Computational Thermodynamics of Materials Zi-Kui Liu and Yi Wang

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devanathan, Ram

This authoritative volume introduces the reader to computational thermodynamics and the use of this approach to the design of material properties by tailoring the chemical composition. The text covers applications of this approach, introduces the relevant computational codes, and offers exercises at the end of each chapter. The book has nine chapters and two appendices that provide background material on computer codes. Chapter 1 covers the first and second laws of thermodynamics, introduces the spinodal as the limit of stability, and presents the Gibbs-Duhem equation. Chapter 2 focuses on the Gibbs energy function. Starting with a homogeneous system with amore » single phase, the authors proceed to phases with variable compositions, and polymer blends. The discussion includes the contributions of external electric and magnetic fields to the Gibbs energy. Chapter 3 deals with phase equilibria in heterogeneous systems, the Gibbs phase rule, and phase diagrams. Chapter 4 briefly covers experimental measurements of thermodynamic properties used as input for thermodynamic modeling by Calculation of Phase Diagrams (CALPHAD). Chapter 5 discusses the use of density functional theory to obtain thermochemical data and fill gaps where experimental data is missing. The reader is introduced to the Vienna Ab Initio Simulation Package (VASP) for density functional theory and the YPHON code for phonon calculations. Chapter 6 introduces the modeling of Gibbs energy of phases with the CALPHAD method. Chapter 7 deals with chemical reactions and the Ellingham diagram for metal-oxide systems and presents the calculation of the maximum reaction rate from equilibrium thermodynamics. Chapter 8 is devoted to electrochemical reactions and Pourbaix diagrams with application examples. Chapter 9 concludes this volume with the application of a model of multiple microstates to Ce and Fe3Pt. CALPHAD modeling is briefly discussed in the context of genomics of materials. The book introduces basic thermodynamic concepts clearly and directs readers to appropriate references for advanced concepts and details of software implementation. The list of references is quite comprehensive. The authors make liberal use of diagrams to illustrate key concepts. The two Appendices at the end discuss software requirements and the file structure, and present templates for special quasi-random structures. There is also a link to download pre-compiled binary files of the YPHON code for Linux or Microsoft Windows systems. The exercises at the end of the chapters assume that the reader has access to VASP, which is not freeware. Readers without access to this code can work on a limited number of exercises. However, results from other first principles codes can be organized in the YPHON format as explained in the Appendix. This book will serve as an excellent reference on computational thermodynamics and the exercises provided at the end of each chapter make it valuable as a graduate level textbook. Reviewer: Ram Devanathan is Acting Director of Earth Systems Science Division, Pacific Northwest National Laboratory, USA.« less

Occupational IgE-mediated asthma, rhinoconjunctivitis, and contact urticaria caused by Easter lily (Lilium longiflorum) and tulip.

PubMed

Piirilä, P; Kanerva, L; Alanko, K; Estlander, T; Keskinen, H; Pajari-Backas, M; Tuppurainen, M

1999-03-01

We report on IgE-mediated asthma, rhinoconjunctivitis, and contact urticaria to two Liliaceae plants, tulip and Easter lily (Lilium longiflorum), diagnosed in a floral shop worker. Occupational asthma was diagnosed according to patient history, PEF monitoring, and a work-simulating provocation test. Flower-specific IgE was studied, and RAST inhibition tests were performed. Skin prick testing showed positive reactions to tulip, Easter lily, and chrysanthemum. Total IgE was 180 kU/I, and specific IgE to tulip was 2.6 and to Easter lily 6.5 kU/I. In the RAST-inhibition test, no cross-reactivity was found. Occupational asthma was diagnosed by peak flow monitoring at work and at home, as well as specific inhalation challenge with Easter lily, with an immediate 18% reduction in PEF. In addition, contact urticaria and conjunctivitis were diagnosed. After a 9-year follow-up without exposure to lilies, the skin prick tests to L. longiflorum and tulip were still positive, but the specific IgE had disappeared. A case of IgE-mediated occupational asthma, rhinoconjunctivitis, and contact urticaria caused by L. longiflorum and tulip is presented. RAST inhibition tests indicated concomitant sensitization to the two Liliaceae plants.

Interaction of Anti-G Measures and Chest Wall Mechanics in Determining Gas Exchange.

DTIC Science & Technology

1983-06-01

ADDRESS 10. PROGRAM EL.EMENT. PROJECT. TASK ILn Virginia Mason Research Center AE 7 KUI UBR IV 1000 Seneca Street t-? / TIM Seattle, Washington 98101...13. NUMBER:Z:- PAGES 14. MONITORING AGENCY NAME 6 ADDRESS(itdifferent from Controlling Office) 15S SECURIT. = LAS (-([,A&W report) 15a. DECLAS...pulmonary vascular resistance de - suring the small pressure difference between the bottom pends on smooth muscle tone in resistance vessels, but, of the

Work-family conflict and self-rated health among Japanese workers: How household income modifies associations.

PubMed

Kobayashi, Tomoko; Honjo, Kaori; Eshak, Ehab Salah; Iso, Hiroyasu; Sawada, Norie; Tsugane, Shoichiro

2017-01-01

To examine associations between work-family conflict and self-rated health among Japanese workers and to determine whether the associations differed by household income. Data was derived from the Japan Public Health Center-based Prospective Study for the Next Generation in Saku area in 2011-2012 (7,663 men and 7,070 women). Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for poor self-rated health by work-family conflict consisting of two dimensions (work-to-family and family-to-work conflicts) were calculated by gender and household income. Multivariate ORs of high work-to-family and family-to-work conflicts for poor self-rated health were 2.46 (95% CI; 2.04-2.97) for men and 3.54 (95% CI; 2.92-4.30) for women, with reference to the low work-to-family and family-to-work conflicts (p-value for gender interaction = 0.02). Subgroup analysis indicated that health effects of work-family conflict were likely to be more evident in the low income group only among women. Work-family conflict was associated with poor self-rated health among middle-aged Japanese men and women; its health impact was relatively stronger among women, and particularly economically disadvantaged women.

Work–family conflict and self-rated health among Japanese workers: How household income modifies associations

PubMed Central

Kobayashi, Tomoko; Honjo, Kaori; Eshak, Ehab Salah; Iso, Hiroyasu; Sawada, Norie; Tsugane, Shoichiro

2017-01-01

To examine associations between work–family conflict and self-rated health among Japanese workers and to determine whether the associations differed by household income. Data was derived from the Japan Public Health Center-based Prospective Study for the Next Generation in Saku area in 2011–2012 (7,663 men and 7,070 women). Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for poor self-rated health by work–family conflict consisting of two dimensions (work-to-family and family-to-work conflicts) were calculated by gender and household income. Multivariate ORs of high work-to-family and family-to-work conflicts for poor self-rated health were 2.46 (95% CI; 2.04–2.97) for men and 3.54 (95% CI; 2.92–4.30) for women, with reference to the low work-to-family and family-to-work conflicts (p-value for gender interaction = 0.02). Subgroup analysis indicated that health effects of work–family conflict were likely to be more evident in the low income group only among women. Work–family conflict was associated with poor self-rated health among middle-aged Japanese men and women; its health impact was relatively stronger among women, and particularly economically disadvantaged women. PMID:28207757

A Structural Weight Estimation Program (SWEEP) for Aircraft. Volume III - Airloads Estimation Module. Appendix A: Module Flow Charts and FORTRAN Lists. Appendix B: Sample Output

DTIC Science & Technology

1974-06-01

COMMERCE . ■ . ..,...-: . c.. . . . .... .. . . . -. . Best Available Copy .. . . ’ . . . . ■ . «ICUWITV CCMHyiCATlOM 0’ TMII PAOC tW* m ...aircraft structural weight optimization, flutter optimization program, structural synthesis 10 ABSTRACT rCwidnu« on r«v»ft« «itf* M i Three...PAaZfVhtt Data tnffd) «cs;-W!.’i \\K »ifl • Jrflu 5/ r * i» .... ,r, M I J » i| *k\\Ui »’ PUT« « UM irr;!■ ,•’ rfra A NOTICES When

Endometrial stromal tumours revisited: an update based on the 2014 WHO classification.

PubMed

Ali, Rola H; Rouzbahman, Marjan

2015-05-01

Endometrial stromal tumours (EST) are rare tumours of endometrial stromal origin that account for less than 2% of all uterine tumours. Recent cytogenetic and molecular advances in this area have improved our understanding of ESTs and helped refine their classification into more meaningful categories. Accordingly, the newly released 2014 WHO classification system recognises four categories: endometrial stromal nodule (ESN), low-grade endometrial stromal sarcoma (LGESS), high-grade endometrial stromal sarcoma (HGESS) and undifferentiated uterine sarcoma (UUS). At the molecular level, these tumours may demonstrate a relatively simple karyotype with a defining chromosomal rearrangement (as in the majority of ESNs, LGESSs and YWHAE-rearranged HGESS) or demonstrate complex cytogenetic aberrations lacking specific rearrangements (as in UUSs). Herein we provide an update on this topic aimed at the practicing pathologist. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Selection and Evaluation of a Real Time Monitoring System for the Bigeye Bomb Fill/Close Production Facility. Phase 2

DTIC Science & Technology

1989-06-01

and ZIP Code ) 10 SOURCE OF FUNDING NU MBERS I O KUI PROGRAM PRO ECCT TASKWOKUI E L E M E N T N O . N O .I 1 2 0 N O A 5 A C C E S S I O N N OlI I1 TITLE... source of by-products formation. Generating Data for Mathematical Modeling of Real Vapor Phase Reaction Systems (tremendously speeds multi -level, multi ...SMCC-RI1 6c AD RS(Ciry,. State, and ZIP Code ) SCRRI 7b. ADDRESS (City, State, and ZIP Code ) IA!hrueýýt Proving Ground, MD 21010-54213 a.NMOFFUNI.DNG

Factors influencing users' return home on discharge from a geriatric intermediate care facility in Japan.

PubMed

Ishizaki, T; Kai, I; Hisata, M; Kobayashi, Y; Wakatsuki, K; Ohi, G

1995-06-01

To determine the factors that influence users' destinations on discharge from Geriatric Intermediate Care Facilities (GICFs), which were established in Japan in 1987 to help hospitalized older people return home. Retrospective chart review. A 94-bed GICF attached to Saku Central Hospital in Japan. Charts of all users (N = 437) aged 65 years and older, discharged from the GICF between July 1987 and February 1991, were reviewed. The independent variables, obtained from users' admission records, were age, sex, place of residence before admission, length of stay, intellectual impairment (assessed by Karasawa's diagnostic criteria for senile dementia), ability to perform activities of daily living (ADLs), and living arrangement of users in the GICF. The dependent variable was destination after discharge from the GICF. Multiple logistic regression analyses revealed that, compared with users who were able to successfully return home, users with little ability to perform ADLs, male users, and those admitted from other institutions were more likely to be hospitalized. Such analyses also revealed that users who came from institutions, had low ability to perform ADLs, and lived alone were more likely to be institutionalized in nursing homes. Evaluating a user's physical, mental, and socioeconomic conditions at an early stage of admission to a GICF may allow us to predict whether the user can be successfully discharged to his or her home or will have to remain in the GICF for an extended period.

Development of a Precipitation-Runoff Model to Simulate Unregulated Streamflow in the Salmon Creek Basin, Okanogan County, Washington

USGS Publications Warehouse

van Heeswijk, Marijke

2006-01-01

historical monthly mean unregulated streamflow based on reservoir outflows and storage changes were used as a surrogate for the missing data and to calibrate and test the model. The estimated unregulated streamflows were corrected for evaporative losses from Conconully Reservoir (about 1 ft3/s) and ground-water losses from the basin (about 2 ft3/s). The total of the corrections was about 9 percent of the mean uncorrected streamflow of 32.2 ft3/s (23,300 acre-ft/yr) for water years 1949-96. For the calibration period, the basinwide mean annual evapotranspiration was simulated to be 19.1 inches, or about 83 percent of the mean annual precipitation of 23.1 inches. Model calibration and testing indicated that the daily streamflows simulated using the precipitation-runoff model should be used only to analyze historical and forecasted annual mean and April-July mean streamflows for Salmon Creek at Conconully Dam. Because of the paucity of model input data and uncertainty in the estimated unregulated streamflows, the model is not adequately calibrated and tested to estimate monthly mean streamflows for individual months, such as during low-flow periods, or for shorter periods such as during peak flows. No data were available to test the accuracy of simulated streamflows for lower Salmon Creek. As a result, simulated streamflows for lower Salmon Creek should be used with caution. For the calibration period (water years 1950-89), both the simulated mean annual streamflow and the simulated mean April-July streamflow compared well with the estimated uncorrected unregulated streamflow (UUS) and corrected unregulated streamflow (CUS). The simulated mean annual streamflow exceeded UUS by 5.9 percent and was less than CUS by 2.7 percent. Similarly, the simulated mean April-July streamflow exceeded UUS by 1.8 percent and was less than CUS by 3.1 percent. However, streamflow was significantly undersimulated during the low-flow, baseflow-dominated months of November through F

Classrooms in the Wild: Learning Language and Life Skills in the KUIS Outdoor Sports Circle.

ERIC Educational Resources Information Center

Wurr, Adrian

The role of outdoor education activities in the Kanda University English language institute is described. The outdoor program was developed to unite faculty and students interested in recreational activities and provide an opportunity to explore common interests in nature, sports, and language learning. The activities develop self-esteem,…

Comparison of expert and nonexpert swimmers' opinions about the value, potency, and activity of four standard swimming strokes and underwater undulatory swimming.

PubMed

Collard, L; Oboeuf, A

2009-04-01

Underwater undulatory swimming (UUS) is often perceived to be a nonessential aspect of aquatic propulsion. Given their solid theoretical and practical training in swimming, physical education students should be capable of judging the true value of the "fifth stroke," since it appears to be the most efficient technique in high level, competitive swimming. To compare opinions and connotations associated with the stroke and the four official strokes (butterfly, backstroke, breaststroke, and crawl), 198 students (32 of whom were expert swimmers; M age = 20.6 yr., SD = 1.2), were surveyed using the semantic differential of Osgood, Suci, and Tannenbaum. Although answers of expert and nonexpert swimmers differed significantly (p < .01, except for the breaststroke), participants considered overall that undulatory stroke was less attractive, less powerful, and less rapid than the four surface strokes (d = 2.88 for the expert swimmers). Putting one arm in front of the other and repeating the sequence still remains the most solidly held representation of "the right way" to swim. However, the high observed standard deviations for the underwater undulatory stimulus (SD > or = 1.1 with SD max = 3 for the expert swimmers) attests to the view being less strongly held by swimming specialists.

Spin-orbit coupling calculations with the two-component normalized elimination of the small component method

NASA Astrophysics Data System (ADS)

Filatov, Michael; Zou, Wenli; Cremer, Dieter

2013-07-01

A new algorithm for the two-component Normalized Elimination of the Small Component (2cNESC) method is presented and tested in the calculation of spin-orbit (SO) splittings for a series of heavy atoms and their molecules. The 2cNESC is a Dirac-exact method that employs the exact two-component one-electron Hamiltonian and thus leads to exact Dirac SO splittings for one-electron atoms. For many-electron atoms and molecules, the effect of the two-electron SO interaction is modeled by a screened nucleus potential using effective nuclear charges as proposed by Boettger [Phys. Rev. B 62, 7809 (2000), 10.1103/PhysRevB.62.7809]. The use of the screened nucleus potential for the two-electron SO interaction leads to accurate spinor energy splittings, for which the deviations from the accurate Dirac Fock-Coulomb values are on the average far below the deviations observed for other effective one-electron SO operators. For hydrogen halides HX (X = F, Cl, Br, I, At, and Uus) and mercury dihalides HgX2 (X = F, Cl, Br, I) trends in spinor energies and SO splittings as obtained with the 2cNESC method are analyzed and discussed on the basis of coupling schemes and the electronegativity of X.

A Survey of the Application of Multimedia in the Process of Teaching and Learning in KUiTTHO, Malaysia

ERIC Educational Resources Information Center

Kamaruddin, Nafisah Kamariah Md; Hamid, Mohd Zaidi Bin Abdul

2005-01-01

Scientific research shows that the process of remembering done in the human brain is faster when people receive many emphasizes in various forms for a short period. The concept of interactivity in multimedia helps the human brain to improve the process of learning. In addition, different approaches of multimedia make lessons very entertaining…

[Textual research on circulation of the Ming edition of Li Heng's Xiu zhen fang (Pocket Formulary)].

PubMed

Yang, Jinping; Liu, Peng; Lu, Mingjing; Lu, Xing; Li, Shaolin; Jin, Xiumei

2015-03-01

Xiu zhen fang (Pocket Formulary) is a recipe book of the Ming Dynasty, inspired and managed by Zhu Su, compiled by Li Heng of liangyisuo (good physician house) in Zhou wangfu (Zhou's royal palace). The book was compiled and published twice during the reigns of the Hongwu and Yongle Emperors of the Ming Dynasty. Because of its high practicability, there were some editions in circulation, and the book was published several times only in the Ming Dynasty. At present, the earliest extanteditionwas the little character version of Yongle, and the version in the 4(th) year of Zhengde Emperor of the Ming Dynasty was a reprinting edition based on the Yongle edition, sharingthe same edition system. Most of the editions appeared after the reign of Zhengtong Emperor of the Ming Dynasty, titled by "kui ben (head version)" and "da quan (complete edition)" were the editionspublished in the local bookshops, which had rather distinct differences from the Yongle edition system not only in the its format but also in its contents.

Software Technology for Adaptable, Reliable Systems (STARS): UUS40 - Risk-Reduction Reasoning-Based Development Paradigm Tailored to Navy C2 Systems

DTIC Science & Technology

1991-07-30

4 Management reviews, engineering and WBS -Spiral 0 -5 *Risk Management Planning -Spiral 0-5 ,41.- Unrelsi ugt .Proper initial planning -Spiral 0.1...Reusability issues for trusted systems are associated closely with maintenance issues. Reuse theory and practice for highly trusted systems will require

Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts

PubMed Central

Zheng, Luyu; Zhang, Weiyi; Jiang, Miao; Zhang, Huarong; Xiong, Fei; Yu, Yang; Chen, Meijuan; Zhou, Jing; Dai, Xiaoming; Jiang, Ming; Wang, Mingyan; Cheng, Ge; Duan, Jinao; Yu, Wei; Lin, Biaoyang; Fu, Haian; Zhang, Xu

2013-01-01

Many traditional Chinese medicine (TCM) formulae have been used in cancer therapy. The JIN formula is an ancient herbal formula recorded in the classic TCM book Jin Kui Yao Lue (Golden Chamber). The JIN formula significantly delayed the growth of subcutaneous human H460 xenografted tumors in vivo compared with the growth of mock controls. Gene array analysis of signal transduction in cancer showed that the JIN formula acted on multiple targets such as the mitogen-activated protein kinase, hedgehog, and Wnt signaling pathways. The coformula treatment of JIN and diamminedichloroplatinum (DDP) affected the stress/heat shock pathway. Proteomic analysis showed 36 and 84 differentially expressed proteins between the mock and DDP groups and between the mock and JIN groups, respectively. GoMiner analysis revealed that the differentially expressed proteins between the JIN and mock groups were enriched during cellular metabolic processes, and so forth. The ones between the DDP and mock groups were enriched during protein-DNA complex assembly, and so forth. Most downregulated proteins in the JIN group were heat shock proteins (HSPs) such as HSP90AA1 and HSPA1B, which could be used as markers to monitor responses to the JIN formula therapy. The mechanism of action of the JIN formula on HSP proteins warrants further investigation. PMID:24066008

Use of ethnic spices by adults in the United States: An exploratory study.

PubMed

Isbill, Jonathan; Kandiah, Jayanthi; Khubchandani, Jagdish

2018-01-01

Background: The use of complementary and alternative medicine (CAM) therapies has increased in the United States, but little is known about consumers' perceptions of use of such therapies. The purpose of this study was to assess knowledge, perceptions, and predictors of spice use for health promotion among adults in the Midwestern US. Methods: UUsing a cross-sectional study design, adults in the Midwestern US (n = 703) completed a valid and reliable survey which was pilot tested with a small convenience sample of adults (n = 38). The study variables included demographic profile, spice use behavior, perceptions about efficacy of spices, and willingness to use spices. Data were analyzed using SPSS to compute descriptive (e.g. percent and frequencies) and inferential statistics (i.e. logistic regression analyses). Results: Almost half of the participants were interested in learning about health benefits of spices (48%), indicated friends and family members as sources of information on spices (50%),and were willing to use spices as CAM therapies (51%). Most (>50%) of the participants were familiar with or had used eight out of the 10 listed spices. The majority of participants (54%)were currently using one or more spices on a daily basis and believed that ginger (64%), garlic(58%), and cinnamon (56%) could promote good health and wellness. In logistic regression analysis, age, gender (odds ratios [OR] = 1.44 and OR = 1.56), income (OR = 1.77), health status(OR = 2.01), and recommendations from healthcare providers (OR = 5.31 and OR = 3.96) were significant predictors of current spice use and willingness to use spices. Conclusion: Individuals in our study did not use many ethnic spices and were unaware of potential health benefits of spices. Greater awareness of ethnic spices for disease prevention and health promotion are needed in this population.

Use of ethnic spices by adults in the United States: An exploratory study

PubMed Central

Isbill, Jonathan; Kandiah, Jayanthi; Khubchandani, Jagdish

2018-01-01

Background: The use of complementary and alternative medicine (CAM) therapies has increased in the United States, but little is known about consumers’ perceptions of use of such therapies. The purpose of this study was to assess knowledge, perceptions, and predictors of spice use for health promotion among adults in the Midwestern US. Methods: UUsing a cross-sectional study design, adults in the Midwestern US (n = 703) completed a valid and reliable survey which was pilot tested with a small convenience sample of adults (n = 38). The study variables included demographic profile, spice use behavior, perceptions about efficacy of spices, and willingness to use spices. Data were analyzed using SPSS to compute descriptive (e.g. percent and frequencies) and inferential statistics (i.e. logistic regression analyses). Results: Almost half of the participants were interested in learning about health benefits of spices (48%), indicated friends and family members as sources of information on spices (50%),and were willing to use spices as CAM therapies (51%). Most (>50%) of the participants were familiar with or had used eight out of the 10 listed spices. The majority of participants (54%)were currently using one or more spices on a daily basis and believed that ginger (64%), garlic(58%), and cinnamon (56%) could promote good health and wellness. In logistic regression analysis, age, gender (odds ratios [OR] = 1.44 and OR = 1.56), income (OR = 1.77), health status(OR = 2.01), and recommendations from healthcare providers (OR = 5.31 and OR = 3.96) were significant predictors of current spice use and willingness to use spices. Conclusion: Individuals in our study did not use many ethnic spices and were unaware of potential health benefits of spices. Greater awareness of ethnic spices for disease prevention and health promotion are needed in this population. PMID:29423360

Chemical profiling approach to evaluate the influence of traditional and simplified decoction methods on the holistic quality of Da-Huang-Xiao-Shi decoction using high-performance liquid chromatography coupled with diode-array detection and time-of-flight mass spectrometry.

PubMed

Yan, Xuemei; Zhang, Qianying; Feng, Fang

2016-04-01

Da-Huang-Xiao-Shi decoction, consisting of Rheum officinale Baill, Mirabilitum, Phellodendron amurense Rupr. and Gardenia jasminoides Ellis, is a traditional Chinese medicine used for the treatment of jaundice. As described in "Jin Kui Yao Lue", a traditional multistep decoction of Da-Huang-Xiao-Shi decoction was required while simplified one-step decoction was used in recent repsorts. To investigate the chemical difference between the decoctions obtained by the traditional and simplified preparations, a sensitive and reliable approach of high-performance liquid chromatography coupled with diode-array detection and electrospray ionization time-of-flight mass spectrometry was established. As a result, a total of 105 compounds were detected and identified. Analysis of the chromatogram profiles of the two decoctions showed that many compounds in the decoction of simplified preparation had changed obviously compared with those in traditional preparation. The changes of constituents would be bound to cause the differences in the therapeutic effects of the two decoctions. The present study demonstrated that certain preparation methods significantly affect the holistic quality of traditional Chinese medicines and the use of a suitable preparation method is crucial for these medicines to produce special clinical curative effect. This research results elucidated the scientific basis of traditional preparation methods in Chinese medicines. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish

NASA Technical Reports Server (NTRS)

Riley, B. B.; Moorman, S. J.

2000-01-01

We have been studying the consequences of embryonic vestibular dysfunction caused by the monolith (mnl) mutation in zebrafish. mnl is a dominant mutation that specifically inhibits formation of utricular otoliths. However, briefly immobilizing mnl/mnl embryos in agarose with the otic vesicle orientated at certain angles selectively induces or prevents formation of utricular and/or saccular otoliths. With this noninvasive technique, we generated six phenotypic classes of mnl/mnl mutants, designated S-S, U-U, U-S, S-US, U-US, and US-US, depending on which otoliths are present on each side (U, utricular otolith; S, saccular otolith). All mnl/mnl larvae survived through day 10 of development. Thereafter, S-S larvae showed a rapid decline, probably because of starvation, and none survived to adulthood. Survival rates in all other classes of mnl/mnl larvae (those having at least one utricular otolith) were close to normal. The presence or absence of utricular otoliths also correlated with vestibular function during early larval development, as measured by three criteria: First, unlike wild-type larvae, S-S mutant larvae showed almost no detectable counter-rotation of the eyes when tilted tail up or tail down. Second, 95% of S-S mutant larvae never acquired the ability to maintain a balanced dorsal-up posture. Third, although most wild-type larvae responded to gentle prodding by swimming in a straight line, S-S larvae responded by swimming in rapid circles, showing sudden and frequent changes in direction ("zigzagging"), and/or rolling and spiraling. All other phenotypic classes of mnl/mnl larvae behaved normally in these assays. These data demonstrate that bilateral loss of utricular otoliths disrupts the ability to sense gravity, severely impairs balance and motor coordination, and is invariably lethal. The presence of a utricular otolith in at least one inner ear is necessary and sufficient for vestibular function and survival. In contrast, saccular otoliths are

Geography has more influence than language on maternal genetic structure of various northeastern Thai ethnicities.

PubMed

Kutanan, Wibhu; Ghirotto, Silvia; Bertorelle, Giorgio; Srithawong, Suparat; Srithongdaeng, Kanokpohn; Pontham, Nattapon; Kangwanpong, Daoroong

2014-09-01

Several literatures have shown the influence of geographic and linguistic factors in shaping genetic variation patterns, but their relative impact, if any, in the very heterogeneous northeastern region of Thailand has not yet been studied. This area, called Isan, is geographically structured in two wide basins, the Sakon Nakorn Basin and the Korat Basin, serving today as home to diverse ethnicities encompassing two different linguistic families, that is, the Austro-Asiatic; Suay (Kui), Mon, Chaobon (Nyahkur), So and Khmer, and the Tai-Kadai; Saek, Nyaw, Phu Tai, Kaleung and Lao Isan. In this study, we evaluated the relative role of geographic distance and barriers as well as linguistic differences as possible causes affecting the maternal genetic distances among northeastern Thai ethnicities. A 596-bp segment of the hypervariable region I mitochondrial DNA was utilized to elucidate the genetic structure and biological affinity from 433 individuals. Different statistical analyses agreed in suggesting that most ethnic groups in the Sakon Nakorn Basin are closely related. Mantel test revealed that genetic distances were highly associated to geographic (r = 0.445, P<0.01) but not to linguistic (r = 0.001, P>0.01) distances. Three evolutionary models were compared by Approximate Bayesian Computation. The posterior probability of the scenario, which assumed an initial population divergence possibly related to reduced gene flow among basins, was equal or higher than 0.87. All analyses exhibited concordant results supporting that geography was the most relevant factor in determining the maternal genetic structure of northeastern Thai populations.

Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.

PubMed

Xiong, Fei; Jiang, Miao; Chen, Meijuan; Wang, Xiaoxia; Zhang, Shiping; Zhou, Jing; Li, Ke; Sheng, Yan; Yin, Lian; Tang, Yuping; Ye, Lihong; Wu, Mianhua; Fu, Haian; Zhang, Xu

2017-01-01

MaiMenDong Decoction and WeiJing Decoction (Jin formula) is a traditional Chinese medication that consists of 8 medicinal plants, which recorded in the classical TCM literature Jin Kui Yao Lue and has been utilized in the treatment of lung diseases for hundreds of years in China. The present study aimed to determine the anti-tumor activity and the underlying mechanisms of Jin formula combined with cisplatin in the treatment of non-small cell lung cancer (NSCLC). Xenograft model of NCI-A549 was established in Balb/c nude mice. Five groups, including normal, MOCK, Jin, cisplatin (DDP), and Jin+DDP were included in the study. We found that Jin formula ameliorated the body weight loss caused by DDP 15 days after drug administration. Moreover, the combination of Jin with DDP enhanced the anti-tumor function of DDP. Microarray analysis showed that Jin suppressed gene expression of certain pathways which regulating cell cycle and apoptosis. Furthermore, DDP mainly decreased the gene expression level of angiogenesis associated factors, such as VEGFA, TGF-β and MMP-1. Moreover, co-treatment with Jin and DDP not only down-regulated Bcl-2 and E2F1, but also decreased the expression of MYC, MET, and MCAM. In addition, co-formula decreased the levels of p-AKT (thr308) and p-PTEN, increased Bax/Bcl-2 value, and resulted in apoptosis of tumor cells. Taken together , Jin+DDP significantly inhibited the growth of A549 cell transplanted solid tumor with slight side effect compared to the treatment by DDP only, and had a better effect than the Jin group. The mechanisms may be mainly associated with inactivation of PI3K/AKT pathway and apoptosis induction.

Does Eating Chicken Feet With Pickled Peppers Cause Avian Influenza? Observational Case Study on Chinese Social Media During the Avian Influenza A (H7N9) Outbreak.

PubMed

Chen, Bin; Shao, Jian; Liu, Kui; Cai, Gaofeng; Jiang, Zhenggang; Huang, Yuru; Gu, Hua; Jiang, Jianmin

2018-03-29

social media. Our findings suggested the importance of responding to common questions and misconceptions on social media platforms from the beginning of disease outbreaks. Authorities need to release clear and reliable information related to the popular topics early on. The microbloggers posting correct information should be empowered and their posts could be promoted to clarify false information. Equal importance should be attached to clarify misinformation in both the outbreak and nonoutbreak areas. ©Bin Chen, Jian Shao, Kui Liu, Gaofeng Cai, Zhenggang Jiang, Yuru Huang, Hua Gu, Jianmin Jiang. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 29.03.2018.

Spontaneous emission in dielectric nanoparticles

NASA Astrophysics Data System (ADS)

Pukhov, K. K.; Basiev, T. T.; Orlovskii, Yu. V.

2008-09-01

An analytical expression is obtained for the radiative-decay rate of an excited optical center in an ellipsoidal dielectric nanoparticle (with sizes much less than the wavelength) surrounded by a dielectric medium. It is found that the ratio of the decay rate A nano of an excited optical center in the nanoparticle to the decay rate A bulk of an excited optical center in the bulk sample is independent of the local-field correction and, therefore, of the adopted local-field model. Moreover, the expression implies that the ratio A nano/ A bulk for oblate and prolate ellipsoids depends strongly on the orientation of the dipole moment of the transition with respect to the ellipsoid axes. In the case of spherical nanoparticles, a formula relating the decay rate A nano and the dielectric parameters of the nanocomposite and the volumetric content c of these particles in the nanocomposite is derived. This formula reduces to a known expression for spherical nanoparticles in the limit c ≪ 1, while the ratio A nano/ A bulk approaches unity as c tends to unity. The analysis shows that the approach used in a number of papers {H. P. Christensen, D. R. Gabbe, and H. P. Jenssen, Phys. Rev. B 25, 1467 (1982); R. S. Meltzer, S. P. Feofilov, B. Tissue, and H. B. Yuan, Phys. Rev. B 60, R14012 (1999); R. I. Zakharchenya, A. A. Kaplyanskii, A. B. Kulinkin, et al., Fiz. Tverd. Tela 45, 2104 (2003) [Phys. Solid State 45, 2209 (2003)]; G. Manoj Kumar, D. Narayana Rao, and G. S. Agarwal, Phys. Rev. Lett. 91, 203903 (2003); Chang-Kui Duan, Michael F. Reid, and Zhongqing Wang, Phys. Lett. A 343, 474 (2005); K. Dolgaleva, R. W. Boyd, and P. W. Milonni, J. Opt. Soc. Am. B 24, 516 (2007)}, for which the formula for A nano is derived merely by substituting the bulk refractive index by the effective refractive index of the nanocomposite must be revised, because the resulting ratio A nano/ A bulk turns out to depend on the local-field model. The formulas for the emission and absorption cross

Environmental problems of resort towns of Caucasian Mineralnye Vody region during the anthropocene era

NASA Astrophysics Data System (ADS)

Efimenko, Natalia; Chalaya, Elena; Povolotckaia, Nina; Artamonova, Mariya; Senik, Irina; Slepykh, Viktor

2017-04-01

There has been studied the influence of ecological factors on rehabilitation properties of the atmospheric surface layer (ASL) in the mountain resorts of the Caucasian Mineralnye Vody Region (CMVR) according to the research methods [1] accepted in balneology. Taking into consideration the data of the long-term complex multiple-factor bioclimatic monitoring (PRIC FMBA, IFA RAS, SNP), it has been revealed: - the increase in frequency of inter-day variability of the integral index of weather pathogenicity (IIWP) in the range of 0,35KUI >2,0). These signs are noted on the background of the continuing period of climate warming. At the present time the rehabilitation potential of ASL in the resorts of Caucasian Mineralnye Vody region is estimated within 2,08-2,68 points (max =3,0 points). Mountainous areas are more sensitive to anthropogenic impacts, changes of radiation mode and circulation modes. It was revealed that

Specific weather biotrop factors in the mountain resorts of North Caucasus

NASA Astrophysics Data System (ADS)

Efimenko, Natalia; Chalaya, Elena; Povolotckaia, Nina; Senik, Irina; Slepykh, Victor

2015-04-01

Key aspects of weather therapeutic action in the mountain resorts of the Northern Caucasus (RNC) are formed under the combined influence of global, regional and local atmospheric processes, picturesque landscape, vegetation which create specificity and attraction of the weather regime for the interests of resort rehabilitation, recreation and tourism practically during the whole year. They include high purity of surface atmosphere (background level of aerosols for the countryside, the transparency of the atmosphere 0.780 -0.890); natural hypo barium and hypoxia (5-10%); increased natural aeroionization (N+=400-1000 ion/cm3; N- = 600-1200 ion/cm3; KUI = 0.8 -1.0); the softness of temperature rate (± 600 W/m ); regime of solar radiation favourable for heliotherapy. Pathogenic effects in the mountains can occur both in front atmospheric processes and in conditions of relatively favorable weather. For example, in a stable anti-cyclonic air mass with the sunny weather, foehn effects can happen that are accompanied by excessively low air humidity (lower than 20-30%), the air temperature rises in the afternoon (in winter until 15- 20°C, in summer - up to 25-35°C). The situation can be worsened by ozone intrusion (O3) with the increase of its concentration by 20 ppb or more, temperature stratification change, formation of pollution accumulation conditions in the gorges and valleys where the resort towns are located. We can observe: the increase in the concentration of aerosol pollution from 1.78 to 4 and even up to 8-10 particles/cm (particle diameter is 500-1000 nm); the rise in mass concentration of submicron aerosol up to 75 mkg/m3 and the gas pollution (CO, COx, O3) of the surface atmosphere. Against this backdrop the effects of rapid changes in the chemical composition of natural ions due to the formation of positive nitrogen ions (often with a prevalence of positive over negative air ions) can be sometimes developed. In such situations people suffering from

Air quality in the mountain climate-balneological resort Kislovodsk

NASA Astrophysics Data System (ADS)

Chalaya, Elena; Efimenko, Natalia; Povolotckaia, Nina; Senik, Irina; Slepykh, Victor

2016-04-01

There has been studied the quality of the surface atmosphere in the mountain climate-balneological resort Kislovodsk (MCBRK) to treat by means of climate and landscape (TCL) of the patients suffering from bronchial asthma (PBA) [1]. 60 children (31 boys and 29 girls at the age of 9-11 years) were examined in the course of 34 days of the resort treatment in MCBRK, PBA (ICD-10 G45,0) in a remission stage. There have been used the data of the long-term bioclimatic monitoring (BCM) that is carried out by PRIC FMBA, aerosol monitoring of IFA RAS, landscape monitoring of SNP in Kislovodsk Resort Park (KRP) as well as the data of medical monitoring, daily testing of meteopathic reactions (MPR), indicators dynamics of bronchial patency, cardiac rhythm, neurovascular reactivity, psychoemotional status of patients. TCL was carried out in the form of walks under the canopy of Betula pendula Roth., Salix f. pendula, acer platanoides globosum, Aesculus hippocastanum L., Phellodendron amurense, Tilia caucasica in KRP daily lasting from 1 till 2 hours. The results of a complex research showed that at TCL in KRP the favourable heat balance had 92% warm relations (TB<600BT/m2 - comfort and weak over comfort); the increased natural aero ionization (∑(N+)+(N-)=1350-1850 ion/cm3 at KUI<0,88); bacteriostatics natural trees 13-58%; the level of the weighed aerosol particles (the size of 500-20000 nanometers) from 1,2 to 3,6 particles/cm3 - (from pure to poorly polluted atmosphere); only 86% of the patients had cases with the increased and high transparency of the atmosphere (0,756-0,849). Under the influence of the course TCL 53(88%) patients had improved indicators of bronchial patency, 58(97%) had signs of increasing qualities of regulatory processes in the organism (vegetative regulation for 14%; neurohumoral regulation for 12%; psychoemotional regulation for 16%; the ability of the organism to adaptation for 17%); 38(63%) patients had vegetative index of Kerde that reached normal