time, freely accessible to members on the AGU Web site.An "Editor's Choice" virtual journal is a collection of electronic articles recently published by AGU that have been specially selected for their relevance to a particular topic area. Everett Shock of Washington University St. Louis, is serving as the Collection Editor for "Editor's Choice: Biogeosciences." The "Editor's Choice: Atmospheric Electricity" Collection Editor is Richard E. Orville of Texas A&M University College Station, who is being assisted by advisors David Sentman, University of Alaska, and Vladimir Rakov, University of Florida.

  2. Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines.

    PubMed

    Lillehammer, Trine; Engesaeter, Birgit O; Prasmickaite, Lina; Maelandsmo, Gunhild M; Fodstad, Oystein; Engebraaten, Olav

    2007-06-01

    Currently, dacarbazine (DTIC) is the only approved systemic treatment for metastatic malignant melanoma. However, the modest treatment effect encourages studies on novel therapeutic molecules, delivery systems and combination therapies. Full-length TRAIL, delivered from an adenoviral vector (Ad-hTRAIL), was studied in combination with DTIC or the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in human melanoma cell lines. The cytotoxic potential of the combination treatments was assessed by cell viability measurements and CalcuSyn analysis. Involvement of apoptosis was analyzed by TUNEL staining, mitochondrial membrane potential measurements, and activation and expression levels of caspases and other mediators of apoptosis. Ad-hTRAIL in combination with DTIC or SAHA resulted in additive or synergistic growth inhibition compared to each treatment used as single agent. Both combinations augmented apoptosis, which was mediated through the death receptor (DR) pathway by enhanced activation of caspase-8, and through increased loss of mitochondrial integrity. Provoked cleavage of Bid, which bridges the extrinsic and intrinsic apoptosis pathways, and downregulation of the anti-apoptotic mediators Bcl-X(L), Mcl-1 and XIAP (but not Bcl-2) were critical contributing factors. Increased levels of DR4 and DR5 were not a common underlying mechanism as DTIC did not affect the levels of either of the receptors. However, SAHA-induced expression of DR4 may have reduced the TRAIL resistance in the SKMEL-28 cell line. Administration of Ad-hTRAIL in combination with DTIC or SAHA enhances apoptosis in human melanoma cell lines, and suggests that the therapeutic potential of such treatment strategies should be further evaluated for possible clinical use.

  3. The anti-tumor histone deacetylase inhibitor SAHA and the natural flavonoid curcumin exhibit synergistic neuroprotection against amyloid-beta toxicity.

    PubMed

    Meng, Jia; Li, Yan; Camarillo, Cynthia; Yao, Yue; Zhang, Yina; Xu, Chun; Jiang, Lihong

    2014-01-01

    With the trend of an increasing aged population worldwide, Alzheimer's disease (AD), an age-related neurodegenerative disorder, as one of the major causes of dementia in elderly people is of growing concern. Despite the many hard efforts attempted during the past several decades in trying to elucidate the pathological mechanisms underlying AD and putting forward potential therapeutic strategies, there is still a lack of effective treatments for AD. The efficacy of many potential therapeutic drugs for AD is of main concern in clinical practice. For example, large bodies of evidence show that the anti-tumor histone deacetylase (HDAC) inhibitor, suberoylanilidehydroxamic acid (SAHA), may be of benefit for the treatment of AD; however, its extensive inhibition of HDACs makes it a poor therapeutic. Moreover, the natural flavonoid, curcumin, may also have a potential therapeutic benefit against AD; however, it is plagued by low bioavailability. Therefore, the integrative effects of SAHA and curcumin were investigated as a protection against amyloid-beta neurotoxicity in vitro. We hypothesized that at low doses their synergistic effect would improve therapeutic selectivity, based on experiments that showed that at low concentrations SAHA and curcumin could provide comprehensive protection against Aβ25-35-induced neuronal damage in PC12 cells, strongly implying potent synergism. Furthermore, network analysis suggested that the possible mechanism underlying their synergistic action might be derived from restoration of the damaged functional link between Akt and the CBP/p300 pathway, which plays a crucial role in the pathological development of AD. Thus, our findings provided a feasible avenue for the application of a synergistic drug combination, SAHA and curcumin, in the treatment of AD.

  4. Effects of Treatment with Suppressive Combination Antiretroviral Drug Therapy and the Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid; (SAHA) on SIV-Infected Chinese Rhesus Macaques

    PubMed Central

    Ling, Binhua; Piatak, Michael; Rogers, Linda; Johnson, Ann-Marie; Russell-Lodrigue, Kasi; Hazuda, Daria J.; Lifson, Jeffrey D.; Veazey, Ronald S.

    2014-01-01

    Objectives Viral reservoirs–persistent residual virus despite combination antiretroviral therapy (cART)–remain an obstacle to cure of HIV-1 infection. Difficulty studying reservoirs in patients underscores the need for animal models that mimics HIV infected humans on cART. We studied SIV-infected Chinese-origin rhesus macaques (Ch-RM) treated with intensive combination antiretroviral therapy (cART) and 3 weeks of treatment with the histone deacetyalse inhibitor, suberoylanilide hydroxamic acid (SAHA). Methods SIVmac251 infected Ch-RM received reverse transcriptase inhibitors PMPA and FTC and integrase inhibitor L-870812 beginning 7 weeks post infection. Integrase inhibitor L-900564 and boosted protease inhibitor treatment with Darunavir and Ritonavir were added later. cART was continued for 45 weeks, with daily SAHA administered for the last 3 weeks, followed by euthanasia/necropsy. Plasma viral RNA and cell/tissue-associated SIV gag RNA and DNA were quantified by qRT-PCR/qPCR, with flow cytometry monitoring changes in immune cell populations. Results Upon cART initiation, plasma viremia declined, remaining <30 SIV RNA copy Eq/ml during cART, with occasional blips. Decreased viral replication was associated with decreased immune activation and partial restoration of intestinal CD4+ T cells. SAHA was well tolerated but did not result in demonstrable treatment-associated changes in plasma or cell associated viral parameters. Conclusions The ability to achieve and sustain virological suppression makes cART-suppressed, SIV-infected Ch-RM a potentially useful model to evaluate interventions targeting residual virus. However, despite intensive cART over one year, persistent viral DNA and RNA remained in tissues of all three animals. While well tolerated, three weeks of SAHA treatment did not demonstrably impact viral RNA levels in plasma or tissues; perhaps reflecting dosing, sampling and assay limitations. PMID:25033210

  5. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.

    PubMed

    Komatsu, Seiichiro; Moriya, Shota; Che, Xiao-Fang; Yokoyama, Tomohisa; Kohno, Norio; Miyazawa, Keisuke

    2013-07-19

    The ubiquitin-proteasome pathway and the autophagy-lysosome pathway are two major intracellular protein degradation systems. We previously reported that clarithromycin (CAM) blocks autophagy flux, and that combined treatment with CAM and proteasome inhibitor bortezomib (BZ) enhances ER-stress-mediated apoptosis in breast cancer cells, whereas treatment with CAM alone results in almost no cytotoxicity. Since HDAC6 is involved in aggresome formation, which is recognized as a cytoprotective response serving to sequester misfolded proteins and facilitate their clearance by autophagy, we further investigated the combined effect of vorinostat (suberoylanilide hydroxamic acid (SAHA)), which has a potent inhibitory effect for HDAC6, with CAM and BZ in breast cancer cell lines. SAHA exhibited some cytotoxicity along with an increased acetylation level of α-tubulin, a substrate of HDAC6. Combined treatment of SAHA, CAM, and BZ potently enhanced the apoptosis-inducing effect compared with treatment using each reagent alone or a combination of two of the three. Expression levels of ER-stress-related genes, including the pro-apoptotic transcription factor CHOP (GADD153), were maximally induced by the simultaneous combination of three reagents. Like breast cancer cell lines, a wild-type murine embryonic fibroblast (MEF) cell line exhibited enhanced cytotoxicity and maximally up-regulated Chop after combined treatment with SAHA, CAM, and BZ; however, a Chop knockout MEF cell line almost completely canceled this enhanced effect. The specific HDAC6 inhibitor tubacin also exhibited a pronounced cytocidal effect with a combination of CAM plus BZ. These data suggest that simultaneous targeting of intracellular proteolytic pathways and HDAC6 enhances ER-stress-mediated apoptosis in breast cancer cells. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Nonuniqueness of two-temperature Guldberg-Waage and Saha equations: Influence on thermophysical properties of SF{sub 6} plasmas

    SciTech Connect

    Wang, Weizong; Rong, Mingzhe; Spencer, Joseph W.

    2013-11-15

    This paper focuses to study how the choice of Guldberg-Waage and Saha equations affects the thermodynamic properties and transport coefficients of SF{sub 6} plasmas under both thermal equilibrium and non-equilibrium conditions. The species composition is numerically determined using two typical forms of two-temperature Saha equations and Guldberg-Waage equations that have appeared in the literature. The great influence of the choice of the excitation temperature on the plasma composition and hence the thermodynamic properties and transport coefficients is discussed as well. Transport coefficients are calculated with most recent collision interaction potentials by adopting Devoto's electron and heavy particle decoupling approach but expanded to the third-order approximation (second-order for viscosity) within the framework of Chapman-Enskog method. Furthermore, an analysis of the effect of different definitions of Debye length on the properties values was performed as well. The results are computed for various values of pressures from 0.10 atm to 10 atm and non-equilibrium parameter, i.e., ratio of the electron temperature to the heavy particle temperature from 1 to 5 with electron temperature range from 300 to 40 000 K. Both forms of Guldberg-Waage and Saha equations used here can give completely the same value when the two-temperature model reaches the special case of local thermodynamic equilibrium. It has been observed that all above mentioned factors can significantly modify the plasma species composition and consequently affect the thermodynamic and transport properties.

  7. SAHA treatment overcomes the anti-apoptotic effects of Bcl-2 and is associated with the formation of mature PML nuclear bodies in human leukemic U937 cells.

    PubMed

    Lee, Jee Suk; Jeong, Seung Hun; Soung, Young Hwa; Kim, Tae Hyun; Choi, Hong Jo; Park, Bong Soo; Kwon, Taeg Kyu; Yoo, Young Hyun

    2009-09-14

    Bcl-2 protects tumor cells from the apoptotic effects of various antineoplastic agents. Increased expression of Bcl-2 has been associated with poor response to chemotherapy in various malignancies, including leukemia. Therefore, bypassing the resistance conferred by anti-apoptotic factors such as Bcl-2 represents an attractive therapeutic strategy against cancer cells, including leukemic cells. We undertook this study to examine whether SAHA (suberoylanilide hydroxamic acid) overcomes the resistance by Bcl-2 in human leukemic cells, with a specific focus on the involvement of PML-NBs. Experiments were conducted with Bcl-2-overexpressing human leukemic U937 cells. Since we previously demonstrated that overexpression of Bcl-2 attenuates resveratrol-induced apoptosis in human leukemic U937 cells, resveratrol-treated U937 cells were used as a negative control. The present study indicates that SAHA at 1-7 microM, the dose range known to induce apoptosis in various cancer cells, overcomes the anti-apoptotic effects of Bcl-2 in Bcl-2-overexpressing human leukemic U937 cells. Notably, we observed that SAHA-induced formation of mature promyelocytic leukemia (PML) nuclear bodies (NBs) correlates with overcoming the anti-apoptotic effects of Bcl-2 in human leukemic U937 cells. Thus, PML protein and the formation of mature PML-NBs could be considered as therapeutic targets that could help bypass the resistance to apoptosis conferred by Bcl-2. Elucidating exactly how PML regulates Bcl-2 will require further work.

  8. The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells.

    PubMed

    Kerl, Kornelius; Ries, David; Unland, Rebecca; Borchert, Christiane; Moreno, Natalia; Hasselblatt, Martin; Jürgens, Heribert; Kool, Marcel; Görlich, Dennis; Eveslage, Maria; Jung, Manfred; Meisterernst, Michael; Frühwald, Michael

    2013-06-13

    Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were used to identify synergism of the HDAC (histone deacetylase) inhibitor SAHA with fenretinide, tamoxifen and doxorubicin in rhabdoidtumor cell lines. HDAC1 and HDAC2 are overexpressed in primary rhabdoid tumors and rhabdoid tumor cell lines. Targeting HDACs in rhabdoid tumors induces cell cycle arrest and apoptosis. On the other hand HDAC inhibition induces deregulated gene programs (MYCC-, RB program and the stem cell program) in rhabdoid tumors. These programs are in general associated with cell cycle progression. Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis. Furthermore, HDAC inhibition sensitizes rhabdoid tumor cell lines to cell death induced by chemotherapy. Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors.

  9. Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA.

    PubMed

    Klase, Zachary; Yedavalli, Venkat S R K; Houzet, Laurent; Perkins, Molly; Maldarelli, Frank; Brenchley, Jason; Strebel, Klaus; Liu, Paul; Jeang, Kuan-Teh

    2014-03-01

    A major barrier to the elimination of HIV-1 infection is the presence of a pool of long-lived, latently infected CD4+ memory T-cells. The search for treatments to re-activate latent HIV to aid in clearance is hindered by the incomplete understanding of the mechanisms that lead to transcriptional silencing of viral gene expression in host cells. Here we identify a previously unknown role for RUNX1 in HIV-1 transcriptional latency. The RUNX proteins, in combination with the co-factor CBF-β, are critical transcriptional regulators in T-cells. RUNX1 strongly modulates CD4 expression and contributes to CD4+ T-cell function. We show that RUNX1 can bind DNA sequences within the HIV-1 LTR and that this binding represses transcription. Using patient samples we show a negative correlation between RUNX1 expression and viral load. Furthermore, we find that pharmacologic inhibition of RUNX1 by a small molecule inhibitor, Ro5-3335, synergizes with the histone deacetylase (HDAC) inhibitor SAHA (Vorinostat) to enhance the activation of latent HIV-1 in both cell lines and PBMCs from patients. Our findings indicate that RUNX1 and CBF-β cooperate in cells to modulate HIV-1 replication, identifying for the first time RUNX1 as a cellular factor involved in HIV-1 latency. This work highlights the therapeutic potential of inhibitors of RUNX1 to re-activate virus and aid in clearance of HIV-1.

  10. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-04-01

    From the Board of Editors: on Plagiarism

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur

  11. Meet the Editor: Global Biogeochemical Cycles

    NASA Astrophysics Data System (ADS)

    Kumar, Mohi

    Meinrat Andreae was named the editor of the AGU's journal Global Biogeochemical Cycles last year.Andreae, director of the biogeochemistry department at the Max Plank Institute for Chemistry (MPIC), located in Mainz, Germany said that he plans to maintain the journal as a resource that highlights the broad spectrum of interdisciplinary themes that showcase the interactions between the biosphere and the geosphere. “Our special niche is in the field of larger-scale, more integrative studies that have global scope,” he explained.

  12. MPS Editor - An Integrated Sequencing Environment

    NASA Technical Reports Server (NTRS)

    Streiffert, Barbara A.; O'Reilly, Taifun; Schrock, Mitchell; Catchen, Jaime

    2010-01-01

    In today's operations environment, the teams are smaller and need to be more efficient while still ensuring the safety and success of the mission. In addition, teams often begin working on a mission in its early development phases and continue on the team through actual operations. For these reasons the operations teams want to be presented with a software environment that integrates multiple needed software applications as well as providing them with context sensitive editing support for entering commands and sequences of commands. At Jet Propulsion Laboratory, the Multi-Mission Planning and Sequencing (MPS) Editor provided by the Multi-Mission Ground Systems and Services (MGSS) supports those operational needs.

  13. MPS Editor - An Integrated Sequencing Environment

    NASA Technical Reports Server (NTRS)

    Streiffert, Barbara A.; O'Reilly, Taifun; Schrock, Mitchell; Catchen, Jaime

    2010-01-01

    In today's operations environment, the teams are smaller and need to be more efficient while still ensuring the safety and success of the mission. In addition, teams often begin working on a mission in its early development phases and continue on the team through actual operations. For these reasons the operations teams want to be presented with a software environment that integrates multiple needed software applications as well as providing them with context sensitive editing support for entering commands and sequences of commands. At Jet Propulsion Laboratory, the Multi-Mission Planning and Sequencing (MPS) Editor provided by the Multi-Mission Ground Systems and Services (MGSS) supports those operational needs.

  14. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-03-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially similar scientific content

  15. A Tisket, A Tasket--Out of the Editor's Basket

    NASA Astrophysics Data System (ADS)

    Williams, Kathryn R.

    2001-05-01

    In September 1940, the Journal introduced Out of the Editor's Basket for short items of interest: excerpts from letters, pamphlets, newspapers, and periodicals. By 1950, however, the Editor's Basket had evolved into a bulletin board for descriptions of new products and services, and it now contains almost exclusively press releases about recently marketed items. Now over 60 years old, the Editor's Basket still provides interesting tidbits for the Journal's broad readership.

  16. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-05-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially

  17. From the Board of Editors: on Plagiarism

    NASA Astrophysics Data System (ADS)

    2005-04-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially

  18. Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model.

    PubMed

    Zhu, Zongjian; Jiang, Weiqin; McGinley, John N; Thompson, Henry J

    2013-04-01

    Dietary energy restriction (DER) inhibits experimentally induced mammary cancer, an effect accompanied by elevated levels of silent information regulator 2 (SIRT1), a class III histone deacetylase (HDAC). However, the effect of DER on targets of other classes of HDACs has not been reported, a highly relevant issue given evidence that HDAC induction favors the development of cancer and tumor growth. Experiments were carried out to determine whether suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor with broad activity, would affect the anti-cancer activity of DER. Female Sprague Dawley rats (n = 30/group) were injected with 1-methyl-1-nitrosourea (50 mg/kg) at 21 days of age and 7 days thereafter were randomized to groups fed: (i) control diet (AIN-93G), (ii) 0.1% SAHA (w/w), (iii) 40% DER, or (iv) 0.1% SAHA + 40% DER. An additional group was fed 0.1% SAHA + 40%DER for 5 weeks and released to control diet for 3 weeks. DER significantly reduced mammary cancer incidence, multiplicity, and cancer burden and prolonged cancer latency (P < 0.01). Cancer inhibition was maintained in SAHA + DER, despite evidence that histone (H2A(Lys9), H2B(Lys5), and H4(Lys5/8/12/16), but not H3(Lys9); P < 0.001) and non-histone protein deacetylation (p53(Lys373) and p53(Lys382); P < 0.001) induced by DER was reversed by SAHA. This indicates that the inhibition of DER of cancer is not dependent on HDAC induction. After releasing rats from DER + SAHA, cancer multiplicity remained lower than control (P < 0.05), consistent with apoptosis-mediated cell deletion. These findings support further investigation of the hypothesis that HDAC induction by DER blunts its anti-carcinogenic impact.

  19. Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques.

    PubMed

    Del Prete, Gregory Q; Shoemaker, Rebecca; Oswald, Kelli; Lara, Abigail; Trubey, Charles M; Fast, Randy; Schneider, Douglas K; Kiser, Rebecca; Coalter, Vicky; Wiles, Adam; Wiles, Rodney; Freemire, Brandi; Keele, Brandon F; Estes, Jacob D; Quiñones, Octavio A; Smedley, Jeremy; Macallister, Rhonda; Sanchez, Rosa I; Wai, John S; Tan, Christopher M; Alvord, W Gregory; Hazuda, Daria J; Piatak, Michael; Lifson, Jeffrey D

    2014-11-01

    Nonhuman primate models are needed for evaluations of proposed strategies targeting residual virus that persists in HIV-1-infected individuals receiving suppressive combination antiretroviral therapy (cART). However, relevant nonhuman primate (NHP) models of cART-mediated suppression have proven challenging to develop. We used a novel three-class, six-drug cART regimen to achieve durable 4.0- to 5.5-log reductions in plasma viremia levels and declines in cell-associated viral RNA and DNA in blood and tissues of simian immunodeficiency virus SIVmac239-infected Indian-origin rhesus macaques, then evaluated the impact of treatment with the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA; Vorinostat) on the residual virus pool. Ex vivo SAHA treatment of CD4(+) T cells obtained from cART-suppressed animals increased histone acetylation and viral RNA levels in culture supernatants. cART-suppressed animals each received 84 total doses of oral SAHA. We observed SAHA dose-dependent increases in acetylated histones with evidence for sustained modulation as well as refractoriness following prolonged administration. In vivo virologic activity was demonstrated based on the ratio of viral RNA to viral DNA in peripheral blood mononuclear cells, a presumptive measure of viral transcription, which significantly increased in SAHA-treated animals. However, residual virus was readily detected at the end of treatment, suggesting that SAHA alone may be insufficient for viral eradication in the setting of suppressive cART. The effects observed were similar to emerging data for repeat-dose SAHA treatment of HIV-infected individuals on cART, demonstrating the feasibility, utility, and relevance of NHP models of cART-mediated suppression for in vivo assessments of AIDS virus functional cure/eradication approaches.

  20. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Lidström, Suzanne

    2012-04-01

    When Professor Anders Bárány took over as the Executive Editor of Physica Scripta, in 1986, he talked of his trepidation at having to 'dress himself' in his predecessor's 'editorial coveralls'. At that time, they had been worn by Professor Nils Robert Nilsson, a major figure in the physics community, for almost 20 years. Just one year prior to this, Professor Roger Wäppling had been recruited to the position of Subeditor in conjunction with a decision to expand the number of contributions in the field of condensed matter physics, to turn it into one of the dominant subjects in the broad-based journal. Physica Scripta had already gained a reputation for being a high quality journal with wide coverage of both experimental and theoretical physics. Interestingly, in the mid 1980s, the number of papers submitted had been growing and an impressive 250 submissions per year had been attained, with all of the manuscripts being handled in-house. Not many miles away in the town of Uppsala, a group of English students was stepping off a train on a magnificent snowy day in January to embark on their final year projects. A couple of us enjoyed ourselves so much that we stayed on afterwards as PhD students, thereby encountering the mixed pleasure of studying physics in a second language for the first time. I used to copy the notes down meticulously in Swedish, then try to work backwards with a textbook to improve my language skills. One day, returning from a particularly incomprehensible lecture on solid state physics, I showed my roommates my notes and asked if they could please explain what the lecture had been about: 'I don't know', they replied, 'but this bit is about sheep!' Meanwhile, back at Physica Scripta, the journal continued to flourish: 400 submissions were received in 1996, and the march of progress was well underway. Manuscripts could now be sent in on disks and Physica Scripta was available on the World Wide Web. Roger was appointed to manage the journal and

  1. John F. Dewey—Tectonics Editor

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    ‘I want the journal to acquire a reputation for very rapid, fair, and accurate reviewing,’ asserted John F. Dewey, editor-in-chief of AGU's newest journal, Tectonics. Dewey said that he will rule the bimonthly, which will begin publication in February, ‘with a bit of a rod of iron’ to ensure that Tectonics is ‘where only original and important papers are published.’‘I'm going to be very strict with reviewers,’ Dewey explained in his quick British clip. ‘If the review does not come back to me within 10 days to 2 weeks, I'll review the paper myself. I'm also going to have a system whereby, if a paper needs major surgery after being refereed, it will be rejected. Papers will have to be in virtually publishable condition before they are first submitted,’ he said.

  2. A former Editor views the editorial process

    NASA Astrophysics Data System (ADS)

    Freeze, R. Allan

    It was at the AGU Fall Meeting in San Francisco in December 1976, shortly after my appointment as coeditor of Water Resources Research that I first began to realize the strong emotional ties that exist between a scientific community and its journals. Feelings run high, regardless of whether they come from readers, contributors, reviewers, active scientists, or scientific administrators. Opinions are often positive, sometimes negative, usually a mixture of the two; but regardless of their tenor they are delivered to the editor, in person, usually fortissimo. From that day until this, conference life has never been dull. When I meet a colleague in the halls there is never a loss for words, no need to search for a topic of mutual interest; WRR is always there at the ready.

  3. Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics.

    PubMed

    Zhou, Xiaoling; Yang, Xu-Yu; Popescu, Nicholas C

    2010-04-01

    Inactivation of tumor suppressor genes is a major contributing alteration in the initiation or progression of cancer. The human tumor suppressor gene DLC1 (deleted in liver cancer 1) is frequently downregulated or silenced in multiple cancers, predominantly by epigenetic mechanisms. With the current considerable interest and progress in epigenetic therapy, a number of promising antineoplastic agents, particularly histone deacetylase (HDAC) inhibitors, have been developed and used successfully in clinical trials. Both DLC1 and HDAC inhibitors exert antineoplastic functions, and their combined action could be exploited for a more effective cancer therapy. To evaluate the potential benefits of this approach, we examined the antineoplastic effects of adenoviral (Ad)-DLC1-mediated transduction and exposure to suberoylanilide hydroxamic acid (SAHA), a powerful HDAC inhibitor, in two human cancer cell lines that lack intrinsic DLC1 expression, 22Rv1 prostate cancer cells and 7703K human hepatocellular carcinoma cells. Consistent with the oncosuppressive function of DLC1 in several cancers, including prostate and liver cancer, transduction of 22Rv1 and 7703K cells with an Ad-DLC1 expression vector resulted in alterations of cell morphology, induction of apoptosis, and inhibition of cell proliferation, migration, and anchorage-independent growth. A low concentration of SAHA (5 microM) efficiently restored the expression of DLC1 in 22Rv1 cells that lack DLC1 expression due to histone deacetylation but had a minimal effect in 7703K cells in which silencing of the DLC1 gene is due mainly to promoter hypermethylation. Regardless of the epigenetic mechanism of DLC1 inactivation, SAHA treatment of DLC1-transduced cells had a synergistic inhibitory effect on tumor cell proliferation and tumorigenesis in both cell lines. In 22Rv1 cells, this combination regimen nearly abolished the formation of colonies in semisolid media as a measure of tumorigenicity in vitro. Current in vitro

  4. Generating the Field: The Role of Editors in Disciplinary Formation

    ERIC Educational Resources Information Center

    Selfe, Cynthia; Villanueva, Victor; Parks, Steve

    2017-01-01

    In the following conversation, conducted asynchronously through email, three current and former editors discuss the role of publishing in creating a disciplinary identity. Speaking from the academic (Villanueva), digital (Selfe), and community (Parks), and, often crossing these three categories, the editors discuss how the field has failed to…

  5. Journal Editor Perceptions of Universities: Some Empirical Evidence

    ERIC Educational Resources Information Center

    Mainardes, Emerson Wagner; Raposo, Mario; Alves, Helena

    2012-01-01

    Out of considerations as to the importance of university relationships with their various stakeholders, the primary objective of this research project was to identify the perceptions of academic journal editors regarding universities. Editors were asked to provide their perceptions on: (a) the relevance of universities to academic publications;…

  6. Peer reviews and the role of a journal editor

    USDA-ARS?s Scientific Manuscript database

    Obtaining peer reviews for manuscripts submitted to scientific journals is becoming increasingly difficult. Changes to the system are necessary, and editors must cultivate and maintain a solid base of reviewers to help evaluate journal submissions. This article outlines some steps editors can and sh...

  7. A graphic editor for analyzing signal-transduction pathways.

    PubMed

    Koike, T; Rzhetsky, A

    2000-12-23

    We describe a graphical editor designed specifically to facilitate analysis and visualization of complex signal-transduction pathways. The editor provides automatic layout of complex regulatory graphs and enables users easily to maintain, edit, and exchange publication-quality images of regulatory networks.

  8. The RAE and Publications: A Review of Journal Editors.

    ERIC Educational Resources Information Center

    Talib, Ameen Ali

    2000-01-01

    Surveyed editors of academic journals about publication issues related to Britain's Research Assessment Exercise (RAE), a process of grading and funding universities based on published research output. Editors were asked about research quality and output, publication practices, academics' willingness to referee manuscripts, and proliferation of…

  9. How Newspaper Editors Reacted to "Post's" Pulitzer Prize Hoax.

    ERIC Educational Resources Information Center

    Anderson, Douglas A.

    1982-01-01

    Reports the findings of a nationwide survey of newspaper editors, revealing that most thought that the Janet Cooke hoax had been poorly handled by the "Washington Post." Notes that most of the editors said their newspapers had systems of review for stories coming from anonymous sources. (FL)

  10. The RAE and Publications: A Review of Journal Editors.

    ERIC Educational Resources Information Center

    Talib, Ameen Ali

    2000-01-01

    Surveyed editors of academic journals about publication issues related to Britain's Research Assessment Exercise (RAE), a process of grading and funding universities based on published research output. Editors were asked about research quality and output, publication practices, academics' willingness to referee manuscripts, and proliferation of…

  11. March 2017 Letters to the Editor-in-Chief.

    PubMed

    2017-03-01

    Letters to the Editor-in-Chief of JOSPT as follows: "Regarding 'Unraveling the Complexity of Low Back Pain'" with Authors' Response "Beall's List Has Vanished: What Next?" with Editor-in-Chief Response J Orthop Sports Phys Ther 2017;47(3):219-223. doi:10.2519/jospt.2017.0202.

  12. JSME: a free molecule editor in JavaScript.

    PubMed

    Bienfait, Bruno; Ertl, Peter

    2013-01-01

    A molecule editor, i.e. a program facilitating graphical input and interactive editing of molecules, is an indispensable part of every cheminformatics or molecular processing system. Today, when a web browser has become the universal scientific user interface, a tool to edit molecules directly within the web browser is essential. One of the most popular tools for molecular structure input on the web is the JME applet. Since its release nearly 15 years ago, however the web environment has changed and Java applets are facing increasing implementation hurdles due to their maintenance and support requirements, as well as security issues. This prompted us to update the JME editor and port it to a modern Internet programming language - JavaScript. The actual molecule editing Java code of the JME editor was translated into JavaScript with help of the Google Web Toolkit compiler and a custom library that emulates a subset of the GUI features of the Java runtime environment. In this process, the editor was enhanced by additional functionalities including a substituent menu, copy/paste, drag and drop and undo/redo capabilities and an integrated help. In addition to desktop computers, the editor supports molecule editing on touch devices, including iPhone, iPad and Android phones and tablets. In analogy to JME the new editor is named JSME. This new molecule editor is compact, easy to use and easy to incorporate into web pages. A free molecule editor written in JavaScript was developed and is released under the terms of permissive BSD license. The editor is compatible with JME, has practically the same user interface as well as the web application programming interface. The JSME editor is available for download from the project web page http://peter-ertl.com/jsme/

  13. JSME: a free molecule editor in JavaScript

    PubMed Central

    2013-01-01

    Background A molecule editor, i.e. a program facilitating graphical input and interactive editing of molecules, is an indispensable part of every cheminformatics or molecular processing system. Today, when a web browser has become the universal scientific user interface, a tool to edit molecules directly within the web browser is essential. One of the most popular tools for molecular structure input on the web is the JME applet. Since its release nearly 15 years ago, however the web environment has changed and Java applets are facing increasing implementation hurdles due to their maintenance and support requirements, as well as security issues. This prompted us to update the JME editor and port it to a modern Internet programming language - JavaScript. Summary The actual molecule editing Java code of the JME editor was translated into JavaScript with help of the Google Web Toolkit compiler and a custom library that emulates a subset of the GUI features of the Java runtime environment. In this process, the editor was enhanced by additional functionalities including a substituent menu, copy/paste, drag and drop and undo/redo capabilities and an integrated help. In addition to desktop computers, the editor supports molecule editing on touch devices, including iPhone, iPad and Android phones and tablets. In analogy to JME the new editor is named JSME. This new molecule editor is compact, easy to use and easy to incorporate into web pages. Conclusions A free molecule editor written in JavaScript was developed and is released under the terms of permissive BSD license. The editor is compatible with JME, has practically the same user interface as well as the web application programming interface. The JSME editor is available for download from the project web page http://peter-ertl.com/jsme/ PMID:23694746

  14. Representation of women as editors in the Cochrane collaboration.

    PubMed

    Bhaumik, Soumyadeep; Mathew, Rebecca Joyce

    2014-12-01

    There is considerable gender disparity in editorial boards of medical journals. Being an editor in a Cochrane review group (CRG), like being an editor in a medical journal, is an indirect representation of one's reputation and leadership abilities in a particular specialty. The aim of the study was to analyze the representation of women editors on the editorial teams of CRG's and the Central Editorial Unit (CEU) of the Cochrane Collaboration. Information about editorial team members of CRGs and the CEU was extracted from respective websites. Gender of the individual was determined by inspection of names, individual profile description or photographs in the CRG or institutional webpage, social networking sites and internet search. Data was validated by two authors independently and differences sorted by consensus. A total of 788 editors across all CRGs and the CEU with an overall 371 females (47.1%) and 417 (52.9%) males were identified. of the CEU editors, 62.5% were females. There were 68 coordinating editors (35.3% females), and 62 managing editors (56% females), who provided leadership to the CRGs. Eighty-four percent of trial search coordinators were found to be females. Ten CRGs had 75% or more of its editors as females while 7 CRGs had less than or equal to 25% female editors. The representation of women editors in the Cochrane Collaboration was found to be better than in editorial boards of medical journals. There is still scope for improvement to ensure better gender diversity across all roles and in all CRG's. © 2014 Chinese Cochrane Center, West China Hospital of Sichuan University and Wiley Publishing Asia Pty Ltd.

  15. Academic Degradation and the Retreat of the Editors: Academic Irregularities and the Spreading of Academic Corruption from an Editor's Perspective

    ERIC Educational Resources Information Center

    Xun, Gong

    2007-01-01

    Against the backdrop of the grave academic crisis in China, editors have become the objects of wooing, favor-currying, connections-seeking, and collusions; they have been targeted for attacks, plots, extortions, and encroachments. Editing and publishing have become avenues for academic irregularities and academic corruption. Editors have the power…

  16. Academic Degradation and the Retreat of the Editors: Academic Irregularities and the Spreading of Academic Corruption from an Editor's Perspective

    ERIC Educational Resources Information Center

    Xun, Gong

    2007-01-01

    Against the backdrop of the grave academic crisis in China, editors have become the objects of wooing, favor-currying, connections-seeking, and collusions; they have been targeted for attacks, plots, extortions, and encroachments. Editing and publishing have become avenues for academic irregularities and academic corruption. Editors have the power…

  17. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    NASA Astrophysics Data System (ADS)

    Cardona, Manuel

    2005-03-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  18. ESDAPT - APT PROGRAMMING EDITOR AND INTERPRETER

    NASA Technical Reports Server (NTRS)

    Premack, T.

    1994-01-01

    ESDAPT is a graphical programming environment for developing APT (Automatically Programmed Tool) programs for controlling numerically controlled machine tools. ESDAPT has a graphical user interface that provides the user with an APT syntax sensitive text editor and windows for displaying geometry and tool paths. APT geometry statement can also be created using menus and screen picks. ESDAPT interprets APT geometry statements and displays the results in its view windows. Tool paths are generated by batching the APT source to an APT processor (COSMIC P-APT recommended). The tool paths are then displayed in the view windows. Hardcopy output of the view windows is in color PostScript format. ESDAPT is written in C-language, yacc, lex, and XView for use on Sun4 series computers running SunOS. ESDAPT requires 4Mb of disk space, 7Mb of RAM, and MIT's X Window System, Version 11 Release 4, or OpenWindows version 3 for execution. Program documentation in PostScript format and an executable for OpenWindows version 3 are provided on the distribution media. The standard distribution medium for ESDAPT is a .25 inch streaming magnetic tape cartridge (Sun QIC-24) in UNIX tar format. This program was developed in 1992.

  19. Editors' message--Hydrogeology Journal in 2003

    USGS Publications Warehouse

    Voss, Clifford; Olcott, Perry; Schneider, Robert

    2004-01-01

    Hydrogeology Journal appeared in six issues containing a total of 710 pages and 48 major articles, including 31 Papers and 14 Reports, as well as some Technical Notes and Book Reviews. The number of submitted manuscripts continues to increase. The final issue of 2003 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines and authors in 2003 were from about 28 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on a variety of general topics and on studies of hydrogeology in 24 countries: Afghanistan, Algeria, Argentina, Australia, Bangladesh, Belgium, Canada, Chile, China, Denmark, France, India, Italy, Mexico, Netherlands, New Zealand, Nigeria, Norway, Portugal, Russia, South Africa, Switzerland, Turkey, and U.S.A. The Guest Editor of the 2003 HJ theme issue on “Hydromechanics in Geology and Geotechnics”, Ove Stephansson, assembled a valuable collection of technical reviews and research papers from eminent authors on important aspects of the subject area.

  20. Retirement of J. Gary Eden as Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Jagadish, Chennupati; Jelinkova, Helena; Fainman, Yeshaiahu; Dawson, Martin; Ermers, Ysabel

    2016-01-01

    After nine years of dedicated service as Editor-in-Chief of Progress in Quantum Electronics (PQE), J. Gary Eden has retired at the end of December 2015. During his term as the Editor-in-Chief, PQE has grown significantly in size and quality and he has given generously of his time in advising authors, referees, editors, and the journal staff. Gary is an exceptional scientist and a generous individual who has given so much to the community. He is always very positive in every situation, and has created positive environment and supported people with utmost enthusiasm.

  1. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    NASA Astrophysics Data System (ADS)

    Cardona, Manuel

    2005-02-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  2. EDITORIAL: Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Webb, Steve

    2006-01-01

    Physics in Medicine and Biology (PMB) is a journal that originated in the UK but is now rightly regarded as one of the pre-eminent international journals for the publication of material coming within its remit. It is 50 years old and its maturity is an outcome of the consistent support of high performing authors, a supportive and professional publishing house, dedicated referees, many vigorous and conscientious editorial boards and the collective input of the 10 previous Editors as listed in his incoming editorial (January 2000 issue) by the retiring Editor, Professor Alun Beddoe. The scientific climate and it associated publication modus operandi in the 1950s was very different from that at the current time and the journal has evolved to reflect this. Hence today the scope of content is somewhat broader, the size of the journal is vastly greater, the whole publication process is slicker and more efficient and a paper in PMB is highly prized by its authors and those who look to quality factors and impact. The quality of the journal still relies on the voluntary labour and expertise of its busy international referees and Board members. For many years I have tried to place my own research material in PMB and encourage my teams to do likewise, not only acknowledging the prestige of the journal but also because of the extraordinarily fast turnaround time of all the processes without any loss of quality. This serves us very well and the publishing team are to be congratulated. Some things seem to change more slowly or not at all, however. The prediction, when I started my research career, that books and journals would be dinosaurs by now has manifestly not come true and, whilst most of us are addicted (and why not?) to the electronic ways of doing things that can be done by more traditional ways, PMB and a packet of reprints from time to time arriving by post still has a reassuring feel despite the fact that the papers have been `on-line' for a while before. An incoming

  3. Editorial independence and the editor-owner relationship: good editors never die, they just cross the line.

    PubMed

    Lapeña, J F

    2009-12-01

    The concept of editorial freedom or independence is examined in the light of the editor-owner relationship. Like individual and national freedom or independence, it is a rhetorical concept whose realisation flows from internal achievement as much as it depends on external validation. This freedom entails roles and responsibilities embodied in specific codes of practice for editors, such as the guidelines espoused by the International Committee of Medical Journal Editors and the World Association of Medical Editors. The calling to embody these guidelines makes editing a vocation that demands isolation and distancing, separation and solitude. It involves bracketing one's biases, prejudgments and preconceptions. With such detachment comes real freedom; one that requires a moral fibre and trustworthiness that uphold truth and right, whether in full view of public scrutiny, or in the aloneness of private secrecy. The stereotypical tension between academic and commercial concerns highlights the editor-owner relationship, and bears directly on editorial independence. In practice, journal owners overstep their prerogatives. The absence of clear contracts defining editorial independence and the lack of established mechanisms governing the editor-owner relationship affect many small- to medium-sized journals in developing countries. Even large journals in developed and democratic nations or totalitarian states and societies are not spared. At the end of the day, editorial freedom exists only insofar as it is tolerated, or until editors cross the line.

  4. Bibliography or Bust: The "Angst" of Scholarly Editors.

    ERIC Educational Resources Information Center

    Costa, Richard Hauer

    1980-01-01

    Provides evidence indicating not only that the market for articles on literature and language is saturated with submissions, but that the glut creates burgeoning problems for editors, including the problem of rejecting publishable items. (RL)

  5. The Letters Not Sent by a Journal Editor

    NASA Astrophysics Data System (ADS)

    2013-04-01

    In the late hours of the night, even the most conscientious of journal editors may slip into writing imaginary letters to cherished authors and reviewers. Here are some of the letters that I composed:

  6. ANNOUNCEMENT: Greetings from the Editor and Publisher

    NASA Astrophysics Data System (ADS)

    Wäppling, Roger; Williams, Sarah

    2006-01-01

    Physica Scripta is an international physics journal published for the Royal Swedish Academy of Sciences on behalf of the Nordic Science Academies and Physical Societies. This issue marks the beginning of the partnership between the Royal Swedish Academy of Sciences and Institute of Physics Publishing (IOP). We look forward to a fruitful relationship in which Physica Scripta can profit from the international reach of IOP. Authors and readers will benefit from advance publication of articles on the web prior to receiving each month's journal issue. The peer-review system will continue to be managed by Professor Roger Wäppling who will assess each paper before assigning it to an external editor or sending it for refereeing. IOP will receive new article submissions and generate electronic documents suitable for use in the refereeing process. The editorial office in Sweden will then be responsible for these manuscripts up to the final publication decision. Accepted articles will be sent to IOP for copy-editing, typesetting, production and distribution. We aim to provide our authors, referees and readers with an enhanced service for this well-established journal. IOP will maintain and augment Physica Scripta's record in publishing a broad range of high-quality research papers and we will continue to publish Topical Issues as supplements to the regular 12 issues. The popular Comments articles will continue to be published in conjunction with regular papers under this new partnership. We hope that our subscribers will continue to enjoy reading Physica Scripta as a valuable resource for general physics research.

  7. EDITORIAL: A Message from the Editor

    NASA Astrophysics Data System (ADS)

    Hudson, R. P.

    1981-04-01

    As the new Editor of Metrologia, I welcome this opportunity to greet the readers, to say a few words on hopes and plans, and to make both a plea and promise. The plea arises from a perception that, despite its sixteen years of existence, this journal does not yet enjoy a status of intimate familiarity throughout the world community of physicists. Nevertheless, having been established as a vehicle for disseminating knowledge on all matters metrological, it offers a unique communication and archival resource to those who are active in advancing the science (and the art) of accurate measurement. Therefore I beseech all readers to lose no opportunity to submit their finest metrology research reports and their most penetrating metrological ruminations for publication here and—highly important—to encourage their unaware colleagues to do likewise. And, as a journal cannot flourish which is not fully responsive to the needs of its clientele, my promise is to bend every effort to achieving prompt and careful review of your submissions and rapid publication for those accepted. It is my hope and intention, furthermore, to bring about a measure of increased variety of content through occasional seminal review articles, news of major publications and forthcoming conferences, news of current research and development that should be of major interest to the readership well before the publication of its results; and through the inclusion of short communications on research, letters and topics of wide interest, and comments on articles published. In order to successfully promote these aims, your specific contributions and your suggestions for improvements are enthusiastically solicited. Finally, let me record my gratitude to the distinguished scientists who have agreed to serve for a term on the Editorial Board, to assist me in my task and to labour in the interests of you all. Each member of that Board stands ready to assist the readership on any matter pertaining to

  8. The WebACS - An Accessible Graphical Editor.

    PubMed

    Parker, Stefan; Nussbaum, Gerhard; Pölzer, Stephan

    2017-01-01

    This paper is about the solution to accessibility problems met when implementing a graphical editor, a major challenge being the comprehension of the relationships between graphical components, which needs to be guaranteed for blind and vision impaired users. In the concrete case the HTML5 canvas and Javascript were used. Accessibility was reached by implementing a list view of elements, which also enhances the usability of the editor.

  9. Adapting a thesis to publication style: meeting editors' expectations.

    PubMed

    Johnson, S H

    1996-01-01

    Every year hundreds of thesis reports are completed by graduate students. Many of these end up on nursing journal editors' desks, only to be rejected. What characteristics of a thesis lead to rejection? How can authors develop quality research manuscripts? How can faculty teach graduate students the difference between a thesis and manuscript. This article answers these questions by providing advice from 15 critical care and research journal editors.

  10. Substrate Utilization in the Critically Ill (Letter to the Editor)

    DTIC Science & Technology

    2009-02-01

    pen.sagepub.com/ Nutrition Journal of Parenteral and Enteral http://pen.sagepub.com/content/33/1/111 The online version of this article can be found at: DOI...Published by: http://www.sagepublications.com On behalf of: The American Society for Parenteral & Enteral Nutrition can be found at:Journal of...the Editor Dear Editor, Journal of Parenteral and Enteral Nutrition Volume 33 Number 1 January/February 2009 111 © 2009 American Society for Parenteral

  11. ZED- A LINE EDITOR FOR THE DEC VAX

    NASA Technical Reports Server (NTRS)

    Scott, P. J.

    1994-01-01

    The ZED editor for the DEC VAX is a simple, yet powerful line editor for text, program source code, and non-binary data. Line editors can be superior to screen editors in some cases, such as executing complex multiple or conditional commands, or editing via slow modem lines. ZED excels in the area of text processing by using procedure files. For example, such procedures can reformat a file of addresses or remove all comment lines from a FORTRAN program. In addition to command files, ZED also features versatile search qualifiers, global changes, conditionals, on-line help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. The ZED editor was originally developed at Cambridge University in London and has been continuously enhanced since 1976. Users of the Cambridge implementation have devised such elaborate ZED procedures as chess games, calculators, and programs for evaluating Pi. This implementation of ZED strives to maintain the characteristics of the Cambridge editor. A complete ZED manual is included on the tape. ZED is written entirely in C for either batch or interactive execution on the DEC VAX under VMS 4.X and requires 80,896 bytes of memory. This program was released in 1988 and updated in 1989.

  12. ZED- A LINE EDITOR FOR THE DEC VAX

    NASA Technical Reports Server (NTRS)

    Scott, P. J.

    1994-01-01

    The ZED editor for the DEC VAX is a simple, yet powerful line editor for text, program source code, and non-binary data. Line editors can be superior to screen editors in some cases, such as executing complex multiple or conditional commands, or editing via slow modem lines. ZED excels in the area of text processing by using procedure files. For example, such procedures can reformat a file of addresses or remove all comment lines from a FORTRAN program. In addition to command files, ZED also features versatile search qualifiers, global changes, conditionals, on-line help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. The ZED editor was originally developed at Cambridge University in London and has been continuously enhanced since 1976. Users of the Cambridge implementation have devised such elaborate ZED procedures as chess games, calculators, and programs for evaluating Pi. This implementation of ZED strives to maintain the characteristics of the Cambridge editor. A complete ZED manual is included on the tape. ZED is written entirely in C for either batch or interactive execution on the DEC VAX under VMS 4.X and requires 80,896 bytes of memory. This program was released in 1988 and updated in 1989.

  13. EzEditor: a versatile sequence alignment editor for both rRNA- and protein-coding genes.

    PubMed

    Jeon, Yoon-Seong; Lee, Kihyun; Park, Sang-Cheol; Kim, Bong-Soo; Cho, Yong-Joon; Ha, Sung-Min; Chun, Jongsik

    2014-02-01

    EzEditor is a Java-based molecular sequence editor allowing manipulation of both DNA and protein sequence alignments for phylogenetic analysis. It has multiple features optimized to connect initial computer-generated multiple alignment and subsequent phylogenetic analysis by providing manual editing with reference to biological information specific to the genes under consideration. It provides various functionalities for editing rRNA alignments using secondary structure information. In addition, it supports simultaneous editing of both DNA sequences and their translated protein sequences for protein-coding genes. EzEditor is, to our knowledge, the first sequence editing software designed for both rRNA- and protein-coding genes with the visualization of biologically relevant information and should be useful in molecular phylogenetic studies. EzEditor is based on Java, can be run on all major computer operating systems and is freely available from http://sw.ezbiocloud.net/ezeditor/.

  14. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.

    PubMed

    Min, Ahrum; Im, Seock-Ah; Kim, Debora Keunyoung; Song, Sang-Hyun; Kim, Hee-Jun; Lee, Kyung-Hun; Kim, Tae-Yong; Han, Sae-Won; Oh, Do-Youn; Kim, Tae-You; O'Connor, Mark J; Bang, Yung-Jue

    2015-03-07

    Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has been found to have therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those with deficiencies in the homologous recombination repair (HRR) pathway. Histone deacetylases (HDACs) are important for enabling functional HRR of DNA by regulating the expression of HRR-related genes and promoting the accurate assembly of HRR-directed sub-nuclear foci. Thus, HDAC inhibitors have recently emerged as a therapeutic agent for treating cancer by inhibiting DNA repair. Based on this, HDAC inhibition could be predicted to enhance the anti-tumor effect of PARP inhibitors in cancer cells by blocking the HRR pathway. We determined whether suberoylanilide hydroxamic acid (SAHA), a HDAC inhibitor, could enhance the anti-tumor effects of olaparib on breast cancer cell lines using a cytotoxic assay, cell cycle analysis, and Western blotting. We evaluated how exposure to SAHA affects the expression of HRR-associated genes. The accumulation of DNA double strand breaks (DSBs) induced by combination treatment was assessed. Induction of autophagy was monitored by imaging green fluorescent protein-tagged microtubule-associated protein 1A/1B-light chain 3 (LC3) expression following co-treatment with olaparib and SAHA. These in vitro data were validated in vivo using a human breast cancer xenograft model. Triple-negative breast cancer cell (TNBC) lines showed heterogeneous responses to the PARP and HDAC inhibitors. Co-administration of olaparib and SAHA synergistically inhibited the growth of TNBC cells that expressed functional Phosphatase and tensin homolog (PTEN). This effect was associated with down-regulation of the proliferative signaling pathway, increased apoptotic and autophagic cell death, and accumulation of DNA damage. The combined anti-tumor effect of olaparib and SAHA was also observed in a xenograft model. These data suggest that PTEN expression in TNBC cells can

  15. Never Die Alone: Death and Birth in Pure Land Buddhism : Jonathan Watts and Yoshiharu Tomatsu, editors, 2008, Jodo Shu Press (Tokyo, 978-4-883-63041-7, 175 pp.).

    PubMed

    Maymind, Ilana

    2017-05-29

    This is a review of a collection of six essays. These essays, with the exception of one, are written by the followers of Shin Buddhism (Pure Land Buddhism). The last essay in this collection is written from the perspective of Theravada Buddhism rather than Mahayana Buddhism. This collection is a result of the initiative by Rev. Yoshiharu Tomatsu who, as a Buddhist priest, has acquired hands-on experience in dealing with grieving Temple members and became acutely aware of the discrepancy between a medical system and a ritualistic Buddhist system. While a medical system overlooks the spiritual needs of the dying, a Buddhist temple system neglects the spiritual needs of the living. This book ensued from a project that was initiated in 2006 and focused on the above-mentioned missing links, aiming to bring into conversation medical and religious practitioners.

  16. HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes

    PubMed Central

    Singh, Jaspreet; Khan, Mushfiquddin; Singh, Inderjit

    2011-01-01

    X-adrenoleukodystrophy (X-ALD) is a peroxisomal metabolic disorder caused by mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). The consistent metabolic abnormality in all forms of X-ALD is an inherited defect in the peroxisomal β-oxidation of very long chain FAs (VLCFAs >C22:0) and the resultant pathognomic accumulation of VLCFA. The accumulation of VLCFA leads to a neuroinflammatory disease process associated with demyelination of the cerebral white matter. The present study underlines the importance of a potent histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA) in inducing the expression of ABCD2 [adrenoleukodystrophy-related protein (ALDRP)], and normalizing the peroxisomal β-oxidation, as well as the saturated and monounsaturated VLCFAs in cultured human skin fibroblasts of X-ALD patients. The expression of ELOVL1, the single elongase catalyzing the synthesis of both saturated VLCFA (C26:0) and monounsaturated VLCFA (C26:1), was also reduced by SAHA treatment. In addition, using Abcd1/Abcd2-silenced mouse primary astrocytes, we also examined the effects of SAHA in VLCFA-induced inflammatory response. SAHA treatment decreased the inflammatory response as expression of inducible nitric oxide synthase, inflammatory cytokine, and activation of NF-κB in Abcd1/Abcd2-silenced mouse primary astrocytes was reduced. These observations indicate that SAHA corrects both the metabolic disease of VLCFA as well as secondary inflammatory disease; therefore, it may be an ideal drug candidate to be tested for X-ALD therapy in humans PMID:21891797

  17. HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.

    PubMed

    Singh, Jaspreet; Khan, Mushfiquddin; Singh, Inderjit

    2011-11-01

    X-adrenoleukodystrophy (X-ALD) is a peroxisomal metabolic disorder caused by mutations in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy protein (ALDP). The consistent metabolic abnormality in all forms of X-ALD is an inherited defect in the peroxisomal β-oxidation of very long chain FAs (VLCFAs >C22:0) and the resultant pathognomic accumulation of VLCFA. The accumulation of VLCFA leads to a neuroinflammatory disease process associated with demyelination of the cerebral white matter. The present study underlines the importance of a potent histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA) in inducing the expression of ABCD2 [adrenoleukodystrophy-related protein (ALDRP)], and normalizing the peroxisomal β-oxidation, as well as the saturated and monounsaturated VLCFAs in cultured human skin fibroblasts of X-ALD patients. The expression of ELOVL1, the single elongase catalyzing the synthesis of both saturated VLCFA (C26:0) and monounsaturated VLCFA (C26:1), was also reduced by SAHA treatment. In addition, using Abcd1/Abcd2-silenced mouse primary astrocytes, we also examined the effects of SAHA in VLCFA-induced inflammatory response. SAHA treatment decreased the inflammatory response as expression of inducible nitric oxide synthase, inflammatory cytokine, and activation of NF-κB in Abcd1/Abcd2-silenced mouse primary astrocytes was reduced. These observations indicate that SAHA corrects both the metabolic disease of VLCFA as well as secondary inflammatory disease; therefore, it may be an ideal drug candidate to be tested for X-ALD therapy in humans.

  18. EDITORIAL: Incoming Editor-in-Chief Incoming Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Birch, David

    2012-01-01

    It is a pleasure and an honour for me to be taking over as Editor-in-Chief of Measurement Science and Technology. MST is well known across research communities worldwide as a leading journal in which to publish new techniques and instrumentation. It has gained this enviable position largely because of the excellent guidance of its Editorial Board and dedicated staff at Institute of Physics Publishing over many years. I want to highlight in particular the contribution of the outgoing Editor Peter Hauptmann, and other Editors before him, in making the journal truly international. We thank Peter immensely for all his hard work in leading the journal, having exceptionally served two terms, each of five years. I come into the post of Editor at a very interesting and challenging time for research. The global recession is leading to cuts in research funding in many countries, researchers and their outputs are coming under closer scrutiny than ever before, and more is being expected of them. Journals play a critical role in monitoring and maintaining research standards, but we should be careful not to assume that journal Impact Factor is the sole measure of research quality. Although expediency may sometimes demand it, Impact Factor, as practitioners know, is subject dependent. One of the great things about science and technology for me is its level playing field. The key point is still innovation no matter where the work is done or where it is published. MST has a long pedigree of being the natural home of the highest quality papers from leading researchers wishing to report novel instrumentation and techniques. 2013 will mark the 90th anniversary of MST and we look forward to celebrating in style its sustained success. I recall with pride the first paper I published in Journal of Physics E: Scientific Instruments (as MST was previously titled) back in 1977. The paper reported the design and application of an early fluorescence lifetime spectrometer that I had constructed

  19. An Update: 1976 and 1987 Editors' Predictions of Audience Reactions to Videotex and A Comparison: 1987 Audience Reactions and 1976 and 1987 Editors' Predictions.

    ERIC Educational Resources Information Center

    Davenport, Lucinda D.

    To discover if editors' perceptions of audience opinions had changed and to determine the accuracy of editors' predictions regarding readers' reactions to using videotex, a 1987 study repeated a 1976 survey of Associated Press managing editors, and compared the responses with the original survey results. Surveys were sent to 302 Associated Press…

  20. Writing filter processes for the SAGA editor, appendix G

    NASA Technical Reports Server (NTRS)

    Kirslis, Peter A.

    1985-01-01

    The SAGA editor provides a mechanism by which separate processes can be invoked during an editing session to traverse portions of the parse tree being edited. These processes, termed filter processes, read, analyze, and possibly transform the parse tree, returning the result to the editor. By defining new commands with the editor's user defined command facility, which invoke filter processes, authors of filter can provide complex operations as simple commands. A tree plotter, pretty printer, and Pascal tree transformation program were already written using this facility. The filter processes are introduced, parse tree structure is described and the library interface made available to the programmer. Also discussed is how to compile and run filter processes. Examples are presented to illustrate aspect of each of these areas.

  1. SIRE: A Simple Interactive Rule Editor for NICBES

    NASA Technical Reports Server (NTRS)

    Bykat, Alex

    1988-01-01

    To support evolution of domain expertise, and its representation in an expert system knowledge base, a user-friendly rule base editor is mandatory. The Nickel Cadmium Battery Expert System (NICBES), a prototype of an expert system for the Hubble Space Telescope power storage management system, does not provide such an editor. In the following, a description of a Simple Interactive Rule Base Editor (SIRE) for NICBES is described. The SIRE provides a consistent internal representation of the NICBES knowledge base. It supports knowledge presentation and provides a user-friendly and code language independent medium for rule addition and modification. The SIRE is integrated with NICBES via an interface module. This module provides translation of the internal representation to Prolog-type rules (Horn clauses), latter rule assertion, and a simple mechanism for rule selection for its Prolog inference engine.

  2. JGR-Solid Earth and Planets editor Seth A. Stein

    NASA Astrophysics Data System (ADS)

    Katzoff, Judith A.

    Seth A. Stein, one of the editors of the Journal of Geophysical Research—Solid Earth and Planets, says that his approach to editing the journal is based on the premise that authors, reviewers, and editors are all drawn from the same community: the journal's readers. “We all want JGR to publish interesting papers of the highest possible quality. Each of us believes that the papers we review are improved by our comments. It follows, although it is a little harder for most of us to accept, that our own papers generally contain better science and are more useful to readers as a result of reviews,” Stein told Eos.Stein, an associate professor of geological sciences at Northwestern University (Evanston, Ill.), is one of the seven editors of JGR—Solid Earth and Planets for 1987 and 1988 (see box). His specialties are tectonophysics and seismology.

  3. Core competencies for scientific editors of biomedical journals: consensus statement.

    PubMed

    Moher, David; Galipeau, James; Alam, Sabina; Barbour, Virginia; Bartolomeos, Kidist; Baskin, Patricia; Bell-Syer, Sally; Cobey, Kelly D; Chan, Leighton; Clark, Jocalyn; Deeks, Jonathan; Flanagin, Annette; Garner, Paul; Glenny, Anne-Marie; Groves, Trish; Gurusamy, Kurinchi; Habibzadeh, Farrokh; Jewell-Thomas, Stefanie; Kelsall, Diane; Lapeña, José Florencio; MacLehose, Harriet; Marusic, Ana; McKenzie, Joanne E; Shah, Jay; Shamseer, Larissa; Straus, Sharon; Tugwell, Peter; Wager, Elizabeth; Winker, Margaret; Zhaori, Getu

    2017-09-11

    Scientific editors are responsible for deciding which articles to publish in their journals. However, we have not found documentation of their required knowledge, skills, and characteristics, or the existence of any formal core competencies for this role. We describe the development of a minimum set of core competencies for scientific editors of biomedical journals. The 14 key core competencies are divided into three major areas, and each competency has a list of associated elements or descriptions of more specific knowledge, skills, and characteristics that contribute to its fulfillment. We believe that these core competencies are a baseline of the knowledge, skills, and characteristics needed to perform competently the duties of a scientific editor at a biomedical journal.

  4. Implementing a computerized text-management system: an editor's view

    SciTech Connect

    Mason, J.D.

    1980-01-01

    The advent of sophisticated function-key-driven programs for handling text on a video-display terminal enables the editorial staff of a publications department to take an active role on a computerized text-management team, along with compositors and other keyboard operators. Although there are still many things that editors cannot do on a computer terminal, the bulk of manipulating straight text can be speeded, and the problems of rekeyboarding and interpretation of editorial markings can be largely bypassed. The computer also gives editors new tools that open the way for greater control over both the editorial process and the quality of technical publishing. 5 figures.

  5. Featuring the special issue editor: associate professor Alexandros G. Georgakilas.

    PubMed

    Georgakilas, Alexandros G

    2012-12-31

    In this 'Featuring the editor' article, we introduce Assoc. Professor Alexandros G. Georgakilas as the guest editor for this Special Issue of Cancer Letters. His main research, educational and editorial achievements in his academic career are presented with emphasis on the various milestones of his involvement in science for more than twenty years. His primary interests in research focus on various radiation and cancer biology aspects especially the involvement of clustered DNA lesions in carcinogenesis. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  6. EDITORIAL: New Editor-in-Chief for Nanotechnology New Editor-in-Chief for Nanotechnology

    NASA Astrophysics Data System (ADS)

    Couzin, Nina

    2009-01-01

    Nanotechnology is proud to announce the appointment of Professor Mark Reed, Yale University, as the new Editor-in-Chief from January 2009. Mark Reed holds the Harold Hodgkinson Chair of Engineering and Applied Science at Yale University. He has made significant contributions in the areas of quantum dots, electronic transport in nanoscale and mesoscopic systems, artificially structured materials and devices, and molecular electronics. Professor Reed has been associated with the journal as an Editorial Board member for a number of years and we are delighted that he has agreed to take on the scientific leadership of the journal in its 20th year. We also take the opportunity to thank Professor Mark Welland, Cambridge University, for his work as Editor-in-Chief since 2001, and for presiding over the re-launch and remarkable growth of the journal since then. Nanotechnology is unique in that it was the first peer-reviewed journal in the area of nanoscience, the first issue appearing in 1990. Since then it has established a distinguished publication record and has become a leading journal covering all aspects of nanoscale science and technology, as well as specializing in in-depth, comprehensive articles not seen in letter format journals. Published weekly and featuring subject sections, the journal is truly multidisciplinary in nature and is an excellent medium to quickly deliver your research results to readers worldwide. Nanotechnology is proud to be offering some of the fastest publication times around (less than three months on average from receipt to online publication). We offer free online access to all published papers for 30 days, ensuring that anyone with access to the internet will be able to read your paper. We were also the first journal to give our authors the opportunity to communicate their research to a wider audience through nanotechweb.org and other IOP websites. See the journal's homepage at www.iop.org/Journals/nano for more details. We are looking

  7. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network.

    PubMed

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability -, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology. Copyright © 2017. Publicado por Masson Doyma México S.A.

  8. Announcement: New Editor-In-Chief, Robert C. Kennicutt, Jr.

    NASA Astrophysics Data System (ADS)

    Abt, Helmut A.

    1999-06-01

    Effective 1999 July 1, all new manuscripts for Part 1 of The Astrophysical Journal and The Astrophysical Journal Supplement Series should be sent to Dr. Robert C. Kennicutt, Jr., Editor-in-Chief The Astrophysical Journal Steward Observatory University of Arizona Tucson, AZ 85721-0065 The other means of contact are telephone, (520) 621-5145 FAX, (520) 621-5153 and e-mail, apj@as.arizona.edu. For express packages please use the street address of 933 North Cherry Avenue. Dr. Kennicutt will be assisted by several of my loyal coworkers, who will move across the street. Manuscripts received before July 1 will be handled by the current editor until most of their problems have been resolved, at which point the remainder will be sent to Dr. Kennicutt's office. Manuscripts for the Letters should, as before, be sent directly to Dr. Alex Dalgarno at the Center for Astrophysics in Cambridge, MA. We are fortunate that a person with as much experience in research and proven good judgment as Dr. Kennicutt is willing to accept this difficult and time-consuming responsibility. He will be only the seventh Managing Editor or Editor-in-Chief that this Journal has had in its 104 years. Please give him the cooperation and help that you have given the current editor. It has been my privilege to work for 28 years with many of the best astrophysicists in the world and to publish their papers. This was done with the help of the AAS Publications Board and AAS officers, the efforts of Peter Boyce and Evan Owens who made the on-line edition of the Journal possible, three Associate Editors, a score of Scientific Editors, a hardworking staff of six in Tucson, up to 25 production controllers and manuscript editors at the University of Chicago Press, and the thousands of astronomers throughout the world who served as referees. The original masthead called this journal ``An International Review of Spectroscopy and Astronomical Physics.'' That subtitle is no longer appropriate because we do not

  9. Announcement: New Editor-In Robert C. Kennicutt

    NASA Astrophysics Data System (ADS)

    Abt, Helmut A.

    1999-06-01

    Effective 1999 July 1, all new manuscripts for Part 1 of The Astrophysical Journal and The Astrophysical Journal Supplement Series should be sent to Dr. Robert C. Kennicutt, Editor-in-Chief The Astrophysical Journal Steward Observatory University of Arizona Tucson, AZ 85721-0065 The other means of contact are telephone, (520) 621-5145 FAX, (520) 621-5153 and e-mail, apj@as.arizona.edu. For express packages please use the street address of 933 North Cherry Avenue. Dr. Kennicutt will be assisted by several of my loyal coworkers, who will move across the street. Manuscripts received before July 1 will be handled by the current editor until most of their problems have been resolved, at which point the remainder will be sent to Dr. Kennicutt's office. Manuscripts for the Letters should, as before, be sent directly to Dr. Alex Dalgarno at the Center for Astrophysics in Cambridge, MA. We are fortunate that a person with as much experience in research and proven good judgment as Dr. Kennicutt is willing to accept this difficult and time-consuming responsibility. He will be only the seventh Managing Editor or Editor-in-Chief that this Journal has had in its 104 years. Please give him the cooperation and help that you have given the current editor. It has been my privilege to work for 28 years with many of the best astrophysicists in the world and to publish their papers. This was done with the help of the AAS Publications Board and AAS officers, the efforts of Peter Boyce and Evan Owens who made the on-line edition of the Journal possible, three Associate Editors, a score of Scientific Editors, a hardworking staff of six in Tucson, up to 25 production controllers and manuscript editors at the University of Chicago Press, and the thousands of astronomers throughout the world who served as referees. The original masthead called this journal ``An International Review of Spectroscopy and Astronomical Physics.'' That subtitle is no longer appropriate because we do not publish

  10. Announcement: New Editor-in-Chief Robert C. Kennicutt

    NASA Astrophysics Data System (ADS)

    Abt, Helmut A.

    1999-05-01

    Effective 1999 July 1, all new manuscripts for Part 1 of The Astrophysical Journal and The Astrophysical Journal Supplement Series should be sent to Dr. Robert C. Kennicutt, Editor-in-Chief The Astrophysical Journal Steward Observatory University of Arizona Tucson, AZ 85721-0065 The other means of contact are telephone, (520) 621-5145 FAX, (520) 621-5153 and e-mail, apj@as.arizona.edu. For express packages please use the street address of 933 North Cherry Avenue. Dr. Kennicutt will be assisted by several of my loyal coworkers, who will move across the street. Manuscripts received before July 1 will be handled by the current editor until most of their problems have been resolved, at which point the remainder will be sent to Dr. Kennicutt's office. Manuscripts for the Letters should, as before, be sent directly to Dr. Alex Dalgarno at the Center for Astrophysics in Cambridge, MA. We are fortunate that a person with as much experience in research and proven good judgment as Dr. Kennicutt is willing to accept this difficult and time-consuming responsibility. He will be only the seventh Managing Editor or Editor-in-Chief that this Journal has had in its 104 years. Please give him the cooperation and help that you have given the current editor. It has been my privilege to work for 28 years with many of the best astrophysicists in the world and to publish their papers. This was done with the help of the AAS Publications Board and AAS officers, the efforts of Peter Boyce and Evan Owens who made the on-line edition of the Journal possible, three Associate Editors, a score of Scientific Editors, a hardworking staff of six in Tucson, up to 25 production controllers and manuscript editors at the University of Chicago Press, and the thousands of astronomers throughout the world who served as referees. The original masthead called this journal ``An International Review of Spectroscopy and Astronomical Physics.'' That subtitle is no longer appropriate because we do not publish

  11. Developing and Presenting Auditory Demonstrations: Two Sound Editor Programs

    ERIC Educational Resources Information Center

    Firment, Michael J.

    2006-01-01

    Experiencing examples of auditory phenomena can clarify textbook and lecture explanations. The addition of visual displays to auditory demonstrations can make them more understandable. Two sound editor programs, Audacity[R] and Adobe Audition Pro 2.0[R], provide excellent capabilities for the display and authoring of auditory demonstrations.…

  12. IN DEFENSE OF ECORISK ASSESSMENT (LETTER TO EDITOR)

    EPA Science Inventory

    Dear Editor: We are writing to convey a more accurate portrayal of the status of ecological ("environmental" in Europe) risk assessment that was presented in the recent article by M. Power and L.S. McCarty (Fallacies in Ecological Risk Assessment Practices," August 1997, pp 370A-...

  13. Most Business Editors Find Journalism Graduates Still Unprepared

    ERIC Educational Resources Information Center

    Pardue, Mary Jane

    2014-01-01

    In 2002, a study was published in "Newspaper Research Journal" that explored the preparedness of graduating journalism students to cover business news. In 2012, a follow-up survey of business editors at the nation's daily newspapers was done to see whether progress had been made in the training of journalism students for the…

  14. Ethical dilemmas in scientific publication: pitfalls and solutions for editors.

    PubMed

    Gollogly, Laragh; Momen, Hooman

    2006-08-01

    Editors of scientific journals need to be conversant with the mechanisms by which scientific misconduct is amplified by publication practices. This paper provides definitions, ways to document the extent of the problem, and examples of editorial attempts to counter fraud. Fabrication, falsification, duplication, ghost authorship, gift authorship, lack of ethics approval, non-disclosure, 'salami' publication, conflicts of interest, auto-citation, duplicate submission, duplicate publications, and plagiarism are common problems. Editorial misconduct includes failure to observe due process, undue delay in reaching decisions and communicating these to authors, inappropriate review procedures, and confounding a journal's content with its advertising or promotional potential. Editors also can be admonished by their peers for failure to investigate suspected misconduct, failure to retract when indicated, and failure to abide voluntarily by the six main sources of relevant international guidelines on research, its reporting and editorial practice. Editors are in a good position to promulgate reasonable standards of practice, and can start by using consensus guidelines on publication ethics to state explicitly how their journals function. Reviewers, editors, authors and readers all then have a better chance to understand, and abide by, the rules of publishing.

  15. What Authors Want From Journal Reviewers and Editors

    ERIC Educational Resources Information Center

    Nickerson, Raymond S.

    2005-01-01

    Peer review is the primary means of ensuring the maintenance of standards that are deemed appropriate for scientific publications. There are many similarities, but also some differences, in the way the review process is conducted by different editors, and there are differences among reviewers in how they deal with the same manuscript--the…

  16. Females' participation in psychopharmacology research as authors, editors, and subjects.

    PubMed

    Poling, Alan; Durgin, Amy; Bradley, Kelly P; Porter, Lindsay K; Van Wagner, Karen; Weeden, Marc; Panos, John J

    2009-04-01

    This study determined the involvement of women as first authors and other authors for every article published in Experimental and Clinical Psychopharmacology, Pharmacology Biochemistry and Behavior, and Psychopharmacology in 1991, 1996, 2001, and 2006. Their involvement as editors also was determined. Women's participation as authors, but not as editors, slightly increased over time. In 2006, 43% of first authors, 38% of other authors, and 24% of editors were women. The gender of subjects was examined for the same years and journals, but could not be determined for 6% and 9% of articles employing nonhuman and human subjects, respectively. In 2006, when subjects' gender could be determined, 77% of articles involving nonhuman subjects used only males, 9% only females, and 14% both males and females. In articles using human subjects in that same year, 17% involved only males, 6% only females, and 77% both males and females. Women researchers clearly make substantial contributions to the psychopharmacology literature, but are nonetheless underrepresented as editors. Findings regarding subjects indicate that there is growing recognition of the importance of gender as a determinant of drug effects, although the vast majority of nonhuman studies continue to involve only male subjects.

  17. Particle size fraction -Response: Letter to the Editors

    EPA Science Inventory

    To the Editors: We, the undersigned, would like to comment on the article by Cho et al. (Cho et al. 2009), which was published in the November 2009 issue (volume 11, number 11, page 1682-1689) of Environmental Health Perspectives. We read the paper with great interest as the dis...

  18. August 2017 Letters to the Editor-in-Chief.

    PubMed

    2017-08-01

    Letter to the Editor-in-Chief of JOSPT as follows: "Manual Therapy: More Than Elaborate Swordplay" with Authors' Response "Comparing Dry Needling to Corticosteroid Injection for Greater Trochanteric Pain Syndrome" with Authors' Response J Orthop Sports Phys Ther 2017;47(8):580-585. doi:10.2519/jospt.2017.0204.

  19. September 2017 Letter to the Editor-in-Chief.

    PubMed

    2017-09-01

    Letter to the Editor-in-Chief of JOSPT as follows: "Clinically Meaningful Outcome Measures in Patients With Shoulder Problems" with Authors' Response J Orthop Sports Phys Ther 2017;47(9):693-695. doi:10.2519/jospt.2017.0205.

  20. LACE: A Web-Based, Structured Editor for PDS Metadata

    NASA Astrophysics Data System (ADS)

    Rose, M.; Keller, R.; Sarram, P.

    2015-06-01

    PDS has moved to XML-based metadata, but many scientists are not familiar with XML and find its structure complicated. For these reasons, we have created LACE, an editor for PDS metadata that hides the complexity of XML from the user.

  1. Particle size fraction -Response: Letter to the Editors

    EPA Science Inventory

    To the Editors: We, the undersigned, would like to comment on the article by Cho et al. (Cho et al. 2009), which was published in the November 2009 issue (volume 11, number 11, page 1682-1689) of Environmental Health Perspectives. We read the paper with great interest as the dis...

  2. Most Business Editors Find Journalism Graduates Still Unprepared

    ERIC Educational Resources Information Center

    Pardue, Mary Jane

    2014-01-01

    In 2002, a study was published in "Newspaper Research Journal" that explored the preparedness of graduating journalism students to cover business news. In 2012, a follow-up survey of business editors at the nation's daily newspapers was done to see whether progress had been made in the training of journalism students for the…

  3. IN DEFENSE OF ECORISK ASSESSMENT (LETTER TO EDITOR)

    EPA Science Inventory

    Dear Editor: We are writing to convey a more accurate portrayal of the status of ecological ("environmental" in Europe) risk assessment that was presented in the recent article by M. Power and L.S. McCarty (Fallacies in Ecological Risk Assessment Practices," August 1997, pp 370A-...

  4. Righting the Wrongs of Writing: Copy Editors Speak Out

    ERIC Educational Resources Information Center

    Alexander, Jaclyn J.; Wall, Judy

    1975-01-01

    The major part of APGA Press production editors' jobs is copy editing manuscripts before they are set in type. Two APGA Press Staff members use specific examples to illustrate the grammatical and stylistic errors that cause problems for them and, if not corrected, for readers. (Author)

  5. Manuals for Editors and Authors: A Decision Model.

    ERIC Educational Resources Information Center

    Kirschner, Paul A.

    A series of eight manuals dealing with the triad text characteristics--learning processes--learning outcomes are being prepared for use by authors and editors as an aid in the design and writing of educational texts. These manuals are based upon a model for the functioning of text characteristics which in turn is part of a decision model for the…

  6. Publishing in Educational Psychology Journals: Comments from Editors

    ERIC Educational Resources Information Center

    Nihalani, Priya K.; Mayrath, Michael C.

    2008-01-01

    The following paper emphasizes the importance of publishing and learning how to publish in educational psychology journals. We have compiled a set of recommendations based on advice from editors in the field and several other sources on how to publish. Additionally, this paper provides a step-by-step guide that graduate students and junior faculty…

  7. An Editor's View of the State of Applied Developmental Psychology.

    ERIC Educational Resources Information Center

    Cocking, Rodney R.

    Addressed are issues and problems of definition that arose in establishing a new scientific journal. Specifically, the problems considered are those confronting the "Journal of Applied Developmental Psychology" (JADP) in its first 5 years of existence. The first matter of definition discussed is the editor's role. Ways in which editorial…

  8. Publishing in Educational Psychology Journals: Comments from Editors

    ERIC Educational Resources Information Center

    Nihalani, Priya K.; Mayrath, Michael C.

    2008-01-01

    The following paper emphasizes the importance of publishing and learning how to publish in educational psychology journals. We have compiled a set of recommendations based on advice from editors in the field and several other sources on how to publish. Additionally, this paper provides a step-by-step guide that graduate students and junior faculty…

  9. How about the Real World? Students Learn from Experienced Editors.

    ERIC Educational Resources Information Center

    Black, Sharon; Wilcox, Brad

    1998-01-01

    Surveys professional editors (who work with publishing companies and magazines with national and international circulations) concerning advice to students on how writers write. Finds four main themes: (1) plan and organize carefully; (2) revise your work thoughtfully; (3) use words purposefully; and (4) correct errors thoroughly. (RS)

  10. The Editor and the Fund Raiser: Partners or Adversaries?

    ERIC Educational Resources Information Center

    Collins, Walt; Hincker, Lawrence; Yoe, Mary Ruth; Loyless, Darrell

    1999-01-01

    In a panel format, experienced college publications editors and development professionals discussed their responses to three scenarios describing clashes between alumni magazine staff and development officers: writing donor profiles; reporting negative campus news; and publishing campaign materials in the alumni magazine. Excerpts of the…

  11. Proteasome inhibitor MG-132 enhances histone deacetylase inhibitor SAHA-induced cell death of chronic myeloid leukemia cells by an ROS-mediated mechanism and downregulation of the Bcr-Abl fusion protein

    PubMed Central

    ZHOU, WENJING; ZHU, WEIWEI; MA, LIYA; XIAO, FENG; QIAN, WENBIN

    2015-01-01

    Recently, there has been progress in the treatment of chronic myeloid leukemia (CML). However, novel therapeutic strategies are required in order to address the emerging problem of imatinib resistance. Histone deacetylase inhibitors (HDACi) and proteasome inhibitors are promising alternatives, and may be amenable to integration with current therapeutic approaches. However, the mechanisms underlying the interaction between these two agents remain unclear. The present study assessed the cytotoxic effect of the HDACi, suberoylanilide hydroxamic acid (SAHA), in combination with the proteasome inhibitor, MG-132, in imatinib-sensitive K562 and imatinib-resistant K562G cells, and investigated the mechanism underlying this effect. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method and protein expression levels were determined by western blotting. Reactive oxygen species (ROS) generation levels were observed under a fluorescence microscope The results indicated that SAHA and MG-132 act in a synergistic manner to induce cell death in K562 and K562G cells. This effect was associated with Bcr-Abl downregulation and the production of ROS. Notably, the ROS scavenger, N-acetyl-L-cysteine, almost fully reversed the cell death and Bcr-Abl downregulation that was induced by the combination of SAHA and MG-132. By contrast, the pan-caspase inhibitor, z-VAD-fmk, only partially reversed the cell death induced by these two drugs in CML cells. These results indicated that increased intracellular ROS levels are important in the induction of cell death and the downregulation of Bcr-Abl. In conclusion, the present results suggested that combined SAHA and MG-132 may be a promising treatment for CML. PMID:26722260

  12. Editors-in-Chief of Medical Journals: Are They Experts, Authorities, Both, or Neither?

    ERIC Educational Resources Information Center

    Zsindely, Sandor; Schubert, Andras

    1989-01-01

    Uses citation analysis to study the professional status and influence of the editors-in-chief of 769 medical journals. Finds that these editors-in-chief are, at least in their own specialties, not necessarily experts but authorities. (SR)

  13. EDITORIAL: Outgoing Editor-in-Chief Outgoing Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Hauptmann, Peter

    2012-01-01

    I started in 2002 as Editor-in-Chief of a well established journal—MST (Measurement Science and Technology). It was a time when modern means of communication offered new opportunities for the scientific community—for all scientists and engineers whether at universities, in industry or at other institutions—to access better quality information in a shorter time. This development helped us to be more efficient in our daily scientific work and to anticipate new trends faster than before. A flood of information was created by different search engines. A few online journals or journals published in emerging countries with a similar profile to MST appeared on the market. MST had to provide new answers in response to these developments. In 2002 I postulated two requirements to the journal. Firstly, the publisher has to be up to date. My impression over the years has been that IOPP is excellently organized. That has made it easier for the board members and all our reviewers to concentrate on the scientific aspects of our input to the journal. During all my visits to Bristol or my contacts with the IOPP staff I always met very professional and enthusiastic staff members. They have not only supported and encouraged the ideas and initiatives of the Editorial Board members, but they have also worked hard on establishing one of the most effective journal operations in the field of measurement science and technology. Many authors are well aware of this. Thus I am able to declare that the first requirement for a successful journal has been met. Secondly, the scientific level has to be high and the journal should attract readers from all over the world. This task was the responsibility of the Editorial Board members and of myself. Our strategy was on the one hand to ensure continuity in MST but on the other hand to be open to new trends and developments. Examples of these new aspects of the journal are fields like micro- and nanometrology, measurement techniques for

  14. EDITORIAL: Farewell from the outgoing Editor-in-Chief Farewell from the outgoing Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Rost, Jan Michael

    2011-01-01

    I am very pleased to announce that Professor Paul Corkum will be taking on the position of Editor-in-Chief at Journal of Physics B: Atomic, Molecular and Optical Physics (J. Phys. B) from the beginning of January 2011. During my term as Editor-in-Chief atomic, molecular and optical science has continued to change rapidly: we have seen ultracold physics widening its original emphasis on Bose-Einstein condensates to the entanglement of light and matter in the most general sense towards a science of information. At the same time attosecond science and interaction of matter with short x-ray pulses develops rapidly. I am very happy that J. Phys. B with Paul Corkum as Editor-in-Chief will play a central role in publishing exciting results from this field. I would like to thank the publishing team at J. Phys. B for their fantastic job, in particular for the quality of the refereeing system the team has been able to maintain while at the same time bringing down the publication times considerably. I thank them all for the help and support they have given me in the role of Editor-in-Chief and wish them the very best for the future. Last and certainly not least I would like to thank you, the authors, referees and readers, for the support of J. Phys. B.

  15. Sensitization of RPE cells by alphaB-crystallin siRNA to SAHA-induced stage 1 apoptosis through abolishing the association of alphaB-crystallin with HDAC1 in SC35 speckles.

    PubMed

    Noh, Seung Jin; Jeong, Woo Jin; Rho, Jee Hyun; Shin, Dong Min; Ahn, Hee Bae; Park, Woo Chan; Rho, Sae Heun; Soung, Young Hwa; Kim, Tae Hyun; Park, Bong Soo; Yoo, Young Hyun

    2008-11-01

    To better understand the mechanism underlying the anti-apoptotic activity of alphaB-crystallin in RPE cells. Cells of the human retinal pigment epithelial line ARPE-19 were treated with a histone deacetylase inhibitor (HDACI), suberoylanilide hydroxamic acid (SAHA), with or without alphaB-crystallin siRNA. To examine the mechanism underlying the cell death induced in ARPE-19 cells, nuclear staining, flow cytometry, DNA electrophoresis, pulse field gel electrophoresis, Western blot analysis, confocal microscopy, and coimmunoprecipitation assay were undertaken. The present study demonstrated that an HDACI, SAHA, at the usual doses or the silencing of alphaB-crystallin by siRNA alone did not effectively induce apoptosis in ARPE-19 cells. Silencing of alphaB-crystallin likely abolishes the anti-apoptotic activity of alphaB-crystallin. The data indicated that silencing of alphaB-crystallin sensitizes ARPE19 cells to SAHA-induced apoptosis and leads them to stage 1 apoptosis. alphaB-Crystallin associates with HDAC1 on SC35 speckles, and silencing of alphaB-crystallin abolishes this association, resulting in the induction of apoptosis. The data indicated that the association between alphaB-crystallin and HDAC1 on SC35 speckles plays a pivotal role in anti-apoptotic activity. Knockout of alphaB-crystallin may be a promising new approach to enhance therapeutic potency for proliferative vitreoretinopathy without compromising efficacy.

  16. Preparing Students To Work on Newspaper Copy Desks: Are Educators Meeting Editors' Expectations?

    ERIC Educational Resources Information Center

    Auman, Ann E.; Cook, Betsy B.

    A study surveyed two groups in the fall of 1994, journalism educators and newspaper editors. Educators completed a survey regarding the course content and skill areas emphasized in beginning level copy editing courses, while editors were asked to respond to questions regarding the skills they expect entry-level copy editors to have. Respondents…

  17. FLAn: A Free Hypermedia Editor to Create Foreign Language Learning Units

    ERIC Educational Resources Information Center

    Kilickaya, Ferit, Ed.

    2011-01-01

    Glossing words is done via special software called multimedia editors. Foreign Language Annotator (FLAn), created by Thibeault (2011), is one of these multimedia editors. FLAn (Foreign Language Annotator), a free hypermedia editor that works on both Macs and PCs, allows instructors to turn static texts into dynamic learning units by attaching…

  18. PREFACE: Introductory remarks from the Editors Introductory remarks from the Editors

    NASA Astrophysics Data System (ADS)

    Knobloch, E.; Meseguer, A.; Marques, F.

    2012-06-01

    The local organizers of the 4th BIFD (Bifurcations and Instabilities in Fluid Dynamics) Symposium held in Barcelona on 18-21 July 2011 would like to thank the editors of Fluid Dynamics Research for offering us the opportunity of publishing a peer-reviewed special issue of the journal with a selection of the contributions presented at this conference. We thank both the authors and the referees for working with us on the rather tight schedule necessary to release the issue within one year of the date of the conference. We also thank the invited speakers, B Eckhardt, L Tuckerman, and J M Vega, for contributing keynote papers to this special issue. The series of BIFD symposia started as a small workshop in Madeira, Portugal, in 2004 with no more than 20 participants. This number increased rapidly during the second and third symposia held in 2006 (Denmark) and 2009 (United Kingdom), with 40 and 110 participants, respectively. The 4th BIFD symposium has consolidated this event as one of the leading conferences in hydrodynamic stability, with nearly 200 participants from around the world. The main goal of this conference is to bring together scientists and engineers from different disciplines directly or indirectly related to fluid dynamics, bifurcation theory and hydrodynamic stability theory. The conference covered many research areas within the aforementioned fields, ranging from thermal, shear and centrifugal flows to biofluids, films, drops, viscoelastic flows and magnetohydrodynamics. The structure of the conference, with invited plenary talks and focused sessions, helped the participants find their home in the conference and share state-of-the-art knowledge within the field of hydrodynamic instabilities. The financial support from MICINN (Spanish Ministry of Science and Innovation, Grant no FIS2009-08065-E) and UPC (Universitat Politècnica de Catalunya) is greatly appreciated. The local organizers would also like to thank ETSAB (Barcelona School of Architecture

  19. Wysession begins term as Eos Section Editor for Seismology

    NASA Astrophysics Data System (ADS)

    Wysession, Michael

    In mid-April, Michael Wysession, an associate professor in the Department of Earth and Planetary Sciences at Washington University, embarked on a 3-year term as section editor of Eos for seismology. Wysession brings to the position a strong background in research and teaching. Below are a few remarks from Wysession.“I recently became the new seismology editor for Eos. I look forward to presenting the many exciting areas of seismological research to the entire geophysical community. I have taught at Washington University since obtaining my Ph.D. at Northwestern University in 1991. My interest in seismology began during my undergraduate years at Brown University (Sc.B., 1984), but my experience as an educator began after I graduated and taught high school math and physics in Staten Island, N.Y.

  20. William E. Edmonston, Jr.: Editor, 1968-1976.

    PubMed

    Kihlstrom, John F; Frischholz, Edward J

    2010-10-01

    This article is part of an occasional series profiling editors of the American Journal of Clinical Hypnosis (AJCH). William E. Edmonston was the second editor, succeeding Milton H. Erickson. His research focused on the use of conditioning paradigms and psychophysiological measures to explore a wide variety of hypnotic phenomena, leading to a "neo-Pavlovian" theory of neutral hypnosis as physiological relaxation (anesis). A longtime professor of psychology at Colgate University, he created an interdisciplinary undergraduate major in neuroscience, and was named New York State College Professor of the Year in 1988. He gave the Journal a new look, and a greater balance of clinical and experimental papers. The article also provides background on George Barton Cutten, George H. Estabrooks, and Frank A. Pattie, pioneers of hypnosis who were linked to Edmonston.

  1. From the desk of the Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Hei, Tom K.

    2015-07-01

    Life Sciences in Space Research had a prominent presence at the International Congress of Radiation Research (ICRR) meeting held in Kyoto, Japan from May 25th-29th, with seven of the eleven editors attending the meeting. A journal booth was also put up at the pre-ICRR satellite meeting on Space Radiation and Heavy Ions in Therapy (SRHITS) held a few days earlier in Osaka. Since the inception of LSSR last year, the editors and publisher have promoted the journal at a number of major conferences including COSPAR 2014 in Moscow, the annual meeting of the Radiation Research Society and the NASA Space Radiation Investigators Meeting. These efforts have increased awareness of the journal among investigators in space life sciences and related fields. The number of monthly downloads of articles from the journal website averages 2000, a respectable number for a brand new journal.

  2. Space Weather Editors in Transition: Hail and Farewell

    NASA Astrophysics Data System (ADS)

    Knipp, Delores J.

    2017-02-01

    I hope you will join me in welcoming Dr. Daniel Welling of University of Michigan and Dr. T. Paul O'Brien of the Aerospace Corporation to the Space Weather (SWE) editorial team. Dan and Paul have answered the call to fill the shoes of two departing editors: Dr. Howard Singer and Dr. Barbara Giles. Dan brings insight related to space weather model development, while Paul brings expertise in the geospace radiation environment.

  3. Towards a document structure editor for software requirements analysis

    NASA Technical Reports Server (NTRS)

    Kowalski, Vincent J.; Lekkos, Anthony A.

    1986-01-01

    Of the six or seven phases of the software engineering life cycle, requirements analysis tends to be the least understood and the least formalized. Correspondingly, a scarcity of useful software tools exist which aid in the development of user and system requirements. It is proposed that requirements analysis should culminate in a set of documents similar to those that usually accompany a delivered Software product. The design of a software tool, the Document Structure Editor, which facilitates the development of such documentation.

  4. JGR-Solid Earth and Planets GP editor appointed

    NASA Astrophysics Data System (ADS)

    Ken Hoffman (Physics Department, California Polytechnic State University, San Luis Obispo) has been appointed GP editor for papers submitted to the Journal of Geophysical Research—Solid Earth and Planets. His tenure will be from January 1987 to December 1988. Hoffman holds a Ph.D. in geophysics from the University of California, Berkeley, and has published extensively in the areas of rock magnetism, paleomagnetism, lunar paleointensity, and most recently, geomagnetic dipole field reversal modeling.

  5. Incremental Expression Parsing for Syntax-Directed Editors

    DTIC Science & Technology

    1982-10-27

    Cretsna*refr a+b+cde ftth I / \\ ,:I \\ I’\\ / , I \\ b- ’ I I € d Figure 4-3: Correct syntax tree for"a + (b + c" d" e) ftgth" The tokens between, the...Schwartz. The Design of a Language-Directed Editor for Block-Structured Languages. In Proceedings of the ACM SIGPLAN SIGOA Symposium on Text Manipulation

  6. The STAGING Text Editor/Data Base Loader Program Manual.

    DTIC Science & Technology

    1980-05-01

    editor and the loader require the library DATAMAN which contains the lowest level data base subroutines used by STAGING. All necessary programs and...LDSETLIB=EDITLB/ DATAMAN . LISLOADEDITLDEDIT. LIBLOADEDITLBRENARK. NOGOED. CATALOGED,1 DCAHKPUxXRXR2XR. RETURNEDITLB,EDDATAMAN. REVERT. UPDATING THE DATA...library DATAMAN to properly position COMMON areas. The libraries SUPLIB and GENERLB contain successively higher level data base manipulation subroutines

  7. Reference Accuracy: Authors', Reviewers', Editors', and Publishers' Contributions

    PubMed Central

    2014-01-01

    Scientific authors are responsible for the accuracy of their writings and references to others' works. However, relying on authors is not enough when it comes to processing their manuscripts. Joint efforts of authors, peer reviewers, editors, and publishers throughout the publishing process may prevent most reference errors. This article analyzes essential aspects of bibliographic management and focuses on the importance of validating references by all stakeholders of scholarly publishing. PMID:25469055

  8. Statement on Publication Ethics for Editors and Publishers.

    PubMed

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Voronov, Alexander A; Gorin, Sergey V; Koroleva, Anna M; Kitas, George D

    2016-09-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions.

  9. Authors, editors, and the signs, symptoms and causes of plagiarism

    PubMed Central

    Shashok, Karen

    2011-01-01

    Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or “the English” (which has become a common practice) should be distinguished from intentional deceit for the purpose of stealing other authors’ ideas (which appears to remain a very rare practice). Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism. PMID:21957412

  10. A perspective on computer documentation: System developer vs. technical editor

    SciTech Connect

    Carnes, E.T.; Truett, L.F.

    1995-12-31

    Between the computer-knowledgeable {open_quotes}techie{close_quotes} and the technical writer is a chasm created by differences in knowledge bases and skills. Although this gap is widened by misunderstandings and misconceptions of system development roles, it is bridged by mutual need and dual appreciation. Often the editor/writer is {open_quotes}behind{close_quotes} from beginning to end. The writer normally joins the team after the programmers are well into system development and do not want to {open_quotes}waste time{close_quotes} discussing fundamentals. The writer is usually excluded from technical discussions because it is assumed that he/she would not understand anyway. Later in the system development cycle, the writer has no time to polish the documentation before a new version of the software is issued which implies that the documentation must be revised. Nevertheless, the editor/writer`s product is critical for the end-user`s appreciation of the software, a fact which promotes unity to complete the comprehensive package of software and documentation. This paper explores the planks in the bridge that spans the chasm between developers and their fundamental PR agents, the technical editors/writers. This paper defines approaches (e.g., The Circling Theory) and techniques (Bold Thrust!) employed for effective communication -- between software developer and technical writer as well as between the software and the end-user.

  11. EDITORIAL: Farewell from the outgoing Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Burnett, Keith

    2005-01-01

    I am very pleased to announce that Professor Jan-Michael Rost will be taking on the position of Editor-in-Chief at Journal of Physics B: Atomic, Molecular and Optical Physics (J. Phys. B) from the beginning of January 2005. As Editor-in-Chief I have seen the journal respond to the rapid and exciting developments in atomic, molecular and optical physics of recent years. There will, I am sure, be a great deal of new and important science in our field in the years ahead. I am also sure that Jan-Michael will do a fantastic job in guiding the journal through these times. The publishing team at J. Phys. B is a superbly responsive and effective one that does a great job in publishing the science we do. I want to thank them all for the help and support they have given me in the role of Editor-in-Chief and wish them the very best for the future. Last and certainly not least I would like to thank you, the authors, referees and readers, for making J. Phys. B such a great journal to have been a part of.

  12. CMS Configuration Editor: GUI based application for user analysis job

    NASA Astrophysics Data System (ADS)

    de Cosa, A.

    2011-12-01

    We present the user interface and the software architecture of the Configuration Editor for the CMS experiment. The analysis workflow is organized in a modular way integrated within the CMS framework that organizes in a flexible way user analysis code. The Python scripting language is adopted to define the job configuration that drives the analysis workflow. It could be a challenging task for users, especially for newcomers, to develop analysis jobs managing the configuration of many required modules. For this reason a graphical tool has been conceived in order to edit and inspect configuration files. A set of common analysis tools defined in the CMS Physics Analysis Toolkit (PAT) can be steered and configured using the Config Editor. A user-defined analysis workflow can be produced starting from a standard configuration file, applying and configuring PAT tools according to the specific user requirements. CMS users can adopt this tool, the Config Editor, to create their analysis visualizing in real time which are the effects of their actions. They can visualize the structure of their configuration, look at the modules included in the workflow, inspect the dependences existing among the modules and check the data flow. They can visualize at which values parameters are set and change them according to what is required by their analysis task. The integration of common tools in the GUI needed to adopt an object-oriented structure in the Python definition of the PAT tools and the definition of a layer of abstraction from which all PAT tools inherit.

  13. An editor's considerations in publishing industry-sponsored studies.

    PubMed

    Droller, Michael J

    2015-03-01

    The fundamental responsibility of a journal editor is to assure that studies accepted for publication provide rigorous original scientific information and reviews that are considered important to the readership. The fundamental requirements of such reports from an editor's perspective include objectivity and transparency in each of the study design, implementation of investigation methods, acquisition of data, inclusive analysis and interpretation of results, appropriate application of statistical methods, presentation of outcomes in the context of a balanced and comprehensive review of relevant literature, and meaningful conclusions. In proceeding on these presumptions, editors then have the responsibility of obtaining rigorous, objective, and constructive reviews of these reports so that they can make an unbiased decision regarding their disposition. The fundamental objective in this is to enhance the ultimate scientific validity and value of the work if and when it is accepted for publication. Guidelines have been advanced by several organizations to identify how such editorial responsibilities can be fulfilled. These guidelines also pertain to investigators, authors, and sponsors of the studies, which the various reports and reviews describe. The present article reviews these guidelines as they relate to both industry-sponsored and investigator-initiated investigations and as relevant to the variety of reports that a scientific/medical journal such as Urologic Oncology: Seminars and Original Investigations receives for publication.

  14. Statement on Publication Ethics for Editors and Publishers

    PubMed Central

    2016-01-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions. PMID:27510376

  15. PDB Editor: a user-friendly Java-based Protein Data Bank file editor with a GUI.

    PubMed

    Lee, Jonas; Kim, Sung Hou

    2009-04-01

    The Protein Data Bank file format is the format most widely used by protein crystallographers and biologists to disseminate and manipulate protein structures. Despite this, there are few user-friendly software packages available to efficiently edit and extract raw information from PDB files. This limitation often leads to many protein crystallographers wasting significant time manually editing PDB files. PDB Editor, written in Java Swing GUI, allows the user to selectively search, select, extract and edit information in parallel. Furthermore, the program is a stand-alone application written in Java which frees users from the hassles associated with platform/operating system-dependent installation and usage. PDB Editor can be downloaded from http://sourceforge.net/projects/pdbeditorjl/.

  16. The XML Metadata Editor of GFZ Data Services

    NASA Astrophysics Data System (ADS)

    Ulbricht, Damian; Elger, Kirsten; Tesei, Telemaco; Trippanera, Daniele

    2017-04-01

    Following the FAIR data principles, research data should be Findable, Accessible, Interoperable and Reuseable. Publishing data under these principles requires to assign persistent identifiers to the data and to generate rich machine-actionable metadata. To increase the interoperability, metadata should include shared vocabularies and crosslink the newly published (meta)data and related material. However, structured metadata formats tend to be complex and are not intended to be generated by individual scientists. Software solutions are needed that support scientists in providing metadata describing their data. To facilitate data publication activities of 'GFZ Data Services', we programmed an XML metadata editor that assists scientists to create metadata in different schemata popular in the earth sciences (ISO19115, DIF, DataCite), while being at the same time usable by and understandable for scientists. Emphasis is placed on removing barriers, in particular the editor is publicly available on the internet without registration [1] and the scientists are not requested to provide information that may be generated automatically (e.g. the URL of a specific licence or the contact information of the metadata distributor). Metadata are stored in browser cookies and a copy can be saved to the local hard disk. To improve usability, form fields are translated into the scientific language, e.g. 'creators' of the DataCite schema are called 'authors'. To assist filling in the form, we make use of drop down menus for small vocabulary lists and offer a search facility for large thesauri. Explanations to form fields and definitions of vocabulary terms are provided in pop-up windows and a full documentation is available for download via the help menu. In addition, multiple geospatial references can be entered via an interactive mapping tool, which helps to minimize problems with different conventions to provide latitudes and longitudes. Currently, we are extending the metadata editor

  17. Publisher's Note: ''The MaPLE device of Saha Institute of Nuclear Physics: Construction and its plasma aspects'' [Rev. Sci. Instrum. 81, 073507 (2010)

    SciTech Connect

    Pal, Rabindranath; Biswas, Subir; Basu, Subhasis; Chattopadhyay, Monobir; Basu, Debjyoti; Chaudhuri, Manis

    2010-07-15

    The Magnetized Plasma Linear Experimental (MaPLE) device is a low cost laboratory plasma device at Saha Institute of Nuclear Physics fabricated in-house with the primary aim of studying basic plasma physics phenomena such as plasma instabilities, wave propagation, and their nonlinear behavior in magnetized plasma regime in a controlled manner. The machine is specially designed to be a versatile laboratory device that can provide a number of magnetic and electric scenario to facilitate such studies. A total of 36 number of 20-turn magnet coils, designed such as to allow easy handling, is capable of producing a uniform, dc magnetic field of about 0.35 T inside the plasma chamber of diameter 0.30 m. Support structure of the coils is planned in an innovative way facilitating straightforward fabrication and easy positioning of the coils. Further special feature lies in the arrangement of the spacers between the coils that can be maneuvered rather easily to create different magnetic configurations. Various methods of plasma production can be suitably utilized according to the experimental needs at either end of the vacuum vessel. In the present paper, characteristics of a steady state plasma generated by electron cyclotron resonance method using 2.45 GHz microwave power are presented. Scans using simple probe drives revealed that a uniform and long plasma column having electron density {approx} 3-5 Multiplication-Sign 1010 cm-3 and temperature {approx} 7-10 eV, is formed in the center of the plasma chamber which is suitable for wave launching experiments.

  18. Greetings from the new Editor-in-Chief, Ronald Stambaugh Greetings from the new Editor-in-Chief, Ronald Stambaugh

    NASA Astrophysics Data System (ADS)

    Stambaugh, Ronald

    2012-04-01

    I am very pleased to join the outstanding leadership team for the journal Nuclear Fusion as Scientific Editor. The journal's high position in the field of fusion energy research derives in no small measure from the efforts of the IAEA team in Vienna, the production and marketing of IOP Publishing, the Board of Editors led by its chairman Mitsuru Kikuchi, the Associate Editor for Inertial Confinement Max Tabak and the outgoing Scientific Editor, Paul Thomas. During Paul's five year tenure submissions have grown by over 40%. The usage of the electronic journal has grown year by year with about 300 000 full text downloads of Nuclear Fusion articles in 2011, an impressive figure due in part to the launch of the full 50 year archive. High quality has been maintained while times for peer review and publishing have been reduced and the journal achieved some of the highest impact factors ever (as high as 4.27). The journal has contributed greatly to building the international scientific basis for fusion. I was privileged to serve from 2003 to 2010 as chairman of the Coordinating Committee for the International Tokamak Physics Activity (ITPA) which published in Nuclear Fusion the first ITER Physics Basis (1999) and its later update (2007). The scientific basis that has been developed to date for fusion has led to the construction of major facilities to demonstrate the production of power-plant relevant levels of fusion reactions. We look forward to the journal continuing to play a key role in the international effort toward fusion energy as these exciting major facilities and the various approaches to fusion continue to be developed. It is clear that Nuclear Fusion maintains its position in the field because of the perceived high quality of the submissions, the refereeing and the editorial processes, and the availability and utility of the online journal. The creation of the Nuclear Fusion Prize, led by the Board of Editors chairman Mitsuru Kikuchi, for the most outstanding

  19. EDITORIAL: Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Bhattacharya, P.

    2004-04-01

    On 1 January, 2004, I assumed the position of Editor-in-Chief of Journal of Physics D: Applied Physics. I will start by saying that I will do my best to justify the confidence of the journal management and publishing staff in my abilities. I was fortunate to have been able to work, as an Editorial Board member, with my predecessor, the previous Editor-in-Chief, Professor Allister Ferguson. Allister has provided a high degree of intellectual stewardship for the journal in the last five years. He has made the job appear a worthy challenge for me. I therefore take this opportunity to thank Allister on behalf of the Editorial Board and publishing staff of the journal. Several other factors contributed to my decision to accept this position. The first is the group of people who actually go about the business of publishing. The Senior Publisher, Nicola Gulley (and her predecessor Sophy Le Masurier); the Managing Editor, Jill Membrey; the Publishing Administrators, Nina Blakesley and Sarah Towell; the Production Editor, Katie Gerrard and their office staff form an amazing group and have managed to make the operation of the journal incredibly efficient. An index of this is the speed with which incoming manuscripts are processed. The average time between the receipt of a manuscript and its web publication, if accepted, is 130 days. This is three to five times shorter than for most other journals. A factor that contributes to this success is a responsive pool of referees that the publishing staff have as a valuable resource. Ultimately, the standard bearers of any journal are the referees. Therefore, a grateful `thank you' is due from all of us at J. Phys. D to all our referees, who diligently perform this honourable task. The Associate Editors of the journal, Professors Lawler, Margaritondo and O'Grady, also provide immense scientific leadership. They help in defining new directions for the journal and in the publishing process. Last, but not least, a remarkable asset of

  20. Problems faced by editors of peer reviewed medical journals.

    PubMed

    Jawaid, Shaukat A

    2004-01-01

    Forty-six medical and dental journals are published from Pakistan of which only 29 are currently recognized by the Pakistan Medical and Dental Council. Only a few are peer reviewed. Six are indexed in Medline while EMBASE Excerpta Medica and World Health Organization Index Medicus for Eastern Mediterranean Region cover others. Editors of the peer reviewed medical journals are faced with numerous problems, which relate to the authors. Some of these are: shortage of quality of manuscripts, poor quality of reviewers, problems with indexation in international indexing services particularly Medline, duplicate submission and authorship and lastly, financial problems. Patronage from the Pharma industry is the major source of revenue which itself has serious implications. Editing a medical journal is a very stressful job and the editors have to work under too many pressures. A lot of useful data is presented at medical conferences, but a vast majority of it remains unpublished for various reasons, which adversely affects the citation rate from scientists from the developing third world countries in the world of medical literature. A few lectures on medical writing and research methodology to final year medical students will expose them to the art of medical writing. Specialty organizations can be persuaded to have a session on medical writing at their conferences, which will be extremely helpful not only to the potential new authors but also others, thereby improving the quality of their manuscripts. In addition to regular seminars, workshops for authors, reviewers and training courses for editors, subscribing to local medical journals by healthcare professionals and libraries are some of the measures that will help improve the situation to a great extent.

  1. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Nielsch, Kornelius

    2012-01-01

    On 1 January 2012 I will be assuming the position of Editor-in-Chief of the journal Semiconductor Science and Technology (SST). I am flattered by the confidence expressed in my ability to carry out this challenging job and I will try hard to justify this confidence. The previous Editor-in-Chief, Laurens Molenkamp, University of Würzburg, Germany, has worked tirelessly for the last ten years and has done an excellent job for the journal. Everyone at the journal is profoundly grateful for his leadership and for his achievements In 2012 several new members will join the Editorial Board: Professor Deli Wang (University of California, San Diego) with considerable expertise in semiconductor nanowires, Professor Saskia Fischer (Humboldt University, Berlin, Germany) with a background in semiconductor quantum devices, and Professor Erwin Kessels (Eindhoven University of Technology, Netherlands) with extensive experience in plasma processing of thin films and gate oxides. In particular, I want to express my gratitude to Professor Israel Bar-Joseph (Weizmann Institute of Science, Israel) and Professor Maria Tamargo (The City College of New York, USA), who will leave next year and who have vigorously served the Editorial Board for years. The journal has recently introduced a fast-track option for manuscripts. This option is a high-quality, high-profile outlet for new and important research across all areas of semiconductor research. Authors can expect to receive referee reports in less than 20 days from submission. Once accepted, you can expect the articles to be online within two or three weeks from acceptance and to be published in print in less than a month. Furthermore, all fast-track communications published in 2011 will be free to read for ten years. More detailed information on fast-track publication can be found on the following webpage: http://iopscience.iop.org/0268-1242/page/Fast track communications It is encouraging to see that since the journal introduced pre

  2. An Algebraic Specification Language and a Syntax Directed Editor.

    DTIC Science & Technology

    1984-12-01

    the various parts of specification produced by the language and describes an experimental syntax directed editor which uses the language’s grammar .. N...y t he ldngua ;ke aL>: describes an experimental syntax iirected eiitic w..icil~~s. the language’s grammar . 4 N 71 1ABLE OF CC4TENTS " i1TRODJCTION...zfinai _Lcif_;a.ioa. explandtion, of the neta-sym-hols useLd to ioco.cc teri-ia± * strings ir. the grammar are as fcliows: < > - A iname enclosed by

  3. Collective Text Editor: A New Interface Focused on Interaction Design

    NASA Astrophysics Data System (ADS)

    Behar, Patricia Alejandra; Macedo, Alexandra Lorandi; Passos, Jaire Ederson; Passos, Paula Caroline Schifino Jardim

    The Collective Text Editor ETC is a tool that follows Web 2.0 philosophy. Thus, its aim is to foster collaborative work mediated by computer and to create a space where the synchronous and asynchronous construction of collective texts among geographically dispersed users can be encouraged. The ETC is linked to a research project of NUTED/UFRGS. The present article deals with the reconstruction of the interface so as to adapt it to the current technological demands, giving it credibility and new personality.

  4. EDITORIAL: Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Garcia, Ephrahim

    2008-02-01

    I am Professor Ephrahim Garcia, an Associate Professor at Sibley School of Mechanical and Aerospace Engineering at Cornell University in Ithaca, New York. I have been at Cornell University since 2002, spent four years as a Program Manager at the Defense Advanced Research Project Agency from 1998-2002, and before that seven years at the Department of Mechanical Engineering at Vanderbilt University in Nashville, Tennessee. I have served on the Editorial Advisory Board of Smart Materials and Structures (SMS) for the last six years. It is a humbling thing to be asked to take up the post of Editor-in-Chief in a field with so many talented researchers. I would like to say a heartfelt thanks to the members of the Editorial Board and IOP Publishing for their confidence in me. Most importantly, I would like to thank Professor Vijay Varadan of the University of Arkansas and Professor Richard Claus of Virginia Polytechnic Institute and State University for their efforts in launching the journal 16 years ago. They have been stewards, promoters and, especially Vijay, key to the operation and function of SMS for all these years, and our research community is indebted to them. Professors Varadan and Claus have dedicated their careers to the area of smart materials and structures and we are very grateful for their leadership, mentoring and contribution. SMS is a thriving journal offering papers on all technical areas concerned with smart materials, systems and structures from the micro- and nanoscale to the macroscale. The journal is undergoing some major changes, including the recent transferal of papers to IOP Publishing's peer-review management system. With this new system authors can expect fast publication times of around 4 or 5 months from submission, and excellent author service. In this world of ever changing technology, the Editorial Board and I aim to reduce the time to publication for researchers in this exciting area of science and engineering. I am in the process of

  5. JGR-Solid Earth and Planets editor Kenneth A. Hoffman

    NASA Astrophysics Data System (ADS)

    Enhancing the presence of geomagnetism and paleomagnetism in the Journal of Geophysical Research—Solid Earth and Planets is a principal goal for Ken Hoffman during his tenure as an editor of the journal. “Many researchers in paleomagnetism and rock magnetism tend to spread their publications among several journals,” Hoffman said, “perhaps having the mistaken impression that JGR may not always be the appropriate choice for their work.” Hoffman wants to alter this image of JGR, and he extends an open invitation for all significant contributions on topics in geomagnetism and paleomagnetism.

  6. Editorial independence at medical journals owned by professional associations: a survey of editors.

    PubMed

    Davis, Ronald M; Müllner, Marcus

    2002-10-01

    The purpose of this study was to assess the degree of editorial independence at a sample of medical journals and the relationship between the journals and their owners. We surveyed the editors of 33 medical journals owned by not-for-profit organizations ("associations"), including 10 journals represented on the International Committee of Medical Journal Editors (nine of which are general medical journals) and a random sample of 23 specialist journals with high impact factors that are indexed by the Institute for Scientific Information. The main outcome measures were the authority to hire, fire, and oversee the work of the editor; the editor's tenure and financial compensation; control of the journal's budget; publication of material about the association; and the editor's perceptions about editorial independence and pressure over editorial content. Of the 33 editors, 23 (70%) reported having complete editorial freedom, and the remainder reported a high level of freedom (a score of > or = 8, where 10 equals complete editorial freedom and 1 equals no editorial freedom). Nevertheless, a substantial minority of editors reported having received at least some pressure in recent years over editorial content from the association's leadership (42%), senior staff (30%), or rank-and-file members (39%). The association's board of directors has the authority to hire (48%) or fire (55%) the editor for about half of the journals, and the editor reports to the board for 10 journals (30%). Twenty-three editors (70%) are appointed for a specific term (median term = 5 years). Three-fifths of the journals have no control over their profit, and the majority of journals use the association's legal counsel and/or media relations staff. Stronger safeguards are needed to give editors protection against pressure over editorial content, including written guarantees of editorial freedom and governance structures that support those guarantees. Strong safeguards are also needed because editors

  7. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

  8. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

  9. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

  10. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

  11. 29 CFR 793.8 - “News editor.”

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false âNews editor.â 793.8 Section 793.8 Labor Regulations... Exemption § 793.8 “News editor.” A news editor is an employee who gathers, edits and rewrites the news. He may also select and prepare news items for broadcast and present the news on the air. An employee who...

  12. Gene targeting, genome editing: from Dolly to editors.

    PubMed

    Tan, Wenfang; Proudfoot, Chris; Lillico, Simon G; Whitelaw, C Bruce A

    2016-06-01

    One of the most powerful strategies to investigate biology we have as scientists, is the ability to transfer genetic material in a controlled and deliberate manner between organisms. When applied to livestock, applications worthy of commercial venture can be devised. Although initial methods used to generate transgenic livestock resulted in random transgene insertion, the development of SCNT technology enabled homologous recombination gene targeting strategies to be used in livestock. Much has been accomplished using this approach. However, now we have the ability to change a specific base in the genome without leaving any other DNA mark, with no need for a transgene. With the advent of the genome editors this is now possible and like other significant technological leaps, the result is an even greater diversity of possible applications. Indeed, in merely 5 years, these 'molecular scissors' have enabled the production of more than 300 differently edited pigs, cattle, sheep and goats. The advent of genome editors has brought genetic engineering of livestock to a position where industry, the public and politicians are all eager to see real use of genetically engineered livestock to address societal needs. Since the first transgenic livestock reported just over three decades ago the field of livestock biotechnology has come a long way-but the most exciting period is just starting.

  13. An editor for the generation and customization of geometry restraints

    DOE PAGES

    Moriarty, Nigel W.; Draizen, Eli J.; Adams, Paul D.

    2017-02-01

    Chemical restraints for use in macromolecular structure refinement are produced by a variety of methods, including a number of programs that use chemical information to generate the required bond, angle, dihedral, chiral and planar restraints. These programs help to automate the process and therefore minimize the errors that could otherwise occur if it were performed manually. Furthermore, restraint-dictionary generation programs can incorporate chemical and other prior knowledge to provide reasonable choices of types and values. However, the use of restraints to define the geometry of a molecule is an approximation introduced with efficiency in mind. The representation of a bondmore » as a parabolic function is a convenience and does not reflect the true variability in even the simplest of molecules. Another complicating factor is the interplay of the molecule with other parts of the macromolecular model. Finally, difficult situations arise from molecules with rare or unusual moieties that may not have their conformational space fully explored. These factors give rise to the need for an interactive editor for WYSIWYG interactions with the restraints and molecule. Restraints Editor, Especially Ligands (REEL) is a graphical user interface for simple and error-free editing along with additional features to provide greater control of the restraint dictionaries in macromolecular refinement.« less

  14. Making a height field editor for WireMan

    SciTech Connect

    Cano, J.

    1994-04-01

    The focus of this project is to modify and write new code for a program named WireMan. WireMan draws in 3-D using items from a menu (cones, spheres, etc.). One of the items which can be selected is called the height field. The height field, as it currently appears in WireMan, is a 3-D graph of a set equation. Originally, the height field was supposed to be able to display any curve the user may need. However, because of lack of time and programmers, the height field was never completed and has remained at this constant curve since its creation. To change it a user needs to modify progra mcode, thus, a height field editor is necessary. Through the editor, the user will be able to modify the height field by either equation of matrix. The latter will allow the user to determine a curve for the height field according to matrix or grid entries (of the form n x n, where up to 10 x 10 entries can be made). The grid will then be stretched and evaluated over the height field plane (which consists of 512-512 generated entries) and the curve will then be generated. The difficulties and the results of the project are outlined according to their occurrences throughout the paper.

  15. An editor for the generation and customization of geometry restraints

    PubMed Central

    Moriarty, Nigel W.; Adams, Paul D.

    2017-01-01

    Chemical restraints for use in macromolecular structure refinement are produced by a variety of methods, including a number of programs that use chemical information to generate the required bond, angle, dihedral, chiral and planar restraints. These programs help to automate the process and therefore minimize the errors that could otherwise occur if it were performed manually. Furthermore, restraint-dictionary generation programs can incorporate chemical and other prior knowledge to provide reasonable choices of types and values. However, the use of restraints to define the geometry of a molecule is an approximation introduced with efficiency in mind. The representation of a bond as a parabolic function is a convenience and does not reflect the true variability in even the simplest of molecules. Another complicating factor is the interplay of the molecule with other parts of the macromolecular model. Finally, difficult situations arise from molecules with rare or unusual moieties that may not have their conformational space fully explored. These factors give rise to the need for an interactive editor for WYSIWYG interactions with the restraints and molecule. Restraints Editor, Especially Ligands (REEL) is a graphical user interface for simple and error-free editing along with additional features to provide greater control of the restraint dictionaries in macromolecular refinement. PMID:28177308

  16. A Generic Metadata Editor Supporting System Using Drupal CMS

    NASA Astrophysics Data System (ADS)

    Pan, J.; Banks, N. G.; Leggott, M.

    2011-12-01

    Metadata handling is a key factor in preserving and reusing scientific data. In recent years, standardized structural metadata has become widely used in Geoscience communities. However, there exist many different standards in Geosciences, such as the current version of the Federal Geographic Data Committee's Content Standard for Digital Geospatial Metadata (FGDC CSDGM), the Ecological Markup Language (EML), the Geography Markup Language (GML), and the emerging ISO 19115 and related standards. In addition, there are many different subsets within the Geoscience subdomain such as the Biological Profile of the FGDC (CSDGM), or for geopolitical regions, such as the European Profile or the North American Profile in the ISO standards. It is therefore desirable to have a software foundation to support metadata creation and editing for multiple standards and profiles, without re-inventing the wheels. We have developed a software module as a generic, flexible software system to do just that: to facilitate the support for multiple metadata standards and profiles. The software consists of a set of modules for the Drupal Content Management System (CMS), with minimal inter-dependencies to other Drupal modules. There are two steps in using the system's metadata functions. First, an administrator can use the system to design a user form, based on an XML schema and its instances. The form definition is named and stored in the Drupal database as a XML blob content. Second, users in an editor role can then use the persisted XML definition to render an actual metadata entry form, for creating or editing a metadata record. Behind the scenes, the form definition XML is transformed into a PHP array, which is then rendered via Drupal Form API. When the form is submitted the posted values are used to modify a metadata record. Drupal hooks can be used to perform custom processing on metadata record before and after submission. It is trivial to store the metadata record as an actual XML file

  17. Science journal editors' views on publication ethics: results of an international survey.

    PubMed

    Wager, E; Fiack, S; Graf, C; Robinson, A; Rowlands, I

    2009-06-01

    Breaches of publication ethics such as plagiarism, data fabrication and redundant publication are recognised as forms of research misconduct that can undermine the scientific literature. We surveyed journal editors to determine their views about a range of publication ethics issues. Questionnaire sent to 524 editors-in-chief of Wiley-Blackwell science journals asking about the severity and frequency of 16 ethical issues at their journals, their confidence in handling such issues, and their awareness and use of guidelines. Responses were obtained from 231 editors (44%), of whom 48% edited healthcare journals. The general level of concern about the 16 issues was low, with mean severity scores of <1 (on a scale of 0-3) for all but one. The issue of greatest concern (mean score 1.19) was redundant publication. Most editors felt confident in handling the issues, with <15% feeling "not at all confident" for all but one of the issues (gift authorship, 22% not confident). Most editors believed such problems occurred less than once a year and >20% of the editors stated that 12 of the 16 items never occurred at their journal. However, 13%-47% did not know the frequency of the problems. Awareness and use of guidelines was generally low. Most editors were unaware of all except other journals' instructions. Most editors of science journals seem not very concerned about publication ethics and believe that misconduct occurs only rarely in their journals. Many editors are unfamiliar with available guidelines but would welcome more guidance or training.

  18. Improving systems documentation using an online copy editor

    SciTech Connect

    Kahn, R.L.

    1985-01-01

    For the last three years the author has been using Writers Workbench, a UNIX text-editing tool, to edit computer documentation. In this article the author outlines his experiences using the system, noting both the advantages to explore and pitfalls to avoid in using this tool. Writers Workbench is especially useful for improving a writer's basic skills - punctuation, spelling, and grammar. When used effectively, Writers Workbench can cut down on wordiness and improve the consistency of a manual. It can help in the creation of a table of contents, index, glossary, and bibliography and in checking readability. Furthermore, by creating user-defined dictionaries, authors or editors can customize the tool to fit their purposes and styles. However, Writers Workbench is not good at catching problems relating to organization, focus, and clarity.

  19. Highlighting impact: Do editors' selections identify influential papers?

    NASA Astrophysics Data System (ADS)

    Antonoyiannakis, Manolis

    A recent trend in scientific publishing is that journal editors highlight each week a select set among the papers published (usually) in their respective journals. The highlighted papers are deemed of higher quality, importance, or interest than the 'average' paper and feature prominently in the publishers' websites. We perform a citation analysis of the highlighted papers for a number of journals from various publishers in physics. By comparing the performance of highlighted papers relative to (a) typical papers and (b) highly cited papers in their source journals and in other journals in the field, we explore whether, and to what extent, the selection process at the time of publication identifies papers that will turn out to be influential. We discuss the broader implications for research assessment.

  20. A diagram editor for efficient biomedical knowledge capture and integration.

    PubMed

    Yu, Bohua; Jakupovic, Elvis; Wilson, Justin; Dai, Manhong; Xuan, Weijian; Mirel, Barbara; Athey, Brian; Watson, Stanley; Meng, Fan

    2008-03-01

    Understanding the molecular mechanisms underlying complex disorders requires the integration of data and knowledge from different sources including free text literature and various biomedical databases. To facilitate this process, we created the Biomedical Concept Diagram Editor (BCDE) to help researchers distill knowledge from data and literature and aid the process of hypothesis development. A key feature of BCDE is the ability to capture information with a simple drag-and-drop. This is a vast improvement over manual methods of knowledge and data recording and greatly increases the efficiency of the biomedical researcher. BCDE also provides a unique concept matching function to enforce consistent terminology, which enables conceptual relationships deposited by different researchers in the BCDE database to be mined and integrated for intelligible and useful results. We hope BCDE will promote the sharing and integration of knowledge from different researchers for effective hypothesis development.

  1. Upcoming IJTMB Initiatives from the Interim Executive Editor

    PubMed Central

    Kennedy, Ann Blair

    2016-01-01

    It is an honor and a privilege to be appointed the Interim Executive Editor for the IJTMB; I am lucky to have some initiatives that were already in development by the previous editorial team that I hope to bring to fruition over the next few months. First, I hope to increase the Journal’s Internet presence through social media to expand readership and encourage new submitters. The second initiative is a mentoring program to assist writers with their submissions to the Journal. Finally, I, and the rest of the editorial staff, will continue to evaluate the process, procedures, and forms used in peer review. I hope to move these initiatives forward and by doing so, bring in new readers, submitters, and reviewers to the Journal. PMID:27974945

  2. Educating science editors: is there a comprehensive strategy?

    PubMed Central

    Gasparyan, Armen Yuri; Yessirkepov, Marlen; Gorin, Sergey V.; Kitas, George D.

    2014-01-01

    The article considers available options to educate science editors in the fast-transforming digital environment. There is no single course or resource that can cover their constantly changing and diversifying educational needs. The involvement in research, writing, and reviewing is important for gaining editing skills, but that is not all. Membership in editorial associations and access to updated scholarly information in the field are mandatory for maintaining editorial credentials. Learned associations offer access to a few widely-recognized periodicals. There are also formal training courses covering issues in science writing and ethical editing, but no high-level evidence data exist to promote any of these. Networking with like-minded specialists within the global and regional editorial associations seems a useful strategy to upgrade editorial skills and resolve problems with the quality control and digitization of scholarly periodicals. PMID:25559840

  3. The X-windows interactive navigation data editor

    NASA Technical Reports Server (NTRS)

    Rinker, G. C.

    1992-01-01

    A new computer program called the X-Windows Interactive Data Editor (XIDE) was developed and demonstrated as a prototype application for editing radio metric data in the orbit-determination process. The program runs on a variety of workstations and employs pull-down menus and graphical displays, which allow users to easily inspect and edit radio metric data in the orbit data files received from the Deep Space Network (DSN). The XIDE program is based on the Open Software Foundation OSF/Motif Graphical User Interface (GUI) and has proven to be an efficient tool for editing radio metric data in the navigation operations environment. It was adopted by the Magellan Navigation Team as their primary data-editing tool. Because the software was designed from the beginning to be portable, the prototype was successfully moved to new workstation environments. It was also itegrated into the design of the next-generation software tool for DSN multimission navigation interactive launch support.

  4. An Internet-based ontology editor for medical appropriateness criteria.

    PubMed

    Kahn, C E

    1998-04-01

    Appropriateness criteria and practice guidelines seek to promote the cost-effectiveness use of medical interventions, and can be most useful when integrated with computer-based patient records and order-entry systems. Building an abstract model (ontology) of appropriateness criteria can require considerable effort among investigators at geographically dispersed institutions. To facilitate the construction and maintenance of ontologies for clinical appropriateness criteria, the author developed an Internet-based system for viewing and editing the knowledge model. The system, called NEON (Network-based Editor for ONtologies), uses the World Wide Web as a platform-independent user interface. NEON allows users to edit the indexing terms and the semantic network that form the ontology for a set of appropriateness criteria. Ontologies built using the system can be imported and exported using an open, internationally standardized format based on the Standard Generalized Markup Language (SGML).

  5. Andreae is New Editor of Global Biogeochemical Cycles

    NASA Astrophysics Data System (ADS)

    Andreae, Meinrat O.

    2004-10-01

    As the incoming editor of Global Biogeochemical Cycles, I would like to introduce myself and my ideas for the journal to Eos readers and to current and potential GBC authors. I've had a somewhat ``roaming'' scientific evolution, coming from ``straight'' chemistry through hard-rock geochemistry to chemical oceanography, the field in which I did my Ph.D. I taught marine chemistry at Florida State University for a number of years, and developed an interest in ocean/atmosphere interactions and atmospheric chemistry. In 1987 I took on my present job at the Max Planck Institute for Chemistry, in Mainz, Germany, and, after leaving the seacoast, my interests shifted to interactions between the terrestrial biosphere and atmosphere, including the role of vegetation fires. My present focus is on the role of biogenic aerosols and biomass smoke in regulating cloud properties and influencing climate.

  6. Advanced software development workstation project: Engineering scripting language. Graphical editor

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Software development is widely considered to be a bottleneck in the development of complex systems, both in terms of development and in terms of maintenance of deployed systems. Cost of software development and maintenance can also be very high. One approach to reducing costs and relieving this bottleneck is increasing the reuse of software designs and software components. A method for achieving such reuse is a software parts composition system. Such a system consists of a language for modeling software parts and their interfaces, a catalog of existing parts, an editor for combining parts, and a code generator that takes a specification and generates code for that application in the target language. The Advanced Software Development Workstation is intended to be an expert system shell designed to provide the capabilities of a software part composition system.

  7. EDITORIAL: A word from the new Editor-in-Chief A word from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Mostowski, Jan

    2011-01-01

    TIn the autumn of 2010 I became the Editor-in Chief of European Journal of Physics (EJP). EJP is a place for teachers, instructors and professors to exchange their views on teaching physics at university level and share their experience. It is general opinion that no good research is possible without connection with good, high-quality teaching, at the university level in particular. Therefore excellence in physics teaching is important to the physics community. European Journal of Physics is proud of its contribution to achieving this goal. As Editor-in-Chief, I will continue to work to this general objective of the journal. We will publish articles on specific topics in physics, stressing originality of presentation and suitability for use in students'laboratories, lectures and physics teaching in general. We will also publish more pedagogical papers presenting the achievements of particular teaching methods. In addition, we will continue to publish special sections on particular areas of physics, as well as the annual special section on physics competitions. European Journal of Physics is in good shape. Due to the work of the previous editors and the publisher, the readership is high and growing steadily, and many excellent papers are being submitted and published. I hope that this positive trend for the journal will continue, and I will do my best to keep to this high standard. A few words about myself. I work in the Institute of Physics in Warsaw, Poland. My main research interests are in theoretical quantum optics and I have published about 80 research papers on this topic. For many years I was involved in teaching physics at university and in high school. I am a co-author of a textbook on physics for high-school students and of a problem book in quantum mechanics. For the last ten years, I have been involved in the International Physics Olympiad and over the last few years I have been a member of the Editorial Board of European Journal of Physics.

  8. A "Situational" and "Coorientational" Measure of Specialized Magazine Editors' Perceptions of Readers.

    ERIC Educational Resources Information Center

    Jeffers, Dennis W.

    A study was undertaken of specialized magazine editors' perceptions of audience characteristics as well as the perceived role of their publications. Specifically, the study examines the relationship between the editors' perceptions of reader problem recognition, level of involvement, constraint recognition, and possession of reference criteria and…

  9. Editorial Page Editors and Endorsements: Chain-owned vs. Independent Newspapers.

    ERIC Educational Resources Information Center

    St. Dizier, Byron

    Questionnaires were sent to 114 of the 228 editorial page editors at newspapers in the United States with daily circulations greater than 50,000 for a study that compared (1) the editor-publisher relationship existing at chains to that found at independent papers, and (2) the 1984 presidential endorsements made by chains to those by independent…

  10. Error Pattern Analysis Applied to Technical Writing: An Editor's Guide for Writers.

    ERIC Educational Resources Information Center

    Monagle, E. Brette

    The use of error pattern analysis can reduce the time and money spent on editing and correcting manuscripts. What is required is noting, classifying, and keeping a frequency count of errors. First an editor should take a typical page of writing and circle each error. After the editor has done a sufficiently large number of pages to identify an…

  11. Debunking the Mutilated Boy: A Study of Newspaper Editors and an Inflammatory Rumor.

    ERIC Educational Resources Information Center

    Brown, Lee

    A study examined how newspaper editors resolve issues relating to rumors--that is whether to cover stories which may turn out to be false. The "mutilated boy" rumor was chosen for its antiquity and endurance, its powerful theme, and its ability to create intense anxiety in a community. Thirty-three of the 86 editors who responded to the…

  12. A Coorientational Study of Food Public Relations Practitioners, Editors and Readers.

    ERIC Educational Resources Information Center

    Knodell, Joyce Elaine

    Survey data on newspaper food editors and newspaper readers were collected through a title-rating technique. Analysis of responses to 40 food titles and leads indicated three newspaper food-editor types: transitional, traditional, and "new guard." Food-page readers fell into two types: information oriented (nutritionists) and cooking…

  13. "Clones," Codes, and Conflicts of Interest in Cartooning: Cartoonists and Editors Look at Ethics.

    ERIC Educational Resources Information Center

    Riffe, Daniel; And Others

    A study examined differences between political cartoonists and op-ed page editors on both traditional ethical issues (such as conflicts of interest) and the special, style-related concerns of editorial cartoonists. Hypotheses proposed were that editors and cartoonists (1) would condemn "cloning" or copying, reflecting an ethical…

  14. A "Situational" and "Coorientational" Measure of Specialized Magazine Editors' Perceptions of Readers.

    ERIC Educational Resources Information Center

    Jeffers, Dennis W.

    A study was undertaken of specialized magazine editors' perceptions of audience characteristics as well as the perceived role of their publications. Specifically, the study examines the relationship between the editors' perceptions of reader problem recognition, level of involvement, constraint recognition, and possession of reference criteria and…

  15. Letter to the editor of TAAP, in response to letter from Anders et al.

    EPA Science Inventory

    To the Editor, Toxicology and Applied Pharmacology: We would like to address the letter to the editor submitted by Anders et al. regarding the substantive issues raised regarding our paper "Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physi...

  16. The Editor and Publisher as Public Official: The Ultimate Conflict of Interest.

    ERIC Educational Resources Information Center

    Sneed, Don

    A fifteen-item Likert scale and indepth personal interviews were used to collect data in a study that examined whether five individuals who held both the role of editor and public official were perceived as able to perform in a socially responsible manner as editors of their community newspapers in their estimation and in the estimation of a…

  17. Beacon Editor: Capturing Signal Transduction Pathways Using the Systems Biology Graphical Notation Activity Flow Language.

    PubMed

    Elmarakeby, Haitham; Arefiyan, Mostafa; Myers, Elijah; Li, Song; Grene, Ruth; Heath, Lenwood S

    2017-08-28

    The Beacon Editor is a cross-platform desktop application for the creation and modification of signal transduction pathways using the Systems Biology Graphical Notation Activity Flow (SBGN-AF) language. Prompted by biologists' requests for enhancements, the Beacon Editor includes numerous powerful features for the benefit of creation and presentation.

  18. A survey of orthopaedic journal editors determining the criteria of manuscript selection for publication

    PubMed Central

    2011-01-01

    Background To investigate the characteristics of editors and criteria used by orthopaedic journal editors in assessing submitted manuscripts. Methods Between 2008 to 2009 all 70 editors of Medline listed orthopaedic journals were approached prospectively with a questionnaire to determine the criteria used in assessing manuscripts for publication. Results There was a 42% response rate. There was 1 female editor and the rest were male with 57% greater than 60 years of age. 67% of the editors worked in university teaching hospitals and 90% of publications were in English. The review process differed between journals with 59% using a review proforma, 52% reviewing an anonymised manuscript, 76% using a routine statistical review and 59% of journals used 2 reviewers routinely. In 89% of the editors surveyed, the editor was able to overrule the final decision of the reviewers. Important design factors considered for manuscript acceptance were that the study conclusions were justified (80%), that the statistical analysis was appropriate (76%), that the findings could change practice (72%). The level of evidence (70%) and type of study (62%) were deemed less important. When asked what factors were important in the manuscript influencing acceptance, 73% cited an understandable manuscript, 53% cited a well written manuscript and 50% a thorough literature review as very important factors. Conclusions The editorial and review process in orthopaedic journals uses different approaches. There may be a risk of language bias among editors of orthopaedic journals with under-representation of non-English publications in the orthopaedic literature. PMID:21527007

  19. Editorial Page Editors and Endorsements: Chain-owned vs. Independent Newspapers.

    ERIC Educational Resources Information Center

    St. Dizier, Byron

    Questionnaires were sent to 114 of the 228 editorial page editors at newspapers in the United States with daily circulations greater than 50,000 for a study that compared (1) the editor-publisher relationship existing at chains to that found at independent papers, and (2) the 1984 presidential endorsements made by chains to those by independent…

  20. Letter to the editor of TAAP, in response to letter from Anders et al.

    EPA Science Inventory

    To the Editor, Toxicology and Applied Pharmacology: We would like to address the letter to the editor submitted by Anders et al. regarding the substantive issues raised regarding our paper "Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physi...

  1. Magazine Article Placement: How Editors, Regular Contributors, and Novice Writers Rate Query Letters.

    ERIC Educational Resources Information Center

    Jolliffe, Lee

    About 350,000 freelance magazine articles were purchased by magazine editors last year from the 22,000 freelancers and 225,000 would-be freelancers in the United States. A study examined the factors editors judge most important in selecting freelance magazine article proposals, using factor analysis and qualitative examination of persuasive…

  2. New Technology and the Writer/Editor Relationship: Shifting Electronic Realities.

    ERIC Educational Resources Information Center

    Endres, Kathleen L.; Schierhorn, Ann B.

    1995-01-01

    Examines the role new technology is playing in the magazine writer/editor relationship. Finds that editors report the new technology is affecting their relationship with writers, and that free-lancers are less apt to use expensive new technology than staff writers. (SR)

  3. Self-Interest and Scholarly Publication: The Dilemma of Researchers, Reviewers, and Editors

    ERIC Educational Resources Information Center

    Calabrese, Raymond L.; Roberts, Brian

    2004-01-01

    Academic misconduct in research is of growing concern to funding agencies, scholars, and academic journal editors. Scholarly publication has ethical implications researchers, reviewers, and journal editors. The theoretical background of the ethics of scholarly publication is explored as well as the use of a case study of an untenured researcher…

  4. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  5. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  6. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  7. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Combination announcer, news editor and chief engineer. 793...)(9) OF THE FAIR LABOR STANDARDS ACT Requirements for Exemption § 793.11 Combination announcer, news... as a news editor. In such cases, the primary employment test under the section 13(b)(9) exemption...

  8. Dr. Bruce Squires witnessed vast changes during tenure as CMAJ editor

    PubMed Central

    Sullivan, Patrick

    1996-01-01

    Dr. Bruce Squires retired in September after spending 10 years as editor of CMAJ. During his tenure the editor's responsibilities expanded greatly because of the CMA's foray into the publishing of medical books and additional journals and other publications. In this article, people who have worked with Squires reflect on his term with CMAJ. Imagesp570-a

  9. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    ERIC Educational Resources Information Center

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published…

  10. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    ERIC Educational Resources Information Center

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published…

  11. THE NEW ONLINE METADATA EDITOR FOR GENERATING STRUCTURED METADATA

    SciTech Connect

    Devarakonda, Ranjeet; Shrestha, Biva; Palanisamy, Giri; Hook, Leslie A; Killeffer, Terri S; Boden, Thomas A; Cook, Robert B; Zolly, Lisa; Hutchison, Viv; Frame, Mike; Cialella, Alice; Lazer, Kathy

    2014-01-01

    Nobody is better suited to describe data than the scientist who created it. This description about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset [1]. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [2][4]. OME is part of ORNL s Mercury software fleet [2][3]. It was jointly developed to support projects funded by the United States Geological Survey (USGS), U.S. Department of Energy (DOE), National Aeronautics and Space Administration (NASA) and National Oceanic and Atmospheric Administration (NOAA). OME s architecture provides a customizable interface to support project-specific requirements. Using this new architecture, the ORNL team developed OME instances for USGS s Core Science Analytics, Synthesis, and Libraries (CSAS&L), DOE s Next Generation Ecosystem Experiments (NGEE) and Atmospheric Radiation Measurement (ARM) Program, and the international Surface Ocean Carbon Dioxide ATlas (SOCAT). Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. From the information on the form, the Metadata Editor can create an XML file on the server that the editor is installed or to the user s personal computer. Researchers can also use the ORNL Metadata Editor to modify existing XML metadata files. As an example, an NGEE Arctic scientist use OME to register

  12. The New Online Metadata Editor for Generating Structured Metadata

    NASA Astrophysics Data System (ADS)

    Devarakonda, R.; Shrestha, B.; Palanisamy, G.; Hook, L.; Killeffer, T.; Boden, T.; Cook, R. B.; Zolly, L.; Hutchison, V.; Frame, M. T.; Cialella, A. T.; Lazer, K.

    2014-12-01

    Nobody is better suited to "describe" data than the scientist who created it. This "description" about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [1] [2]. Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. How is OME helping Big Data Centers like ORNL DAAC? The ORNL DAAC is one of NASA's Earth Observing System Data and Information System (EOSDIS) data centers managed by the ESDIS Project. The ORNL DAAC archives data produced by NASA's Terrestrial Ecology Program. The DAAC provides data and information relevant to biogeochemical dynamics, ecological data, and environmental processes, critical for understanding the dynamics relating to the biological components of the Earth's environment. Typically data produced, archived and analyzed is at a scale of multiple petabytes, which makes the discoverability of the data very challenging. Without proper metadata associated with the data, it is difficult to find the data you are looking for and equally difficult to use and understand the data. OME will allow data centers like the ORNL DAAC to produce meaningful, high quality, standards-based, descriptive information about their data products in-turn helping with the data discoverability and

  13. Medical journal editors lacked familiarity with scientific publication issues despite training and regular exposure.

    PubMed

    Wong, Victoria S S; Callaham, Michael L

    2012-03-01

    To characterize medical editors by determining their demographics, training, potential sources of conflict of interest (COI), and familiarity with ethical standards. We selected editors of clinical medical journals with the highest annual citation rates. One hundred eighty-three editors were electronically surveyed (response rate, 52%) on demographics and experiences with editorial training, publication ethics, industry, and scientific publication organizations. Editors reported formal (76%) and informal (89%) training in medical editing topics. Most editors saw publication ethics issues (e.g., authorship, COIs) at least once a year. When presented with four questions about editorial issues discussed in commonly cited authoritative policy sources, performance was poor on topics of authorship (30% answered correctly), COI (15%), peer review (16%), and plagiarism (17%). Despite this, confidence level in editorial skills on a Likert scale from the beginning to the end of the survey dropped only slightly from 4.2 to 3.9 (P<0.0001). Our study presents a current look at editors of major clinical medical journals. Most editors reported training in medical editing topics, saw ethical issues regularly, and were aware of scientific publication organizations, but their knowledge of four common and well-disseminated publication ethics topics appears poor. Copyright © 2012 Elsevier Inc. All rights reserved.

  14. Consed: a graphical editor for next-generation sequencing.

    PubMed

    Gordon, David; Green, Phil

    2013-11-15

    The rapid growth of DNA sequencing throughput in recent years implies that graphical interfaces for viewing and correcting errors must now handle large numbers of reads, efficiently pinpoint regions of interest and automate as many tasks as possible. We have adapted consed to reflect this. To allow full-feature editing of large datasets while keeping memory requirements low, we developed a viewer, bamScape, that reads billion-read BAM files, identifies and displays problem areas for user review and launches the consed graphical editor on user-selected regions, allowing, in addition to longstanding consed capabilities such as assembly editing, a variety of new features including direct editing of the reference sequence, variant and error detection, display of annotation tracks and the ability to simultaneously process a group of reads. Many batch processing capabilities have been added. The consed package is free to academic, government and non-profit users, and licensed to others for a fee by the University of Washington. The current version (26.0) is available for linux, macosx and solaris systems or as C++ source code. It includes a user's manual (with exercises) and example datasets. http://www.phrap.org/consed/consed.html dgordon@uw.edu .

  15. Misunderstanding publication bias: editors are not blameless after all.

    PubMed

    Senn, Stephen

    2012-01-01

    In analysing whether there is an editorial bias in favour of positive studies, researchers have made implicit assumptions that are implausible. In particular, to justify the conclusion that there is no bias because observed editorial acceptance rates do not favour positive studies, the assumption that the decision to submit an article is based solely on quality would be required. If, on the other hand, submission were based on perceived probability of acceptance, negative and positive studies would not differ in terms of acceptance rates, but in terms of quality. It is shown, using a simple graphical model, how similar underlying situations as regards the relationship between quality and probability of acceptance on the one hand and study outcome (positive or negative) and probability of acceptance on the other could produce dramatically different results depending on the behaviour of authors. Furthermore, there is, in fact, some evidence that submitted negative studies are, on average, of higher quality than positive ones. This calls into question the standard interpretation of the studies examining editorial bias. It would appear that despite similar probabilities of acceptance for negative and positive studies, editors could be discriminating against negative studies.

  16. Geoyasgui: the Geosparql Query Editor and Result Set Visualizer

    NASA Astrophysics Data System (ADS)

    Beek, W.; Folmer, E.; Rietveld, L.; Walker, J.

    2017-07-01

    The Netherlands' Cadastre, Land Registry and Mapping Agency - in short Kadaster - collects and registers administrative and spatial data on property and the rights involved. This includes for ships, aircraft and telecommunications networks. Doing so, Kadaster protects legal certainty. The Kadaster publishes many large authoritative datasets including several key registers of the Dutch Government (Topography, Addresses and Buildings). Furthermore Kadaster is also developing and maintaining the PDOK shared service, in which about 100 spatial datasets are being published in several formats, including an incredible amount of detailed geospatial objects. Geospatial objects include all plots of land, all buildings, all roads and all lampposts. These objects are spatially and/or conceptually related, but are maintained by different data curators. As a result these datasets are syntactically and architecturally disjoint, and using them together currently requires non-trivial human labor. In response to this, Kadaster is currently publishing its geo-spatial data assets as Linked Open Data. The standardized query language for Linked Open Geodata is GeoSPARQL. Unfortunately, current tooling does not support writing and evaluating GeoSPARQL queries. This paper presents GeoYASGUI, a GeoSPARQL editor and result-set viewer with IDE capabilities. GeoYASGUI is not a new software product, but an integration of and a collection of updates to existing Open Source libraries. With GeoYASGUI it becomes possible to query the rich Open Data assets of the Kadaster.

  17. Training the unseasoned technical writer-editor: From the trainee's perspective

    SciTech Connect

    Gibbs, B.R.

    1991-01-01

    Many unseasoned technical writer-editors who are not adequately trained may become seasoned inadequately trained technical writer-editors. This problem can occur when a trainee is involved in an ineffective training program, but it can be alleviated by the trainer's assessing the unseasoned writer's talents, becoming involved with the trainee's growth in writing and editing skills, and helping him to visualize his potential as a technical writer-editor. Assessment, support, mentoring, and nurturing are important elements in the trainee's growth process and in any good training or internship program. 1 ref.

  18. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors´ Network

    PubMed Central

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J.; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J. J.; Varga, Albert; Lüscher, Thomas F.

    2017-01-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors´ Network of the European Society of Cardiology. PMID:28591318

  19. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors´ Network.

    PubMed

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    2017-05-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors´ Network of the European Society of Cardiology. Resumo O Comitê Internacional de Editores de Revistas Médicas (ICMJE) fornece recomendações para aprimorar o padrão editorial e a qualidade científica das revistas biomédicas. Tais recomendações variam desde requisitos técnicos de uniformização até assuntos editoriais mais complexos e elusivos, como os aspectos éticos do processo científico. Recentemente, foram propostos registro de ensaios clínicos, divulgação de conflitos de interesse e novos critérios de autoria, enfatizando a importância da responsabilidade e da responsabilização. No último ano, lançou-se uma nova iniciativa editorial para fomentar o compartilhamento dos dados de ensaios clínicos. Esta revisão discute essa nova iniciativa visando a aumentar a conscientização de leitores, investigadores, autores e editores filiados à Rede de Editores da Sociedade Europeia de Cardiologia.

  20. EDITORIAL: Farewell from the outgoing Editor-in-Chief Farewell from the outgoing Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Molenkamp, Laurens W.

    2011-12-01

    At the end of 2011 I will retire as Editor-in-Chief of Semiconductor Science and Technology, and I am very pleased to announce that the job will be taken over by Professor Kornelius Nielsch. In the ten years I have held this position, I have seen many new topics entering the journal: spintronics, organic semiconductors, and Dirac fermion physics, to name just a few. The journal has also witnessed a strong internationalization of the authorship, with an especially strong increase in contributions from the Far East—a growth that is likely to continue in the coming years. I am certain that Kornelius will do an excellent job in guiding the journal through the developments of the coming decade. I would like to thank the publishing team of SST, or rather the three consecutive teams I witnessed during my tenure at the journal, for the help and support they have given me. The people at IOP Publishing are doing a great job in running the journal, and have made it possible to considerably reduce the time to publication for our submissions. I much enjoyed the collaboration with the other members of the Editorial Board; our annual meetings have always been a source of inspiration. Last, but certainly not least, I would like to thank you, the scientific community, authors, referees and readers, for your continuing support of the journal.

  1. Issues in Communication Education: An Interview with Joe Ayers (Editor 1999-2002).

    ERIC Educational Resources Information Center

    Crandall, Heather; Hazel, Michael

    2002-01-01

    Presents an interview with Joe Ayres, editor of this journal from 1999 to 2002. Addresses issues such as curriculum content, competencies for undergraduate students, graduate students, student retention, and the role of mentoring in higher education. (SG)

  2. Writing Science Effectively: Biology and English Students in an Author-Editor Relationship.

    ERIC Educational Resources Information Center

    Kokkala, Irene; Gessell, Donna A.

    2003-01-01

    Reports on the design of a collaborative learning community linking students in biology and English courses in author-editor relationships. Delineates the steps of the project and provides sample evaluations for both groups. (Contains 19 references.) (DDR)

  3. Issues in Communication Education: An Interview with Joe Ayers (Editor 1999-2002).

    ERIC Educational Resources Information Center

    Crandall, Heather; Hazel, Michael

    2002-01-01

    Presents an interview with Joe Ayres, editor of this journal from 1999 to 2002. Addresses issues such as curriculum content, competencies for undergraduate students, graduate students, student retention, and the role of mentoring in higher education. (SG)

  4. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform.

    PubMed

    Hanwell, Marcus D; Curtis, Donald E; Lonie, David C; Vandermeersch, Tim; Zurek, Eva; Hutchison, Geoffrey R

    2012-08-13

    The Avogadro project has developed an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. It offers flexible, high quality rendering, and a powerful plugin architecture. Typical uses include building molecular structures, formatting input files, and analyzing output of a wide variety of computational chemistry packages. By using the CML file format as its native document type, Avogadro seeks to enhance the semantic accessibility of chemical data types. The work presented here details the Avogadro library, which is a framework providing a code library and application programming interface (API) with three-dimensional visualization capabilities; and has direct applications to research and education in the fields of chemistry, physics, materials science, and biology. The Avogadro application provides a rich graphical interface using dynamically loaded plugins through the library itself. The application and library can each be extended by implementing a plugin module in C++ or Python to explore different visualization techniques, build/manipulate molecular structures, and interact with other programs. We describe some example extensions, one which uses a genetic algorithm to find stable crystal structures, and one which interfaces with the PackMol program to create packed, solvated structures for molecular dynamics simulations. The 1.0 release series of Avogadro is the main focus of the results discussed here. Avogadro offers a semantic chemical builder and platform for visualization and analysis. For users, it offers an easy-to-use builder, integrated support for downloading from common databases such as PubChem and the Protein Data Bank, extracting chemical data from a wide variety of formats, including computational chemistry output, and native, semantic support for the CML file format. For developers, it can be easily extended via a powerful

  5. Polymeric lithography editor: Editing lithographic errors with nanoporous polymeric probes.

    PubMed

    Rajasekaran, Pradeep Ramiah; Zhou, Chuanhong; Dasari, Mallika; Voss, Kay-Obbe; Trautmann, Christina; Kohli, Punit

    2017-06-01

    A new lithographic editing system with an ability to erase and rectify errors in microscale with real-time optical feedback is demonstrated. The erasing probe is a conically shaped hydrogel (tip size, ca. 500 nm) template-synthesized from track-etched conical glass wafers. The "nanosponge" hydrogel probe "erases" patterns by hydrating and absorbing molecules into a porous hydrogel matrix via diffusion analogous to a wet sponge. The presence of an interfacial liquid water layer between the hydrogel tip and the substrate during erasing enables frictionless, uninterrupted translation of the eraser on the substrate. The erasing capacity of the hydrogel is extremely high because of the large free volume of the hydrogel matrix. The fast frictionless translocation and interfacial hydration resulted in an extremely high erasing rate (~785 μm(2)/s), which is two to three orders of magnitude higher in comparison with the atomic force microscopy-based erasing (~0.1 μm(2)/s) experiments. The high precision and accuracy of the polymeric lithography editor (PLE) system stemmed from coupling piezoelectric actuators to an inverted optical microscope. Subsequently after erasing the patterns using agarose erasers, a polydimethylsiloxane probe fabricated from the same conical track-etched template was used to precisely redeposit molecules of interest at the erased spots. PLE also provides a continuous optical feedback throughout the entire molecular editing process-writing, erasing, and rewriting. To demonstrate its potential in device fabrication, we used PLE to electrochemically erase metallic copper thin film, forming an interdigitated array of microelectrodes for the fabrication of a functional microphotodetector device. High-throughput dot and line erasing, writing with the conical "wet nanosponge," and continuous optical feedback make PLE complementary to the existing catalog of nanolithographic/microlithographic and three-dimensional printing techniques. This new PLE

  6. Special Article: Ronald D. Miller: tribute to a past editor-in-chief.

    PubMed

    Tuman, Kenneth J

    2012-12-01

    For anesthesiologists around the world who have practiced or trained in the past 4 decades, the name Ronald Miller, MD, has been synonymous with a commitment to excellence that has been evident in all aspects of his remarkable career as a distinguished clinician-scientist, editor, writer, and educator. Dr. Miller's contributions as Editor-in-Chief of Anesthesia & Analgesia (1991-2006) have stimulated this salutation of his career and of his influence on transforming the Journal.

  7. Exploring why and how journal editors retract articles: findings from a qualitative study.

    PubMed

    Williams, Peter; Wager, Elizabeth

    2013-03-01

    Editors have a responsibility to retract seriously flawed articles from their journals. However, there appears to be little consistency in journals' policies or procedures for this. In a qualitative study, we therefore interviewed editors of science journals using semi-structured interviews to investigate their experience of retracting articles. We identified potential barriers to retraction, difficulties in the process and also sources of support and encouragement. Our findings have been used as the basis for guidelines developed by the Committee on Publication Ethics.

  8. Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.

    PubMed Central

    1994-01-01

    In the 13 years since it was first published the "Uniform requirements for manuscripts submitted to biomedical journals" (the Vancouver style), developed by the International Committee of Medical Journal Editors, has been widely accepted by both authors and editors; over 400 journals have stated that they will consider manuscripts that conform to its requirements. This is the fourth edition of the "Uniform requirements." PMID:8287338

  9. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Gardner, Jason S.

    2012-01-01

    As I begin my tenure as Editor-in-Chief of Journal of Physics: Condensed Matter (JPCM), I look upon this opportunity as both an honour and a real challenge. The journal is in great shape thanks to the work of my predecessors, Marshall Stoneham and David Ferry. The journal's solid reputation is based largely on the work these gentlemen have done over the past decade. The other main reason for the success of JPCM is the amazing staff in Bristol; keep up the good work, please. When discussing the journal with scientists from all corners of the globe, one thing is always mentioned—JPCM is a very reliable journal with well-written, high-quality papers, and a fast but rigorous peer-review process that provides fair, detailed and constructive referee reports for the benefit of authors. This is due almost entirely to our great authors and referees; we rely on them every day—thank you. As the new Editor-in-Chief I hope to continue to improve still further the journal's status in condensed matter science. As mentioned above, our reputation is excellent, but the reality is that we live in a world of bibliometrics and rankings. Over the past few years JPCM has been repositioned as a journal at the forefront of condensed matter physics, and the impact of the journal should increase further as a result of continued emphasis on commissioning in cutting-edge areas identified by the Editorial Board and the journal team. In addition to regular papers, JPCM has a number of other content streams that authors and readers can benefit from. Fast track communications (FTCs) offer exceptionally fast publication for work of the highest impact and urgency. By their select nature, FTCs benefit from personal treatment by the Editorial Board and the average receipt-to-first-decision time is just 11 days (the average receipt-to-publication time is just 45 days). Topical reviews in JPCM make the journal one of the most authoritative sources of review content for condensed matter physics

  10. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Corkum, Paul

    2011-01-01

    As a journal that reports advances in atomic, molecular and optical science (AMO), Journal of Physics B: Atomic, Molecular and Optical Physics (J. Phys. B) provides the AMO research community with three unique fora: topical reviews, tutorials and special issues. Developed under the leadership of editor Jan Michael Rost and his Editorial Board, these sections have cemented J. Phys. B's reputation as a major journal showcasing the AMO community's advances. For me, an AMO scientist, it is therefore a special pleasure to be entrusted with continuing the tradition of excellence established by Jan Michael and the Editorial Board. I intend to build on this foundation by ensuring that the journal makes full use of these tools. Topical reviews: a unique focus When J. Phys. B becomes the first journal you turn to for initial reviews about important emerging areas in your field, we as an Editorial Board will have succeeded. To us, a topical review is different from a traditional review—a topical review focuses on emerging sub-fields of AMO physics. Its function is to alert and educate our readers about emerging opportunities. Topical reviews can also serve a closely related function for readers: keeping us up-to-date with critical technologies that lie slightly outside our own fields, such as advances in free-electron lasers science, (which will surely affect our field). Our overall goal is to make your research more productive because of the topical reviews you read within the journal. Tutorials J. Phys. B tutorials are aimed at graduate students or researchers venturing into a new field. Just as in my own research group I encourage all graduate students to write their theses in a way that will be useful to both future graduate students and the larger community beyond my group, J. Phys. B has designed tutorials to fill this function on the journal scale. Thus, tutorial authors are able to write in greater depth than can be included in a paper in nature, science or in the

  11. A scoping review of competencies for scientific editors of biomedical journals.

    PubMed

    Galipeau, James; Barbour, Virginia; Baskin, Patricia; Bell-Syer, Sally; Cobey, Kelly; Cumpston, Miranda; Deeks, Jon; Garner, Paul; MacLehose, Harriet; Shamseer, Larissa; Straus, Sharon; Tugwell, Peter; Wager, Elizabeth; Winker, Margaret; Moher, David

    2016-02-02

    Biomedical journals are the main route for disseminating the results of health-related research. Despite this, their editors operate largely without formal training or certification. To our knowledge, no body of literature systematically identifying core competencies for scientific editors of biomedical journals exists. Therefore, we aimed to conduct a scoping review to determine what is known on the competency requirements for scientific editors of biomedical journals. We searched the MEDLINE®, Cochrane Library, Embase®, CINAHL, PsycINFO, and ERIC databases (from inception to November 2014) and conducted a grey literature search for research and non-research articles with competency-related statements (i.e. competencies, knowledge, skills, behaviors, and tasks) pertaining to the role of scientific editors of peer-reviewed health-related journals. We also conducted an environmental scan, searched the results of a previous environmental scan, and searched the websites of existing networks, major biomedical journal publishers, and organizations that offer resources for editors. A total of 225 full-text publications were included, 25 of which were research articles. We extracted a total of 1,566 statements possibly related to core competencies for scientific editors of biomedical journals from these publications. We then collated overlapping or duplicate statements which produced a list of 203 unique statements. Finally, we grouped these statements into seven emergent themes: (1) dealing with authors, (2) dealing with peer reviewers, (3) journal publishing, (4) journal promotion, (5) editing, (6) ethics and integrity, and (7) qualities and characteristics of editors. To our knowledge, this scoping review is the first attempt to systematically identify possible competencies of editors. Limitations are that (1) we may not have captured all aspects of a biomedical editor's work in our searches, (2) removing redundant and overlapping items may have led to the

  12. EDITORIAL: Thank you and farewell from the Founding Editor

    NASA Astrophysics Data System (ADS)

    Baskes, Mike

    2005-07-01

    I have been involved with Modelling and Simulation in Materials Science and Engineering (MSMSE) from the very beginning when it was merely an idea, over 14 years ago, to the current journal that is well supported by the community. During my time as Editor there have been many changes in the journal, including the introduction of electronic submissions, web-based services and free printed colour where it is essential to the article, as well as completely free colour online. The journal has seen excellent growth in the number and quality of submissions and the number of articles published continues to rise, enabling us to expand the journal to eight issues in 2005. Web accesses and downloads have greatly surpassed even my wildest dreams. In my opinion, the emergence of MSMSE as a top materials modelling journal has confirmed the vision of Institute of Physics Publishing (IOPP) and the Executive Board that this area of science and engineering was ripe for a specialized journal. I feel that, having seen the journal through the early years and watched it grow into a successful arena for multidisciplinary materials research, it is now an appropriate time for me to hand over the reins. The journal has a great foundation for future growth and development and is supported by an excellent Editorial Board, who have given me a great deal of help and advice over the years. I feel sure that they will continue to support the journal when Bill Curtin, Brown University, takes over on 1 July 2005. Bill has the diverse experience in modelling at the atomic, dislocation, and continuum levels to lead the journal to new heights. Finally I would like to thank all of the readers, authors and referees who have greatly contributed to MSMSE over the years. Thank you for your support and help, and I hope you will continue to support the journal. Last, but not least, I would like to thank the staff at IOPP. Without their expert assistance, the journal could not have been as successful as it is

  13. Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

    PubMed Central

    2012-01-01

    Background The Avogadro project has developed an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. It offers flexible, high quality rendering, and a powerful plugin architecture. Typical uses include building molecular structures, formatting input files, and analyzing output of a wide variety of computational chemistry packages. By using the CML file format as its native document type, Avogadro seeks to enhance the semantic accessibility of chemical data types. Results The work presented here details the Avogadro library, which is a framework providing a code library and application programming interface (API) with three-dimensional visualization capabilities; and has direct applications to research and education in the fields of chemistry, physics, materials science, and biology. The Avogadro application provides a rich graphical interface using dynamically loaded plugins through the library itself. The application and library can each be extended by implementing a plugin module in C++ or Python to explore different visualization techniques, build/manipulate molecular structures, and interact with other programs. We describe some example extensions, one which uses a genetic algorithm to find stable crystal structures, and one which interfaces with the PackMol program to create packed, solvated structures for molecular dynamics simulations. The 1.0 release series of Avogadro is the main focus of the results discussed here. Conclusions Avogadro offers a semantic chemical builder and platform for visualization and analysis. For users, it offers an easy-to-use builder, integrated support for downloading from common databases such as PubChem and the Protein Data Bank, extracting chemical data from a wide variety of formats, including computational chemistry output, and native, semantic support for the CML file format. For developers, it can be

  14. CHAIRMEN'S PREFACE AND EDITORS' NOTE: Unification of Fundamental Interactions

    NASA Astrophysics Data System (ADS)

    Brink, Lars; Nilsson, Jan S.; Salomonson, Per; Skagerstam, Bo-Sture

    1987-01-01

    Vainshtein. We had hoped that the Nobel Symposium should be a signal for improved relations between East and West, but in this respect we failed. The Symposium was held in the small town of Marstrand, a summer resort on an island outside Göteborg. The idea was to have it relatively close to home and to show the participants perhaps the best part of the local nature. Another motive was to keep the participants semi-isolated to provide ample time for discussions. With the somewhat heavy programme we found that even so, the days were not long enough. This Symposium was the second Nobel Symposium on elementary particle physics. The first one, also organized by our group, was held in 1968. We hope and believe that the next one need not be awaited another 18 years! The Symposium was made possible by a generous grant from the Nobel Foundation. An additional grant from the Royal Swedish Academy of Sciences was also essential. A grant from Nordita made it possible to invite some ten Nordic observers. We also gratefully acknowledge help with the organization of the Symposium from the city of Goteborg, the city of Kungälv, Volvo, Skandinaviska Enskilda banken, Ericsson AB and IBM Sweden. We thank all the participants for all their efforts, to come to our remote part of the world, to give excellent talks, to write up their talks astonishingly quickly and to share with us so much of their knowledge and expertise. Last but not least we are indebted to the members of the organizing committee, members of the group and the secretarial staff. Goteborg, August 1986 Editors' NoteIn these Proceedings the lectures are given in the order of their oral presentation at the Symposium. Regrettably, a few contributors could not participate (V. Gribov, A. Linde, V. Ogievetsky, M. Shifman and A. M. Polyakov). Their contributions have been placed close to the end of the Proceedings. As these authors did not have the opportunity of correcting the proofs, responsibility for printing errors must rest with

  15. G. K. Batchelor. Founding editor of the Journal of Fluid Mechanics

    NASA Astrophysics Data System (ADS)

    Crighton, D. G.

    1999-05-01

    Although developments in fluid mechanics continue at a heady pace, and are reported in JFM at about 800 pages per month, things in the editorial management of JFM change only slowly. There is a continuity among the JFM Editorial Team and among the policies they espouse and implement that appears to be appreciated by the fluid mechanics community. A major change has, however, occurred from January 1999, in that George Batchelor has, after 43 years as Editor, stepped down from the day-to-day handling of papers and from the formulation of policies and practices, and allowed himself to be named on our masthead as Founding Editor. I say ‘allowed’ because George's initial wish was not to be so named, feeling that this might be seen as an immodest and presumptuous title. But Founding Editor is exactly what George was and is. He launched JFM in May 1956, having persuaded Taylor & Francis to be the publisher and printer, and having enlisted the help of G. F. Carrier, W. C. Griffith and M. J. Lighthill as Associate Editors, and T. Brooke Benjamin and I. Proudman as Assistant Editors. Then, as now, all members of the JFM Editorial Team were to work autonomously in the handling of papers, with complete delegated authority and similar workloads, but all following similar procedures and with similar philosophies, and all under the watchful eye of G. K. B.

  16. [The relevance of the International Committee of Medical Journal Editors (ICMJE) for medical publishing and research].

    PubMed

    Reyes, Humberto B

    2014-01-01

    The International Committee of Medical Journal Editors is a leading independent institution providing guidance for the report of biomedical research and health related topics in medical journals. Established in 1978, it is currently constituted by editors of fourteen general medical journals from different countries, plus one representative for the US National Library of Medicine and one representative for the World Association of Biomedical Journal Editors. Since 1978 the Committee provides a document, originally named "Uniform Requirements…", "to help authors, editors, and others involved in peer review and biomedical publishing create and distribute accurate, clear, unbiased medical journal articles". This document has been updated several times and the last version was released in August 2013, now renamed "Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals", available in www.icmje.org and citable as "ICMJE Recommendations". A vast proportion of medical journals, worldwide, have adopted these recommendations as rules. The ICMJE discusses and provides guidance on several relevant aspects including criteria on authorship, peer review, scientific misconduct, conflicts of interest, clinical trials registration, good editorial practices, the relations between editors and journal owners, the protection of individuals subject to medical research, the solvency of electronic publications, among others. The 2013 ICMJE Annual Meeting took place in Santiago, Chile, in November 4 and 5. The photograph shows attendants to the final session.

  17. STK Integrated Message Production List Editor (SIMPLE) for CEO Operations

    NASA Technical Reports Server (NTRS)

    Trenchard, Mike; Heydorn, James

    2014-01-01

    Late in fiscal year 2011, the Crew Earth Observations (CEO) team was tasked to upgrade and replace its mission planning and mission operations software systems, which were developed in the Space Shuttle era of the 1980s and 1990s. The impetuses for this change were the planned transition of all workstations to the Windows 7 64-bit operating system and the desire for more efficient and effective use of Satellite Tool Kit (STK) software required for reliable International Space Station (ISS) Earth location tracking. An additional requirement of this new system was the use of the same SQL database of CEO science sites from the SMMS, which was also being developed. STK Integrated Message Production List Editor (SIMPLE) is the essential, all-in-one tool now used by CEO staff to perform daily ISS mission planning to meet its requirement to acquire astronaut photography of specific sites on Earth. The sites are part of a managed, long-term database that has been defined and developed for scientific, educational, and public interest. SIMPLE's end product is a set of basic time and location data computed for an operator-selected set of targets that the ISS crew will be asked to photograph (photography is typically planned 12 to 36 hours out). The CEO operator uses SIMPLE to (a) specify a payload operations planning period; (b) acquire and validate the best available ephemeris data (vectors) for the ISS during the planning period; (c) ingest and display mission-specific site information from the CEO database; (d) identify and display potential current dynamic event targets as map features; (e) compute and display time and location information for each target; (f) screen and select targets based on known crew availability constraints, obliquity constraints, and real-time evaluated constraints to target visibility due to illumination (sun elevation) and atmospheric conditions (weather); and finally (g) incorporate basic, computed time and location information for each selected

  18. Role of editors and journals in detecting and preventing scientific misconduct: strengths, weaknesses, opportunities, and threats.

    PubMed

    Marusic, Ana; Katavic, Vedran; Marusic, Matko

    2007-09-01

    Scientific journals have a central place in protecting research integrity because published articles are the most visible documentation of research. We used SWOT analysis to audit (S)trengths and (W)eaknesses as internal and (O)pportunities and (T)hreats as external factors affecting journals' responsibility in addressing research integrity issues. Strengths include editorial independence, authority and expertise, power to formulate editorial policies, and responsibility for the integrity of published records. Weaknesses stem from having no mandate for legal action, reluctance to get involved, and lack of training. Opportunities for editors are new technologies for detecting misconduct, policies by editorial organization or national institutions, and greater transparency of published research. Editors face threats from the lack of legal regulation and culture of research integrity in academic communities, lack of support from stakeholders in scientific publishing, and different pressures. Journal editors cannot be the policing force of the scientific community but they should actively ensure the integrity of the scientific record.

  19. Transferable Output ASCII Data (TOAD) editor version 1.0 user's guide

    NASA Technical Reports Server (NTRS)

    Bingel, Bradford D.; Shea, Anne L.; Hofler, Alicia S.

    1991-01-01

    The Transferable Output ASCII Data (TOAD) editor is an interactive software tool for manipulating the contents of TOAD files. The TOAD editor is specifically designed to work with tabular data. Selected subsets of data may be displayed to the user's screen, sorted, exchanged, duplicated, removed, replaced, inserted, or transferred to and from external files. It also offers a number of useful features including on-line help, macros, a command history, an 'undo' option, variables, and a full compliment of mathematical functions and conversion factors. Written in ANSI FORTRAN 77 and completely self-contained, the TOAD editor is very portable and has already been installed on SUN, SGI/IRIS, and CONVEX hosts.

  20. An interactive editor for definition of touch-sensitive zones for a graphic display

    NASA Technical Reports Server (NTRS)

    Monroe, Burt L., III; Jones, Denise R.

    1987-01-01

    In the continuing effort to develop more efficient man-machine communications methods, touch displays have shown potential as straightforward input systems. The development of software necessary to handle such systems, however, can become tedious. In order to reduce the need for redundant programming, a touch editor has been developed which allows a programmer to interactively define touch-sensitive areas for a graphic display. The information produced during the editing process is written to a data file, which can be accessed easily when needed by an application program. This paper outlines the structure, logic, and use of the editor, as well as the hardware with which it is presently compatible.

  1. A Java chemical structure editor supporting the Modular Chemical Descriptor Language (MCDL).

    PubMed

    Trepalin, Sergei V; Yarkov, Alexander V; Pletnev, Igor V; Gakh, Andrei A

    2006-03-29

    A compact Modular Chemical Descriptor Language (MCDL) chemical structure editor (Java applet) is described. The small size (approximately 200 KB) of the applet allows its use to display and edit chemical structures in various Internet applications. The editor supports the MCDL format, in which structures are presented in compact canonical form and is capable of restoring bond orders as well as of managing atom and bond drawing overlap. A small database of cage and large cyclic fragment is used for optimal representation of difficult-to-draw molecules. The improved algorithm of the structure diagram generation can be used for other chemical notations that lack atomic coordinates (SMILES, InChI).

  2. Conflicts of interest for medical publishers and editors: protecting the integrity of scientific scholarship.

    PubMed

    Desai, Sapan S; Shortell, Cynthia K

    2011-09-01

    Competition of interest may exist at all levels in the medical publication process. Ensuring the integrity of scientific scholarship involves protecting editorial independence, promoting the use of scientific arbitration boards, promoting transparency throughout all stages of publication, and protecting the relationship between the publisher and its editors through an effective legal framework. It is incumbent upon the publisher, editors, authors, and readers to ensure that the highest standards of scientific scholarship are upheld. Doing so will help reduce fraud and misrepresentation in medical research and increase the trustworthiness of landmark findings in science.

  3. Magazine or journal--what is the difference? The role of the monitoring editor.

    PubMed

    Bretscher, Anthony

    2013-04-01

    Scientific communication, career advancement, and funding decisions are all dependent on research publications. The way manuscripts are handled by high-visibility, professionally edited magazines differs from the way academic journals evaluate manuscripts, using active scientists as monitoring editors. In this essay, I discuss the benefits that come with the involvement of active scientists. I enumerate the decisions a monitoring editor has to make, and how he or she goes about making them. Finally, I indicate ways in which authors can help to make the process a smoother and more positive experience.

  4. Professional Wisdom and Writing for Publication: Qualitative Interviews with Editors and Authors in Early Childhood Education

    ERIC Educational Resources Information Center

    Jalongo, Mary Renck

    2013-01-01

    College and university faculty members specializing in early childhood education face some unique challenges in scholarly writing. The purpose of this research was to use open-ended interviews as a way to gather the collective wisdom of a group of key informants about academic writing and publishing in the field. Twenty-two editors and/or authors,…

  5. Advancing the Profession through Journals: The Editor-Author-Profession Partnership [in HRD].

    ERIC Educational Resources Information Center

    1995

    These three papers are from a symposium on professional journals that was facilitated by Wim J. Nijhoff at the 1995 Academy of Human Resource Development (HRD) conference. "Advancing the Profession through Journals: The Editor-Author-Profession Partnership" (Gary N. McLean) describes the purpose and operation of the "Human Resource…

  6. Learning the Attachment Theory with the CM-ED Concept Map Editor

    ERIC Educational Resources Information Center

    Rueda, U.; Arruarte, A.; Elorriaga, J. A.; Herran, E.

    2009-01-01

    This paper presents a study carried out at the University of the Basque Country UPV/EHU with the aim of evaluating the CM-ED (concept map editor) with social education students. Concept mapping is a widely accepted technique that promotes meaningful learning. Graphically representing concepts of the learning domain and relationships between them…

  7. Advancing the Profession through Journals: The Editor-Author-Profession Partnership [in HRD].

    ERIC Educational Resources Information Center

    1995

    These three papers are from a symposium on professional journals that was facilitated by Wim J. Nijhoff at the 1995 Academy of Human Resource Development (HRD) conference. "Advancing the Profession through Journals: The Editor-Author-Profession Partnership" (Gary N. McLean) describes the purpose and operation of the "Human Resource…

  8. The Newspaper Editor As Graphic Strategist. ANPA News Research Report No. 27.

    ERIC Educational Resources Information Center

    Garcia, Mario R.

    This report discusses the graphic strategies available to editors for positioning the day's news. The purposes of the report are: (1) to introduce those in charge of designing the newspaper page to the structural approach to design (the structural approach is defined as incorporating horizontal and vertical structures in the available spaces,…

  9. Improving the Yield of Rural Education Research: An Editor's Swan Song

    ERIC Educational Resources Information Center

    Coladarci, Theodore

    2007-01-01

    In my 15th and final year as JRRE editor, I identify methodological and substantive shortcomings in the rural education research literature and, in turn, suggest strategies for improvement. I structure my observations around the following considerations: describing the rural context of research, making the rural argument, framing the research…

  10. University-government relationships in the training of technical writers-editors

    NASA Technical Reports Server (NTRS)

    Stohrer, Freda F.; Pinelli, Thomas E.

    1979-01-01

    Traditional and nontraditional methods of training technical writers-editors are reviewed. Combining work experience with classroom instruction in the form of cooperative education provides a method of strengthening the Federal career service in professional occupations. The NASA Langley experience that successfully introduced students to the special demands of technical writing and editing is described.

  11. Parting messages from current and former editors of the Journal of Andrology.

    PubMed

    Bartke, Andrzej; Orgebin-Crist, Marie-Claire; Desjardins, Claude; Lewis, Ron; Tindall, Don; Hamilton, David W; Pryor, Jon L; Schlegel, Peter N; Hardy, Matthew P; Burnett, Arthur L Bud; Darney, Sally P; Sandlow, Jay

    2012-01-01

    The proposal to produce this final commemorative issue for the Journal of Andrology arose during our regular discussions as current editors soon after it was announced that the Journal would complete its own life course and merge into a new publication (to be named Andrology) with the International Journal of Andrology. We considered the momentous occasion to be one that should be celebrated with an enduring tribute in recognition of the Journal's exceptional 33-year existence. Among the various contributions sought for inclusion in this issue, we envisioned an article assembling collected short essays from all living former editors drawing on notable events and highlights, if not less well-known challenges and successes arising during their editorship eras. We thought that any such production of musings, viewpoints, and most of all words of wisdom from those who have had major roles in the direction and accomplishments of the Journal would offer an illuminating read for the society's members and friends and provide all readers another venue to share in and enjoy the Journal's great history. We are enthralled to have gathered these collections, all personal compositions of the former editors-in-chief, and for their effort that has helped us complete this special endeavor we express to them our tremendous gratitude. Serving as the Journal's last editors, we are also grateful to contribute our essay at the very end as part of this joyous chronicle.

  12. The Open Forum: A Study of Letters to the Editor and the People Who Write Them.

    ERIC Educational Resources Information Center

    Pasternack, Steve

    More letters to the editor are being written to daily newspapers than ever before, and more of them are being published in ever-expanding letters columns. However, many letters go unpublished because of the letter's unsuitability, lack of space, or the writer's view having already been expressed. A study examined--by combining the methods of…

  13. The Newspaper Editor As Graphic Strategist. ANPA News Research Report No. 27.

    ERIC Educational Resources Information Center

    Garcia, Mario R.

    This report discusses the graphic strategies available to editors for positioning the day's news. The purposes of the report are: (1) to introduce those in charge of designing the newspaper page to the structural approach to design (the structural approach is defined as incorporating horizontal and vertical structures in the available spaces,…

  14. FlaME: Flash Molecular Editor - a 2D structure input tool for the web.

    PubMed

    Dallakian, Pavel; Haider, Norbert

    2011-02-01

    So far, there have been no Flash-based web tools available for chemical structure input. The authors herein present a feasibility study, aiming at the development of a compact and easy-to-use 2D structure editor, using Adobe's Flash technology and its programming language, ActionScript. As a reference model application from the Java world, we selected the Java Molecular Editor (JME). In this feasibility study, we made an attempt to realize a subset of JME's functionality in the Flash Molecular Editor (FlaME) utility. These basic capabilities are: structure input, editing and depiction of single molecules, data import and export in molfile format. The result of molecular diagram sketching in FlaME is accessible in V2000 molfile format. By integrating the molecular editor into a web page, its communication with the HTML elements on this page is established using the two JavaScript functions, getMol() and setMol(). In addition, structures can be copied to the system clipboard. A first attempt was made to create a compact single-file application for 2D molecular structure input/editing on the web, based on Flash technology. With the application examples presented in this article, it could be demonstrated that the Flash methods are principally well-suited to provide the requisite communication between the Flash object (application) and the HTML elements on a web page, using JavaScript functions.

  15. How Well Do Americans Know Geography? "National Geographic" Editor Discusses Meaning for Schools (Interview).

    ERIC Educational Resources Information Center

    Koerner, Thomas

    1987-01-01

    Gilbert Grosvenor, editor of "National Geographic," is interviewed about the importance of geography for Americans. He claims our lack of geographic knowledge impedes our ability to act and compete in the world market as a world power and points out that geographic ignorance extends to people employed at high levels of government. (MD)

  16. Book Selection Criteria of Children's Book Editors and Elementary Classroom Teachers.

    ERIC Educational Resources Information Center

    McKeon, Helen M.

    This paper describes a study of the criteria children's book editors and elementary classroom teachers use to select fiction books for children in grades four, five, and six. A questionnaire was sent to all members of the Children's Book Council and to elementary classroom teachers of grades four, five, and six in each elementary school in…

  17. Guidelines for Reviewers and the Editor at the Nuclear Safety Information Center.

    ERIC Educational Resources Information Center

    Whetsel, H. B.

    The main purpose of this report is to help novice reviewers accelerate their apprenticeship at the Nuclear Safety Information Center, a computerized information service sponsored by the U.S. Atomic Energy Commission. Guidelines for reviewers are presented in Part 1; Part 2 contains guidelines for the novice editor. The goal of the reviewers and…

  18. FlaME: Flash Molecular Editor - a 2D structure input tool for the web

    PubMed Central

    2011-01-01

    Background So far, there have been no Flash-based web tools available for chemical structure input. The authors herein present a feasibility study, aiming at the development of a compact and easy-to-use 2D structure editor, using Adobe's Flash technology and its programming language, ActionScript. As a reference model application from the Java world, we selected the Java Molecular Editor (JME). In this feasibility study, we made an attempt to realize a subset of JME's functionality in the Flash Molecular Editor (FlaME) utility. These basic capabilities are: structure input, editing and depiction of single molecules, data import and export in molfile format. Implementation The result of molecular diagram sketching in FlaME is accessible in V2000 molfile format. By integrating the molecular editor into a web page, its communication with the HTML elements on this page is established using the two JavaScript functions, getMol() and setMol(). In addition, structures can be copied to the system clipboard. Conclusion A first attempt was made to create a compact single-file application for 2D molecular structure input/editing on the web, based on Flash technology. With the application examples presented in this article, it could be demonstrated that the Flash methods are principally well-suited to provide the requisite communication between the Flash object (application) and the HTML elements on a web page, using JavaScript functions. PMID:21284863

  19. Light chain editors of anti-DNA receptors in human B cells.

    PubMed

    Kalinina, Olga; Wang, Yue; Sia, Kevin; Radic, Marko; Cazenave, Pierre-André; Weigert, Martin

    2014-02-10

    Receptor editing is a mechanism of self-tolerance used in newly generated B cells. The expressed heavy (H) or light (L) chain of an autoreactive receptor is replaced by upstream V genes which eliminate or modify autoreactivity. Editing of anti-DNA receptors has been characterized in anti-DNA transgenic mouse models including 3H9, 3H9/56R, and their revertant 3H9GL. Certain L chains, termed editors, rescue anti-DNA B cells by neutralizing or modifying DNA binding of the H chain. This editing mechanism acts on the natural H chain repertoire; endogenous H chains with anti-DNA features are expressed primarily in combination with editor L chains. We ask whether a similar set of L chains exists in the human repertoire, and if so, do they edit H chains with anti-DNA signatures? We compared the protein sequences of mouse editors to all human L chains and found several human L chains similar to mouse editors. These L chains diminish or veto anti-DNA binding when expressed with anti-DNA H chains. The human H chains expressed with these L chains also have relatively high arginine (Arg) content in the H chain complementarity determining region (H3), suggesting that receptor editing plays a role in establishing tolerance to DNA in humans.

  20. Light chain editors of anti-DNA receptors in human B cells

    PubMed Central

    Kalinina, Olga; Wang, Yue; Sia, Kevin; Radic, Marko; Cazenave, Pierre-André

    2014-01-01

    Receptor editing is a mechanism of self-tolerance used in newly generated B cells. The expressed heavy (H) or light (L) chain of an autoreactive receptor is replaced by upstream V genes which eliminate or modify autoreactivity. Editing of anti-DNA receptors has been characterized in anti-DNA transgenic mouse models including 3H9, 3H9/56R, and their revertant 3H9GL. Certain L chains, termed editors, rescue anti-DNA B cells by neutralizing or modifying DNA binding of the H chain. This editing mechanism acts on the natural H chain repertoire; endogenous H chains with anti-DNA features are expressed primarily in combination with editor L chains. We ask whether a similar set of L chains exists in the human repertoire, and if so, do they edit H chains with anti-DNA signatures? We compared the protein sequences of mouse editors to all human L chains and found several human L chains similar to mouse editors. These L chains diminish or veto anti-DNA binding when expressed with anti-DNA H chains. The human H chains expressed with these L chains also have relatively high arginine (Arg) content in the H chain complementarity determining region (H3), suggesting that receptor editing plays a role in establishing tolerance to DNA in humans. PMID:24470445

  1. Editorial: Conflict of interest policy for Editors of The American Journal of Clinical Nutrition

    USDA-ARS?s Scientific Manuscript database

    Integrity in the publication process requires impartiality at all levels of review. The American Journal of Clinical Nutrition (AJCN) adheres to the policy of the International Committee of Medical Journal Editors (ICMJE), Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writin...

  2. Professional Wisdom and Writing for Publication: Qualitative Interviews with Editors and Authors in Early Childhood Education

    ERIC Educational Resources Information Center

    Jalongo, Mary Renck

    2013-01-01

    College and university faculty members specializing in early childhood education face some unique challenges in scholarly writing. The purpose of this research was to use open-ended interviews as a way to gather the collective wisdom of a group of key informants about academic writing and publishing in the field. Twenty-two editors and/or authors,…

  3. The View from the Editor's Chair: Dewey Decimal Classification 16 to 19.

    ERIC Educational Resources Information Center

    Custer, Benjamin A.

    The retiring editor of Dewey Decimal Classification recounts the development of the system from the 16th through the 19th editions, i.e., 1956-1980. During this period, the system has undergone major changes to internationalize its character. Special provisions have been incorporated for branches of history, geography, language, literature, the…

  4. An International Call for Democratizing the Academic Journal Culture from a Community of Editors

    ERIC Educational Resources Information Center

    Mullen, Carol A.; Pryor, Caroline R.; Browne-Ferrigno, Tricia; Harris, Sandra L.

    2013-01-01

    In our reflective essay from our multiple perspectives as journal editors, peer reviewers, and published authors, we present ideas about editorial support, democracy, and innovation in the publishing process. As four tenured professors who work in universities in the states of Illinois, Virginia, Texas, and Kentucky, we are a community of editors…

  5. Improving the Yield of Rural Education Research: An Editor's Swan Song

    ERIC Educational Resources Information Center

    Coladarci, Theodore

    2007-01-01

    In my 15th and final year as JRRE editor, I identify methodological and substantive shortcomings in the rural education research literature and, in turn, suggest strategies for improvement. I structure my observations around the following considerations: describing the rural context of research, making the rural argument, framing the research…

  6. 29 CFR 793.11 - Combination announcer, news editor and chief engineer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... television stations. It is known at the time of such debate that these stations employ only a small number of employees and that, at times, an employee of such a station may perform a variety of duties in connection... editor and chief engineer. The 13(b)(9) exemption, as was made clear during the debate on the...

  7. Interview with the editor: David L. Turpin by Robert P. Scholz.

    PubMed

    Turpin, David L

    2010-04-01

    David L. Turpin has worked on dental journals for over 30 years--from his early days on the Pacific Coast Society of Orthodontists Bulletin, to the Angle Orthodontist, and to the American Journal of Orthodontics and Dentofacial Orthopedics. He will retire as editor-in-chief of the American Journal of Orthodontics and Dentofacial Orthopedics at the end of 2010.

  8. Persnickety editor, Founding Father, Mentor and Friend: The Legacy of Fred Mumpton

    NASA Technical Reports Server (NTRS)

    Ming, Douglas W.

    2006-01-01

    This paper is a tribute to Dr Fred Munpton, the founder of the International Committee on Natural Zeolites (ICNZ), by one of his students, who later succeed him as president of the ICNZ. The tribute reflects on Dr. Mumpton's skills as an editor and his zeal for the study of natural zeolites.

  9. The CZMIL manual editor (CME): a new tool for analyzing bathymetric lidar waveforms and editing point clouds

    NASA Astrophysics Data System (ADS)

    Morris, Gary Q.; Depner, Jan; Hilderbrand, Ronnie; Ramnath, Vinod

    2010-04-01

    The University of Southern Mississippi's Center of Higher Learning has developed a Waveform Viewer, Attribute Viewer, and a 3D Editor for use in the CZMIL Point Cloud Manual Editor (CME). The Waveform Viewer displays various channels of CZMIL waveforms within the 2D/3D editor interface of CME. This module provides the user an interactive tool set consisting of a cross sectioning mechanism for the intensity time-bin relationship, waveform file output, and zooming capabilities. The Attribute Viewer provides the data analyst with information to analyze various environmental and spatial parameters that might contribute to errors in the measured points. The 3D Editor offers the benefits of capturing depth outliers; an intuitive visual connectivity with the 2D editor; and the implementation of volumetric directional slice isolation of data outliers.

  10. Guidelines, editors, pharma and the biological paradigm shift.

    PubMed

    Singh, Ajai R; Singh, Shakuntala A

    2007-01-01

    relatively recent survey of 2002, it was found that about 60% of 192 authors of clinical practice guidelines reported they had financial connections with the companies whose drugs were under consideration. There is a strong case for making CPGs based not just on effectivity but cost effectivity. The various ramifications of this need to be spelt out. Work of bodies like the Appraisal of Guidelines Research and Evaluation (AGREE) Collaboration and Guidelines Advisory Committee (GAC) are also worth a close look.Even the actions of Foundations that work for disease amelioration have come under scrutiny. The process of setting up 'Best Practices' Guidelines for interactions between the pharmaceutical industry and clinicians has already begun and can have important consequences for patient care. Similarly, Good Publication Practice (GPP) for pharmaceutical companies have also been set up aimed at improving the behaviour of drug companies while reporting drug trialsThe rapidly increasing trend toward influence and control by industry has become a concern for many. It is of such importance that the Association of American Medical Colleges has issued two relatively new documents - one, in 2001, on how to deal with individual conflicts of interest; and the other, in 2002, on how to deal with institutional conflicts of interest in the conduct of clinical research. Academic Medical Centers (AMCs), as also medical education and research institutions at other places, have to adopt means that minimize their conflicts of interest.Both medical associations and research journal editors are getting concerned with individual and institutional conflicts of interest in the conduct of clinical research and documents are now available which address these issues. The 2001 ICMJE revision calls for full disclosure of the sponsor's role in research, as well as assurance that the investigators are independent of the sponsor, are fully accountable for the design and conduct of the trial, have

  11. Scientific value of systematic reviews: survey of editors of core clinical journals.

    PubMed

    Meerpohl, Joerg J; Herrle, Florian; Reinders, Stefan; Antes, Gerd; von Elm, Erik

    2012-01-01

    Synthesizing research evidence using systematic and rigorous methods has become a key feature of evidence-based medicine and knowledge translation. Systematic reviews (SRs) may or may not include a meta-analysis depending on the suitability of available data. They are often being criticised as 'secondary research' and denied the status of original research. Scientific journals play an important role in the publication process. How they appraise a given type of research influences the status of that research in the scientific community. We investigated the attitudes of editors of core clinical journals towards SRs and their value for publication. We identified the 118 journals labelled as "core clinical journals" by the National Library of Medicine, USA in April 2009. The journals' editors were surveyed by email in 2009 and asked whether they considered SRs as original research projects; whether they published SRs; and for which section of the journal they would consider a SR manuscript. The editors of 65 journals (55%) responded. Most respondents considered SRs to be original research (71%) and almost all journals (93%) published SRs. Several editors regarded the use of Cochrane methodology or a meta-analysis as quality criteria; for some respondents these criteria were premises for the consideration of SRs as original research. Journals placed SRs in various sections such as "Review" or "Feature article". Characterization of non-responding journals showed that about two thirds do publish systematic reviews. Currently, the editors of most core clinical journals consider SRs original research. Our findings are limited by a non-responder rate of 45%. Individual comments suggest that this is a grey area and attitudes differ widely. A debate about the definition of 'original research' in the context of SRs is warranted.

  12. Financial, nonfinancial and editors' conflicts of interest in high-impact biomedical journals.

    PubMed

    Bosch, Xavier; Pericas, Juan M; Hernández, Cristina; Doti, Pamela

    2013-07-01

    To assess financial, nonfinancial and editors' conflicts of interest (COI) disclosure policies among the most influential biomedical journals publishing original research. We conducted a cross-sectional study of 399 high-impact biomedical journals in 27 biomedical categories of the Journal Citation Reports (JCR) in December 2011. Information relevant to COI and requirements for disclosures that was publicly available on journal websites was collected. While financial COI disclosures were required by 358 (89.7%) and nonfinancial by 280 (70.2%) journals, 155 (38.8%) required editors' disclosures. Journals in the first decile of the JCR classification scored significantly higher than those in the second decile for all disclosure policies. Ninety (22.6%) journals were published by Elsevier and 59 (14.8%) by Wiley-Blackwell, with Elsevier scoring significantly better in financial disclosure policies (P = 0.022). Clinical journals scored significantly higher than basic journals for all disclosure policies. No differences were observed between open-access (n = 25) and nonopen-access (n = 374) journals for any type of disclosure. Somewhat incoherently, authors' disclosure statements were included in some published manuscript in 57.1% of journals without any COI disclosure policies. Authors' financial COI disclosures were required by about 90% of high-impact clinical and basic journals publishing original research. Unlike recent studies showing a significantly lower prevalence of nonfinancial compared with financial disclosures, the former were required by about 70% of journals, suggesting that editors are increasingly concerned about nonfinancial competing interests. Only 40% of journals required disclosure of editors' COI, in conflict with the recommendations of the most influential editors' associations. © 2013 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

  13. [Co-editors and editors with Jewish origins of the first German journals for anaesthesia. Their fate under National Socialism and an attempt at a biographical appreciation].

    PubMed

    Goerig, M; Goetz, A E

    2010-09-01

    The decision to publish the journals Der Schmerz and Narkose und Anaesthesie in 1928 was an important step towards the professionalization of anaesthesiology in Germany. The appearance of both journals, which for economic reasons merged into Schmerz - Narkose - Anaesthesie 1 year later, was initiated and vehemently supported by Jewish physicians. As editors and co-editors they were deeply involved with the editorial tasks of the journals for years from the early beginnings. When the National Socialistic Party took over the government in Germany many of the Jewish colleagues were forced to quit their editorial tasks, were eliminated and replaced by "Arians", they were persecuted and often arrested, forced to emigrate or decided to commit suicide due to inhumane personal circumstances. It is our intention to recall the biography and the terrible fate of the nearly unknown Jewish members of the editorial board of the first German anaesthesia journals. Moreover the biographic sketches promote a continuous discussion about the victims of an inhumane and barbarous ideology.

  14. Red`s natural editor: A program designed to edit FORTRAN programs

    SciTech Connect

    Cullen, D.E.

    1993-09-01

    This program allows the user to edit files using a completely natural method. You don`t need a lot of time to learn how to use this program; it`s as simple as using a typewriter. Even while you are reading this report you can start editing files. Although it is as simple as using a typewriter, this is a full screen editor, so that you can overwrite (replace) anything, delete or insert characters or lines, copy or move lines, find or change anything. All of this can be done without using any complicated combinations of key strokes (as you are forced to memorize with other editors). This program is written in standard FORTRAN. Although it was designed and implemented on an IBM-PC, it can be easily adapted for use on virtually any graphics terminal.

  15. Editor's perspective on the ECSS dedicated issue on green tides in the Yellow Sea

    NASA Astrophysics Data System (ADS)

    Valiela, Ivan

    2015-09-01

    Most of us learned about the extraordinary macroalgal bloom in the Yellow Sea through press reports previous to the 2008 Olympic competition in China. I was made aware of the extensive research efforts on this remarkable case of human-prompted, large-scale environmental change by discussions with Dr. Dongyan Liu during the 2012 ECSA conference in Venice. It soon became evident that it would be of great interest to the international audience to bring together results from the many different research projects on different aspects of this topic, taking place in different institutions and agencies. I therefore suggested that a committee of guest editors for the Issue be organized. The guest editors were charged with inviting the many researchers involved in work on the different aspects of the "green tide" phenomenon to contribute articles, request reviews of the submissions, and with helping me in editing the submissions.

  16. Programming the Navier-Stokes computer: An abstract machine model and a visual editor

    NASA Technical Reports Server (NTRS)

    Middleton, David; Crockett, Tom; Tomboulian, Sherry

    1988-01-01

    The Navier-Stokes computer is a parallel computer designed to solve Computational Fluid Dynamics problems. Each processor contains several floating point units which can be configured under program control to implement a vector pipeline with several inputs and outputs. Since the development of an effective compiler for this computer appears to be very difficult, machine level programming seems necessary and support tools for this process have been studied. These support tools are organized into a graphical program editor. A programming process is described by which appropriate computations may be efficiently implemented on the Navier-Stokes computer. The graphical editor would support this programming process, verifying various programmer choices for correctness and deducing values such as pipeline delays and network configurations. Step by step details are provided and demonstrated with two example programs.

  17. Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors.

    PubMed

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Blackmore, Heather; Kitas, George D

    2011-11-01

    Review articles comprehensively covering a specific topic are crucial for successful research and academic projects. Most editors consider review articles for special and regular issues of journals. Writing a review requires deep knowledge and understanding of a field. The aim of this review is to analyze the main steps in writing a narrative biomedical review and to consider points that may increase the chances of success. We performed a comprehensive search through MEDLINE, EMBASE, Scopus, and Web of Science using the following keywords: review of the literature, narrative review, title, abstract, authorship, ethics, peer review, research methods, medical writing, scientific writing, and writing standards. Opinions expressed in the review are also based on personal experience as authors, peer reviewers, and editors.

  18. Ensuring the Quality, Fairness, and Integrity of Journal Peer Review: A Possible Role of Editors.

    PubMed

    Resnik, David B; Elmore, Susan A

    2016-02-01

    A growing body of literature has identified potential problems that can compromise the quality, fairness, and integrity of journal peer review, including inadequate review, inconsistent reviewer reports, reviewer biases, and ethical transgressions by reviewers. We examine the evidence concerning these problems and discuss proposed reforms, including double-blind and open review. Regardless of the outcome of additional research or attempts at reforming the system, it is clear that editors are the linchpin of peer review, since they make decisions that have a significant impact on the process and its outcome. We consider some of the steps editors should take to promote quality, fairness and integrity in different stages of the peer review process and make some recommendations for editorial conduct and decision-making.

  19. Influencing health debates through letters to the editor: the case of male circumcision.

    PubMed

    Carpenter, Laura M

    2009-04-01

    In this article I use the case of male circumcision (MC) to examine how grassroots activists, medical professionals, other stakeholders, and ordinary people employ letters to the editor (LTEs) to influence public health debates. I also show how journalistic practices affect the use of LTEs. Seventy LTEs about MC from U.S. newspapers between 1985 and 2006 are analyzed using qualitative methods. Pro-MC, anti-MC, and neutral LTE writers supported their stances on similar grounds, described adversaries as biased, and stressed medical and scientific authority. Yet only MC advocates and neutralists trivialized MC and declined to justify their stances, suggesting distinctive dynamics for LTEs about widely accepted practices. The prevalence of debated practices and activists' efforts to piggyback on related issues also affect LTE content. Editors chose LTEs to address readers' critiques, enact news values like balance and controversy, and showcase writers with strong claims to legitimacy, thereby mediating public health debates.

  20. Are Women Underrepresented as Authors and Editors of Educational Psychology Journals?

    PubMed

    Robinson; McKay; Katayama; Fan

    1998-07-01

    To determine the progress women have made in the last 20 years in terms of contributions to the knowledge base (i.e., authorship) and reputations as leading contributors (i.e., appointments as editors and editorial board members) in educational psychology, we analyzed data from six journals: the American Educational Research Journal, Contemporary Educational Psychology, the Educational Psychologist, Educational Psychology Review, the Journal of Experimental Education, and the Journal of Educational Psychology. Results indicated that (a) women's progress in terms of authorships could be predicted by their increasing representation as educational psychologists, (b) opportunities for females to become editorial board members seem to be getting better, and (c) opportunities for females to become editors seem to be getting worse. Copyright 1998 Academic Press.

  1. A Development Method for Multiagent Simulators Using a Graphical Model Editor

    NASA Astrophysics Data System (ADS)

    Murakami, Masatoshi; Maruo, Tomoaki; Matsumoto, Keinosuke; Mori, Naoki

    A multiagent simulator (MAS) attracts attention as an approach to analyze social phenomena and complex systems in recent years. In addition, many frameworks for developing MAS are also proposed. These frameworks make the amount of development work reduce. But it is necessary to build models that are required to develop simulators from scratch. It becomes a burden to developers. These models would be specialized in the frameworks and lack in reusability. To solve these problems, this paper proposes a graphical model editor that can diagrammatically build models and a simulator development method using the editor. Saving models in a general-purpose form, these models are applicable to various frameworks. Numerical experiments show that the proposed method is effective in MAS development.

  2. PriorsEditor: a tool for the creation and use of positional priors in motif discovery

    PubMed Central

    Klepper, Kjetil; Drabløs, Finn

    2010-01-01

    Summary: Computational methods designed to discover transcription factor binding sites in DNA sequences often have a tendency to make a lot of false predictions. One way to improve accuracy in motif discovery is to rely on positional priors to focus the search to parts of a sequence that are considered more likely to contain functional binding sites. We present here a program called PriorsEditor that can be used to create such positional priors tracks based on a combination of several features, including phylogenetic conservation, nucleosome occupancy, histone modifications, physical properties of the DNA helix and many more. Availability: PriorsEditor is available as a web start application and downloadable archive from http://tare.medisin.ntnu.no/priorseditor (requires Java 1.6). The web site also provides tutorials, screenshots and example protocol scripts. Contact: kjetil.klepper@ntnu.no PMID:20628076

  3. How the public responded to the Schiavo controversy: evidence from letters to editors.

    PubMed

    Racine, Eric; Karczewska, Marta; Seidler, Matthew; Amaram, Rakesh; Illes, Judy

    2010-09-01

    The history and genesis of major public clinical ethics controversies is intimately related to the publication of opinions and responses in media coverage. To provide a sample of public response in the media, this paper reports the results of a content analysis of letters to editors published in the four most prolific American newspapers for the Schiavo controversy. Opinions expressed in the letters sampled strongly supported the use of living wills and strongly condemned public attention to the case as well as political interventions. Letters tended to be against withdrawal of life support, proxy consent and associated procedures as well as against court decisions and legal procedures. In comparison with reports written by journalists, letters to editors contained fewer controversial claims about Schiavo''s neurological condition and behavioural repertoire but similar loaded language to describe withdrawal of life support. Distinct public discourses can be encountered in different stakeholders suggesting complex and extensive pluralism even within the media.

  4. On being the Editor of the Medical Journal of Australia: Living dangerously.

    PubMed

    Van Der Weyden, Martin B

    2012-01-01

    Editorial independence is crucial for the viability of a journal and editors have many masters - the public, the readers, the authors and the owners. Negotiating the resultant minefield requires a purposeful and independent stance. This is particularly so in instances of a relatively modern phenomenon: concerted attempts by clinical groups to influence, or even abort, publication of articles, which may threaten their practice. Moreover, modern social media facilitates this manipulation.

  5. On being the Editor of the Medical Journal of Australia: Living dangerously

    PubMed Central

    Van Der Weyden, Martin B.

    2012-01-01

    Editorial independence is crucial for the viability of a journal and editors have many masters – the public, the readers, the authors and the owners. Negotiating the resultant minefield requires a purposeful and independent stance. This is particularly so in instances of a relatively modern phenomenon: concerted attempts by clinical groups to influence, or even abort, publication of articles, which may threaten their practice. Moreover, modern social media facilitates this manipulation. PMID:22654390

  6. [Hendrik Burger, editor-in-chief of the Dutch Journal of Medicine 1904- 1913].

    PubMed

    van't Hof, S E

    2007-07-28

    Hendrik Burger (1864-1957) became the sixth editor-in-chief of the Journal before gaining international fame as a professor of otorhinolaryngology. He was more a teacher than researcher, and his clinic in Amsterdam became an internationally renowned training centre. He advocated better public healthcare for children who were deaf/mute or had impaired hearing and founded schools for these children. A prolific writer, Burger contributed more than 400 papers to the Journal.

  7. Improving rural newspaper coverage of nutrition stories: an educational assessment of editors' attitudes and learning needs.

    PubMed

    Nothwehr, Faryle; Chrisman, Matthew; Andsager, Julie L

    2014-11-01

    Local newspapers are an important source of information for rural residents but often lack accurate or helpful nutrition-related information. To improve the quantity and quality of nutrition stories in rural, local newspapers, it is important to understand the perspective of editors. An online survey of 51 rural Midwest editors was conducted to assess attitudes toward writing nutrition stories, sources of information, perceived challenges, and interest in learning more about writing such stories. Of respondents, 49% were female, and 63% had at least a 4-year college degree. Through a mix of closed- and open-ended questions, the majority indicated positive attitudes toward nutrition stories, were confident in their abilities to write them, and expressed interest in learning more. Challenges cited include lack of print space, small staff, lack of specific requests from readers for nutrition stories, and the need to avoid offending local agricultural businesses. Results should be useful in planning an educational intervention for editors. Meanwhile, public health practitioners should provide concise press releases to their local newspapers about their activities. Also, greater expressions of appreciation from public health professionals and other readers may lead to higher prioritization of nutrition-related stories, and ultimately to an environment more supportive of healthy eating. © 2014 Society for Public Health Education.

  8. Conflicts of interest in biomedical publications: considerations for authors, peer reviewers, and editors

    PubMed Central

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Akazhanov, Nurbek A.; Kitas, George D.

    2013-01-01

    This article overviews evidence on common instances of conflict of interest (COI) in research publications from general and specialized fields of biomedicine. Financial COIs are viewed as the most powerful source of bias, which may even distort citation outcomes of sponsored publications. The urge to boost journal citation indicators by stakeholders of science communication is viewed as a new secondary interest, which may compromize the interaction between authors, peer reviewers, and editors. Comprehensive policies on disclosure of financial and non-financial COIs in scholarly journals are presented as proxies of their indexing in evidence-based databases, and examples of successful medical journals are discussed in detail. Reports on clinical trials, systematic reviews, meta-analyses, and clinical practice guidelines may be unduly influenced by author-pharmaceutical industry relations, but these publications do not always contain explicit disclosures to allow the readers to judge the reliability of the published conclusions and practice-changing recommendations. The article emphasizes the importance of adhering to the guidance on COI from learned associations such as the International Committee of Medical Journal Editors (ICMJE). It also considers joint efforts of authors, peer reviewers, and editors as a foundation for appropriately defining and disclosing potential COIs. PMID:24382859

  9. [Stanisława Adamowiczowa--first editor in-chief of Journal "Przeglad Epidemiologiczny"].

    PubMed

    Gromulska, Marta

    2010-01-01

    First issue of Epidemiological Review was published in 1920. First editor in chief was Stanisława Adamowiczowa, PhD (1888-1965), who had worked in National Central Epidemiological Institute since 1919, and later, for period of 45 years, interrupted by breaks resulting from political situation, worked in National Institute of Hygiene. In this jubilee article, we present scientific resume of S. Adamowiczowa which focuses on her achievements in infectious diseases epidemiology, and particularly in analysis and evaluation of current epidemiological data distribution in Poland and worldwide in the period. She was the pioneer in systemic organization of registries of new cases of diseases in the highly populated Polish cities; she initiated use of statistical methods in this field. As editor in chief of Epidemiological Review, she started publishing Epidemiological Chronicle, which is continuously added as a supplement to every second issue, each year. Name of S. Adamowiczowa is associated with Ludwik Rajchman--director of Hygiene Section in League of Nations, with Witold Chodźko PhD--she led courses in National School of Hygiene in Warsaw, with prof. Marcin Kacprzak--as co-author and co-editor of books on hygiene and epidemiology. A brief list of scientific publications of S. Adamowiczowa is also presented.

  10. Conflicts of interest in biomedical publications: considerations for authors, peer reviewers, and editors.

    PubMed

    Gasparyan, Armen Yuri; Ayvazyan, Lilit; Akazhanov, Nurbek A; Kitas, George D

    2013-12-01

    This article overviews evidence on common instances of conflict of interest (COI) in research publications from general and specialized fields of biomedicine. Financial COIs are viewed as the most powerful source of bias, which may even distort citation outcomes of sponsored publications. The urge to boost journal citation indicators by stakeholders of science communication is viewed as a new secondary interest, which may compromize the interaction between authors, peer reviewers and editors. Comprehensive policies on disclosure of financial and non-financial COIs in scholarly journals are presented as proxies of their indexing in evidence-based databases, and examples of successful medical journals are discussed in detail. Reports on clinical trials, systematic reviews, meta-analyses and clinical practice guidelines may be unduly influenced by author-pharmaceutical industry relations, but these publications do not always contain explicit disclosures to allow the readers to judge the reliability of the published conclusions and practice-changing recommendations. The article emphasizes the importance of adhering to the guidance on COI from learned associations such as the International Committee of Medical Journal Editors (ICMJE). It also considers joint efforts of authors, peer reviewers and editors as a foundation for appropriately defining and disclosing potential COIs.

  11. How is research publishing going to progress in the next 20 years? Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Seattle on Wednesday, 20 March 2013.

    PubMed

    Eaton, K A; Holland, G R; Giannobile, W V; Hancocks, S; Robinson, P G; Lynch, C D

    2014-05-01

    On March 20th 2013, a one-hour session for Editors, Associate Editors, Publishers and others with an interest in scientific publishing was held at the IADR International Session in Seattle. Organised by Kenneth Eaton and Chris Lynch (Chair and Secretary, respectively, of the British Dental Editors Forum), the meeting sought to bring together leading international experts in dental publishing, as well as authors, reviewers and students engaged in research. The meeting was an overwhelming success, with more than 100 attendees. A panel involving four leading dental editors led a discussion on anticipated developments in publishing dental research with much involvement and contribution from audience members. This was the third such meeting held at the IADR for Editors, Associate Editors, Publishers and others with an interest in scientific publishing. A follow up session will take place in Cape Town on 25 June 2014 as part of the annual IADR meeting. The transcript of the meeting is reproduced in this article. Where possible speakers are identified by name. At the first time of mention their role/ position is also stated, thereafter only their name appears. We are grateful to Stephen Hancocks Ltd for their generous sponsorship of this event. For those who were not able to attend the authors hope this article gives a flavour of the discussions and will encourage colleagues to attend future events. Involvement is open to Editors, Associate Editors, Publishers and others with an interest in scientific publishing. It is a very open group and all those with an interest will be welcome to join in.

  12. How is research publishing going to progress in the next 20 years?: transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Seattle on Wednesday, 20 March 2013.

    PubMed

    Eaton, Kenneth A; Rex Holland, G; Giannobile, William V; Hancocks, Stephen; Robinson, Peter G; Lynch, Christopher D

    2014-03-01

    On March 20th 2013, a one-hour session for Editors, Associate Editors, Publishers and others with an interest in scientific publishing was held at the IADR International Session in Seattle. Organised by Kenneth Eaton and Christopher Lynch (Chair and Secretary, respectively, of the British Dental Editors Forum), the meeting sought to bring together leading international experts in dental publishing, as well as authors, reviewers and students engaged in research. The meeting was an overwhelming success, with more than 100 attendees. A panel involving four leading dental editors led a discussion on anticipated developments in publishing dental research with much involvement and contribution from audience members. This was the third such meeting held at the IADR for Editors, Associate Editors, Publishers and others with an interest in scientific publishing. A follow-up session will take place in Cape Town on 25 June 2014 as part of the annual IADR meeting. The transcript of the Seattle meeting is reproduced in this article. Where possible speakers are identified by name. At the first time of mention their role/position is also stated, thereafter only their name appears. We are grateful to Stephen Hancocks Ltd. for their generous sponsorship of this event. For those who were not able to attend the authors hope this article gives a flavour of the discussions and will encourage colleagues to attend future events. Involvement is open to Editors, Associate Editors, Publishers and others with an interest in scientific publishing. It is a very open group and all those with an interest will be welcome to join in.

  13. Letters to the editor in response to studies of guns in the home and homicide and suicide.

    PubMed

    Wiebe, Douglas J; Flynn, Kalen; Branas, Charles C

    2017-12-01

    Letters to the editor are an important venue for scientific discussion and ensuring accountability of authors and editors. We investigated the content and tone of letters to the editor published in response to research on having a firearm in the home as it relates to homicide and suicide. A recent meta-analysis found 16 analytic studies of household firearm access and homicide and suicide. We audited the letters to the editor emanating from those 16 articles. Each letter was coded for themes by two raters and analyzed using descriptive statistics and cluster analysis. For comparison, we also coded and analyzed the content of letters to the editor written in response to all other articles that were published in the same journal volumes where the firearm articles appeared. We identified 30 letters regarding the gun in the home studies: 24 (80%) letters to the editor and 6 (20%) replies from original authors. Of the 24 letters to the editor, 30% contained no scientific discussion, 46% made a political reference, 17% criticized the original author's character, and 25% criticized the journal. Moreover, 29% made a pro-gun reference, 25% made an anti-gun reference, 13% referred to the constitutional right to bear arms, 13% referred to the National Rifle Association (NRA), and 0% referred to advocacy organizations known to be in opposition to the NRA. Of these themes mentioned in letters to the editor, only the NRA was mentioned in a response by an original author. The median number of scientific citations in letters to the editor was one versus four in replies from original authors. In the articles on topics other than firearms that were analyzed as a point of comparison, only 8% contained no scientific discussion, 4% made a political reference, 2% criticized the authors' character, and 0% criticized the journal. Letters to the editor in response to epidemiologic research on guns in the home contain considerable content that minimally advances scientific discussion

  14. 2012 Special NSREC Issue of the IEEE Transactions on Nuclear Science Comments by the Editors

    NASA Astrophysics Data System (ADS)

    Schwank, Jim; Brown, Dennis; Girard, Sylvain; Gouker, Pascale; Gerardin, Simone; Quinn, Heather; Barnaby, Hugh

    2012-12-01

    The December 2012 special issue of the IEEE Transactions on Nuclear Science contains selected papers from the 49th annual IEEE International Nuclear and Space Radiation Effects Conference (NSREC) held July 16–20, 2012, in Miami, Florida USA. 95 papers presented at the 2012 NSREC were submitted for consideration for this year’s special issue. Those papers that appear in this special issue were able to successfully complete the review process before the deadline for the December issue. A few additional papers may appear in subsequent issues of the TRANSACTIONS. This publication is the premier archival journal for research on space and nuclear radiation effects in materials, devices, circuits, and systems. This distinction is the direct result of the conscientious efforts of both the authors, who present and document their work, and the reviewers, who selflessly volunteer their time and talent to help review the manuscripts. Each paper in this journal has been reviewed by experts selected by the editors for their expertise and knowledge of the particular subject areas. The peer review process for a typical technical journal generally takes six months to one year to complete. To publish this special issue of the IEEE Transactions on Nuclear Science (in December), the review process, from initial submission to final form, must be completed in about 10 weeks. Because of the short schedule, both the authors and reviewers are required to respond very quickly. The reviewers listed on the following pages contributed vitally to this quick-turn review process.We would like to express our sincere appreciation to each of them for accepting this difficult, but critical role in the process. To provide consistent reviews of papers throughout the year, the IEEE Transactions on Nuclear Science relies on a year-round editorial board that manages reviews for submissions throughout the year to the TRANSACTIONS in the area of radiation effects. The review process is managed by a

  15. Section Editors

    NASA Astrophysics Data System (ADS)

    Groep, D. L.; Bonacorsi, D.

    2014-06-01

    1. Data Acquisition, Trigger and Controls Niko NeufeldCERNniko.neufeld@cern.ch Tassos BeliasDemokritosbelias@inp.demokritos.gr Andrew NormanFNALanorman@fnal.gov Vivian O'DellFNALodell@fnal.gov 2. Event Processing, Simulation and Analysis Rolf SeusterTRIUMFseuster@cern.ch Florian UhligGSIf.uhlig@gsi.de Lorenzo MonetaCERNLorenzo.Moneta@cern.ch Pete ElmerPrincetonpeter.elmer@cern.ch 3. Distributed Processing and Data Handling Nurcan OzturkU Texas Arlingtonnurcan@uta.edu Stefan RoiserCERNstefan.roiser@cern.ch Robert IllingworthFNAL Davide SalomoniINFN CNAFDavide.Salomoni@cnaf.infn.it Jeff TemplonNikheftemplon@nikhef.nl 4. Data Stores, Data Bases, and Storage Systems David LangeLLNLlange6@llnl.gov Wahid BhimjiU Edinburghwbhimji@staffmail.ed.ac.uk Dario BarberisGenovaDario.Barberis@cern.ch Patrick FuhrmannDESYpatrick.fuhrmann@desy.de Igor MandrichenkoFNALivm@fnal.gov Mark van de SandenSURF SARA sanden@sara.nl 5. Software Engineering, Parallelism & Multi-Core Solveig AlbrandLPSC/IN2P3solveig.albrand@lpsc.in2p3.fr Francesco GiacominiINFN CNAFfrancesco.giacomini@cnaf.infn.it Liz SextonFNALsexton@fnal.gov Benedikt HegnerCERNbenedikt.hegner@cern.ch Simon PattonLBNLSJPatton@lbl.gov Jim KowalkowskiFNAL jbk@fnal.gov 6. Facilities, Infrastructures, Networking and Collaborative Tools Maria GironeCERNMaria.Girone@cern.ch Ian CollierSTFC RALian.collier@stfc.ac.uk Burt HolzmanFNALburt@fnal.gov Brian Bockelman U Nebraskabbockelm@cse.unl.edu Alessandro de SalvoRoma 1Alessandro.DeSalvo@ROMA1.INFN.IT Helge MeinhardCERN Helge.Meinhard@cern.ch Ray PasetesFNAL rayp@fnal.gov Steven GoldfarbU Michigan Steven.Goldfarb@cern.ch

  16. Editors' note

    NASA Astrophysics Data System (ADS)

    Denker, Carsten; Feller, Alex; Schmidt, Wolfgang; von der Lühe, Oskar

    2012-11-01

    This topical issue of Astronomische Nachrichten/Astronomical Notes is a collection of reference articles covering the GREGOR solar telescope, its science capabilities, its subsystems, and its dedicated suite of instruments for high-resolution observations of the Sun. Because ground-based telescopes have life spans of several decades, it is only natural that they continuously reinvent themselves. Literally, the GREGOR telescope builds on the foundations of the venerable Gregory-Coudé Telescope (GCT) at Observatorio del Teide, Tenerife, Spain. Acknowledging the fact that new discoveries in observational solar physics are driven by larger apertures to collect more photons and to scrutinize the Sun in finer detail, the GCT was decommissioned and the building was made available to the GREGOR project.

  17. Editors' note

    NASA Astrophysics Data System (ADS)

    2007-03-01

    This issue of Astronomische Nachrichten is a collection of original papers on local helioseismology, which covers topics discussed at the first HELAS local helioseismology workshop held on 2006 September 25-27 at Nice Observatory, France.

  18. Editor's Note

    NASA Astrophysics Data System (ADS)

    2016-10-01

    In the article "Indian summer monsoon rainfall: Dancing with the tunes of the sun", published in New Astronomy 35 (2015) 8, it was omitted to state that at the time this article was submitted the author Dr. Willie Soon received funding from the Southern Company Services under agreement for SAO Proposal PS0182-9-11. We have no indication that this funding has influenced the results presented in the article.

  19. Editors' note

    NASA Astrophysics Data System (ADS)

    2015-03-01

    The widespread eutrophication of coastal waters clearly involves increased nitrogen loads, in most cases with nitrogen derived from human activities on contributing watersheds. This has prompted regulators, managers, and other stakeholders to set standards for water quality that involve lowering nitrogen loads to estuaries and other coastal waters. To carry out the proscribed lowering of nitrogen loads there are a number of options. In many instances and sites with high human density and intense activity, advanced wastewater treatment plants are unavoidable, but such environmental engineering approaches are costly. There are many coastal zones with lower population densities where other, less costly alternative strategies might be less expensive and more attuned to "green" approaches.

  20. Editor's Introduction.

    ERIC Educational Resources Information Center

    Cozzens, Susan E.

    1986-01-01

    Offers perspectives and ideas on a range of issues related to policy-relevant research in science studies. Identifies and discusses major challenges and problems involved in science policy studies. Presents an overview of articles that address the theme of funding and knowledge growth. (ML)

  1. Editor comments

    NASA Astrophysics Data System (ADS)

    Gouker, Pascale; Ferlet-Cavrois, Véronique; Pellish, Jonathan

    2013-06-01

    This June 2013 Special Issue of the IEEE TRANSACTIONS ON NUCLEAR SCIENCE commemorates the 50th Anniversary of the IEEE International Nuclear and Space Radiation Effects Conference (NSREC). At the NSREC, held annually in July, scientists and engineers from industry, academia, and government institutions present their latest research on radiation effects in materials, electronic devices, circuits, and systems. The conference is the primary forum for technical presentations in the area of radiation effects, with attendance from over 20 countries around the world. It is also an important venue for companies to present their latest products and where students, young graduates, and experienced professionals meet, share ideas, and plan new experiments. Indeed, NSREC has been at the heart of the radiation effects community for 50 years. This special issue consists of review articles summarizing the research that has been published over the past ten years on subjects of interest to this community. The range of topics covered attests to our diversified and rich background.

  2. Editor's note

    NASA Astrophysics Data System (ADS)

    2005-11-01

    Nordita, the Nordic Institute for Theoretical Physics, was founded in 1957 by Niels Bohr and Torsten Gustafsson at Blegdamsvej in Copenhagen, joint to Bohr's legendary Institute. Today, memories of Bohr and his famous visitors -- Albert Einstein, Werner Heisenberg, Lev Landau and many others -- strongly contribute to Nordita's genius loci and inspire next generations of her visitors. Nordita awards ``Nordic Project'' grants to individual Nordic physicists to help conduct a world-class research in Nordic countries (Denmark, Finland, Island, Norway, and Sweden). Research reported here was generously supported by the Nordic Project "Quasi Periodic Oscillations in Black Hole and Neutron Star sources" awarded in 2005 to Marek Abramowicz. The Project supported the ``Nordita Workdays on QPO" (March 25 -- April 1, 2005) organized by Marek Abramowicz, Axel Brandenburg and Juri Poutanen with help of Hanne Bergen, Helle http://www.nordita.dk/positions/norproject.html

  3. Editor's note

    NASA Astrophysics Data System (ADS)

    2016-02-01

    In the Invited Feature Article in this issue of Estuarine, Coastal and Shelf Science, Ruben Kosyan and Violeta Velikova describe the disastrous anthropogenic impact on the Black Sea coast of Bulgaria, Georgia, Romania, Russian Federation, Turkey, and Ukraine over the last 100 years and its inverse correlation with economic development as exemplified by improving water quality during a downturn in the economy. This degradation is now accelerating from the renovation and construction of ports and terminals, the development of resorts, hazardous industrial development, oil and gas exploration, and unsustainable agricultural and fishing practices. There appears to be no enforcement of protected areas. In the absence of scientific research on these issues, coastal zone management appears to be based on 'learning after seeing disastrous effects'. Without recognition of the need for Integrated Coastal Zone Management, the Black Sea coast and the coastal waters will deteriorate, as was observed between the 1970s and the 1990s.

  4. Editors' note

    NASA Astrophysics Data System (ADS)

    2014-12-01

    The widespread eutrophication of coastal waters has been the subject to much scientific and management effort, yet we have too few examples where there is a substantive scientific record, and sustained tracking of management actions. In this issue Greening and colleagues review the time courses of ambient conditions, describe what was done to remediate severely eutrophic water quality, and demonstrate the recovery trajectory of a number of variables useful to track ecosystem responses. In addition, a compelling aspect of the paper is that it also describes the social side of the recovery, i.e., what was needed to bring the community and political action to perceive and act upon the issues, and develop a plan to address the problems. The improvement in water quality and environmental conditions currently taking place in Tampa Bay is an excellent example of what can be achieved with the combination of basic understanding of the scientific issues, application of reasonable technological advances, and the marshaling of popular support for action.

  5. Editor's Notes.

    ERIC Educational Resources Information Center

    Smetana, Judith G.

    1994-01-01

    Introduces the articles in this journal issue, noting the burgeoning interest in the roots of parental beliefs, values, and goals. Highlights thematic continuities among the otherwise diverse research approaches presented, for example, synthesis of different theoretical perspectives of parent beliefs, or the context in which parental beliefs…

  6. Editor's note

    NASA Astrophysics Data System (ADS)

    2014-08-01

    Progress in marine sciences often follows the development of new methods. The Invited Feature Article "New Insight into Particulate Mineral and Organic Matter in Coastal Ocean Waters through Optical Inversion" by Xiaodong Zhang, Robert Hans Stavn, Alexander U. Falster, Deric J. Gray, and Richard W. Gould demonstrates a new method that uses scattering and transmissometer data to differentiate between particle size distribution of suspended mineral and that of suspended organic matter. The method helps define the particular groups of phytoplankton that may be dominant, whether organic detritus may be more significant in suspended organic matter, add insight on the dominant size classes of mineral aggregates, and helps differentiate between organic detritus-dominated systems and biogenic-dominated systems.

  7. Editor's Note.

    PubMed

    Alberts, Bruce

    2011-05-27

    The Research Article "A bacterium that can grow by using arsenic instead of phosphorus" by F. Wolfe-Simon et al., published online 2 December 2010, was the subject of extensive discussion and criticism following its online publication. Science received a wide range of correspondence that raised specific concerns about the Research Article's methods and interpretations. Eight Technical Comments that represent the main concerns, as well as a Technical Response by Wolfe-Simon et al., are published online in Science Express at the addresses listed in this note. They have been peer-reviewed and revised according to Science's standard procedure.

  8. Editors' foreword

    Treesearch

    D.C. Hayes; S.L. Stout; R.H. Crawford; A.P. Hoover

    2014-01-01

    Research programs may move in new directions in response to changes in society's needs and values. Each chapter of this book reflects the relationship between the ecological results that emerge from a long-term research project and the social forces that influence questions asked and resources invested in ecological research.

  9. Saha equation, single and two particle states

    NASA Technical Reports Server (NTRS)

    Kraeft, W. D.; Girardeau, M. D.; Strege, B.

    1990-01-01

    Single- and two-particle properties in a dense plasma are discussed in connection with their role in the mass action law for a partially ionized plasma. The two-particle-bound states are nearly density independent, while the continuum is essentially shifted. The single-particle states are damped, and their energy has a negative shift and a parabolic behavior for small momenta.

  10. New Editor-in-Chief for Journal of Physics A: Mathematical and Theoretical

    NASA Astrophysics Data System (ADS)

    Gillan, Rebecca

    2014-04-01

    We are delighted to announce that Professor Martin Evans of University of Edinburgh has been appointed as the new Editor-in-Chief of Journal of Physics A: Mathematical and Theoretical. Martin Evans has been Editor of the Statistical Physics section of the journal since 2009. Prior to this, he served as a Board Member for the journal. His areas of research include statistical mechanics of nonequilibrium systems, phase transitions and scaling regimes in nonequilibrium statistical physics, glassy dynamics, phase transitions and ordering in driven diffusive systems, mass transport models, condensation models, zero range processes and exclusion processes. We very much look forward to working with Martin to continue to improve the journal's quality and interest to the readership. We would like to thank our outgoing Editor-in-Chief, Professor Murray Batchelor. Murray has worked hard and provided excellent guidance in improving the quality of the journal and the service that the journal provides to authors, referees and readers. During the last five years, we have raised the quality threshold for acceptance in the journal and currently reject over 70% of submissions. As a result, papers published in Journal of Physics A: Mathematical and Theoretical are amongst the best in the field. We have also maintained and improved on our excellent receipt-to-first-decision times, which now average under 40 days for papers. With the help of Martin Evans and our distinguished Editorial Board, we will be working to further improve the quality of the journal whilst continuing to offer excellent services to our readers, authors and referees. We hope that you benefit from reading the journal. If you have any comments or questions, please do not hesitate to contact us at jphysa@iop.org. Rebecca Gillan Publisher

  11. Creating OGC Web Processing Service workflows using a web-based editor

    NASA Astrophysics Data System (ADS)

    de Jesus, J.; Walker, P.; Grant, M.

    2012-04-01

    The OGC WPS (Web Processing Service) specifies how geospatial algorithms may be accessed in an SOA (Service Oriented Architecture). Service providers can encode both simple and sophisticated algorithms as WPS processes and publish them as web services. These services are not only useful individually but may be built into complex processing chains (workflows) that can solve complex data analysis and/or scientific problems. The NETMAR project has extended the Web Processing Service (WPS) framework to provide transparent integration between it and the commonly used WSDL (Web Service Description Language) that describes the web services and its default SOAP (Simple Object Access Protocol) binding. The extensions allow WPS services to be orchestrated using commonly used tools (in this case Taverna Workbench, but BPEL based systems would also be an option). We have also developed a WebGUI service editor, based on HTML5 and the WireIt! Javascript API, that allows users to create these workflows using only a web browser. The editor is coded entirely in Javascript and performs all XSLT transformations needed to produce a Taverna compatible (T2FLOW) workflow description which can be exported and run on a local Taverna Workbench or uploaded to a web-based orchestration server and run there. Here we present the NETMAR WebGUI service chain editor and discuss the problems associated with the development of a WebGUI for scientific workflow editing; content transformation into the Taverna orchestration language (T2FLOW/SCUFL); final orchestration in the Taverna engine and how to deal with the large volumes of data being transferred between different WPS services (possibly running on different servers) during workflow orchestration. We will also demonstrate using the WebGUI for creating a simple workflow making use of published web processing services, showing how simple services may be chained together to produce outputs that would previously have required a GIS (Geographic

  12. Multistate Model Builder (MSMB): a flexible editor for compact biochemical models

    PubMed Central

    2014-01-01

    Background Building models of molecular regulatory networks is challenging not just because of the intrinsic difficulty of describing complex biological processes. Writing a model is a creative effort that calls for more flexibility and interactive support than offered by many of today’s biochemical model editors. Our model editor MSMB — Multistate Model Builder — supports multistate models created using different modeling styles. Results MSMB provides two separate advances on existing network model editors. (1) A simple but powerful syntax is used to describe multistate species. This reduces the number of reactions needed to represent certain molecular systems, thereby reducing the complexity of model creation. (2) Extensive feedback is given during all stages of the model creation process on the existing state of the model. Users may activate error notifications of varying stringency on the fly, and use these messages as a guide toward a consistent, syntactically correct model. MSMB default values and behavior during model manipulation (e.g., when renaming or deleting an element) can be adapted to suit the modeler, thus supporting creativity rather than interfering with it. MSMB’s internal model representation allows saving a model with errors and inconsistencies (e.g., an undefined function argument; a syntactically malformed reaction). A consistent model can be exported to SBML or COPASI formats. We show the effectiveness of MSMB’s multistate syntax through models of the cell cycle and mRNA transcription. Conclusions Using multistate reactions reduces the number of reactions need to encode many biochemical network models. This reduces the cognitive load for a given model, thereby making it easier for modelers to build more complex models. The many interactive editing support features provided by MSMB make it easier for modelers to create syntactically valid models, thus speeding model creation. Complete information and the installation package can be

  13. Funding source and conflict of interest disclosures by authors and editors in gastroenterology specialty journals revisited.

    PubMed

    Qureshi, J; Sud, A; Vakil, N

    2012-03-01

    A survey of journals published in the field of Gastroenterology conducted 5 years ago showed marked variability in reporting of conflicts of interest or funding sources in these journals. To re-examine reporting of conflicts of interest and funding sources for original articles and editorials in Gastroenterology and Hepatology journals. We evaluated all original articles and editorials in 15 leading journals (determined by impact factor-Thomson Reuter Science Citation Index) devoted to Gastroenterology and Hepatology for disclosures of conflicts and for editor's self disclosures. We examined each journal's editorial policy by contacting the journal directly if the information was not revealed on the Web site or print versions of the journal. Of the 1574 articles evaluated, a total of 1207 (77%) reported the presence or absence of a potential conflict of interest and 1047 (67%) reported the presence or absence of funding sources. A total of 3 of the 15 (20%) journals (American Journal of Gastroenterology, Gastroenterology, and Alimentary Pharmacology and Therapeutics reported the presence or absence of funding sources in all their published original articles. Only 5 of 15 (33%) journals (Gut, Gastrointestinal Endoscopy, American Journal of Gastroenterology, Neurogastroenterology & Motility and Alimentary Pharmacology and Therapeutics) publicly disclosed the conflicts of interest of the editors. (i) Funding sources and conflicts of interest are still reported variably in the GI literature. (ii) Editorials and review articles are influential, but have poor reporting of conflicts of interest. (iii) Editors of many journals still do not report their conflicts of interest. © 2012 Blackwell Publishing Ltd.

  14. The publication of ethically uncertain research: attitudes and practices of journal editors.

    PubMed

    Angelski, Carla; Fernandez, Conrad V; Weijer, Charles; Gao, Jun

    2012-04-11

    Publication of ethically uncertain research occurs despite well-published guidelines set forth in documents such as the Declaration of Helsinki. Such guidelines exist to aide editorial staff in making decisions regarding ethical acceptability of manuscripts submitted for publication, yet examples of ethically suspect and uncertain publication exist. Our objective was to survey journal editors regarding practices and attitudes surrounding such dilemmas. The Editor-in-chief of each of the 103 English-language journals from the 2005 Abridged Index Medicus list publishing original research were asked to complete a survey sent to them by email between September-December 2007. A response rate of 33% (n = 34) was obtained from the survey. 18% (n = 6) of respondents had published ethically uncertain or suspect research within the last 10 years. 85% (n = 29) of respondents stated they would always reject ethically uncertain articles submitted for publication on ethical grounds alone. 12% (n = 4) of respondents stated they would approach each submission on a case-by-case basis. 3% (n = 1) stated they would be likely to publish such research, but only with accompanying editorial. Only 38% (n = 13) give reviewers explicit instruction to reject submissions on ethical grounds if found wanting. Editorial compliance with the Declaration of Helsinki in rejecting research that is conducted unethically was difficult to ascertain because of a poor response rate despite multiple attempts using different modalities. Of those who did respond, the majority do reject ethically suspect research but few explicitly advise reviewers to do so. In this study editors did not take advantage of the opportunity to describe their support for the rejection of the publication of unethical research.

  15. Correcting the record of structural publications requires joint effort of the community and journal editors.

    PubMed

    Rupp, Bernhard; Wlodawer, Alexander; Minor, Wladek; Helliwell, John R; Jaskolski, Mariusz

    2016-12-01

    Seriously flawed and even fictional models of biomolecular crystal structures, although rare, still persist in the record of structural repositories and databases. The ensuing problems of database contamination and persistence of publications based on incorrect structure models must be effectively addressed. The burden cannot be simply left to the critical voices who take the effort to contribute dissenting comments that are mostly ignored. The entire structural biology community, and particularly the journal editors who exercise significant power in this respect, must engage in a constructive dialog lest structural biology lose its credibility as an evidence-based empirical science.

  16. Quality and peer review of research: an adjudicating role for editors.

    PubMed

    Newton, Douglas P

    2010-05-01

    Peer review gives research a stamp of approval, but the reviews themselves can be flawed. This is potentially serious for the writer, the journal, and journal user. This study describes shortcomings of the peer review process and condenses them into an explanatory framework involving situational, personal, social, and ethical factors. Some proposals to improve matters are impractical and may make them worse. Some data is offered which illustrates the problem and suggests a potential solution. Informed editors who avoid mechanical approaches engage cautiously and critically with reviews and guard against bias, even in themselves, could make a significant difference.

  17. From the Editors: Assessing the International Journal of Exercise Science after Two Years

    PubMed Central

    LYONS, T. SCOTT; NAVALTA, JAMES W.

    2010-01-01

    The popularity of the International Journal of Exercise Science continues to rise. As a student-focused journal, we are pleased to provide these future professionals with opportunities to gain experience with the peer review process, both through submitting their original work and as manuscript reviewers. Our editorial process is changing as section editors with specialties within the field of exercise science have agreed to take on these responsibilities. In addition, we are proud to also publish conference proceedings from various meetings held around the world. A list of individuals who have reviewed manuscripts throughout the last year is included. PMID:27182323

  18. [Frequency and characteristics of letters to the editor published in Farmacia Hospitalaria (1995-2006)].

    PubMed

    Rosell Pradas, J; Lacasaña Navarro, M

    2007-01-01

    To describe the frequency and bibliographical characteristics of letters to the editor published in the Farmacia Hospitalaria journal (hospital pharmacy) between 1995 and 2006. Descriptive and comprehensive study on documents classified as letters to the editor, which were published between 1995 and 2006. Using journal issues as a source, the following variables were identified: number of letters/year, main content, text length (words), language, use of graphs, number of authors and their professional experience, number of participating institutions, origin in terms of autonomous community, number of bibliographical references and their origin. Descriptive statistics were used. A total of 82 letters were identified, with a mean of 7 per year and 1.1 per journal. They were more frequent during the last two years, 43 (52%) of the total, following their practical non-existence between 1998 and 2003. The majority of the letters, 52 (63%), were regarding clinical cases while 23 (28%) were related to publications or were replies to the letters themselves. All letters met the requirements regarding text length, language and use of graphs. The mean number of authors was 3, and in 12 letters (14%) the limit on the number of authors was exceeded. In 56 cases (64%), the letters were written by hospital pharmacists only, however 26 (32%) were written in conjunction with hospital doctors. In 16 of the letters (20%), the authors belonged to one or more institutions. The letters mainly came from Valencia, Catalonia, Madrid and Andalusia. A total of 411 supporting references were gathered. The mean was 5 citations per letter to the editor, between 0 and 15 references, and in 17 cases (21%), the number of references was higher than the accepted limit. Of the total citations, 255 (60%) were from foreign publications. Letters to the editor in Farmacia Hospitalaria significantly increased during the last two years of the period studied and were practically non-existent before this. It

  19. Parallel public spheres: distance and discourse in letters to the editor.

    PubMed

    Perrin, Andrew J; Vaisey, Stephen

    2008-11-01

    This article examines letters to the editor as one of the ways citizens seek to enact a public sphere using technological mediation. Using a sample of all letters received by a metropolitan newspaper during a three-month period (N = 1,113), the authors demonstrate that the tone and argumentative styles of letters differ with the scope of the issues the letters address. Local issues evoke more reasoned, conciliatory tones, while issues beyond the local context evoke more emotional, confrontational tones, even after controlling for individual writers' characteristics and anger as a motivation to write.

  20. Virtual reality and claustrophobia: multiple components therapy involving game editor virtual environments exposure.

    PubMed

    Malbos, E; Mestre, D R; Note, I D; Gellato, C

    2008-12-01

    The effectiveness of a multiple components therapy regarding claustrophobia and involving virtual reality (VR) will be demonstrated through a trial which immersed six claustrophobic patients in multiple context-graded enclosed virtual environments (VE) using affordable VR apparatus and software. The results of the questionnaires and behavior tests exhibited a significant reduction in fear towards the enclosed space and quality of life improvement. Such gains were maintained at 6-month follow-up. Presence score indicated the patients felt immersed and present inside the game editor VE.

  1. Advanced software development workstation. Engineering scripting language graphical editor: DRAFT design document

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Engineering Scripting Language (ESL) is a language designed to allow nonprogramming users to write Higher Order Language (HOL) programs by drawing directed graphs to represent the program and having the system generate the corresponding program in HOL. The ESL system supports user generation of HOL programs through the manipulation of directed graphs. The components of this graphs (nodes, ports, and connectors) are objects each of which has its own properties and property values. The purpose of the ESL graphical editor is to allow the user to create or edit graph objects which represent programs.

  2. Improving the quality of papers submitted to dental journals: Transcription of session for editors, associate editors, publishers and others with an interest in scientific publishing held at IADR meeting in Cape Town on Wednesday, 25 June 2014.

    PubMed

    Eaton, Kenneth A; Giannobile, William V; Sourgen, Deborah L; Balaji, S M; Honkala, Eino; Lynch, Christopher D

    2015-08-01

    This satellite symposium was the fourth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday 25th June 2014 at the IADR International meeting in Cape Town, South Africa. The symposium attracted more than 180 attendees. This symposium placed an emphasis on how the quality of papers submitted to dental journals could be improved. The panel included representation from editors, researchers and publishers from North America, India and the Gulf States. The symposium identified a number of challenges for editors and publishers, including the poor quality of many papers submitted to dental and other scientific journals, plagiarism, attempted duplicate publication and sometimes fraudulent results. Where possible speakers are identified by name. A subsequent symposium was held during the IADR meeting in Boston on March 11th 2015. Involvement open to editors, associate editors, publishers and others with an interest in scientific publishing. Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.

  3. [Revista Médica de Chile: A new member in the "International Committee of Medical Journal Editors"].

    PubMed

    Reyes, Humberto

    2010-06-01

    After a worldwide call for applications that took place in 2009, two medical journals were selected to become new members of the "International Committee of Medical Journal Editors (ICMJE)": Chinese Medical Journal and Revista Médica de Chile. Both Editors: Getu Zhaori, MD, and Humberto Reyes, MD, respectively, attended the ICMJE Meeting, 12-14 April 2010, in Queenstown, New Zealand. The meeting agenda included several topics that had been studied in advance by the attendants: editors or deputy editors of the 14 journals integrating this Committee plus a representative for the U.S. National Library of Medicine and another one for the World Association of Medical Journal Editors (WAME). The Committee agreed in new recommendations tending to safeguard the integrity and transparency of every manuscript published in all journals that adhere to the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals (URM)". These recommendations will be published shortly in ICMJE member journals. An important issue discussed refers to improvements in the "ICMJE Uniform Disclosure Form for Potential Conflicts of Interest"' that had some changes, a glossary of terms will be attached to it and the Instructions will be accompanied by translations into the official WHO languages as well as other languages used by ICMJE member journals. For our journal it is an honor and a great responsibility to become a member of this highly qualified Committee, the only journal published in Spanish and the first one from Latin America.

  4. Semi-automated XML markup of biosystematic legacy literature with the GoldenGATE editor.

    PubMed

    Sautter, Guido; Böhm, Klemens; Agosti, Donat

    2007-01-01

    Today, digitization of legacy literature is a big issue. This also applies to the domain of biosystematics, where this process has just started. Digitized biosystematics literature requires a very precise and fine grained markup in order to be useful for detailed search, data linkage and mining. However, manual markup on sentence level and below is cumbersome and time consuming. In this paper, we present and evaluate the GoldenGATE editor, which is designed for the special needs of marking up OCR output with XML. It is built in order to support the user in this process as far as possible: Its functionality ranges from easy, intuitive tagging through markup conversion to dynamic binding of configurable plug-ins provided by third parties. Our evaluation shows that marking up an OCR document using GoldenGATE is three to four times faster than with an off-the-shelf XML editor like XML-Spy. Using domain-specific NLP-based plug-ins, these numbers are even higher.

  5. AliView: a fast and lightweight alignment viewer and editor for large datasets.

    PubMed

    Larsson, Anders

    2014-11-15

    AliView is an alignment viewer and editor designed to meet the requirements of next-generation sequencing era phylogenetic datasets. AliView handles alignments of unlimited size in the formats most commonly used, i.e. FASTA, Phylip, Nexus, Clustal and MSF. The intuitive graphical interface makes it easy to inspect, sort, delete, merge and realign sequences as part of the manual filtering process of large datasets. AliView also works as an easy-to-use alignment editor for small as well as large datasets. AliView is released as open-source software under the GNU General Public License, version 3.0 (GPLv3), and is available at GitHub (www.github.com/AliView). The program is cross-platform and extensively tested on Linux, Mac OS X and Windows systems. Downloads and help are available at http://ormbunkar.se/aliview anders.larsson@ebc.uu.se Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

  6. Ontology-Based Controlled Natural Language Editor Using CFG with Lexical Dependency

    NASA Astrophysics Data System (ADS)

    Namgoong, Hyun; Kim, Hong-Gee

    In recent years, CNL (Controlled Natural Language) has received much attention with regard to ontology-based knowledge acquisition systems. CNLs, as subsets of natural languages, can be useful for both humans and computers by eliminating ambiguity of natural languages. Our previous work, OntoPath [10], proposed to edit natural language-like narratives that are structured in RDF (Resource Description Framework) triples, using a domain-specific ontology as their language constituents. However, our previous work and other systems employing CFG for grammar definition have difficulties in enlarging the expression capacity. A newly developed editor, which we propose in this paper, permits grammar definitions through CFG-LD (Context-Free Grammar with Lexical Dependency) that includes sequential and semantic structures of the grammars. With CFG describing the sequential structure of grammar, lexical dependencies between sentence elements can be designated in the definition system. Through the defined grammars, the implemented editor guides users' narratives in more familiar expressions with a domain-specific ontology and translates the content into RDF triples.

  7. René Marcelle (December 30, 1931-December 18, 2011), the first editor-in-chief of Photosynthesis Research.

    PubMed

    Govindjee; Marcelle, Dominique

    2016-07-01

    This tribute honors the first editor-in-chief of Photosynthesis Research, René Marcelle the Belgian plant physiologist who, with publishers in The Netherlands, launched the journal in 1980. Here, we present a glimpse of René Marcelle's early life, his education and research, as well as his editorial work for the journal and other conferences in plant physiology. He worked on control of photosynthesis, both the biological and environmental aspects, as well as on crassulacean acid metabolism. He is best remembered as a kind-hearted and humane editor.

  8. Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files

    SciTech Connect

    Randolph Schwarz; Leland L. Carter; Alysia Schwarz

    2005-08-23

    Monte Carlo N-Particle Transport Code (MCNP) is the code of choice for doing complex neutron/photon/electron transport calculations for the nuclear industry and research institutions. The Visual Editor for Monte Carlo N-Particle is internationally recognized as the best code for visually creating and graphically displaying input files for MCNP. The work performed in this grant was used to enhance the capabilities of the MCNP Visual Editor to allow it to read in both 2D and 3D Computer Aided Design (CAD) files, allowing the user to electronically generate a valid MCNP input geometry.

  9. Korean association of medical journal editors at the forefront of improving the quality and indexing chances of its member journals.

    PubMed

    Suh, Chang-Ok; Oh, Se Jeong; Hong, Sung-Tae

    2013-05-01

    The article overviews some achievements and problems of Korean medical journals published in the highly competitive journal environment. Activities of Korean Association of Medical Journal Editors (KAMJE) are viewed as instrumental for improving the quality of Korean articles, indexing large number of local journals in prestigious bibliographic databases and launching new abstract and citation tracking databases or platforms (eg KoreaMed, KoreaMed Synapse, the Western Pacific Regional Index Medicus [WPRIM]). KAMJE encourages its member journals to upgrade science editing standards and to legitimately increase citation rates, primarily by publishing more great articles with global influence. Experience gained by KAMJE and problems faced by Korean editors may have global implications.

  10. The Editors' Recollections on the Occasion of the 60th Anniversary of The American Journal of Human Genetics

    PubMed Central

    2009-01-01

    Volume 1, Number 1 of The American Journal of Human Genetics was published in September 1949. The first paper was an 18-page preface to the journal by H. J. Muller, president of The American Society of Human Genetics, entitled “Progress and Prospects in Human Genetics.” Charles W. Cotterman served as the first editor, and since that time a dozen other human geneticists have shared that distinction. In recognition of the 60th anniversary of AJHG, recollections of five editors are recorded here.

  11. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors’ Network

    PubMed Central

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Dei Cas, Livio; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; J. Filipiak, Krzysztof; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J. J.; Varga, Albert; Lüscher, Thomas F.

    2017-01-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship- emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors’ Network of the European Society of Cardiology. PMID:28630534

  12. Wikipedia and medicine: quantifying readership, editors, and the significance of natural language.

    PubMed

    Heilman, James M; West, Andrew G

    2015-03-04

    Wikipedia is a collaboratively edited encyclopedia. One of the most popular websites on the Internet, it is known to be a frequently used source of health care information by both professionals and the lay public. This paper quantifies the production and consumption of Wikipedia's medical content along 4 dimensions. First, we measured the amount of medical content in both articles and bytes and, second, the citations that supported that content. Third, we analyzed the medical readership against that of other health care websites between Wikipedia's natural language editions and its relationship with disease prevalence. Fourth, we surveyed the quantity/characteristics of Wikipedia's medical contributors, including year-over-year participation trends and editor demographics. Using a well-defined categorization infrastructure, we identified medically pertinent English-language Wikipedia articles and links to their foreign language equivalents. With these, Wikipedia can be queried to produce metadata and full texts for entire article histories. Wikipedia also makes available hourly reports that aggregate reader traffic at per-article granularity. An online survey was used to determine the background of contributors. Standard mining and visualization techniques (eg, aggregation queries, cumulative distribution functions, and/or correlation metrics) were applied to each of these datasets. Analysis focused on year-end 2013, but historical data permitted some longitudinal analysis. Wikipedia's medical content (at the end of 2013) was made up of more than 155,000 articles and 1 billion bytes of text across more than 255 languages. This content was supported by more than 950,000 references. Content was viewed more than 4.88 billion times in 2013. This makes it one of if not the most viewed medical resource(s) globally. The core editor community numbered less than 300 and declined over the past 5 years. The members of this community were half health care providers and 85

  13. Wikipedia and Medicine: Quantifying Readership, Editors, and the Significance of Natural Language

    PubMed Central

    West, Andrew G

    2015-01-01

    Background Wikipedia is a collaboratively edited encyclopedia. One of the most popular websites on the Internet, it is known to be a frequently used source of health care information by both professionals and the lay public. Objective This paper quantifies the production and consumption of Wikipedia’s medical content along 4 dimensions. First, we measured the amount of medical content in both articles and bytes and, second, the citations that supported that content. Third, we analyzed the medical readership against that of other health care websites between Wikipedia’s natural language editions and its relationship with disease prevalence. Fourth, we surveyed the quantity/characteristics of Wikipedia’s medical contributors, including year-over-year participation trends and editor demographics. Methods Using a well-defined categorization infrastructure, we identified medically pertinent English-language Wikipedia articles and links to their foreign language equivalents. With these, Wikipedia can be queried to produce metadata and full texts for entire article histories. Wikipedia also makes available hourly reports that aggregate reader traffic at per-article granularity. An online survey was used to determine the background of contributors. Standard mining and visualization techniques (eg, aggregation queries, cumulative distribution functions, and/or correlation metrics) were applied to each of these datasets. Analysis focused on year-end 2013, but historical data permitted some longitudinal analysis. Results Wikipedia’s medical content (at the end of 2013) was made up of more than 155,000 articles and 1 billion bytes of text across more than 255 languages. This content was supported by more than 950,000 references. Content was viewed more than 4.88 billion times in 2013. This makes it one of if not the most viewed medical resource(s) globally. The core editor community numbered less than 300 and declined over the past 5 years. The members of this

  14. EDITORIAL: A few words from the new Editor-in-Chief A few words from the new Editor-in-Chief

    NASA Astrophysics Data System (ADS)

    Margaritondo, Giorgio

    2011-04-01

    As I begin my mandate as Editor-in-Chief of Journal of Physics D: Applied Physics, I can look back with great pleasure at many years of service, as a member of the Editorial Board, to this outstanding instrument of scientific dissemination. Having witnessed the exceptional quantitative and qualitative growth of the journal, I must consider this appointment both an honour and a real challenge. The success of the journal is primarily based on three assets: the authors' talent of course, but also the illuminated leadership of my predecessors at the journal helm and the highly competent, dedicated and responsive staff. I would like to praise, in particular, the leadership of my immediate predecessor and good friend, Pallab Battacharya, the pilot of the years of major qualitative growth. Being Pallab's successor makes my new responsibility even more challenging! The IOP personnel is a key asset for the journal: in my rather broad experience in scientific publishing, I have never seen such a combination of professional experience, commitment and willingness to innovate—a traditional strength of JPD. Regrettably, I cannot acknowledge here all the women and men who contributed to the success of the journal; however, I would like to explicitly acknowledge the outstanding work of Sarah Quin over the past decade. In my new duty, I can fortunately count on her successor, Olivia Roche, whose excellent professional and managerial qualities we can already appreciate. How should we view the future of the journal? In my view, with reasonable optimism. Notwithstanding the tough competition, our journal has a solid reputation and increasing visibility. It has consistently belonged to the small elite group of top journals preferred by applied physics authors worldwide. My program as Editor-in-Chief is both simple and very testing: to continue to enhance this elite status. The challenge comes from a variety of factors: first, 'applied physics' is a continuously evolving notion, even

  15. How to write a medical original article: Advice from an Editor

    PubMed Central

    Shokeir, Ahmed A.

    2013-01-01

    Objectives To provide guidelines for potential authors on how to increase the chances of their manuscript being accepted, with a review focusing on writing an original medical article. Methods This review reflects the personal experience of the present author, who has extensive experience as an author, reviewer and editor. Results To write an original article successfully, there are three essential requirements, the ‘basic triad’ of an original article. These are subjects worth reporting, knowledge of the basic structure of an article, and knowledge of the essential mechanics of good writing. This review details each of the three items. Conclusions Writing, like every other art, cannot be learned wholly from books or lectures, but can be learned largely by experience. The best training is to start the task and persevere. The act of writing, like surgical techniques, must be learned the hard way, by practice and perseverance. Anyone can start writing but only a good writer can finish the task. PMID:26019929

  16. JOSPT Experiences Tremendous Growth, Change in 14 Years With Editor-in-Chief Simoneau in Charge.

    PubMed

    Nyland, John A

    2015-12-01

    As Editor-in-Chief, Dr Guy G. Simoneau and his editorial board have taken JOSPT from an acceptable US-based journal to a highly influential worldwide force behind contemporary orthopaedic and sports physical therapy research and practice. Today, the bridge Dr Simoneau constructed spans the orthopaedic and sports physical therapy globe for the betterment of clinical practice and research. His work fully supports JOSPT's latest strategic plan to provide value-added knowledge translation, develop a broader authorship and readership, increase global marketing of the JOSPT brand, and expand current relationships to new partners and stakeholders. The bridge places JOSPT on very firm footing, tying its rich history to the promise of an exciting and successful future.

  17. Predatory journals: una amenaza emergente para autores y editores de publicaciones biomédicas.

    PubMed

    Delgado-López, Pedro David; Corrales-García, Eva María

    2017-09-28

    So-called predatory publishing is a new and rising phenomenon presenting as an intellectual fraud that jeopardises the quality of scientific contribution, compromises the activity of authors, reviewers and editors of legitimate journals, damages the image of open access publications and is a very profitable business. In this paper, we review the concept and relevance of predatory journals and the characteristics that differentiate them from legitimate publications. Neurosurgical and general neuroscience journals are not immune to this problem. Academic institutions and ethics committees have a duty to raise awareness of this phenomenon and provide information and support to authors and the whole scientific community to avoid its propagation and potential control of biomedical publishing. Copyright © 2017 Sociedad Española de Neurocirugía. Publicado por Elsevier España, S.L.U. All rights reserved.

  18. The CROWN initiative: journal editors invite researchers to develop core outcomes in women's health.

    PubMed

    Khan, Khalid; Belizán, José M

    2014-07-21

    Clinical trials, systematic reviews and guidelines compare beneficial and non-beneficial outcomes following interventions. Often, however, various studies on a particular topic do not address the same outcomes, making it difficult to draw clinically useful conclusions when a group of studies is looked at as a whole. This problem was recently thrown into sharp focus by a systematic review of interventions for preterm birth prevention, which found that among 103 randomised trials, no fewer than 72 different outcomes were reported. There is a growing recognition among clinical researchers that this variability undermines consistent synthesis of the evidence, and that what is needed is an agreed standardised collection of outcomes - a "core outcomes set" - for all trials in a specific clinical area. Recognising that the current inconsistency is a serious hindrance to progress in our specialty, the editors of over 50 journals related to women's health have come together to support The CROWN (CoRe Outcomes in WomeN's health) Initiative.

  19. Seqotron: a user-friendly sequence editor for Mac OS X.

    PubMed

    Fourment, Mathieu; Holmes, Edward C

    2016-02-17

    Accurate multiple sequence alignment is central to bioinformatics and molecular evolutionary analyses. Although sophisticated sequence alignment programs are available, manual adjustments are often required to improve alignment quality. Unfortunately, few programs offer a simple and intuitive way to edit sequence alignments. We present Seqotron, a sequence editor that reads and writes files in a wide variety of sequence formats. Sequences can be easily aligned and manually edited using the mouse and keyboard. The program also allows the user to estimate both phylogenetic trees and distance matrices. Seqotron will benefit researchers who need to manipulate and align complex sequence data. Seqotron is a Mac OS X compatible open source project and is available from Github https://github.com/4ment/seqotron/.

  20. Interview with Future Medicinal Chemistry's US Senior Editor, Iwao Ojima. Interview by Issac Bruce.

    PubMed

    Ojima, Iwao

    2012-10-01

    Professor Iwao Ojima studied at the University of Tokyo (Japan) before being appointed as a Senior Research Fellow and Group Leader at the Sagami Institute of Chemical Research. He is now Director of the Institute of Chemical Biology and Drug Discovery at State University of New York (USA) and has been a visiting professor in European, North American and Asian academic institutions. Professor Ojima agreed to serve as the US Senior Editor of Future Medicinal Chemistry when it launched in 2009 and continues to provide his expertise to the journal. Professor Ojima spoke to Future Medicinal Chemistry about why medicinal chemistry is such an exciting field to work in, the state of the pharmaceutical industry, and what features and issues make this journal unique.