Development of Metrics for Trust in Automation

DTIC Science & Technology

2010-06-01

Systems Literature Review Defence Research and Development Canada Toronto No. CR-2003-096 Ajzen , I ., & Fishbein , M . (1980). Understanding attitudes...theory and research (pp. 261–287). Thousand Oaks, CA: Sage. Moray, N., Inagaki, T., Itoh, M ., 2000 . Adaptive automation, trust, and self-confidence...Assurance Technical Framework document ( 2000 ), the term ‘trust’ is used 352 times, ranging from reference to the trustworthiness of technology, to

NATO Guidelines on Human Engineering Testing and Evaluation

DTIC Science & Technology

2001-05-01

1980s and is known as Manpower, Personnel, and Training Integration (MANPRINT). The objective of this comprehensive management and technical effort is...systems under benign test conditions, using test subjects who are considerably more knowledeable of the system than the eventual users of the system will...Technical Management , Aeronautical Systems Division, Air Force Systems Command. Itoh, Y., Hayashi, Y., Tsukui, L, and Saito, S. (1989). Heart rate

Silicon Quantum Dots for Quantum Information Processing

DTIC Science & Technology

2013-11-01

Thewalt, and K . M. Itoh. Electron spin coherence exceeding seconds in high-purity silicon. Nature Materials, 11(2), 143 (2011). 21 [87] T. Ando, A...120 143 169 REFERENCES [89] M. G. Borselli, R. S. Ross, A. A. Kiselev, E. T. Croke, K . S. Holabird, P. W. Deelman, L. D. Warren, I. Alvarado-Rodriguez...48 3.3.1 4 K Dewar Measurements . . . . . . . . . . . . . . . . . . 48 3.3.2 Dilution

Simulation of Pores Sealing During Homoepitaxy on Si(111) Surface

DTIC Science & Technology

2000-06-23

Yonehara, Jpn. J. Appi. Phys. 37, P2, N11B, 1354 (1998). [5] T. Ito, T. Yasumatsu and A. Hiraki , Appi. Surf Sci. 44, 97 (1990). [6] Y Yasumatsu, T. Ito...H. Nishizawa and A. Hiraki , Appl. Surf Sci. 48/49, 414 (199 1). [7] A. V. Zverev, 1. G. Neizvestny, N. L. Shwartz and Z. Sh. Yanovitskaya, Izv. RAS (Russian) 63, 356 (2000).

The Application of Deterministic Spectral Domain Method to the Analysis of Planar Circuit Discontinuities on Open Substrates

DTIC Science & Technology

1990-08-01

the spectral domain is extended to include the effects of two-dimensional, two-component current flow in planar transmission line discontinuities 6n...PROFESSOR: Tatsuo Itoh A deterministic formulation of the method of moments carried out in the spectral domain is extended to include the effects of...two-dimensional, two- component current flow in planar transmission line discontinuities on open substrates. The method includes the effects of space

Inversion of the 11Bu and 21Ag electronic states of all-trans-1,6-diphenyl-1,3,5-hexatriene in carbon disulfide.

PubMed

Catalán, Javier

2017-10-11

From the analysis of UV/Vis absorption spectra, emission and excitation emission spectra of solutions of all-trans-1,6-diphenyl-1,3,5-hexatriene (DPH) in carbon disulfide (CS 2 ) within a wide range of temperatures, we can conclude that these spectra do not support the inversion of excited electronic states in DPH by an increased polarizability of the solvent as proposed by Kohler and Itoh. The proposal by Kohler and Itoh is widely accepted as an elegant demonstration of the inversion of the 1 1 Bu and 2 1 Ag states in the polyene DPH by a mere increase in the solvent polarizability. The evidence provided in this paper confirms, as has recently been proposed, that a ghost state as the first electronic state, 2 1 Ag, is not necessary to explain the photophysics of DPH. The photophysics of DPH is plausibly explicable with the 1 1 Bu state, which is directly excitable by photonic absorption from the fundamental electronic state of the compound. In this paper, we provide evidence that the UV/Vis spectra of DPH in CS 2 at 77 K are most likely generated from a molecular structure of DPH constrained by solid CS 2 , which is clearly distinct from that present in liquid CS 2 .

Molten Boron Phase-Change Thermal Energy Storage to Augment Solar Thermal Propulsion Systems

DTIC Science & Technology

2011-07-13

Thermodynamic Properties of Transition Metal Borides . I. The Molybdenum-boron system and Elemental Boron," Journal of Physical Chemistry, Vol. 81...February 1977, pp. 318-324. 38Itoh, H., Matsudaira, T., and Naka, S., "Formation Process of Tungsten Borides by Solid State Reaction Between Tungsten...Molybdenum-Boron and Some Properties of The Molybdenum- Borides ," Journal of Metals, September 1952, pp. 983-988. 40Stout, N. D., Mar, R. W., and Boo, W. O

Mechanisms Down-Regulating Sprouty1, a Growth Inhibitor in Prostate Cancer

DTIC Science & Technology

2006-10-01

4139-4147. 6. de Maximy AA, Nakatake Y, Moncada S, Itoh N, Thiery JP, Bellusci S: Cloning and expression pattern of a mouse homologue of Drosophila...22992-22995. 18 10. Gross I, Bassit B, Benezra M, Licht JD: Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras...Pelletier J, Housman DE : Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product. Mol Cell Biol 1995, 15: 1489-1498

Capsule Depolymerase Overexpression Reduces Bacillus anthracis Virulence

DTIC Science & Technology

2010-01-01

protein that autocatalytically forms a heterodimer consisting of 35 kDa and 15 kDa subunits. CapD shares 32 % identity with the Bacillus subtilis GGT and 35...Immun 49, 291–297. Kimura, K., Tran, L. S., Uchida, I. & Itoh, Y. (2004). Characterization of Bacillus subtilis gamma-glutamyltransferase and its...Capsule depolymerase overexpression reduces Bacillus anthracis virulence Angelo Scorpio,3 Donald J. Chabot, William A. Day,4 Timothy A. Hoover and

Technical Reports Prepared Under Contract N00014-76-C-0475.

DTIC Science & Technology

1987-05-29

264 Approximations to Densities in Geometric H. Solomon 10/27/78 Probability M.A. Stephens 3. Technical Relort No. Title Author Date 265 Sequential ...Certain Multivariate S. Iyengar 8/12/82 Normal Probabilities 323 EDF Statistics for Testing for the Gamma M.A. Stephens 8/13/82 Distribution with...20-85 Nets 360 Random Sequential Coding By Hamming Distance Yoshiaki Itoh 07-11-85 Herbert Solomon 361 Transforming Censored Samples And Testing Fit

Mechanisms Down-Regulating Sprouty1, a Growth Inhibitor in Prostate Cancer

DTIC Science & Technology

2007-10-01

Development 1999, 126: 4139-4147. 6. de Maximy AA, Nakatake Y, Moncada S, Itoh N, Thiery JP, Bellusci S: Cloning and expression pattern of a mouse...J Biol Chem 2004, 279: 22992-22995. 10. Gross I, Bassit B, Benezra M, Licht JD: Mammalian sprouty proteins inhibit cell growth and differentiation...Unincorporated [γ-32P] dATP were removed by purifying the probes using a G-25 ( Fine ) Sephadex Quick spin columns (Roche). The EMSAs were carried

The Role of Capase-8 in Breast Carcinoma Cells

DTIC Science & Technology

2006-04-01

and exposed to film. pcDNA3 or pcDNA3-huSNARK-transfected 293T cell extracts (100 #g of protein) were used to determine the phosphorylation of the...proteins (Itoh and Nagata, 1993; Boldin et al, 1995; Chinnaiyan et al, 1995; Siegel et al, 2000). Additional interactions mediated through the N...lanes 5–7) fractions were separated from total cellular membrane extract (lane 1). Following fractionation, association of FADD and caspase-8 with

Point-Source and Area-Wide Field Studies of Pyriproxyfen Autodissemination Against Urban Container-Inhabiting Mosquitoes

DTIC Science & Technology

2014-04-05

trials by Itoh (1994) and subsequently confirmed by Chism and Apperson (2003), Devine et al. (2009) demonstrated in field experiments in Peru that...105 ha in area (Fig. 2), whereas, the control site was in Union Beach , NJ (40.2650 lat., - 74.71026 long.) and spanned 181 ha. Both the treatment and...people/km2) than Union Beach (1384.7 people/km2). We initially intended to assess pyriproxyfen-based area-wide autodissemination by treating 25% of an

A Study of Microwave and Millimeter-Wave Quasi-Optical Planar Mixers.

DTIC Science & Technology

1983-08-31

reasons of symmetry a mode is not excited at all, N goes to infinity and the series impedance at the primary vanishes. Determining the impedance...taken from Araki and Itoh (1]. The primary aim of their work was to calculate the resonanc frequency of a -, circular microstrip patch antenna. They...T11 ALLEVIATE THIS# A TRAO IS PLACED TO SIIUNTITUTE * THE SMALL-ARGUNENT APPftVINATIfI% To THE FUCTION 0WHeW * ARP.I’PRIATE. THE FPLLfljI IF STATENENT

New Methodology for First Principle Calculations of Electrical Levels for Radiation Induced Defects in Silicates

DTIC Science & Technology

2005-02-22

1993). 72 U. Itoh, Y. Toyoshima, H . Onuki , N. Washida, and T. Ibuki, J. Chem. Phys. 85, 4867 (1986). 73 M. J. Field, P. A. Bash, and M. Karplus, J...the following publi- cations: 1. V. B. Sulimov, P. V. Sushko, A. H . Edwards, A. L. Shluger, and A. M. Stoneham, ”Asymmetry and log-range character of...lattice deformation by neu- tral oxygen vacancy in alpha-quartz”, Physical Re- view B, 66, p. 024108, (2002). 2. A. H . Edwards, P. V. Sushko, A. L

Non-invertible transformations of differential-difference equations

NASA Astrophysics Data System (ADS)

Garifullin, R. N.; Yamilov, R. I.; Levi, D.

2016-09-01

We discuss aspects of the theory of non-invertible transformations of differential-difference equations and, in particular, the notion of Miura type transformation. We introduce the concept of non-Miura type linearizable transformation and we present techniques that allow one to construct simple linearizable transformations and might help one to solve classification problems. This theory is illustrated by the example of a new integrable differential-difference equation depending on five lattice points, interesting from the viewpoint of the non-invertible transformation, which relate it to an Itoh-Narita-Bogoyavlensky equation.

Evolution of ribosomal proteins in Enterobacteriaceae.

PubMed Central

Hori, H; Osawa, S

1978-01-01

The evolution of ribosomal proteins of about 70 bacterial strains belonging to the family Enterobacteriaceae has been studied by use of previously reported data (S. Osawa, T. Itoh, and E. Otaka, J. Bacteriol. 107:168-178, 1971) and those obtained in this paper. The proximity of the bacteria was quantified by co-chromatographing the differentially labeled ribosomal proteins from two strains on a column of carboxymethyl cellulose in various combinations. The were then classified into 12 groups (=species?) according to their ribosomal protein compositions and were placed in a phylogenic tree. PMID:346556

Upper-Bounds on Qubit Coherence Set by Master Clock Instabilities

DTIC Science & Technology

2016-01-10

PhysRevLett.95.060502 [3] Olmschenk S, Younge K C, Moehring D L, Matsukevich D N , Maunz P and Monroe C 2007 Phys. Rev. A 76 052314 [4] Soare A, Ball H...Sekiguchi T, Itoh K M, Jamieson D N , McCallum J C, Dzurak A S and Morello A 2014 Nature Nanotechnology 9 986–991 [9] Brown K R, Wilson A C, Colombe Y...Cleland A and Martinis J M 2014 Phys. Rev. Lett. 112(24) 240504 [11] Harty T P, Allcock D, Ballance C J, Guidoni L, Janacek H A, Linke N M, Stacey D N

Spatiotemporal distribution of interplate slip following the 2003 Tokachi-oki earthquake deduced from ocean bottom pressure gauges and onland GNSS data

NASA Astrophysics Data System (ADS)

Itoh, Y.; Nishimura, T.; Ariyoshi, K.; Matsumoto, H.

2017-12-01

The 2003 Tokachi-oki earthquake (Mw 8.0) is an interplate earthquake along the Kurile trench. Its co- and post-seismic deformation has been observed by onland GNSS [e.g., Miyazaki et al. 2004] and modeled with afterslip and/or viscoelastic relaxation [e.g., Itoh and Nishimura 2016]. In the offshore region, two ocean bottom pressure gauges (OBPs) are operated by JAMSTEC since July 1999 [Hirata et al. 2002] and they have continuously observed the pre-, co- and post-seismic pressure change of the 2003 event [Baba et al. 2006]. The observed pressure change can be interpreted as vertical displacement, and the resolution of slip beneath the seafloor far from the land was improved by incorporating these pressure data into onland GNSS data [Baba et al. 2006]. However, no previous studies used postseismic pressure data for several years to estimate an interplate slip. Because, in this region, an M8 class event similar to the 2003 event has occurred in 1952, it is important to clarify a healing process of an interplate coupling which may lead to a next M8 class event in terms of the earthquake cycle. Itoh and Nishimura [2017, JpGU-AGU Joint Meeting] estimated it but used only onland GNSS data. In this study, we use both onland GNSS and OBP data. For OBP data analysis, we first removed the tidal component using BAYTAP08 [Tamura et al. 1991; Tamura and Agnew 2008]. Next, we corrected the temporal fluctuation of data correlating with temperature [Baba et al. 2006]. We estimated the linear trend before the 2003 event using the corrected time series from 2002 Jan. 1 to 2003 Sep. 1 and remove the estimated trend from the data after the 2003 event. Here, we assumed a non-linear drift could be ignored. Finally, we down-sampled the remained time series with an interval of 1 month. For the onland GNSS data, we used the same data set of Itoh and Nishimura [2017, JpGU-AGU Joint Meeting]. We constructed the model consisting of coseismic slip of the 2003 and M6-7 events in the postseismic

Book review: Modern Plasma Physics, Vol. I: Physical Kinetics of Turbulent Plasmas, by Patrick H. Diamond, Sanae-I. Itoh and Kimitaka Itoh, Cambridge University Press, Cambridge (UK), 2010, IX, 417 p., ISBN 978-0-521-86920-1 (Hardback)

NASA Astrophysics Data System (ADS)

Somov, B. V.

If you want to learn not only the most fundamental things about the physics of turbulent plasmas but also the current state of the problem including the most recent results in theoretical and experimental investigations - and certainly many physicists and astrophysicists do - this series of three excellent monographs is just for you. The first volume "Physical Kinetics of Turbulent Plasmas" develops the kinetic theory of turbulence through a focus on quasi-particle models and dynamics. It discusses the concepts and theoretical methods for describing weak and strong fluid and phase space turbulence in plasma systems far from equilibrium. The core material includes fluctuation theory, self-similar cascades and transport, mean field theory, resonance broadening and nonlinear wave-particle interaction, wave-wave interaction and wave turbulence, strong turbulence theory and renormalization. The book gives readers a deep understanding of the fields under consideration and builds a foundation for future applications to multi-scale processes of self-organization in tokamaks and other confined plasmas. In spite of a short pedagogical introduction, the book is addressed mainly to well prepared readers with a serious background in plasma physics, to researchers and advanced graduate students in nonlinear plasma physics, controlled fusions and related fields such as cosmic plasma physics

Self-dual geometry of generalized Hermitian surfaces

NASA Astrophysics Data System (ADS)

Arsen'eva, O. E.; Kirichenko, V. F.

1998-02-01

Several results on the geometry of conformally semiflat Hermitian surfaces of both classical and hyperbolic types (generalized Hermitian surfaces) are obtained. Some of these results are generalizations and clarifications of already known results in this direction due to Koda, Itoh, and other authors. They reveal some unexpected beautiful connections between such classical characteristics of conformally semiflat (generalized) Hermitian surfaces as the Einstein property, the constancy of the holomorphic sectional curvature, and so on. A complete classification of compact self-dual Hermitian RK-surfaces that are at the same time generalized Hopf manifolds is obtained. This provides a complete solution of the Chen problem in this class of Hermitian surfaces.

The exponential parameterization of the neutrino mixing matrix as an SU(3) group element and an account for new experimental data

NASA Astrophysics Data System (ADS)

Zhukovsky, K. V.

2017-09-01

The exponential form of the Pontecorvo-Maki-Nakagawa-Sakata mixing matrix for neutrinos is considered in the context of the fundamental representation of the SU(3) group. The logarithm of the mixing matrix is obtained. Based on the most recent experimental data on neutrino mixing, the exact values of the entries of the exponential matrix are calculated. The exact values for its real and imaginary parts are determined, respectively, in charge of the mixing without CP violation and of the pure CP violation effect. The hypothesis of complementarity for quarks and neutrinos is confirmed. The factorization of the exponential mixing matrix, which allows the separation of the mixing and of the CP violation itself in the form of the product of rotations around the real and imaginary axes, is demonstrated.

Crystal Structures of Copper-depleted and Copper-bound Fungal Pro-tyrosinase

PubMed Central

Fujieda, Nobutaka; Yabuta, Shintaro; Ikeda, Takuya; Oyama, Takuji; Muraki, Norifumi; Kurisu, Genji; Itoh, Shinobu

2013-01-01

Tyrosinase, a dinuclear copper monooxygenase/oxidase, plays a crucial role in the melanin pigment biosynthesis. The structure and functions of tyrosinase have so far been studied extensively, but the post-translational maturation process from the pro-form to the active form has been less explored. In this study, we provide the crystal structures of Aspergillus oryzae full-length pro-tyrosinase in the holo- and the apo-forms at 1.39 and 2.05 Å resolution, respectively, revealing that Phe513 on the C-terminal domain is accommodated in the substrate-binding site as a substrate analog to protect the dicopper active site from substrate access (proteolytic cleavage of the C-terminal domain or deformation of the C-terminal domain by acid treatment transforms the pro-tyrosinase to the active enzyme (Fujieda, N., Murata, M., Yabuta, S., Ikeda, T., Shimokawa, C., Nakamura, Y., Hata, Y., and Itoh, S. (2012) ChemBioChem. 13, 193–201 and Fujieda, N., Murata, M., Yabuta, S., Ikeda, T., Shimokawa, C., Nakamura, Y., Hata, Yl, and Itoh, S. (2013) J. Biol. Inorg. Chem. 18, 19–26). Detailed crystallographic analysis and structure-based mutational studies have shown that the copper incorporation into the active site is governed by three cysteines as follows: Cys92, which is covalently bound to His94 via an unusual thioether linkage in the holo-form, and Cys522 and Cys525 of the CXXC motif located on the C-terminal domain. Molecular mechanisms of the maturation processes of fungal tyrosinase involving the accommodation of the dinuclear copper unit, the post-translational His-Cys thioether cross-linkage formation, and the proteolytic C-terminal cleavage to produce the active tyrosinase have been discussed on the basis of the detailed structural information. PMID:23749993

From H I to Stars: H I Depletion in Starbursts and Star-forming Galaxies in the ALFALFA Hα Survey

NASA Astrophysics Data System (ADS)

Jaskot, A. E.; Oey, M. S.; Salzer, J. J.; Van Sistine, A.; Bell, E. F.; Haynes, M. P.

2015-07-01

H i in galaxies traces the fuel for future star formation and reveals the effects of feedback on neutral gas. Using a statistically uniform, H i-selected sample of 565 galaxies from the Arecibo Legacy Fast ALFA (ALFALFA) Hα survey, we explore H i properties as a function of star formation activity. ALFALFA Hα provides R-band and Hα imaging for a volume-limited subset of the 21 cm ALFALFA survey. We identify eight starbursts based on Hα equivalent width and six with enhanced star formation relative to the main sequence. Both starbursts and non-starbursts have similar H i-to-stellar mass ratios ({M}{{H} {{I}}}/{M}*), which suggests that feedback is not depleting the starbursts’ H i. Consequently, the starbursts do have shorter H i depletion times ({t}{dep}), implying more efficient H i-to-H2 conversion. While major mergers likely drive this enhanced efficiency in some starbursts, the lowest-mass starbursts may experience periodic bursts, consistent with enhanced scatter in {t}{dep} at low {M}*. Two starbursts appear to be pre-coalescence mergers; their elevated {M}{{H} {{I}}}/{M}* suggest that H i-to-H2 conversion is still ongoing at this stage. By comparing with the GASS sample, we find that {t}{dep} anticorrelates with stellar surface density for disks, while spheroids show no such trend. Among early-type galaxies, {t}{dep} does not correlate with bulge-to-disk ratio; instead, the gas distribution may determine the star formation efficiency. Finally, the weak connection between galaxies’ specific star formation rates and {M}{{H} {{I}}}/{M}* contrasts with the well-known correlation between {M}{{H} {{I}}}/{M}* and color. We show that dust extinction can explain the H i-color trend, which may arise from the relationship between {M}*, {M}{{H} {{I}}}, and metallicity.

Theoretical transport modeling of Ohmic cold pulse experiments

NASA Astrophysics Data System (ADS)

Kinsey, J. E.; Waltz, R. E.; St. John, H. E.

1998-11-01

The response of several theory-based transport models in Ohmically heated tokamak discharges to rapid edge cooling due to trace impurity injection is studied. Results are presented for the Institute for Fusion Studies—Princeton Plasma Physics Laboratory (IFS/PPPL), gyro-Landau-fluid (GLF23), Multi-mode (MM), and the Itoh-Itoh-Fukuyama (IIF) transport models with an emphasis on results from the Texas Experimental Tokamak (TEXT) [K. W. Gentle, Nucl. Technol./Fusion 1, 479 (1981)]. It is found that critical gradient models containing a strong ion and electron temperature ratio dependence can exhibit behavior that is qualitatively consistent with experimental observation while depending solely on local parameters. The IFS/PPPL model yields the strongest response and demonstrates both rapid radial pulse propagation and a noticeable increase in the central electron temperature following a cold edge temperature pulse (amplitude reversal). Furthermore, the amplitude reversal effect is predicted to diminish with increasing electron density and auxiliary heating in agreement with experimental data. An Ohmic pulse heating effect due to rearrangement of the current profile is shown to contribute to the rise in the core electron temperature in TEXT, but not in the Joint European Tokamak (JET) [A. Tanga and the JET Team, in Plasma Physics and Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 65] and the Tokamak Fusion Test Reactor (TFTR) [R. J. Hawryluk, V. Arunsalam, M. G. Bell et al., in Plasma Physics and Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. 1, p. 51]. While this phenomenon is not necessarily a unique signature of a critical gradient, there is sufficient evidence suggesting that the apparent plasma response to edge cooling may not require any underlying nonlocal mechanism and may be explained within the context of the intrinsic properties of electrostatic drift

Self-dual geometry of generalized Hermitian surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arsen'eva, O E; Kirichenko, V F

Several results on the geometry of conformally semiflat Hermitian surfaces of both classical and hyperbolic types (generalized Hermitian surfaces) are obtained. Some of these results are generalizations and clarifications of already known results in this direction due to Koda, Itoh, and other authors. They reveal some unexpected beautiful connections between such classical characteristics of conformally semiflat (generalized) Hermitian surfaces as the Einstein property, the constancy of the holomorphic sectional curvature, and so on. A complete classification of compact self-dual Hermitian RK-surfaces that are at the same time generalized Hopf manifolds is obtained. This provides a complete solution of the Chenmore » problem in this class of Hermitian surfaces.« less

Electron screening and its effects on big-bang nucleosynthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang Biao; Bertulani, C. A.; Balantekin, A. B.

We study the effects of electron screening on nuclear reaction rates occurring during the big-bang nucleosynthesis epoch. The sensitivity of the predicted elemental abundances on electron screening is studied in detail. It is shown that electron screening does not produce noticeable results in the abundances unless the traditional Debye-Hueckel model for the treatment of electron screening in stellar environments is enhanced by several orders of magnitude. This work rules out electron screening as a relevant ingredient to big-bang nucleosynthesis, confirming a previous study [see Itoh et al., Astrophys. J. 488, 507 (1997)] and ruling out exotic possibilities for the treatmentmore » of screening beyond the mean-field theoretical approach.« less

Minimal modification of tri-bimaximal neutrino mixing and leptonic CP violation

NASA Astrophysics Data System (ADS)

Kang, Sin Kyu

2017-12-01

We confront possible forms of the minimal modification of the tri-bimaximal (TBM) neutrino mixing matrix proposed by Kang and Kim (Phys. Rev. D 90, 077301 (2014)) with the latest global fit to neutrino data. One form among them is singled out by the current experimental results at 1σ confidence level (C.L.) The minimal modification of the TBM mixing matrix makes possible the prediction of Dirac-type CP phase in the Pontecorbo-Maki-Nakagawa-Sakata neutrino mixing matrix in terms of two neutrino mixing angles. By carrying out a numerical analysis based on the latest experimental results for neutrino mixing angles, we are able to present new results on the prediction of the Dirac-type CP phase. We also compare our results on CP violation with those from the current global fit at 1 σ C.L.

Antibiotics from Pseudomonas reptilivora II. Isolation, Purification, and Properties1

PubMed Central

Del Rio, Luís A.; Gorgé, J. López; Olivares, J.; Mayor, F.

1972-01-01

Under well-established culture conditions, Pseudomonas reptilivora produced several antibiotics that have been purified by solvent extraction, chromatography in Sephadex G-25, electrophoresis, and paper chromatography in different solvent systems. Activity has been monitored at the different steps of isolation and purification by measurement of the inhibition of the growth of Staphylococcus aureus by the cylinder-plate method, as well as by bioautography of chromatograms and electropherograms. Three antibiotics have been isolated and named A, B1, and B2. The B1 and B2 activities were studied in greater detail than A. The B1 substance was crystallized, and its chemical properties were found to coincide with those of YC 73 or fluopsin C described by Egawa et al. and Itoh et al., respectively. Images PMID:4790558

Glassy and Metastable Crystalline BaTi2O5 by Containerless Processing

NASA Astrophysics Data System (ADS)

Yoda, Shinichi; Kentei Yu, Yu; Kumar, Vijaya; Kameko, Masashi

metastable a-and b-BaTi2 O5 are constructed with non-centrosymmetric geometry TiO5 polyhedra, which provides higher potential for yielding high dielectric constants, pyroelectric and nonlinear op-tical properties than that of normal 4-or 6-coordinate Ti-O polyhedra. In addition, all lanthanide elements can be doped into the unusual glassy BaTi2 O5 structure to open up new possibilities for creating new bulk glasses, metastable phases and nano-crystalline ceramics with peculiar electronic and optical properties, such as giant permittivity and strong upconversion luminescence. References [1] Y. Akishige, K. Fukano, and H. Shigematsu, Jpn. J. Appl. Phys. p2, 42, L946 (2003). [2] J. Yu, Y. Arai, T. Masaki, T. Ishikawa, S. Yoda, S. Kohara, H. Taniguchi, M. Itoh, and Y. Kuroiwa, Chem. Matter. 18 p.2169 (2006) [3] J. Yu, S. Kohara, S. Nozawa, K. Itoh, S. Miyoshi, Y. Arai, A. Masuno, H. Taniguchi, M. Itoh, M. Takata, T. Fukunaga, S. Koshihara, Y. Kuroiwa, and S. Yoda, Chem. Matter. 21, p259 (2009).

Search for sterile neutrinos mixing with muon neutrinos in MINOS

DOE PAGES

Adamson, P.; Anghel, I.; Aurisano, A.; ...

2016-10-07

Here, we report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and 735 km in a ν μ-dominated beam with a peak energy of 3 GeV. The data, from an exposure of 10.56 × 10 20 protons on target, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters θ 24 and Δm 41 2 and set limits on parameters of the four-dimensional Pontecorvo-Maki-Nakagawa-Sakata matrix, |U μ4| 2 and |U τ4| 2, under the assumption that mixing between νe and νs is negligible (|U e4| 2=0). No evidence for νmore » μ → ν s transitions is found and we set a world-leading limit on θ 24 for values of Δm 41 2 ≲ 1 eV 2.« less

Neutrino and C P -even Higgs boson masses in a nonuniversal U (1 )' extension

NASA Astrophysics Data System (ADS)

Mantilla, S. F.; Martinez, R.; Ochoa, F.

2017-05-01

We propose a new anomaly-free and family nonuniversal U (1 )' extension of the standard model with the addition of two scalar singlets and a new scalar doublet. The quark sector is extended by adding three exotic quark singlets, while the lepton sector includes two exotic charged lepton singlets, three right-handed neutrinos, and three sterile Majorana leptons to obtain the fermionic mass spectrum of the standard model. The lepton sector also reproduces the elements of the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) matrix and the squared-mass differences data from neutrino oscillation experiments. Also, analytical relations of the PMNS matrix are derived via the inverse seesaw mechanism, and numerical predictions of the parameters in both normal and inverse order scheme for the mass of the phenomenological neutrinos are obtained. We employed a simple seesawlike method to obtain analytical mass eigenstates of the C P -even 3 ×3 mass matrix of the scalar sector.

Miura-type transformations for lattice equations and Lie group actions associated with Darboux-Lax representations

NASA Astrophysics Data System (ADS)

Berkeley, George; Igonin, Sergei

2016-07-01

Miura-type transformations (MTs) are an essential tool in the theory of integrable nonlinear partial differential and difference equations. We present a geometric method to construct MTs for differential-difference (lattice) equations from Darboux-Lax representations (DLRs) of such equations. The method is applicable to parameter-dependent DLRs satisfying certain conditions. We construct MTs and modified lattice equations from invariants of some Lie group actions on manifolds associated with such DLRs. Using this construction, from a given suitable DLR one can obtain many MTs of different orders. The main idea behind this method is closely related to the results of Drinfeld and Sokolov on MTs for the partial differential KdV equation. Considered examples include the Volterra, Narita-Itoh-Bogoyavlensky, Toda, and Adler-Postnikov lattices. Some of the constructed MTs and modified lattice equations seem to be new.

Leptonic CP phase determined by an equation involving PMNS matrix elements

NASA Astrophysics Data System (ADS)

Ke, Hong-Wei; Zhou, Jia-Hui; Li, Xue-Qian

2017-04-01

Several approximate equalities among the matrix elements of the Cabibbo-Kobayashi-Maskawa (CKM) and Pontecorvo-Maki-Nakagawa-Sakata (PMNS) matrices imply that hidden symmetries may exist and be common for both quark and neutrino sectors. The charge parity (CP) phase of the CKM matrix ({δ }{CKM}) is involved in these equalities and can be investigated when these equalities turn into several equations. As we substitute those experimentally measured values of the three mixing angles into the equations for quarks, it is noted that one of the equations which holds exactly has a solution {δ }{CKM}=({68.95}-1.15+1.15)^\\circ . That value accords with ({69.1}-3.85+2.02)^\\circ determined from available data. Generalizing the scenario to the lepton sector, the same equality determines the leptonic CP phase {δ }{PMNS} to be ({275.20}-1.15+1.15)^\\circ . Thus we predict the value of {δ }{PMNS} from the equation. So far there is no direct measurement on {δ }{PMNS}, but a recent analysis based on the neutrino oscillation data prefers a phase close to 270°.

Thailand's downstream projects proliferate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-06-03

Thailand continues to press expansion and modernization of its downstream sector. Among recent developments: Construction of an olefins unit at Thailand's second major petrochemical complex and a worldscale aromatics unit in Thailand is threatened by rising costs. Thailand's National Petrochemical Corp (NPC) let a 9 billion yen contract to Mitsui Engineering and Shipbuilding Co. and C. Itoh and Co. for a dual fuel cogeneration power plant at its Mab Ta Phud, Rayong province, petrochemical complex. Financing is in place to flash a green light for a $530 million Belgian-Thai joint venture sponsoring a worldscale polyvinyl chloride/vinyl chloride monomer plant inmore » Thailand. Work is more than 50% complete on the $345 million second phase expansion of Thai Oil's Sri Racha refinery in Chon Buri province. Petroleum Authority of Thailand (PTT) endorsed a plan to install two more natural gas processing plants in Thailand to meet rapidly growing domestic demand for petroleum gas.« less

Characteristics of earthquake-induced turbidites in Beppu Bay, southwest Japan

NASA Astrophysics Data System (ADS)

Yamada, K.; Takemura, K.; Kuwae, M.; Ikehara, K.; Yamamoto, M.

2015-12-01

Beppu Bay is located at the western end of the arc-bisecting dextral fault (Median Tectonic Line) associated with the northwestward subduction of the Philippine Sea Plate. According to Itoh et al. (1998) and Itoh et al. (2014), the process of formation of the bay was divided into two stages. The older stage (5 to 1.5 Ma) was dominated by a northward-inclined half-graben, while a pull-apart stress resulting from the right-stepping of the MTL developed during the younger stage (1.5 Ma to present in particular, 0.7 Ma to present), so seamless sediments were clearly preserved in the bay. Recently, Kuwae et al. (2012) revealed that the hemipelagic sediments accompanied with some event layers (18 major event layers (> 1 cm thick) and 55 minor event layers (< 1 cm thick)) were deposited. The core was well dated based on AMS 14C ages of 42 bivalves. In this study, we investigated the lithology of the event layers to understand how the layers were deposited. As a result, major event layers are classified into five types based on difference in the grain composition and facies: turbidites (type A-C), tephras (type D), and others (type E). Type A (4 layers) is thick event layers with a basal sand division, middle laminated silt division, and upper clay division. Relatively heavy particles, such as minerals, are concentrated in the basal division with clear erosion. Type B (7 layers) is similar to type A, but lack the basal division. Type C (5 layers) is almost the same as type B, but contains gypsum. Type D (2 layers) consists of a large amount of volcanic glass without bottom erosion. Type E (1 layer) is different from all other types and distinguishes by black color coarse particles and relatively high magnetic susceptibility. In particular, type A event layers are deposited in 334, 617, 1685, and 1893 cal. yrs BP using our age-depth model. The deposition age of an event layer corresponds to Keicho-Bungo historical earthquake occurred in 354 cal. yrs BP (Usami, 1996). The

On Discontinuous Piecewise Linear Models for Memristor Oscillators

NASA Astrophysics Data System (ADS)

Amador, Andrés; Freire, Emilio; Ponce, Enrique; Ros, Javier

2017-06-01

In this paper, we provide for the first time rigorous mathematical results regarding the rich dynamics of piecewise linear memristor oscillators. In particular, for each nonlinear oscillator given in [Itoh & Chua, 2008], we show the existence of an infinite family of invariant manifolds and that the dynamics on such manifolds can be modeled without resorting to discontinuous models. Our approach provides topologically equivalent continuous models with one dimension less but with one extra parameter associated to the initial conditions. It is possible to justify the periodic behavior exhibited by three-dimensional memristor oscillators, by taking advantage of known results for planar continuous piecewise linear systems. The analysis developed not only confirms the numerical results contained in previous works [Messias et al., 2010; Scarabello & Messias, 2014] but also goes much further by showing the existence of closed surfaces in the state space which are foliated by periodic orbits. The important role of initial conditions that justify the infinite number of periodic orbits exhibited by these models, is stressed. The possibility of unsuspected bistable regimes under specific configurations of parameters is also emphasized.

Nova Scorpii 2011 = PNV J16551100-3838120

NASA Astrophysics Data System (ADS)

Waagen, Elizabeth O.

2011-06-01

Announces the discovery of Nova Scorpii 2011 = PNV J16551100-3838120 by John Seach (Chatsworth Island, NSW, Australia) on 2011 June 1.40 UT at magnitude 9.5 (DSLR + orange filter). Spectra by Bernard Heathcote (South Yarra, Vic, Australia) on Jun 2.4896 UT, A. Arai, T. Kajikawa, and M. Nagashima (Kyoto Sangyo University, Japan) on 2011 June 2.68 UT, and Masayuki Yamanaka and Ryosuke Itoh (Hiroshima University, Japan) on Jun 2 UT indicate a highly-reddened classical nova. Initially reported to the AAVSO by Seach and announced in AAVSO Special Notice #240 (Arne Henden) and IAU CBET 2735 (Daniel W. E. Green, ed.). The object was designated PNV J18102135-2305306 when posted on the Central Bureau's Transient Objects Confirmation Page (TOCP) webpage. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details, observations, and links to images. [Nova Sco 2011 subsequently assigned the name V1312 Sco

Manifestation of Nonuniversality of Lepton Interactions in Spontaneously Violated Mirror Symmetry

NASA Astrophysics Data System (ADS)

Dyatlov, I. T.

2018-03-01

Data from the LHCb experiments are indicative of a substantial distinction between the B → K (or K*) + e + e - and B → K (or K*) + μ + μ - branching ratios (April 2017). The branching ratio for the e+e- channel is substantially greater than that for the μ + μ - channel, whereas Standard Model (SM) calculations require that they be equal to each other. The above distinction may suggest the existence of a new interaction changing generations and discriminating between leptons that has couplings that are much greater than and are inverse in strength to the SM fermion couplings to the Higgs boson. Under conditions of spontaneously violated mirror symmetry, the coupling of SM particles to the second Higgs scalar that is inevitably present there and which is in principle heavy possesses precisely these properties. An inverse character of this coupling and its strength are not an additional hypothesis but a necessary condition for qualitatively reproducing, in addition, the observed charged-lepton mass hierarchy and the structure of weak lepton mixing—the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) matrix. Within the mirror model being considered, all properties of the new interaction, including its inverse character, are due to the hierarchical character of the quark and charged-lepton mass spectrum.

Prediction on neutrino Dirac and Majorana phases and absolute mass scale from the CKM matrix

NASA Astrophysics Data System (ADS)

Haba, Naoyuki; Yamada, Toshifumi

2018-03-01

In the type-I seesaw model, the lepton-flavor-mixing matrix (Pontecorvo-Maki-Nakagawa-Sakata matrix) and the quark-flavor-mixing matrix [Cabibbo-Kobayashi-Maskawa (CKM) matrix] may be connected implicitly through a relation between the neutrino Dirac Yukawa coupling YD and the quark Yukawa couplings. In this paper, we study whether YD can satisfy—in the flavor basis where the charged lepton Yukawa and right-handed neutrino Majorana mass matrices are diagonal—the relation YD∝diag (yd,ys,yb)VCKMT or YD∝diag (yu,yc,yt)VCKM* without contradicting the current experimental data on quarks and neutrino oscillations. We search for sets of values of the neutrino Dirac C P phase δC P, Majorana phases α2 , α3 , and the lightest active neutrino mass that satisfy either of the above relations, with the normal or inverted hierarchy of neutrino masses. In performing the search, we consider renormalization group evolutions of the quark masses and CKM matrix and the propagation of their experimental errors along the evolutions. We find that only the former relation YD∝diag (yd,ys,yb)VCKMT with the normal neutrino mass hierarchy holds, based on which we make predictions for δC P, α2, α3, and the lightest active neutrino mass.

Observation of Electron Neutrino Appearance in a Muon Neutrino Beam

NASA Astrophysics Data System (ADS)

Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Ariga, T.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Bentham, S. W.; Berardi, V.; Berger, B. E.; Berkman, S.; Bertram, I.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dufour, F.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Floetotto, L.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Gaudin, A.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gomez-Cadenas, J. J.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Ives, S. J.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kumaratunga, S.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Lamont, I.; Laveder, M.; Lawe, M.; Lazos, M.; Lee, K. P.; Licciardi, C.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Ludovici, L.; Macaire, M.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Maruyama, T.; Marzec, J.; Mathie, E. L.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Missert, A.; Miura, M.; Monfregola, L.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagasaki, T.; Nakadaira, T.; Nakahata, M.; Nakai, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Naples, D.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Owen, R. A.; Oyama, Y.; Palladino, V.; Paolone, V.; Payne, D.; Pearce, G. F.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L. J.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Retiere, F.; Robert, A.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smith, R. J.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Ueno, K.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

2014-02-01

The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3σ when compared to 4.92±0.55 expected background events. In the Pontecorvo-Maki-Nakagawa-Sakata mixing model, the electron neutrino appearance signal depends on several parameters including three mixing angles θ12, θ23, θ13, a mass difference Δm322 and a CP violating phase δCP. In this neutrino oscillation scenario, assuming |Δm322|=2.4×10-3 eV2, sin2θ23=0.5, and Δm322>0 (Δm322<0), a best-fit value of sin22θ13=0.140-0.032+0.038 (0.170-0.037+0.045) is obtained at δCP=0. When combining the result with the current best knowledge of oscillation parameters including the world average value of θ13 from reactor experiments, some values of δCP are disfavored at the 90% C.L.

Finding Mass Constraints Through Third Neutrino Mass Eigenstate Decay

NASA Astrophysics Data System (ADS)

Gangolli, Nakul; de Gouvêa, André; Kelly, Kevin

2018-01-01

In this paper we aim to constrain the decay parameter for the third neutrino mass utilizing already accepted constraints on the other mixing parameters from the Pontecorvo-Maki-Nakagawa-Sakata matrix (PMNS). The main purpose of this project is to determine the parameters that will allow the Jiangmen Underground Neutrino Observatory (JUNO) to observe a decay parameter with some statistical significance. Another goal is to determine the parameters that JUNO could detect in the case that the third neutrino mass is lighter than the first two neutrino species. We also replicate the results that were found in the JUNO Conceptual Design Report (CDR). By utilizing Χ2-squared analysis constraints have been put on the mixing angles, mass squared differences, and the third neutrino decay parameter. These statistical tests take into account background noise and normalization corrections and thus the finalized bounds are a good approximation for the true bounds that JUNO can detect. If the decay parameter is not included in our models, the 99% confidence interval lies within The bounds 0s to 2.80x10-12s. However, if we account for a decay parameter of 3x10-5 ev2, then 99% confidence interval lies within 8.73x10-12s to 8.73x10-11s.

Activation mechanism of melB tyrosinase from Aspergillus oryzae by acidic treatment.

PubMed

Fujieda, Nobutaka; Murata, Michiaki; Yabuta, Shintaro; Ikeda, Takuya; Shimokawa, Chizu; Nakamura, Yukihiro; Hata, Yoji; Itoh, Shinobu

2013-01-01

The pro form of recombinant tyrosinase from Aspergillus oryzae (melB) shows no catalytic activity, but acid treatment (around pH 3.5) of protyrosinase activates it to induce tyrosinase activity. Circular dichroism spectra, gel filtration analysis, and colorimetric assay have indicated that acid treatment around pH 3.5 induced the disruption of the conformation of the C-terminal domain covering the enzyme active site. These structural changes induced by the acid treatment may open the entrance to the enzyme active site for substrate incorporation. To compare the mechanism of hydroxylation by the acid-treated tyrosinase with that by trypsin-treated tyrosinase, a detailed steady-state kinetic analysis of the phenolase activity was performed by monitoring the O(2)-consumption rate using a Clark-type oxygen electrode. The results clearly show that the phenolase activity (phenol hydroxylation) of the activated tyrosinase involves an electrophilic aromatic substitution mechanism as in the case of mushroom tyrosinase (Yamazaki and Itoh in J. Am. Chem. Soc. 125:13034-13035, 2003) and activated hemocyanin with urea (Morioka et al. in J. Am. Chem. Soc. 128:6788-6789, 2006).

Approximate Equation of State for Overdriven and Reflected Detonation Products

NASA Astrophysics Data System (ADS)

Liu, Zhi-Yue; Itoh, Shigeru

2001-06-01

Approximate Equation of State for Overdriven and Reflected Detonation Products Zhi-Yue Liu and Shigeru Itoh Shock Wave and Condensed Matter Research Center, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan ABSTRACT There are several types of equations of state (EOS) to describe the isentropic expansion behavior of the detonation products after the explosive is exploded. Of which, Jones-Wilkins-Lee (or JWL) equation and polytropic gas (or gamma-law) equation are most popularly employed owing to either the completely experimental calibration or simple form in expression. However, both equations fail to correctly describe the behavior of detonation products above the Chapman-Jouguet (C-J) state. For this reason, a new form of equation of state is proposed for overcoming this deficiency. The new equation of state is simply a linear combination of JWL and gamma-law equations. The coefficient appeared in the EOS can be obtained by fitting to the data from the overdriven detonation experiments. Results show that this form of EOS not only gives the satisfactory description to the variation of the detonation products in overdriven or reflected state also can simply be incorporated into the hydrodynamic computer codes.

Dishevelled-induced phosphorylation regulates membrane localization of Par1b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terabayashi, Takeshi; Funato, Yosuke; Miki, Hiroaki, E-mail: hmiki@protein.osaka-u.ac.jp

2008-10-31

Par1b is an evolutionarily conserved kinase that plays crucial roles in cell polarity. Controlling intracellular localization of Par1b is important for its biological activity. We previously reported that Wnt stimulation or expression of Dvl promotes accumulation of Par1b in the membrane (T. Terabayashi, T.J. Itoh, H. Yamaguchi, Y. Yoshimura, Y. Funato, S. Ohno, H. Miki, Polarity-Regulating Kinase Partitioning-Defective 1/Microtubule Affinity-Regulating Kinase 2 Negatively Regulates Development of Dendrites on Hippocampal Neurons, J. Neurosci. 27 (2007) 13098-13107). However, its molecular mechanism remains unclear. Here we show the importance of Par1b phosphorylation in the regulation of membrane localization. We find that Thr-324 ismore » phosphorylated in a Dvl-dependent manner. Interestingly, the conversion of Thr-324 to Glu results in a significant accumulation of Par1b in the membrane, without any effects on the kinase activity. Moreover, the phospho-mimicking Par1b mutant does not antagonistically function against Dvl in microtubule stabilization and neurite extension, although wildtype Par1b does. These results suggest that membrane accumulation of Par1b induced by Dvl is regulated by its phosphorylation status, which is important for Par1b to regulate the microtubule dynamics.« less

Testing constrained sequential dominance models of neutrinos

NASA Astrophysics Data System (ADS)

Björkeroth, Fredrik; King, Stephen F.

2015-12-01

Constrained sequential dominance (CSD) is a natural framework for implementing the see-saw mechanism of neutrino masses which allows the mixing angles and phases to be accurately predicted in terms of relatively few input parameters. We analyze a class of CSD(n) models where, in the flavour basis, two right-handed neutrinos are dominantly responsible for the ‘atmospheric’ and ‘solar’ neutrino masses with Yukawa couplings to ({ν }e,{ν }μ ,{ν }τ ) proportional to (0,1,1) and (1,n,n-2), respectively, where n is a positive integer. These coupling patterns may arise in indirect family symmetry models based on A 4. With two right-handed neutrinos, using a χ 2 test, we find a good agreement with data for CSD(3) and CSD(4) where the entire Pontecorvo-Maki-Nakagawa-Sakata mixing matrix is controlled by a single phase η, which takes simple values, leading to accurate predictions for mixing angles and the magnitude of the oscillation phase | {δ }{CP}| . We carefully study the perturbing effect of a third ‘decoupled’ right-handed neutrino, leading to a bound on the lightest physical neutrino mass {m}1{{≲ }}1 meV for the viable cases, corresponding to a normal neutrino mass hierarchy. We also discuss a direct link between the oscillation phase {δ }{CP} and leptogenesis in CSD(n) due to the same see-saw phase η appearing in both the neutrino mass matrix and leptogenesis.

Neutrino oscillations: The rise of the PMNS paradigm

NASA Astrophysics Data System (ADS)

Giganti, C.; Lavignac, S.; Zito, M.

2018-01-01

Since the discovery of neutrino oscillations, the experimental progress in the last two decades has been very fast, with the precision measurements of the neutrino squared-mass differences and of the mixing angles, including the last unknown mixing angle θ13. Today a very large set of oscillation results obtained with a variety of experimental configurations and techniques can be interpreted in the framework of three active massive neutrinos, whose mass and flavour eigenstates are related by a 3 × 3 unitary mixing matrix, the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) matrix, parametrized by three mixing angles θ12, θ23, θ13 and a CP-violating phase δCP. The additional parameters governing neutrino oscillations are the squared-mass differences Δ mji2 = mj2 - mi2, where mi is the mass of the ith neutrino mass eigenstate. This review covers the rise of the PMNS three-neutrino mixing paradigm and the current status of the experimental determination of its parameters. The next years will continue to see a rich program of experimental endeavour coming to fruition and addressing the three missing pieces of the puzzle, namely the determination of the octant and precise value of the mixing angle θ23, the unveiling of the neutrino mass ordering (whether m1

A new possible picture of the hadron structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pokrovsky, Yury E.

A new chiral-scale invariant version of the bag model (CSB) is developed and applied to calculations of masses and radii for single bag states. The mass formula of the CSB model contains no free parameters and connects masses and radii of the bags with fundamental QCD scales, namely with {lambda}{sub QCD}, , , and quark masses. For high angular momentum states the CSB model well describes hadron Regge trajectories and predicts thin flux tubes with R{sub tube}{approx_equal}0.25 fm close to the small tube radii introduced a posteriori in modern models. For low angular momentum states this model predicts smallmore » radii of the bags R{sub bag}{approx_equal}0.25 fm close to the radii associated with constituent quarks. Masses of the lowest angular momentum bags are obtained close to the data for well known hadron resonances ({pi}(1300), {omega}(1420), N(1440),{delta}(1600), etc.). These resonances are predicted to be almost single bag states. But ground states of SU(3) hadrons (N(940), {pi}(140), etc.) are treated as strongly bounded multi bag states--BagBag-mesons, and BagBagBag-baryons like in the old Fermi, Yang, and Sakata models. As well, this model predicts the low mass excitations of SU(3) hadrons newly observed for nucleons at the following masses 1004, 1044, and 1094 MeV.« less

Solid perception mechanism by a shading pattern: spatial frequency components in a corrugated wave pattern.

PubMed

Nameda, N

1988-01-01

Illumination allows solid object perception to be obtained and depicted by a shading pattern produced by lighting. The shading cue, as one of solid perception cues (Gibson 1979), was investigated in regard to a white corrugated wave shape, using computer graphic device: Tospix-2. The reason the corrugated wave was chosen, is that an alternately bright and dark pattern, produced by shading, can be conveniently analyzed into contained spatial frequencies. This paper reports spatial frequency properties contained in the shading pattern. The shading patterns, input into the computer graphic device, are analyzed by Fourier Transformation by the same device. After the filtration by various spatial frequency low and high pass filters, Inverse Fourier Transformation is carried out for the residual components. The result of the analysis indicates that the third through higher harmonics components are important in regard to presenting a solid reality feeling in solid perception. Sakata (1983) also reported that an edged pattern, superimposed onto a lower sinusoidal pattern, was important in solid perception. The third through higher harmonics components express the changing position of luminance on the pattern, and a slanted plane relating to the light direction. Detection of a solid shape, constructed with flat planes, is assumed to be on the bottom of the perfect curved solid perception mechanism. Apparent evidence for this assumption, in difficult visual conditions, is that a flat paneled solid is seen before the curved solid. This mechanism is explained by two spatial frequency neural network systems, assumed as having correspondence with higher spatial frequency detection and lower spatial frequency detection.

Two tyrosyl radicals stabilize high oxidation states in cytochrome c oxidase for efficient energy conservation and proton translocation

NASA Astrophysics Data System (ADS)

Rousseau, Denis

2012-02-01

The reaction of hydrogen peroxide (H2O2) with oxidized bovine cytochrome c oxidase (bCcO) was studied by electron paramagnetic resonance (EPR) to determine the properties of radical intermediates. Two distinct radicals with widths of 12 and 46 G are directly observed by X-band CW-EPR in the reaction of bCcO with H2O2 at pH 6 and pH 8. High-frequency EPR (D-band) provides assignments to tyrosine for both radicals based on well-resolved g-tensors. The 46 G wide radical has extensive hyperfine structure and can be fit with parameters consistent with Y129. However, the 12 G wide radical has minimal hyperfine structure and can be fit using parameters unique to the post-translationally modified Y244 in CcO. The results are supported by mixed quantum mechanics and molecular mechanics calculations. This study reports spectroscopic evidence of a radical formed on the modified tyrosine in CcO and resolves the much debated controversy of whether the wide radical seen at low pH in the bovine system is a tyrosine or tryptophan. A model is presented showing how radical formation and migration may play an essential role in proton translocation. This work was done in collaboration with Michelle A. Yu, Tsuyoshi Egawa, Syun-Ru Yeh and Gary J. Gerfen from Albert Einstein College of Medicine; Kyoko Shinzawa-Itoh and Shinya Yoshikawa from the University of Hyogo; and Victor Guallar from the Barcelona Supercomputing Center.

Item response theory-based validation of a short form of the Eating Behavior Scale for Japanese adults

PubMed Central

Tayama, Jun; Ogawa, Sayaka; Takeoka, Atsushi; Kobayashi, Masakazu; Shirabe, Susumu

2017-01-01

Abstract Obesity has become a serious social problem in industrialized countries in recent years. Clinically, although the evaluation of dietary behavior abnormalities is as important as any method of risk assessment for obesity, almost all the existing scales with many items may have numerous practical clinical difficulties. In this study, we aimed to prepare a short questionnaire to assess the dietary behavior abnormalities related to obesity. A total of 1032 individuals aged 20 to 59 years participated in the present study. Using item response theory (IRT), we selected the items for a short version from among 30 items of Sakata Eating Behavior Scale (EBS), which is widely used in Japan. As a result of the IRT-based analysis on the original 30-item version, 7 items were adopted as the short version. The correlation between the total score of the original EBS and the EBS short form was extremely high (r = 0.93, P = .001). In examining the criterion validity, for all participants (n = 1032), male (n = 516), and female (n = 516), the correlation coefficients between the total score of the EBS short form and body mass index (BMI) were r = 0.26, r = 0.28, and r = 0.28, respectively. The results of the receiver operating characteristic analysis was performed with obesity BMI > 25 kg/m2 as a dependent variable, the value of the area under the curve in the ROC was significantly higher in the 7-item version than in the total score of the original items (P = .0005). In conclusion, the 7-item EBS short form was created. Furthermore, it was found that the EBS short form is a reliable and valid measure that can be used as an indicator of obesity in both clinical and research settings. PMID:29049248

Distinct patterns of desynchronized limb regression in malagasy scincine lizards (squamata, scincidae).

PubMed

Miralles, Aurélien; Hipsley, Christy A; Erens, Jesse; Gehara, Marcelo; Rakotoarison, Andolalao; Glaw, Frank; Müller, Johannes; Vences, Miguel

2015-01-01

Scincine lizards in Madagascar form an endemic clade of about 60 species exhibiting a variety of ecomorphological adaptations. Several subclades have adapted to burrowing and convergently regressed their limbs and eyes, resulting in a variety of partial and completely limbless morphologies among extant taxa. However, patterns of limb regression in these taxa have not been studied in detail. Here we fill this gap in knowledge by providing a phylogenetic analysis of DNA sequences of three mitochondrial and four nuclear gene fragments in an extended sampling of Malagasy skinks, and microtomographic analyses of osteology of various burrowing taxa adapted to sand substrate. Based on our data we propose to (i) consider Sirenoscincus Sakata & Hikida, 2003, as junior synonym of Voeltzkowia Boettger, 1893; (ii) resurrect the genus name Grandidierina Mocquard, 1894, for four species previously included in Voeltzkowia; and (iii) consider Androngo Brygoo, 1982, as junior synonym of Pygomeles Grandidier, 1867. By supporting the clade consisting of the limbless Voeltzkowia mira and the forelimb-only taxa V. mobydick and V. yamagishii, our data indicate that full regression of limbs and eyes occurred in parallel twice in the genus Voeltzkowia (as hitherto defined) that we consider as a sand-swimming ecomorph: in the Voeltzkowia clade sensu stricto the regression first affected the hindlimbs and subsequently the forelimbs, whereas the Grandidierina clade first regressed the forelimbs and subsequently the hindlimbs following the pattern prevalent in squamates. Timetree reconstructions for the Malagasy Scincidae contain a substantial amount of uncertainty due to the absence of suitable primary fossil calibrations. However, our preliminary reconstructions suggest rapid limb regression in Malagasy scincids with an estimated maximal duration of 6 MYr for a complete regression in Paracontias, and 4 and 8 MYr respectively for complete regression of forelimbs in Grandidierina and

Distinct Patterns of Desynchronized Limb Regression in Malagasy Scincine Lizards (Squamata, Scincidae)

PubMed Central

Miralles, Aurélien; Hipsley, Christy A.; Erens, Jesse; Gehara, Marcelo; Rakotoarison, Andolalao; Glaw, Frank; Müller, Johannes; Vences, Miguel

2015-01-01

Scincine lizards in Madagascar form an endemic clade of about 60 species exhibiting a variety of ecomorphological adaptations. Several subclades have adapted to burrowing and convergently regressed their limbs and eyes, resulting in a variety of partial and completely limbless morphologies among extant taxa. However, patterns of limb regression in these taxa have not been studied in detail. Here we fill this gap in knowledge by providing a phylogenetic analysis of DNA sequences of three mitochondrial and four nuclear gene fragments in an extended sampling of Malagasy skinks, and microtomographic analyses of osteology of various burrowing taxa adapted to sand substrate. Based on our data we propose to (i) consider Sirenoscincus Sakata & Hikida, 2003, as junior synonym of Voeltzkowia Boettger, 1893; (ii) resurrect the genus name Grandidierina Mocquard, 1894, for four species previously included in Voeltzkowia; and (iii) consider Androngo Brygoo, 1982, as junior synonym of Pygomeles Grandidier, 1867. By supporting the clade consisting of the limbless Voeltzkowia mira and the forelimb-only taxa V. mobydick and V. yamagishii, our data indicate that full regression of limbs and eyes occurred in parallel twice in the genus Voeltzkowia (as hitherto defined) that we consider as a sand-swimming ecomorph: in the Voeltzkowia clade sensu stricto the regression first affected the hindlimbs and subsequently the forelimbs, whereas the Grandidierina clade first regressed the forelimbs and subsequently the hindlimbs following the pattern prevalent in squamates. Timetree reconstructions for the Malagasy Scincidae contain a substantial amount of uncertainty due to the absence of suitable primary fossil calibrations. However, our preliminary reconstructions suggest rapid limb regression in Malagasy scincids with an estimated maximal duration of 6 MYr for a complete regression in Paracontias, and 4 and 8 MYr respectively for complete regression of forelimbs in Grandidierina and

Interobserver variability of ultrasound elastography and the ultrasound BI-RADS lexicon of breast lesions.

PubMed

Park, Chang Suk; Kim, Sung Hun; Jung, Na Young; Choi, Jae Jung; Kang, Bong Joo; Jung, Hyun Seouk

2015-03-01

Elastographpy is a newly developed noninvasive imaging technique that uses ultrasound (US) to evaluate tissue stiffness. The interpretation of the same elastographic images may be variable according to reviewers. Because breast lesions are usually reported according to American College of Radiology Breast Imaging and Data System (ACR BI-RADS) lexicons and final category, we tried to compare observer variability between lexicons and final categorization of US BI-RADS and the elasticity score of US elastography. From April 2009 to February 2010, 1356 breast lesions in 1330 patients underwent ultrasound-guided core biopsy. Among them, 63 breast lesions in 55 patients (mean age, 45.7 years; range, 21-79 years) underwent both conventional ultrasound and elastography and were included in this study. Two radiologists independently performed conventional ultrasound and elastography, and another three observers reviewed conventional ultrasound images and elastography videos. Observers independently recorded the elasticity score for a 5-point scoring system proposed by Itoh et al., BI-RADS lexicons and final category using ultrasound BI-RADS. The histopathologic results were obtained and used as the reference standard. Interobserver variability was evaluated. Of the 63 lesions, 42 (66.7 %) were benign, and 21 (33.3 %) were malignant. The highest value of concordance among all variables was achieved for the elasticity score (k = 0.59), followed by shape (k = 0.54), final category (k = 0.48), posterior acoustic features (k = 0.44), echogenecity and orientation (k = 0.43). The least concordances were margin (k = 0.26), lesion boundary (k = 0.29) and calcification (k = 0.3). Elasticity score showed a higher level of interobserver agreement for the diagnosis of breast lesions than BI-RADS lexicons and final category.

Evaluation of interobserver variability of parenchymal phase of Tc-99m mercaptoacetyltriglycine and Tc-99m dimercaptosuccinic acid renal scintigraphy

PubMed Central

Erdoğan, Zeynep; Abdülrezzak, Ümmühan; Silov, Güler; Özdal, Ayşegül; Turhal, Özgül

2014-01-01

Objective: The aim of this study was to investigate the variability in the interpretation of parenchymal abnormalities and to assess the differences in interpretation of routine renal scintigraphic findings on posterior view of technetium-99m dimercaptosuccinic acid (pvDMSA) scans and parenchymal phase of technetium-99m mercaptoacetyltriglycine (ppMAG3) scans by using standard criterions to make standardization and semiquantitative evaluation and to have more accurately correlation. Materials and Methods: Two experienced nuclear medicine physicians independently interpreted pvDMSA scans of 204 and ppMAG3 scans of 102 pediatric patients, retrospectively. Comparisons were made by visual inspection of pvDMSA scans, and ppMAG3 scans by using a grading system modified from Itoh et al. According to this, anatomical damage of the renal parenchyma was classified into six types: Grade 0-V. In the calculation of the agreement rates, Kendall correlation (tau-b) analysis was used. Results: According to our findings, excellent agreement was found for DMSA grade readings (DMSA-GR) (tau-b = 0.827) and good agreement for MAG3 grade readings (MAG3-GR) (tau-b = 0.790) between two observers. Most of clear parenchymal lesions detected on pvDMSA scans and ppMAG3 scans identified by observers equally. Studies with negative or minimal lesions reduced correlation degrees for both DMSA-GR and MAG3-GR. Conclusion: Our grading system can be used for standardization of the reports. We conclude that standardization of criteria and terminology in the interpretations may result in higher interobserver consistency, also improve low interobserver reproducibility and objectivity of renal scintigraphy reports. PMID:24761059

List of participants at SIDE IV meeting, Tokyo, 27 November--1 December 2000

NASA Astrophysics Data System (ADS)

2001-12-01

Mark J Ablowitz, Vsevolod Adler, Mark Alber, Said Belmehdi, Marco Boiti, Claude Brezinski, R Bullough, Y M Chiang, Theodore Chihara, Peter A Clarkson, Robert Conte, Adam Doliwa, Vladimir Dorodnitsyn, Mitsuaki Eguchi, Claire Gilson, Basil Grammaticos, Valeri Gromak, Rod Halburd, Koji Hasegawa, Jarmo Hietarinta, Ryogo Hirota, Xing Biao Hu, M Idzumi, J Inoguchi, Hiroya Ishikara, Mourad Ismail, Shin Isojima, Kenichi Ito, Yoshiaki Itoh, Masashi Iwasaki, Klara Janglajew, Michio Jimbo, Nalini Joshi, Kenji Kajiwara, Saburo Kakei, Masaru Kamata, Satoshi Kamei, Rinat Kashaev, Shingo Kawai, Taeko Kimijima, K Kimura, Anatol Kirillov, Koichi Kondo, Boris Konopelchenko, Martin Kruskal, Atsuo Kuniba, Wataru Kunishima, Franklin Lambert, Serguei Leble, Decio Levi, Shigeru Maeda, Manuel Manas, Ken-Ichi Maruno, Tetsu Masuda, J Matsukidaira, Atsushi Matsumiya, Shigeki Matsutani, Yukitaka Minesaki, Mikio Murata, Micheline Musette, Atsushi Nagai, Katsuya Nakagawa, Atsushi Nakamula, Akira Nakamura, Yoshimasa Nakamura, Frank Nijhoff, J J C Nimmo, Katsuhiro Nishinari, Michitomo Nishizawa, A Nobe, Masatoshi Noumi, Yaeko Ohsaki, Yasuhiro Ohta, Kazuo Okamoto, Alexandre Orlov, Naoki Osada, Flora Pempinelli, Spiro Pyrlis, Reinout Quispel, Orlando Ragnisco, Alfred Ramani, Jean-Pierre Ramis, Andreas Ruffing, Simon Ruijsenaars, Satoru Saito, Noriko Saitoh, Hidetaka Sakai, Paulo Santini, Narimasa Sasa, Ryu Sasaki, Yoshikatsu Sasaki, Junkichi Satsuma, Sergei Sergeev, Nobuhiko Shinzawa, Evgueni Sklyanin, Juris Suris, Norio Suzuki, Yukiko Tagami, Katsuaki Takahashi, Daisuke Takahashi, Tomoyuki Takenawa, Yoshiro Takeyama, K M Tamizhmani, T Tamizhmani, Kouichi Toda, Morikatsu Toda, Tetsuji Tokihiro, Takayuki Tsuchida, Yohei Tsuchiya, Teruhisa Tsuda, Satoru Tsujimoto, Walter Van Assche, Claude Viallet, Luc Vinet, Shinsuke Watanabe, Yoshihida Watanabe, Ralph Willox, Pavel Winternitz, Yasuhiko Yamada, Yuji Yamada, Jin Yoneda, Haruo Yoshida, Katsuhiko Yoshida, Daisuke Yoshihara, Fumitaka Yura, J

Sinusoidal modulation analysis for optical system MTF measurements.

PubMed

Boone, J M; Yu, T; Seibert, J A

1996-12-01

The modulation transfer function (MTF) is a commonly used metric for defining the spatial resolution characteristics of imaging systems. While the MTF is defined in terms of how an imaging system demodulates the amplitude of a sinusoidal input, this approach has not been in general use to measure MTFs in the medical imaging community because producing sinusoidal x-ray patterns is technically difficult. However, for optical systems such as charge coupled devices (CCD), which are rapidly becoming a part of many medical digital imaging systems, the direct measurement of modulation at discrete spatial frequencies using a sinusoidal test pattern is practical. A commercially available optical test pattern containing spatial frequencies ranging from 0.375 cycles/mm to 80 cycles/mm was sued to determine the MRF of a CCD-based optical system. These results were compared with the angulated slit method of Fujita [H. Fujita, D. Tsia, T. Itoh, K. Doi, J. Morishita, K. Ueda, and A. Ohtsuka, "A simple method for determining the modulation transfer function in digital radiography," IEEE Trans. Medical Imaging 11, 34-39 (1992)]. The use of a semiautomated profiled iterated reconstruction technique (PIRT) is introduced, where the shift factor between successive pixel rows (due to angulation) is optimized iteratively by least-squares error analysis rather than by hand measurement of the slit angle. PIRT was used to find the slit angle for the Fujita technique and to find the sine-pattern angle for the sine-pattern technique. Computer simulation of PIRT for the case of the slit image (a line spread function) demonstrated that it produced a more accurate angle determination than "hand" measurement, and there is a significant difference between the errors in the two techniques (Wilcoxon Signed Rank Test, p < 0.001). The sine-pattern method and the Fujita slit method produced comparable MTF curves for the CCD camera evaluated.

The α-Amylase Induction in Endosperm during Rice Seed Germination Is Caused by Gibberellin Synthesized in Epithelium1

PubMed Central

Kaneko, Miyuki; Itoh, Hironori; Ueguchi-Tanaka, Miyako; Ashikari, Motoyuki; Matsuoka, Makoto

2002-01-01

We recently isolated two genes (OsGA3ox1 and OsGA3ox2) from rice (Oryza sativa) encoding 3β-hydroxylase, which catalyzes the final step of active gibberellin (GA) biosynthesis (H. Itoh, M. Ueguchi-Tanaka, N. Sentoku, H. Kitano, M. Matsuoka, M. Kobayashi [2001] Proc Natl Acad Sci USA 98: 8909–8914). Using these cloned cDNAs, we analyzed the temporal and spatial expression patterns of the 3β-hydroxylase genes and also an α-amylase gene (RAmy1A) during rice seed germination to investigate the relationship between GA biosynthesis and α-amylase expression. Northern-blot analyses revealed that RAmy1A expression in the embryo occurs before the induction of 3β-hydroxylase expression, whereas in the endosperm, a high level of RAmy1A expression occurs 1 to 2 d after the peak of OsGA3ox2 expression and only in the absence of uniconazol. Based on the analysis of an OsGA3ox2 null mutant (d18-Akibare dwarf), we determined that 3β-hydroxylase produced by OsGA3ox2 is important for the induction of RAmy1A expression and that the OsGA3ox1 product is not essential for α-amylase induction. The expression of OsGA3ox2 was localized to the shoot region and epithelium of the embryo, strongly suggesting that active GA biosynthesis occurs in these two regions. The synthesis of active GA in the epithelium is important for α-amylase expression in the endosperm, because an embryonic mutant defective in shoot formation, but which developed epithelium cells, induced α-amylase expression in the endosperm, whereas a mutant defective in epithelium development did not. PMID:11950975

Kiso Multi-Fiber Spectroscope Project (C)

NASA Astrophysics Data System (ADS)

Yadoumaru, Yasushi; Itoh, Nobunari; Nakada, Yoshikazu; Tarusawa, Ken'ichi; Soyano, Takao; Mito, Hiroyuki

A Multi-FIBER Spectroscope at Kiso Observatory is under consideration as our next instrument. In this paper we report an overview of our instrument and a scientific target of our survey project. We are going to attach multi-fiber system at the prime focus of Kiso 105cm Schmidt telescope. This telescope has some advantages for our project. First, the efficiency in survey for the object, which number density is 0.1 to 10 degree2, is higher than other multi object system due to the wide field of view (6 degree x 6 degree). Second, an optics of telescope is well-matched to fiber numerical aperture (NA) at an input end of fiber. Moreover, taking a focal ratio degradation (FRD) and scrambling property into account, since the light from object dose not move at the entrance slit of spectroscope, we could get spectroscopic data stably with this system. We select a fiber with 100 micron meter core which is correspond to 6 arcsec on focal plane, that is matched with a typical seeing (about 3 arcsec) of Kiso Observatory and set 150 fibers to one field. For efficient observations, it is necessary to arrange fibers accurately within an accuracy of +/- 25 micron meter on the curved focal plane during a typical exposure time (1 hour). Therefore we examine a particular positioner specialized for curved surface. We also develop a spectroscope that is suited for a fast focal ratio and proceed with making its design. One of our main key projects with this system is a non-biased metallicity survey for solar neighbor stars. We are now establishing a new metallicity determination method that easily and reliably measures a metallicity from low-dispersion spectra. (see Itoh et al.). As we consider our main target as Galactic objects and low resolution (R is around 1000), we could observe a star with 17 mag at V-band (1 hour exposure).

Application of the windowed-Fourier-transform-based fringe analysis technique for investigating temperature and concentration fields in fluids.

PubMed

Mohanan, Sharika; Srivastava, Atul

2014-04-10

The present work is concerned with the development and application of a novel fringe analysis technique based on the principles of the windowed-Fourier-transform (WFT) for the determination of temperature and concentration fields from interferometric images for a range of heat and mass transfer applications. Based on the extent of the noise level associated with the experimental data, the technique has been coupled with two different phase unwrapping methods: the Itoh algorithm and the quality guided phase unwrapping technique for phase extraction. In order to generate the experimental data, a range of experiments have been carried out which include cooling of a vertical flat plate in free convection conditions, combustion of mono-propellant flames, and growth of organic as well as inorganic crystals from their aqueous solutions. The flat plate and combustion experiments are modeled as heat transfer applications wherein the interest is to determine the whole-field temperature distribution. Aqueous-solution-based crystal growth experiments are performed to simulate the mass transfer phenomena and the interest is to determine the two-dimensional solute concentration field around the growing crystal. A Mach-Zehnder interferometer has been employed to record the path-integrated quantity of interest (temperature and/or concentration) in the form of interferometric images in the experiments. The potential of the WFT method has also been demonstrated on numerically simulated phase data for varying noise levels, and the accuracy in phase extraction have been quantified in terms of the root mean square errors. Three levels of noise, i.e., 0%, 10%, and 20% have been considered. Results of the present study show that the WFT technique allows an accurate extraction of phase values that can subsequently be converted into two-dimensional temperature and/or concentration distribution fields. Moreover, since WFT is a local processing technique, speckle patterns and the inherent

When Do Short-Wave Cones Signal Blue or Red? A Solution Introducing the Concept of Primary and Secondary Cone Outputs

PubMed Central

2016-01-01

A recent paper by Oh and Sakata investigates the “incompletely solved mystery” of how the three cone responses map onto perceived hue, and particularly the S cone’s well-known problematic contribution to blueness and redness. Citing previous workers, they argue the twentieth century traditional multistage model does not satisfactorily account for color appearance. In their experiment, increasing S cone excitation with shortening wavelength from about 480–460 nm increased perceived blueness up to the unique Blue point at 470 nm, when (a) it began decreasing and (b) redness perception began increasing. The authors asked, What mechanism can be responsible for such functions? I demonstrate a solution. First, it is shown the problem does not lie in the traditional opponent color chromatic responses yellow-blue, red-green (y-b, r-g, which accurately predict the above functions), but in the traditional multistage model of mapping cone responses to chromatic response functions. Arguably, this is due to the S cone’s hypothetically signaling both blueness and redness by the same mechanism rather than by different, independent, mechanisms. Hence a new distinction or mechanism is proposed for a more accurate model, that introduces the new terms primary and secondary cone outputs. However, this distinction requires that the cones S, M, L each directly produce one of the three spectral chromatic responses b, g, y. Such a model was recently published, based on extremely high correlation of SML cone responsivities with the three spectral (bgy) chromatic responses. This model encodes the former directly onto the latter one-to-one as cone primary outputs, whilst S and L cones have a further or secondary function where each produces one of the two spectral lobes of r chromatic response. The proposed distinction between primary and secondary cone outputs is a new concept and useful tool in detailing cone outputs to chromatic channels, and provides a solution to the above �

Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Satoh, Takumi; Saitoh, Sachie; Hosaka, Manami

2009-02-06

Electrophilic compounds protect neurons through the activation of the Keap1/Nrf2 pathway and the induction of phase-2 enzymes [T. Satoh, S.A. Lipton, Redox regulation of neuronal survival by electrophilic compounds, Trends Neurosci. 30 (2007) 38-45; T. Satoh, S. Okamoto, J. Cui, Y. Watanabe, K. Furuta, M. Suzuki, K. Tohyama, S.A. Lipton, Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic phase II inducers. Proc. Natl. Acad. Sci. USA 103 (2006) 768-773]. Hydroquinone-type electrophilic compounds such as tert-butyl hydroquinone (TBHQ) and carnosic acid (CA) have attracted special attention, because the oxidative conversion of 'hydroquinone' to 'quinone' is essential for the transcriptional activationmore » of the above-mentioned enzymes [T. Satoh, K. Kosaka, K. Itoh, A. Kobayashi, M. Yamamoto, Y. Shimojo, C. Kitajima, J. Cui, J. Kamins, S. Okamoto, T. Shirasawa, S.A. Lipton, Carnosic acid, a catechol-type electrophilic compound, protect neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of specific cysteine, J. Neurochem. 104 (2008) 1161-1131; A.D. Kraft, D.A. Johnson, J.A. Johnson, Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult, J. Neurosci. 24 (2004) 1101-1112]. In the present study, we examined the relationship between electrophilicity and the protective effects afforded by electrophilic compounds. Electrophilicity was assessed in terms of the ability of a compound to bind to a cysteine on bovine serum albumin, by which we found that neuroprotective hydroquinones [TBHQ (para-) and CA (ortho-)] had distinctive patterns of cysteine binding compared with other electrophilic compounds. Further, we found that isomers of simple ortho- and para-hydroquinones such as 2-methylhydroquinone (para-) and 4-methyl-catechol (ortho-) [not in abstract

New Insight into Nuclear Reactions in Solids

NASA Astrophysics Data System (ADS)

Miley, George H.

2003-04-01

Earlier work by the author disclosed evidence for nuclear transmutations in multi-layer thin-film Ni/Pd electrodes loaded to a high ratio of hydrogen/film metal using an electrolytic technique [1]. Non-natural isotopes abundances were found for select products. A distinctive characteristic of this and similar experiments by others is a product yield curve vs. mass with four high yield peaks distributed between low and high masses. Attempts to explain this observation have evolved around the original swimming electron layer (SEL) theory [2]. In addition, CR-39 track detector measurements have revealed low-level emission of 1.6 MeV protons and 16 MeV alpha particles from the front face of the thin film electrodes during runs [3]. Most recently Mitsubishi Corp. researchers have reported a real-time transmutation measurement using built-in XPS diagnostics where a surface layer of Sr-88 was transmuted into Mo-96 over a 200 hour run period during the diffusion of deuterium through a multi-layer thin-film Pd/CaO substrate [4]. Likewise in a companion experiment, Cs-133 was transmuted into Pr-141. These products exhibit a large deviation from natural isotopic abundance, and the characteristic signature is a mass change of 8 and charge change of 4. These various phenomena along with a preliminary theory involving SEL and orbital mixing will be presented. The objective is to provide a unified understanding of both types of experiments presented in Refs. 1 and 3. [1] G.H. Miley and J. A. Patterson, "Nuclear Transmutations in Thin-Film Nickel Coatings Undergoing Electrolysis," J. New Energy, 1, 3, 5-30 (1996). [2] H. Hora, et al., "Screening in Cold Fusion Derived from D D Reactions," Physics Ltrs. A, 175, 138-143, (1993). [3] A. Lipson, et al., "In-situ long - range alpha particles and X-ray detection in Pd thin film-cathodes during electrolysis in, Li2SO4/H2O, Bult. APS, 47, 1,Pt. II, 1219, Indianapolis, (2002). [4] Y. Iwamura, T. Itoh, et al., "Low energy nuclear reaction

CALL FOR PAPERS: Special cluster issue on `Experimental studies of zonal flow and turbulence'

NASA Astrophysics Data System (ADS)

Itoh, S.-I.

2005-07-01

Plasma Physics and Controlled Fusion (PPCF) invites submissions on the topic of `Experimental studies of zonal flow and turbulence', for consideration for a special topical cluster of articles to be published early in 2006. The topical cluster will be published in an issue of PPCF, combined with regular articles. The Guest Editor for the special cluster will be S-I Itoh, Kyushu University, Japan. There has been remarkable progress in the area of structure formation by turbulence. One of the highlights has been the physics of zonal flow and drift wave turbulence in toroidal plasmas. Extensive theoretical as well as computational studies have revealed the various mechanisms in turbulence and zonal flows. At the same time, experimental research on the zonal flow, geodesic acoustic modes and generation of global electric field by turbulence has evolved rapidly. Fast growth in reports of experimental results has stimulated further efforts to develop increased knowledge and systematic understanding. Each paper considered for the special cluster should describe the present research status and new scientific knowledge/results from the authors on experimental studies of zonal flow, geodesic acoustic modes and generation of electric field by turbulence (including studies of Reynolds-Maxwell stresses, etc). Manuscripts submitted to this special cluster in Plasma Physics and Controlled Fusion will be refereed according to the normal criteria and procedures of the journal. The Guest Editor guides the progress of the cluster from the initial open call, through the standard refereeing process, to publication. To be considered for inclusion in the special cluster, articles must be submitted by 2 September 2005 and must clearly state `for inclusion in the Turbulent Plasma Cluster'. Articles submitted after this deadline may not be included in the cluster issue but may be published in a later issue of the journal. Please submit your manuscript electronically via our web site at www

PREFACE: The 16th International Symposium on Boron, Borides and Related Materials (ISBB 2008)

NASA Astrophysics Data System (ADS)

Tanaka, Takaho

2009-07-01

supported by Tokyo University of Science, Suwa and foundations including, the Kajima Foundation, Foundation for Promotion of Material Science and Technology of Japan and Nippon Sheet Glass Foundation for Materials Science and Engineering, as well as companies including JFE Steel Corporation, Shincron Co, Ltd, Toyo Kohan Co, Ltd, Fukuda Metal Foil and Powder Co, Ltd, Japan New Metals Co, Ltd, H C Starck Ltd and Fritsch Japan Co, Ltd. Editors Chair Takaho Tanaka (National Institute for Materials Science, Japan) Vice chairs Koun Shirai (Osaka University, Japan) Kaoru Kimura (The University of Tokyo, Japan) Ken-ichi Takagi (Tokyo City University, Japan) Touetsu Shishido (Tohoku University, Japan) Shigeru Okada (Kokushikan University) Hideaki Itoh (Nagoya University,Japan) Katsumitsu Nakamura (Nihon University, Japan) Organizing committee of ISBB 2008 K Takagi Chairman (Tokyo City University) T Tanaka Program Committee Chairman (National Institute for Materials Science) K Kimura Secretary (The University of Tokyo) J Akimitsu (Aoyama University)K Shirai (Osaka University) H Itoh (Nagoya University)T Shishido (Tohoku University) K Nakamura (Nihon University)K Soga (Tokyo University of Science) K Nishiyama (Tokyo University of Science, Suwa)M Takeda (Nagaoka University of Technology) S Okada (Kokushikan University)Y Yamazaki (Toyo Kohan Co, Ltd) International Scientific Committee 0f ISBB (2008-2011) K Takagi Chairman (Japan) B Albert (Germany) J-F Halet (France) M Takeda (Japan) M Antadze (Georgia) H Hillebrecht (Germany) T Tanaka (Japan) J Bauer (France) W Jung (Germany) R Telle (Germany) I Boustani (Germany) K Kimura (Japan) M Trenary (USA) D Emin (USA) T Mori (Japan) O Tsagareishvili (Georgia) M Engler (Germany) P D Ownby (USA) H Werheit (Germany) N Frage (Israel) P Rogl (Austria) G Will (Germany) Yu Grin (Germany) S Shalamberidze (Georgia) O Yucel (Turkey) V N Gurin (Russia) N Shitsevalova (Ukraine) G Zhang (China)

PREFACE: 19th International Conference on the Application of High Magnetic Fields in Semiconductor Physics and Nanotechnology (HMF-19)

NASA Astrophysics Data System (ADS)

Muraki, Koji; Takeyama, Shojiro

2011-12-01

) Local Organizing Committee Chair: K Oto(Chiba Univ.) Y H Matsuda (ISSP-UT) H Yokoi (Kumamoto Univ.) M Itoh (IIS-UT) M Noda (ISSP-UT) H Sawabe (ISSP-UT) Sponsors Horiba International Conference (Dr Masao Horiba's Donation) The University of Tokyo Fukuoka City The Institute for Solid State Physics, The University of Tokyo The Global Center of Excellence for Physical Sciences Frontier, The University of Tokyo

The Deep Carbon Cycle and CO2 Sequestration

NASA Astrophysics Data System (ADS)

Filipovitch, N. B.; Mao, W. L.; Chou, I.; Mu, K.

2009-12-01

.G., Gormley, Deirdre, Nunez, Ryan, Carpenter, R.W., Squires, Kyle, Wolf, George, 2006, Carbon Sequestration via Aqueous Olivine Mineral Carbonation: Role of Passivating Layer Formation, Environ. Sci. Technol., Vol. 40, pp 4802-4808 3. Wolf, George H., Chizmeshya, Andrew V. G., Diefenbacher, Jason, McKelvy, Michael J., 2004, In Situ Observation of CO2 Sequestration Reactions Using a Novel Microreaction System, Environmental Science & Technology, Vol.38, No.3, pp 932-936 4. O’Connor, W. K., Dahlin, D. C., Nilsen, D.N., Rush, G.E., Walters, R.P., and Turner, P. C., 2000, “CO2 Storage in Solid Form: A Study of Direct Mineral Carbonation,” Proc. of the 5th International Conference on Greenhouse Gas Technologies, Cairns, Australia, August 14-18, pp. 1-7 5. Isshiki, Maiko, Irifune, Tetsuo, Hirose, Kei, Ono, Shigeaki, Ohishi, Yasuo, Watanuki, Tetsu, Nishibori, Eiji, Takata, Masaki, Sakata, Makoto, 2004, Stability of magnesite and its high-pressure form in the lowermost mantle, Nature, Vol. 427, pp. 60-63 6. Kawano, Jun, Miyake, Akira, Shimobayashi, Norimasa, Kitamura, Masao, 2009, Molecular dynamics simulation of the phase transition between calcite and CaCO3-II , Journal of Physics: Condensed Matter, Vol. 21, pp. 1-11

Origins of chromite and magnetite in sedimentary rocks deposited in a shallow water environment in the 3.2 Ga Moodies Group, South Africa

NASA Astrophysics Data System (ADS)

Otake, T.; Sakamoto, Y.; Itoh, S.; Yurimoto, H.; Kakegawa, T.

2012-12-01

*Otake, T. totake@eng.hokudai.ac.jp Div. of Sustainable Resources Engineering, Hokkaido Univ., Sapporo, Japan Sakamoto, Y. yu.sakamoto12@gmail.com Dep. of Earth Science, Tohoku Univ., Sendai, Japan Itoh, S. sitoh@ep.sci.hokudai.ac.jp Dep. of Natural History Sciences, Hokkaido Univ., Sapporo, Japan Yurimoto. H. yuri@ep.sci.hokudai.ac.jp Dep. of Natural History Sciences, Hokkaido Univ., Sapporo, Japan Kakegawa, T. kakegawa@m.tohoku.ac.jp Dep. of Earth Science, Tohoku Univ., Sendai, Japan Geochemical data from ferruginous chemical sedimentary rocks (e.g., Banded Iron Formation: BIF) have been used to reconstruct the surface environments of early Earth. However, only a few studies have investigated the geochemical characteristics of BIFs deposited in a shallow water environment during the Archean, which may have differed from those deposited in a deep water environment. Therefore, we investigated geological, petrographic and geochemical characteristics of ferruginous rocks deposited in a shallow water environment in the Moodies group, in the Barberton Greenstone Belt, South Africa. We obtained ferruginous rock samples in the Moodies group from both an outcrop and underground gold mine, and compared the characteristics of these samples. The 70 sedimentary rock samples were divided into groups based on the dominant Fe minerals they contain: Hematite-rich jaspilite (HM group), Magnetite-rich iron formation/shale/sandstone (MT group), and Siderite-rich sandstone (SD group). Samples in the HM group are predominantly composed of fine-grained quartz (< 20 μm) and hematite (< 5 μm), which are interpreted to be chemical precipitates. Samples in the MT group contain quartz, magnetite, siderite, ankerite, chlorite, biotite and chromite. The grain size of magnetite is much larger (20-150 μm) than that of hematite in the HM group. The magnetite is interpreted as a secondary mineral transformed from hematite during early diagenesis. Results of in situ oxygen isotope analysis by

A search for near-infrared molecular hydrogen emission in the CTTS LkHα 264 and the debris disk 49 Ceti

NASA Astrophysics Data System (ADS)

Carmona, A.; van den Ancker, M. E.; Henning, Th.; Goto, M.; Fedele, D.; Stecklum, B.

2007-12-01

We report on the first results of a search for molecular hydrogen emission from protoplanetary disks using CRIRES, ESO's new VLT Adaptive Optics high resolution near-infrared spectrograph. We observed the classical T Tauri star LkHα 264 and the debris disk 49 Cet, and searched for υ= 1-0 S(1) H2 emission at 2.1218 μm, υ = 1-0 S(0) H2 emission at 2.2233 μm and υ = 2-1 S(1) H2 emission at 2.2477 μm. The H2 line at 2.1218 μm is detected in LkHα 264 confirming the previous observations by Itoh et al. (2003). In addition, our CRIRES spectra reveal the previously observed but not detected H2 line at 2.2233 μm in LkHα 264. An upper limit of 5.3 × 10-16 erg s-1 cm-2 on the υ = 2-1 S(1) H2 line flux in LkHα 264 is derived. The detected lines coincide with the rest velocity of LkHα 264. They have a FWHM of ~20 km s-1. This is strongly suggestive of a disk origin for the lines. These observations are the first simultaneous detection of υ = 1-0 S(1) and υ = 1-0 S(0) H2 emission from a protoplanetary disk. 49 Cet does not exhibit H2 emission in any of the three observed lines. We derive the mass of optically thin H2 at T˜1500 K in the inner disk of LkHα 264 and derive stringent limits in the case of 49 Cet at the same temperature. There are a few lunar masses of optically thin hot H2 in the inner disk (~0.1 AU) of LkHα 264, and less than a tenth of a lunar mass of hot H2 in the inner disk of 49 Cet. The measured 1-0 S(0)/1-0 S(1) and 2-1 S(1)/1-0 S(1) line ratios in LkHα 264 indicate that the H2 emitting gas is at a temperature lower than 1500 K and that the H2 is most likely thermally excited by UV photons. The υ = 1-0 S(1) H2 line in LkHα 264 is single peaked and spatially unresolved. Modeling of the shape of the line suggests that the disk should be seen close to face-on (i<35°) and that the line is emitted within a few AU of the LkHα 264 disk. A comparative analysis of the physical properties of classical T Tauri stars in which the H2 υ = 1-0 S(1

EDITORIAL 37th European Physical Society Conference on Plasma Physics 37th European Physical Society Conference on Plasma Physics

NASA Astrophysics Data System (ADS)

Mendonça, Tito; Hidalgo, Carlos

2010-12-01

gyrokinetic code that could modify the characteristics of the turbulence. Emeric Falize and Bérénice Loupias for their investigation of similarities between laser-induced plasmas and astrophysical systems and for the description of a set of diagnostics for laser plasmas aimed at demonstrating the possible astrophysics character of plasma jets in laser-induced plasma formation. Peter Manz for his comprehensive analysis of turbulence in magnetized plasmas, exploring the interplay between flows, electric fields and fluctuations. Itoh Project Prize in Plasma Turbulence 2010 Professor Sanae Itoh from Kyushu University continued to sponsor the Itoh Project Prize in Plasma Turbulence. The 2010 prize was awarded to G Birkenmeier (Stuttgart University). IOP Poster Prize winners in Dublin, 2010. The Institute of Physics (IOP) has once again provided encouragement for young physiscs with the IOP Poster Prize. Caroline Wilkinson presented the awards this year to three candidates: Mattia Albergante (EPFL, Lausanne), Clelia Pagano (Trinity College Dublin) and Marija Vranic (Instituto Superior Tecnico, Lisbon). Proceedings of 37th EPS Conference on Plasma Physics As previously mentioned, this special issue contains the invited papers of the 37th Conference, held in 2010. The complete proceedings are available online at http://ocs.ciemat.es/EPS2010PAP/html/ This site is also accessible from the conference website at http://www.eps2010.com/ (under `Contributions'). The Local Organizing Committee has also prepared a CD with a copy of the proceedings, identical to the online proceedings. This CD is stored at the offices of the European Physical Society as a backup, and as a master copy to make additional copies in case anyone should require one.

Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

PubMed

Donnelly, Alison; Blagg, Brian S J

2008-01-01

proteins. Unlike the N-terminal ATP binding site, there is no reported co-crystal structure of Hsp90 C-terminus bound to any inhibitor. The Hsp90 C-terminal domain, however, is known to contain a conserved pentapeptide sequence (MEEVD) which is recognized by co-chaperones. Cisplatin is a platinum-containing chemotherapeutic used to treat various types of cancers, including testicular, ovarian, bladder, and small cell lung cancer. Most notably, cisplatin coordinates to DNA bases, resulting in cross-linked DNA, which prohibits rapidly dividing cells from duplicating DNA for mitosis. Itoh and co-workers reported that cisplatin decreases the chaperone activity of Hsp90. This group applied bovine brain cytosol to a cisplatin affinity column, eluted with cisplatin and detected Hsp90 in the eluent. Subsequent experiments indicated that cisplatin exhibits high affinity for Hsp90. Moreover Csermely and co-workers determined that the cisplatin binding site is located proximal to the C-terminal ATP binding site. EGCG is one of the active ingredients found in green tea. EGCG is known to inhibit the activity of many Hsp90-dependent client proteins, including telomerase, several kinases, and the aryl hydrocarbon receptor (AhR). Recently Gasiewicz and co-workers reported that EGCG manifests its antagonistic activity against AhR through binding Hsp90. Similar to novobiocin, EGCG was shown to bind the C-terminus of Hsp90. Unlike previously identified N-terminal Hsp90 inhibitors, EGCG does not appear to prevent Hsp90 from forming multiprotein complexes. Studies are currently underway to determine whether EGCG competes with novobiocin or cisplatin binding. Taxol, a well-known drug for the treatment of cancer, is responsible for the stabilization of microtubules and the inhibition of mitosis. Previous studies have shown that taxol induces the activation of kinases and transcription factors, and mimics the effect of bacterial lipopolysaccharide (LPS), an attribute unrelated to its tubulin

PREFACE: 11th IAEA Technical Meeting on H-mode Physics and Transport Barriers

NASA Astrophysics Data System (ADS)

Takizuka, Tomonori

2008-07-01

(University of Tsukuba, Japan) K Itoh (National Institute for Fusion Science, Japan) S-I Itoh (Kyushu University, Japan) F Jenko (Max-Plank-Institut für Plasmaphysik, Germany) D Kalupin (Institut für Plasmaphysik, Forschungszentrum Jülich GmbH, Germany) Y Kamada (Japan Atomic Energy Agency, Japan) N Kasuya (National Institute for Fusion Science, Japan) I Katanuma (University of Tsukuba, Japan) M Kimura (Kyushu University, Japan) A Kirk (EURATOM/UKAEA Fusion Association, UK) S Kitajima (Tohoku University, Japan) S Kobayashi (Kyoto University, Japan) T Kobuchi (Tohoku University, Japan) J Kohagura (University of Tsukuba, Japan) P T Lang (Max-Plank-Institut für Plasmaphysik, Germany) S V Lebedev (Ioffe Institute, Russia) A W Leonard (General Atomics, USA) J Q Li (Kyoto University, Japan) A Malaquias (International Atomic Energy Agency) Y R Martin (Centre de Recherches en Physique des Plasmas, EPFL, Switzerland) C J McDevitt (University of California, San Diego, USA) D C McDonald (EURATOM/UKAEA Fusion Association, UK) H Meyer (EURATOM/UKAEA Fusion Association, UK) C A Michael (National Institute for Fusion Science, Japan) K Miki (Kyushu University, Japan) R Minami (University of Tsukuba, Japan) T Minami (National Institute for Fusion Science, Japan) Y Miyata (University of Tsukuba, Japan) N Miyato (Japan Atomic Energy Agency, Japan) Y Motegi (University of Tsukuba, Japan) V Mukhovatov (ITER Organization) S Murakami (Kyoto University, Japan) Y Nagashima (Kyushu University, Japan) Y Nakashima (University of Tsukuba, Japan) T Numakura (University of Tsukuba, Japan) S Ohshima (National Institute for Fusion Science, Japan) T Oishi (National Institute for Fusion Science, Japan) T Onjun (Sirindhorn International Institute of Technology, Thailand) T H Osborne (GENERAL Atomics, USA) N Oyama (Japan Atomic Energy Agency, Japan) T Ozeki (Japan Atomic Energy Agency, Japan) V Parail (EURATOM/UKAEA Fusion Association, UK) A Polevoi (ITER Organization, France) J E Rice (MIT Plasma Science

PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2010)

NASA Astrophysics Data System (ADS)

Lin, Simon C.; Shen, Stella; Neufeld, Niko; Gutsche, Oliver; Cattaneo, Marco; Fisk, Ian; Panzer-Steindel, Bernd; Di Meglio, Alberto; Lokajicek, Milos

2011-12-01

, as well as two banquets held at the Grand Hotel and Grand Formosa Regent in Taipei. The next CHEP conference will be held in New York, the United States on 21-25 May 2012. We would like to thank the National Science Council of Taiwan, the EU ACEOLE project, commercial sponsors, and the International Advisory Committee and the Programme Committee members for all their support and help. Special thanks to the Programme Committee members for their careful choice of conference contributions and enormous effort in reviewing and editing about 340 post conference proceedings papers. Simon C Lin CHEP 2010 Conference Chair and Proceedings Editor Taipei, Taiwan November 2011 Track Editors/ Programme Committee Chair Simon C Lin, Academia Sinica, Taiwan Online Computing Track Y H Chang, National Central University, Taiwan Harry Cheung, Fermilab, USA Niko Neufeld, CERN, Switzerland Event Processing Track Fabio Cossutti, INFN Trieste, Italy Oliver Gutsche, Fermilab, USA Ryosuke Itoh, KEK, Japan Software Engineering, Data Stores, and Databases Track Marco Cattaneo, CERN, Switzerland Gang Chen, Chinese Academy of Sciences, China Stefan Roiser, CERN, Switzerland Distributed Processing and Analysis Track Kai-Feng Chen, National Taiwan University, Taiwan Ulrik Egede, Imperial College London, UK Ian Fisk, Fermilab, USA Fons Rademakers, CERN, Switzerland Torre Wenaus, BNL, USA Computing Fabrics and Networking Technologies Track Harvey Newman, Caltech, USA Bernd Panzer-Steindel, CERN, Switzerland Antonio Wong, BNL, USA Ian Fisk, Fermilab, USA Niko Neufeld, CERN, Switzerland Grid and Cloud Middleware Track Alberto Di Meglio, CERN, Switzerland Markus Schulz, CERN, Switzerland Collaborative Tools Track Joao Correia Fernandes, CERN, Switzerland Philippe Galvez, Caltech, USA Milos Lokajicek, FZU Prague, Czech Republic International Advisory Committee Chair: Simon C. Lin , Academia Sinica, Taiwan Members: Mohammad Al-Turany , FAIR, Germany Sunanda Banerjee, Fermilab, USA Dario Barberis, CERN

PREFACE: Tenth International Conference on Topics in Astroparticle and Underground Physics (TAUP2007)

NASA Astrophysics Data System (ADS)

Inoue, Kunio; Suzuki, Atsuto; Mitsui, Tadao

2008-07-01

Otsuka, and Ms Yuri Endo, our workshop secretaries, for their continuous and excellent work in the organization of the conference, and to Ms Chiyo Itoh, and Ms Machiko Mizutani, for their invaluable assistance during the conference. We also gratefully thank the technical staff: Tomoaki Takayama, Hiromitsu Hanada, Takashi Nakajima, for their invaluable help. As announced at the end of the conference, TAUP 2009 will be held in Gran Sasso, Italy, hosted by the Istituto Nazionale di Fisica Nucleare (INFN) with the chair of Professor Eugenio Coccia. Kunio Inoue, Atsuto Suzuki and Tadao Mitsui COMMITTEES TAUP Steering Committee F T Avignone U South Carolina B C Barish CALTECH E Bellotti U Milano/INFN J Bernabéu U Valencia A Bottino (chair) U Torino/INFN V de Alfaro U Torino/INFN T Kajita ICRR U Tokyo C W Kim Johns Hopkins Univ /KIAS E Lorenz U München V Matveev INR Moskow J Morales U Zaragoza D Sinclair U Carleton M Spiro IN2P3 TAUP 2007 International Advisory Committee J J Aubert CNRS Marseille M Baldo-Ceolin U Padova/INFN V Berezinsky INFN-LNGS/INR L Bergström U Stockholm R Bernabei U Roma Tor Vergata/INFN A Bettini U Padova/INFN S Bilenky JINR Dubna D O Caldwell U C Santa Barbara E Coccia INFN-LNGS/U Roma Tor Vergata J Cronin U Chicago A Dar Technion Haifa G Domogatsky INR Moscow H Ejiri U Osaka J Ellis CERN E Fernández IFAE Barcelona E Fiorini U Milano/INFN G Fogli U Bari/INFN T Gaisser U Delaware G Gelmini UCLA G Gerbier CEA Saclay F Halzen U Wisconsin W Haxton U Washington T Kirsten MPI Heidelberg L Maiani U Roma/INFN A McDonald Queen's U K Nakamura KEK E Peterson U Minneapolis R Petronzio INFN/U Roma Tor Vergata G Raffelt MPI München R Rebolo IAC Tenerife L Resvanis U Athens P Salati U Savoie/LAPTH Annecy A Smirnov ICTP Trieste N Spooner U Sheffield S Ting MIT/CERN Y Totsuka U Tokyo M S Turner FNAL/U Chicago J W F Valle IFIC Valencia D Vignaud APC Paris F von Feilitzsch T U München G Zatsepin INR Moscow TAUP 2007 Organizing Committee A Bottino U Torino/INFN D

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide-binding Pocket

PubMed Central

Donnelly, Alison; Blagg, Brian S. J.

2009-01-01

N-terminal ATP binding site, there is no reported co-crystal structure of Hsp90 C-terminus bound to any inhibitor. The Hsp90 C-terminal domain, however, is known to contain a conserved pentapeptide sequence (MEEVD) which is recognized by co-chaperones. Cisplatin is a platinum-containing chemotherapeutic used to treat various types of cancers, including testicular, ovarian, bladder, and small cell lung cancer. Most notably, cisplatin coordinates to DNA bases, resulting in cross-linked DNA, which prohibits rapidly dividing cells from duplicating DNA for mitosis. Itoh and co-workers reported that cisplatin decreases the chaperone activity of Hsp90. This group applied bovine brain cytosol to a cisplatin affinity column, eluted with cisplatin and detected Hsp90 in the eluent. Subsequent experiments indicated that cisplatin exhibits high affinity for Hsp90. Moreover Csermely and co-workers determined that the cisplatin binding site is located proximal to the C-terminal ATP binding site. EGCG is one of the active ingredients found in green tea EGCG is known to inhibit the activity of many Hsp90-dependent client proteins, including telomerase, several kinases, and the aryl hydrocarbon receptor (AhR). Recently Gasiewicz and co-workers reported that EGCG manifests its antagonistic activity against AhR through binding Hsp90. Similar to novobiocin, EGCG was shown to bind the C-terminus of Hsp90. Unlike previously identified N-terminal Hsp90 inhibitors, EGCG does not appear to prevent Hsp90 from forming multiprotein complexes. Studies are currently underway to determine whether EGCG competes with novobiocin or cisplatin binding. Taxol, a well-known drug for the treatment of cancer, is responsible for the stabilization of microtubules and the inhibition of mitosis. Previous studies have shown that taxol induces the activation of kinases and transcription factors, and mimies the effect of bacterial lipopolysaccharide (LPS), an attribute unrelated to its tubulin-binding properties

PREFACE: Exploring surfaces and buried interfaces of functional materials by advanced x-ray and neutron techniques Exploring surfaces and buried interfaces of functional materials by advanced x-ray and neutron techniques

NASA Astrophysics Data System (ADS)

Sakurai, Kenji

2010-12-01

measurement. Advances in such technologies are bringing with them new opportunities in surface and buried interface science. In the not too distant future, we will publish a special issue or a book detailing such progress. Exploring surfaces and buried interfaces of functional materials by advanced x-ray and neutron techniques contents Lateral uniformity in chemical composition along a buried reaction front in polymers using off-specular reflectivity Kristopher A Lavery, Vivek M Prabhu, Sushil Satija and Wen-li Wu Orientation dependence of Pd growth on Au electrode surfaces M Takahasi, K Tamura, J Mizuki, T Kondo and K Uosaki A grazing incidence small-angle x-ray scattering analysis on capped Ge nanodots in layer structures Hiroshi Okuda, Masayuki Kato, Keiji Kuno, Shojiro Ochiai, Noritaka Usami, Kazuo Nakajima and Osami Sakata High resolution grazing-incidence in-plane x-ray diffraction for measuring the strain of a Si thin layer Kazuhiko Omote X-ray analysis of mesoporous silica thin films templated by Brij58 surfactant S Fall, M Kulij and A Gibaud Review of the applications of x-ray refraction and the x-ray waveguide phenomenon to estimation of film structures Kouichi Hayashi Epitaxial growth of largely mismatched crystals on H-terminated Si(111) surfaces Hidehito Asaoka Novel TiO2/ZnO multilayer mirrors at 'water-window' wavelengths fabricated by atomic layer epitaxy H Kumagai, Y Tanaka, M Murata, Y Masuda and T Shinagawa Depth-selective structural analysis of thin films using total-external-reflection x-ray diffraction Tomoaki Kawamura and Hiroo Omi Structures of Yb nanoparticle thin films grown by deposition in He and N2 gas atmospheres: AFM and x-ray reflectivity studies Martin Jerab and Kenji Sakurai Ga and As composition profiles in InP/GaInAs/InP heterostructures—x-ray CTR scattering and cross-sectional STM measurements Yoshikazu Takeda, Masao Tabuchi and Arao Nakamura Polarized neutron reflectivity study of a thermally treated MnIr/CoFe exchange bias system Naoki

[Lessons learned from tuberculosis outbreak cases].

PubMed

Kato, Seiya; Kuwabara, Katsuhiro

2014-02-01

Teishin Hospital), Toru MORI (Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association) The index case was a patient who was admitted to a general hospital where she was treated with pulsed corticosteroid therapy and then put on a respirator. Soon after, she developed tuberculosis (TB) and died. Immediately after her death, the healthcare workers who had close contact with the index case were given the QuantiFERON TB Gold (QFT) test, which indicated that all staff except one were negative. However, a QFT test administered eight weeks later had a positive rate of 18.6%. Subsequently, a total of five workers, including a doctor, nurses, and radiology technicians, developed TB. The bacterial isolates from five of them exhibited an RFLP pattern identical to that of the index case. These secondary cases of TB included a case who had contact of less than 5 minutes, a case whose QFT was negative ("doubtful" in the Japanese criterion of the QFT), and a case who was QFT-positive but declined to be treated for latent TB infection (LTBI). No other workers nor hospitalized patients developed TB. The healthcare worker contacts were further examined with the QFT 6, 9 and 12 months after the contact. The QFT results revealed four additional positive reactors and four "doubtful" reactors who were indicated for LTBI treatment. Among them were seven subjects who turned positive six months after the contact. TB prevention in hospital settings and contact investigations were discussed with the hospital staff, with special reference to the application of QFT. 3. Summary and issues of concern relating to a tuberculosis outbreak in a prison: Mitsunobu HOMMA, Takefumi ITOH (Department of Respiratory Medicine, Akita City Hospital) We report a tuberculosis outbreak that occurred in a prison in the spring of 2011, resulting in 11 cases of active disease and 40 cases of infection. The primary cause of the outbreak is thought to be the delay in identifying the index case, where the

Strong carbon sink of monsoon tropical seasonal forest in Southern Vietnam

NASA Astrophysics Data System (ADS)

Deshcherevskaya, Olga; Anichkin, Alexandr; Avilov, Vitaly; Duy Dinh, Ba; Luu Do, Phong; Huan Tran, Cong; Kurbatova, Julia

2014-05-01

-1, from carbon source to the strong sink. Storage total for all the year was near-zero, but in our case including of storage resulted in gap-filling regression changes with corresponding change in total carbon balance. Probably the only way for proper net carbon balance evaluation for NCT site is chamber-measurements of night respiration of different ecosystem components, as used at Pasoh EC station, Malaysia. Ciais P., Piao S.L., Cadule P., Friedlingstein P., & Chedin A. Variability and recent trends in the African carbon balance. Biogeosciences Discussions, 5(4), 2008. Pp. 3497-3532. Clark D.A. Sources or sinks? The responses of tropical forests to current and future climate and atmospheric composition. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 359(1443), 2004. Pp. 477-491. Gifford, R. M. (1994). The global carbon cycle: a viewpoint on the missing sink. Functional Plant Biology, 21(1), 1-15. Kosugi Y., Takanashi S., Tani M., Ohkubo S., Matsuo N., Itoh M., Noguchi S. & Nik A.R. Effect of inter-annual climate variability on evapotranspiration and canopy CO2 exchange of a tropical rainforest in Peninsular Malaysia. Journal of forest research, 17(3), 2012. Pp. 227-240. Malhi, Y. (2010). The carbon balance of tropical forest regions, 1990-2005. Current Opinion in Environmental Sustainability, 2(4), 237-244. Saigusa, N., Yamamoto, S., Hirata, R., Ohtani, Y., Ide, R., Asanuma, J., ... & Wang, H. (2008). Temporal and spatial variations in the seasonal patterns of CO2 flux in boreal, temperate, and tropical forests in East Asia. Agricultural and forest meteorology, 148(5), 700-713.

EDITORIAL: Message from the Editor Message from the Editor

NASA Astrophysics Data System (ADS)

Thomas, Paul

2010-02-01

November 2009 and provided particularly detailed advice to the authors. The other three have been very helpful in 'minority fields'. We have excluded our Board members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their Special Issues is also excluded from consideration. The following people have been selected: Tomonori Takizuka, JAEA-Naka Fusion Institute, Japan Rudolf Neu, Max-Planck-Institut für Plasmaphysik, Germany Sibylle Guenter, Max-Planck-Institut für Plasmaphysik, Germany Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States David R. Mikkelsen, Princeton Plasma Physics Laboratory, United States Peter C. de Vries, EURATOM/UKAEA Fusion Association, United Kingdom Yasuhiro Suzuki, National Institute for Fusion Science, Japan Jerzy Wolowski, Institute of Plasma Physics and Laser Microfusion, Poland Tetsuo Tanabe, Kyushu University, Japan Yasuyuki Yagi, National Institute of Advanced Industrial Science and Technology, Japan Congratulations and many, many thanks! The Guest Editors of special editions deserve a special mention for the excellent help that they have given us. They are: Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States, Special Issue on H-Mode Physics and Transport Barriers Yaroslav Kolesnichenko, Institute for Nuclear Research, Ukraine, Special Issue on Energetic Particles in Magnetic Confinement Systems Kimitaka Itoh, National Institute for Fusion Science, Japan and Howard R. Wilson, University of York, UK, Special Issue on Plasma Instabilities Bernhard Unterberg, Forschungszentrum Juelich, Germany, Special Issue on Stochastic Fusion Plasma In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2009. Our thanks to them! Authors The winner of the 2009 Nuclear Fusion

High energy neutrinos from astrophysical accelerators of cosmic ray nuclei

NASA Astrophysics Data System (ADS)

Anchordoqui, Luis A.; Hooper, Dan; Sarkar, Subir; Taylor, Andrew M.

2008-02-01

.1181983223S.P.LaiJ.M.GirartR.CrutcherAstrophys. J.5982003392W.BednarekMon. Not. R. Astron. Soc.3452003847W.BednarekR.J.ProtheroeAstropart. Phys.162002397P.BlasiA.V.OlintoPhys. Rev. D591999023001F.W.SteckerAstropart. Phys.262007398F.W. Stecker, arXiv:astro-ph/0610208.A γ-ray signal from the nearby starburst galaxy NGC253 was reported by the CANGAROO-II Collaboration but their subsequent re-analysis of the data is consistent with the expectation from backgrounds:C.ItohCANGAROO-II CollaborationAstron. Astrophys.3962002L1(Erratum-ibid. 462 (2007) 67)T.A. Thompson, E. Quataert, E. Waxman, A. Loeb, arXiv:astro-ph/0608699.D.J.BirdFly’s Eye CollaborationPhys. Rev. Lett.7119933401D.R.BergmanHiRes CollaborationNucl. Phys. Proc. Suppl.136200440T.Abu-ZayyadHiRes-MIA CollaborationAstrophys. J.5572001686M.NaganoJ. Phys. G181992423V.BerezinskyA.Z.GazizovS.I.GrigorievaPhys. Rev. D742006043005R.U.AbbasiHiRes CollaborationPhys. Rev. Lett.922004151101V.BerezinskyA.Z.GazizovS.I.GrigorievaPhys. Lett. B6122005147V.S.BerezinskyS.I.GrigorievaB.I.HnatykAstropart. Phys.212004617See Fig. 21 in:L.AnchordoquiM.T.DovaA.MariazziT.McCauleyT.PaulS.ReucroftJ.SwainAnn. Phys.3142004145D.AllardE.ParizotE.KhanS.GorielyA.V.OlintoAstron. Astrophys.4432005L29D.AllardE.ParizotA.V.OlintoAstropart. Phys.27200761T.Abu-ZayyadHigh Resolution Fly’s Eye CollaborationAstropart. Phys.232005157P. Sommers, et al., Pierre Auger Collaboration, arXiv:astro-ph/0507150.R.U.AbbasiHiRes CollaborationAstrophys. J.6222005910B.N. Afanasiev, et al., Yakutsk Collaboration, in: M. Nagano (Ed.), Proceedings of the Tokyo Workshop on Techniques for the Study of the Extremely High Energy Cosmic Rays, 1993.J. Knapp, private communication.J.RanftPhys. Rev. D51199564R.S.FletcherT.K.GaisserP.LipariT.StanevPhys. Rev. D5019945710J.EngelT.K.GaisserT.StanevP.LipariPhys. Rev. D4619925013N.N.KalmykovS.S.OstapchenkoA.I.PavlovNucl. Phys. Proc. Suppl.52B19977It is important to stress that the Auger data are still at a preliminary stage and the