[Cartography and geographical spread of the adventitious species of brome (Bromus spp.) among cereals in the Sais area of Morocco].

PubMed

Hamal, A; Benbella, M; Rzozi, S B; Bouhache, M; Msatef, Y

2001-01-01

Bromus spp is causing serious problems in wheat in the Sais area. However, the damage of this weed varies from one region to another according to the agro-climatic conditions and crop systems. The characterization of the infestation level in each situation is a prerequisite to develop a control strategy adapted to each environment. This study was undertaken in order to determine the infestation level and geographical spread of the weedy brome (Bromus spp) on wheat in Sais following crop systems and pedo-climatic conditions. The results obtained during two consecutive years (1998-99 and 1999-2000) revealed that ripgut brome (Bromus rigidus Roth.) was the most dominant species in wheat fields in the surveyed regions, followed by B. rubens L., B. sterilis L., B. madritensis L. and B. mollus L. Among, 18 regions and 100 infested wheat fields, 16.67% of fields were slightly infested (Plant density of Bromus (Dbr < 90 plants/m2, 61.11% were moderately infested (90 < Dbr < 290 plants/m2) and 22.22% were highly infested (Dbr > 400 plants/m2). The maximum relative frequency was obtained with Bromus rigidus (47.15%) and the coverage was 40.43%. But, for B.rubens, B. madritensis and B. sterilis, the relative frequencies were respectively 31.42; 26 and 15% and their coverages were respectively 28.9, 20.4 and 12.5%.

Plio-Pleistocene facies environments from the KBS Member, Koobi Fora Formation: implications for climate controls on the development of lake-margin hominin habitats in the northeast Turkana Basin (northwest Kenya).

PubMed

Lepre, Christopher J; Quinn, Rhonda L; Joordens, Josephine C A; Swisher, Carl C; Feibel, Craig S

2007-11-01

Climate change is hypothesized as a cause of major events of Plio-Pleistocene East African hominin evolution, but the vertically discontinuous and laterally confined nature of the relevant geological records has led to difficulties with assessing probable links between the two. High-resolution sedimentary sequences from lacustrine settings can provide comprehensive data of environmental changes and detailed correlations with well-established orbital and marine records of climate. Hominin-bearing deposits from Koobi Fora Ridge localities in the northeast Turkana Basin of Kenya are an archive of Plio-Pleistocene lake-margin sedimentation though significant developmental junctures of northern African climates, East African environments, and hominin evolution. This study examines alluvial channel and floodplain, nearshore lacustrine, and offshore lacustrine facies environments for the approximately 136-m-thick KBS Member (Koobi Fora Formation) exposed at the Koobi Fora Ridge. Aspects of the facies environments record information on the changing hydrosedimentary dynamics of the lake margin and give insights into potential climatic controls. Seasonal/yearly climate changes are represented by the varve-like laminations in offshore mudstones and the slickensides, dish-shaped fractures, and other paleosol features overprinted on floodplain strata. Vertical shifts between facies environments, however, are interpreted to indicate lake-level fluctuations deriving from longer-term, dry-wet periods in monsoonal rainfall. Recurrence periods for the inferred lake-level changes range from about 10,000 to 50,000 years, and several are consistent with the average estimated timescales of orbital precession ( approximately 20,000 years) and obliquity ( approximately 40,000 years). KBS Member facies environments from the Koobi Fora Ridge document the development of lake-margin hominin habitats in the northeast Turkana Basin. Environmental changes in these habitats may be a result of

SAI (Systems Applications, Incorporated) Urban Airshed Model. Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schere, K.L.

1985-06-01

This magnetic tape contains the FORTRAN source code, sample input data, and sample output data for the SAI Urban Airshed Model (UAM). The UAM is a 3-dimensional gridded air-quality simulation model that is well suited for predicting the spatial and temporal distribution of photochemical pollutant concentrations in an urban area. The model is based on the equations of conservation of mass for a set of reactive pollutants in a turbulent-flow field. To solve these equations, the UAM uses numerical techniques set in a 3-D finite-difference grid array of cells, each about 1 to 10 kilometers wide and 10 to severalmore » hundred meters deep. As output, the model provides the calculated pollutant concentrations in each cell as a function of time. The chemical species of prime interest included in the UAM simulations are O3, NO, NO/sub 2/ and several organic compounds and classes of compounds. The UAM system contains at its core the Airshed Simulation Program that accesses input data consisting of 10 to 14 files, depending on the program options chosen. Each file is created by a separate data-preparation program. There are 17 programs in the entire UAM system. The services of a qualified dispersion meteorologist, a chemist, and a computer programmer will be necessary to implement and apply the UAM and to interpret the results. Software Description: The program is written in the FORTRAN programming language for implementation on a UNIVAC 1110 computer under the UNIVAC 110 0 operating system level 38R5A. Memory requirement is 80K.« less

Safety and efficacy of first-line bevacizumab combination therapy in Chinese population with advanced non-squamous NSCLC: data of subgroup analyses from MO19390 (SAiL) study.

PubMed

Zhou, C C; Bai, C X; Guan, Z Z; Jiang, G L; Shi, Y K; Wang, M Z; Wu, Y L; Zhang, Y P; Zhu, Y Z

2014-05-01

Bevacizumab is a monoclonal antibody with high antitumor activity against malignant diseases. Previous studies have demonstrated the efficacy of first-line bevacizumab combination therapy in advanced, non-squamous non-small cell lung cancer (NS-NSCLC). SAiL (MO19390), an open-label, multicenter, single-arm study, evaluated the safety and efficacy of first-line bevacizumab-based treatment in clinical practice. This report presents the results of a subgroup analysis of Chinese patients enrolled in SAiL. Chemo-naive Chinese patients with locally advanced, metastatic or recurrent NSCLC were randomized to receive Bev 15 mg/kg every 3 weeks plus carboplatin + paclitaxel for maximum of six cycles, followed by single-agent bevacizumab until disease progression. The primary endpoint was safety. Secondary endpoints included time to progression and overall survival. The Chinese intent-to-treat (ITT) population consists of 198 Chinese patients, among whom 107 (54 %) were non-smokers and 90 (45.5 %) were female. The median cycle of bevacizumab administration was 10 and median duration of bevacizumab treatment was 29.5 weeks. Only eight cases of severe adverse events were observed in the study, which were deemed to be related to bevacizumab. The incidence of AEs over grade 3 in Chinese ITT patients was generally low (<9 %). No new safety signals were reported. Objective response rate in 195 evaluable Chinese patients was 68.8 %, including four complete responses (2.1 %). Time to disease progression (TTP) and overall survival were 8.8 and 18.5 months, respectively. The safety and efficacy of first-line bevacizumab-based treatment in Chinese population with advanced NS-NSCLC are consistent with those in previous studies as well as in Asian subgroup population from SAiL study. No new safety signals were reported.

[The relic in the Panels of São Vicente de Fora].

PubMed

Goyri-O'Neill, João; Camisão-Soares, Artur; Neves Marques, Cláudia

2013-01-01

The Panels of São Vicente de Fora, a polyptych dated from 1470 to 1480, are a work composed of 6 panels, authored by Nuno Gonçalves, a painter of King Afonso V. This work reveals one of the most remarkable collective portraits of European painting, making this polyptych an inexhaustible source of readings and interpretations, fueling a secular controversy. The present work aims analyzing precise an iconographic anatomical image repainted in the 6th panel, or the panel of the Relic. This consists of a central image within a structure shown by a red figure with special reverence. The investigation conducted and justification was based on direct observation and comparative analysis of iconographic data collected in the Museum of Antique Art. The bone pieces were selected at the Museum of Anatomy, Department of Anatomy, Faculty of Medical Sciences, New University of Lisbon, and the comparative analyses performed by two observers, with further analysis of the images obtained in the National Museum of Ancient Art using specific software. After watching these, it was concluded that this representation of a relic in the Panels of São Vicente is an iconic representation of an Occipital bone, fractured at its lower edge, being evident, almost complete, its vertical portion or scale.

Ionic liquid and aqueous two-phase extraction based on salting-out coupled with high-performance liquid chromatography for the determination of seven rare ginsenosides in Xue-Sai-Tong injection.

PubMed

Li, Lan-Jie; Jin, Yong-Ri; Wang, Xiao-Zhong; Liu, Ying; Wu, Qian; Shi, Xiao-Lei; Li, Xu-Wen

2015-09-01

A method of ionic liquid salt aqueous two-phase extraction coupled with high-performance liquid chromatography has been developed for the analysis of seven rare ginsenosides including Rg6 , F4 , 20(S)-Rg3 , 20(R)-Rg3 , Rk3 , Rk1 , and Rg5 in Xue-Sai-Tong injection. The injection was mixed with ionic liquid 1-butyl-3-methylimidazolium bromide aqueous solution, and a mixture was obtained. With the addition of sodium dodecyl sulfate and dipotassium phosphate into the mixture, the aqueous two-phase mixture was formed after ultrasonic treatment and centrifuged. Rare ginsenosides were extracted into the upper phase. To obtain a high extraction factors, various influences were considered systematically, such as the volume of ionic liquid, the category and amount of salts, the amount of sodium dodecyl sulfate, the pH value of system, and the time of ultrasonic treatment. Under the optimal condition, rare ginsenosides in Xue-Sai-Tong injection were enriched and detected, the recoveries of seven rare ginsenosides ranged from 90.05 to 112.55%, while relative standard deviations were lower than 2.50%. The developed method was reliable, rapid and sensitive for the determination of seven rare ginsenosides in the injections. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Preliminary Monitoring of Soil gas Radon in Potentially Active Faults, San Sai District, Chiang Mai Province, Thailand

NASA Astrophysics Data System (ADS)

Pondthai, P.; Udphuay, S.

2013-05-01

The magnitude of 5.1 Mw earthquake occurred in San Sai District, Chiang Mai Province, Thailand in December 2006 was considered an uncommon event due to the fact that there was no statistical record of such significant earthquake in the area. Therefore the earthquake might have been associated with a potentially active fault zone within the area. The objective of this study is to measure soil gas radon across this unknown fault zone within the Chiang Mai Basin, northern Thailand. Two profiles traversing the expected fault zone of soil gas radon measurements have been monitored, using TASTRAK solid state track nuclear detectors (SSNTDs). Radon signals from three periods of measurement show a distinctive consistent spatial distribution pattern. Anomalous radon areas along the profiles are connected to fault locations previously interpreted from other geophysical survey results. The increased radon signal changes from the radon background level with the signal-to-background ratio above 3 are considered anomalous. Such pattern of radon anomaly supports the existence of the faults. The radon measurement, therefore is a powerful technique in mapping active fault zone.

Neurological adverse events temporally associated to mass vaccination against yellow fever in Juiz de Fora, Brazil, 1999-2005.

PubMed

Fernandes, Guilherme Côrtes; Camacho, Luiz Antonio Bastos; Sá Carvalho, Marilia; Batista, Maristela; de Almeida, Sonia Maria Rodrigues

2007-04-20

The identification of adverse events following immunization (AEFI) and their prompt investigation are important to allow a timely and scientifically based response to the users of immunization services. This article presents an analysis of notified AEFI cases between 1999 and 2005 and their temporal association with 2001 yellow fever vaccination campaign, AEFI notification attributed to yellow fever vaccination rose from 0.06 to 1.32 per 100,000 vaccinees in Brazil, between 1998 and 2000. During the 2001 yellow fever mass vaccination campaign held in Juiz de Fora, Brazil, 12 cases of aseptic meningitis were temporally associated to yellow fever vaccination, but clinical and laboratory data were not available to confirm nor deny causality. Epidemiological studies associated to enhanced surveillance and standardized protocols should take advantage of public health interventions like mass vaccination campaigns and implementation of new vaccination strategies in order to assess and investigate vaccine safety.

Zinc isotope ratios of bones and teeth as new dietary indicators: results from a modern food web (Koobi Fora, Kenya)

NASA Astrophysics Data System (ADS)

Jaouen, Klervia; Beasley, Melanie; Schoeninger, Margaret; Hublin, Jean-Jacques; Richards, Michael P.

2016-05-01

In order to explore the possibilities of using zinc (Zn) stable isotope ratios as dietary indicators, we report here on the measurements of the ratio of stable isotopes of zinc (66Zn/64Zn, expressed here as δ66Zn) in bioapatite (bone and dental enamel) of animals from a modern food web in the Koobi Fora region of the Turkana Basin in Kenya. We demonstrate that δ66Zn values in both bone and enamel allow a clear distinction between carnivores and herbivores from this food web. Differences were also observed between browsers and grazers as well as between carnivores that consumed bone (i.e. hyenas) compared to those that largely consume flesh (i.e. lions). We conclude that Zn isotope ratio measurements of bone and teeth are a new and promising dietary indicator.

Tritium ((3)H) as a tracer for monitoring the dispersion of conservative radionuclides discharged by the Angra dos Reis nuclear power plants in the Piraquara de Fora Bay, Brazil.

PubMed

de Carvalho Gomes, Franciane; Godoy, José Marcus; de Carvalho, Zenildo Lara; de Souza, Elder Magalhães; Rodrigues Silva, José Ivan; Tadeu Lopes, Ricardo

2014-10-01

Presently, two nuclear power plants operate in Brazil. Both are located at Itaorna beach, Angra dos Reis, approximately 133 km from Rio de Janeiro city. The reactor cooling circuits require the input of seawater, which is later discharged through a pipeline into the adjacent Piraquara de Fora Cove. The radioactive effluents undergo ion-exchange treatment prior to their release in batches, causing the enrichment of (3)H relative to other radionuclides in the discharged waters. Under steady state conditions, the (3)H gradient in the Piraquara de Fora waters can be used to determine the dependence of the dilution factor on the distance from the discharge point. The present work describes experiments carried out at the reactor site during batch release episodes, including time series sampling at the discharge point and surface seawater sampling every 250 m to a distance of 1250 m, after a double distillation, the (3)H concentration was measured by liquid scintillation counting applying a Quantulus liquid scintillation spectrometer. The obtained results showed a linear relationship between the (3)H concentration and distance from the discharge point. At 1250 m from the discharge point a dilution index of 1:15 was measured which fits the expected value based on modeling. Copyright © 2014 Elsevier Ltd. All rights reserved.

Urban renewal based wind environment at pedestrian level in high-density and high-rise urban areas in Sai Ying Pun, Hong Kong

NASA Astrophysics Data System (ADS)

Yao, J. W.; Zheng, J. Y.; Zhao, Y.; Shao, Y. H.; Yuan, F.

2017-11-01

In high-density and high-rise urban areas, pedestrian level winds contribute to improve comfort, safety and diffusion of heat in urban areas. Outdoor wind study is extremely vital and a prerequisite in high-density cities considering that the immediate pedestrian level wind environment is fundamentally impacted by the presence of a series of high-rise buildings. In this paper, the research site of Sai Ying Pun in Hong Kong will be analysed in terms of geography, climate and urban morphology, while the surrounding natural ventilation has also been simulated by the wind tunnel experiment Computational Fluid Dynamics (CFD). It has found that, the existing problems in this district are the contradiction between planning control and commercial interests, which means some areas around tall buildings are not benefit to the residents because of the unhealthy wind environment. Therefore, some recommendation of urban renewal strategy has been provided.

The evolution of the international system of radiological protection: stakeholder views from the 1st and 2nd NEA/ICRP fora.

PubMed

Lazo, Ted

2003-12-01

The Nuclear Energy Agency's (NEA's) Committee on Radiological Protection and Public Health (CRPPH) has collaborated closely with the ICRP in its efforts to develop new recommendations for radiological protection at the start of the 21st century. As part of this effort, the NEA organised, in collaboration with the ICRP, two fora to discuss the radiological protection of the environment (Taormina, February 2002) and the future policy for radiological protection (Lanzarote, April 2003). Both these meetings were attended by a broad representation of stakeholders. The CRPPH and other stakeholders universally appreciated the opportunity to speak directly with the ICRP on these important subjects. This report summarises the main conclusions made during these two meetings to advance the deliberations of the ICRP to create a new set of recommendations responsive to stakeholder needs, firmly rooted in science, and that can be implemented in a timely, efficient and cost-effective manner.

Effects of high pressure processing on activity and structure of soluble acid invertase in mango pulp, crude extract, purified form and model systems.

PubMed

Li, Renjie; Wang, Yongtao; Ling, Jiangang; Liao, Xiaojun

2017-09-15

The effects of high pressure processing (HPP) on the activity of soluble acid invertase (SAI) in mango pulp, crude extract, purified SAI and purified SAI in model systems (pectin, bovine serum albumin (BSA), sugars and pH 3-7) were investigated. The activity of SAI in mango pulp was increased after HPP, and that in crude extract stayed unchanged. The activity of purified SAI was decreased after HPP at 45 and 50°C. Pectin exhibited a concentration-dependent protection for purified SAI against HPP at 50°C/600MPa for 30min. Pectin that had an esterification degree (DE) of 85% exhibited a greater protection than pectin that had a DE of 20-34%. BSA, acidic pH (3-6) and sucrose also exhibited protection for purified SAI against HPP. HPP at 50°C/600MPa for 30min disrupted the secondary structure and tertiary structure of purified SAI, but no aggregation of purified SAI was observed after HPP. Copyright © 2017 Elsevier Ltd. All rights reserved.

Meteorological conditions at the Caucasus Observatory of the SAI MSU from the results of the 2007-2015 campaign

NASA Astrophysics Data System (ADS)

Kornilov, V. G.; Kornilov, M. V.; Shatsky, N. I.; Vozyakova, O. V.; Gorbunov, I. A.; Safonov, B. S.; Potanin, S. A.; Cheryasov, D. V.; Senik, V. A.

2016-09-01

Based on the measurements performed from 2007 to 2015 at the summit of Mount Shatdzhatmaz adjacent to the 2.5-m telescope at the Caucasus Observatory of the SAI MSU, we have determined the statistical characteristics of basic meteorological parameters: the ambient air temperature, the ground wind speed, and the relative humidity. The stability of these parameters over the entire period of our measurements and their variations within an annual cycle have been studied. The median temperature on clear nights is +3.2°C, although there are nights with a temperature below -15°C. The typical ground wind speed is 3 m s-1; the probability of a wind stronger than 10 m s-1 does not exceed 2%. The losses of observing time due to high humidity are maximal in the summer period but, on the whole, are small over a year, less than 10%. We have estimated the absolute water vapor content in the atmosphere, which is especially important for infrared observations. Minimum precipitablewater vapor is observed in December-February; the median value over these months is 5 mm. We additionally provide the wind speeds at various altitudes above the ground (from 1 to 16 km) that we obtained when measuring the optical turbulence. We present the results and technique of our measurements of the annual amount of clear night astronomical time, which is, on average, 1320 h, i.e., 45% of the possible one at the latitude of the observatory. The period from mid-September to mid-March accounts for about 70% of the clear time. A maximum of clear skies is observed in November, when its fraction reaches 60% of the possible astronomical night time.

Use of social adaptability index to explain self-care and diabetes outcomes.

PubMed

Campbell, Jennifer A; Walker, Rebekah J; Smalls, Brittany L; Egede, Leonard E

2017-06-20

To examine whether the social adaptability index (SAI) alone or components of the index provide a better explanatory model for self-care and diabetes outcomes. Six hundred fifteen patients were recruited from two primary care settings. A series of multiple linear regression models were run to assess (1) associations between the SAI and diabetes self-care/outcomes, and (2) associations between individual SAI indicator variables and diabetes self-care/outcomes. Separate models were run for each self-care behavior and outcome. Two models were run for each dependent variable to compare associations with the SAI and components of the index. The SAI has a significant association with the mental component of quality of life (0.23, p < 0.01). In adjusted analyses, the SAI score did not have a significant association with any of the self-care behaviors. Individual components from the index had significant associations between self-care and multiple SAI indicator variables. Significant associations also exist between outcomes and the individual SAI indicators for education and employment. In this population, the SAI has low explanatory power and few significant associations with diabetes self-care/outcomes. While the use of a composite index to predict outcomes within a diabetes population would have high utility, particularly for clinical settings, this SAI lacks statistical and clinical significance in a representative diabetes population. Based on these results, the index does not provide a good model fit and masks the relationship of individual components to diabetes self-care and outcomes. These findings suggest that five items alone are not adequate to explain or predict outcomes for patients with type 2 diabetes.

Variability in effective radiating area and output power of new ultrasound transducers at 3 MHz.

PubMed

Johns, Lennart D; Straub, Stephen J; Howard, Samuel M

2007-01-01

Spatial average intensity (SAI) is often used by clinicians to gauge therapeutic ultrasound dosage, yet SAI measures are not directly regulated by US Food and Drug Administration (FDA) standards. Current FDA guidelines permit a possible 50% to 150% minimum to maximum range of SAI values, potentially contributing to variability in clinical outcomes. To measure clinical values that describe ultrasound transducers and to determine the degree of intramanufacturer and intermanufacturer variability in effective radiating area, power, and SAI when the transducer is functioning at 3 MHz. A descriptive and interferential approach was taken to this quasi-experimental design. Measurement laboratory. Sixty-six 5-cm(2) ultrasound transducers were purchased from 6 different manufacturers. All transducers were calibrated and then assessed using standardized measurement techniques; SAI was normalized to account for variability in effective radiating area, resulting in an nSAI. Effective radiating area, power, and nSAI. All manufacturers with the exception of Omnisound (P = .534) showed a difference between the reported and measured effective radiating area values (P < .001). All transducers were within FDA guidelines for power (+/-20%). Chattanooga (0.85 +/- 0.05 W/cm(2)) had a lower nSAI (P < .05) than all other manufacturers functioning at 3 MHz. Intramanufacturer variability in SAI ranged from 16% to 35%, and intermanufacturer variability ranged from 22% to 61%. Clinicians should consider treatment values of each individual transducer, regardless of the manufacturer. In addition, clinicians should scrutinize the power calibration and recalibration record of the transducer and adjust clinical settings as needed for the desired level of heating. Our data may aid in explaining the reported heating differences among transducers from different manufacturers. Stricter FDA standards regarding effective radiating area and total power are needed, and standards regulating SAI should be

Variability in Effective Radiating Area and Output Power of New Ultrasound Transducers at 3 MHz

PubMed Central

Johns, Lennart D; Straub, Stephen J; Howard, Samuel M

2007-01-01

Context: Spatial average intensity (SAI) is often used by clinicians to gauge therapeutic ultrasound dosage, yet SAI measures are not directly regulated by US Food and Drug Administration (FDA) standards. Current FDA guidelines permit a possible 50% to 150% minimum to maximum range of SAI values, potentially contributing to variability in clinical outcomes. Objective: To measure clinical values that describe ultrasound transducers and to determine the degree of intramanufacturer and intermanufacturer variability in effective radiating area, power, and SAI when the transducer is functioning at 3 MHz. Design: A descriptive and interferential approach was taken to this quasi-experimental design. Setting: Measurement laboratory. Patients or Other Participants: Sixty-six 5-cm2 ultrasound transducers were purchased from 6 different manufacturers. Intervention(s): All transducers were calibrated and then assessed using standardized measurement techniques; SAI was normalized to account for variability in effective radiating area, resulting in an nSAI. Main Outcome Measure(s): Effective radiating area, power, and nSAI. Results: All manufacturers with the exception of Omnisound (P = .534) showed a difference between the reported and measured effective radiating area values (P < .001). All transducers were within FDA guidelines for power (±20%). Chattanooga (0.85 ± 0.05 W/cm2) had a lower nSAI (P < .05) than all other manufacturers functioning at 3 MHz. Intramanufacturer variability in SAI ranged from 16% to 35%, and intermanufacturer variability ranged from 22% to 61%. Conclusions: Clinicians should consider treatment values of each individual transducer, regardless of the manufacturer. In addition, clinicians should scrutinize the power calibration and recalibration record of the transducer and adjust clinical settings as needed for the desired level of heating. Our data may aid in explaining the reported heating differences among transducers from different manufacturers

Standardization of renal function evaluation in Wistar rats (Rattus norvegicus) from the Federal University of Juiz de Fora's colony.

PubMed

de Castro, Bárbara Bruna Abreu; Colugnati, Fernando Antonio Basile; Cenedeze, Marcos Antonio; Suassuna, Paulo Giovanni de Albuquerque; Pinheiro, Hélady Sanders

2014-01-01

There is great interest in the use of animal models in the study of renal pathophysiology requires standardization of parameters. Standardize assessment of renal function in rats from in the Center for Reproductive Biology of Federal University of Juiz de Fora's colony. Thirty Wistar rats were used and performed measurements of creatinine (serum and urine), serum urea and proteinuria. Were evaluated: the urine collection interval in metabolic cages (24 hours or 12 hours), the need for 12-hour fast, the need of urine and serum deproteinization for creatinine measurement, need of serum deproteinization in animals with acute kidney injury to a spectrophotometer and ELISA, and the comparison of 24-hour proteinuria (PT 24 hours) with the protein/creatinine ratio (rP/C). Means were compared by the Student's t test, Pearson correlation, Bland-Altman plot for agreement and linear regression model to estimate PT 24 hours from rP/C. The 24 hours urine output was greater than 12 hours, interfering with the creatinine clearance calculation. In the fasting group showed less water intake and lower urinary creatinine. There was great variability for the deproteinized whey and readings performed in the two devices were similar. There was a strong correlation between PT 24 hours and rP/C and the equation was generated: PT 24 hours = (8.6113 x rP/C) + 1.0869. Was standardized: 24-hour urine collection without fasting. The deproteinization showed no benefit. The measurements were performed with spectrophotometer reliability. It generated a practical formula for estimating PT 24 hours through rP/C.

Psychometric properties of the School Anxiety Inventory-Short Version in Spanish secondary education students.

PubMed

García-Fernández, José M; Inglés, Cándido J; Marzo, Juan C; Martínez-Monteagudo, María C

2014-05-01

The School Anxiety Inventory (SAI) can be applied in different fields of psychology. However, due to the inventory's administration time, it may not be useful in certain situations. To address this concern, the present study developed a short version of the SAI (the SAI-SV). This study examined the reliability and validity evidence drawn from the scores of the School Anxiety Inventory-Short Version (SAI-SV) using a sample of 2,367 (47.91% boys) Spanish secondary school students, ranging from 12 to 18 years of age. To analyze the dimensional structure of the SAI-SV, exploratory and confirmatory factor analyses were applied. Internal consistency and test-retest reliability were calculated for SAI-SV scores. A correlated three-factor structure related to school situations (Anxiety about Aggression, Anxiety about Social Evaluation, and Anxiety about Academic Failure) and a three-factor structure related to the response systems of anxiety (Physiological Anxiety, Cognitive Anxiety, and Behavioral Anxiety) were identified and supported. The internal consistency and test-retest reliability were determined to be appropriate. The reliability and validity evidence based on the internal structure of SAI-SV scores was satisfactory.

Developments in environmental auditing by supreme audit institutions.

PubMed

Van Leeuwen, Sylvia

2004-02-01

At the end of the 1980s, Supreme Audit Institutions (SAIs) became aware of their responsibility towards the environment and environmental policy. In this article, the development of environmental auditing by SAIs during the last 10 years is presented, as well as the current state of the art. The description is based on the results of three questionnaire surveys held in 1994, 1997, and 2000 by the INTOSAI Working Group in Environmental Auditing. In most countries, the government has stipulated some form of environmental policy, and the SAI has a mandate to carry out regularity and/or performance audits. The activities of SAIs have developed substantially since 1993. Nowadays, environmental auditing is a substantial and regular part of the audit work of more than half of the SAIs. Environmental problems are often transboundary in nature. SAIs can contribute to international environmental cooperation by auditing the compliance of their national government with international environmental obligations and commitments. The INTOSAI Working Group on environmental auditing wants to enhance this type of audit and has provided guidelines for the audit process and the selection of international agreements. Moreover, cooperation between SAIs is a good method to exchange experiences and to learn from each other.

Stand-level variation in evapotranspiration in non-water-limited eucalypt forests

NASA Astrophysics Data System (ADS)

Benyon, Richard G.; Nolan, Rachael H.; Hawthorn, Sandra N. D.; Lane, Patrick N. J.

2017-08-01

To better understand water and energy cycles in forests over years to decades, measurements of spatial and long-term temporal variability in evapotranspiration (Ea) are needed. In mountainous terrain, plot-level measurements are important to achieving this. Forest inventory data including tree density and size measurements, often collected repeatedly over decades, sample the variability occurring within the geographic and topographic range of specific forest types. Using simple allometric relationships, tree stocking and size data can be used to estimate variables including sapwood area index (SAI), which may be strongly correlated with annual Ea. This study analysed plot-level variability in SAI and its relationship with overstorey and understorey transpiration, interception and evaporation over a 670 m elevation gradient, in non-water-limited, even-aged stands of Eucalyptus regnans F. Muell. to determine how well spatial variation in annual Ea from forests can be mapped using SAI. Over the 3 year study, mean sap velocity in five E. regnans stands was uncorrelated with overstorey sapwood area index (SAI) or elevation: annual transpiration was predicted well by SAI (R2 0.98). Overstorey and total annual interception were positively correlated with SAI (R2 0.90 and 0.75). Ea from the understorey was strongly correlated with vapour pressure deficit (VPD) and net radiation (Rn) measured just above the understorey, but relationships between understorey Ea and VPD and Rn differed between understorey types and understorey annual Ea was not correlated with SAI. Annual total Ea was also strongly correlated with SAI: the relationship being similar to two previous studies in the same region, despite differences in stand age and species. Thus, spatial variation in annual Ea can be reliably mapped using measurements of SAI.

Stochastic reconstructions of spectral functions: Application to lattice QCD

NASA Astrophysics Data System (ADS)

Ding, H.-T.; Kaczmarek, O.; Mukherjee, Swagato; Ohno, H.; Shu, H.-T.

2018-05-01

We present a detailed study of the applications of two stochastic approaches, stochastic optimization method (SOM) and stochastic analytical inference (SAI), to extract spectral functions from Euclidean correlation functions. SOM has the advantage that it does not require prior information. On the other hand, SAI is a more generalized method based on Bayesian inference. Under mean field approximation SAI reduces to the often-used maximum entropy method (MEM) and for a specific choice of the prior SAI becomes equivalent to SOM. To test the applicability of these two stochastic methods to lattice QCD, firstly, we apply these methods to various reasonably chosen model correlation functions and present detailed comparisons of the reconstructed spectral functions obtained from SOM, SAI and MEM. Next, we present similar studies for charmonia correlation functions obtained from lattice QCD computations using clover-improved Wilson fermions on large, fine, isotropic lattices at 0.75 and 1.5 Tc, Tc being the deconfinement transition temperature of a pure gluon plasma. We find that SAI and SOM give consistent results to MEM at these two temperatures.

[Evaluation of ectoparasites and hemoparasites in dogs kept in apartments and houses with yards in the city of Juiz de Fora, Minas Gerais, Brazil].

PubMed

Soares, Aline O; Souza, Aline D; Feliciano, Eveline A; Rodrigues, André F S F; D'Agosto, Marta; Daemon, Erik

2006-01-01

Fleas and ticks transmit various pathogens while feeding on the blood of dogs. This study sought to verify the occurrence of ectoparasitism and hemoparasitism in dogs from two urban areas in the city of Juiz de Fora, Minas Gerais, Brazil. Between February and August 2003, 101 dogs were studied: 50 came from apartments in the downtown region and 51 from houses with grassy yards. The ectoparasites were collected and conserved in etanol 70%. The occurrence of hemoparasites was verified by examining blood smears from sample taken from the dogs'ears. The blood smears were stained with Giemsa and 100 fields per slide were examined, studying the erythrocytes to determine parasitism. From among the dogs living in apartments, we found (with respective prevalence and mean intensity): Ctenocephalides felis (12%), (3.3+/-2.0); Rhipicephalus sanguineus (2%); and ixodid nymphs (2%). In this environment in the dogs were not found hemoparasites. From the houses with grassy yards, we observed the following prevalence levels and mean intensities: C. felis (14%), (2.28+/-1.9); R. sanguineus (35%), (7.8+/-9.8); ixodid nymph (18%), (1.4+/-0.7); and ixodid larvae (4%), (12+/-14.4). The hemoparasites found were: Ehrlichia canis (16%) and Babesia canis (2%).

Social adaptability and substance abuse: Predictors of depression among hemodialysis patients?

PubMed Central

2013-01-01

Background Several aspects linked to social are involved in the onset of depressive feelings. We aimed to find out if social adaptability and substance abuse predict depression among end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Methods We included 145 ESRD patients undergoing HD. Social adaptability was estimated by the Social Adaptability Index (SAI). Substance abuse was defined according to SAI. We screened for depression by applying the 20-item version of the Center for Epidemiologic Studies Depression Scale. A score ≥ 24 classified the patients as depressed. Comparisons between depressed and non-depressed patients were carried out and logistic regression was performed to test gender, age, total SAI, SAI without the substance abuse item, only the substance abuse score and substance abuse as a categorical variable (yes/no) as predictors of depression. Results There were 36 (24.8%) depressed patients. There were no differences regarding demographic and laboratory data between the depressed and non-depressed patients. Mean SAI among depressed and non-depressed patients was, respectively, 6.1 ± 1.6 vs. 6.2 ± 1.9 (p=0.901). The percentage of patients with or without substance abuse among depressed patients was, respectively, 13.8% vs. 13.9% (p=1.000). Gender, age, total SAI, SAI without the substance abuse item, only the substance abuse score and substance abuse as a categorical variable did not predict depression. Conclusions Social adaptability and substance abuse did not predict depression in HD patients. We propose that aspects related to socioeconomic status not comprised in SAI items should be ruled out as predictors of depression. PMID:23320829

On the use of a snow aridity index to predict remotely sensed forest productivity in the presence of bark beetle disturbance

NASA Astrophysics Data System (ADS)

Knowles, John F.; Lestak, Leanne R.; Molotch, Noah P.

2017-06-01

We used multiple sources of remotely sensed and ground based information to evaluate the spatiotemporal variability of snowpack accumulation, potential evapotranspiration (PET), and Normalized Difference Vegetation Index (NDVI) throughout the Southern Rocky Mountain ecoregion, USA. Relationships between these variables were used to establish baseline values of expected forest productivity given water and energy inputs. Although both the snow water equivalent (SWE) and a snow aridity index (SAI), which used SWE to normalize PET, were significant predictors of the long-term (1989-2012) NDVI, SAI explained 11% more NDVI variability than SWE. Deviations from these relationships were subsequently explored in the context of widespread forest mortality due to bark beetles. Over the entire study area, NDVI was lower per unit SAI in beetle-disturbed compared to undisturbed areas during snow-related drought; however, both SAI and NDVI were spatially heterogeneous within this domain. As a result, we selected three focus areas inside the larger study area within which to isolate the relative impacts of SAI and disturbance on NDVI using multivariate linear regression. These models explained 66%-85% of the NDVI and further suggested that both SAI and disturbance effects were significant, although the disturbance effect was generally greater. These results establish the utility of SAI as a measure of moisture limitation in snow-dominated systems and demonstrate a reduction in forest productivity due to bark beetle disturbance that is particularly evident during drought conditions resultant from low snow accumulation during the winter.

Violent extremist group ecologies under stress

PubMed Central

Cebrian, Manuel; Torres, Manuel R.; Huerta, Ramon; Fowler, James H.

2013-01-01

Violent extremist groups are currently making intensive use of Internet fora for recruitment to terrorism. These fora are under constant scrutiny by security agencies, private vigilante groups, and hackers, who sometimes shut them down with cybernetic attacks. However, there is a lack of experimental and formal understanding of the recruitment dynamics of online extremist fora and the effect of strategies to control them. Here, we utilize data on ten extremist fora that we collected for four years to develop a data-driven mathematical model that is the first attempt to measure whether (and how) these external attacks induce extremist fora to self-regulate. The results suggest that an increase in the number of groups targeted for attack causes an exponential increase in the cost of enforcement and an exponential decrease in its effectiveness. Thus, a policy to occasionally attack large groups can be very efficient for limiting violent output from these fora. PMID:23536118

Violent extremist group ecologies under stress.

PubMed

Cebrian, Manuel; Torres, Manuel R; Huerta, Ramon; Fowler, James H

2013-01-01

Violent extremist groups are currently making intensive use of Internet fora for recruitment to terrorism. These fora are under constant scrutiny by security agencies, private vigilante groups, and hackers, who sometimes shut them down with cybernetic attacks. However, there is a lack of experimental and formal understanding of the recruitment dynamics of online extremist fora and the effect of strategies to control them. Here, we utilize data on ten extremist fora that we collected for four years to develop a data-driven mathematical model that is the first attempt to measure whether (and how) these external attacks induce extremist fora to self-regulate. The results suggest that an increase in the number of groups targeted for attack causes an exponential increase in the cost of enforcement and an exponential decrease in its effectiveness. Thus, a policy to occasionally attack large groups can be very efficient for limiting violent output from these fora.

Social Anxiety Scale for Adolescents and School Anxiety Inventory: Psychometric properties in French adolescents.

PubMed

Delgado, Beatriz; García-Fernández, José M; Martínez-Monteagudo, María C; Inglés, Cándido J; Marzo, Juan C; La Greca, Annette M; Hugon, Mandarine

2018-06-02

School and social anxiety are common problems and have a significant impact on youths' development. Nevertheless, the questionnaires to assess these anxious symptoms in French adolescents have limitations. The aim of this study is to provide a French version of the Social Anxiety Scale for Adolescents (SAS-A) and the School Anxiety Inventory (SAI), analysing their psychometric properties by the factor structure, internal consistency, and convergent validity. The SAS-A and the SAI were collectively administered in a sample of 1011 French adolescents (48.5% boys) ranging in age from 11 to 18 years. Confirmatory factor analyses replicated the previously identified correlated three-factor structure of the SAS-A and the correlated four-factor structure of the SAI. Acceptable internal consistency indexes were found for SAS-A and SAI scores. Correlations supported the convergent validity of the questionnaires' subscales. Overall, results supported the internal consistency and validity of the French versions of the SAS-A and SAI.

Technical quality of delivery care in private- and public-sector health facilities in Enugu and Lagos States, Nigeria.

PubMed

Hirose, Atsumi; Yisa, Ibrahim O; Aminu, Amina; Afolabi, Nathanael; Olasunmbo, Makinde; Oluka, George; Muhammad, Khalilu; Hussein, Julia

2018-06-01

Private-sector providers are increasingly being recognized as important contributors to the delivery of healthcare. Countries with high disease burdens and limited public-sector resources are considering using the private sector to achieve universal health coverage. However, evidence for the technical quality of private-sector care is lacking. This study assesses the technical quality of maternal healthcare during delivery in public- and private-sector facilities in resource-limited settings, from a systems and programmatic perspective. A summary index (the skilled attendance index, SAI), was used. Two-staged cluster sampling with stratification was used to select representative samples of case records in public- and private-sector facilities in Enugu and Lagos States, Nigeria. Information to assess criteria was extracted, and the SAI calculated. Linear regression models examined the relationship between SAI and the private and public sectors, controlling for confounders. The median SAI was 54.8% in Enugu and 85.7% in Lagos. The private for-profit sector's SAI was lower than and the private not-for-profit sector's SAI was higher than the public sector in Enugu [coefficient = -3.6 (P = 0.018) and 12.6 (P < 0.001), respectively]. In Lagos, the private for-profit sector's SAI was higher and the private not-for-profit sector's SAI was lower than the public sector [3.71 (P = 0.005) and -3.92 (P < 0.001)]. Results indicate that the technical quality of private for-profit providers' care was poorer than public providers where the public provision of care was weak, while private for-profit facilities provided better technical quality care than public facilities where the public sector was strong and there was a relatively strong regulatory body. Our findings raise important considerations relating to the quality of maternity care, the public-private mix and needs for regulation in global efforts to achieve universal healthcare.

Sleep disturbances and teacher ratings of school achievement and temperament in children.

PubMed

Bruni, Oliviero; Ferini-Strambi, Luigi; Russo, Paolo M; Antignani, Massimo; Innocenzi, Margherita; Ottaviano, Paola; Valente, Donatella; Ottaviano, Salvatore

2006-01-01

The current study examined the relationships between academic achievement, sleep, temperament and demographic-historical data in school-age children. Teachers were asked to fill out the teacher temperament questionnaire and a form for school achievement, while mothers filled out a demographic-historical form and the sleep disturbance scale for children (SDSC), a 26-item questionnaire that consisted of six factors: difficulty in initiating and maintaining sleep (DIMS), sleep breathing disorders (SBD), arousal disorders (DA), sleep-wake transition disorders (SWTD), disorders of excessive somnolence (DOES), sleep hyperhydrosis (SHY). From a sample of 380 school children, 264 (70%) were suitable for the analyses (141 M and 123 F aged 8-11 years, mean 9.6 years). A school achievement index (SAI) was derived, summing up four items (reading ability, reading comprehension, mathematics, executive ability) of the teacher form for school achievement. SAI mean for the total sample was 11.1 (SD=2.8). A significant gender difference was found: females have higher SAI than males. The analysis of the demographic-historical form showed that only two factors appeared to affect SAI score: enuresis and the low educational level of the mother. The pattern of correlations showed that (a) the SAI was negatively related to the SDSC total score, in particular to DIMS and DOES sub-factors, and (b) the SAI was significantly and positively correlated with the temperamental traits of task-orientation and personal-social flexibility. A multiple stepwise regression analysis showed that the temperamental traits task-orientation and personal-social flexibility are the most predictive factors for SAI while the mother's educational level and the SDSC total score, although they contributed significantly to the prediction of SAI, accounted for only a small portion of variance. Temperament and sleep are important factors influencing school achievement, and their assessment could help to identify

Radon constrains the transit time of springs water at the border between tabular Middle Atlas and the Sais Basin (Morocco)

NASA Astrophysics Data System (ADS)

Mayer, Adriano; Rouai, Mohammed; Saracco, Ginette; Dekayir, Abdelilak; Miche, Héléne

2010-05-01

The tabular Middle Atlas (TMA) is an important fractured karstic reservoir in northern Morocco constituted by Liassic limestones and dolomites with a nearly sub-horizontal attitude, overlying basalts, shales and evaporates of Triassic age, as well as Paleozoic anchi-metamorphic schists. The zone is characterised by relative abundant rainfall (700 mm/y) and the absence of a surface watershed, which lead to an important groundwater reservoir hosted in the karstic (k-) aquifer. TMA is bordered to the North by extensive graben-like, normal, northward, fault-systems, which burden the Karstic formations under Plio-quaternary sediments at the Sais Basin border. At this limit, several important springs of high water-quality occur at the northernmost outcropping Lias limestone, which is overlaid in some areas by quaternary travertines. Two of these springs in particular, Bittit and Ribaa springs, provide almost drinking water for the town of Meknes (0.7 Million inhabitants), for local population and agriculture. These springs experienced a significant drop in water flow-rate in the last decades. Although the main origin of this water is certainly the k-aquifer, the drop in water-table raises several questions regarding the modality of water transport (influence of fractured and karstic systems in particular) and the possible participations of other groundwater reservoirs, which may deteriorate the high water-quality. A recent study has been carried out to shed some light on these questions, by using geochemical methods (K, Mg, Na, Ca, Fe, Mn, Ba, Sr, As, Sb, Hg, HCO3, SO4, NO3, Cl, Br, delta18-O, deltaD, Rn, EC, O2, pH, Eh, Temp). Constraints on the groundwater flow-path have been obtained by using a radon- hydrochemical- isotopic characterisation of spring waters. Here we report the results of the first geochemical sample collection (November 09). Several springs in the TMA yield Mg-Ca HCO3 rich water equilibrated with limestone and dolomite, having a very similar Rn

Impact of water supply, domiciliary water reservoirs and sewage on faeco-orally transmitted parasitic diseases in children residing in poor areas in Juiz de Fora, Brazil.

PubMed

Teixeira, J C; Heller, L

2006-08-01

The objectives of this study were to characterize faeco-orally transmitted parasitic diseases and to identify the factors associated with these diseases, with emphasis on environmental factors, in children ranging from 1 up to 5 years old residing in substandard settlement areas. A population-based cross-sectional epidemiological design was used in a non-random selection of 29 out of the 78 substandard settlement areas in the municipality of Juiz de Fora, Brazil. A sample of 753 children were assessed from the target population consisting of all children of the appropriate age range residing in the selected areas. Data were collected by means of domiciliary interviews with their mothers or with the person responsible for them. The Hoffmann-Pons-Janer method was used in the parasitological examination of faeces. Binary logistic regression models were used to identify the factors associated with the diseases. A total of 319 sample children presented faeco-orally transmitted parasitic diseases. The factors associated with these parasitic diseases included the children's age, family income, number of dwellers in the domicile, consumption of water from shallow wells, consumption of water from natural sources, absence of covered domiciliary water reservoirs, and the presence of sewage flowing in the street.

Shock-absorbing insoles reduce the incidence of lower limb overuse injuries sustained during Royal Marine training.

PubMed

House, Carol; Reece, Allyson; Roiz de Sa, Dan

2013-06-01

This study was undertaken to determine whether the incidence of lower limb overuse injuries (LLOIs) sustained during Royal Marine training could be reduced by issuing the recruits with shock-absorbing insoles (SAIs) to wear in their military boots. This was a retrospective longitudinal trial conducted in two phases. Injury data from 1,416 recruits issued with standard Saran insoles and 1,338 recruits issued with SAI were compared. The recruits in the two groups were of similar height, body mass, and aerobic fitness and followed the same training course. The incidence of LLOI sustained by the recruits was lower (p < 0.05) in the SAI Group (19.0%) compared to the Saran Insole Group (31.7%). The incidences of lower limb stress fractures, tibial periostitis, tenosynovitis of foot, achilles tendonopathy, other tendonopathy and anterior knee pain were lower (p < 0.05) in the SAI Group. Tibial stress fracture incidence was lower (p < 0.05) in the SAI Group but metatarsal and femoral stress fracture incidences were the same for the two insole groups. Thus, issuing SAIs to military recruits undertaking a sustained, arduous physical training program with a high incidence of LLOI would provide a beneficial reduction in the incidence of LLOI. Reprint & Copyright © 2013 Association of Military Surgeons of the U.S.

New psychoactive substances (NPS) on cryptomarket fora: An exploratory study of characteristics of forum activity between NPS buyers and vendors.

PubMed

Van Hout, Marie Claire; Hearne, Evelyn

2017-02-01

The continual diversification of new psychoactive substances (NPS) circumventing legislation creates a public health and law enforcement challenge, and one particularly challenged by availability on Hidden Web cryptomarkets. This is the first study of its kind which aimed to explore and characterise cryptomarket forum members' views and perspectives on NPS vendors and products within the context of Hidden Web community dynamics. An internal site search was conducted on two cryptomarkets popular with NPS vendors and hosting fora; Alphabay and Valhalla, using the search terms of 40 popular NPS in the seven categories of stimulant/cathinone; GABA activating; hallucinogen, dissociative, cannabinoid, opioid and other/unspecified/uncategorised NPS. 852 identified threads relating to the discussion of these NPS were generated. Following exclusion of duplicates, 138 threads remained. The Empirical Phenomenological Psychological method of data analysis was applied. Four themes and 32 categories emerged. 120 vendors selling NPS were visible on Alphabay, and 21 on Valhalla. Themes were 'NPS Cryptomarkets and Crypto-community interest in NPS'; 'Motives for NPS use'; 'Indigenous Crypto Community Harm Reduction'; and 'Cryptomarket Characteristics underpinning NPS trafficking', with two higher levels of abstraction centring on 'NPS vendor reputation' and 'NPS transactioning for personal use'. NPS cryptomarket characteristics centred on generation of trust, honesty and excellent service. Users appeared well informed, with harm reduction and vendor information exchange central to NPS market dynamics. GABA activating substances appeared most popular in terms of buyer interest on cryptomarkets. Interest in sourcing 'old favorite' stimulant and dissociative NPS was evident, alongside the sequential and concurrent poly use of NPS, and use of NPS with illicit drugs such as MDMA. Continued monitoring of new trends in NPS within Surface Web and cryptomarkets are warranted. A particular

Quantifying Stream-Aquifer Exchanges Over Scales: the Concept of Nested Interfaces

NASA Astrophysics Data System (ADS)

Flipo, N.; Mouhri, A.; Labarthe, B.; Saleh, F. S.

2013-12-01

Recent developments in hydrological modelling are based on a view of the interface being a single continuum through which water flows. These coupled hydrological-hydrogeological models, emphasizing the importance of the stream-aquifer interface (SAI), are more and more used in hydrological sciences for pluri-disciplinary studies aiming at questioning environmental issues. This notion of a single continuum comes from the historical modelling of hydrosystems based on the hypothesis of a homogeneous media that led to the Darcy law. Nowadays, there is a need to first bridge the gap between hydrological and eco-hydrological views of the SAIs, and, second, to rationalize the modelling of SAI within a consistent framework that fully takes into account the multi-dimensionality of the SAIs. We first define the concept of nested SAIs as a key transitional component of continental hydrosystem. We then demonstrate the usefulness of the concept for the multi-dimensional study of the SAI, with a special emphasis on the stream network which is identified as the key component for scaling hydrological processes occurring at the interface. Finally we focus on SAI modelling at various scales with up-to-date methodologies and give some guidance for the multi-dimensional modelling of the interface using the innovative methodology MIM (Measurements-Interpolation-Modelling), which is graphically developed. MIM scales in space three pools of methods needed to fully understand SAIs. The outcome of MIM is the localization in space of the type of SAI that can be studied by a given approach. The efficiency of the method is illustrated from the local (approx. 1m) to the regional scale (> 10 000 km2) with two examples from the Paris basin (France). The first one consists in the implementation of a sampling system of stream-aquifer exchanges, which is coupled with local 2D thermo-hydro models and a pseudo 3D hydro(geo)logical model at the watershed scale (40 km2). The quantification of monthly

Associations between a neurophysiological marker of central cholinergic activity and cognitive functions in young and older adults

PubMed Central

2012-01-01

Background The deterioration of the central cholinergic system in aging is hypothesized to underlie declines in several cognitive domains, including memory and executive functions. However, there is surprisingly little direct evidence regarding acetylcholine’s specific role(s) in normal human cognitive aging. Methods We used short-latency afferent inhibition (SAI) with transcranial magnetic stimulation (TMS) as a putative marker of cholinergic activity in vivo in young (n = 24) and older adults (n = 31). Results We found a significant age difference in SAI, concordant with other evidence of cholinergic decline in normal aging. We also found clear age differences on several of the memory and one of the executive function measures. Individual differences in SAI levels predicted memory but not executive functions. Conclusion Individual differences in SAI levels were better predictors of memory than executive functions. We discuss cases in which the relations between SAI and cognition might be even stronger, and refer to other age-related biological changes that may interact with cholinergic activity in cognitive aging. PMID:22537877

Simultaneous stabilization of global temperature and precipitation through cocktail geoengineering

NASA Astrophysics Data System (ADS)

Cao, Long; Duan, Lei; Bala, Govindasamy; Caldeira, Ken

2017-07-01

Solar geoengineering has been proposed as a backup plan to offset some aspects of anthropogenic climate change if timely CO2 emission reductions fail to materialize. Modeling studies have shown that there are trade-offs between changes in temperature and hydrological cycle in response to solar geoengineering. Here we investigate the possibility of stabilizing both global mean temperature and precipitation simultaneously by combining two geoengineering approaches: stratospheric sulfate aerosol increase (SAI) that deflects sunlight to space and cirrus cloud thinning (CCT) that enables more longwave radiation to escape to space. Using the slab ocean configuration of National Center for Atmospheric Research Community Earth System Model, we simulate SAI by uniformly adding sulfate aerosol in the upper stratosphere and CCT by uniformly increasing cirrus cloud ice particle falling speed. Under an idealized warming scenario of abrupt quadrupling of atmospheric CO2, we show that by combining appropriate amounts of SAI and CCT geoengineering, global mean (or land mean) temperature and precipitation can be restored simultaneously to preindustrial levels. However, compared to SAI, cocktail geoengineering by mixing SAI and CCT does not markedly improve the overall similarity between geoengineered climate and preindustrial climate on regional scales. Some optimal spatially nonuniform mixture of SAI with CCT might have the potential to better mitigate climate change at both the global and regional scales.

Impact of idealized future stratospheric aerosol injection on the large-scale ocean and land carbon cycles

NASA Astrophysics Data System (ADS)

Tjiputra, J. F.; Grini, A.; Lee, H.

2016-01-01

Using an Earth system model, we simulate stratospheric aerosol injection (SAI) on top of the Representative Concentration Pathways 8.5 future scenario. Our idealized method prescribes aerosol concentration, linearly increasing from 2020 to 2100, and thereafter remaining constant until 2200. In the aggressive scenario, the model projects a cooling trend toward 2100 despite warming that persists in the high latitudes. Following SAI termination in 2100, a rapid global warming of 0.35 K yr-1 is simulated in the subsequent 10 years, and the global mean temperature returns to levels close to the reference state, though roughly 0.5 K cooler. In contrast to earlier findings, we show a weak response in the terrestrial carbon sink during SAI implementation in the 21st century, which we attribute to nitrogen limitation. The SAI increases the land carbon uptake in the temperate forest-, grassland-, and shrub-dominated regions. The resultant lower temperatures lead to a reduction in the heterotrophic respiration rate and increase soil carbon retention. Changes in precipitation patterns are key drivers for variability in vegetation carbon. Upon SAI termination, the level of vegetation carbon storage returns to the reference case, whereas the soil carbon remains high. The ocean absorbs nearly 10% more carbon in the geoengineered simulation than in the reference simulation, leading to a ˜15 ppm lower atmospheric CO2 concentration in 2100. The largest enhancement in uptake occurs in the North Atlantic. In both hemispheres' polar regions, SAI delays the sea ice melting and, consequently, export production remains low. In the deep water of North Atlantic, SAI-induced circulation changes accelerate the ocean acidification rate and broaden the affected area.

The Regularity of Sustained Firing Reveals Two Populations of Slowly Adapting Touch Receptors in Mouse Hairy Skin

PubMed Central

Wellnitz, Scott A.; Lesniak, Daine R.; Gerling, Gregory J.

2010-01-01

Touch is initiated by diverse somatosensory afferents that innervate the skin. The ability to manipulate and classify receptor subtypes is prerequisite for elucidating sensory mechanisms. Merkel cell–neurite complexes, which distinguish shapes and textures, are experimentally tractable mammalian touch receptors that mediate slowly adapting type I (SAI) responses. The assessment of SAI function in mutant mice has been hindered because previous studies did not distinguish SAI responses from slowly adapting type II (SAII) responses, which are thought to arise from different end organs, such as Ruffini endings. Thus we sought methods to discriminate these afferent types. We developed an epidermis-up ex vivo skin–nerve chamber to record action potentials from afferents while imaging Merkel cells in intact receptive fields. Using model-based cluster analysis, we found that two types of slowly adapting receptors were readily distinguished based on the regularity of touch-evoked firing patterns. We identified these clusters as SAI (coefficient of variation = 0.78 ± 0.09) and SAII responses (0.21 ± 0.09). The identity of SAI afferents was confirmed by recording from transgenic mice with green fluorescent protein–expressing Merkel cells. SAI receptive fields always contained fluorescent Merkel cells (n = 10), whereas SAII receptive fields lacked these cells (n = 5). Consistent with reports from other vertebrates, mouse SAI and SAII responses arise from afferents exhibiting similar conduction velocities, receptive field sizes, mechanical thresholds, and firing rates. These results demonstrate that mice, like other vertebrates, have two classes of slowly adapting light-touch receptors, identify a simple method to distinguish these populations, and extend the utility of skin–nerve recordings for genetic dissection of touch receptor mechanisms. PMID:20393068

A qualitative systematic review of the evidence base for non-cross-resistance between steroidal and non-steroidal aromatase inhibitors in metastatic breast cancer.

PubMed

Beresford, M; Tumur, I; Chakrabarti, J; Barden, J; Rao, N; Makris, A

2011-04-01

The most effective sequence of tamoxifen and both steroidal (SAIs) and non-steroidal aromatase inhibitors (NSAIs) has been extensively studied in the adjuvant setting. However, treatments for women who have failed initial aromatase inhibitor therapy in the metastatic setting have received relatively little attention. A systematic review was undertaken to assess the use of SAIs and NSAIs in metastatic breast cancer. Medline, Embase and the Cochrane library were searched using free text and MeSH terms. Studies assessing the cross-resistance, efficacy and safety of SAIs and NSAIs for postmenopausal women with advanced metastatic breast cancer confirmed by histology/cytology were included. Patients had progressed/relapsed from previous adjuvant, first- or second-line aromatase inhibitor treatment and had undergone treatment with at least two regimens consisting of aminoglutethimide, anastrozole, letrozole and/or exemestane. Nine studies reported results for patients treated with an SAI after treatment failure with an NSAI. For SAI after NSAI, clinical benefit was the most frequently reported outcome. The clinical benefit for exemestane (SAI) after any NSAI failure or before treatment ranged from 12% (complete response not recorded, partial response 2%, stable disease 10%) to 55% (complete response 6%, partial response 13%, stable disease 35%) Survival outcomes were infrequently reported; four studies reported disease progression. The time to progression ranged from 3.7 to 5.2 months. Only one study reported a median overall survival with exemestane at 15.2 months. Only one study reported information for an NSAI after SAI and an NSAI followed by another NSAI. This review suggests that switching from an NSAI to an SAI is a reasonable option. This would be particularly important for patients who would probably respond to further endocrine manoeuvres; strongly oestrogen receptor-positive disease, non-visceral disease, a good prior response or a long duration of response

Sudden Advanced Illness: An Emerging Concept Among Palliative Care and Surgical Critical Care Physicians.

PubMed

Barnett, Michael D; Williams, Beverly R; Tucker, Rodney O

2016-05-01

End-of-life discussions in critically-ill patients with acute surgical conditions may be rushed and occur earlier during hospitalization. This study explores the concept of sudden advanced illness (SAI) and its relevance to patients requiring Palliative and Surgical Critical Care. Semi-structured interviews were completed with 16 physicians, querying each about (1) definitional components, (2) illustrative cases, and (3) comfort with SAI. Analysis was done by grounded theory. SAI was characterized as unforeseen, emerging abruptly and producing devastating injury, often in healthy, younger patients. There is (1) prognostic uncertainty, (2) loss of capacity, and (3) unprepared surrogate decision-making. Cases are emotionally-charged and often personal. The emerging concept of SAI is important for understanding how Palliative Care can enhance care for this subset of patients. © The Author(s) 2014.

Revised stratigraphy of Area 123, Koobi Fora, Kenya, and new age estimates of its fossil mammals, including hominins.

PubMed

Gathogo, Patrick N; Brown, Francis H

2006-11-01

Recent geologic study shows that all hominins and nearly all other published mammalian fossils from Paleontological Collection Area 123, Koobi Fora, Kenya, derive from levels between the KBS Tuff (1.87+/-0.02 Ma) and the Lower Ileret Tuff (1.53+/-0.01 Ma). More specifically, the fossils derive from 53 m of section below the Lower Ileret Tuff, an interval in which beds vary markedly laterally, especially those units containing molluscs and algal stromatolites. The upper Burgi Member (approximately 2.00-1.87 Ma) crops out only in the southwestern part of Area 123. Adjacent Area 110 contains larger exposures of the member, and there the KBS Tuff is preserved as an airfall ash in lacustrine deposits and also as a fluvially redeposited ash. We observed no mammalian fossils in situ in this member in Area 123, but surface specimens have been documented in some monographic treatments. Fossil hominins from Area 123 were attributed to strata above the KBS Tuff in the 1970s, but later they were assigned to strata below the KBS Tuff (now called the upper Burgi Member). This study definitively places the Area 123 hominins in the KBS Member. Most of these hominins are between 1.60 and 1.65 myr in age, but the youngest may date to only 1.53 Ma, and the oldest, to 1.75 Ma. All are 0.15-0.30 myr younger than previously estimated. The new age estimates, in conjunction with published taxonomic attributions of fossils, suggest that at least two species of Homo coexisted in the region along with A. boisei until at least 1.65 Ma. Comparison of crania KNM-ER 1813 and KNM-ER 1470, which were believed to be of comparable age, is at the focus of the debate over whether Homo habilis sensu lato is in fact composed of two species: Homo habilis and Homo rudolfensis. These two crania are separated in time by approximately 0.25 myr, and therefore, arguments for their conspecificity no longer need to confront the issue of unusually high contemporaneous variation within a single species.

Frequencies of immune hypersensitivity reaction-associated HLA class I alleles in healthy South African Indian and mixed ancestry populations determined by a novel real-time PCR assay.

PubMed

Loubser, S; Paximadis, M; Gentle, N; Puren, A; Gray, C M; Tiemessen, C T

2014-10-01

We have determined the frequencies of human leucocyte antigen (HLA)-B*57:01, HLA-B*35:05, HLA-C*04 and HLA-C*08 in healthy individuals of South African Indian (SAI) ethnicity (n = 50) and South African mixed (SAM) ancestry (n = 50) using real-time allele-specific polymerase chain reaction (AS-PCR) assay. HLA-B*57:01 associates with immune hypersensitivity reaction (IHR) in individuals exposed to abacavir (ABC), while nevirapine (NVP) IHR associates with HLA-B*35:05, HLA-C*04 and HLA-C*08. Real-time AS-PCR assays typically use less DNA, are more cost-effective and rapid compared with conventional genotyping methods, such as sequence-based typing (SBT). The assay was developed using samples of known HLA class I genotype and subsequently applied to the SAI and SAM samples. HLA-B*57:01 was detected in SAM and SAI populations at frequencies of 8.0% and 12.0%, respectively, while HLA-B*35:05 was not found in SAI individuals, but was present in 6.0% of SAM individuals. HLA-C*04 was detected in 22.0% and 24.0% of SAM and SAI individuals, respectively, while 10.0% and 8.0% of SAM and SAI individuals, respectively, were HLA-C*08 positive. This study reports the development of a novel real-time AS-PCR assay to identify HLA class I alleles associated with ABC and NVP IHR and has established the frequencies of these alleles present in healthy SAI and SAM populations. Using South African demographic data, our hypothetical analysis suggests that a substantial number of individuals would benefit from the assay. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

An examination of sudden acceleration

DOT National Transportation Integrated Search

1989-01-01

This report describes the results of a study to identify and evaluate factors which could potentially cause or contribute to the occurrence of "Sudden Acceleration Incidents" (SAI). SAI are defined in this report as unintended, unexpected, high-power...

Effects of Cryoprotectants and Diluents on the Cryopreservation of Spermatozoa from Far Eastern Catfish, Silurus asotus

PubMed Central

Gil, Hyun Woo; Lee, Tae Ho; Park, In-Seok

2017-01-01

ABSTRACT The aim of this study was to compare the efficacy of cryopreservation methods for ex situ conservation of spermatozoa from far eastern catfish, Silurus asotus. The spermatozoa activity index (SAI) and hatching rates were higher in spermatozoa stored in Alserver’s solution than those of spermatozoa stored in glucose solution. The SAI and hatching rates in all experimental groups gradually decreased with increasing duration of storage. Additionally, the SAI and hatching rates gradually decreased with increasing thawing temperatures at all storage durations (P<0.05). Based on the SAI and hatching rates, our results suggest that the optimal cryopreservation conditions of catfish spermatozoa involve storage in Alserver’s solution with 15% ethylene glycol, and thawing at 25℃. Cryopreservation of spermatozoa is a useful and reliable technique for conserving gene resources and for artificial propagation of far eastern catfish. PMID:28484747

Nuclear Air Blast Effects.

DTIC Science & Technology

1982-06-01

AD-All? 43 SCIENCE APPLICATZOhu INC NCLAA VA F/6 19/4I NUICLEAR AIR BLAST IFPCTS(U) JUR " PRY UNCLASSIFID SAI-63-636-VA NLOOI I-C lit? I. 1174~ 132...SiCuftIt, CLASSFICA?1lOw OF fl.IS PAQ-C( fhbl Dal. Lnt.,.d, REPORT DOCUMENTATION4 PAGE apoI ct~ NUCLEAR AIR BLAST EFFECTS FINAL REPORT SAI-83-836-WA...TUCSON a WASHINGTON NUCLEAR AIR BLAST EFFECTS FINAL REPORT SAI-83-836-WA Submitted to: Laboratory for Computational Physics Naval Research Laboratory

Detecting the global and regional effects of sulphate aerosol geoengineering

NASA Astrophysics Data System (ADS)

Lo, Eunice; Charlton-Perez, Andrew; Highwood, Ellie

2017-04-01

Climate warming is unequivocal. In addition to carbon dioxide emission mitigation, some geoengineering ideas have been proposed to reduce future surface temperature rise. One of these proposals involves injecting sulphate aerosols into the stratosphere to increase the planet's albedo. Monitoring the effectiveness of sulphate aerosol injection (SAI) would require us to be able to distinguish and detect its cooling effect from the climate system's internal variability and other externally forced temperature changes. This research uses optimal fingerprinting techniques together with simulations from the GeoMIP data base to estimate the number of years of observations that would be needed to detect SAI's cooling signal in near-surface air temperature, should 5 Tg of sulphur dioxide be injected into the stratosphere per year on top of RCP4.5 from 2020-2070. The first part of the research compares the application of two detection methods that have different null hypotheses to SAI detection in global mean near-surface temperature. The first method assumes climate noise to be dominated by unforced climate variability and attempts to detect the SAI cooling signal and greenhouse gas driven warming signal in the "observations" simultaneously against this noise. The second method considers greenhouse gas driven warming to be a non-stationary background climate and attempts to detect the net cooling effect of SAI against this background. Results from this part of the research show that the conventional multi-variate detection method that has been extensively used to attribute climate warming to anthropogenic sources could also be applied for geoengineering detection. The second part of the research investigates detection of geoengineering effects on the regional scale. The globe is divided into various sub-continental scale regions and the cooling effect of SAI is looked for in the temperature time series in each of these regions using total least squares multi

A comparison of blind nasotracheal and succinylcholine-assisted intubation in the poisoned patient.

PubMed

Dronen, S C; Merigian, K S; Hedges, J R; Hoekstra, J W; Borron, S W

1987-06-01

In the patient obtunded by drug intoxication, the optimal method of airway protection prior to gastric emptying is not clear. We report a prospective randomized trial of two methods of intubation in this patient population. Fifty-two overdose patients with Glascow Coma Scale scores of 12 or less were intubated either orotracheally after succinylcholine administration or nasotracheally. Success rate, time to intubate, difficulty, and complications of intubation were compared for the two groups. We found a success rate of 100% (23 of 23) for succinylcholine assisted intubation (SAI) versus 65% (19 of 29) success with blind nasotracheal intubation (BNI). Mean time to intubate was 64 seconds and 276 seconds in the SAI and BNI groups, respectively. Eighty-six percent (19 of 22) of patients were intubated successfully in less than 120 seconds in the SAI group versus 37% (10 of 27) in the BNI group (P less than .005). In the SAI group, the mean number of attempts was 1.3 per patient, (range, one to three) with 96% (22 of 23) having two or fewer attempts. No complications were identified. In the BNI group, the mean number of attempts was 3.7 per patient, (range, one to 13) with 45% (13 of 29) having two or fewer attempts (P less than .005). Sixty-nine percent of the BNI group experienced epistaxis, 17% had vomiting, and 10% aspirated. We conclude that SAI is a safe and effective method of airway protection in the obtunded poisoned patient. Complications and difficulty in intubation were significantly less with SAI than with blind nasotracheal intubation.

Attention modulates specific motor cortical circuits recruited by transcranial magnetic stimulation.

PubMed

Mirdamadi, J L; Suzuki, L Y; Meehan, S K

2017-09-17

Skilled performance and acquisition is dependent upon afferent input to motor cortex. The present study used short-latency afferent inhibition (SAI) to probe how manipulation of sensory afference by attention affects different circuits projecting to pyramidal tract neurons in motor cortex. SAI was assessed in the first dorsal interosseous muscle while participants performed a low or high attention-demanding visual detection task. SAI was evoked by preceding a suprathreshold transcranial magnetic stimulus with electrical stimulation of the median nerve at the wrist. To isolate different afferent intracortical circuits in motor cortex SAI was evoked using either posterior-anterior (PA) or anterior-posterior (PA) monophasic current. In an independent sample, somatosensory processing during the same attention-demanding visual detection tasks was assessed using somatosensory-evoked potentials (SEP) elicited by median nerve stimulation. SAI elicited by AP TMS was reduced under high compared to low visual attention demands. SAI elicited by PA TMS was not affected by visual attention demands. SEPs revealed that the high visual attention load reduced the fronto-central P20-N30 but not the contralateral parietal N20-P25 SEP component. P20-N30 reduction confirmed that the visual attention task altered sensory afference. The current results offer further support that PA and AP TMS recruit different neuronal circuits. AP circuits may be one substrate by which cognitive strategies shape sensorimotor processing during skilled movement by altering sensory processing in premotor areas. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study.

PubMed

Nardone, Raffaele; Bergmann, Jürgen; De Blasi, Pierpaolo; Kronbichler, Martin; Kraus, Jörg; Caleri, Francesca; Tezzon, Frediano; Ladurner, Gunther; Golaszewski, Stefan

2010-03-01

The specific neurochemical substrate underlying the amnesia in patients with Wernicke-Korsakoff syndrome (WKS) is still poorly defined. Memory impairment has been linked to dysfunction of neurons in the cholinergic system. A transcranial magnetic stimulation (TMS) protocol, the short latency afferent inhibition (SAI), may give direct information about the function of some cholinergic pathways in the human motor cortex. In the present study, we measured SAI in eight alcoholics with WKS and compared the data with those from a group of age-matched healthy individuals; furthermore, we correlated the individual SAI values of the WKS patients with memory and other cognitive functions. Mean SAI was significantly reduced in WKS patients when compared with the controls. SAI was increased after administration of a single dose of donezepil in a subgroup of four patients. The low score obtained in the Rey Complex Figure delayed recall test, the Digit Span subtest of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) and the Corsi's Block Span subtest of the WAIS-R documented a severe impairment in the anterograde memory and short-term memory. None of the correlations between SAI values and these neuropsychological tests reached significance. We provide physiological evidence of cholinergic involvement in WKS. However, this putative marker of central cholinergic activity did not significantly correlate with the memory deficit in our patients. These findings suggest that the cholinergic dysfunction does not account for the memory disorder and that damage to the cholinergic system is not sufficient to cause a persisting amnesic syndrome in WKS.

76 FR 5858 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... Colombia; nationality Lebanon; alt. nationality Colombia; Cedula No. 84075050 (Colombia); Passport RL 0235074 (Lebanon); alt. Passport P013331 (Colombia) (individual) [SDNTK] 2. JOUMAA, Akram Saied (a.k.a...; Passport 11869936 (Venezuela); RUC 3-NT-1-6255 (Panama) (individual) [SDNTK] 3. JOUMAA, Anwar Saied (a.k.a...

The Relationship between Student Anti-Intellectualism and Proneness to Boredom in a Sample of College Students

ERIC Educational Resources Information Center

Laverghetta, Antonio

2015-01-01

College student anti-intellectualism is defined as a general disdain of intellectual and academic endeavors. Eigenberger and Sealander (2001), using the student anti-intellectualism scale (SAIS), reported that SAIS scores were negatively correlated with openness to experience and elaborative/deep cognitive processing. Proneness to boredom,…

Impact of Idealized Stratospheric Aerosol Injection on the Future Ocean and Land Carbon Cycles

NASA Astrophysics Data System (ADS)

Tjiputra, J.; Lauvset, S.

2017-12-01

Using a state-of-the-art Earth system model, we simulate stratospheric aerosol injection (SAI) on top of the Representative Concentration Pathways 8.5 future scenario. Our idealized method prescribes aerosol concentration, linearly increasing from 2020 to 2100, and thereafter remaining constant until 2200. In one of the scenarios, the model able to project future warming below 2 degree toward 2100, despite greatier warming persists in the high latitudes. When SAI is terminated in 2100, a rapid global warming of 0.35 K yr-1 (as compared to 0.05 K yr-1 under RCP8.5) is simulated in the subsequent 10 years, and the global mean temperature rapidly returns to levels close to the reference state. In contrast to earlier findings, we show a weak response in the terrestrial carbon sink during SAI implementation in the 21st century, which we attribute to nitrogen limitation. The SAI increases the land carbon uptake in the temperate forest-, grassland-, and shrub-dominated regions. The resultant lower temperatures lead to a reduction in the heterotrophic respiration rate and increase soil carbon retention. Changes in precipitation patterns are key drivers for variability in vegetation carbon. Upon SAI termination, the level of vegetation carbon storage returns to the reference case, whereas the soil carbon remains high. The ocean absorbs nearly 10% more carbon in the geoengineered simulation than in the reference simulation, leading to a ˜15 ppm lower atmospheric CO2 concentration in 2100. The largest enhancement in uptake occurs in the North Atlantic. In both hemispheres' polar regions, SAI delays the sea ice melting and, consequently, export production remains low. Despite inducing little impact on surface acidification, in the deep water of North Atlantic, SAI-induced circulation changes accelerate the ocean acidification rate and broaden the affected area. Since the deep ocean provides vital ecosystem function and services, e.g., fish stocks, this accelerated changes

Metrics, Dollars, and Systems Change: Learning from Washington State's Student Achievement Initiative to Design Effective Postsecondary Performance Funding Policies. A State Policy Brief

ERIC Educational Resources Information Center

Jenkins, Davis; Shulock, Nancy

2013-01-01

The Student Achievement Initiative (SAI), adopted by the Washington State Board for Community and Technical Colleges in 2007, is one of a growing number of performance funding programs that have been dubbed "performance funding 2.0." Unlike previous performance funding models, the SAI rewards colleges for students' intermediate…

Measuring Successful Aging in Southern Black Older Adults

ERIC Educational Resources Information Center

Troutman, Meredith; Nies, Mary A.; Bentley, Monica

2011-01-01

With the growing size of the population of aging Black individuals, it is important to understand successful aging in this group. This study, therefore, piloted the Successful Aging Inventory (SAI) with a convenience sample of Black older adults. Participants completed a demographic form, the SAI, Purpose in Life Test, Life Satisfaction…

Enacting Effective Climate Policy Advice: Institutional Strategies to Foster Saliency, Credibility and Legitimacy

ERIC Educational Resources Information Center

Bauer, Anja; Pregernig, Michael; Reinecke, Sabine

2016-01-01

This article asks how scientific advisory institutions (SAIs) in climate policy strive towards effectiveness. Our analysis is grounded on the assumption that effectiveness is not passively experienced but is deliberately enacted by SAIs. We draw on a widely used set of criteria, namely saliency, credibility and legitimacy (SCL). Based on an…

On the spatial distribution of decameter‒scale subauroral ionospheric irregularities observed by SuperDARN radars

NASA Astrophysics Data System (ADS)

Larquier, S.; Ponomarenko, P.; Ribeiro, A. J.; Ruohoniemi, J. M.; Baker, J. B. H.; Sterne, K. T.; Lester, M.

2013-08-01

The midlatitude Super Dual Auroral Radar Network (SuperDARN) radars regularly observe nighttime low‒velocity Sub‒Auroral Ionospheric Scatter (SAIS) from decameter‒scale ionospheric density irregularities during quiet geomagnetic conditions. To establish the origin of the density irregularities responsible for low‒velocity SAIS, it is necessary to distinguish between the effects of high frequency (HF) propagation and irregularity occurrence itself on the observed backscatter distribution. We compare range, azimuth, and elevation data from the Blackstone SuperDARN radar with modeling results from ray tracing coupled with the International Reference Ionosphere assuming a uniform irregularity distribution. The observed and modeled distributions are shown to be very similar. The spatial distribution of backscattering is consistent with the requirement that HF rays propagate nearly perpendicular to the geomagnetic field lines (aspect angle ≤1°). For the first time, the irregularities responsible for low‒velocity SAIS are determined to extend between 200 and 300 km altitude, validating previous assumptions that low‒velocity SAIS is an F‒region phenomenon. We find that the limited spatial extent of this category of ionospheric backscatter within SuperDARN radars' fields‒of‒view is a consequence of HF propagation effects and the finite vertical extent of the scattering irregularities. We conclude that the density irregularities responsible for low‒velocity SAIS are widely distributed horizontally within the midlatitude ionosphere but are confined to the bottom‒side F‒region.

Student Attitude Inventory - 1971.

ERIC Educational Resources Information Center

Gillmore, Gerald M.; Aleamoni, Lawrence M.

This 42-item Student Attitude Inventory (SAI) was administered to entering college freshmen at the University of Illinois (see TM 001 015). The SAI items are divided into nine categories on the basis of content as follows: voting behavior, drug usage, financial, Viet Nam war, education, religious behavior, pollution, housing, and alienation. A…

Fiber-Reinforced Origamic Robotic Actuator.

PubMed

Yi, Juan; Chen, Xiaojiao; Song, Chaoyang; Wang, Zheng

2018-02-01

A novel pneumatic soft linear actuator Fiber-reinforced Origamic Robotic Actuator (FORA) is proposed with significant improvements on the popular McKibben-type actuators, offering nearly doubled motion range, substantially improved force profile, and significantly lower actuation pressure. The desirable feature set is made possible by a novel soft origamic chamber that expands radially while contracts axially when pressurized. Combining this new origamic chamber with a reinforcing fiber mesh, FORA generates very high traction force (over 150N) and very large contractile motion (over 50%) at very low input pressure (100 kPa). We developed quasi-static analytical models both to characterize the motion and forces and as guidelines for actuator design. Fabrication of FORA mostly involves consumer-grade three-dimensional (3D) printing. We provide a detailed list of materials and dimensions. Fabricated FORAs were tested on a dedicated platform against commercially available pneumatic artificial muscles from Shadow and Festo to showcase its superior performances and validate the analytical models with very good agreements. Finally, a robotic joint was developed driven by two antagonistic FORAs, to showcase the benefits of the performance improvements. With its simple structure, fully characterized mechanism, easy fabrication procedure, and highly desirable performance, FORA could be easily customized to application requirements and fabricated by anyone with access to a 3D printer. This will pave the way to the wider adaptation and application of soft robotic systems.

Characterization of Cortisol Secretion Rate in Secondary Adrenal Insufficiency

PubMed Central

Qiao, Zhi George; Bouchonville, Matthew; Qualls, Clifford R.; Schrader, Ronald M.; Urban, Frank K.

2017-01-01

Context: In secondary adrenal insufficiency (SAI), chronic deficiency of adrenocorticotropin (ACTH) is believed to result in secondary changes in adrenocortical function, causing an altered dose-response relationship between ACTH concentration and cortisol secretion rate (CSR). Objective: We sought to characterize maximal cortisol secretion rate (CSRmax) and free cortisol half-life in patients with SAI, compare results with those of age-matched healthy controls, and examine the influence of predictor variables on ACTH-stimulated cortisol concentrations. Design: CSRmax was estimated from ACTH1-24 (250 μg)–stimulated cortisol time-concentration data. Estimates for CSRmax and free cortisol half-life were obtained for both dexamethasone (DEX) and placebo pretreatment conditions for all subjects. Setting: Single academic medical center. Patients: Patients with SAI (n = 10) compared with age-matched healthy controls (n = 21). Interventions: The order of DEX vs placebo pretreatment was randomized and double-blind. Cortisol concentrations were obtained at baseline and at intervals for 120 minutes after ACTH1-24. Main Outcome Measures: CSRmax and free cortisol half-life were obtained by numerical modeling analysis. Predictors of stimulated cortisol concentrations were evaluated using a multivariate model. Results: CSRmax was significantly (P < 0.001) reduced in patients with SAI compared with controls for both placebo (0.17 ± 0.09 vs 0.46 ± 0.14 nM/s) and DEX (0.18 ± 0.13 vs 0.43 ± 0.13 nM/s) conditions. Significant predictors of ACTH1-24–stimulated total cortisol concentrations included CSRmax, free cortisol half-life, and baseline total cortisol, corticosteroid-binding globulin, and albumin concentrations (all P < 0.05). Conclusions: Our finding of significantly decreased CSRmax confirms that SAI is associated with alterations in the CSR-ACTH dose-response curve. Decreased CSRmax contributes importantly to the laboratory diagnosis of SAI. PMID:29264545

Characterization of Cortisol Secretion Rate in Secondary Adrenal Insufficiency.

PubMed

Dorin, Richard I; Qiao, Zhi George; Bouchonville, Matthew; Qualls, Clifford R; Schrader, Ronald M; Urban, Frank K

2017-07-01

In secondary adrenal insufficiency (SAI), chronic deficiency of adrenocorticotropin (ACTH) is believed to result in secondary changes in adrenocortical function, causing an altered dose-response relationship between ACTH concentration and cortisol secretion rate (CSR). We sought to characterize maximal cortisol secretion rate (CSR max ) and free cortisol half-life in patients with SAI, compare results with those of age-matched healthy controls, and examine the influence of predictor variables on ACTH-stimulated cortisol concentrations. CSR max was estimated from ACTH 1-24 (250 μg) - stimulated cortisol time-concentration data. Estimates for CSR max and free cortisol half-life were obtained for both dexamethasone (DEX) and placebo pretreatment conditions for all subjects. Single academic medical center. Patients with SAI (n = 10) compared with age-matched healthy controls (n = 21). The order of DEX vs placebo pretreatment was randomized and double-blind. Cortisol concentrations were obtained at baseline and at intervals for 120 minutes after ACTH 1-24 . CSR max and free cortisol half-life were obtained by numerical modeling analysis. Predictors of stimulated cortisol concentrations were evaluated using a multivariate model. CSR max was significantly ( P < 0.001) reduced in patients with SAI compared with controls for both placebo (0.17 ± 0.09 vs 0.46 ± 0.14 nM/s) and DEX (0.18 ± 0.13 vs 0.43 ± 0.13 nM/s) conditions. Significant predictors of ACTH 1-24- stimulated total cortisol concentrations included CSR max , free cortisol half-life, and baseline total cortisol, corticosteroid-binding globulin, and albumin concentrations (all P < 0.05). Our finding of significantly decreased CSR max confirms that SAI is associated with alterations in the CSR-ACTH dose-response curve. Decreased CSR max contributes importantly to the laboratory diagnosis of SAI.

Automated Critical Test Findings Identification and Online Notification System Using Artificial Intelligence in Imaging.

PubMed

Prevedello, Luciano M; Erdal, Barbaros S; Ryu, John L; Little, Kevin J; Demirer, Mutlu; Qian, Songyue; White, Richard D

2017-12-01

Purpose To evaluate the performance of an artificial intelligence (AI) tool using a deep learning algorithm for detecting hemorrhage, mass effect, or hydrocephalus (HMH) at non-contrast material-enhanced head computed tomographic (CT) examinations and to determine algorithm performance for detection of suspected acute infarct (SAI). Materials and Methods This HIPAA-compliant retrospective study was completed after institutional review board approval. A training and validation dataset of noncontrast-enhanced head CT examinations that comprised 100 examinations of HMH, 22 of SAI, and 124 of noncritical findings was obtained resulting in 2583 representative images. Examinations were processed by using a convolutional neural network (deep learning) using two different window and level configurations (brain window and stroke window). AI algorithm performance was tested on a separate dataset containing 50 examinations with HMH findings, 15 with SAI findings, and 35 with noncritical findings. Results Final algorithm performance for HMH showed 90% (45 of 50) sensitivity (95% confidence interval [CI]: 78%, 97%) and 85% (68 of 80) specificity (95% CI: 76%, 92%), with area under the receiver operating characteristic curve (AUC) of 0.91 with the brain window. For SAI, the best performance was achieved with the stroke window showing 62% (13 of 21) sensitivity (95% CI: 38%, 82%) and 96% (27 of 28) specificity (95% CI: 82%, 100%), with AUC of 0.81. Conclusion AI using deep learning demonstrates promise for detecting critical findings at noncontrast-enhanced head CT. A dedicated algorithm was required to detect SAI. Detection of SAI showed lower sensitivity in comparison to detection of HMH, but showed reasonable performance. Findings support further investigation of the algorithm in a controlled and prospective clinical setting to determine whether it can independently screen noncontrast-enhanced head CT examinations and notify the interpreting radiologist of critical findings. �

Acute effects of muscle vibration on sensorimotor integration.

PubMed

Lapole, Thomas; Tindel, Jérémy

2015-02-05

Projections from the somesthetic cortex are believed to be involved in the modulation of motor cortical excitability by muscle vibration. The aim of the present pilot study was to analyse the effects of a vibration intervention on short-latency afferent inhibition (SAI), long-latency afferent inhibition (LAI), and afferent facilitation (AF), three intracortical mechanisms reflecting sensorimotor integration. Abductor pollicis brevis (APB) SAI, AF and LAI were investigated on 10 subjects by conditioning test transcranial magnetic stimulation pulses with median nerve electrical stimulation at inter-stimuli intervals in the range 15-25 ms, 25-60 ms, and 100-200 ms, respectively. Test motor evoked potentials (MEPs) were compared to unconditioned MEPs. Measurements were performed before and just after 15 min of vibration applied to the muscle belly of APB at a frequency of 80 Hz. SAI and LAI responses were significantly reduced compared to unconditioned test MEPs (P=0.039 and P<0.001, respectively). AF MEP amplitude was greater than SAI and LAI one (P=0.009 and P=0.004, respectively), but not different from test MEP (P=0.511). There was no significant main effect of vibration (P=0.905). However, 4 subjects were clearly identified as responders. Their mean vibration-induced increase was 324 ± 195% in APB SAI MEP amplitude, and 158 ± 53% and 319 ± 80% in AF and LAI, respectively. Significant differences in SAI, AF and LAI vibration-induced changes were found for responders when compared to non-responders (P=0.019, P=0.038, and P=0.01, respectively). A single session of APB vibration may increase sensorimotor integration, via decreased inhibition and increased facilitation. However, such results were not observed for all subjects, suggesting that other factors (such as attention to the sensory inputs) may have played a role. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Efficacy of exemestane after nonsteroidal aromatase inhibitor use in metastatic breast cancer patients.

PubMed

Kim, Sun Hye; Park, In Hae; Lee, Hyewon; Lee, Keun Seok; Nam, Byung-Ho; Ro, Jungsil

2012-01-01

Previous studies have suggested a lack of complete cross-resistance between steroidal (exemestane) and non-steroidal aromatase inhibitors (nSAI). Eighty-eight metastatic breast cancer (MBC) patients who received 25 mg of exemestane orally once a day at the National Cancer Center, Korea, between 2003 and 2009, were reviewed retrospectively. All patients had received nSAI for metastatic disease prior to exemestane therapy. The median age was 52 years (range, 33-79), and 13 (14.8%) patients were premenopausal who concomitantly received GnRH agonist. Exemestane was given as a second- (80.7%) or third-line (19.3%) hormone therapy. The clinical benefit (CB) rate (complete response + partial response + stable disease ≥ 24 weeks) was 30.7%, with a median CB duration of 10.0 months (range, 6.3-78.7). The median progression-free survival (PFS) was 3.0 months (95% confidence interval [CI], 1.99-4.01) and the overall survival (OS) 21.5 months (95% CI, 17.96-25.04), with a median follow-up of 50.3 months. Patients who achieved CB had longer OS than those patients who did not (29.6 vs 17.9 months; P = 0.002). On univariate analysis of predictive factors, patients who had achieved CB from previous nSAI tended to show lower CB rate (24.6% vs 44.4%, respectively; P = 0.063) and shorter PFS (2.8 vs 4.8 months, respectively; p = 0.233) than patients who had not. Achieving CB from previous nSAI became independent predictive factor for CBR to exemestane on multivariable analysis (Odds ratio = 2.852, P = 0.040). Exemestane after nSAI failure was effective in prolonging CB duration. The drug's efficacy seemed to be inferior in patients who had benefit from previous nSAI use.

School Anxiety Inventory: Reliability and Validity Evidence in a Sample of Slovenian Adolescents

ERIC Educational Resources Information Center

Levpušcek, Melita Puklek; Inglés, Candido J.; Marzo, Juan C.; García-Fernández, Jose M.

2015-01-01

The purpose of this study was to examine the reliability and validity of the School Anxiety Inventory (SAI) using a sample of 646 Slovenian adolescents (48% boys), ranging in age from 12 to 19 years. Single confirmatory factor analyses replicated the correlated four-factor structure of scores on the SAI for anxiety-provoking school situations…

Formestane, a steroidal aromatase inhibitor after failure of non-steroidal aromatase inhibitors (anastrozole and letrozole): is a clinical benefit still achievable?

PubMed

Carlini, P; Frassoldati, A; De Marco, S; Casali, A; Ruggeri, E M; Nardi, M; Papaldo, P; Fabi, A; Paoloni, F; Cognetti, F

2001-11-01

There are few clinical data on the sequential use of aromatase inhibitors (AI). This paper focuses on the relevance of clinical benefit CB (CR + PR + SD > or = 6 months) in postmenopausal metastatic breast cancer (MBC) patients treated with the steroidal aromatase inhibitor (SAI) formestane (FOR). who had already received non-steroidal aromatase inhibitor (nSAI): letrozole (LTZ) or anastrozole (ANZ). Twenty postmenopausal women with MBC were analysed in this retrospective two-centre study with the sequence nSAI-FOR. When receiving ANZ, 1 of 11 achieved a complete response and 9 of 11 a stable disease > or = 6 months, and receiving LTZ 1 of 9 achieved a partial response and 4 of 9 a stable disease > or = 6 months. The analysis of the entire population treated with FOR showed an overall CB of 55% (11 of 20) with a median duration of 15 months and median time to progression (TTP) of 6 months. Formestane 250 mg once bi-weekly seems to be an attractive alternative third-line hormonal therapy for the treatment of patients with MBC, previously treated with nSAI.

The Strengths Assessment Inventory: Reliability of a New Measure of Psychosocial Strengths for Youth

ERIC Educational Resources Information Center

Brazeau, James N.; Teatero, Missy L.; Rawana, Edward P.; Brownlee, Keith; Blanchette, Loretta R.

2012-01-01

A new measure, the Strengths Assessment Inventory-Youth self-report (SAI-Y), was recently developed to assess the strengths of children and adolescents between the ages of 10 and 18 years. The SAI-Y differs from similar measures in that it provides a comprehensive assessment of strengths that are intrinsic to the individual as well as strengths…

Selfie Aging Index: An Index for the Self-assessment of Healthy and Active Aging.

PubMed

Gonçalves, Judite; Gomes, Maria Isabel; Fonseca, Miguel; Teodoro, Tomás; Barros, Pedro Pita; Botelho, Maria-Amália

2017-01-01

Governments across Europe want to promote healthy and active aging, as a matter of both public health and economic sustainability. Designing policies focused on the most vulnerable groups requires information at the individual level. However, a measure of healthy and active aging at the individual level does not yet exist. This paper develops the Selfie Aging Index (SAI), an individual-level index of healthy and active aging. The SAI is developed thinking about a tool that would allow each person to take a selfie of her aging status. Therefore, it is based entirely on self-assessed indicators. This paper also illustrates how the SAI may look like in practice. The SAI is based on the Biopsychosocial Assessment Model (MAB), a tool for the multidimensional assessment of older adults along three domains: biological, psychological, and social. Indicators are selected and their weights determined based on an ordered probit model that relates the MAB indicators to self-assessed health, which proxies healthy and active aging. The ordered probit model predicts the SAI based on the estimated parameters. Finally, predictions are rescaled to the 0-1 interval. Data for the SAI development come from the Study of the Aging Profiles of the Portuguese Population and the Survey of Health, Aging, and Retirement in Europe. The selected indicators are BMI, having difficulties moving around indoors and performing the activities of daily living, feeling depressed, feeling nervous, lacking energy, time awareness score, marital status, having someone to confide in, education, type of job, exercise, and smoking status. The model also determines their weights. Results shed light on various factors that contribute significantly to healthy and active aging. Two examples are mental health and exercise, which deserve more attention from individuals themselves, health-care professionals, and public health policy. The SAI has the potential to put the individual at the center of the healthy and

Suicidality and its association with insight and neurocognition in taiwanese patients with bipolar I disorder in remission.

PubMed

Yen, Cheng-Fang; Cheng, Chung-Ping; Ko, Chih-Hung; Yen, Ju-Yu; Huang, Chi-Fen; Chen, Cheng-Sheng

2008-06-01

The aims of this study were to examine the relationships between suicidality, insight, and neurocognition in patients with bipolar I disorder who were in a remitted state. Using the Violence and Suicide Assessment Scale, we evaluated 96 patients with bipolar I disorder in remission to determine their suicidal ideations and attempts over the previous year. We also evaluated their level of insight by using the Schedule of Assessment of Insight (SAI) and its expanded version (SAI-E), as well as their neurocognitive function by a series of neurocognitive function tests. Insight and neurocognitive functions of bipolar subjects who had and who had no suicidal ideations or attempts over the previous year were compared. The results indicated that the remitted bipolar subjects who had suicidal ideations or attempts over the previous year had higher insight scores on all 3 SAI dimensions and on the SAI-E compared with those who had no suicidal ideations or attempts. However, no difference in any neurocognitive function was found between the 2 groups of remitted bipolar subjects. The results of this study suggest clinicians need to be particularly alert to the potential for suicide in bipolar patients with a high level of insight.

The Occurrence of Small-scale Irregularities in the Mid-latitude Ionosphere from SuperDARN HF Radar Observations

NASA Astrophysics Data System (ADS)

Ruohoniemi, J. M.; Baker, J. B.; Maimaiti, M.; Oksavik, K.; Erickson, P. J.; Scales, W.; Eltrass, A.

2017-12-01

The mid-latitude radars of the SuperDARN network routinely observe backscatter from nighttime decameter-scale F region irregularities at latitudes well equatorward of the auroral boundary. This Sub-Auroral Ionospheric Scatter (SAIS) is strongly distinguished from auroral and SAPS backscatter by low Doppler velocities ( tens m/s) and stable, long-lived ( hours) occurrence in discrete events that are extended in both latitude and longitude. Statistical and event studies of SAIS with the SuperDARN radars indicate that the subauroral F region ionosphere is replete with irregularities during events, at least poleward of the 50° Λ horizon of the North American mid-latitude radars, and that radar observation of SAIS backscatter is then primarily limited by the magnetic aspect condition. Joint experiments with incoherent scatter radar have furnished sets of plasma measurements suitable for testing theories of plasma instability. Modeling work stimulated by the observations has explored the temperature-gradient instability (TGI) and the gradient drift instability (GDI) as possible sources of the irregularities. In this talk we review the findings on the occurrence of the SAIS category of mid-latitude F region irregularities, summarize the results of the modeling work, and discuss future research directions.

Impairment of sensory-motor plasticity in mild Alzheimer's disease.

PubMed

Terranova, Carmen; Carmen, Terranova; SantAngelo, Antonino; Antonino, Sant'Angelo; Morgante, Francesca; Francesca, Morgante; Rizzo, Vincenzo; Vincenzo, Rizzo; Allegra, Roberta; Roberta, Allegra; Arena, Maria Grazia; Grazia, Arena Maria; Ricciardi, Lucia; Lucia, Ricciardi; Ghilardi, Marie Felice; Felice, Ghilardi Maria; Girlanda, Paolo; Paolo, Girlanda; Quartarone, Angelo; Angelo, Quartarone

2013-01-01

Primary motor cortex (M1) is relatively spared in the early stages of Alzheimer's disease (AD). Aim of the present study was to investigate whether abnormal M1 synaptic plasticity is present at an early stage of AD. We employed an electrophysiological protocol, named rapid paired associative stimulation (rPAS), involving repetitive transcranial magnetic stimulation (rTMS) paired with electrical stimulation of the contralateral median nerve, that modifies corticospinal excitability and short latency afferent inhibition (SAI). We studied 10 patients with a diagnosis of probable mild AD according to the Mini Mental State Examination score (minimum 21) and 14 age-matched control subjects. Motor evoked potentials (MEP) amplitudes and short-afferent inhibition (SAI) were measured at baseline before and for up to 60 min after 5Hz-rPAS in abductor pollicis brevis (APB). rPAS consisted of 600 pairs of transcranial magnetic stimuli, at a rate of 5 Hz for 2 min, coupled with electrical median nerve stimulation preceding TMS over the contralateral M1 at an inter-stimulus interval of 25 ms. Baseline SAI was significantly reduced in AD patients. In the control subjects rPAS induced a significant increase in MEP amplitudes and a decrease of SAI in the APB muscle persistently for up to 1 h. Conversely 5Hz-rPAS did not induce any significant changes in MEP amplitudes and SAI in mild AD patients. Sensory-motor plasticity is impaired in the motor cortex of AD at an early stage of the disease. Copyright © 2013 Elsevier Inc. All rights reserved.

Raman Investigation of Structural Photoinduced Irreversible Changes of Ga(10)Ge(25)S(65) Chalcogenide Glasses

DTIC Science & Technology

2001-06-01

Brazil cDepto de Quimica - Universidade Federal de Juiz de Fora, Juiz de Fora, MG- Brazil dEscola de Engenharia de Sao Carlos- - Universidade de Sao Paulo...Inorganic Materials IIC ASCR and ICT, Pelleova 24, Prague 6, Czech Republic blnstituto de Quimica - UNESP- C.P. 355, CEP: 14801-970, Araraquara, SP

Central cholinergic dysfunction could be associated with oropharyngeal dysphagia in early Parkinson's disease.

PubMed

Lee, Kyung Duck; Koo, Jung Hoi; Song, Sun Hong; Jo, Kwang Deog; Lee, Moon Kyu; Jang, Wooyoung

2015-11-01

Dysphagia is an important issue in the prognosis of Parkinson's disease (PD). Although several studies have reported that oropharyngeal dysphagia may be associated with cognitive dysfunction, the exact relationship between cortical function and swallowing function in PD patients is unclear. Therefore, we investigated the association between an electrophysiological marker of central cholinergic function, which reflected cognitive function, and swallowing function, as measured by videofluoroscopic studies (VFSS). We enrolled 29 early PD patients. Using the Swallowing Disturbance Questionnaire (SDQ), we divided the enrolled patients into two groups: PD with dysphagia and PD without dysphagia. The videofluoroscopic dysphagia scale (VDS) was applied to explore the nature of the dysphagia. To assess central cholinergic dysfunction, short latency afferent inhibition (SAI) was evaluated. We analyzed the relationship between central cholinergic dysfunction and oropharyngeal dysphagia and investigated the characteristics of the dysphagia. The SAI values were significantly different between the two groups. The comparison of each VFSS component between the PD with dysphagia group and the PD without dysphagia group showed statistical significance for most of the oral phase components and for a single pharyngeal phase component. The total score on the VDS was higher in the PD with dysphagia group than in the PD without dysphagia group. The Mini-Mental State Examination and SAI values showed significant correlations with the total score of the oral phase components. According to binary logistic regression analysis, SAI value independently contributed to the presence of dysphagia in PD patients. Our findings suggest that cholinergic dysfunction is associated with dysphagia in early PD and that an abnormal SAI value is a good biomarker for predicting the risk of dysphagia in PD patients.

An Exploration of the Relationship Between Spirituality and State and Trait Anger Among Medical Students.

PubMed

Kattimani, Shivanand; Sarkar, Siddharth; Bharadwaj, Balaji; Rajkumar, Ravi Philip

2015-12-01

There is a dearth of studies exploring spiritual attitudes of medical students from developing countries and its relationship to anger. This study was conducted to assess spiritual attitudes and their relationship with anger in a set of medical students in southern India. In this cross-sectional observational study, medical students who were undergoing clinical rotations were offered participation. Selected demographic data were obtained. The participants were rated using the Spiritual Attitudes Inventory [SAI, which comprises of Duke Religiosity Index, Existential Well-Being Scale (EWBS), Negative Religious Coping and Multidimensional Health Locus of Control scale] and State and Trait Anger Expression Inventory 2. Out of 98 students approached, 82 participated (response rate 83.6%). The mean age of sample was 20.7 years (±0.9 years) with a slight preponderance of females (54.9%). SAI scores correlated well significantly with subscale scores. Gender had no difference on the SAI or subscale score. Differences were found between self-reported religion and EWBS scores (Kruskal-Wallis χ(2) = 8.891, p = 0.012). Total SAI score had a significant negative correlation with state anger, trait anger and anger expression. High levels of spirituality may be correlated with lower levels of state anger, trait anger and anger expression in medical students.

Derivation of indices of socioeconomic status for health services research in Asia

PubMed Central

Earnest, Arul; Ong, Marcus E.H.; Shahidah, Nur; Chan, Angelique; Wah, Win; Thumboo, Julian

2015-01-01

Background Environmental contexts have been shown to predict health behaviours and outcomes either directly or via interaction with individual risk factors. In this paper, we created indexes of socioeconomic disadvantage (SEDI) and socioeconomic advantage (SAI) in Singapore to test the applicability of these concepts in an Asian context. These indices can be used for health service resource allocation, research and advocacy. Methods We used principal component analysis (PCA) to create SEDI and SAI using a structured and iterative process to identify and include influential variables in the final index. Data at the master plan geographical level was obtained from the most recent Singapore census 2010. Results The 3 areas with highest SEDI scores were Outram (120.1), followed by Rochor (111.0) and Downtown Core (110.4). The areas with highest SAI scores were Tanglin, River Valley and Newton. The SAI had 89.6% of variation explained by the final model, as compared to 67.1% for SEDI, and we recommend using both indices in any analysis. Conclusion These indices may prove useful for policy-makers to identify spatially varying risk factors, and in turn help identify geographically targeted intervention programs, which can be more cost effective to conduct. PMID:26844087

Analysis of the chronic lower limb injuries occurrence in step aerobic instructors in relation to their working step class profile: a three year longitudinal prospective study.

PubMed

Malliou, P; Rokka, S; Beneka, A; Gioftsidou, A; Mavromoustakos, S; Godolias, G

2014-01-01

There is limited information on injury patterns in Step Aerobic Instructors (SAI) who exclusively execute "step" aerobic classes. To record the type and the anatomical position in relation to diagnosis of muscular skeletal injuries in step aerobic instructors. Also, to analyse the days of absence due to chronic injury in relation to weekly working hours, height of the step platform, working experience and working surface and footwear during the step class. The Step Aerobic Instructors Injuries Questionnaire was developed, and then validity and reliability indices were calculated. 63 SAI completed the questionnaire. For the statistical analysis of the data, the method used was the analysis of frequencies, the non-parametric test χ^{2} (chi square distribution), correlation and linear and logistic regressions analysis from the SPSS statistical package. 63 SAI reported 115 injuries that required more than 2 days absence from step aerobic classes. The chronic lower extremity injuries were 73.5%, with the leg pain, the anterior knee pain, the plantar tendinopathy and the Achilles tendinopathy being most common overuse syndromes. The working hours, the platform height, the years of aerobic dance seem to affect the days of absence due to chronic lower limb injury occurrence in SAI.

Evolution of the snow area index of the subarctic snowpack in central Alaska over a whole season. consequences for the air to snow transfer of pollutants.

PubMed

Taillandier, A S; Domine, F; Simpson, W R; Sturm, M; Douglas, T A; Severin, K

2006-12-15

The detailed physical characteristics of the subarctic snowpack must be known to quantify the exchange of adsorbed pollutants between the atmosphere and the snow cover. For the first time, the combined evolutions of specific surface area (SSA), snow stratigraphy, temperature, and density were monitored throughout winter in central Alaska. We define the snow area index (SAI) as the vertically integrated surface area of snow crystals, and this variable is used to quantify pollutants' adsorption. Intense metamorphism generated by strong temperature gradients formed a thick depth hoar layer with low SSA (90 cm(2) g-1) and density (200 kg m(-3)), resulting in a low SAI. After snowpack buildup in autumn, the winter SAI remained around 1000 m(2)/m(2) of ground, much lower than the SAI of the Arctic snowpack, 2500 m(2) m-(2). With the example of PCBs 28 and 180, we calculate that the subarctic snowpack is a smaller reservoir of adsorbed pollutants than the Arctic snowpack and less efficiently transfers adsorbed pollutants from the atmosphere to ecosystems. The difference is greater for the more volatile PCB 28. With climate change, snowpack structure will be modified, and the snowpack's ability to transfer adsorbed pollutants from the atmosphere to ecosystems may be reduced, especially for the more volatile pollutants.

Insight in psychotic disorder: relation with psychopathology and frontal lobe function.

PubMed

Kumar, Atmesh; Sharma, Pranjal; Das, Shyamanta; Nath, Kamal; Talukdar, Uddip; Bhagabati, Dipesh

2014-01-01

Through conceptualising poor insight in psychotic disorders as a form of anosognosia, frontal lobe dysfunction is often ascribed a vital role in its pathogenesis. The objective of this study was to compare the relation of insight in patients with psychotic illness to that of psychopathology and frontal lobe function. Forty patients with psychotic disorder were selected from those attending the Department of Psychiatry in a tertiary care teaching hospital. The evaluation of insight was carried out using the Schedule for Assessment of Insight (SAI), that of frontal lobe function by the Frontal Assessment Battery (FAB) and psychopathology by the Brief Psychiatric Rating Scale (BPRS). The correlation coefficients were determined. A negative correlation between SAI and BPRS scores means that the BPRS score is opposite to SAI scores. When the SAI total score was compared with the FAB total score, the correlation coefficient demonstrated a positive correlation. Better insight predicted lesser psychopathology and also that poor insight would exist with greater psychopathology. Better insight predicted a higher functional status of frontal lobes and prefrontal cortex in particular. Insight deficits in schizophrenia and other psychotic illnesses are multidimensional. Integration of different aetiological factors like biological, psychopathological, environmental ones and others are necessary for a better understanding of insight in psychosis. Copyright © 2013 S. Karger AG, Basel.

UNICORN (Version III) Methodology.

DTIC Science & Technology

1976-10-01

rAD-A124 766 UNICORN CYERSION’III) NETHODOLOGYMU SCIENCE / APPLICATIONS INC ENGLEWOOD CO L M BLACKWELL ET AL. OCT 76 SAI-76-648-DEN DCAII-75-C-802...1ii4 4% 83 02 010GZ SAI-76-048-DEN .. UNICORN (VERSION III) METHODOLOGY TECHNICAL MEMORANDUM by core L. M. Blackwell . IF’l 4 H. E. Hock T. A. Kriz D...6 DISCUSSION .. ... ..... ..... ..... ..... ...... 7 FINDINGS AND CONCLUSIONS--THE UNICORN METHODOLOGY .. .. ... ..... 9

Systematic review and meta-analysis of short-acting insulin analogues in patients with diabetes mellitus.

PubMed

Plank, Johannes; Siebenhofer, Andrea; Berghold, Andrea; Jeitler, Klaus; Horvath, Karl; Mrak, Peter; Pieber, Thomas R

2005-06-27

This article compares the effect of treatment with short-acting insulin (SAI) analogues vs regular insulin on glycemic control, hypoglycemic episodes, quality of life, and diabetes-specific complications. Electronic searches (Cochrane Library, MEDLINE, and EMBASE) and additional searching (pharmaceutical companies, experts, approval agencies, abstracts of diabetology meetings) were performed. Two reviewers independently screened randomized controlled trials to determine inclusion. Forty-two randomized controlled trials that assessed the effect of SAI analogues vs regular insulin in 7933 patients with type 1 diabetes mellitus, type 2 diabetes mellitus, and gestational diabetes mellitus were identified. The weighted mean difference between hemoglobin A(1c) values obtained using SAI analogues and regular insulin was -0.12% (95% confidence interval [CI], -0.17% to -0.07%) for adult patients with type 1 diabetes mellitus and -0.02% (95% CI, -0.10% to 0.07%) for patients with type 2 diabetes mellitus. The standardized mean difference for overall hypoglycemia (episodes per patient per month) was -0.05 (95% CI, -0.22 to 0.11) and -0.04 (95% CI, -0.12 to 0.04) comparing SAI analogues with regular insulin in adult patients with type 1 and type 2 diabetes mellitus, respectively. No differences between treatments were observed in children with type 1 diabetes, pregnant women with type 1 diabetes mellitus, and women with gestational diabetes. Concerning quality of life, improvement was observed only in open-label studies in patients with type 1 diabetes mellitus. No differences were seen in a double-blinded study of patients with type 1 or in the studies of patients with type 2 diabetes mellitus. Our analysis suggests only a minor benefit to hemoglobin A(1c) values in adult patients with type 1 diabetes mellitus but no benefit in the remaining population with type 2 or gestational diabetes from SAI analogue treatment.

Bark Beetles Modify the Impact of Snow Drought on Remotely Sensed Forest Productivity in the Southern Rocky Mountains, USA

NASA Astrophysics Data System (ADS)

Knowles, J. F.; Lestak, L.; Molotch, N. P.

2016-12-01

We evaluated the long term (1989-2012) relationship between the satellite-observed Normalized Difference Vegetation Index (NDVI), snowpack accumulation, and atmospheric demand throughout the Southern Rocky Mountain Ecoregion, USA. Deviations from this relationship were further explored during pre- and post-disturbance conditions associated with bark beetles and drought. Over the entire study area, both the snow water equivalent (SWE) and a snow aridity index (SAI), which used the SWE to normalize potential evapotranspiration (PET), were significant predictors of the long-term AVHRR NDVI, but the SAI was a better predictor of NDVI relative to SWE regardless of disturbance. Since these relationships were weaker in disturbed areas, we also introduced a metric of tree mortality, and subsequent multiple linear regression of SAI and cumulative mortality best predicted the NDVI from a pair of heavily impacted focus areas within the larger study area. The post-disturbance NDVI was systematically reduced per unit SAI in these areas, and the difference between the observed and predicted (from pre-disturbance regressions) post-disturbance NDVI was significantly correlated with the cumulative forest mortality. At the Ecoregion scale, these disturbance effects were not clearly evident, and we attribute this to spatial variability of both SAI and NDVI throughout the large study area as evidenced by spatial analysis of Moderate Resolution Imaging Spectroradiometer (MODIS)-derived data. These results constrain the expected reduction in forest productivity due to disturbance and demonstrate that this reduction can be particularly evident during drought conditions resultant from low snow accumulation during the winter. Hence, terrestrial carbon uptake may decrease non-linearly post disturbance. This work has implications for predicting the ecohydrological response to climate change in the southern Rocky Mountains, as reductions in SWE and increases in PET are predicted for this area

Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults.

PubMed

Young-Bernier, Marielle; Tanguay, Annick N; Davidson, Patrick S R; Tremblay, François

2014-01-01

Cortical plasticity, including long-term potentiation (LTP)-like plasticity, can be assessed non-invasively with repetitive transcranial magnetic stimulation (rTMS) protocols. In this study, we examined age differences in responses to intermittent theta burst stimulation (iTBS) in a group of 20 young and 18 healthy older adults. Because the cholinergic system plays a role in the neural processes underlying learning and memory, including LTP, we also investigated whether short latency afferent inhibition (SAI), a neurophysiological marker of central cholinergic activity, would be associated with age-related differences in LTP-like plasticity induced by iTBS. SAI was first assessed by examining the modulation of motor evoked potentials (MEPs) in response to median nerve conditioning 20 ms prior to TMS. Participants then underwent iTBS (3 pulses at 50 Hz every 200 ms for 2 s with 8 s between trains, repeated 20 times). MEP responses (120% resting motor threshold (RMT)) were assessed immediately after iTBS and 5, 10, and 20 min post-application. Responses to iTBS were quite variable in both age groups, with only approximately 60% of the participants (n = 13 young and 10 older adults) showing the expected facilitation of MEP responses. There were no significant age group differences in MEP facilitation following iTBS. Although older adults exhibited reduced SAI, individual variations were not associated with susceptibility to express LTP-like induced plasticity after iTBS. Overall, these results are consistent with reports of high inter-individual variability in responses to iTBS. Although SAI was reduced in older adults, consistent with a deterioration of the cholinergic system with age, SAI levels were not associated with LTP-like plasticity as assessed with iTBS.

Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults

PubMed Central

Young-Bernier, Marielle; Tanguay, Annick N.; Davidson, Patrick S. R.; Tremblay, François

2014-01-01

Cortical plasticity, including long-term potentiation (LTP)-like plasticity, can be assessed non-invasively with repetitive transcranial magnetic stimulation (rTMS) protocols. In this study, we examined age differences in responses to intermittent theta burst stimulation (iTBS) in a group of 20 young and 18 healthy older adults. Because the cholinergic system plays a role in the neural processes underlying learning and memory, including LTP, we also investigated whether short latency afferent inhibition (SAI), a neurophysiological marker of central cholinergic activity, would be associated with age-related differences in LTP-like plasticity induced by iTBS. Methods: SAI was first assessed by examining the modulation of motor evoked potentials (MEPs) in response to median nerve conditioning 20 ms prior to TMS. Participants then underwent iTBS (3 pulses at 50 Hz every 200 ms for 2 s with 8 s between trains, repeated 20 times). MEP responses (120% resting motor threshold (RMT)) were assessed immediately after iTBS and 5, 10, and 20 min post-application. Results: Responses to iTBS were quite variable in both age groups, with only approximately 60% of the participants (n = 13 young and 10 older adults) showing the expected facilitation of MEP responses. There were no significant age group differences in MEP facilitation following iTBS. Although older adults exhibited reduced SAI, individual variations were not associated with susceptibility to express LTP-like induced plasticity after iTBS. Conclusion: Overall, these results are consistent with reports of high inter-individual variability in responses to iTBS. Although SAI was reduced in older adults, consistent with a deterioration of the cholinergic system with age, SAI levels were not associated with LTP-like plasticity as assessed with iTBS. PMID:25147523

Soft agar-based selection of spontaneously transformed rat prostate epithelial cells with highly tumorigenic characteristics.

PubMed

Gajdošik, Martina Šrajer; Hixson, Douglas C; Brilliant, Kate E; Yang, DongQin; De Paepe, Monique E; Josić, Djuro; Mills, David R

2018-05-29

The critical molecular and cellular mechanisms involved in the development and progression of prostate cancer remain elusive. In this report, we demonstrate that normal rat prostate epithelial cells (PEC) undergo spontaneous transformation at high passage (p > 85) evidenced by the acquisition of anchorage independent growth when plated on soft agar and tumorigenicity when injected into immunodeficient mice. In addition, we also report the discovery of a minor subpopulation of spontaneously transformed PEC derived from high passage PEC with the ability to migrate through a layer of 1% agar and form expanding colonies on the underlying plastic substratum. Comparison of these soft agar invasive (SAI) cells with low (p < 35), mid (p36-84) and high passage (p > 85) PEC identified marked differences in cell morphology, proliferation and motility. The SAI subpopulation was more tumorigenic than the high passage anchorage independent cultures from which they were isolated, as manifested by a decreased latency period and an increase in the size of tumors arising in immunodeficient mice. In contrast, low and mid passage cells were unable to grow on soft agar and failed to form tumors when injected into immunodeficient mice. Screening with antibody-based signaling arrays identified several differences in the altered expression levels of signaling proteins between SAI-derived cells and low or high passage PEC, including the up-regulation of EGFR and MAPK-related signaling pathways in SAI-selected cells. In summary, these studies suggest that the SAI assay selects for a novel, highly tumorigenic subpopulation of transformed cells that may represent an early step in the progression of slow growing prostatic carcinomas into more rapidly growing and aggressive tumors. Copyright © 2017. Published by Elsevier Inc.

Operational Prediction of the Habitat Suitability Index (HSI) Distribution for Neon Flying Squid in Central North Pacific by Using FORA Dataset and a New Data Assimilation System SKUIDS

NASA Astrophysics Data System (ADS)

Igarashi, H.; Ishikawa, Y.; Wakamatsu, T.; Tanaka, Y.; Nishikawa, S.; Nishikawa, H.; Kamachi, M.; Kuragano, T.; Takatsuki, Y.; Fujii, Y.; Usui, N.; Toyoda, T.; Hirose, N.; Sakai, M.; Saitoh, S. I.; Imamura, Y.

2016-02-01

The neon flying squid (Ommastrephes bartramii) has a wide-spread distribution in subtropical and temperate waters in the North Pacific, which plays an important role in the pelagic ecosystem and is one of the major targets in Japanese squid fisheries. The main fishing areas for Japanese commercial vessels are located in the central North Pacific (35-45N, around the date line) in summer. In this study, we have developed several kinds of habitat suitability index (HSI) models of the neon flying squid for investigating the relationship between its potential habitat and the ocean state variations in the target area. For developing HSI models, we have used a new ocean reanalysis dataset FORA (4-dimensional variational Ocean Re-Analysis) produced by JAMSTEC/CEIST and MRI-JMA. The horizontal resolution is 0.1*0.1 degree of latitude and longitude with 54 vertical levels, which can provide realistic fields of 3-dimensional ocean circulation and environmental structures including meso-scale eddies. In addition, we have developed a new 4D-VAR (4-dimensional variational) ocean data assimilation system for predicting ocean environmental changes in the main fishing grounds. We call this system "SKUIDS" (Scalable Kit of Under-sea Information Delivery System). By using these prediction fields of temperature, salinity, sea surface height, horizontal current velocity, we produced daily HSI maps of the neon flying squid, and provided them to the Japanese commercial vessels in operation. Squid fishermen can access the web site for delivering the information of ocean environments in the fishing ground by using Inmarsat satellite communication on board, and show the predicted fields of subsurface temperatures and HSI. Here, we present the details of SKUIDS and the web-delivery system for squid fishery, and some preliminary results of the operational prediction.

New social adaptability index predicts overall mortality.

PubMed

Goldfarb-Rumyantzev, Alexander; Barenbaum, Anna; Rodrigue, James; Rout, Preeti; Isaacs, Ross; Mukamal, Kenneth

2011-08-01

Definitions of underprivileged status based on race, gender and geographic location are neither sensitive nor specific; instead we proposed and validated a composite index of social adaptability (SAI). Index of social adaptability was calculated based on employment, education, income, marital status, and substance abuse, each factor contributing from 0 to 3 points. Index of social adaptability was validated in NHANES-3 by association with all-cause and cause-specific mortality. Weighted analysis of 19,593 subjects demonstrated mean SAI of 8.29 (95% CI 8.17-8.40). Index of social adaptability was higher in Whites, followed by Mexican-Americans and then the African-American population (ANOVA, p < 0.001). The SAI was higher in subjects living in metropolitan compared to rural areas (T-test, p < 0.001), and was greater in men than in women (T-test, p < 0.001). In Cox models adjusted for age, comorbidity index, BMI, race, sex, geographic location, hemoglobin, serum creatinine, albumin, cholesterol, and glycated hemoglobin levels, SAI was inversely associated with mortality (HR 0.87 per point, 95% CI 0.84-0.90, p < 0.001). This association was confirmed in subgroups. We proposed and validated an indicator of social adaptability with a strong association with mortality, which can be used to identify underprivileged populations at risk of death.

Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study.

PubMed

Crinò, Lucio; Dansin, Eric; Garrido, Pilar; Griesinger, Frank; Laskin, Janessa; Pavlakis, Nick; Stroiakovski, Daniel; Thatcher, Nick; Tsai, Chun-Ming; Wu, Yi-long; Zhou, Caicun

2010-08-01

Results of two phase 3 trials have shown first-line bevacizumab in combination with chemotherapy improves clinical outcomes in patients with advanced or recurrent non-squamous non-small-cell lung cancer (NSCLC). The SAiL (MO19390) study was undertaken to assess the safety and efficacy of first-line bevacizumab combined with standard chemotherapy regimens in clinical practice. Between August, 2006, and June, 2008, patients with untreated locally advanced, metastatic, or recurrent non-squamous NSCLC were recruited to this open-label, single group, phase 4 study from centres in 40 countries. Eligible patients had histologically or cytologically documented inoperable, locally advanced, metastatic, or recurrent disease (stage IIIB-IV); an Eastern Cooperative Oncology Group performance status of 0-2; and adequate haematological, hepatic, and renal function. Patients received bevacizumab (7.5 or 15 mg/kg every 3 weeks) plus standard chemotherapy for up to six cycles, followed by single-agent bevacizumab until disease progression. The primary endpoint was safety; analysis was by intention to treat (ITT). This study is registered with ClinicalTrials.gov, number NCT00451906. At the final data cutoff (July 24, 2009), an ITT population of 2212 patients was assessed. The incidence of clinically significant (grade > or = 3) adverse events of special interest was generally low; thromboembolism occurred in 172 (8%) patients, hypertension in 125 (6%), bleeding in 80 (4%), proteinuria in 67 (3%), and pulmonary haemorrhage in 15 (1%). 57 (3%) patients died because of these adverse events, with thromboembolism (26 patients, 1%) and bleeding (17, 1%) as the most common causes. The most common grade 3 or higher serious adverse events deemed by investigators to be associated with bevacizumab were pulmonary embolism (28 patients; 1%) and epistaxis, neutropenia, febrile neutropenia, and deep vein thrombosis (all of which occurred in 13 patients [1%]). Bevacizumab was temporarily

Change detection of bitemporal multispectral images based on FCM and D-S theory

NASA Astrophysics Data System (ADS)

Shi, Aiye; Gao, Guirong; Shen, Shaohong

2016-12-01

In this paper, we propose a change detection method of bitemporal multispectral images based on the D-S theory and fuzzy c-means (FCM) algorithm. Firstly, the uncertainty and certainty regions are determined by thresholding method applied to the magnitudes of difference image (MDI) and spectral angle information (SAI) of bitemporal images. Secondly, the FCM algorithm is applied to the MDI and SAI in the uncertainty region, respectively. Then, the basic probability assignment (BPA) functions of changed and unchanged classes are obtained by the fuzzy membership values from the FCM algorithm. In addition, the optimal value of fuzzy exponent of FCM is adaptively determined by conflict degree between the MDI and SAI in uncertainty region. Finally, the D-S theory is applied to obtain the new fuzzy partition matrix for uncertainty region and further the change map is obtained. Experiments on bitemporal Landsat TM images and bitemporal SPOT images validate that the proposed method is effective.

Microphysical Properties of Fog at Otis Air Force Base.

DTIC Science & Technology

1982-01-26

BKN 60VC 5 F SP1 2133 M3 OVC 3 F 2 0 SAI 2155 w2X 2 F 70170 21 08’ SAi 22551 wix I F in _ _ SP 2320 WIX 1/2 L-F21 0 SA; 23551 WIX 1/2 L F 6916 1 1 1...SAI 00551 WIX 1/2 L-F 699 21 - 0511/2 L-F 6 i8 IM 1__20_____10 SA, 5 5 WX 1/2 - F o3sI 2w-x -SA I 0455, WlX 1/2 F r7 r’ _2In SP 10535 i WIX 1/4 _ F...20 - 1. S~l_555 WiXI~114 _ F 166166 f SA!O5 WIX .L -i 1/4L r___ RS SP 1 07 4 0! --X - F 1 1 I_ US SP 0755, -X ES SKN F FiR 264 0 . SP 0815 -X 5SCT

Maritime over the Horizon Sensor Integration: High Frequency Surface-Wave-Radar and Automatic Identification System Data Integration Algorithm.

PubMed

Nikolic, Dejan; Stojkovic, Nikola; Lekic, Nikola

2018-04-09

To obtain the complete operational picture of the maritime situation in the Exclusive Economic Zone (EEZ) which lies over the horizon (OTH) requires the integration of data obtained from various sensors. These sensors include: high frequency surface-wave-radar (HFSWR), satellite automatic identification system (SAIS) and land automatic identification system (LAIS). The algorithm proposed in this paper utilizes radar tracks obtained from the network of HFSWRs, which are already processed by a multi-target tracking algorithm and associates SAIS and LAIS data to the corresponding radar tracks, thus forming an integrated data pair. During the integration process, all HFSWR targets in the vicinity of AIS data are evaluated and the one which has the highest matching factor is used for data association. On the other hand, if there is multiple AIS data in the vicinity of a single HFSWR track, the algorithm still makes only one data pair which consists of AIS and HFSWR data with the highest mutual matching factor. During the design and testing, special attention is given to the latency of AIS data, which could be very high in the EEZs of developing countries. The algorithm is designed, implemented and tested in a real working environment. The testing environment is located in the Gulf of Guinea and includes a network of HFSWRs consisting of two HFSWRs, several coastal sites with LAIS receivers and SAIS data provided by provider of SAIS data.

Dynamic modulation of corticospinal excitability and short-latency afferent inhibition during onset and maintenance phase of selective finger movement.

PubMed

Cho, Hyun Joo; Panyakaew, Pattamon; Thirugnanasambandam, Nivethida; Wu, Tianxia; Hallett, Mark

2016-06-01

During highly selective finger movement, corticospinal excitability is reduced in surrounding muscles at the onset of movement but this phenomenon has not been demonstrated during maintenance of movement. Sensorimotor integration may play an important role in selective movement. We sought to investigate how corticospinal excitability and short-latency afferent inhibition changes in active and surrounding muscles during onset and maintenance of selective finger movement. Using transcranial magnetic stimulation (TMS) and paired peripheral stimulation, input-output recruitment curve and short-latency afferent inhibition (SAI) were measured in the first dorsal interosseus and abductor digiti minimi muscles during selective index finger flexion. Motor surround inhibition was present only at the onset phase, but not at the maintenance phase of movement. SAI was reduced at onset but not at the maintenance phase of movement in both active and surrounding muscles. Our study showed dynamic changes in corticospinal excitability and sensorimotor modulation for active and surrounding muscles in different movement states. SAI does not appear to contribute to motor surround inhibition at the movement onset phase. Also, there seems to be different inhibitory circuit(s) other than SAI for the movement maintenance phase in order to delineate the motor output selectively when corticospinal excitability is increased in both active and surrounding muscles. This study enhances our knowledge of dynamic changes in corticospinal excitability and sensorimotor interaction in different movement states to understand normal and disordered movements. Published by Elsevier Ireland Ltd.

Anodal Direct Current Stimulation of the Cerebellum Reduces Cerebellar Brain Inhibition but Does Not Influence Afferent Input from the Hand or Face in Healthy Adults.

PubMed

Doeltgen, Sebastian H; Young, Jessica; Bradnam, Lynley V

2016-08-01

The cerebellum controls descending motor commands by outputs to primary motor cortex (M1) and the brainstem in response to sensory feedback. The cerebellum may also modulate afferent input en route to M1 and the brainstem. The objective of this study is to determine if anodal transcranial direct current stimulation (tDCS) to the cerebellum influences cerebellar brain inhibition (CBI), short afferent inhibition (SAI) and trigeminal reflexes (TRs) in healthy adults. Data from two studies evaluating effects of cerebellar anodal and sham tDCS are presented. The first study used a twin coil transcranial magnetic stimulation (TMS) protocol to investigate CBI and combined TMS and cutaneous stimulation of the digit to assess SAI. The second study evaluated effects on trigemino-cervical and trigemino-masseter reflexes using peripheral nerve stimulation of the face. Fourteen right-handed healthy adults participated in experiment 1. CBI was observed at baseline and was reduced by anodal cerebellar DCS only (P < 0.01). There was SAI at interstimulus intervals of 25 and 30 ms at baseline (both P < 0.0001), but cerebellar tDCS had no effect. Thirteen right-handed healthy adults participated in experiment 2. Inhibitory reflexes were evoked in the ipsilateral masseter and sternocleidomastoid muscles. There was no effect of cerebellar DCS on either reflex. Anodal DCS reduced CBI but did not change SAI or TRs in healthy adults. These results require confirmation in individuals with neurological impairment.

Skateboarding injuries in Vienna: location, frequency, and severity.

PubMed

Keilani, Mohammad; Krall, Christoph; Lipowec, Lucas; Posch, Martin; Komanadj, Tanya Sedghi; Crevenna, Richard

2010-07-01

To describe injury patterns of skateboard-associated injuries (SAIs) and to assess the frequency and severity of SAIs depending on an athlete's skateboarding experience. Cross-sectional observation. Skating areas. A total of 100 Viennese skateboarders. No intervention. The participants filled in a questionnaire that was used to assess selected sociodemographic data; duration and frequency of skateboarding; "stance"; and localization, rate, as well as the severity of SAIs during the past 24 months. Skating behavior and sociodemographic data were compared with frequency and severity of SAIs. Response rate of questionnaires was 75% (n=75) of the participants. Duration of skateboarding was 8+/-5 years, and training time was 18+/-11 hours/week. A total of 97% (73) of the respondents reported at least one injury: in 52% (39) of the respondents the most serious injury was mild to moderate (laceration, contusion, strain/sprain, and bruise), whereas in 45% (34) it was severe (ligament rupture, fracture). A total of 33% (13) of participants experiencing only mild-to-moderate injuries consulted a physician compared with 94% (32) with at least one serious injury. The most severely affected regions were lower leg/ankle/foot in 32% (24) of all respondents who experienced at least one severe injury and forearm/wrist/hand in 16% (12) who experienced at least one severe injury. Only 13% (10) used protective equipment. Multivariate logistic regression for the occurrence of at least one severe injury with all socioeconomic and sport-relevant data investigated revealed significant positive correlations with weekly training time (P=.037) and years of experience (P=.021). However, after correcting for multiple testing (Bonferroni adjustment for 8 tests), no significances remained. More experienced skateboarders seem to have a greater risk of incurring severe SAIs, but sociodemographic factors seem to have no influence on injury risk in this population. Only a minority of skateboarders

Predictors of early infection in cerebral ischemic stroke.

PubMed

Ashour, Wmr; Al-Anwar, A D; Kamel, A E; Aidaros, M A

2016-01-01

Infection is the most common complication of stroke. To determine the risk factors and predictors of post-stroke infection (PSI), which developed within 7 days from the onset of acute ischemic stroke. The study included 60 ischemic stroke patients admitted in the Neurology Department of Zagazig University, Egypt, who were subdivided into: [Non Stroke Associated Infection group (nSAI); 30 patients having stroke without any criteria of infection within 7 days from the onset and Stroke Associated Infection group (SAI); 30 patients having stroke with respiratory tract infection (RTI) or urinary tract infection within 7 days], in addition to 30 healthy sex and age-matching subjects as control. All the patients had a detailed history taking, thorough clinical general and neurological examination, laboratory tests (Urine analysis & urine culture, blood sugar, lipid profile and serum tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-10), a chest radiography to assess RTI and brain computed tomography (CT) to exclude the hemorrhagic stroke and to confirm the ischemic stroke. SAI patients were found to be significantly older with higher baseline blood glucose level. Also the number of patients with tube feeding, lower conscious level, more stroke severity and more large size infarcts were significantly higher in SAI patients. There was a significant elevation in the IL-10, a significant decrease in the TNF-α and a significant decrease in the TNF-α/ IL-10 ratio, in the SAI group. The baseline serum level of IL-10 ≥ 14.5 pg/ ml and size of infarct area > 3.5 cm3 were found to be the independent predictors of PSI. Patients with older age, tube feeding, lower conscious level, worse baseline stroke severity, large cerebral infarcts in CT scan, and increased IL-10 serum level were more susceptible to infection. The baseline serum level of IL-10 ≥ 14.5 pg/ ml and the size of infarct area > 3.5 cm3 were the independent predictors of PSI.

Predictors of early infection in cerebral ischemic stroke

PubMed Central

Ashour, WMR; Al-Anwar, AD; Kamel, AE; Aidaros, MA

2016-01-01

Background: Infection is the most common complication of stroke. Aim: To determine the risk factors and predictors of post-stroke infection (PSI), which developed within 7 days from the onset of acute ischemic stroke. Subjects: The study included 60 ischemic stroke patients admitted in the Neurology Department of Zagazig University, Egypt, who were subdivided into: [Non Stroke Associated Infection group (nSAI); 30 patients having stroke without any criteria of infection within 7 days from the onset and Stroke Associated Infection group (SAI); 30 patients having stroke with respiratory tract infection (RTI) or urinary tract infection within 7 days], in addition to 30 healthy sex and age-matching subjects as control. Methods: All the patients had a detailed history taking, thorough clinical general and neurological examination, laboratory tests (Urine analysis & urine culture, blood sugar, lipid profile and serum tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-10), a chest radiography to assess RTI and brain computed tomography (CT) to exclude the hemorrhagic stroke and to confirm the ischemic stroke. Results: SAI patients were found to be significantly older with higher baseline blood glucose level. Also the number of patients with tube feeding, lower conscious level, more stroke severity and more large size infarcts were significantly higher in SAI patients. There was a significant elevation in the IL-10, a significant decrease in the TNF-α and a significant decrease in the TNF-α/ IL-10 ratio, in the SAI group. The baseline serum level of IL-10 ≥ 14.5 pg/ ml and size of infarct area > 3.5 cm3 were found to be the independent predictors of PSI. Conclusion: Patients with older age, tube feeding, lower conscious level, worse baseline stroke severity, large cerebral infarcts in CT scan, and increased IL-10 serum level were more susceptible to infection. The baseline serum level of IL-10 ≥ 14.5 pg/ ml and the size of infarct area > 3.5 cm3 were the

Far-field optical imaging with subdiffraction resolution enabled by nonlinear saturation absorption

NASA Astrophysics Data System (ADS)

Ding, Chenliang; Wei, Jingsong

2016-01-01

The resolution of far-field optical imaging is required to improve beyond the Abbe limit to the subdiffraction or even the nanoscale. In this work, inspired by scanning electronic microscopy (SEM) imaging, in which carbon (or Au) thin films are usually required to be coated on the sample surface before imaging to remove the charging effect while imaging by electrons. We propose a saturation-absorption-induced far-field super-resolution optical imaging method (SAI-SRIM). In the SAI-SRIM, the carbon (or Au) layers in SEM imaging are replaced by nonlinear-saturation-absorption (NSA) thin films, which are directly coated onto the sample surfaces using advanced thin film deposition techniques. The surface fluctuant morphologies are replicated to the NSA thin films, accordingly. The coated sample surfaces are then imaged using conventional laser scanning microscopy. Consequently, the imaging resolution is greatly improved, and subdiffraction-resolved optical images are obtained theoretically and experimentally. The SAI-SRIM provides an effective and easy way to achieve far-field super-resolution optical imaging for sample surfaces with geometric fluctuant morphology characteristics.

Impacts of future radiation management scenarios on terrestrial carbon dynamics simulated with fully coupled NorESM

NASA Astrophysics Data System (ADS)

Ekici, Altug; Tjiputra, Jerry; Grini, Alf; Muri, Helene

2017-04-01

We have simulated 3 different radiation management geoengineering methods (CCT - cirrus cloud thinning; SAI - stratospheric aerosol injection; MSB - marine sky brightening) on top of future RCP8.5 scenario with the fully coupled Norwegian Earth System Model (NorESM). A globally consistent cooling in both atmosphere and soil is observed with all methods. However, precipitation patterns are dependent on the used method. Globally CCT and MSB methods do not affect the vegetation carbon budget, while SAI leads to a loss compared to RCP8.5 simulations. Spatially the most sensitive region is the tropics. Here, the changes in vegetation carbon content are related to the precipitation changes. Increase in soil carbon is projected in all three methods, the biggest change seen in SAI method. Simulations with CCT method leads to twice as much soil carbon retention in the tropics compared to the MSB method. Our findings show that there are unforeseen regional consequences of such geoengineering methods in the biogeochemical cycles and they should be considered with care in future climate policies.

An empirical examination of subjective age in older adults.

PubMed

Agogo, David; Hajjat, Fatima; Milne, George R; Schewe, Charles D; Perrott, Bruce

2017-01-01

It has been observed that subjective age (SA) often trails chronological age, especially in older adults. In a previously published article, we argued that differences in individual's SA is a function of their level of activity on biological, mental, and social dimensions. This article empirically tests this proposition using a newly created Subjective Aging Index (SAI). The SAI is related to SA above the effect of age with differences existing across age groups and sex. The findings contribute to the literature on successful aging strategies with important implications for health care practitioners, marketers, and individuals heading towards older adult years.

Command Flight Path Display. Phase I and II.

DTIC Science & Technology

1983-09-01

transmissions over the standard 56K baud interface. The PS-300 was a commercial unit and required some modifications to ensure its reliability in an...1 H7750-AA Battery Backup NADC 5 Oct E2 9 1 LA-12D Decwriter SAI/RtS 4 11ov 82 10 1 BC03M-25 Null Modem Cable SAI/RM0S 4 Nov 82 35 2 ~%*~’ .5°’ 11 1...of about 1200 baud. (The interface hardware is capable of 56K baud transmission, but the standard PS-300 firmware is only able to process input

A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement

PubMed Central

Ramalingam, Nagendran; Franke, Christof; Jaschinski, Evelin; Winterhoff, Moritz; Lu, Yao; Brühmann, Stefan; Junemann, Alexander; Meier, Helena; Noegel, Angelika A.; Weber, Igor; Zhao, Hongxia; Merkel, Rudolf; Schleicher, Michael; Faix, Jan

2015-01-01

Cell migration is driven by the establishment of disparity between the cortical properties of the softer front and the more rigid rear allowing front extension and actomyosin-based rear contraction. However, how the cortical actin meshwork in the rear is generated remains elusive. Here we identify the mDia1-like formin A (ForA) from Dictyostelium discoideum that generates a subset of filaments as the basis of a resilient cortical actin sheath in the rear. Mechanical resistance of this actin compartment is accomplished by actin crosslinkers and IQGAP-related proteins, and is mandatory to withstand the increased contractile forces in response to mechanical stress by impeding unproductive blebbing in the rear, allowing efficient cell migration in two-dimensional-confined environments. Consistently, ForA supresses the formation of lateral protrusions, rapidly relocalizes to new prospective ends in repolarizing cells and is required for cortical integrity. Finally, we show that ForA utilizes the phosphoinositide gradients in polarized cells for subcellular targeting. PMID:26415699

Can dysfunctional HDL explain high coronary artery disease risk in South Asians?

PubMed

Dodani, Sunita; Kaur, Rajwinderjit; Reddy, Srinavasa; Reed, Guy L; Navab, Mohammad; George, Varghese

2008-09-16

Coronary artery disease (CAD) is the leading cause of mortality and morbidity in United States, and South Asian immigrants (SAIs) have a higher risk for CAD compare to Caucasians. Traditional risk factors do not completely explain high risk, and some of the unknown risk factors need to be explored. We assessed dysfunctional pro-inflammatory high density lipoprotein (HDL) in SAIs and assessed its association with sub-clinical CAD using carotid intima-media thickness (IMT) as a surrogate marker for atherosclerosis. Cross-sectional study on SAIs aged 40-65 years. Sub-clinical CAD was measured using carotid intima media thickness (IMT) as a surrogate marker of atherosclerosis. Dysfunctional or pro-inflammatory HDL was determined by novel cell free assay and HDL inflammatory Index. Dysfunctional HDL was found in the 50% participants, with HDL-inflammatory index of >or=1.00, suggesting pro-inflammatory HDL (95% CI, 0.8772-1.4333). The prevalence of sub-clinical CAD using carotid IMT (>or=0.80 mm) was seen in 41.4% (95% CI, 0.2347-0.5933). On logistic regression analysis, positive carotid IMT was found to be associated with dysfunctional HDL after adjusting for age, family history of cardiovascular disease, and hypertension (p=0.030). The measurement of HDL level as well as functionality plays an important role in CAD risk assessment. Those SAIs with dysfunctional HDL and without known CAD can be a high risk group requiring treatment with lipid lowering drugs to reduce future risk of CAD. Further large studies are required to explore association of dysfunctional HDL with CAD and identify additional CAD risk caused by dysfunctional HDL.

Physical therapy students’ perceptions of team-based learning in gross anatomy using the Team-Based Learning Student Assessment Instrument

PubMed Central

2014-01-01

Purpose: The objective of this study was to assess physical therapy student perceptions of team-based learning (TBL) in a graduate level gross anatomy course using the TBL Student Assessment Instrument (TBL-SAI). Methods: The TBL-SAI was administered to 85 doctor of physical therapy (DPT) students, comprising three cohorts (classes of 2013, 2014, and 2015), who successfully completed a gross anatomy course where TBL was implemented. The TBL-SAI surveys 33 items, each rated from one (strongly disagree) to five (strongly agree) and measures three subscales: students’ perceptions of accountability, preference for lecture or TBL, and student satisfaction. Results: The means for each subscale and the total TBL-SAI score for each cohort fell above the neutral score. The 2015 group (mean, 37.97; 95% confidence interval [CI], 35.67 to 40.26) reported significantly higher satisfaction than that of the 2013 group (mean, 32.71; 95% CI, 30.31 to 35.05) and the 2014 group (mean, 33.11; 95% CI, 30.69 to 35.53). The 2015 group (mean, 125.3; 95% CI, 120.6 to 130.3) also had a significantly higher total score than that of the 2013 group (mean, 115.6; 95% CI, 110.5 to 120.5). Conclusion: The physical therapy students reported an overall positive experience in using TBL to learn gross anatomy in terms of accountability, preference for learning mode, and satisfaction. This positive experience with TBL was accompanied by their successful academic performance. Given the traits and learning preferences in this generation of graduate students, TBL could be a teaching method that is received positively elsewhere and results in successful academic performance and learning. PMID:24699446

A soil alteration index based on phospholipid fatty acids.

PubMed

Puglisi, Edoardo; Nicelli, Marco; Capri, Ettore; Trevisan, Marco; Del Re, Attilio A M

2005-12-01

Phospholipid fatty acid (PLFA) analysis has gained great importance in the study of soil microbial community structure. This structure can give indication of the soil status. Purpose of the present paper is to analyse PLFA patterns in altered agricultural soils in order to develop a soil status alteration index. Soils subjected either to intensive agricultural exploitation, or to overflow by municipal and industrial wastes, or to irrigation with saline waters were analysed for PLFA content and compared to adjacent untreated soils by means of different statistical techniques. Principal component analysis separated PLFAs in three groups: unsaturated PLFAs (first axis, 48% of total variance), monounsaturated and cyclopropane PLFAs (second axis, 28% of total variance) and polyunsaturated PLFAs (third axis, 24% of total variance). By means of canonical discriminant analysis, a soil alteration index (SAI) was produced from 15 PLFAs using two data sets. A third data set was used to test the SAI general validity together with other data sets reported in literature. The index validity was confirmed in most cases: SAI gave higher scores for control soils and was generally able to classify soils according to their reported degree of alteration.

Insight, psychosis, and depression in Africa: a cross-sectional survey from an inpatient unit in Ghana.

PubMed

Poole, Norman A; Crabb, Jim; Osei, Akwasi; Hughes, Peter; Young, David

2013-06-01

Few studies of the relationship of insight to psychopathology have been conducted in non-Western populations. This study examined the relationships between insight and depression, anxiety, and positive and negative symptoms on patients with schizophrenia resident in a psychiatric hospital in Ghana. A sample of 49 participants, (37 men and 12 women), with DSM-IV defined schizophrenia took part in semistructured interviews consisting of the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A); the Schedule for the Assessment of Insight - Expanded Version (SAI-E) and the Positive and Negative Syndrome Scale (PANSS). Bivariate correlations between variables were examined and those significantly correlated with an insight domain were included in multiple regression models. Variables associated with the total insight score were age, gender, anxiety symptoms, depression symptoms, and treatment compliance. In the final model, HAM-D positively predicted total SAI-E score, whilst PANSS-pos was negatively associated with total SAI-E score. The results are broadly consistent with those found in Western samples regarding insight and depressive symptoms. Implications of these results for competing theories of insight in psychoses are discussed. Patients able to identify themselves as ill may be aware of their affective symptoms.

Earth's future in the Anthropocene: Technological interventions between piecemeal and utopian social engineering

NASA Astrophysics Data System (ADS)

Schäfer, Stefan; Stelzer, Harald; Maas, Achim; Lawrence, Mark G.

2014-04-01

An extensive discussion in the academic and policy communities is developing around the possibility of climate engineering through stratospheric aerosol injection (SAI). In this contribution, we develop a perspective on this issue in the context of the wider setting of societal development in the Anthropocene. We draw on Karl Popper's concepts of piecemeal and utopian social engineering to examine how different visions of societal development relate to SAI. Based on this reflection, we argue that the debate on SAI is fueled not only by the inequitable distribution of its effects and potential atmospheric and climatic side effects, as disconcerting as some of these effects and side effects may be, but also, and perhaps primarily, by its apparent privileging of the status quo and incremental change over a more immediate and radical change in societal organization. Although differing ideological orientations might thus help explain the intensity of parts of the debate, the understanding from which they follow, in which societal development is deduced from postulated technological characteristics and assumptions about a technology's use, hides from view a more subtle understanding of the relationship between technology and politics.

Comparison of image registration based measures of regional lung ventilation from dynamic spiral CT with Xe-CT

PubMed Central

Ding, Kai; Cao, Kunlin; Fuld, Matthew K.; Du, Kaifang; Christensen, Gary E.; Hoffman, Eric A.; Reinhardt, Joseph M.

2012-01-01

Purpose: Regional lung volume change as a function of lung inflation serves as an index of parenchymal and airway status as well as an index of regional ventilation and can be used to detect pathologic changes over time. In this paper, the authors propose a new regional measure of lung mechanics—the specific air volume change by corrected Jacobian. The authors compare this new measure, along with two existing registration based measures of lung ventilation, to a regional ventilation measurement derived from xenon-CT (Xe-CT) imaging. Methods: 4DCT and Xe-CT datasets from four adult sheep are used in this study. Nonlinear, 3D image registration is applied to register an image acquired near end inspiration to an image acquired near end expiration. Approximately 200 annotated anatomical points are used as landmarks to evaluate registration accuracy. Three different registration based measures of regional lung mechanics are derived and compared: the specific air volume change calculated from the Jacobian (SAJ); the specific air volume change calculated by the corrected Jacobian (SACJ); and the specific air volume change by intensity change (SAI). The authors show that the commonly used SAI measure can be derived from the direct SAJ measure by using the air-tissue mixture model and assuming there is no tissue volume change between the end inspiration and end expiration datasets. All three ventilation measures are evaluated by comparing to Xe-CT estimates of regional ventilation. Results: After registration, the mean registration error is on the order of 1 mm. For cubical regions of interest (ROIs) in cubes with size 20 mm × 20 mm × 20 mm, the SAJ and SACJ measures show significantly higher correlation (linear regression, average r2 = 0.75 and r2 = 0.82) with the Xe-CT based measure of specific ventilation (sV) than the SAI measure. For ROIs in slabs along the ventral-dorsal vertical direction with size of 150 mm × 8 mm × 40 mm, the SAJ, SACJ, and SAI all show high

Marked phylogeographic structure of Gentoo penguin reveals an ongoing diversification process along the Southern Ocean.

PubMed

Vianna, Juliana A; Noll, Daly; Dantas, Gisele P M; Petry, Maria Virginia; Barbosa, Andrés; González-Acuña, Daniel; Le Bohec, Céline; Bonadonna, Francesco; Poulin, Elie

2017-02-01

Two main hypotheses have been debated about the biogeography of the Southern Ocean: (1) the Antarctic Polar Front (APF), acting as a barrier between Antarctic and sub-Antarctic provinces, and (2) the Antarctic Circumpolar Current (ACC), promoting gene flow among sub-Antarctic areas. The Gentoo penguin is distributed throughout these two provinces, separated by the APF. We analyzed mtDNA (HVR1) and 12 microsatellite loci of 264 Gentoo penguins, Pygoscelis papua, from 12 colonies spanning from the Western Antarctic Peninsula and the South Shetland Islands (WAP) to the sub-Antarctic Islands (SAI). While low genetic structure was detected among WAP colonies (mtDNA Ф ST =0.037-0.133; microsatellite F ST =0.009-0.063), high differentiation was found between all SAI and WAP populations (mtDNA Ф ST =0.678-0.930; microsatellite F ST =0.110-0.290). These results suggest that contemporary dispersal around the Southern Ocean is very limited or absent. As predicted, the APF appears to be a significant biogeographical boundary for Gentoo penguin populations; however, the ACC does not promote connectivity in this species. Our data suggest demographic expansion in the WAP during the last glacial maximum (LGM, about 20kya), but stability in SAI. Phylogenetic analyses showed a deep divergence between populations from the WAP and those from the SAI. Therefore, taxonomy should be further revised. The Crozet Islands resulted as a basal clade (3.57Mya), followed by the Kerguelen Islands (2.32Mya) as well as a more recent divergence between the Falkland/Malvinas Islands and the WAP (1.27Mya). Historical isolation, local adaptation, and past climate scenarios of those Evolutionarily Significant Units may have led to different potentials to respond to climate changes. Copyright © 2016 Elsevier Inc. All rights reserved.

Global electrical heterogeneity as a predictor of cardiovascular mortality in men and women.

PubMed

Lipponen, Jukka A; Kurl, Sudhir; Laukkanen, Jari A

2018-06-02

The aim of this study was to investigate the contribution of depolarization and repolarization abnormalities, specially abnormalities in global electrical heterogeneity of heart in cardiovascular disease (CVD) and all-cause mortality. Eight hundred and forty men and 911 women, average age of 63 years participated in this study with average follow-up was 14 years. Six electrocardiogram/vector electrocardiogram (ECG/VECG) markers QRS-duration, QTc-interval, QRST-angle, sum of absolute QRST integral (SAI QRST), T-wave roundness, and TV1-amplitude were estimated from VECG measurements. Hazard ratios (HRs) for CVD events (164 deaths) and all-cause mortality (383 deaths) for ECG parameters were calculated. Electrocardiogram or vector electrocardiogram parameter models adjusted for risk clinical factors showed that strongest predictors for CVD mortality were QRST-angle (HR 3.44, 95% confidence interval 2.12-5.36), QTc-interval (2.72, 1.73-4.29), and T-wave roundness (2.09, 1.26-3.46) among men. The strongest ECG/VECG parameters for CVD death were QRST-angle (2.47, 1.37-4.45), SAI QRST (2.37, 1.23-4.6), and QTc-interval (2.15, 1.16-4.01) among female participants. Multivariable adjusted models revealed that strongest independent ECG predictors for CVD death were QRST-angle, QTc-interval, resting heart rate, and T-roundness for men, QRST-angle and SAI QRST for women. QRST-angle, QTc-interval, resting heart rate, and T-roundness were associated with all-cause mortality in male population, although none of the ECG/VECG parameters predicted all-cause mortality among women. Characteristics of global electrical heterogeneity QRST-angle and QTc-interval in men and QRST-angle and SAI QRST among females were strong and independent risk markers for cardiovascular mortality. These parameters provide new additional ECG tools for cardiovascular risk stratification.

Safe disposal of toxic chrome buffing dust generated from leather industries.

PubMed

Swarnalatha, S; Srinivasulu, T; Srimurali, M; Sekaran, G

2008-01-31

The high concentration of trivalent chromium along with organic/inorganic compounds in chrome buffing dust (CBD), the solid waste discharged from leather industries, causes severe groundwater contamination on land co-disposal and chronic air pollution during thermal incineration. In the present investigation, CBD was subjected to starved air incineration (SAI) at 800 degrees C in a thermal incinerator under different flow rates of oxygen to optimize the oxygen required to incinerate the organic compounds and simultaneously preventing the conversion of Cr(3+) to Cr(6+). The energy audit of SAI of buffing dust under the external supply of oxygen was carried out under different incineration conditions. The bottom ash from SAI was effectively solidified/stabilized using Portland cement and fine aggregate. The solidified blocks were tested for unconfined compressive strength and heavy metal leaching. Unconfined compressive strength of the blocks was in the range of 120-180 kg/cm(2). The stabilization of chromium(III) in the cement gel matrix was confirmed using Scanning Electron Microscopy SEM, Electron Paramagnetic Resonance spectroscopy (EPR) and X-ray diffraction spectroscopy (XRD). Leachability studies through TCLP on solidified blocks were carried out to determine the degree of leaching of chromium and organic compounds (expressed as COD) under standard conditions.

Excess coronary artery disease risk in South Asian immigrants: Can dysfunctional high-density lipoprotein explain increased risk?

PubMed Central

Dodani, Sunita

2008-01-01

Background: Coronary artery disease (CAD) is the leading cause of mortality and morbidity in the United States (US), and South Asian immigrants (SAIs) have a higher risk of CAD compared to Caucasians. Traditional risk factors may not completely explain high risk, and some of the unknown risk factors need to be explored. This short review is mainly focused on the possible role of dysfunctional high-density lipoprotein (HDL) in causing CAD and presents an overview of available literature on dysfunctional HDL. Discussion: The conventional risk factors, insulin resistance parameters, and metabolic syndrome, although important in predicting CAD risk, may not sufficiently predict risk in SAIs. HDL has antioxidant, antiinflammatory, and antithrombotic properties that contribute to its function as an antiatherogenic agent. Recent Caucasian studies have shown HDL is not only ineffective as an antioxidant but, paradoxically, appears to be prooxidant, and has been found to be associated with CAD. Several causes have been hypothesized for HDL to become dysfunctional, including Apo lipoprotein A-I (Apo A-I) polymorphisms. New risk factors and markers like dysfunctional HDL and genetic polymorphisms may be associated with CAD. Conclusions: More research is required in SAIs to explore associations with CAD and to enhance early detection and prevention of CAD in this high risk group. PMID:19183743

Report: Strategic Agricultural Initiative Needs Revisions to Demonstrate Results

EPA Pesticide Factsheets

Report #2007-P-00040, September 26, 2007. The SAI program has not demonstrated how it fulfills its unique role of helping growers transition away from Food Quality Protection Act high-risk pesticides.

Comparison of virtual reality exergaming and home exercise programs in patients with subacromial impingement syndrome and scapular dyskinesis: Short term effect.

PubMed

Pekyavas, Nihan Ozunlu; Ergun, Nevin

2017-05-01

The aim of this study was to compare the short term effects of home exercise program and virtual reality exergaming in patients with subacromial impingement syndrome (SAIS). A total of 30 patients with SAIS were randomized into two groups which are Home Exercise Program (EX Group) (mean age: 40.6 ± 11.7 years) and Virtual Reality Exergaming Program (WII Group) (mean age: 40.33 ± 13.2 years). Subjects were assessed at the first session, at the end of the treatment (6 weeks) and at 1 month follow-up. The groups were assessed and compared with Visual Analogue Scale (based on rest, activity and night pain), Neer and Hawkins Tests, Scapular Retraction Test (SRT), Scapular Assistance Test (SAT), Lateral Scapular Slide Test (LSST) and shoulder disability (Shoulder Pain and Disability Index (SPADI)). Intensity of pain was significantly decreased in both groups with the treatment (p < 0.05). The WII Group had significantly better results for all Neer test, SRT and SAT than the EX Group (p < 0.05). Virtual reality exergaming programs with these programs were found more effective than home exercise programs at short term in subjects with SAIS. Level I, Therapeutic study. Copyright © 2017 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.

The Bayesian Decoding of Force Stimuli from Slowly Adapting Type I Fibers in Humans.

PubMed

Kasi, Patrick; Wright, James; Khamis, Heba; Birznieks, Ingvars; van Schaik, André

2016-01-01

It is well known that signals encoded by mechanoreceptors facilitate precise object manipulation in humans. It is therefore of interest to study signals encoded by the mechanoreceptors because this will contribute further towards the understanding of fundamental sensory mechanisms that are responsible for coordinating force components during object manipulation. From a practical point of view, this may suggest strategies for designing sensory-controlled biomedical devices and robotic manipulators. We use a two-stage nonlinear decoding paradigm to reconstruct the force stimulus given signals from slowly adapting type one (SA-I) tactile afferents. First, we describe a nonhomogeneous Poisson encoding model which is a function of the force stimulus and the force's rate of change. In the decoding phase, we use a recursive nonlinear Bayesian filter to reconstruct the force profile, given the SA-I spike patterns and parameters described by the encoding model. Under the current encoding model, the mode ratio of force to its derivative is: 1.26 to 1.02. This indicates that the force derivative contributes significantly to the rate of change to the SA-I afferent spike modulation. Furthermore, using recursive Bayesian decoding algorithms is advantageous because it can incorporate past and current information in order to make predictions--consistent with neural systems--with little computational resources. This makes it suitable for interfacing with prostheses.

The Bayesian Decoding of Force Stimuli from Slowly Adapting Type I Fibers in Humans

PubMed Central

Wright, James; Khamis, Heba; Birznieks, Ingvars; van Schaik, André

2016-01-01

It is well known that signals encoded by mechanoreceptors facilitate precise object manipulation in humans. It is therefore of interest to study signals encoded by the mechanoreceptors because this will contribute further towards the understanding of fundamental sensory mechanisms that are responsible for coordinating force components during object manipulation. From a practical point of view, this may suggest strategies for designing sensory-controlled biomedical devices and robotic manipulators. We use a two-stage nonlinear decoding paradigm to reconstruct the force stimulus given signals from slowly adapting type one (SA-I) tactile afferents. First, we describe a nonhomogeneous Poisson encoding model which is a function of the force stimulus and the force’s rate of change. In the decoding phase, we use a recursive nonlinear Bayesian filter to reconstruct the force profile, given the SA-I spike patterns and parameters described by the encoding model. Under the current encoding model, the mode ratio of force to its derivative is: 1.26 to 1.02. This indicates that the force derivative contributes significantly to the rate of change to the SA-I afferent spike modulation. Furthermore, using recursive Bayesian decoding algorithms is advantageous because it can incorporate past and current information in order to make predictions—consistent with neural systems—with little computational resources. This makes it suitable for interfacing with prostheses. PMID:27077750

Simulated transition from RCP8.5 to RCP4.5 through three different Radiation Management techniques

NASA Astrophysics Data System (ADS)

Muri, H.; Kristjansson, J. E.; Adakudlu, M.; Grini, A.; Lauvset, S. K.; Otterå, O. H.; Schulz, M.; Tjiputra, J. F.

2016-12-01

Scenario studies have shown that in order to limit global warming to 2°C above pre-industrial levels, negative CO2 emissions are required. Currently, no safe and well-established technologies exist for achieving such negative emissions. Hence, although carbon dioxide removal may appear less risky and controversial than Radiation Management (RM) techniques, the latter type of climate engineering (CE) techniques cannot be ruled out as a future policy option. The EXPECT project, funded by the Norwegian Research Council, explores the potential and risks of RM through Earth System Model Simulations. We here describe results from a study that simulates a 21st century transition from an RCP8.5 to a RCP4.5 scenario through Radiation Management. The study uses the Norwegian Earth System Model (NorESM) to compare the results from the following three RM techniques: a) Stratospheric Aerosol Injections (SAI); b) Marine Sky Brightening (MSB); c) Cirrus Cloud Thinning (CCT). All three simulations start from the year 2020 and run until 2100. Whereas both SAI and MSB successfully simulate the desired negative radiative forcing throughout the 21st century, the CCT simulations have a +0.5 W m-2 residual forcing (on top of RCP4.5) at the end of the century. Although all three techniques obtain approximately the same global temperature evolution, precipitation responses are very different. In particular, the CCT simulation has even more globally averaged precipitation at year 2100 than RCP8.5, whereas both SAI and MSB simulate less precipitation than RCP4.5. In addition, there are significant differences in geographical patterns of precipitation. Natural variability in the Earth System also exhibits sensitivity to the choice of RM technique: Both the Atlantic Meridional Overturning Circulation and the Pacific Decadal Oscillation respond differently to the choice of SAI, MSB or CCT. We will present a careful analysis, as well as a physical interpretation of the above results.

Structural and electrochemical studies of TiO2 complexes with (4,4'-((1E,1'E)-(2,5-bis(octyloxy)-1,4-phenylene)bis(ethene-2,1-diyl))bis-(E)-N-(2,5-bis(octyloxy)benzylidene)) imine derivative bases towards organic devices.

PubMed

Rozycka, Anna; Iwan, Agnieszka; Bogdanowicz, Krzysztof Artur; Filapek, Michal; Górska, Natalia; Hreniak, Agnieszka; Marzec, Monika

2018-06-12

Three (4,4'-((1E,1'E)-(2,5-bis(octyloxy)-1,4-phenylene)bis(ethene-2,1-diyl))bis-(E)-N-(2,5-bis(octyloxy)benzylidene)) imine derivatives were synthesized via a condensation reaction with p-toluenesulfonic acid as a catalyst. The effects of the end groups and vinylene (-HC[double bond, length as m-dash]CH-) moieties on the structural, thermal, optical, electrochemical and photovoltaic properties of imines were investigated to check the influence of TiO2 on the imine properties. The thermal behavior of imines and their complexes with TiO2 was widely investigated using FT-IR, XRD, DSC and POM methods in order to determine the order type in the imine structure. All imines present the highest occupied molecular orbital (HOMO) levels of about -5.39 eV (SAI1 and SAI2) and -5.27 eV (SAI3) and the lowest unoccupied molecular orbital (LUMO) levels at about -3.17 eV. The difference of the end groups in the imines in each case did not affect redox properties. Generally, both oxidation and reduction are easier after TiO2 addition and it also changes the HOMO-LUMO levels of imines. Moreover, changes in the characteristic bands for imines in the region 1500-1700 cm-1 observed as a drastic decrease of intensity or even disappearance of bands in the imine : TiO2 mixture suggest the formation of a complex (C[double bond, length as m-dash]N)-TiO2. Organic devices with the configuration of ITO/TiO2/SAIx (or SAIx : TiO2)/Au were fabricated and investigated in the presence and absence of visible light irradiation with an intensity of 93 mW cm-2. In all imines and complexes with TiO2, the generation of the photocurrent indicates their use as photodiodes and the best result was observed for SAI3 : TiO2 complexes.

A wake-up call. NGO / Youth Fora.

PubMed

Inayatullah, A

1999-01-01

The client first, informed choice, and quality of care approach to reproductive health is being applied around the world, energized by individuals, communities, and organizations. There has been unprecedented support during the Cairo+5 global review process of the centrality of youth in the process, for by 2000, approximately 1 billion people aged 15-24 years will either be in or entering their reproductive years, the largest generation ever in this age cohort. These young people face considerable reproductive health risks and poor access to information and services. In addition, 25% of children are assaulted or abused, and 20% live in poverty. The Youth Forum recommendations will help to ensure that the reproductive health and social development needs of the world's youth are properly met. However, to fully implement the International Conference on Population and Development (ICPD) program of action, donor governments need to meet their funding commitments.

Abnormal corticospinal excitability in patients with disorders of consciousness.

PubMed

Lapitskaya, Natallia; Gosseries, Olivia; De Pasqua, Victor; Pedersen, Asger Roer; Nielsen, Joergen Feldbaek; de Noordhout, Alain Maertens; Laureys, Steven

2013-07-01

Transcranial magnetic stimulation (TMS) has been frequently used to explore changes in the human motor cortex in different conditions, while the extent of motor cortex reorganization in patients in vegetative state (VS) (now known as unresponsive wakefulness syndrome, UWS) and minimally conscious (MCS) states due to severe brain damage remains largely unknown. It was hypothesized that cortical motor excitability would be decreased and would correlate to the level of consciousness in patients with disorders of consciousness. Corticospinal excitability was assessed in 47 patients (24 VS/UWS and 23 MCS) and 14 healthy controls. The test parameters included maximal peak-to-peak M-wave (Mmax), F-wave persistence, peripheral and central motor conduction times, sensory (SEP) and motor evoked (MEP) potential latencies and amplitudes, resting motor threshold (RMT), stimulus/response curves, and short latency afferent inhibition (SAI). TMS measurements were correlated to the level of consciousness (assessed using the Coma Recovery Scale-Revised). On average, the patient group had lower Mmax, lower MEP and SEP amplitudes, higher RMTs, narrower stimulus/response curves, and reduced SAI compared to the healthy controls (P < 0.05). The SAI alterations were correlated to the level of consciousness (P < 0.05). The findings demonstrated the impairment of the cortical inhibitory circuits in patients with disorders of consciousness. Moreover, the significant relationship was found between cortical inhibition and clinical consciousness dysfunction. Copyright © 2013 Elsevier Inc. All rights reserved.

A Combined Ethical and Scientific Analysis of Large-scale Tests of Solar Climate Engineering

NASA Astrophysics Data System (ADS)

Ackerman, T. P.

2017-12-01

Our research group recently published an analysis of the combined ethical and scientific issues surrounding large-scale testing of stratospheric aerosol injection (SAI; Lenferna et al., 2017, Earth's Future). We are expanding this study in two directions. The first is extending this same analysis to other geoengineering techniques, particularly marine cloud brightening (MCB). MCB has substantial differences to SAI in this context because MCB can be tested over significantly smaller areas of the planet and, following injection, has a much shorter lifetime of weeks as opposed to years for SAI. We examine issues such as the role of intent, the lesser of two evils, and the nature of consent. In addition, several groups are currently considering climate engineering governance tools such as a code of ethics and a registry. We examine how these tools might influence climate engineering research programs and, specifically, large-scale testing. The second direction of expansion is asking whether ethical and scientific issues associated with large-scale testing are so significant that they effectively preclude moving ahead with climate engineering research and testing. Some previous authors have suggested that no research should take place until these issues are resolved. We think this position is too draconian and consider a more nuanced version of this argument. We note, however, that there are serious questions regarding the ability of the scientific research community to move to the point of carrying out large-scale tests.

Synthetic aperture integration (SAI) algorithm for SAR imaging

DOEpatents

Chambers, David H; Mast, Jeffrey E; Paglieroni, David W; Beer, N. Reginald

2013-07-09

A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

Pattern of online communication in teaching a blended oral surgery course.

PubMed

Marei, H F; Al-Khalifa, K S

2016-11-01

To explore the factors that might affect the patterns of interaction amongst dental students that can be found in asynchronous online discussion fora. It is a qualitative study that involved the participation of 71 dental students (42 male and 29 female) who belong to one academic year. Students were participated in asynchronous online discussion fora as a part of a blended oral surgery course that involved both face-to-face lecture and an online learning environment using the Blackboard learning management system. Qualitative analysis of students' pattern of discussion was performed using Transcript Analysis Tool. The total number of postings was 410. Sixty-seven of 71 students participated in the discussion by writing posts, whereas all of the students had accessed all of the postings. A positive correlation between imposing vertical questions and the number of non-referential and referential statements was observed. Regarding horizontal questions, a positive correlation was observed with the number of referential statements, whilst there was a negative correlation with the number of non-referential statements. Asynchronous online discussion fora that are integrated as a part of a whole pedagogical practice may provide an opportunity for promoting learning, especially when consideration is given to the structure of problems, timely feedback by tutors and supportive strategies within the discussion threads. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Assessing the Snow Advance Index as potential predictor of winter streamflow of the Iberian Peninsula Rivers

NASA Astrophysics Data System (ADS)

Hidalgo-Muñoz, José Manuel; García-Valdecasas-Ojeda, Matilde; Raquel Gámiz-Fortis, Sonia; Castro-Díez, Yolanda; Jesús Esteban-Parra, María

2015-04-01

This study examines the ability of the Eurasian snow cover increase during the previous October as potential predictor of winter streamflow in the Iberian Peninsula Rivers. The streamflow data base used has been provided by the Center for Studies and Experimentation of Public Works, CEDEX. Series from gauging stations and reservoirs with less than 10% of missing data (filled by regression with well correlated neighboring stations) have been considered. The homogeneity of these series has been evaluated through the Pettit test and degree of human alteration by the Common Area Index. The application of these criteria led to the selection of 382 streamflow time series homogeneously distributed over the Iberian Peninsula, covering the period 1975-2008. For this streamflow data, winter seasonal values were obtained by averaging the monthly values from January to March. The recently proposed Snow Advance Index (SAI) was employed to monitor the snow cover increase during previous October. The stability of the correlations was the criterion followed to establish if SAI could be considered as potential predictor of winter streamflow at each gauging station. Winter streamflow is predicted using a linear regression model. A leave-one-out cross validation approach was adopted to create calibration and validations subsets. The correlation coefficient (RHO), Root Mean Square Error Skill Score (RMSESS) and the Gerrity Skill Score (GSS) were used to evaluate the forecasting skill. From the 382 stations evaluated, significant and stable correlations with SAI were found in 238 stations, covering most of the IP (except for the Cantabrian and Mediterranean slopes). Some forecasting skill was found in 223 of them, being this skill moderate (RHO>0.44, RMSESS>10%, GSS>0.2) in 141 of them, and particularly good (RHO>0.5, RMSESS>20%, GSS>0.4) in 23. This study shows that the SAI of previous October is a reliable predictor of following winter streamflow for the Iberian Peninsula Rivers

Expression analysis of genes associated with sucrose accumulation in sugarcane (Saccharum spp. hybrids) varieties differing in content and time of peak sucrose storage

USDA-ARS?s Scientific Manuscript database

Sucrose synthesis/accumulation in sugarcane is a complex process involving many genes and regulatory sequences that control biochemical events in source-sink tissues. Among these, sucrose synthase (SuSy), sucrose-phosphate synthase (SPS), soluble acid (SAI) and cell-wall invertase (CWI) are importan...

Microcomputer spacecraft thermal analysis routines (MSTAR) Phase I: The user interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teti, N.M.

1993-12-31

The Microcomputer Spacecraft Thermal Analysis Routines (MSTAR) software package is being developed for NASA/Goddard Space Flight Center by Swales and Associates, Inc. (S&AI). In December 1992, S&AI was awarded a phase I Small Business Inovative Research contract fronm NASA to develop a microcomputer based thermal analysis program to replace the current SSPTA and TRASYS programs. Phase I consists of a six month effort which will focus on developing geometric model generation and visualization capabilities using a graphical user interface (GUI). The information contained in this paper encompasses the work performed during the Phase I development cycle; with emphasis on themore » development of the graphical user interface (GUI). This includes both the theory behind and specific examples of how the MSTAR GUI was implemented. Furthermore, this report discusses new applications and enhancements which will improve the capabilities and commercialization of the MSTAR program.« less

Shellfish conflict in Baynes Sound: a strategic perspective.

PubMed

Hamouda, Luai; Hipel, Keith W; Kilgour, D Marc

2004-10-01

The shellfish aquaculture industry (SAI) has operated in Baynes Sound, British Columbia (BC) since the early 1900s. Recognizing the economic potential of the area, the industry has requested additional farming opportunities. However, Baynes Sound upland residents and many other stakeholders have expressed concerns that SAI activities are having a negative impact on the environment, quality of life, and other nonaquaculture resource uses in the area. In order to address these issues, the Action Plan was initiated by a BC government interagency project team in November 2001. To assist in assessing the strategic aspects of this conflict, the decision support system GMCR II is employed here to apply a new methodology, the graph model for conflict resolution, to systematically analyze the ongoing conflict over shellfish aquaculture development in Baynes Sound within a social, economic, and environmental framework. Valuable insights are procured to guide decision-makers toward sustainability of the shellfish industry.

Seeing and optimization of the thermal regime in the dome of 1.5-m Telescope Maidanak Observatory

NASA Astrophysics Data System (ADS)

Artamonov, Boris P.

1997-03-01

Beginning in 1975 Sternberg Astronomical Institute of Moscow University (SAI) developed a search of places with the best astroclimate in Middle Asia. Mount Maidanak (150 km to south from Samarkand) was chosen after investigation of the meteorological conditions, temperature fluctuations and seeing quality by astroclimatical expeditions in a different city testing for Moscow University Observatory. Having an isolated summit Maidanak has good astroclimatical parameters: 2000 clean observational hours/year, median seeing about 0.7 arcsec (Artamonov et al. 1987, Bugaenko et al. 1992). At the end of 1992 SAI mainly finished the construction of Maidanak Observatory with a 1.5 meter RC telescope, but in 1993 the development of the observatory was stopped after nationalization by Uzbekistan. At present Sternberg Astronomical Institute and Tashkent Astronomical Institute (new owner of the observatory) continue to work in joint observations and try to create International Maidanak Observatory.

Microcomputer spacecraft thermal analysis routines (MSTAR) Phase I: The user interface

NASA Technical Reports Server (NTRS)

Teti, Nicholas M.

1993-01-01

The Microcomputer Spacecraft Thermal Analysis Routines (MSTAR) software package is being developed for NASA/Goddard Space Flight Center by Swales and Associates, Inc. (S&AI). In December 1992, S&AI was awarded a phase I Small Business Inovative Research contract fronm NASA to develop a microcomputer based thermal analysis program to replace the current SSPTA and TRASYS programs. Phase I consists of a six month effort which will focus on developing geometric model generation and visualization capabilities using a graphical user interface (GUI). The information contained in this paper encompasses the work performed during the Phase I development cycle; with emphasis on the development of the graphical user interface (GUI). This includes both the theory behind and specific examples of how the MSTAR GUI was implemented. Furthermore, this report discusses new applications and enhancements which will improve the capabilities and commercialization of the MSTAR program.

The effects of preoperative aromatherapy massage on anxiety and sleep quality of colorectal surgery patients: A randomized controlled study.

PubMed

Ayik, Cahide; Özden, Dilek

2018-02-01

To examine the effects of aromatherapy massage on anxiety and sleep quality in patients undergoing colorectal surgery in the preoperative period. In recent years, there has been an increase in the number of studies conducted on aromatherapy massage. It is stated that studies conducted on aromatherapy massage for anxiety and sleep quality reveal contradictory results and that more research is required on the issue. A randomized controlled trial. Eighty patients undergoing colorectal surgery were randomly assigned to experimental and control group. To the experimental group (n = 40), aromatherapy massage was applied in accordance with the "Back Massage Guide" using 5% lavender oil (Lavandula Hybrida) for ten minutes before surgery and the morning of surgery. The control group received standard nursing care in compliance with the hospital procedure. Data were obtained by the State Anxiety Inventory (SAI) and Richard-Campbell Sleep Questionnaire (RCSQ). Results were analyzed using the t-test, Chi-square test or Fisher's exact test. There was no baseline difference between the groups. A statistically significant difference was found between the experimental and control group in terms of the SAI and RCSQ mean scores recorded on the morning of surgery. It was determined that the SAI and RCSQ mean score of the experimental group after aromatherapy massage on the morning of surgery decreased when compared to that of the evening before surgery. It was found that aromatherapy massage with lavender oil increased the sleep quality and reduced the level of anxiety in patients with colorectal surgery in the preoperative period. Copyright © 2017 Elsevier Ltd. All rights reserved.

77 FR 27100 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... of the registration process is to provide disclosure of financial and other information to investors... to provide investors with a prospectus and a statement of additional information (``SAI'') covering essential information about the separate account when it makes an initial or additional offering of its...

STUDY USING A THREE-DIMENSIONAL SMOG FORMATION MODEL UNDER CONDITIONS OF COMPLEX FLOW

EPA Science Inventory

To clarify the photochemical smog formation mechanisms under conditions of complex flow, the SAI Urban Airshed Model was evaluated using a 1981 field observed data base. In the Tokyo Metropolitan Area higher O3 concentrations are usually observed near the shore in the morning. As...

Rapid re-brightening of the red nova V4332 Sgr remnant

NASA Astrophysics Data System (ADS)

Goranskij, V. P.; Zharova, A. V.; Barsukova, E. A.; Valeev, A. F.

2018-06-01

V4332 Sgr is a luminous red nova exploded in 1994. We perform CCD BVRcIc photometry of its remnant since 2003, and medium resolution spectroscopy since 2005 using Russian 6 m telescope BTA, SAO 1 m Zeiss telescope and smaller telescopes of SAI Crimean Station.

77 FR 5308 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

............ GRIMM KATJA GROENEN FRANK GRONER ELIYAHU DAVID GRONING MARC E GUNNARSSON GUNNAR-THOR....... BJORNSSON... ARTHUR HANSSON KARL STEFAN HARPER-VANDAMME BRENDA CHRISTIAN HARVEY BRUCE E HARVEY RALPH DIETER HASLER... HILLIARD ELAINE GARDINER WELCH HO LESLIE SAI KIT HOCHHEIMER SUZANNE TRUDY HOLUB BARBARA RENE HRYNIUK LYNN E...

Breadth and Intensity: Salient, Separable, and Developmentally Significant Dimensions of Structured Youth Activity Involvement

ERIC Educational Resources Information Center

Busseri, Michael A.; Rose-Krasnor, Linda

2009-01-01

In recent years, an impressive volume of evidence has accumulated demonstrating that youth involvement in structured, organized activities (e.g. school sports, community clubs) may facilitate positive youth development. We present a theory-based framework for studying structured activity involvement (SAI) as a context for positive youth…

Professional Development Urban Schools: What Do Teachers Say?

ERIC Educational Resources Information Center

Green, Tanya R.; Allen, Mishaleen

2015-01-01

This quantitative causal-comparative study compared perceptions of professional development opportunities between high-achieving and low-achieving elementary-middle school teachers in an urban school district using the Standards Assessment Inventory (SAI). A total of 271 teachers participated including 134 (n = 134) teachers from high-achieving…

The obtaining relative position of lunar centre masses and centre of the figure in selenocentric catalogues

NASA Astrophysics Data System (ADS)

Nefedjev, Yu. A.; Valeev, S. G.; Rizvanov, N. G.; Mikeev, R. R.; Varaksina, N. Yu.

2010-05-01

The relative position of lunar center masses relative to center of the figure in Kazan and Kiev selenocentric catalogues was customized. The expansions by spherical harmonics N=5 degree and order of the lunar function h(λ, β) with using the package ASNI USTU were executed. Module of the expansion of the local area to surfaces to full sphere was used. The parameters of cosmic missions are given for comparison (SAI; Bills, Ferrari). The normalized coefficients from expansions for eight sources hypsometric information are obtained: - Clementine (N=40), - Kazan (N=5), - Kiev (N=5), - SAI (N=10; Chuikova (1975)), - Bills, Ferrari, - Каguуа (Selena, Japan mission), - ULCN (The Uuified Lunaz Control Network 2005). The displacements of the lunar centre figure relative to lunar centre of the masses were defined from equations (Chuikova (1975)). The results of the obtaining relative position of the lunar centre masses and centre of the figure in Kazan selenocentric catalogue give good agreement with modern cosmic mission data.

The U.S. Army in Asia: Opportunities and Challenges Report of a Workshop of Experts

DTIC Science & Technology

2013-08-01

the staff of a member of the National Diet . Dr. Green received his master’s and doctoral degrees from SAIS and did additional graduate and...operational assignment was as an AV-8A Harrier Pilot, in which he completed numerous deployments to both the Mediterranean Sea and Okinawa. Major

Washington State Student Achievement Initiative Policy Study: Final Report

ERIC Educational Resources Information Center

Jenkins, Davis; Wachen, John; Moore, Colleen; Shulock, Nancy

2012-01-01

In 2007, the Washington State Board for Community and Technical Colleges launched a performance funding policy called the Student Achievement Initiative (SAI) both to improve public accountability by more accurately describing what students achieve from enrolling in community colleges and to provide incentives to colleges through financial rewards…

NAREM Journal. Volume 1, 1978.

ERIC Educational Resources Information Center

Narem Journal, 1978

1978-01-01

Eight articles are included in the journal of the National Association for Remedial Education, Malaysia (NAREM). Chua Tee Tee describes the history and objectives of NAREM. Alec Williams reviews philosophical issues in remedial education. Khoo Phon Sai discusses cognitive, social, and emotional characteristics of slow learners and considers…

Study Abroad Information in the New Media

ERIC Educational Resources Information Center

Teng, Shasha; Khong, Kok Wei; Chong, Alain Yee Loong

2015-01-01

Few studies have been conducted to identify what kinds of online information are provided by institutions and needed by international students in social media. This study aims to identify critical constructs of study abroad information (SAI) that can generate positive attitudes toward the university. Specifically, this study attempts to…

Typical Intellectual Engagement as a Byproduct of Openness, Learning Approaches, and Self-Assessed Intelligence

ERIC Educational Resources Information Center

Arteche, Adriane; Chamorro-Premuzic, Tomas; Ackerman, Phillip; Furnham, Adrian

2009-01-01

Students (n = 328) from US and UK universities completed four self-report measures related to intellectual competence: typical intellectual engagement (TIE), openness to experience, self-assessed intelligence (SAI), and learning approaches. Confirmatory data reduction was used to examine the structure of TIE and supported five major factors:…

The Point of the Point: Washington's Student Achievement Initiative through the Looking Glass of a Community College

ERIC Educational Resources Information Center

Li, Amy Y.

2017-01-01

For 8 years Washington State has operated a performance funding policy, the Student Achievement Initiative (SAI). The policy allocates appropriations to the state's 34 community and technical colleges based on points earned through student achievement of college-readiness, retention, and completion milestones. Grounded in a conceptual framework of…

MOLECULAR PHYLOGENY OF LARGE MILIOLID FORAMINIFERA. (R825869)

EPA Science Inventory

Abstract

The foraminiferal superfamily Soritacea belongs to the suborder Miliolina and is divided in two families, Peneroplidae and Soritidae, the latter one comprising two subfamilies, Archaiasinae and Soritinae. Phylogenetic relationships of 11 genera of soritid fora...

"It Sais I Have a D How that Be"

ERIC Educational Resources Information Center

Russell, Connie

2009-01-01

We've all gotten them--the student emails that make you question your decision to get into this profession. The title of this column says it all. If we want students to meet our expectations, we must give them instruction on what we expect. Technology should be used to help us meet our academic goals, not just to cater to students' love of…

[Relationship of insight with depression and suicidal ideation in psychotic disorders].

PubMed

Patelaros, E; Zournatzis, E; Kontstantakopoulos, G

2015-01-01

The associations of insight into psychosis (i.e., awareness of illness) with clinical variables have been examined by a great number of studies. Most of these studies revealed that the level of insight is negatively correlated with psychotic symptoms but positively correlated with depression and suicidal ideation. The aim of this study was to test these findings in a Greek sample of patients. Forty-three outpatients (30 men and 13 women) with schizophrenia or delusional disorder being followed up at the Mental Health Centre of Kavala took part in the study. Patients with bipolar or schizoaffective disorder were excluded. Patients' mean age was 40.7 years and the mean duration of illness was 18.67 years. All participants were under treatment and clinically stable at the time of the study. We used the Positive and Negative Syndrome Scale (PANSS) for the assessment of positive and negative symptoms, the Schedule for the Assessment of Insight-Expanded (SAI-E) to assess the insight into psychosis, and the Montgomery-Asberg Depression Rating Scale (MADRS) for the evaluation of depression recording separately the score for item 10 as an estimate of suicidal ideation. All the scales used have been adapted to Greek population. We used Spearman rho coefficient to assess the strength of correlations between the scales because the distributions of some scores were not normal. In order to assess the predictive value of insight for depression and suicidal ideation, we used hierarchical linear regression analysis. Correlation coefficients between SAI-E and the clinical scales of psychopathology, depression and suicide ideation was statistically significant at the p<0.01 level. The correlations between the clinical scales and the three subscales of SAI-E were also significant at the aforementioned p level. The regression analysis showed that our model of positive and negative psychopathology and insight explained 47.4% of the variance of depression and 32.2% of the variance of

Self-Assessed Intelligence: Inter-Ethnic, Rural-Urban, and Sex Differences in Malaysia

ERIC Educational Resources Information Center

Swami, Viren; Furnham, Adrian

2010-01-01

The present study examined inter-ethnic, rural-urban, and sex differences in self-assessed intelligence (SAI) in a Malaysian general population sample. In total, 633 individuals varying in rural or urban location, ethnicity (Malay, Kadazan, and Bajau), and sex (women versus men) provided their self-assessed overall intelligence and ten multiple…

The User Perspective in Performance Auditing--A Case Study of Norway

ERIC Educational Resources Information Center

Arthur, Arnfrid; Rydland, Lars Tore; Amundsen, Kristin

2012-01-01

The user perspective is an important contextual factor for Supreme Audit Institutions (SAIs). This article provides examples from performance audits in Norway and explores why the user perspective has become important in performance audit practices. It shows that user satisfaction can be employed as a key performance indicator of effectiveness of…

Multiple Approaches to the Validation of the Scores from the Study Anxiety Inventory

ERIC Educational Resources Information Center

Lunsford, George Douglas

2009-01-01

The Study Anxiety Inventory (SAI), consisting of the factors of worry and emotionality, was developed to measure college students' self-reported levels of anxiety while studying for an exam. Data from 2002 undergraduate students from four colleges (Arts and Sciences, Engineering, Business, and Education) at a southeastern state university were…

Cognitive Ability, Self-Assessed Intelligence and Personality: Common Genetic but Independent Environmental Aetiologies

ERIC Educational Resources Information Center

Bratko, Denis; Butkovic, Ana; Vukasovic, Tena; Chamorro-Premuzic, Tomas; von Stumm, Sophie

2012-01-01

Self-perceived abilities (SPA), which play an important role in academic achievement, have been recently reported to be fully attributable to genetic and non-shared environmental influences. To replicate and extend this finding, 732 Croatian twins (15-22 years old) were assessed on cognitive ability, self-assessed intelligence (SAI), and Five…

Some Phenomena on Negative Inversion Constructions

ERIC Educational Resources Information Center

Sung, Tae-Soo

2013-01-01

We examine the characteristics of NDI (negative degree inversion) and its relation with other inversion phenomena such as SVI (subject-verb inversion) and SAI (subject-auxiliary inversion). The negative element in the NDI construction may be" not," a negative adverbial, or a negative verb. In this respect, NDI has similar licensing…

16 CFR 0.20 - Office of International Affairs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... consumer protection aspects of trade fora and negotiations, such as the U.S. inter-agency delegations... international antitrust, international consumer protection, and international technical assistance. OIA is... advice to the Bureaus of Competition and Consumer Protection with regard to the international aspects of...

Mind navigators of chemicals' experimenters? A web-based description of e-psychonauts.

PubMed

Orsolini, Laura; Papanti, Gabriele Duccio; Francesconi, Giulia; Schifano, Fabrizio

2015-05-01

Within online drug fora communities, there are some "educated and informed" users who can somehow provide reliable information on psychoactive compounds and combinations. These users, also called "e-psychonauts," may possess levels of technical knowledge relating to a range of novel psychoactive substances (NPS). The present project aimed at identifying and describing the e-psychonauts' socio-demographic characteristics and their motivations and patterns of drug intake. A netnographic research methodology, carried out through an unobtrusive observational approach of a list of cyber drug communities (blogs, fora, Facebook, and Twitter pages) was carried out. The fora posts and threads were accurately reviewed, analyzed, and compared using the empirical phenomenological psychological (EPP) method. Data were collected between January and February 2014. Psychonauts typically considered themselves as "psychedelic researchers," "new Shamans," "philosophers," or "alchemists." They appeared to be mainly young, males, unmarried, and Caucasians. They presented with good or excellent employment conditions and with a set of key skills, including attention to their inner "soul"; high standards of knowledge about drugs' chemical and pharmacological issues; and high levels of both IT skills and verbal fluency in reporting their own "on drug" experiences. The e-psychonauts seemed to "test" and at times synthesize a range of drugs to achieve the state of consciousness they find most pleasurable. There is the need to improve both the existing levels of professionals' knowledge on this novel generation of drug misusers and to design and develop novel prevention approaches that are able to attract the attention of the e-psychonauts.

Designing a placebo device: involving service users in clinical trial design.

PubMed

Gooberman-Hill, Rachael; Jinks, Clare; Bouças, Sofia Barbosa; Hislop, Kelly; Dziedzic, Krysia S; Rhodes, Carol; Burston, Amanda; Adams, Jo

2013-12-01

Service users are increasingly involved in the design of clinical trials and in product and device development. Service user involvement in placebo development is crucial to a credible and acceptable placebo for clinical trials, but such involvement has not yet been reported. To enhance the design of a future clinical trial of hand splints for thumb-base osteoarthritis (OA), service users were involved in splint selection and design of a placebo splint. This article describes and reflects on this process. Two fora of service users were convened in 2011. Service users who had been prescribed a thumb splint for thumb-base OA were approached about involvement by Occupational Therapy (OT) practitioners. A total of eight service users took part in the fora. Service users discussed their experience of OA and their own splints and then tried a variety of alternative splints. Through this they identified the active features of splints alongside acceptable and unacceptable design features. Service users focused on wearability and support with or without immobilization. Fora discussed whether a placebo group ('arm') was an acceptable feature of a future trial, and service users developed a potential design for a placebo splint. This is the first project that to involve service users in placebo design. Service users are increasingly involved in product and device design and are ideally placed to identify features to make a placebo credible yet lacking key active ingredients. The future trial will include research into its acceptability. © 2013 John Wiley & Sons Ltd.

Sacramento Regional Response Guide to Radiation Emergencies

DTIC Science & Technology

2006-09-01

emergency operations. Additionally, the utilization of thermo luminescence dosimeters ( TLD ) may be beneficial to track long term exposure for...a radiation area. Stakeholder agency emergency response equipment have been issued electronic dosimeters The purpose of the radiation dosimeter is...Incident.............................................................................84 2. Detection/ Dosimeter Equipment

Superconducting dc Current Limiting Vacuum Circuit Breaker

NASA Astrophysics Data System (ADS)

Alferov, D. F.; Akhmetgareev, M. R.; Budovskii, A. I.; Bunin, R. A.; Voloshin, I. F.; Degtyarenko, P. N.; Yevsin, D. V.; Ivanov, V. P.; Sidorov, V. A.; Fisher, L. M.; Tshai, E. V.

Acircuitofadc superconductingfault current limiter witha direct current circuit-breaker fora nominal current 300A is proposed. It includes the 2G high temperature superconducting (HTS) tapes and the high-speed dc vacuum circuit breaker.Thetestresultsof current-limitingcapacityandrecoverytimeof superconductivityafter currentfaultatvoltage upto3 kV are presented.

"The Little Prince"--An Introduction to Spirituality: A Moving Experience in Religious Education for Primary School Children in a Secularised World

ERIC Educational Resources Information Center

ter Avest, Ina; McDougall, Roseanne

2014-01-01

In our research the right of the child for spiritual development is central. Grimmitt's distinction in "teaching in", "about" and "from religion" is extended with the concept of "teaching for"--a concept that connects religion with children's attitude of wondering as an "ontological calling" in…

Coral reef habitats as surrogates of species, ecological functions, and ecosystem services.

PubMed

Mumby, Peter J; Broad, Kenneth; Brumbaugh, Daniel R; Dahlgren, Craig P; Harborne, Alastair R; Hastings, Alan; Holmes, Katherine E; Kappel, Carrie V; Micheli, Fiorenza; Sanchirico, James N

2008-08-01

Habitat maps are often the core spatially consistent data set on which marine reserve networks are designed, but their efficacy as surrogates for species richness and applicability to other conservation measures is poorly understood. Combining an analysis of field survey data, literature review, and expert assessment by a multidisciplinary working group, we examined the degree to which Caribbean coastal habitats provide useful planning information on 4 conservation measures: species richness, the ecological functions of fish species, ecosystem processes, and ecosystem services. Approximately one-quarter to one-third of benthic invertebrate species and fish species (disaggregated by life phase; hereafter fish species) occurred in a single habitat, and Montastraea-dominated forereefs consistently had the highest richness of all species, processes, and services. All 11 habitats were needed to represent all 277 fish species in the seascape, although reducing the conservation target to 95% of species approximately halved the number of habitats required to ensure representation. Species accumulation indices (SAIs) were used to compare the efficacy of surrogates and revealed that fish species were a more appropriate surrogate of benthic species (SAI = 71%) than benthic species were for fishes (SAI = 42%). Species of reef fishes were also distributed more widely across the seascape than invertebrates and therefore their use as a surrogate simultaneously included mangroves, sea grass, and coral reef habitats. Functional classes of fishes served as effective surrogates of fish and benthic species which, given their ease to survey, makes them a particularly useful measure for conservation planning. Ecosystem processes and services exhibited great redundancy among habitats and were ineffective as surrogates of species. Therefore, processes and services in this case were generally unsuitable for a complementarity-based approach to reserve design. In contrast, the representation

Climate engineering and the ocean: effects on biogeochemistry and primary production

NASA Astrophysics Data System (ADS)

Lauvset, Siv K.; Tjiputra, Jerry; Muri, Helene

2017-12-01

Here we use an Earth system model with interactive biogeochemistry to project future ocean biogeochemistry impacts from the large-scale deployment of three different radiation management (RM) climate engineering (also known as geoengineering) methods: stratospheric aerosol injection (SAI), marine sky brightening (MSB), and cirrus cloud thinning (CCT). We apply RM such that the change in radiative forcing in the RCP8.5 emission scenario is reduced to the change in radiative forcing in the RCP4.5 scenario. The resulting global mean sea surface temperatures in the RM experiments are comparable to those in RCP4.5, but there are regional differences. The forcing from MSB, for example, is applied over the oceans, so the cooling of the ocean is in some regions stronger for this method of RM than for the others. Changes in ocean net primary production (NPP) are much more variable, but SAI and MSB give a global decrease comparable to RCP4.5 (˜ 6 % in 2100 relative to 1971-2000), while CCT gives a much smaller global decrease of ˜ 3 %. Depending on the RM methods, the spatially inhomogeneous changes in ocean NPP are related to the simulated spatial change in the NPP drivers (incoming radiation, temperature, availability of nutrients, and phytoplankton biomass) but mostly dominated by the circulation changes. In general, the SAI- and MSB-induced changes are largest in the low latitudes, while the CCT-induced changes tend to be the weakest of the three. The results of this work underscore the complexity of climate impacts on NPP and highlight the fact that changes are driven by an integrated effect of multiple environmental drivers, which all change in different ways. These results stress the uncertain changes to ocean productivity in the future and advocate caution at any deliberate attempt at large-scale perturbation of the Earth system.

The effects of two different doses of hydrocortisone on cognition in patients with secondary adrenal insufficiency--results from a randomized controlled trial.

PubMed

Werumeus Buning, Jorien; Brummelman, Pauline; Koerts, Janneke; Dullaart, Robin P F; van den Berg, Gerrit; van der Klauw, Melanie M; Tucha, Oliver; Wolffenbuttel, Bruce H R; van Beek, André P

2015-05-01

A wide variety in hydrocortisone (HC) substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency (SAI). However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. To examine the effects of a high physiological HC dose in comparison to a low physiological HC dose on cognition. This study was a randomized double blind cross-over study at the University Medical Center Groningen. This study is registered with ClinicalTrials.gov, number NCT01546922. Forty-seven patients (29 males, 18 females; mean [SD] age, 51 [14] years, range 19-73) with SAI participated. Patients randomly received first a low dose of HC (0.2-0.3 mg/kg body weight/day) during 10 weeks followed by a high dose (0.4-0.6 mg/kg body weight/day) for another 10 weeks, or vice versa. HC substitution was given in three divided doses with the highest dose in the morning. Cognitive performance (memory, attention, executive functioning and social cognition) of patients was measured at baseline and after each treatment period using a battery of 12 standardized cognitive tests. The higher dose of HC resulted in significantly higher systemic cortisol exposure for example measured at 1h after first dose ingestion (mean [SD], low dose: 653 [281] nmol/L; high dose: 930 [148] nmol/L; P<0.001). No differences in cognitive performance were found between the two dose regimens. No negative influence on memory, attention, executive functioning and social cognition was observed after 10 weeks of treatment with a higher physiological dose of HC in patients with SAI when compared to a lower dose. Copyright © 2015 Elsevier Ltd. All rights reserved.

Operational Use of the AIRS Total Column Ozone Retrievals Along with the RGB Air Mass Product as Part of the GOES-R Proving Ground

NASA Technical Reports Server (NTRS)

Folmer, Michael; Zavodsky, Bradley; Molthan, Andrew

2012-01-01

The National Oceanic and Atmospheric Administration (NOAA) National Centers for Environmental Prediction (NCEP) Hydrometeorological Prediction Center (HPC) and Ocean Prediction Center (OPC) provide short-term and medium-range forecast guidance of heavy precipitation, strong winds, and other features often associated with mid-latitude cyclones over both land and ocean. As a result, detection of factors that lead to rapid cyclogenesis and high wind events is key to improving forecast skill. One phenomenon that has been identified with these events is the stratospheric intrusion that occurs near tropopause folds. This allows for deep mixing near the top of the atmosphere where dry air high in ozone concentrations and potential vorticity descends (sometimes rapidly) deep into the mid-troposphere. Observations from satellites can aid in detection of these stratospheric air intrusions (SAI) regions. Specifically, multispectral composite imagery assign a variety of satellite spectral bands to the red, green, and blue (RGB) color components of imagery pixels and result in color combinations that can assist in the detection of dry stratospheric air associated with PV advection, which in turn may alert forecasters to the possibility of a rapidly strengthening storm system. Single channel or RGB satellite imagery lacks quantitative information about atmospheric moisture unless the sampled brightness temperatures or other data are converted to estimates of moisture via a retrieval process. Thus, complementary satellite observations are needed to capture a complete picture of a developing storm system. Here, total column ozone retrievals derived from a hyperspectral sounder are used to confirm the extent and magnitude of SAIs. Total ozone is a good proxy for defining locations and intensity of SAIs and has been used in studies evaluating that phenomenon (e.g. Tian et al. 2007, Knox and Schmidt 2005). Steep gradients in values of total ozone seen by satellites have been linked

Team-Based Learning's Effects on Standardized Test Scores and Student Reactions

ERIC Educational Resources Information Center

Ulrich, Deborah L.; Brewer, Tracy; Steele-Johnson, Deborah; Juvina, Ion; Peyton, Elizabeth; Hammond, Crystal

2017-01-01

We examined the effects of team-based learning (TBL) versus traditional and enhanced lecture-based instruction over time (Study 1; N = 532 nursing students) and the psychometric properties of the Team Based Learning Student Assessment Instrument (TBL-SAI), a popular measure of reactions to TBL (Study 2; N = 323 nursing and medical students).…

Resources and Constraints Affecting U.S. Army Activities in Latin America

DTIC Science & Technology

1992-09-01

34 Washington Post, 17 January 1992, p. A12. n 7 Reported in Rick Maze, "Pentagon Persists on Reserve Cuts," Army Times, 30 December 1991, p. 6. 8 As...Security Assistance Agency Room 4B730, The Pentagon Washington, DC 20301 Dr. Riordan Roett SAIS Johns Hopkins University 1740 Massachusetts Avenue Washington

A survey of plasma irregularities as seen by the midlatitude Blackstone SuperDARN radar

NASA Astrophysics Data System (ADS)

Ribeiro, A. J.; Ruohoniemi, J. M.; Baker, J. B. H.; Clausen, L. B. N.; Greenwald, R. A.; Lester, M.

2012-02-01

The Super Dual Auroral Radar Network (SuperDARN) is a chain of HF radars that monitor plasma dynamics in the ionosphere. In recent years, SuperDARN has expanded to midlatitudes in order to provide enhanced coverage during geomagnetically active periods. A new type of backscatter from F region plasma irregularities with low Doppler velocity has been frequently observed on the nightside during quiescent conditions. Using three years of data from the Blackstone, VA radar, we have implemented a method for extracting this new type of backscatter from routine observations. We have statistically characterized the occurrence properties of the Sub Auroral Ionospheric Scatter (SAIS) events, including the latitudinal relationships to the equatorward edge of the auroral oval and the ionospheric projection of the plasmapause. We find that the backscatter is confined to local night, occurs on ≈70% of nights, is fixed in geomagnetic latitude, and is equatorward of both the auroral region and the plasmapause boundary. We conclude that SAIS irregularities are observed within a range of latitudes that is conjugate to the inner magnetosphere (plasmasphere).

The Early Bird… Catches the Science Bug!

ERIC Educational Resources Information Center

Pathmanathan, Sai

2015-01-01

Sai Pathmanathan writes in this article that, over the years, her experience working with early-years children (ages 3-5) has taught her that learning it is not about whether the children get the answer right, but more about nurturing their curiosity, encouraging play and learning through hands-on activities, promoting motor skills, group work,…

Engaging US Business in Support of National Security Objectives Task Group Report

DTIC Science & Technology

2008-01-16

meetings of the Business Round Table, the U.S. Chamber of Commerce , and the National Association of REPORT FY08-1 2 Defense Business Board...Round Table, the U.S. Chamber of Commerce , and the National Association of Manufacturers are representative high-level fora where such dialogue would

Online Deliberation among Regional Civil Society Groups--The Case of the Caribbean

ERIC Educational Resources Information Center

Thakur, Dhanaraj G.

2010-01-01

Deliberative democracy has been promoted as a way improving legitimacy and political equality in policy debates. This dissertation seeks to understand how deliberation takes place within the intersection of two unique spaces: dialogue among members of regional civil society groups and communication in online fora. The motivation for this research…

Magic Mountains and multi-disciplines in international medical mobilities Comment on "Patient mobility in the global marketplace: a multidisciplinary perspective".

PubMed

Mainil, Tomas; Meulemans, Herman

2014-06-01

Medical mobilities offer both opportunities and challenges. This tension follows the same ratio as many other historic fora, but offers at the same time a sustainable equilibrium. Multi-disciplines are, therefore, the key to the medical lifeworld for the global health and well-being of transnational health users around the globe.

Is This the Past? The Place of Role-Play Exercises in Undergraduate History Teaching

ERIC Educational Resources Information Center

Beidatsch, Cedric; Broomhall, Susan

2010-01-01

Increasingly, academic teachers are exploring the learning opportunities offered by student-centred participatory classroom and web-supported exercises. Role-play and gaming activities have been highlighted as fora which provide development of a range of personal and social skill sets in students, as well as understanding of subject content. This…

77 FR 49024 - Sai Wentum, M.D.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... in lieu of a hearing and issue this Decision and Final Order based on relevant evidence contained in..., the Show Cause Order alleged that Registrant is currently unlicensed to practice medicine and without...

Immunoregulation.

DTIC Science & Technology

1981-05-01

variety of antigens, KLH, GAT, TGAL and antigens from pathogenic bacteria such as Streptococcus mutans . Furthermore, we now have these systems...histocompatibility complex; PBL, peripheral blood lymphocytes; SAI/II, Streptococcus mutans antigen I/II complex; MHFSAI/II, monkey helper factor specific...from Streptococcus mutans . Helper activity was removed from supernatants of monkey cells by affinity chromatography on Sepharose 4B insolubilized

High-Explosive Cratering a Frozen and Unfrozen Soils in Alaska

DTIC Science & Technology

1980-02-01

SAMPLES I DEPTH TO .... T 24 DATE HOLEIROUN - S]T AR ED adO~ ________ F __24_ad_2____________7 EL . ITHOE (4IQ1 ~.0oioy Section ChlofRrndotboelI a...MotorIoI. Bronco Dno 20 f t.D. FREDRICKSON DEPTH %WATER SAI.IPLE SOIL MAAX FEET .4CtENT NO LEGEND CLASSIFICATION IZE F G i Silty Sandy Gravel Brown, Frozen

Magic Mountains and multi-disciplines in international medical mobilities Comment on "Patient mobility in the global marketplace: a multidisciplinary perspective"

PubMed Central

Mainil, Tomas; Meulemans, Herman

2014-01-01

Medical mobilities offer both opportunities and challenges. This tension follows the same ratio as many other historic fora, but offers at the same time a sustainable equilibrium. Multi-disciplines are, therefore, the key to the medical lifeworld for the global health and well-being of transnational health users around the globe. PMID:24987724

Solar Geoengineering and the Modulation of North Atlantic Tropical Cyclone Frequency

NASA Astrophysics Data System (ADS)

Jones, A. C.; Haywood, J. M.; Hawcroft, M.; Jones, A.; Dunstone, N. J.; Hodges, K.

2017-12-01

Solar geoengineering (SG) refers to a wide range of proposed methods for counteracting global warming by artificially reducing solar insolation at Earth's surface. The most widely known SG proposal is stratospheric aerosol injection (SAI) which has impacts analogous to those from large-scale volcanic eruptions. Observations following major volcanic eruptions indicate that aerosol enhancements confined to a single hemisphere effectively modulate North Atlantic tropical cyclone (TC) activity in the following years. Here we investigate the effects of both single-hemisphere and global SAI scenarios on North Atlantic TC activity using the HadGEM2-ES general circulation model (GCM). We show that a 5 Tg y-1 injection of sulphur dioxide (SO2) into the northern hemisphere (NH) stratosphere would produce a global-mean cooling of 1 K and simultaneously reduce TC activity (to 8 TCs y-1), while the same injection in the southern hemisphere (SH) would enhance TC activity (to 14 TCs y-1), relative to a recent historical period (1950-2000, 10 TCs y-1). Our results reemphasize the risks of regional geoengineering and should motivate policymakers to regulate large-scale unilateral geoengineering deployments.

The Exotic Pest Plant Council

Treesearch

Brian Bowen

1998-01-01

The Exotic Pest Plant Council (EPPC) is a proactive organization established to raise awareness about the threat posed by invasive exotic pest plants in natural areas and acts to stop the continued spread of invasive species. EPPC provides fora for sharing information and provides networking opportunities regarding all matters concerning this issue. EPPC was first...

Genetic management of plants in the California state parks: A primer

Treesearch

Deborah L. Rogers; Connie (editor) Millar

1992-01-01

Conservation biology, of which genetics is a major component, is receiving unprecedented attention in the management of natural resources. National fora on biological diversity, adoption by the World Bank of a strong wildland policy, and creation of new management strategies for species protection in our national parks all attest to the growing acceptance and...

Defense Attache Saigon: RVNAF Quarterly Assessment, 3rd Quarter FY74.

DTIC Science & Technology

1974-05-01

1,600 * Includes one SAiK Regiment ** Includes 12.7, 14.5, 23, 37, 40, 57, 85, and 100MM weapons. 7. (S) ENEM 1Y THREAT AND INTENTIONS BY REGION: a. DAO...there is validity in field reporting, the kill ratio between RF/P? units and enem .’ forces has been running more than 3 to i in favor of the RF/F. g

MN112: a new Galactic candidate luminous blue variable

NASA Astrophysics Data System (ADS)

Gvaramadze, V. V.; Kniazev, A. Y.; Fabrika, S.; Sholukhova, O.; Berdnikov, L. N.; Cherepashchuk, A. M.; Zharova, A. V.

2010-06-01

We report the discovery of a new Galactic candidate luminous blue variable (cLBV) via detection of an infrared circular nebula and follow-up spectroscopy of its central star. The nebula, MN112, is one of many dozens of circular nebulae detected at 24μm in the Spitzer Space Telescope archival data, whose morphology is similar to that of nebulae associated with known (c)LBVs and related evolved massive stars. Specifically, the core-halo morphology of MN112 bears a striking resemblance to the circumstellar nebula associated with the Galactic cLBV GAL079.29+00.46, which suggests that both nebulae might have a similar origin and that the central star of MN112 is an LBV. The spectroscopy of the central star showed that its spectrum is almost identical to that of the bona fide LBV PCygni, which also supports the LBV classification of the object. To further constrain the nature of MN112, we searched for signatures of possible high-amplitude (>~1mag) photometric variability of the central star using archival and newly obtained photometric data covering a 45-yr period. We found that the B magnitude of the star was constant within error margins, while in the I band the star brightened by ~=0.4mag during the last 17 yr. Although the non-detection of large photometric variability leads us to use the prefix `candidate' in the classification of MN112, we remind the readers that the long-term photometric stability is not unusual for genuine LBVs and that the brightness of PCygni remained relatively stable during the last three centuries. Partially based on observations collected at the German-Spanish Astronomical Center, Calar Alto, jointly operated by the Max-Planck-Institut für Astronomie Heidelberg and the Instituto de Astrofísica de Andalucía (CSIC). E-mail: vgvaram@mx.iki.rssi.ru (VVG); akniazev@saao.ac.za (AYK); fabrika@sao.ru (SF); olga@sao.ru (OS); berdnik@sai.msu.ru (LNB); cher@sai.msu.ru (AMC); alla@sai.msu.ru (AVZ)

The Improvement of the Learning Process of Basic Disciplines at the Engineering Design.

ERIC Educational Resources Information Center

de Oliveira, Vanderli Fava; Borges, Marcos Martins; Naveiro, Ricardo Manfredi

The goal of this paper is to reflect upon Engineering Education, starting from experiments that have been carried out at the Federal University of Juiz de Fora (UFJF), aiming to improve the learning process of the content of basic drawing disciplines concerned with graphic representation, which are subjects of the initial terms of the courses of…

Standards-Based Assessments in the Classroom: A Feasible Approach to Improving the Quality of Students' Learning

ERIC Educational Resources Information Center

Sharma, Priyanka

2015-01-01

In the new millennium, the Indian education system has experienced a major shift and the issue of the quality of education has taken centre stage in policy discussion fora. Globally, assessment has become an important means of improving the quality of education, both at the systemic level and at the level of individual students. It necessitates…

Letters

NASA Astrophysics Data System (ADS)

2008-07-01

Confused or incorrect? J Khan Reply to the above letter from the authors of 'Aerodynamics experiments with an observable airflow: a fog-wind-tunnel' B Priemer A misleading explanation H Fricker Reply to the above letter from the authors of 'Demonstrate Lenz's law with an aluminium ring' Lyna, C T Chee, C L Sai, G N Khang and T A Ling The heart of the problem B Marshall

Phase Equilibria and Transition in Mixtures of a Homopolymer and a Block Copolymer. I. Small-Angle X-Ray Scattering Study.

DTIC Science & Technology

1983-03-08

tlh repow ) !Unclassified lie. DECLASSI FICATION/ DOWNGRADING SCHEDULE 16. DISTRIBUTION STATEMENT ( of this Report) Distribution Unlimited, Approved for...a block copolymer can sometimes be transformed into a homogeneous, disordered structure. The tem- perature of the transition depends on the degree of ...probably that the morphology is gradually transformed from spherical to cylindrical and eventually to lamellar packing. There is, however, no evidence of

Facilitators' Challenges and Critical Success Factors in Working with SAI Groups.

ERIC Educational Resources Information Center

Festeu, Dorin

2002-01-01

A summer program at Ambleside (England) works with adolescents who are at risk of becoming disaffected with life. Challenging outdoor activities increase students' self-esteem and keep them in contact with education, training, or employment. Good facilities and a pleasant environment can contribute to meeting objectives, but facilitators'…

Quantitative adaptation analytics for assessing dynamic systems of systems: LDRD Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gauthier, John H.; Miner, Nadine E.; Wilson, Michael L.

2015-01-01

Our society is increasingly reliant on systems and interoperating collections of systems, known as systems of systems (SoS). These SoS are often subject to changing missions (e.g., nation- building, arms-control treaties), threats (e.g., asymmetric warfare, terrorism), natural environments (e.g., climate, weather, natural disasters) and budgets. How well can SoS adapt to these types of dynamic conditions? This report details the results of a three year Laboratory Directed Research and Development (LDRD) project aimed at developing metrics and methodologies for quantifying the adaptability of systems and SoS. Work products include: derivation of a set of adaptability metrics, a method for combiningmore » the metrics into a system of systems adaptability index (SoSAI) used to compare adaptability of SoS designs, development of a prototype dynamic SoS (proto-dSoS) simulation environment which provides the ability to investigate the validity of the adaptability metric set, and two test cases that evaluate the usefulness of a subset of the adaptability metrics and SoSAI for distinguishing good from poor adaptability in a SoS. Intellectual property results include three patents pending: A Method For Quantifying Relative System Adaptability, Method for Evaluating System Performance, and A Method for Determining Systems Re-Tasking.« less

A better way of representing stem area index in two-big-leaf models: the application and impact on canopy integration of leaf nitrogen content

NASA Astrophysics Data System (ADS)

Chen, M.; Butler, E. E.; Wythers, K. R.; Kattge, J.; Ricciuto, D. M.; Thornton, P. E.; Atkin, O. K.; Flores-Moreno, H.; Reich, P. B.

2017-12-01

In order to better estimate the carbon budget of the globe, accurately simulating gross primary productivity (GPP) in earth system models is critical. When upscaling leaf level photosynthesis to the canopy, climate models uses different big-leaf schemes. About half of the state-of-the-art earth system models use a "two-big-leaf" scheme that partitions canopies into direct and diffusively illuminated fractions to reduce high bias of GPP simulated by one-big-leaf models. Some two-big-leaf models, such as ACME (identical in this respect to CLM 4.5) add leaf area index (LAI) and stem area index (SAI) together when calculating canopy radiation transfer. This treatment, however, will result in higher fraction of sunlit leaves. It will also lead to an artificial overestimation of canopy nitrogen content. Here we introduce a new algorithm of simulating SAI in a two-big-leaf model. The new algorithm reduced the sunlit leave fraction of the canopy and conserved the nitrogen content from leaf to canopy level. The lower fraction of sunlit leaves reduced global GPP especially in tropical area. Compared to the default model, for the past 100 years (1909-2009), the averaged global annual GPP is lowered by 4.11 PgC year-1 using this new algorithm.

Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled Trial.

PubMed

Nejati, Parisa; Ghahremaninia, Armita; Naderi, Farrokh; Gharibzadeh, Safoora; Mazaherinezhad, Ali

2017-05-01

Subacromial impingement syndrome (SAIS) is the most common disorder of the shoulder. The evidence for the effectiveness of treatment options is inconclusive and limited. Therefore, there is a need for more evidence in this regard, particularly for long-term outcomes. Platelet-rich plasma (PRP) would be an effective method in treating subacromial impingement. Randomized controlled trial; Level of evidence, 1. This was a single-blinded randomized clinical trial with 1-, 3-, and 6-month follow-up. Sixty-two patients were randomly placed into 2 groups, receiving either PRP or exercise therapy. The outcome parameters were pain, shoulder range of motion (ROM), muscle force, functionality, and magnetic resonance imaging findings. Both treatment options significantly reduced pain and increased shoulder ROM compared with baseline measurements. Both treatments also significantly improved functionality. However, the treatment choices were not significantly effective in improving muscle force. Trend analysis revealed that in the first and third months, exercise therapy was superior to PRP in pain, shoulder flexion and abduction, and functionality. However, in the sixth month, only shoulder abduction and total Western Ontario Rotator Cuff score were significantly different between the 2 groups. Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective.

Food consumed outside the home in Brazil according to places of purchase.

PubMed

Bezerra, Ilana Nogueira; Moreira, Tyciane Maria Vieira; Cavalcante, Jessica Brito; Souza, Amanda de Moura; Sichieri, Rosely

2017-03-23

This study aims to describe the places of purchase of food consumed outside the home, characterize consumers according to the places of consumption, and identify the food purchased by place of consumption in Brazil. We have used data from the Pesquisa de Orçamento Familiar (Household Budget Survey) of 2008-2009 with a sample of 152,895 subjects over 10 years of age. The purchase of food outside the home was collected from the records of all expenditures made in seven days. The places of purchase were grouped according to their characteristics: supermarket, bakery, street food, restaurant, snack bar, fruit shop, and other places. The types of food were grouped into nine categories, considering the nutritional aspects and the marketing characteristics of the item. We have estimated the frequency of purchase in the seven groups of places in Brazil and according to gender and type of food purchased per place. We have calculated the average age, income and years of education, as well as the per capita expenditure according to places of purchase of food consumed outside the home. The purchase of food outside the home was reported by 41.2% of the subjects, being it greater among men than women (44% versus 38.5%). Adults had a higher frequency (46%) than teenagers (37.7%) and older adults (24.2%). The highest frequency of places of purchase were snack bar (16.9%) and restaurant (16.4%), while the fruit shop (1.2%) presented the lowest frequency. Sweets, snack chips and soft drinks were the most purchased items in most places. Average expenditure was higher for restaurant (R$33.20) and lower for fruit shop (R$4.10) and street food (R$5.00). The highest percentage of food consumed outside the home comes from snack bars and restaurants, pointing to important places for the development of public policies focused on promoting healthy eating. Descrever os locais de aquisição dos alimentos consumidos fora do lar, caracterizar os consumidores de acordo com os locais de consumo

Comparative Study of Four Membranes for Evaluation of New Insect/Arthropod Repellents Using Aedes aegypti

DTIC Science & Technology

2008-01-01

market and had no plans to continuously provide the membranes. Thus, in an effort to find an alternative iu t•itro membrane test system, our initial...Professional: R Chandra Sekhar Junior SponsoriDg Editor: Nimisha Gorwami Manager-sales & Marketing : S Girish Controller-Production: Rajender P Ghansela...DDA Market , Paschim Vihar, New Delhi 110 063, and printed at Sai Printo Pack Pvt. Ltd., A-102/4, Okhla Industrial Area, Phase II. New Delhi 110 020

Broadband anomalous reflection caused by unsymmetrical specific acoustic impedance in phononic crystals

NASA Astrophysics Data System (ADS)

Han, S. K.; Wu, C. W.; Chen, Z.

2018-01-01

We investigate through numerical simulation the anomalous reflection (AR) of acoustic waves with perfect phononic crystals (PCs). Broadband AR is observed in a wide angle for the oblique incidence. The AR is due to the unsymmetrical specific acoustic impedance (SAI) profile along the surface, which is caused by the high frequency incidence. The findings in this paper complement the theories for the AR of acoustic waves with PCs, and may find applications in acoustic engineerings.

Drug Abuse Prevention. Further Efforts Needed to Identify Programs that Work.

DTIC Science & Technology

1987-12-01

Depart- ment of Education, the Office of Substance Abuse Prevention within HHS, and AMTON were the primary beneficiaries of the increased federal effort... Abuse ( SAi Office of Substance Abuse and Prevention VISTA Volunteers in Service to America Page 8 GAO’ HRDN-W26 Drug Abuse Preven tion Programs...osAP held a national strategy conference attended by substance abuse prevention experts who provided guidance and recom- mendations to help osAP refine

Britain, France and Germany: Priorities for the European Union’s Security and Defense Policy

DTIC Science & Technology

2009-12-01

Ronja Kempin and Marco Overhaus, Kein großer Sprung in der Entwicklung der ESVP: Lehren aus der Französischen EU- Ratspräsidentschaft (Berlin...Power," Survival 37, no. 3 (Autumn 1995), 82–103, 96. 144 Marco Overhaus, "German Foreign Policy and the Shadow of the Past," SAIS Review 25, no. 2...have enforced an arms embargo, Marco Overhaus, a research fellow at the German 171 Thomas

Advanced Space Propulsion Study - Antiproton and Beamed Power Propulsion

DTIC Science & Technology

1987-10-01

of the Earth . 2 Fp F 7200 km OFFSET " 1 8OQL# SUNLIGHT DURING FT O SAI -EQUINOX% LEVITATED ORBIT 106 .~ SALk 6,600 kr% I ii - -- - " 6 ELEVATIONS... Plasma Physics, 3-7 Nov 1986, Baltimore, Maryland. 26. G. Vulpetti and E. Pieragostini, "Matter-Antimatter Annihilation Engine Design Concept for Earth ...have the potential of attaining higher specific impulse than engines limited by the thermal properties of matter. Analysis of plasma transport

A Simple, Low Overhead Data Compression Algorithm for Converting Lossy Compression Processes to Lossless

DTIC Science & Technology

1993-12-01

0~0 S* NAVAL POSTGRADUATE SCHOOL Monterey, California DTIC ELECTE THESIS S APR 11 1994DU A SIMPLE, LOW OVERHEAD DATA COMPRESSION ALGORITHM FOR...A SIMPLE. LOW OVERHEAD DATA COMPRESSION ALGORITHM FOR CONVERTING LOSSY COMPRESSION PROCESSES TO LOSSLESS. 6. AUTHOR(S) Abbott, Walter D., III 7...Approved for public release; distribution is unlimited. A Simple, Low Overhead Data Compression Algorithm for Converting Lossy Processes to Lossless by

Strategic Role of Sri Lankan Tamil Diaspora in Promoting Separatism in Sri Lanka

DTIC Science & Technology

2014-06-13

Tamil Eelam and the Tamil genocide in Sri Lanka. This campaign tries to achieve its objectives through the boycott of Sri Lankan tourism and products...Lanka campaign.157 The boycott Sri Lanka campaign is not limited to tourism or products. The Tamil Youth Organization (TYO) is conducting a “Boycott...Sri Lankan sports are not accepted in international fora as they 155Tamils Against Genocide

Topography and Higher Order Corneal Aberrations of the Fellow Eye in Unilateral Keratoconus.

PubMed

Aksoy, Sibel; Akkaya, Sezen; Özkurt, Yelda; Kurna, Sevda; Açıkalın, Banu; Şengör, Tomris

2017-10-01

Comparison of topography and corneal higher order aberrations (HOA) data of fellow normal eyes of unilateral keratoconus patients with keratoconus eyes and control group. The records of 196 patients with keratoconus were reviewed. Twenty patients were identified as unilateral keratoconus. The best corrected visual acuity (BCVA), topography and aberration data of the unilateral keratoconus patients' normal eyes were compared with their contralateral keratoconus eyes and with control group eyes. For statistical analysis, flat and steep keratometry values, average corneal power, cylindrical power, surface regularity index (SRI), surface asymmetry index (SAI), inferior-superior ratio (I-S), keratoconus prediction index, and elevation-depression power (EDP) and diameter (EDD) topography indices were selected. Mean age of the unilateral keratoconus patients was 26.05±4.73 years and that of the control group was 23.6±8.53 years (p>0.05). There was no statistical difference in BCVA between normal and control eyes (p=0.108), whereas BCVA values were significantly lower in eyes with keratoconus (p=0.001). Comparison of quantitative topographic indices between the groups showed that all indices except the I-S ratio were significantly higher in the normal group than in the control group (p<0.05). The most obvious differences were in the SRI, SAI, EDP, and EDD values. All topographic indices were higher in the keratoconus eyes compared to the normal fellow eyes. There was no difference between normal eyes and the control group in terms of spherical aberration, while coma, trefoil, irregular astigmatism, and total HOA values were higher in the normal eyes of unilateral keratoconus patients (p<0.05). All HOA values were higher in keratoconus eyes than in the control group. According to our study, SRI, SAI, EDP, EDD values, and HOA other than spherical aberration were higher in the clinically and topographically normal fellow eyes of unilateral keratoconus patients when compared

Living in a material world: Development and evaluation of a new materials science course for non-science majors

NASA Astrophysics Data System (ADS)

Brust, Gregory John

This study was designed to discover if there is a difference in the scientific attitudes and process skills between a group of students who were instructed with Living in a Material World and groups of students in non-science majors sections of introductory biology, chemistry, and geology courses at the University of Southern Mississippi (USM). Each of the four courses utilized different instructional techniques. Students' scientific attitudes were measured with the Scientific Attitudes Inventory (SAI II) and their knowledge of science process skills were measured with the Test of Integrated Process Skills (TIPS II). The Group Assessment of Logical Thinking (GALT) was also administered to determine if the cognitive levels of students are comparable. A series of four questionnaires called Qualitative Course Assessments (QCA) were also administered to students in the experimental course to evaluate subtle changes in their understanding of the nature and processes of science and attitudes towards science. Student responses to the QCA questionnaires were triangulated with results of the qualitative instruments, and students' work on the final project. Results of the GALT found a significant difference in the cognitive levels of students in the experimental course (PSC 190) and in one of the control group, the introductory biology (BSC 107). Results of the SAI II and the TIPS II found no significant difference between the experimental group and the control groups. Qualitative analyses of students' responses to selected questions from the TIPS II, selected items on the SAI II, QCA questionnaires, and Materials that Fly project reports demonstrate an improvement in the understanding of the nature and processes of science and a change to positive attitude toward science of students in the experimental group. Students indicated that hands-on, inquiry-based labs and performance assessment were the most effective methods for their learning. These results indicate that science

National Training Center (NTC) Analysis

DTIC Science & Technology

1981-05-29

CONTRACT FOR S100K NTC CONCEPT STUDY PRESENTATION TO DARPA/TRADOC SIOOK ADD- ON FOR FURTHER NTC CONCEPT DEVELOPMENT SAI CONCEPT FOR 1-ALPHA...Technical Report 29 May 1981 I I I This document is submitted in fulfillment of contract No. DAAK 40-78-C-0198. It is the final report on Phase 1...many technical reports have been published previously. This report draws on these earlier reports and presents a comprehensive summary and overview

Anthropomorphic Phantom Radiation Dosimetry at the NATO Standard Reference Point at Aberdeen Proving Ground,

DTIC Science & Technology

1987-04-01

and would still be well under 10(C. .% % p., I V a- E p - -12 - IABLE 8 (a) TLD results for phantom dosimetry - all values shown are measured charge...SAI. Conclusions The current DREO dosimetry system-consisting of bubble, CR39 and TLD dosimeters - has proven capable of producing meaningful results at...MC FILE CoPy’ Defence nationale 00 ANTHROPOMORPHIC PHANTOM RADIATION DOSIMETRY AT THE NATO STANDARD OREFERENCE POINT AT ABERDEEN PROVING GROUND by T

Southeast Asia Report.

DTIC Science & Technology

1987-04-23

11 DAP Ready To Talk With MCA, Gerakan (SIN CHEW JIT POH MALAYSIA, 17 Feb 87) 13 - a - Rahman, Taib Rivalry Examined (Shah A. Dadameah; THE STAR...bank, MCA Deputy President Datuk Lee Kim Sai disclosed that this problem has been resolved. 9300/12232 CSO: 4205/12 12 MALAYSIA DAP READY TO... DAP ], today stressed that in the common interests of ethnic Chinese citizens, his party is ever-ready to hold a dialogue with the Malaysian Chinese

Observer Based Compensators for Nonlinear Systems

DTIC Science & Technology

1989-03-31

T’niversitV of California I_ ______ Air Force Office Of Scientific RPesprc~i 6c. ADDI ESS ( C ..ty. State, ania ZIP Code) 7b. ADDRESS (City, State, and Z...Mathematics, M. Luksik, C . Martin and W. Shadwick, eds. Contempary Mathematics V.68, American Mathematical Society, Providence, 157-189. 2. 1987 Krener, A...ibution I University of California C AvJility Codes Avail ,111d I of Davis, CA 95616 sai. spvc-d TABLE OF CONTENTS A bstract

Security Assistance, Surrogate Armies, and the Pursuit of US Interests in Sub-Saharan Africa

DTIC Science & Technology

2010-01-01

155 N. Twining Street, Building 693, Maxwell AFB ,AL,36112-6026 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND...Herman J . Cohen, “US-Africa Policy as Conflict Management,” SAIS Review 21, no. 1 (Winter–Spring 2001): 241–42. 8. For example, see Björn Hallberg...The version endorsed by the UNSC with the additional restrictions on participation was approved by the AU PSC in September 2006. See Cecilia Hull

E-Area LLWF Vadose Zone Model: Probabilistic Model for Estimating Subsided-Area Infiltration Rates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dyer, J.; Flach, G.

A probabilistic model employing a Monte Carlo sampling technique was developed in Python to generate statistical distributions of the upslope-intact-area to subsided-area ratio (Area UAi/Area SAi) for closure cap subsidence scenarios that differ in assumed percent subsidence and the total number of intact plus subsided compartments. The plan is to use this model as a component in the probabilistic system model for the E-Area Performance Assessment (PA), contributing uncertainty in infiltration estimates.

Materials for High-Density Electronic Packaging and Interconnection

DTIC Science & Technology

1990-04-10

play a prominent role in the future. Glass and Porcelain The earliest use of electronic ceramics was as insulators for carrying telegraph lines...Administration 61L & CORES , (Ot. stem. SAI WCJm 76. LOISS (C". SUMt *oW WVCf B’%2101 Constitution Avenue. N W Washington, D.C. 20418 Washington. D.C. 20301 G...Density Packaging 84 Tape Automated Bonding 87 Diamond 88 Superconductors 88 Composites 89 Materials for Very-High-Frequency Digital Systems 91

VizieR Online Data Catalog: AI CMi UBV light curves (Arkhipova+, 2017)

NASA Astrophysics Data System (ADS)

Arkhipova, V. P.; Ikonnikova, N. P.; Esipov, V. F.; Komissarova, G. V.

2017-07-01

The UBV observations of AI CMi were carried out at the Crimean Station of the SAI MSU using a 60-cm Zeiss reflector with a photoelectric photometer designed by Lyuty (1971, Soobshch. GAISh, No. 172, 30) with a 27" aperture. We began to observe AI CMi in 1996 and obtained more than 200 UBV magnitude estimates for the star in 21 years. Table 1 presents our UBV photometry for AI CMi reduced to the Johnson system. (1 data file).

Laser-Induced Breakdown Spectroscopy for Detection of Explosives Residues: A Review of Recent Advances, Challenges, and Future Prospects

DTIC Science & Technology

2013-04-01

for discrimination [14, 15, 17]. Both Anzano et al . [18] and Tran et al . [21] analyzed the emission intensity ratios of several organic compounds for...A PC displays and ana- lyzes the recorded spectra, which are characteristic of the target material 284 J.L. Gottfried et al . The successful detection...energetic organic compounds 286 J.L. Gottfried et al . and experimental configuration. Several theoretical models have recently been developed to

The Role of Social Media in Crisis

DTIC Science & Technology

2012-06-01

affected regions to be shared with rescue organizations. • Members of social networking sites , such as Twitter and Facebook, spread messages and pleas...internet sites such as blogs, wikis, fora and community journalism. • The authorities monitored local and network news broadcasts, as well as internet...established a dedicated force to monitor and respond to them. Best Paper Award Paper 007: The Role of Social Media in Crisis Lessons From Past

Strength Training Does Not Affect Vagal-cardiac Control or Cardiovagal Baroreflex Sensitivity in Young Healthy Subjects

DTIC Science & Technology

2005-03-01

shown to help control or lower arterial blood pressure (Carter JR et al. 2003; Kelley and Kelley 2000), and has been recommended as therapy for...as determined by a physician during a routine physical examination. The experimental protocol was approved by the Human Research Committee of Michigan...car diovagal and sympathetic responses to Valsalva’s maneuver. Med Sci Sports Exerc 34:928 935 Ekblom B, Kilbom ASA, Soltysiak J (1973) Physical

Whole of Government Approach to Transnational Organized Crime: Where and How Does the Military Fit In?

DTIC Science & Technology

2015-06-12

justice. The below articles of Title VII address the issues involved in combatting crime: 49 ARTICLE 89 Money laundering and financing of...mechanisms to combat money laundering and financing of terrorism equivalent to those adopted by the EU and other international fora in this field, in...tools to recover assets stolen by corrupt officials and make it harder for criminals to hide, launder , and benefit from illegal proceeds. Our

Shape Memory Actuator System

DTIC Science & Technology

1998-07-31

The advantage in utilizing 15 shape-memory cables made of Nitinol for size reduction of the remote control actuator system is 1 Fi well suited for...a submarine environment because of its non-magnetic and corrosion resistance 17 properties. Use of thermoelastic Nitinol introduces other...problems because of the cooling and 18 resetting properties of Nitinol cables. It is therefore an important object of the present invention 19 on to

Malaria in tree crop plantations in south-eastern and western provinces of Thailand.

PubMed

Singhasivanon, P; Thimasarn, K; Yimsamran, S; Linthicum, K; Nualchawee, K; Dawreang, D; Kongrod, S; Premmanisakul, N; Maneeboonyang, W; Salazar, N

1999-09-01

During the past three decades almost half of the existing natural tropical forests in Thailand were destroyed and replaced by cash crops, rubber, coffee, fruit orchards (durian, rambutan, mangosteen) and other commercial plantations. In order to determine the proportion of malaria cases contracted from such commercial plantations, an epidemiological study was conducted between June 1996 to May 1997 in two districts, one in Pong Nam Ron, located in a south-eastern province near the Cambodian border and another in Sai Yok, in a western province along the Myanmar border. Data were collected by passive case detection from patients attending the existing malaria clinics and active case detection by monthly malariometric survey in selected villages. All malaria cases were thoroughly investigated and classified according to exposure to different ecotypes prior to onset of malaria symptoms in the preceding two weeks. Malaria cases acquired from commercial plantations accounted for 35.2% and 11.2% in Pong Nam Ron and in Sai Yok districts respectively. In such plantations, most of the malaria cases were contracted from fruit orchards and to a lesser extent from rubber and teak plantations. From this study it is evident that commercial plantations provide a significant site of malaria transmission in addition to the forest and foothills areas in Southeast Asia where efficient vectors such as An. dirus and An. minimus are prevalent and have adapted to such changed ecosystems.

Bat assemblages from three Atlantic Forest fragments in Rio de Janeiro state, Southeastern Brazil

PubMed Central

Rosa, Daniel Tavares Cassilhas; Vrcibradic, Davor; Avilla, Leonardo dos Santos

2015-01-01

Abstract Bat species richness in Neotropical localities is generally higher than that of any other group of mammals, and surveys of local bat assemblages may provide useful data for conservation management plans. Although the bat fauna of the Rio de Janeiro state is currently one of the best known in Brazil, there are several localities not adequately surveyed yet, and most of them are in the mountainous regions and in the northern portion of the state. From January 2008 to November 2009, we conducted surveys of bats in three localities in the state of Rio de Janeiro (municipalities of Varre-Sai, Sumidouro, and Cantagalo), and our fieldwork constitutes the first assessment of the bat assemblages of these localities. Surveys were conducted using mist nets in four different habitat types in each locality (forest interior, forest edge, riparian forest, and open areas [pastures]). We captured a total of 148 individuals in 17 species, 14 genera and 3 families. Among them, 11 species were recorded in Sumidouro, seven in Cantagalo, and nine in Varre-Sai. Although species richness was low compared with previous surveys in other close localities, we recorded species that have been rarely sampled in Southeastern Brazil (e.g., Macrophyllum macrophyllum [Phyllostomidae]). The results reinforce the importance of sampling different habitats in short surveys to improve the number of species registered. PMID:25632263

Treatment of Subacromial Impingement Syndrome: Platelet-Rich Plasma or Exercise Therapy? A Randomized Controlled Trial

PubMed Central

Nejati, Parisa; Ghahremaninia, Armita; Naderi, Farrokh; Gharibzadeh, Safoora; Mazaherinezhad, Ali

2017-01-01

Background: Subacromial impingement syndrome (SAIS) is the most common disorder of the shoulder. The evidence for the effectiveness of treatment options is inconclusive and limited. Therefore, there is a need for more evidence in this regard, particularly for long-term outcomes. Hypothesis: Platelet-rich plasma (PRP) would be an effective method in treating subacromial impingement. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a single-blinded randomized clinical trial with 1-, 3-, and 6-month follow-up. Sixty-two patients were randomly placed into 2 groups, receiving either PRP or exercise therapy. The outcome parameters were pain, shoulder range of motion (ROM), muscle force, functionality, and magnetic resonance imaging findings. Results: Both treatment options significantly reduced pain and increased shoulder ROM compared with baseline measurements. Both treatments also significantly improved functionality. However, the treatment choices were not significantly effective in improving muscle force. Trend analysis revealed that in the first and third months, exercise therapy was superior to PRP in pain, shoulder flexion and abduction, and functionality. However, in the sixth month, only shoulder abduction and total Western Ontario Rotator Cuff score were significantly different between the 2 groups. Conclusion: Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective. PMID:28567426

Insight and satisfaction with life among adolescents with mental disorders: assessing associations with self-stigma and parental insight.

PubMed

Gaziel, M; Hasson-Ohayon, I; Morag-Yaffe, M; Schapir, L; Zalsman, G; Shoval, G

2015-02-01

The purpose of the current study was to assess the associations of illness perception-related variables with satisfaction with life (SwL) among adolescents with mental disorders. Insight into mental disorder (SAI-E), Internalized stigma of mental illness (ISMI) and Multidimensional Students' Life Satisfaction Scale (MSLSS) were administrated to 30 adolescent patients. Adapted version for parents of the SAI-E was also administrated to 37 of their parents. Significant positive correlations were found between insight into the illness, self-stigma and parental insight. Insight and self-stigma were significantly negatively related to the total score of SwL and few of its dimensions while parental insight was significantly associated only with the SwL dimensions of school and self. Regression models revealed main negative effects of insight and self-stigma on SwL and no interaction effect. The possible independent contribution of insight and self-stigma to SwL should be addressed in interventions designed for family and adolescents coping with mental illness. Special attention should be given to the possible negative implications that insight possesses. In lack of support of the moderation role of self-stigma, reported in studies among adults with mental illness, future studies should trace other variables in order to further understand the insight paradox among adolescents. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Utilizing wide area maritime domain awareness (MDA) data to cue a remote surveillance system

NASA Astrophysics Data System (ADS)

Isenor, Anthony W.; Cross, Richard; Webb, Sean; Lapinski, Anna-Liesa S.

2013-10-01

Defence Research and Development Canada - Atlantic (DRDC Atlantic) is currently involved in research on the topic of northern Maritime Domain Awareness (MDA). One project, entitled Situational Information for Enabling Development of Northern Awareness (SEDNA), includes research on the exploitation of MDA data in northern areas. One aspect of this research is to utilize wide area MDA data to provide awareness to an unattended, land-based system. Wide area MDA is attained through the use of space-based AIS (SAIS) data, a data feed used by the Canadian Department of National Defence and supplied by the commercial provider exactEarth Ltd. The land-based surveillance system used is the remote northern system constructed within the DRDC Northern Watch Technology Demonstration Project. Northern Watch is a multi-year project intended to show state-of-the-art, unattended, surveillance capabilities in the Canadian north. The link between the SAIS and Northern Watch is provided by a research infrastructure that consists of an assembly of data sources, users, applications, and product management techniques that collectively support research in areas such as information management and MDA data exploitation. High-level descriptions of the systems are provided along with elaboration on the alerting algorithm, the notifications that would be sent to the Northern Watch southern command site, and the resulting actions that could be taken by the Northern Watch surveillance system.

Importance of Ionospheric Gradients for error Correction

NASA Astrophysics Data System (ADS)

Ravula, Ramprasad

Importance of Ionospheric Gradients for error Correction R. Ram Prasad1, P.Nagasekhar2 1Sai Spurthi Institute of Technology-JNTU Hyderabad,2Sai Spurthi Institute of Technology-JNTU Hyderabad Email ID:rams.ravula@gmail.com In India, Indian Space Research Organization (ISRO) has established with an objective to develop space technology and its application to various national tasks. To cater to the needs of civil aviation applications, GPS Aided Geo Augmented Navigation (GAGAN) system is being jointly implemented along with Airports Authority of India (AAI) over the Indian region. The most predominant parameter affecting the navigation accuracy of GAGAN is ionospheric delay which is a function of total number of electrons present in one square meter cylindrical cross sectional area in the line of site direction between the satellite and the user on the earth i.e. Total Electron Content (TEC).The irregular distribution of electron densities i.e. rate of TEC variation, causes Ionospheric gradients such as spatial gradients (Expressed in TECu/km) and temporal gradients (Expressed in TECu /minute). Among the satellite signals arriving to the earth in multiple directions, the signals which suffer from severe ionospheric gradients can be estimated i.e. Rate of TEC Index (ROTI) and Rate of TEC (ROT). These aspects which contribute to errors can be treated for improving GAGAN positional accuracy.

Modified Activated Carbon Perchlorate Sorbents

DTIC Science & Technology

2007-01-25

Yield 4.64 g. Methyl Chloride Alkylated Activated Carbon Methyl chloride (MeCl) treatment was carried out in a tube furnace generally in...with alkylation agents lowers the solution pH as the basic sites are alkylated . In the case of Me2SO4 treatment , the low slurry pH is believed to be...by Cannon and coworkers, the alkylated carbons are not significantly better. In the case of the SAI carbons, ammonia treatment does not result in a

Proceedings SPIE: Conference Digest, International Conference on Infrared and Millimeter Waves (18th) Held in Colchester, United Kingdom on 6-10 September 1993. Volume 2104

DTIC Science & Technology

1993-09-10

effective dielectric constant appears to decrease upon the substitution of PbO, 1. INRODUCTION In V2 05 - TeO2 glasses several studies on equilibrium... glass increases as TeOg is partially replaced by PbO. Previous studies on V20 5 - TeO2 system 4.5 have reported three Infrared absorption bands at 1010...Laboratory, Dr, K,S. Krishnan Road, New Delhi 110012, India. Th4., REFLECTANCE STUDY OF TM,O. GLASSES - AMemon, M,N.Khan, SAI-Dallal, Department of

Joint Services Electronics Program.

DTIC Science & Technology

1986-09-30

IEEE Computer Society Conference on Trends and Aplications , Gaithersburg, MD, 57-62, May 1983. R.W. Miksad, D.W. Choi and E.J. Powers, "Application of...Estimators for Weakl Nonlinear Esti’mation Problems, M.S. Thesis , Dept. of Electrica Engineering, University of Texas at Austin, May 1982. 7 %- (Page...Chen, J. Vac. Sci. Technol. 17,911 (1980). 6. N.I. Cho, Masters Thesis , unpublished. 7. EI-Saied M. Aly and J.P. Stark, J. Appl. Phys. 53(4), 3063

Octodrine: New Questions and Challenges in Sport Supplements

PubMed Central

Catalani, Valeria; Marrinan, Shanna; Elgharably, Yasmine; Chilcott, Robert

2018-01-01

Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods: A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine’s synonyms and chemical isomers. Results: Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as “the next big thing” and “the god of stimulants,” with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions: The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored. PMID:29461475

Turbidity mitigates lead toxicity to cladocerans (Cladocera).

PubMed

García-García, Gerardo; Nandini, S; Sarma, S S S

2006-07-01

To test the hypothesis that sediment would have a synergistic effect on the toxicity of lead to cladocerans, we performed life table demography experiments with two pelagic (Diaphanosoma birgei and Moina micrura) and one littoral (Alona rectangula) cladoceran species. Life table demography experiments were conducted at three levels of turbidity (0, 17 and 170 NTU) and six concentrations of lead (as PbCl2) from 0 to 0.71 mg l(-1). Median lethal concentrations (LC50) forA. rectangula, D. birgei and M. micrura were 7.06 +/- 0.39, 3.16 +/- 0.25 and 3.24 +/- 0.69 mg l(-1) of Pb. Life table study showed that in general, the presence of sediments in test jars allowed an overall increase of 20-75% in both survivorship and reproduction of the cladoceran species exposed to different concentrations of Pb. At 0.04 mg l(-1) of Pb, the population growth rates were 0.127 forA. rectangula, 0.037 for D. birgei and 0.471 d(-1) for M. micrura in the absence of sediments but were elevated in their presence (0.309, 0.141 and 0.722 d(-1), respectively). The data have been discussed in relation to their importance in shallow, turbid Mexican waterbodies.

"Word of mouse": indigenous harm reduction and online consumerism of the synthetic compound methoxphenidine.

PubMed

Van Hout, Marie Claire; Hearne, Evelyn

2015-01-01

Methoxphenidine (MXP) was one of several NMDA antagonists marketed in 2013 to replace the recently controlled compound Methoxetamine (MXE). A steep rise in user interest was recorded, despite vendor cautioning of limited user feedback. The study presented a phenomenological analysis of MXP experiences amongst recreational drug users as posted on public Internet fora. Internet searches were carried out using specific key words; "methoxphenidine," "MXP" and in combination with "experience," "report," "forum," and "trip." Seven self-reported experiences and 28 thread discussions relating sole use of MXP were analyzed using the Empirical Phenomenological Psychological method. Five themes and 61 categories emerged. MXP is marketed as a legal replacement for MXE, diphenidine, and ketamine, with a dissociative and stimulant wave outcome often lasting for days. Harm reduction tactics, awareness of prior tolerance to dissociative and optimal settings for use are discussed. Acute side-effects relate to hypertension and seizures. Chronic long-term memory loss and limb numbness is reported. Sense of empowerment occurs in the afterglow experience. Internet drug fora fuel information exchange and informed consumerism of synthetic compounds, and offer viable mechanisms for pre- and post-purchase decision making and indigenous harm reduction. Continued surveillance of synthetic market entries and user trends is warranted.

Octodrine: New Questions and Challenges in Sport Supplements.

PubMed

Catalani, Valeria; Prilutskaya, Mariya; Al-Imam, Ahmed; Marrinan, Shanna; Elgharably, Yasmine; Zloh, Mire; Martinotti, Giovanni; Chilcott, Robert; Corazza, Ornella

2018-02-20

Background : Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950's, it has recently been re-introduced on the market as a pre-workout and 'fat-burner' product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods : A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine's synonyms and chemical isomers. Results : Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as "the next big thing" and "the god of stimulants," with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions : The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored.

Solar-energy an American India (SAI) partnership: The Ramakrishna Mission PV Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ullal, H.S.; Stone, J.L.

1997-12-01

This paper describes a cooperative program which was established in 1993 by the Minister of the Indian Ministry of Non-Conventional Energy Sources (MNES) and the Secretary of the U.S. Department of Energy (USDOE). Eventually it fielded one project, funded 50-50 for a total of 500k dollars. The project selected was a sustainable rural economic development initiative with Ramakrishna Mission in West Bengal, India, as the nongovernment organization (NGO). The objectives of the program were to establish the economic viability of photovoltaic power in the Sundarbans region of West Bengal. To have the project self-sustaining with minimal subsidies to the beneficiaries.more » To establish the infrastructure for financing, training, installation and maintenance with the NGO taking the lead. To work with the NGO to expand utilization of photovoltaics in the region. To perform a before and after social, economic, and environmental impact study with the Tata Energy Research Institute.« less

JPRS Report, Science & Technology, Europe & Latin America, Brazil: Selections from the 1987 Federal S&T Budget.

DTIC Science & Technology

1988-02-24

of Goias 67 . Federal University of the State of Rio de Janeiro 68 . Federal University of Juiz de Fora 68 . Federal University of Minas Gerais...Federal University of Rio Grande do Norte 72 . Federal University of Rio Grande do Sul • 72 . Federal University of Rio de Janeiro 73...University of Rio de Janeiro 75 . School of Agrarian Sciences of Para 76 . School of Medicine of the Minas Triangle 77 . Federal Technological Education

Seeking consensus on universal health coverage indicators in the sustainable development goals.

PubMed

Reddock, Jennifer

2017-01-01

There is optimism that the inclusion of universal health coverage in the Sustainable Development Goals advances its prominence in global and national health policy. However, formulating indicators for Target 3.8 through the Inter-Agency Expert Group on Sustainable Development Indicators has been challenging. Achieving consensus on the conceptual and methodological aspects of universal health coverage is likely to take some time in multi-stakeholder fora compared with national efforts to select indicators.

Info Based Med Emergency Decision Tools, Rural Mobil Comm

DTIC Science & Technology

2006-10-01

through its ability to deliver and manage a wide variety of environmental sensors – in short, a robotic equivalent of hearing, sight, smell, taste, and...spread of infection . Panasonic Rugged Laptop: At the time of the evaluation, the Panasonic Toughbook was regarded as the industry standard for...a patient’s systolic and diastolic blood pressure, pulse rate, temperature, and oxygen saturation ( SpO2 ). The front of the device contains an LCD

Autonomous Mobile Robots.

DTIC Science & Technology

1986-01-30

main food. Elephant brains are three times human size. Elephants form matriarchal tribal societies and exhibit complex behavior. Indian domestic...line triangulation. In XVth Int’l Congress of Photogrammetry and Remote Sensing, Commission III, Part 3a, - ’ * pages 342-362. Int’l Society for...a rigid motion. Psychometrlka 35(2):245-255, June, 1970. [15] C.C. Slama (edltor-in-chlef). I Manual of photo grammfetry. American Society of

The Grand Strategy of Charles de Gaulle

DTIC Science & Technology

1989-09-08

4. TITLE AND SUBTITLE The Grand Startegy of Charles de Gaulle 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...dependent on French influence within NATO and the Common Market . De Gaulle frequently used these fora to veto British and American initiatives. As Cook...the reserve currency. Gold would be the basis of international finance and a French-dominated European Common Market would provide the framework

The Debate over Japan’s International Role: Contending Views of Opinion Leaders during the Persian Gulf Crisis.

DTIC Science & Technology

1991-07-17

prominent and prestigious fora. Perhaps Japan’s leading exponent of the realist school is Seizaburo Sato , professor at Tokyo University, research director...involves Sato’s frank recognition of "how important military strength is to protect peace at this starting point of the post-cold war period.൩ Sato ...in an increasingly interdependent world.34 To Sato , noncoercive forms of power supplement traditional military might but they emphatically do not

Merging Hyperspectural Imagery and Multi Scale Modeling for Laser Lethality

DTIC Science & Technology

2016-02-24

standing aluminum films, (2) the effect of the external gas pressure on the flow structures and the mechanisms of the alumina and oxygen transport to...expansion from Al target irradiated by a continuous wave laser into a supersonic external air flow is investigated in kinetic simulations performed for...a broad range of pressure in the external flow. The results of the simulations reveal a significant effect of the external gas pressure on the flow

Gas Flows in Rocket Motors. Volume 3. Appendix D. Computer Code Listings

DTIC Science & Technology

1989-08-01

Information Service, where it will be available to the general public, including foreign nationals. Prepared for the Astronautics Laboratory (AFSC) Air Force...SYMIMETRIC TRANSONIC NOZZLE FLOW~ IN CENEPAL COORDINATE SYSTEM C+ USING TIME ITERATIVE CD/’CD SCHEME * c VIITH THIN-LAYER APPROXIMATED NAVIER-STOIKE’S...Q( 1,1, 2) ,RHOU( 1, 1)), DIMENSION ADD(4) DIMENSION PRE(4,4), PADD (4) C SAI-DIRECTION ENTRY ADDX COF:F=O.125D0*OMEGAX DO 70 J=I,,JL DO 70 I=1,IL IF

Nano-Electro-Mechanical (NEM) Relay Devices and Technology for Ultra-Low Energy Digital Integrated Circuits

DTIC Science & Technology

2013-05-01

number. 1. REPORT DATE 01 MAY 2013 2. REPORT TYPE 3. DATES COVERED 00-00- 2013 to 00-00- 2013 4. TITLE AND SUBTITLE Nano-Electro-Mechanical (NEM...18 Copyright © 2013 , by the author( s ). All rights reserved. Permission to make digital or hard copies of all or part of this work for personal or...E. Ismail, S .-H. Lo, G. A. Sai- Halasz, R . G. Viswanathan, H.-J. C. Wann, S . J. Wind, and H.- S . Wong, “CMOS scaling into the nanometer regime

Effects of Laser Etching on the Corrosion Susceptibility of SAVY 4000 and Hagan Containers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hyer, Holden Christopher; Duque, Juan; Smith, Paul Herrick

Since the late 1990’s, the Hagan container was used as the primary container for packaging of plutonium-bearing materials. The Hagan design consisted of a threaded closure, a Viton® ORing, a carbon-carbon filter, and a 304L stainless steel (SS) body. Over the years, Hagans have shown vulnerability in their design [1]. In 2008, The Department of Energy (DOE) issued DOE M 441.1-1, Nuclear Material Packaging Manual, which detailed an approach to obtain highconfidence in containers by including specific design requirements, material contents and an approach to determine life span from said contents, and surveillance techniques [2]. In response to both themore » vulnerability issues with the Hagan and DOE M 441.1-1, the SAVY 4000 container with its twist style closure, Viton® O-Ring, Fiberfrax-Gortex filter, and annealed 316L SS body, was designed as the replacement for Hagan containers, but only for a short term lifespan of 5 years [1]. However, both the Hagan and SAVY 4000 are being pushed to maintain a lifespan of 40 years. Therefore, proper confidence must be placed on each component of each container to last a minimum of 40 years. So far, the biggest concern found during surveillance of these containers is corrosion and the potential for failure by corrosion. One concern is that the containers fail due to stress corrosion cracking (SCC), especially around the weld between the collar and the body as welds leave residual stresses. One advantage the SAVY 4000 has is that the body is annealed, but its weld is still susceptible as it was welded after annealing [3, 4]. Moreover, 316L SS is known to have a higher pitting resistance (pits are a precursor to SCC and can also lead to extensive failure of the material), than 304L SS [4]. During recent surveillance activities, two SAVY 4000’s containing Solution Assay Instrument (SAI) solutions were opened. The SAI SAVY 4000’s contained plutonium (Pu) in 3M HCl solution in plastic volumetric flasks placed inside of

Light Fighter Communication - On Today’s Chemical Battlefield

DTIC Science & Technology

1988-06-03

quickly enough, the premature removal of masks, and the handling of contaminated clothing while evacuating patients. 9 Page 23 54 Śr" B. Doctrineo Two...Chemical lI’ Contaminated Areas PAPRICCA) found thai. the current chin strap worn by airborne soldiers is inacequate for.a jump into a 4 contaminated area...place in January 1981 entitled "Mobility Through Contaminated Areas Test (MOCAT)O. This was an eleven day test performed from 17-29 October 1980 at

GuideLine Interchange Format (GLIP): Extensions and Practical Applications

DTIC Science & Technology

2000-09-01

Others have also studied and used GLIF as well6-9 . We chose this formalism because it can be easily (and exactly) represented in a flowchart , a...benefit from guidelines in different formats (algorithms, flowcharts , written text). Guidelines in diagrammatic form such as algorithms are useful for...as long as a task is performed, the GL suggests the next steps. This can be a suitable modality for beginners . On the contrary, it can be "silent

Brief notes on the history of Colloquium Spectroscopicum Internationale

NASA Astrophysics Data System (ADS)

D'Ulivo, Alessandro

2017-12-01

Colloquium Spectroscopicum Internationale (CSI) is a series of conferences devoted to fundamentals and applications of Analytical Spectroscopy, providing an international forum for scientists involved in all branches of Spectroscopy to meet and share their experience, discuss results and applications, and present new ideas. The present edition, CSI XL, has been co-organized with the 9th Euro-Mediterranean Symposium on Laser Induced Breakdown Spectroscopy (9th EMSLIBS), which is one of the fora dedicated to this emerging spectroscopic technique.

Maternal anxiety about a child's diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception.

PubMed

Roth, Roswith; Lynch, Kristian; Lernmark, Barbro; Baxter, Judy; Simell, Tuula; Smith, Laura; Swartling, Ulrica; Ziegler, Anette-G; Johnson, Suzanne B

2015-06-01

To understand the association between life stress, postpartum depression (PD), maternal perception of her child's risk for type 1 diabetes (T1D) and a mother's anxiety about her child's T1D risk in mothers of genetically at risk children in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A short form of the state component (SAI) of the State-Trait Anxiety Inventory, negative life events (LE), the Edinburgh Postnatal Depression Scale (EPDS), and one question about the child's risk of developing T1D risk perceptions (RP) were given to mothers at the 6-month TEDDY clinic visit. The relationship between the four measures was modeled using multiple regressions. Controlling for sociodemographic factors, significant country differences in SAI, LE, EPDS, and RP emerged. LE - particularly interpersonal LE - had a strong association to maternal anxiety about the baby's risk of diabetes. Both evidence of PD and accurate risk perceptions (RPs) about the child's T1D risk were associated with increased maternal anxiety about the child's T1D risk. Heightened maternal anxiety in response to the news that a child is at increased risk for T1D is common. Mothers who have experienced recent negative LE, who experience PD and who accurately understand their child's risk may be particularly vulnerable to high levels of anxiety. The findings reported here need to be confirmed in future prospective studies. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Transcranial magnetic stimulation distinguishes Alzheimer disease from frontotemporal dementia.

PubMed

Benussi, Alberto; Di Lorenzo, Francesco; Dell'Era, Valentina; Cosseddu, Maura; Alberici, Antonella; Caratozzolo, Salvatore; Cotelli, Maria Sofia; Micheli, Anna; Rozzini, Luca; Depari, Alessandro; Flammini, Alessandra; Ponzo, Viviana; Martorana, Alessandro; Caltagirone, Carlo; Padovani, Alessandro; Koch, Giacomo; Borroni, Barbara

2017-08-15

To determine whether a transcranial magnetic stimulation (TMS) multiparadigm approach can be used to distinguish Alzheimer disease (AD) from frontotemporal dementia (FTD). Paired-pulse TMS was used to investigate short-interval intracortical inhibition (SICI) and facilitation (ICF), long-interval intracortical inhibition, and short-latency afferent inhibition (SAI) to measure the activity of different intracortical circuits in patients with AD, patients with FTD, and healthy controls (HC). The primary outcome measures were sensitivity and specificity of TMS measures, derived from receiver operating curve analysis. A total of 175 participants met the inclusion criteria. We diagnosed 79 patients with AD, 64 patients with FTD, and 32 HC. We found that while patients with AD are characterized by a specific impairment of SAI, FTD shows a remarkable dysfunction of SICI-ICF intracortical circuits. With the use of the best indexes, TMS differentiated FTD from AD with a sensitivity of 91.8% and specificity of 88.6%, AD from HC with a sensitivity of 84.8% and specificity of 90.6%, and FTD from HC with a sensitivity of 90.2% and specificity of 78.1%. These results were confirmed in patients with mild disease. TMS is a noninvasive procedure that reliably distinguishes AD from FTD and HC and, if these findings are replicated in larger studies, could represent a useful additional diagnostic tool for clinical practice. This study provides Class III evidence that TMS measures can distinguish patients with AD from those with FTD. © 2017 American Academy of Neurology.

Assessment of the Interconnection between Tampa Bay and the Floridan Aquifer, Florida.

DTIC Science & Technology

1983-06-01

8217 CANAL T. P PESBR SAI 30 MANATEE MEXIC SARSOT COUNTYY MAAE CIT ADECUT 271do Figure .-- ypiANANspEii odcac itiuini ap a (from Got RadGodi, 90)?2 BRADENTO... turbidity of the well water there could change. Typically, the temperature of water in the Floridan aquifer is a constant 230C, and temperature of...water in Hillsborough Bay may range from 14°C to 30°C (Goetz and Goodwin, 1980); while turbidity of water in the Floridan aqui- fer is less than 1 JTU

Publisher Correction: RING tetramerization is required for nuclear body biogenesis and PML sumoylation.

PubMed

Wang, Pengran; Benhenda, Shirine; Wu, Haiyan; Lallemand-Breitenbach, Valérie; Zhen, Tao; Jollivet, Florence; Peres, Laurent; Li, Yuwen; Chen, Sai-Juan; Chen, Zhu; de Thé, Hugues; Meng, Guoyu

2018-05-04

In the originally published version of this Article, the authors Sai-Juan Chen and Zhu Chen were incorrectly listed as being affiliated with 'University Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCC, Hôpital St. Louis 1, Paris 75475, France', and the affiliation 'Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China' was inadvertently omitted. These errors have now been corrected in both the PDF and HTML versions of the Article.

VLSI (Very Large Scale Integrated Circuits) Device Reliability Models.

DTIC Science & Technology

1984-12-01

CIRCUIT COMPLEXITY FAILURE RATES FOR... A- 40 MOS SSI/MSI DEVICES IN FAILURE PER 106 HOURS TABLE 5.1.2.5-19: C1 AND C2 CIRCUIT COMPLEXITY FAILURE RATES FOR...A- 40 MOS SSI/MSI DEVICES IN FAILURE PER 106 HOURS TABLE 5.1.2.5-19: Cl AND C2 CIRCUIT COMPLEXITY FAILURE RATES FOR... A-41 LINEAR DEVICES IN...19 National Semiconductor 20 Nitron 21 Raytheon 22 Sprague 23 Synertek 24 Teledyne Crystalonics 25 TRW Semiconductor 26 Zilog The following companies

The Arab-Israeli Conflict: Effects of Islamization

DTIC Science & Technology

1980-06-06

to the propaed -stare. This ;•: 15 disagreement is still today a prominent feature of thp uolit- ical life of the state of Israel. The principal matter...of a "land offerirg the proper conditions for a people to develop "its o ... and soclaZ life as a naton, actln fora better ’uture. He suggested, for...state was dealinr witb the practical aspeot of the political life , the discord between 18 seculars and religious rose to the level of an actual rift. The

Interprocedural Analysis and the Verification of Concurrent Programs

DTIC Science & Technology

2009-01-01

SSPE ) problem is to compute a regular expression that represents paths(s, v) for all vertices v in the graph. The syntax of regular expressions is as...follows: r ::= ∅ | ε | e | r1 ∪ r2 | r1.r2 | r∗, where e stands for an edge in G. We can use any algorithm for SSPE to compute regular expressions for...a closed representation of loops provides an exponential speedup.2 Tarjan’s path-expression algorithm solves the SSPE problem efficiently. It uses

Effect of Hot Rolling Process on Microstructure and Properties of Low-Carbon Al-Killed Steels Produced Through TSCR Technology

NASA Astrophysics Data System (ADS)

Paul, S. K.; Ahmed, U.; Megahed, G. M.

2011-10-01

Low-carbon Al-killed hot rolled strips for direct forming, cold rolling, and galvanizing applications are produced from the similar chemistry at Ezz Flat Steel (EFS) through thin slab casting and rolling (TSCR) technology. The desired mechanical and microstructural properties in hot bands for different applications are achieved through control of hot rolling parameters, which in turn control the precipitation and growth of AlN. Nitrogen in solid solution strongly influences the yield strength (YS), ductility, strain aging index (SAI), and other formability properties of steel. The equilibrium solubility of AlN in austenite at different temperatures and its isothermal precipitation have been studied. To achieve the formability properties for direct forming, soluble nitrogen is fixed as AlN by coiling the strip at higher temperatures. For stringent cold forming, boron was added below the stoichiometric ratio with nitrogen, which improved the formability properties dramatically. The requirements of hot band for processing into cold rolled and annealed deep drawing sheets are high SAI and fine-grain microstructure. Higher finish rolling and low coiling temperatures are used to achieve these. Fully processed cold rolled sheets from these hot strips at customer's end have shown good formability properties. Coil break marks observed in some coils during uncoiling were found to be associated with yielding phenomenon. The spike height (difference between upper and lower yield stresses) and yield point elongation (YPE) were found to be the key material parameters for the break marks. Factors affecting these parameters have been studied and the coiling temperature optimized to overcome the problem.

Virtual reality intervention for older women with breast cancer.

PubMed

Schneider, Susan M; Ellis, Mathew; Coombs, William T; Shonkwiler, Erin L; Folsom, Linda C

2003-06-01

This study examined the effects of a virtual reality distraction intervention on chemotherapy-related symptom distress levels in 16 women aged 50 and older. A cross-over design was used to answer the following research questions: (1) Is virtual reality an effective distraction intervention for reducing chemotherapy-related symptom distress levels in older women with breast cancer? (2) Does virtual reality have a lasting effect? Chemotherapy treatments are intensive and difficult to endure. One way to cope with chemotherapy-related symptom distress is through the use of distraction. For this study, a head-mounted display (Sony PC Glasstron PLM - S700) was used to display encompassing images and block competing stimuli during chemotherapy infusions. The Symptom Distress Scale (SDS), Revised Piper Fatigue Scale (PFS), and the State Anxiety Inventory (SAI) were used to measure symptom distress. For two matched chemotherapy treatments, one pre-test and two post-test measures were employed. Participants were randomly assigned to receive the VR distraction intervention during one chemotherapy treatment and received no distraction intervention (control condition) during an alternate chemotherapy treatment. Analysis using paired t-tests demonstrated a significant decrease in the SAI (p = 0.10) scores immediately following chemotherapy treatments when participants used VR. No significant changes were found in SDS or PFS values. There was a consistent trend toward improved symptoms on all measures 48 h following completion of chemotherapy. Evaluation of the intervention indicated that women thought the head mounted device was easy to use, they experienced no cybersickness, and 100% would use VR again.

Virtual Reality Intervention for Older Women with Breast Cancer

PubMed Central

SCHNEIDER, SUSAN M.; ELLIS, MATHEW; COOMBS, WILLIAM T.; SHONKWILER, ERIN L.; FOLSOM, LINDA C.

2013-01-01

This study examined the effects of a virtual reality distraction intervention on chemotherapy-related symptom distress levels in 16 women aged 50 and older. A cross-over design was used to answer the following research questions: (1) Is virtual reality an effective distraction intervention for reducing chemotherapy-related symptom distress levels in older women with breast cancer? (2) Does virtual reality have a lasting effect? Chemotherapy treatments are intensive and difficult to endure. One way to cope with chemotherapy-related symptom distress is through the use of distraction. For this study, a head-mounted display (Sony PC Glasstron PLM—S700) was used to display encompassing images and block competing stimuli during chemotherapy infusions. The Symptom Distress Scale (SDS), Revised Piper Fatigue Scale (PFS), and the State Anxiety Inventory (SAI) were used to measure symptom distress. For two matched chemotherapy treatments, one pre-test and two post-test measures were employed. Participants were randomly assigned to receive the VR distraction intervention during one chemotherapy treatment and received no distraction intervention (control condition) during an alternate chemotherapy treatment. Analysis using paired t-tests demonstrated a significant decrease in the SAI (p = 0.10) scores immediately following chemotherapy treatments when participants used VR. No significant changes were found in SDS or PFS values. There was a consistent trend toward improved symptoms on all measures 48 h following completion of chemotherapy. Evaluation of the intervention indicated that women thought the head mounted device was easy to use, they experienced no cybersickness, and 100% would use VR again. PMID:12855087

Assessing the impacts of droughts on net primary productivity in China.

PubMed

Pei, Fengsong; Li, Xia; Liu, Xiaoping; Lao, Chunhua

2013-01-15

Frequency and severity of droughts were projected to increase in many regions. However, their effects of temporal dynamics on the terrestrial carbon cycle remain uncertain, and hence deserve further investigation. In this paper, the droughts that occurred in China during 2001-2010 were identified by using the standardized precipitation index (SPI). Standardized anomaly index (SAI), which has been widely employed in reflecting precipitation, was extended to evaluate the anomalies of net primary productivity (NPP). In addition, influences of the droughts on vegetation were explored by examining the temporal dynamics of SAI-NPP along with area-weighted drought intensity at different time scales (1, 3, 6, 9 and 12 months). Year-to-year variability of NPP with several factors, including droughts, NDVI, radiation and temperature, was analyzed as well. Consequently, the droughts in the years 2001, 2006 and 2009 were well reconstructed. This indicates that SPI could be applied to the monitoring of the droughts in China during the past decade (2001-2010) effectively. Moreover, strongest correlations between droughts and NPP anomalies were found during or after the drought intensities reached their peak values. In addition, some droughts substantially reduced the countrywide NPP, whereas the others did not. These phenomena can be explained by the regional diversities of drought intensity, drought duration, areal extents of the droughts, as well as the cumulative and lag responses of vegetation to the precipitation deficits. Besides the drought conditions, normalized difference vegetation index (NDVI), radiation and temperature also contribute to the interannual variability of NPP. Copyright © 2012 Elsevier Ltd. All rights reserved.

New Variable Stars in the Field of 66 Oph on Digitized Moscow Plates

NASA Astrophysics Data System (ADS)

Samus, N. N.; Antipin, S. V.; Kolesnikova, D. M.; Sat, L. A.; Sokolovsky, K. V.

2010-12-01

Regular photographic observations at the Moscow Observatory began in 1895. The archive of direct and spectroscopic sky photographs kept at the Sternberg Astronomical Institute (SAI) currently contains more than 60000 photographs. The most important part of the Moscow plate stacks are about 22500 direct sky photographs acquired in 1948&-1996 with a 40-cm astrograph, at different sites in Crimea and near Moscow (currently in Nauchny, Crimea). The size of its plates is 30 x 30 cm, corresponding to a 10° x 10° sky field. The limiting magnitude is 17.5m for good-quality plates.

Development and quality assessments of commercial heat production of ATF FeCrAl tubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamamoto, Yukinori

2015-09-01

Development and quality assessment of the 2 nd generation ATF FeCrAl tube production with commercial manufacturers were conducted. The manufacturing partners include Sophisticated Alloys, Inc. (SAI), Butler, PA for FeCrAl alloy casting via vacuum induction melting, Oak Ridge National Laboratory (ORNL) for extrusion process to prepare the master bars/tubes to be tube-drawn, and Rhenium Alloys, Inc. (RAI), North Ridgeville, OH, for tube-drawing process. The masters bars have also been provided to Los Alamos National Laboratory (LANL) who works with Century Tubes, Inc., (CTI), San Diego, CA, as parallel tube production effort under the current program.

An Examination of Cleaning and Gas Freeing Costs of Oil Tankers in Government Service

DTIC Science & Technology

1994-03-01

showing age and wear as exhibited by pervasive rust and peeling of tank coatings. (The author observed at least two different color coatings in...quality and environmental directives. MSC Sealift Class tankers, in particular, are showing their age as evidenced by the declining material condition of...acII5 gs aIIc se e.lleSais4% a a t soo • s a s* f *b Ill lb.a a 4 Ioll IC * I°assl aO~ at 1.1.o Mo eill, a, 44. ft sall ages e gg@i sae $"ef ispe Oe? s

Outer planet probe cost estimates: First impressions

NASA Technical Reports Server (NTRS)

Niehoff, J.

1974-01-01

An examination was made of early estimates of outer planetary atmospheric probe cost by comparing the estimates with past planetary projects. Of particular interest is identification of project elements which are likely cost drivers for future probe missions. Data are divided into two parts: first, the description of a cost model developed by SAI for the Planetary Programs Office of NASA, and second, use of this model and its data base to evaluate estimates of probe costs. Several observations are offered in conclusion regarding the credibility of current estimates and specific areas of the outer planet probe concept most vulnerable to cost escalation.

"Vintage meds": a netnographic study of user decision-making, home preparation, and consumptive patterns of laudanum.

PubMed

Van Hout, Marie Claire; Hearne, Evelyn

2015-04-01

Reviews have commented on rising clandestine manufacture of opiate drug solutions for injecting, and to a lesser extent for oral use. Very little is known about user attempts to culture poppy seeds, widely available on the internet for manufacture of long acting medium-high potency oral solutions, both as poppy seed tea or as opium tincture (laudanum). A netnographic research methodology aimed to provide online consumer insight into user sourcing and decision influences, experiences of home manufacture of laudanum, utilization of opium tincture recipes, and consumptive patterns. A systematic internet search was conducted using the terms: "Laudanum," "Opium tincture," and "Tincture of Opium" in combination with "forum." Following screening of 810 forum threads with exclusion criteria and removal of duplicates, 75 fora threads on 6 online drug fora were analyzed using the empirical phenomenological psychological method. Four themes were generated. Findings illustrated the underpinning of user reminiscing about Victorian use of standardized laudanum, long duration shelf life, and medicinal use for opiate withdrawals with intentions to prepare. Preparation of famous recipes and use of authentic storage bottles boosted nostalgia. Participants appeared well versed in kitchen chemistry processes. Discussions centered on type and amount of alcohol used, use of additives to promote palatability and intoxication effect, homogenization of poppy seeds, and double extraction using opium tincture. Lack of detail available on intoxication experiences, with tentative dosage advised. Development of targeted and credible "counterpublic" harm reduction initiatives situated within online consumerism of communal drug knowledge is warranted.

Drug Vaping: From the Dangers of Misuse to New Therapeutic Devices

PubMed Central

Varlet, V.

2016-01-01

Users of e-cigarettes are unwitting volunteers participating in a worldwide epidemiological study. Because of the obvious benefits of e-cigarettes compared with traditional cigarette smoking, these electronic devices have been introduced all around the world to support tobacco smoking cessation. Same potential harm reduction could be considered by cannabis vaping for marijuana smokers. However, the toxicities of liquids and aerosols remain under investigation because although the use of e-cigarettes is likely to be less harmful than traditional cigarette smoking, trace levels of contaminants have been identified. Simultaneously, other electronic devices, such as e-vaporisers, e-hookahs or e-pipes, have been developed and commercialised. Consequently, misuse of electronic devices has increased, and experimentation has been documented on Internet web fora. Although legal and illegal drugs are currently consumed with these e-devices, no scientific papers are available to support the observations reported by numerous media and web fora. Moreover, building on illegal drug vaping and vaporisation with e-devices (vaping misuse), legal drug vaping (an alternative use of vaping) could present therapeutic benefits, as occurs with medical cannabis vaporisation with table vaporisers. This review seeks to synthesise the problems of e-cigarette and liquid refill toxicity in order to introduce the dangers of illegal and legal drugs consumed using vaping and vaporisation for recreational purposes, and finally, to present the potential therapeutic benefits of vaping as a new administration route for legal drugs. PMID:29051432

Drug Vaping: From the Dangers of Misuse to New Therapeutic Devices.

PubMed

Varlet, V

2016-12-16

Users of e-cigarettes are unwitting volunteers participating in a worldwide epidemiological study. Because of the obvious benefits of e-cigarettes compared with traditional cigarette smoking, these electronic devices have been introduced all around the world to support tobacco smoking cessation. Same potential harm reduction could be considered by cannabis vaping for marijuana smokers. However, the toxicities of liquids and aerosols remain under investigation because although the use of e-cigarettes is likely to be less harmful than traditional cigarette smoking, trace levels of contaminants have been identified. Simultaneously, other electronic devices, such as e-vaporisers, e-hookahs or e-pipes, have been developed and commercialised. Consequently, misuse of electronic devices has increased, and experimentation has been documented on Internet web fora. Although legal and illegal drugs are currently consumed with these e-devices, no scientific papers are available to support the observations reported by numerous media and web fora. Moreover, building on illegal drug vaping and vaporisation with e-devices (vaping misuse), legal drug vaping (an alternative use of vaping) could present therapeutic benefits, as occurs with medical cannabis vaporisation with table vaporisers. This review seeks to synthesise the problems of e-cigarette and liquid refill toxicity in order to introduce the dangers of illegal and legal drugs consumed using vaping and vaporisation for recreational purposes, and finally, to present the potential therapeutic benefits of vaping as a new administration route for legal drugs.

Analysis and Modeling of Multistatic Clutter and Reverberation and Support for the FORA

DTIC Science & Technology

2015-09-30

experiments, the 2014 Nordic Seas experiment. The PI’s technical objectives for the experiment are to characterize and model multistatic bottom clutter... Nordic Seas experiments, as well as other efforts as directed by ONR-OA. APPROACH There is a 6-year ONR OA plan for three large experiments

Maneuvering Aerothermal Technology (MAT) Program. A Method for Coupled Three-Dimensional Inviscid and Integral Boundary Layer Calculations

DTIC Science & Technology

1982-05-01

impervious, flat plate. The friction coefficient and Stanton number for laminar flow are: 0.245 (4.24) 2 e 27. I. V C , tD 0.22 (4.25) and for...A I0 I iISl~i Ai i iI# 2.- cIC ,C ,c c , C ;C - 0Ki of IWc -K.lm0. wowFC 0p-- U. 4~~.0 w mN N a’ IN g e.F .0 f cfýN@-,4 a No pc c % 2 C-, r-’, 4F -6

A Simple Interactive Program to Design Supercavitating Propeller Blades.

DTIC Science & Technology

1982-06-01

Torque coefficient CT - Thrust-load coefficient c - Blade chord length D - Propeller diameter, assumed Dopt - Propeller diameter, optimum F - Blade force...2 ci) (10) where: C = drag to lift ratio A. W ideal advance ratio. At this point, solutions can be made for the radial pitch, ( D x ir XX), and the...t/ D )0 .7 x D ൏ 1C (13) 0.7 C where: C Ia coefficient of lift fora finite foil. Reference 2 states that the optimum value for C . is 0.16 and that

An Evaluation of the Method and a Study of the Factors Involved in Using Fused Caustic Alkali for Preparing Metal Surfaces for Enameling

DTIC Science & Technology

1946-01-01

hyora»-*n rdeaaed by thla »rooeee la i* odtcd on th* wi, Thla nydre» en r«d>JOea the o>.i r .’ Iron lth the raaultamt fora*t]on of forroua...aoltoa aodlua .an altrata and j otamtiuu altrata la nitrate or a el »tare of an Iron UiUf. Tulm p la covered by a «tent UJ aearlnan Steel and...developed ka/ UM . «toelehee Steal Carporatloa, «aa aaeeaaaful for cloonlnf steel »Ire prlcr to electro-, alvnnl el ng. Hila ooaMnwo i recess of

Comparative climate response of using three different aerosol geoengineering techniques to transfer from RCP8.5 to RCP4.5

NASA Astrophysics Data System (ADS)

Muri, Helene; Tjiputra, Jerry; Grini, Alf; Helge Otterå, Odd; Lauvset, Siv K.; Schulz, Michael; Egill Kristjánsson, Jón

2017-04-01

Considering the ambitious climate targets of the Paris Agreement to limit global warming to 2°C, with aspirations of even 1.5°C, questions regarding how to achieve this arise. Geoengineering has been proposed as potential tool in such efforts to minimise global harm from anthropogenic climate change. An Earth system model is here used to evaluate the feasibility of transferring from the high CO2 concentrations scenario RCP8.5 to a middle-of-road scenario, RCP4.5, using geoengineering. Three different atmospheric aerosol - based geoengineering techniques are considered: stratospheric aerosol injections (SAI), marine sky brightening (MSB) and cirrus cloud thinning (CCT). We furthermore assess the climate response to these three methods. The climate of the geoengineered cases are for the most much closer to that of RCP4.5 than RCP8.5 and many anthropogenic global warming symptoms are alleviated. All three techniques result in comparatively the same global temperature evolution. Though there are some notable differences in other climate variables due to the nature of the forcings applied. CCT acts mainly on the longwave part of the radiation budget, as opposed to MSB and SAI acting in the shortwave, yielding a difference in the response, particularly for the hydrological cycle. Finally, the effects of a sudden cessation of large-scale aerosol geoengineering deployment is explored. The climate very rapidly, within few years, reverts back to the path of RCP8.5 post-termination, urging the need for simultaneous mitigation and possibly carbon removal from the atmosphere, even if one would dare to enter into any such form of geoengineering.

Differences between the physiologic and psychologic effects of aromatherapy body treatment.

PubMed

Takeda, Hitomi; Tsujita, Junzo; Kaya, Mitsuharu; Takemura, Masanori; Oku, Yoshitaka

2008-07-01

The wide use of herbal plants and essential oils for the prevention and treatment of diseases dates back to ancient times. However, the scientific basis for the beneficial effects of such plants and oils has not been precisely clarified. The purpose of this study was to evaluate the effects of aromatherapy body treatment on healthy subjects. We compared the physiologic and psychologic effects of aromatherapy body treatment (E), massage treatment with carrier oil alone (C), and rest in healthy adults. Seven (7) female and 6 male volunteers participated as subjects. Each subject underwent 3 trials, in which the Advanced Trail Making Test (ATMT) was given as a stress-inducing task before and after 1 of 3 treatments. The State Anxiety Inventory (SAI), the Visual Analog Scale, and the Face Scale were used to assess anxiety, feelings, and mood, respectively. After the treatments, the SAI score and the feelings of fatigue were decreased, the positive and comfortable feelings were increased, and mood improved significantly in C and E. Furthermore, significant declines in the feelings of mental and total fatigue were maintained even after the second ATMT in E. On the other hand, the cortisol concentration in the saliva did not show significant changes in any of the trials. Secretory immunoglobulin A levels in the saliva increased significantly after all treatments. We conclude that massage treatments, irrespective of the presence of essential oils, are more advantageous than rest in terms of psychologic or subjective evaluations but not in terms of physiologic or objective evaluations. Furthermore, as compared to massage alone, the aromatherapy body treatment provides a stronger and continuous relief from fatigue, especially fatigue of mental origin.

Subacromial impingement syndrome: An electromyographic study of shoulder girdle muscle fatigue.

PubMed

Alizadehkhaiyat, Omid; Roebuck, Margaret M; Makki, Ahmed T; Frostick, Simon P

2018-02-01

Muscle fatigue affecting glenohumeral and/or scapular muscles is suggested as one of the contributing factors to the development of subacromial impingement syndrome (SAIS). Nonetheless, the fatigability of shoulder girdle muscles in association with the pathomechanics of SAIS has not been reported. This study aimed to measure and compare fatigue progression within the shoulder girdle musculature of patients and healthy controls. 75 participants including 39 patients (20 females; 19 males) and 36 healthy controls (15 females; 21 males) participated in the study. Study evaluated the progression of muscle fatigue in 15 shoulder girdle muscles by means of surface and fine-wire EMG during submaximal contraction of four distinct movements (abduction, flexion, internal and external rotation). Shoulder strength, subjective pain experience (McGill Pain Questionnaire), and psychological status (Hospital Anxiety and Depression Scale) were also assessed. The results were compared between patient and control groups according to the gender. Despite marked fatigue observed in the majority of muscles particularly during flexion and abduction at 90°, overall results indicated a lower tendency of fatigue progression in the impingement group across the tests (p < 0.05 - p < 0.001). Shoulder Strength, pain experience, and psychological status were significantly different between the two groups (P < .05). Lower tendency to fatigue progression in the impingement group can be attributed to the presence of fear avoidance and pain-related muscle inhibition, which in turn lead to adaptations in motor programme to reduce muscle recruitment and activation. The significantly higher levels of pain experience and anxiety/depression in the impingement group further support this proposition. Copyright © 2017 Elsevier Ltd. All rights reserved.

Vitamin D deficiency and sun avoidance among university students at Abu Dhabi, United Arab Emirates

PubMed Central

Al Anouti, Fatme; Thomas, Justin; Abdel-Wareth, Laila; Rajah, Jaishen; Grant, William B

2011-01-01

This study offers evidence that vitamin D deficiency could be a major public health burden among young Emirati adults, mostly because of sun deprivation in a sun-blessed country. This study included a random sample of 138 females and 70 males tested for serum 25-hydroxyvitamin D [25(OH)D] status. To further evaluate the predictors of vitamin D status in this population, the study examined diet, obesity and sun exposure. In summer, the mean serum 25(OH)D concentration for females was 20.9 ± 14.9 nmol/L, whereas that for males was 27.3 ± 15.7 nmol/L. Females scored significantly higher than males on the sun avoidance inventory (SAI), indicating that females avoid sun exposure to a greater extent than males, possibly explaining the lower vitamin D status. A significant negative correlation also existed between SAI and vitamin D status (Pearson's r = −0.33; p < 0.01), but no significant association was evident between vitamin D status and body mass index (Pearson's r = 0.03; p = 0.33) or low dietary intake of vitamin D-fortified foods (Pearson's r = 0.08; p = 0.13). The mean serum 25(OH)D concentration for females tested in winter was 31.3 ± 12.3 nmol/L while in the summer, it was 20.9 ± 14.9 nmol/L. This difference was statistically significant, suggesting that seasonal variation plays an important role in vitamin D status in the United Arab Emirates. Fortification of foods and drinks with vitamin D, supplementation and sensible sun exposure are important steps toward minimizing vitamin D deficiency. PMID:22259650

Correlation Between Insight and Capacity to Consent to Research in Subjects With Bipolar Disorder Type I and Schizophrenia.

PubMed

López-Jaramillo, Carlos; Tobler, Chantal Aristizábal; Gómez, Constanza Ovalle; Triana, Jaime Escobar

2016-01-01

Schizophrenia and bipolar disorder type I (BD-I) can affect patient autonomy and capacity to consent to participate in research. Other variables associated with the autonomy of patients must be explored in order to improve the quality of the currently available tools. To evaluate the relationship between insight and the capacity to consent to participate in research in patients with BD-I and schizophrenia. A cross-sectional and longitudinal study was conducted with 120 subjects (40 subjects with schizophrenia, 40 with BD-I, and 40 healthy controls). The tools used were the Scale Assessment Insight-Expanded (SAI-E) and the MacArthur Competence Assessment Tool-Treatment (MacCAT-CR), which was first adapted culturally, and its validity and reliability assessed. The results obtained on each scale were compared and the association between them were evaluated. There is a direct correlation between the capacity to consent to research, measured using the MacCAT-CR tool, and the degree of insight, measured using the SAI-E scale, with an effect size of 1.3 for BD-I and 2.03 for schizophrenia. The results suggest that there is a correlation between the degree of insight and the capacity to consent to research in subjects with schizophrenia and BD-I. Insight should therefore be included as a relevant variable to assess the capacity to consent, and future studies should include it when researching on or designing new tools which aim at a greater respect of patient autonomy. Copyright © 2016 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

The topogenic function of S4 promotes membrane insertion of the voltage-sensor domain in the KvAP channel.

PubMed

Mishima, Eriko; Sato, Yoko; Nanatani, Kei; Hoshi, Naomi; Lee, Jong-Kook; Schiller, Nina; von Heijne, Gunnar; Sakaguchi, Masao; Uozumi, Nobuyuki

2016-12-01

Voltage-dependent K + (K V ) channels control K + permeability in response to shifts in the membrane potential. Voltage sensing in K V channels is mediated by the positively charged transmembrane domain S4. The best-characterized K V channel, KvAP, lacks the distinct hydrophilic region corresponding to the S3-S4 extracellular loop that is found in other K + channels. In the present study, we evaluated the topogenic properties of the transmembrane regions within the voltage-sensing domain in KvAP. S3 had low membrane insertion activity, whereas S4 possessed a unique type-I signal anchor (SA-I) function, which enabled it to insert into the membrane by itself. S4 was also found to function as a stop-transfer signal for retention in the membrane. The length and structural nature of the extracellular S3-S4 loop affected the membrane insertion of S3 and S4, suggesting that S3 membrane insertion was dependent on S4. Replacement of charged residues within the transmembrane regions with residues of opposite charge revealed that Asp 72 in S2 and Glu 93 in S3 contributed to membrane insertion of S3 and S4, and increased the stability of S4 in the membrane. These results indicate that the SA-I function of S4, unique among K + channels studied to date, promotes the insertion of S3 into the membrane, and that the charged residues essential for voltage sensing contribute to the membrane-insertion of the voltage sensor domain in KvAP. © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

Fast-adapting mechanoreceptors are important for force control in precision grip but not for sensorimotor memory.

PubMed

Park, Susanna B; Davare, Marco; Falla, Marika; Kennedy, William R; Selim, Mona M; Wendelschafer-Crabb, Gwen; Koltzenburg, Martin

2016-06-01

Sensory feedback from cutaneous mechanoreceptors in the fingertips is important in effective object manipulation, allowing appropriate scaling of grip and load forces during precision grip. However, the role of mechanoreceptor subtypes in these tasks remains incompletely understood. To address this issue, psychophysical tasks that may specifically assess function of type I fast-adapting (FAI) and slowly adapting (SAI) mechanoreceptors were used with object manipulation experiments to examine the regulation of grip force control in an experimental model of graded reduction in tactile sensitivity (healthy volunteers wearing 2 layers of latex gloves). With gloves, tactile sensitivity decreased significantly from 1.9 ± 0.4 to 12.3 ± 2.2 μm in the Bumps task assessing function of FAI afferents but not in a grating orientation task assessing SAI afferents (1.6 ± 0.1 to 1.8 ± 0.2 mm). Six axis force/torque sensors measured peak grip (PGF) and load (PLF) forces generated by the fingertips during a grip-lift task. With gloves there was a significant increase of PGF (14 ± 6%), PLF (17 ± 5%), and grip and load force rates (26 ± 8%, 20 ± 8%). A variable-weight series task was used to examine sensorimotor memory. There was a 20% increase in PGF when the lift of a light object was preceded by a heavy relative to a light object. This relationship was not significantly altered when lifting with gloves, suggesting that the addition of gloves did not change sensorimotor memory effects. We conclude that FAI fibers may be important for the online force scaling but not for the buildup of a sensorimotor memory. Copyright © 2016 the American Physiological Society.

Installation Restoration Program. Preliminary Assessment: 143rd Tactical Airlift Group, Rhode Island Air National Guard, Quonset State Airport, North Kingstown, Rhode Island

DTIC Science & Technology

1990-06-01

portions of the master plan and preliminary engineering for a new international airport for Lisbon, Portugal , estimated to cost $250 million. Self... sinES awtuc, SiC,9 @, Sta. 0.4.. Loc.’ el v t tim w . made weet of 66 water to. dril Sl thr0 g concrete.~ oa~~ 4.80 L0051 1.450, a. Di caes"J @tknwe...8217:par-i SI17. lilt)*~ fir, Sai~d. irav nir 1 ,l 111.-li 1s -w-i-l, a 6-Inch lent, Of coals ,- t. tint SANUI. li1tle Silt l(ll) GFIAPNhf SISCCULI/ O REMAR

Thermally Induced Vibrations of the Hubble Space Telescope's Solar Array 3 in a Test Simulated Space Environment

NASA Technical Reports Server (NTRS)

Early, Derrick A.; Haile, William B.; Turczyn, Mark T.; Griffin, Thomas J. (Technical Monitor)

2001-01-01

NASA Goddard Space Flight Center and the European Space Agency (ESA) conducted a disturbance verification test on a flight Solar Array 3 (SA3) for the Hubble Space Telescope using the ESA Large Space Simulator (LSS) in Noordwijk, the Netherlands. The LSS cyclically illuminated the SA3 to simulate orbital temperature changes in a vacuum environment. Data acquisition systems measured signals from force transducers and accelerometers resulting from thermally induced vibrations of the SAI The LSS with its seismic mass boundary provided an excellent background environment for this test. This paper discusses the analysis performed on the measured transient SA3 responses and provides a summary of the results.

The Wilhelm Wundt Center and the first graduate program for the history and philosophy of psychology in Brazil: A brief report.

PubMed

Araujo, Saulo de Freitas; Caropreso, Fátima Siqueira; Simanke, Richard Theisen; Castañon, Gustavo Arja

2013-08-01

The expansion of Brazilian universities since 2009 has promoted a general growth and incentive of scientific activities throughout the country, not only in the so-called hard sciences, but also in the human sciences. In this brief report, we announce the creation of two new institutional spaces dedicated to the history and philosophy of psychology at the Federal University of Juiz de Fora (UFJF) in Brazil: the Wilhelm Wundt Center for the History and Philosophy of Psychology (NUHFIP) and the Graduate Program in History and Philosophy of Psychology. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Integrating Research on Global Climate Change and Human Use of the Oceans: a Geospatial Method for Daily Monitoring of Sea Ice and Ship Traffic in the Arctic

NASA Astrophysics Data System (ADS)

Eucker, W.; McGillivary, P. A.

2012-12-01

One apparent consequence of global climate change has been a decrease in the extent and thickness of Arctic sea ice more rapidly than models have predicted, while Arctic ship traffic has likewise increased beyond economic predictions. To ensure representative observations of changing climate conditions and human use of the Arctic Ocean, we concluded a method of tracking daily changes in both sea ice and shipping in the Arctic Ocean was needed. Such a process improves the availability of sea ice data for navigational safety and allows future developments to be monitored for understanding of ice and shipping in relation to policy decisions appropriate to optimize sustainable use of a changing Arctic Ocean. The impetus for this work was the 2009 Arctic Marine Shipping Assessment (AMSA) which provided baseline data on Arctic ship traffic. AMSA was based on responses from circumpolar countries, was manpower intensive, and took years to compile. A more timely method of monitoring human use of the Arctic Ocean was needed. To address this, a method of monitoring sea ice on a scale relevant to ship-navigation (<10km) was developed and implemented in conjunction with arctic ship tracking using S-AIS (Satellite Automatic Identification Systems). S-AIS is internationally required on ships over a certain size, which includes most commercial vessels in the Arctic Ocean. Daily AIS and sea ice observations were chosen for this study. Results of this method of geospatial analysis of the entire arctic are presented for a year long period from April 1, 2010 to March 31, 2011. This confirmed the dominance of European Arctic ship traffic. Arctic shipping is maximal during August and diminishes in September with a minimum in winter, although some shipping continues year-round in perennially ice-free areas. Data are analyzed for the four principal arctic quadrants around the North Pole by season for number and nationality of vessels. The goal of this study was not merely to monitor ship

Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial.

PubMed

Werumeus Buning, Jorien; Touw, Daan J; Brummelman, Pauline; Dullaart, Robin P F; van den Berg, Gerrit; van der Klauw, Melanie M; Kamp, Jasper; Wolffenbuttel, Bruce H R; van Beek, André P

2017-06-01

This study aimed at comparing pharmacokinetics of two different doses of hydrocortisone (HC) in patients with secondary adrenal insufficiency (SAI). Forty-six patients with SAI participated in this randomized double-blind crossover study. Patients received two different doses of HC (0.2-0.3mg HC/kg body weight/day and 0.4-0.6mg HC/kg body weight/day). One- and two-compartment population models for plasma free cortisol, plasma total cortisol and salivary cortisol were parameterized. The individual pharmacokinetic parameters clearance (CL), volume of distribution (V d ), elimination half-life (t 1/2 ), maximum concentration (C max ), and area under the curve (AUC) were calculated. The one-compartment models gave a better description of the data compared to the two-compartment models. Weight-adjusted dosing reduced variability in cortisol exposure with comparable AUCs between weight groups. However, there was large inter-individual variation in CL and V d of plasma free cortisol, plasma total cortisol and salivary cortisol. As a consequence, AUC 24h varied more than 10 fold. Cortisol exposure was increased with the higher dose, but this was dose proportional only for free cortisol concentrations and not for total cortisol. Cortisol concentrations after a doubling of the dose were only dose proportional for free cortisol. HC pharmacokinetics can differ up to 10-fold inter-individually and individual adjustment of treatment doses may be necessary. Doubling of the HC dose in fast metabolizers (patients that showed relative low AUC and thus high clearance compared to other patients), does not result in significantly enhanced exposure during large parts of the day and these patients may need other management strategies. Copyright © 2017 Elsevier Inc. All rights reserved.

Immediate versus modified release hydrocortisone in mitotane-treated patients with adrenocortical cancer.

PubMed

Weigel, Marianne; Hahner, Stefanie; Sherlock, Mark; Agha, Amar; Behan, Lucy Ann; Stewart, Paul M; Arlt, Wiebke; Beier, Daniela; Frey, Kathrin; Zopf, Kathrin; Quinkler, Marcus

2017-04-01

Mitotane induces hepatic CYP3A4 activity, resulting in accelerated cortisol inactivation, and also increases cortisol binding globulin (CBG). Therefore, higher hydrocortisone doses are required in patients with adrenocortical cancer (ACC) on mitotane treatment. Modified release hydrocortisone has not been used in mitotane-treated ACC patients yet. Case series to compare serum cortisol, calculated free serum cortisol and ACTH levels in ACC patients on mitotane treatment with immediate and modified release hydrocortisone. Pharmacokinetics of immediate and modified release hydrocortisone, each administered at a dose of 40-20-0 mg, in nine patients with ACC and adjuvant mitotane treatment. For comparison, ten patients with secondary adrenal insufficiency (SAI) on three different hydrocortisone regimens and ten healthy males were included. Serum cortisol and plasma ACTH were measured by chemiluminescent enzyme immunoassay, and CBG by RIA, followed by calculation of free cortisol. Calculated free serum cortisol levels after 40 mg immediate release hydrocortisone in ACC patients (46 ± 14 nmol/l) were similar to those after 10 mg immediate release hydrocortisone intake in men with SAI (64 ± 16 nmol/l) or to the physiological morning free cortisol levels in healthy subjects (31 ± 5 nmol/l). Compared to immediate release hydrocortisone, free cortisol levels after 40 mg modified release hydrocortisone in ACC patients were significantly lower (12 ± 3 nmol/l; P = 0·03) resulting in a generally lower AUC (98 ± 21 vs 149 ± 37 nmol h/l; P = 0·02). 40-20-0 mg immediate release, but not modified release hydrocortisone, resulted in sufficient glucocorticoid coverage in patients with ACC receiving mitotane treatment. The use of equivalent doses of modified release hydrocortisone preparation should be avoided in patients on mitotane treatment. © 2017 John Wiley & Sons Ltd.

Stem Rust Resistance in a Geographically Diverse Collection of Spring Wheat Lines Collected from Across Africa

PubMed Central

Prins, Renée; Dreisigacker, Susanne; Pretorius, Zakkie; van Schalkwyk, Hester; Wessels, Elsabet; Smit, Corneli; Bender, Cornel; Singh, Davinder; Boyd, Lesley A.

2016-01-01

Following the emergence of the Ug99 lineage of Puccinia graminis f. sp. tritici (Pgt) a collective international effort has been undertaken to identify new sources of wheat stem rust resistance effective against these races. Analyses were undertaken in a collection of wheat genotypes gathered from across Africa to identify stem rust resistance effective against the Pgt races found in Eastern and Southern Africa. The African wheat collection consisted of historic genotypes collected in Kenya, South Africa, Ethiopia, Sudan, Zambia, Morocco, and Tunisia, and current South African breeding lines. Both Bayesian cluster and principal coordinate analyses placed the wheat lines from Sudan in a distinct group, but indicated a degree of genetic relatedness among the other wheat lines despite originating from countries across Africa. Seedling screens with Pgt race PTKST, pedigree information and marker haplotype analysis confirmed the presence of Sr2, Sr36, Sr24, Sr31, and Lr34/Yr18/Sr57 in a number of the lines. A genome-wide association study (GWAS) undertaken with Diversiry Arrays Technology (DArT) and stem rust (Sr) gene associated markers and Stem Area Infected (SAI) and Reaction Type (RT) field phenotypes, collected from trials carried out across two seasons in Kenya in 2009 and in South Africa in 2011, identified 29 marker-trait associations (MTA). Three MTA were in common between SAI and RT, with the biggest effect MTA being found on chromosome 6AS. Two wheat lines, W1406 and W6979 that exhibited high levels of adult plant stem rust resistance were selected to generate bi-parental mapping populations. Only the MTA on chromosomes 6AS and 3BS, and the locus Lr34/Yr18/Sr57 were confirmed following QTL mapping. Additional stem rust resistance QTL, not detected by the GWAS, were found on chromosomes 2BS, 2DL, 3DL, and 4D. PMID:27462322

Improving Fishing Pattern Detection from Satellite AIS Using Data Mining and Machine Learning.

PubMed

de Souza, Erico N; Boerder, Kristina; Matwin, Stan; Worm, Boris

2016-01-01

A key challenge in contemporary ecology and conservation is the accurate tracking of the spatial distribution of various human impacts, such as fishing. While coastal fisheries in national waters are closely monitored in some countries, existing maps of fishing effort elsewhere are fraught with uncertainty, especially in remote areas and the High Seas. Better understanding of the behavior of the global fishing fleets is required in order to prioritize and enforce fisheries management and conservation measures worldwide. Satellite-based Automatic Information Systems (S-AIS) are now commonly installed on most ocean-going vessels and have been proposed as a novel tool to explore the movements of fishing fleets in near real time. Here we present approaches to identify fishing activity from S-AIS data for three dominant fishing gear types: trawl, longline and purse seine. Using a large dataset containing worldwide fishing vessel tracks from 2011-2015, we developed three methods to detect and map fishing activities: for trawlers we produced a Hidden Markov Model (HMM) using vessel speed as observation variable. For longliners we have designed a Data Mining (DM) approach using an algorithm inspired from studies on animal movement. For purse seiners a multi-layered filtering strategy based on vessel speed and operation time was implemented. Validation against expert-labeled datasets showed average detection accuracies of 83% for trawler and longliner, and 97% for purse seiner. Our study represents the first comprehensive approach to detect and identify potential fishing behavior for three major gear types operating on a global scale. We hope that this work will enable new efforts to assess the spatial and temporal distribution of global fishing effort and make global fisheries activities transparent to ocean scientists, managers and the public.

The psychological toll of slum living in Mumbai, India: a mixed methods study

PubMed Central

Subbaraman, Ramnath; Nolan, Laura; Shitole, Tejal; Sawant, Kiran; Shitole, Shrutika; Sood, Kunal; Nanarkar, Mahesh; Ghannam, Jess; Betancourt, Theresa S.; Bloom, David E.; Patil-Deshmukh, Anita

2014-01-01

In India, “non-notified” slums are not officially recognized by city governments; they suffer from insecure tenure and poorer access to basic services than “notified” (government-recognized) slums. We conducted a study in a non-notified slum of about 12,000 people in Mumbai to determine the prevalence of individuals at high risk for having a common mental disorder (i.e., depression and anxiety), to ascertain the impact of mental health on the burden of functional impairment, and to assess the influence of the slum environment on mental health. We gathered qualitative data (six focus group discussions and 40 individual interviews in July-November 2011), with purposively sampled participants, and quantitative data (521 structured surveys in February 2012), with respondents selected using community-level random sampling. For the surveys, we administered the General Health Questionnaire-12 (GHQ) to screen for common mental disorders (CMDs), the WHO Disability Assessment Schedule 2.0 (WHO DAS) to screen for functional impairment, and a slum adversity questionnaire, which we used to create a composite Slum Adversity Index (SAI) score. Twenty-three percent of individuals have a GHQ score ≥5, suggesting they are at high risk for having a CMD. Psychological distress is a major contributor to the slum’s overall burden of functional impairment. In a multivariable logistic regression model, household income, poverty-related factors, and the SAI score all have strong independent associations with CMD risk. The qualitative findings suggest that non-notified status plays a central role in creating psychological distress—by creating and exacerbating deprivations that serve as sources of stress, by placing slum residents in an inherently antagonistic relationship with the government through the criminalization of basic needs, and by shaping a community identity built on a feeling of social exclusion from the rest of the city. PMID:25189736

Assessing anxiety levels and empathic tendency in blood and platelet donors.

PubMed

Kılıç, Suar Çakı; Doğan, Erdoğan; Sevimligül, Gülgün; Yücel, Birsen; Bolat, Fatih; Kavakçı, Onder; Sencan, Mehmet

2013-06-01

In spite of a constantly-increasing requirement for blood transfusion in the world, blood donation does not exhibit an increase at the same rate. In Turkey with a population of 74 million, only 15 per 10,000 people donate blood regularly and rate of voluntary blood donation is very low compared to developed countries. The aim of this study is to determine empathic level of donors and anxiety levels of blood and platelet donors and also to enable comfort and motivation of donors by taking precautions for reducing their anxieties. This prospective and descriptive study was conducted with 100 voluntary donors (50 blood donors, 50 platelet donors) who admitted to Blood Centre of Cumhuriyet University Hospital between 15 March 2012 and 30 April 2012. Average age of these donors was 27 (19-48)years. The mean scores of donors from Empathic Tendency Scale (ETS), State Anxiety Invertory (SAI) and Trait Anxiety Inventory (TAI) were 70 (49-83), 40 (33-45) and 34 (30-44), respectively. ETS score of those donating blood/platelet for the first time was low, >1 is higher in those who donated previously. SAI and TAI scores of blood donors were higher than those of platelet donors (p<0.001) and TAI score was higher in those who donate for the first time (p<0.007) compared to previously donated precipitants. In conclusion, this study underscores that the request of the donor to help others is the most important factor for donation. People frequently donate blood to unfamiliar people and recurring blood donations increase the level of empathy. Donation made during the continuous disclosure is an important factor for being a donor. Copyright © 2013 Elsevier Ltd. All rights reserved.

The psychological toll of slum living in Mumbai, India: a mixed methods study.

PubMed

Subbaraman, Ramnath; Nolan, Laura; Shitole, Tejal; Sawant, Kiran; Shitole, Shrutika; Sood, Kunal; Nanarkar, Mahesh; Ghannam, Jess; Betancourt, Theresa S; Bloom, David E; Patil-Deshmukh, Anita

2014-10-01

In India, "non-notified" slums are not officially recognized by city governments; they suffer from insecure tenure and poorer access to basic services than "notified" (government-recognized) slums. We conducted a study in a non-notified slum of about 12,000 people in Mumbai to determine the prevalence of individuals at high risk for having a common mental disorder (i.e., depression and anxiety), to ascertain the impact of mental health on the burden of functional impairment, and to assess the influence of the slum environment on mental health. We gathered qualitative data (six focus group discussions and 40 individual interviews in July-November 2011), with purposively sampled participants, and quantitative data (521 structured surveys in February 2012), with respondents selected using community-level random sampling. For the surveys, we administered the General Health Questionnaire-12 (GHQ) to screen for common mental disorders (CMDs), the WHO Disability Assessment Schedule 2.0 (WHO DAS) to screen for functional impairment, and a slum adversity questionnaire, which we used to create a composite Slum Adversity Index (SAI) score. Twenty-three percent of individuals have a GHQ score≥5, suggesting they are at high risk for having a CMD. Psychological distress is a major contributor to the slum's overall burden of functional impairment. In a multivariable logistic regression model, household income, poverty-related factors, and the SAI score all have strong independent associations with CMD risk. The qualitative findings suggest that non-notified status plays a central role in creating psychological distress-by creating and exacerbating deprivations that serve as sources of stress, by placing slum residents in an inherently antagonistic relationship with the government through the criminalization of basic needs, and by shaping a community identity built on a feeling of social exclusion from the rest of the city. Copyright © 2014 The Authors. Published by Elsevier

Improving Fishing Pattern Detection from Satellite AIS Using Data Mining and Machine Learning

PubMed Central

Matwin, Stan; Worm, Boris

2016-01-01

A key challenge in contemporary ecology and conservation is the accurate tracking of the spatial distribution of various human impacts, such as fishing. While coastal fisheries in national waters are closely monitored in some countries, existing maps of fishing effort elsewhere are fraught with uncertainty, especially in remote areas and the High Seas. Better understanding of the behavior of the global fishing fleets is required in order to prioritize and enforce fisheries management and conservation measures worldwide. Satellite-based Automatic Information Systems (S-AIS) are now commonly installed on most ocean-going vessels and have been proposed as a novel tool to explore the movements of fishing fleets in near real time. Here we present approaches to identify fishing activity from S-AIS data for three dominant fishing gear types: trawl, longline and purse seine. Using a large dataset containing worldwide fishing vessel tracks from 2011–2015, we developed three methods to detect and map fishing activities: for trawlers we produced a Hidden Markov Model (HMM) using vessel speed as observation variable. For longliners we have designed a Data Mining (DM) approach using an algorithm inspired from studies on animal movement. For purse seiners a multi-layered filtering strategy based on vessel speed and operation time was implemented. Validation against expert-labeled datasets showed average detection accuracies of 83% for trawler and longliner, and 97% for purse seiner. Our study represents the first comprehensive approach to detect and identify potential fishing behavior for three major gear types operating on a global scale. We hope that this work will enable new efforts to assess the spatial and temporal distribution of global fishing effort and make global fisheries activities transparent to ocean scientists, managers and the public. PMID:27367425

Negative emotions affect postoperative scores for evaluating functional knee recovery and quality of life after total knee replacement.

PubMed

Qi, A; Lin, C; Zhou, A; Du, J; Jia, X; Sun, L; Zhang, G; Zhang, L; Liu, M

2016-01-01

This study aimed to determine whether psychological factors affect health-related quality of life (HRQL) and recovery of knee function in total knee replacement (TKR) patients. A total of 119 TKR patients (male: 38; female: 81) completed the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), State Trait Anxiety Inventory (STAI), Eysenck Personality Questionnaire-revised (EPQR-S), Knee Society Score (KSS), and HRQL (SF-36). At 1 and 6 months after surgery, anxiety, depression, and KSS scores in TKR patients were significantly better compared with those preoperatively (P<0.05). SF-36 scores at the sixth month after surgery were significantly improved compared with preoperative scores (P<0.001). Preoperative Physical Component Summary Scale (PCS) and Mental Component Summary Scale (MCS) scores were negatively associated with extraversion (E score) (B=-0.986 and -0.967, respectively, both P<0.05). Postoperative PCS and State Anxiety Inventory (SAI) scores were negatively associated with neuroticism (N score; B=-0.137 and -0.991, respectively, both P<0.05). Postoperative MCS, SAI, Trait Anxiety Inventory (TAI), and BAI scores were also negatively associated with the N score (B=-0.367, -0.107, -0.281, and -0.851, respectively, all P<0.05). The KSS function score at the sixth month after surgery was negatively associated with TAI and N scores (B=-0.315 and -0.532, respectively, both P<0.05), but positively associated with the E score (B=0.215, P<0.05). The postoperative KSS joint score was positively associated with postoperative PCS (B=0.356, P<0.05). In conclusion, for TKR patients, the scores used for evaluating recovery of knee function and HRQL after 6 months are inversely associated with the presence of negative emotions.

Mirror Symmetric Bimanual Movement Priming Can Increase Corticomotor Excitability and Enhance Motor Learning

PubMed Central

Byblow, Winston D.; Stinear, Cathy M.; Smith, Marie-Claire; Bjerre, Lotte; Flaskager, Brian K.; McCambridge, Alana B.

2012-01-01

Repetitive mirror symmetric bilateral upper limb may be a suitable priming technique for upper limb rehabilitation after stroke. Here we demonstrate neurophysiological and behavioural after-effects in healthy participants after priming with 20 minutes of repetitive active-passive bimanual wrist flexion and extension in a mirror symmetric pattern with respect to the body midline (MIR) compared to an control priming condition with alternating flexion-extension (ALT). Transcranial magnetic stimulation (TMS) indicated that corticomotor excitability (CME) of the passive hemisphere remained elevated compared to baseline for at least 30 minutes after MIR but not ALT, evidenced by an increase in the size of motor evoked potentials in ECR and FCR. Short and long-latency intracortical inhibition (SICI, LICI), short afferent inhibition (SAI) and interhemispheric inhibition (IHI) were also examined using pairs of stimuli. LICI differed between patterns, with less LICI after MIR compared with ALT, and an effect of pattern on IHI, with reduced IHI in passive FCR 15 minutes after MIR compared with ALT and baseline. There was no effect of pattern on SAI or FCR H-reflex. Similarly, SICI remained unchanged after 20 minutes of MIR. We then had participants complete a timed manual dexterity motor learning task with the passive hand during, immediately after, and 24 hours after MIR or control priming. The rate of task completion was faster with MIR priming compared to control conditions. Finally, ECR and FCR MEPs were examined within a pre-movement facilitation paradigm of wrist extension before and after MIR. ECR, but not FCR, MEPs were consistently facilitated before and after MIR, demonstrating no degradation of selective muscle activation. In summary, mirror symmetric active-passive bimanual movement increases CME and can enhance motor learning without degradation of muscle selectivity. These findings rationalise the use of mirror symmetric bimanual movement as a priming modality

Dual Innervation of Neonatal Merkel Cells in Mouse Touch Domes

PubMed Central

Luo, Wenqin

2014-01-01

Merkel cell-neurite complexes are specialized mechanosensory end organs that mediate discriminative touch sensation. It is well established that type I slowly adapting (SAI) mechanoreceptors, which express neural filament heavy chain (NFH), innervate Merkel cells. It was previously shown that neurotrophic factor NT3 and its receptor TrkC play crucial roles in controlling touch dome Merkel cell innervation of NFH+ fibers. In addition, nerve fibers expressing another neurotrophic tyrosine receptor kinase (NTRK), Ret, innervate touch dome Merkel cells as well. However, the relationship between afferents responsive to NT3/TrkC signaling and those expressing Ret is unclear. It is also controversial if these Ret+ fibers belong to the early or late Ret+ DRG neurons, which are defined based on the co-expression and developmental dependence of TrkA. To address these questions, we genetically traced Ret+ and TrkC+ fibers and analyzed their developmental dependence on TrkA. We found that Merkel cells in neonatal mouse touch domes receive innervation of two types of fibers: one group is Ret+, while the other subset expresses TrkC and NFH. In addition, Ret+ fibers depend on TrkA for their survival and normal innervation whereas NFH+ Merkel cell innervating fibers are almost unaltered in TrkA mutant mice, supporting that Ret+ and NFH+/TrkC+ afferents are two distinct groups. Ret signaling, on the other hand, plays a minor role for the innervation of neonatal touch domes. In contrast, Merkel cells in the glabrous skin are mainly contacted by NFH+/TrkC+ afferents. Taken together, our results suggest that neonatal Merkel cells around hair follicles receive dual innervation while Merkel cells in the glabrous skin are mainly innervated by only SAI mechanoreceptors. In addition, our results suggest that neonatal Ret+ Merkel cell innervating fibers most likely belong to the late but not early Ret+ DRG neurons. PMID:24637732

An Assessment of the Hypothetical Impact of Drug Abuse on Combat Capability. Volume I.

DTIC Science & Technology

1979-12-01

25 I .4 Jill 1.6 MICROCOPY RESOLUTION TEST CHART NATIONAt BIURIA OF gMANI£ IWOI) A LEVEL AD SAI-80-113-WA AN ASSESSMENT OF THE HYPOTHETICAL IMPACTo OF...potential loss of unit effectiveness in each of these units. The resulting measure of unit effectiveness provides a powerful analy- tic tool for comparing...C *u LL C^ C at ta 0c *j I La u4U *c 11:1 - LuU~ *2 Cj Cc uj cl0 !2o Liq Q 4’ U w 0D 0C cnV cz Co 4-1 LLU 0U 0 U. 4 Ken Rn U, 0 -I 0u L SSMAIDU IIn

Manpower Requirements Report for Fiscal Year 1976

DTIC Science & Technology

1975-02-01

with land, sea, air, and undersea operations. In addition, the Navy is FY 74 FY 75 FY 76 FY 7T sai Civ m Civ F^^, Civ sr Civ H eadquartert; .. 0.4...eventuaJly r esult i r. a lcwer annual access~or. requirerr.ent . Tte FY 1976 plan pr ojects an av~rage l ength of ::i P.itiel enlis tment o f J . 5 yea r...4.« Pe^*»rch *nd ■PTT Cui :Tv >r.»r»l h^nt’«- F^reei: I.»r.ii F-r-^c ~ tte ». 1^»I Air Fcr?«;f ’.•iv«il fcrces Uct!l!»i Fcrcet Ut.C

Liter Flow and Mix Selection in Semiclosed-Circuit Scuba

DTIC Science & Technology

1970-01-27

iCUII*. TO USE IT& JUST MNSWER 130 PRINT "INC OUSTIfWS AS IIIEY APPEAR*’ 130 PRINT 340 PRIN’ ISO PRINT MAXIMUM @11 USAGSE LW sees IŔ INPUT US 170 PRINT...34MINIMUM 03 UISAM "i NODS ISO INPUT U4 90Itoli U4bs 113 10 It0 too "i ISO35 310 PRINT 310 PRINT "ETRY MI STAKE* TNT AGAIN" too PRINT SAI0 as To ISO ...113049 S600467 30 4.79063 5.14876 7047556 so 6.32109 6.98531 10.506 T0 IeSSISS lst’$$IS5 11352 t00 10.1472 1.657,6-1 14.0871 too 1707995 10. 79P 4

Total cross sections for electron scattering by 1-propanol at impact energies in the range 40-500 eV

NASA Astrophysics Data System (ADS)

da Silva, D. G. M.; Gomes, M.; Ghosh, S.; Silva, I. F. L.; Pires, W. A. D.; Jones, D. B.; Blanco, F.; Garcia, G.; Buckman, S. J.; Brunger, M. J.; Lopes, M. C. A.

2017-11-01

Absolute total cross section (TCS) measurements for electron scattering from 1-propanol molecules are reported for impact energies from 40 to 500 eV. These measurements were obtained using a new apparatus developed at Juiz de Fora Federal University—Brazil, which is based on the measurement of the attenuation of a collimated electron beam through a gas cell containing the molecules to be studied at a given pressure. Besides these experimental measurements, we have also calculated TCS using the Independent-Atom Model with Screening Corrected Additivity Rule and Interference (IAM-SCAR+I) approach with the level of agreement between them being typically found to be very good.

Treatment adherence and insight in schizophrenia.

PubMed

Bitter, István; Fehér, László; Tényi, Tamás; Czobor, Pál

2015-01-01

Lack of adherence to treatment in patients with schizophrenia is a major risk factor for poor outcome, including relapse, rehospitalization, and suicide. Poor insight into illness may be a leading cause for partial- or nonadherence since a high proportion of patients with schizophrenia are partially or completely unaware of their mental disorder. The primary objective was to estimate the impact of lack of insight on adherence to medication based on a population of patients in Hungary who had the diagnosis of schizophrenia. The secondary objective was to investigate the association of the different aspects of insight (awareness of illness, the capacity to relabel psychotic experiences as abnormal, treatment acceptance) with (1) recent adherence behavior; (2) current mental state; (3) remission/non-remission status as measured by remission severity criteria; and (4) demographic and treatment history data. This was cross-sectional, noninterventional study, carried out under daily clinical practice conditions, with no influence exerted upon clinical practice in view of the observational nature of the study. Eligibility criteria included: a) patients' age (>18 years), b) diagnosis of schizophrenia (ICD-10), c) signed informed consent, d) no concomitant participation in another clinical trial. Study sites represented Mental Health Centers and outpatient clinics of hospital psychiatric units. Each investigator was asked to enroll patients consecutively. The final analysis sample comprised 262 patients, distributed across 13 sites. The following data were collected: general sociodemographic and clinical data (age, sex, level of education, socioeconomic situation, family support, psychiatric diagnosis, years of evolution, pharmacological and/or psychosocial treatments at the time of inclusion in the study, previous psychiatric admissions), with assessments of the Schedule of Assessing components of Insight (SAI), Compliance Rating Scale (CRS), Clinical Global Impression

Non-Singular Modeling of Rigid Manipulators.

DTIC Science & Technology

1986-12-01

SOJQCE 09 FONDING NoMBERS PROG-RAM PRO,ECT -ASK v1 W K .. Ni ELEMEFNT NO NO NO I ACCES;C)1 NO N ON:-zlVTLvIP ’"fPFILINC OFPTRCI1) TAIT rT( Q ; E RSO...AUTHORIS r eamrred. khavvq’_ .33 " t0 QFOQ 13t)’ E COIRED TO4 DATE OF REPORT lYcir MonfhP Day) S P.%t~r (,),%T S I ; . - A T 0 N& (C)SAI. CODES I i...tr he po--,nt of singul -ar-ity. One solution is to s:e:-, a --,mmamu: t me at r oosit:ocn or to avoid t>i:c’ . alt :- e ::.: n t-.te r *solution is to

Incomplete Sparse Approximate Inverses for Parallel Preconditioning

DOE PAGES

Anzt, Hartwig; Huckle, Thomas K.; Bräckle, Jürgen; ...

2017-10-28

In this study, we propose a new preconditioning method that can be seen as a generalization of block-Jacobi methods, or as a simplification of the sparse approximate inverse (SAI) preconditioners. The “Incomplete Sparse Approximate Inverses” (ISAI) is in particular efficient in the solution of sparse triangular linear systems of equations. Those arise, for example, in the context of incomplete factorization preconditioning. ISAI preconditioners can be generated via an algorithm providing fine-grained parallelism, which makes them attractive for hardware with a high concurrency level. Finally, in a study covering a large number of matrices, we identify the ISAI preconditioner as anmore » attractive alternative to exact triangular solves in the context of incomplete factorization preconditioning.« less

Implementation of public policy on alcohol and other drugs in Brazilian municipalities: comparative studies.

PubMed

Mota, Daniela Belchior; Ronzani, Telmo Mota

2016-07-01

One of the challenges with respect to public health and the abuse of alcohol and other drugs is to implement policies in support of greater co-ordination among various levels of government. In Brazil, policies are formulated by the Secretaria Nacional de Políticas sobre Drogas (SENAD - State Department for Policies on Drugs) and the Ministério da Saúde (MS - Ministry of Health). This study aims to compare implementation of policies adopted by SENAD and MS at the municipal level. Three municipalities were intentionally selected: Juiz de Fora having a larger network of treatment services for alcohol and drug users; Lima Duarte, a small municipality, which promotes the political participation of local actors (COMAD - Municipal Council on Alcohol and Drugs); and São João Nepomuceno, also a small municipality, chosen because it has neither public services specialised to assist alcohol and other drugs users, nor COMAD. Data collection was conducted through interviews with key informants (n = 19) and a review of key documents concerned with municipal policies. Data analysis was performed using content analysis. In Juiz de Fora, there are obstacles regarding the integration of the service network for alcohol and other drug users and also the articulation of local actors, who are predominant in the mental health sector. In Lima Duarte, while there is a link between local actors through COMAD, their actions within the local service network have not been effective. In São João Nepomuceno, there were no public actions in the area of alcohol and drugs, and consequently insufficient local debate. However, some voluntary, non-governmental work has been undertaken. There were weaknesses in the implementation of national-level policies by SENAD and the MS, due to the limited supply of available treatment, assistance and the lack of integration among local actors. © 2015 John Wiley & Sons Ltd.

Continental-shelf Scale Passive Ocean AcousticWaveguide Remote Sensing of Marine Mammals and other Submerged Objects including Detection, Localization, and Classification

NASA Astrophysics Data System (ADS)

Wang, Delin

In this thesis, we develop the basics of the Passive Ocean Acoustic Waveguide Remote Sensing (POAWRS) technique for the instantaneous continental-shelf scale detection, localization and species classification of marine mammal vocalizations. POAWRS uses a large-aperture, densely sampled coherent hydrophone array system with orders of magnitude higher array gain to enhance signal-to-noise ratios (SNR) by coherent beamforming, enabling detection of underwater acoustic signals either two orders of magnitude more distant in range or lower in SNR than a single hydrophone. The ability to employ coherent spatial processing of signals with the POAWRS technology significantly improves areal coverage, enabling detection of oceanic sound sources over instantaneous wide areas spanning 100 km or more in diameter. The POAWRS approach was applied to analyze marine mammal vocalizations from diverse species received on a 160-element Office Naval Research Five Octave Research Array (ONR-FORA) deployed during their feeding season in Fall 2006 in the Gulf of Maine. The species-dependent temporal-spatial distribution of marine mammal vocalizations and correlation to the prey fish distributions have been determined. Furthermore, the probability of detection regions, source level distributions and pulse compression gains of the vocalization signals from diverse marine mammal species have been estimated. We also develop an approach for enhancing the angular resolution and improving bearing estimates of acoustic signals received on a coherent hydrophone array with multiple-nested uniformly-spaced subapertures, such as the ONR-FORA, by nonuniform array beamforming. Finally we develop a low-cost non-oil-filled towable prototype hydrophone array that consists of eight hydrophone elements with real-time data acquisition and 100 m tow cable. The approach demonstrated here will be applied in the development of a full 160 element POAWRS-type low-cost coherent hydrophone array system in the future.

A comparative sequence analysis reveals a common GBD/FH3-FH1-FH2-DAD architecture in formins from Dictyostelium, fungi and metazoa

PubMed Central

Rivero, Francisco; Muramoto, Tetsuya; Meyer, Ann-Kathrin; Urushihara, Hideko; Uyeda, Taro QP; Kitayama, Chikako

2005-01-01

Background Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. Formins act as profilin-modulated processive actin nucleators conserved throughout a wide range of eukaryotes. Results We present a detailed sequence analysis of the 10 formins (ForA to J) identified in the genome of the social amoeba Dictyostelium discoideum. With the exception of ForI and ForC all other formins conform to the domain structure GBD/FH3-FH1-FH2-DAD, where DAD is the Diaphanous autoinhibition domain and GBD/FH3 is the Rho GTPase-binding domain/formin homology 3 domain that we propose to represent a single domain. ForC lacks a FH1 domain, ForI lacks recognizable GBD/FH3 and DAD domains and ForA, E and J have additional unique domains. To establish the relationship between formins of Dictyostelium and other organisms we constructed a phylogenetic tree based on the alignment of FH2 domains. Real-time PCR was used to study the expression pattern of formin genes. Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations. During sexual development, expression of forH and forI displayed a significant increase in fusion competent cells. Conclusion Our analysis allows some preliminary insight into the functionality of Dictyostelium formins: all isoforms might display actin nucleation activity and, with the exception of ForI, might also be susceptible to autoinhibition and to regulation by Rho GTPases. The architecture GBD/FH3-FH1-FH2-DAD appears common to almost all Dictyostelium, fungal and metazoan formins, for which we propose the denomination of conventional formins, and implies a common regulatory mechanism. PMID:15740615

A comparative sequence analysis reveals a common GBD/FH3-FH1-FH2-DAD architecture in formins from Dictyostelium, fungi and metazoa.

PubMed

Rivero, Francisco; Muramoto, Tetsuya; Meyer, Ann-Kathrin; Urushihara, Hideko; Uyeda, Taro Q P; Kitayama, Chikako

2005-03-01

Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. Formins act as profilin-modulated processive actin nucleators conserved throughout a wide range of eukaryotes. We present a detailed sequence analysis of the 10 formins (ForA to J) identified in the genome of the social amoeba Dictyostelium discoideum. With the exception of ForI and ForC all other formins conform to the domain structure GBD/FH3-FH1-FH2-DAD, where DAD is the Diaphanous autoinhibition domain and GBD/FH3 is the Rho GTPase-binding domain/formin homology 3 domain that we propose to represent a single domain. ForC lacks a FH1 domain, ForI lacks recognizable GBD/FH3 and DAD domains and ForA, E and J have additional unique domains. To establish the relationship between formins of Dictyostelium and other organisms we constructed a phylogenetic tree based on the alignment of FH2 domains. Real-time PCR was used to study the expression pattern of formin genes. Expression of forC, D, I and J increased during transition to multi-cellular stages, while the rest of genes displayed less marked developmental variations. During sexual development, expression of forH and forI displayed a significant increase in fusion competent cells. Our analysis allows some preliminary insight into the functionality of Dictyostelium formins: all isoforms might display actin nucleation activity and, with the exception of ForI, might also be susceptible to autoinhibition and to regulation by Rho GTPases. The architecture GBD/FH3-FH1-FH2-DAD appears common to almost all Dictyostelium, fungal and metazoan formins, for which we propose the denomination of conventional formins, and implies a common regulatory mechanism.

Quotidian of accompanying family members in an environment of care: the emergence of hospital tribes.

PubMed

Passos, Silvia da Silva Santos; Pereira, Álvaro; Nitschke, Rosane Gonçalves

2016-01-01

Compreender o relacionamento no quotidiano dos familiares acompanhantes nos cenários de cuidado que se aproximam da metáfora da tribo no ambiente hospitalar. Estudo qualitativo com dados coletados a partir de entrevistas semiestruturadas e observação com 16 familiares acompanhantes de pessoas hospitalizadas com dependência para o autocuidado. Os dados foram submetidos à análise temática e analisados através da metáfora da tribo proposta pela sociologia compreensiva. Os familiares formam um agrupamento social em torno do cuidado onde encontramos as características das tribos: a ambiência emocional; a solidariedade baseada nos vínculos de simpatia e ajuda mútua; a nebulosa afetual no processo interacional; a lógica da fusão nas relações tácteis e a comunhão/religiosidade no processo de ligação numa identidade coletiva. Os familiares na presença do trágico criam agrupamentos sociais que se assemelham a tribos cujo totem é o cuidado. Understand the quotidian relationships of accompanying family members in an environment of care, which are close to the metaphor of a tribe in hospital environment. METHODQualitative study with data gathered from semi-structured interviews and observations with 16 family members accompanying hospitalized individuals with dependence on self-care. Data were submitted to thematic analysis, and analyzed through the metaphor of "tribe" proposed by comprehensive sociology. Family members build up social clusters around caring, where we find traits typical of tribes: emotional ambience; solidarity based on links of sympathy and mutual assistance; an affectual nebula in the process of interaction; a logic of fusion in tactile relations; and communion/religiosity in the process of connecting in a collective identity. In the presence of tragedy, families build social clusters similar to tribes having care as a totem.

Conservation Research Is Not Happening Where It Is Most Needed.

PubMed

Wilson, Kerrie A; Auerbach, Nancy A; Sam, Katerina; Magini, Ariana G; Moss, Alexander St L; Langhans, Simone D; Budiharta, Sugeng; Terzano, Dilva; Meijaard, Erik

2016-03-01

Target 19, set by the Convention on Biological Diversity, seeks to improve the knowledge, science base, and technologies relating to biodiversity. We will fail to achieve this target unless prolific biases in the field of conservation science are addressed. We reveal that comparatively less research is undertaken in the world's most biodiverse countries, the science conducted in these countries is often not led by researchers based in-country, and these scientists are also underrepresented in important international fora. Mitigating these biases requires wide-ranging solutions: reforming open access publishing policies, enhancing science communication strategies, changing author attribution practices, improving representation in international processes, and strengthening infrastructure and human capacity for research in countries where it is most needed.

Fission-track dating of pumice from the KBS Tuff, East Rudolf, Kenya

USGS Publications Warehouse

Hurford, A.J.; Gleadow, A.J.W.; Naeser, C.W.

1976-01-01

Fission-track dating of zircon separated from two pumice samples from the KBS Tuff in the Koobi Fora Formation, in Area 131, East Rudolf, Kenya, gives an age of 2.44??0.08 Myr for the eruption of the pumice. This result is compatible with the previously published K-Ar and 40Ar/ 39Ar age spectrum estimate of 2.61??0.26 Myr for the KBS Tuff in Area 105, but differs from the more recently published K-Ar date of 1.82??0.04 Myr for the KBS Tuff in Area 131. This study does not support the suggestion that pumice cobbles of different ages occur in the KBS Tuff. ?? 1976 Nature Publishing Group.

BONSAI Garden: Parallel knowledge discovery system for amino acid sequences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shoudai, T.; Miyano, S.; Shinohara, A.

1995-12-31

We have developed a machine discovery system BON-SAI which receives positive and negative examples as inputs and produces as a hypothesis a pair of a decision tree over regular patterns and an alphabet indexing. This system has succeeded in discovering reasonable knowledge on transmembrane domain sequences and signal peptide sequences by computer experiments. However, when several kinds of sequences axe mixed in the data, it does not seem reasonable for a single BONSAI system to find a hypothesis of a reasonably small size with high accuracy. For this purpose, we have designed a system BONSAI Garden, in which several BONSAI`smore » and a program called Gardener run over a network in parallel, to partition the data into some number of classes together with hypotheses explaining these classes accurately.« less

An isotopic study of a fluvial-lacustrine sequence: The Plio-Pleistocene koobi fora sequence, East Africa

USGS Publications Warehouse

Cerling, T.E.; Bowman, J.R.; O'Neil, J.R.

1988-01-01

Stable isotopic analyses of Plio-Pleistocene and modern sediments in the fluvial-lacustrine system occupying the Turkana Basin, East Africa provide constraints on the paleoenvironmental and diagenetic histories of the Pliocene through the Recent sediments in the basin. The ??13C values for carbonates in lacustrine sediments range from -15 to +22??? relative to PDB, depending on the varying proportions of CO2 from the atmospheric reservoir and from various metabolic sources. The ??18O values of carbonates in lacustrine sediments indicate that the isotopic composition of paleolake water varied by over 10??? from the Pliocene to the present. The ??13C values for pedogenic carbonates record paleoccologic variations and suggest that C4 plants did not become well established in the preserved depositional parts of the basin until about 1.8 myr ago. The ??18O values pedogenic carbonates suggest a range of over 10??? for the isotopic composition of soil water during this interval. They also suggest a period of major climatic instability from about 3.4 to 3.1 myr and at about 1.8 myr. Together, the ??13C and ??18O values of pedogenic carbonates indicate that the present conditions are as arid and hot as any that had prevailed during deposition of these Plio-Pleistocene sediments. ?? 1988.

Conservation Research Is Not Happening Where It Is Most Needed

PubMed Central

Wilson, Kerrie A.; Auerbach, Nancy A.; Sam, Katerina; Magini, Ariana G.; Moss, Alexander St. L.; Langhans, Simone D.; Budiharta, Sugeng; Terzano, Dilva; Meijaard, Erik

2016-01-01

Target 19, set by the Convention on Biological Diversity, seeks to improve the knowledge, science base, and technologies relating to biodiversity. We will fail to achieve this target unless prolific biases in the field of conservation science are addressed. We reveal that comparatively less research is undertaken in the world’s most biodiverse countries, the science conducted in these countries is often not led by researchers based in-country, and these scientists are also underrepresented in important international fora. Mitigating these biases requires wide-ranging solutions: reforming open access publishing policies, enhancing science communication strategies, changing author attribution practices, improving representation in international processes, and strengthening infrastructure and human capacity for research in countries where it is most needed. PMID:27023288

Abandonment and accessibility in railway historical buildings: Central do Brasil and Leopoldina Railstation.

PubMed

Brasil, C C G; Costa, A M; Castañon, J A B

2012-01-01

This paper aims to demonstrate the evolution of a study in the city of Juiz de Fora-MG, whose objective is the assessment of areas of train station in relation to the inclusion of people with disabilities and consequently promote the historical and cultural heritage of this city. The railway buildings are important landmarks in the history of the city and its surroundings was formed the first core of urban development. Because this building was of the early nineteenth century, these were not designed to assist people with disabilities, in effect, we observed that the buildings are being underutilized. The difficulty of insertion of incentive policies is therefore not due to the commitment by the majority, making the deployment of new access.

The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-Magenis syndrome region at 17p11.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kimura, Toshiyuki; Arakawa, Yoshiki; Inazawa, Johji

1997-03-31

Smith-Magenis syndrome (SAIS) is caused by a microdeletion of 17p11.2 and comprises developmental and growth delay, facial abnormalities, unusual behavior and sleep problems. This phenotype may be due to haploinsufficiency of several contiguous genes. The human brain finger protein gene (ZNF179), a member of the RING finger protein family, has been isolated and mapped to l7p11.2. FISH analyses of metaphase or interphase chromosomes of 6 patients with SMS show that ZNF179 was deleted in one of the 2 homologs (17p11.2), indicating a possible association of the defect of this gene with the pathogenesis of SMS. Furthermore, using a prophase FISHmore » ordering system, we sublocalized ZNF179 proximally to LLGL which lies on the critical region for SMS. 27 refs., 2 figs.« less

Integral throat entrance development, qualification and production for the Antares 3 nozzle

NASA Technical Reports Server (NTRS)

Clayton, F. I.; Dirling, R. B.; Eitman, D. A.; Loomis, W. C.

1982-01-01

Although design analyses of a G-90 graphite integral throat entrance for the Antares 3 solid rocket motor nozzle indicated acceptable margins of safety, the nozzle throat insert suffered a thermostructural failure during the first development firing. Subsequent re-analysis using properties measured on material from the same billet as the nozzle throat insert showed negative margins. Carbon-carbon was investigated and found to result in large positive margins of safety. The G-90 graphite was replaced by SAI fast processed 4-D material which uses Hercules HM 10000 fiber as the reinforcement. Its construction allows powder filling of the interstices after preform fabrication which accelerates the densification process. Allied 15V coal tar pitch is then used to complete densification. The properties were extensively characterized on this material and six nozzles were subjected to demonstration, development and qualification firings.

High mobility and high concentration Type-III heterojunction FET

NASA Astrophysics Data System (ADS)

Tsu, R.; Fiddy, M. A.; Her, T.

2018-02-01

The PN junction was introduced in transistors by doping, resulting in high losses due to Coulomb scattering from the dopants. The MOSFET introduced carriers in the form of electrons and holes with an applied bias to the oxide barrier, resulting in carrier transfer without doping. This avoids high scattering losses and dominates the IC industries. With heterojunctions having valence-band maxima near and even above the conduction-band minimum in the formation of Type-III superlattices, very useful devices, introduced by Tsu, Sai-Halacz, and Esaki, soon followed. If the layer thicknesses are more than the carrier mean-free-path, incoherent scattering results in the formation of carrier transfer via diffusion instead of opening up new energy gaps. The exploitation of carriers without scattering represents a new and significant opportunity in what we call a Broken Gap Heterojunction FET.

Analysis And Assistant Planning System Ofregional Agricultural Economic Inform

NASA Astrophysics Data System (ADS)

Han, Jie; Zhang, Junfeng

For the common problems existed in regional development and planning, we try to design a decision support system for assisting regional agricultural development and alignment as a decision-making tool for local government and decision maker. The analysis methods of forecast, comparative advantage, liner programming and statistical analysis are adopted. According to comparative advantage theory, the regional advantage can be determined by calculating and comparing yield advantage index (YAI), Scale advantage index (SAI), Complicated advantage index (CAI). Combining with GIS, agricultural data are presented as a form of graph such as area, bar and pie to uncover the principle and trend for decision-making which can't be found in data table. This system provides assistant decisions for agricultural structure adjustment, agro-forestry development and planning, and can be integrated to information technologies such as RS, AI and so on.

Aircraft Noise Definition. Phase II. Analysis of Flyover-Noise Data for the DC-8-61 Aircraft

DTIC Science & Technology

1974-08-01

cocnfidence limfits. 41 TAOLS 4 ALTIYTM TO mu1HCH Wsosoin 1~1n 110A M.IITVIM DATA Sd NOM 1U3. 0O. OF DATA OUAIS 410m m 3 it 0M441405 US 0 .0? 1147.166 IsoS ...100 611 CU)%?I󈧬# )M301110 so IM I’ll 00001 WAO It CALL. C0660 tI LTINIUSTof Pt.L vVPlA.RPIWE’~.tCdt~iVkl )00011iU0 ?OV&Lm IPO. 00001 1410 AP9VCLG ISO ...1 J0001210 $22 CYRUE a £50. 11 tT1NUST-264)0I I.%I3E0.b-*4o0. 144 140.10. - ISO ) lflA22 I~u?*M.1 0001230 sai ~r 504T1 100 3 1240 14 CAL sl’ot

Spatial and temporal variation of body size among early Homo.

PubMed

Will, Manuel; Stock, Jay T

2015-05-01

The estimation of body size among the earliest members of the genus Homo (2.4-1.5Myr [millions of years ago]) is central to interpretations of their biology. It is widely accepted that Homo ergaster possessed increased body size compared with Homo habilis and Homo rudolfensis, and that this may have been a factor involved with the dispersal of Homo out of Africa. The study of taxonomic differences in body size, however, is problematic. Postcranial remains are rarely associated with craniodental fossils, and taxonomic attributions frequently rest upon the size of skeletal elements. Previous body size estimates have been based upon well-preserved specimens with a more reliable species assessment. Since these samples are small (n < 5) and disparate in space and time, little is known about geographical and chronological variation in body size within early Homo. We investigate temporal and spatial variation in body size among fossils of early Homo using a 'taxon-free' approach, considering evidence for size variation from isolated and fragmentary postcranial remains (n = 39). To render the size of disparate fossil elements comparable, we derived new regression equations for common parameters of body size from a globally representative sample of hunter-gatherers and applied them to available postcranial measurements from the fossils. The results demonstrate chronological and spatial variation but no simple temporal or geographical trends for the evolution of body size among early Homo. Pronounced body size increases within Africa take place only after hominin populations were established at Dmanisi, suggesting that migrations into Eurasia were not contingent on larger body sizes. The primary evidence for these marked changes among early Homo is based upon material from Koobi Fora after 1.7Myr, indicating regional size variation. The significant body size differences between specimens from Koobi Fora and Olduvai support the cranial evidence for at least two co

Boreal forest health and global change.

PubMed

Gauthier, S; Bernier, P; Kuuluvainen, T; Shvidenko, A Z; Schepaschenko, D G

2015-08-21

The boreal forest, one of the largest biomes on Earth, provides ecosystem services that benefit society at levels ranging from local to global. Currently, about two-thirds of the area covered by this biome is under some form of management, mostly for wood production. Services such as climate regulation are also provided by both the unmanaged and managed boreal forests. Although most of the boreal forests have retained the resilience to cope with current disturbances, projected environmental changes of unprecedented speed and amplitude pose a substantial threat to their health. Management options to reduce these threats are available and could be implemented, but economic incentives and a greater focus on the boreal biome in international fora are needed to support further adaptation and mitigation actions. Copyright © 2015, American Association for the Advancement of Science.

Additional results on palaeomagnetic stratigraphy of the Koobi Fora Formation, east of Lake Turkana (Lake Rudolf), Kenya

USGS Publications Warehouse

Hillhouse, J.W.; Ndombi, J.W.M.; Cox, A.; Brock, A.

1977-01-01

The magnetostratigraphy of the hominid-bearing sediments exposed east of Lake Turkana has been strengthened by new palaeomagnetic results. Ages obtained from several tuffs by the 40Ar/39Ar method suggest an approxmate match between the observed magnetozones and the geomagnetic polarity time scale; however, the palaeomagnetic results are also compatible with a younger chronology suggested by conventional K-Ar dating of the KBS Tuff. ?? 1977 Nature Publishing Group.

What Are We Aiming For?--A Delphi Study on the Development of Civic Scientific Literacy in Sweden

ERIC Educational Resources Information Center

Chang Rundgren, Shu-Nu; Rundgren, Carl-Johan

2017-01-01

Based on the EU FP 7 project, PROFILES, this article presents our findings from a three-round Delphi study conducted in Sweden that aimed at establishing a consensus on how science education should be developed for citizens to enhance civic scientific literacy. A total of 100 stakeholders (9th graders, school teachers, scientists, and science…

The firing characteristics of foot sole cutaneous mechanoreceptor afferents in response to vibration stimuli.

PubMed

Strzalkowski, Nicholas D J; Ali, R Ayesha; Bent, Leah R

2017-10-01

Single unit microneurography was used to record the firing characteristics of the four classes of foot sole cutaneous afferents [fast and slowly adapting type I and II (FAI, FAII, SAI, and SAII)] in response to sinusoidal vibratory stimuli. Frequency (3-250 Hz) and amplitude (0.001-2 mm) combinations were applied to afferent receptive fields through a 6-mm diameter probe. The impulses per cycle, defined as the number of action potentials evoked per vibration sine wave, were measured over 1 s of vibration at each frequency-amplitude combination tested. Afferent entrainment threshold (lowest amplitude at which an afferent could entrain 1:1 to the vibration frequency) and afferent firing threshold (minimum amplitude for which impulses per cycle was greater than zero) were then obtained for each frequency. Increases in vibration frequency are generally associated with decreases in expected impulses per cycle ( P < 0.001), but each foot sole afferent class appears uniquely tuned to vibration stimuli. FAII afferents tended to have the lowest entrainment and firing thresholds ( P < 0.001 for both); however, these afferents seem to be sensitive across frequency. In contrast to FAII afferents, SAI and SAII afferents tended to demonstrate optimal entrainment to frequencies below 20 Hz and FAI afferents faithfully encoded frequencies between 8 and 60 Hz. Contrary to the selective activation of distinct afferent classes in the hand, application of class-specific frequencies in the foot sole is confounded due to the high sensitivity of FAII afferents. These findings may aid in the development of sensorimotor control models or the design of balance enhancement interventions. NEW & NOTEWORTHY Our work provides a mechanistic look at the capacity of foot sole cutaneous afferents to respond to vibration of varying frequency and amplitude. We found that foot sole afferent classes are uniquely tuned to vibration stimuli; however, unlike in the hand, they cannot be independently

Exploring scientific creativity of eleventh-grade students in Taiwan

NASA Astrophysics Data System (ADS)

Liang, Jia-Chi

2002-04-01

Although most researchers focus on scientists' creativity, students' scientific creativity should be considered, especially for high school and college students. It is generally assumed that most professional creators in science emerge from amateur creators. Therefore, the purpose of this study is to investigate the relationship between students' scientific creativity and selected variables including creativity, problem finding, formulating hypotheses, science achievement, the nature of science, and attitudes toward science for finding significant predictors of eleventh grade students' scientific creativity. A total of 130 male eleventh-grade students in three biology classes participated in this study. The main instruments included the Test of Divergent Thinking (TDT) for creativity measurement, the Creativity Rating Scale (CRS) and the Creative Activities and Accomplishments Check Lists (CAACL ) for measurement of scientific creativity, the Nature of Scientific Knowledge Scale (NSKS) for measurement of the nature of science, and the Science Attitude Inventory II (SAI II) for measurement of attitudes toward science. In addition, two instruments on measuring students' abilities of problem finding and abilities of formulating hypotheses were developed by the researcher in this study. Data analysis involved descriptive statistics, Pearson product-moment correlations, and stepwise multiple regressions. The major findings suggested the following: (1) students' scientific creativity significantly correlated with some of selected variables such as attitudes toward science, problem finding, formulating hypotheses, the nature of science, resistance to closure, originality, and elaboration; (2) four significant predictors including attitudes toward science, problem finding, resistance to closure, and originality accounted for 48% of the variance of students' scientific creativity; (3) there were big differences between students with a higher and a lower degree of scientific

Calcific tendinitis of the rotator cuff: a randomized controlled trial of ultrasound-guided needling and lavage versus subacromial corticosteroids.

PubMed

de Witte, Pieter Bas; Selten, Jasmijn W; Navas, Ana; Nagels, Jochem; Visser, Cornelis P J; Nelissen, Rob G H H; Reijnierse, Monique

2013-07-01

Calcific tendinitis of the rotator cuff (RCCT) is frequently diagnosed in patients with shoulder pain, but there is no consensus on its treatment. To compare 2 regularly applied RCCT treatments: ultrasound (US)-guided needling and lavage (barbotage) combined with a US-guided corticosteroid injection in the subacromial bursa (subacromial bursa injection [SAI]) (group 1) versus an isolated SAI (group 2). Randomized controlled trial; Level of evidence, 1. Patients were randomly assigned to the 2 groups. Shoulder function was assessed before treatment and at regular follow-up intervals (6 weeks and 3, 6, and 12 months) using the Constant shoulder score (CS, primary outcome), the Western Ontario Rotator Cuff Index (WORC), and the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH). Additionally, calcification location, size, and Gärtner classification were assessed on radiographs. Results were analyzed using the t test, linear regression, and a mixed model for repeated measures. This study included 48 patients (25 female, 52.1%; mean age, 52.0 ± 7.3 years; 23 patients in group 1) with a mean baseline CS of 68.7 ± 11.9. No patients were lost to follow-up. Four patients in group 1 and 11 in group 2 (P = .06) had an additional barbotage procedure or surgery during the follow-up period because of persisting symptoms and no resorption. At 1-year follow-up, the mean CS in group 1 was 86.0 (95% CI, 80.3-91.6) versus 73.9 (95% CI, 67.7-80.1) in group 2 (P = .005). The mean calcification size decreased by 11.6 ± 6.4 mm in group 1 and 5.1 ± 5.7 mm in group 2 (P = .001). There was total resorption in 13 patients in group 1 and 6 patients in group 2 (P = .07). With regression analyses, correcting for baseline CS and Gärtner type, the mean treatment effect was 20.5 points (P = .05) in favor of barbotage. Follow-up scores were significantly influenced by baseline scores. Results for the DASH and WORC were similar. On average, there was improvement at 1-year follow

Who shall live when not all can live? Intellectual property in accessing and benefit-sharing influenza viruses through the World Health Organisation.

PubMed

Lawson, Charles

2011-03-01

This article addresses the development of the World Health Organisation's (WHO) arrangements for accessing viruses and the development of vaccines to respond to potential pandemics (and other lesser outbreaks). It examines the ongoing "conflict" between the United Nations' Convention on Biological Diversity (CBD) and the World Trade Organisation's Agreement on Trade Related Aspects of Intellectual Property Rights (TRIPS) in the context of the debates about the paramountcy of intellectual property, and the potential for other (equity and development) imperatives to over-ride respect for intellectual property and TRIPS. The article concludes that the same intellectual property fault lines are evident in the WHO forum as those apparent at the CBD and the WTO fora, and an ongoing failure to properly address questions of equity and development. This poses a challenge for the Australian Government in guaranteeing a satisfactory pandemic influenza preparation and response.

Don't bother to wrap it: online Giftgiver and Bugchaser newsgroups, the social impact of gift exchanges and the 'carnivalesque'.

PubMed

Graydon, Michael

2007-01-01

At online internet newsgroups, members who self-identify as Giftgivers and Bugchasers post messages describing exchanging HIV as a gift, as the Gift. Using the literature on the social function of gift exchanges, this paper considers how Giftgiver and Bugchaser messages mobilize the language of gifts. In doing so, newsgroup members generate an ontological narrative wherein HIV, as the Gift, promotes social bonds, the creation and maintenance of self identity and social roles, and the meeting of particular goals. Thus the Gift appears to fulfill (at least discursively) many of the social functions of gift exchanges as described in the literature. Online newsgroups function as fora for the expression of a contrarian, transgressive HIV/AIDS narrative and act as 'carnivalesque' spaces in which normative social roles and meaning are inverted in the establishment of a realm whereby HIV becomes a gift.

Does self-esteem affect body dissatisfaction levels in female adolescents?☆

PubMed Central

Fortes, Leonardo de Sousa; Cipriani, Flávia Marcele; Coelho, Fernanda Dias; Paes, Santiago Tavares; Ferreira, Maria Elisa Caputo

2014-01-01

Objective: To evaluate the influence of self-esteem on levels of body dissatisfaction among adolescent females. Methods: A group of 397 adolescents aged 12 to 17 years were enrolled in the study. The Body Shape Questionnaire (BSQ) was applied to assess body dissatisfaction. The Rosenberg Self-Esteem Scale was used to assess self-esteem. Weight, height, and skinfold thickness were also measured. These anthropometric data were controlled in the statistical analyses. Results: The multiple regression model indicated influence of "positive self-esteem" (R2=0.16; p=0.001) and "negative self-esteem" (R2=0.23; p=0.001) subscales on the BSQ scores. Univariate analysis of covariance demonstrated differences in BSQ scores (p=0.001) according to groups of self-esteem. Conclusion: It was concluded that self-esteem influenced body dissatisfaction in adolescent girls from Juiz de Fora, MG. PMID:25479855

The social nature of chronic noncommunicable diseases and how to tackle them through communication technology, training, and outreach.

PubMed

Martin-Moreno, Jose M; Apfel, Franklin; Sanchez, Jose Luis Alfonso; Galea, Gauden; Jakab, Zsuzsanna

2011-08-01

As world leaders prepare for the United Nations High Level Meeting on Noncommunicable Diseases, to take place in September 2011, international organizations, nongovernmental organizations, and economic and business fora have created new alliances and initiatives to accelerate research, advocacy, and political commitment. This article argues that the time is propitious to reflect on the social nature of the most common behavioral noncommunicable disease determinants, including tobacco and alcohol use, physical inactivity, and unhealthy diet. Evidence is presented related to the fact that these diseases are profoundly rooted in social and community ties and points to the need for a modern communication strategy to serve as a linchpin of any successful action to address these public health threats. Several proposals, aimed at promoting health literacy, strengthening health workforce skills, capturing the power of new media and technologies, and targeting vulnerable groups, are discussed.

Comfort and anxiety levels of women with early stage breast cancer who receive radiotherapy.

PubMed

Tuncer, Gamze; Yucel, Sebnem Cinar

2014-01-01

The aim of this planned research was to determine the comfort and anxiety levels of women with breast cancer receiving radiotherapy. This descriptive type study covered patients that applied to the radiation oncology breast polyclinic of our university hospital between January and May 2011. Patient Identification Form, Radiation Therapy Comfort Questionnaire (RTCQ), Spielberger State Trait Anxiety Inventory (STAI) were completed and analysed. The mean age of the women who participated in the study was 51.6 ± 10.4 years. Mean scores of women were 3.73 ± 0.31 for RTCQ, 29.1 ± 5.88 for SAI and 37.8±6.91 for TAI. While the comfort levels of the women with breast cancer receiving radiotherapy were moderate, they experienced only low levels of anxiety. By determining the comfort level of the patient before radiotherapy, besides providing comfort in this direction, eliminating/minimizing anxiety and stress will positively affect radiotherapy application. More attention of nurses to this issue is to be recommended.

Constraints on the formation of layered tektites from the excavation and analysis of layered tektites from northeast Thailand

NASA Astrophysics Data System (ADS)

Fiske, Peter S.

1996-01-01

The size, shape, composition, and vesicle content of 6 kg of layered tektite fragments, excavated near the town of Huai Sai, Thailand, place some constraints on the formation of layered tektites. The mass, shape, and distribution of the fragments are not consistent with an origin as a "puddle" of impact melt but suggest that they were derived from a single equant block. The presence of vesicles up to 7 mm in mean diameter within the tektite fragments suggests that the material was too viscous to allow for significant gravity-driven flow. These results suggest that layered tektites may be analogous to lava bombs, which may have been stretched and deformed in flight but underwent little flow after landing. Rather than being a product of "unusual circumstances," such as multiple impacts, layered tektites may differ from splash-form tektites only in initial temperature of formation, speed of ejection, and small differences in initial composition.

Carbothermic reduction of uranium oxides into solvent metallic baths

NASA Astrophysics Data System (ADS)

Guisard Restivo, Thomaz A.; Capocchi, José D. T.

2004-09-01

The carbothermic reduction of UO 2 and U 3O 8 is studied employing tin and silicon solvent metallic baths in thermal analysis equipment, under Ar inert and N 2 reactive atmospheres. The metallic solvents are expected to lower the U activity by several orders of magnitude owing to strong interactions among the metals. The reduction products are composed of the solvent metal matrix and intermetallic U compounds. Silicon is more effective in driving the reduction since there is no residual UO 2 after the reaction. The gaseous product detected by mass spectrometer (MS) during the reduction is CO. A kinetic study for the Si case was accomplished by the stepwise isothermal analysis (SAI) method, leading to the identification of the controlling mechanisms as chemical reaction at the surface and nucleation, for UO 2 and U 3O 8 charges, respectively. One example for another system containing Al 2O 3 is also shown.

The Brazilian Audit Tribunal's role in improving the federal environmental licensing process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lima, Luiz Henrique, E-mail: luizhlima@terra.com.b; Magrini, Alessandra, E-mail: ale@ppe.ufrj.b; Centro de Tecnologia - Bloco C Sala 211, Ilha do Fundao, 21949-900 - Rio de Janeiro, Caixa-Postal: 68565, RJ

This article describes the role played by the Brazilian Audit Tribunal (Tribunal de Contas da Uniao - TCU) in the external auditing of environmental management in Brazil, highlighting the findings of an operational audit conducted in 2007 of the federal environmental licensing process. Initially, it records the constitutional and legal framework of Brazilian environmental licensing, describing the powers and duties granted to federal, state and municipal institutions. In addition, it presents the responsibilities of the TCU in the environmental area, comparing these with those of other Supreme Audit Institutions (SAI) that are members of the International Organization of Supreme Auditmore » Institutions (INTOSAI). It also describes the work carried out in the operational audit of the Brazilian environmental licensing process and its main conclusions and recommendations. Finally, it draws a parallel between the findings and recommendations made in Brazil with those of academic studies and audits conducted in other countries.« less

Soil-Gas Radon Anomaly Map of an Unknown Fault Zone Area, Chiang Mai, Northern Thailand

NASA Astrophysics Data System (ADS)

Udphuay, S.; Kaweewong, C.; Imurai, W.; Pondthai, P.

2015-12-01

Soil-gas radon concentration anomaly map was constructed to help detect an unknown subsurface fault location in San Sai District, Chiang Mai Province, Northern Thailand where a 5.1-magnitude earthquake took place in December 2006. It was suspected that this earthquake may have been associated with an unrecognized active fault in the area. In this study, soil-gas samples were collected from eighty-four measuring stations covering an area of approximately 50 km2. Radon in soil-gas samples was quantified using Scintrex Radon Detector, RDA-200. The samplings were conducted twice: during December 2014-January 2015 and March 2015-April 2015. The soil-gas radon map obtained from this study reveals linear NNW-SSE trend of high concentration. This anomaly corresponds to the direction of the prospective fault system interpreted from satellite images. The findings from this study support the existence of this unknown fault system. However a more detailed investigation should be conducted in order to confirm its geometry, orientation and lateral extent.

Spiritual Development and Death Attitude in Female Patients With Type II Diabetes

PubMed Central

Nozari, Masoumeh; Khalilian, Alireza; Dousti, Yarali

2014-01-01

Objective: The present study aimed to investigate the differences regarding spiritual development dimensions and death attitude profiles, and also to determinate association between them, in patients suffering from type II diabetes. Methods: In a cross-sectional design study, 100 female outpatients who were suffering from type II diabetes were recruited in Imam Khomeini Hospital, Sari, Iran. Data were collected through two questionnaires including the Spiritual Assessment Inventory (SAI) and the Death Attitude Profile-Revised (DAPR). Analysis of the data involved analysis of covariance (ANCOVA) with the Fisher's Least Significant Difference (LSD) as post-hoc test plus the Pearson correlation. Results: There was a statistical significant difference in spiritual development dimensions and death attitude profile. The results showed that spiritual development were significantly associated with some items of death attitude profiles. Conclusion: Awareness of God was suitable in diabetic patients, but the quality of relationship with God indicated spiritually immature. It is necessary to provide instruction to improve patient's death attitude and following health behavior. PMID:25780376

Educational Video Intervention Effects on Periprocedural Anxiety Levels Among Cardiac Catheterization Patients: A Randomized Clinical Trial.

PubMed

Ayasrah, Shahnaz Mohammed; Ahmad, Muayyad M

2016-01-01

To explore the effectiveness of an educational video intervention in lowering periprocedural anxiety among Jordanian patients hospitalized for cardiac catheterization (CATH). There are many potential reasons of anxiety related to CATH including involvement of the heart and the actual test procedure. A randomized controlled trial took place in a specialized heart institute in Jordan. The sample size was 186 patients who had undergone CATH procedure. Patients anxiety levels were measured by physiological parameters of anxiety (blood pressure, heart rate, and respiratory rate) and by the Spielberger State Anxiety Inventory (SAI). After video education, there was a significant difference in periprocedural perceived anxiety between the groups: preprocedural anxiety levels (M = 39.03, SD = 5.70) for the experimental group versus (M = 49.34, SD = 6.00) for the control, p < .001, and postprocedural perceived anxiety for the experimental group (M = 29.18, SD = 5.42) versus (M = 41.73, SD = 5.41) for the control. Providing an educational video intervention about CATH may effectively decrease periprocedural anxiety levels.

Twelve tips for developing and delivering a massive open online course in medical education.

PubMed

Pickering, James D; Henningsohn, Lars; DeRuiter, Marco C; de Jong, Peter G M; Reinders, Marlies E J

2017-07-01

Massive open online courses (MOOCs) are a novel mode of online learning. They are typically based on higher education courses and can attract a high number of learners, often in the thousands. They are distinct from on-campus education and deliver the learning objectives through a series of short videos, recommended readings and discussion fora, alongside automated assessments. Within medical education the role of MOOCs remains unclear, with recent proposals including continuing professional development, interprofessional education or integration into campus-based blended learning curricula. In this twelve tips article, we aim to provide a framework for readers to use when developing, delivering and evaluating a MOOC within medical education based on the literature and our own experience. Practical advice is provided on how to design the appropriate curriculum, engage with learners on the platform, select suitable assessments, and comprehensively evaluate the impact of your course.

Helminth parasites of Galictis cuja (Carnivora, Mustelidae), from localities in the Atlantic forest of Brazil.

PubMed

Corrêa, Pilar; Bueno, Cecília; Vieira, Fabiano Matos; Muniz-Pereira, Luís Cláudio

2016-01-01

The current study aimed to investigate the helminth parasites of a population of Galictis cuja (Carnivora, Mustelidae) that occur in Atlantic Forest in the Southeastern region of Brazil. We necropsied 18 specimens of G. cuja, collected between January 2009 and May 2014, ran over victims on BR-040 highway, between the municipalities of Duque de Caxias, state of Rio de Janeiro and Juiz de Fora, state of Minas Gerais, localities inserted in Atlantic rainforest Biome. A total of six species of helminths were identified: Dioctophyme renale, Molineus elegans, Physaloptera sp., Strongyloides sp., Platynosomum illiciens, and Pachysentis gethi. Molineus elegans, Physaloptera sp. and P. illiciens were recorded for the first time in this host. Data provided in the current study when compared to the previous reports of parasitism by helminths in G. cuja in Brazil demonstrate that this study is the most representative with this host species.

Development of distortion measurement system for large deployable antenna via photogrammetry in vacuum and cryogenic environment

NASA Astrophysics Data System (ADS)

Zhang, Pengsong; Jiang, Shanping; Yang, Linhua; Zhang, Bolun

2018-01-01

In order to meet the requirement of high precision thermal distortion measurement foraΦ4.2m deployable mesh antenna of satellite in vacuum and cryogenic environment, based on Digital Close-range Photogrammetry and Space Environment Test Technology of Spacecraft, a large scale antenna distortion measurement system under vacuum and cryogenic environment is developed in this paper. The antenna Distortion measurement system (ADMS) is the first domestic independently developed thermal distortion measurement system for large antenna, which has successfully solved non-contact high precision distortion measurement problem in large spacecraft structure under vacuum and cryogenic environment. The measurement accuracy of ADMS is better than 50 μm/5m, which has reached international advanced level. The experimental results show that the measurement system has great advantages in large structural measurement of spacecrafts, and also has broad application prospects in space or other related fields.

Is hydroxyapatite a reliable fixation option in unicompartmental knee arthroplasty? A 5- to 13-year experience with the hydroxyapatite-coated unix prosthesis.

PubMed

Epinette, Jean-Alain; Manley, Michael T

2008-10-01

Hydroxyapatite-coated unicompartmental knee arthroplasty (UKA) is a debatable approach to unicompartmental knee arthritis because UKA isoften viewed as a short-term solution, at best, fora condition that will eventually require a total knee arthroplasty (TKA). Unicompartmental knee arthroplasty is a more technically demanding procedure than TKA, and appropriate patient selection, careful surgical technique, and correct choice of implant geometry are all critical components to its success. A fundamental issue surrounding UKA is whether hydroxyapatite-coated unicompartmental components can provide a long-term solution to unicondylar arthritis. We address this issue in the current study, which is based on a prospective series of 125 hydroxyapatite-coated Unix knee prostheses implanted consecutively between 1994 and 2002, with a 5-year minimum follow-up and a 13-year maximum follow-up. The results of our study indicate that uncemented hydroxyapatite-coated UKA can be successful in the long term.

Pentavalent vaccine and adverse events following immunization-untangling the misinterpretations.

PubMed

Malik, Akash

2014-12-01

In April 2008, the National Technical Group on Immunization (NTAGI) Sub-committee on H. influenza type b (Hib) vaccine recommended that Hib containing pentavalent vaccine should be introduced in the country. Subsequently liquid pentavalent vaccine (LPV) was launched in the Kerala and Tamil Nadu on a pilot basis in December 2011. The introduction of LPV in these two states was followed by reported deaths in infants who had received LPV. An exhaustive summary of media reports and previous literature has since been made available at various fora which have been supplemented with estimations of the damage the LPV may cause. It has thus been concluded that the LPV is bound to cause more number of infant deaths than it will save from Hib meningitis and pneumonia. The current paper aims to clear some of the misinterpretations and miscalculations so that lives of 72,000 infants can be saved.

A review and meta-analysis of corneal cross-linking for post-laser vision correction ectasia.

PubMed

Wan, Qi; Wang, Dan; Ye, HongQuan; Tang, Jing; Han, Yu

2017-09-01

The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery. Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.1 software. The primary outcome parameters included the changes of corrected distant visual acuity (CDVA), uncorrected visual acuity (UCVA), the maximum keratometry value (Kmax) and minimum keratometry value (Kmin), the surface regularity index (SRI), the surface asymmetry index (SAI), the keratoconus prediction index (KPI), corneal thickness, and endothelial cell count. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for absolute changes of the interested outcomes. Seven studies involving 118 patients treated with CXL for progressive ectasia after laser-assisted in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK) (140 eyes; the follow-up time range from 12 to 62 months) were included in the meta-analysis. The pooled results showed that there were no significant differences in Kmax and Kmin values after CXL (WMD = 0.584; 95% CI: -0.289 to 1.458; P  = 0.19; WMD = 0.466; 95% CI: -0.625 to 1.556; P  = 0.403, respectively). The CDVA improved significantly after CXL (WMD = 0.045; 95% CI: 0.010 to 0.079; P  = 0.011), whereas UCVA did not differ statistically (WMD = 0.011; 95% CI: -0.055 to 0.077; P  = 0.746). The changes were not statistically significant in SRI, SAI, and KPI (WMD = 0.116; 95% CI: -0.090 to 0.322; P  = 0.269; WMD = 0.240; 95% CI: -0.200 to 0.681; P  = 0.285; WMD = 0.045; 95% CI: -0.001 to 0.090; P  = 0.056, respectively). Endothelial cell count and corneal thickness did not deteriorate (WMD = 12.634; 95% CI: -29.460 to 54.729; P  = 0.556; WMD = 0.657; 95% CI: -9.402 to 10.717; P  = 0.898, respectively). The study showed that CXL is a

Association between fat mass index and fat-free mass index values and cardiovascular risk in adolescents

PubMed Central

de Oliveira, Patrícia Morais; da Silva, Fabiana Almeida; Oliveira, Renata Maria Souza; Mendes, Larissa Loures; Pereira, Michele; Cândido, Ana Paula Carlos

2016-01-01

Abstract Objective: To describe the association between fat mass index and fat-free mass index values and factors associated with cardiovascular risk in adolescents in the city of Juiz de Fora, Minas Gerais. Methods: Cross-sectional study was with 403 adolescents aged 10–14 years, from public and private schools. Anthropometric, clinical, and biochemical measurements were obtained, as well as self-reported time spent performing physical exercises, sedentary activities and sexual maturation stage. Results: Regarding the nutritional status, 66.5% of the adolescents had normal weight, 19.9% were overweight and 10.2% were obese. For both genders, the fat mass index was higher in adolescents who had high serum triglycerides, body mass index and waist circumference. Conclusions: Adolescents who had anthropometric, clinical and biochemical characteristics considered to be at risk for the development of cardiovascular disease had higher values of fat mass index. Different methodologies for the assessment of body composition make health promotion and disease prevention more effective. PMID:26542380

Asynchronous Distance Education Forum - Brainstorming vs. Snowballing: A Case Study for Teaching in Programming Didactics

NASA Astrophysics Data System (ADS)

Patriarcheas, Kiriakos; Xenos, Michalis

Asynchronous discussion fora all the more become part of the educational process of distance education. The goal of this research is the study of the educational techniques of Brainstorming and Snowballing to their utilisation in the frame of a distance education forum, both as far as participation and creation of learning environment and also educational effectiveness are concerned. This research refers to computer teachers’ training on didactics of programming within the framework of educational micro-worlds. As it is deduced from the data analysis and the study of the messages higher participation and improvement of critical thinking are noted when Brainstorming technique is used, while fairly less time is spent and less off-topic interventions are made when Snowballing technique is used. Meanwhile, Brainstorming is found to be more advantageous than Snowballing concerning the effectiveness both in primary level (trained teachers) and in secondary level of adaptation and knowledge impartment to the students (results of their students).

[Does self-esteem affect body dissatisfaction levels in female adolescents?].

PubMed

Fortes, Leonardo de Sousa; Cipriani, Flávia Marcele; Coelho, Fernanda Dias; Paes, Santiago Tavares; Ferreira, Maria Elisa Caputo

2014-09-01

To evaluate the influence of self-esteem on levels of body dissatisfaction among adolescent females. A group of 397 adolescents aged 12 to 17 years were enrolled in the study. The Body Shape Questionnaire (BSQ) was applied to assess body dissatisfaction. The Rosenberg Self-Esteem Scale was used to assess self-esteem. Weight, height, and skinfold thickness were also measured. These anthropometric data were controlled in the statistical analyses. The multiple regression model indicated influence of "positive self-esteem" (R(2)=0.16; p=0.001) and "negative self-esteem" (R(2)=0.23; p=0.001) subscales on the BSQ scores. Univariate analysis of covariance demonstrated differences in BSQ scores (p=0.001) according to groups of self-esteem. It was concluded that self-esteem influenced body dissatisfaction in adolescent girls from Juiz de Fora, MG. Copyright © 2014 Sociedade de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

The Moderating Influence of International Courts on Social Movements

PubMed Central

Sieder, Rachel

2017-01-01

Abstract Feminists and religious conservatives across the globe have increasingly turned to courts in their battles over abortion. Yet while a significant literature analyzes legal mobilization on abortion issues, it tends to focus predominantly on domestic scenarios. In this article, we consider the effects of this contentious engagement of pro-choice and anti-abortion movements in international human rights fora, asking what happens to social movement claims when they reach international human rights courts. We answer the question through a detailed description of a single case, Gretel Artavia Murillo et al. v. Costa Rica, decided by the Inter-American Court of Human Rights in 2012 but with ongoing repercussions for abortion rights, given its authoritative interpretation of embryonic right to life. Through our analysis of Artavia Murillo, we show how legal mobilization before international human rights courts moderates social movement claims within the legal arena, as rivals respond to one another and argue within the frame of courts’ norms and language. PMID:28630548

The Moderating Influence of International Courts on Social Movements: Evidence from the IVF Case Against Costa Rica.

PubMed

Lemaitre, Julieta; Sieder, Rachel

2017-06-01

Feminists and religious conservatives across the globe have increasingly turned to courts in their battles over abortion. Yet while a significant literature analyzes legal mobilization on abortion issues, it tends to focus predominantly on domestic scenarios. In this article, we consider the effects of this contentious engagement of pro-choice and anti-abortion movements in international human rights fora, asking what happens to social movement claims when they reach international human rights courts. We answer the question through a detailed description of a single case, Gretel Artavia Murillo et al. v. Costa Rica , decided by the Inter-American Court of Human Rights in 2012 but with ongoing repercussions for abortion rights, given its authoritative interpretation of embryonic right to life. Through our analysis of Artavia Murillo , we show how legal mobilization before international human rights courts moderates social movement claims within the legal arena, as rivals respond to one another and argue within the frame of courts' norms and language.

Civil society organizations: capacity to address the needs of the urban poor in Nairobi.

PubMed

Ekirapa, Akaco; Mgomella, George S; Kyobutungi, Catherine

2012-11-01

We conducted a needs assessment that describes the landscape of civil society organizations (CSOs) in three informal settlements around Nairobi, Kenya. The numbers of CSOs have rapidly increased in areas underserved by governments including poor urban neighbourhoods but little is known about CSOs capacity to meet the priority health needs of the urban poor. It is also unclear why, despite a proliferation of CSOs, residents still experience unimproved health outcomes. We collected data on core activities, financial management, and governance structures. Of the 952 CSOs assessed, 47 per cent reported HIV/AIDS counselling, prevention, and treatment as their core activity. Most CSOs reported good financial management systems and governance structures but responses were not validated. Representation in district health stakeholder fora was low; most CSOs did not have the capacity to effectively deliver services that would have impact. For CSOs to realize the desired goal to improve the well-being of low-income populations, programmes to build their management capacity are essential.

Benchmarking progress in tackling the challenges of intellectual property, and access to medicines in developing countries.

PubMed Central

Musungu, Sisule F.

2006-01-01

The impact of intellectual property protection in the pharmaceutical sector on developing countries has been a central issue in the fierce debate during the past 10 years in a number of international fora, particularly the World Trade Organization (WTO) and WHO. The debate centres on whether the intellectual property system is: (1) providing sufficient incentives for research and development into medicines for diseases that disproportionately affect developing countries; and (2) restricting access to existing medicines for these countries. The Doha Declaration was adopted at WTO in 2001 and the Commission on Intellectual Property, Innovation and Public Health was established at WHO in 2004, but their respective contributions to tackling intellectual property-related challenges are disputed. Objective parameters are needed to measure whether a particular series of actions, events, decisions or processes contribute to progress in this area. This article proposes six possible benchmarks for intellectual property-related challenges with regard to the development of medicines and ensuring access to medicines in developing countries. PMID:16710545

Creativity and technical innovation: spatial ability's unique role.

PubMed

Kell, Harrison J; Lubinski, David; Benbow, Camilla P; Steiger, James H

2013-09-01

In the late 1970s, 563 intellectually talented 13-year-olds (identified by the SAT as in the top 0.5% of ability) were assessed on spatial ability. More than 30 years later, the present study evaluated whether spatial ability provided incremental validity (beyond the SAT's mathematical and verbal reasoning subtests) for differentially predicting which of these individuals had patents and three classes of refereed publications. A two-step discriminant-function analysis revealed that the SAT subtests jointly accounted for 10.8% of the variance among these outcomes (p < .01); when spatial ability was added, an additional 7.6% was accounted for--a statistically significant increase (p < .01). The findings indicate that spatial ability has a unique role in the development of creativity, beyond the roles played by the abilities traditionally measured in educational selection, counseling, and industrial-organizational psychology. Spatial ability plays a key and unique role in structuring many important psychological phenomena and should be examined more broadly across the applied and basic psychological sciences.

From concept(ion) to life after death/the grave: The 'natural' history and life cycle(s) of novel psychoactive substances (NPS).

PubMed

Corkery, John Martin; Orsolini, Laura; Papanti, Duccio; Schifano, Fabrizio

2017-05-01

A range of information needs should be met in order to better understand and predict the longevity/existence of novel psychoactive substances (NPS). This conceptual paper argues that one way of assessing how long a molecule may be around is to document how the life cycles or natural histories of 'traditional' drugs and NPS evolve. The earliest indication of the possible appearance of a new substance might be evidenced on the DeepWeb. However, this means they are less visible, in line with the clandestine nature of drug use and supply. Therefore, monitoring discussion groups/fora needs the development of new methods compared to those used in the Surface Net. Issues needing consideration in establishing NPS life cycles are outlined here, together with the probable outcomes that could result. The approach advocated means that it should be easier to identify which NPS are likely to come up or are emerging in real time, and, therefore, pre-empt/prevent their supply. Copyright © 2017 John Wiley & Sons, Ltd.

Joint Atomic Information Exchange Group information management project. Briefing outlining functions and specifications of JAIEG automated information management system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, M.G.

1983-07-20

The Joint Atomic Information Exchange Group (JAIEG) was formed in 1959. JAIEG's charter was to be the agent to determine the transmissibility of atomic information to foreign governments or regional defense organizations. JAIEG, operating from the joint policy direction of the Deputy Assistant Secretary for Military Application under the Department of Energy and of the Assistant to the Secretary of Defense for Atomic Energy under the Department of Defense, determines in a uniform and consistent manner the transmissibility of Restricted Data (RD) and Formerly Restricted Data (FRD). JAIEG also maintains records of all transmittal of such data, and maintains recordmore » copies of all information reviewed. This information exists only on paper and must be processed manually. JAIEG's work load has grown continuously with the size of its filing system. This has prompted an investigation of the potential benefits of automating JAIEG activities. Science Applications, Inc. (SAI) has studied JAIEG procedures and has identified several areas where JAIEG information processing activities can be automated to achieve greater system efficiency.« less

Two-Step Optimization for Spatial Accessibility Improvement: A Case Study of Health Care Planning in Rural China

PubMed Central

Luo, Jing; Tian, Lingling; Luo, Lei; Yi, Hong

2017-01-01

A recent advancement in location-allocation modeling formulates a two-step approach to a new problem of minimizing disparity of spatial accessibility. Our field work in a health care planning project in a rural county in China indicated that residents valued distance or travel time from the nearest hospital foremost and then considered quality of care including less waiting time as a secondary desirability. Based on the case study, this paper further clarifies the sequential decision-making approach, termed “two-step optimization for spatial accessibility improvement (2SO4SAI).” The first step is to find the best locations to site new facilities by emphasizing accessibility as proximity to the nearest facilities with several alternative objectives under consideration. The second step adjusts the capacities of facilities for minimal inequality in accessibility, where the measure of accessibility accounts for the match ratio of supply and demand and complex spatial interaction between them. The case study illustrates how the two-step optimization method improves both aspects of spatial accessibility for health care access in rural China. PMID:28484707

Two-Step Optimization for Spatial Accessibility Improvement: A Case Study of Health Care Planning in Rural China.

PubMed

Luo, Jing; Tian, Lingling; Luo, Lei; Yi, Hong; Wang, Fahui

2017-01-01

A recent advancement in location-allocation modeling formulates a two-step approach to a new problem of minimizing disparity of spatial accessibility. Our field work in a health care planning project in a rural county in China indicated that residents valued distance or travel time from the nearest hospital foremost and then considered quality of care including less waiting time as a secondary desirability. Based on the case study, this paper further clarifies the sequential decision-making approach, termed "two-step optimization for spatial accessibility improvement (2SO4SAI)." The first step is to find the best locations to site new facilities by emphasizing accessibility as proximity to the nearest facilities with several alternative objectives under consideration. The second step adjusts the capacities of facilities for minimal inequality in accessibility, where the measure of accessibility accounts for the match ratio of supply and demand and complex spatial interaction between them. The case study illustrates how the two-step optimization method improves both aspects of spatial accessibility for health care access in rural China.

The PHEMU15 catalogue and astrometric results of the Jupiter's Galilean satellite mutual occultation and eclipse observations made in 2014-2015

NASA Astrophysics Data System (ADS)

Saquet, E.; Emelyanov, N.; Robert, V.; Arlot, J.-E.; Anbazhagan, P.; Baillié, K.; Bardecker, J.; Berezhnoy, A. A.; Bretton, M.; Campos, F.; Capannoli, L.; Carry, B.; Castet, M.; Charbonnier, Y.; Chernikov, M. M.; Christou, A.; Colas, F.; Coliac, J.-F.; Dangl, G.; Dechambre, O.; Delcroix, M.; Dias-Oliveira, A.; Drillaud, C.; Duchemin, Y.; Dunford, R.; Dupouy, P.; Ellington, C.; Fabre, P.; Filippov, V. A.; Finnegan, J.; Foglia, S.; Font, D.; Gaillard, B.; Galli, G.; Garlitz, J.; Gasmi, A.; Gaspar, H. S.; Gault, D.; Gazeas, K.; George, T.; Gorda, S. Y.; Gorshanov, D. L.; Gualdoni, C.; Guhl, K.; Halir, K.; Hanna, W.; Henry, X.; Herald, D.; Houdin, G.; Ito, Y.; Izmailov, I. S.; Jacobsen, J.; Jones, A.; Kamoun, S.; Kardasis, E.; Karimov, A. M.; Khovritchev, M. Y.; Kulikova, A. M.; Laborde, J.; Lainey, V.; Lavayssiere, M.; Le Guen, P.; Leroy, A.; Loader, B.; Lopez, O. C.; Lyashenko, A. Y.; Lyssenko, P. G.; Machado, D. I.; Maigurova, N.; Manek, J.; Marchini, A.; Midavaine, T.; Montier, J.; Morgado, B. E.; Naumov, K. N.; Nedelcu, A.; Newman, J.; Ohlert, J. M.; Oksanen, A.; Pavlov, H.; Petrescu, E.; Pomazan, A.; Popescu, M.; Pratt, A.; Raskhozhev, V. N.; Resch, J.-M.; Robilliard, D.; Roschina, E.; Rothenberg, E.; Rottenborn, M.; Rusov, S. A.; Saby, F.; Saya, L. F.; Selvakumar, G.; Signoret, F.; Slesarenko, V. Y.; Sokov, E. N.; Soldateschi, J.; Sonka, A.; Soulie, G.; Talbot, J.; Tejfel, V. G.; Thuillot, W.; Timerson, B.; Toma, R.; Torsellini, S.; Trabuco, L. L.; Traverse, P.; Tsamis, V.; Unwin, M.; Abbeel, F. Van Den; Vandenbruaene, H.; Vasundhara, R.; Velikodsky, Y. I.; Vienne, A.; Vilar, J.; Vugnon, J.-M.; Wuensche, N.; Zeleny, P.

2018-03-01

During the 2014-2015 mutual events season, the Institut de Mécanique Céleste et de Calcul des Éphémérides (IMCCE), Paris, France, and the Sternberg Astronomical Institute (SAI), Moscow, Russia, led an international observation campaign to record ground-based photometric observations of Galilean moon mutual occultations and eclipses. We focused on processing the complete photometric observations data base to compute new accurate astrometric positions. We used our method to derive astrometric positions from the light curves of the events. We developed an accurate photometric model of mutual occultations and eclipses, while correcting for the satellite albedos, Hapke's light scattering law, the phase effect, and the limb darkening. We processed 609 light curves, and we compared the observed positions of the satellites with the theoretical positions from IMCCE NOE-5-2010-GAL satellite ephemerides and INPOP13c planetary ephemeris. The standard deviation after fitting the light curve in equatorial positions is ±24 mas, or 75 km at Jupiter. The rms (O-C) in equatorial positions is ±50 mas, or 150 km at Jupiter.

IAI Capacity Building Activities in the Americas: Fostering Multinational and Multidisciplinary Research

NASA Astrophysics Data System (ADS)

Ohira, M. S.

2007-05-01

The IAI's Training and Education (T&E) activities are designed to encourage capacity building in the Americas and are developed within and in parallel with the IAI research programs in global environmental change (GEC). The IAI has various training priorities: (1) support for graduate students in the form of fellowships through research programs; (2) development of IAI Training Institutes in Interdisciplinary Sciences and Science-Policy Fora; and (3) support for technical workshops, scientific meetings, and seminars. It becomes increasingly evident that institutions such as IAI must provide training and support to policy and decision makers who deal with environmental issues. The IAI Training Institutes emphasize an exchange of information about the various scientific languages, needs, and methodologies of disciplines that study GEC. Particular attention is given to socio-economic impacts and ways in which nations can gain a better understanding of the complex mechanisms, degrees of change, causes, and consequences - and therefore, plan sound public and private policies to minimize problems and maximize opportunities. The IAI has also implemented a Training Institute Seed Grant (TISG) Program as an assessment activity of the Training Institutes to further encourage network building and multinational and multidisciplinary collaboration among its 19 member countries in the Americas. By fostering the development of such new multidisciplinary, multinational teams, the IAI ensures a future generation of professionals who will be engaged in IAI research programs and networks and will lead the integrated science programs in the next decades. Furthermore, IAI has organized Science-Policy Fora, which focus on the science- policy interface and ways to incorporate scientific information into policy and decision-making processes. Participants discussed what scientific information is available, what aspects need to be better understood, translation of scientific information for

Unifying theory for terrestrial research infrastructures

NASA Astrophysics Data System (ADS)

Mirtl, Michael

2016-04-01

The presentation will elaborate on basic steps needed for building a common theoretical base between Research Infrastructures focusing on terrestrial ecosystems. This theoretical base is needed for developing a better cooperation and integrating in the near future. An overview of different theories will be given and ways to a unifying approach explored. In the second step more practical implications of a theory-guided integration will be developed alongside the following guiding questions: • How do the existing and planned European environmental RIs map on a possible unifying theory on terrestrial ecosystems (covered structures and functions, scale; overlaps and gaps) • Can a unifying theory improve the consistent definition of RÍs scientific scope and focal science questions? • How could a division of tasks between RIs be organized in order to minimize parallel efforts? • Where concretely do existing and planned European environmental RIs need to interact to respond to overarching questions (top down component)? • What practical fora and mechanisms (across RIs) would be needed to bridge the gap between PI driven (bottom up) efforts and the centralistic RI design and operations?

The right to enjoy the benefits of scientific progress: in search of state obligations in relation to health.

PubMed

Donders, Yvonne

2011-11-01

After having received little attention over the past decades, one of the least known human rights--the right to enjoy the benefits of scientific progress and its applications--has had its dust blown off. Although included in the Universal Declaration of Human Rights (UDHR) and in the International Covenant on Economic, Social and Cultural Rights (ICESCR)--be it at the very end of both instruments -this right hardly received any attention from States, UN bodies and programmes and academics. The role of science in societies and its benefits and potential danger were discussed in various international fora, but hardly ever in a human rights context. Nowadays, within a world that is increasingly turning to science and technology for solutions to persistent socio-economic and development problems, the human dimension of science also receives increased attention, including the human right to enjoy the benefits of scientific progress and its applications. This contribution analyses the possible legal obligations of States in relation to the right to enjoy the benefits of scientific progress and its applications, in particular as regards health.

Physaloptera bainae n. sp. (Nematoda: Physalopteridae) parasitic in Salvator merianae (Squamata: Teiidae), with a key to Physaloptera species parasitizing reptiles from Brazil.

PubMed

Pereira, Felipe B; Alves, Philippe V; Rocha, Bárbara M; de Souza Lima, Sueli; Luque, José L

2014-04-01

Physaloptera bainae n. sp. (Nematoda: Physalopteridae) from stomach of the large "tegú" lizard Salvator merianae (Squamata: Teiidae), collected in an ecological park that is part of the Atlantic Rainforest biome in Juiz de Fora, Minas Gerais, Brazil, is described. The new species which has females with didelphic uterus, is the only species of the genus exhibiting external teeth in the form of 4 spines that are organized in a cross-shaped pattern at the anterior apical end, with 2 minute adcloacal papillae on the anterior part of cloacal aperture in males and a large cuticular expansion at the anterior end of females. Moreover, P. bainae n. sp. can be differentiated from the other congeners by the combination of other features, e.g., number (23) and pattern of caudal papillae, spicule size (left 554-600; right 589-617) and vulval position (on the first third of body), and because the specimens are particularly large and robust. Physaloptera monodens is considered a junior synonym of P. obtusissima. In addition, a key to Physaloptera species parasitizing reptiles from Brazil is provided.

Book Review: Book review

NASA Astrophysics Data System (ADS)

Velasco, Josefa Ros

2015-11-01

Alberto Fragio is currently one of the major experts on Hans Blumenberg's work and thought. In recent years he has become a great interpreter of Blumenberg's posthumous publications and his Nachlaβ at the Deutsche Literatur-Archiv Marbach (DLA Marbach). Since he acquired his doctoral degree in 2007, Fragio has devoted much of his efforts to clarifying Blumenberg's convoluted philosophical corpus, whose understanding - as is known - is really demanding for anyone who ventures into its disclosure, and it requires a monumental exercise of patience. Fragio has published far more than a dozen academic articles and three monographs, all of them generally pointing to the existence of a holistic nature in the philosophical work to which Blumenberg devoted a lifetime. Although his research project was on Blumenberg's History and Philosophy of Science, his joint publication with Giordano Bruno, Hans Blumenberg, Nuovi paradigmi d'analisi(2010), and the publication of what is the first enquiry into Blumenberg's History of Astronomy, Destrucción, cosmos, metáfora. Ensayos sobre HansBlumenberg (2010),

Integrated care networks and quality of life: linking research and practice

PubMed Central

Warner, Morton; Gould, Nicholas

2003-01-01

Abstract Purpose To report on the development of a project dedicated to improving the quality of life of older people through the creation of integrated networks. Context The project is set within a post-industrial community and against a backdrop of government re-organisation and devolution within Wales. The immediate research context is determined by utilising an approach to the structure of integration derived theoretically. Case description Project CHAIN (Community Health Alliances through Integrated Networks) adopts a network perspective as a means of addressing both the determinants of health and service delivery in health and social care. The Project partners are: healthcare commissioners and providers; local authority directorates including community services and transportation; the voluntary and private sectors; and a university institute. Co-opted participants include fora representing older people's interests. Data sources The Project incorporates an action research method. This paper highlights qualitative data elicited from interviews with health and social care managers and practitioners. Conclusions and discussion The Project is ongoing and we record progress in building five integrated networks. PMID:16896421

Near-Infrared Spectroscopy and Spectral Mapping of Jupiter and the Galilean Satellites: Results from Galileo's Initial Orbit

NASA Technical Reports Server (NTRS)

Carlson, R.; Smythe, W.; Baines, K.; Barbinis, E.; Becker, K.; Burns, R.; Calcutt, S.; Calvin, W.; Clark, R.; Danielson, G.;

A LEGISLATIVE CASE STUDY OF THE EVOLUTION OF POLYVICTIMIZATION RESEARCH AND POLICY IMPLEMENTATION: MENTAL HEALTH PROFESSIONALS’ DUTY TO ENGAGE IN PUBLIC POLICY ADVOCACY

PubMed Central

Culyba, Alison Journey; Patton, William Wesley

2017-01-01

One reason that scientific research takes so long to reach patients is that medical researchers and practitioners often lack training in public policy implementation theory and strategy. General medical and specific psychiatric ethical precepts in the United States and in international ethics codes invest public policy duties in psychiatric researchers and individual clinicians. This essay discusses those medical ethical rules and suggests means for training psychiatrists to meet their public health policy duties in legal fora. The discussion presents a case study of the evolution of polyvictimization research, its initial lack of implementation in clinical practice and public policy debates, and a detailed demonstration of the incorporation of polyvictimization research in informing legislative action. Through systematic efforts to expand training and involvement of psychiatrists, we can expedite the implementation of psychiatric research by marshalling individual psychiatrists to affect decisions in legislative, executive, and judicial proceedings. These individual efforts can occur synergistically with ongoing psychiatric and psychological organizations’ efforts to better effect timely incorporation of evidence-based policies to improve mental health at the local, state, national, and international levels. PMID:28758050

Healthy ageing supported by technology--a cross-disciplinary research challenge.

PubMed

Koch, Sabine

2010-01-01

During the last decade, the challenges of an ageing society became focus for extensive scientific, public and political discussions. From discussions in scientific fora within each discipline, there is now a shift towards cross-disciplinary scientific approaches. The aim of this article is therefore, to collect and describe different scientific viewpoints in this regard and to point out research gaps to be addressed in the future. The article is based on a number of review articles and keynote lectures given by the author, and complemented with informal interviews of experts from different scientific fields engaged in the field of technology and ageing. Results show that research has emerged from being technology-focussed to scenario-based taking different scientific perspectives into account. However, the biggest challenge still is to accommodate the need for a holistic integrated service which means to provide personalised services and adapt technology and content to individual needs of different stakeholders. Further, cross-disciplinary research is needed that relates informatics and technology to different stages of the aging process and that evaluates the effects of proposed technical solutions.

Prognostic Effect of Low Subcutaneous Adipose Tissue on Survival Outcome in Patients With Multiple Myeloma.

PubMed

Takeoka, Yasunobu; Sakatoku, Kazuki; Miura, Akiko; Yamamura, Ryosuke; Araki, Taku; Seura, Hirotaka; Okamura, Terue; Koh, Hideo; Nakamae, Hirohisa; Hino, Masayuki; Ohta, Kensuke

2016-08-01

Increasing evidence suggests that decreased skeletal muscle mass (sarcopenia) or adipose tissue assessed using computed tomography (CT) predicts negative outcomes in patients with solid tumors. However, the prognostic value of such an assessment in multiple myeloma (MM) remains unknown. Consecutive patients with newly diagnosed symptomatic MM were retrospectively analyzed. The cross-sectional area of skeletal muscles and subcutaneous or visceral adipose tissue was measured using CT. Body composition indexes (skeletal muscle index, subcutaneous adipose tissue index [SAI], and visceral adipose tissue index) were calculated. The association between these indexes and overall survival (OS) was examined. Of 56 evaluable patients, 37 (66%) had sarcopenia. The 2-year OS in patients with SAI < median was 58% compared with 91% in those with SAI ≥ median (P = .006). In multivariate analyses, SAI < median was significantly associated with poor OS (hazard ratio, 4.05; P = .02). Sarcopenia was not associated with OS. The maximum value of the standardized uptake value was significantly higher in patients with SAI < median (P = .02). The findings of this study suggest that low subcutaneous adipose tissue at baseline predicts poor survival outcome in patients with MM. Copyright © 2016 Elsevier Inc. All rights reserved.

The effects of reflexology on anxiety and pain in patients after abdominal hysterectomy: A randomised controlled trial.

PubMed

Öztürk, Ruşen; Sevil, Ümran; Sargin, Asuman; Yücebilgin, M Sait

2018-02-01

This study aimed at finding out the effects of reflexology on pain, anxiety levels after abdominal hysterectomy. The study was performed on women hospitalized in the intensive care unit and gynecology services of Ege University Hospital in İzmir after abdominal hysterectomy between September 2013 and September 2014. This study was designed and conducted as a randomized controlled trial. The study sample consisted of 63 female patients: 32 in the experimental group and 31 in the control group. The postoperative daily monitoring sheet, Spielberger State Anxiety Inventory (SAI), was employed to collect research data and "visual analog scale" to evaluate pain levels. The female patients' average age was found to be 47.23 ± 4.71. The three-day monitoring showed a significant difference between the experimental and control groups in terms of average pain levels and anxiety scores after reflexology (p < 0.05). Foot reflexology may serve as an effective nursing intervention to increase the well-being and decrease the pain of female patients after abdominal hysterectomy, and nurses should be aware of the benefits of reflexology. Copyright © 2017 Elsevier Ltd. All rights reserved.

Spacecraft contamination programs within the Air Force Systems Command Laboratories

NASA Technical Reports Server (NTRS)

Murad, Edmond

1990-01-01

Spacecraft contamination programs exist in five independent AFSC organizations: Geophysics Laboratory (GL), Arnold Engineering and Development Center (AEDC), Rome Air Development Center (RADC/OSCE), Wright Research and Development Center (MLBT), Armament Laboratory (ATL/SAI), and Space Systems Division (SSD/OL-AW). In addition, a sizable program exists at Aerospace Corp. These programs are complementary, each effort addressing a specific area of expertise: GL's effort is aimed at addressing the effects of on-orbit contamination; AEDC's effort is aimed at ground simulation and measurement of optical contamination; RADC's effort addresses the accumulation, measurement, and removal of contamination on large optics; MLBT's effort is aimed at understanding the effect of contamination on materials; ATL's effort is aimed at understanding the effect of plume contamination on systems; SSD's effort is confined to the integration of some contamination experiments sponsored by SSD/CLT; and Aerospace Corp.'s effort is aimed at supporting the needs of the using System Program Offices (SPO) in specific areas, such as contamination during ground handling, ascent phase, laboratory measurements aimed at understanding on-orbit contamination, and mass loss and mass gain in on-orbit operations. These programs are described in some detail, with emphasis on GL's program.

Degradation of FEP thermal control materials returned from the Hubble Space Telescope

NASA Technical Reports Server (NTRS)

Zuby, Thomas M.; Degroh, Kim K.; Smith, Daniela C.

1995-01-01

After an initial 3.6 years of space flight, the Hubble Space Telescope was serviced through a joint effort with the NASA and the European Space Agency. Multi-layer insulation (MLI) was retrieved from the electronics boxes of the two magnetic sensing systems (MSS), also called the magnetometers, and from the returned solar array (SA-I) drive arm assembly. The top layer of each MLI assembly is fluorinated ethylene propylene (FEP, a type of Teflon). Dramatic changes in material properties were observed when comparing areas of high solar fluence to areas of low solar fluence. Cross sectional analysis shows atomic oxygen (AO) erosion values up to 25.4 mu m (1 mil). Greater occurrences of through-thickness cracking and surface microcracking were observed in areas of high solar exposure. Atomic force microscopy (AFM) showed increases in surface microhardness measurements with increasing solar exposure. Decreases in FEP tensile strength and elongation were measured when compared to non-flight material. Erosion yield and tensile results are compared with FEP data from the Long Duration Exposure Facility. AO erosion yield data, solar fluence values, contamination, micrometeoroid or debris impact sites, and optical properties are presented.

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves.

PubMed

Fonseca, Aldilane Gonçalves; Ribeiro Dantas, Luzia Leiros Sena Fernandes; Fernandes, Júlia Morais; Zucolotto, Silvana Maria; Lima, Adley Antoninni Neves; Soares, Luiz Alberto Lira; Rocha, Hugo Alexandre Oliveira; Lemos, Telma Maria Araújo Moura

2018-01-01

The species Kalanchoe brasiliensis , known as "Saião , " has anti-inflammatory, antimicrobial, and antihistamine activities. It also has the quercetin and kaempferol flavonoids, which exert their therapeutic activities. With extensive popular use besides the defined therapeutical properties, the study of possible side effects is indispensable. The objective of this study is to evaluate the toxicity in vitro and in vivo from the hydroethanolic extract of the leaves of K. brasiliensis . The action of the extract (concentrations from 0.1 to 1000 uL/100 uL) in normal and tumor cells was evaluated using the MTT method. Acute toxicity and subchronic toxicity were evaluated in mice with doses of 250 to 1000 mg/kg orally, following recognized protocols. The in vitro results indicated cytotoxic activity for 3T3 cell line (normal) and 786-0 (kidney carcinoma), showing the activity to be concentration-dependent, reaching 92.23% cell inhibition. In vivo , the extract showed no significant toxicity; only liver changes related to acute toxicity and some signs of liver damage, combining biochemical and histological data. In general, the extract showed low or no toxicity, introducing itself as safe for use with promising therapeutic potential.

Deformation style of the Mesozoic sedimentary rocks in southern Thailand

NASA Astrophysics Data System (ADS)

Kanjanapayont, Pitsanupong

2014-10-01

Mesozoic sedimentary rocks in southern Thailand are widespread from NNE-SSW and N-S in Chumphon and Trang provinces. The Mesozoic stratigraphic units are the marine Triassic Sai Bon Formation and the non-marine Jurassic-Cretaceous Thung Yai Group, the latter subdivided into Khlong Min, Lam Thap, Sam Chom, and Phun Phin Formations. These units overlie Permian carbonate rocks with an angular unconformity, and are overlain unconformably by Cenozoic units and the Quaternary sediments. The Mesozoic rocks have been folded to form two huge first-ordered syncline or synclinoria, the Chumphon and Surat Thani-Krabi-Trang synclinoria. These synclinoria are elongated in NNE-SSW to N-S direction, and incorporate asymmetric lower-order parasitic folds. The folds have moderately to steeply dipping eastward limbs and more gently dipping westward limbs. These folds were transected by brittle fractures in four major directions. These geologic structures indicate WNW-ESE to E-W contraction with top-to-the-east simple shear at some time before the deposition of the Cenozoic sedimentary units. No major deformation has affected the rocks subsequently, apart from the formation of the fault-controlled Cenozoic basins.

Calibração do sistema imageador do telescópio MASCO

NASA Astrophysics Data System (ADS)

Mejía, J.; D'Amico, F.; Villela, T.; Braga, J.

2003-08-01

O MASCO (MÁScara COdificada) é um telescópio imageador de raios-X e gama atualmente configurado para operar na faixa de 50 a 600 keV com uma resolução angular de 14 minutos de arco num campo de visada total circular de 23,5° de diâmetro. O MASCO está totalmente operacional e deverá ser lançado em um balão estratosférico no segundo semestre de 2003 para realizar observações durante ~20 horas a ~40 km de altitude. O telescópio utiliza uma máscara codificada de padrão uniformemente redundante modificado (MURA) de dimensões 19 ´ 19. Esse padrão pertence a uma subclasse de MURAs que apresenta anti-simetria de 90° e conseqüentemente permite a utilização da técnica de subtração de variações sistemáticas de ruído de fundo através de utilização da configuração anti-máscara, obtida com uma simples rotação da máscara. Neste trabalho apresentamos resultados de calibrações em laboratório que tiveram como objetivo testar o sistema imageador. Imagens de fontes radioativas foram obtidas com o telescópio em configuração de vôo, com a máscara girando. Serão discutidos os resultados desses testes e as técnicas desenvolvidas para eliminar ambigüidades de posição de fontes, otimização da relação sinal-ruído e observação de fontes fora do campo totalmente codificado. O sistema de máscara/antimáscara mostrou-se capaz de aumentar a relação sinal-ruído de ~60% para fontes intensas (100 s). Com a máscara girando, a técnica de reconstrução de imagens desenvolvida identificou a posição exata da fonte e não introduziu perda de sensibilidade. Imagens de uma fonte colocada a 8,3° - fora do campo totalmente codificado do telescópio -, mostraram uma diminuição de ~40% na relação sinal/ruído em relação ao centro do campo de visada, o que se deve à codificação incompleta pela máscara e à absorção parcial do fluxo pelos detectores de blindagem.

Efeitos dos sais na planta e tolerância das culturas à salinidade (Salinity effects on plants and tolerance of crops to salinity)

USDA-ARS?s Scientific Manuscript database

The major challenge for world agriculture today is to maintain food and water supplies that can meet the demands of a growing world population. The shortage of fresh water, and its use mainly for human consumption, leaves the farmers with the choice of using reclycled city water, or underground sali...

THE AGES OF BOMA MIGMATITES AND OF THE WEST CONGOLIAN OROGENY. PRELIMINARY DATA ON THE AGES OF THE MAYUMBIAN AND AN EARLIER FORMATION (in French)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cahen, L.; Delhal, J.; Ledent, D.

1963-08-01

The oldest, (2760 plus or minus 500) million years or older, is interpreted as representing an episode of an orogenic cycle, older than the Mayumbian orogeny. The next event, also only approximately dated between 1480 and 1800 million years is the Mayumbian orogeny. The last major event, of which a late tectonic phase is circa 615 million years old, is the West-Congolian orogeny which is followed by posttectonic pegmatites and veins spanning the interval between 520 (pegmatites) to circa 445 (last veins) million years. Numerous biotites have, by both the Rb--Sr and the K--Ar method, yielded apparent ages similar tomore » those of the last post-tectonic veins, though their true age be certainly older. This is also the case for-a K--Ar age on microcline. These results indicate that these apparent ages on biotite and microcline are probably caused by a post-tectonic hydrothermal event and/or by the uplift which took place at the same time, after the West Congolian folding. It therefore follows that low Rb-- Sr apparent ages on biotites are not necessarily caused by superimposed tectonics or by an important metamorphism. (auth)« less

Application configuration selection for energy-efficient execution on multicore systems

DOE PAGES

Wang, Shinan; Luo, Bing; Shi, Weisong; ...

2015-09-21

Balanced performance and energy consumption are incorporated in the design of modern computer systems. Several runtime factors, such as concurrency levels, thread mapping strategies, and dynamic voltage and frequency scaling (DVFS) should be considered in order to achieve optimal energy efficiency fora workload. Selecting appropriate run-time factors, however, is one of the most challenging tasks because the run-time factors are architecture-specific and workload-specific. And while most existing works concentrate on either static analysis of the workload or run-time prediction results, we present a hybrid two-step method that utilizes concurrency levels and DVFS settings to achieve the energy efficiency configuration formore » a worldoad. The experimental results based on a Xeon E5620 server with NPB and PARSEC benchmark suites show that the model is able to predict the energy efficient configuration accurately. On average, an additional 10% EDP (Energy Delay Product) saving is obtained by using run-time DVFS for the entire system. An off-line optimal solution is used to compare with the proposed scheme. Finally, the experimental results show that the average extra EDP saved by the optimal solution is within 5% on selective parallel benchmarks.« less

Winners and losers in a world where the high seas is closed to fishing

PubMed Central

Sumaila, U. Rashid; Lam, Vicky W. Y.; Miller, Dana D.; Teh, Louise; Watson, Reg A.; Zeller, Dirk; Cheung, William W. L.; Côté, Isabelle M.; Rogers, Alex D.; Roberts, Callum; Sala, Enric; Pauly, Daniel

2015-01-01

Fishing takes place in the high seas and Exclusive Economic Zones (EEZs) of maritime countries. Closing the former to fishing has recently been proposed in the literature and is currently an issue of debate in various international fora. We determine the degree of overlap between fish caught in these two areas of the ocean, examine how global catch might change if catches of straddling species or taxon groups increase within EEZs as a result of protection of adjacent high seas; and identify countries that are likely to gain or lose in total catch quantity and value following high-seas closure. We find that <0.01% of the quantity and value of commercial fish taxa are obtained from catch taken exclusively in the high seas, and if the catch of straddling taxa increases by 18% on average following closure because of spillover, there would be no loss in global catch. The Gini coefficient, which measures income inequality, would decrease from 0.66 to 0.33. Thus, closing the high seas could be catch-neutral while inequality in the distribution of fisheries benefits among the world's maritime countries could be reduced by 50%. PMID:25674681

The European politics of animal experimentation: From Victorian Britain to 'Stop Vivisection'.

PubMed

Germain, Pierre-Luc; Chiapperino, Luca; Testa, Giuseppe

2017-08-01

This paper identifies a common political struggle behind debates on the validity and permissibility of animal experimentation, through an analysis of two recent European case studies: the Italian implementation of the European Directive 2010/63/EC regulating the use of animals in science, and the recent European Citizens' Initiative (ECI) 'Stop Vivisection'. Drawing from a historical parallel with Victorian antivivisectionism, we highlight important threads in our case studies that mark the often neglected specificities of debates on animal experimentation. From the representation of the sadistic scientist in the XIX century, to his/her claimed capture by vested interests and evasion of public scrutiny in the contemporary cases, we show that animals are not simply the focus of the debate, but also a privileged locus at which much broader issues are being raised about science, its authority, accountability and potential misalignment with public interest. By highlighting this common socio-political conflict underlying public controversies around animal experimentation, our work prompts the exploration of modes of authority and argumentation that, in establishing the usefulness of animals in science, avoid reenacting the traditional divide between epistemic and political fora. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

"Spice," "kryptonite," "black mamba": an overview of brand names and marketing strategies of novel psychoactive substances on the web.

PubMed

Corazza, Ornella; Valeriani, Giuseppe; Bersani, Francesco Saverio; Corkery, John; Martinotti, Giovanni; Bersani, Giuseppe; Schifano, Fabrizio

2014-01-01

Abstract Introduction: Novel Psychoactive Substances (NPSs) are often sold online as "legal" and "safer" alternatives to International Controlled Drugs (ICDs) with captivating marketing strategies. Our aim was to review and summarize such strategies in terms of the appearance of the products, the brand names, and the latest trends in the illicit online marketplaces. Scientific data were searched in PsychInfo and Pubmed databases; results were integrated with an extensive monitoring of Internet (websites, online shops, chat rooms, fora, social networks) and media sources in nine languages (English, French, Farsi, Portuguese, Arabic, Russian, Spanish, and Chinese simplified/traditional) available from secure databases of the Global Public Health Intelligence Network. Evolving strategies for the online diffusion and the retail of NPSs have been identified, including discounts and periodic offers on chosen products. Advertisements and new brand names have been designed to attract customers, especially young people. An increased number of retailers have been recorded as well as new Web platforms and privacy systems. NPSs represent an unprecedented challenge in the field of public health with social, cultural, legal, and political implications. Web monitoring activities are essential for mapping the diffusion of NPSs and for supporting innovative Web-based prevention programmes.

"Marvin, the Paranoid Android": The Case of an Alpha-PVP User in the Expanding Galaxy of NPS.

PubMed

Pierluigi, Simonato; Laura, Bulsis; Attilio, Negri; Gurjeet K, Bansal; Gloria, Pessa; Davide, Mioni; Borgherini, Giuseppe; Giovanni, Martinotti; Fabrizio, Schifano; Perini, Giulia; Ornella, Corazza

2018-05-16

Alpha-PVP can be defined as a novel psychoactive substance (NPS)-more specifically, a novel synthetic cathinone with unpredictable stimulant effects in humans. "Marvin" arrived at a Dual Diagnosis Unit at Parco dei Tigli, Italy. He underwent a 30-day rehabilitation program to overcome his problematic Alpha-PVP use as a psychonaut. We conducted an online search to understand the properties of Alpha-PVP and its presence in scientific literature, reviewing official reports and the online drug market (e.g., fora, webpages). In the Dual Diagnosis Unit, Marvin completed the 30-day rehabilitation program that included assessments and group and individual cognitive behavioral therapy. Alpha-PVP is a synthetic cathinone with stimulant properties, available in the online market but with unpredictable effects in humans. The present case reports an important risk of psychosis in a psychonaut patient who arrived and declared its intense use before admission to our Unit. This article describes the psychopathological effects of the novel compound Alpha-PVP in a psychonaut patient. Patients attending clinics that have used Alpha-PVP pose a new challenge for traditional services of mental health and addiction.

Early Detection of Pancreatic Cancer: The Role of Industry in the Development of Biomarkers.

PubMed

Kenner, Barbara J; Go, Vay Liang W; Chari, Suresh T; Goldberg, Ann E; Rothschild, Laura J

A diagnosis of pancreatic cancer is devastating owing to its poor prognosis, with a 5-year survival rate of only 9%. Currently, most individuals are diagnosed at a late stage when treatment options are limited. Early detection of pancreatic cancer provides the greatest hope for making substantial improvements in survival. The Kenner Family Research Fund in partnership with the American Pancreatic Association has sponsored a series of fora to stimulate discussion and collaboration on early detection of pancreatic cancer. At the first forum in 2014, "Early Detection of Sporadic Pancreatic Cancer Summit Conference," a strategic plan was set forth by an international group of interdisciplinary scientific representatives and subsequently The Strategic Map for Innovation was generated. The current conference report is the third forum in the series, "Early Detection of Pancreatic Cancer: The Role of Industry in the Development of Biomarkers," which was held in Boston, Massachusetts, on October 27, 2016. This report provides an overview of examples of innovative initiatives by industry and confirms the critical need for collaboration among industry, government, research institutions, and advocacy groups in order to make pancreatic cancer more easily detectable in its earlier stages, when it is more treatable.

The post-evaluation of green residential building in Ningxia

NASA Astrophysics Data System (ADS)

Wu, Yunna; Wang, Zhen

2017-06-01

Green residential buildings are concerned by more and more people. However, the development of green residential buildings has been limited due to the single-standard requirements and lack of the multi-objective performance. At same time, the evaluation criteria system of green residential building is not comprehensive enough. So first of all, using SPSS software, residents questionnaire surveys are figured and found that the judge of experts and residents about the green elements is inconsistent, so the owners’ satisfaction is included in the post-evaluation criterial systems of green residential building from five aspects-the preliminary work of construction, construction process, economic, social benefits and owners satisfaction in Ningxia area, combined with expert interviews. Secondly, in the post-evaluation, it is difficult for many experts judgment matrix to meet the requirement of consistency, in this paper using MATLAB program, judgment matrix consistency is adjusted. And the weights of the criteria and sub-criteria and experts weights using group AHP method are determined. Finally, the grey clustering method is used to establish the post-evaluation model and the real case of Sai-shang project is carried out. It shows that the result obtained by using the improved criteria system and method in this paper is in a high degree of agreement with the actual result.

Small scale endemism in Brazil's Atlantic Forest: 14 new species of Mesabolivar (Araneae, Pholcidae), each known from a single locality.

PubMed

Huber, Bernhard A

2015-04-07

In an ongoing mega-transect project that aims at analyzing pholcid spider diversity and distribution in the Atlantic Forest of Brazil, many species appear restricted to small geographic ranges. Of the 84 species collected between 2003 and 2011 at 17 sites between Bahia and Santa Catarina, 51 species (61%) were found at only one locality. The present paper focuses on such species in the genus Mesabolivar, and compares diversity and distribution patterns of this genus within and outside the Atlantic Forest. The percentage of species known from single localities is higher in the Atlantic Forest (34 of 52 species; 65%) than outside the Atlantic Forest (10 of 25; 40%). Distribution rages of species in the Atlantic Forest are significantly smaller than of species outside the Atlantic Forest (mean maximum distances between localities: 184 versus 541 km; medians: 10 km versus 220 km). The following species are newly described (arranged from north to south), each currently known from the respective type locality only: M. caipora; M. kathrinae; M. bonita; M. pau (Bahia); M. monteverde; M. perezi (Espírito Santo); M. giupponii; M. goitaca; M. sai (Rio de Janeiro); M. tamoio; M. unicornis; M. gabettae; M. inornatus (São Paulo); M. itapoa (Santa Catarina).

The mothers of prevention.

PubMed

1994-01-01

In New Caledonia, a 30-year-old teacher who is a mother of 12, Mme. Losa Otolose Terrat, composed a song in Wallisian about AIDS. A student nurse and several young Wallisian musicians called Sai recorded her song which was broadcast in April 1994. AIDS prevention messages have often neglected the Wallisian and Futunan community in New Caledonia. It is difficult for this community to discuss sex and sexuality, thereby causing resistance to AIDS prevention messages. Losa Otolose Terrat tried to use respectful words to reach all community members. Young people can talk about AIDS more frankly than their parents and older people, however. People who do not talk about AIDS often pick up copies of the Understanding AIDS booklet to read at home. The 1994 World AIDS Day theme is The Family and AIDS, an appropriate theme for the Wallisian and Futunan community, since the family is its focus. The church and other leaders should support AIDS prevention efforts to awaken the community's understanding of the need to prevent AIDS now to secure the future of the children. AIDS education is needed for older people. Younger people need to take action. Since mothers are the focal point of education, they are also needed to spread the message about AIDS.

VaST: A variability search toolkit

NASA Astrophysics Data System (ADS)

Sokolovsky, K. V.; Lebedev, A. A.

2018-01-01

Variability Search Toolkit (VaST) is a software package designed to find variable objects in a series of sky images. It can be run from a script or interactively using its graphical interface. VaST relies on source list matching as opposed to image subtraction. SExtractor is used to generate source lists and perform aperture or PSF-fitting photometry (with PSFEx). Variability indices that characterize scatter and smoothness of a lightcurve are computed for all objects. Candidate variables are identified as objects having high variability index values compared to other objects of similar brightness. The two distinguishing features of VaST are its ability to perform accurate aperture photometry of images obtained with non-linear detectors and handle complex image distortions. The software has been successfully applied to images obtained with telescopes ranging from 0.08 to 2.5 m in diameter equipped with a variety of detectors including CCD, CMOS, MIC and photographic plates. About 1800 variable stars have been discovered with VaST. It is used as a transient detection engine in the New Milky Way (NMW) nova patrol. The code is written in C and can be easily compiled on the majority of UNIX-like systems. VaST is free software available at http://scan.sai.msu.ru/vast/.

UV observations of local interstellar medium.

NASA Astrophysics Data System (ADS)

Kurt, V.; Mironova, E.; Fadeev, E.

2008-12-01

The methods of the interstellar matter study are described. The brief information of space missions aimed at observations in the unreachable for ground based telescopes UV spectral range (IUE, As- tron, HST and GALEX.) is presented. The history of discovery of H and He atoms entering the Solar System from the local interstellar medium (LISM) is given in brief. The results of observations performed by the group from Stern- berg Astronomical Institute (SAI MSU) and Space Research Institute (IKI RAS) performed with the help of the missions Prognoz-5, Prognoz-6 and the stations Zond-1, Venera and Mars and aimed at estimation of all basic LISM parameters (the velocity of the Sun in relation to LISM, directions of movement, densities of H and He atoms, LISM temperature) are presented. We also describe the present-day investigations of LISM performed with SOHO and ULYSSES mis- sions including the direct registration of He atoms entering the Solar System. The problem of interaction between the incoming flow of the ISM atoms ("in- terstellar wind") and the area of two shocks at the heliopause border (100-200 AU) is discussed. The LISM parameters obtained using the available data are presented in two tables.

Clinical and cognitive insight in patients with acute-phase psychosis: Association with treatment and neuropsychological functioning.

PubMed

Poyraz, Burç Çağri; Arikan, Mehmet Kemal; Poyraz, Cana Aksoy; Turan, Şenol; Kani, Ayşe Sakalli; Aydin, Eser; İnce, Ezgi

2016-10-01

The severity of psychopathology cannot fully explain deficits in the multi-dimensional construct of insight. The aim of this study was to evaluate the correlates and associations of clinical and cognitive insight in patients in an acute phase of psychosis and to analyse the impact of acute treatment on these variables. This study examined 47 inpatients who were recently hospitalized with acute exacerbation of schizophrenia. All subjects were assessed at both admission and discharge with the Positive and Negative Syndrome Scale (PANSS), Schedule for the Assessment of Insight-Expanded Version (SAI-E), Beck Cognitive Insight Scale (BCIS), and a neurocognition battery. Patients with schizophrenia gained clinical insight after treatment. Cognitive insight did not change significantly after treatment. Insight showed significant negative correlations with positive symptoms and general psychopathology, but not with negative symptoms. Clinical insight was not associated with neuropsychological functioning in this cohort. Gaining clinical insight in the acute phase of illness was associated with the remission of positive symptoms, but not with neuropsychological functioning. Some significant correlations between clinical and cognitive insights were detected, which suggests that cognitive insight contributes to clinical insight but is not treatment-dependent. Long-term treatment may be required to understand the contribution of insight to the outcome of patients with schizophrenia.

Effects of hypnosis during pregnancy: A psychophysiological study on maternal stress.

PubMed

Legrand, Fabien; Grévin-Laroche, Corinne; Josse, Elisabeth; Polidori, Guillaume; Quinart, Hervé; Taïar, Redha

2017-05-01

Because it induces a state of reduced awareness and deep relaxation, hypnosis is thought to be efficient at relieving stress and anxiety. This study examined whether hypnosis may alter the pattern and time evolution of maternal and fetal stress. Here we report a 23-yrs-old primigravida woman at 31-weeks' gestation who underwent daily sessions of hypnosis during one week. An A (baseline)-B (intervention) - A' (return to baseline) design was used. Each study phase lasted one week. The State Anxiety Inventory (SAI) was completed daily. Uterine contractions as well as maternal and fetal heart rate were recorded over 24-h periods in each of the study phase. Uterine contractions and maternal systolic blood pressure showed clear reductions during the hypnosis phase. In addition, a statistically significant declining trend in anxiety scores was observed during the hypnosis phase, and anxiety re-increased in the return-to-baseline phase (p<0.05). Coefficient of variation of maternal heart rate was found to be considerably lower during the hypnosis phase. Our results suggest that a short-lived hypnosis intervention (combined with standard care) holds sufficient promise for antenatal stress relief to justify testing its efficacy in larger groups of pregnant women. Copyright © 2017 Elsevier Ltd. All rights reserved.

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves

PubMed Central

Lima, Adley Antoninni Neves; Soares, Luiz Alberto Lira

2018-01-01

The species Kalanchoe brasiliensis, known as “Saião,” has anti-inflammatory, antimicrobial, and antihistamine activities. It also has the quercetin and kaempferol flavonoids, which exert their therapeutic activities. With extensive popular use besides the defined therapeutical properties, the study of possible side effects is indispensable. The objective of this study is to evaluate the toxicity in vitro and in vivo from the hydroethanolic extract of the leaves of K. brasiliensis. The action of the extract (concentrations from 0.1 to 1000 uL/100 uL) in normal and tumor cells was evaluated using the MTT method. Acute toxicity and subchronic toxicity were evaluated in mice with doses of 250 to 1000 mg/kg orally, following recognized protocols. The in vitro results indicated cytotoxic activity for 3T3 cell line (normal) and 786-0 (kidney carcinoma), showing the activity to be concentration-dependent, reaching 92.23% cell inhibition. In vivo, the extract showed no significant toxicity; only liver changes related to acute toxicity and some signs of liver damage, combining biochemical and histological data. In general, the extract showed low or no toxicity, introducing itself as safe for use with promising therapeutic potential. PMID:29593788

Open letter to Pope John Paul II.

PubMed

Sai, F

1991-01-01

In an Open Letter to Pope John Paul II, written on World Population Day (July 11) 1991, Dr. Fred Sai, President of International Planned Parenthood Federation (IPPF), called for a dialogue on voluntary family planning as a means of avoiding unwanted pregnancy. A half million women die each year from pregnancy-related causes--a death toll that could be dramatically reduced by universal access to low cost, effective contraception. Family planning further represents the best protection against abortion. The Catholic Church's vehement opposition to abortion and family planning methods other than periodic abstinence is in marked contrast to its support to human rights in other settings. The Church has supported struggles for economic ju stice in and among nations, sided with the poor, and advocated for transitions to democracy. At the same time, the family planning movement--which has as its overall objective the protection of the health and welfare of women, children, and families--is viewed by the Vatican as a vehicle for the enslavement rather than liberation of women. The opening of a sensitive dialogue between the Catholic Church and supporters of voluntary family planning could help couples make sound moral decisions about their families and contribute to saving the lives of millions of women, most of them poor.

Tropical wetlands - problems and potentials as paleo-monsoon archives

NASA Astrophysics Data System (ADS)

Chabangborn, Akkaneewut; Chawchai, Sakonvan; Fritz, Sherilyn; Löwemark, Ludvig; Wohlfarth, Barbara

2014-05-01

Paleoclimatic and paleoenvironmental information is still scarce for Southeast Asia despite the fact that this large region is home to numerous natural lakes and wetlands that may contain long sedimentary archives. During the past years we have been surveying lakes and wetlands in different parts of Thailand to select the most promising and longest sedimentary sequences for paleoenvironmental studies. Our survey of more than 30 lakes shows that only very few lakes and wetlands still contain soft sediments. The sediments in the majority of the lakes and wetlands have been dredged and excavated during the past 10 years to provide open and clear water for fishing and recreation. Dredging and excavation using large caterpillars has disturbed and in some cases completely destroyed the sedimentary records. Stiff clays now drape most of the lake bottoms. Based on our extensive survey, we found five sites, from which we successfully obtained intact sediment sequences: Lakes Kumphawapi and Pa Kho in northeast Thailand, Nong Leng Sai in northern Thailand and Sam Roi Yod and Nong Thale Pron in southern Thailand. All of these sites contain a detailed sedimentary record covering the past 2000 years, two of the sites cover parts of or, the entire Holocene; and two sites have sediments covering the last Termination and MIS 3, respectively.

The impact of telemedicine in the postoperative care of the neurosurgery patient in an outpatient clinic: a unique perspective of this valuable resource in the developing world--an experience of more than 3000 teleconsultations.

PubMed

Dadlani, Ravi; Mani, Subramaniyan; A U, Jai Ganesh; Mohan, Dilip; Rajgopalan, Niranjana; Thakar, Sumit; Aryan, Saritha; Hegde, Alangar S

2014-01-01

Telemedicine has always been used as a teleconsultation tool in neurological emergencies (e.g., triage in head injuries, stroke, and cerebrovascular accidents). At Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India, we have been operating two teleconsultation sessions per week for the postoperative patient population, addressing routine follow-up and semiemergent conditions in this cohort of patients. At our center more than 80% of the neurosurgical procedures are conducted in patients traveling more than 1500 km. Telemedicine as a routine tool in clinical medicine has significant financial and psychosocial benefits versus routine outpatient clinics. There are very few reports of telemedicine use in routine outpatient teleconsultations in the available neurosurgical literature; those that are present do not differentiate or analyze the use in routine versus emergency neurosurgery. We discuss the role of this underused resource in the developing countries and retrospectively analyze the clinical data in more than 1500 patients and 3000 teleconsultations during a period of 6 years. We address the financial implications, psychosocial factors, and several other factors that could make this relatively modest technology an indispensible tool in current neurosurgical practice, especially in a developing country like India. Copyright © 2014 Elsevier Inc. All rights reserved.

Digital Dilemma: Intellectual Property [and] The ERCIM Technical Reference Digital Library [and] International Information Gateway Collaboration [and] The Standards Fora for Online Education.

ERIC Educational Resources Information Center

Gladney, Henry M.; Andreoni, Antonella; Baldacci, Maria Bruna; Biagioni, Stefania; Carlesi, Carlo; Castelli, Donatella; Pagano, Pasquale; Peters, Carol; Pisani, Serena; Dempsey, Lorcan; Gardner, Tracy; Day, Michael; van der Werf, Titia; Bacsich, Paul; Heath, Andy; Lefrere, Paul; Miller, Paul; Riley, Kevin

1999-01-01

Includes four articles that discuss the impact of the emerging digital information infrastructure on intellectual property; the implementation of a digital library for a European consortium of national research institutions; an international information gateway collaboration; and developing standards for the description and sharing of educational…

Characterizing Awareness of Schizophrenia Among Facebook Users by Leveraging Facebook Advertisement Estimates.

PubMed

Saha, Koustuv; Weber, Ingmar; Birnbaum, Michael L; De Choudhury, Munmun

2017-05-08

Schizophrenia is a rare but devastating condition, affecting about 1% of the world's population and resulting in about 2% of the US health care expenditure. Major impediments to appropriate and timely care include misconceptions, high levels of stigma, and lack of public awareness. Facebook offers novel opportunities to understand public awareness and information access related to schizophrenia, and thus can complement survey-based approaches to assessing awareness that are limited in scale, robustness, and temporal and demographic granularity. The aims of this study were to (1) construct an index that measured the awareness of different demographic groups around schizophrenia-related information on Facebook; (2) study how this index differed across demographic groups and how it correlated with complementary Web-based (Google Trends) and non-Web-based variables about population well-being (mental health indicators and infrastructure), and (3) examine the relationship of Facebook derived schizophrenia index with other types of online activity as well as offline health and mental health outcomes and indicators. Data from Facebook's advertising platform was programmatically collected to compute the proportion of users in a target demographic group with an interest related to schizophrenia. On consultation with a clinical expert, several topics were combined to obtain a single index measuring schizophrenia awareness. This index was then analyzed for differences across US states, gender, age, ethnic affinity, and education level. A statistical approach was developed to model a group's awareness index based on the group's characteristics. Overall, 1.03% of Facebook users in the United States have a schizophrenia-related interest. The schizophrenia awareness index (SAI) is higher for females than for males (1.06 vs 0.97, P<.001), and it is highest for the people who are aged 25-44 years (1.35 vs 1.03 for all ages, P<.001). The awareness index drops for higher education

Characterizing Awareness of Schizophrenia Among Facebook Users by Leveraging Facebook Advertisement Estimates

PubMed Central

Weber, Ingmar; Birnbaum, Michael L; De Choudhury, Munmun

2017-01-01

Background Schizophrenia is a rare but devastating condition, affecting about 1% of the world’s population and resulting in about 2% of the US health care expenditure. Major impediments to appropriate and timely care include misconceptions, high levels of stigma, and lack of public awareness. Facebook offers novel opportunities to understand public awareness and information access related to schizophrenia, and thus can complement survey-based approaches to assessing awareness that are limited in scale, robustness, and temporal and demographic granularity. Objective The aims of this study were to (1) construct an index that measured the awareness of different demographic groups around schizophrenia-related information on Facebook; (2) study how this index differed across demographic groups and how it correlated with complementary Web-based (Google Trends) and non–Web-based variables about population well-being (mental health indicators and infrastructure), and (3) examine the relationship of Facebook derived schizophrenia index with other types of online activity as well as offline health and mental health outcomes and indicators. Methods Data from Facebook’s advertising platform was programmatically collected to compute the proportion of users in a target demographic group with an interest related to schizophrenia. On consultation with a clinical expert, several topics were combined to obtain a single index measuring schizophrenia awareness. This index was then analyzed for differences across US states, gender, age, ethnic affinity, and education level. A statistical approach was developed to model a group’s awareness index based on the group’s characteristics. Results Overall, 1.03% of Facebook users in the United States have a schizophrenia-related interest. The schizophrenia awareness index (SAI) is higher for females than for males (1.06 vs 0.97, P<.001), and it is highest for the people who are aged 25-44 years (1.35 vs 1.03 for all ages, P<.001

Sexual Enhancement Products for Sale Online: Raising Awareness of the Psychoactive Effects of Yohimbine, Maca, Horny Goat Weed, and Ginkgo biloba

PubMed Central

Corazza, Ornella; Martinotti, Giovanni; Santacroce, Rita; Chillemi, Eleonora; Di Giannantonio, Massimo; Schifano, Fabrizio; Cellek, Selim

2014-01-01

Introduction. The use of unlicensed food and herbal supplements to enhance sexual functions is drastically increasing. This phenomenon, combined with the availability of these products over the Internet, represents a challenge from a clinical and a public health perspective. Methods. A comprehensive multilingual assessment of websites, drug fora, and other online resources was carried out between February and July 2013 with exploratory qualitative searches including 203 websites. Additional searches were conducted using the Global Public Health Intelligence Network (GPHIN). Once the active constitutes of the products were identified, a comprehensive literature search was carried out using PsycInfo and PubMed. Results. The most common sexual enhancement products available on the Internet were identified. Their active ingredients included yohimbine, maca, horny goat weed and Ginkgo biloba. These four substances were reported with the occurrence of adverse events and the induction of psychological symptoms, such as mood changes, anxiety, and hallucinations as well as addictive behaviours. Conclusions. Uncontrolled availability of sexual enhancement products that contain potentially harmful substances is a major public health concern. The possible impact on population health, particularly among subjects with psychiatric disorders, usually at risk for sexual dysfunction, may be significant. This new trend needs to be extensively studied and monitored. PMID:25025070

Olanzapine as the ideal "trip terminator"? Analysis of online reports relating to antipsychotics' use and misuse following occurrence of novel psychoactive substance-related psychotic symptoms.

PubMed

Valeriani, Giuseppe; Corazza, Ornella; Bersani, Francesco Saverio; Melcore, Claudia; Metastasio, Antonio; Bersani, Giuseppe; Schifano, Fabrizio

2015-07-01

The pharmacological self-management of novel psychoactive substance (NPS)-induced psychopathological consequences represents a fast growing phenomenon. This is facilitated by the frequent sharing of NPS intake experiences online and by the ease of access to a range of psychotropic medications from both the online and street market. Olanzapine is anecdotally reported by Web users to be the most frequent self-prescribed medication to cope with NPS-induced psychoses. Hence, we aimed here at better assessing olanzapine use/misuse for this purpose. Exploratory qualitative searches of 163 discussion fora/specialized websites have been carried out in four languages (English, German, Spanish, and Italian) in the time frame November 2012-2013. Most NPS-users allegedly self administer with olanzapine to manage related psychotic crises/"bad trips". This may be typically taken only for a few days, at a dosage range of 5-50 mg/day. Only a few research studies have formally assessed the effectiveness of olanzapine and indeed of other second-generation antipsychotics to treat NPS-induced psychosis. Olanzapine was suggested here from a range of pro drug websites as being the "ideal" molecule to terminate "bad trips". Health professionals should be informed about the risks related to olanzapine misuse. Copyright © 2015 John Wiley & Sons, Ltd.

Understanding the impact of global trade liberalization on health systems pursuing universal health coverage.

PubMed

Missoni, Eduardo

2013-01-01

In the context of reemerging universalistic approaches to health care, the objective of this article was to contribute to the discussion by highlighting the potential influence of global trade liberalization on the balance between health demand and the capacity of health systems pursuing universal health coverage (UHC) to supply adequate health care. Being identified as a defining feature of globalization affecting health, trade liberalization is analyzed as a complex and multidimensional influence on the implementation of UHC. The analysis adopts a systems-thinking approach and refers to the six building blocks of World Health Organization's current "framework for action," emphasizing their interconnectedness. While offering new opportunities to increase access to health information and care, in the absence of global governance mechanisms ensuring adequate health protection and promotion, global trade tends to have negative effects on health systems' capacity to ensure UHC, both by causing higher demand and by interfering with the interconnected functioning of health systems' building blocks. The prevention of such an impact and the effective implementation of UHC would highly benefit from a more consistent commitment and stronger leadership by the World Health Organization in protecting health in global policymaking fora in all sectors. Copyright © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Estimating potential stranded commitments for U.S. investor-owned electric utilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, L.; Hirst, E.

New technologies, low natural gas prices, and federal and state utility regions are restructuring the electricity industry. Yesterday`s vertically integrated utility with a retail monopoly franchise may be a very different organization in a few years. Conferences, regulatory-commission hearings, and other industry fora are dominated by debates over the extent and form of utility deintegration, wholesale competition, and retail wheeling. A key obstacle to restructuring the electricity industry is stranded commitments. Past investments, power-purchase contracts, and public-policy-driven programs that made sense in an era of cost-of-service regulation may not be cost-effective in a competitive power market. Regulators, utilities, and othermore » parties face tough decisions concerning the mitigation and allocation of these stranded commitments. The authors developed and applied a simple method to calculate the amount of stranded commitments facing US investor-owned electric utilities. The results obtained with this method depend strongly on a few key assumptions: (1) the fraction of utility sales that is at risk with respect to competition, (2) the market price of electric generation, and (3) the number of years during which the utility would lose money because of differences between its embedded cost of production and the market price.« less

Past Fame, Present Frames and Future Flagship? An Exploration of How Health is Positioned in Canadian Foreign Policy

PubMed Central

Labonté, Ronald; Runnels, Vivien; Gagnon, Michelle

2014-01-01

Canada has been regarded as a model global citizen with firm commitments to multilateralism. It has also played important roles in several international health treaties and conventions in recent years. There are now concerns that its interests in health as a foreign policy goal may be diminishing. This article reports on a thematic analysis of key Canadian foreign policy statements issued over the past decade, and interviews with key informants knowledgeable of, or experienced in the interstices of Canadian health and foreign policy. It finds that health is primarily and increasingly framed in relation to national security and economic interests. Little attention has been given to human rights obligations relevant to health as a foreign policy issue, and global health is not seen as a priority of the present government. Global health is nonetheless regarded as something with which Canadian foreign policy must engage, if only because of Canada’s membership in many United Nations and other multilateral fora. Development of a single global health strategy or framework is seen as important to improve intersectoral cooperation on health issues, and foreign policy coherence. There remains a cautious optimism that health could become the base from which Canada reasserts its internationalist status. PMID:24977037

Evaluating the scattered radiation intensity in CBCT

NASA Astrophysics Data System (ADS)

Gonçalves, O. D.; Boldt, S.; Nadaes, M.; Devito, K. L.

2018-03-01

In this work we calculate the ratio between scattered and transmitted photons (STRR) by a water cylinder reaching a detector matrix element (DME) in a flat array of detectors, similar to the used in cone beam tomography (CBCT), as a function of the field of view (FOV) and the irradiated volume of the scanned object. We perform the calculation by obtaining an equation to determine the scattered and transmitted radiation and building a computer code in order to calculate the contribution of all voxels of the sample. We compare calculated results with the shades of gray in a central slice of a tomography obtained from a cylindrical glass container filled with distilled water. The tomography was performed with an I-CAT tomograph (Imaging Science International), from the Department of Dental Clinic - Oral Radiology, Universidade Federal de Juiz de Fora. The shade of gray (voxel gray value - VGV) was obtained using the software provided with the I-CAT. The experimental results show a general behavior compatible with theoretical previsions attesting the validity of the method used to calculate the scattering contributions from simple scattering theories in cone beam tomography. The results also attest to the impossibility of obtaining Hounsfield values from a CBCT.

Limited use of medicinal cannabis but for labeled indications after legalization.

PubMed

Erkens, J A; Janse, A F C; Herings, R M C

2005-11-01

Since September 2003, cannabis is available for medicinal purposes in Dutch pharmacies to. It was anticipated that the medicinal cannabis use via illegal ways would decrease. The objective of this study was to get insight in the use of medicinal cannabis in daily practise as dispensed by community pharmacies and to characterize the users as well as the symptoms and conditions cannabis is prescribed for.A prospective follow-up study among 200 patients who filled a prescription for medicinal cannabis was performed in the period between September 2003 and January 2004. The patients filled out a structured questionnaire concerning symptoms and conditions and their experience with cannabis. Of all patients, 42% suffered from multiple sclerosis, 11% suffered from rheumatic diseases, and 60% of respondents already used cannabis before the legalization. Cannabis was mainly used for chronic pain and muscle cramp/stiffness.The indication of medicinal cannabis use was in accordance with the labeled indications. However, more than 80% of the patients still obtained cannabis for medicinal purpose from the illegal circuit. Because of the higher prices in pharmacies, ongoing debate on the unproven effectiveness of the drug and the hesitation by physicians to prescribe cannabis. Copyright (c) 2005 John Wiley & Sons, Ltd.

The Hand of Cercopithecoides williamsi (Mammalia, Primates): Earliest Evidence for Thumb Reduction among Colobine Monkeys

PubMed Central

Frost, Stephen R.; Gilbert, Christopher C.; Pugh, Kelsey D.; Guthrie, Emily H.; Delson, Eric

2015-01-01

Thumb reduction is among the most important features distinguishing the African and Asian colobines from each other and from other Old World monkeys. In this study we demonstrate that the partial skeleton KNM-ER 4420 from Koobi Fora, Kenya, dated to 1.9 Ma and assigned to the Plio-Pleistocene colobine species Cercopithecoides williamsi, shows marked reduction of its first metacarpal relative to the medial metacarpals. Thus, KNM-ER 4420 is the first documented occurrence of cercopithecid pollical reduction in the fossil record. In the size of its first metacarpal relative to the medial metacarpals, C. williamsi is similar to extant African colobines, but different from cercopithecines, extant Asian colobines and the Late Miocene colobines Microcolobus and Mesopithecus. This feature clearly links the genus Cercopithecoides with the extant African colobine clade and makes it the first definitive African colobine in the fossil record. The postcranial adaptations to terrestriality in Cercopithecoides are most likely secondary, while ancestral colobinans (and colobines) were arboreal. Finally, the absence of any evidence for pollical reduction in Mesopithecus implies either independent thumb reduction in African and Asian colobines or multiple colobine dispersal events out of Africa. Based on the available evidence, we consider the first scenario more likely. PMID:25993410

Will the next generation of preferential trade and investment agreements undermine prevention of noncommunicable diseases? A prospective policy analysis of the Trans Pacific Partnership Agreement.

PubMed

Thow, Anne Marie; Snowdon, Wendy; Labonté, Ronald; Gleeson, Deborah; Stuckler, David; Hattersley, Libby; Schram, Ashley; Kay, Adrian; Friel, Sharon

2015-01-01

The Trans Pacific Partnership Agreement (TPPA) is one of a new generation of 'deep' preferential trade and investment agreements that will extend many of the provisions seen in previous agreements. This paper presents a prospective policy analysis of the likely text of the TPPA, with reference to nutrition policy space. Specifically, we analyse how the TPPA may constrain governments' policy space to implement the 'policy options for promoting a healthy diet' in the World Health Organization's Global Action Plan for Prevention and Control of Noncommunicable Diseases (NCDs) 2013-2020. This policy analysis suggests that if certain binding commitments are made under the TPPA, they could constrain the ability of governments to protect nutrition policy from the influence of vested interests, reduce the range of interventions available to actively discourage consumption of less healthy food (and to promote healthy food) and limit governments' capacity to implement these interventions, and reduce resources available for nutrition education initiatives. There is scope to protect policy space by including specific exclusions and/or exceptions during negotiation of trade and investment agreements like the TPPA, and by strengthening global health frameworks for nutrition to enable them to be used as reference during disputes in trade fora. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Developing a network: the PMM process.

PubMed

Kamara, A

1997-11-01

Since 1988, the Prevention of Maternal Mortality (PMM) Network has developed, implemented and evaluated projects that focus directly on prevention of maternal deaths. The Network, which consists of 11 multidisciplinary teams in West Africa and one at Columbia University, grew from discussions between the Carnegie Corporation of New York and researchers at Columbia School of Public Health. Its goals are: to strengthen capacities in developing countries; to provide program models for preventing maternal deaths; and to inform policymakers about the importance of maternal mortality. This paper describes the development and functioning of the Network. The initial steps included identifying interested partners in Africa and encouraging them to form multidisciplinary teams. Each African team received two grants: one to perform a needs assessment and then another to develop and implement projects based on the results. The Columbia team provided technical assistance in a variety of ways, including site visits, workshops and correspondence. Teams tested program models and reported findings both to local policymakers and in international fora. Collaboration with government and community leaders helped facilitate progress at all stages. At the PMM Network Results Conference in 1996, the teams decided to continue their work by forming the Regional PMM (RPMM) Network, an entirely African entity.

Synthesis and Application of Pyrrolidone-containing Shale Inhibitors

NASA Astrophysics Data System (ADS)

Liu, Yonggui; Hou, Jie; Zhang, Yang; Yan, Jing; Song, Tao; Xu, Yongjun

2018-03-01

New generation polyamine inhibitors are amino-terminated polyethers with excellent inhibiting capabilities; they play a key role in borehole stabilization and reservoir protection. However, polyamine inhibitors are limited by their poor thermal stability, which can be attributed to the presence of ether bonds in their molecular structures. We propose a three-step synthesis approach fora novel pyrrolidone-containing polyamine inhibitor (DYNP) by introducing N-vinyl-2-pyrrolidone (NVP) on divinyloxyethane. This polyamine inhibitor exhibits an optimized molecular structure and has enhanced heat resistance. Characterizations by infrared (IR) spectroscopy and evaluation tests demonstrate several advantages of DYNP inhibitors, including excellent inhibiting capability (superior to similar materials such as polyamines), improved heat resistance (reasonable stability at temperatures up to 240°C), and good compatibility with both fresh water and salt water drilling fluids. These can be attributed to the presence of considerable amounts of amino groups in the repeating unit of DYNP molecules. The DYNP inhibitor was applied in over 20 boreholes in tight oil blocks in Daqing Oilfield to relieve hydration of formations with high shale contents. For instance, drilling in the 2033.5m horizontal section of Dragon 2 borehole was smooth, with a borehole diameter expansion ratio below 10%.

Whakawhiti Kōrero, a Method for the Development of a Cultural Assessment Tool, Te Waka Kuaka, in Māori Traumatic Brain Injury.

PubMed

Elder, Hinemoa; Kersten, Paula

2015-01-01

The importance of tools for the measurement of outcomes and needs in traumatic brain injury is well recognised. The development of tools for these injuries in indigenous communities has been limited despite the well-documented disparity of brain injury. The wairua theory of traumatic brain injury (TBI) in Māori proposes that a culturally defined injury occurs in tandem with the physical injury. A cultural response is therefore indicated. This research investigates a Māori method used in the development of cultural needs assessment tool designed to further examine needs associated with the culturally determined injury and in preparation for formal validation. Whakawhiti kōrero is a method used to develop better statements in the development of the assessment tool. Four wānanga (traditional fora) were held including one with whānau (extended family) with experience of traumatic brain injury. The approach was well received. A final version, Te Waka Kuaka, is now ready for validation. Whakawhiti kōrero is an indigenous method used in the development of cultural needs assessment tool in Māori traumatic brain injury. This method is likely to have wider applicability, such as Mental Health and Addictions Services, to ensure robust process of outcome measure and needs assessment development.

Sexuality and 'silence' among Khasi youth of Meghalaya, Northeast India.

PubMed

War, Ryntihlin Jennifer; Albert, Sandra

2013-01-01

The importance of sex education has been well documented in the literature, but there exists a lack of research involving indigenous youth in India. This paper describes perceptions, knowledge and attitudes towards sex education, sexuality, pre-marital sex, rape and homosexuality among indigenous students from the matrilineal Khasi tribe attending a university in Meghalaya in northeast India. Qualitative and quantitative data were collected during and after reproductive health, sexuality and life skills courses. Despite the impression of sexual permissiveness of indigenous peoples that exists in India, students reported a societal silence on issues related to sexuality. Lack of appropriate words in the indigenous language potentially contributes to this silence. Although co-habitation is common and culturally acceptable, students disapproved of pre-marital sex. The influence of Christianisation was also perceived in the frequent reference to sin and guilt associated with masturbation, homosexuality, pre-marital sex and abortion. Students reported that the sex education received in school was 'childish' and inadequate for their adult needs. Many had unrealistic images of what constituted 'normal' sex and also blamed women for rape. The majority of indigenous students expressed the need for non-judgmental fora for discussions on sexual health and for sexuality education.

Past Fame, Present Frames and Future Flagship? An Exploration of How Health is Positioned in Canadian Foreign Policy.

PubMed

Labonté, Ronald; Runnels, Vivien; Gagnon, Michelle

2012-06-01

Canada has been regarded as a model global citizen with firm commitments to multilateralism. It has also played important roles in several international health treaties and conventions in recent years. There are now concerns that its interests in health as a foreign policy goal may be diminishing. This article reports on a thematic analysis of key Canadian foreign policy statements issued over the past decade, and interviews with key informants knowledgeable of, or experienced in the interstices of Canadian health and foreign policy. It finds that health is primarily and increasingly framed in relation to national security and economic interests. Little attention has been given to human rights obligations relevant to health as a foreign policy issue, and global health is not seen as a priority of the present government. Global health is nonetheless regarded as something with which Canadian foreign policy must engage, if only because of Canada's membership in many United Nations and other multilateral fora. Development of a single global health strategy or framework is seen as important to improve intersectoral cooperation on health issues, and foreign policy coherence. There remains a cautious optimism that health could become the base from which Canada reasserts its internationalist status.

[Buccal manifestations in patients submitted to chemotherapy].

PubMed

Hespanhol, Fernando Luiz; Tinoco, Eduardo Muniz Barretto; Teixeira, Henrique Guilherme de Castro; Falabella, Márcio Eduardo Vieira; Assis, Neuza Maria de Souza Picorelli

2010-06-01

Several changes in the oral cavity due to chemotherapy can be observed and can lead to important systemic complications, increasing the time of the patient in hospital and the costs of the treatment as well as affect the quality of life of the patients. The aim of this study was to assess the oral manifestation in patients treated with chemotherapy according to sex, age and tumor type. Data was collected in an oncology hospital in Juiz de Fora, Minas Gerais State, from patients' records that were submitted to oncologic treatment. It was possible to verify that mucositis, associated or not to other type of lesions, was the most common lesion in both sex of all ages (15.5%). Xerostomia and other lesions, such as Candida infection and aphthous lesions, were also present. It is possible to improve the quality of life of the patient during and after anti-neoplastic therapies through a protocol of odontological assistance that includes changes of the oral environment previous to chemotherapy such as profilaxis, caries removal, treatment of periodontal and periapical lesions, oral hygiene instructions, diet orientation and laser therapy. It is very important the insertion of the dentist in the oncologic medical team for the early diagnosis of the oral manifestation and follow-up during treatment time.

Symmetric peace education as advanced by Anatol Pikas — A critique and an analysis

NASA Astrophysics Data System (ADS)

Brock-Utne, Birgit

1983-09-01

The ideas of symmetric peace and symmetric peace education, developed by Anatol Pikas in the preceding article, are here criticised for their lack of definition; it is also alleged that inadequate explanation is given of how the concepts may be applied — for example, in the case of a strong power oppressing a weak one. In particular, this critique concentrates on Pikas' assumption of who the antagonists are, and on his belief in the value of prepared teaching materials. Brock-Utne argues that the common enemy is the arms race itself and that the inculcation of critical and discriminating attitudes is likely to be more effective than producing teaching packages. Constructive alternative ideas, incorporating some of Pikas' thinking, are offered. These emphasize (1) the importance of joint cultural/education exchange programmes for promoting international understanding at grass-roots level; (2) the need to put one's own house in order before criticising the neighbour's — a reference to Sweden's policies, with which Pikas claims to identify, and to the implications of Norway's membership of NATO for those in that country concerned with building peace; and (3) the desirability of setting up fora where, under the right conditions, a type of symmetric peace education can be pursued.

Governance Change and Institutional Adaptation: A Case Study from Harenna Forest, Ethiopia

NASA Astrophysics Data System (ADS)

Wakjira, Dereje T.; Fischer, Anke; Pinard, Michelle A.

2013-04-01

Many common pool resources have traditionally been managed through intricate local governance arrangements. Over time, such arrangements are confronted with manifold political, social, economic and ecological changes. However, the ways in which local governance arrangements react to such changes are poorly understood. Using the theoretical concept of institutional adaptation, we analyse the history of Harenna forest, Ethiopia, to examine processes of institutional change over the last 150 years. We find that the traditional institutions that governed Harenna's resources persisted, in essence, over time. However, these institutions were modified repeatedly to address changes caused by varying formal, supra-regional governance regimes, the development of markets for forest products, increasing population pressure and changes in formal property rights. A key mechanism for adaptation was combining elements from both informal and formal institutions, which allowed traditional rules to persist in the guise of more formal arrangements. Our findings also highlight several constraints of institutional adaptation. For example, by abolishing fora for collective decision-making, regime changes limited adaptive capacity. To conclude, we argue that such insights into traditional resource governance and its adaptability and dynamics over time are essential to develop sustainable approaches to participatory forest management for the future, both in Harenna and more generally.

Comparative analysis for strength serum sodium and potassium in three different methods: Flame photometry, ion-selective electrode (ISE) and colorimetric enzymatic.

PubMed

Garcia, Rafaela Alvim; Vanelli, Chislene Pereira; Pereira Junior, Olavo Dos Santos; Corrêa, José Otávio do Amaral

2018-06-19

Hydroelectrolytic disorders are common in clinical situations and may be harmful to the patient, especially those involving plasma sodium and potassium dosages. Among the possible methods for the dosages are flame photometry, ion-selective electrode (ISE) and colorimetric enzymatic method. We analyzed 175 samples in the three different methods cited from patients attending the laboratory of the University Hospital of the Federal University of Juiz de Fora. The values obtained were statistically treated using SPSS 19.0 software. The present study aims to evaluate the impact of the use of these different methods in the determination of plasma sodium and potassium. The averages obtained for sodium and potassium measurements by flame photometry were similar (P > .05) to the means obtained for the two electrolytes by ISE. The averages obtained by the colorimetric enzymatic method presented statistical difference in relation to ISE, both for sodium and potassium. In the correlation analysis, both flame photometry and colorimetric enzymatic showed a strong correlation with the ISE method for both dosages. At the first time in the same work sodium and potassium were analyzed by three different methods and the results allowed us to conclude that the methods showed a positive and strong correlation, and can be applied in the clinical routine. © 2018 Wiley Periodicals, Inc.

Hyperspectral Features of Oil-Polluted Sea Ice and the Response to the Contamination Area Fraction

PubMed Central

Li, Ying; Liu, Chengyu; Xie, Feng

2018-01-01

Researchers have studied oil spills in open waters using remote sensors, but few have focused on extracting reflectance features of oil pollution on sea ice. An experiment was conducted on natural sea ice in Bohai Bay, China, to obtain the spectral reflectance of oil-contaminated sea ice. The spectral absorption index (SAI), spectral peak height (SPH), and wavelet detail coefficient (DWT d5) were calculated using stepwise multiple linear regression. The reflectances of some false targets were measured and analysed. The simulated false targets were sediment, iron ore fines, coal dust, and the melt pool. The measured reflectances were resampled using five common sensors (GF-2, Landsat8-OLI, Sentinel3-OLCI, MODIS, and AVIRIS). Some significant spectral features could discriminate between oil-polluted and clean sea ice. The indices correlated well with the oil area fractions. All of the adjusted R2 values exceeded 0.9. The SPH model1, based on spectral features at 507–670 and 1627–1746 nm, displayed the best fitting. The resampled data indicated that these multi-spectral and hyper-spectral sensors could be used to detect crude oil on the sea ice if the effect of noise and spatial resolution are neglected. The spectral features and their identified changes may provide reference on sensor design and band selection. PMID:29342945

Analysis of Mid-Latitude Plasma Density Irregularities in the Presence of Finite Larmor Radius Effects

NASA Astrophysics Data System (ADS)

Sotnikov, V. I.; Kim, T. C.; Mishin, E. V.; Kil, H.; Kwak, Y. S.; Paraschiv, I.

2017-12-01

Ionospheric irregularities cause scintillations of electromagnetic signals that can severely affect navigation and transionospheric communication, in particular during space storms. At mid-latitudes the source of F-region Field Aligned Irregularities (FAI) is yet to be determined. They can be created in enhanced subauroral flow channels (SAI/SUBS), where strong gradients of electric field, density and plasma temperature are present. Another important source of FAI is connected with Medium-scale travelling ionospheric disturbances (MSTIDs). Related shear flows and plasma density troughs point to interchange and Kelvin-Helmholtz type instabilities as a possible source of plasma irregularities. A model of nonlinear development of these instabilities based on the two-fluid hydrodynamic description with inclusion of finite Larmor radius effects will be presented. This approach allows to resolve density irregularities on the meter scale. A numerical code in C language to solve the derived nonlinear equations for analysis of interchange and flow velocity shear instabilities in the ionosphere was developed. This code will be used to analyze competition between interchange and Kelvin-Helmholtz instabilities in the mid-latitude region. The high-resolution simulations with continuous density and velocity profiles will be driven by the ambient conditions corresponding to the in situ data obtained during the 2016 Daejeon (Korea) and MU (Japan) radar campaign and data collected simultaneously by the Swarm satellites passed over Korea and Japan. PA approved #: 88ABW-2017-3641

Reliability and Validity of the Korean Version of the Symptom Checklist-Post-Traumatic Stress Disorder Scale

PubMed Central

2016-01-01

The Symptom Checklist - Post-Traumatic Stress Disorder Scale (SCL-PTSD), also known as Crime-Related PTSD Scale has been validated in survivors of interpersonal trauma in the general population. However, the psychometric properties have not been investigated in a clinical setting for patients with PTSD from diverse traumatic events. This study investigates the reliability and validity of the Korean version of the SCL-PTSD among 104 psychiatric outpatients with PTSD, caused by interpersonal (n = 50) or non-interpersonal trauma (n = 54). Self-report data of the SCL-PTSD, Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Impact of Events Scale-Revised (IES-R) were gathered. The Korean version of the SCL-PTSD showed excellent internal consistency and moderate-to-good four-week temporal stability in both the interpersonal and non-interpersonal trauma groups. In comparison with other diagnostic groups, the scores of the SCL-PTSD were significantly higher compared to those of adjustment disorder, depression, other anxiety disorders, and schizophrenia, demonstrating its criteria-related validity. Convergent validity was confirmed because the scores of the SCL-PTSD were significantly correlated with BDI, SAI and TAI scores. Concurrent validity was demonstrated by significant correlation with the IES-R score. This study demonstrated the favorable psychometric prosperities of the Korean version of the SCL-PTSD, supporting its use in clinical research and practice. PMID:27134501

Pozzolanic Activity Assessment of LUSI (LUmpur SIdoarjo) Mud in Semi High Volume Pozzolanic Mortar

PubMed Central

Hardjito, Djwantoro; Antoni; Wibowo, Gunadi M.; Christianto, Danny

2012-01-01

LUSI mud obtained from the mud volcano in Sidoarjo, Indonesia, is a viable aluminosilicate material to be utilized as pozzolanic material. LUSI is an abbreviation of the local name of the mud, i.e., Lumpur Sidoarjo, meaning Sidoarjo mud. This paper reports the results of an investigation to assess the pozzolanic activity of LUSI mud, especially in semi high volume pozzolanic mortar. In this case, the amount of mud incorporated is between 30% to 40% of total cementitious material, by mass. The content of SiO2 in the mud is about 30%, whilst the total content of SiO2, Fe2O3 and Al2O3 is more than 70%. Particle size and degree of partial cement replacement by treated LUSI mud affect the compressive strength, the strength activity index (SAI), the rate of pozzolanic activity development, and the workability of mortar incorporating LUSI mud. Manufacturing semi high volume LUSI mud mortar, up to at least 40% cement replacement, is a possibility, especially with a smaller particle size of LUSI mud, less than 63 μm. The use of a larger percentage of cement replacement by LUSI mud does not show any adverse effect on the water demand, as the flow of the fresh mortar increased with the increase of percentage of LUSI mud usage.

EOS ART: Six Artistic Projects Inspired by Earth Science

NASA Astrophysics Data System (ADS)

Kerlow, Isaac

2015-04-01

The six projects produced under the artists' residencies at the Earth Observatory of Singapore (EOS) were inspired by Earth science and by the human experience in naturally hazardous regions. These contemporary artworks were created within an interdisciplinary framework that fostered collaborations between artists and scientists. EOS ART was a pilot program that also facilitated the active engagement of regional artists with issues related to Earth science, sustainable societies, and innovative methods for science outreach. An interdisciplinary jury of art critics, curators and Earth scientists selected art projects proposed by regional artists, and funds were awarded to develop and realize the projects. The artworks-including installations, photographs, and video art-were showcased in the "Unearthed" public exhibit at the Singapore Art Museum from March to July of 2014. A 92-page catalog accompanied the show and public seminars about interdisciplinary connections complemented the event. This was a unique example of collaboration between scientific and artistic institutions in Southeast Asia. The paper provides an overview of the motivations, process and accomplished results. The art projects include "Coastline" by Zhang Xiao (China), "Lupang" by Clara Balaguer and Carlos Casas (Philippines and Spain), "Sound of the Earth" by Chen Sai Hua Kuan (Singapore), "Sudden Nature" by Isaac Kerlow (Mexico/USA), "The Possibility of Knowing" by Robert Zhao Renhui (Singapore), and "When Need Moves the Earth" by Sutthirat Supaparinya (Thailand).

A Cross-Sectional Survey of Intestinal Helminthiases in Rural Communities of Nakhon Ratchasima Province, Thailand.

PubMed

Kaewpitoon, Soraya J; Loyd, Ryan A; Kaewpitoon, Natthawut

2015-05-01

The public-health problems caused by intestinal helminthic infections have been neglected in rural areas where there remains a lack of hygiene and an inadequate supply ofsanitary water This research was to study the infection rate of intestinal helminthiases and socioeconomic data within two communities in Nakhon Ratchasima province. Intestinal helminthiases were examined using Kato's Thick Smear technique and socio-demographic data was collected using predesigned semi-structured questionnaires. 209 stool samples were collected from 83 male and 126 female participants. Stool examinations showed that 6.22% (13/209) of study participants were infected with intestinal helminths, predominantly hookworm (4.31%, 9/209) followed by Strongyloides stercolaris (1.44%, 2/209), and Taenia sp. (0.48%, 1/209). Males were slightly more likely to be infected than females. Intestinal helminthic infection was more commonlyfound in the 61-70 year age group andpositively associated with occupation ofagriculture. The Tanod sub-district had an intestinal helminthiases rate of 10.59%, higher than in the Wang Sai sub-district. In conclusion, this study shows that intestinal helminthic infections are common parasitic infections among patients presenting for a small scale survey of a rural Thai community. This information may provide invaluable statistics needed for planning meaningful public control programs that aim at reducing the prevalence and morbidity of parasitic infections. Large scale surveys and health education are urgently required.

Caffeinated energy drink intake modulates motor circuits at rest, before and after a movement.

PubMed

Concerto, Carmen; Infortuna, Carmenrita; Chusid, Eileen; Coira, Diego; Babayev, Jacqueline; Metwaly, Rowan; Naenifard, Hesam; Aguglia, Eugenio; Battaglia, Fortunato

2017-10-01

Energy drinks are thought to improve certain aspects of athletic and cognitive performances. Moreover, less is understood about physiological mechanisms that might underlie these effects. The aim of this study was to examine the influence of sugar-free energy drink (SFED) ingestion on corticomotor excitability and plasticity. Fourteen college students consumed a commercially available SFED or a "dummy" drink. By using Transcranial magnetic Stimulation (TMS) we investigated resting motor threshold (RMT), motor evoked potential (MEP) amplitude and cortical silent period (CSP). Paired-pulse stimulation was used to assess short interval intracortical inhibition (SICI) and intracortical facilitation (ICF). Sensorimotor integration was investigated with the short- and long-afferent inhibition paradigms (SAI and LAI). Cortical plasticity was studied with the paired associative stimulation (PAS) paradigm. In addition, we examined the effect of SFED on simple reaction time (RT), pre-movement facilitation and post-exercise facilitation (PEF). SFED consumption decreased ICF, shortened RT, increased pre-movement facilitation and PEF of the motor evoked potentials. These results demonstrate that SFED consumption induced a shorter RT that is paralleled by changes in cortical excitability at rest, prior and after a non-fatiguing muscle contraction. These acute changes in brain function might be of relevance in understanding the mechanisms underlying the enhancement of psychomotor performance. Copyright © 2017 Elsevier Inc. All rights reserved.

Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe

PubMed Central

Fernandes, Por Luís

2011-01-01

Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

Impacts on regional climate of an afforestation scenario under a +2°C global warming climate

NASA Astrophysics Data System (ADS)

Strada, Susanna; Noblet-Ducoudré Nathalie, de; Marc, Stéfanon

2017-04-01

Through surface-atmosphere interactions (SAI), land-use and land-cover changes (LULCCs) alter atmospheric conditions with effects on climate at different scales, from local/regional (a few ten kilometres) (Pielke et al., 2011) to global scales (a few hundred kilometres) (Mahmood et al., 2014). Focusing on the regional scale, in the context of climate change, LULCCs may either enhance or dampen climate impacts via changes in SAI they may initiate. Those LULCC-driven atmospheric impacts could in turn influence e.g. the functioning of terrestrial ecosystems, with consequences on mitigation and adaptation strategies. Despite LULCC impacts on regional climate are largely discussed in the literature, in Europe information is missing on LULCC impacts under future climate conditions on a country scale (Galos et al., 2015). The latest COPs have urged the scientific community to explore the impacts of reduced global warming (1.5°C to a +2°C) on the Earth system. LULCCs will be one major tool to achieve such targets. In this framework, we investigate impacts on regional climate of a modified landscape under a +2°C climatic scenario. To this purpose, we performed sensitivity studies over western Europe with a fully coupled land-atmosphere regional climate model, WRF-ORCHIDEE (Drobinski et al., 2012, Stefanon et al., 2014). A +2°C scenario was selected among those proposed by the "Impact2C" project (Vautard et al., 2014), and the afforested land-cover scenario proposed in the RCP4.5 is prescribed. We have chosen the maximum extent of forest RCP4.5 simulates for Europe at the end of the 21st century. WRF-ORCHIDEE is fed with boundary atmospheric conditions from the global climate model LMDZ for PD (1971-2000) and the +2°C warming period for the LMDZ model (2028-2057). Preliminary results over the target domain show that, under a +2°C global warming scenario, afforestation contributes by 2% to the total warming due to both climate change and LULCCs. During summer, the

Decentralization can help reduce deforestation when user groups engage with local government.

PubMed

Wright, Glenn D; Andersson, Krister P; Gibson, Clark C; Evans, Tom P

2016-12-27

Policy makers around the world tout decentralization as an effective tool in the governance of natural resources. Despite the popularity of these reforms, there is limited scientific evidence on the environmental effects of decentralization, especially in tropical biomes. This study presents evidence on the institutional conditions under which decentralization is likely to be successful in sustaining forests. We draw on common-pool resource theory to argue that the environmental impact of decentralization hinges on the ability of reforms to engage local forest users in the governance of forests. Using matching techniques, we analyze longitudinal field observations on both social and biophysical characteristics in a large number of local government territories in Bolivia (a country with a decentralized forestry policy) and Peru (a country with a much more centralized forestry policy). We find that territories with a decentralized forest governance structure have more stable forest cover, but only when local forest user groups actively engage with the local government officials. We provide evidence in support of a possible causal process behind these results: When user groups engage with the decentralized units, it creates a more enabling environment for effective local governance of forests, including more local government-led forest governance activities, fora for the resolution of forest-related conflicts, intermunicipal cooperation in the forestry sector, and stronger technical capabilities of the local government staff.

Climate Information and Misinformation: Getting the Message Out

NASA Astrophysics Data System (ADS)

Carr, M.; Rubenstein, M.; Brash, K.; Hernandez, T. E.; Anderson, R. F.; Fulton, M.; Kahn, B.

2010-12-01

While it is commonly accepted that improved science comprehension is a key element to informed decisions on the many societal issues that interface with science and technology, it is not always clear what that understanding should entail. Is it knowledge of a set of facts and their context, the ability to read scientific papers, familiarity with data sets and their strengths and limitations, the development of original research? Physical scientists continue to operate assuming the deficit model: that lack of societal engagement results from ignorance or lack of information. Yet, in the case of climate, an active community of citizen scientists is engaged in a parallel research activity that aims to audit the basic tenets of the field, thus illustrating that greater literacy does not necessarily lead to consensus. Communication experts have long noted the inadequacy of the deficit model, highlighting the importance of prior knowledge, interests, and values. Science communicators recommend direct public engagement using non-traditional tools and fora. Here we explore three modes of engaging the public on the theme of climate change skepticism: a report published by a major financial institution (following a deficit model, but targeting a highly educated non-science community), blogging (using the broad potential reach and ongoing engagement of the internet), and student discussion groups (taking a participatory 'community outreach' approach).

Competitive Memory Training (COMET) for OCD: a self-treatment approach to obsessions.

PubMed

Schneider, Brooke C; Wittekind, Charlotte E; Talhof, Alina; Korrelboom, Kees; Moritz, Steffen

2015-01-01

Competitive Memory Training (COMET) is a cognitive intervention that aims to change the maladaptive cognitive-emotional networks underlying obsessive-compulsive disorder (OCD). COMET has not been previously tried as a self-help intervention. The present study tested the preliminary feasibility, acceptability, and effectiveness of COMET for OCD implemented as a self-help intervention. Sixty-five participants with OCD recruited through online OCD self-help fora completed an online baseline assessment including measures of OCD symptoms, self-esteem, and depression. Participants were randomly assigned to either COMET or a wait-list control group. All participants were approached 4 weeks later to complete an online post-assessment. There was no evidence for a greater decline of OCD symptoms or depression under COMET. When analyses were limited to only those participants who reported reading the entire manual at least once, self-esteem was higher at post-assessment in the COMET group. Although 78.1% of patients in the COMET group rated it as appropriate for self-administration, only 56.5% performed COMET exercises regularly and 26.4% read the entire manual at least once. The feasibility and effectiveness of COMET as a self-help internet intervention for OCD was not supported in this study. Further work is needed to better understand if modifications to our implementation of COMET may yield improved outcomes.

Earth Observations taken by the Expedition 21 Crew

NASA Image and Video Library

2009-10-22

ISS021-E-011833 (22 Oct. 2009) --- The southern Savage Islands in the Atlantic Ocean are featured in this image photographed by an Expedition 21 crew member on the International Space Station. The Savage Islands, or Ilhas Selvagens in Portuguese, comprise a small archipelago in the eastern North Atlantic Ocean between the archipelago of Madeira to the north and the Canary Islands to the south. Like other island groups, the Savage Islands are thought to have been produced by volcanism related to a mantle plume or ?hot spot?. Mantle plumes are relatively fixed regions of upwelling magma that can feed volcanoes on an overlying tectonic plate. Active volcanoes form over the plume, and become dormant as they are carried away on the moving tectonic plate. Scientists believe that over geologic time, this creates a line of older extinct volcanoes, seamounts, and islands extending from the leading active volcanoes that are currently over the plume. This view illustrates the smaller and more irregularly-shaped Ilheus do Norte, Ilheu de Fora, and Selvagem Pequena. Spain and Portugal both claim sovereignty over the Savage Islands. All of the islands of the archipelago are ringed by bright white breaking waves along the fringing beaches. Coral reefs that surround the Savage Islands make it very difficult to land boats there, and there is no permanent settlement on the islands.

Patterns of use and toxicity of new para-halogenated substituted cathinones: 4-CMC (clephedrone), 4-CEC (4-chloroethcatinone) and 4-BMC (brephedrone).

PubMed

Grifell, Marc; Ventura, Mireia; Carbón, Xoán; Quintana, Pol; Galindo, Liliana; Palma, Álvaro; Fornis, Ivan; Gil, Cristina; Farre, Magi; Torrens, Marta

2017-05-01

This paper aims to present results of the analysis of clephedrone (4-CMC), 4-chloroethcathinone (4-CEC), and brephedrone (4-BMC) on recreational drug markets and a systematic review of all the available information concerning these substances. Samples collected by the drug checking service of the Spanish harm reduction NGO-Energy Control were analyzed and systematic research was conducted. Between June 2014 and October 2016, 1,471 samples with at least one NPS were analyzed, 397 of which contained cathinones. Clephedrone was found in 29 samples, brephedrone in 8, and both were present in 2 samples. 4-Chloroethcathinone was detected in 5 samples. Eleven out of the 47 purchased samples (23.4%) were tested to contain the substance the user expected. Samples received were mainly sold as 3-MMC, MDMA, ketamine, and other cathinones. No literature on the effects or toxicity of these substances was found; the only information available was on internet fora. On many posts, users exhibit concerns about potential toxicity and side effects of using these substances. Since the emergence of these substances could prove to be the next step to the cat-and-mouse game existing between drug producers and legislation, further clinical and epidemiological research should be carried out in order to build evidence to support policy for public health issues. Copyright © 2017 John Wiley & Sons, Ltd.

Food environment, social deprivation and obesity among students from Brazilian public schools.

PubMed

Assis, Maíra Macário de; Leite, Maria Alvim; Carmo, Ariene Silva do; Andrade, Amanda Cristina de Souza; Pessoa, Milene Cristine; Netto, Michele Pereira; Cândido, Ana Paula Carlos; Mendes, Larissa Loures

2018-05-11

To investigate the relationship between social deprivation and the food environment. Furthermore, to evaluate if the food environment is associated with the prevalence of obesity among students in Brazilian public schools. Cross-sectional. For the classification of obesity, weight and height were measured, and the cut-off point of BMI-for-age Z-score >+2 was adopted. Social deprivation level was determined from the Health Vulnerability Index (HVI). To assess the food environment, the density of food establishments in urban residential areas was calculated. Associations between the food environment and the presence of obesity were estimated by binary logistic regression through a generalized estimating equations model. Juiz de Fora, Minas Gerais, Brazil. Children and adolescents (n 661) aged 7-14 years. The lowest social deprivation level showed a higher density of all types of establishments that sold predominantly unhealthy foods. An inverse association was found between the density of supermarkets and hypermarkets and the presence of obesity (OR=0·58; 95 % CI 0·36, 0·93). For the other categories of food retailers, no significant differences were found. The findings reinforce the need for public policies that promote equality in the food environments of the city. Also, further investigations into the influence of the presence of supermarkets on the nutritional status of children and adolescents are required.

Seeing through the public health smoke-screen in drug policy.

PubMed

Csete, Joanne; Wolfe, Daniel

2017-05-01

In deliberations on drug policy in United Nations fora, a consensus has emerged that drug use and drug dependence should be treated primarily as public health concerns rather than as crimes. But what some member states mean by "public health approach" merits scrutiny. Some governments that espouse treating people who use drugs as "patients, not criminals" still subject them to prison-like detention in the name of drug-dependence treatment or otherwise do not take measures to provide scientifically sound treatment and humane social support to those who need them. Even drug treatment courts, which the U.S. and other countries hold up as examples of a public health approach to drug dependence, can serve rather to tighten the hold of the criminal justice sector on concerns that should be addressed in the health sector. The political popularity of demonisation of drugs and visibly repressive approaches is an obvious challenge to leadership for truly health-oriented drug control. This commentary offers some thoughts for judging whether a public health approach is worthy of the name and cautions drug policy reformers not to rely on facile commitments to health approaches that are largely rhetorical or that mask policies and activities not in keeping with good public health practise. Copyright © 2017 Elsevier B.V. All rights reserved.

Bridge over troubled waters: A Synthesis Session to connect ...

EPA Pesticide Factsheets

Lack of access to relevant scientific data has limited decision makers from incorporating scientific information into their management and policy schemes. Yet, there is increasing interest among decision makers and scientists to integrate coastal and marine science into the policy and management process. Strategies designed to build communication between decision makers and scientists can be an effective means to disseminate and/or generate policy relevant scientific information. Here researchers develop, test, and present a workshop model designed to bridge the gap between coastal and marine decision makers and scientists. Researchers identify successful components of such a workshop as well as areas for improvement and recommendations to design and conduct similar workshops in the future. This novel workshop format can be used in other fora to effectively connect decision makers and scientists, and to initiate an iterative process to generate and transfer policy relevant scientific information into evidence-based decisions, an important element in protecting coastal and marine resources. In this paper we develop and present a model for increasing collaboration between scientists and decision makers to promote evidence based decisions. Successes and areas for improvement in the tested model are discussed. This novel workshop model is intended to build and sustain connections, with the ultimate goal of creating better policy and management practices. In a recent

Equity and financing for sexual and reproductive health service delivery: current innovations.

PubMed

Montagu, Dominic; Graff, Maura

2009-07-01

National and international decisions on financing for sexual and reproductive health (SRH) services have profound effects on the type, unit costs and distribution of SRH commodities and services produced, and on their availability and consumption. Much international and national funding is politically driven and is doing little for equity and quality improvement. Financing remains a significant challenge in most developing countries and demands creative responses. While no "one-size-fits-all" solution exists, there are numerous ongoing examples of successful innovations, many of which are focusing on resource pooling and on purchasing or subsidising SRH services. In this article we have used interviews, grey literature and presentations made at a range of recent public fora to identify new and innovative ways of financing SRH services so as to increase equity in developing countries. Because SRH services are often of low value as a personal good but high value as a public good, we summarise the issues from a societal perspective, highlighting the importance of financing and policy decisions for SRH services. We provide a structured overview of what novel approaches to financing appear to have positive effects in a range of developing countries. Targeting, government payment mechanisms, subsidy delivery and co-financing for sustainability are highlighted as showing particular promise. Examples are used throughout the article to illustrate innovative strategies.

Production of a germline-humanized cetuximab scFv and evaluation of its activity in recognizing EGFR- overexpressing cancer cells.

PubMed

Banisadr, Arsham; Safdari, Yaghoub; Kianmehr, Anvarsadat; Pourafshar, Mahdieh

2018-04-03

The aim of this study was to produce a humanized single chain antibody (scFv) as a potential improved product design to target EGFR (Epidermal Growth Factor Receptor) overexpressing cancer cells. To this end, CDR loops of cetuximab (an FDA-approved anti-EGFR antibody) were grafted on framework regions derived from type 3 (VH3 and VL3 kappa) human germline sequences to obtain recombinant VH and VL domainslinked together with a flexible linker [(Gly 4 Ser) 3 ] to form a scFv. Codon optimized synthetic gene encoding the scFv (with NH2-VH-linker-VL-COOH orientation) was expressed in E. coli Origami™ 2(DE3) cells and the resultant scFv purified by using Ni-NTA affinity chromatography. The scFv, called cet.Hum scFv, was evaluated in ELISA and immunoblot to determine whether it can recognize EGFR. The scFv was able to recognize EGFR over-expressing cancer cells (A-431) but failed to detect cancer cells with low levels of EGFR (MCF-7 cells). Although the affinity of the scFv forA-431 cells was 9 fold lower than that of cetuximab, it was strong enough to recognize these cells. Considering its ability to bind EGFR molecules, the scFv may exhibit a potential application for the detection of EGFR-overexpressing cancer cells.

Stock options, tax credits or employment contracts please! The value of deliberative public disagreement about human tissue donation.

PubMed

Walmsley, Heather L

2011-07-01

'Deliberative democracy' is increasingly popular globally, as a means of securing public engagement with emerging health technologies and democratizing their governance. Architects of deliberative 'mini-publics' have tended, however, to privilege consensus within deliberation and the generation of 'action commitments' within a 'decisional context', despite widespread critique. Less attention has been paid to the phenomenon of persistent disagreement within constructed deliberative fora. This paper addresses this lacuna, performing a narrative analysis of four days of deliberation within one small group of demographically diverse public participants at the BC Biobank Deliberation (Vancouver, Canada, 2007). It reveals the value of listening to persistent deliberative disagreements. First, this paper argues that disagreements enable identification of deliberation and evaluation of its quality. Second, they generate insight into the deliberative process and the discursive means through which consensus can be achieved. Third, persistent deliberative disagreements can be creative of innovative governance solutions. In the case of the BC Biobank Deliberation, disagreements about compensation for biobank donors generated a range of suggestions for mediating between donor rights, corporate interests and societal needs--from tissue sample rentals to donor tax credits--suggestions that are unique to the existing academic and policy literature. Finally, this paper argues that practitioners should present persistent disagreements to public and policy audiences as an 'output' of deliberative democracy events. Copyright © 2011 Elsevier Ltd. All rights reserved.

Decentralization can help reduce deforestation when user groups engage with local government

PubMed Central

Wright, Glenn D.; Gibson, Clark C.; Evans, Tom P.

2016-01-01

Policy makers around the world tout decentralization as an effective tool in the governance of natural resources. Despite the popularity of these reforms, there is limited scientific evidence on the environmental effects of decentralization, especially in tropical biomes. This study presents evidence on the institutional conditions under which decentralization is likely to be successful in sustaining forests. We draw on common-pool resource theory to argue that the environmental impact of decentralization hinges on the ability of reforms to engage local forest users in the governance of forests. Using matching techniques, we analyze longitudinal field observations on both social and biophysical characteristics in a large number of local government territories in Bolivia (a country with a decentralized forestry policy) and Peru (a country with a much more centralized forestry policy). We find that territories with a decentralized forest governance structure have more stable forest cover, but only when local forest user groups actively engage with the local government officials. We provide evidence in support of a possible causal process behind these results: When user groups engage with the decentralized units, it creates a more enabling environment for effective local governance of forests, including more local government-led forest governance activities, fora for the resolution of forest-related conflicts, intermunicipal cooperation in the forestry sector, and stronger technical capabilities of the local government staff. PMID:27956644

Drug addiction and alcoholism as predictors for tuberculosis treatment default in Brazil: a prospective cohort study.

PubMed

Silva, M R; Pereira, J C; Costa, R R; Dias, J A; Guimarães, M D C; Leite, I C G

2017-12-01

This study aimed to evaluate the risk factors for tuberculosis (TB) treatment default in a priority city for disease control in Brazil. A cohort of TB cases diagnosed from 2008 to 2009 was followed up from patients' entry into three outpatient sites, in Juiz de Fora, Minas Gerais (Brazil), until the recording of the outcomes. Drug addiction, alcoholism and treatment site appeared to be independently associated with default. Current users of crack as the hardest drug (odds ratio (OR) 12·25, 95% confidence interval (CI) 3·04-49·26) were more likely to default than other hard drug users (OR 5·67, 95% CI 1·34-24·03), former users (OR 4·12, 95% CI 1·11-15·20) and those not known to use drugs (reference group). Consumers at high risk of alcoholism (OR 2·94, 95% CI 1·08-7·99) and those treated in an outpatient hospital unit (OR 8·22, 95% CI 2·79-24·21%) also were more likely to default. Our results establish that substance abuse was independently associated with default. National TB programmes might be more likely to achieve their control targets if they include interventions aimed at improving adherence and cure rates, by diagnosing and treating substance abuse concurrently with standard TB therapy.

An insight into the deep web; why it matters for addiction psychiatry?

PubMed

Orsolini, Laura; Papanti, Duccio; Corkery, John; Schifano, Fabrizio

2017-05-01

Nowadays, the web is rapidly spreading, playing a significant role in the marketing or sale or distribution of "quasi" legal drugs, hence facilitating continuous changes in drug scenarios. The easily renewable and anarchic online drug-market is gradually transforming indeed the drug market itself, from a "street" to a "virtual" one, with customers being able to shop with a relative anonymity in a 24-hr marketplace. The hidden "deep web" is facilitating this phenomenon. The paper aims at providing an overview to mental health's and addiction's professionals on current knowledge about prodrug activities on the deep web. A nonparticipant netnographic qualitative study of a list of prodrug websites (blogs, fora, and drug marketplaces) located into the surface web was here carried out. A systematic Internet search was conducted on Duckduckgo® and Google® whilst including the following keywords: "drugs" or "legal highs" or "Novel Psychoactive Substances" or "NPS" combined with the word deep web. Four themes (e.g., "How to access into the deepweb"; "Darknet and the online drug trading sites"; "Grams-search engine for the deep web"; and "Cryptocurrencies") and 14 categories were here generated and properly discussed. This paper represents a complete or systematical guideline about the deep web, specifically focusing on practical information on online drug marketplaces, useful for addiction's professionals. Copyright © 2017 John Wiley & Sons, Ltd.

Science and Systems in Support of Multi-hazard Early Warnings and Decisions

NASA Astrophysics Data System (ADS)

Pulwarty, R. S.

2015-12-01

The demand for improved climate knowledge and information is well documented. As noted in the IPCC (SREX, AR5), the UNISDR Global Assessment Reports and other assessments, this demand has increased pressure for information to support planning under changing rates and emergence of multiple hazards including climate extremes (drought, heat waves, floods). "Decision support" is now a popular term in the climate applications research community. While existing decision support activities can be identified in many disparate settings (e.g. federal, academic, private), the challenge of changing environments (coupled physical and social) is actually one of crafting implementation strategies for improving decision quality (not just meeting "user needs"). This includes overcoming weaknesses in co-production models, moving beyond DSSs as simply "software", coordinating innovation mapping and diffusion, and providing fora and gaming tools to identify common interests and differences in the way risks are perceived and managed among the affected groups. We outline the development and evolution of multi-hazard early warning systems in the United States and elsewhere, focusing on climate-related hazards. In particular, the presentation will focus on the climate science and information needed for (1) improved monitoring and modeling, (2) generating risk profiles, (3) developing information systems and scenarios for critical thresholds, (4) the net benefits of using new information (5) characterizing and bridging the "last mile" in the context of longer-term risk management.

Process and Equipment for Nitrogen Oxide Waste Conversion to Fertilizer

NASA Technical Reports Server (NTRS)

Lueck, Dale E. (Inventor); Parrish, Clyde F. (Inventor)

2000-01-01

The present invention describes a process for converting vapor streams from sources containing at least one nitrogen-containing oxidizing agent therein to a liquid fertilizer composition comprising the steps of: (1) directing a vapor stream containing at least nitrogen-containing oxidizing agent to a first contact zone; (2) contacting said vapor stream with water to form nitrogen oxide(s) from said at least one nitrogen- containing oxidizing agent; (3) directing said acid(s) as a second stream to a second contact zone; (4) exposing said second stream to hydrogen peroxide which is present within said second contact zone in a relative amount of at least 0.1% by weight of said second stream within said second contact zone to convert at least some of any nitrogen oxide species or ions other than in the nitrite form present within said second stream to nitrate ion; (5) sampling said stream within said second contact zone to determine the relative amount of hydrogen peroxide within said second contact zone; (6) adding hydrogen peroxide to said second contact zone when a level on hydrogen peroxide less than 0.1% by weight in said second stream is determined by said sampling; (7) adding a solution comprising potassium hydroxide to said second stream to maintain a pH between 6.0 and 11.0 within said second stream within said second contact zone to form a solution of potassium nitrate; and (8) removing sais solution of potassium nitrate from said second contact zone.

Usefulness of Patients-Reported Outcomes in Rheumatoid Arthritis Focus Group

PubMed Central

Amaya-Amaya, Jenny; Botello-Corzo, Diana; Calixto, Omar-Javier; Calderón-Rojas, Rolando; Domínguez, Aura-Maria; Cruz-Tapias, Paola; Montoya-Ortiz, Gladis; Mantilla, Ruben-Dario; Anaya, Juan-Manuel; Rojas-Villarraga, Adriana

2012-01-01

Objective. Patient-reported outcomes (PROs) have become an essential part of the assessment of patients with rheumatoid arthritis (RA). We aimed to evaluate the agreement and correlation between PROs and the physician's measurements. Methods. This was a cross-sectional analytical study in which 135 patients with RA were clinically evaluated during two different sessions of focus group interviews. Rheumatologist recorded 28 swollen (SJCs) and tender joint counts (TJCs). The patients filled out the PROs instruments (MDHAQ, RADAI, RAPID3, 4, and 5 and self-report articular index (SAI) diagram for pain and joint swelling). DAS28 was calculated (C-reactive protein). An adjusted multiple lineal regression model was done (DAS28 as dependent variable). Results. Highly significant agreements were found between SJC and TJC registered by the physician and patient. There was moderate correlation between DAS28 with patient SJC (r = 0.52), patient TJC (r = 0.55), RADAI (r = 0.56), RAPID3 (r = 0.52), RAPID4 (r = 0.56), RAPID5 (r = 0.66), and VAS-Global (r = 0.51). Likewise, we found moderate to high correlations between CDAI and SDAI with all variable measurements done by the patients. The resulting predictive equation was DAS28(CRP) = 2.02 + 0.037 × RAPID4 + 0.042× patient SJC. Conclusion. PROs applied in focus groups interview are a useful tool for managing patients with RA regardless of gender, educational level, and duration of disease. PMID:23097701

Pimozide versus fluphenazine in ambulatory schizophrenics: A 12-month comparison study.

PubMed

Donlon, P T; Swaback, D O; Osborne, M L

1977-02-01

In this study, chronic schizophrenic outpatients who had been maintained on various neuroleptics for an average of about 4 years had their previous medications (approximately equivalent to 695 mg of chlorpromazine per day) changed abruptly to either pimozide or fluphenazine given in single daily oral doses on a double-blind basis for a period of 52 weeks. Average daily doses were pimozide 9.6 mg and fluphenazine 12.5 mg. Measurements of the therapeutic effects of the two drugs were made immediately prior to starting the study, at the end of the 2nd and 4th weeks, and thereafter every 4th week to the end of the study. Three psychometric scales were used for evaluation: Brief Psychiatric Rating Scale (BPRS); Evaluation of Social Functioning (ESFR); and Clinical Global Impressions (CGI). In addition, patients participated in a Social Adjustment Inventory (SAI) evaluation. Statistical analysis with the use of several statistical techniques for between- and within-drug group comparisons revealed that pimozide and fluphenazine were equally effective in maintaining control of symptomatology of chronic schizophrenics at a level commensurate with or better than that provided by their previous medication. Side effects were characteristic of marketed neuroleptics, similar in severity and occurrence between study-drug groups, mainly extrapyramidal symptoms, and readily controlled with antiparkinsonian medication. Pimozide, slightly more potent than fluphenazine, proved to be equally effective for the long-term management of chronic schizophrenic patients.

Participatory evaluation of disaster resilience performance with urban stakeholders: An implementation case study before and after the 2015 Nepal Ghorka earthquake

NASA Astrophysics Data System (ADS)

Khazai, B.; Anhorn, J.; Burton, C.

2016-12-01

Approaches that make resilience tangible and operational for decision makers have to deal effectively with the degree of impact and change required through different strategic actions in addressing agreed-upon resilience goals. A Resilience Performance Scorecard (RPS) has been designed to enable local stakeholders in identifying existing strengths and weaknesses through providing information on key performance targets along six dimensions of urban resilience both at the city and sub-city district level of geography. The purpose in the development of the Scorecard approach is to build a tool that can provide information on the overall resilience performance and capture the key functional and organizational areas for urban resilience with local government officials. The Resilience Performance Scorecard (RPS) was developed jointly by the Center for Disaster Management and Risk Reduction Technology (CEDIM) at Karlsruhe Institute of Technology, the South Asia Institute (SAI) at Heidelberg University, the and Global Earthquake Model (GEM) Foundation. It was initially implemented with the Lalitpur Sub-Metropolitan Municipality in Nepal one year before the 25 April 7.8 magnitude Gorkha earthquake event as a self-evaluation tool through a fully participatory process with local stakeholders. In a follow-up participatory assessment and implementation of the RPS one month after the earthquake, the results of the participatory resilience investigation demonstrate areas where action towards resilience should be prioritized and reflect the change in perception of resilience among the stakeholders in the face of a large damaging event.

Self-organizing map network-based precipitation regionalization for the Tibetan Plateau and regional precipitation variability

NASA Astrophysics Data System (ADS)

Wang, Nini; Yin, Jianchuan

2017-12-01

A precipitation-based regionalization for the Tibetan Plateau (TP) was investigated for regional precipitation trend analysis and frequency analysis using data from 1113 grid points covering the period 1900-2014. The results utilizing self-organizing map (SOM) network suggest that four clusters of precipitation coherent zones can be identified, including the southwestern edge, the southern edge, the southeastern region, and the north central region. Regionalization results of the SOM network satisfactorily represent the influences of the atmospheric circulation systems such as the East Asian summer monsoon, the south Asian summer monsoon, and the mid-latitude westerlies. Regionalization results also well display the direct impacts of physical geographical features of the TP such as orography, topography, and land-sea distribution. Regional-scale annual precipitation trend as well as regional differences of annual and seasonal total precipitation were investigated by precipitation index such as precipitation concentration index (PCI) and Standardized Anomaly Index (SAI). Results demonstrate significant negative long-term linear trends in southeastern TP and the north central part of the TP, indicating arid and semi-arid regions in the TP are getting drier. The empirical mode decomposition (EMD) method shows an evolution of the main cycle with 4 and 12 months for all the representative grids of four sub-regions. The cross-wavelet analysis suggests that predominant and effective period of Indian Ocean Dipole (IOD) on monthly precipitation is around ˜12 months, except for the representative grid of the northwestern region.

Psychotic Symptoms and Attitudes toward Medication Mediate the Effect of Insight on Personal-Social Functions in Patients with Schizophrenia: One-Year Randomized Controlled Trial and Follow-Up.

PubMed

Zheng, Yingjun; Ning, Yuping; She, Shenglin; Deng, Yongjie; Chen, Yuwei; Yi, Wenying; Lu, Xiaodan; Chen, Xinrui; Li, Juanhua; Li, Ruikeng; Zhang, Jie; Xiao, Di; Wu, Haibo; Wu, Chao

2018-02-14

This study aimed to investigate the mediating pathway of 3 factors (psychotic symptoms, attitude toward medication, and cognitive processing speed) on the effect of insight on personal-social functioning in patients with schizophrenia. Chinese inpatients with schizophrenia (n = 168; mean age 18 ± 50 years) diagnosed according to the DSM-IV were randomly assigned to treatment with antipsychotic medication alone or combined treatment. Positive and Negative Syndrome Scale (PANSS), Drug Attitude Inventory (DAI), Assessment of Insight (SAI), and Social-Personal Performance Scale (PSPS) scores were evaluated at baseline and at 3, 6, and 12 months. Cognitive function was assessed at baseline. Multiple mediation analyses were conducted with baseline data, end point data, and changes-in-scale scores between baseline and the end point, respectively. At baseline and at 12 months, only psychotic symptoms mediated the effect of insight on personal-social functioning. For changes-in-scale scores over the 12-month follow-up, in patients receiving treatment with medication alone, the effect of improved insight on improved personal-social function was mediated by psychotic symptoms only; in patients receiving a combined treatment, the effect of improved insight on improved personal-social functioning was mediated by both psychotic symptoms and attitudes toward medication, independently. The link between insight and personal-social functions is mainly mediated by psychotic symptoms. Psychosocial intervention improves the predicting effect of insight on personal-social function by improving both the attitude toward medication and psychotic symptoms independently. © 2018 S. Karger AG, Basel.

A value-based, no-cost-to-patient health model in the developing world: Critical appraisal of a unique patient-centric neurosurgery unit

PubMed Central

Thakar, Sumit; Dadlani, Ravi; Sivaraju, Laxminadh; Aryan, Saritha; Mohan, Dilip; Sai Kiran, Narayanam Anantha; Rajarathnam, Ravikiran; Shyam, Maya; Sadanand, Venkatraman; Hegde, Alangar S.

2015-01-01

Background: It is well-accepted that the current healthcare scenario worldwide is due for a radical change, given that it is fraught with mounting costs and varying quality. Various modifications in health policies have been instituted toward this end. An alternative model, the low-cost, value-based health model, focuses on maximizing value for patients by moving away from a physician-centered, supply-driven system to a patient-centered system. Methods: The authors discuss the successful inception, functioning, sustainability, and replicability of a novel health model in neurosurgery built and sustained by inspired humanitarianism and that provides all treatment at no cost to the patients irrespective of their socioeconomic strata, color or creed. Results: The Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS) at Whitefield, Bengaluru, India, a private charitable hospital established in 2001, functions on the ideals of providing free state-of-the-art healthcare to all in a compassionate and holistic manner. With modern equipment and respectable outcome benchmarks, its neurosurgery unit has operated on around 18,000 patients since its inception, and as such, has contributed INR 5310 million (USD 88.5 million) to society from an economic standpoint. Conclusions: The inception and sustainability of the SSSIHMS model are based on self-perpetuating philanthropy, a cost-conscious culture and the dissemination of human values. Replicated worldwide, at least in the developing nations, this unique healthcare model may well change the face of healthcare economics. PMID:26322241

THE EOS ART Projects: Six Art Projects Inspired by Earth Science

NASA Astrophysics Data System (ADS)

Kerlow, I.

2015-12-01

The six projects produced under the artists' residencies at the Earth Observatory of Singapore (EOS) were inspired by Earth science and by the human experience in naturally hazardous regions. These contemporary artworks were created within an interdisciplinary framework that fostered collaborations between artists and scientists. The EOS ART 2010-2013 was a pilot program that also facilitated the active engagement of regional artists with issues related to Earth science, sustainable societies, and innovative methods for science outreach. An interdisciplinary jury of art critics, curators and Earth scientists selected art projects proposed by regional artists, and funds were awarded to develop and realize the projects.The artworks-including installations, photographs, and video art-were showcased in the "Unearthed" public exhibit at the Singapore Art Museum from March to July of 2014. A 92-page catalog accompanied the show and public seminars about interdisciplinary connections complemented the event. This was a unique example of collaboration between scientific and artistic institutions in Southeast Asia.The presentation provides an overview of the motivations, process and accomplished results. The art projects include "Coastline" by Zhang Xiao (China), "Lupang" by Clara Balaguer and Carlos Casas (Philippines and Spain), "Sound of the Earth" by Chen Sai Hua Kuan (Singapore), "Sudden Nature" by Isaac Kerlow (Mexico/USA), "The Possibility of Knowing" by Robert Zhao Renhui (Singapore), and "When Need Moves the Earth" by Sutthirat Supaparinya (Thailand). http://art-science-media.com/the-eos-art-projects/

Type II diabetes and personality; a study to explore other psychosomatic aspects of diabetes.

PubMed

Esmaeilinasab, Maryam; Ebrahimi, Mehdi; Mokarrar, Mohsen Heidari; Rahmati, Leila; Mahjouri, Mohammad Yoosef; Arzaghi, Seyed Masoud

2016-01-01

As one of the most common chronic diseases, diabetes and its control are affected by the patients' psychological and spiritual attributes. The present study investigates the relationship between glycemic control in patients with type II diabetes and personality traits, defense mechanisms and spirituality. The present cross-sectional study was conducted on 400 Iranian patients with type II diabetes, 64% were men. Participants completed the NEO Personality Inventory, the Defense Style Questionnaire (DSQ) and the Spiritual Assessment Inventory (SAI) and then underwent a blood sampling for the assessment of HbA1C levels. Of the five personality traits, extraversion ( r =  -0.13 and P <  0.01) and conscientiousness ( r =  -0.13 and P <  0.01) had significant negative relationships with HbA1C HbA1C levels, while neuroticism had a significant positive relationship with HbA1C levels ( r =  0.12 and P <  0.05). Of the defense styles assessed, the neurotic style was found to have a significant negative relationship with HbA1C levels ( r =  -0.1 and P <  0.05). Also, of the spirituality elements, impression management had significant relationship with glycemic control ( r =  0.17 and P <  0.001). According to data, Extraversion and conscientiousness can help control blood sugar while anxiety and negative emotions have detrimental effects on glycemic control. As a result considering psychological counselling beside medical interventions can help to better treatment.

Educational Pico-Satellite Project CUBESAT - University of Tokyo's CUBESAT XI and its Operation Plan

NASA Astrophysics Data System (ADS)

Tsuda, Y.; Sako, N.; Eishima, T.; Ito, T.; Arikawa, Y.; Miyamura, N.

2002-01-01

University of Tokyo ISSL (Intelligent Space Systems Laboratory) has been developing a pico-satellite called "CubeSat" as an international joint program. In CubeSat project, 10cm cubic satellites have been developed by several universities and launched to the low-earth orbit altogether by Russian rocket "Dnepr". ISSL has developed "XI" series ([sai]: X-factor Investigator) satellites, and the flight model is already fabricated and ready for delivery. The mission of XI satellite is the on-orbit technology demonstration of the ultra-small satellite bus system with an extensive use of commercial-off-the-shelf components. XI transmits the Morse beacon and FM packet telemetry which provides the health data of the satellite. Additionally, XI has a CMOS camera which provides 15,000 pixels panchromatic images as an advanced mission. Ground operation is one of the key issues for CubeSats. Now we are promoting international ground station network in which several universities' ground stations connected by internet collaboratively operate university-built small satellites, which enlarges the link opportunity. Collaboration with amateur HAM engineers is also indispensable for search for the satellite or get beacon signal to estimate the satellite orbit. We are now developing operation concept based on these ideas. As the launch is scheduled in this fall, the operation plan will be fixed at the time of this conference. In this presentation the final design of ISSL's CubeSat XI and operation plan will be presented.

Two sensory channels mediate perception of fingertip force.

PubMed

Brothers, Trevor; Hollins, Mark

2014-01-01

In two experiments we examined the ability of humans to exert forces accurately with the fingertips, and to perceive those forces. In experiment 1 participants used visual feedback to apply a range of fingertip forces with the distal pad of the thumb. Participants made magnitude discriminations regarding these forces, and their just noticeable differences were calculated at a series of standards by means of a two-interval, forced-choice tracking paradigm. As the standard increased, participants demonstrated a relative improvement in force discrimination; and the presence of a possible inflection point, at approximately 400 g, suggested that two sensory channels may contribute to performance. If this is the case, the operative channel at low forces is almost certainly the slowly adapting type I (SA-I) channel, while another mechanoreceptor class, the SA-II nail unit, is a plausible mediator of the more accurate performance seen at high force levels. To test this two-channel hypothesis in experiment 2, we hydrated participants' thumbnails in order to reduce nail rigidity and thus prevent stimulation of underlying SA-II mechanoreceptors. This technique was found to reduce sensory accuracy in a force-matching task at high forces (1000 g) while leaving low force matching (100 g) unimpaired. Taken together, these results suggest that two sensory channels mediate the perception of fingertip forces in humans: one channel predominating at low forces (below approximately 400 g) and another responsible for perceiving high forces which is likely mediated by the SA-II nail unit.

Mental capacity, diagnosis and insight in psychiatric in-patients: a cross-sectional study.

PubMed

Owen, G S; David, A S; Richardson, G; Szmukler, G; Hayward, P; Hotopf, M

2009-08-01

Mental capacity is now a core part of UK mental health law and clinicians will increasingly be expected to assess it. Because it is a legal concept there is a need to clarify associations with variables that clinicians are more familiar with, especially insight. In this cross-sectional study we recruited consecutive psychiatric admissions to the Maudsley Hospital, London. We carried out structured assessments of decision making using the MacArthur Competence Assessment Tool for Treatment (MacCAT-T), resulting in a clinical judgement about capacity status. We analysed associations with a range of sociodemographic and clinical variables, including insight score on the Expanded Schedule for the Assessment of Insight (SAI-E). The same variables were compared in an analysis stratified according to diagnostic group: psychotic disorders/bipolar affective disorder (BPAD)/non-psychotic disorders. Psychotic disorders and manic episodes of BPAD are most strongly associated with incapacity. In such patients, insight is the best discriminator of capacity status. In patients with non-psychotic disorders, insight is less strongly associated with capacity; in this group depressed mood discriminates capacity status whereas it does not in psychotic disorders. Cognitive performance does not discriminate capacity status in patients with psychotic disorders. Mental capacity has complex relationships with psychopathological variables, and these relationships are different according to diagnostic group. Insight is the best discriminator of capacity status in psychotic disorders and BPAD but not in non-psychotic disorders.

Optical Monitoring of NGC4151 During 110 Years

NASA Astrophysics Data System (ADS)

Oknyanskij, V. L.; Metlova, N. V.; Huseynov, N. A.; Guo, Di-Fu; Lyuty, V. M.

We present the historical light curve of NGC 4151 for 1906-2016. The light curve (Oknyanskij and Lyuty, 2007) is primarily based on our published photoelectric data (1968-2007, about 1040 nightly mean measurements (Oknyanskij and Lyuty, 2007)) and photographic estimates (mostly Odessa and Moscow plates taken in 1906 - 1982 (Oknyanskij, 1978, 1983), about 350 measurements). Additionally, we include all data obtained prior to 1968 (de Vaucouleurs and de Vaucouleurs, 1968; Barnes 1968; Sandage, 1967; Wisniewski and Kleinmann, 1968; Fitch et al., 1967) in total, 19 photoelectric observations from 1958-1967, were reduced by us to the same diaphragm aperture as that used in our measurements) as well as photographic data (Pacholczyk et al., 1983) (Harvard and Steward observatories' patrol plates taken in 1910-1968, about 210 measurements). The light curve includes our old and new photometrical data obtained during last years at SAI, ShAO and Weihai Observatory as well as other published data (Roberts and Rumstey, 2012; Schnulle et al., 2015). All these data were reduced to an uniform photometric system.Applying Fourier (CLEAN algorithm) we have found periodic component ˜16 years in the 110 years light curve. 40 years ago about the same "period" was firstly reviled from Odessa's photometrical data (Oknyanskij, 1977; 1978). This "period" seen in the light curve was then found independently in the spectral variability and interpreted as a case of the supermassive binary black hole (Bon et al., 2012). We interpret these circles as some accretion dynamic time.

[Patients' decision for aesthetic surgery].

PubMed

Fansa, H; Haller, S

2011-12-01

. Influence on patients' decision is only possible by high quality operation results, which in turn lead to good reputation with (non-aesthetic) physicians and patients. In contrast to print advertisements, the provision of information via the internet is of tremendous importance and must be both information and comprehensible. Not only the aesthetic result should be depicted, but also questions such as "when will I be fit after surgery", and possible problems and complications should be described honestly. Besides the described word-of-mouth recommendations web fora resemble a virtual extension of recommendation. Whether such web based fora will prevail as a significant source of information remains unclear. Board certification in plastic and aesthetic surgery ("Facharzt" qualification) was assessed as very important. Thus, this is relevant information which should be emphasized. Most important for the patients' decision, however, was patient-doctor communication. To develop a basis of trust, communication should be open and reliable. An adequate time span has to be planned for the first appointment with the patient. In addition to aesthetic results, risks and possible complications have to be discussed. An open and comprehensible conversation which does not sugar-coat the operation is assessed as very positive. Finally, based on this consultation the surgeon is suggestive of his surgical competence. This underlines that core competence in aesthetic surgery is a medical one. © Georg Thieme Verlag KG Stuttgart · New York.

The ethics of complexity. Genetics and autism, a literature review.

PubMed

Hens, Kristien; Peeters, Hilde; Dierickx, Kris

2016-04-01

It is commonly believed that the etiology of autism is at least partly explained through genetics. Given the complexity of autism and the variability of the autistic phenotype, genetic research and counseling in this field are also complex and associated with specific ethical questions. Although the ethics of autism genetics, especially with regard to reproductive choices, has been widely discussed on the public fora, an in depth philosophical or bioethical reflection on all aspects of the theme seems to be missing. With this literature review we wanted to map the basic questions and answers that exist in the bioethical literature on autism genetics, research, counseling and reproduction, and provide suggestions as to how the discussion can proceed. We found 19 papers that fitted the description of "bioethics literature focusing on autism genetics," and analyzed their content to distill arguments and themes. We concluded that because of the complexity of autism, and the uncertainty with regard to its status, more ethical reflection is needed before definite conclusions and recommendations can be drawn. Moreover, there is a dearth of bioethical empirical studies querying the opinions of all parties, including people with autism themselves. Such empirical bioethical studies should be urgently done before bioethical conclusions regarding the aims and desirability of research into autism genes can be done. Also, fundamental philosophical reflection on concepts of disease should accompany research into the etiology of autism. © 2016 Wiley Periodicals, Inc.

Assessing the impact of the Australia-United States Free Trade Agreement on Australian and global medicines policy

PubMed Central

Faunce, Thomas; Doran, Evan; Henry, David; Drahos, Peter; Searles, Andrew; Pekarsky, Brita; Neville, Warwick

2005-01-01

On 1 January 2005, a controversial trade agreement entered into force between Australia and the United States. Though heralded by the parties as facilitating the removal of barriers to free trade (in ways not achievable in multilateral fora), it also contained many trade-restricting intellectual property provisions and others uniquely related to altering pharmaceutical regulation and public health policy in Australia. The latter appear to have particularly focused on the world-respected process of federal government reimbursement after expert cost-effectiveness evaluation, popularly known as the Pharmaceutical Benefits Scheme ('PBS'). It remains uncertain what sort of impacts – if any – the Australia-United States Free Trade Agreement ('AUSFTA') will have on PBS processes such as reference pricing and their important role in facilitating equitable and affordable access to essential medicines. This is now the field of inquiry for a major three year Australian Research Council ('ARC')-funded study bringing together a team of senior researchers in regulatory theory from the Australian National University and pharmacoeconomics from the University of Newcastle. The project proposes to monitor, assess and analyse the real and potential impacts of the AUSFTA in this area, providing Australian policy-makers with continuing expertise and options. To the extent that the AUSFTA medicines provisions may represent an important precedent in a global strategy by industry on cost-effectiveness evaluation of pharmaceuticals, the study will also be of great interest to policy makers in other jurisdictions. PMID:16209703

From "Special K" to "Special M": the evolution of the recreational use of ketamine and methoxetamine.

PubMed

Corazza, Ornella; Assi, Sulaf; Schifano, Fabrizio

2013-06-01

This article reviews the recreational use of ketamine ("Special K"; KET) and explores the recent diffusion of its new derivative methoxetamine ("Special M"; MXE). The literature search on the nonclinical/recreational use of KET and MXE was carried out in a range of medical databases. Considering the limitations of peer-reviewed information, data were integrated with a qualitative assessment of a range of websites, drug fora, and other online resources including e-newsgroups, chat rooms, mailing lists, e-newsletters, and bulletin boards. The recreational use of KET has started since its discovery in 1962. This was due to its rapid onset, short duration of action, and peculiar psychotropic effects ("K-hole"). The latter effect ranges from confusion to dissociation and depersonalization (near-death experience). However, KET abuse is often associated with physical and psychological side effects, of which the worst is urological/bladder toxicity. Recently, MXE has emerged as a legal and "bladder-friendly" KET alternative. MXE presents with the same dissociative effect of KET, but with slower onset and longer duration of action. However, MXE seems to be associated with worse side effects than KET, ranging from mood disturbances/suicidal attempts to acute cerebellar toxicity. After 50 years of its discovery, KET has led to the emergence of MXE. However, this latter derivative does not appear to be a safer alternative to KET itself. © 2013 John Wiley & Sons Ltd.

From micronutrient recommendations to policy: consumer and stakeholder involvement.

PubMed

Timotijevic, L; Raats, M M; Barnett, J; Brown, K; Shepherd, R; Fernandez, L; Dömölki, L; Ruprich, J; Sonne, A-M; Hermoso, M; Koletzko, B; Frost-Andersen, L; Timmer, A

2010-06-01

To achieve the nutritional goals stipulated by micronutrient recommendations, greater attention must be paid to the behavioural routes to such nutritional outcomes. Coopting stakeholders and consumers into decisions regarding micronutrient recommendations is an important step towards achieving a greater link between micronutrient recommendations and behaviour. This study aims to examine the rationale and processes associated with consumer and stakeholder involvement in setting micronutrient recommendations across Europe. Using the contacts established through the Eurreca network of excellence (commissioned by the European Commission), the research involved in-depth desk research of key documents and communication channels linked to the process of setting micronutrient recommendations across seven countries: the United Kingdom, Norway, Denmark, Germany, Spain, the Czech Republic and Hungary. Stakeholder engagement is recognized by most countries as an important aspect of the process of setting micronutrient recommendations and their translation into policy, although there is notable variation in the extent to which this has been achieved across the seven countries and its effect on final decisions. Stakeholders were not involved at the outset of the process ('framing' of the problem) in any of the countries, and there was no evidence of consumer involvement and open public fora. Some of the key explanatory factors for diversity in the degree of involvement include historical sociopolitical context; the extent to which food and nutrition are key policy agenda; and the relative power of stakeholders in influencing food and nutrition policy.

Collaboration between traditional practitioners and primary health care staff in South Africa: developing a workable partnership for community mental health services.

PubMed

Campbell-Hall, Vicky; Petersen, Inge; Bhana, Arvin; Mjadu, Sithembile; Hosegood, Victoria; Flisher, Alan J

2010-09-01

The majority of the black African population in South Africa utilize both traditional and public sector Western systems of healing for mental health care. There is a need to develop models of collaboration that promote a workable relationship between the two healing systems. The aim of this study was to explore perceptions of service users and providers of current interactions between the two systems of care and ways in which collaboration could be improved in the provision of community mental health services. Qualitative individual and focus group interviews were conducted with key health care providers and service users in one typical rural South African health sub-district. The majority of service users held traditional explanatory models of illness and used dual systems of care, with shifting between treatment modalities reportedly causing problems with treatment adherence. Traditional healers expressed a lack of appreciation from Western health care practitioners but were open to training in Western biomedical approaches and establishing a collaborative relationship in the interests of improving patient care. Western biomedically trained practitioners were less interested in such an arrangement. Interventions to acquaint traditional practitioners with Western approaches to the treatment of mental illness, orientation of Western practitioners towards a culture-centred approach to mental health care, as well as the establishment of fora to facilitate the negotiation of respectful collaborative relationships between the two systems of healing are required at district level to promote an equitable collaboration in the interests of improved patient care.

Consensus Seasonal Flood Forecasts and Warning Response System (FFWRS): an alternate for nonstructural flood management in Bangladesh.

PubMed

Chowdhury, Rashed

2005-06-01

Despite advances in short-range flood forecasting and information dissemination systems in Bangladesh, the present system is less than satisfactory. This is because of short lead-time products, outdated dissemination networks, and lack of direct feedback from the end-user. One viable solution is to produce long-lead seasonal forecasts--the demand for which is significantly increasing in Bangladesh--and disseminate these products through the appropriate channels. As observed in other regions, the success of seasonal forecasts, in contrast to short-term forecast, depends on consensus among the participating institutions. The Flood Forecasting and Warning Response System (henceforth, FFWRS) has been found to be an important component in a comprehensive and participatory approach to seasonal flood management. A general consensus in producing seasonal forecasts can thus be achieved by enhancing the existing FFWRS. Therefore, the primary objective of this paper is to revisit and modify the framework of an ideal warning response system for issuance of consensus seasonal flood forecasts in Bangladesh. The five-stage FFWRS-i) Flood forecasting, ii) Forecast interpretation and message formulation, iii) Warning preparation and dissemination, iv) Responses, and v) Review and analysis-has been modified. To apply the concept of consensus forecast, a framework similar to that of the Southern African Regional Climate Outlook Forum (SARCOF) has been discussed. Finally, the need for a climate Outlook Fora has been emphasized for a comprehensive and participatory approach to seasonal flood hazard management in Bangladesh.

Effects of seawater acidification on a coral reef meiofauna community

NASA Astrophysics Data System (ADS)

Sarmento, V. C.; Souza, T. P.; Esteves, A. M.; Santos, P. J. P.

2015-09-01

Despite the increasing risk that ocean acidification will modify benthic communities, great uncertainty remains about how this impact will affect the lower trophic levels, such as members of the meiofauna. A mesocosm experiment was conducted to investigate the effects of water acidification on a phytal meiofauna community from a coral reef. Community samples collected from the coral reef subtidal zone (Recife de Fora Municipal Marine Park, Porto Seguro, Bahia, Brazil), using artificial substrate units, were exposed to a control pH (ambient seawater) and to three levels of seawater acidification (pH reductions of 0.3, 0.6, and 0.9 units below ambient) and collected after 15 and 30 d. After 30 d of exposure, major changes in the structure of the meiofauna community were observed in response to reduced pH. The major meiofauna groups showed divergent responses to acidification. Harpacticoida and Polychaeta densities did not show significant differences due to pH. Nematoda, Ostracoda, Turbellaria, and Tardigrada exhibited their highest densities in low-pH treatments (especially at the pH reduction of 0.6 units, pH 7.5), while harpacticoid nauplii were strongly negatively affected by low pH. This community-based mesocosm study supports previous suggestions that ocean acidification induces important changes in the structure of marine benthic communities. Considering the importance of meiofauna in the food web of coral reef ecosystems, the results presented here demonstrate that the trophic functioning of coral reefs is seriously threatened by ocean acidification.

Effects of unstable shoes on chronic low back pain in health professionals: a randomized controlled trial.

PubMed

Armand, Stéphane; Tavcar, Ziva; Turcot, Katia; Allet, Lara; Hoffmeyer, Pierre; Genevay, Stéphane

2014-12-01

The aim of this study was to evaluate the effectiveness of unstable shoes in reducing low back pain in health professionals. Of a volunteer sample of 144 participants, 40 with nonspecific chronic low back pain were eligible and enrolled in this study. Participants were randomized to an intervention group, who wore unstable shoes (model MBT Fora), or a control group, who wore conventional sports shoes (model Adidas Bigroar). The participants had to wear the study shoes during their work hours, and at least 6 hours per workday, over a period of 6 weeks. The primary outcome was low back pain assessed on a Visual Analog Scale. The secondary outcomes were patient satisfaction, disability evaluated using Roland-Morris questionnaire and quality of life evaluated using EQ-VAS. The intervention group showed a significant decrease in pain scores compared to the control group. The rate of satisfaction was higher in the intervention group (79%) compared to the control group (25%). There was no significant difference for the Roland-Morris disability questionnaire score and the EQ-VAS scale. The results of this clinical trial suggest that wearing unstable shoes for 6 weeks significantly decreases low back pain in patients suffering from chronic low back pain but had no significant effect on quality of life and disability scores. Copyright © 2014 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

Recreational Use, Analysis and Toxicity of Tryptamines

PubMed Central

Tittarelli, Roberta; Mannocchi, Giulio; Pantano, Flaminia; Romolo, Francesco Saverio

2015-01-01

The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a “legal” alternative to internationally controlled drugs. There are many categories of NPS, such as synthetic cannabinoids, synthetic cathinones, phenylethylamines, piperazines, ketamine derivatives and tryptamines. Tryptamines are naturally occurring compounds, which can derive from the amino acid tryptophan by several biosynthetic pathways: their structure is a combination of a benzene ring and a pyrrole ring, with the addition of a 2-carbon side chain. Tryptamines include serotonin and melatonin as well as other compounds known for their hallucinogenic properties, such as psilocybin in ‘Magic mushrooms’ and dimethyltryptamine (DMT) in Ayahuasca brews. Aim: To review the scientific literature regarding tryptamines and their derivatives, providing a summary of all the available information about the structure of these compounds, their effects in relationship with the routes of administration, their pharmacology and toxicity, including articles reporting cases of death related to intake of these substances. Methods: A comprehensive review of the published scientific literature was performed, using also non peer-reviewed information sources, such as books, government publications and drug user web fora. Conclusions: Information from Internet and from published scientific literature, organized in the way we proposed in this review, provides an effective tool for specialists facing the emerging NPS threat to public health and public security, including the personnel working in Emergency Department. PMID:26074742

Hominin track assemblages from Okote Member deposits near Ileret, Kenya, and their implications for understanding fossil hominin paleobiology at 1.5 Ma.

PubMed

Hatala, Kevin G; Roach, Neil T; Ostrofsky, Kelly R; Wunderlich, Roshna E; Dingwall, Heather L; Villmoare, Brian A; Green, David J; Braun, David R; Harris, John W K; Behrensmeyer, Anna K; Richmond, Brian G

2017-11-01

Tracks can provide unique, direct records of behaviors of fossil organisms moving across their landscapes millions of years ago. While track discoveries have been rare in the human fossil record, over the last decade our team has uncovered multiple sediment surfaces within the Okote Member of the Koobi Fora Formation near Ileret, Kenya that contain large assemblages of ∼1.5 Ma fossil hominin tracks. Here, we provide detailed information on the context and nature of each of these discoveries, and we outline the specific data that are preserved on the Ileret hominin track surfaces. We analyze previously unpublished data to refine and expand upon earlier hypotheses regarding implications for hominin anatomy and social behavior. While each of the track surfaces discovered at Ileret preserves a different amount of data that must be handled in particular ways, general patterns are evident. Overall, the analyses presented here support earlier interpretations of the ∼1.5 Ma Ileret track assemblages, providing further evidence of large, human-like body sizes and possibly evidence of a group composition that could support the emergence of certain human-like patterns of social behavior. These data, used in concert with other forms of paleontological and archaeological evidence that are deposited on different temporal scales, offer unique windows through which we can broaden our understanding of the paleobiology of hominins living in East Africa at ∼1.5 Ma. Copyright © 2017 Elsevier Ltd. All rights reserved.

Nutritional profile of hemodialysis patients concerning treatment time.

PubMed

Alvarenga, Livia de Almeida; Andrade, Bárbara Danelon; Moreira, Michelle Andrade; Nascimento, Roberto de Paula; Macedo, Isabela Dariú; Aguiar, Aline Silva de

2017-01-01

The mortality of the population with chronic kidney disease (CKD) on hemodialysis (HD) is very high and the protein-energy malnutrition stands out as one of the most common consequences in relation to this condition. To evaluate the association between time of hemodialysis and nutritional parameters of patients. It is a cross-sectional study with secondary data, developed of the University Hospital of the Federal University of Juiz de Fora (HU/UFJF). This study was approved by the Research Ethics Committee (Nº 1.233.142), a total of 36 patients. The medical records and collected data were analyzed for anthropometric markers, biochemical and diet, considering two groups: HD time less than three and greater than or equal to three years. There was reduction of mass of somatic protein with increased duration of HD. In relation to food intake was observed that in patients with increased duration of dialysis, an increase in average consumption of protein / kg of weight, calories, phosphorus and potassium, with a significant difference from the mean protein intake / kg (p = 0.04) and phosphorus (p = 0.045). Increasing HD time has altered body composition of patients, indicating a decline in the nutritional status of these individuals. HD patients are a risk group for protein-energy malnutrition, where HD time interferes with the nutritional status and food profile of the patient. The group HD time greater than or equal to 3 years presented worsening nutritional status.

What does "success" in public engagement activities mean? A comparison of goals, motivations and embedded assumptions in four polar outreach activities.

NASA Astrophysics Data System (ADS)

Roop, H. A.; Salmon, R. A.

2015-12-01

Using four very different polar outreach case studies, we will discuss scientists' motivations, expectations, and institutional incentives (and dis-incentives) to engage with the public, and argue that improved training, evaluation, and academic value needs to be associated with scientist-led communication efforts - as well as clearer fora for sharing best practice in this field. We will illustrate our argument using examples from an Antarctic festival with public lectures and science cafes, outreach associated with an Antarctic expedition, the global launch of a climate change documentary that had a significant focus on Antarctica, and a series of "Polar Weeks" led by an international community of scientists and educators. While there is an excellent culture of accountability in both formal and informal science communication sectors, the same rigour is not applied to the majority of 'outreach' activities that are initiated by the science research community. Many of these activities are undertaken based on 'what feels right' and opportunism, and are proclaimed to be a success based on little or no formal evaluation. As a result, much of this work goes undocumented, is not evaluated from the perspective of the science community, and is rarely subject to peer-review and its associated benefits, including professional rewards. We therefore recommend new opportunities for publication in this field that would encourage science communication theory and practice to better inform each other, and for scientists to gain professional recognition for their efforts in this arena.

Why do scientists do outreach, what do we achieve, and how can we better learn from each other, and from research in this field?

NASA Astrophysics Data System (ADS)

Salmon, R. A.; Roop, H. A.

2014-12-01

Using four very different polar outreach case studies, we will discuss scientists' motivations, expectations, and institutional incentives (and dis-incentives) to engage with the public, and argue that improved training, evaluation, and academic value needs to be associated with scientist-led communication efforts - as well as clearer fora for sharing best practice in this field. We will illustrate our argument using examples from an Antarctic festival with public lectures and science cafes, outreach associated with an Antarctic expedition, the global launch of a climate change documentary that had a significant focus on Antarctica, and a series of "Polar Weeks" led by an international community of scientists and educators. While there is an excellent culture of accountability in both formal and informal science communication sectors, the same rigour is not applied to the majority of 'outreach' activities that are initiated by the science research community. Many of these activities are undertaken based on 'what feels right' and opportunism, and are proclaimed to be a success based on little or no formal evaluation. As a result, much of this work goes undocumented, is not evaluated from the perspective of the science community, and is rarely subject to peer-review and its associated benefits, including professional rewards. We therefore conclude with suggestions of new opportunities for publication in this field that would encourage science communication theory and practice to better inform each other, and for scientists to gain professional recognition for their efforts in this arena.

UK policy on social networking sites and online health: From informed patient to informed consumer?

PubMed Central

Hunt, Daniel; Koteyko, Nelya; Gunter, Barrie

2015-01-01

Background Social networking sites offer new opportunities for communication between and amongst health care professionals, patients and members of the public. In doing so, they have the potential to facilitate public access to health care information, peer-support networks, health policy fora and online consultations. Government policies and guidance from professional organisations have begun to address the potential of these technologies in the domain of health care and the responsibilities they entail for their users. Objective Adapting a discourse analytic framework for the analysis of policy documents, this review paper critically examines discussions of social networking sites in recent government and professional policy documents. It focuses particularly on who these organisations claim should use social media, for what purposes, and what the anticipated outcomes of use will be for patients and the organisations themselves. Conclusion Recent policy documents have configured social media as a new means with which to harvest patient feedback on health care encounters and communicate health care service information with which patients and the general public can be ‘empowered’ to make responsible decisions. In orienting to social media as a vehicle for enabling consumer choice, these policies encourage the marketization of health information through a greater role for non-profit and commercial organisations in the eHealth domain. At the same time, current policy largely overlooks the role of social media in mediating ongoing support and self-management for patients with long-term conditions. PMID:29942541

Biophysical drivers of seasonal variability in Sphagnum gross primary production in a northern temperate bog

DOE PAGES

Sebestyen, Stephen D.; Norby, Richard J.; Hanson, Paul J.; ...

2017-04-18

Sphagnum mosses are the keystone species of peatland ecosystems. With rapid rates of climate change occurring in high latitudes, vast reservoirs of carbon accumulated over millennia in peatland ecosystems are potentially vulnerable to rising temperature and changing precipitation. We investigate the seasonal drivers of Sphagnum gross primary production (GPP)—the entry point of carbon into wetland ecosystems. Continuous flux measurements and flux partitioning show a seasonal cycle of Sphagnum GPP that peaked in the late summer, well after the peak in photosynthetically active radiation. Wavelet analysis showed that water table height was the key driver of weekly variation in Sphagnum GPPmore » in the early summer and that temperature was the primary driver of GPP in the late summer and autumn. Flux partitioning and a process-based model of Sphagnum photosynthesis demonstrated the likelihood of seasonally dynamic maximum rates of photosynthesis and a logistic relationship between the water table and photosynthesizing tissue area when the water table was at the Sphagnum surface. Here, the model also suggested that variability in internal resistance to CO 2 transport, a function of Sphagnum water content, had minimal effect on GPP. To accurately model Sphagnum GPP, we recommend the following: (1) understanding seasonal photosynthetic trait variation and its triggers in Sphagnum; (2) characterizing the interaction of Sphagnum photosynthesizing tissue area with water table height; (3) modeling Sphagnum as a “soil” layer for consistent simulation of water dynamics; and (4) measurement of Sphagnum “canopy” properties: extinction coefficient (k), clumping (Ω), and maximum stem area index (SAI).« less

Impact of Future Climate and Development on Agricultural Water Management: A Case Study of the Huai Sat Bat Sub-basin in Northeastern Thailand

NASA Astrophysics Data System (ADS)

Polpanich, O. U.; Lyon, S. W.; Krittasudthacheewa, C.; Bush, A. L.; Kemp-Benedict, E.

2016-12-01

In this study, we used the Water Evaluation And Planning (WEAP) model to provide a participatory framework to outline choices (and consequences) for river managers, stakeholders and policy makers. The water balance was created for the data-limited Huay Sai Bat (HSB) sub-basin located in northeastern Thailand. Leveraging the involvement of stakeholders, we developed an appropriate representation of the catchment hydrology utilizing the best available data. In addition, WEAP allowed for simulation of impacts from alternative scenarios of climate change, land-use development and water resource management in HSB. These scenarios were developed iteratively across several participatory exercises. Our modeling results indicate that regional climatic changes tend to increase streamflow during the wet (monsoon) season while land-use and management changes only had minor impacts on streamflow. However, the scenarios of land-use and management changes, specifically those reflecting increases in irrigated rice and sugarcane production and/or shifts toward small-scale or regional irrigation schemes, lead to relatively large unmet water demands (particularly during the dry season). In addition, and perhaps more importantly, the WEAP modeling facilitated communication with stakeholders across various management levels, allowing for assessment of the main concerns surrounding ongoing and future potential changes in HSB. The outcomes of these interactions were then used to formulate recommendations addressing potential gaps between policy and implementation. The study indicates that a participatory modeling approach is a promising way of incorporating problem-relevant knowledge and values of stakeholders to influence decisions as well as strengthen civic capacity.

Biophysical drivers of seasonal variability in Sphagnum gross primary production in a northern temperate bog

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sebestyen, Stephen D.; Norby, Richard J.; Hanson, Paul J.

Sphagnum mosses are the keystone species of peatland ecosystems. With rapid rates of climate change occurring in high latitudes, vast reservoirs of carbon accumulated over millennia in peatland ecosystems are potentially vulnerable to rising temperature and changing precipitation. We investigate the seasonal drivers of Sphagnum gross primary production (GPP)—the entry point of carbon into wetland ecosystems. Continuous flux measurements and flux partitioning show a seasonal cycle of Sphagnum GPP that peaked in the late summer, well after the peak in photosynthetically active radiation. Wavelet analysis showed that water table height was the key driver of weekly variation in Sphagnum GPPmore » in the early summer and that temperature was the primary driver of GPP in the late summer and autumn. Flux partitioning and a process-based model of Sphagnum photosynthesis demonstrated the likelihood of seasonally dynamic maximum rates of photosynthesis and a logistic relationship between the water table and photosynthesizing tissue area when the water table was at the Sphagnum surface. Here, the model also suggested that variability in internal resistance to CO 2 transport, a function of Sphagnum water content, had minimal effect on GPP. To accurately model Sphagnum GPP, we recommend the following: (1) understanding seasonal photosynthetic trait variation and its triggers in Sphagnum; (2) characterizing the interaction of Sphagnum photosynthesizing tissue area with water table height; (3) modeling Sphagnum as a “soil” layer for consistent simulation of water dynamics; and (4) measurement of Sphagnum “canopy” properties: extinction coefficient (k), clumping (Ω), and maximum stem area index (SAI).« less

Biophysical drivers of seasonal variability in Sphagnum gross primary production in a northern temperate bog

NASA Astrophysics Data System (ADS)

Walker, Anthony P.; Carter, Kelsey R.; Gu, Lianhong; Hanson, Paul J.; Malhotra, Avni; Norby, Richard J.; Sebestyen, Stephen D.; Wullschleger, Stan D.; Weston, David J.

2017-05-01

Sphagnum mosses are the keystone species of peatland ecosystems. With rapid rates of climate change occurring in high latitudes, vast reservoirs of carbon accumulated over millennia in peatland ecosystems are potentially vulnerable to rising temperature and changing precipitation. We investigate the seasonal drivers of Sphagnum gross primary production (GPP)—the entry point of carbon into wetland ecosystems. Continuous flux measurements and flux partitioning show a seasonal cycle of Sphagnum GPP that peaked in the late summer, well after the peak in photosynthetically active radiation. Wavelet analysis showed that water table height was the key driver of weekly variation in Sphagnum GPP in the early summer and that temperature was the primary driver of GPP in the late summer and autumn. Flux partitioning and a process-based model of Sphagnum photosynthesis demonstrated the likelihood of seasonally dynamic maximum rates of photosynthesis and a logistic relationship between the water table and photosynthesizing tissue area when the water table was at the Sphagnum surface. The model also suggested that variability in internal resistance to CO2 transport, a function of Sphagnum water content, had minimal effect on GPP. To accurately model Sphagnum GPP, we recommend the following: (1) understanding seasonal photosynthetic trait variation and its triggers in Sphagnum; (2) characterizing the interaction of Sphagnum photosynthesizing tissue area with water table height; (3) modeling Sphagnum as a "soil" layer for consistent simulation of water dynamics; and (4) measurement of Sphagnum "canopy" properties: extinction coefficient (k), clumping (Ω), and maximum stem area index (SAI).

Poetry, Nature and Science: Romantic Nature Philosophy in the Works of Novalis and E. T. a. Hoffmann

NASA Astrophysics Data System (ADS)

Weisend, Ausma Skerbele

The nature philosophy of the early Romantic period in Germany attempted to find a synthesis of science and philosophy in a new philosophy of nature. This philosophy was first formulated by F. W. J. Schelling and influenced by the galvanic experiments of J. W. Ritter. Novalis is a unique figure in romanticism since he combines scientific expertise with philosophical insight and poetic imagination. In Lehrlinge zu Sais he explores the significance of nature's language and presents different relationships between man and nature. Novalis thinks that a synthesis of all divergent elements in nature and society is necessary to transform the world. In Klingsohrs Marchen this transformation is accomplished by poetic activation of the physical sciences and by the power of love. After 1800 the romantic movement becomes interested in the problems of subconscious and abnormal psychological states, which are seen as contacts with a more spiritual level of existence. These ideas, expressed in a popular form by G. H. Schubert, provide a rich source of materials for E. T. A. Hoffmann, who elevates the realms of poetry and music in his fairy tales, but sees only negative qualities in science. Hoffmann's protagonists find that love, music, and poetry are the greatest forces in life. The figure of the scientist becomes an evil magician with no regard for human values. The romantic movement failed to unite the values of humanities with the insights of physical sciences. The problem of autonomy isolates both modern science and modern literature from the ethical values of society.

Dopaminergic Modulation of Cortical Plasticity in Alzheimer's Disease Patients

PubMed Central

Koch, Giacomo; Di Lorenzo, Francesco; Bonnì, Sonia; Giacobbe, Viola; Bozzali, Marco; Caltagirone, Carlo; Martorana, Alessandro

2014-01-01

In animal models of Alzheimer's disease (AD), mechanisms of cortical plasticity such as long-term potentiation (LTP) and long-term depression (LTD) are impaired. In AD patients, LTP-like cortical plasticity is abolished, whereas LTD seems to be preserved. Dopaminergic transmission has been hypothesized as a new player in ruling mechanisms of cortical plasticity in AD. We aimed at investigating whether administration of the dopamine agonist rotigotine (RTG) could modulate cortical plasticity in AD patients, as measured by theta burst stimulation (TBS) protocols of repetitive transcranial stimulation applied over the primary motor cortex. Thirty mild AD patients were tested in three different groups before and after 4 weeks of treatment with RTG, rivastigmine (RVT), or placebo (PLC). Each patient was evaluated for plasticity induction of LTP/LTD-like effects using respectively intermittent TBS (iTBS) or continuous TBS protocols. Short-latency afferent inhibition (SAI) protocol was performed to indirectly assess central cholinergic activity. A group of age-matched healthy controls was recruited for baseline comparisons. Results showed that at baseline, AD patients were characterized by impaired LTP-like cortical plasticity, as assessed by iTBS. These reduced levels of LTP-like cortical plasticity were increased and normalized after RTG administration. No effect was induced by RVT or PLC on LTP. LTD-like cortical plasticity was not modulated in any condition. Cholinergic activity was increased by both RTG and RVT. Our findings reveal that dopamine agonists may restore the altered mechanisms of LTP-like cortical plasticity in AD patients, thus providing novel implications for therapies based on dopaminergic stimulation. PMID:24859851

Profile and follow-up of patients with tuberculosis in a priority city in Brazil

PubMed Central

Pereira, Jisleny da Cruz; Silva, Marcio Roberto; da Costa, Ronaldo Rodrigues; Guimarães, Mark Drew Crosland; Leite, Isabel Cristina Gonçalves

2015-01-01

OBJECTIVE To analyze the cases of tuberculosis and the impact of direct follow-up on the assessment of treatment outcomes. METHODS This open prospective cohort study evaluated 504 cases of tuberculosis reported in the Sistema de Informação de Agravos de Notificação (SINAN – Notifiable Diseases Information System) in Juiz de Fora, MG, Southeastern Brazil, between 2008 and 2009. The incidence of treatment outcomes was compared between a group of patients diagnosed with tuberculosis and directly followed up by monthly consultations during return visits (287) and a patient group for which the information was indirectly collected (217) through the city’s surveillance system. The Chi-square test was used to compare the percentages, with a significance level of 0.05. The relative risk (RR) was used to evaluate the differences in the incidence rate of each type of treatment outcome between the two groups. RESULTS Of the outcomes directly and indirectly evaluated, 18.5% and 3.2% corresponded to treatment default and 3.8% and 0.5% corresponded to treatment failure, respectively. The incidence of treatment default and failure was higher in the group with direct follow-up (p < 0.05) (RR = 5.72, 95%CI 2.65;12.34, and RR = 8.31, 95%CI 1.08;63.92, respectively). CONCLUSIONS A higher incidence of treatment default and failure was observed in the directly followed up group, and most of these cases were neglected by the disease reporting system. Therefore, effective measures are needed to improve the control of tuberculosis and data quality. PMID:25741659

Is Sustainable Remediation Now a Self-Sustaining Process? an International Progress Report

NASA Astrophysics Data System (ADS)

Smith, J. W. N.

2014-12-01

Sustainable remediation - the consideration of environmental, social and economic factors associated with soil and groundwater risk-management options, to help select the best overall solution - has been a rapidly evolving topic in recent years. The first published reference[1] to 'sustainable remediation' was in the title of a 1999 conference paper by Kearney et al., (1999), but activity really accelerated in the middle-late 2000's, with establishment of a number of collaborative sustainable remediation groups and fora, and increased publication rates in the peer reviewed literature (Fig 1). Figure 1. Journal paper publications with search term 'sustainable remediation' (SCOPUS survey, 17 July 2014) This presentation will review the international progress of sustainable remediation concept development and application in regulatory and corporate decision-making processes. It will look back at what has already been achieved, provide an update on the latest initiatives and developments, and look forward to what the future of sustainable remediation might look like. Specifically it will describe: Sustainable remediation frameworks: synergies and international collaboration; Latest guidance and tools developed by the various sustainable remediation organisations (SuRFs), including the SuRF-UK Best Management Practices and Tier 1 Briefcase; Best practice standard development by ASTM and ISO; Regulatory acceptance of sustainable remediation, including incorporation into legislation, and the NICOLE - Common Forum Joint statement on 'risk-informed and sustainable remediation' in Europe; Examples of corporate adoption of sustainable remediation principles. The presentation will conclude with a look forward to a vision of sustainable remediation in 2020.

Promoting innovation and excellence to face the rapid diffusion of novel psychoactive substances in the EU: the outcomes of the ReDNet project.

PubMed

Corazza, Ornella; Assi, Sulaf; Simonato, Pierluigi; Corkery, John; Bersani, Francesco Saverio; Demetrovics, Zsolt; Stair, Jacqueline; Fergus, Suzanne; Pezzolesi, Cinzia; Pasinetti, Manuela; Deluca, Paolo; Drummond, Colin; Davey, Zoe; Blaszko, Ursula; Moskalewicz, Jacek; Mervo, Barbara; Furia, Lucia Di; Farre, Maggi; Flesland, Liv; Pisarska, Agnieszka; Shapiro, Harry; Siemann, Holger; Skutle, Arvid; Sferrazza, Elias; Torrens, Marta; Sambola, F; van der Kreeft, Peer; Scherbaum, Norbert; Schifano, Fabrizio

2013-07-01

The recent emergence of new psychoactive compounds (novel psychoactive substances (NPS)) has raised prominent challenges in the fields of drug policy, substance use research, public health and service provision. The Recreational Drugs European Network project, funded by the European Commission, was implemented to improve the information stream to young people and professionals about effects/risks of NPS by identifying online products and disseminating relevant information through technological tools. Regular multilingual qualitative assessments of websites, drugs fora and other online resources were carried out using the Google search engine in eight languages from collaborating countries. These included the following: the UK, Norway, Belgium, Germany, Hungary, Poland, Italy and Spain. Products were tested and prevention messages were developed and disseminated via technological tools such as interactive websites, SMS alert, social networking (Facebook, Twitter), Multimedia (You Tube), Smartphone applications (iPhone) and virtual learning environments (Second Life). The Recreational Drugs European Network project established itself as the first Europe-wide prevention programme designed for NPS based on the efficacy of novel information and communication technology-based forms of intervention. More than 650 NPS products and combinations were identified; relevant information was disseminated to target population and advice was given to both European Union/international agencies and national policy makers. Web-monitoring activities are essential for mapping the diffusion of NPS and the use of technological tools can be successfully incorporated in specific prevention programmes. Furthermore, the involvement of multi-disciplinary international partnerships was and continues to be fundamental for responding to such a prominent challenge. Copyright © 2013 John Wiley & Sons, Ltd.

Assessment of the quality of patient-orientated internet information on surgery for ulcerative colitis.

PubMed

Sacchi, M; Yeung, T M; Spinelli, A; Mortensen, N J

2015-06-01

This study examines the quality of websites providing information on ulcerative colitis, including treatment options and surgery. Two search engines (Google and Yahoo) and the search term 'surgery for ulcerative colitis' were used. The first 50 sites obtained with each search engine were assessed. Sites were evaluated for content and scored using the DISCERN instrument, which evaluates the quality of health information on treatment choices. One hundred sites were examined, of which 14 were duplicates. Of the remainder, 58 provided patient-orientated information for adults and one site provided information for surgery in children. The other 27 sites included six scientific articles, three blogs, three links, six resources for clinicians, five fora, two video links and two dead links. Of the 58 websites that provided patient information for adults, only 26 (44.8%) had been updated within the last 2 years. Only 13/58 (22.4%) were affiliated to hospitals and clinics. Most sites (38/58, 65.5%) were associated with private companies with commercial interests. Although most websites contained information on symptoms and treatment options for ulcerative colitis, 37 (63.8%) did not describe any of the risks of surgery. Overall, only seven (12.1%) websites were identified as being 'good' or 'excellent' using the DISCERN criteria. The quality of patient information on surgery for ulcerative colitis is highly variable. There is potential for internet provision of valuable information and clinicians should guide patients with to access high-quality websites. Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland.

Is exposure to formaldehyde in air causally associated with leukemia?—A hypothesis-based weight-of-evidence analysis

PubMed Central

Rhomberg, Lorenz R; Bailey, Lisa A; Goodman, Julie E; Hamade, Ali K; Mayfield, David

2011-01-01

Recent scientific debate has focused on the potential for inhaled formaldehyde to cause lymphohematopoietic cancers, particularly leukemias, in humans. The concern stems from certain epidemiology studies reporting an association, although particulars of endpoints and dosimetry are inconsistent across studies and several other studies show no such effects. Animal studies generally report neither hematotoxicity nor leukemia associated with formaldehyde inhalation, and hematotoxicity studies in humans are inconsistent. Formaldehyde's reactivity has been thought to preclude systemic exposure following inhalation, and its apparent inability to reach and affect the target tissues attacked by known leukemogens has, heretofore, led to skepticism regarding its potential to cause human lymphohematopoietic cancers. Recently, however, potential modes of action for formaldehyde leukemogenesis have been hypothesized, and it has been suggested that formaldehyde be identified as a known human leukemogen. In this article, we apply our hypothesis-based weight-of-evidence (HBWoE) approach to evaluate the large body of evidence regarding formaldehyde and leukemogenesis, attending to how human, animal, and mode-of-action results inform one another. We trace the logic of inference within and across all studies, and articulate how one could account for the suite of available observations under the various proposed hypotheses. Upon comparison of alternative proposals regarding what causal processes may have led to the array of observations as we see them, we conclude that the case fora causal association is weak and strains biological plausibility. Instead, apparent association between formaldehyde inhalation and leukemia in some human studies is better interpreted as due to chance or confounding. PMID:21635189

Information Needs of Cancer Patients and Perception of Impact of the Disease, of Self-Efficacy, and Locus of Control.

PubMed

Keinki, C; Seilacher, E; Ebel, M; Ruetters, D; Kessler, I; Stellamanns, J; Rudolph, I; Huebner, J

2016-09-01

The aim of our study was to investigate the relationship between information needs and cancer patients' perceptions of the impact of the disease, self-efficacy, and locus of control. Using a standardized questionnaire, we obtained data from patients who attended a series of lectures. The questionnaire included questions on their information needs, sources of information, satisfaction with information, and short questionnaires on self-efficacy, perception of the disease, and locus of control of reinforcement. Data was obtained from 185 patients. Our results showed that the sources of information that were most often used were physicians (84 %), print media (68 %), and the Internet (59 %); online fora (7.5 %), non-medical practitioners (9.7 %), and telephone-based counseling (8.6 %) were only used by a minority. Patients with a high perception of their own control over the disease more often used any source of information available to them and were more often interested in acquiring additional information. Higher self-efficacy was significantly associated with the need for information on all topics. Patients with a higher external locus of control significantly more often used sources of information and had significantly more need for additional information. By contrast, there were no associations with an internal locus of control. Neither external nor internal locus of control showed any associations with satisfaction with information. Information needs seem to be higher in patients with a high external locus of control and low self-efficacy. Physicians, other professionals, and institutions that provide information may take these relationships into consideration for tailoring their services to patients.

Marine Mammal Impacts in Exploited Ecosystems: Would Large Scale Culling Benefit Fisheries?

PubMed Central

Morissette, Lyne; Christensen, Villy; Pauly, Daniel

2012-01-01

Competition between marine mammals and fisheries for marine resources—whether real or perceived—has become a major issue for several countries and in international fora. We examined trophic interactions between marine mammals and fisheries based on a resource overlap index, using seven Ecopath models including marine mammal groups. On a global scale, most food consumed by marine mammals consisted of prey types that were not the main target of fisheries. For each ecosystem, the primary production required (PPR) to sustain marine mammals was less than half the PPR to sustain fisheries catches. We also developed an index representing the mean trophic level of marine mammal's consumption (TLQ) and compared it with the mean trophic level of fisheries' catches (TLC). Our results showed that overall TLQ was lower than TLC (2.88 versus 3.42). As fisheries increasingly exploit lower-trophic level species, the competition with marine mammals may become more important. We used mixed trophic impact analysis to evaluate indirect trophic effects of marine mammals, and in some cases found beneficial effects on some prey. Finally, we assessed the change in the trophic structure of an ecosystem after a simulated extirpation of marine mammal populations. We found that this lead to alterations in the structure of the ecosystems, and that there was no clear and direct relationship between marine mammals' predation and the potential catch by fisheries. Indeed, total biomass, with no marine mammals in the ecosystem, generally remained surprisingly similar, or even decreased for some species. PMID:22970153

Trial protocol: a clustered, randomised, longitudinal, type 2 translational trial of alcohol consumption and alcohol-related harm among adolescents in Australia.

PubMed

Rowland, B; Abraham, C; Carter, R; Abimanyi-Ochom, J; Kelly, A B; Kremer, P; Williams, J W; Smith, R; Hall, J K; Wagner, D; Renner, H; Hosseini, T; Osborn, A; Mohebbi, M; Toumbourou, J W

2018-04-27

This cluster randomised control trial is designed to evaluate whether the Communities That Care intervention (CTC) is effective in reducing the proportion of secondary school age adolescents who use alcohol before the Australian legal purchasing age of 18 years. Secondary outcomes are other substance use and antisocial behaviours. Long term economic benefits of reduced alcohol use by adolescents for the community will also be assessed. Fourteen communities and 14 other non-contiguous communities will be matched on socioeconomic status (SES), location, and size. One of each pair will be randomly allocated to the intervention in three Australian states (Victoria, Queensland and Western Australia). A longitudinal survey will recruit grade 8 and 10 students (M = 15 years old, N = 3500) in 2017 and conduct follow-up surveys in 2019 and 2021 (M = 19 years old). Municipal youth populations will also be monitored for trends in alcohol-harms using hospital and police administrative data. Community-led interventions that systematically and strategically implement evidence-based programs have been shown to be effective in producing population-level behaviour change, including reduced alcohol and drug use. We expect that the study will be associated with significant effects on alcohol use amongst adolescents because interventions adopted within communities will be based on evidence-based practices and target specific problems identified from surveys conducted within each community. The trial was retrospectively registered in September, 2017 ( ACTRN12616001276448 ), as communities were selected prior to trial registration; however, participants were recruited after registration. Findings will be disseminated in peer-review journals and community fora.

National policy-makers speak out: are researchers giving them what they need?

PubMed Central

Hyder, Adnan A; Corluka, Adrijana; Winch, Peter J; El-Shinnawy, Azza; Ghassany, Harith; Malekafzali, Hossein; Lim, Meng-Kin; Mfutso-Bengo, Joseph; Segura, Elsa; Ghaffar, Abdul

2011-01-01

The objective of this empirical study was to understand the perspectives and attitudes of policy-makers towards the use and impact of research in the health sector in low- and middle-income countries. The study used data from 83 semi-structured, in-depth interviews conducted with purposively selected policy-makers at the national level in Argentina, Egypt, Iran, Malawi, Oman and Singapore. The interviews were structured around an interview guide developed based on existing literature and in consultation with all six country investigators. Transcripts were processed using a thematic-analysis approach. Policy-makers interviewed for this study were unequivocal in their support for health research and the high value they attribute to it. However, they stated that there were structural and informal barriers to research contributing to policy processes, to the contribution research makes to knowledge generally, and to the use of research in health decision-making specifically. Major findings regarding barriers to evidence-based policy-making included poor communication and dissemination, lack of technical capacity in policy processes, as well as the influence of the political context. Policy-makers had a variable understanding of economic analysis, equity and burden of disease measures, and were vague in terms of their use in national decisions. Policy-maker recommendations regarding strategies for facilitating the uptake of research into policy included improving the technical capacity of policy-makers, better packaging of research results, use of social networks, and establishment of fora and clearinghouse functions to help assist in evidence-based policy-making. PMID:20547652

Expectancy Learning from Probabilistic Input by Infants

PubMed Central

Romberg, Alexa R.; Saffran, Jenny R.

2013-01-01

Across the first few years of life, infants readily extract many kinds of regularities from their environment, and this ability is thought to be central to development in a number of domains. Numerous studies have documented infants’ ability to recognize deterministic sequential patterns. However, little is known about the processes infants use to build and update representations of structure in time, and how infants represent patterns that are not completely predictable. The present study investigated how infants’ expectations fora simple structure develope over time, and how infants update their representations with new information. We measured 12-month-old infants’ anticipatory eye movements to targets that appeared in one of two possible locations. During the initial phase of the experiment, infants either saw targets that appeared consistently in the same location (Deterministic condition) or probabilistically in either location, with one side more frequent than the other (Probabilistic condition). After this initial divergent experience, both groups saw the same sequence of trials for the rest of the experiment. The results show that infants readily learn from both deterministic and probabilistic input, with infants in both conditions reliably predicting the most likely target location by the end of the experiment. Local context had a large influence on behavior: infants adjusted their predictions to reflect changes in the target location on the previous trial. This flexibility was particularly evident in infants with more variable prior experience (the Probabilistic condition). The results provide some of the first data showing how infants learn in real time. PMID:23439947

A review of health promotion funding for older adults in Europe: a cross-country comparison.

PubMed

Arsenijevic, Jelena; Groot, Wim; Tambor, Marzena; Golinowska, Stanislawa; Sowada, Christoph; Pavlova, Milena

2016-09-05

Health promotion interventions for older adults are important as they can decrease the onset and evolution of diseases and thus can reduce the medical costs related to those diseases. However, there is no comparative evidence on how those interventions are funded in European countries. The aim of this study is to explore the funding of health promotion interventions in general and health promotion interventions for older adults in particular in European countries. We use desk research to identify relevant sources of information such as official national documents, international databases and scientific articles. Fora descriptive overview on how health promotion is funded, we focus on three dimensions: who is funding health promotion, what are the contribution mechanisms and who are the collecting agents. In addition to general information on funding of health promotion, we explore how programs on health promotion for older population groups are funded. There is a great diversity in funding of health promotion in European countries. Although public sources (tax and social health insurance revenues) are still most often used, other mechanisms of funding such as private donations or European funds are also common. Furthermore, there is no clear pattern in the funding of health promotion for different population groups. This is of particular importance for health promotion for older adults where information is limited across European countries. This study provides an overview of funding of health promotion interventions in European countries. The main obstacles for funding health promotion interventions are lack of information and the fragmentation in the funding of health promotion interventions for older adults.

Marine mammal impacts in exploited ecosystems: would large scale culling benefit fisheries?

PubMed

Morissette, Lyne; Christensen, Villy; Pauly, Daniel

2012-01-01

Competition between marine mammals and fisheries for marine resources-whether real or perceived-has become a major issue for several countries and in international fora. We examined trophic interactions between marine mammals and fisheries based on a resource overlap index, using seven Ecopath models including marine mammal groups. On a global scale, most food consumed by marine mammals consisted of prey types that were not the main target of fisheries. For each ecosystem, the primary production required (PPR) to sustain marine mammals was less than half the PPR to sustain fisheries catches. We also developed an index representing the mean trophic level of marine mammal's consumption (TL(Q)) and compared it with the mean trophic level of fisheries' catches (TL(C)). Our results showed that overall TL(Q) was lower than TL(C) (2.88 versus 3.42). As fisheries increasingly exploit lower-trophic level species, the competition with marine mammals may become more important. We used mixed trophic impact analysis to evaluate indirect trophic effects of marine mammals, and in some cases found beneficial effects on some prey. Finally, we assessed the change in the trophic structure of an ecosystem after a simulated extirpation of marine mammal populations. We found that this lead to alterations in the structure of the ecosystems, and that there was no clear and direct relationship between marine mammals' predation and the potential catch by fisheries. Indeed, total biomass, with no marine mammals in the ecosystem, generally remained surprisingly similar, or even decreased for some species.

Retail Survey of Brazilian Milk and Minas Frescal Cheese and a Contaminated Dairy Plant To Establish Prevalence, Relatedness, and Sources of Listeria monocytogenes Isolates▿

PubMed Central

Brito, J. Renaldi F.; Santos, Emilia M. P.; Arcuri, Edna F.; Lange, Carla C.; Brito, Maria A. V. P.; Souza, Guilherme N.; Cerqueira, Mônica M. P. O.; Beltran, J. Marcela Soto; Call, Jeffrey E.; Liu, Yanhong; Porto-Fett, Anna C. S.; Luchansky, John B.

2008-01-01

A study was designed to recover Listeria monocytogenes from pasteurized milk and Minas frescal cheese (MFC) sampled at retail establishments (REs) and to identify the contamination source(s) of these products in the corresponding dairy processing plant. Fifty milk samples (9 brands) and 55 MFC samples (10 brands) were tested from REs located in Juiz de Fora, Minas Gerais, Brazil. All milk samples and 45 samples from 9 of 10 MFC brands tested negative for L. monocytogenes; however, “brand F” of MFC obtained from REs 119 and 159 tested positive. Thus, the farm/plant that produced brand F MFC was sampled; all samples from the milking parlor tested negative for L. monocytogenes, whereas several sites within the processing plant and the MFC samples tested positive. All 344 isolates recovered from retail MFC, plant F MFC, and plant F environmental samples were serotype 1/2a and displayed the same AscI or ApaI fingerprints. Since these results established that the storage coolers served as the contamination source of the MFC, plant F was closed so that corrective renovations could be made. Following renovation, samples from sites that previously tested positive for the pathogen were collected from the processing environment and from MFC on multiple visits; all tested negative for L. monocytogenes. In addition, on subsequent visits to REs 159 and 119, all MFC samples tested negative for the pathogen. Studies are ongoing to quantify the prevalence, levels, and types of L. monocytogenes in MFC and associated processing plants to lessen the likelihood of listeriosis in Brazil. PMID:18502929

Factors that impact access to ongoing health care for First Nation children with a chronic condition.

PubMed

Coombes, Julieann; Hunter, Kate; Mackean, Tamara; Holland, Andrew J A; Sullivan, Elizabeth; Ivers, Rebecca

2018-06-14

Access to multidisciplinary health care services for First Nation children with a chronic condition is critical for the child's health and well-being, but disparities and inequality in health care systems have been almost impossible to eradicate for First Nation people globally. The objective of this review is to identify the factors that impact access and ongoing care for First Nation children globally with a chronic condition. An extensive systematic search was conducted of nine electronic databases to identify primary studies that explored factors affecting access to ongoing services for First Nation children with a chronic disease or injury. Due to the heterogeneity of included studies the Mixed Method Appraisal Tool (MMAT) was used to assess study quality. A total of six studies from Australia, New Zealand and Canada were identified and included in this review. Four studies applied qualitative approaches using in-depth semi structured interviews, focus groups and community fora. Two of the six studies used quantitative approaches. Facilitators included the utilisation of First Nation liaison workers or First Nation Health workers. Key barriers that emerged included lack of culturally appropriate health care, distance, language and cultural barriers, racism, the lack of incorporation of First Nation workers in services, financial difficulties and transport issues. There are few studies that have identified positive factors that facilitate access to health care for First Nation children. There is an urgent need to develop programs and processes to facilitate access to appropriate health care that are inclusive of the cultural needs of First Nation children.

Detection of Antibiotic Resistance Determinants and their Transmissibility among Clinically-isolated Carbapenem-resistant Escherichia coli from South India.

PubMed

Mahalingam, Niranjana; Manivannan, Bhavani; Khamari, Balaram; Siddaramappa, Shivakumara; Adak, Sudeshna; Bulagonda, Eswarappa Pradeep

2018-05-08

The aim of this study was to analyze the prevalence of CTX-M, TEM, SHV, VIM, NDM and OXA genes in carbapenemase-producing E. coli and their transmissibility at a tertiary care hospital in south India. Twenty-one carbapenem-resistant E. coli (CRE) were collected from Sri Sathya Sai Institute of Higher Medical Sciences, Prasanthigram, India. Resistance to antibiotics was analyzed by Vitek-2, and identity of the isolates was confirmed by 16S rDNA sequencing. RAPD and ERIC-PCR was performed for molecular typing. Metallo beta-lactamase production was confirmed by double disc synergy test. Presence of the extended spectrum beta lactamases CTX-M, TEM and SHV, and the carbapenemases NDM, VIM and OXA were determined by PCR. Carbapenemase variants were further confirmed by sequencing. Transmissibility of the genes was tested by conjugation. Twelve of the twenty-one (57%) carbapenem-resistant E. coli isolates were community-acquired, indicating the spread of CRE in environmental samples. TEM and NDM-5 were found to be the major beta-lactamases produced by the pathogens. OXA-181 was found in five of the isolates. All the 21 isolates were found to harbor more than one of the tested beta-lactamases, and all the isolates were found to have the capacity to participate in conjugation; fifteen of the transconjugants were found to have acquired the tested beta-lactamases, substantiating their ability to get transferred to other strains of bacteria. Monitoring of community-acquired carbapenem-resistant bacteria is very important as the association of resistance determinants with mobile genetic elements would present a serious clinical challenge. ©2018The Author(s). Published by S. Karger AG, Basel.

Cortical thickness and low insight into symptoms in enduring schizophrenia.

PubMed

Emami, Seema; Guimond, Synthia; Mallar Chakravarty, M; Lepage, Martin

2016-01-01

Poor insight is a common, multidimensional phenomenon in patients with schizophrenia, associated with poorer outcomes and treatment non-adherence. Yet scant research has investigated the neuronal correlates of insight into symptoms (IS), a dimension of insight that may be particularly significant in enduring schizophrenia. Sixty-six patients with enduring schizophrenia (duration >4years) and 33 healthy controls completed MRI scanning and IQ, depression, and anxiety assessments. The Scale to Assess Insight-Expanded (SAI-E) measured insight into patients' four most prominent symptoms and patients were classified into two groups: low IS (0-2; n=33), and high IS (>2; n=33). We evaluated the association between cortical thickness (CT) and insight into symptoms using two methods: (1) a between-patients region-of-interest analysis in the insula, superior temporal gyrus (STG) and frontal lobe; and (2) a whole-brain exploratory regression between patient and controls. Brain regions were segmented using a neuroanatomical atlas and vertex-wise CT analyses were conducted with CIVET, covaried for age and sex. ROI analysis revealed thinner insula cortex in patients with low IS (p<0.05, surviving FDR correction). Patients with low IS also showed significantly thinner right insula, STG, and parahippocampal cortex compared to healthy controls (p<0.05, surviving FDR correction). Regions of observed CT reductions have been hypothesized to subserve self-monitoring, error awareness, and ability to identify hallucinations. Results highlight an important association between right insula abnormalities and impaired IS in schizophrenia. The diverse clinical presentation of patients further suggests an independent relationship between symptomology and insight-related differences in CT that has been previously unexplored in enduring schizophrenia. Copyright © 2015 Elsevier B.V. All rights reserved.

Specific Safety Profile of Bevacizumab in Asian Patients With Advanced NSCLC

PubMed Central

Chen, Zhenguang; Zhong, Beilong; Lun, Xueping; Lai, Yingrong; Bella, Amos Ela; Yang, Weilin; Wu, Jiabin

2015-01-01

Abstract Randomized studies have obtained varying findings regarding the benefits and toxicities of bevacizumab in the treatment of nonsmall cell lung cancer (NSCLC). It is unclear whether the discrepancies among trials are due to ethnic/racial differences. We therefore performed a meta-analysis of all published, randomized, controlled clinical trials involving bevacizumab in patients with NSCLC to assess its effectiveness and safety in Asian and non-Asian populations. Results from the phase II JO19907 trial, the phase III AVAiL and ECOG 4599 trials, and the phase IV SAiL trials were used to calculate the benefits and toxicities of bevacizumab in Asian and non-Asian patients. Combined statistical estimates, including hazard ratios and odds ratios, were calculated using fixed-effects and random-effects models. A total of 4308 patients were evaluated. Combining bevacizumab with different chemotherapy regimens resulted in similar objective response rates, overall survival, and progression-free survival in Asian and non-Asian populations. Disease control rates, however, were only reported in Asian populations. The rates of severe bleeding (relative risk [RR], 2.17; P = 0.02) and thromboembolism (RR, 3.65; P < 0.0001) were significantly higher, while the rate of severe proteinuria was significantly lower (RR, 0.43; P < 0.0001), in non-Asian than in Asian populations. The rates of severe hypertension (P = 0.71) and hemoptysis (P = 0.66) were similar in Asian and non-Asian populations. Bevacizumab combined with chemotherapy for first-line NSCLC treatment showed similar benefits in Asian and non-Asian populations, but had specific safety profiles in each. PMID:26091469

Impacts of radiation management techniques on the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Adakudlu, Muralidhar; Helge Otterå, Odd; Tjiputra, Jerry; Muri, Helene; Grini, Alf; Schulz, Michael

2017-04-01

The effectiveness of various climate engineering techniques in limiting the global warming signal to reasonable levels has been the topic of state-of-the-art research on climate change. Using an Earth system model, we show that these techniques have the potential to bring down the high CO2 concentration climate in RCP8.5 to a moderate climate similar to RCP4.5 in terms of global temperature. Nevertheless, their influence on the regional aspects of atmospheric circulation is not clear. The regional circulation patterns in the atmosphere are largely characterized by the natural variability modes, such as the North Atlantic Oscillation (NAO). In this study, we assess the impacts of three radiation managment techniques, namely, Stratospheric Aerosol Injection (SAI), Marine Sky Brightening (MSB) and Cirrus Cloud Thinning (CCT), on the structure and features of the NAO. The results indicate an east-northeastward shift as well as intensification of the NAO spatial pattern in the global warming scenarios of RCP4.5 and RCP8.5, with the signal being most intense in the latter. The climate engineering forcings when applied to the RCP8.5 case tend to reduce the strength of the NAO with little impact on its position. The CCT case appears to have the maximum effect on the NAO signal. The patterns of cloud radiative forcing, expressed as the difference between net radiative forcing at TOA under average conditions and clear sky conditions, reveal a northeastward shift of the radiative heating in the north Atlantic region. This implies a possible link between the changes in the NAO signal and the cloud radiative forcing.

Do psychosis patients with poor insight show implicit awareness on the emotional stroop task?

PubMed

Wiffen, Benjamin D R; O'Connor, Jennifer A; Russo, Manuela; Falcone, M Aurora; Joseph, Candice; Kolliakou, Anna; Di Forti, Marta; Murray, Robin M; David, Anthony S

2014-01-01

The insight into psychosis can be assessed reliably by clinicians from interviews with patients. However, patients may retain implicit awareness of illness while lacking explicit awareness. In a sample of first-episode psychosis patients, we used a test of processing of mental illness-related and other negative words as a measure of implicit awareness to see how this varied in relation to insight. An emotional-counting Stroop task tested reaction times to words of three types: psychosis-related (e.g. 'crazy'), general negative (e.g. 'cancer') and neutral (e.g. 'oyster'). Data were available from 43 patients and 23 healthy controls. Patients' insight was assessed using the Schedule for the Assessment of Insight (SAI-E). Patients reacted slower than controls to words across all conditions, and both patients and controls reacted slower to salient and negative words than neutral words. There was a near significant interaction between word type and group (Wilks' lambda = 0.53, p = 0.055); patients experienced greater interference from negative rather than psychosis-related words (p = 0.003), and controls experienced greater interference from salient rather than negative words (p = 0.01). Within the patient group, there was a correlation between insight and interference on salient words (r = 0.33, p = 0.05), such that those with less insight experienced less interference on psychosis-related words. Psychosis-related words were less threatening and less self-relevant to psychosis patients with less insight. This suggests that the lack of awareness such patients have of their illness is genuine and more likely to be mediated by lower-level information processing mechanisms than strategies such as conscious, motivated denial. Copyright © 2013 S. Karger AG, Basel.

Photographic Observations of Major Planets and Their Moons During 1961-1990 at the MAO NAS of Ukraine

NASA Astrophysics Data System (ADS)

Yizhakevych, O. M.; Andruk, V. M.; Pakuliak, L. K.

We present the results of photographic observations' processing of Saturn's moons, Uranus, Neptune and their moons on the basis of MAO NAS of Ukraine photographic observational archive. The analysis of the results is given. Observations were obtained using 4 telescopes: Double Long-Focus Astrograph (DLFA, D/F = 400/5500), Zeiss Double Astrograph (DAZ, D/F= 400/3000), Reflector Zeiss-600 (D/F= 600/7500), Wideangle Astrograph, (DWA, D/F= 400/2000). Observations were carried out during 1961 - 1990 (http://gua.db.ukrvo. org). Digitizing of plates has been done by EPSON EXPRESSION 10000XL (EE) flatbed scanner in 16-bit gray color range with resolution 1200dpi.(Andruk et al.: 2005, 2012; Golovnja et al.: 2010;. Protsyuk et al. 2014a, 2014b). The reduction of plates was made using the software developed in MAO NASU in the enhanced LINUX-MIDAS software kit. (Andruk V. et al.: 2016a, 2016b). Tycho2 was used as a reference system. The internal accuracy of the reduction for the first three instruments is ±0.08 - ±0.13 arcsec for both coordinates. For the wide angle astrograph DWA, RMS errors appeared 2 - 2.5 times higher. The total amount of processed plates with images of Saturn's moons is 209 (511 frames), 33 plates contain the images of Uranus and U1,U2,U3,U4 moons, 29 plates have images of Neptune and N1 moon (Yizhakevych et al., 2015, 2016, 2017; Protsyuk et al., 2015). The online comparison of calculated positions of objects with IMCCE ephemeris data was made (http://lnfm1.sai.msu.ru/neb/nss/nssephmf.htm).

Analysis of the Reference Systems of Modern Selenographic Systems

NASA Astrophysics Data System (ADS)

Nefedyev, Yuri; Petrova, Natalia; Andreev, Alexey; Demina, Natalya

2016-07-01

In this work analysis of the reference systems of modern selenographic systems was made. The center of the Moon's mass position relative to its center of figure was determined from the data of "Clementine" and "Kaguya" missions and "ULCN" and "KSC-1162" catalogues. The knowledge of the Moon's center of mass position relative to its center of figure is important for researches of the lunar origin, structure and evolution and in terms of precision solutions circumlunar navigation tasks. At the present this task is the most relevant and demanded for cosmic lunar missions.The expansions by spherical harmonics N=5 degree and order of the lunar function h (λ, β) using the package ASNI USTU were executed. Module of the expansion of the local area to surfaces to full sphere was used. The parameters of cosmic missions are given for comparison (SAI; Bills, Ferrari). The normalized coefficients from expansions for eight sources of hypsometric information are obtained: "Clementine" (N=40), "KSC-1162" (N=5), "Kiev" (N=5), "SAI" (N=10; Chuikova (1975)), "Bills, Ferrari", "Kaguya" (Selena, Japan mission), "ULCN" (The Unified Lunar Control Network 2005). The displacements of the lunar center of figure relative to the lunar center of the mass were defined from equations (Chuikova (1975)): Δ ξ = C_{11} √{3}, Δ η= S_{11} √{3}, Δ ζ = C_{10} √{3}, where ξ is the axis directed towards the Earth, η is equatorial axis directed perpendicularly to ξ , ζ is rotation axis of the Moon, C_{11} , S_{11} , C_{10} are the normalized amplitudes of the harmonics of the first order expansion of the relief. After that we considered: - mathematical models in the form of expansions in spherical functions - methods for estimating the model parameters; - information technology data processing. As a model describing the behavior of the relief on the lunar sphere is used the expansion of the height in a series of spherical harmonics (Sagitov (1979)) in the form of a regression model

Bulge Growth and Quenching Since Z=2.5 in Candels/3D-HST

NASA Technical Reports Server (NTRS)

Lang, Phillip; Wuyts, Stijn; Somerville, Rachel S.; Schreiber, Natascha M. Foerster; Genzel, Reinhard; Bell, Eric F.; Brammer, Gabe; Dekel, Avishai; Faber, Sandra M.; Ferguson, Henry C.;

Second Generation Reusable Launch Vehicle Development and Global Competitiveness of US Space Transportation Industry: Critical Success Factors Assessment

NASA Technical Reports Server (NTRS)

Enyinda, Chris I.

2002-01-01

In response to the unrelenting call in both public and private sectors fora to reduce the high cost associated with space transportation, many innovative partially or fully RLV (Reusable Launch Vehicles) designs (X-34-37) were initiated. This call is directed at all levels of space missions including scientific, military, and commercial and all aspects of the missions such as nonrecurring development, manufacture, launch, and operations. According to Wertz, tbr over thirty years, the cost of space access has remained exceedingly high. The consensus in the popular press is that to decrease the current astronomical cost of access to space, more safer, reliable, and economically viable second generation RLVs (SGRLV) must be developed. Countries such as Brazil, India, Japan, and Israel are now gearing up to enter the global launch market with their own commercial space launch vehicles. NASA and the US space launch industry cannot afford to lag behind. Developing SGRLVs will immeasurably improve the US's space transportation capabilities by helping the US to regain the global commercial space markets while supporting the transportation capabilities of NASA's space missions, Developing the SGRLVs will provide affordable commercial space transportation that will assure the competitiveness of the US commercial space transportation industry in the 21st century. Commercial space launch systems are having difficulty obtaining financing because of the high cost and risk involved. Access to key financial markets is necessary for commercial space ventures. However, public sector programs in the form of tax incentives and credits, as well as loan guarantees are not yet available. The purpose of this paper is to stimulate discussion and assess the critical success factors germane for RLVs development and US global competitiveness.

The ‘who’ and ‘what’ of #diabetes on Twitter

PubMed Central

Beguerisse-Díaz, Mariano; McLennan, Amy K.; Garduño-Hernández, Guillermo; Barahona, Mauricio; Ulijaszek, Stanley J.

2017-01-01

Social media are being increasingly used for health promotion, yet the landscape of users, messages and interactions in such fora is poorly understood. Studies of social media and diabetes have focused mostly on patients, or public agencies addressing it, but have not looked broadly at all of the participants or the diversity of content they contribute. We study Twitter conversations about diabetes through the systematic analysis of 2.5 million tweets collected over 8 months and the interactions between their authors. We address three questions. (1) What themes arise in these tweets? (2) Who are the most influential users? (3) Which type of users contribute to which themes? We answer these questions using a mixed-methods approach, integrating techniques from anthropology, network science and information retrieval such as thematic coding, temporal network analysis and community and topic detection. Diabetes-related tweets fall within broad thematic groups: health information, news, social interaction and commercial. At the same time, humorous messages and references to popular culture appear consistently, more than any other type of tweet. We classify authors according to their temporal ‘hub’ and ‘authority’ scores. Whereas the hub landscape is diffuse and fluid over time, top authorities are highly persistent across time and comprise bloggers, advocacy groups and NGOs related to diabetes, as well as for-profit entities without specific diabetes expertise. Top authorities fall into seven interest communities as derived from their Twitter follower network. Our findings have implications for public health professionals and policy makers who seek to use social media as an engagement tool and to inform policy design. PMID:29942579

The integration of an anatomy massive open online course (MOOC) into a medical anatomy curriculum.

PubMed

Swinnerton, Bronwen J; Morris, Neil P; Hotchkiss, Stephanie; Pickering, James D

2017-01-01

Massive open online courses (MOOCs) are designed as stand-alone courses which can be accessed by any learner around the globe with only an internet-enabled electronic device required. Although much research has focused on the enrolment and demographics of MOOCs, their impact on undergraduate campus-based students is still unclear. This article explores the impact of integrating an anatomy MOOC in to the anatomy curriculum of a year 1 medical degree program at the University of Leeds, United Kingdom. The course did not replace any teaching that was already being delivered, and was used to supplement this teaching to support the students' consolidation and revision. Analysis of student feedback indicates a high level of usage, with evidence to suggest that female learners may have approached the course in a more personalized manner. Although the video based resources and quizzes were greatly appreciated as learning tools, significant evidence suggests the students did not engage, or were inclined to engage, with the discussion fora. Furthermore, a significant majority of students did not want the MOOC to replace the existing teaching they received. Given the feedback provided, this research suggests that although the student population believe there to be value in having access to MOOC material, their role as replacements to campus-based teaching is not supported. Details regarding the enrolment and engagement of the general public with the MOOC during the two runs are also documented, with the suggestion that graduates employed in the healthcare sector were the primary users of the course. Anat Sci Educ 10: 53-67. © 2016 American Association of Anatomists. © 2016 American Association of Anatomists.

Hair analysis for the detection of drug use-is there potential for evasion?

PubMed

Marrinan, Shanna; Roman-Urrestarazu, Andres; Naughton, Declan; Levari, Emerlinda; Collins, John; Chilcott, Robert; Bersani, Giuseppe; Corazza, Ornella

2017-05-01

Hair analysis for illicit substances is widely used to detect chronic drug consumption or abstention from drugs. Testees are increasingly seeking ways to avoid detection by using a variety of untested adulterant products (e.g., shampoos, cleansers) widely sold online. This study aims to investigate adulteration of hair samples and to assess effectiveness of such methods. The literature on hair test evasion was searched for on PubMed or MEDLINE, Psycinfo, and Google Scholar. Given the sparse nature of peer-reviewed data on this subject, results were integrated with a qualitative assessment of online sources, including user-orientated information or commercial websites, drug fora and "chat rooms". Over four million web sources were identified in a Google search by using "beat hair drug test" and the first 86 were monitored on regular basis and considered for further analysis. Attempts to influence hair test results are widespread. Various "shampoos," and "cleansers" among other products, were found for sale, which claim to remove analytes. Often advertised with aggressive marketing strategies, which include discounts, testimonials, and unsupported claims of efficacy. However, these products may pose serious health hazards and are also potentially toxic. In addition, many anecdotal reports suggest that Novel Psychoactive Substances are also consumed as an evasion technique, as these are not easily detectable via standard drug test. Recent changes on Novel Psychoactive Substances legislations such as New Psychoactive Bill in the UK might further challenge the testing process. Further research is needed by way of chemical analysis and trial of the adulterant products sold online and their effects as well as the development of more sophisticated hair testing techniques. Copyright © 2017 John Wiley & Sons, Ltd.

The role of constructed wetlands for biomass production within the water-soil-waste nexus.

PubMed

Avellan, C T; Ardakanian, R; Gremillion, P

2017-05-01

The use of constructed wetlands for water pollution control has a long standing tradition in urban, peri-urban, rural, agricultural and mining environments. The capacity of wetland plants to take up nutrients and to filter organic matter has been widely discussed and presented in diverse fora and published in hundreds of articles. In an ever increasingly complex global world, constructed wetlands not only play a role in providing safe sanitation in decentralized settings, shelter for biodiversity, and cleansing of polluted sites, in addition, they produce biomass that can be harvested and used for the production of fodder and fuel. The United Nations University Institute for Integrated Management of Material Fluxes and of Resources (UNU-FLORES) was established in December 2012 in Dresden, Germany, to assess the trade-offs between and among resources when making sustainable decisions. Against the backdrop of the Water-Energy-Food Nexus, which was introduced as a critical element for the discussions on sustainability at Rio +20, the UNU was mandated to pay critical attention to the interconnections of the underlying resources, namely, water, soil and waste. Biomass for human consumption comes in the form of food for direct use, as fodder for livestock, and as semi-woody biomass for fuelling purposes, be it directly for heating and cooking or for the production of biogas and/or biofuel. Given the universal applicability of constructed wetlands in virtually all settings, from arid to tropical, from relatively high to low nutrient loads, and from a vast variety of pollutants, we postulate that the biomass produced in constructed wetlands can be used more extensively in order to enhance the multi-purpose use of these sites.

A clearing house for diagnostic testing: the solution to ensure access to and use of patented genetic inventions?

PubMed Central

van Zimmeren, Esther; Verbeure, Birgit; Matthijs, Gert; Van Overwalle, Geertrui

2006-01-01

In genetic diagnostics, the emergence of a so-called "patent thicket" is imminent. Such an overlapping set of patent rights may have restrictive effects on further research and development of diagnostic tests, and the provision of clinical diagnostic services. Currently, two models that may facilitate access to and use of patented genetic inventions are attracting much debate in various national and international fora: patent pools and clearing houses. In this article, we explore the concept of clearing houses. Several types of clearing houses are identified. First, we describe and discuss two types that would provide access to information on the patented inventions: the information clearing house and the technology exchange clearing house. Second, three types of clearing houses are analysed that not only offer access to information but also provide an instrument to facilitate the use of the patented inventions: the open access clearing house, the standardized licences clearing house and the royalty collection clearing house. A royalty collection clearing house for genetic diagnostic testing would be the most comprehensive as it would serve several functions: identifying patents and patent claims essential to diagnostic testing, matching licensees with licensors, developing and supplying standardized licences, collecting royalties, monitoring whether users respect licensing conditions, and providing dispute resolution services such as mediation and arbitration. In this way, it might function as an effective model for users to facilitate access to and use of the patented inventions. However, it remains to be seen whether patent holders with a strong patent portfolio will be convinced by the advantages of the royalty collection clearing house and be willing to participate. PMID:16710543