Investigation of Seismic Events associated with the Sinkhole at Napoleonville Salt Dome, Louisiana

NASA Astrophysics Data System (ADS)

Nayak, A.; Dreger, D. S.

2015-12-01

This study describes the ongoing efforts in analysis of the intense sequence of complex seismic events associated with the formation of a large sinkhole at Napoleonville Salt Dome, Assumption Parish, Louisiana in August 2012. Point source centroid seismic moment tensor (MT) inversion of these events using data from a temporary network of broadband stations established by the United States Geological Survey had previously revealed large volume-increase components. We investigate the effect of 3D velocity structure of the salt dome on wave propagation in the frequency range of interest (0.1-0.3 Hz) by forward modeling synthetic waveforms using MT solutions that were computed using Green's functions assuming two separate 1D velocity models for stations over the salt dome and stations on the sedimentary strata surrounding the salt dome separately. We also use a matched filter technique to detect smaller events that went undetected by the automated grid-search based scanning and MT inversion algorithm using the waveforms of the larger events as templates. We also analyze the change in spectral content of the events, many of which exhibit a spectral peak at 0.4 Hz with a duration of > 60 seconds. The decrease in spectral amplitudes with distance also gives an estimate of high anelastic attenuation that damps reverberations within the shallow low velocity layers. Finally, we use noise cross-correlation analysis to explore changes in the green's functions during the development of the sinkhole and verify the sediment velocity model by comparing observed and synthetic surface wave dispersion.

Sinkhole formation and hydrogeological situation at the salt mining area of Solotvyno, Ukraine

NASA Astrophysics Data System (ADS)

Stoeckl, L.; Banks, V.

2017-12-01

In Solotvyno, Ukraine, several salt mines were unexpectedly flooded in the recent past. As a result, dozens of sinkholes formed and are still forming with diameters up to 250 m. A one month advisory mission by the European Commission was launched in fall 2016 to conduct a risk assessment. The former mining area is situated in close vicinity to the river Theiss, which is the largest contributory of the largest river in Europe: the Danube. As river contamination by the release of large quantities of saltwater would lead to an international disaster, hydrogeological measurements were taken on-site to study the system. Saturated (hyper-saline) water as well as fresh surface and groundwater were encountered in different locations of the former mining area. Water samples were analyzed for chemistry and stable isotopes at BGR revealing insight into groundwater flow dynamics. Satellite imaging and interferometric synthetic aperture radar (SAR) were applied to study ground movements and evaluate the risk of further collapses. A resulting conceptual model explains the processes of sinkhole formation as well as the natural restoration of the salt dome prior to mining operations. This study shows the advantage of an interdisciplinary approach to conduct a risk assessment in the case of large mine collapses.

Identification, prediction, and mitigation of sinkhole hazards in evaporite karst areas

USGS Publications Warehouse

Gutierrez, F.; Cooper, A.H.; Johnson, K.S.

2008-01-01

Sinkholes usually have a higher probability of occurrence and a greater genetic diversity in evaporite terrains than in carbonate karst areas. This is because evaporites have a higher solubility and, commonly, a lower mechanical strength. Subsidence damage resulting from evaporite dissolution generates substantial losses throughout the world, but the causes are only well understood in a few areas. To deal with these hazards, a phased approach is needed for sinkhole identification, investigation, prediction, and mitigation. Identification techniques include field surveys and geomorphological mapping combined with accounts from local people and historical sources. Detailed sinkhole maps can be constructed from sequential historical maps, recent topographical maps, and digital elevation models (DEMs) complemented with building-damage surveying, remote sensing, and high-resolution geodetic surveys. On a more detailed level, information from exposed paleosubsidence features (paleokarst), speleological explorations, geophysical investigations, trenching, dating techniques, and boreholes may help in investigating dissolution and subsidence features. Information on the hydrogeological pathways including caves, springs, and swallow holes are particularly important especially when corroborated by tracer tests. These diverse data sources make a valuable database-the karst inventory. From this dataset, sinkhole susceptibility zonations (relative probability) may be produced based on the spatial distribution of the features and good knowledge of the local geology. Sinkhole distribution can be investigated by spatial distribution analysis techniques including studies of preferential elongation, alignment, and nearest neighbor analysis. More objective susceptibility models may be obtained by analyzing the statistical relationships between the known sinkholes and the conditioning factors. Chronological information on sinkhole formation is required to estimate the probability of

High-resolution InSAR constraints on flood-related subsidence and evaporite dissolution along the Dead Sea shores: Interplay between hydrology and rheology

NASA Astrophysics Data System (ADS)

Shviro, Maayan; Haviv, Itai; Baer, Gidon

2017-09-01

Sinkhole generation and land subsidence are commonly attributed to dissolution of subsurface layers by under-saturated groundwater and formation of cavities. Along the Dead Sea (DS) shorelines, this process also involves seasonal flash floods that are drained into the subsurface by existing and newly formed sinkholes. We quantify the contribution of flash-floods to salt dissolution and land subsidence using high-resolution interferometric synthetic aperture radar (InSAR). Subsidence rates during a 3-year period (2012-2015) were calculated from 57 COSMO SkyMed X-band interferograms bracketing major flood events and intra-flood periods in 21 sinkhole sites. The sites are located within channels and alluvial fans along the western shores of the Dead Sea, Israel. The observed subsidence reaches maximum rates of 2.5 mm/day, accumulating in specific sites to 500 mm/year. In most of the sinkhole sites a gradual increase in the annual subsidence rate is observed during the 3-year study period. Three different modes of response to floods were observed: (1) sites where floodwater is not directly channeled into sinkholes do not respond to floods; (2) sites adjacent to active channels with sinkholes are unaffected by specific floods but their subsidence rates increase gradually from early winter to mid-summer, and decay gradually until the following winter; and (3) sites in active channels with sinkholes are characterized by an abrupt increase in subsidence rates immediately after each flood (by a factor of up to 20) and by a subsequent quasi-exponential subsidence decay over periods of several months. In these latter sites, subsidence rates after each flood are temporally correlated with alternating groundwater levels in adjacent boreholes. The rapid rise in groundwater head following floods increases the hydraulic gradient of the under-saturated groundwater and hence also the groundwater discharge and the dissolution rate of the subsurface salt layer. A subsequent quasi

Spatio-temporal development of sinkholes on the eastern shore of the Dead Sea

NASA Astrophysics Data System (ADS)

Holohan, Eoghan; Saberi, Leila; Al-Halbouni, Djamil; Sawarieh, Ali; Closson, Damien; Alrshdan, Hussam; Walter, Thomas; Dahm, Torsten

2017-04-01

The ongoing, largely anthropogenically-forced decline of the Dead Sea is associated with the most prolific development of sinkholes worldwide. The fall in hydrological base level since the 1960s is thought to enable relatively fresh ground waters to dissolve underground salt deposits that were previously in equilibrium with hypersaline Dead Sea brine. Sinkhole development in response to this dissolution began in the 1980s and is still ongoing; it represents a significant geohazard in the Dead Sea region. We present new research undertaken within the Dead Sea Research Venue (DESERVE) on the spatio-temporal evolution of the main sinkhole-affected site on the Eastern shore of the Dead Sea, at Ghor Al-Haditha in Jordan. Our data set includes optical satellite imagery, aerial survey photographs and drone-based photogrammetric surveys with high spatial (< 1 m2 - 0.05 m per pixel) and temporal (decadal from 1970-2010, annual from 2004-2016) resolution. These enable new quantitative insights into this, the largest of all the Dead Sea sinkhole sites. Our analysis shows that there are now over 800 sinkholes at Ghor al-Haditha. Sinkholes initiated as spatially distinct clusters in the late 1980's to early 1990s. While some clusters have since become inactive, most have expanded and merged with time. New clusters have also developed, mainly in the more recently exposed north of the area. With the retreat of the Dead Sea, the roughly coastline-parallel zone of sinkhole formation has expanded unevenly but systematically seawards. Such a seaward migration of sinkhole formation is predicted from hydrogeological theory, but as yet not consistently observed elsewhere at the Dead Sea. The rate of sinkhole formation at Ghor Haditha accelerated markedly during the late 2000s to a peak of about 100 per year in 2009. Similar accelerations are observed on the western shore, but differ in timing. The rate of sinkhole formation on the Eastern shore has since declined to about 50 per year

Dissolution of Permian salt and Mesozoic depositional trends, Powder River basin, Wyoming

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rasmussen, D.L.; Bean, D.W.

1983-08-01

Salt deposits in the Powder River basin of Wyoming occur in the Late Permian Ervay Member of the Goose Egg Formation which was deposited in a redbed-evaporite trend extending from the Williston basin of North Dakota to the Alliance basin of Nebraska and Wyoming. However, only remnants of the once extensive Ervay salt remain in the Powder River basin, with major salt dissolution events occurring during Late Jurassic and Early Cretaceous. Subsidence and deposition at the surface were contemporaneous with subsurface salt dissolution except in areas where uplift and erosion were occurring. Earliest dissolution of the Ervay salt occurred inmore » the Jurassic, during regional uplift and erosion of the overlying Triassic Chugwater Formation in the present Hartville uplift and southeastern Powder River basin areas. Thickness variations of the Canyon Springs and Stockade Beaver members of the early Late Jurassic Sundance Formation, which unconformably overlie the deeply eroded Chugwater Formation, may be related in part to dissolution of the Ervay salt. Extensive salt dissolution, synsubsidence, and syndeposition occurred throughout most of the Powder River basin during the latest Jurassic and Early Cretaceous. Many producing fields from the Mowry, Muddy, and Dakota formations exhibit either rapid stratigraphic changes syndepositional to salt collapse or fracture-enhanced reservoir quality due to postdepositional salt collapse. Major Muddy accumulations occurring in areas of local Ervay salt collapse include Kitty, Hilight, Fiddler Creek, and Clareton which have produced jointly over 172 million bbl of oil. The relationship of Ervay salt dissolution to Lower Cretaceous deposition can be exploited as an effective exploration tool.« less

Mechanism of Sinkhole Formation in the Ghor Al-Haditha Based on Geophysical Data

NASA Astrophysics Data System (ADS)

Akawwi, E.; Al-Zoubi, A.; Abueadas, A.; Eppelbaum, L.; Ezersky, M.; Levi, E.; Legchenko, A.; Boucher, M.

2012-04-01

Dead Sea sinkholes have been forming along the Dead Sea coastal areas in both Israel and Jordan during three last decades. Sinkholes developing in the Ghor Al-Haditha Area affect in roads, agriculture lands, and building foundations by the sudden collapse of the ground surface and cracks with different sizes and depths. If mechanism of sinkhole formation along western Dead Sea shore has been studied goodly enough eastern side requires additional interpretation of data available. The situation in Jordan is complicated by complicated geology and absence of data on salt layers from the verification boreholes. The exposed walls of sinkholes also demonstrated that much of this geological sequence near the surface is composed of sand, silty sand and gravel, in addition to some evaporates minerals (dominantly salt and gypsum). It is understood today that sinkholes are formed within Holocene salt layers located after seismic refraction data at shallow depths of 40-50 meters. Different models suggested by different investigating groups have been suggested. There are models based on surface measurements (InSAR Radar), Microgravity modeling, visual inspection of sinkhole sites etc. The flushing model based on the assumption that turbulent underground water flows associated with a massive mass transport of insoluble fractions (clay and silt) have produced subsurface hollows. These expand upwards and finally appear on the surface as sinkholes. We develop model based on different geophysical studies using seismic reflection and refraction methods, Magnitometry and Microgravity, Electric resistivity Tomography (ERT) and Ground Penetrating Radar (GPR), Magnetic Resonance Sounding (MRS) method, Transient Electromagnetic (TEM) method etc. These data allows suggesting the geophysical model of sinkhole formation mechanism. Our model considers the salt edge as a major factor of sinkhole formation with some features associated with tectonic setting and hydrogeology. The salt model is

CORS 911 : continuously operating reference stations for the Bayou Corne sinkhole.

DOT National Transportation Integrated Search

2013-06-01

The sinkhole located near the Napoleonville Salt Dome in Assumption Parish, Louisiana : threatens the stability of LA 70 a state maintained route. In order to mitigate the : possible damaging eff ects of the sinkhole to the route and address publ...

Basic processes and factors determining the evolution of collapse sinkholes: a sensitivity study

NASA Astrophysics Data System (ADS)

Romanov, Douchko; Kaufmann, Georg

2017-04-01

Collapse sinkholes appear as closed depressions at the surface. The origin of these karst features is related to the continuous dissolution of the soluble rock caused by a focussed sub-surface flow. Water flowing along a preferential pathway through fissures and fractures within the phreatic part of a karst aquifer is able to dissolve the rock (limestone, gypsum, anhydrite). With time, the dissolved void volume increases and part of the ceiling above the stream can become unstable, collapses, and accumulates as debris in the flow path. The debris partially blocks the flow and thus activates new pathways. Because of the low compaction of the debris (high hydraulic conductivity), the flow and the dissolution rates within this crushed zone remain high. This allows a relatively fast dissolutional and erosional removal of the crushed material and the development of new empty voids. The void volume expands upwards towards the surface until a collapse sinkhole is formed. The collapse sinkholes exhibit a large variety of shapes (cylindrical, cone-, bowl-shaped), depths (from few to few hundred meters) and diameters (meters up to hundreds of meters). Two major processes are responsible for this diversity: a) the karst evolution of the aquifer - responsible for the dissolutional and erosional removal of material; b) the mechanical evolution of the host rock and the existence of structural features, faults for example, which determine the stability and the magnitude of the subsequent collapses. In this work we demonstrate the influence of the host rock type, the hydrological and geological boundary conditions, the chemical composition of the flowing water, and the geometry and the scale of the crushed zone, on the location and the evolution of the growing sinkhole. We demonstrate the ability of the karst evolution models to explain, at least qualitatively, the growth and the morphology of the collapse sinkholes and to roughly predict their shape and location. Implementing

A geomechanical model of a sinkhole formation

NASA Astrophysics Data System (ADS)

Danchiv, Alexandru; Zamfirescu, Florian; Mocuta, Marius; Popa, Iulian; Zlibut, Alexandru; Huggenberger, Peter; Zechner, Eric; Dresmann, Horst; Scheidler, Stefan; Wiesmeier, Stefan

2016-04-01

On December 2010 a sinkhole was suddenly formed close to the eastern flank of Ocna-Mures salt dome. Soon after the collapse the sinkhole was filled with brine forming a salt lake called Plus Lake. The total volume of sinkhole of about 100000 m3 remained constant since February 2011. The Ocna Mures salt dome is situated on the western border of the Transylvanian basin (Romania) and has been exploited for a long time. The ceilings of some shallow mine chambers are now collapsed and filled with brine. Along the eastern flank of the salt dome there is a disturbed zone due to diapirism. Its presence is suggested by the strong fragmentation of rock in the boreholes drilled along the salt-sterile contact, as it resulted from the low values of RQD index. The sinkhole is probably due to a pressure increase along the diapir flank. The causes of this sudden increase of pressure are not well known. Most probably it is due to the damage of the tubing of a flank borehole as mentioned in a technical report of the exploiting company. The injected fresh water expelled through the breaches of the damaged borehole and, due to the high pressure flushed up the crushed material of the disturbed zone. In order to better understand the setting up of the Plus Lake joint research efforts were performed by teams from Bucharest and Basel Universities since 2013. For the geomechanical approach a numerical model was performed using the Flac 7.0 code. In a first stage the creep behavior of salt was analyzed considering a Norton creep law. It resulted that after 100 years the salt reached equilibrium, the creep could be neglected and in a first approximation mechanical equilibrium could be analyzed considering only an elasto-plastic behavior of both the salt and the sterile. For both the salt and the surrounding sedimentary rocks the Mohr-Coulomb criterion was considered. The properties of sterile rocks were estimated following the GSI system. Due to poor rock quality the strength parameters have

Subsidence and collapse sinkholes in soluble rock: a numerical perspective

NASA Astrophysics Data System (ADS)

Kaufmann, Georg; Romanov, Douchko; Hiller, Thomas

2016-04-01

Soluble rocks such as limestone, gypsum, anhydrite, and salt are prone to subsidence and the sudden creation of collapse sinkholes. The reason for this behaviour stems from the solubility of the rock: Water percolating through fissures and bedding partings can remove material from the rock walls and thus increase the permeability of the host rock by orders of magnitudes. This process occurs on time scales of 1,000-100,000 years, resulting in enlarged fractures, voids and cavities, which then carry flow efficiently through the rock. The enlargement of sub-surface voids to the meter-size within such short times creates mechanical conditions prone to collapse. The collapse initiates at depth, but then propagates to the surface. By means of numerical modelling, we discuss the long-term evolution of secondary porosity in gypsum rocks, resulting in zones of sub-surface voids, which then become mechanically unstable and collapse. We study two real-world case scenarios, in which we can relate field observations to our numerical model: (i) A dam-site scenario, where flow around the dam caused widespread dissolution of gypsum and subsequent subsidence of the dam and a nearby highway. (ii) A natural collapse sinkhole forming as a result of freshwater inflow into a shallow anhydrite formation with rapid evolution of voids in the sub-surface.

Distinct Element modeling of geophysical signatures during sinkhole collapse

NASA Astrophysics Data System (ADS)

Al-Halbouni, Djamil; Holohan, Eoghan P.; Taheri, Abbas; Dahm, Torsten

2017-04-01

A sinkhole forms due to the collapse of rocks or soil near the Earth's surface into an underground cavity. Such cavities represent large secondary pore spaces derived by dissolution and subrosion in the underground. By changing the stress field in the surrounding material, the growth of cavities can lead to a positive feedback, in which expansion and mechanical instability in the surrounding material increases or generates new secondary pore space (e.g. by fracturing), which in turn increases the cavity size, etc. A sinkhole forms due to the eventual subsidence or collapse of the overburden that becomes destabilized and fails all the way to the Earth's surface. Both natural processes like (sub)surface water movement and earthquakes, and human activities, such as mining, construction and groundwater extraction, intensify such feedbacks. The development of models for the mechanical interaction of a growing cavity and fracturing of its surrounding material, thus capturing related precursory geophysical signatures, has been limited, however. Here we report on the advances of a general, simplified approach to simulating cavity growth and sinkhole formation by using 2D Distinct Element Modeling (DEM) PFC5.0 software and thereby constraining pre-, syn- and post-collapse geophysical and geodetic signatures. This physically realistic approach allows for spontaneous cavity development and dislocation of rock mass to be simulated by bonded particle formulation of DEM. First, we present calibration and validation of our model. Surface subsidence above an instantaneously excavated circular cavity is tracked and compared with an incrementally increasing dissolution zone both for purely elastic and non-elastic material.This validation is important for the optimal choice of model dimensions and particles size with respect to simulation time. Second, a cavity growth approach is presented and compared to a well-documented case study, the deliberately intensified sinkhole collapse at

Detection of sinkhole precursors along the Dead Sea, Israel by SAR interferometry

NASA Astrophysics Data System (ADS)

Nof, Ran; Baer, Gidon; Ziv, Alon; Eyal, Yehuda; Raz, Eli; Atzori, Simone; Salvi, Stefano

2013-04-01

The water level of the Dead Sea (Israel and Jordan) has been dropping at an increasing rate since the 1960s, exceeding a meter per year during the last decade. This water-level drop has triggered the formation of sinkholes and widespread land subsidence along the Dead Sea shorelines, resulting in severe economic loss and infrastructural damage. In this study, sinkhole-related precursory subsidence and the effects of human activities on sinkhole development are examined through Interferometric Synthetic Aperture Radar (InSAR) measurements and field surveys conducted in Israel during the year 2012. Interferograms were generated using the COSMO-SkyMed satellite images and a high-resolution (0.5 m/pixel) elevation model that was obtained from airborne Light Detection and Ranging (LiDAR). Thanks to this unique integration of high-resolution datasets, mm-scale subsidence may be resolved in both undisturbed and human-disturbed environments. A few months long precursory subsidence occurred in all three sinkhole sites reported in this study. The centers of the subsiding areas and successive sinkholes in a specific site show lateral migration, possibly due to progressive dissolution and widening of the underlying cavities. Certain human activities, such as filling of newly formed sinkholes by gravel, or mud injections into nearby drill holes, seem to enhance land subsidence, widen existing sinkholes or even generate new sinkholes.

Geophysical analysis of the recent sinkhole trend at Ghor-Haditha (Dead Sea, Jordan)

NASA Astrophysics Data System (ADS)

Camerlynck, Christian; Bodet, Ludovic; Galibert, Pierre-Yves; Boucher, Marie; Al-Zoubi, Abdallah

2013-04-01

For essentially the last 30 year the water level of the Dead Sea has highly dropped. One of the major associated facts is sinkhole occurrences along the shoreline both in Jordan and Israel. As the principal invoked mechanism, many studies have concluded that sinkhole formation results from the dissolution of a previously immersed salt layer, progressively in contact with fresh to brackish water. In Jordan, the triggering of this phenomenon could also be the result of particular tectonic settings, associated with the Jordan-Dead Sea transform fault system. At Ghor Haditha (south-est Jordan), the consequences have been dramatic for farmers with the shrinking of temporary available lands and industry with the closing of at least one factory. The shallow material in this area is heterogeneous and composed of intercalated sand and clay layers of alluvial-colluvial origin, over a salty substratum, whose precise depth and thickness are yet partially hypothesized. Between 2005 and 2008, a multi-method high-resolution geophysical survey was performed, approximately over a 1 km2 area at Ghor Haditha, associating mainly electromagnetic soundings, magnetic resonance soundings (MRS), and seismic profiling, ground-penetrating radar and electrical resistivity tomography. At the same time, this specific area was the location of a dramatic evolution of sinkhole occurences, regularly followed by geodetic measurements. Over the 3 years period, about 120 TEM (Transient ElectroMagnetic) soundings allow to map precisely the depth of the conductive layers below the resistive overburden. Two conductive layer are then revealed, the latter showing the lowest resistivity below 1 Ohm.m corresponding to the saline substratum. Several MRS (3 in 2005, repeated in 2007 and 12 additional soundings) show an east-west hydraulic gradient towards the Dead. However, the main sinkhole trend coincides with both: - a clear low transmissivity axis determined from MRS measurements; - the western side of a

Groundwater flow velocity measurements in a sinkhole at the Weeks Island Strategic Petroleum Reserve Facility, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ballard, S.; Gibson, J.

1995-02-01

In 1992, a sinkhole was discovered above a Strategic Petroleum Reserve storage facility at Weeks Island, Louisiana. The oil is stored in an old salt mine located within a salt dome. In order to assess the hydrologic significance of the sink hole, an In Situ Permeable Flow Sensor was deployed within a sand-filled conduit in the salt dome directly beneath the sinkhole. The flow sensor is a recently developed instrument which uses a thermal perturbation technique to measure the magnitude and direction of the full 3-dimensional groundwater flow velocity vector in saturated, permeable materials. The flow sensor measured substantial groundwatermore » flow directed vertically downward into the salt dome. The data obtained with the flow sensor provided critical evidence which was instrumental in assessing the significance of the sinkhole in terms of the integrity of the oil storage facility.« less

Multi-sensor technologies for analyzing sinkholes in Hamedan, west Iran

NASA Astrophysics Data System (ADS)

Vajedian, Sanaz; Motagh, Mahdi; Hojati, Ahmad; Wetzel, Hans-Ulrich

2017-04-01

Dissolution of the carbonate beds such as limestone, dolomite or gypsum by acidic groundwater flowing through fractures and joints in the bedrock alters land surface and enhances the development of sinkholes. Sinkhole formation causes the surface to subside or even collapse suddenly without any prior warning, leading to extensive damage and sometimes loss of life and property, in particular in urban areas. Delineating sinkholes is critical for understanding hydrological processes and mitigating geological hazards in karst areas. The recent availability of high-resolution digital elevation models (DEM) from TanDEM-X (TDX) mission enables us to delineate and analyze geomorphologic features and landscape structures at an unprecedented level of details, in comparison to previous missions such as c-band and x-band Shuttle Radar Topography Mission (SRTM). In this study, we develop an adaptive sinkhole-delineating method based on photogrammetry techniques to detect karst sinkholes in Hamedan , west Iran, using TDX-derived DEMs. We apply automatic feature extraction using watershed algorithm in order to detect depression areas. We show that using high-resolution TDX data from different geometries and time periods we could effectively distinguish sinkholes from other depression features of the basin. We also use interferometric synthetic aperture radar (InSAR) technique with SAR data acquired from a variety of sensors including Envisat, ALOS, TerraSAR-X and Sentinel-1 to quantify long-term subsidence in areas prone to sinkhole formation. Our results indicate that the formation of a lot of sinkholes is influenced by land subsidence, affecting the region over 100 km with the maximum rate of 4-5 cm/yr during 2003 to 2016.

Students' Understanding of Salt Dissolution: Visualizing Animation in the Chemistry Classroom

NASA Astrophysics Data System (ADS)

Malkoc, Ummuhan

The present study explored the effect of animation implementation in learning a chemistry topic. 135 high school students taking chemistry class were selected for this study (quasi-experimental groups = 67 and control groups = 68). Independent samples t-tests were run to compare animation and control groups between and within the schools. The over-arching finding of this research indicated that when science teachers used animations while teaching salt dissolution phenomena, students will benefit the application of animations. In addition, the findings informed the TPACK framework on the idea that visual tools are important in students' understanding of salt dissolution concepts.

Dissolution of salt on the east flank of the Permian Basin in the southwestern U.S.A.

USGS Publications Warehouse

Johnson, K.S.

1981-01-01

Hydrogeologic studies prove that natural dissolution of bedded salt occurs at shallow depths in many parts of the Permian Basin of the southwestern U.S.A. This is especially well-documented on the east side of the basin in study areas on the Cimarron River and Elm Fork in western Oklahoma, and on the Red River in the southeastern part of the Texas Panhandle. Four requirements for salt dissolution are: (1) a deposit of salt; (2) a supply of water unsaturated with respect to NaCl; (3) an outlet for removal of brine; and (4) energy to cause water to flow through the system. The supply of fresh groundwater in the region is recharged through permeable rocks, alluvium, terrace deposits, karstic features and fractures. Groundwater dissolves salt at depths of 10-250 m, and the resulting brine moves laterally and upward under hydrostatic pressure through caverns, fractures in disrupted rock, and clastic or carbonate aquifers until it reaches the land surface, where it forms salt plains and salt springs. In many areas, salt dissolution produces a self-perpetuating cycle: dissolution causes cavern development, followed by collapse and subsidence of overlying rock; then the resulting disrupted rock has a greater vertical permeability that allows increased water percolation and additional salt dissolution. ?? 1981.

Mapping and modelling of collapse sinkholes in soluble rock: the Münsterdorf site, northern Germany

NASA Astrophysics Data System (ADS)

Kaufmann, Georg; Romanov, Douchko

2017-04-01

Münsterdorf is a small village in the north of Hamburg, located along the northern rim of a salt diapir. The Permian rocks are uplifted and overlying rocks such as the cretaceous limestone, normally in several kilometres depth, have been pushed up close to the surface. In Münsterdorf, the cretaceous limestone can be found in around 20 m depth, and about 2 km further south, cretaceous limestones are quarried in a large open-pit mine. Since 2004, collapse sinkholes form on a sporting ground in Münsterdorf, with a frequency of about 1 per year, about 2-3 m in diameter and 3-5 m deep. The collapse sinkholes do not reach the underlying limestone, but seem to be related to accelerated dissolution in that formation. Above the cretacious limestone, quaternary gravels and glacial marls provide a non-soluble, but permeable and heterogeneous cover of about 20 m thickness. We have mapped the sporting ground and its vicinity with gravity (GRAV), electrical resistivity imaging (ERI), self-potential measurements (SP), and ground-penetrating radar (GPR). While GRAV and SP is fairly unspectacular, the ERI profiles indicate a significant change in the surface layer, from thin and irregular in the northern part to thicker and more homogeneous in the southern part of the sporting ground. GPR profiles confirm this result. With numerically modelling the evolution of flow and porosity in the cretaceous limestone, we discuss the potential cause of the sinkhole formation and its sudden onset.

Sinkhole Geohazard In Deformed Sulphates at Marina di Lesina (Gargano Promontory, Italy): a Combination of Anthropogenic, Lithologic, and Structural Causes

NASA Astrophysics Data System (ADS)

Gabbianelli, G.; Antonellini, M.; Mancini, F.; Stecchi, F.; Castellarin, A.

2009-04-01

Sinkhole development and collapse of underground caves within a gypsum substrate is focused in proximity to the beach resort of Marina di Lesina on the Adriatic coast of Southern Italy. This situation constitutes a serious geohazard for the local community and a threat to the development of the tourist activity. Fast sinkhole development has been reported in the last two decades both in terms of newly formed cavities and of widening of already existing ones. Morphologically, the apparent sinkholes are small (from a few meters to a few tens of meters) and restricted to the area of the harbour canal. The substratum of the area consists of evaporite and carbonate platfom sediments of the Apulian margin, Triassic to Cretaceous in age, above which there is a thin layer (2 to 4 m) of Quaternary fine to medium sand deposits. Sheared marls, sub-volcanic igneous rocks, and bituminous limestone connected to a fault scarp, as well as small salt diapirs have been observed in proximity to the city. Below the urban area of Marina di Lesina, the platform sediments consist of fractured, sheared, and karstified sulfates (Burano Formation). Given solubility larger than that of carbonate rock, sulfates is a focus for the dissolution process. From a structural point of view, the Marina di Lesina area is probably in a push-up step between two secondary segments of East-West trending left lateral strike-slip faults with the same trend of the Mattinata fault system. The presence of a push-up structure is confirmed by the existing geological maps, the morphological, and the altimetry data available for the area that point out the presence of arcuate relief structures next to the Pietre Nere (Black Rocks) Head. These high relief areas are probable NW-SE oriented high angle reverse faults in the compressional quadrant of the southernmost strike-slip fault segment. The area within a push-up step is undergoing an intense compressive stress that results in strong pressure solution phenomena

High-resolution seismic-reflection imaging 25 years of change in I-70 sinkhole, Russell County, Kansas

USGS Publications Warehouse

Miller, R.D.; Steeples, D.W.; Lambrecht, J.L.; Croxton, N.

2006-01-01

Time-lapse seismic reflection imaging improved our understanding of the consistent, gradual surface subsidence ongoing at two sinkholes in the Gorham Oilfield discovered beneath a stretch of Interstate Highway 70 through Russell and Ellis Counties in Kansas in 1966. With subsidence occurring at a rate of around 10 cm per year since discovery, monitoring has been beneficial to ensure public safety and optimize maintenance. A miniSOSIE reflection survey conducted in 1980 delineated the affected subsurface and successfully predicted development of a third sinkhole at this site. In 2004 and 2005 a high-resolution vibroseis survey was completed to ascertain current conditions of the subsurface, rate and pattern of growth since 1980, and potential for continued growth. With time and improved understanding of the salt dissolution affected subsurface in this area it appears that these features represent little risk to the public from catastrophic failure. However, from an operational perspective the Kansas Department of Transportation should expect continued subsidence, with future increases in surface area likely at a slightly reduced vertical rate. Seismic characteristics appear empirically consistent with gradual earth material compaction/settling. ?? 2005 Society of Exploration Geophysicists.

Dissolution of bedded rock salt: A seismic profile across the active eastern margin of the Hutchinson Salt Member, central Kansas

USGS Publications Warehouse

Anderson, N.L.; Hopkins, J.; Martinez, A.; Knapp, R.W.; Macfarlane, P.A.; Watney, W.L.; Black, R.

1994-01-01

Since late Tertiary, bedded rock salt of the Permian Hutchinson Salt Member has been dissolved more-or-less continuously along its active eastern margin in central Kansas as a result of sustained contact with unconfined, undersaturated groundwater. The associated westward migration of the eastern margin has resulted in surface subsidence and the contemporaneous sedimentation of predominantly valley-filling Quarternary alluvium. In places, these alluvium deposits extend more than 25 km to the east of the present-day edge of the main body of contiguous rock salt. The margin could have receded this distance during the past several million years. From an environmental perspective, the continued leaching of the Hutchinson Salt is a major concern. This predominantly natural dissolution occurs in a broad zone across the central part of the State and adversely affects groundwater and surface-water quality as nonpoint source pollution. Significant surface subsidence occurs as well. Most of these subsidence features have formed gradually; others developed in a more catastrophic manner. The latter in particular pose real threats to roadways, railways, and buried oil and gas pipelines. In an effort to further clarify the process of natural salt dissolution in central Kansas and with the long-term goal of mitigating the adverse environmental affects of such leaching, the Kansas Geological Survey acquired a 4-km seismic profile across the eastern margin of the Hutchinson Salt in the Punkin Center area of central Kansas. The interpretation of these seismic data (and supporting surficial and borehole geologic control) is consistent with several hypotheses regarding the process and mechanisms of dissolution. More specifically these data support the theses that: 1. (1) Dissolution along the active eastern margin of the Hutchinson Salt Member was initiated during late Tertiary. Leaching has resulted in the steady westward migration of the eastern margin, surface subsidence, and the

Long-term evolution of Wink sinkholes in West Texas observed by high-resolution satellite imagery

NASA Astrophysics Data System (ADS)

Kim, J. W.; Lu, Z.

2016-12-01

Sinkhole is ground depression and/or collapse over the subsurface cavity in the karst terrain underlain by the carbonates, evaporites, and other soluble soils and rocks. The geohazards have been considered as a "hidden threat" to human life, infrastructures, and properties. The Delaware Basin of West Texas in the southwest part of the Permian Basin contains one of the greatest accumulations of evaporites in the United States. Sinkholes in West Texas have been developed by the dissolution of the subsurface evaporite deposits that come in contact with groundwater. Two Wink sinkholes in Wink, Texas, were developed in 1980 and 2002, respectively. However, monitoring the sinkholes in no man's lands has been challenging due to the lack of availability of high-resolution and temporally dense acquisitions. We employ aerial photography and radar satellite imagery to measure the long-term deformation from early 2000 and characterize the inherent hydrogeology that is closely related to sinkhole collapse and subsidence. Furthermore, data on oil/gas production and water injection into the subsurface as well as ground water level are analyzed to study their effects on the concurrent unstable ground surface in Wink sinkholes. Our study will provide invaluable information to understand the mechanism of sinkhole development and mitigate the catastrophic outcomes of the geohazards.

Evaluation, repair and stabilization of the boling sinkhole

NASA Astrophysics Data System (ADS)

Dreyer, Boyd V.; Schulz, Clyde E.

1986-03-01

Abrupt ground subsidence occurred along FM 442, approximately 3 miles east of Boling, in Wharton County, Texas, in August 1983 The subsidence created a depression of approximately 250 feet in diameter with a maximum depth of about 25 feet. Roadway collapse, pavement breakage, and inundation of the sinkhole by subsurface waters forced the closure of FM 442 to thru-traffic The vicinity of the sinkhole is underlain, by alluvial deposits of the Colorado River drainage basin and unconsolidated Miocene, Pliocene, and Pleistocene sediments to a depth of about 500 feet. The sediments consist largely of sand, silts, clays, and gravels. The Boling Salt Dome and its associated caprock occur directly beneath the section of unconsolidated sediments Major and minor axes of the dome are about 5 miles and 35 miles, respectively, and the sinkhole occurred approximately 1 mile east-northeast of the dome's center An investigation was conducted in the immediate area of the sinkhole to determine the cause of the subsidence and also to determine the feasibility of dewatering the sinkhole Four monitoring wells were installed around the perimeter to evaluate the potential recharge from shallow sand units Two 300-foot holes were drilled and geophysically logged to determine the stratigraphy adjacent to the sinkhole, and two slope indicators were installed in order to evaluate further earth movements A total of six million gallons of saline water were removed and disposed of from the sinkhole Based on information provided by the geologic and dewatering investigation, the Texas State Department of Highways and Public Transportation elected to fill the existing sinkhole and reconstruct the roadway A total of 3,500 cubic yards of rock borrow and 26,000 cubic yards of soil borrow were placed in the depression Construction began in February 1984, and the roadway was completed in May A monitoring program to evaluate subsequent earth movements will continue into 1985

Source Inversion of Seismic Events Associated with the Sinkhole at Napoleonville Salt Dome, Louisiana using a 3D Velocity Model

NASA Astrophysics Data System (ADS)

Nayak, Avinash; Dreger, Douglas S.

2018-05-01

The formation of a large sinkhole at the Napoleonville salt dome (NSD), Assumption Parish, Louisiana, caused by the collapse of a brine cavern, was accompanied by an intense and complex sequence of seismic events. We implement a grid-search approach to compute centroid locations and point-source moment tensor (MT) solutions of these seismic events using ˜0.1-0.3 Hz displacement waveforms and synthetic Green's functions computed using a 3D velocity model of the western edge of the NSD. The 3D model incorporates the currently known approximate geometry of the salt dome and the overlying anhydrite-gypsum cap rock, and features a large velocity contrast between the high velocity salt dome and low velocity sediments overlying and surrounding it. For each possible location on the source grid, Green's functions (GFs) to each station were computed using source-receiver reciprocity and the finite-difference seismic wave propagation software SW4. We also establish an empirical method to rigorously assess uncertainties in the centroid location, MW and source type of these events under evolving network geometry, using the results of synthetic tests with hypothetical events and real seismic noise. We apply the methods on the entire duration of data (˜6 months) recorded by the temporary US Geological Survey network. During an energetic phase of the sequence from 24-31 July 2012 when 4 stations were operational, the events with the best waveform fits are primarily located at the western edge of the salt dome at most probable depths of ˜0.3-0.85 km, close to the horizontal positions of the cavern and the future sinkhole. The data are fit nearly equally well by opening crack MTs in the high velocity salt medium or by isotropic volume-increase MTs in the low velocity sediment layers. We find that data recorded by 6 stations during 1-2 August 2012, right before the appearance of the sinkhole, indicate that some events are likely located in the lower velocity media just outside the

Geotechnical studies associated with decommissioning the strategic petroleum reserve facility at Weeks Island, Louisiana: A case history

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bauer, S.J.; Ehgartner, B.L.; Neal, J.T.

1997-05-01

The first sinkhole at the Weeks Island Strategic Petroleum Reserve (SPR) site was initially observed in May 1992. Concurrent with the increasing dissolution of salt over the mined oil storage area below, it has gradually enlarged and deepened. Beginning in 1994 and continuing to the present, the injection of saturated brine directly into the sinkhole throat some 76 m beneath the ground surface essentially arrested further dissolution, providing time to make adequate preparation for the safe and orderly transfer of crude oil to other storage facilities. This mitigation measure marked the first time that such a control procedure has beenmore » used in salt mining; previously all control has been achieved by either in-mine or from-surface grouting. A second and much smaller sinkhole was noticed in early 1995 on an opposite edge of the SPR mine, but with a very similar geological and mine mechanics setting. Both sinkholes occur where the edges of upper 152 m and lower 213 m mined storage levels are nearly vertically aligned. Such coincidence maximizes the tensional stress development, leading to fracturing in the salt. This cracking takes 20 or more years to develop. The cracks then become flow paths for brine incursion, which after time progress into the mined openings. Undersaturated ground water gradually enlarges the cracks in salt through dissolution, leading to eventual collapse of the overlying sand to form sinkholes. Other geologic conditions may also be secondary factors in controlling both mining extent and sinkhole location.« less

Nickel-plating for active metal dissolution resistance in molten fluoride salts

NASA Astrophysics Data System (ADS)

Olson, Luke; Sridharan, Kumar; Anderson, Mark; Allen, Todd

2011-04-01

Ni electroplating of Incoloy-800H was investigated with the goal of mitigating Cr dissolution from this alloy into molten 46.5%LiF-11.5%NaF-42%KF eutectic salt, commonly referred to as FLiNaK. Tests were conducted in graphite crucibles at a molten salt temperature of 850 °C. The crucible material graphite accelerates the corrosion process due to the large activity difference between the graphite and the alloy. For the purposes of providing a baseline for this study, un-plated Incoloy-800H and a nearly pure Ni-alloy, Ni-201 were also tested. Results indicate that Ni-plating has the potential to significantly improve the corrosion resistance of Incoloy-800H in molten fluoride salts. Diffusion of Cr from the alloy through the Ni-plating does occur and if the Ni-plating is thin enough this Cr eventually dissolves into the molten salt. The post-corrosion test microstructure of the Ni-plating, particularly void formation was also observed to depend on the plating thickness. Diffusion anneals in a helium environment of Ni-plated Incoloy-800H and an Fe-Ni-Cr model alloy were also investigated to understand Cr diffusion through the Ni-plating. Further enhancements in the efficacy of the Ni-plating as a protective barrier against Cr dissolution from the alloy into molten fluoride salts can be achieved by thermally forming a Cr 2O 3 barrier film on the surface of the alloy prior to Ni electroplating.

Reactive-transport modelling of gypsum dissolution in a coastal karst aquifer in Puglia, southern Italy

NASA Astrophysics Data System (ADS)

Campana, Claudia; Fidelibus, Maria Dolores

2015-11-01

The gypsum coastal aquifer of Lesina Marina (Puglia, southern Italy) has been affected by sinkhole formation in recent decades. Previous studies based on geomorphologic and hydrogeological data ascribed the onset of collapse phenomena to the erosion of material that fills palaeo-cavities (suffosion sinkholes). The change in the hydrodynamic conditions of groundwater induced by the excavation of a canal within the evaporite formation nearly 100 years ago was identified as the major factor in triggering the erosion, while the contribution of gypsum dissolution was considered negligible. A combined reactive-transport/density-dependent flow model was applied to the gypsum aquifer to evaluate whether gypsum dissolution rate is a dominant or insignificant factor in recent sinkhole formation under current hydrodynamic conditions. The conceptual model was first defined with a set of assumptions based on field and laboratory data along a two-dimensional transect of the aquifer, and then a density-dependent, tide-influenced flow model was set up and solved using the numerical code SEAWAT. Finally, the resulting transient flow field was used by the reactive multicomponent transport model PHT3D to estimate the gypsum dissolution rate. The validation tests show that the model accurately represents the real system, and the multi-disciplinary approach provides consistent information about the causes and evolution time of dissolution processes. The modelled porosity development rate is too low to represent a significant contribution to the recent sinkhole formation in the Lesina Marina area, although it justifies cavity formation and cavity position over geological time.

Electrochemical Dissolution of Tungsten Carbide in NaCl-KCl-Na2WO4 Molten Salt

NASA Astrophysics Data System (ADS)

Zhang, Liwen; Nie, Zuoren; Xi, Xiaoli; Ma, Liwen; Xiao, Xiangjun; Li, Ming

2018-02-01

Tungsten carbide was utilized as anode to extract tungsten in a NaCl-KCl-Na2WO4 molten salt, and the electrochemical dissolution was investigated. Although the molten salt electrochemical method is a short process method of tungsten extraction from tungsten carbide in one step, the dissolution efficiency and current efficiency are quite low. In order to improve the dissolution rate and current efficiency, the sodium tungstate was added as the active substance. The dissolution rate, the anode current efficiency, and the cathode current efficiency were calculated with different contents of sodium tungstate addition. The anodes prior to and following the reaction, as well as the product, were analyzed through X-ray diffraction, scanning electron microscopy, and energy dispersive spectrometry. The results demonstrated that the sodium tungstate could improve the dissolution rate and the current efficiency, due to the addition of sodium tungstate decreasing the charge transfer resistance in the electrolysis system. Due to the fact that the addition of sodium tungstate could remove the carbon during electrolysis, pure tungsten powders with 100 nm diameter were obtained when the content of sodium tungstate was 1.0 pct.

Photosensitive dissolution inhibitors and resists based on onium salt carboxylates

DOEpatents

Dentinger, Paul M.; Simison, Kelby L.

2005-11-29

A photoresist composition that employs onium salt carboxylates as thermally stable dissolution inhibitors. The photoresist composition can be either an onium carboxylate salt with a phenolic photoresist, such as novolac, or an onium cation protected carboxylate-containing resin such as an acrylic/acrylic acid copolymer. The onium carboxylate can be an onium cholate, wherein the onium cholate is an iodonium cholate. Particularly preferred iodonium cholates are alkyloxyphenylphenyl iodonium cholates and most particularly preferred is octyloxyphenyphenyl iodonium cholate. The photoresist composition will not create nitrogen or other gaseous byproducts upon exposure to radiation, does not require water for photoactivation, has acceptable UV radiation transmission characteristics, and is thermally stable at temperatures required for solvent removal.

Natural and human-induced sinkhole hazards in Saudi Arabia: distribution, investigation, causes and impacts

NASA Astrophysics Data System (ADS)

Youssef, Ahmed M.; Al-Harbi, Hasan M.; Gutiérrez, Francisco; Zabramwi, Yasser A.; Bulkhi, Ali B.; Zahrani, Saeed A.; Bahamil, Alaa M.; Zahrani, Ahmed J.; Otaibi, Zaam A.; El-Haddad, Bosy A.

2016-05-01

Approximately 60 % of the 2,150,000 km2 area of Saudi Arabia is underlain by soluble sediments (carbonate and evaporite rock formations, salt diapirs, sabkha deposits). Despite its hyper-arid climate, a wide variety of recent sinkholes have been reported in numerous areas, involving significant property losses. Human activities, most notably groundwater extraction, have induced unstable conditions on pre-existing cavities. This work provides an overview of the sinkhole hazard in Saudi Arabia, a scarcely explored topic. It identifies the main karst formations and the distribution of the most problematic sinkhole areas, illustrated through several case studies covering the wide spectrum of subsidence mechanisms. Some of the main investigation methods are presented through selected examples, including remote sensing, trenching and geophysics. Based on the available data, the main causal factors are identified and further actions that should be undertaken to better assess and manage the risk are discussed.

Groundwater flow and its effect on salt dissolution in Gypsum Canyon watershed, Paradox Basin, southeast Utah, USA

NASA Astrophysics Data System (ADS)

Reitman, Nadine G.; Ge, Shemin; Mueller, Karl

2014-09-01

Groundwater flow is an important control on subsurface evaporite (salt) dissolution. Salt dissolution can drive faulting and associated subsidence on the land surface and increase salinity in groundwater. This study aims to understand the groundwater flow system of Gypsum Canyon watershed in the Paradox Basin, Utah, USA, and whether or not groundwater-driven dissolution affects surface deformation. The work characterizes the groundwater flow and solute transport systems of the watershed using a three-dimensional (3D) finite element flow and transport model, SUTRA. Spring samples were analyzed for stable isotopes of water and total dissolved solids. Spring water and hydraulic conductivity data provide constraints for model parameters. Model results indicate that regional groundwater flow is to the northwest towards the Colorado River, and shallow flow systems are influenced by topography. The low permeability obtained from laboratory tests is inconsistent with field observed discharges, supporting the notion that fracture permeability plays a significant role in controlling groundwater flow. Model output implies that groundwater-driven dissolution is small on average, and cannot account for volume changes in the evaporite deposits that could cause surface deformation, but it is speculated that dissolution may be highly localized and/or weaken evaporite deposits, and could lead to surface deformation over time.

A remote sensing study of regional variation in sinkhole morphology-Florida karst vs. Minnesota karst

NASA Astrophysics Data System (ADS)

Ernst, C. L.; Hadizadeh, J.; McCarty, J. L.

2010-12-01

In many regions of the United States, database technologies and GIS have facilitated spatial analysis of karst. The purpose of this research was to compare regional latitudinal variation in sinkhole karst morphology via remote sensing techniques. Such comparison may be significant because the development of a karst landscape depends primarily on climate and availability of water as well as lithology. Sinkhole karst, a common karst in the U.S., is morphologically defined as cone-shaped depressions with circular or oval opening to the surface that result from the dissolution of relatively soluble bedrock such as limestone or gypsum. The two regions of interest, north-central Florida and southeastern Minnesota, were selected based on structural and lithological similarity of limestone bedrock and the fact that the bedrock study areas are located in clearly different climate zones. This approach utilized topographic maps, digital elevation models, state karst feature databases, and high resolution 0.6m QuickBirdTM and 0.5m WorldView 1TM satellite images in a GIS environment. Morphological parameters - area, perimeter, minor axis and major axis length - were calculated on a total of 80 sinkholes in the study regions using the zonal geometry function, a tool in the spatial analysis extension provided by ESRITM. Our results show that north-central Florida and southeastern Minnesota karst are statistically different in terms of sinkhole shape and size distribution. Florida has larger sinkholes (2,835 square meter Mean) that are closer to circular shape. Minnesota has smaller (1,213 square meter Mean) and more elliptical sinkholes with a comparatively shorter minor axis. Of the possible explanations, climate appears to be the most likely cause for the observed differences. The higher amount of precipitation in Florida coupled with warmer year round temperatures provides an environment conducive to a more chemically involved hydrological regime, which may be responsible for

Sinkholes

USGS Publications Warehouse

Kaufmann, James E.

2007-01-01

Sinkholes are a common feature in Missouri where limestone and dolomite outcrop. Though often considered a benign nuisance, sudden, catastrophic collapses can destroy property, delay construction projects, and contaminate ground water resources.

Sinkhole flooding in Murfreesboro, Rutherford County, Tennessee, 2001-02

USGS Publications Warehouse

Bradley, Michael W.; Hileman, Gregg Edward

2006-01-01

The U.S. Geological Survey, in cooperation with the City of Murfreesboro, Tennessee, conducted an investigation from January 2001 through April 2002 to delineate sinkholes and sinkhole watersheds in the Murfreesboro area and to characterize the hydrologic response of sinkholes to major rainfall events. Terrain analysis was used to define sinkholes and delineate the sinkhole drainage areas. Flooding in 78 sinkholes in three focus areas was identified and tracked using aerial photography following three major storms in February 2001, January 2002, and March 2002. The three focus areas are located to the east, north, and northwest of Murfreesboro and are underlain primarily by the Ridley Limestone with some outcrops of the underlying Pierce Limestone. The observed sinkhole flooding is controlled by water inflow, water outflow, and the degree of the hydraulic connection (connectivity) to a ground-water conduit system. The observed sinkholes in the focus areas are grouped into three categories based on the sinkhole morphology and the connectivity to the ground-water system as indicated by their response to flooding. The three types of sinkholes described for these focus areas are pan sinkholes with low connectivity, deep sinkholes with high connectivity, and deep sinkholes with low connectivity to the ground-water conduit system. Shallow, broad pan sinkholes flood as water inflow from a storm inundates the depression at land surface. Water overflow from one pan sinkhole can flow downgradient and become inflow to a sinkhole at a lower altitude. Land-surface modifications that direct more water into a pan sinkhole could increase peak-flood altitudes and extend flood durations. Land-surface modifications that increase the outflow by overland drainage could decrease the flood durations. Road construction or alterations that reduce flow within or between pan sinkholes could result in increased flood durations. Flood levels and durations in the deeper sinkholes observed in

SH-wave reflection seismic and VSP as tools for the investigation of sinkhole areas in Germany

NASA Astrophysics Data System (ADS)

Wadas, Sonja; Tschache, Saskia; Polom, Ulrich; Buness, Hermann; Krawczyk, Charlotte M.

2017-04-01

Sinkholes can lead to damage of buildings and infrastructure and they can cause life-threatening situations, if they occur in urban areas. The process behind this phenomenon is called subrosion. Subrosion is the underground leaching of soluble rocks, e.g. anhydrite and gypsum, due to the contact with ground- and meteoric water. Depending on the leached material, and especially the dissolution rate, different kinds of subrosion structures evolve in the subsurface. The two end members are collapse and depression structures. For a better understanding of the subrosion processes a detailed characterization of the resulting structures is necessary. In Germany sinkholes are a problem in many areas. In northern Germany salt and in central and southern Germany sulfate and carbonate deposits are affected by subrosion. The study areas described here are located in Thuringia in central Germany and the underground is characterized by soluble Permian deposits. The occurrence of 20 to 50 sinkholes is reported per year. Two regions, Bad Frankenhausen and Schmalkalden, are investigated, showing a leaning church tower and a sinkhole of 30 m diameter and 20 m depth, respectively. In Bad Frankenhausen four P-wave and 16 SH-wave reflection seismic profiles were carried out, supplemented by three zero-offset VSPs. In Schmalkalden five SH-wave reflection seismic profiles and one zero-offset VSP were acquired. The 2-D seismic sections, in particular the SH-wave profiles, showed known and unknown near-surface faults in the vicinity of sinkholes and depressions. For imaging the near-surface (< 100 m depth) high-resolution SH-waves are advantageous in order to detect subrosion structures at different stages. The reflection patterns of the 2-D seismic sections indicate a heterogeneous underground with lateral and vertical variations in forms of discontinuous reflectors, depressions, small-scale fractures and near-surface faults. Probably the faults and fractures serve as pathways for

Advances in detecting localized road damage due to sinkholes induced by engineering works using high resolution RASARSAT-2 data

NASA Astrophysics Data System (ADS)

Chen, J.; Zebker, H. A.; Lakshmi, V.

2016-12-01

Sinkholes often occur in karst terrains such as found in central and eastern Pennsylvania. Voids produced by dissolution of carbonate rocks can result in soil transport leading to localized, gradual or rapid, sinking of the land surface. A cluster of sinkholes developed in 2000 around a small rural community beside Bushkill creek near a limestone quarry, and severely destroyed road bridges and railway tracks. At a cost of $6 million, the Pennsylvania DoT replaced the bridge, which was damaged again in 2004 by newly developed sinkholes likely associated with quarry's pumping activity. Here we present high-resolution spaceborne interferometric radar images of sinkhole development on this community. We show that this technique may be used to monitor regions with high sinkhole damage risk and assist future infrastructure route planning, especially in rural areas where hydrogeologic information is limited. Specifically, we processed 66 RADARSAT-2 interferograms to extract deformation occurred over Bushkill creek between Jun. 2015 and Mar. 2016 with a temporal resolution of 24 days. We advanced recent persistent scatterer techniques to preserve meter-level spatial resolution in the interferograms while minimizing temporal decorrelation and phase unwrapping error. We observe periodic deformation due to pumping activity at the quarry and localized subsidence along Bushkill creek that is co-located with recent reported sinkholes. We plan to use the automatic processing techniques developed for this study to study road damage in another region in Pennsylvania, along Lewiston Narrows, and also to monitor urban infrastructure improvements in Seattle, both again with RASARSAT-2 data. Our results demonstrate that recent advances in satellite geodesy can be transferred to benefit society beyond the science community.

Sinkholes, subsidence and subrosion on the eastern shore of the Dead Sea as revealed by a close-range photogrammetric survey

NASA Astrophysics Data System (ADS)

Al-Halbouni, Djamil; Holohan, Eoghan P.; Saberi, Leila; Alrshdan, Hussam; Sawarieh, Ali; Closson, Damien; Walter, Thomas R.; Dahm, Torsten

2017-05-01

Ground subsidence and sinkhole collapse are phenomena affecting regions of karst geology worldwide. The rapid development of such phenomena around the Dead Sea in the last four decades poses a major geological hazard to the local population, agriculture and industry. Nonetheless many aspects of this hazard are still incompletely described and understood, especially on the eastern Dead Sea shore. In this work, we present a first low altitude (< 150 m above ground) aerial photogrammetric survey with a Helikite Balloon at the sinkhole area of Ghor Al-Haditha, Jordan. We provide a detailed qualitative and quantitative analysis of a new, high resolution digital surface model (5 cm px-1) and orthophoto of this area (2.1 km2). We also outline the factors affecting the quality and accuracy of this approach. Our analysis reveals a kilometer-scale sinuous depression bound partly by flexure and partly by non-tectonic faults. The estimated minimum volume loss of this subsided zone is 1.83 ṡ 106 m3 with an average subsidence rate of 0.21 m yr-1 over the last 25 years. Sinkholes in the surveyed area are localized mainly within this depression. The sinkholes are commonly elliptically shaped (mean eccentricity 1.31) and clustered (nearest neighbor ratio 0.69). Their morphologies and orientations depend on the type of sediment they form in: in mud, sinkholes have a low depth to diameter ratio (0.14) and a long-axis azimuth of NNE-NE. In alluvium, sinkholes have a higher ratio (0.4) and are orientated NNW-N. From field work, we identify actively evolving artesian springs and channelized, sediment-laden groundwater flows that appear locally in the main depression. Consequently, subrosion, i.e. subsurface mechanical erosion, is identified as a key physical process, in addition to dissolution, behind the subsidence and sinkhole hazard. Furthermore, satellite image analysis links the development of the sinuous depression and sinkhole formation at Ghor Al-Haditha to preferential

Railway deformation detected by DInSAR over active sinkholes in the Ebro Valley evaporite karst, Spain

NASA Astrophysics Data System (ADS)

Galve, J. P.; Castañeda, C.; Gutiérrez, F.

2015-11-01

Subsidence was measured for the first time on railway tracks in the central sector of Ebro Valley (NE Spain) using Differential Synthetic Aperture Radar Interferometry (DInSAR) techniques. This area is affected by evaporite karst and the analysed railway corridors traverse active sinkholes that produce deformations in these infrastructures. One of the railway tracks affected by slight settlements is the Madrid-Barcelona high-speed line, a form of transport infrastructure highly vulnerable to ground deformation processes. Our analysis based on DInSAR measurements and geomorphological surveys indicates that this line shows dissolution-induced subsidence and compaction of anthropogenic deposits (infills and embankments). Significant sinkhole-related subsidence was also measured by DInSAR techniques on the Castejón-Zaragoza conventional railway line. This study demonstrates that DInSAR velocity maps, coupled with detailed geomorphological surveys, may help in the identification of the railway track sections that are affected by active subsidence.

Sinkhole occurrence in consequence of heavy rainstorms

NASA Astrophysics Data System (ADS)

Parise, Mario; Pisano, Luca; Vennari, Carmela

2016-04-01

Sinkholes, the most typical geological hazard in karst, are widespread in Apulia (south-eastern Italy), due to the presence in about the whole region of soluble rocks. Sinkholes can cause damage to private property and civil infrastructures such as buildings and roads. Detailed mapping of sinkholes is critical in understanding the hydrological processes, beside being extremely useful to mitigate the related geological risk. Sinkholes typically function as a major connection between the water flowing at the surface and the groundwaters, by collecting rainfall and rapidly draining it within the bedrock. In Apulia, the main risk to the humans is generally linked to anthropogenic sinkholes, with the possibility of collapses related to man-made caves (quarries, mines, civil settlements, etc.; see Parise, 2012, 2015a). Natural sinkholes are less frequent, or appears at least to be less reported, since they generally occur in rural areas, and often are rapidly canceled by landowners. During the first week of September 2014, the Gargano Promontory (northern Apulia) was affected by an intense storm, characterized by rainfall cumulates well above the seasonal mean values. The total amount of measured rainfall for the whole event (covering the period from September 1, to September 6, 2014) reached a peak of over 500 mm (Martinotti et al., 2015). As a response to the storm, and due to peculiarity of the Gargano karst setting, several geo-hazards (different types of slope failures, floods and sinkholes) were recorded over an area of 2300 km2. As regards sinkholes, during the September 2014 storm, at least a dozen of phenomena, mostly of small size, were documented. These are prevailingly concentrated in two areas in the surroundings of the towns of San Marco in Lamis and Monte Sant'Angelo. In particular, at San Marco in Lamis, four sinkholes (the deepest about 6 m-deep and 5 m-wide, showing at the bottom the upper portion of the epikarst, with pinnacles of limestone rocks

A 300m-width sinkhole threatens the stability of the embankment of a saltpan in Jordan, Dead Sea Region

NASA Astrophysics Data System (ADS)

Closson, Damien; Abou Karaki, Najib; Pasquali, Paolo; Riccardi, Paolo

2013-04-01

Since the 1980s, the Dead Sea coastal zone is affected by sinkholes. The dynamic of the salt karst system is attested by a drastic increase of collapse events. The energy available for sub-surface erosion (or cavities genesis) is related to the head difference between the water table and the lake level which drop down at an accelerating rate of more than 1 m/yr. In the region of Ghor Al Haditha, Jordan, the size of the craters increased significantly during the last decade. Up to now, the greatest compound structure observed (association of metric subsidence, decametric sinkholes, and landslides) was about 150-200 m in diameter. End of December 2012, a single circular structure having 250-300 m in diameter was identified within a 10 km x 1.5 km saltpan of the Arab Potash Company. This finding raises questions regarding the origin of the underlying cavity and the capability of prediction of all models developed up to now in Israel and Jordan regarding the Dead Sea sinkholes. The analysis of satellite images of the past shows that the appearance of this unique depression is very recent (probably less than 5 years). Cosmo-SkyMed radar images have been processed to map the associated deformation field. Ground motions attest that the overall diameter could be around 600 m. Currently, this sinkhole is threatening the stability of more than one kilometer of a 12 km long dike holding 90 million m3 of Dead Sea brine. This case study underlines the great fragility of the Dead Sea salt karst and demonstrates the need for the setting up of an early warning system.

Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid - Case Study of GDC-0810.

PubMed

Hou, Hao Helen; Jia, Wei; Liu, Lichuan; Cheeti, Sravanthi; Li, Jane; Nauka, Ewa; Nagapudi, Karthik

2018-01-29

The purpose of this work is to investigate the effect of microenvironmental pH modulation on the in vitro dissolution rate and oral absorption of GDC-0810, an oral anti-cancer drug, in human. The pH-solubility profile of GDC-0810 free acid and pH max of its N-Methyl-D-glucamine (NMG) salt were determined. Precipitation studies were conducted for GDC-0810 NMG salt at different pH values. GDC-0810 200-mg dose NMG salt tablet formulations containing different levels of sodium bicarbonate as the pH modifier were tested for dissolution under the dual pH-dilution scheme. Three tablet formulations were evaluated in human as a part of a relative bioavailability study. A 200-mg dose of GDC-0810 was administered QD with low fat food. Intrinsic solubility of GDC-0810 free acid was found to be extremely low. The pH max of the NMG salt suggested a strong tendency for form conversion to the free acid under GI conditions. In vitro dissolution profiles showed that the dissolution rate and extent of GDC-0810 increased with increasing the level of sodium bicarbonate in the formulation. The human PK data showed a similar trend for the geometric mean of C max and AUC 0-t for formulations containing 5%, 10%, and 15% sodium bicarbonate, but the difference is not statistically significant. Incorporation of a basic pH modifier, sodium bicarbonate, in GDC-0810 NMG salt tablet formulations enhanced in vitro dissolution rate of GDC-0810 via microenvironmental pH modulation. The human PK data showed no statistically significant difference in drug exposure from tablets containing 5%, 10%, and 15% sodium bicarbonate.

Railway deformation detected by DInSAR over active sinkholes in the Ebro Valley evaporite karst, Spain

NASA Astrophysics Data System (ADS)

Galve, J. P.; Castañeda, C.; Gutiérrez, F.

2015-06-01

Previously not measured subsidence on railway tracks was detected using DInSAR displacement maps produced for the central sector of Ebro Valley (NE Spain). This area is affected by evaporite karst and the analyzed railway corridors traverse active sinkholes that produce deformations in these infrastructures. One of the railway tracks affected by slight settlements corresponds to the Madrid-Barcelona high-speed line, a transport infrastructure highly vulnerable to ground deformation processes. Our analysis based on DInSAR measurements and geomorphological surveys indicate that this line show dissolution-induced subsidence and compaction of anthropogenic deposits (infills and embankments). By using DInSAR techniques, it was also measured the significant subsidence related to the activity of sinkholes in the Castejón-Zaragoza conventional railway line. Thus, this study demonstrate that DInSAR velocity maps coupled with detailed geomorphological surveys may help in the identification of the sectors of railway tracks that may compromise the safety of travellers.

Seismic reflection characteristics of naturally-induced subsidence affecting transportation

USGS Publications Warehouse

Miller, R.D.; Xia, J.; Steeples, D.W.

2009-01-01

High-resolution seismic reflections have been used effectively to investigate sinkholes formed from the dissolution of a bedded salt unit found throughout most of Central Kansas. Surface subsidence can have devastating effects on transportation structures. Roads, rails, bridges, and pipelines can even be dramatically affected by minor ground instability. Areas susceptible to surface subsidence can put public safety at risk. Subsurface expressions significantly larger than surface depressions are consistently observed on seismic images recorded over sinkholes in Kansas. Until subsidence reaches the ground surface, failure appears to be controlled by compressional forces evidenced by faults with reverse orientation. Once a surface depression forms or dissolution of the salt slows or stops, subsidence structures are consistent with a tensional stress environment with prevalent normal faults. Detecting areas of rapid subsidence potential, prior to surface failure, is the ultimate goal of any geotechnical survey where the ground surface is susceptible to settling. Seismic reflection images have helped correlate active subsidence to dormant paleofeatures, project horizontal growth of active sinkholes based on subsurface structures, and appraise the risk of catastrophic failure. ?? China University of Geosciences (Wuhan) and Springer-Verlag GmbH 2009.

Rome: sinkhole events and network of underground cavities (Italy)

NASA Astrophysics Data System (ADS)

Nisio, Stefania; Ciotoli, Giancarlo

2016-04-01

The anthropogenic sinkholes in the city of Rome are closely linked to the network of underground cavities produced by human activities in more than two thousand years of history. Over the past fifteen years the increased frequency of intense rainfall events, favors sinkhole formation. The risk assessment induced by anthropogenic sinkhole is really difficult. However, a susceptibility of the territory to sinkholes can be more easily determined as the probability that an event may occur in a given space, with unique geological-morphological characteristics, and in an infinite time. A sinkhole susceptibility map of the Rome territory, up to the ring road, has been constructed by using Geographically Weighted Regression technique and geostatistics. The spatial regression model includes the analysis of more than 2700 anthropogenic sinkholes (recorded from 1875 to 2015), as well as geological, morphological, hydrological and predisposing anthropogenic characteristics of the study area. The numerous available data (underground cavities, the ancient entrances to the quarry, bunkers, etc.) facilitate the creation of a series of maps. The density map of the cavity, updated to 2015, showed that more than 20 km2 of the Roman territory are affected by underground cavities. The census of sinkholes (over 2700) shows that over 30 km2 has been affected by sinkholes. The final susceptibility map highlights that inside the Ring Road about 40 km2 of the territory (about 11%) have a very high probability of triggering a sinkhole event. The susceptibility map was also compared with the data of ground subsidence (InSAR) to obtain a predictive model.

Anthropogenic sinkholes in the town of Naples

NASA Astrophysics Data System (ADS)

Vennari, Carmela; Parise, Mario

2016-04-01

The importance of sinkhole as a natural hazard is often underrated when compared with landslides, floods, volcanic eruptions and earthquakes in Italy. Sinkholes are rarely included in risk analysis despite their frequent occurrence in several parts of Italy, especially in karst lands or in those sectors of the country where artificial cavities have been realized underground by man for different purposes. Among the most affected Italian regions, Campania (southern Italy) stands out for several reasons, with particular regard to the town of Naples, highly affected by anthropogenic sinkholes. These latter have caused serious damage to society, and above all to people in terms of deaths, missing persons, and injured people, due to the high urbanization of the city, developed above a complex and extensive network of cavities, excavated during the 2000 years of history of the town. Among the different typologies of artificial cavities, it is worth mentioning the high number of ancient quarry used to extract the building materials for the town construction. The Institute of Research for the Hydrological Protection (IRPI) of the National Research Council of Italy (CNR) has been working in the last years at populating a specific chronological database on sinkholes in the whole Italian country. On the base of the collected data, Naples appears to have been affected by not less than 250 events from the beginning of the century to nowadays. The IRPI database includes only sinkholes for which a temporal reference on their time of occurrence is known. Particular attention was given on this information, since the catalogue idea is to make a starting point for a complete sinkhole hazard analysis. At this aim, knowledge of the time of occurrence is mandatory. Day, month and year of the event are known for about 70% of sinkholes that took place in Naples, but the hour of occurrence is known for just 6% of the data. Information about site of occurrence are, on the other hand, highly

Quantifying potential recharge in mantled sinkholes using ERT.

PubMed

Schwartz, Benjamin F; Schreiber, Madeline E

2009-01-01

Potential recharge through thick soils in mantled sinkholes was quantified using differential electrical resistivity tomography (ERT). Conversion of time series two-dimensional (2D) ERT profiles into 2D volumetric water content profiles using a numerically optimized form of Archie's law allowed us to monitor temporal changes in water content in soil profiles up to 9 m in depth. Combining Penman-Monteith daily potential evapotranspiration (PET) and daily precipitation data with potential recharge calculations for three sinkhole transects indicates that potential recharge occurred only during brief intervals over the study period and ranged from 19% to 31% of cumulative precipitation. Spatial analysis of ERT-derived water content showed that infiltration occurred both on sinkhole flanks and in sinkhole bottoms. Results also demonstrate that mantled sinkholes can act as regions of both rapid and slow recharge. Rapid recharge is likely the result of flow through macropores (such as root casts and thin gravel layers), while slow recharge is the result of unsaturated flow through fine-grained sediments. In addition to developing a new method for quantifying potential recharge at the field scale in unsaturated conditions, we show that mantled sinkholes are an important component of storage in a karst system.

The Macungie sinkhole, Lehigh Valley, Pennsylvania: Cause and repair

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dougherty, P.H.; Perlow, M. Jr.

1988-10-01

A dramatic sinkhole collapse measuring some 100 feet in diameter by 41 feet deep occurred suddenly in the Borough of Macungie on June 23, 1986. The sinkhole collapse resulted in a major health and safety hazard. Continual growth of the sinkhole could have resulted in almost certain damage or loss to more than 17 residences adjacent to the sinkhole collapse. Stabilization and repair costs totaled some $450,000 and required almost three months to restore utility services, roadway, and parking areas.

Log analysis of six boreholes in conjunction with geologic characterization above and on top of the Weeks Island Salt Dome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sattler, A.R.

1996-06-01

Six boreholes were drilled during the geologic characterization and diagnostics of the Weeks Island sinkhole that is over the two-tiered salt mine which was converted for oil storage by the U.S. Strategic Petroleum Reserve. These holes were drilled to provide for geologic characterization of the Weeks Island Salt Dome and its overburden in the immediate vicinity of the sinkhole (mainly through logs and core); to establish a crosswell configuration for seismic tomography; to establish locations for hydrocarbon detection and tracer injection; and to provide direct observations of sinkhole geometry and material properties. Specific objectives of the logging program were to:more » (1) identify the top of and the physical state of the salt dome; (2) identify the water table; (3) obtain a relative salinity profile in the aquifer within the alluvium, which ranges from the water table directly to the top of the Weeks Island salt dome; and (4) identify a reflecting horizon seen on seismic profiles over this salt dome. Natural gamma, neutron, density, sonic, resistivity and caliper logs were run.« less

Log analysis of six boreholes in conjunction with geologic characterization above and on top of the Weeks Island salt dome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sattler, A.R.

1996-04-01

Six boreholes were drilled during the geologic characterization and diagnostics of the Weeks Island sinkhole that is over the two-tiered salt mine which was converted for oil storage by the US Strategic Petroleum Reserve. These holes were drilled to provide for geologic characterization of the Weeks Island Salt Dome and its overburden in the immediate vicinity of the sinkhole (mainly through logs and core); to establish a crosswell configuration for seismic tomography; to establish locations for hydrocarbon detection and tracer injection; and to Provide direct observations of sinkhole geometry and material properties. Specific objectives of the logging program were to:more » (1) identify the top of and the physical state of the salt dome; (2) identify the water table; (3) obtain a relative salinity profile in the aquifer within the alluvium, which ranges from the water table directly to the top of the Weeks Island salt dome; and (4) identify a reflecting horizon seen on seismic profiles over this salt dome. Natural gamma, neutron, density, sonic, resistivity and caliper logs were run. Neutron and density logs were run from inside the well casing because of the extremely unstable condition of the deltaic alluvium overburden above the salt dome. The logging program provided important information about the salt dome and the overburden in that (1) the top of the salt dome was identified at {approximately}189 ft bgl (103 ft msl), and the top of the dome contains relatively few fractures; (2) the water table is approximately 1 ft msl, (3) this aquifer appears to become steadily more saline with depth; and (4) the water saturation of much of the alluvium over the salt dome is shown to be influenced by the prevalent heavy rainfall. This logging program, a part of the sinkhole diagnostics, provides unique information about this salt dome and the overburden.« less

Comparison of a new GIS-based technique and a manual method for determining sinkhole density: An example from Illinois' sinkhole plain

USGS Publications Warehouse

Angel, J.C.; Nelson, D.O.; Panno, S.V.

2004-01-01

A new Geographic Information System (GIS) method was developed as an alternative to the hand-counting of sinkholes on topographic maps for density and distribution studies. Sinkhole counts were prepared by hand and compared to those generated from USGS DLG data using ArcView 3.2 and the ArcInfo Workstation component of ArcGIS 8.1 software. The study area for this investigation, chosen for its great density of sinkholes, included the 42 public land survey sections that reside entirely within the Renault Quadrangle in southwestern Illinois. Differences between the sinkhole counts derived from the two methods for the Renault Quadrangle study area were negligible. Although the initial development and refinement of the GIS method required considerably more time than counting sinkholes by hand, the flexibility of the GIS method is expected to provide significant long-term benefits and time savings when mapping larger areas and expanding research efforts. ?? 2004 by The National Speleological Society.

Simultaneous enhancements of solubility and dissolution rate of poorly water-soluble febuxostat via salts

NASA Astrophysics Data System (ADS)

Zhang, Xian-Rui; Zhang, Lei

2017-06-01

Novel crystalline forms of febuxostat (HFEB) salts were synthesized by liquid-assisted cogrinding with 2-methylimidazole (2MI) and di-2-pyridylamine (DPA) and characterized by Hirshfeld surface analysis, IR, 1H NMR, single crystal and powder X-ray diffractions, TGA and DSC. Two new HFEB salts featured different stoichiometries: 2:1 molecular ratio in HFEB-2MI and 1:1 molecular ratio in HFEB-DPA. For HFEB-2MI salt, two HFEB molecules lost one proton forming a singly charged hydrogen carboxylate anion H(FEB)2-, which interacted with the disordered 2MI cation via the N3sbnd H3A⋯O1i (i: -x, -y, -z+1) and N4sbnd H4B⋯O1ii (ii: x, y+1, z-1) hydrogen bonds to form one-dimensional structure. For HFEB-DPA salt, one proton transferred from one HFEB to DPA, which were further connected by N4sbnd H1⋯O1 and N3sbnd H2⋯O2 hydrogen bonds to form an R22(8) ring motif. HFEB-2MI and HFEB-DPA salts exhibited increased equilibrium solubilities and intrinsic dissolution rates compared to those of HFEB in aqueous medium.

NASA Radar Demonstrates Ability to Foresee Sinkholes

NASA Image and Video Library

2014-03-06

Analyses by NASA UAVSAR radar performed after the Bayou Corne, La., sinkhole formed, show it was able to detect precursory ground surface movement of up to 10.2 inches 260 millimeters more than a month before the sinkhole collapsed in Aug. 2012.

InSAR Measurement of Precursor and Post-Collapse Sinkhole Subsidence

NASA Astrophysics Data System (ADS)

Holley, Rachel; McCormack, Harry; Larkin, Hayley; Wooster, Michael; Thomas, Adam

2016-08-01

Sinkholes occur across the world, often posing an obvious hazard to communities, infrastructure and the environment. Regions prone to sinkhole formation can often be identified; however prediction of exact sinkhole locations and occurrences is exceedingly difficult. This case study from Wink, in the Permian Basin of Texas, demonstrates how InSAR can measure both precursor and post-collapse deformation associated with sinkholes. ERS, ALOS PALSAR and Sentinel-1A datasets are used to show precursor signals at least nine years before sinkhole formation, and post-collapse effects continuing over several decades. The rate of deformation is variable, but reaches many tens of centimetres per year during some periods.

Mapping and predicting sinkholes by integration of remote sensing and spectroscopy methods

NASA Astrophysics Data System (ADS)

Goldshleger, N.; Basson, U.; Azaria, I.

2013-08-01

The Dead Sea coastal area is exposed to the destructive process of sinkhole collapse. The increase in sinkhole activity in the last two decades has been substantial, resulting from the continuous decrease in the Dead Sea's level, with more than 1,000 sinkholes developing as a result of upper layer collapse. Large sinkholes can reach 25 m in diameter. They are concentrated mainly in clusters in several dozens of sites with different characteristics. In this research, methods for mapping, monitoring and predicting sinkholes were developed using active and passive remote-sensing methods: field spectrometer, geophysical ground penetration radar (GPR) and a frequency domain electromagnetic instrument (FDEM). The research was conducted in three stages: 1) literature review and data collection; 2) mapping regions abundant with sinkholes in various stages and regions vulnerable to sinkholes; 3) analyzing the data and translating it into cognitive and accessible scientific information. Field spectrometry enabled a comparison between the spectral signatures of soil samples collected near active or progressing sinkholes, and those collected in regions with no visual sign of sinkhole occurrence. FDEM and GPR investigations showed that electrical conductivity and soil moisture are higher in regions affected by sinkholes. Measurements taken at different time points over several seasons allowed monitoring the progress of an 'embryonic' sinkhole.

Sinkhole Susceptibility Analysis for Karapinar/konya via Multi Criteria Decision

NASA Astrophysics Data System (ADS)

Sarı, F.

2017-11-01

Sinkholes are being a natural hazard which threads economic and human life. Sudden occurrence characteristic of sinkholes make it unable to escape. There are a lot of factor that activate sinkholes such as geology, irrigation, land use and human related factors. In Karapınar, Konya, there are over 200 sinkholes and this count is getting increased in recent years. Especially active agricultural lands, decreasing ground water level, extreme irrigation by 55267 water wells increase the risk factor of Karapınar. Nowadays, considering the economic contribution of Karapınar to Turkey economy in the field of agriculture, solar energy fields and thermal reactor which will be planned in next few years, prediction of sinkholes and searching for preventation ways are being more important issue. In this study, sinkhole susceptibility map via AHP was carried out for Karapınar in Konya. Slope, land use, elevation, geology, water wells, distance to roads and settlements criteria are included to determine susceptibility. The weights are calculated with AHP for each criterion and generated susceptibility map is overlapped with existing sinkholes. Suggestions and results are shared for this study.

Evaporite-karst problems and studies in the USA

USGS Publications Warehouse

Johnson, K.S.

2008-01-01

Evaporites, including rock salt (halite) and gypsum (or anhydrite), are the most soluble among common rocks; they dissolve readily to form the same types of karst features that commonly are found in limestones and dolomites. Evaporites are present in 32 of the 48 contiguous states in USA, and they underlie about 40% of the land area. Typical evaporite-karst features observed in outcrops include sinkholes, caves, disappearing streams, and springs, whereas other evidence of active evaporite karst includes surface-collapse structures and saline springs or saline plumes that result from salt dissolution. Many evaporites also contain evidence of paleokarst, such as dissolution breccias, breccia pipes, slumped beds, and collapse structures. All these natural karst phenomena can be sources of engineering or environmental problems. Dangerous sinkholes and caves can form rapidly in evaporite rocks, or pre-existing karst features can be reactivated and open up (collapse) under certain hydrologic conditions or when the land is put to new uses. Many karst features also propagate upward through overlying surficial deposits. Human activities also have caused development of evaporite karst, primarily in salt deposits. Boreholes (petroleum tests or solution-mining operations) or underground mines may enable unsaturated water to flow through or against salt deposits, either intentionally or accidentally, thus allowing development of small to large dissolution cavities. If the dissolution cavity is large enough and shallow enough, successive roof failures can cause land subsidence and/or catastrophic collapse. Evaporite karst, natural and human-induced, is far more prevalent than is commonly believed. ?? 2007 Springer-Verlag.

Characterizing the Weeks Island Salt Dome drilling of and seismic measurements from boreholes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sattler, A.R.; Harding, R.S.; Jacobson, R.D.

1996-10-01

A sinkhole 36 ft across, 30 ft deep was first observed in the alluvium over the Weeks Island Salt Dome (salt mine converted for oil storage by US Strategic Petroleum Reserve) May 1992. Four vertical, two slanted boreholes were drilled for diagnostics. Crosswell seismic data were generated; the velocity images suggest that the sinkhole collapse is complicated, not a simple vertical structure. The coring operation was moderately difficult; limited core was obtained through the alluvium, and the quality of the salt core from the first two vertical wells was poor. Core quality improved with better bit selection, mud, and drillingmore » method. The drilling fluid program provided fairly stable holes allowing open hole logs to be run. All holes were cemented successfully (although it took 3 attempts in one case).« less

Wink Sink

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baumgardner, R.W. Jr.

1988-01-01

The Wink Sink formed on June 3, l980. Inferred precursor of the sinkhole was a solution cavity in the Permian Salado Formation formed either by natural dissolution or by water flow in an abandoned oil well. Correlation of well logs in the area indicates that the Salado Formation contains several dissolution zones. Dissolution in the middle of the Salado evaporite sequence may have resulted from ground-water flow along fractured anhydrite interbeds. The Wink Sink lies directly above the Permian Capitan reef on the margin of a natural salt dissolution trough. Other natural collapse features overlie the reef to the north.more » Hydraulic head of water in the reef is higher than the elevation of the Salado Formation but lower than the head in the Triassic Santa Rosa Sandstone, a near-surface freshwater aquifer. Fracture or cavernous permeability occurs above, within, and below the Salado Formation. Consequently, a brine-density flow may be operating: relatively fresh water moves upward through fractures under artesian pressure and dissolves salt; the denser brine moves downward under gravity flow. Alternatively, downward flow of water from freshwater aquifers above the salt may have caused dissolution. An oil well drilled into the Permian Yates Formation (with the aid of nitroglycerine) in 1928 was located within the sinkhole. The well initially produced about 80% saline water from the Permian Tansill Formation, which directly underlies the Salado. About 600 ft of casing was removed from the well when it was plugged and abandoned in 1964.« less

Dissolution and subsequent re-crystallization as zeroing mechanism, thermal properties and component resolved dose response of salt (NaCl) for retrospective dosimetry.

PubMed

Polymeris, George S; Kitis, George; Kiyak, Nafiye G; Sfamba, Ioanna; Subedi, Bhagawan; Pagonis, Vasilis

2011-09-01

In the present study we report dosimetric properties of iodized salt aiming at using it as an accidental luminescent dosimeter. It was found that the very good sensitivity of its main dosimetric peak is strongly affected by thermal treatments. This is also the case for OSL emission. The sensitivity loss due to heating implies that caution should be exercised while applying single aliquot protocols for dose evaluation. The sequence of dissolution and subsequent re-crystallization was established to be an extremely effective zeroing mechanism for the TL signal. The linearity in the dose response was also monitored in the case of dissolved and subsequently re-crystallized salt. In the case of naturally occurring salt, zeroing of the TL signal due to dissolution as well as the linearity of dose response up to doses as large as 100 Gy were found to be very promising features for dating applications. Copyright © 2011 Elsevier Ltd. All rights reserved.

A thermodynamic description for water, hydrogen fluoride and hydrogen dissolutions in cryolite-base molten salts.

PubMed

Wang, Kun; Chartrand, Patrice

2018-06-15

This paper presents a quantitative thermodynamic description for water, hydrogen fluoride and hydrogen dissolutions in cryolite-base molten salts, which is of technological importance to the Hall-Héroult electrolytic aluminum extraction cell. The Modified Quasichemical Model in the Quadruplet Approximation (MQMQA), as used to treat a large variety of molten salt systems, was adopted to thermodynamically describe the present liquid phase; all solid solutions were modeled using the Compound Energy Formalism (CEF); the gas phase was thermodynamically treated as an ideal mixture of all possible species. The model parameters were mainly obtained by critical evaluations and optimizations of thermodynamic and phase equilibrium data available from relative experimental measurements and theoretical predictions (first-principles calculations and empirical estimations) for the lower-order subsystems. These optimized model parameters were thereafter merged within the Kohler/Toop interpolation scheme, facilitating the prediction of gas solubility (H2O, HF and H2) in multicomponent cryolite-base molten salts using the FactSage thermochemical software. Several interesting diagrams were finally obtained in order to provide useful information for the industrial partners dedicated to the Hall-Héroult electrolytic aluminum production or other molten-salt technologies (the purification process and electroslag refining).

Sinkhole hazard assessment in Lesina Marina area (Apulia, Italy)

NASA Astrophysics Data System (ADS)

Canora, F.; Caporale, F.; D'Angella, A.; Fidelibus, D.; Gutierrez, F.; Pellicani, R.; Spilotro, G.

2012-04-01

In "Lesina Marina" area, located in the north-western part of the Apulia region (Italy), near the Adriatic coast, sinkhole phenomena are particularly widespread and constitute a risk for the built-up area. These phenomena are due to the structure of the evaporitic rocks located in the study area and to the groundwater regime, influenced by the presence of a channel that connects the sea to the lagoon. The complex sea-channel-lagoon system produces an inland flow towards the channel modulated by the tide with a variable width according to the rules of the coastal aquifers. Further studies have been carried out in order to clarify the context and the causes of this instability phenomenon. A procedure for the sinkhole susceptibility and hazard assessment has been performed, in order to evaluate the spatial distribution of the most unstable areas and the potential spatio-temporal evolution of the phenomenon. The sinkhole susceptibility model has been created in GIS by assessing the spatial relationship between the sinkhole inventory map and a series of thematic maps relative to instability factors. The thematic layers selected for the study are nine and cover geometrical features of the surface, of the gypsum rockhead and of the incoherent soil cover, groundwater and daily and seasonal groundwater level variations. Daily groundwater variation in a semiconfined coastal aquifer can be related to the permeability and to the void structures of the evaporitic mass. In the years subsequent to 1980, when the first reports of the presence of sinkholes are dated, the evolution of these instabilities in terms of their number and of their increase of extension has been monitored with repeated surveys. These data were used for susceptibility model validation and to define the hazard model. The selected layers revealed to be very useful in describing and mapping the hazard coming from suffusion sinkholes in the study area. The sinkhole hazard assessment is carried out, according to

Cone-penetrometer exploration of sinkholes: Stratigraphy and soil properties

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloomberg, D.; Upchurch, S.B.; Hayden, M.L.

1988-10-01

Four sinkholes with varying surficial expressions were subjected to detailed stratigraphic and soil analysis by means of Standard Penetration Tests (SPT) and Electric Friction Cone Penetration Tests (CPT) in order to evaluate applications of CPT to sinkhole investigations. Although widely used, SPT data are of limited value and difficult to apply to sinkhole mapping. CPT is sensitive to minor lithologic variability and is superior to SPT as a cost-effective technique for determining geotechnical properties of sinkholes. The effectiveness of CPT data results from the force measurements made along the sleeve of the cone. The friction ratio (ratio of sleeve tomore » tip resistance) is a good indicator of soil stratigraphy and properties. By smoothing the friction-ratio data, general stratigraphy and changes in soil properties are easily identified. Stratigraphy of the sinks has been complicated by intense weathering, karstification and marine transgressions. The resulting deposits include five stratigraphic units. 1 and 2 represent Plio-Pleistocene marine sediments with Unit 2 being the zone of soil clay accumulation. 3 and 4 are horizons residual from Miocene strata and indicate an episode of karstification prior to deposition of Units 1 and 2. CPT provides sufficient information for recognition of sinkhole stratigraphy and geotechnical properties. When coupled with laboratory soil analysis, CPT provides unique information about sinkhole geometry and dynamics. In contrast, SPT indicates general, inconclusive trends.« less

Using InSAR to Observe Sinkhole Activity in Central Florida

NASA Astrophysics Data System (ADS)

Oliver-Cabrera, T.; Wdowinski, S.; Kruse, S.; Kiflu, H. G.

2017-12-01

Sinkhole collapse in Florida is a major geologic hazard, threatening human life and causing substantial damage to property. Detecting sinkhole deformation before a collapse is an important but difficult task; most techniques used to monitor sinkholes are spatially constrained to relatively small areas (tens to hundred meters). To overcome this limitation, we use Interferometric Synthetic Aperture Radar (InSAR), which is a very useful technique for detecting localized deformation while covering vast areas. InSAR results show localized deformation at several houses and commercial buildings in different locations along the study sites. We use a subsurface imaging technique, ground penetrating radar, to verify sinkhole existence beneath the observed deforming areas.

A remote sensing evaluation of potential for sinkhole occurrence

NASA Technical Reports Server (NTRS)

Casper, J.; Ruth, B.; Degner, J. (Principal Investigator)

1981-01-01

The relationship between lowering of the water table and sinkhole development in Pierson and in Hillsborough County, Florida was investigated. The locations of recently developed (1973) collapses were examined with respect to lineaments or fracture traces that are expressed in the terrain and visible in aerial photography and satellite imagery. It was anticipated that these relationships would provide the basis for establishment of criteria for mapping those land areas that have the greatest potential for sinkhole development. A very good correlation was found between mapped lineament intersections and known location of sinkhole occurrences for both study areas. This indicates that lineament and fracture trace mapping may be very useful in locating zones with the greatest potential for sinkhole development. It is further shown that this information is quite beneficial in land use planning applications.

Into the Abyss: The Case of the Collapsing Sinkhole.

ERIC Educational Resources Information Center

Ozsvath, David L.

2000-01-01

Presents a case study to teach about the relationship between sinkhole development and groundwater levels in Orlando, Florida. Discusses the relationship between groundwater levels and sinkhole formation in a karst terrane. Includes discussion questions. (YDS)

Early sinkhole detection using a drone-based thermal camera and image processing

NASA Astrophysics Data System (ADS)

Lee, Eun Ju; Shin, Sang Young; Ko, Byoung Chul; Chang, Chunho

2016-09-01

Accurate advance detection of the sinkholes that are occurring more frequently now is an important way of preventing human fatalities and property damage. Unlike naturally occurring sinkholes, human-induced ones in urban areas are typically due to groundwater disturbances and leaks of water and sewage caused by large-scale construction. Although many sinkhole detection methods have been developed, it is still difficult to predict sinkholes that occur in depth areas. In addition, conventional methods are inappropriate for scanning a large area because of their high cost. Therefore, this paper uses a drone combined with a thermal far-infrared (FIR) camera to detect potential sinkholes over a large area based on computer vision and pattern classification techniques. To make a standard dataset, we dug eight holes of depths 0.5-2 m in increments of 0.5 m and with a maximum width of 1 m. We filmed these using the drone-based FIR camera at a height of 50 m. We first detect candidate regions by analysing cold spots in the thermal images based on the fact that a sinkhole typically has a lower thermal energy than its background. Then, these regions are classified into sinkhole and non-sinkhole classes using a pattern classifier. In this study, we ensemble the classification results based on a light convolutional neural network (CNN) and those based on a Boosted Random Forest (BRF) with handcrafted features. We apply the proposed ensemble method successfully to sinkhole data for various sizes and depths in different environments, and prove that the CNN ensemble and the BRF one with handcrafted features are better at detecting sinkholes than other classifiers or standalone CNN.

Applying a weighted random forests method to extract karst sinkholes from LiDAR data

NASA Astrophysics Data System (ADS)

Zhu, Junfeng; Pierskalla, William P.

2016-02-01

Detailed mapping of sinkholes provides critical information for mitigating sinkhole hazards and understanding groundwater and surface water interactions in karst terrains. LiDAR (Light Detection and Ranging) measures the earth's surface in high-resolution and high-density and has shown great potentials to drastically improve locating and delineating sinkholes. However, processing LiDAR data to extract sinkholes requires separating sinkholes from other depressions, which can be laborious because of the sheer number of the depressions commonly generated from LiDAR data. In this study, we applied the random forests, a machine learning method, to automatically separate sinkholes from other depressions in a karst region in central Kentucky. The sinkhole-extraction random forest was grown on a training dataset built from an area where LiDAR-derived depressions were manually classified through a visual inspection and field verification process. Based on the geometry of depressions, as well as natural and human factors related to sinkholes, 11 parameters were selected as predictive variables to form the dataset. Because the training dataset was imbalanced with the majority of depressions being non-sinkholes, a weighted random forests method was used to improve the accuracy of predicting sinkholes. The weighted random forest achieved an average accuracy of 89.95% for the training dataset, demonstrating that the random forest can be an effective sinkhole classifier. Testing of the random forest in another area, however, resulted in moderate success with an average accuracy rate of 73.96%. This study suggests that an automatic sinkhole extraction procedure like the random forest classifier can significantly reduce time and labor costs and makes its more tractable to map sinkholes using LiDAR data for large areas. However, the random forests method cannot totally replace manual procedures, such as visual inspection and field verification.

Space-Based Detection of Sinkhole Activity in Central Florida

NASA Astrophysics Data System (ADS)

Oliver-Cabrera, T.; Kruse, S.; Wdowinski, S.

2015-12-01

Central Florida's thick carbonate deposits and hydrological conditions have made the area prone to sinkhole development. Sinkhole collapse is a major geologic hazard in central Florida threatening human life and causing substantial damage to property. According to the Florida Senate report in 2010, between 2006-2010 total insurance claims due to sinkhole activity were around $200 million per year. Detecting sinkhole deformation before a collapse is a very difficult task, due to small or sometimes unnoticeable surface changes. Most techniques used to monitor sinkholes provide very localized information and cannot be implemented to study broad areas. This is the case of central Florida, where the active zone spans over hundreds of square-kilometers. In this study we use Interferometric Synthetic Aperture Radar (InSAR) observations acquired over several locations in central Florida to detect possible pre-collapse deformation. The study areas were selected because they have shown suspicious sinkhole behavior. One of the sites collapsed on March 2013 destroying a property and killing a man. To generate the InSAR results we use six datasets acquired by the TerraSAR-X and Cosmo-SkyMed satellites with various acquisition modes reflecting pixel resolutions between 25cm and 2m. Preliminary InSAR results show good coherence over constructed areas and low coherence in vegetated zones, justifying our analysis that focuses on the man-made structures. After full datasets will be acquired, a Persistent Scatterer Interferometry (PSI) time series analysis will be performed for detecting localized deformation at spatial scale of 1-5 meters. The project results will be verified using Ground Penetrating Radar.

Plant distribution-altitude and landform relationships in karstic sinkholes of Mediterranean region of Turkey.

PubMed

Ozkan, Kürsad; Gulsoy, Serkan; Mert, Ahmet; Ozturk, Munir; Muys, Bart

2010-01-01

The purpose of this study was to investigate the relationships between the plant distribution and the altitude-shape-size characteristics of sinkholes, and the landform characteristics inside sinkholes in the Mediterranean region of Turkey. Block kriging, Factor analysis, Cluster Analysis and Detrended Correspondence Analysis were performed. The sinkhole type and altitudinal zone were found to be the significant factors affecting the plant distribution. However, the sinkhole type was more important than the altitudinal zone. Hence, the sinkholes were first subdivided into groups according to types and then the groups were divided into subgroups according to the altitudinal zones. Consequently, 4 groups were defined; A-type sinkholes [1400-1550 m (A1), 1550-1700 m (A2)] and B-type sinkholes [1400-1550 (B1), 1550-1700 m (B2)]. The B-type was wider vertically and shorter horizontally than A-type sinkholes. Significant differences were found between the plant distribution and slope position inside the sinkholes. Plant distribution in the lower slopes was different from that in the flats and ridges in the B1 sub-type of B-type. Plant distribution in B2 subtype was different among the slope positions (ridge, middle slope, lower slope, and flat). Although distribution of plants is different in different parts (ridges, upper slope, middle slope, lower slope and basal flats) of A sinkhole, the differences between the parts of intermediate slope position are not significant. A high plant variability along short distances in the sinkholes was observed in the study area. That is why the site of sinkholes have a big potential for the distribution of many species. Hence, the area must be separated as strictly protected zone.

Geophysical Investigations of a Sinkhole in the Amargosa Desert, Nevada

NASA Astrophysics Data System (ADS)

Sandberg, S. K.; Rogers, N. T.; Stamatakos, J. A.; LaFemina, P. C.; Connor, C. B.

2001-12-01

An unusual sinkhole (10 m opening, 20 m length, and 10 m depth) is exposed within the Quaternary alluvial fill in the Amargosa desert in southern Nevada, approximately 500 north-northeast of the Horse Tooth discharge deposit. We employed a variety of geophysical methods to investigate the structural setting of the sinkhole in order to evaluate formative hypotheses, including the possible role of groundwater discharge. Geophysical methods included total-field magnetics, very low frequency electromagnetics (VLF), terrain conductivity (horizontal loop electromagnetics), spontaneous polarization (SP), transient electromagnetics (TEM), mise-a-la-masse resistivity, and magnetometric resistivity (MMR). Total-field magnetic data were collected at two scales. A regional coverage of an area approximately 1.4 km by 1.4 km surrounding the sinkhole consisted of lines spaced 100 m apart. Data along the lines were gathered at 3-5 m intervals. Measurement locations were controlled by real-time differential GPS readings. A local magnetic survey of the area immediately adjacent to the sinkhole consisted of profiles 20 m apart, with a discrete station spacing of 2 m. Magnetic anomalies up to 1500 nT are identifiable based on strong normal- and reversed-polarity remanent magnetizations in the underlying bedrock tuff. Formation of the sinkhole appears to be related to complex interaction of N-S and NW-SE faults. Magnetic anomalies depict complexly faulted tuff dominated by north-south striking extensional faults. Similar fault patterns occur near the Horse Tooth discharge deposit. Near the sinkhole, a NW-trending magnetic anomaly appears to be associated with the surficial expression of the sinkhole. Terrain conductivity data show near-surface structure and lithologic changes at the sinkhole. VLF data, when converted to current density, show similar trends. However, VLF current density modeled from deeper in the section indicates a NW-SE range-front fault to the west of the sinkhole

Sinkhole development resulting from ground-water withdrawal in the Tampa area, Florida

USGS Publications Warehouse

Sinclair, William C.

1982-01-01

The area of municipal well fields on the Gulf Coastal Plain north of tampa, Fla., is densely pitted with natural sinkholes and sinkhole lakes that have resulted from collapse of surficial sand and clay into solution cavities in the underlying carbonate rocks of the Floridan aquifer. Although solution of the underlying rocks is the ultimate cause of sinkholes, some have been induced by abrupt changes in ground-water levels caused by pumping. Declines in water levels cause loss of support to the bedrock roofs over cavities and to surficial material overlying openings in the top of bedrock. The volume of calcium, magnesium , and carbonate (the constituents of limestone and dolomite) in solution in the water withdrawn from four well fields near Tampa totaled about 240,000 cubic feet in 1978. Most induced solution takes place at the limestone surface however, and the area of induced recharge is so extensive that the effect of induced limestone solution on sinkhole development is negligible. Alinement of established sinkholes along joint patterns in the bedrock suggests that a well along these lineations might have direct hydraulic connection with a zone of incipient sinkholes. Therefore, pumping of large-capacity wells along such lineations would increase the probability of sinkhole development. Although sinkholes generally form abruptly in the study area, local changes such as vegetative stress, ponding of rainfall, misalinement of structures, and turbidity in well water are all indications that percollapse subsidence may be taking place. (USGS)

Sinkhole monitoring and early warning: An experimental and successful GB-InSAR application

NASA Astrophysics Data System (ADS)

Intrieri, Emanuele; Gigli, Giovanni; Nocentini, Massimiliano; Lombardi, Luca; Mugnai, Francesco; Fidolini, Francesco; Casagli, Nicola

2015-07-01

Sinkholes represent a natural risk that may hit catastrophically without clearly detectible precursors. However, they are often overlooked by people and administrators. Therefore sinkhole monitoring and associated early warnings constitute important research topics but, currently, only a few papers about sinkhole prediction can be found. In this paper an experience of sinkhole monitoring and early warning with GB-InSAR is described. The latter is a highly precise instrument that is able to produce displacement maps with metric spatial resolution. The described activities were carried out on Elba Island (central Italy), where karstified limestone set off the occurrence of nine sinkholes since 2008, all within less than 3000 m2, causing major damage to an important road and many indirect losses. In 1 year of monitoring two deforming areas were detected, and the point where a sinkhole was about to propagate to the street level was predicted, thus permitting the preventive closure of the road. The deformation area was larger than the hole generated by the sinkhole, thus showing a subsidence that continued for a prolonged time even after the cavity was filled up. The occurrence of a 1.5-m-wide sinkhole, undetected by the GB-InSAR, also showed the lower detection limit of the instrument.

Mapping subsurface in proximity to newly-developed sinkhole along roadway.

DOT National Transportation Integrated Search

2013-02-01

MS&T acquired electrical resistivity tomography profiles in immediate proximity to a newly-developed sinkhole in Nixa Missouri : The sinkhole has closed a well-traveled municipal roadway and threatens proximal infrastructure. The intent of this inves...

Monitoring of sinkholes and subsidence affecting the Jordanian coast of the Dead Sea through Synthetic Aperture Radar data and last generation Sentinel-1 data

NASA Astrophysics Data System (ADS)

Tessari, Giulia; Riccardi, Paolo; Lecci, Daniele; Pasquali, Paolo; Floris, Mario

2017-04-01

Since the mid-1980s the coast of the Dead Sea is affected by sinkholes occurring over and around the emerged mud and salt flats. Strong subsidence and landslides also affect some segments of the coast. Nowadays, several thousands of sinkholes attest that the degradation of the Dead Sea coast is worsening. Furthermore, soil deformations are interesting the main streets running along both the Israeli and Jordanian sides of the Dead Sea. These hazards are due to the dramatic dropping of the Dead Sea level, characterized by an increasing rate from about 60 cm/yr in the 1970s up to 1 m/yr in the 2000s, which provokes a lowering of the fresh-saline groundwater interface, replacing the hypersaline groundwater with fresh water and causing a consequent erosion of the subsurface salt layers. Subsidence, sinkholes, river erosion and landslides damage bridges, roads, dikes, houses, factories worsening this ongoing disaster. One of the most emblematic effects is the catastrophic collapse of a 12-km newly constructed dyke, located on the Lisan Peninsula (Jordan), occurred in 2000. Differential Interferometric Synthetic Aperture Radar (DInSAR) techniques and Advanced stacking DInSAR techniques (A-DInSAR) were applied to investigate sinkholes and subsidence affecting the Jordanian coast of the Dead Sea. The use of SAR data already proof to be efficient on the risk management of the area, allowing to identify a vulnerable portion of an Israeli highway, averting a possible collapse. Deformation analysis has been focused on the Ghor Al Haditha area and Lisan peninsula, located in the South-Eastern part of the lake coast. The availability of a huge database of SAR data, since the beginning of the 90s, allowed to observe the evolution of the displacements which are damaging this area. Furthermore, last generation Sentinel-1 data, acquired by the ESA mission, were processed to obtain information about the recent evolution of the subsidence and sinkholes affecting the study area, from

Evaluation of sinkhole occurrence in the Valley and Ridge Province, East Tennessee: Phase 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newton, J.G.; Tanner, J.M.

1987-11-01

Data from a reconnaissance-type inventory of sinkhole occurrence and from more detailed inventories in selected areas were used to determine regional density and frequency of sinkhole occurrence in the Valley and Ridge Province, Tennessee. The overall database consisted of 333 sinkholes of which 211, or 63 percent of the total, were classified as induced. Almost all induced sinkholes resulted from construction activities, such as grading, ditching, and impoundment of water. Extrapolation of data to provide estimates of regional sinkhole density necessitated adjustment of the reconnaissance inventory. Adjustment factors were calculated by comparing reconnaissance inventories from selected areas with those obtainedmore » from detailed inventories in the same areas. The number of sinkholes in the detailed inventories was 5 and 8.5 times greater than the number in the reconnaissance inventories.« less

A generalized genetic framework for the development of sinkholes and Karst in Florida, U.S.A.

NASA Astrophysics Data System (ADS)

Beck, Barry F.

1986-03-01

Karst topography in Florida is developed on the Tertiary limestones of the Floridan aquifer Post-depositional diagenesis and solution have made these limestones highly permeable, T=ca. 50,000 m2/d. Zones of megaporosity have formed at unconformities, and dissolution has enlarged joints and fractures Erosion of the overlying clastic Miocene Hawthorn group strata on one flank of a structural arch has exposed the limestone The elevated edge of the Hawthorn cover forms the Cody scarp Ubiquitous solution pipes have previously formed at joint intersections and are now filled Downwashing of the fill deeper into solution cavities in the limestone and subsidence of the overlying unconsolidated sediments causes surface collapse a subsidence doline or sinkhole This process may penetrate up to 60 m of the semi-consolidated Hawthorn cover, as occurred when the Winter Park sinkhole developed Dense clusters of solution pipes may have formed cenotes which are now found on the exposed limestone terrain Groundwater moves laterally as diffuse flow except where input or outflow is concentrated. At sinking streams, vertical shafts, and springs, karst caves have formed, but only the major sinking streams form through-flowing conduit systems Shaft recharge dissipates diffusely. Spring discharge is concentrated from diffuse flow In both cases, conduits taper and merge into a zone of megaporosity

Human-induced hydrological changes and sinkholes in the gypsum karst of Lesina Marina area (Foggia Province, Italy)

NASA Astrophysics Data System (ADS)

Fidelibus, M. D.; Gutierrez, F.; Spilotro, G.

2009-04-01

The Lesina Lagoon is located in the East-West-trending northern cost of Gargano (southern Italy). The lagoon is fed by springs draining the northern side of the Gargano Mesozoic carbonate aquifer and is connected with the sea by three channels, including the 2.2 km long Acquarotta Canal with a N-S orientation. The sea-side mouth of this canal was frequently clogged by sand accumulation. In 1927, the path of the northern section of this canal was changed to improve the water exchange between the lagoon and the Adriatic Sea for environmental and fish-farming purposes. The new portion of the canal, 8.5 m wide and 1.5 m deep, was excavated in evaporite bedrock and in a small outcrop of igneous rocks situated in the coast that inhibits sand accumulation. The Acquarotta Canal conveys water in both directions depending on the relative water levels of the lagoon and the sea. Initially the reach of the canal dug in gypsum was lined with concrete, which was replaced in 1993 by gabions for scenery improvement. The northern reach of the canal is dug in Upper Triassic gypsiferous sediments of the Burano Anhydrite Formation. The evaporite bedrock is mantled by unconsolidated deposits a few meters thick, largely made up of loose sand. The exposures found in the banks of the canal and in some sinkholes reveal that the gypsum has a high density of dissolutional conduits and cavities. Locally, it also shows open fractures and brecciated structure (crackle, mosaic and chaotic packbreccias) caused by dissolution-induced collapse processes. These voids, either of solutional or mechanical origin, are partially filled with detrital sediments derived from the mantling deposits. These features seem to correspond to a paleokarst, probably developed at several depths controlled by different and much lower sea level stands during the Quaternary. The construction Acquarotta Canal has caused significant changes in the local hydrology. According to the piezometric series recorded at several

Evaluating and comparing methods of sinkhole susceptibility mapping in the Ebro Valley evaporite karst (NE Spain)

NASA Astrophysics Data System (ADS)

Galve, J. P.; Gutiérrez, F.; Remondo, J.; Bonachea, J.; Lucha, P.; Cendrero, A.

2009-10-01

Multiple sinkhole susceptibility models have been generated in three study areas of the Ebro Valley evaporite karst (NE Spain) applying different methods (nearest neighbour distance, sinkhole density, heuristic scoring system and probabilistic analysis) for each sinkhole type separately (cover collapse sinkholes, cover and bedrock collapse sinkholes and cover and bedrock sagging sinkholes). The quantitative and independent evaluation of the predictive capability of the models reveals that: (1) The most reliable susceptibility models are those derived from the nearest neighbour distance and sinkhole density. These models can be generated in a simple and rapid way from detailed geomorphological maps. (2) The reliability of the nearest neighbour distance and density models is conditioned by the degree of clustering of the sinkholes. Consequently, the karst areas in which sinkholes show a higher clustering are a priori more favourable for predicting new occurrences. (3) The predictive capability of the best models obtained in this research is significantly higher (12.5-82.5%) than that of the heuristic sinkhole susceptibility model incorporated into the General Urban Plan for the municipality of Zaragoza. Although the probabilistic approach provides lower quality results than the methods based on sinkhole proximity and density, it helps to identify the most significant factors and select the most effective mitigation strategies and may be applied to model susceptibility in different future scenarios.

Relations between sinkhole density and anthropogenic contaminants in selected carbonate aquifers in the eastern United States

USGS Publications Warehouse

Lindsey, Bruce D.; Katz, Brian G.; Berndt, Marian P.; Ardis, Ann F.; Skach, Kenneth A.

2009-01-01

The relation between sinkhole density and water quality was investigated in seven selected carbonate aquifers in the eastern United States. Sinkhole density for these aquifers was grouped into high (>25 sinkholes/100 km2), medium (1–25 sinkholes/100 km2), or low (2) categories using a geographical information system that included four independent databases covering parts of Alabama, Florida, Missouri, Pennsylvania, and Tennessee. Field measurements and concentrations of major ions, nitrate, and selected pesticides in samples from 451 wells and 70 springs were included in the water-quality database. Data were collected as a part of the US Geological Survey (USGS) National Water-Quality Assessment (NAWQA) Program. Areas with high and medium sinkhole density had the greatest well depths and depths to water, the lowest concentrations of total dissolved solids and bicarbonate, the highest concentrations of dissolved oxygen, and the lowest partial pressure of CO2 compared to areas with low sinkhole density. These chemical indicators are consistent conceptually with a conduit-flow-dominated system in areas with a high density of sinkholes and a diffuse-flow-dominated system in areas with a low density of sinkholes. Higher cave density and spring discharge in Pennsylvania also support the concept that the high sinkhole density areas are dominated by conduit-flow systems. Concentrations of nitrate-N were significantly higher (p < 0.05) in areas with high and medium sinkhole density than in low sinkhole-density areas; when accounting for the variations in land use near the sampling sites, the high sinkhole-density area still had higher concentrations of nitrate-N than the low sinkhole-density area. Detection frequencies of atrazine, simazine, metolachlor, prometon, and the atrazine degradate deethylatrazine indicated a pattern similar to nitrate; highest pesticide detections were associated with high sinkhole-density areas. These patterns generally persisted when analyzing

Time-lapse gravity and levelling in the sinkhole-endangered urban area of Bad Frankenhausen, Germany

NASA Astrophysics Data System (ADS)

Kobe, Martin; Gabriel, Gerald; Weise, Adelheid; Krawczyk, Charlotte; Vogel, Detlef

2017-04-01

Sinkholes, resulting from subrosion in the subsurface, can reach diameters of several hundred meters and thus pose a severe hazard for infrastructure and inhabitants in urban areas. Subrosion is the leaching of readily-soluble rocks, such as rock salt, gypsum, anhydrite and limestone by ground or meteoric water and leads to mass transport and relocation. Two scenarios of sinkhole evolution are conceivable: First, the surface subsides continuously in order to compensate for the mass loss. Second, the mass relocation leads to development of subsurface cavities. If they reach a critical size and the cover layers are not supported anymore, the surface collapses abruptly. To improve the understanding of subrosion processes and the related surface deformation a case study is conducted in Bad Frankenhausen, Germany, where subrosion leaches the Zechstein evaporates of the Permian. One part of the study is to analyse the spatiotemporal development of sinkholes by applying time-lapse observations. Therefore, we established a monitoring network consisting of 15 gravity and additional levelling points covering the main sinkhole areas in the city centre. In March 2014, the baseline survey was carried out. Since then, quarterly measurement campaigns are performed. In each campaign four different gravity meters are used to collect a statistical significant amount of data and to control the plausibility of our data. The gravity measurements are complemented by levelling surveys. The rectification of the time-lapse gravity data comprises the correction for jumps and systematic errors, as well as for well calculable influences, such as earth tides and air pressure changes. Furthermore, special interest was applied to seasonal changes of hydrological parameters such as soil moisture or groundwater level. We found the hydrological influence to be in the single digit up to the lower two-digit µGal range, depending on the season and the station. The standard deviations of the adjusted

Sediment Dynamics Within Buffer Zone and Sinkhole Splay Areas Under Extreme Soil Disturbance Conditions.

PubMed

Schoonover, Jon E; Crim, Jackie F; Williard, Karl W J; Groninger, John W; Zaczek, James J; Pattumma, Klairoong

2015-09-01

Sedimentation dynamics were assessed in sinkholes within training areas at Ft. Knox Military Installation, a karst landscape subjected to decades of tracked vehicle use and extreme soil disturbance. Sinkholes sampled were sediment-laden and behaved as intermittent ponds. Dendrogeomorphic analyses were conducted using willow trees (Salix spp.) located around the edge of 18 sinkholes to estimate historical sedimentation rates, and buried bottles were installed in 20 sinkholes at the center, outer edge, and at the midpoint between the center and edge to estimate annual sedimentation rates. Sedimentation data were coupled with vegetation characteristics of sinkhole buffers to determine relationships among these variables. The dendrogeomorphic method estimated an average accumulation rate of 1.27 cm year(-1) translating to a sediment loss rate of 46.1 metric ton year(-1) from the training areas. However, sediment export to sinkholes was estimated to be much greater (118.6 metric ton year(-1)) via the bottle method. These data suggest that the latter method provided a more accurate estimate since accumulation was greater in the center of sinkholes compared to the periphery where dendrogeomorphic data were collected. Vegetation data were not tightly correlated with sedimentation rates, suggesting that further research is needed to identify a viable proxy for direct measures of sediment accumulation in this extreme deposition environment. Mitigation activities for the sinkholes at Ft. Knox's tank training area, and other heavily disturbed karst environments where extreme sedimentation exists, should consider focusing on flow path and splay area management.

Spatial analysis of geologic and hydrologic features relating to sinkhole occurrence in Jefferson County, West Virginia

USGS Publications Warehouse

Doctor, Daniel H.; Doctor, Katarina Z.

2012-01-01

In this study the influence of geologic features related to sinkhole susceptibility was analyzed and the results were mapped for the region of Jefferson County, West Virginia. A model of sinkhole density was constructed using Geographically Weighted Regression (GWR) that estimated the relations among discrete geologic or hydrologic features and sinkhole density at each sinkhole location. Nine conditioning factors on sinkhole occurrence were considered as independent variables: distance to faults, fold axes, fracture traces oriented along bedrock strike, fracture traces oriented across bedrock strike, ponds, streams, springs, quarries, and interpolated depth to groundwater. GWR model parameter estimates for each variable were evaluated for significance, and the results were mapped. The results provide visual insight into the influence of these variables on localized sinkhole density, and can be used to provide an objective means of weighting conditioning factors in models of sinkhole susceptibility or hazard risk.

Acoustic activation of water-in-oil microemulsions for controlled salt dissolution.

PubMed

Baxamusa, Salmaan; Ehrmann, Paul; Ong, Jemi

2018-06-18

The dynamic nature of the oil-water interface allows for sequestration of material within the dispersed domains of a microemulsion. Microstructural changes should therefore change the dissolution rate of a solid surface in a microemulsion. We hypothesize that microstructural changes due to formulation and cavitation in an acoustic field will enable control over solid dissolution rates. Water-in-oil microemulsions were formulated using cyclohexane, water, Triton X-100, and hexanol. The microstructure and solvation properties of Winsor Type IV formulations were characterized. Dissolution rates of KH 2 PO 4 (KDP), were measured. A kinetic analysis isolated the effect of the microstructure, and rate enhancements due to cavitation effects on the microstructure were characterized by measuring dissolution rates in an ultrasonic field. Dispersed aqueous domains of 2-6 nm radius dissolve a solid block of KDP at 0-10 nm/min. Dissolution rate is governed not by the domain-surface collision frequency but rather by a dissolution probability per domain-surface encounter. Higher probabilities are correlated with larger domains. Rapid and reversible dissolution rate increases of up to 270× were observed under ultrasonic conditions, with <20% of the increase due to bulk heating effects. The rest is attributed to cavitation-induced changes to the domain microstructure, providing a simple method for remotely activating and de-activating dissolution. Copyright © 2018 Elsevier Inc. All rights reserved.

Monitoring and modeling of sinkholes affecting the Jordanian coast of the Dead Sea through satellite interferometric techniques

NASA Astrophysics Data System (ADS)

Tessari, Giulia; Pasquali, Paolo; Floris, Mario

2016-04-01

Differential Interferometric Synthetic Aperture Radar (DInSAR) techniques have been applied to investigate sinkholes affecting the Jordanian coast of the Dead Sea. The Dead Sea is a hyper saline terminal lake located in a pull-apart basin. Most of the area is characterized by highly karstic and fractured rock formations that are connected with faults. Karstic conduits extend from the land into the sea. Since the 1960s, the Dead Sea level is dropping at an increasing rate: from about 60 cm/yr in the 1970s up to 1 m/yr in the 2000s. From about the mid-1980s, sinkholes appeared more and more frequently over and around the emerged mudflats and salt flats. Strong subsidence and landslides also affect some segments of the coast. Nowadays, several thousands of sinkholes attest that the degradation of the Dead Sea coast is worsening. Deformation analysis has been focused on the Ghor Al Haditha area, located in the South-Eastern part of the lake coast. SAR data acquired by three different sensors, ERS, ENVISAT and COSMO- SkyMed have been analysed. 70 ERS images from 1992 to 2009 and 30 ENVISAT images from 2003 to 2010 have been processed. SBAS technique has been applied to define surface velocity and displacement maps. Results obtained from the SBAS technique, applied to ERS and Envisat data, highlight a diffuse subsiding of the entire Eastern coast of the Dead Sea. It was not possible to detect single sinkholes because of the resolution of these sensors (25m2) and the small size of each punctual event that is generally varying from a few meters to a hundred meters diameter. Furthermore, SBAS has been applied to 23 COSMO-SkyMed SAR satellite images from December 2011 to May 2013. The high resolution of these data (3m x 3m) and the short revisiting time allowed precise information of the displacement of punctual sinkholes beyond the overall subsidence of the coast. A specific sinkhole has been identified in order to understand its temporal evolution. The considered

Photogeologic map showing distribution of sinkholes south of Fairplay, Park County, Colorado--a possible geologic hazard

USGS Publications Warehouse

Shawe, D.R.; Steven, T.A.; Taylor, R.B.; Maxwell, C.H.

1995-01-01

A large group of at least 50, and perhaps significantly more, sinkholes partially surrounds Black Mountain 6-10 mi south Fairplay in South Park, Park County, Colorado. The sinkholes occur in bedrock in the evaporite facies of the Middle Pennsylvania Minturn Formation, and in Quaternary soil, alluvium, and glacial outwash gravels that overlie the evaporite beds. Sinkholes range in size from small depressions a few feet across to large holes several hundred feet across. Measured sinkholes range in size from about 25 ft in diameter and 2 ft deep to about 235 ft in diameter and 25 ft deep. In places, several sinkholes have coalesced to form depressions as much as 750 ft long and 400 ft wide. One large cluster of small craters is about 1,8000 ft long and 600 ft wide. As reported to us by a resident rancher, one small sinkhole collapsed about 10 years ago. The area of sinkholes extends into land now under development for residences, and the sinkholes thus pose a potential hazard that needs to be considered in future development. Also, they might jeopardize existing farmland, structures, ans roads (including U.S. Highway 285), as well as projected roads and airstrips. This report is not a comprehensive evaluation of the distribution and origin of the sinkholes; its intent is to call attention to their presence and to encourage further study. Many by not all of the sinkholes were visited; the geologic map is based mainly on the interpretation of aerial photographs by D.R. Shawe.

Urbanisation of Suweimeh area, Jordan, versus sinkholes and landslides proliferation

NASA Astrophysics Data System (ADS)

Closson, Damien; Abou Karaki, Najib

2013-04-01

The Dead Sea is a terminal lake whose level lowers each year of about one meter per year since more than one decade. This is caused mainly by the diversion of surface waters from its watershed. Currently, 1/10 of the Jordan River still reaches the salt lake. The rapid lowering of the lake level does not allow all the surrounding groundwater tables to adjust their level to that of the Dead Sea. This imbalance causes an always faster migration of a part of the groundwater causing underground erosion leading to the formation of sinkholes along the coast, especially where discontinuities, such as faults, are present. The first collapses occurred in the years 1980-90. From the 2000s, in Jordan, they have proliferated to the point of causing serious damages to the facilities of the Arab Potash Company, the agricultural area of Ghor Al Haditha, and more recently the touristic region of Suweimeh. Aware of the problem and the need for gradual rising of the lake level, the Jordanian authorities attended from 2009 to 2011 to the feasibility study of the Red Sea - Dead Sea conduit. Currently, on the one hand, the growing environmental imbalance, and, on the other hand, the desires to develop economic activities along the coast, imply that more goods will be exposed to damages. For example, the area of Wadi Mujib Bridge was rebuilt completely in the late 2000s. It is the same for the 12 km of the dam 18 of an evaporation pond Arab Potash Company. The Numeira Salt Factory was completely destroyed in Ghor Al Haditha and was relocated to Safi. In August 2012, during touristic period, a landslide destroyed half of the Holiday Inn front beach, Suweimeh area ... End of December 2012, a team lead by Prof. Najib Abou Karaki warned the Arab Potash Company of the presence of a circular depression 250 m in diameter within the evaporation pond SP-0A. Although the dike of this saltpan is closely monitored, the exact location and shape of this large sinkhole were not known to the security

The Hydrochemical Evolution of Water-Filled Sinkholes at Bitter Lake NWR, Roswell, NM

NASA Astrophysics Data System (ADS)

Premo, E.; Crossey, L. J.

2013-12-01

Bitter Lake National Wildlife Refuge in Roswell, NM houses one of the most ecologically significant wetlands in the US-SW including approximately 52 water-filled sinkholes each supporting a unique biological assemblage, including several endangered and endemic species (e.g., Pecos pupfish and Noel's amphipod, respectively). Forming in the karst landscape adjacent to the Pecos River where the regional dual-aquifer system discharges through a network of springs and seeps, these sinkholes are recharged by saline groundwater that is subject to anthropogenic withdrawals for irrigation and hydrocarbon production and chemically altered by a complex series of evaporation-precipitation reactions after discharge. This study investigates the hydrochemical differences among these sinkholes while considering the evolutionary processes affecting water column structure, geochemical mixing and ecological sustainability. Two major sampling suites, pre- and post-irrigation, yielded waters from 1.0m increments along the water columns of 10 representative sinkholes. Samples were analyzed for major ions, stable isotopes [δ18O, δD ], and dissolved gases; PHREEQc was used to model mineral saturation and speciation. An in-situ mineral precipitation experiment provided growth rate and mineral morphological (SEM) data. Source water is chemically similar to shallow springs found at the Refuge (Sago Spring). Sinkholes exhibit bimodal water column structure (well-mixed or stratified) organized in response to water density (with ~1.035 g/cm3 forming the modal transition threshold). By measuring the density, TDS or conductivity at sinkhole surface it is possible to predict modality of water column structure. Sinkhole waters - regardless of depth or season - fall along a common isotopic evaporation trajectory (δ D = 3.387*δ18O - 19.38), and adopt a Na-Cl chemical endmember facies. Driven primarily by physical sinkhole geometry (e.g., depth and surface area), sinkhole water follows a

Quantitative assessment of pedodiversity and soil erosion within a karst sinkhole in the dry steppe subzone

NASA Astrophysics Data System (ADS)

Smirnova, M. A.; Gennadiev, A. N.

2017-08-01

A detailed study of the soil cover of a sinkhole (300 m2) in the dry steppe landscape of the Bogdinsk-Baskunchak Natural Reserve in Astrakhan oblast has been performed, and the factors of its differentiation have been analyzed. The indices of pedodiversity have been calculated and compared for karst sinkholes in the dry steppe and northern taiga landscapes. Quantitative parameters of the lateral migration of solid soil substances on the slopes of the sinkhole have been determined. The rate of soil erosion decreases from the slope of southern aspect to the slopes of western, northern, and eastern aspects. On the average, it is estimated at 0.4 mm/yr. The average rate of accumulation of solid substances on the lower parts of the slopes and in the bottom of the sinkhole reaches 0.74 mm/yr. A comparative analysis of the soil properties attests to their dependence on the particular position of a given soil within the sinkhole. Downward the slopes of the sinkhole, full-profile brown arid soils (Cambic Calcisols) are replaced by sierozem-like soils (Haplic Calcisols), light-humus poorly developed soils (Luvisols), lithozems (Leptosols), and stratified soils (stratozems, or Colluvic Regosols). The soils within the upper ring-shape soil microzone are more diverse and contrasting with respect to their morphological, physical, chemical, and physicochemical properties. The degree of soil contrasts decreases down the slopes of the sinkhole towards its bottom. The studied sinkhole is characterized by considerable pedodiversity. Quantitative parameters of pedodiversity for the sinkhole in the dry steppe zone are higher than those form the sinkholes in the northern taiga zone.

Threat of a sinkhole: A reevaluation of Cavern 4, Bayou Choctaw salt dome, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neal, J.T.; Todd, J.L.; Linn, J.K.

1993-09-01

Cavern Lake at Bayou Choctaw salt dome resulted from the failure of Cavern 7 in 1954. Uncontrolled solutioning of this cavern through the thin caprock had set the stage for overburden to collapse into the cavern below. A similar situation developed with nearby Cavern 4, but with less dissolutioning of the caprock. Because pressure loss was already a problem and because another 800 ft diameter lake would have endangered surface operations, solutioning of Cavern 4 was stopped and the cavern abandoned in 1957 in order to protect the already-small site. In 1978 the Strategic Petroleum Reserve (SPR) acquired a numbermore » of caverns at Bayou Choctaw, including Cavern 4, and the possible repeat of the Cavern 7 failure and formation of another lake thus became an issue. The cavern dimensions were re-sonared in 1980 for comparison with 1963 and 1977 surveys. Annual surface leveling between 1982--1992 showed less subsidence occurring than the site average, and a cavern monitoring system, installed in 1984, has revealed no anomalous motion. Repeat sonar surveys in 1992 showed very little, if any, change occurred since 1980 although a small amount of uncertainty exists as a result of changing sonar techniques. We conclude that significant additional solutioning or erosion of the caprock has not occurred and that there is no increased threat to SPR operations.« less

Utilizing NASA Earth Observations to Monitor Sinkhole Development and Identify Risk Areas in Dougherty County, Georgia

NASA Astrophysics Data System (ADS)

Cahalan, M. D.; Berry, K.; Amin, M.; Xu, W.; Hu, T.; Milewski, A.

2015-12-01

Located in southwest Georgia, Dougherty County has a growing populace in an agricultural region that relies heavily on groundwater resources. Partly due to escalated groundwater extraction, this area has experienced an increase in sinkhole development over the last decade. Sinkholes pose a threat to infrastructure development, groundwater pollution, and land use operations. The NASA DEVELOP Georgia Disasters and Water Resources team partnered with the City of Albany and Dougherty County Planning and Development Services (PDS) and the Southwest Georgia Water Resources Task Force (SGWRTF) to assess past sinkhole development and identify areas susceptible to future sinkhole formation. Sinkhole mapping was completed utilizing a time-series of elevation data (1999 - 2011) from NASA's SRTM and ASTER missions, as well as European Remote-Sensing (ERS-1 and 2) satellite-derived elevation data. The sinkhole inventory maps and spatial statistical techniques (i.e., geographically-weighted regression) were employed to quantify the factors most influential in sinkhole development. With those results, the susceptibility of every area within Dougherty County to future sinkhole formation was identified. The results of this applied science project will enable the PDS and SGWRTF to make informed decisions on current and future land use, safe infrastructure development, and sustainable water resource management.

Development of sinkholes resulting from man's activities in the Eastern United States

USGS Publications Warehouse

Newton, John G.

1987-01-01

Alternatives that allow avoiding or minimizing sinkhole hazards are most numerous when a problem or potential problem is recognized during site evaluation. The number of alternatives declines after the beginning of site development. Where sinkhole development is predictable, zoning of land use can minimize hazards.

Direct Push supported geotechnical and hydrogeological characterisation of an active sinkhole area

NASA Astrophysics Data System (ADS)

Tippelt, Thomas; Vienken, Thomas; Kirsch, Reinhard; Dietrich, Peter; Werban, Ulrike

2017-04-01

Sinkholes represent a natural geologic hazard in areas where soluble layers are present in the subsurface. A detailed knowledge of the composition of the subsurface and its hydrogeological and geotechnical properties is essential for the understanding of sinkhole formation and propagation. This serves as base for risk evaluation and the development of an early warning system. However, site models often depend on data from drillings and surface geophysical surveys that in many cases cannot resolve the spatial distribution of relevant hydrogeological and geotechnical parameters sufficiently. Therefore, an active sinkhole area in Münsterdorf, Northern Germany, was investigated in detail using Direct Push technology, a minimally invasive sounding method. The obtained vertical high-resolution profiles of geotechnical and hydrogeological characteristics, in combination with Direct Push based sampling and surface geophysical measurements lead to a strong improvement of the geologic site model. The conceptual site model regarding sinkhole formation and propagation will then be tested based on the gathered data and, if necessary, adapted accordingly.

A seismological study of shallow weak earthquakes in the urban area of Hamburg city, Germany, and its possible relation to salt dissolution

NASA Astrophysics Data System (ADS)

Dahm, Torsten; Heimann, Sebastian; Bialowons, Wilhelm

2010-05-01

In the night from 8/9 April 2009, shortly after midnight on Maundy Thursday before Easter, several people in Gross-Flottbek, Hamburg, felt unusual strong ground shocks so that some of them left their houses in fear of earthquake shaking. Police and Fire Brigade received phone calls of worried residents, and few days later Internet pages were published where people reported their observations. On 21 April 2009 at about 8 p.m. local time a second micro-earthquake was felt. Damage to buildings or infrastructure did not occur to our knowledge. The Institute of Geophysics, University of Hamburg, installed from 22 April to 17 May 2009 three temporal seismic stations in the epicentral area. Seismological data from two close-by stations at the Deutsches Elektron-Synchrotron (DESY) in about 1 km and the Geophysical Institute in about 7 km distance were collected and integrated to the temporal network. The events occurred above the roof of the shallow Othmarschen Langenfelde salt diapir (OLD), in an area known for active sinkhole formation and previous historic ground shaking events. The analysis of the seismological data recovers that three shallow micro-earthquakes occurred from 8 to 21 April at a depth of about 100m, the largest one with a moment magnitude of about MW 0.6. Depth location of such shallow events is difficult with standard methods, and is here constrained by waveform modeling of surface waves. Earthquakes occurring in soft sediments within the uppermost 100 m are a rare phenomena and cannot be explained by standard models. Rupture process in soft sediments differ from those on faults in more competent rock. We discuss the rupture and source mechanism of the earthquakes in the context of previous historic shocks and existing sinkhole and deformation data. Although the event was so weak, the rupture duration was unusual long and possibly 0.3 s. Three possible models for the generation of repeated micro-earthquakes in Gross Flottbek are developed and discussed

Environmental and engineering effects of sinkholes - the processes behind the problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beck, B.F.

1988-10-01

Karstic erosion of the land surface is controlled by processes occurring in the epikarstic zone-the upper portion of the limestone which is most intensely dissolved. Sinkholes developing today are generally the effects of downward movement of mantling sediment into the major karren shafts which drain the epikarstic zone deeper into the true karstic aquifer. Dissolution of the limestone itself does not cause significant changes in man's time frame. The downward erosion of mantling sediment is termed ravelling. Only in uniform sediment will an arched cavity occur. In unconsolidated sediment which is stratified, lateral tunneling may even occur. Only the majormore » karren can transmit sediment downward, the majority are ineffective. In mantled karst the location of surficial depressions and photo-linears does not necessarily correlate to areas of new collapse. The irregular and highly dissolved character of the epikarstic zone complicates foundation engineering. Downward drainage through this zone may be limited and cause flooding. An understanding of processes in the epikarstic zone is essential in developing on karst.« less

Sinkhole management and flooding in Jamaica

NASA Astrophysics Data System (ADS)

Molina, Medardo; McDonald, Franklin

1988-10-01

More than 518 km2 (200 mi2) of prime lands in Jamaica lay on Karstic material where sinkholes are the natural outlet of important streams. Due to increasing social pressure, the lands are inappropriately managed and as a consequence, vegetal debris and silting have plugged the sinkholes which have thus lost their capacity to drain the runoff produced during heavy rainfalls. One of these areas is Cave Valley, which during the last 36 years, has been affected by at least six floodings, some of which have produced losses of life and property, in a sector of the Jamaican population which is already under severe economic hardship. A flood prevention and mitigation project is being implemented including watershed management, river training and community preparedness. A geologic, hydrologic, and hydraulic analysis are also part of this study. All these measures are expected to reduce future losses.

Sinkhole development induced by underground quarrying, and the related hazard

NASA Astrophysics Data System (ADS)

Parise, M.; Delle Rose, M.

2009-04-01

Sinkholes are extremely widespread in Apulia, a very flat and carbonate region, that acted as the foreland during the phases of building up of the Southern Apenninic Chain in Miocene time. This is due to the presence of soluble rocks throughout the region, that highly predispose the area to this very subtle natural hazard. In addition to the natural setting, which favours their development, sinkholes may also be induced by anthropogenic activities. In the latter sense, underground quarrying represents one of the most dangerous activities in karst areas. Apulia has a long history of quarrying. Since the roman time, the local rocks, from the Cretaceous micritic limestones to the Quaternary calcarenites, have been intensely quarried and used as building and ornamental materials. In several settings of the region, the rocks with the best petrographic characteristics are located at depths ranging from a few to some tens of meters. This caused the opening of many underground quarries, and the development of a complex network of subterranean galleries. Underground quarrying had a great impulse at the turn between the XIX and the XX century, when a large number of quarries was opened. Later on, after the Second World War, most of the quarries were progressively abandoned, even because of the first signs of instability, both underground and at the ground surface. With time, the memory of the presence and development of the underground quarries was progressively lost, with severe repercussions on the safety of the land above the excavated areas. Lack of knowledge of the subterranean pattern of galleries, combined with the expansion of the built-up areas at the surface, resulted in increasing significantly the vulnerability of exposed elements at risk. Events such as the 29 March, 2007, at Gallipoli only by chance did not result in any casualties, when a 15-mt wide and 5-mt deep sinkhole opened in a few hours at a road crossing, above the site of an old underground quarry

Statistical thermodynamics unveils the dissolution mechanism of cellobiose.

PubMed

Nicol, Thomas W J; Isobe, Noriyuki; Clark, James H; Shimizu, Seishi

2017-08-30

In the study of the cellulose dissolution mechanism opinion is still divided. Here, the solution interaction components of the most prominent hypotheses for the driving force of cellulose dissolution were evaluated quantitatively. Combining a rigorous statistical thermodynamic theory and cellobiose solubility data in the presence of chloride salts, whose cations progress in the Hofmeister series (KCl, NaCl, LiCl and ZnCl 2 ), we have shown that cellobiose solubilization is driven by the preferential accumulation of salts around the solutes which is stronger than cellobiose hydration. Yet contrary to the classical chaotropy hypothesis, increasing salt concentration leads to cellobiose dehydration in the presence of the strongest solubilizer ZnCl 2 . However, thanks to cellobiose dehydration, cellobiose-salt interaction still remains preferential despite weakening salt accumulation. Based on such insights, the previous hypotheses based on hydrophobicity and polymer charging have also been evaluated quantitatively. Thus, our present study successfully paved a way towards identifying the basic driving forces for cellulose solubilization in a quantitative manner for the first time. When combined with unit additivity methods this quantitative information could lead to a full understanding of cellulose solubility.

The Extreme Results of Climate Changes in Turkey: Sinkholes

NASA Astrophysics Data System (ADS)

Onursal Denli, G.; Denli, H. H.

2016-12-01

During the past few years a strange phenomenon has been increasingly observed all over the world. Residents of various places around the world have been taken aback to find sinkholes suddenly come up in their locality - sometimes involving fatalities. A sinkhole is a depression or hole in the ground caused by some form of collapse of the surface layer. The ground caves in all of a sudden, creating large holes in the ground and sometimes devouring whole buildings. Geologists have offered various theories for the natural causes of sinkholes such as the type of soil / rock giving way to rainwater and underground water. Other natural causes submitted by experts include heavy rainfall, global warming, underground gas explosions, etc. They can also occur from the over-pumping and extraction of groundwater and subsurface fluids. In Turkey, especially mid and south-east Anatolian regions have very arid soils. There is not sufficient rain and irrigation in these regions. Despite of using 75% of the fresh water for agriculture, old methods of irrigation causes wastefulness of water. Planless and randomly used water causes difficulties in agriculture. These regions are known as granary in the country. Because of drought, farmers use underground water with draw well unconsciously. At the result of underground water movement and withdrawal of water to surface, depression and very huge holes are occurred in the ground with tremendous noise. During the last two years dozens of sinkholes occurred in these regions in Turkey. Most of them are in the rural area, the others are also in center of the cities. Various sizes of holes scare the people living in these regions. In this study, sinkholes, which are occurred in different dimensions in central Anatolia region in the last years, are observed and the causes of these formations are examined. According to the reasons, suggestions to avoid these formations will be given respectively.

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates.

PubMed

Litou, Chara; Vertzoni, Maria; Xu, Wei; Kesisoglou, Filippos; Reppas, Christos

2017-06-01

To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric dissolution of salts of weak bases. To evaluate the importance of bicarbonate buffer in biorelevant in vitro dissolution testing when using Level II biorelevant media simulating the environment in the fasted upper small intestine, regardless of gastric acid secretions. Media for simulating the hypochlorhydric and achlorhydric conditions in stomach were proposed using phosphates, maleates and bicarbonates buffers. The impact of bicarbonates in Level II biorelevant media simulating the environment in upper small intestine was evaluated so that pH and bulk buffer capacity were maintained. Dissolution data were collected using two model compounds, pioglitazone hydrochloride and semifumarate cocrystal of Compound B, and the mini-paddle dissolution apparatus in biorelevant media and in human aspirates. Simulated gastric fluids proposed in this study were in line with pH, buffer capacity, pepsin content, total bile salt/lecithin content and osmolality of the fasted stomach under partial and under complete inhibition of gastric acid secretion. Fluids simulating the conditions under partial inhibition of acid secretion were useful in simulating concentrations of both model compounds in gastric aspirates. Bicarbonates in Level III biorelevant gastric media and in Level II biorelevant media simulating the composition in the upper intestinal lumen did not improve simulation of concentrations in human aspirates. Level III biorelevant media for simulating the intragastric environment under hypochlorhydric conditions were proposed and their usefulness in the evaluation of concentrations of two model salts of weak bases in gastric aspirates was shown. Level II biorelevant media for simulating the environment in upper intestinal lumen led to

Legal aspects of sinkhole development and flooding in karst terranes: 1. Review and synthesis

NASA Astrophysics Data System (ADS)

Quinlan, James F.

1986-03-01

Structures built within the area of influence of a sinkhole can be affected by collapse, subsidence, or flooding. Unanticipated property losses may be involved, and litigation commonly ensues. Insurance compensation for damages that result from sinkhole collapse or subsidence in a karst terrane are covered by statute only in Florida and by voluntary agreement of companies operating in Tennessee Liability or insurance compensation for damages resulting from sinkhole flooding is not specifically covered by any state or federal statute. Regulations of the National Flood Insurance Program have been interpreted to allow coverage by this program for homes affected by sinkhole flooding in Bowling Green, Kentucky In the present article, case law, legal concepts of groundwater and surface water, liability, and law review articles relevant to sinkhole litigation are summarized The rationales of plaintiffs and defendants are reviewed Liability for damages have been based on allegations of negligence, breach of various water law doctrines, trespass, nuisance, loss of support, breach of contract, and implied warranty of habitability Defenses against these allegations have been based on the merits of each of them and on caveat emptor Several alternative rationales for claiming liability for losses incurred because of sinkhole development or flooding are proposed and discussed. The little-known Henderson v Wade Sand and Gravel is highly recommended as an alternative leading case that clearly and justifiably gives protection to adjacent landowners, and ties liability for damages caused by groundwater pumpage to nuisance law and related interference with property rights. Several little-known litigated cases of sinkhole development in response to groundwater pumpage will be summarized in a second article at a later date. Concepts of liability are evolving It can be expected that the professional geologist or engineer will have an increasing number of claims made against him or her

Water quality in relation to vegetative buffers around sinkholes in karst terrain

USGS Publications Warehouse

Petersen, A.; Vondracek, B.

2006-01-01

There are approximately 8,340 mapped sinkholes in karst terrain of southeast Minnesota. Most sinkholes are adjacent to row crops that likely contribute pollutants to surface waters and aquifers. Vegetated buffers can improve water quality by reducing sediment, fertilizers, pesticides, and other potential contaminants from runoff, and may benefit water quality when placed around sinkholes. We evaluated sediment, nitrogen, phosphorus, and runoff for buffers from 2.5 to 30 m (8.3 to 98 ft) wide with a spreadsheet model. We found buffers 30 m (98 ft) wide may reduce pollution by 80 percent, although buffers 15 m (49 ft) wide may be most cost effective. Buffers could contribute to goals of reducing sediment, nitrogen, and phosphorus loads in Minnesota waters. Buffers 15 m (49 ft) wide around all sinkholes would retire approximately 436 ha (1,077 ac) of land from production and cost approximately $260,000 yr-1 based on Conservation Reserve Program payments, while requiring <14 percent of the budget of the program for groundwater protection in southeast Minnesota.

Microbial communities and organic biomarkers in a Proterozoic-analog sinkhole.

PubMed

Hamilton, T L; Welander, P V; Albrecht, H L; Fulton, J M; Schaperdoth, I; Bird, L R; Summons, R E; Freeman, K H; Macalady, J L

2017-11-01

Little Salt Spring (Sarasota County, FL, USA) is a sinkhole with groundwater vents at ~77 m depth. The entire water column experiences sulfidic (~50 μM) conditions seasonally, resulting in a system poised between oxic and sulfidic conditions. Red pinnacle mats occupy the sediment-water interface in the sunlit upper basin of the sinkhole, and yielded 16S rRNA gene clones affiliated with Cyanobacteria, Chlorobi, and sulfate-reducing clades of Deltaproteobacteria. Nine bacteriochlorophyll e homologues and isorenieratene indicate contributions from Chlorobi, and abundant chlorophyll a and pheophytin a are consistent with the presence of Cyanobacteria. The red pinnacle mat contains hopanoids, including 2-methyl structures that have been interpreted as biomarkers for Cyanobacteria. A single sequence of hpnP, the gene required for methylation of hopanoids at the C-2 position, was recovered in both DNA and cDNA libraries from the red pinnacle mat. The hpnP sequence was most closely related to cyanobacterial hpnP sequences, implying that Cyanobacteria are a source of 2-methyl hopanoids present in the mat. The mats are capable of light-dependent primary productivity as evidenced by 13 C-bicarbonate photoassimilation. We also observed 13 C-bicarbonate photoassimilation in the presence of DCMU, an inhibitor of electron transfer to Photosystem II. Our results indicate that the mats carry out light-driven primary production in the absence of oxygen production-a mechanism that may have delayed the oxygenation of the Earth's oceans and atmosphere during the Proterozoic Eon. Furthermore, our observations of the production of 2-methyl hopanoids by Cyanobacteria under conditions of low oxygen and low light are consistent with the recovery of these structures from ancient black shales as well as their paucity in modern marine environments. © 2017 The Authors. Geobiology Published by John Wiley & Sons Ltd.

Rapid analysis of drug dissolution by paper spray ionization mass spectrometry.

PubMed

Liu, Yang; Liu, Ning; Zhou, Ya-Nan; Lin, Lan; He, Lan

2017-03-20

With a great quantity of solid dosage tested by dissolution technology, developing a rapid and sensitive method to access the content of drug within dissolution media is highly desired by analysts and scientists. Traditionally, dissolution media is not compatible with mass spectrometry since the inorganic salts in the media might damage the mass spectrometer. Here, paper spray ionization mass spectrometry (PSI-MS), one of the ambient mass spectrometry technologies, is developed to characterize the content of drugs in dissolution media. The porous structure of paper can effectively retain salts from entering mass spectrometer. This makes the measurement of drug content within dissolution media by mass spectrometer possible. After the experimental parameters were optimized, calibration curves of model drugs - enalapril, quinapril and benazepril were established by using corresponding deuterated internal standards. PSI-MS was then deployed to characterize the content of enalapril from the dissolution testing of enalapril tablets. The results from PSI-MS are comparable to those from HPLC characterization. More importantly, the analysis time of 6 samples is shortened from 90min to 6min. Detection limit of enalapril maleate tablets by PSI-MS is 1/300 of LC. PSI-MS is rapid, sensitive and accurate in analyzing drug content from dissolution tests. Copyright © 2016 Elsevier B.V. All rights reserved.

ANNUAL WATER BUDGETS FOR A FORESTED SINKHOLE WETLAND

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hill, Dr. Andrew Jason; Neary, Vincent S

2012-01-01

Annual water budgets spanning two years, 2004 and 2005, are constructed for a sinkhole wetland in the Tennessee Highland Rim following conversion of 13 % of its watershed to impervious surfaces. The effect of watershed development on the hydrology of the study wetland was significant. Surface runoff was the dominant input, with a contribution of 61.4 % of the total. An average of 18.9 % of gross precipitation was intercepted by the canopy and evaporated. Seepage from the surface water body to the local groundwater system accounted for 83.1 % of the total outflow. Deep recharge varied from 43.2 %more » (2004) to 12.1 % (2005) of total outflow. Overall, evapotranspiration accounted for 72.4 % of the total losses, with an average of 65.7 % lost from soil profile storage. The annual water budgets indicate that deep recharge is a significant hydrologic function performed by isolated sinkhole wetlands, or karst pans, on the Tennessee Highland Rim. Continued hydrologic monitoring of sinkhole wetlands are needed to evaluate hydrologic function and response to anthropogenic impacts. The regression technique developed to estimate surface runoff entering the wetland is shown to provide reasonable annual runoff estimates, but further testing is needed.« less

Deformation analysis of a sinkhole in Thuringia using multi-temporal multi-view stereo 3D reconstruction data

NASA Astrophysics Data System (ADS)

Petschko, Helene; Goetz, Jason; Schmidt, Sven

2017-04-01

Sinkholes are a serious threat on life, personal property and infrastructure in large parts of Thuringia. Over 9000 sinkholes have been documented by the Geological Survey of Thuringia, which are caused by collapsing hollows which formed due to solution processes within the local bedrock material. However, little is known about surface processes and their dynamics at the flanks of the sinkhole once the sinkhole has shaped. These processes are of high interest as they might lead to dangerous situations at or within the vicinity of the sinkhole. Our objective was the analysis of these deformations over time in 3D by applying terrestrial photogrammetry with a simple DSLR camera. Within this study, we performed an analysis of deformations within a sinkhole close to Bad Frankenhausen (Thuringia) using terrestrial photogrammetry and multi-view stereo 3D reconstruction to obtain a 3D point cloud describing the morphology of the sinkhole. This was performed for multiple data collection campaigns over a 6-month period. The photos of the sinkhole were taken with a Nikon D3000 SLR Camera. For the comparison of the point clouds the Multiscale Model to Model Comparison (M3C2) plugin of the software CloudCompare was used. It allows to apply advanced methods of point cloud difference calculation which considers the co-registration error between two point clouds for assessing the significance of the calculated difference (given in meters). Three Styrofoam cuboids of known dimensions (16 cm wide/29 cm high/11.5 cm deep) were placed within the sinkhole to test the accuracy of the point cloud difference calculation. The multi-view stereo 3D reconstruction was performed with Agisoft Photoscan. Preliminary analysis indicates that about 26% of the sinkhole showed changes exceeding the co-registration error of the point clouds. The areas of change can mainly be detected on the flanks of the sinkhole and on an earth pillar that formed in the center of the sinkhole. These changes describe

Salt precipitation and dissolution in the late Quaternary Dead Sea: Evidence from chemical and δ37Cl composition of pore fluids and halites

NASA Astrophysics Data System (ADS)

Levy, Elan J.; Yechieli, Yoseph; Gavrieli, Ittai; Lazar, Boaz; Kiro, Yael; Stein, Mordechai; Sivan, Orit

2018-04-01

The chemical composition and δ37Cl of pore fluids from the ICDP core drilled in the deepest floor of the terminal and hypersaline Dead Sea, and halites from the adjacent Mount Sedom salt diapir, are used to establish the dynamics of halite precipitation and dissolution during the last interglacial and glacial periods. Between ∼132 and 116 thousand years ago (ka) halites precipitated in the lake resulting in the expulsion of Na+ and Cl- from the residual solution. Over 50% of the Cl- reservoir was removed, resulting in a decrease in the Na/Cl ratio from 0.57 to 0.19. This process was accompanied by a decrease in δ37Cl values in the precipitating halites and the associated residual Cl- in the lake. The observed decrease fits a Rayleigh distillation curve with a fractionation factor of Δ(NaCl-Dead Sea solution) = +0.32‰ (±0.12) determined in the present study. This behavior implies negligible contribution of external sources of Cl- to the lake during the main peak of the last interglacial, MIS5e. Subsequently, during the last glacial (ca. 117 to 17 ka) dissolution of halite took place, the Na+ and Cl- inventory were replenished, accompanied by an increase in Na/Cl from 0.21 to 0.55 and in the δ37Cl values from -0.46‰ to -0.12‰. While the lake underwent significant dilution during that time, the decrease in salinity was somewhat suppressed by the dissolution of the halite which was mostly derived from Mount Sedom salt diapir.

Karst Lands: The dissolution of carbonate rock produces unique landscapes and poses significant hydrological and environmental concerns

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, W.B.; Culver, D.C.; Herman, J.S.

1995-09-01

Karst lands are produced by the action of water on soluble rocks, a process among the most dynamic of all erosive forces that counterbalance the uplifting forces of tectonics. The dissolution of carbonate rock, primarily limestone and dolomite, produces unique landscapes and poses significant hydrological and environmental concerns. The major topic areas discussed in this article include the following: processes that form karst; karst drainage basins; discharge from karst aquifers; caves as paleoclimatic recorders; caves as ecosystems; water issues in karst regions; and sinkholes, soil piping and subsidence. 20 refs., 9 figs.

Karst in evaporite rocks of the United States

USGS Publications Warehouse

Johnson, Kenneth S.

2002-01-01

Evaporites are the most soluble of common rocks; they are dissolved readily to form the same range of karst features that typically are found in limestones and dolomites. Evaporites, including gypsum (or anhydrite) and salt, are present in 32 of the 48 contiguous United States, and they underlie about 35-40% of the land area. Evaporite outcrops typically contain sinkholes, caves, disappearing streams, and springs. Other evidence of active karst in evaporites includes surface-collapse features and saline springs or saline plumes that result from dissolution of salt. Many evaporites, including some in the deeper subsurface, also contain evidence of paleokarst that is no longer active; this evidence includes dissolution breccias, breccia pipes, slumped beds, and collapse structures. Evaporites occur in 24 separate structural basins or geographic districts in the United States, and either local or extensive evaporite karst is known in almost all of these basins or districts. Human activities also have caused development of evaporite karst, primarily in salt deposits. Boreholes or underground mines may enable (either intentionally or inadvertently) unsaturated water to flow through or against salt deposits, thus allowing development of small to large dissolution cavities. If the dissolution cavity is large enough and shallow enough, successive roof failures can cause land subsidence or catastrophic collapse. Evaporite karst, both natural and human-induced, is far more prevalent than commonly believed.

Application Of Two Dimensional Electrical Resistivity Tomography Method For Delineating Cavities And Flowpath In Sinkhole Prone Area Of Armala Valley, Pokhara, Western Nepal

NASA Astrophysics Data System (ADS)

Bhusal, U. C.; Dwivedi, S.; Ghimire, H.; Ulak, P. D.; Khatiwada, B.; Rijal, M. L.; Neupane, Y.; Aryal, S.; Pandey, D.; Gautam, A.; Mishra, S.

2017-12-01

a depth of 7 m. Undulations in the interface between gravel layer and underlying clayey silt layer, infiltration of acidic fluid, formation of fissures, cracks and dissolution, piping in the clayey silt layer increased the size of cavity, encroachment of Duhani Khola channel, rapid deepening of the Kali Khola are major causes for formation of sinkholes in Armala Valley.

Near-surface gas mapping studies of salt geologic features at Weeks Island and other sites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molecke, M.A.; Carney, K.R.; Autin, W.J.

1996-10-01

Field sampling and rapid gas analysis techniques were used to survey near-surface soil gases for geotechnical diagnostic purposes at the Weeks Island Strategic Petroleum Reserve (SPR) site and other salt dome locations in southern Louisiana. This report presents the complete data, results and interpretations obtained during 1995. Weeks Island 1994 gas survey results are also briefly summarized; this earlier study did not find a definitive correlation between sinkhole No. 1 and soil gases. During 1995, several hundred soil gas samples were obtained and analyzed in the field by gas chromatography, for profiling low concentrations and gas anomalies at ppm tomore » percent levels. The target gases included hydrogen, methane, ethane and ethylene. To supplement the field data, additional gas samples were collected at various site locations for laboratory analysis of target gases at ppb levels. Gases in the near-surface soil originate predominantly from the oil, from petrogenic sources within the salt, or from surface microbial activity. Surveys were conducted across two Weeks Island sinkholes, several mapped anomalous zones in the salt, and over the SPR repository site and its perimeter. Samples were also taken at other south Louisiana salt dome locations for comparative purposes. Notable results from these studies are that elevated levels of hydrogen and methane (1) were positively associated with anomalous gassy or shear zones in the salt dome(s) and (2) are also associated with suspected salt fracture (dilatant) zones over the edges of the SPR repository. Significantly elevated areas of hydrogen, methane, plus some ethane, were found over anomalous shear zones in the salt, particularly in a location over high pressure gas pockets in the salt, identified in the mine prior to SPR operations. Limited stable isotope ratio analyses, SIRA, were also conducted and determined that methane samples were of petrogenic origin, not biogenic.« less

Modeling Episodic Ephemeral Brine Lake Evaporation and Salt Crystallization on the Bonneville Salt Flats, Utah

NASA Astrophysics Data System (ADS)

Liu, T.; Harman, C. J.; Kipnis, E. L.; Bowen, B. B.

2017-12-01

Public concern about apparent reductions in the areal extent of the Bonneville Salt Flat (BSF) and perceived changes in inundation frequency has motivated renewed interest in the hydrologic and geochemical behavior of this salt playa. In this study, we develop a numerical modeling framework to simulate the relationship between hydrometeorologic variability, brine evaporation and salt crystallization processes on BSF. The BSF, locates in Utah, is the remnant of paleo-lake Bonneville, and is capped by up to 1 meter of salt deposition over a 100 km2 area. The BSF has two distinct hydrologic periods each year: a winter wet periods with standing surface brine and the summer dry periods when the brine is evaporated, exposing the surface salt crust. We develop a lumped non-linear dynamical models coupling conservation expressions from water, dissolved salt and thermal energy to investigate the seasonal and diurnal behavior of brine during the transition from standing brine to exposed salt at BSF. The lumped dynamic models capture important nonlinear and kinetic effects introduced by the high ionic concentration of the brine, including the pronounced effect of the depressed water activity coefficient on evaporation. The salt crystallization and dissolution rate is modeled as a kinetic process linearly proportional to the degree of supersaturation of brine. The model generates predictions of the brine temperature and the solute and solvent masses controlled by diurnal net radiation input and aerodynamic forcing. Two distinct mechanisms emerge as potential controls on salt production and dissolution: (1) evapo-concentration and (2) changes in solubility related to changes in brine temperature. Although the evaporation of water is responsible for ultimate disappearance of the brine each season ,variation in solubility is found to be the dominant control on diurnal cycles of salt precipitation and dissolution in the BSF case. Most salt is crystallized during nighttime, but the

Bayou Corne sinkhole : control measurements of State Highway 70 in Assumption Parish, Louisiana, tech summary.

DOT National Transportation Integrated Search

2014-01-01

The sinkhole located in Assumption Parish, Louisiana, threatens the stability of Highway 70, a state maintained route. In order to : mitigate the potential damaging e ects of the sinkhole on this infrastructure, the Louisiana Department of Transpo...

Relationships between sinkholes areal distribution and main tectonic alignments in Abruzzo (Central Italy)

NASA Astrophysics Data System (ADS)

Ferrini, G.; Moretti, A.; De Rose, C.; Stagnini, E.,; Serafini, M.

2012-04-01

Intermountain basins, developed at the back side of the Apennines overturning front, are the most evident morphological expressions of extensional tectonics in Central Italy and can be recognized in many different sections of the chain. L'Aquila basin and the adjoining Subequana valley are part of a single NW-SE elongated depression (about 60 km long) which began to develop about in the early Quaternary in response to the identification of various regional extensional tectonic alignments and the consequent starting of the basin subsidence. This impressive morphological element is characterized by the presence of several large funnel-shaped features (locally named Fosse = trench) which affect mainly the Meso-Cenozoic carbonatic bedrock but also the Neogenic clastic sedimentary filling of the valley. Some of these last elements are often occupied by ponds or significant artesian water resurgences like the Sinizzo Lake where, during L'Aquila earthquake of April 6th 2009, the shores collapsed and strong microseismic activity, deep rumbles and flow rate changes were reported for the following months. The Fosse mapped in the L'Aquila basin have widths in the order of hundreds of meters, a considerable difference of elevation respect the rims and present a general morphology very close to that of the classic dissolution karst sinkholes. Their evolution/localization is strictly related to the active fault systems which controls also the main tracts of the relief; the low volume of residual sedimentary deposits within the depression, not comparable with the total volume of rock removed, indicates that surface karst dissolution phenomena are absent or secondary. The elevations of the floor of many Fosse are higher respect the actual flood plain depending on their age; in fact relict circular forms, recognizable at upper altitude on the relief slope, confirm that the phenomenon has been active for a considerable period of time. About the genesis of this features, even if at

Definition of a Sinkhole hazard methodology in the Pontina Plain (Latium Region, Central Italy)

NASA Astrophysics Data System (ADS)

Teoli, Pamela; Mazza, Roberto; Capelli, Giuseppe

2010-05-01

The work presented here is the continuation of " Sinkhole Project of Latium Region" (2002), carried out by Researchers of the Laboratory of Applied Geology and Hydrogeology of the Department of Geological Sciences of the University "Roma Tre", Rome (Italy), through which were found, in different plain of the whole Region, Sinkhole prone areas, using a methodology based on the superimposition of thematic layers corresponding to geological and anthropogenic breaking factors. In the last years several specific investigations have been conducted by Researchers of the Laboratory in the Pontina Plain, that is located in the south west of the Latium Region, concerning the geological-stratigraphic setting, the sketch of flow in the aquifers located in the Pontine depression, the chemiphysical groundwater characheteristics, the density of wells, the amount of well pumping and piezometric changes. This required the implementation of several piezometric and chemiphysical surveys, the collection and validation of a large number of stratigraphic and geophysical data. All data in the archive have been computerized and the maps vectorized. This makes it possible today to address the analysis with Geographical Information Systems and to start numerical flow simulations, regarding both the heavily drained deep confined aquifer, and the areas subject to the presence of an important water exchange between the recharge area in the Lepini Mountains (carbonatic ridge) and terrigenous aquifers of the plain. Among the main causes that trigger the catastrophic collapses there are, in fact, all the phenomena that cause the mass density reduction through erosion, leaching, dissolution. All these agents are associated with water circulation: flow, velocity, CO2 saturation rate, carbonates saturation rate. The spread in the Pontina plain of deep and high pumping wells, wrongly built without the correct way of progress, and without the realization of cemented portions properly located, can lead

Environmental consequences of the Retsof Salt Mine roof collapse

USGS Publications Warehouse

Yager, Richard M.

2013-01-01

In 1994, the largest salt mine in North America, which had been in operation for more than 100 years, catastrophically flooded when the mine ceiling collapsed. In addition to causing the loss of the mine and the mineral resources it provided, this event formed sinkholes, caused widespread subsidence to land, caused structures to crack and subside, and changed stream flow and erosion patterns. Subsequent flooding of the mine drained overlying aquifers, changed the groundwater salinity distribution (rendering domestic wells unusable), and allowed locally present natural gas to enter dwellings through water wells. Investigations including exploratory drilling, hydrologic and water-quality monitoring, geologic and geophysical studies, and numerical simulation of groundwater flow, salinity, and subsidence have been effective tools in understanding the environmental consequences of the mine collapse and informing decisions about management of those consequences for the future. Salt mines are generally dry, but are susceptible to leaks and can become flooded if groundwater from overlying aquifers or surface water finds a way downward into the mined cavity through hundreds of feet of rock. With its potential to flood the entire mine cavity, groundwater is a constant source of concern for mine operators. The problem is compounded by the viscous nature of salt and the fact that salt mines commonly lie beneath water-bearing aquifers. Salt (for example halite or potash) deforms and “creeps” into the mined openings over time spans that range from years to centuries. This movement of salt can destabilize the overlying rock layers and lead to their eventual sagging and collapse, creating permeable pathways for leakage of water and depressions or openings at land surface, such as sinkholes. Salt is also highly soluble in water; therefore, whenever water begins to flow into a salt mine, the channels through which it flows increase in diameter as the surrounding salt dissolves

Sinkhole Susceptibility Hazard Zones Using GIS and Analytical Hierarchical Process (ahp): a Case Study of Kuala Lumpur and Ampang Jaya

NASA Astrophysics Data System (ADS)

Rosdi, M. A. H. M.; Othman, A. N.; Zubir, M. A. M.; Latif, Z. A.; Yusoff, Z. M.

2017-10-01

Sinkhole is not classified as new phenomenon in this country, especially surround Klang Valley. Since 1968, the increasing numbers of sinkhole incident have been reported in Kuala Lumpur and the vicinity areas. As the results, it poses a serious threat for human lives, assets and structure especially in the capital city of Malaysia. Therefore, a Sinkhole Hazard Model (SHM) was generated with integration of GIS framework by applying Analytical Hierarchical Process (AHP) technique in order to produced sinkhole susceptibility hazard map for the particular area. Five consecutive parameters for main criteria each categorized by five sub classes were selected for this research which is Lithology (LT), Groundwater Level Decline (WLD), Soil Type (ST), Land Use (LU) and Proximity to Groundwater Wells (PG). A set of relative weights were assigned to each inducing factor and computed through pairwise comparison matrix derived from expert judgment. Lithology and Groundwater Level Decline has been identified gives the highest impact to the sinkhole development. A sinkhole susceptibility hazard zones was classified into five prone areas namely very low, low, moderate, high and very high hazard. The results obtained were validated with thirty three (33) previous sinkhole inventory data. This evaluation shows that the model indicates 64 % and 21 % of the sinkhole events fall within high and very high hazard zones respectively. Based on this outcome, it clearly represents that AHP approach is useful to predict natural disaster such as sinkhole hazard.

Automated sinkhole detection using a DEM subsetting technique and fill tools at Mammoth Cave National Park

NASA Astrophysics Data System (ADS)

Wall, J.; Bohnenstiehl, D. R.; Levine, N. S.

2013-12-01

An automated workflow for sinkhole detection is developed using Light Detection and Ranging (Lidar) data from Mammoth Cave National Park (MACA). While the park is known to sit within a karst formation, the generally dense canopy cover and the size of the park (~53,000 acres) creates issues for sinkhole inventorying. Lidar provides a useful remote sensing technology for peering beneath the canopy in hard to reach areas of the park. In order to detect sinkholes, a subsetting technique is used to interpolate a Digital Elevation Model (DEM) thereby reducing edge effects. For each subset, standard GIS fill tools are used to fill depressions within the DEM. The initial DEM is then subtracted from the filled DEM resulting in detected depressions or sinkholes. Resulting depressions are then described in terms of size and geospatial trend.

Use of sinkhole and specific capacity distributions to assess vertical gradients in a karst aquifer

USGS Publications Warehouse

McCoy, K.J.; Kozar, M.D.

2008-01-01

The carbonate-rock aquifer in the Great Valley, West Virginia, USA, was evaluated using a database of 687 sinkholes and 350 specific capacity tests to assess structural, lithologic, and topographic influences on the groundwater flow system. The enhanced permeability of the aquifer is characterized in part by the many sinkholes, springs, and solutionally enlarged fractures throughout the valley. Yet, vertical components of subsurface flow in this highly heterogeneous aquifer are currently not well understood. To address this problem, this study examines the apparent relation between geologic features of the aquifer and two spatial indices of enhanced permeability attributed to aquifer karstification: (1) the distribution of sinkholes and (2) the occurrence of wells with relatively high specific capacity. Statistical results indicate that sinkholes (funnel and collapse) occur primarily along cleavage and bedding planes parallel to subparallel to strike where lateral or downward vertical gradients are highest. Conversely, high specific capacity values are common along prominent joints perpendicular or oblique to strike. The similarity of the latter distribution to that of springs suggests these fractures are areas of upward-convergent flow. These differences between sinkhole and high specific capacity distributions suggest vertical flow components are primarily controlled by the orientation of geologic structure and associated subsurface fracturing. ?? 2007 Springer-Verlag.

The preparation and evaluation of salt forms of linogliride with reduced solubilities as candidates for extended release.

PubMed

Chrzanowski, Frank A; Ahmad, Kaleem

2017-03-01

Salts of linogliride with reduced solubilities were prepared and evaluated as potential candidates for extended-release oral dosage forms. A once-daily dose of 300-800 mg was intended. Seven acids were selected: p-acetamidobenzoic, benzoic, p-hydroxybenzoic, 3-hydroxy-2-naphthoic, 1-napsylic, pamoic, and p-toluenesulfonic acids but only four salts were able to be prepared in suitable quantities for evaluation: linogliride pamoate, p-hydroxybenzoate, 3-hydroxy-2-naphthoate, and 1-napsylate. The pH-solubility profiles of the four new salts, free base, and fumarate salt were compared over the pH 1.43-8.3 range and the intrinsic dissolution rates of the four new salts and the free base were determined at pH 1.43, 4.4, and 7.5. The range of the pH-solubility profile and intrinsic dissolution rates of the p-hydroxybenzoate salt were less than the free base and fumarate and higher than the other three new salts. The pH-solubilities and intrinsic dissolution rates of the 1-napsylate salt were pH-independent. The solubilities and intrinsic dissolution rates of the pamoate and 3-hydroxy-2-naphthoate were higher at pH 1.4-3.4 than at higher pH. At pH 4.4 and higher, the solubilities were essentially the same, in the 1-2 mg/mL range. The intrinsic dissolution rates were also very low and not very different. Dissolution studies with capsules containing 800 mg doses of the pamoate, 1-napsylate, free base, and fumarate performed in a dissolution medium of pH beginning at 2.2 and ending at 6.8 demonstrated that the pamoate and 1-napsylate salt forms dissolved slower and could be useful as extended-release forms.

Dissolution-Enlarged Fractures Imaging Using Electrical Resistivity Tomography (ERT)

NASA Astrophysics Data System (ADS)

Siami-Irdemoosa, Elnaz

In recent years the electrical imaging techniques have been largely applied to geotechnical and environmental investigations. These techniques have proven to be the best geophysical methods for site investigations in karst terrain, particularly when the overburden soil is clay-dominated. Karst is terrain with a special landscape and distinctive hydrological system developed by dissolution of rocks, particularly carbonate rocks such as limestone and dolomite, made by enlarging fractures into underground conduits that can enlarge into caverns, and in some cases collapse to form sinkholes. Bedding planes, joints, and faults are the principal structural guides for underground flow and dissolution in almost all karstified rocks. Despite the important role of fractures in karst development, the geometry of dissolution-enlarged fractures remain poorly unknown. These features are characterized by an strong contrast with the surrounding formations in terms of physical properties, such as electrical resistivity. Electrical resistivity tomography (ERT) was used as the primary geophysical tool to image the subsurface in a karst terrain in Greene County, Missouri. Pattern, orientation and density of the joint sets were interpreted from ERT data in the investigation site. The Multi-channel Analysis of Surface Wave (MASW) method and coring were employed to validate the interpretation results. Two sets of orthogonal visually prominent joints have been identified in the investigation site: north-south trending joint sets and west-east trending joint sets. However, most of the visually prominent joint sets are associated with either cultural features that concentrate runoff, natural surface drainage features or natural surface drainage.

[Transport and differentiation of polycyclic aromatic hydrocarbons in air from Dashiwei karst Sinkholes in Guangxi, China].

PubMed

Kong, Xiang-Sheng; Qi, Shi-Hua; Sun, Qian; Huang, Bao-Jian

2012-12-01

The typical karst Dashiwei Sinkholes located in Leye County, Guangxi were chosen as the study object. The air samples from the opening of Dashiwei Sinkholes to the underground river profiles were collected by polyurethane foam passive samplers (PUF-PAS), and the meteorological parameters were observed. The 16 PAHs were analyzed using GC-MS. The results showed that the total PAHs concentration in air in Dashiwei Sinkholes ranged from 33.76 ng x d(-1) to 150.86 ng x d(-1), with an average of 80.36 ng x d(-1). The mean concentrations in the cliff, the bottom and the underground river profiles were 67.17, 85.36 and 101.67 ng x d(-1), respectively. The 2-3 rings PAHs (including phenanthrene, anthracene, napnthalene and fluorene) accounted for 87.97% of the total of PAHs. The transport and accumulation processes of PAHs in air in Dashiwei Sinkholes were: the ground to the cliff section to the bottom section and then to the underground river, and the total PAHs concentrations showed an obvious increasing tendency with the decrease in altitude or increase in the length of the underground river. Low molecular weight PAHs compounds (including phenanthrene, anthracene, flourene and fluoranthene) in air went through differentiation at the bottom of the west peak, the bottom of the sinkhole and the underground river. The primary sources of PAHs were pyrogenic sources with atmosphere transport. Ambient temperature was the predominating factor influencing the transport and accumulation of gas phase PAHs in Dashiwei Sinkholes, following by wind speed, wind direction and relative humidity. Relative humidity and the temperature were the predominating factors influencing the differentiation, following by wind speed and wind direction. As a whole, a "cold trapping effect" of POPs was showed obviously in Dashiwei Sinkholes.

Minimum Temperatures, Diurnal Temperature Ranges and Temperature Inversions in Limestone Sinkholes of Different Sizes and Shapes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whiteman, Charles D.; Haiden, Thomas S.; Pospichal, Bernhard

2004-08-01

Air temperature data from five enclosed limestone sinkholes of various sizes and shapes on the 1300 m MSL Duerrenstein Plateau near Lunz, Austria have been analyzed to determine the effect of sinkhole geometry on temperature minima, diurnal temperature ranges, temperature inversion strengths and vertical temperature gradients. Data were analyzed for a non-snow-covered October night and for a snow-covered December night when the temperature fell as low as -28.5°C. Surprisingly, temperatures were similar in two sinkholes with very different drainage areas and depths. A three-layer model was used to show that the sky-view factor is the most important topographic parameter controllingmore » cooling for basins in this size range and that the cooling slows when net longwave radiation at the floor of the sinkhole is nearly balanced by the ground heat flux.« less

Assessment of oral bioavailability enhancing approaches for SB-247083 using flow-through cell dissolution testing as one of the screens.

PubMed

Perng, Cherng-Yih; Kearney, Albert S; Palepu, Nagesh R; Smith, Brian R; Azzarano, Leonard M

2003-01-02

SB-247083 is a potent, nonpeptidic, orally active, ETA-selective, endothelin receptor antagonist. The diacid form and three salts (monoarginine, diarginine and disodium) of SB-247083 were evaluated during the pre-clinical phase of development. The developability attributes (i.e. hygroscopicity, thermal behavior, aqueous solubility, and drug-excipient compatibility) of these compounds were evaluated. In addition to these attributes, the flow-through cell (FTC) dissolution testing (using USP Apparatus 4) was used as a screening technique to evaluate several SB-247083 formulations of the diacid and its salts. FTC dissolution testing offers two distinct advantages over the more traditional static-condition dissolution testing: (1) maintenance of sink conditions; and (2) the ability to change the dissolution medium during a dissolution run. The former advantage is especially important for poorly aqueous soluble drugs having associated dissolution-rate-limitations, and the latter advantage allows one to more closely simulate the pH gradient associated with transit through the GI tract. Based on the comparative dissolution data, three formulations were chosen for oral dosing in dogs. The reasonable correlation found between the FTC dissolution results and the oral bioavailability data demonstrate that FTC dissolution testing can be a valuable tool for aiding in salt (solid-state form) and formulation selection in the early stages of development of drug candidates.

Multi-modality imaging findings of huge intrachoroidal cavitation and myopic peripapillary sinkhole.

PubMed

Chen, Yutong; Ma, Xiaoli; Hua, Rui

2018-02-02

Peripapillary intrachoroidal cavitation was described as the presence of an asymptomatic, well-circumscribed, yellow-orange, peripapillary lesion at the inferior border of the myopic conus in eyes with high myopia. A 66-year-old myopic Chinese man was enrolled and his multi-color imaging examination showed a well-circumscribed, caesious, peripapillary lesion coalesced with the optic nerve head vertically rotated and obliquely tilted, together with an inferotemporal sinkhole in the myopic conus. The optical coherence tomography images showed an intrachoroidal hyporeflective space, schisis, an intracavitary septum located below the retinal pigment epithelium and inserted beneath the optic nerve head, as well as a sinkhole between the peripapillary intrachoroidal cavitation and the vitreous space. Both myopic colobomas and sinkhole in myopic conus may contribute the coalescence of intrachoroidal cavitation with optic nerve head. These qualitative and quantitative new findings will be beneficial for understanding its pathomorphological mechanism, and the impact on optic nerve tissue of myopic patients.

Inception horizon concept as a basis for sinkhole hazard mapping

NASA Astrophysics Data System (ADS)

Vouillamoz, J.; Jeannin, P.-Y.; Kopp, L.; Chantry, R.

2012-04-01

The office for natural hazards of the Vaud canton (Switzerland) is interested for a pragmatic approach to map sinkhole hazard in karst areas. A team was created by merging resources from a geoengineering company (CSD) and a karst specialist (SISKA). Large areas in Vaud territory are limestone karst in which the collapse hazard is essentially related to the collapse of soft-rocks covering underground cavities, rather than the collapse of limestone roofs or underground chambers. This statement is probably not valid for cases in gypsum and salt. Thus, for limestone areas, zones of highest danger are voids covered by a thin layer of soft-sediments. The spatial distributions of void and cover-thickness should therefore be used for the hazard assessment. VOID ASSESSMENT Inception features (IF) are millimetre to decimetre thick planes (mainly bedding but also fractures) showing a mineralogical, a granulometrical or a physical contrast with the surrounding formation that make them especially susceptible to karst development (FILIPPONI ET AL., 2009). The analysis of more than 1500 km of cave passage showed that karst conduits are mainly developed along such discrete layers within a limestone series. The so-called Karst-ALEA method (FILIPPONI ET AL., 2011) is based on this concept and aims at assessing the probability of karst conduit occurrences in the drilling of a tunnel. This approach requires as entries the identification of inception features (IF), the recognition of paleo-water-table (PWT), and their respective spatial distribution in a 3D geological model. We suggest the Karst-ALEA method to be adjusted in order to assess the void distribution in subsurface as a basis for sinkhole hazard mapping. Inception features (horizons or fractures) and paleo-water-tables (PWT) have to be first identified using visible caves and dolines. These features should then be introduced into a 3D geological model. Intersections of HI and PWT located close to landsurface are areas with a

Planning of geological investigations in areas affected by anthropogenic sinkholes: the case of densely urbanised area northeast of Naples (Italy)

NASA Astrophysics Data System (ADS)

Guarino, Paolo Maria; Santo, Antonio

2013-04-01

In the last years, many studies about sinkholes have been produced. These sudden phenomena can be generated from natural or artificial causes: the first ones are developed in soluble rocks like carbonate or sulphates, the second are linked to the presence of artificial caves or mines. In Italy both the typologies are widely present, but more often the anthropogenic sinkholes are cause of most damages and fatalities, because many ancient city center were built using the local rock, giving rise to complex and widespread networks of underground cavities, whose collapse brings about the formation of sinkholes. Examples are the Lazio, Toscana, Umbria, Campania, Puglia and Sicily regions, where important towns like Rome, Naples and Palermo are frequently affected by sinkholes. Identifying and analyzing natural and anthropogenic predisposing and triggering factors are essential steps for evaluating susceptibility to sinkholes; nevertheless, the susceptibility zoning must be considered the starting point towards further detailed studies. This study aims to provide a contribution to the definition of a more accurate planning of geological studies at the municipality scale, in order to mitigate the risk in densely urbanized areas affected by anthropogenic sinkholes. The considered study area includes the metropolitan area northeast of Naples (Italy), where sinkholes are very frequent because of the widespread presence of artificial caves dug in pyroclastic rocks. In a first phase, data and information relative to stratigraphic logs, presence and distribution of cavities and sinkholes phenomena were collected and organized in a GIS associated database. Thereafter, the processing of contour maps of tuff top surface and caves depth has been realized, as well as fully detailed cross sections, in order to recognize different characteristics and genesis of sinkholes. At the end, with reference to high susceptibility areas, a list of possible geological surveys and monitoring

Crystal forms of the hydrogen oxalate salt of o-desmethylvenlafaxine.

PubMed

Dichiarante, Elena; Curzi, Marco; Giaffreda, Stefano L; Grepioni, Fabrizia; Maini, Lucia; Braga, Dario

2015-06-01

To prepare new crystalline forms of the antidepressant o-desmethylvenlafaxine salt as potential new commercial forms and evaluate their physicochemical properties, in particular the dissolution rate. A new hydrogen oxalate salt of o-desmethylvenlafaxine hydrogen oxalate (ODV-OX) was synthesized, and a polymorph screening was performed using different solvents and crystallization conditions. Crystalline forms were characterized by a combination of solid-state techniques: X-ray powder diffraction, differential scanning calorimetry, thermogravimetric analysis, FT-IR spectroscopy and single crystal X-ray diffraction. The stability of all crystalline phases was tested under International Conference on Harmonisation (ICH) conditions (40°C and 75% Relative Humidity (RH)) for 1 week. Dissolution tests were performed on the hydrogen oxalate salt ODV-OX Form 1 and compared with dissolution test on the commercial form of the succinate salt of o-desmethylvenlafaxine. Five crystalline forms of ODV-OX were isolated, namely three hydrated forms (Form 1, Form 2, Form 3) and two anhydrous forms (Form 4 and Form 5). Comparative solubility tests on ODV-OX Form 1 and o-desmethylvenlafaxine succinate evidenced a significant increase in solubility for the hydrogen oxalate salt (142 g/l) with respect to the succinate salt (70 g/l). © 2015 Royal Pharmaceutical Society.

Benthic bacterial diversity in submerged sinkhole ecosystems.

PubMed

Nold, Stephen C; Pangborn, Joseph B; Zajack, Heidi A; Kendall, Scott T; Rediske, Richard R; Biddanda, Bopaiah A

2010-01-01

Physicochemical characterization, automated ribosomal intergenic spacer analysis (ARISA) community profiling, and 16S rRNA gene sequencing approaches were used to study bacterial communities inhabiting submerged Lake Huron sinkholes inundated with hypoxic, sulfate-rich groundwater. Photosynthetic cyanobacterial mats on the sediment surface were dominated by Phormidium autumnale, while deeper, organically rich sediments contained diverse and active bacterial communities.

Anthropogenic sinkholes in the territory of the city of Naples (Southern Italy)

NASA Astrophysics Data System (ADS)

Guarino, Paolo M.; Nisio, Stefania

About 190 anthropogenic sinkholes occurred within the territory of the city of Naples (Southern Italy) between 1915 and 2010. In the study area, the genesis of sinkholes can be ascribed to two major factors, often strongly interacting with each other: the existence of a complex network of underground man-made cavities, and the inadequacy of the sewage disposal system. Rainfall has been identified as the main triggering factor combined with anthropogenic activity. Based on such predisposing factors, in addition to the geological setting, a susceptibility map of the territory has been realised.

Identification of karst sinkholes in a forested karst landscape using airborne laser scanning data and water flow analysis

NASA Astrophysics Data System (ADS)

Hofierka, Jaroslav; Gallay, Michal; Bandura, Peter; Šašak, Ján

2018-05-01

Karst sinkholes (dolines) play an important role in a karst landscape by controlling infiltration of surficial water, air flow or spatial distribution of solar energy. These landforms also present a limiting factor for human activities in agriculture or construction. Therefore, mapping such geomorphological forms is vital for appropriate landscape management and planning. There are several mapping techniques available; however, their applicability can be reduced in densely forested areas with poor accessibility and visibility of the landforms. In such conditions, airborne laser scanning (ALS) provides means for efficient and accurate mapping of both land and landscape canopy surfaces. Taking the benefits of ALS into account, we present an innovative method for identification and evaluation of karst sinkholes based on numerical water flow modelling. The suggested method was compared to traditional techniques for sinkhole mapping which use topographic maps and digital terrain modelling. The approach based on simulation of a rainfall event very closely matched the reference datasets derived by manual inspection of the ALS digital elevation model and field surveys. However, our process-based approach provides advantage of assessing the magnitude how sinkholes influence concentration of overland water flow during extreme rainfall events. This was performed by calculating the volume of water accumulated in sinkholes during the simulated rainfall. In this way, the influence of particular sinkholes on underground geomorphological systems can be assessed. The method was demonstrated in a case study of Slovak Karst in the West Carpathians where extreme rainfalls or snow-thaw events occur annually. We identified three spatially contiguous groups of sinkholes with a different effect on overland flow concentration. These results are discussed in relation to the known underground hydrological systems.

Spatial analysis for susceptibility of second-time karst sinkholes: A case study of Jili Village in Guangxi, China

NASA Astrophysics Data System (ADS)

Zhou, Guoqing; Yan, Hongbo; Chen, Kunhua; Zhang, Rongting

2016-04-01

After a big karst sinkhole happened in Jili Village of Guangxi, China, the local government was eager to quantitatively analyze and map susceptible areas of the potential second-time karst sinkholes in order to make timely decisions whether the residents living in the first-time sinkhole areas should move. For this reason, karst sinkholes susceptibility geospatial analysis is investigated using multivariate spatial data, logistic regression model (LRM) and Geographical Information System (GIS). Ten major karst sinkholes related factors, including (1) formation lithology, (2) soil structure, (3) profile curvature, (4) groundwater depth, (5) fluctuation of groundwater level, (6) percolation rate of soil, (7) degree of karst development, (8) distance from fault, (9) distance from the traffic route, and (10) overburden thickness were selected, and then each of factors was classified and quantitated with the three or four levels. The LRM was applied to evaluate which factor makes significant contributions to sinkhole. The results demonstrated that formation lithology, soil structure, profile curvature, groundwater depth, ground water level, percolation rate of soil, and degree of karst development, the distance from fault, and overburden thickness are positive, while one factor, the distance from traffic routes is negative, which is deleted from LRM model. The susceptibility of the potential sinkholes in the study area is estimated and mapped using the solved impact factors. The susceptible degrees of the study area are classified into five levels, very high, high, moderate, low, and ignore susceptibility. It has been found that that both very high and high susceptibility areas are along Datou Hill and the foothills of the study area. This finding is verified by field observations. With the investigations conducted in this paper, it can be concluded that the susceptibility maps produced in this paper are reliable and accurate, and useful as a reference for local

A mathematical model for simulating spring discharge and estimating sinkhole porosity in a karst watershed

NASA Astrophysics Data System (ADS)

Li, Guangquan; Field, Malcolm S.

2014-03-01

Documenting and understanding water balances in a karst watershed in which groundwater and surface water resources are strongly interconnected are important aspects for managing regional water resources. Assessing water balances in karst watersheds can be difficult, however, because karst watersheds are so very strongly affected by groundwater flows through solution conduits that are often connected to one or more sinkholes. In this paper we develop a mathematical model to approximate sinkhole porosity from discharge at a downstream spring. The model represents a combination of a traditional linear reservoir model with turbulent hydrodynamics in the solution conduit connecting the downstream spring with the upstream sinkhole, which allows for the simulation of spring discharges and estimation of sinkhole porosity. Noting that spring discharge is an integral of all aspects of water storage and flow, it is mainly dependent on the behavior of the karst aquifer as a whole and can be adequately simulated using the analytical model described in this paper. The model is advantageous in that it obviates the need for a sophisticated numerical model that is much more costly to calibrate and operate. The model is demonstrated using the St. Marks River Watershed in northwestern Florida.

Bench Scale Saltcake Dissolution Test Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

BECHTOLD, D.B.; PACQUET, E.A.

A potential scenario for retrieving saltcake from single shell tanks is the ''Rainbird{reg_sign} sprinkler'' method. Water is distributed evenly across the surface of the saltcake and allowed to percolate by gravity through the waste. The salt dissolves in the water, forming a saturated solution. The saturated liquid is removed by a saltwell pump situated near the bottom of the tank. By this method, there is never a large inventory of liquid in the tank that could pose a threat of leakage. There are many variables or factors that can influence the hydrodynamics of this retrieval process. They include saltcake porosity;more » saltwell pumping rate; salt dissolution chemistry; factors that could promote flow channeling (e.g. tank walls, dry wells, inclusions or discontinuities in the saltcake); method of water distribution; plug formation due to crystal formations or accumulation of insoluble solids. A brief literature search indicates that very little experimental data exist on these aspects of saltcake dissolution (Wiersma 1996, 1997). The tests reported here were planned (Herting, 2000) to provide preliminary data and information for planning future, scaled-up tests of the sprinkler method.« less

Detection of Sinkhole Activity in Central Florida with High Spatial-Resolution InSAR Time Series Observations

NASA Astrophysics Data System (ADS)

Oliver-Cabrera, T.; Wdowinski, S.; Kruse, S.

2016-12-01

Central Florida's thick carbonate deposits and hydrological conditions make the area prone to sinkhole development. Sinkhole collapse is a major geologic hazard, threatening human life and causing substantial damage to property. Detecting sinkhole deformation before a collapse is a difficult task, due to small and typically unnoticeable surface changes. Most techniques used to map sinkholes, such as ground penetrating radar, require ground contact and are practical for localized (typically 2D, tens to hundreds of meters) surveys but not for broad study areas. In this study we use Persistent Scatterer (PS) time series analysis of Interferometric Synthetic Aperture Radar (InSAR), which is a very useful technique for detecting localized deformation while covering vast areas. We acquired SAR images over four locations in central Florida in order to detect possible pre-collapse or slow subsidence surface movements. The data used in this study were acquired by TerraSAR-X and COSMO-SkyMed satellites with pixel resolutions ranging between 25cm and 2m. To date, we have obtained four datasets, each of 25-30 acquisitions, covering a period of roughly one year over a total of roughly 2200 km2. We also installed two corner reflectors over a subsiding sinkhole located in an open vegetated area, to provide strong scattering and improve coherence over that particular location. We generate PS time series for each of the four datasets. Preliminary results show localized deformation at several houses and commercial buildings in several locations. Deforming areas vary in size from approximately 10mx20m of a single house to 60mx60m for a commercial building. On site ground penetrating radar surveys will be performed in these areas to verify their relationship to possible sinkhole activities. Our results also confirm that the corner reflectors improved PS detection over low coherence areas.

Dissolution of Nickel Ferrite in Aqueous Solutions Containing Oxalic Acid and Ferrous Salts.

PubMed

Figueroa, Carlos A.; Sileo, Elsa E.; Morando, Pedro J.; Blesa, Miguel A.

2000-05-15

The dissolution of nickel ferrite in oxalic acid and in ferrous oxalate-oxalic acid aqueous solution was studied. Nickel ferrite was synthesized by thermal decomposition of a mixed tartrate; the particles were shown to be coated with a thin ferric oxide layer. Dissolution takes place in two stages, the first one corresponding to the dissolution of the ferric oxide outer layer and the second one being the dissolution of Ni(1.06)Fe(1.96)O(4). The kinetics of dissolution during this first stage is typical of ferric oxides: in oxalic acid, both a ligand-assisted and a redox mechanism operates, whereas in the presence of ferrous ions, redox catalysis leads to a faster dissolution. The rate dependence on both oxalic acid and on ferrous ion is described by the Langmuir-Hinshelwood equation; the best fitting corresponds to K(1)(ads)=25.6 mol(-1) dm(-3) and k(1)(max)=9.17x10(-7) mol m(-2) s(-1) and K(2)(ads)=37.1x10(3) mol(-1) dm(-3) and k(2)(max)=62.3x10(-7) mol m(-2) s(-1), respectively. In the second stage, Langmuir-Hinshelwood kinetics also describes the dissolution of iron and nickel from nickel ferrite, with K(1)(ads)=20.8 mol(-1) dm(3) and K(2)(ads)=1.16x10(5) mol(-1) dm(3). For iron, k(1)(max)=1.02x10(-7) mol of Fe m(-2) s(-1) and k(2)(max)=2.38x10(-7) mol of Fe m(-2) s(-1); for nickel, the rate constants k(1)(max) and k(2)(max) are 2.4 and 1.79 times smaller, respectively. The factor 1.79 agrees nicely with the stoichiometric ratio, whereas the factor 2.4 implies the accumulation of some nickel in the residual particles. The rate of nickel dissolution in oxalic acid is higher than that in bunsenite by a factor of 8, whereas hematite is more reactive by a factor of 9 (in the absence of Fe(II)) and 27 (in the presence of Fe (II)). It may be concluded that oxalic acid operates to dissolve iron, and the ensuing disruption of the solid framework accelerates the release of nickel. Copyright 2000 Academic Press.

The sinkhole of Schmalkalden, Germany - Imaging of near-surface subrosion structures and faults

NASA Astrophysics Data System (ADS)

Wadas, Sonja H.; Tschache, Saskia; Polom, Ulrich; Krawczyk, Charlotte M.

2017-04-01

In November 2010 a sinkhole of 30 m diameter and 20 m depth opened in a residential area in the village Schmalkalden, Germany, which fortunately led to damage of buildings and property only. The collapse was caused by leaching of soluble rocks in the subsurface, called subrosion. For an improved understanding of the processes leading to subrosion and sinkhole development a detailed characterization of the subsurface structures and elastic parameters is required. We used shear wave reflection seismic, which has proven to be a suitable method for high-resolution imaging of the near-surface. The village Schmalkalden is located in southern Thuringia in Germany. Since the Upper Cretaceous the area is dominated by fault tectonics, fractures and joints, which increase the rock permeability. The circulating groundwater leaches the Permian saline deposits in the subsurface and forms upward migrating cavities, which can develop into sinkholes, if the overburden collapses. In the direct vicinity of the backfilled sinkhole, five 2-D shear wave reflection seismic profiles with total length of ca. 900 m and a zero-offset VSP down to 150 m depth were acquired. For the surface profiles a 120-channel landstreamer attached with horizontal geophones and an electrodynamic micro-vibrator, exciting horizontally polarized shear waves, were used. For the VSP survey an oriented borehole probe equipped with a 3C-geophone and electrodynamic and hydraulic vibrators, exciting compression- and shear waves, were utilized. The seismic sections show high-resolution images from the surface to ca. 100 m depth. They display heterogeneous structures as indicated by strong vertical and lateral variations of the reflectors. In the near-surface, depressions are visible and zones of low seismic velocities < 180 m/s show increased attenuation of the seismic wave field. These are probably the result of the fractured underground, due to fault tectonics and the ongoing subrosion. The unstable zones are

New Prospecting Standarts and Its Comparison with International Regulations in Sinkhole and Cave Investigations

NASA Astrophysics Data System (ADS)

Karabulut, S.; Cengiz Cinku, M.; Tezel, O.

2016-12-01

The aim of this study is to investigate the prospecting standarts in sinkhole and cave characterization comparing it with the present standarts given by the American Society for Testing and Materials (ASTM) and the British Standart (BSI). Cave and sinkholes which are important geological occurences could cause hazard and collapse of the ground where residental areas could be under risk. The depth of sinkholes could reach up to hundreds of meters and their width to tens of meters. Most caves which are under conserve and characterized as a natural protected area, a non-destructive investigation is required which is only undertaken by geophysical applications. Two different type of standarts are given in the literature to investigate this kind of geological occurences. The first is the ASTM (1999) standart which offers to use Gravity/Microgravity, Ground Penetrating Radar (GPR) and Electromagnetic, while the BSI standart (1999) depends on the initial application of GPR, Electromagnetic, Electrical Resistivity and Crosshole Seismic. In Turkey however, there are limited studies in cave/sinkhole detection and no standartization in prospecting is presented. For this purpose, we applied a geophysical study in the Yarımburgaz cave, Istanbul/Turkey. In the scope of this study, Microgravity, Electric Tomography, Tomography of Seismic Refraction and Surface Wave Analysis, GPR and Microtremor methods are applied on four different profiles. It has been shown that the outputs of the methods differ as a result of the climatic conditions, properties of the geological environment and the depth/size/shape of the sinkhole/cave. Besides this, the area of application which is either inside the city center, steep valley or on the sea/streamside show also discrepancy in the order of preference of the geophysical application methods when considering the anomalies on different mediums. The results obtained from GPR are deep in relation with the thickness of the clayey unit, the water

Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for preformulation.

PubMed

Alsenz, Jochem; Haenel, Elisabeth; Anedda, Aline; Du Castel, Pauline; Cirelli, Giorgio

2016-05-25

This study describes a novel Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for measuring disk intrinsic dissolution rates (DIDR). In MINDISS, compacted mini disks of drugs (2-5mg/disk) are prepared in custom made holders with a surface area of 3mm(2). Disks are immersed, pellet side down, into 0.35ml of appropriate dissolution media per well in 96-well microtiter plates, media are stirred and disk-holders are transferred to new wells after defined periods of time. After filtration, drug concentration in dissolution media is quantified by Ultra Performance Liquid Chromatography (UPLC) and solid state property of the disk is characterized by Raman spectroscopy. MINDISS was identified as an easy-to-use tool for rapid, parallel determination of DIDR of compounds that requires only small amounts of compound and of dissolution medium. Results obtained with marketed drugs in MINDISS correlate well with large scale DIDR methods and indicate that MINDISS can be used for (1) rank-ordering of compounds by intrinsic dissolution in late phase discovery and early development, (2) comparison of polymorphic forms and salts, (3) screening and selection of appropriate dissolution media, and (4) characterization of the intestinal release behavior of compounds along the gastro intestinal tract by changing biorelevant media during experiments. Copyright © 2015 Elsevier B.V. All rights reserved.

Detection of sinkholes or anomalies using full seismic wave fields.

DOT National Transportation Integrated Search

2013-04-01

This research presents an application of two-dimensional (2-D) time-domain waveform tomography for detection of embedded sinkholes and anomalies. The measured seismic surface wave fields were inverted using a full waveform inversion (FWI) technique, ...

Guidelines for sinkhole and subsidence rehabilitation based on generic geological models of a dolomite environment on the East Rand, South Africa

NASA Astrophysics Data System (ADS)

Kleinhans, Ilse; Van Rooy, J. Louis

2016-05-01

A sound understanding of the various factors influencing and associated with the formation of sinkholes or subsidences on dolomite land is essential for the selection of appropriate rehabilitation methods. The investigation and rehabilitation of numerous sinkholes and subsidences located on dolomite in the East Rand of South Africa, created an opportunity to develop a broad based understanding of different karst environments, their susceptibility to sinkhole and subsidence formation and best practice rehabilitation methods. This paper is based on the guidelines developed whereby the geological model of the sinkhole or subsidence is used to recommend an appropriate rehabilitation method. Nine typical geological models with recommended rehabilitation methods are presented in this paper.

A Multi-Sensor Approach to Documenting a Large Collapse Sinkhole in West-Central Florida

NASA Astrophysics Data System (ADS)

Collins, L. D.; Kiflu, H. G.; Robinson, T.; Doering, T.; Eilers, D.; Rodgers, M.; Kruse, S.; Landry, S.; Braunmiller, J.; Speed, G.; Gonzalez, J.; McKenzie, R.

2017-12-01

The Saxon Lake sinkhole collapse of July 14, 2017 in Land O Lakes, Florida, caused the destruction of two homes and the evacuation of nine additional residences. The sinkhole is slightly oval with dimensions of approximately 51 meters east-west and 42 meters north-south, and it is reportedly 15 meters deep. This is presumably the largest sinkhole to form in Pasco County during the last 30 years. The surface collapse happened rapidly and continued over three days, with slumping and erosion increasing the size. The site is located near two natural lakes in a housing development from the late 1960s. This occurrence is within an area of well-developed karst, with a number of natural lakes. We present preliminary analysis of the sequence of deformation, sinkhole geometry, surrounding subsurface structures, and seismic activity. Data are assembled from terrestrial and aerial LiDAR, UAS survey and PhoDAR modeling, aerial imagery, ground penetrating radar, lake-bottom profiling, and seismic monitoring. Additionally, multi-sensor data were brought together in a Geographic Information Systems (GIS) and included an analysis of georeferenced historic imagery and maps. These spatial data indicate historic land use change and development alterations that included lake shore reconfiguration, canal construction, and connection of lake water systems in the area of impact. Three subsidence reports from the 1980s are also recorded within 500 meters of the collapse.

Suitability of Palestine salt dome, Anderson Co. , Texas for disposal of high-level radioactive waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patchick, P.F.

1980-01-01

The suitability of Palestine salt dome, in Anderson County, Texas, is in serious doubt for a repository to isolate high-level nuclear waste because of abandoned salt brining operations. The random geographic and spatial occurrence of 15 collapse sinks over the dome may prevent safe construction of the necessary surface installations for a repository. The dissolution of salt between the caprock and dome, from at least 15 brine wells up to 500 feet deep, may permit increased rates of salt dissolution long into future geologic time. The subsurface dissolution is occurring at a rate difficult, if not impossible, to assess ormore » to calculate. It cannot be shown that this dissolution rate is insignificant to the integrity of a future repository or to ancillary features. The most recent significant collapse was 36 feet in diameter and took place in 1972. The other collapses ranged from 27 to 105 feet in diameter and from 1.5 to more than 15 feet in depth. ONWI recommends that this dome be removed from consideration as a candidate site.« less

Geomicrobiology and hopanoid content of sulfidic subsurface vent biofilms, Little Salt Spring, Florida

NASA Astrophysics Data System (ADS)

Yang, E.; Schaperdoth, I.; Albrecht, H.; Freeman, K. H.; Macalady, J. L.

2008-12-01

Sulfide-rich, oxygen-poor environments are widespread in the subsurface and were prevalent at the earth's surface during critical intervals in the geologic past. Modern microbial communities in sulfidic niches have the potential to shed light on the biogeochemistry and biosignatures of anoxia and euxinia in earth history. Caves and sinkholes provide rare windows into microbially-dominated, sulfidic subsurface environments that are otherwise difficult and expensive to access. Little Salt Spring (Sarasota County, Florida) is a cover-collapse sinkhole lake with oxic surface water and anoxic, sulfidic bottom water (Alvarez Zarikian 2005). The site is famous for excellent preservation of human and animal archaeological remains (Clausen 1979), and its microbiology has never been investigated. Abundant white biofilms develop seasonally at a warm vent that feeds into the anoxic bottom water at 73 m depth below the water surface. The biofilms are of interest both as potential sources of biomarker compounds and because of their likely role in sulfuric acid production and limestone dissolution (speleogenesis). Biofilm samples were collected by expert science divers and investigated using microscopy, nucleic acid, and lipid analytical methods. Microscopy of the live biofilm revealed clusters of microbial filaments with holdfasts and dendritic, sulfur-rich colonial structures similar to those described in the 1960s for Thiobacterium, a sulfur-oxidizing genus with undetermined phylogeny. A 16S rDNA library constructed from the biofilm was split into three main phylotypes, with multiple clones representing (1) a Betaproteobacterial clade with no cultivated representatives, (2) filamentous Epsilonproteobacteria, and (3) a major bacterial lineage without named isolates (OP11/OD2). A full cycle rRNA approach is currently underway to link 16S rDNA phylotypes with specific populations in the biofilm. We confirmed using fluorescence in situ hybridization (FISH) that abundant

Natural and human-induced sinkholes in gypsum terrain and associated environmental problems in NE Spain

NASA Astrophysics Data System (ADS)

Benito, G.; Del Campo, P. Pérez; Gutiérrez-Elorza, M.; Sancho, C.

1995-04-01

The central Ebro Basin comprises thick evaporite materials whose high solubility produces typically karstic landforms. The sinkhole morphology developed in the overlying alluvium has been studied using gravimetry and ground-penetrating radar (GPR) on stream terraces, as well as analyzing the evolution of sinkhole morphologies observed in aerial photographs taken in 1928, 1957, and 1985. The sinkhole morphologies give some idea of possible subsurface processes as well as an indication of the final mechanisms involve in sinkhole development. On stream terraces and cover pediments the most commonly encountered dolines are bowl-shaped in their morphology with both diffuse and scarped edges. In contrast, dolines developed in the gypsiferous silt infilled valleys have a funnel and well-shaped morphology. The diffuse-edged bowl-shaped dolines are developed through the progressive subsidence of the alluvial cover, due to washing down of alluvial particles through small voids and cracks into deeper subsurface caves, resulting in a decrease alluvial density. Future compaction of the alluvial cover will produce surface subsidences. This type of dolines are associated with negative gravity anomalies. In contrast, the scarped-edge dolines are formed by the sudden collapse of a cavity roof. The cavities and cracks formed in the gypsum karst may migrate to the surface through the alluvial deposits by piping, and they may subsequently collapse. In this instance, the cavities can be detected by both gravity and GPR anomalies where the voids are not deeper than 4 5 m from the surface. These processes forming sinkholes can be enhanced by man-induced changes in the groundwater hydrologic regime by both inflows, due to irrigation, ditch losses, or pipe leakages, and by outflows from pumping activities.

Oral sustained-release suspension based on a lauryl sulfate salt/complex.

PubMed

Kasashima, Yuuki; Uchida, Shinya; Yoshihara, Keiichi; Yasuji, Takehiko; Sako, Kazuhiro; Namiki, Noriyuki

2016-12-30

The objective of this study was to evaluate the feasibility of lauryl sulfate (LS) salt/complex as a novel carrier in oral sustained-release suspensions. Mirabegron, which has a pH-dependent solubility, was selected as the model drug. Sodium lauryl sulfate (SLS) was bound to mirabegron in a stoichiometric manner to form an LS salt/complex. LS salt/complex formulation significantly reduced the solubility of mirabegron and helped mirabegron achieve sustained-release over a wide range of pH conditions. Microparticles containing the LS salt/complex were prepared by spray drying with the aqueous dispersion of ethylcellulose (Aquacoat ® ECD). The diameter of the microparticles was less than 200μm, which will help avoid a gritty taste. In vitro results indicated the microparticles had slower dissolution profiles than the LS salt/complex. The dissolution rate could be controlled flexibly by changing the amount of Aquacoat ® ECD. The microparticle suspension retained the desired sustained-release property and dissolution profile after being stored for 30days at 40°C. In addition, the suspension displayed sustained-release behavior in dogs without a pronounced C max peak, which will help prevent side effects. These results suggest that microparticles containing LS salt/complex may be useful as a novel sustained-release suspension for oral delivery. Copyright © 2016 Elsevier B.V. All rights reserved.

DEVELOPMENT OF AN INSOLUBLE SALT SIMULANT TO SUPPORT ENHANCED CHEMICAL CLEANING TESTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eibling, R

The closure process for high level waste tanks at the Savannah River Site will require dissolution of the crystallized salts that are currently stored in many of the tanks. The insoluble residue from salt dissolution is planned to be removed by an Enhanced Chemical Cleaning (ECC) process. Development of a chemical cleaning process requires an insoluble salt simulant to support evaluation tests of different cleaning methods. The Process Science and Engineering section of SRNL has been asked to develop an insoluble salt simulant for use in testing potential ECC processes (HLE-TTR-2007-017). An insoluble salt simulant has been developed based uponmore » the residues from salt dissolution of saltcake core samples from Tank 28F. The simulant was developed for use in testing SRS waste tank chemical cleaning methods. Based on the results of the simulant development process, the following observations were developed: (1) A composition based on the presence of 10.35 grams oxalate and 4.68 grams carbonate per 100 grams solids produces a sufficiently insoluble solids simulant. (2) Aluminum observed in the solids remaining from actual waste salt dissolution tests is probably precipitated from sodium aluminate due to the low hydroxide content of the saltcake. (3) In-situ generation of aluminum hydroxide (by use of aluminate as the Al source) appears to trap additional salts in the simulant in a manner similar to that expected for actual waste samples. (4) Alternative compositions are possible with higher oxalate levels and lower carbonate levels. (5) The maximum oxalate level is limited by the required Na content of the insoluble solids. (6) Periodic mixing may help to limit crystal growth in this type of salt simulant. (7) Long term storage of an insoluble salt simulant is likely to produce a material that can not be easily removed from the storage container. Production of a relatively fresh simulant is best if pumping the simulant is necessary for testing purposes. The

Geodetic monitoring of subrosion-induced subsidence processes in urban areas

NASA Astrophysics Data System (ADS)

Kersten, Tobias; Kobe, Martin; Gabriel, Gerald; Timmen, Ludger; Schön, Steffen; Vogel, Detlef

2017-03-01

The research project SIMULTAN applies an advanced combination of geophysical, geodetic, and modelling techniques to gain a better understanding of the evolution and characteristics of sinkholes. Sinkholes are inherently related to surface deformation and, thus, of increasing societal relevance, especially in dense populated urban areas. One work package of SIMULTAN investigates an integrated approach to monitor sinkhole-related mass translations and surface deformations induced by salt dissolution. Datasets from identical and adjacent points are used for a consistent combination of geodetic and geophysical techniques. Monitoring networks are established in Hamburg and Bad Frankenhausen (Thuringia). Levelling surveys indicate subsidence rates of about 4-5 mm per year in the main subsidence areas of Bad Frankenhausen with a local maximum of 10 mm per year around the leaning church tower. Here, the concept of combining geodetic and gravimetric techniques to monitor and characterise geological processes on and below the Earth's surface is exemplary discussed for the focus area Bad Frankenhausen. For the different methods (levelling, GNSS, relative/absolute gravimetry) stable network results at identical points are obtained by the first campaigns, i.e., the results are generally in agreement.

Benthic Bacterial Diversity in Submerged Sinkhole Ecosystems▿ †

PubMed Central

Nold, Stephen C.; Pangborn, Joseph B.; Zajack, Heidi A.; Kendall, Scott T.; Rediske, Richard R.; Biddanda, Bopaiah A.

2010-01-01

Physicochemical characterization, automated ribosomal intergenic spacer analysis (ARISA) community profiling, and 16S rRNA gene sequencing approaches were used to study bacterial communities inhabiting submerged Lake Huron sinkholes inundated with hypoxic, sulfate-rich groundwater. Photosynthetic cyanobacterial mats on the sediment surface were dominated by Phormidium autumnale, while deeper, organically rich sediments contained diverse and active bacterial communities. PMID:19880643

Evidence of spring formation and subrosion-induced sinkhole development at Ghor Al-Haditha, Jordan, from repeated close-range photogrammetry

NASA Astrophysics Data System (ADS)

Al-Halbouni, Djamil; Eoghan, P. Holohan; Leila, Saberi; Hussam, Alrshdan; Thomas, Walter; Ali, Sawarieh; Torsten, Dahm

2016-04-01

The widespread development of sinkholes and land subsidence poses a major geological hazard to infrastructure, local population, agriculture and industry in the Dead Sea area. For assessment of the key physical factors in this development, repeated photogrammetric and field surveys at Ghor Al-Haditha in Jordan have been undertaken. Recent results provide evidence for subrosion based on strong periodic water flows, as the basic underlying physical process of such land subsidence phenomena. From combined Helikite- and Quatrocopter-based photogrammetric surveys, high resolution Digital Surface Models from October 2014 and October 2015 are compared. Change detection reveals: (1) active subsidence in a hundred metre-scale depression zone, (2) a highly-dynamic spring and canyon system connected with recent sinkhole collapses and (3) the rapid formation of new sinkholes both in alluvium and mud cover sediments. The formation of new sinkholes has been documented locally by means of aerial and field observations during a storm with strong rainfall. A new artesian spring formed in the former Dead Sea bed (mud-flat) at this event. The alluvial sediment load of the stream, a periodic location change of the spring and a connected uphill sinkhole cluster formation provide strong evidence for subrosion of weak material with subsequent underground void collapse. Additionally a documented lake and its' subsequent drainage forming a new canyon reveals the local penetration of the aquiclude behavior of the mud-flat in the major depression area, which can be explained by an under-saturated groundwater flow at a strong hydrostatic gradient. Furthermore an enlargement of the investigated area in the 2015 survey indicates a continuation of subsidence and sinkhole activity towards the North. It reveals several points of emanation of water streams in the mud-flat beneath the alluvial cover and vegetation as an indicator of relatively fresh groundwater inflow. This repeated photogrammetry

Monitoring the snowpack volume in a sinkhole on Mount Lebanon using time lapse Photogrammetry

NASA Astrophysics Data System (ADS)

Abou Chakra, C.; Gascoin, S.; Somma, J.; Drapeau, L.; Fanise, P.

2017-12-01

Lebanon is one of the richest country in the Middle East for water resources, thanks to its mountain ranges that trigger precipitation from the moist air masses coming from the Mediterranean Sea. Snowpack acts as natural water storage in winter and supply fresh water during spring and summer. Yet, Lebanon is facing a serious water scarcity problem due to: i) decreasing amount of precipitation and climate change; ii) major growth of population of original residence and large number of refugees during regional wars. Therefore, continuous and systematic monitoring of the Lebanese water resources is becoming crucial. The Mount Lebanon is made of karstic depressions named "sinkholes". It is important to monitor the snowmelt process inside these sinkholes because of their key role as "containers" of seasonal snow. By isolating the snowpack from sun radiation and wind, they slow down the natural melting process and sublimation, thus delaying as well the low water flow period. An observatory is set up to monitor the snowpack evolution in a pilot sinkhole located in Mount Lebanon. The system uses three time-lapse cameras and structure-from-motion principles to reconstruct the snow volume within the sinkhole. The approach is validated by standard topographic surveys. The results indicate that snow depth can be retrieved with an accuracy between 20 and 60 cm (residuals standard deviation) and a low bias of 50 cm after coregistration of the digital elevation models.

Formation of regolith-collapse sinkholes in southern Illinois: Interpretation and identification of associated buried cavities

USGS Publications Warehouse

Panno, S.V.; Wiebel, C.P.; Heigold, P.C.; Reed, P.C.

1994-01-01

Three regolith-collapse sinkholes formed near the Dongola Unit School and the Pentecostal Church in the southern Illinois village of Dongola (Union County) during the spring of 1993. The sinkholes appeared over a three-month period that coincided with development of a new municipal well. The new well was drilled through clay-rich, valley-fill sediment into karstified limestone bedrock. The piezometric surface of the limestone aquifer is above land surface, indicating the presence of an upward hydraulic gradient in the valley and that the valley fill is acting as a confining unit. Pumping during development of the well lowered the piezometric surface of the limestone aquifer to an elevation below the base of the valley fill. It is hypothesized that drainage of water from the sediments, the resulting loss of hydrostatic pressure and buoyant force in overlying sediments, increased intergranular pressure, and the initiation of groundwater flow toward the well resulted in rapid sediment transport, subsurface erosion, and collapse of the valley-fill sediment. The sinkholes follow an approximately east-west alignment, which is consistent with one of the two dominant alignments of passages of nearby joint-controlled caves. A constant electrode-separation resistivity survey of the school playground was conducted to locate areas that might contain incipient sinkholes. The survey revealed a positive resistivity anomaly trending N75E in the southern part of the study area. The anomaly is linear, between 5 and 10 m wide, and its trend either intersects or is immediately adjacent to the three sinkholes. The anomaly is interpreted to be a series of pumping-induced cavities in the valley-fill sediments that formed over a preexisting crevice in the karstified bedrock limestone. ?? 1994 Springer-Verlag.

Using lidar data to analyse sinkhole characteristics relevant for understory vegetation under forest cover-case study of a high karst area in the dinaric mountains.

PubMed

Kobal, Milan; Bertoncelj, Irena; Pirotti, Francesco; Dakskobler, Igor; Kutnar, Lado

2015-01-01

In this article, we investigate the potential for detection and characterization of sinkholes under dense forest cover by using airborne laser scanning data. Laser pulse returns from the ground provide important data for the estimation of digital elevation model (DEM), which can be used for further processing. The main objectives of this study were to map and determine the geomorphometric characteristics of a large number of sinkholes and to investigate the correlations between geomorphology and vegetation in areas with such characteristics. The selected study area has very low anthropogenic influences and is particularly suitable for studying undisturbed karst sinkholes. The information extracted from this study regarding the shapes and depths of sinkholes show significant directionality for both orientation of sinkholes and their distribution over the area. Furthermore, significant differences in vegetation diversity and composition occur inside and outside the sinkholes, which indicates their presence has important ecological impacts.

Using Lidar Data to Analyse Sinkhole Characteristics Relevant for Understory Vegetation under Forest Cover—Case Study of a High Karst Area in the Dinaric Mountains

PubMed Central

Kobal, Milan; Bertoncelj, Irena; Pirotti, Francesco; Dakskobler, Igor; Kutnar, Lado

2015-01-01

In this article, we investigate the potential for detection and characterization of sinkholes under dense forest cover by using airborne laser scanning data. Laser pulse returns from the ground provide important data for the estimation of digital elevation model (DEM), which can be used for further processing. The main objectives of this study were to map and determine the geomorphometric characteristics of a large number of sinkholes and to investigate the correlations between geomorphology and vegetation in areas with such characteristics. The selected study area has very low anthropogenic influences and is particularly suitable for studying undisturbed karst sinkholes. The information extracted from this study regarding the shapes and depths of sinkholes show significant directionality for both orientation of sinkholes and their distribution over the area. Furthermore, significant differences in vegetation diversity and composition occur inside and outside the sinkholes, which indicates their presence has important ecological impacts. PMID:25793871

Repair of the Czar Shaft sinkhole

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deatherage, J.D.; Starkey, J.; Gustavson, N.

1996-12-31

After a Portion of the Queen Mine parking lot collapsed into a sinkhole, an engineering study was conducted to confirm that the cause of the damage was settlement into the Czar Shaft in Bisbee, Arizona. Historical records were researched to describe and locate the original shaft, and a seismic refraction survey was performed to define the foundation conditions within and around the shaft. Recommended mitigation measures were developed to repair the parking lot. Mitigation included design and construction of a flexible geosynthetic cap and telltale settlement monitoring system.

Coordinated motility of cyanobacteria favor mat formation, photosynthesis and carbon burial in low-oxygen, high-sulfur shallow sinkholes of Lake Huron; whereas deep-water aphotic sinkholes are analogs of deep-sea seep and vent ecosystems

NASA Astrophysics Data System (ADS)

Biddanda, B. A.; McMillan, A. C.; Long, S. A.; Snider, M. J.; Weinke, A. D.; Dick, G.; Ruberg, S. A.

2016-02-01

Microbial life in submerged sinkhole ecosystems of the Laurentian Great Lakes is relatively understudied in comparison to seeps and vents of the deep-sea. We studied the filamentous benthic mat-forming cyanobacteria consisting primarily of Oscillatoria-like cells growing under low-light, low-oxygen and high-sulfur conditions in Lake Huron's submerged sinkholes using in situ observations, in vitro measurements and time-lapse microscopy. Gliding movement of the cyanobacterial trichomes revealed individual as well as group-coordinated motility. When placed in a petri dish and dispersed in ground water from the sinkhole, filaments re-aggregated into defined colonies within minutes. Measured speed of individual filaments ranged from 50 µm minute-1 or 15 body lengths minute-1 to 215 µm minute-1 or 70 body lengths minute-1 - rates that are rapid relative to non-flagellated/ciliated microbes. Filaments exhibited precise and coordinated positive phototaxis towards pinpoints of light and congregated under the light of foil cutouts. Such light-responsive clusters showed an increase in photosynthetic yield - suggesting phototactic motility aids in light acquisition as well as photosynthesis. Pebbles and pieces of broken shells placed upon the mat in intact sediemnt cores were quickly covered by vertically motile filaments within hours and became fully buried in the anoxic sediments over 3-4 diurnal cycles - likely facilitating the preservation of falling plankton debris. Coordinated horizontal and vertical filament motility optimize mat cohesion and dynamics, photosynthetic efficiency and sedimentary carbon burial in modern-day sinkhole habitats where life operates across sharp redox gradients. Analogous cyanobacterial motility in the shallow seas during Earth's early history, may have played a key role in the oxygenation of the planet by optimizing photosynthesis while favoring carbon burial. We are now eagerly mapping and exploring life in deep-water aphotic sinkholes of

Interactions between a poorly soluble cationic drug and sodium dodecyl sulfate in dissolution medium and their impact on in vitro dissolution behavior.

PubMed

Huang, Zongyun; Parikh, Shuchi; Fish, William P

2018-01-15

In the pharmaceutical industry, in vitro dissolution testing ofsolid oral dosage forms is a very important tool for drug development and quality control. However, ion-pairing interaction between the ionic drugand surfactants in dissolution medium often occurs, resulting in inconsistent and incomplete drug release. The aim of this study is toevaluate the effects ofsodium dodecyl sulfate (SDS) mediated medium onthe dissolution behaviors of a poorly soluble cationic drug (Drug B). The study was carried out by measuring solubility of Drug B substance and dissolution rate of Drug B product in media containing SDS.Desolubilization of Drug B substance was observed at pH 4.5 in the presence of SDS at concentrations below critical micelle concentration (CMC) which is attributed to the formation of an insoluble di-dodecyl sulfate salt between SDS and Drug B. This ion-pairing effect is less significant with increasing medium pH where Drug B is less ionized and CMC of SDS is lower. In medium at pH 4.5, dissolution of Drug B product was found incomplete with SDS concentration below CMC due to the desolubilization of Drug B substance. In media with SDS level above CMC, the dissolution rate is rather slower with higher inter-vessel variations compared to that obtained in pH 4.5 medium without SDS. The dissolution results demonstrate that the presence of SDS in medium generates unexpected irregular dissolution profiles for Drug B which are attributed to incompatible dissolution medium for this particular drug. Therefore, non-ionic surfactant was selected for Drug B product dissolution method and ion-pairing effect in SDS mediated medium should be evaluated when developing a dissolution method for any poorly soluble cationic drugs. Copyright © 2017 Elsevier B.V. All rights reserved.

Salt tectonics and shallow subseafloor fluid convection: Models of coupled fluid-heat-salt transport

USGS Publications Warehouse

Wilson, A.; Ruppel, C.

2007-01-01

Thermohaline convection associated with salt domes has the potential to drive significant fluid flow and mass and heat transport in continental margins, but previous studies of fluid flow associated with salt structures have focused on continental settings or deep flow systems of importance to petroleum exploration. Motivated by recent geophysical and geochemical observations that suggest a convective pattern to near-seafloor pore fluid flow in the northern Gulf of Mexico (GoMex), we devise numerical models that fully couple thermal and chemical processes to quantify the effects of salt geometry and seafloor relief on fluid flow beneath the seafloor. Steady-state models that ignore halite dissolution demonstrate that seafloor relief plays an important role in the evolution of shallow geothermal convection cells and that salt at depth can contribute a thermal component to this convection. The inclusion of faults causes significant, but highly localized, increases in flow rates at seafloor discharge zones. Transient models that include halite dissolution show the evolution of flow during brine formation from early salt-driven convection to later geothermal convection, characteristics of which are controlled by the interplay of seafloor relief and salt geometry. Predicted flow rates are on the order of a few millimeters per year or less for homogeneous sediments with a permeability of 10−15 m2, comparable to compaction-driven flow rates. Sediment permeabilities likely fall below 10−15 m2 at depth in the GoMex basin, but such thermohaline convection can drive pervasive mass transport across the seafloor, affecting sediment diagenesis in shallow sediments. In more permeable settings, such flow could affect methane hydrate stability, seafloor chemosynthetic communities, and the longevity of fluid seeps.

Towards an integrated approach for characterization of sinkhole hazards in urban environments: the unstable coastal site of Casalabate, Lecce, Italy

NASA Astrophysics Data System (ADS)

Delle Rose, Marco; Leucci, Giovanni

2010-06-01

Sinkholes occur in many areas of the world, especially where carbonate rocks crop out. They are formed due to natural processes or caused by man's activities. In both cases, severe consequences have to be registered on the anthropogenic environment and related infrastructures. Knowledge of both the mechanism of the sinkhole formation and the localization of this subtle geohazard is therefore necessary for planners and decision makers to perform the most appropriate and suitable programs of land use and development. The Apulia region of southern Italy is characterized for most of its extension by carbonate rocks, which makes it one of the most remarkable examples of karst in the Mediterranean basin. The sinkhole formation in Apulia urban areas has recently produced severe damages, especially along its coastal planes, where different types of sinkholes occur. The detection of cavities, that could collapse and create a sinkhole, in an urban environment presents numerous difficulties (buried networks, reworked soils, etc). A methodology has been developed to respond to this need based on the integration of four complementary methods: geological analysis of outcrops and existing borehole descriptions, aerophotogrammetric interpretation of aerial photos, electrical resistivity tomography (ERT) and ground penetrating radar (GPR). The combination of these methods, applied to a test sector in the city of Casalabate, made it possible to locate the principal karstic conduits beneath the study area and identify a zone of high sinkhole geohazard associated with one such feature.

Development of a salt drug with improved solubility: Ethionamide nitrate

NASA Astrophysics Data System (ADS)

Diniz, Luan F.; Carvalho, Paulo S.; de Melo, Cristiane C.; Ellena, Javier

2017-06-01

To avoid drug resistance, an adequate tuberculosis treatment should include not only a first-line drug but also at least one second-line drug such as, for example, Ethionamide (ETH). However, the dissolution rate and oral absorption of ETH is highly limited by its low aqueous solubility. Considering that a salt is in general more soluble than its parent compound, herein we depicted a new supramolecular modification of ETH, an Ethionamide nitrate salt (ETHNO3). This salt is the first ETH structure that has been crystallized with four independent ionic pairs (ETH+NO3-) in the asymmetric unit. In addition to the structural study, the salt formation was also identified on the FT-IR and FT-Raman spectra. The thermal behavior of ETHNO3 was also investigated here together with its solubility profile in three dissolution media (purified water, pH 4.0 and 7.0).

Dissolution of solid lipid extrudates in biorelevant media.

PubMed

Witzleb, R; Müllertz, A; Kanikanti, V-R; Hamann, H-J; Kleinebudde, P

2012-01-17

Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin. Thermoanalytical and dissolution behaviour was investigated directly after extrusion and after 3 and 6 months open storage at 40°C/75% RH. Dissolution studies were conducted in hydrochloric acid (HCl) pH 1.2 with different levels of polysorbate 20 and with a biorelevant medium containing pancreatic lipase, bile salts and phospholipids. Furthermore, the impact of lipid digestion on drug release was studied using in vitro lipolysis. The release of praziquantel from cetyl palmitate and glyceryl monostearate in the biorelevant medium was much faster than in HCl, whereas there was hardly any difference for the other lipids. It was shown that drug release from glyceryl monostearate matrices is driven by both solubilisation and enzymatic degradation of the lipid, whereas dissolution from cetyl palmitate extrudates is dependent only on solubilisation by surfactants in the medium. Moreover, storage influenced the appearance of the extrudate surface and the dissolution rate for all lipids except solid paraffin. Copyright © 2011 Elsevier B.V. All rights reserved.

Engineering geologic conditions at the sinkhole entrance to Logan Cave, Benton County, Arkansas

USGS Publications Warehouse

Schulz, William H.; McKenna, Jonathan P.

2004-01-01

Logan Cave, located in Benton County, Arkansas, is inhabited by several endangered and threatened species. The cave and surrounding area was designated a National Wildlife Refuge under the control of the U.S. Fish and Wildlife Service (USFWS) in 1989. Cave researchers access the cave through a steep-sided sinkhole entrance, which also is one of the two access points used by endangered bats. There is evidence of instability of one of the entrance slopes that has raised concerns that the entrance could close if slope failure was to occur. At the request of USFWS, we performed an engineering geologic investigation of the sinkhole to evaluate stability of this slope, which is comprised of soil, and other mechanisms of sediment transport into the cave entrance. The investigation included engineering geologic mapping, sampling and laboratory testing of subsurface geologic materials, and slope-stability analysis. We found that the sinkhole slope that extends into the entrance of the cave is comprised of sandy and gravelly soil to the depths explored (6.4 meters). This soil likely was deposited as alluvium within a previous, larger sinkhole. Based on properties of the alluvium, geometry of the slope, and results of finite-element slope-stability analyses, we conclude that the slope is marginally stable. Future failures of the slope probably would be relatively thin and small, thus several would be required to completely close the cave entrance. However, sediment is accumulating within the cave entrance due to foot traffic of those accessing the cave, surface-water erosion and transport, and shallow slope failures from the other sinkhole slopes. We conclude that the entrance will be closed by sediment in the future, similar to another entrance that we identified that completely closed in the past. Several measures could be taken to reduce the potential for closure of the cave entrance, including periodic sediment removal, installation of materials that reduce erosion by

Characterization and evaluation of miconazole salts and cocrystals for improved physicochemical properties.

PubMed

Tsutsumi, Shunichirou; Iida, Motoo; Tada, Norio; Kojima, Takashi; Ikeda, Yukihiro; Moriwaki, Toshiya; Higashi, Kenjirou; Moribe, Kunikazu; Yamamoto, Keiji

2011-12-15

Miconazole salts and cocrystals were studied to improve the physicochemical properties of miconazole. Maleate, hemifumarate, and hemisuccinate were prepared and characterized by powder X-ray diffractometry, differential scanning calorimetry, and single crystal X-ray diffractometry. The intrinsic dissolution rate and stability of each miconazole crystal form were compared to those of freebase and nitrate to evaluate the optimal crystal form. Crystal structure analysis indicated that maleate was a salt formed by proton transfer from the acid to the imidazole group of miconazole. Hemifumarate and hemisuccinate were determined to be cocrystals formed by hydrogen bonding between the acids and the base in their crystal lattices. Intrinsic dissolution tests showed that the formation of salts and cocrystals improved the dissolution rate of miconazole. Stability tests of preliminary formulations prepared with each crystal form indicated that maleate and hemifumarate were unstable at 80°C and generated a specific degraded product, i.e., a Michael adduct, between miconazole and the acids. Hemisuccinate had a superior intrinsic dissolution rate and stability, and is thus considered a promising crystal form of miconazole. Copyright © 2011 Elsevier B.V. All rights reserved.

Effect of an offshore sinkhole perforation in a coastal confined aquifer on submarine groundwater discharge

USGS Publications Warehouse

Fratesi, S.E.; Leonard, V.; Sanford, W.E.

2007-01-01

In order to explore submarine groundwater discharge in the vicinity of karst features that penetrate the confining layer of an offshore, partially confined aquifer, we constructed a three-dimensional groundwater model using the SUTRA (Saturated-Unsaturated TRAnsport) variable-density groundwater flow model. We ran a parameter sensitivity analysis, testing the effects of recharge rates, permeabilities of the aquifer and confining layer, and thickness of the confining layer. In all simulations, less than 20% of the freshwater recharge for the entire model exits through the sinkhole. Recirculated seawater usually accounts for 10-30% of the total outflow from the model. Often, the sinkhole lies seaward of the transition zone and acts as a recharge feature for recirculating seawater. The permeability ratio between aquifer and confining layer influences the configuration of the freshwater wedge the most; as confining layer permeability decreases, the wedge lengthens and the fraction of total discharge exiting through the sinkhole increases. Copyright ?? 2007 IAHS Press.

Land subsidence caused by dissolution of salt near four oil and gas wells in central Kansas

USGS Publications Warehouse

Fader, Stuart Wesley

1975-01-01

Collapse of the overlying strata into voids caused by dissolution of salt is the apparent cause of progressive land subsidence at the sites of several oil wells that were drilled through the salt beds of the Wellington Formation in Kansas. The purpose of this investigation was to determine if data from four sites, shown in figure 1, substantiate the hypothesis that corroded, broken, or improperly sealed casing permitted relatively fresh water from the shallow aquifers to circulate within the salt zone and that the resulting brine solution leaked downward into permeable zones that would accept the fluid under hydrostatic pressure.Strata similar to those penetrated by wells at the four sites (shown in tables 1 and 2) underlie much of central Kansas. Many thousands of oil and gas wells have been drilled through the salt beds, but land subsidence has been reported at few of the sites. Reported sites are near highways, and two well-documented instances of subsidence involve the stability of highway right-of-way. Because many wells have been drilled in remote areas, similar occurrences may remain unreported. The scope of this investigation is limited to the compilation, analysis and interpretation of the available data from four sites shown in figure 1, and the mention of a fifth site.The photograph (fig. 2) shows a deteriorated casing pulled from a well located between Sites 3 and 4 in western Rice County. The casing consists of inner and outer pipes with the annular space between filled with cement. The almost complete failure of the outer pipe is evident. The casing is believed to be from the well in the concrete pit that is in the lower right of the photograph. The pond in the background is a sink that has developed near the well; detailed historical data, however, were unavailable for further study of this site.The investigation was requested by the Energy Research and Develop-ment Administration (formerly U.S. Atomic Energy Commission) as part of a study of bedded

The effect of electrolytes on dolomite dissolution: nanoscale observations using in situ Atomic Force Microscopy

NASA Astrophysics Data System (ADS)

Urosevic, Maja; Ruiz-Agudo, Encarnacion; Putnis, Christine V.; Cardell, Carolina; Rodriguez-Navarro, Carlos; Putnis, Andrew

2010-05-01

Dissolution of carbonate minerals is one of the main chemical reactions occurring at shallow levels in the crust of the Earth and has a paramount importance for a wide range of geological and biological processes. Calcite (CaCO3), and to a lesser extent dolomite (CaMg(CO3)2), are the major carbonate minerals in sedimentary rocks and building stone materials. The dissolution of calcite has been thoroughly investigated over a range of conditions and solution compositions. In contrast, dolomite dissolution studies have been traditionally hampered by its low reaction rates compared to calcite and its poorly constrained relationship between cation ordering and reactivity (Morse and Arvidson, 2002). Yet important questions like the so-called 'dolomite problem' (e.g. Higgins and Hu, 2005) remain unresolved and more experimental work is needed in order to understand the role of other dissolved species, such as soluble salts, on the kinetics and mechanism of dolomite dissolution and precipitation. We have explored the effect of different electrolytes on the dissolution rate of dolomite by using in situ Atomic Force Microcopy (AFM). Experiments were carried out by passing alkali halide, nitrate and sulfate salt solutions (NaCl, KCl, LiCl, NaI, NaNO3 and Na2SO4) with different ionic strengths (IS = 10-3, 10-2 and 10-1) over dolomite {1014} cleavage surfaces. We show that all electrolytes tested enhance dolomite dissolution. Moreover, the morphology and density of etch pits are controlled by the presence of different ions in solution. The etch pit spreading rate and dolomite dissolution rate depend on both (1) the nature of the electrolyte and (2) the ionic strength. This is in agreement with recent experimental studies on calcite dissolution (Ruiz-Agudo et al., 2010). This study highlights the role of electrolytes in dolomite dissolution and points to a common behavior for carbonate minerals. Our results suggest that soluble salts may play a critical role in the weathering of

"Cleaning" the Surface of Hydroxyapatite Nanorods by a Reaction-Dissolution Approach.

PubMed

Cao, Binrui; Yang, Mingying; Wang, Lin; Xu, Hong; Zhu, Ye; Mao, Chuanbin

2015-10-21

Synthetic nanoparticles are always terminated with coating molecules, which are often cytotoxic and not desired in biomedicine. Here we propose a novel reaction-dissolution approach to remove the cytotoxic coating molecules. A two-component solution is added to the nanoparticle solution; one component reacts with the coating molecules to form a salt whereas another is a solvent for dissolving and thus removing the salt. As a proof of concept, this work uses a NaOH-ethanol solution to remove the cytotoxic linoleic acid molecules coated on the hydroxyapatite nanorods (HAP-NRs). The removal of the coating molecules not only significantly improves the biocompatibility of HAP-NRs but also enables their oriented attachment into tightly-bound superstructures, which mimic the organized HAP crystals in bone and enamel and can promote the osteogenic differentiation of mesenchymal stem cells. Our reaction-dissolution approach can be extended to the surface "cleaning" of other nanomaterials.

Genesis and shape of natural solution cavities within salt deposits

NASA Astrophysics Data System (ADS)

Gechter, Daniel; Huggenberger, Peter; Ackerer, Philippe; Waber, H. Niklaus

2008-11-01

Since the genesis and shape of natural deep-seated cavities within a salt body are insufficiently understood, the current study tries to shed some light on this topic. To this end, freshwater was pumped slowly through a horizontal borehole in rock salt cores. Owing to fast halite dissolution kinetics, high solubility, and slow inflow rate, halite dissolution took place only in the inflow of the rock salt cylinder. The shape of the created cavities is an approximately symmetrical half cone with a horizontal base facing upward. A conceptual model is presented that is inspired by the experimental results and based on theoretical hydraulic-geochemical considerations, as well as on field observations. It proposes that triangular prism or conically shaped cavities develop within salt under confined conditions, where aggressive water flows upward along a fracture/conduit from an insoluble aquifer into the soluble stratum. Such cavity enlargements may cause land subsidence and structure collapse.

Single-station seismic noise measures, microgravity, and 3D electrical tomographies to assess the sinkhole susceptibility: the "Il Piano" area (Elba Island - Italy) case study

NASA Astrophysics Data System (ADS)

Pazzi, Veronica; Di Filippo, Michele; Di Nezza, Maria; Carlà, Tommaso; Bardi, Federica; Marini, Federico; Fontanelli, Katia; Intrieri, Emanuele; Fanti, Riccardo

2017-04-01

Sudden subsurface collapse, cavities, and surface depressions, regardless of shape and origin, as well as doline are currently indicate by means of the term "sinkhole". This phenomenon can be classified according to a large variety of different schemes, depending on the dominant formation processes (soluble rocks karstic processes, acidic groundwater circulation, anthropogenic caves, bedrock poor geomechanical properties), and on the geological scenario behind the development of the phenomenon. Considering that generally sinkholes are densely clustered in "sinkhole prone areas", detection, forecasting, early warning, and effective monitoring are key aspects in sinkhole susceptibility assessment and risk mitigation. Nevertheless, techniques developed specifically for sinkhole detection, forecasting and monitoring are missing, probably because of a general lack of sinkhole risk awareness, and an intrinsic difficulties involved in detecting precursory sinkhole deformations before collapse. In this framework, integration of different indirect/non-invasive geophysical methods is the best practice approach. In this paper we present the results of an integrated geophysical survey at "Il Piano" (Elba Island - Italy), where at least nine sinkholes occurred between 2008 and 2014. 120 single-station seismic noise measures, 17 3D electrical tomographies (min area 140.3 m2, max area 10,188.9 m2; min electrode spacing 2 m, max electrode spacing 5 m), 964 measurement of microgravity spaced in a grid of 6 m to 8 m were carried out at the study area. The most likely origin for these sinkholes was considered related to sediment net erosion from the alluvium, caused by downward water circulation between aquifers. Therefore, the goals of the study were: i) obtaining a suitable geological and hydrogeological model of the area; ii) detecting possible cavities which could evolve in sinkholes, and finally iii) assess the sinkhole susceptibility of the area. Among the results of the

The current status of mapping karst areas and availability of public sinkhole-risk resources in karst terrains of the United States

USGS Publications Warehouse

Kuniansky, Eve L.; Weary, David J.; Kaufmann, James E.

2016-01-01

Subsidence from sinkhole collapse is a common occurrence in areas underlain by water-soluble rocks such as carbonate and evaporite rocks, typical of karst terrain. Almost all 50 States within the United States (excluding Delaware and Rhode Island) have karst areas, with sinkhole damage highest in Florida, Texas, Alabama, Missouri, Kentucky, Tennessee, and Pennsylvania. A conservative estimate of losses to all types of ground subsidence was $125 million per year in 1997. This estimate may now be low, as review of cost reports from the last 15 years indicates that the cost of karst collapses in the United States averages more than $300 million per year. Knowing when a catastrophic event will occur is not possible; however, understanding where such occurrences are likely is possible. The US Geological Survey has developed and maintains national-scale maps of karst areas and areas prone to sinkhole formation. Several States provide additional resources for their citizens; Alabama, Colorado, Florida, Indiana, Iowa, Kentucky, Minnesota, Missouri, Ohio, and Pennsylvania maintain databases of sinkholes or karst features, with Florida, Kentucky, Missouri, and Ohio providing sinkhole reporting mechanisms for the public.

The current status of mapping karst areas and availability of public sinkhole-risk resources in karst terrains of the United States

NASA Astrophysics Data System (ADS)

Kuniansky, Eve L.; Weary, David J.; Kaufmann, James E.

2016-05-01

Subsidence from sinkhole collapse is a common occurrence in areas underlain by water-soluble rocks such as carbonate and evaporite rocks, typical of karst terrain. Almost all 50 States within the United States (excluding Delaware and Rhode Island) have karst areas, with sinkhole damage highest in Florida, Texas, Alabama, Missouri, Kentucky, Tennessee, and Pennsylvania. A conservative estimate of losses to all types of ground subsidence was 125 million per year in 1997. This estimate may now be low, as review of cost reports from the last 15 years indicates that the cost of karst collapses in the United States averages more than 300 million per year. Knowing when a catastrophic event will occur is not possible; however, understanding where such occurrences are likely is possible. The US Geological Survey has developed and maintains national-scale maps of karst areas and areas prone to sinkhole formation. Several States provide additional resources for their citizens; Alabama, Colorado, Florida, Indiana, Iowa, Kentucky, Minnesota, Missouri, Ohio, and Pennsylvania maintain databases of sinkholes or karst features, with Florida, Kentucky, Missouri, and Ohio providing sinkhole reporting mechanisms for the public.

Differing disintegration and dissolution rates, pharmacokinetic profiles and gastrointestinal tolerability of over the counter ibuprofen formulations.

PubMed

Bjarnason, Ingvar; Sancak, Ozgur; Crossley, Anne; Penrose, Andrew; Lanas, Angel

2018-02-01

Formulations of over the counter (OTC) NSAIDs differ substantially, but information is lacking on whether this alters their gastrointestinal profiles. To assess disintegration and dissolution rates and pharmacokinetics of four preparations of OTC ibuprofen and relate these with spontaneously reported gastrointestinal adverse events. Disintegration and dissolution rates of ibuprofen tablets as (a) acid, (b) sodium salt, (c) lysine salt, and (d) as a liquid gelatine capsule were assessed. Pharmacokinetic data gastrointestinal and spontaneously reported adverse events arising from global sales were obtained from files from Reckitt Benckiser. Disintegration at low pH was progressively shorter for the preparations from a-to-d with formation of correspondingly smaller ibuprofen crystals, while dissolution was consistently poor. Dissolution at a neutral pH was least rapid for the liquid gelatine capsule. Pharmacokinetic data showed a shorter t max and a higher C max for preparations b-d as compared with ibuprofen acid. Spontaneously reported abdominal symptoms were rare with the liquid gelatine preparation. The formulations of OTC ibuprofen differ in their disintegration and dissolution properties, pharmacokinetic profiles and apparent gastrointestinal tolerability. Spontaneously reported abdominal symptoms were five times lower with the liquid gelatine capsule as compared with ibuprofen acid despite a 30% increase in C max . © 2017 Royal Pharmaceutical Society.

Jarosite dissolution rates in perchlorate brine

NASA Astrophysics Data System (ADS)

Legett, Carey; Pritchett, Brittany N.; Elwood Madden, Andrew S.; Phillips-Lander, Charity M.; Elwood Madden, Megan E.

2018-02-01

Perchlorate salts and the ferric sulfate mineral jarosite have been detected at multiple locations on Mars by both landed instruments and orbiting spectrometers. Many perchlorate brines have eutectic temperatures <250 K, and may exist as metastable or stable liquids for extended time periods, even under current Mars surface conditions. Therefore, jarosite-bearing rocks and sediments may have been altered by perchlorate brines. Here we measured jarosite dissolution rates in 2 M sodium perchlorate brine as well as dilute water at 298 K to determine the effects of perchlorate anions on jarosite dissolution rates and potential reaction products. We developed a simple method for determining aqueous iron concentrations in high salinity perchlorate solutions using ultraviolet-visible spectrophotometry that eliminates the risk of rapid oxidation reactions during analyses. Jarosite dissolution rates in 2 M perchlorate brine determined by iron release rate (2.87 × 10-12 ±0.85 × 10-12 mol m-2 s-1) were slightly slower than the jarosite dissolution rate measured in ultrapure (18.2 MΩ cm-1) water (5.06 × 10-12 mol m-2 s-1) using identical methods. No additional secondary phases were observed in XRD analyses of the reaction products. The observed decrease in dissolution rate may be due to lower activity of water (ɑH2O = 0.9) in the 2 M NaClO4 brine compared with ultrapure water (ɑH2O = 1). This suggests that the perchlorate anion does not facilitate iron release, unlike chloride anions which accelerated Fe release rates in previously reported jarosite and hematite dissolution experiments. Since dissolution rates are slower in perchlorate-rich solutions, jarosite is expected to persist longer in perchlorate brines than in dilute waters or chloride-rich brines. Therefore, if perchlorate brines dominate aqueous fluids on the surface of Mars, jarosite may remain preserved over extended periods of time, despite active aqueous processes.

Sinkhole susceptibility mapping using the analytical hierarchy process (AHP) and magnitude-frequency relationships: A case study in Hamadan province, Iran

NASA Astrophysics Data System (ADS)

Taheri, Kamal; Gutiérrez, Francisco; Mohseni, Hassan; Raeisi, Ezzat; Taheri, Milad

2015-04-01

Since 1989, an increasing number of sinkhole occurrences have been reported in the Kabudar Ahang and Razan-Qahavand subcatchments (KRQ) of Hamadan province, western Iran. The sinkhole-related subsidence phenomenon poses a significant threat for people and human structures, including sensitive facilities like the Hamadan Power Plant. Groundwater over-exploitation from the thick alluvial cover and the underlying cavernous limestone has been identified as the main factor involved in sinkhole development. A sinkhole susceptibility model was produced in a GIS environment applying the analytical hierarchy process (AHP) approach and considering a selection of eight factors, each categorized into five classes: distance to faults (DF), water level decline (WLD), groundwater exploitation (GE), penetration of deep wells into karst bedrock (PKA), distance to deep wells (DDW), groundwater alkalinity (GA), bedrock lithology (BL), and alluvium thickness (AT). Relative weights were preliminarily assigned to each factor and to their different classes through systematic pairwise comparisons based on expert judgment. The resulting sinkhole susceptibility index (SSI) values were then classified into four susceptibility classes: low, moderate, high and very high susceptibility. Subsequently, the model was refined through a trial and error process involving changes in the relative weights and iterative evaluation of the prediction capability. Independent evaluation of the final model indicates that 55% and 45% of the subsidence events fall within the very high and high, susceptibility zones, respectively. The results of this study show that AHP can be a useful approach for susceptibility assessment if data on the main controlling factors have sufficient accuracy and spatial coverage. The limitations of the model are partly related to the difficulty of gathering data on some important geological factors, due to their hidden nature. The magnitude and frequency relationship constructed

The role of flooding in the occurrence of sinkholes in mantled karst setting, Orléans area (France)

NASA Astrophysics Data System (ADS)

Noury, Gildas; Perrin, Jerome; Luu, Li-Hua; Philippe, Pierre

2017-04-01

The Loire River basin is regularly impacted by sinkholes because of its specific geological context constituted of karstic limestone overlain by soft materials. Intense rainfall and associated flooding that occurred in this area in May and June 2016 triggered the collapse of tens of sinkholes. At least 20 houses, one high-traffic road, one levee of the Loire River and one highway were directly threatened. This event highlights not only the vulnerability of the area, especially in the case of a disastrous flood of the Loire River, but also an unexpected kinetic of the process. Two different types of sinkholes occurred in flooded areas: on the plateau, spectacular drop out of former natural caves is suspected; in the Loire valley, flooding is supposed to have accelerated the suffosion of alluvium by a factor of 10 000 to 20 000. This feedback bring new insights on the process dynamics that is currently being analysed in more details using an innovative internal erosion numerical modeling approach, based on Discrete Element - DEM and Lattice Boltzmann methods - LBM. A better understanding of the sinkhole formation is crucial for adequate risk management, especially in the case of a large flooding event.

Geochemistry and Hydrogeology of Water-Filled Sinkholes at Bitter Lake NWR, Roswell, NM

NASA Astrophysics Data System (ADS)

Premo, Z. E.; Crossey, L. J.

2008-12-01

Bitter Lake NWR in southeast (Roswell) New Mexico is located at the convergence of the Pecos River and the surface discharge region in the Roswell Artesian Basin (shallow alluvial aquifer and carbonate aquifer). The Refuge hosts approximately 50 water-filled sinkholes, which each support a unique and diverse aquatic ecosystem. An initial survey of water chemistries indicates that each sink has a unique chemical identity and neutral to alkaline pH. Sinkholes are filled by one or more artesian springs, groundwater seepage and possible hydrothermal water sources. We present results of water and gas analyses of 10 representative sinkholes, sampled during spring and summer, 2008. Analytical results, including major ions, metals (arsenic, selenium, iron), and gas chemistries are compared with monitoring well data from wells found to the north of the Refuge, along the Pecos River, and to the west, along the Pecos Slope - the regional aquifer recharge area. Well samples representative of regional groundwater provide potential end member perspectives for sources of sinkhole waters. Samples were collected incrementally from the surface to sinkhole floor to profile the limnological structure and to assess chemical variation and mixing through the water column. A sonde was deployed to measure and record physical parameters. Results of the analysis are used to describe the geochemical mixing that is occurring within the sinks. As each sink behaves as an independent unit, those separated by less than 10 meters can have dramatic variability in chemical signature and biological influence. For example, among the 29 sinks sampled during the initital survey, chloride concentrations range from 1.912x10-3 to 1.405 mol/kg; sulfate from 7.204x10-4 to 0.1364 mol/kg; and fluoride from 3.579x10-4 to 3.453x10-3 mol/kg. Along the Pecos Slope, groundwater chloride concentrations increase from less than 1.410x10-3 mol/kg near the major recharge area in the Sacramento Mountains to 0.141 mol

Sinkhole development in Windsor-Detroit solution mines and the role of downward mass transfer in subsidence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nieto, A.S.; Russell, D.G.

1984-01-01

The main portion of this paper deals with the development of three sinkholes of unexpected size and depth in the WindsorDetroit area. The roles of the Sylvania Sandstone - a unit of unique mechanical properties - and of the high in situ horizontal stresses are evaluated. It is proposed that the Sylvania fails under high horizontal loads, converts into sand, flows downward through cracks towards deeper solution-mine caverns, and creates a shallow void that generates the deep sinkholes. Linear-arch theory is used to evaluate subsidence-induced horizontal stress increments. It is concluded that sinkholes are likely to occur in other areasmore » where the Sylvania is close to the surface (less than 200 m) and active subsidence bowls have surface gradients of a few millimeters per meter. The last section contains a brief discussion of the role of downward mass transfer of slurries in surface subsidence with examples from the Midwest.« less

Quantifying monthly to decadal subsidence and assessing collapse potential near the Wink sinkholes, west Texas, using airborne lidar, radar interferometry, and microgravity

NASA Astrophysics Data System (ADS)

Paine, J. G.; Collins, E.; Yang, D.; Andrews, J. R.; Averett, A.; Caudle, T.; Saylam, K.

2014-12-01

We are using airborne lidar and satellite-based radar interferometry (InSAR) to quantify short-term (months to years) and longer-term (decades) subsidence in the area surrounding two large (100- to 200-m diameter) sinkholes that formed above Permian bedded salt in 1980 and 2002 in the Wink area, west Texas. Radar interferograms constructed from synthetic aperture radar data acquired between 2008 and 2011 with the ALOS PALSAR L-band satellite-borne instrument reveal local areas that are subsiding at rates that reach a few cm per month. Subsiding areas identified on radar interferograms enable labor-intensive ground investigations (such as microgravity surveys) to focus on areas where subsidence is occurring and shallow-source mass deficits might exist that could be sites of future subsidence or collapse. Longer-term elevation changes are being quantified by comparing digital elevation models (DEMs) constructed from high-resolution airborne lidar data acquired over a 32-km2 area in 2013 with older, lower-resolution DEMs constructed from data acquired during the NASA- and NGA-sponsored Shuttle Radar Topographic Mission in February 2000 and from USGS aerial photogrammetry-derived topographic data from the 1960s. Total subsidence reaches more than 10 m over 45 years in some areas. Maximum rates of subsidence measured on annual (from InSAR) and decadal (from lidar) time scales are about 0.25 m/yr. In addition to showing the extent and magnitude of subsidence at the 1980 and 2002 sinkholes, comparison of the 2013 lidar-derived DEM with the 1960s photogrammetry-derived DEM revealed other locations that have undergone significant (more than 1 m) elevation change since the 1960s, but show no evidence of recent (2008 to 2011) ground motion from satellite radar interferograms. Regional coverage obtained by radar interferometry and local coverage obtained with airborne lidar show that areas of measurable subsidence are all within a few km of the 1980 and 2002 sinkholes.

A GIS analysis of the relationship between sinkholes, dry-well complaints and groundwater pumping for frost-freeze protection of winter strawberry production in Florida.

PubMed

Aurit, Mark D; Peterson, Robert O; Blanford, Justine I

2013-01-01

Florida is riddled with sinkholes due to its karst topography. Sometimes these sinkholes can cause extensive damage to infrastructure and homes. It has been suggested that agricultural practices, such as sprinkler irrigation methods used to protect crops, can increase the development of sinkholes, particularly when temperatures drop below freezing, causing groundwater levels to drop quickly during groundwater pumping. In the strawberry growing region, Dover/Plant City, Florida, the effects have caused water shortages resulting in dry-wells and ground subsidence through the development of sinkholes that can be costly to maintain and repair. In this study, we look at how frost-freeze events have affected West Central Florida over the past 25 years with detailed comparisons made between two cold-years (with severe frost-freeze events) and a warm year (no frost-freeze events). We analyzed the spatial and temporal correlation between strawberry farming freeze protection practices and the development of sinkholes/dry well complaints, and assessed the economic impact of such events from a water management perspective by evaluating the cost of repairing and drilling new wells and how these compared with using alternative crop-protection methods. We found that the spatial distribution of sinkholes was non-random during both frost-freeze events. A strong correlation between sinkhole occurrence and water extraction and minimum temperatures was found. Furthermore as temperatures fall below 41°F and water levels decrease by more than 20 ft, the number of sinkholes increase greatly (N >10). At this time alternative protection methods such as freeze-cloth are cost prohibitive in comparison to repairing dry wells. In conclusion, the findings from this study are applicable in other agricultural areas and can be used to develop comprehensive water management plans in areas where the abstraction of large quantities of water occur.

A GIS Analysis of the Relationship between Sinkholes, Dry-Well Complaints and Groundwater Pumping for Frost-Freeze Protection of Winter Strawberry Production in Florida

PubMed Central

Aurit, Mark D.; Peterson, Robert O.; Blanford, Justine I.

2013-01-01

Florida is riddled with sinkholes due to its karst topography. Sometimes these sinkholes can cause extensive damage to infrastructure and homes. It has been suggested that agricultural practices, such as sprinkler irrigation methods used to protect crops, can increase the development of sinkholes, particularly when temperatures drop below freezing, causing groundwater levels to drop quickly during groundwater pumping. In the strawberry growing region, Dover/Plant City, Florida, the effects have caused water shortages resulting in dry- wells and ground subsidence through the development of sinkholes that can be costly to maintain and repair. In this study, we look at how frost-freeze events have affected West Central Florida over the past 25 years with detailed comparisons made between two cold-years (with severe frost-freeze events) and a warm year (no frost-freeze events). We analyzed the spatial and temporal correlation between strawberry farming freeze protection practices and the development of sinkholes/dry well complaints, and assessed the economic impact of such events from a water management perspective by evaluating the cost of repairing and drilling new wells and how these compared with using alternative crop-protection methods. We found that the spatial distribution of sinkholes was non-random during both frost-freeze events. A strong correlation between sinkhole occurrence and water extraction and minimum temperatures was found. Furthermore as temperatures fall below 41°F and water levels decrease by more than 20 ft, the number of sinkholes increase greatly (N >10). At this time alternative protection methods such as freeze-cloth are cost prohibitive in comparison to repairing dry wells. In conclusion, the findings from this study are applicable in other agricultural areas and can be used to develop comprehensive water management plans in areas where the abstraction of large quantities of water occur. PMID:23326518

Ash aggregation enhanced by deposition and redistribution of salt on the surface of volcanic ash in eruption plumes.

PubMed

Mueller, Sebastian B; Ayris, Paul M; Wadsworth, Fabian B; Kueppers, Ulrich; Casas, Ana S; Delmelle, Pierre; Taddeucci, Jacopo; Jacob, Michael; Dingwell, Donald B

2017-03-31

Interactions with volcanic gases in eruption plumes produce soluble salt deposits on the surface of volcanic ash. While it has been postulated that saturation-driven precipitation of salts following the dissolution of ash surfaces by condensed acidic liquids is a primary mechanism of salt formation during an eruption, it is only recently that this mechanism has been subjected to detailed study. Here we spray water and HCl droplets into a suspension of salt-doped synthetic glass or volcanic ash particles, and produce aggregates. Deposition of acidic liquid droplets on ash particles promotes dissolution of existing salts and leaches cations from the underlying material surface. The flow of liquid, due to capillary forces, will be directed to particle-particle contact points where subsequent precipitation of salts will cement the aggregate. Our data suggest that volcanically-relevant loads of surface salts can be produced by acid condensation in eruptive settings. Several minor and trace elements mobilised by surface dissolution are biologically relevant; geographic areas with aggregation-mediated ash fallout could be "hotspots" for the post-deposition release of these elements. The role of liquids in re-distributing surface salts and cementing ash aggregates also offers further insight into the mechanisms which preserve well-structured aggregates in some ash deposits.

Ash aggregation enhanced by deposition and redistribution of salt on the surface of volcanic ash in eruption plumes

PubMed Central

Mueller, Sebastian B.; Ayris, Paul M.; Wadsworth, Fabian B.; Kueppers, Ulrich; Casas, Ana S.; Delmelle, Pierre; Taddeucci, Jacopo; Jacob, Michael; Dingwell, Donald B.

2017-01-01

Interactions with volcanic gases in eruption plumes produce soluble salt deposits on the surface of volcanic ash. While it has been postulated that saturation-driven precipitation of salts following the dissolution of ash surfaces by condensed acidic liquids is a primary mechanism of salt formation during an eruption, it is only recently that this mechanism has been subjected to detailed study. Here we spray water and HCl droplets into a suspension of salt-doped synthetic glass or volcanic ash particles, and produce aggregates. Deposition of acidic liquid droplets on ash particles promotes dissolution of existing salts and leaches cations from the underlying material surface. The flow of liquid, due to capillary forces, will be directed to particle-particle contact points where subsequent precipitation of salts will cement the aggregate. Our data suggest that volcanically-relevant loads of surface salts can be produced by acid condensation in eruptive settings. Several minor and trace elements mobilised by surface dissolution are biologically relevant; geographic areas with aggregation-mediated ash fallout could be “hotspots” for the post-deposition release of these elements. The role of liquids in re-distributing surface salts and cementing ash aggregates also offers further insight into the mechanisms which preserve well-structured aggregates in some ash deposits. PMID:28361966

Microenvironmental pH measurement during sodium naproxenate dissolution in acidic medium by UV/vis imaging.

PubMed

Østergaard, Jesper; Jensen, Henrik; Larsen, Susan W; Larsen, Claus; Lenke, Jim

2014-11-01

Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. For this purpose a UV/vis imaging-based approach capable of measuring microenvironmental pH in the vicinity of the solid drug compact as well as monitoring drug dissolution was developed. Using a pH indicating dye real-time spatially resolved measurement of pH was achieved. Sodium naproxenate, can significantly alter the local pH of the dissolution medium, is eventually neutralized and precipitates as the acidic species naproxen. The developed approach is considered useful for detailed studies of pH dependent dissolution phenomena in dissolution testing. Copyright © 2014 Elsevier B.V. All rights reserved.

Mechanism of Dissolution of Envelopes of the Extreme Halophile Halobacterium cutirubrum1

PubMed Central

Onishi, H.; Kushner, D. J.

1966-01-01

Onishi, H. (National Research Council, Ottawa, Ontario, Canada), and D. J. Kushner. Mechanism of dissolution of envelopes of the extreme halophile Halobacterium cutirubrum. J. Bacteriol. 91:646–652. 1966.—Envelopes of Halobacterium cutirubrum dissolved rapidly in media of low ionic strength. Heating partially inhibited breakdown, probably because of nonspecific protein coagulation rather than inactivation of a lytic enzyme(s). Dissolution of envelopes in water did not involve splitting of peptide bonds or protein-lipid bonds, or any extensive breakdown of carbohydrate polymers. Dissolution was increased by alcohols and urea, even at high salt concentrations, but was not affected by metabolic inhibitors. Thus, no evidence was found for a dilution-activated lytic enzyme that contributes to envelope breakdown. Cells of H. cutirubrum were stable in 2 m NaCl, but lysis occurred in 2 m KCl or NH4Cl. This lysis did not involve an extensive breakdown of the envelope. No evidence for different sites of Na+, K+, and NH4+ action was obtained from the pattern of release of envelope constituents in different concentrations of these salts. Ultracentrifugation studies showed that adding salts to envelopes that had been dissolved in water led to a nonspecific reaggregation of envelope material. No difference was seen between the effects of KCl and NaCl, except at 3 to 4 m concentrations where KCl caused more aggregation. The preferential effect of Na+ on intact cells is probably due to its ability specifically to prevent leakage rather than to an overall effect on envelope integrity. Images PMID:5883109

Sinkhole formation by groundwater withdrawal: far west rand, South Africa.

PubMed

Foose, R M

1967-09-01

Sinkholes up to 125 meters wide and 50 meters deep have developed catastrophically in thick unconsolidated debris above pinnacle-weathered dolomite after lowering of the groundwater surface by at least 160 meters. They are caused by shrinkage of desiccated debris, downward migration of debris into bedrock openings, and upward growth of multiple debris "caverns" by roof spalling.

Molten salt bath circulation design for an electrolytic cell

DOEpatents

Dawless, Robert K.; LaCamera, Alfred F.; Troup, R. Lee; Ray, Siba P.; Hosler, Robert B.

1999-01-01

An electrolytic cell for reduction of a metal oxide to a metal and oxygen has an inert anode and an upwardly angled roof covering the inert mode. The angled roof diverts oxygen bubbles into an upcomer channel, thereby agitating a molten salt bath in the upcomer channel and improving dissolution of a metal oxide in the molten salt bath. The molten salt bath has a lower velocity adjacent the inert anode in order to minimize corrosion by substances in the bath. A particularly preferred cell produces aluminum by electrolysis of alumina in a molten salt bath containing aluminum fluoride and sodium fluoride.

Issues of scale, location and geologic terrain related to Salt Lake City and Baltimore-Washington metropolitan areas

USGS Publications Warehouse

Cleaves, E.T.; Godfrey, A.E.; ,

2004-01-01

Planning and development of expanding metropolitan regions require consideration of earth science issues related to issues involving scale, space (location), geologic terrain and physiographic units, and information transfer. This paper explores these matters with examples from the Salt Lake City, Utah area and Mid-Atlantic region of Baltimore-Washington that include water supply and natural hazards (earthquakes, landslides, and sinkholes.) Information transfer methods using physiographic units at national, regional, local and site scales serve to communicate relevant geologic constraint and natural resource information.

Detection of sinkholes or anomalies using full seismic wave fields : [research summary].

DOT National Transportation Integrated Search

2013-04-01

Sinkholes are a common feature of Floridas geology. The limestone that runs throughout the state is acted upon by the constant flow of water, both above and below ground, that changes with wet and dry seasons. Subsurface voids can form, causing ov...

Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs.

PubMed

Galia, E; Nicolaides, E; Hörter, D; Löbenberg, R; Reppas, C; Dressman, J B

1998-05-01

In this paper we seek to verify the differences in dissolution behavior between class I and class II drugs and to evaluate the suitability of two new physiologically based media, of Simulated Gastric Fluid (SGF) and of milk for their ability to forecast trends in the in vivo performance of class II compounds and their formulations. Dissolution behavior of two class I drugs, i.e. acetaminophen and metoprolol, and of three class II drugs, i.e. danazol, mefenamic acid and ketoconazole, was studied with USP Apparatus 2 in water, SGF, milk, Simulated Intestinal Fluid without pancreatin (SIFsp) and in two media simulating the small intestinal contents in the fed (FeSSIF) and fasted (FaSSIF) states, respectively. Class I powders dissolved rapidly in all media tested. Acetaminophen dissolution in milk was slow from one tablet formulation, in all other cases dissolution was more than 85% complete in 15 minutes. The dissolution rate of metoprolol was shown to be dependent on formulation and manufacturing method, and one of the three tablet formulations did not meet compendial specifications (80%/30 minutes). Dissolution behavior of class II drugs was greatly affected by choice of medium. Dissolution from a capsule formulation of danazol proved to be dependent on the concentration of solubilizing agents, with a the 30-fold increase in percentage dissolved within 90 minutes upon changing from aqueous media without surfactants to FaSSIF. Use of FeSSIF or milk as the dissolution medium resulted in an even greater increase in percentage dissolved, 100 and 180-fold respectively. Dissolution of the weak acid mefenamic acid from a capsule formulation is dependent on both pH and bile salt concentration, which leads to an offset between increased bile salt concentration and lower pH in the fed state compared to the fasted state medium. The weak base ketoconazole showed complete dissolution from a tablet formulation in Simulated Gastric Fluid without pepsin (SGFsp) within 30 minutes

The cost of karst subsidence and sinkhole collapse in the United States compared with other natural hazards

USGS Publications Warehouse

Weary, David J.

2015-01-01

Rocks with potential for karst formation are found in all 50 states. Damage due to karst subsidence and sinkhole collapse is a natural hazard of national scope. Repair of damage to buildings, highways, and other infrastructure represents a significant national cost. Sparse and incomplete data show that the average cost of karst-related damages in the United States over the last 15 years is estimated to be at least $300,000,000 per year and the actual total is probably much higher. This estimate is lower than the estimated annual costs for other natural hazards; flooding, hurricanes and cyclonic storms, tornadoes, landslides, earthquakes, or wildfires, all of which average over $1 billion per year. Very few state organizations track karst subsidence and sinkhole damage mitigation costs; none occurs at the Federal level. Many states discuss the karst hazard in their State hazard mitigation plans, but seldom include detailed reports of subsidence incidents or their mitigation costs. Most State highway departments do not differentiate karst subsidence or sinkhole collapse from other road repair costs. Amassing of these data would raise the estimated annual cost considerably. Information from insurance organizations about sinkhole damage claims and payouts is also not readily available. Currently there is no agency with a mandate for developing such data. If a more realistic estimate could be made, it would illuminate the national scope of this hazard and make comparison with costs of other natural hazards more realistic.

Causes and consequences of the sinkhole at El Trébol of Quito, Ecuador - implications for economic damage and risk assessment

NASA Astrophysics Data System (ADS)

Toulkeridis, Theofilos; Rodríguez, Fabián; Arias Jiménez, Nelson; Simón Baile, Débora; Salazar Martínez, Rodolfo; Addison, Aaron; Carreón Freyre, Dora; Mato, Fernando; Díaz Perez, Carmen

2016-09-01

The so-called El Trébol is a critical road interchange in Quito connecting the north and south regions of the city. In addition, it connects Quito with the highly populated Los Chillos Valley, one of the most traveled zones in the Ecuadorian capital. El Trébol was constructed in the late 1960s in order to resolve the traffic jams of the capital city and for that purpose the Machángara River was rerouted through an underground concrete box tunnel. In March 2008, the tunnel contained a high amount of discarded furniture that had been impacting the top portion of the tunnel, compromising the structural integrity. On 31 March 2008 after a heavy rainfall a sinkhole of great proportions formed in the Trébol traffic hub. In the first few minutes, the sinkhole reached an initial diameter of 30 m. The collapse continued to grow in the following days until the final dimensions of 120 m in diameter and some 40 m of depth, revealing the Machángara River at the base of the sinkhole.A state of emergency was declared. The cause of the sinkhole was a result of the lack of monitoring of the older subterranean infrastructure where trash had accumulated and damaged the concrete tunnel that channelized the Machángara River until it was worn away for a length of some 20 m, leaving behind the sinkhole and the fear of recurrence in populated areas.With the intent to understand the causes and consequences of this sinkhole event, rainfall data are shown together with hydrogeological characteristics and a view back to the recent history of sinkhole lineation or arrangement of the city of Quito. The economic impact is also emphasized, where the direct costs of the damage and the reconstruction are presented and compared to indirect costs associated with this socio-natural disaster. These analyses suggest that the costs of indirect financial damage, like time loss or delay, and subsequent higher expenses for different types of vehicles, are equivalent to many times the costs of the

Detection and localization capability of an urban seismic sinkhole monitoring network

NASA Astrophysics Data System (ADS)

Becker, Dirk; Dahm, Torsten; Schneider, Fabian

2017-04-01

Microseismic events linked to underground processes in sinkhole areas might serve as precursors to larger mass dislocation or rupture events which can cause felt ground shaking or even structural damage. To identify these weak and shallow events, a sensitive local seismic monitoring network is needed. In case of an urban environment the performance of local monitoring networks is severely compromised by the high anthropogenic noise level. We study the detection and localization capability of such a network, which is already partly installed in the urban area of the city of Hamburg, Germany, within the joint project SIMULTAN (http://www.gfz-potsdam.de/en/section/near-surface-geophysics/projects/simultan/). SIMULTAN aims to monitor a known sinkhole structure and gain a better understanding of the underlying processes. The current network consists of six surface stations installed in the basement of private houses and underground structures of a research facility (DESY - Deutsches Elektronen Synchrotron). During the started monitoring campaign since 2015, no microseismic events could be unambiguously attributed to the sinkholes. To estimate the detection and location capability of the network, we calculate synthetic waveforms based on the location and mechanism of former events in the area. These waveforms are combined with the recorded urban seismic noise at the station sites. As detection algorithms a simple STA/LTA trigger and a more sophisticated phase detector are used. While the STA/LTA detector delivers stable results and is able to detect events with a moment magnitude as low as 0.35 at a distance of 1.3km from the source even under the present high noise conditions the phase detector is more sensitive but also less stable. It should be stressed that due to the local near surface conditions of the wave propagation the detections are generally performed on S- or surface waves and not on P-waves, which have a significantly lower amplitude. Due to the often

Agents for gallstone dissolution.

PubMed

Pitt, H A; McFadden, D W; Gadacz, T R

1987-02-01

Numerous methods are presently available for gallstone dissolution, including oral bile salts; cholesterol solvents such as mono-octanoin and methyl tert-butyl ether; calcium or pigment solvents such as EDTA and polysorbate; mechanical extraction techniques through a T-tube tract or after endoscopic sphincterotomy; or fragmentation methods such as ultrasonography or electrohydraulic lithotripsy, lasers, and extracorporeal shock waves. Which, if any, of these methods will be appropriate for an individual patient depends on the type of stones, whether they are in the gallbladder or bile ducts, whether access to the biliary tree is available, the patient's age and general medical condition, and the availability of expert radiologists, endoscopists, and newer equipment. In the United States, the only available oral bile salt for cholesterol gallstone dissolution is chenodeoxycholate. Ursodeoxycholate, which is more rapid and less toxic, has not been approved by the Federal Drug Administration. These agents are most effective in thin women with small, floating, radiolucent cholesterol gallstones in a functioning gallbladder. Only about half of this small subset of patients, however, will experience partial or complete dissolution of stones in 6 to 12 months. Moreover, recurrence is very likely, and the potential toxicity of long-term therapy is unknown. Thus, for most patients, cholecystectomy remains the most cost-effective and, perhaps, safest option. Intragallbladder instillation of methyl tert-butyl ether and extracorporeal shock wave therapy are also likely to be applicable to only small subsets of patients and to be associated with high recurrence rates. In patients with retained ductal cholesterol stones and access to the biliary tree, mono-octanoin therapy is advantageous in that it can be begun as soon as cholangiography demonstrates no extravasation. In properly selected patients, a 90 percent success rate with mono-octanoin infusion can be expected within a

Bayou Corne sinkhole : control measurements of State Highway 70 in Assumption Parish, Louisiana.

DOT National Transportation Integrated Search

2014-01-01

This project measured and assessed the surface stability of the portion of LA Highway 70 that is : potentially vulnerable to the Assumption Parish sinkhole. Using Global Positioning Systems (GPS) : enhanced by a real-time network (RTN) of continuousl...

Vitrinite reflectance of sinkhole coals, east central Missouri fire clay district

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laudon, R.C.

1993-03-01

East central Missouri contains numerous sinkholes many of which are filled with commercial quantities of fire clay and some contain small amounts of coal. Vitrinite reflectance averages from 513 samples taken from eleven of these coals ranged from 0.71 to 0.78. Data were remarkably consistent and no local trends were observed. Using Barker and Goldstein (1990) and Barker and Pawlewicz (1986) temperature correlations, these measurements suggest that the coals have been heated to temperatures on the order of 108 C to 128 C (average = 116). These temperatures are considered anomalously high when compared against known geothermal gradients and burialmore » depths for these rocks. The temperatures suggest that the sinkhole coals have been heated by some thermal event, possibly associated with Mississippi Valley type mineralization. These temperatures are consistent with regional trends in the state. This data, when combined with other vitrinite reflectance and fluid inclusion data (right), suggest that southwest Missouri (Tristate) and southeast Missouri (Viburnum Trend) were hot spots, and that temperatures decrease regionally away from these two areas.« less

Molten salt bath circulation design for an electrolytic cell

DOEpatents

Dawless, R.K.; LaCamera, A.F.; Troup, R.L.; Ray, S.P.; Hosler, R.B.

1999-08-17

An electrolytic cell for reduction of a metal oxide to a metal and oxygen has an inert anode and an upwardly angled roof covering the inert mode. The angled roof diverts oxygen bubbles into an upcomer channel, thereby agitating a molten salt bath in the upcomer channel and improving dissolution of a metal oxide in the molten salt bath. The molten salt bath has a lower velocity adjacent the inert anode in order to minimize corrosion by substances in the bath. A particularly preferred cell produces aluminum by electrolysis of alumina in a molten salt bath containing aluminum fluoride and sodium fluoride. 4 figs.

Determination of the carbonate dissolution mechanism of Lactococcus sp.

NASA Astrophysics Data System (ADS)

Yanmiş, Derya; Orhan, Furkan; Güllüce, Medine; Şahin, Fikrettin

2017-04-01

Magnesite, the main source for magnesium and magnesium derivatives, are also commonly used in the production of caustic, dead-burned and fused magnesia. World magnesite resources are estimated to be at 12 billion tonnes mostly located in China, Russia, North Korea, Australia and Turkey. Turkey is the second producer of the magnesite. Magnesite deposits in Turkey are sedimentary magnesite which have been formed in specific conditions as high concentrations of MgSO4 and CO2 and presence of certain organic salts or created by hot or cold dissolution connected with carbonate rocks mainly with dolomites. According to the genesis of magnesite deposits, they have some impurities as calcium, quartz, iron, etc. Impurities of magnesite, especially CaCO3, reduce its economic value and industrial usability. In our previous study, we have performed biotechnologically enrichment of magnesite by Lactococcus sp., which gave significantly important results. However, we had no information about carbonate dissolution mechanism of bacteria. Therefore, it is aimed to reveal the metabolites of Lactococcus sp. and mechanism leading to the carbonate dissolution (MgCO3 and CaCO3).

Reconstructing the internal structure and long-term evolution of hazardous sinkholes combining trenching, electrical resistivity imaging (ERI) and ground penetrating radar (GPR)

NASA Astrophysics Data System (ADS)

Fabregat, Ivan; Gutiérrez, Francisco; Roqué, Carles; Comas, Xavier; Zarroca, Mario; Carbonel, Domingo; Guerrero, Jesús; Linares, Rogelio

2017-05-01

The approaches aimed at characterising specific damaging sinkholes have received limited attention compared with other ground instability phenomena (e.g. landslides). Moreover, the practicality of the trenching technique in combination with numerical dating and retro-deformation analysis for sinkhole site-investigations has been barely explored. This work illustrates the advantages of combining geomorphic mapping, electrical resistivity imaging (ERI), ground penetrating radar (GPR) and trenching for sinkhole characterisation and shows how the trenching technique contributes to fill significant gaps that neither geomorphic nor geophysical methods can address. Two large sinkholes (> 200 m long) related to the interstratal karstification of evaporites and generated by contrasting subsidence mechanisms (sagging, collapse) were investigated in the Fluvia Valley, NE Spain. Although GPR data may provide high resolution information on subsidence-related stratigraphic and structural features at shallow depth, the profiles acquired in the investigated sites with 100 MHz shielded and 40 MHz unshielded antennae provided limited insight into the internal geometry of the sinkholes due to reduced signal penetration related to the presence of conductive clayey material. The ERI sections satisfactorily imaged the general geometry of the sagging and collapse subsidence structures up to depths higher than 100 m and clearly captured the basal contact of the low-resistivity sinkhole fill in the sections with adequate layout and resolution. The trenches, despite their limited depth (ca. 5 m) allowed us to obtain valuable objective information on several key aspects of the subsidence phenomenon: (1) mechanisms (deformation style) and kinematics (progressive versus episodic); (2) limits of ground deformation; (3) temporal evolution (expansion versus contraction); (4) chronology and timing of most recent deformation phase; (5) rates of subsidence and sedimentation; and (6) the role played

Temporal dynamics of flooding, evaporation, and desiccation cycles and observations of salt crust area change at the Bonneville Salt Flats, Utah

NASA Astrophysics Data System (ADS)

Bowen, Brenda B.; Kipnis, Evan L.; Raming, Logan W.

2017-12-01

The Bonneville Salt Flats (BSF) in Utah is a dynamic saline playa environment responding to natural and anthropogenic forces. Over the last century, the saline groundwater from below BSF has been harvested to produce potash via evaporative mining, mostly used as agricultural fertilizers, while the surface halite crust has provided a significant recreational site for land speed racing. Perceptions of changes in the salt crust through time have spurred debates about land use and management; however, little is known about the timescales of natural change as the salt crust responds to climatic parameters that drive flooding, evaporation, and desiccation (FED) cycles that control surface salt growth and dissolution. Climate data over the last 30 years are examined to identify annual patterns in surface water balance at BSF to identify annual and seasonal climate constraints on FED cycles. Landsat satellite data from 1986 to the present are used to map the areal extent of the surface halite salt crust at BSF at the end of the desiccation season (between August 15 and October 30) annually. Overall, the observed area of the desiccation-stage BSF halite crust has varied from a maximum of 156 km2 in 1993 to a minimum of 72 km2 in 2014 with an overall trend of declining area of halite observed over the 30 years of analysis. Climatic variables that influence FED cycles and seasonal salt dissolution and precipitation have also varied through this time period; however, the relationship between surface water fluxes and salt crust area do not clearly correlate, suggesting that other processes are influencing the extent of the salt. Intra-annual analyses of salt area and weather illustrate the importance of ponded surface water, wind events, and microtopography in shaping a laterally extensive but thin and ephemeral halite crust. Examination of annual to decadal changes in salt crust extent and environmental parameters at BSF provides insights into the processes driving change and

Use of a constant electrode-separation resistivity survey to locate buried cavities associated with regolith-collapse sinkholes in southern Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weibel, C.P.; Panno, S.V.; Heigold, P.C.

1994-04-01

Three regolith-collapse sinkholes formed near a school and a church in the southern Illinois village of Dongola (Union County) during the spring of 1993. The appearance of the sinkholes over a 3-month period coincided with development of a new municipal well, which was drilled through clay-rich, valley-fill sediment into karstified limestone bedrock. The piezometric surface of the limestone aquifer is above land surface, indicating an upward hydraulic gradient in the valley and that the valley-fill is acting as a confining unit. Pumping during development of the well lowered the piezometric surface of the limestone aquifer to an elevation below themore » base of the valley-fill. It is hypothesized that drainage of water from the sediments, the resulting loss of both hydrostatic pressure and buoyant force in overlying sediments, increased intergranular pressure, and the initiation of ground-water flow toward the well resulted in rapid sediment transport, subsurface erosion, and subsequent collapse of the valley-fill sediment. The sinkholes follow an approximately east-west alignment, which is consistent with one of the two dominant alignments of nearby joint-controlled caves. A constant electrode-separation resistivity survey of the school playground was conducted to locate areas that might contain incipient sinkholes. The survey revealed a linear, positive resistivity anomaly, between 5 and 10 m wide, and with a trend that either intersects or is immediately adjacent to the three sinkholes. The anomaly is interpreted to be a series of pumping-induced cavities in the valley-fill sediments that formed over a pre-existing crevice in the karstified bedrock limestone.« less

The effect of sodium chloride on the dissolution of calcium silicate hydrate gels.

PubMed

Hill, J; Harris, A W; Manning, M; Chambers, A; Swanton, S W

2006-01-01

The use of cement based materials will be widespread in the long-term management of radioactive materials in the United Kingdom. One of the applications could be the Nirex reference vault backfill (NRVB) as an engineered barrier within a deep geological repository. NRVB confers alkaline conditions, which would provide a robust chemical barrier through the control of the solubility of some key radionuclides, enhanced sorption and minimised corrosion of steel containers. An understanding of the dissolution of C-S-H gels in cement under the appropriate conditions (e.g., saline groundwaters) is necessary to demonstrate the expected evolution of the chemistry over time and to provide sufficient cement to buffer the porewater conditions for the required time. A programme of experimental work has been undertaken to investigate C-S-H gel dissolution behaviour in sodium chloride solutions and the effect of calcium/silicon ratio (C/S), temperature and cation type on this behaviour. Reductions in calcium concentration and pH values were observed with samples equilibrated at 45 degrees C compared to those prepared at 25 degrees C. The effect of salt cation type on salt-concentration dependence of the dissolution of C-S-H gels was investigated by the addition of lithium or potassium chloride in place of sodium chloride for gels with a C/S of 1.0 and 1.8. With a C/S of 1.0, similar increases in dissolved calcium concentration with increasing ionic strength were recorded for the different salts. However, at a C/S of 1.8, anomalously high calcium concentrations were observed in the presence of lithium.

Insight into the Development of Dissolution Media for BCS Class II Drugs: A Review from Quality Control and Prediction of In Vivo Performance Perspectives.

PubMed

Wu, Chunnuan; Liu, Yan; He, Zhonggui; Sun, Jin

2016-01-01

To assess in vivo behavior through in vitro method, the dissolution test is mostly used, both for quality control (QC) and for development purpose. In view of the fact that a dissolution test can hardly achieve two goals at the same time, the design of dissolution testing generally varies along with the development stage of drug products and therefore the selection of dissolution media may change with the goals of the dissolution test. To serve the QC purpose, a dissolution medium is designed to provide a sink condition; for development purpose, the dissolution medium is required to simulate the physiological conditions in the gastrointestinal tract as far as possible. In this review, we intended to provide an initial introduction to the various dissolution media applied for QC and formulation development purposes for poorly water soluble drugs. We focused on these methods like addition of cosolvents, surfactants and utilization of biphasic media, applied to provide sink conditions which are difficult to be achieved by simple aqueous buffers for lipophilic drugs, and introduced the development of physiologically relevant media for human and animals like dog and rat with respect to the choice of buffers, bile salts, lipids and so on. In addition, we further discussed the influence of biorelevant dissolution media on the modification of drug Biopharmaceutical Classification System (BCS) classification, especially for BCS class II drugs with low solubility and high permeability, the solubility of which is relatively sensitive to the presence of bile salts and lipids.

The initial stages of NaCl dissolution: Ion or ion pair solvation?

NASA Astrophysics Data System (ADS)

Klimes, Jiri; Michaelides, Angelos

2009-03-01

The interaction of water with rock salt (NaCl) is important in a wide variety of natural processes and human activities. A lot is known about NaCl dissolution at the macroscopic level but we do not yet have a detailed atomic scale picture of how salt crystals dissolve. Here we report an extensive series of density functional theory, forcefield and molecular dynamics studies of water clusters at flat and defective NaCl surfaces and NaCl clusters. The focus is on answering seemingly elementary questions such as how many water molecules are needed before it becomes favorable to extract an ion or a pair of ions from the crystal or the cluster. It turns out, however, that the answers to these questions are not so straightforward: below a certain number of water molecules (˜ 12) solvation of individual ions is less costly and above this number solvation of ion pairs is favored. These results reveal a hitherto unknown complexity in the NaCl dissolution process born out of a subtle interplay between water-water and water-ion interactions.

In Situ Salt Formation during Melt Extrusion for Improved Chemical Stability and Dissolution Performance of a Meloxicam-Copovidone Amorphous Solid Dispersion.

PubMed

Haser, Abbe; Cao, Tu; Lubach, Joseph W; Zhang, Feng

2018-03-05

As the pipeline for poorly soluble compounds continues to grow, drug degradation during melt extrusion must be addressed. We present a novel method for stabilizing a thermally labile drug substance while preserving its physical stability and even improving its dissolution performance. In a previous study, we found that incorporating meglumine during extrusion of meloxicam results in chemical stabilization that cannot be achieved using process optimization alone. The purpose of this study is to understand the mechanism behind this stabilization and its impact on the performance of a meloxicam-Kollidon VA64 amorphous solid dispersion. The meloxicam concentration was maintained at 10% (w/w) for blends with and without meglumine. The optimal meglumine blend contained an equimolar amount of meloxicam to meglumine with the remainder consisting of Kollidon VA64. Both formulations were processed with optimized extrusion conditions and analyzed by HPLC for purity. Meglumine at a 1:1 molar ratio with meloxicam results in 100% purity of meloxicam after melt extrusion. Solid-state NMR revealed a proton transfer between the meloxicam and meglumine indicating an in situ salt formation. During non-sink dissolution, the meglumine ASD enables meloxicam to maintain supersaturatation (≅50 times more than meloxicam free acid) for >7.25 h. The ASD without meglumine began precipitating 2.25 h following the pH shift. The ASDs were placed at 40 °C/75% RH for 6 months, and their stability was assessed. No significant chemical degradation, recrystallization, or significant moisture uptake was observed after six months' storage at 40 °C/75% RH.

In vivo canine studies of a Sinkhole valve and vascular graft coated with biocompatible PU-PEO-SO3.

PubMed

Han, D K; Lee, K B; Park, K D; Kim, C S; Jeong, S Y; Kim, Y H; Kim, H M; Min, B G

1993-01-01

PU-PEO-SO3 was applied as a coating material over a newly designed Sinkhole bileaflet PU heart valve and a porous PU vascular graft. Performance and biocompatibility were evaluated using an in vivo canine shunt system between the right ventricle and pulmonary artery. The survival periods in three implantations were 14, 24, and 39 days, during which no mechanical failure occurred in any Sinkhole valve or vascular graft. Scanning electron microscopy (SEM) studies demonstrated much less platelet adhesion and thrombus formation on PU-PEO-SO3 grafts than on PU vascular grafts. Cracks in the valve leaflet were occasionally observed on PU surfaces, but not on PU-PEO-SO3. After a 39 day implantation, calcium deposition on vascular grafts was decreased as compared with valve leaflets, and calcification on PU-PEO-SO3 was much lower than on PU. These results suggest that Sinkhole valves and vascular grafts are promising, and PU-PEO-SO3 as a coating material is more blood compatible, biostable, and calcification resistant in vivo than in untreated PU.

Monitoring and modeling of sinkhole-related subsidence in west-central Florida mapped from InSAR and surface observations

NASA Astrophysics Data System (ADS)

Kiflu, H.; Oliver-Cabrera, T.; Robinson, T.; Wdowinski, S.; Kruse, S.

2017-12-01

Sinkholes in Florida cause millions of dollars in damage to infrastructure each year. Methods of early detection of sinkhole-related subsidence are clearly desirable. We have completed two years of monitoring of selected sinkhole-prone areas in west central Florida with XXX data and analysis with XXX algorithms. Filters for selecting targets with high signal-to-noise ratio and subsidence over this time window (XX-2015-XX-2017) are being used to select sites for ground study. A subset of the buildings with InSAR-detected subsidence indicated show clear structural indications of subsidence in the form of cracks in walls and roofs. Comsol Multiphysics models have been developed to describe subsidence at the rates identified from the InSAR analysis (a few mm/year) and on spatial scales observed from surface observations, including structural deformation of buildings and ground penetrating radar images of subsurface deformation (length scales of meters to tens of meters). These models assume cylindrical symmetry and deformation of elastic and poroelastic layers over a growing sphering void.

A Quaternary paleolake in a sinkhole at Cassis (SE France) : a geomorphology and geophysical study

NASA Astrophysics Data System (ADS)

Romey, C.; Rochette, P.; Vella, C.; Arfib, B.; Champollion, C.; Dussouillez, P.; Hermitte, D.; Parisot, J.-C.

2012-04-01

The Lower Provence and the Massif des Calanques, near Marseille, are a key area in understanding the mechanisms of evolution of the Mediterranean climate and the study of human impact on the local environment during the Quaternary. However, a continuous continental record of paleoenvironment in coastal Provence was not previously available. Looking for such a record, we discovered in a coastal alluvial plain a small paleolake filling a sinkhole that occurred in a marl sequence topping pure limestones at an altitude of 80 m, and a distance to the sea of 2 km. The sinkhole is close to the outlet of a small catchment area of about 8 km2. Limestone is massive but much fractured and therefore suitable for the development of karst. The drilling sedimentary sequence of 50 meters is mainly resulting from the weathering of Cretaceous marls. It consists of 5 meters of oxidized brown clay deposit which covers 45 meters of laminated lacustrine gray clay with sandy past. Cretaceous marls are at the base of the sequence. The presence of marls pebbles in the last meters of the sequence reflects the collapse of the sinkhole. The lacustrine clay was probably deposed during stages isotope 2 to 4 (48 ± 3 ka C14 date at 23 meters depth), whereas brown clay deposit was interpreted as Holocene paleosol. Combination of surface observation, drilling and geophysical studies (gravimetry and Electrical Resistivity Tomography) allows to constraint the geometry of the paleo-polje that formed during glacial period. Lake diameter was likely of the order of 200 m. It evolved from a deep lake to a swamp (probably Holocene, dating in progress) and it was drained in roman times for agriculture. Locally, this discovery has implications for the understanding of karst processes and water resources. The relationship between the sinkhole, rooted at circa 100 m below surface according to gravimetric modeling and the underground karstic river of Bestouan is strongly suggested by underwater exploration and

Carbonate dissolution rates in high salinity brines: Implications for post-Noachian chemical weathering on Mars

NASA Astrophysics Data System (ADS)

Phillips-Lander, Charity M.; Parnell, S. R.; McGraw, L. E.; Elwood Madden, M. E.

2018-06-01

.12 log mol m-2 s-1), while dissolution slowed in both NaCl solutions (0.1 mol kg-1; -8.23 ± 0.10 log mol m-2 s-1 and (5.7 mol kg-1; -8.44 ± 0.11 log mol m-2 s-1), as well as near-saturated MgSO4 brine (2.7 mol kg-1; -8.35 ± 0.05 log mol m-2 s-1). The slowest calcite dissolution rates observed in the near-saturated NaCl brine. Magnesite dissolution rates were ∼5 times faster in the dilute salt solutions relative to UPW, but similar to UPW (-8.47 ± 0.06 log mol m-2 s-1) in near-saturated Na2SO4 brines (-8.41 ± 0.18 log mol m-2 s-1). Magnesite dissolution slowed significantly in near-saturated CaCl2 brine (-9.78 ± 0.10 log mol m-2 s-1), likely due to the significantly lower water activity in these experiments. Overall, magnesite dissolution rates are slower than calcite dissolution rates and follow the trend: All dilute salt solutions >2.5 mol kg-1 Na2SO4 ≈ UPW > 5.7 mol kg-1 NaCl >> 9 mol kg-1 CaCl2. Calcite rates follow the trend 3 mol kg-1 MgCl2 > 2.5 mol kg-1 Na2SO4 ≈ UPW ≈ all dilute salt solutions >2.7 mol kg-1 MgSO4 ≈ 5.7 mol kg-1 NaCl. Magnesite dissolution rates in salt solutions generally decrease with decreasing aH2O in both chloride and sulfate brines, which indicates water molecules act as ligands and participate in the rate-limiting magnesite dissolution step. However, there is no general trend associated with water activity observed in the calcite dissolution rates. Calcite dissolution accelerates in near-saturated MgCl2, but slows in near-saturated NaCl brine despite both brines having similar water activities (aH2O = 0.73 and 0.75, respectively). High Mg calcite was observed as a reaction product in the near-saturated MgCl2, indicating Mg2+ from solution likely substituted for Ca2+ in the initial calcite, releasing additional Ca2+ into solution and increasing the observed calcite dissolution rate. Calcite dissolution rates also increase slightly as Na2SO4 concentration increases, while calcite dissolution rates slow slightly with increasing

Solid-state characterization and dissolution properties of meloxicam-moringa coagulant-PVP ternary solid dispersions.

PubMed

Noolkar, Suhail B; Jadhav, Namdeo R; Bhende, Santosh A; Killedar, Suresh G

2013-06-01

The effect of ternary solid dispersions of poor water-soluble NSAID meloxicam with moringa coagulant (obtained by salt extraction of moringa seeds) and polyvinylpyrrolidone on the in vitro dissolution properties has been investigated. Binary (meloxicam-moringa and meloxicam-polyvinylpyrrolidone (PVP)) and ternary (meloxicam-moringa-PVP) systems were prepared by physical kneading and ball milling and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffractometry. The in vitro dissolution behavior of meloxicam from the different products was evaluated by means of United States Pharmacopeia type II dissolution apparatus. The results of solid-state studies indicated the presence of strong interactions between meloxicam, moringa, and PVP which were of totally amorphous nature. All ternary combinations were significantly more effective than the corresponding binary systems in improving the dissolution rate of meloxicam. The best performance in this respect was given by the ternary combination employing meloxicam-moringa-PVP ratio of [1:(3:1)] prepared by ball milling, with about six times increase in percent dissolution rate, whereas meloxicam-moringa (1:3) and meloxicam-PVP (1:4) prepared by ball milling improved dissolution of meloxicam by almost 3- and 2.5-folds, respectively. The achieved excellent dissolution enhancement of meloxicam in the ternary systems was attributed to the combined effects of impartation of hydrophilic characteristic by PVP, as well as to the synergistic interaction between moringa and PVP.

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

PubMed Central

Seo, Jae Hong; Park, Jung Bae; Choi, Woong-Kee; Park, Sunhwa; Sung, Yun Jin; Oh, Euichaul; Bae, Soo Kyung

2015-01-01

Objective Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavailability of cilostazol. Methods Cilostazol mesylate and cilostazol besylate were synthesized from cilostazol by acid addition reaction with methane sulfonic acid and benzene sulfonic acid, respectively. The salt preparations were characterized by nuclear magnetic resonance spectroscopy. The water contents, hygroscopicity, stress stability, and photostability of the two cilostazol salts were also determined. The dissolution profiles in various pH conditions and pharmacokinetic studies in rats were compared with those of cilostazol-free base. Results The two cilostazol salts exhibited good physicochemical properties, such as nonhygroscopicity, stress stability, and photostability, which make it suitable for the preparation of pharmaceutical formulations. Both cilostazol mesylate and cilostazol besylate showed significantly improved dissolution rate and extent of drug release in the pH range 1.2–6.8 compared to the cilostazol-free base. In addition, after oral administration to rats, cilostazol mesylate and cilostazol besylate showed increases in Cmax and AUCt of approximately 3.65- and 2.87-fold and 3.88- and 2.94-fold, respectively, compared to cilostazol-free base. Conclusion This study showed that two novel salts of cilostazol, such as cilostazol mesylate and cilostazol besylate, could be used to enhance its oral absorption. The findings warrant further preclinical and clinical studies on cilostazol mesylate and cilostazol besylate at doses lower than the usually recommended dosage, so that it can be established as an alternative to the marketed cilostazol tablet. PMID:26251575

DNA profiling of Tilapia guinasana, a species endemic to a single sinkhole, to determine the genetic divergence between color forms.

PubMed

Nxomani, C; Ribbink, A J; Kirby, R

1999-06-01

Northwestern South Africa and Namibia contain a number of sinkholes in the dolomitic rock formations found in this area. These contain isolated populations of Tilapia. Most contain Tilapia sparmanii, but the one in Namibia, Guinas, is of particular interest as it contains the endemic species, Tilapia guinasana, which exhibits none sex-limited polychromatisms, which is unique for Tilapia. This sinkhole is under environmental threat, particularly as a result of being a recreational diving site. This study, using randomly amplified polymorphic DNA sequences (RAPDs), when analyzed using analysis of variance (ANOVA), shows that the colour forms of Tilapia guinasana are genetically distinct. This confirms previous evidence that assortative mating between color forms takes place. The various possible hypotheses for the occurrence and genetic stability of the color polymorphism are discussed. Further, a new hypothesis is put forward based on a need to maximize outbreeding in fully isolated population with no possibility of increase in size above the maximum and limited carrying capacity of the sinkhole.

Salt and cocrystals of sildenafil with dicarboxylic acids: solubility and pharmacokinetic advantage of the glutarate salt.

PubMed

Sanphui, Palash; Tothadi, Srinu; Ganguly, Somnath; Desiraju, Gautam R

2013-12-02

Sildenafil is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. Because of poor aqueous solubility of the drug, the citrate salt, with improved solubility and pharmacokinetics, has been marketed. However, the citrate salt requires an hour to reach its peak plasma concentration. Thus, to improve solubility and bioavailability characteristics, cocrystals and salts of the drug have been prepared by treating aliphatic dicarboxylic acids with sildenafil; the N-methylated piperazine of the drug molecule interacts with the carboxyl group of the acid to form a heterosynthon. Salts are formed with oxalic and fumaric acid; salt monoanions are formed with succinic and glutaric acid. Sildenafil forms cocrystals with longer chain dicarboxylic acids such as adipic, pimelic, suberic, and sebacic acids. Auxiliary stabilization via C-H···O interactions is also present in these cocrystals and salts. Solubility experiments of sildenafil cocrystal/salts were carried out in 0.1N HCl aqueous medium and compared with the solubility of the citrate salt. The glutarate salt and pimelic acid cocrystal dissolve faster than the citrate salt in a two hour dissolution experiment. The glutarate salt exhibits improved solubility (3.2-fold) compared to the citrate salt in water. Solubilities of the binary salts follow an inverse correlation with their melting points, while the solubilities of the cocrystals follow solubilities of the coformer. Pharmacokinetic studies on rats showed that the glutarate salt exhibits doubled plasma AUC values in a single dose within an hour compared to the citrate salt. The high solubility of glutaric acid, in part originating from the strained conformation of the molecule and its high permeability, may be the reason for higher plasma levels of the drug.

Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt

PubMed Central

Sanphui, Palash; Bolla, Geetha; Nangia, Ashwini; Chernyshev, Vladimir

2014-01-01

Acemetacin (ACM) is a non-steroidal anti-inflammatory drug (NSAID), which causes reduced gastric damage compared with indomethacin. However, acemetacin has a tendency to form a less soluble hydrate in the aqueous medium. We noted difficulties in the preparation of cocrystals and salts of acemetacin by mechanochemical methods, because this drug tends to form a hydrate during any kind of solution-based processing. With the objective to discover a solid form of acemetacin that is stable in the aqueous medium, binary adducts were prepared by the melt method to avoid hydration. The coformers/salt formers reported are pyridine carboxamides [nicotinamide (NAM), isonicotinamide (INA), and picolinamide (PAM)], caprolactam (CPR), p-aminobenzoic acid (PABA), and piperazine (PPZ). The structures of an ACM–INA cocrystal and a binary adduct ACM–PABA were solved using single-crystal X-ray diffraction. Other ACM cocrystals, ACM–PAM and ACM–CPR, and the piperazine salt ACM–PPZ were solved from high-resolution powder X-ray diffraction data. The ACM–INA cocrystal is sustained by the acid⋯pyridine heterosynthon and N—H⋯O catemer hydrogen bonds involving the amide group. The acid⋯amide heterosynthon is present in the ACM–PAM cocrystal, while ACM–CPR contains carboxamide dimers of caprolactam along with acid–carbonyl (ACM) hydrogen bonds. The cocrystals ACM–INA, ACM–PAM and ACM–CPR are three-dimensional isostructural. The carboxyl⋯carboxyl synthon in ACM–PABA posed difficulty in assigning the position of the H atom, which may indicate proton disorder. In terms of stability, the salts were found to be relatively stable in pH 7 buffer medium over 24 h, but the cocrystals dissociated to give ACM hydrate during the same time period. The ACM–PPZ salt and ACM–nicotinamide cocrystal dissolve five times faster than the stable hydrate form, whereas the ACM–PABA adduct has 2.5 times faster dissolution rate. The pharmaceutically acceptable piperazine

Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt.

PubMed

Sanphui, Palash; Bolla, Geetha; Nangia, Ashwini; Chernyshev, Vladimir

2014-03-01

Acemetacin (ACM) is a non-steroidal anti-inflammatory drug (NSAID), which causes reduced gastric damage compared with indomethacin. However, acemetacin has a tendency to form a less soluble hydrate in the aqueous medium. We noted difficulties in the preparation of cocrystals and salts of acemetacin by mechanochemical methods, because this drug tends to form a hydrate during any kind of solution-based processing. With the objective to discover a solid form of acemetacin that is stable in the aqueous medium, binary adducts were prepared by the melt method to avoid hydration. The coformers/salt formers reported are pyridine carboxamides [nicotinamide (NAM), isonicotinamide (INA), and picolinamide (PAM)], caprolactam (CPR), p-aminobenzoic acid (PABA), and piperazine (PPZ). The structures of an ACM-INA cocrystal and a binary adduct ACM-PABA were solved using single-crystal X-ray diffraction. Other ACM cocrystals, ACM-PAM and ACM-CPR, and the piperazine salt ACM-PPZ were solved from high-resolution powder X-ray diffraction data. The ACM-INA cocrystal is sustained by the acid⋯pyridine heterosynthon and N-H⋯O catemer hydrogen bonds involving the amide group. The acid⋯amide heterosynthon is present in the ACM-PAM cocrystal, while ACM-CPR contains carboxamide dimers of caprolactam along with acid-carbonyl (ACM) hydrogen bonds. The cocrystals ACM-INA, ACM-PAM and ACM-CPR are three-dimensional isostructural. The carboxyl⋯carboxyl synthon in ACM-PABA posed difficulty in assigning the position of the H atom, which may indicate proton disorder. In terms of stability, the salts were found to be relatively stable in pH 7 buffer medium over 24 h, but the cocrystals dissociated to give ACM hydrate during the same time period. The ACM-PPZ salt and ACM-nicotinamide cocrystal dissolve five times faster than the stable hydrate form, whereas the ACM-PABA adduct has 2.5 times faster dissolution rate. The pharmaceutically acceptable piperazine salt of acemetacin exhibits superior

Sinkholes Due to Groundwater Withdrawal in Tazerbo Wellfield, SE Libya.

PubMed

Alfarrah, Nawal; Berhane, Gebremedhin; Hweesh, Abdelrahim; Walraevens, Kristine

2017-07-01

The desert of eastern Libya forms one of the most arid regions of the Sahara. The Great Man-Made River Project (GMRP) was established. It transports millions of cubic meters of water a day from desert wellfields to the coastal cities, where over 80% of the population lives. The Tazerbo Wellfield is one of the wellfields designed within the GMRP, delivering water to the eastern coast of Libya through an underground pipe network. Tazerbo Wellfield consists of 108 production wells; each well was designed to pump 100 L/s. The planned total groundwater withdrawal from all wells is 1 million m 3 /d. The deep sandstone aquifer (Nubian sandstone) is covered by a thick mudstone-siltstone aquitard and is being heavily pumped. The aquifer and fine-grained sediments of the aquitard may be compacted resulting in land subsidence as a result of high exploitation. Local sinkholes have developed in the area of Tazerbo since the start of the pumping from the wellfield in 2004. These sinkholes have been caused mainly by lowering of the piezometric heads due to the withdrawal of groundwater. In this study, a hydrogeological investigation is presented about the effect of large groundwater pumping from the Nubian sandstone aquifer in Tazerbo Wellfield, SE Libya, based on physical parameters for 108 production wells and 23 observation wells. © 2017, National Ground Water Association.

Experiments and Modeling in Support of Generic Salt Repository Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bourret, Suzanne Michelle; Stauffer, Philip H.; Weaver, Douglas James

Salt is an attractive material for the disposition of heat generating nuclear waste (HGNW) because of its self-sealing, viscoplastic, and reconsolidation properties (Hansen and Leigh, 2012). The rate at which salt consolidates and the properties of the consolidated salt depend on the composition of the salt, including its content in accessory minerals and moisture, and the temperature under which consolidation occurs. Physicochemical processes, such as mineral hydration/dehydration salt dissolution and precipitation play a significant role in defining the rate of salt structure changes. Understanding the behavior of these complex processes is paramount when considering safe design for disposal of heat-generatingmore » nuclear waste (HGNW) in salt formations, so experimentation and modeling is underway to characterize these processes. This report presents experiments and simulations in support of the DOE-NE Used Fuel Disposition Campaign (UFDC) for development of drift-scale, in-situ field testing of HGNW in salt formations.« less

Sinkhole-type subsidence over abandoned coal mines in St. David, Illinois. Mine subsidence report, St. David, Illinois. A field survey and analysis of mine subsidence of abandoned coal mines in St. David, Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wildanger, E.G.; Mahar, J.; Nieto, A.

1980-01-01

This study examined the geologic data, mining history, and subsidence trends of the St. David region. Mine subsidence has occurred due to collapse of the abandoned mine workings. The known subsidence areas have been mapped and described. Results of the study include: (1) St. David has been undermined by both large shipping mines and smaller local mines; (2) sinkholes will continue to develop in this area in response to rock failure and roof collapse above the abandoned mine workings; (3) some primary factors that contribute to the sinkhole problems are the undermining and roof rock composition; (4) sinkholes will bemore » smaller in the future; (5) ten of the 63 sinkholes occurred close enough to structures to cause damage, and only six sinkholes caused damage; (6) ways to minimize potential damage to future homes from sinkhole subsidence are manageable; (7) threats to residents lie in the collapse of heavy walls, brick chimneys, breaks in gas, water, or electrical lines; and (8) location of future subsidence is not predictable. (DP)« less

Designing a dynamic dissolution method: a review of instrumental options and corresponding physiology of stomach and small intestine.

PubMed

Culen, Martin; Rezacova, Anna; Jampilek, Josef; Dohnal, Jiri

2013-09-01

Development of new pharmaceutical compounds and dosage forms often requires in vitro dissolution testing with the closest similarity to the human gastrointestinal (GI) tract. To create such conditions, one needs a suitable dissolution apparatus and the appropriate data on the human GI physiology. This review discusses technological approaches applicable in biorelevant dissolutions as well as the physiology of stomach and small intestine in both fasted and fed state, that is, volumes of contents, transit times for water/food and various solid oral dosage forms, pH, osmolality, surface tension, buffer capacity, and concentrations of bile salts, phospholipids, enzymes, and Ca(2+) ions. The information is aimed to provide clear suggestions on how these conditions should be set in a dynamic biorelevant dissolution test. Copyright © 2013 Wiley Periodicals, Inc.

Hydrogeological perturbations along the Dead Sea coast revealed by submarine sinkholes, Lisan and Ghor al Haditha, Jordan

NASA Astrophysics Data System (ADS)

Closson, D.; Abou Karaki, N.; Milisavljevic, N.; Pasquali, P.; Holecz, F.; Bouaraba, A.

2012-04-01

For several decades, surface water and groundwater located in the closed Dead Sea basin experience excessive exploitation. In fifty years, the level of the terminal lake has fallen by about 30 meters and its surface shrunk by one third. The coastal zone is the one that best shows the stigma of the general environmental degradation. Among these are the sinkholes, landslides and subsidence. For years, these phenomena are relatively well documented, particularly sinkholes and subsidence. Over the past five years, field observations combined with ground deformations measurements by radar interferometric stacking techniques have shown that the intensity (size, frequency) of the collapses is increasing in the most affected part of the southern Dead Sea area. The zones of the dried up Lynch Strait, the Lisan peninsula and Ghor Al Haditha in Jordan seem the most affected. Very high resolution (0.5 to 2 m) GeoEye satellite images have shown that many sinkholes also formed below the level of the Dead Sea. The water transparency allows observations up to several meters deep. These data contribute to the validation of the models developed in connection with the deformation of the fresh/saline water interface due to an imbalance always more pronounced between the levels of the surrounding groundwaters and of the terminal lake.

Use of Multibeam-Bathymetry and Seismic-Reflection Data to Investigate the Origin of Seafloor Depressions Along the Southeastern Carbonate Florida Platform

NASA Astrophysics Data System (ADS)

Cunningham, K. J.; Kluesner, J.; Westcott, R. L.; Ebuna, D. R.; Walker, C.

2016-12-01

Numerous large, semicircular, deep submarine depressions on the seafloor of the Miami Terrace (a bathymetric bench that interrupts the Atlantic continental slope on the southeastern carbonate Florida Platform) have been described as submarine sinkholes resulting from freshwater discharge at the seafloor and dissolution of carbonate rock. Multibeam-bathymetry and marine, high-resolution, multichannel 2D and 3D seismic-reflection data acquired over two of these depressions at water depths of about 250 m ("Miami sinkhole") and 336 m ("Key Biscayne sinkhole") indicate the depressions are pockmarks. Seafloor pockmarks are concave, crater-like depressions that form through the outburst or venting of fluid (gas, liquid) at the sea floor and are important seabed features that provide information about fluid flow on continental margins. Both the "Miami sinkhole" and "Key Biscayne sinkhole" (about 25 and 48m deep, respectively) have a seismic-chimney structure beneath them that indicates an origin related to seafloor fluid expulsion, as supported by multi-attribute analysis of the "Key Biscayne sinkhole". Further, there is no widening of the depressions with depth, as in the Fort Worth Basin, where downward widening of seismic, sub-circular, karst-collapse structures is common. However, hypogenic karst dissolution is not ruled out as part of the evolution of the two depressions. Indeed, a hypogenic karst pipe plausibly extends downward from the bottom of "Key Biscayne sinkhole", providing a passageway for focused upward flow of fluids to the seafloor. In "Key Biscayne sinkhole", the proposed karst pipe occurs above the underlying seismic chimney that contains flat bright spots (a hydrocarbon indicator) in the seismic data plausibly showing fluids are currently trapped beneath the pockmark within a tightly folded popup structure. The Miami Terrace depressions have seismic-reflection features similar to modern pockmarks imaged on the Maldives carbonate platform. The seismic

Salt-enhanced chemical weathering of building materials and bacterial mineralization of calcium carbonate as a treatment

NASA Astrophysics Data System (ADS)

Schiro, M.; Ruiz-Agudo, E.; Jroundi, F.; Gonzalez-Muñoz, M. T.; Rodriguez-Navarro, C.

2012-04-01

Salt weathering is an important mechanism contributing to the degradation and loss of stone building materials. In addition to the physical weathering resulting from crystallization pressure, the presence of salts in solution greatly enhances the chemical weathering potential of pore waters. Flow through experiments quantify the dissolution rates of calcite and quartz grains (63-125 micrometer diameter) when subjected to 1.0 ionic strength solutions of MgSO4, MgCl, Na2SO4 or NaCl. Results indicate that the identity of the cation is the primary control over the dissolution rate of both calcite and quartz substrates, with salt-enhanced dissolution occurring most rapidly in Mg2+ bearing solutions. It has been observed that weathering rates of rocks in nature, as well as building stones, are slowed down by naturally occurring or artificially produced patinas. These tend to be bacterially produced, durable mineralized coatings that lend some degree of protection to the underlying stone surface [1]. Our research shows that bacterially produced carbonate coatings can be quite effective at reducing chemical weathering of stone by soluble salts. The calcite-producing-bacteria used in this study were isolated from stone monuments in Granada, Spain [2] and cultivated in an organic-rich culture medium on a variety of artificial and natural substrates (including limestone, marble, sandstone, quartz, calcite single crystals, glass cover-slips, and sintered porous glass). Scanning electron microscopy (FESEM) was used to image bacterial calcite growth and biofilm formation. In-situ atomic force microscopy (AFM) enabled calculation of dissolution rates of untreated and bacterially treated surfaces. 2D-XRD showed the mineralogy and crystallographic orientation of bacterial calcium carbonate. Results indicate that bacterially produced calcite crystals form a coherent, mechanically resistant surface layer in perfect crystallographic continuity with the calcite substrate (self

Geohydrology of the Keechi, Mount Sylvan, Oakwood, and Palestine salt domes in the northeast Texas salt-dome basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carr, J.E.; Halasz, S.J.; Peters, H.B.

1980-01-01

The salt within these domes has penetrated as much as 20,000 feet of Mesozoic and Cenozoic strata, and presently extends to within 120 to 800 feet of the land surface. The salt penetrates or closely underlies major freshwater and salinewater aquifers within the basin. To provide a safe repository for radioactive wastes within one or more of these domes, a thorough understanding of the geohydrology needs to be obtained, and the hydrologic stability of the domes needs to be established for the expected life of the storage facility. Dissolution may exist at all four candidate salt domes, possibly through contactmore » with Cretaceous or Tertiary aquifers, or through fault systems in the vicinity of the domes. Strata overlying and surrounding Palestine and Keechi Salt Domes have been arched into steeply-dipping folds that are complexly faulted. Similar conditions exist at Oakwood and Mount Sylvan Domes, except that the Tertiary strata have been only moderately disturbed. Additional problems concerning the hydrologic stability of Oakwood and Palestine Salt Domes have resulted from the disposal of oil-field salinewater in the cap rock at the Oakwood Dome and previous solution mining of salt at the Palestine Dome.« less

Crystal structure and physicochemical characterization of ambazone monohydrate, anhydrous, and acetate salt solvate.

PubMed

Muresan-Pop, Marieta; Braga, Dario; Pop, Mihaela M; Borodi, Gheorghe; Kacso, Irina; Maini, Lucia

2014-11-01

The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-crystal X-ray diffraction (SC-XRD). Ambazone monohydrate is characterized by an infinite three-dimensional network involving the water molecules, whereas anhydrous ambazone forms a two-dimensional network via hydrogen bonds. The reversible transformation between the monohydrate and anhydrous forms of ambazone was evidenced by thermal analysis, temperature-dependent X-ray powder diffraction and accelerated stability at elevated temperature, and relative humidity (RH). Additionally, a novel ambazone acetate salt solvate form was obtained and its nature was elucidated by SC-XRD. Powder dissolution measurements revealed a substantial solubility and dissolution rate improvement of acetate salt solvated form in water and physiological media compared with ambazone forms. Also, the acetate salt solvate displayed good thermal and solution stability but it transformed to the monohydrate on storage at elevated temperature and RH. Our study shows that despite the requirement for controlled storage conditions, the acetate salt solvated form could be an alternative to ambazone when solubility and bioavailability improvement is critical for the clinical efficacy of the drug product. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

Bayou Corne Sinkhole: Control Measurements of State Highway 70 in Assumption Parish, Louisiana : Research Project Capsule

DOT National Transportation Integrated Search

2012-09-01

The sinkhole located in northern Assumption Parish, Louisiana, threatens : the stability of Highway 70, a state-maintained route. In order to monitor : and mitigate potential damage eff ects on this infrastructure, the Louisiana : Department of Trans...

Holocene environmental change of the northern Caribbean inferred from the sediments of a flooded sinkhole, Cayo Coco, Cuba

NASA Astrophysics Data System (ADS)

Peros, M. C.; Agosta G'meiner, A. M.; Collins, S.

2016-12-01

We present new data on the Holocene environments of the northern Caribbean inferred from the sediments of a flooded sinkhole (Cenote Jennifer) on the island of Cayo Coco in north-central Cuba. Cenote Jennifer is located several meters above sea level and has an average depth of 13 meters. Water chemistry measurements indicate that the water in the sinkhole is highly stratified with a halocline at about 8 meters depth and an anoxic base. A series of sediment cores collected at the center of the sinkhole were analyzed for fossil pollen, microcharcoal, dinoflagellate cysts, elemental geochemistry (by high-resolution XRF core-scanning), and grain size and were dated by Pb-210 and AMS radiocarbon techniques (using well-preserved macrofossils of leaves, bark, and twigs). The results show that sediments first began to accumulate in Cenote Jennifer approximately 9000 years ago and continued until the present. The elemental geochemistry results record increases in elements such as Br, Cl, Ni, and Cu during the 8.2 kyr event which may reflect enhanced deep-ocean upwelling at this time. The fossil pollen data record a succession in vegetation that included cattail marsh, thorny coastal scrubland, dry evergreen forest, and secondary forest communities over the course of the Holocene. Changes in vegetation were driven mostly by relative sea level rise in the early Holocene but climate change was more important by the middle to late Holocene. Hundreds of mm- to cm-scale laminations are also present in the core, many of which represent past hurricane strikes. The microcharcoal and pollen evidence also suggests that prehistoric humans may have settled the area and practiced agriculture as early as 2800 cal yr BP. The findings from Cenote Jennifer highlight the utility of flooded sinkholes as paleoenvironmental archives in tropical kart regions and provide important new data on the hydroclimatology of the northern Caribbean.

An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

DOE Office of Scientific and Technical Information (OSTI.GOV)

O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.

Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH,more » leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.« less

Reactive Melt Extrusion To Improve the Dissolution Performance and Physical Stability of Naproxen Amorphous Solid Dispersions.

PubMed

Liu, Xu; Zhou, Lin; Zhang, Feng

2017-03-06

The purpose of this study was to investigate the reaction between naproxen (NPX) and meglumine (MEG) at elevated temperature and to study the effect of this reaction on the physical stabilities and in vitro drug-release properties of melt-extruded naproxen amorphous solid dispersions (ASDs). Differential scanning calorimetry, hot-stage polarized light microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy analyses demonstrated that in situ salt formation with proton transfer between NPX and MEG occurred at elevated temperature during the melt extrusion process. The amorphous NPX-MEG salt was physically most stable when two components were present at a 1:1 molar ratio. Polymeric carriers, including povidone, copovidone, and SOLUPLUS, did not interfere with the reaction between NPX and MEG during melt extrusion. Compared to the traditional NPX ASDs consisting of NPX and polymer only, NPX-MEG ASDs were physically more stable and remained amorphous following four months storage at 40 °C and 75% RH (relative humidity). Based on nonsink dissolution testing and polarized light microscopy analyses, we concluded that the conventional NPX ASDs composed of NPX and polymers failed to improve the NPX dissolution rate due to the rapid recrystallization of NPX in contact with aqueous medium. The dissolution rate of NPX-MEG ASDs was two times greater than the corresponding physical mixtures and conventional NPX ASDs. This study demonstrated that the acid-base reaction between NPX and MEG during melt extrusion significantly improved the physical stability and the dissolution rate of NPX ASDs.

Calcite Dissolution Kinetics

NASA Astrophysics Data System (ADS)

Berelson, W.; Subhas, A.; Dong, S.; Naviaux, J.; Adkins, J. F.

2016-12-01

A geological buffer for high atmospheric CO2 concentrations is neutralization via reaction with CaCO3. We have been studying the dissolution kinetics of carbonate minerals using labeled 13C calcite and Picarro-based measurements of 13C enrichments in solution DIC. This methodology has greatly facilitated our investigation of dissolution kinetics as a function of water carbonate chemistry, temperature and pressure. One can adjust the saturation state Omega by changing the ion activity product (e.g. adjusting carbonate ion concentration), or by changing the solubility product (e.g. adjusting temperature or pressure). The canonical formulation of dissolution rate vs. omega has been refined (Subhas et al. 2015) and shows distinct non-linear behavior near equilibrium and rates in sea water of 1-3 e-6 g/cm2day at omega = 0.8. Carbonic anhydrase (CA), an enzyme that catalyzes the hydration of dissolved CO2 to carbonic acid, was shown (in concentrations <=0.04 g/L) to enhance the dissolution rate at low degrees of undersaturation by >500x. This result points to the importance of carbonic acid in enhancing dissolution at low degrees of undersaturation. CA activity and abundance in nature must be considered regarding the role it plays in catalyzing dissolution. We also have been investigating the role of temperature on dissolution kinetics. An increase of 16C yields an order of magnitude increase in dissolution rate. Temperature (and P) also change Omega critical, the saturation state where dissolution rates change substantially. Increasing pressure (achieved in a pressure reaction chamber we built) also shifts Omega critical closer to equilibrium and small pressure increases have large impact on dissolution kinetics. Dissolution rates are enhanced by an order of magnitude for a change in pressure of 1500 psi relative to the dissolution rate achieved by water chemistry effects alone for an omega of 0.8. We've shown that the thermodynamic determination of saturation state

Reply to Discussion by Zekai Șen on "Modeling karst spring hydrograph recession based on head drop at sinkholes"

NASA Astrophysics Data System (ADS)

Field, Malcolm S.; Goldscheider, Nico; Li, Guangquan

2018-02-01

We are pleased to learn that the model presented in our paper dealing with the "modeling karst spring hydrograph recession based on head drop at sinkholes," published in the Journal of Hydrology in 2016 (Li et al., 2016), is of interest to readers of this journal. Our study presented a new non-exponential model for assessing spring hydrographs in terms of head drop at flooded sinkholes, as an extension of an earlier model proposed by Li and Field (2014). In both papers, we used two spring hydrographs measured in the St. Marks Karst Watershed in northwest Florida to test the applicability and to verify the validity of our models.

The Pipe Creek Sinkhole biota, a diverse late tertiary continental fossil assemblage from Grant County, Indiana

USGS Publications Warehouse

Farlow, J.O.; Sunderman, J.A.; Havens, J.J.; Swinehart, A.L.; Holman, J.A.; Richards, R.L.; Miller, N.G.; Martin, R.A.; Hunt, R.M.; Storrs, G.W.; Curry, B. Brandon; Fluegeman, R.H.; Dawson, M.; Flint, M.E.T.

2001-01-01

Quarrying in east-central Indiana has uncovered richly fossiliferous unconsolidated sediment buried beneath Pleistocene glacial till. The fossiliferous layer is part of a sedimentary deposit that accumulated in a sinkhole developed in the limestone flank beds of a Paleozoic reef. Plant and animal (mostly vertebrate) remains are abundant in the fossil assemblage. Plants are represented by a diversity of terrestrial and wetland forms, all of extant species. The vertebrate assemblage (here designated the Pipe Creek Sinkhole local fauna) is dominated by frogs and pond turtles, but fishes, birds; snakes and small and large mammals are also present; both extinct and extant taxa are represented. The mammalian assemblage indicates an early Pliocene age (latest Hemphillian or earliest Blancan North American Land Mammal Age). This is the first Tertiary continental biota discovered in the interior of the eastern half of North America.

A Model for Dissolution of Lime in Steelmaking Slags

NASA Astrophysics Data System (ADS)

Sarkar, Rahul; Roy, Ushasi; Ghosh, Dinabandhu

2016-08-01

In a previous study by Sarkar et al. (Metall. Mater. Trans. B 46B:961 2015), a dynamic model of the LD steelmaking was developed. The prediction of the previous model (Sarkar et al. in Metall. Mater. Trans. B 46B:961 2015) for the bath (metal) composition matched well with the plant data (Cicutti et al. in Proceedings of 6th International Conference on Molten Slags, Fluxes and Salts, Stockholm City, 2000). However, with respect to the slag composition, the prediction was not satisfactory. The current study aims to improve upon the previous model Sarkar et al. (Metall. Mater. Trans. B 46B:961 2015) by incorporating a lime dissolution submodel into the earlier one. From the industrial point of view, the understanding of the lime dissolution kinetics is important to meet the ever-increasing demand of producing low-P steel at a low basicity. In the current study, three-step kinetics for the lime dissolution is hypothesized on the assumption that a solid layer of 2CaO·SiO2 should form around the unreacted core of the lime. From the available experimental data, it seems improbable that the observed kinetics should be controlled singly by any one kinetic step. Accordingly, a general, mixed control model has been proposed to calculate the dissolution rate of the lime under varying slag compositions and temperatures. First, the rate equation for each of the three rate-controlling steps has been derived, for three different lime geometries. Next, the rate equation for the mixed control kinetics has been derived and solved to find the dissolution rate. The model predictions have been validated by means of the experimental data available in the literature. In addition, the effects of the process conditions on the dissolution rate have been studied, and compared with the experimental results wherever possible. Incorporation of this submodel into the earlier global model (Sarkar et al. in Metall. Mater. Trans. B 46B:961 2015) enables the prediction of the lime dissolution rate

Numerical modeling of mineral dissolution - precipitation kinetics integrating interfacial processes

NASA Astrophysics Data System (ADS)

Azaroual, M. M.

2016-12-01

The mechanisms of mineral dissolution/precipitation are complex and interdependent. Within a same rock, the geochemical modelling may have to manage kinetic reactions with high ratios between the most reactive minerals (i.e., carbonates, sulfate salts, etc.) and less reactive minerals (i.e., silica, alumino-silicates, etc.). These ratios (higher than 10+6) induce numerical instabilities for calculating mass and energy transfers between minerals and aqueous phases at the appropriate scales of time and space. The current scientific debate includes: i) changes (or not) of the mineral reactive surface with the progress of the dissolution/precipitation reactions; ii) energy jumps (discontinuity) in the thermodynamic affinity function of some dissolution/precipitation reactions and iii) integration of processes at the "mineral - aqueous solution" interfaces for alumino-silicates, silica and carbonates. In recent works dealing with the specific case of amorphous silica, measurements were performed on nano-metric cross-sections indicating the presence of surface layer between the bulk solution and the mineral. This thin layer is composed by amorphous silica and hydrated silica "permeable" to the transfer of water and ionic chemical constituents. The boundary/interface between the initial mineral and the silica layer is characterized by a high concentration jump of chemical products at the nanoscale and some specific interfacial dissolution/precipitation processes.In this study, the results of numerical simulations dealing with different mechanisms of silicate and carbonate dissolution/precipitation reactions and integrating interfacial processes will be discussed. The application of this approach to silica precipitation is based on laboratory experiments and it highlights the significant role of the "titration" surface induced by surface complexation reactions in the determination of the kinetics of precipitation.

Summary of events and geotechnical factors leading to decommissioning of the Strategic Petroleum Reserve (SPR) facility at Weeks Island, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neal, J.T.; Bauer, S.J.; Ehgartner, B.L.

1996-10-01

A sinkhole discovered over the edge of the Strategic Petroleum Reserve storage facility at Weeks Island salt dome, Louisiana, led to decommissioning the site during 1995--1998, following extensive diagnostics in 1994. The sinkhole resulted from mine-induced fractures in the salt which took may years to develop, eventually causing fresh water to leak into the storage chamber and dissolve the overlying salt, thus causing overburden collapse into the void. Prior to initiating the oil removal, a freeze wall was constructed at depth around the sinkhole in 1995 to prevent water inflow; a freeze plug will remain in place until the minemore » is backfilled with brine in 1997--8, and stability is reached. Residual oil will be removed; environmental monitoring has been initiated and will continue until the facility is completely plugged and abandoned, and environmental surety is achieved.« less

Status Report on Laboratory Testing and International Collaborations in Salt.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuhlman, Kristopher L.; Matteo, Edward N.; Hadgu, Teklu

This report is a summary of the international collaboration and laboratory work funded by the US Department of Energy Office of Nuclear Energy Spent Fuel and Waste Science & Technology (SFWST) as part of the Sandia National Laboratories Salt R&D work package. This report satisfies milestone levelfour milestone M4SF-17SN010303014. Several stand-alone sections make up this summary report, each completed by the participants. The first two sections discuss international collaborations on geomechanical benchmarking exercises (WEIMOS) and bedded salt investigations (KOSINA), while the last three sections discuss laboratory work conducted on brucite solubility in brine, dissolution of borosilicate glass into brine, andmore » partitioning of fission products into salt phases.« less

Multistage 8.2 kyr event revealed through high-resolution XRF core scanning of Cuban sinkhole sediments

NASA Astrophysics Data System (ADS)

Peros, Matthew; Collins, Shawn; G'Meiner, Anna Agosta; Reinhardt, Eduard; Pupo, Felipe Matos

2017-07-01

We use sediments from a flooded sinkhole (Cenote Jennifer) in northern Cuba to provide new, well-dated, high-resolution evidence for the 8.2 kyr event. From 7600 to 8700 cal yr B.P. the sinkhole contained shallow, low-salinity water, which supported a marsh dominated by cattail and grass. Peaks in Cl and Br—occurring at 8150, 8200, and 8250 cal yr B.P.—are attributable to increased evaporation due to regional drying associated with the 8.2 kyr event. The three peaks in these elements also closely correspond to the greyscale record from the Cariaco Basin, indicative of increased upwelling in the southern Caribbean Sea at this time, supporting the notion of a multistage 8.2 kyr event. Our work provides new data that help to clarify the initiation, behavior, and impacts of the 8.2 kyr event in the northern tropics.

Karst landforms revealed at various scales using LiDAR and UAV in semi-arid Brazil: Consideration on karstification processes and methodological constraints

NASA Astrophysics Data System (ADS)

Silva, Orildo L.; Bezerra, Francisco H. R.; Maia, Rubson P.; Cazarin, Caroline L.

2017-10-01

This paper analyzes different types of karst landforms and their relationships with fracture systems, sedimentary bedding, and fluvial processes. We mapped karst features in the Cretaceous carbonates of the Jandaíra Formation in the Potiguar Basin, Brazil. We used high-resolution digital elevation models acquired using LiDAR and aerial orthophotographs acquired using an unmanned aerial vehicle (UAV). We grouped and described karst evolution according to scale and degree of karstification. These degrees of karst evolution are coeval. Fractures are opened by dissolution, forming vertical fluid conduits, whereas coeval dissolution occurs along horizontal layers. This conduit system acts as pathways for water flow. The enlargement of conduits contributes to the collapse of blocks in sinkholes and expansion of caves during an intermediate degree of karstification. Propagation of dissolution can cause the coalescence of sinkholes and the capture of small streams. Fluvial processes dominate karst dissolution at an advanced degree of karstification. Comparisons with previously published ground-penetrating radar (GPR), borehole and seismic surveys in sedimentary basins indicate that these structures can be partially preserved during burial.

The impact of droughts and climate change on sinkhole occurrence. A case study from the evaporite karst of the Fluvia Valley, NE Spain.

PubMed

Linares, Rogelio; Roqué, Carles; Gutiérrez, Francisco; Zarroca, Mario; Carbonel, Domingo; Bach, Joan; Fabregat, Ivan

2017-02-01

This work introduces the concept that sinkhole frequency in some karst settings increases during drought periods. This conception is tested in a sector of the Fluvia River valley in NE Spain, where subsidence phenomena is related to the karstification of folded Eocene evaporite formations. In the discharge areas, the evaporites behave as confined aquifers affected by hypogene karstification caused by aggressive artesian flows coming form an underlying carbonate aquifer. A sinkhole inventory with chronological data has been constructed, revealing temporal clusters. Those clusters show a good correlation with drought periods, as revealed by precipitation, river discharge and piezometric data. This temporal association is particularly obvious for the last and current drought starting in 1998, which is the most intense of the record period (1940-present). Climatic projections based on recent studies foresee an intensification of the droughts in this sector of NE Spain, which could be accompanied by the enhancement of the sinkhole hazard and the associated risks. Copyright © 2016 Elsevier B.V. All rights reserved.

Anodic Dissolution of Al Current Collectors in Unconventional Solvents for High Voltage Electrochemical Double-Layer Capacitors.

PubMed

Krummacher, Jakob; Heß, Lars-Henning; Balducci, Andrea

2017-09-04

This study investigated the anodic dissolution of Al current collectors in unconventional electrolytes for high voltage electrochemical double-layer capacitors (EDLCs) containing adiponitrile (ADN), 3-cyanopropionic acid methyl ester (CPAME), 2-methyl-glutaronitrile (2-MGN) as solvent, and tetraethylammonium tetrafluoroborate (Et 4 NBF 4 ) and tetraethylammonium bis(trifluoromethanesulfonyl)imide (Et 4 NTFSI) as conductive salts. To have a comparison with the state-of-the-art electrolytes, the same salts were also used in combination with acetonitrile (ACN). The chemical-physical properties of the electrolytes were investigated. Furthermore, their impact on the anodic dissolution of Al was analyzed in detail as well as the influence of this process on the performance of high voltage EDLCs. The results of this study indicated that in the case of Et 4 NBF 4 -based electrolytes, the use of an alternative solvent is very beneficial for the realization of stable devices. When Et 4 NTFSI is used, the reduced solubility of the complex Al(TFSI) 3 appears to be the key for the realization of advanced electrolytes. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mechanism of dissolution of a lithium salt in an electrolytic solvent in a lithium ion secondary battery: a direct ab initio molecular dynamics (AIMD) study.

PubMed

Tachikawa, Hiroto

2014-06-06

The mechanism of dissolution of the Li(+) ion in an electrolytic solvent is investigated by the direct ab initio molecular dynamics (AIMD) method. Lithium fluoroborate (Li(+)BF4(-)) and ethylene carbonate (EC) are examined as the origin of the Li(+) ion and the solvent molecule, respectively. This salt is widely utilized as the electrolyte in the lithium ion secondary battery. The binding of EC to the Li(+) moiety of the Li(+)BF4(-) salt is exothermic, and the binding energies at the CAM-B3LYP/6-311++G(d,p) level for n=1, 2, 3, and 4, where n is the number of EC molecules binding to the Li(+) ion, (EC)n(Li(+)BF4(-)), are calculated to be 91.5, 89.8, 87.2, and 84.0 kcal mol(-1) (per EC molecule), respectively. The intermolecular distances between Li(+) and the F atom of BF4(-) are elongated: 1.773 Å (n=0), 1.820 Å (n=1), 1.974 Å (n=2), 1.942 Å (n=3), and 4.156 Å (n=4). The atomic bond populations between Li(+) and the F atom for n=0, 1, 2, 3, and 4 are 0.202, 0.186, 0.150, 0.038, and 0.0, respectively. These results indicate that the interaction of Li(+) with BF4(-) becomes weaker as the number of EC molecules is increased. The direct AIMD calculation for n=4 shows that EC reacts spontaneously with (EC)3(Li(+)BF4(-)) and the Li(+) ion is stripped from the salt. The following substitution reaction takes place: EC+(EC)3(Li(+)BF4(-))→(EC)4Li(+)-(BF4(-)). The reaction mechanism is discussed on the basis of the theoretical results. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Liquid Salt as Green Solvent: A Novel Eco-Friendly Technique to Enhance Solubility and Stability of Poorly Soluble Drugs

NASA Astrophysics Data System (ADS)

Patel, Anant A.

As a result of tremendous efforts in past few decades, various techniques have been developed in order to resolve solubility issues associated with class II and IV drugs, However, majority of these techniques offer benefits associated with certain drawbacks; majorly including low drug loading, physical instability on storage and excessive use of environmentally challenging organic solvents. Hence, current effort was to develop an eco-friendly technique using liquid salt as green solvent, which can offer improvement in dissolution while maintaining long term stability. The liquid salt formulations (LSF) of poorly soluble model drugs ibuprofen, gemfibrozil and indomethacin were developed using 1-Ethyl-3-methylimidazolium ethyl sulfate (EMIM ES) as a non-toxic and environmentally friendly alternate to organic solvents. Liquid medications containing clear solutions of drug, EMIM ES and polysorbate 20, were adsorbed onto porous carrier Neusilin US2 to form free flowing powder. The LSF demonstrated greater rate and extent of dissolution compared to crystalline drugs. The dissolution data revealed that more than 80% drug release from LSF within 20 mins compared to less than 18% release from pure drugs. As high as 70% w/w liquid loading was achieved while maintaining good flowability and compressibility. In addition, the LSF samples exposed to high temperature and high humidity i.e. 40°C/80% RH for 8 weeks, demonstrated excellent physical stability without any signs of precipitation or crystallization. As most desirable form of administration is tablet, the developed liquid salt formulations were transformed into tablets using design of experiment approach by Design Expert Software. The tablet formulation composition and critical parameter were optimized using Box-Behnken Design. This innovative liquid salt formulation technique offered improvement in dissolution rate and extent as well as contributed to excellent physical stability on storage. Moreover, this formulation

Sinkhole risk analysis from the point of view of a public building insurance, the case of Vaud County (Switzerland)

NASA Astrophysics Data System (ADS)

Nicolet, P.; Choffet, M.; Jaboyedoff, M.; Lauraux, B.; Lance, J.-. L.; Champod, E.

2012-04-01

Natural hazards are being mapped in the Vaud County and sinkhole hazard is part of this process. An preliminary hazard map has already been made based on the sinkholes occurrences and on several other parameters such as rocks types, proximity of major faults and closed basins. The detailed hazard map essentially based on the occurrence of sinkholes is in process. This map will influence the landuse planning. Presently, the public building insurance is covering the damage costs due to all natural hazards that are being mapped except sinkholes. For the sake of consistency and due to political pressure, the insurance company wants to integrate this phenomenon in its insurance coverage. This study aims to assess the potential damage costs to buildings induced by this decision. Karstic process is active in two regions in the County. The first one, namely the Folded Jura, is composed of Jurassic and Cretaceous Carbonate rocks. The second one, the Prealpine region, is composed of both Carbonate and evaporitic rocks. Even if the cavities in carbonate rocks can cause difficulties during the buildings construction, the karst development in these rocks is relatively slow and, as a result, the expected damage costs to buildings is relatively low. In contrast, the evaporitic rocks are likely to cause significant subsidence or sudden collapses at human scale and thus damage the buildings. Therefore, our study is focused on the region where this rock type occurs. It results that many buildings, i.e. more than 10'000, are concerned according to the preliminary hazard map. However some of these buildings are in zones with very low potential. Based on estimated frequencies of collapsing events and subsidence rates, the potential damage cost is estimated. Furthermore, the number of potential claims is also considered in order to know the expected additional work for the insurance company. Careful attention is also given to the potential development of building zones. In addition, the

The Investigation of a Sinkhole Area in Germany by Near-Surface Active Seismic Tomography

NASA Astrophysics Data System (ADS)

Tschache, S.; Becker, D.; Wadas, S. H.; Polom, U.; Krawczyk, C. M.

2017-12-01

In November 2010, a 30 m wide and 17 m deep sinkhole occurred in a residential area of Schmalkalden, Germany, which fortunately did not harm humans, but led to damage of buildings and property. Subsequent geoscientific investigations showed that the collapse was naturally caused by the subrosion of sulfates in a depth of about 80 m. In 2012, an early warning system was established including 3C borehole geophones deployed in 50 m depth around the backfilled sinkhole. During the acquisition of two shallow 2D shear wave seismic profiles, the signals generated by a micro-vibrator at the surface were additionally recorded by the four borehole geophones of the early warning system and a VSP probe in a fifth borehole. The travel time analysis of the direct arrivals enhanced the understanding of wave propagation in the area. Seismic velocity anomalies were detected and related to structural seismic images of the 2D profiles. Due to the promising first results, the experiment was further extended by distributing vibration points throughout the whole area around the sinkhole. This time, micro-vibrators for P- and S-wave generation were used. The signals were recorded by the borehole geophones and temporary installed seismometers at surface positions close to the boreholes. The travel times and signal attenuations are evaluated to detect potential instable zones. Furthermore, array analyses are performed. The first results reveal features in the active tomography datasets consistent with structures observed in the 2D seismic images. The advantages of the presented method are the low effort and good repeatability due to the permanently installed borehole geophones. It has the potential to determine P-wave and S-wave velocities in 3D. It supports the interpretation of established investigation methods as 2D surface seismics and VSP. In our further research we propose to evaluate the suitability of the method for the time lapse monitoring of changes in the seismic wave

FUSED SALT PROCESS FOR RECOVERY OF VALUES FROM USED NUCLEAR REACTOR FUELS

DOEpatents

Moore, R.H.

1960-08-01

A process is given for recovering plutonium from a neutron-irradiated uranium mass (oxide or alloy) by dissolving the mass in an about equimolar alkali metalaluminum double chloride, adding aluminum metal to the mixture obtained at a temperature of between 260 and 860 deg C, and separating a uranium-containing metal phase and a plutonium-chloride- and fission-product chloridecontaining salt phase. Dissolution can be expedited by passing carbon tetrachloride vapors through the double salt. Separation without reduction of plutonium from neutron- bombarded uranium and that of cerium from uranium are also discussed.

Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI).

PubMed

Nour, Matthew M; Evans, Lisa; Nutt, David; Carhart-Harris, Robin L

2016-01-01

The experience of a compromised sense of "self", termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation. Items were rated using a visual analog scale. Participants answered the questionnaire for experiences with classical psychedelic drugs, cocaine and/or alcohol. They also answered the seven questions from the Mystical Experiences Questionnaire (MEQ) relating to the experience of unity with one's surroundings. Six hundred and ninety-one participants completed the questionnaire, providing data for 1828 drug experiences (1043 psychedelics, 377 cocaine, 408 alcohol). Exploratory factor analysis demonstrated that the eight EDI items loaded exclusively onto a single common factor, which was orthogonal to a second factor comprised of the items relating to ego-inflation (rho = -0.110), demonstrating discriminant validity. The EDI correlated strongly with the MEQ-derived measure of unitive experience (rho = 0.735), demonstrating convergent validity. EDI internal consistency was excellent (Cronbach's alpha 0.93). Three analyses confirmed the specificity of ego-dissolution for experiences occasioned by psychedelic drugs. Firstly, EDI score correlated with drug-dose for psychedelic drugs (rho = 0.371), but not for cocaine (rho = 0.115) or alcohol (rho = -0.055). Secondly, the linear regression line relating the subjective intensity of the experience to ego-dissolution was significantly steeper for psychedelics (unstandardized regression

Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI)

PubMed Central

Nour, Matthew M.; Evans, Lisa; Nutt, David; Carhart-Harris, Robin L.

2016-01-01

Aims: The experience of a compromised sense of “self”, termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. Method: Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation. Items were rated using a visual analog scale. Participants answered the questionnaire for experiences with classical psychedelic drugs, cocaine and/or alcohol. They also answered the seven questions from the Mystical Experiences Questionnaire (MEQ) relating to the experience of unity with one’s surroundings. Results: Six hundred and ninety-one participants completed the questionnaire, providing data for 1828 drug experiences (1043 psychedelics, 377 cocaine, 408 alcohol). Exploratory factor analysis demonstrated that the eight EDI items loaded exclusively onto a single common factor, which was orthogonal to a second factor comprised of the items relating to ego-inflation (rho = −0.110), demonstrating discriminant validity. The EDI correlated strongly with the MEQ-derived measure of unitive experience (rho = 0.735), demonstrating convergent validity. EDI internal consistency was excellent (Cronbach’s alpha 0.93). Three analyses confirmed the specificity of ego-dissolution for experiences occasioned by psychedelic drugs. Firstly, EDI score correlated with drug-dose for psychedelic drugs (rho = 0.371), but not for cocaine (rho = 0.115) or alcohol (rho = −0.055). Secondly, the linear regression line relating the subjective intensity of the experience to ego-dissolution was significantly steeper for psychedelics

Comparison of the physicochemical properties of the N-(2-hydroxyethyl) pyrrolidine, diethylamine and sodium salt forms of diclofenac.

PubMed

O'Connor, K M; Corrigan, O I

2001-07-17

Non steroidal anti-inflammatory agents (NSAIDs) such as diclofenac have very low aqueous solubilities and consequently salt formation may be used to enhance solubility and dissolution rate. In this study, we examined the physicochemical properties of three diclofenac salts, diclofenac sodium (DNa), diclofenac N-(2-hydroxyethyl)pyrrolidine (DHEP) and diclofenac diethylamine (DDEA), and their different solid state forms to determine the influence of salt form on solubility, dissolution rate and membrane transport. The equilibrium solubility of DDEA at 25 degrees C was determined as 33 mM, lower than the solubilities of DHEP (273 mM) and DNa (66 mM) previously reported (Ledwidge and Corrigan, 1998). In addition to the dihydrate form of DHEP previously characterised, monohydrate forms of DHEP and DDEA were identified. Intrinsic dissolution rate studies were used to determine the solubility ratios of the hydrated and anhydrous forms. The monohydrate form of DHEP was found to be 1.8 times less soluble than the anhydrate, whereas DDEA anhydrate was approximately 1.7 times as soluble as the monohydrate form. On investigation of the pH-solubility profile (25 degrees C) of DDEA, appreciable supersaturation (76 mM) relative to the theoretical profile, was detected at the pH(max). This contrasts with values of >800 and 67 mM for DHEP and DNa, respectively. The transport of salt solutions through a porous membrane (Visking) was investigated. A linear relationship between concentration (mM) and rate of transport (mmol/h) was established for DNa and DHEP solutions. The mass transfer coefficient determined for DHEP was lower than that for the other two salts. Nevertheless, the maximum transport rate obtained for DHEP is almost six times higher than that obtained for DDEA.

5 CFR 2634.410 - Dissolution.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Dissolution. 2634.410 Section 2634.410..., QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Qualified Trusts § 2634.410 Dissolution. Within thirty days of dissolution of a qualified trust, the interested party shall file a report of the dissolution...

5 CFR 2634.410 - Dissolution.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Dissolution. 2634.410 Section 2634.410..., QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Qualified Trusts § 2634.410 Dissolution. Within thirty days of dissolution of a qualified trust, the interested party shall file a report of the dissolution...

Sinkhole-like structures as bioproductivity hotspots in the Abrolhos Bank

NASA Astrophysics Data System (ADS)

Cavalcanti, Giselle S.; Gregoracci, Gustavo B.; Longo, Leila de L.; Bastos, Alex C.; Ferreira, Camilo M.; Francini-Filho, Ronaldo B.; Paranhos, Rodolfo; Ghisolfi, Renato D.; Krüger, Ricardo; Güth, Arthur Z.; Sumida, Paulo Y. G.; Bruce, Thiago; Maia-Neto, Oswaldo; de O. Santos, Eidy; Iida, Tetsuya; Moura, Rodrigo L.; Amado-Filho, Gilberto M.; Thompson, Fabiano L.

2013-11-01

We performed a biological survey in the novel system of sinkhole-like structures ("buracas") of the Abrolhos Bank, Brazil. We found dissimilar benthic assemblages and higher nutrient concentration, microbial abundance (and activity) and fish abundance inside the buracas than in the surrounding rhodolith beds. Our results support the view that these cup-shaped structures trap and accumulate organic matter, functioning as productivity hotspots in the mid and outer shelf of the central portion of the Abrolhos Bank shelf, where they aggregate biomass of commercially important fishes. This distinctive system is being increasingly pressured by commercial fisheries and needs urgent management measures such as fishing effort control and representation in the network of Marine Protected Areas (MPAS).

Groundwater flow and potential effects on evaporite dissolution in the Paradox Basin, SE Utah

NASA Astrophysics Data System (ADS)

Reitman, N.; Ge, S.; Mueller, K. J.

2012-12-01

A hydrogeologic study was conducted in the portion of the Paradox Basin south of the Needles District of Canyonlands National Park, Utah. Geology of the study area comprises fractured and faulted Paleozoic sandstone, limestone, and shale, which are underlain by evaporite cycles of the Paradox Formation. The evaporite deposits deform and dissolve when they come in contact with groundwater, generating land subsidence, saline groundwater, and salt input to the Colorado River. Active faults in the region slip at a rate of approximately 2 mm/year, likely due to evaporite dissolution. The objective of this study is to better understand groundwater flow and solute transport dynamics and to help determine the rate and timing of subsurface salt dissolution, which is an important control on the salt tectonics in the region. Study methods include hydrologic fieldwork, laboratory tests, and numerical modeling. No groundwater wells exist in the study area. Water samples from springs and seeps were collected throughout the study area. Analysis of total dissolved solids (TDS), stable oxygen (δ18O) and deuterium (δD) isotopes, spring and seep locations, and prior data are used to gain a preliminary understanding of the shallow groundwater flow in the region. Stable isotope ratios of oxygen (18O/16O) and deuterium (D/H) are used to constrain the source of spring water. Measured δ values are compared to predicted δ values for precipitation from WaterIsotopes.org for each sample site. Measured isotopic values range from -14.9 ‰ to -10.7 ‰ for δ18O and -108 ‰ to -78 ‰ for δD. The majority of samples from above 2000 m match predicted isotopic values for precipitation. Most samples taken below 2000 m are lighter than predicted isotopic values for precipitation. The TDS of spring samples measured in the lab show they range from 184 mg/L to 1552 mg/L with the majority of samples between 220 - 430 mg/L. TDS shows a weak correlation (R2 = 0.54) with altitude, where lower TDS

Late Holocene stable carbon and nitrogen isotopic variation of bulk organic matter deposited in Blackwood Sinkhole, Abaco, The Bahamas

NASA Astrophysics Data System (ADS)

Tamalavage, A.; van Hengstum, P. J.; Louchouarn, P.; Fall, P. L.; Donnelly, J. P.

2015-12-01

In the modern climate of the Bahamas, a latitudinal precipitation gradient only allows Pine (Pinus caribaea var. bahamensis) dominated forests to exist on the more mesic (humid) northern islands (Abaco, Andros, New Providence, Grand Bahamas). Previous research suggests that the northern Bahamas underwent dramatic environmental changes in the late Holocene (e.g., waves of human arrival, shifts in terrestrial vegetation and animal extinctions). However, disentangling the timing and relative forcing (climatic vs. anthropogenic) of these changes has proven challenging without high-resolution terrestrial climate records. Recently, a late Holocene decadal to multi-decadal laminated sedimentary record was recovered from Blackwood Sinkhole, on Abaco Island. The bottom of the sinkhole is characterized by anoxic, saline groundwater, while the upper, brackish meteoric lens provides a habitat to fish, algae and other organisms. Here, we present δ13Corg and δ15Norg values of bulk organic matter (OM) taken every cm of the 110 cm core to help elucidate changes in the chemical composition of the source of OM reaching the anoxic sediments of the sinkhole. δ13Corg values change at 812 Cal yrs BP (2s: 931-681 Cal yrs BP, 31.7 cm depth) from -30.5 ± 1.6‰ in the lower 80 cm of the core to -27.6 ± 1.2‰ in the upper 30 cm. There is a synchronous change from more enriched δ15N values, 3.7 ± 1.1‰, in the lower portion of the core, to lower δ15N values (1.9 ± .5‰), in the upper portion of the core. A pollen-based reconstruction of terrestrial vegetation from the same core indicates that these isotopic shifts are concomitant with a shift from a dominance of Arecaceae (Palms) and tropical dry hardwoods below 30 cm, to Pinus and Conocarpus predominance above 30 cm. These results indicate that the source of sedimentary OM deposited into the sinkhole changed coherently with regional landscape change. Biomarker analyses will be used to further identify the role of autochthonous

Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis.

PubMed

Stupák, Ivan; Pavloková, Sylvie; Vysloužil, Jakub; Dohnal, Jiří; Čulen, Martin

2017-11-23

Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatus-Golem v2. We designed eight compartments of uniform size but different inner geometry. The dissolution performance of the compartments was tested using immediate release caffeine tablets and evaluated by standard statistical methods and principal component analysis. Based on two phases of dissolution testing (using 250 and 100 mL of dissolution medium), we selected two compartment types yielding the highest measurement reproducibility. We also confirmed a statistically ssignificant effect of agitation rate and dissolution volume on the extent of drug dissolved and measurement reproducibility.

Solutal convection induced by dissolution. Influence on erosion dynamics and interface shaping.

NASA Astrophysics Data System (ADS)

Berhanu, Michael; Philippi, Julien; Cohen, Caroline; Derr, Julien; Courrech du Pont, Sylvain

2017-04-01

Rock fractures invaded by a water flow, are often subjected to dissolution, which let grow and evolve the initial fracture network, by evacuating the eroded minerals under a solute form. In the case of fast kinetic of dissolution, local erosion rate is set by the advection of the solute. The erosion velocity decreases indeed with the solute concentration at the interface and vanishes when this concentration reaches the saturation value. Even in absence of an imposed or external flow, advection can drive the dissolution, when buoyancy effects due to gravity induce a solutal convection flow, which controls the erosive dynamics and modifies the shape of the dissolving interface. Here, we investigate using model experiments with fast dissolving materials and numerical simulations in simplified situations, solutal convection induced by dissolution. Results are interpreted regarding a linear stability analysis of the corresponding solutal Rayleigh-Benard instability. A dissolving surface is suspended above a water height, initially at rest. In a first step, solute flux is transported through a growing diffusion layer. Then after an onset time, once the layer exceeds critical width, convection flow starts under the form of falling plumes. A dynamic equilibrium results in average from births and deaths of intermittent plumes, setting the size of the solute concentration boundary layer at the interface and thus the erosion velocity. Solutal convection can also induce a pattern on the dissolving interface. We show experimentally with suspended and inclined blocks of salt and sugar, that in a linear stage, the first wavelength of the dissolution pattern corresponds to the wavelength of the convection instability. Then pattern evolves to more complex shapes due to non-linear interactions between the flow and the eroded interface. More generally, we inquire what are the conditions to observe a such solutal convection instability in geological situations and if the properties of

Hydroregime prediction models for ephemeral groundwater-driven sinkhole wetlands: a planning tool for climate change and amphibian conservation

Treesearch

C. H. Greenberg; S. Goodrick; J. D. Austin; B. R. Parresol

2015-01-01

Hydroregimes of ephemeral wetlands affect reproductive success of many amphibian species and are sensitive to altered weather patterns associated with climate change.We used 17 years of weekly temperature, precipitation, and waterdepth measurements for eight small, ephemeral, groundwaterdriven sinkhole wetlands in Florida sandhills to develop a hydroregime predictive...

Climatology of salt transitions and implications for stone weathering.

PubMed

Grossi, C M; Brimblecombe, P; Menéndez, B; Benavente, D; Harris, I; Déqué, M

2011-06-01

This work introduces the notion of salt climatology. It shows how climate affects salt thermodynamic and the potential to relate long-term salt damage to climate types. It mainly focuses on specific sites in Western Europe, which include some cities in France and Peninsular Spain. Salt damage was parameterised using the number of dissolution-crystallisation events for unhydrated (sodium chloride) and hydrated (sodium sulphate) systems. These phase transitions have been calculated using daily temperature and relative humidity from observation meteorological data and Climate Change models' output (HadCM3 and ARPEGE). Comparing the number of transitions with meteorological seasonal data allowed us to develop techniques to estimate the frequency of salt transitions based on the local climatology. Results show that it is possible to associate the Köppen-Geiger climate types with potential salt weathering. Temperate fully humid climates seem to offer the highest potential for salt damage and possible higher number of transitions in summer. Climates with dry summers tend to show a lesser frequency of transitions in summer. The analysis of temperature, precipitation and relative output from Climate Change models suggests changes in the Köppen-Geiger climate types and changes in the patterns of salt damage. For instance, West Europe areas with a fully humid climate may change to a more Mediterranean like or dry climates, and consequently the seasonality of different salt transitions. The accuracy and reliability of the projections might be improved by simultaneously running multiple climate models (ensembles). Copyright © 2011 Elsevier B.V. All rights reserved.

Rapid releases of metal salts and nutrients following the deposition of volcanic ash into aqueous environments

NASA Astrophysics Data System (ADS)

Jones, Morgan T.; Gislason, Sigurður R.

2008-08-01

Deposition of volcanic ash into aqueous environments leads to dissolution of adsorbed metal salts and aerosols, increasing the bioavailability of key nutrients. Volcanogenic fertilization events could increase marine primary productivity, leading to a drawdown of atmospheric CO 2. Here we conduct flow-through experiments on unhydrated volcanic ash samples from a variety of locations and sources, measuring the concentrations and fluxes of elements into de-ionized water and two contrasting ocean surface waters. Comparisons of element fluxes show that dissolution of adsorbed surface salts and aerosols dominates over glass dissolution, even in sustained low pH conditions. These surface ash-leachates appear unstable, decaying in situ even if kept unhydrated. Volcanic ash from recent eruptions is shown to have a large fertilization potential in both fresh and saline water. Fluorine concentrations are integral to bulk dissolution rates and samples with high F concentrations display elevated fluxes of some nutrients, particularly Fe, Si, and P. Bio-limiting micronutrients are released in large quantities, suggesting that subsequent biological growth will be limited by macronutrient availability. Importantly, acidification of surface waters and high fluxes of toxic elements highlights the potential of volcanic ash-leachates to poison aqueous environments. In particular, large pH changes can cause undersaturation of CaCO 3 polymorphs, damaging populations of calcifying organisms. Deposition of volcanic ash can both fertilize and/or poison aqueous environments, causing significant changes to surface water chemistry and biogeochemical cycles.

Effects of magnetic fields on dissolution of arthritis causing crystals

NASA Astrophysics Data System (ADS)

Takeuchi, Y.; Iwasaka, M.

2015-05-01

The number of gout patients has rapidly increased because of excess alcohol and salt intake. The agent responsible for gout is the monosodium urate (MSU) crystal. MSU crystals are found in blood and consist of uric acid and sodium. As a substitute for drug dosing or excessive water intake, physical stimulation by magnetic fields represents a new medical treatment for gout. In this study, we investigated the effects of a magnetic field on the dissolution of a MSU crystal suspension. The white MSU crystal suspension was dissolved in an alkaline solution. We measured the light transmission of the MSU crystal suspension by a transmitted light measuring system. The magnetic field was generated by a horizontal electromagnet (maximum field strength was 500 mT). The MSU crystal suspension that dissolved during the application of a magnetic field of 500 mT clearly had a higher dissolution rate when compared with the control sample. We postulate that the alkali solution promoted penetration upon diamagnetic rotation and this magnetic field orienting is because of the pronounced diamagnetic susceptibility anisotropy of the MSU crystal. The results indicate that magnetic fields represent an effective gout treatment approach.

Theoretical Analysis of Drug Dissolution: I. Solubility and Intrinsic Dissolution Rate.

PubMed

Shekunov, Boris; Montgomery, Eda Ross

2016-09-01

The first-principles approach presented in this work combines surface kinetics and convective diffusion modeling applied to compounds with pH-dependent solubility and in different dissolution media. This analysis is based on experimental data available for approximately 100 compounds of pharmaceutical interest. Overall, there is a linear relationship between the drug solubility and intrinsic dissolution rate expressed through the total kinetic coefficient of dissolution and dimensionless numbers defining the mass transfer regime. The contribution of surface kinetics appears to be significant constituting on average ∼20% resistance to the dissolution flux in the compendial rotating disk apparatus at 100 rpm. The surface kinetics contribution becomes more dominant under conditions of fast laminar or turbulent flows or in cases when the surface kinetic coefficient may decrease as a function of solution composition or pH. Limitations of the well-known convective diffusion equation for rotating disk by Levich are examined using direct computational modeling with simultaneous dissociation and acid-base reactions in which intrinsic dissolution rate is strongly dependent on pH profile and solution ionic strength. It is shown that concept of diffusion boundary layer does not strictly apply for reacting/interacting species and that thin-film diffusion models cannot be used quantitatively in general case. Copyright © 2016. Published by Elsevier Inc.

Effects of polyphosphates and fluoride on hydroxyapatite dissolution: A pH-stat investigation.

PubMed

do Amaral, Jackeline Gallo; Delbem, Alberto Carlos Botazzo; Pessan, Juliano Pelim; Manarelli, Michele Mauricio; Barbour, Michele E

2016-03-01

This study investigated the immediate and sustained effect of sodium trimetaphosphate (TMP) and sodium hexametaphosphate (HMP) associated or not with fluoride (F) on hydroxyapatite (HA) dissolution using an erosion-like model, considering as well as the influence of salivary coating. Baseline dissolution rates were determined for HA discs using a pH-stat system. In the first set of experiments, HA discs were treated with 1100μgF/mL, 1% or 8% of HMP, 1% or 8% of TMP and 1100μgF/mL associated with 1% or 8% of HMP or TMP, totaling 9 groups (n=8). In a second phase, HA discs were kept in pooled human saliva at 37°C for 2h before treatment with deionised water and 1100μgF/mL associated with 1% or 8% of HMP or TMP, totaling 5 groups (n=8). The post-treatment dissolution rate was determined from three consecutive 30-min assays. Data were analysed using 2 and 3-way ANOVA followed by Fisher and Holm-Sidak methods, respectively (α=0.05). All test solutions promoted reduction in HA dissolution rate when compared to baseline control in the first post-treatment run (p<0.001). However, a synergistic effect was only observed between fluoride and 1% HMP. Moreover, the duration of inhibitory effect was greater when 8% HMP and 1 or 8% HMP associated with F were assessed (p<0.001). The presence of salivary coating led to higher protection for all groups when compared to discs without coating (p<0.001). The reduction of HA dissolution rate, as well as the duration of this effect were influenced by fluoride, type and concentration of phosphate salt and the presence of a salivary coating. Copyright © 2015 Elsevier Ltd. All rights reserved.

Density Fluctuation in Aqueous Solutions and Molecular Origin of Salting-Out Effect for CO 2

DOE PAGES

Ho, Tuan Anh; Ilgen, Anastasia

2017-10-26

Using molecular dynamics simulation, we studied the density fluctuations and cavity formation probabilities in aqueous solutions and their effect on the hydration of CO 2. With increasing salt concentration, we report an increased probability of observing a larger than the average number of species in the probe volume. Our energetic analyses indicate that the van der Waals and electrostatic interactions between CO 2 and aqueous solutions become more favorable with increasing salt concentration, favoring the solubility of CO 2 (salting in). However, due to the decreasing number of cavities forming when salt concentration is increased, the solubility of CO 2more » decreases. The formation of cavities was found to be the primary control on the dissolution of gas, and is responsible for the observed CO 2 salting-out effect. Finally, our results provide the fundamental understanding of the density fluctuation in aqueous solutions and the molecular origin of the salting-out effect for real gas.« less

Density Fluctuation in Aqueous Solutions and Molecular Origin of Salting-Out Effect for CO 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ho, Tuan Anh; Ilgen, Anastasia

Using molecular dynamics simulation, we studied the density fluctuations and cavity formation probabilities in aqueous solutions and their effect on the hydration of CO 2. With increasing salt concentration, we report an increased probability of observing a larger than the average number of species in the probe volume. Our energetic analyses indicate that the van der Waals and electrostatic interactions between CO 2 and aqueous solutions become more favorable with increasing salt concentration, favoring the solubility of CO 2 (salting in). However, due to the decreasing number of cavities forming when salt concentration is increased, the solubility of CO 2more » decreases. The formation of cavities was found to be the primary control on the dissolution of gas, and is responsible for the observed CO 2 salting-out effect. Finally, our results provide the fundamental understanding of the density fluctuation in aqueous solutions and the molecular origin of the salting-out effect for real gas.« less

The Kinetics of Dissolution Revisited

NASA Astrophysics Data System (ADS)

Antonel, Paula S.; Hoijemberg, Pablo A.; Maiante, Leandro M.; Lagorio, M. Gabriela

2003-09-01

An experiment analyzing the kinetics of dissolution of a solid with cylindrical geometry in water is presented. The dissolution process is followed by measuring the solid mass and its size parameters (thickness and diameter) as a function of time. It is verified that the dissolution rate follows the Nernst model. Data treatment is compared with the dissolution of a spherical solid previously described. Kinetics, diffusion concepts, and polynomial fitting of experimental data are combined in this simple experiment.

Oral Sustained Release of a Hydrophilic Drug Using the Lauryl Sulfate Salt/Complex.

PubMed

Kasashima, Yuuki; Yoshihara, Keiichi; Yasuji, Takehiko; Sako, Kazuhiro; Uchida, Shinya; Namiki, Noriyuki

2016-01-01

The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt/complex for sustained release of a hydrophilic drug at various physiological pH levels. Mirabegron is a hydrophilic drug that exhibits pH-dependent solubility. Sodium lauryl sulfate (SLS) bound to mirabegron in a stoichiometric manner. The formation of the LS salt/complex significantly reduced mirabegron solubility and helped achieve sustained release of mirabegron over a wide range of pH levels. In addition to SLS, other additives containing a sulfate group formed salts/complexes with mirabegron and reduced its solubility at different pH levels. Furthermore, octyl sulfate (OS), myristyl sulfate (MS), and cetyl sulfate (CS) salts/complexes, which contain alkyl chains of different lengths, showed a lower solubility than mirabegron and promoted sustained release of mirabegron. The rank order of solubility and dissolution rate were as follows: OS salt/complex>LS salt/complex>MS salt/complex>CS salt/complex, which corresponded to the rank of alkyl chain lengths. We conclude that the presence of a sulfate group and the length of the alkyl chain are key factors of the LS salt/complex for sustained release of a hydrophilic drug at various physiological pH levels.

12 CFR 546.4 - Voluntary dissolution.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Voluntary dissolution. 546.4 Section 546.4 Banks... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 546.4 Voluntary dissolution. A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 546.4 - Voluntary dissolution.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Voluntary dissolution. 546.4 Section 546.4 Banks... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 546.4 Voluntary dissolution. A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 546.4 - Voluntary dissolution.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Voluntary dissolution. 546.4 Section 546.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 546.4 Voluntary dissolution. A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 146.4 - Voluntary dissolution.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Voluntary dissolution. 146.4 Section 146.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.4 Voluntary dissolution. (a) A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 146.4 - Voluntary dissolution.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Voluntary dissolution. 146.4 Section 146.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.4 Voluntary dissolution. (a) A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 546.4 - Voluntary dissolution.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Voluntary dissolution. 546.4 Section 546.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 546.4 Voluntary dissolution. A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 546.4 - Voluntary dissolution.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Voluntary dissolution. 546.4 Section 546.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 546.4 Voluntary dissolution. A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

12 CFR 146.4 - Voluntary dissolution.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Voluntary dissolution. 146.4 Section 146.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.4 Voluntary dissolution. (a) A Federal savings association's board of directors may propose a plan for dissolution of the association. The plan...

Bridging the Gap Between In Vitro Dissolution and the Time Course of Ibuprofen-Mediating Pain Relief.

PubMed

Cristofoletti, Rodrigo; Dressman, Jennifer B

2016-12-01

In vitro-in vivo extrapolation techniques combined with physiologically based pharmacokinetic models represent a feasible approach to establishing links between critical quality attributes and the time course of drug concentrations in vivo. By further integrating the results with pharmacodynamic (PD) models, scientists can also explore the time course of drug effect. The aim of this study was to assess whether differences in dissolution rates would affect the onset, magnitude, and duration of the time course of ibuprofen-mediating pain relief. An integrated in vitro-in vivo extrapolation-physiologically based pharmacokinetic/PD model was used to simulate pharmacokinetic and PD profiles for ibuprofen free acid (IBU-H) and its salts. Two elements of the pharmacokinetic profile, the peak of exposure (C max ) and the time to peak concentration (T max ), were sensitive to dissolution rate, whereas only 1 element of the pharmacodynamic profile was affected, namely the onset of drug action. The C max differences between IBU-H and its salts seem to be mitigated in the (hypothetical) effect compartment because of the concurrent distribution and elimination processes. Furthermore, the predicted maximum concentration in the effect compartment exceeded the EC 80 value, which marks the plateau phase of the PD concentration-response curve, regardless of whether IBU-H or its salts were administered. Understanding the target site distribution kinetics and the potential nonlinearities between exposure and response will assist in setting criteria that are more scientifically based for the demonstration of therapeutic equivalence. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Dissolution of solid dosage form. II. Equations for the dissolution of nondisintegrating tablet under the sink condition.

PubMed

Yonezawa, Y; Shirakura, K; Otsuka, A; Sunada, H

1991-03-01

An equation for dissolution from the whole surface of a nondisintegrating single component tablet under the sink condition was derived. Also, equations for several dissolution manners of the tablet under the sink condition were derived in the postulation of the dominant dissolution rate constant which determines the dissolution manner. The applicability or validity of these equations were examined by the dissolution measurements with nondisintegrating single component tablets. About one-tenth the amount of the amount needed to saturate the solution was used to prepare a tablet, and dissolution measurements were carried out with the tablet whose flat or side surface was masked with an adhesive tape in accordance with the conditions for derivation of equations. Among the derived equations, dissolution from the whole surface of a tablet was expressed by a form similar to the cube root law equation for particles. Hence, a single component tablet compressed by the use of a suitable amount was thought to behave like a single crystal. Also, equations derived for several dissolution manners were thought to be applicable for the dissolution of a nonspherical particle and crystal concerning the crystal's habit and its dissolution property, and the extended applicability was examined by converting the crystal into a simplified or idealized form, i.e., rectangle or plate.

A review of stormwater management in karst

USDA-ARS?s Scientific Manuscript database

Stormwater management can be a challenge in any environment, but it is especially difficult in karst terrain. The characteristic dissolution of bedrock creates depressions in topography as well as voids in the subsurface, resulting in problems such as collapse sinkhole development, groundwater cont...

Effect of sodium lauryl sulfate in dissolution media on dissolution of hard gelatin capsule shells.

PubMed

Zhao, Fang; Malayev, Vyacheslav; Rao, Venkatramana; Hussain, Munir

2004-01-01

Sodium lauryl sulfate (SLS) is a commonly used surfactant in dissolution media for poorly water soluble drugs. However, it has occasionally been observed that SLS negatively impacts the dissolution of drug products formulated in gelatin capsules. This study investigated the effect of SLS on the dissolution of hard gelatin capsule shells. The USP paddle method was used with online UV monitoring at 214 nm (peptide bond). Empty size #0 capsule shells were held to the bottom of the dissolution vessel by magnetic three-prong sinkers. SLS significantly slowed down the dissolution of gelatin shells at pH < 5. Visually, the gelatin shells transformed into some less-soluble precipitate under these conditions. This precipitate was found to contain a higher sulfur content than the gelatin control sample by elemental analysis, indicating that SLS is part of the precipitate. Additionally, the slowdown of capsule shell dissolution was shown to be dependent on the SLS concentration and the ionic strength of the media. SLS interacts with gelatin to form a less-soluble precipitate at pH < 5. The use of SLS in dissolution media at acidic pH should be carefully evaluated for gelatin capsule products.

A method of mapping sinkhole susceptibility using a geographic information system : a case study for interstates in the karst counties of Virginia.

DOT National Transportation Integrated Search

2015-02-01

This study proposes the use of a geographic information system (GIS) to create a susceptibility map, pinpointing : regions in the karst counties of Virginia, in particular, along interstates, most susceptible to future sinkhole : development, determi...

Theoretical study of the influence of chemical reactions and physical parameters on the convective dissolution of CO2 in aqueous solutions

NASA Astrophysics Data System (ADS)

Loodts, Vanessa; Rongy, Laurence; De Wit, Anne

2014-05-01

Subsurface carbon sequestration has emerged as a promising solution to the problem of increasing atmospheric carbon dioxide (CO2) levels. How does the efficiency of such a sequestration process depend on the physical and chemical characteristics of the storage site? This question is emblematic of the need to better understand the dynamics of CO2 in subsurface formations, and in particular, the properties of the convective dissolution of CO2 in the salt water of aquifers. This dissolution is known to improve the safety of the sequestration by reducing the risks of leaks of CO2 to the atmosphere. Buoyancy-driven convection makes this dissolution faster by transporting dissolved CO2 further away from the interface. Indeed, upon injection, the less dense CO2 phase rises above the aqueous layer where it starts to dissolve. The dissolved CO2 increases the density of the aqueous solution, thereby creating a layer of denser CO2-rich solution above less dense solution. This unstable density gradient in the gravity field is at the origin of convection. In this framework, we theoretically investigate the effect of CO2 pressure, salt concentration, temperature, and chemical reactions on the dissolution-driven convection of CO2 in aqueous solutions. On the basis of a linear stability analysis, we assess the stability of the time-dependent density profiles developing when CO2 dissolves in an aqueous layer below it. We predict that increasing CO2 pressure destabilizes the system with regard to buoyancy-driven convection, because it increases the density gradient at the origin of the instability. By contrast, increasing salt concentration or temperature stabilizes the system via effects on CO2 solubility, solutal expansion coefficient, diffusion coefficient and on the viscosity and density of the solution. We also show that a reaction of CO2 with chemical species dissolved in the aqueous solution can either enhance or decrease the amplitude of the convective dissolution compared

pH-Dependent Solubility and Dissolution Behavior of Carvedilol--Case Example of a Weakly Basic BCS Class II Drug.

PubMed

Hamed, Rania; Awadallah, Areeg; Sunoqrot, Suhair; Tarawneh, Ola; Nazzal, Sami; AlBaraghthi, Tamadur; Al Sayyad, Jihan; Abbas, Aiman

2016-04-01

The objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized by low solubility and high permeability, using carvedilol, a weak base with a pK a value of 7.8, as a model drug. A series of solubility and in vitro dissolution studies was carried out using media that simulate the gastric and intestinal fluids and cover the physiological pH range of the GI from 1.2 to 7.8. The effect of ionic strength, buffer capacity, and buffer species of the dissolution media on the solubility and dissolution behavior of carvedilol was also investigated. The study revealed that carvedilol exhibited a typical weak base pH-dependent solubility profile with a high solubility at low pH (545.1-2591.4 μg/mL within the pH range 1.2-5.0) and low solubility at high pH (5.8-51.9 μg/mL within the pH range 6.5-7.8). The dissolution behavior of carvedilol was consistent with the solubility results, where carvedilol release was complete (95.8-98.2% released within 60 min) in media simulating the gastric fluid (pH 1.2-5.0) and relatively low (15.9-86.2% released within 240 min) in media simulating the intestinal fluid (pH 6.5-7.8). It was found that the buffer species of the dissolution media may influence the solubility and consequently the percentage of carvedilol released by forming carvedilol salts of varying solubilities. Carvedilol solubility and dissolution decreased with increasing ionic strength, while lowering the buffer capacity resulted in a decrease in carvedilol solubility and dissolution rate.

Clinopyroxene dissolution in basaltic melt

NASA Astrophysics Data System (ADS)

Chen, Yang; Zhang, Youxue

2009-10-01

The history of magmatic systems may be inferred from reactions between mantle xenoliths and host basalt if the thermodynamics and kinetics of the reactions are quantified. To study diffusive and convective clinopyroxene dissolution in silicate melts, diffusive clinopyroxene dissolution experiments were conducted at 0.47-1.90 GPa and 1509-1790 K in a piston-cylinder apparatus. Clinopyroxene saturation is found to be roughly determined by MgO and CaO content. The effective binary diffusivities, DMgO and DCaO, and the interface melt saturation condition, C0MgO×C0CaO, are extracted from the experiments. DMgO and DCaO show Arrhenian dependence on temperature. The pressure dependence is small and not resolved within 0.47-1.90 GPa. C0MgO×C0CaO in the interface melt increases with increasing temperature, but decreases with increasing pressure. Convective clinopyroxene dissolution, where the convection is driven by the density difference between the crystal and melt, is modeled using the diffusivities and interface melt saturation condition. Previous studies showed that the convective dissolution rate depends on the thermodynamics, kinetics and fluid dynamics of the system. Comparing our results for clinopyroxene dissolution to results from a previous study on convective olivine dissolution shows that the kinetic and fluid dynamic aspects of the two minerals are quite similar. However, the thermodynamics of clinopyroxene dissolution depends more strongly on the degree of superheating and composition of the host melt than that of olivine dissolution. The models for clinopyroxene and olivine dissolution are tested against literature experiments on mineral-melt interaction. They are then applied to previously proposed reactions between Hawaii basalts and mantle minerals, mid-ocean ridge basalts and mantle minerals, and xenoliths digestion in a basalt at Kuandian, Northeast China.

Mathematical modeling of drug dissolution.

PubMed

Siepmann, J; Siepmann, F

2013-08-30

The dissolution of a drug administered in the solid state is a pre-requisite for efficient subsequent transport within the human body. This is because only dissolved drug molecules/ions/atoms are able to diffuse, e.g. through living tissue. Thus, generally major barriers, including the mucosa of the gastro intestinal tract, can only be crossed after dissolution. Consequently, the process of dissolution is of fundamental importance for the bioavailability and, hence, therapeutic efficacy of various pharmaco-treatments. Poor aqueous solubility and/or very low dissolution rates potentially lead to insufficient availability at the site of action and, hence, failure of the treatment in vivo, despite a potentially ideal chemical structure of the drug to interact with its target site. Different physical phenomena are involved in the process of drug dissolution in an aqueous body fluid, namely the wetting of the particle's surface, breakdown of solid state bonds, solvation, diffusion through the liquid unstirred boundary layer surrounding the particle as well as convection in the surrounding bulk fluid. Appropriate mathematical equations can be used to quantify these mass transport steps, and more or less complex theories can be developed to describe the resulting drug dissolution kinetics. This article gives an overview on the current state of the art of modeling drug dissolution and points out the assumptions the different theories are based on. Various practical examples are given in order to illustrate the benefits of such models. This review is not restricted to mathematical theories considering drugs exhibiting poor aqueous solubility and/or low dissolution rates, but also addresses models quantifying drug release from controlled release dosage forms, in which the process of drug dissolution plays a major role. Copyright © 2013 Elsevier B.V. All rights reserved.

25 CFR 11.605 - Dissolution.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Dissolution. 11.605 Section 11.605 Indians BUREAU OF... Domestic Relations § 11.605 Dissolution. (a) The Court of Indian Offenses shall enter a decree of dissolution of marriage if: (1) The court finds that the marriage is irretrievably broken, if the finding is...

25 CFR 11.605 - Dissolution.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Dissolution. 11.605 Section 11.605 Indians BUREAU OF... Domestic Relations § 11.605 Dissolution. (a) The Court of Indian Offenses shall enter a decree of dissolution of marriage if: (1) The court finds that the marriage is irretrievably broken, if the finding is...

25 CFR 11.605 - Dissolution.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Dissolution. 11.605 Section 11.605 Indians BUREAU OF... Domestic Relations § 11.605 Dissolution. (a) The Court of Indian Offenses shall enter a decree of dissolution of marriage if: (1) The court finds that the marriage is irretrievably broken, if the finding is...

25 CFR 11.605 - Dissolution.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Dissolution. 11.605 Section 11.605 Indians BUREAU OF... Domestic Relations § 11.605 Dissolution. (a) The Court of Indian Offenses shall enter a decree of dissolution of marriage if: (1) The court finds that the marriage is irretrievably broken, if the finding is...

Structural control in sinkhole development and speleogenesis: a case study from the High Murge karst landscape (Apulia, Italy)

NASA Astrophysics Data System (ADS)

Pepe, M.; Parise, M.

2012-04-01

The Murge plateau is the main karst sector of Apulia, an almost entirely carbonate region of SE Italy. It can be, in turn, subdivided into two sectors: High Murge, the inland plateau, where remnants of an ancient tropical karst are still recognizable; and Low Murge, closer to the Adriatic Sea, with smoother karst morphologies and landforms, but, at the same time, hosting some of the longest underground karst system in the region (Parise, 1998, 2006). Even though showing low energy relief, the landscape of High Murge is very articulated when examined at greater detail, with several interesting karst features. Among these, sinkholes are definitely the most significant, showing a variety of typologies and, at the same time, a high frequency, both as individual features and as coalescent landforms, giving origin to more complex depressions (Parise, 2011). Previous studies carried out in the High Murge through morphometric analysis of the main sinkholes identified on the 1:25,000 scale topographic maps from the Italian Army Geographical Institute indicated their likely genesis in a low relief cockpit karst (Sauro, 1991). Over such landscape, developed in Upper Tertiary, a hydrographic pattern was superimposed, that partly opened some of the depressions, also dismantling sectors of the karst relief and producing talus deposits (Caldara & Ciaranfi, 1988). In the present work we take into consideration the southern countryside of Ruvo di Puglia. Choice of the area, which extends over 15 km2, was dictated by presence of a high number of sinkholes, and of several important caves with prevailing vertical development, including the deepest pit ever explored in Apulia (Grave della Ferratella, depth - 320 m). The cave is nowadays not accessible, due to clogging caused by land use changes during the 80's. Based upon extensive field surveys and interpretation of multi-year aerial photographs (time range 1955-2003), integrated by surveying in selected caves, the main hydro

Continuous plutonium dissolution apparatus

DOEpatents

Meyer, F.G.; Tesitor, C.N.

1974-02-26

This invention is concerned with continuous dissolution of metals such as plutonium. A high normality acid mixture is fed into a boiler vessel, vaporized, and subsequently condensed as a low normality acid mixture. The mixture is then conveyed to a dissolution vessel and contacted with the plutonium metal to dissolve the plutonium in the dissolution vessel, reacting therewith forming plutonium nitrate. The reaction products are then conveyed to the mixing vessel and maintained soluble by the high normality acid, with separation and removal of the desired constituent. (Official Gazette)

Simulating Salt Movement and Transformation using a Coupled Reactive Transport Model in Variably-Saturated Groundwater Systems

NASA Astrophysics Data System (ADS)

Tavakoli Kivi, S.; Bailey, R. T.; Gates, T.

2016-12-01

Salinization is one of the major concerns in irrigated agricultural landscapes. Increasing salinity concentrations are due principally to evaporative concentration; dissolution of salts from weathered minerals and bedrock; and a high water table that results from excessive irrigation, canal seepage, and a lack of efficient drainage systems; leading to decreasing crop yield. High groundwater salinity loading to nearby river systems also impacts downstream areas, with saline river water diverted for application on irrigated fields. In this study, a solute transport model coupled with equilibrium chemistry reactions has been developed to simulate transport of individual salt ions in regional-scale aquifer systems and thereby investigate strategies for salinity remediation. The physically-based numerical model is based on the UZF-RT3D variably-saturated, multi-species groundwater reactive transport modeling code, and accounts for advection, dispersion, carbon and nitrogen cycling, oxidation-reduction reactions, and salt ion equilibrium chemistry reactions such as complexation, ion exchange, and precipitation/dissolution. Each major salt ion (sulfate, chloride, bicarbonate, calcium, sodium, magnesium, potassium) is included. The model has been tested against measured soil salinity at a small scale (soil profile) and against soil salinity, groundwater salinity, and groundwater salinity loading to surface water at the regional scale (500 km2) in the Lower Arkansas River Valley (LARV) in southeastern Colorado, an area acutely affected by salinization for many decades and greatly influenced by gypsum deposits. Preliminary results of using the model in scenario analysis suggest that increasing irrigation efficiency, sealing earthen canals, and rotational fallowing of land can decrease the groundwater salt load to the Arkansas River by 50 to 70% and substantially lower soil salinity in the root zone.

Combining piracetam and lithium salts: ionic co-crystals and co-drugs?

PubMed

Braga, Dario; Grepioni, Fabrizia; Maini, Lucia; Capucci, Davide; Nanna, Saverio; Wouters, Johan; Aerts, Luc; Quéré, Luc

2012-08-25

Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.

Effects of Pump Pulsation on Hydrodynamic Properties and Dissolution Profiles in Flow-Through Dissolution Systems (USP 4).

PubMed

Yoshida, Hiroyuki; Kuwana, Akemi; Shibata, Hiroko; Izutsu, Ken-Ichi; Goda, Yukihiro

2016-06-01

To clarify the effects of pump pulsation and flow-through cell (FTC) dissolution system settings on the hydrodynamic properties and dissolution profiles of model formulations. Two FTC systems with different cell temperature control mechanisms were used. Particle image velocimetry (PIV) was used to analyze the hydrodynamic properties of test solutions in the flow-through dissolution test cell. Two pulsation pumps (semi-sine, full-sine) and a non-pulsatile pump were used to study the effects of varied flows on the dissolution profiles of United States Pharmacopeia standard tablets. PIV analysis showed periodic changes in the aligned upward fluid flow throughout the dissolution cell that was designed to reduce the temperature gradient during pump pulsation (0.5 s/pulse). The maximum instantaneous flow from the semi-sine pump was higher than that of the full-sine pump under all conditions. The flow from the semi-sine wave pump showed faster dissolution of salicylic acid and prednisone tablets than those from other pumps. The semi-sine wave pump flow showed similar dissolution profiles in the two FTC systems. Variations in instantaneous fluid flow caused by pump pulsation that meets the requirements of pharmacopoeias are a factor that affects the dissolution profiles of tablets in FTC systems.

The effects of ion identity and ionic strength on the dissolution rate of a gibbsitic bauxite

NASA Astrophysics Data System (ADS)

Mogollón, José Luis; Pérez-Diaz, Alberto; Lo Monaco, Salvador

2000-03-01

The influence of cation and anion identity and concentration, on the far from equilibrium dissolution rate of gibbsite, was studied at 298°K. Input solutions, with initial pH = 3.5 and variable salt type and concentration, were flowed at different rates, through columns packed with a unconsolidated gibbsitic bauxite from Los Pijigüaos-Venezuela ore deposit. It was observed cations Na +, K +, Mg 2+ and Ca2+ have no influence on the far from equilibrium dissolution rate. Anions have two different effects: concentration increases of monovalent anions (Cl -, NO 3- and ClO 4-) causes a decrease in the rate, as a function of [anion] (-0.11 ± 0.01); and increases of sulfate concentration causes an increase in the rate as a function of [SO 4=] (0.4 ± 0.1). According to our calculations, these two effects have a remarkable influence upon the lifetime of gibbsite under weathering conditions. Based on Transition State Theory, it is proposed the experimental observations are due to an electrostatic effect on the activated complex (AC ♯) of the gibbsite dissolution reaction. For this AC ♯ the product of the charge of the involved chemical entities is negative. When SO 4= participates in the AC ♯ the product of the charges switches to positive and therefore, the electrostatic interaction increase the dissolution rate. The dissolution rates are independent of the solution saturation degree below ΔGr = - 0.74 kcal/mol. It is inferred that the critical ΔGr is a constant of the solid, not affected by the solution characteristics, e.g., pH, ionic strength, cation and anion identities.

Dynamics of Phase Transitions in a Snow Mass Containing Water-Soluble Salt Particles

NASA Astrophysics Data System (ADS)

Zelenko, V. L.; Heifets, L. I.; Orlov, Yu. N.; Voskresenskiy, N. M.

2018-07-01

A macrokinetic approach is used to describe the dynamics of phase transitions in a snow mass containing water-soluble salt particles. Equations are derived that describe the rate of salt granule dissolution and the change in the phase composition and temperature of a snow mass under the conditions of heat transfer with an isothermal surface. An experimental setup that models the change in the state of a snow mass placed on an isothermal surface is created to verify theoretical conclusions. Experimental observations of the change in temperature of the snow mass are compared to theoretical calculations. The mathematical model that is developed can be used to predict the state of a snow mass on roads treated with a deicing agent, or to analyze the state of snow masses containing water-soluble salt inclusions and resting on mountain slopes.

Salt disproportionation: A material science perspective.

PubMed

Thakral, Naveen K; Kelly, Ron C

2017-03-30

While screening the counter-ions for salt selection for an active pharmaceutical substance, there is often an uncertainty about disproportionation of the salt and hence physical stability of the final product formulation to provide adequate shelf life. Several examples of disproportionation reactions are reviewed to explain the concepts of pHmax, microenvironmental pH, and buffering capacity of excipients and APIs to gain mechanistic understanding of disproportionation reaction. Miscellaneous factors responsible for disproportionation are examined. In addition to the dissolution failure due to the formation of less soluble unionized form, various implications of the disproportionation are evaluated with specific examples. During lead optimization and early stages of development, when only a limited amount of material is available, use of predictive tools like mathematical models and model free kinetics to rank order the various counter-ions are discussed in detail. Finally, analytical methods and mitigation strategies are discussed to prevent the disproportionation by detecting it during early stages of drug development. Copyright © 2017 Elsevier B.V. All rights reserved.

Stirring effect on kaolinite dissolution rate

NASA Astrophysics Data System (ADS)

Metz, Volker; Ganor, Jiwchar

2001-10-01

Experiments were carried out measuring kaolinite dissolution rates using stirred and nonstirred flow-through reactors at pHs 2 to 4 and temperatures of 25°C, 50°C, and 70°C. The results show an increase of kaolinite dissolution rate with increasing stirring speed. The stirring effect is reversible, i.e., as the stirring slows down the dissolution rate decreases. The effect of stirring speed on kaolinite dissolution rate is higher at 25°C than at 50°C and 70°C and at pH 4 than at pHs 2 and 3. It is suggested that fine kaolinite particles are formed as a result of stirring-induced spalling or abrasion of kaolinite. These very fine particles have an increased ratio of reactive surface area to specific surface area, which results in enhancement of kaolinite dissolution rate. A balance between production and dissolution of the fine particles explains both the reversibility and the temperature and pH dependence of the stirring effect. Since the stirring effect on kaolinite dissolution rate varies with temperature and pH, measurement of kinetic parameters such as activation energy may be influenced by stirring. Therefore, standard use of nonagitated reaction vessels for kinetic experiments of mineral dissolution and precipitation is recommended, at least for slow reactions that are surface controlled.

Late Cenozoic regional collapse due to evaporite flow and Dissolution in the Carbondale Collapse Center, West-Central Colorado

USGS Publications Warehouse

Kirkham, R.M.; Streufert, R.K.; Budahn, J.R.; Kunk, Michael J.; Perry, W.J.

2001-01-01

Dissolution and flow of Pennsylvanian evaporitic rocks in west-central Colorado created the Carbondale Collapse Center, a 450 mi2 structural depression with about 4,000 ft of vertical collapse during the late Cenozoic. This paper describes evidence of collapse in the lower Roaring Fork River valley. Both the lateral extent and amount of vertical collapse is constrained by deformed upper Cenozoic volcanic rocks that have been correlated using field mapping, 40Ar/39Ar geochronology, geochemistry, and paleomagnetism. The Carbondale Collapse Center is one of at least two contiguous areas that have experienced major evaporite tectonism during the late Cenozoic. Historic sinkholes, deformed Holocene deposits, and modern high-salinity loads in the rivers and thermal springs indicate the collapse process continues today. Flow of evaporitic rocks is an important element in the collapse process, and during initial stages of collapse it was probably the primary causative mechanism. Dissolution, however, is the ultimate means by which evaporite is removed from the collapse area. As the Roaring Fork River began to rapidly down-cut through a broad volcanic plateau during the late Miocene, the underlying evaporite beds were subjected to differential overburden pressures. The evaporitic rocks flowed from beneath the upland areas where overburden pressures remained high, toward the Roaring Fork River Valley where the pressures were much lower. Along the valley the evaporitic rocks rose upward, sometimes as diapirs, forming or enhancing a valley anticline in bedrock and locally upwarping Pleistocene terraces. Wherever the evaporites encountered relatively fresh ground water, they were dissolved, forming underground voids into which overlying bedrock and surficial deposits subsided. The saline ground water eventually discharged to streams and rivers through thermal springs and by seepage into alluvial aquifers.

Discriminative Dissolution Method for Benzoyl Metronidazole Oral Suspension.

PubMed

da Silva, Aline Santos; da Rosa Silva, Carlos Eduardo; Paula, Fávero Reisdorfer; da Silva, Fabiana Ernestina Barcellos

2016-06-01

A dissolution method for benzoyl metronidazole (BMZ) oral suspensions was developed and validated using a high-performance liquid chromatography (HPLC) method. After determination of sink conditions, dissolution profiles were evaluated using different dissolution media and agitation speeds. The sample insertion mode in dissolution media was also evaluated. The best conditions were obtained using a paddle, 50 rpm stirring speed, simulated gastric fluid (without pepsin) as the dissolution medium, and sample insertion by a syringe. These conditions were suitable for providing sink conditions and discriminatory power between different formulations. Through the tested conditions, the results can be considered specific, linear, precise, accurate, and robust. The dissolution profiles of five samples were compared using the similarity factor (f 2) and dissolution efficiency. The dissolution kinetics were evaluated and described by the Weibull model. Whereas there is no monograph for this pharmaceutical formulation, the dissolution method proposed can be considered suitable for quality control and dissolution profile comparison of different commercial formulations.

Geologic characterization report for the Paradox Basin Study Region, Utah Study Areas. Volume 6: Salt Valley

NASA Astrophysics Data System (ADS)

1984-12-01

Surface landforms in the Salt Valley Area are generally a function of the Salt Valley anticline and are characterized by parallel and subparallel cuestaform ridges and hogbacks and flat valley floors. The most prominent structure in the Area is the Salt Valley anticline. Erosion resulting from the Tertiary uplift of the Colorado Plateau led to salt dissolution and subsequent collapse along the crest of the anticline. Continued erosion removed the collapse material, forming an axial valley along the crest of the anticline. Paleozoic rocks beneath the salt bearing Paradox Formation consist of limestone, dolomite, sandstone, siltstone and shale. The salt beds of the Paradox formation occur in distinct cycles separated by an interbed sequence of anhydrite, carbonate, and clastic rocks. The Paradox Formation is overlain by Pennsylvanian limestone; Permian sandstone; and Mesozoic sandstone, mudstone, conglomerate and shale. No earthquakes have been reported in the area during the period of the historic record and contemporary seismicity appears to be diffusely distributed, of low level and small magnitude. The upper unit includes the Permian strata and upper Honaker trail formation.

Dissolution kinetics of soluble nondisintegrating disks.

PubMed

de Blaey, C J; van der Graaff, H

1977-12-01

An equation describing the isotropical dissolution of soluble nondisintegrating disks was developed. It was equivalent to the cube root law only if the height and diameter of the disk were equal. The dissolution kinetics of sodium chloride disks were examined, using a beaker equipped with a centrifugal stirrer as the dissolution chamber. The fit of the experimental data to the cube root law had a coefficient of variation of about 4-5%. It was demonstrated statistically that a fit to a square root of mass versus time relation was significantly better. With increasing porosity, the dissolution process proceeded faster than predicted on the basis of the diffusion-convection model. An explanation is proposed by assuming an increased effective dissolution surface.

Dissolution of minerals with rough surfaces

NASA Astrophysics Data System (ADS)

de Assis, Thiago A.; Aarão Reis, Fábio D. A.

2018-05-01

We study dissolution of minerals with initial rough surfaces using kinetic Monte Carlo simulations and a scaling approach. We consider a simple cubic lattice structure, a thermally activated rate of detachment of a molecule (site), and rough surface configurations produced by fractional Brownian motion algorithm. First we revisit the problem of dissolution of initial flat surfaces, in which the dissolution rate rF reaches an approximately constant value at short times and is controlled by detachment of step edge sites. For initial rough surfaces, the dissolution rate r at short times is much larger than rF ; after dissolution of some hundreds of molecular layers, r decreases by some orders of magnitude across several time decades. Meanwhile, the surface evolves through configurations of decreasing energy, beginning with dissolution of isolated sites, then formation of terraces with disordered boundaries, their growth, and final smoothing. A crossover time to a smooth configuration is defined when r = 1.5rF ; the surface retreat at the crossover is approximately 3 times the initial roughness and is temperature-independent, while the crossover time is proportional to the initial roughness and is controlled by step-edge site detachment. The initial dissolution process is described by the so-called rough rates, which are measured for fixed ratios between the surface retreat and the initial roughness. The temperature dependence of the rough rates indicates control by kink site detachment; in general, it suggests that rough rates are controlled by the weakest microscopic bonds during the nucleation and formation of the lowest energy configurations of the crystalline surface. Our results are related to recent laboratory studies which show enhanced dissolution in polished calcite surfaces. In the application to calcite dissolution in alkaline environment, the minimal values of recently measured dissolution rate spectra give rF ∼10-9 mol/(m2 s), and the calculated rate

25 CFR 11.606 - Dissolution proceedings.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Dissolution proceedings. 11.606 Section 11.606 Indians... ORDER CODE Domestic Relations § 11.606 Dissolution proceedings. (a) Either or both parties to the marriage may initiate dissolution proceedings. (b) If a proceeding is commenced by one of the parties, the...

25 CFR 11.606 - Dissolution proceedings.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Dissolution proceedings. 11.606 Section 11.606 Indians... ORDER CODE Domestic Relations § 11.606 Dissolution proceedings. (a) Either or both parties to the marriage may initiate dissolution proceedings. (b) If a proceeding is commenced by one of the parties, the...

25 CFR 11.606 - Dissolution proceedings.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Dissolution proceedings. 11.606 Section 11.606 Indians... ORDER CODE Domestic Relations § 11.606 Dissolution proceedings. (a) Either or both parties to the marriage may initiate dissolution proceedings. (b) If a proceeding is commenced by one of the parties, the...

25 CFR 11.606 - Dissolution proceedings.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Dissolution proceedings. 11.606 Section 11.606 Indians... ORDER CODE Domestic Relations § 11.606 Dissolution proceedings. (a) Either or both parties to the marriage may initiate dissolution proceedings. (b) If a proceeding is commenced by one of the parties, the...

The effect of formulation additives on in vitro dissolution-absorption profile and in vivo bioavailability of telmisartan from brand and generic formulations.

PubMed

Borbás, Enikő; Nagy, Zsombor K; Nagy, Brigitta; Balogh, Attila; Farkas, Balázs; Tsinman, Oksana; Tsinman, Konstantin; Sinkó, Bálint

2018-03-01

In this study, brand and four generic formulations of telmisartan, an antihypertensive drug, were used in in vitro simultaneous dissolution-absorption, investigating the effect of different formulation additives on dissolution and on absorption through an artificial membrane. The in vitro test was found to be sensitive enough to show even small differences between brand and generic formulations caused by the use of different excipients. By only changing the type of filler from sorbitol to mannitol in the formulation, the flux through the membrane was reduced by approximately 10%. Changing the salt forming agent as well resulted in approximately 20% of flux reduction compared to the brand formulation. This significant difference was clearly shown in the published in vivo results as well. The use of additional lactose monohydrate in the formulation also leads to approximately 10% reduction in flux. The results show that by changing excipients, the dissolution of telmisartan was not altered significantly, but the flux through the membrane was found to be significantly changed. These results pointed out the limitations of traditional USP dissolution tests and emphasized the importance of simultaneously measuring dissolution and absorption, which allows the complex effect of formulation excipients on both processes to be measured. Moreover, the in vivo predictive power of the simultaneous dissolution-absorption test was demonstrated by comparing the in vitro fluxes to in vivo bioequivalence study results. Copyright © 2018 Elsevier B.V. All rights reserved.

Investigation of the Dissolution Profile of Gliclazide Modified-Release Tablets Using Different Apparatuses and Dissolution Conditions.

PubMed

Skripnik, K K S; Riekes, M K; Pezzini, B R; Cardoso, S G; Stulzer, H K

2017-07-01

In the absence of an official dissolution method for modified-release tablets of gliclazide, dissolution parameters, such as apparatuses (1, 2, and 3), rotation speeds, pH, and composition of the dissolution medium were investigated. The results show that although the drug presents a pH-mediated solubility (pH 7.0 > 6.8 > 6.4 > 6.0 > 5.5 > 4.5), the in vitro release of the studied tablets was not dependent on this parameter, despite of the apparatus tested. On the other hand, the rotation speed demonstrated a greater influence (100 rpm >50 rpm). Using similar hydrodynamic conditions, the three different apparatuses were compared in pH 6.8 and provided the following trend: apparatus 1 at 100 rpm >2 at 50 rpm ≈3 at 10 dpm. As a complete, but slow release is expected from modified-release formulations, apparatus 2, in phosphate buffer pH 6.8 and 100 rpm, were selected as the optimized dissolution method. In comparison to apparatus 1 under the same conditions, the paddle avoids the stickiness of formulation excipients at the mesh of the basket, which could prejudice the release of gliclazide. Results obtained with biorelevant medium through the developed dissolution method were similar to the buffer solution pH 6.8. The application of the optimized method as a quality control test between two different brands of gliclazide modified-release tablets showed that both dissolution profiles were considered similar by the similarity factor (f2 = 51.8). The investigation of these dissolution profiles indicated a dissolution kinetic following first-order model.

Low temperature dissolution flowsheet for Pu metal

DOE PAGES

Daniel, Jr., William E.; Almond, Philip M.; Rudisill, Tracy S.

2017-06-30

The Savannah River National Laboratory was requested to develop a Pu metal dissolution flowsheet at two reduced temperature ranges for implementation in the Savannah River Site H-Canyon facility. The dissolution and H 2 generation rates during Pu metal dissolution were investigated using a dissolving solution at ambient temperature (20–30°C) and for an intermediate temperature of 50–60°C. The Pu metal dissolution rate measured at 57°C was approximately 20 times slower than at boiling (112–116°C). As a result, the dissolution rate at ambient temperature (24°C) was approximately 80 times slower than the dissolution rate at boiling. Hydrogen concentrations were less than detectablemore » (<0.1 vol%).« less

The role of sandstone in the development of an Ozark karst system, south-central Missouri

USGS Publications Warehouse

Orndorff, R.C.; Weary, D.J.; Harrison, R.W.

2006-01-01

Cave, spring, and sinkhole development in the Ozarks of south-central Missouri is placed in a geologic framework through detailed geologic mapping. Geologic mapping shows that initial dissolution and inception of cave development is concentrated just beneath sandstone beds within Upper Cambrian and Lower Ordovician dolostone. Although rocks of the Ozarks have systematic and pervasive vertical joints, the development of karst conduits is controlled by bedding planes and stratigraphic variability. In the Salem Plateau of south-central Missouri, sinkholes occur in the lower part of the Ordovician Roubidoux Formation, where sinkholes are rimmed with and contain sandstone that has collapsed into voids in the underlying Ordovician Gasconade Dolomite. Cave diving by the Ozark Cave Diving Alliance into Alley Spring, a large (average flow 3.7 m3/s) spring along the Jacks Fork in the Ozark National Scenic Riverways, shows that although the spring discharges from the middle part of the Gasconade, the source of water is a cave passage just beneath the Gunter Sandstone Member of the Gasconade Dolomite. Artesian conditions cause the upward movement of groundwater from cavernous dolostone beneath the sandstone aquitards to the large springs. We hypothesize that sandstone, which is largely impermeable due to silica cementation, acts as a confining unit where hydraulic pressure, combined with mixing of water of differing chemistry, increases dissolution in the underlying dolostone beds. ?? 2006 Geological Society of America.

High-resolution seismic reflection survey near SPR surface collapse feature at Weeks Island, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, R.D.; Xia, J.; Harding, R.S. Jr.

1994-12-31

Shallow high resolution 2-D and 3-D seismic reflection techniques are assisting in the subsurface delineation of a surface collapse feature (sinkhole) at Weeks Island, Louisiana. Seismic reflection surveys were conducted in March 1994. Data from walkaway noise tests were used to assist selection of field recording parameters. The top of the salt dome is about 180 ft below ground surface at the sinkhole. The water table is an estimated 90 ft below the ground surface. A single coherent reflection was consistently recorded across the entire area of the survey, although stacking velocity and spectral content of the event varied. Onmore » the basis of observed travel times and stacking velocities, the coherent reflection event appears to originate above the top of the salt, possibly at or near the water table. Identification of this reflector will be made form borehole investigations currently planned for the sinkhole site. A depression or time sag in this reflection event is clearly evident in both the 2-D and 3-D seismic data in the immediate vicinity of the sinkhole. The time sag appears to be related to the subsurface structure of the reflector and not to near surface topography or velocity effects. Elsewhere in the survey area, observed changes in reflection travel times and wavelet character appear to be related to subsurface geologic structure. These seismic observations may assist in predicting where future sinkholes will develop after they have been tied to borehole data collected at the site.« less

Hydrologic environment of the Silurian salt deposits in parts of Michigan, Ohio, and New York

USGS Publications Warehouse

Norris, Stanley E.

1978-01-01

The aggregate thickness of evaporites (salt, gypsum, and anhydrite) in the Silurian Salina sequence in Michigan exceeds 1200 feet in areas near the periphery of the Michigan basin, where the salt beds are less than 3000 feet below land surface. In northeast Ohio the aggregate thickness of salt beds is as much as 200 feet in places, and in western New York it is more than 500 feet, where th beds are less than 3000 feet deep. The salt-bearing rocks dip regionally on the order of 50 feet per mile; those in Michigan dip toward the center of the Michigan basin, and those in Ohio and New York, in the Appalachian basin, dip generally southward. The rocks in both basins thicken downdip. Minor folds and faults occur in the salt-bearing rocks in all three states. Some of this defrmation has been attenuated or absorbed bo the salt beds. Occuring near the middle of thick sedimentary sequences, the salt beds are bounded aboe and below by beds containing water having dissolved-solids concentrations several times that seawter. The brines occur commonly in discrete zones of high permeability at specific places in the stratigraphic sequence. In northeast Ohio two prominent brine zones are recognized by the driller, the Devonian Oriskany Sandstone, or 'first water' zone, above the Salina Formation, and the Newburg or 'second water' zone below the Salina. In each aquifer there is a vertical component of hydraulic head, but little brine probably moves through the salt beds because their permeability is extremely low. Also, ther is little evidence of dissolution of the salt in areas distant from the outcrop, suggesting that if brine does move through the salt, movement is at a slow enough rate so that, in combination with the saturated or near-saturated condition of the water, it precludes significant dissolution. Principal brine movement is probably in the permeable zones in the direction of the hydraulic gradient. Two areas in Michigan and one area each in Ohio and New York appear

Investigation of sinkhole areas in Germany using 2D shear wave reflection seismics and zero-offset VSP

NASA Astrophysics Data System (ADS)

Tschache, Saskia; Wadas, Sonja; Polom, Ulrich; Krawczyk, Charlotte M.

2017-04-01

Sinkholes pose a serious geohazard for humans and infrastructure in populated areas. The Junior Research Group Subrosion within the Leibniz Institute for Applied Geophysics and the joint project SIMULTAN work on the multi-scale investigation of subrosion processes in the subsurface, which cause natural sinkholes. In two case studies in sinkhole areas of Thuringia in Germany, we applied 2D shear wave reflection seismics using SH-waves with the aim to detect suitable parameters for the characterisation of critical zones. This method has the potential to image near-surface collapse and faulting structures in improved resolution compared to P-wave surveys resulting from the shorter wavelength of shear waves. Additionally, the shear wave velocity field derived by NMO velocity analysis is a basis to calculate further physical parameters, as e.g. the dynamic shear modulus. In both investigation areas, vertical seismic profiles (VSP) were acquired by generating P- and SH-waves (6 component VSP) directly next to a borehole equipped with a 3C downhole sensor. They provide shear and compressional wave velocity profiles, which are used to improve the 2D shear wave velocity field from surface seismics, to perform a depth calibration of the seismic image and to calculate the Vp/Vs ratio. The signals in the VSP data are analysed with respect to changes in polarisation and attenuation with depth and/or azimuth. The VSP data reveal low shear wave velocities of 200-300 m/s in rock layers known to be heavily affected by subrosion and confirm the low velocities calculated from the surface seismic data. A discrepancy of the shear wave velocities is observed in other intervals probably due to unsymmetrical travel paths in the surface seismics. In some VSP data dominant conversion of the direct SH-wave to P-wave is observed that is assumed to be caused by an increased presence of cavities. A potential fault distorting the vertical travel paths was detected by abnormal P-wave first

Mechanistic Basis of Cocrystal Dissolution Advantage.

PubMed

Cao, Fengjuan; Amidon, Gordon L; Rodríguez-Hornedo, Naír; Amidon, Gregory E

2018-01-01

Current interest in cocrystal development resides in the advantages that the cocrystal may have in solubility and dissolution compared with the parent drug. This work provides a mechanistic analysis and comparison of the dissolution behavior of carbamazepine (CBZ) and its 2 cocrystals, carbamazepine-saccharin (CBZ-SAC) and carbamazepine-salicylic acid (CBZ-SLC) under the influence of pH and micellar solubilization. A simple mathematical equation is derived based on the mass transport analyses to describe the dissolution advantage of cocrystals. The dissolution advantage is the ratio of the cocrystal flux to drug flux and is defined as the solubility advantage (cocrystal to drug solubility ratio) times the diffusivity advantage (cocrystal to drug diffusivity ratio). In this work, the effective diffusivity of CBZ in the presence of surfactant was determined to be different and less than those of the cocrystals. The higher effective diffusivity of drug from the dissolved cocrystals, the diffusivity advantage, can impart a dissolution advantage to cocrystals with lower solubility than the parent drug while still maintaining thermodynamic stability. Dissolution conditions where cocrystals can display both thermodynamic stability and a dissolution advantage can be obtained from the mass transport models, and this information is useful for both cocrystal selection and formulation development. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Dissolution enhancement of tadalafil by liquisolid technique.

PubMed

Lu, Mei; Xing, Haonan; Yang, Tianzhi; Yu, Jiankun; Yang, Zhen; Sun, Yanping; Ding, Pingtian

2017-02-01

This study aimed to enhance the dissolution of tadalafil, a poorly water-soluble drug by applying liquisolid technique. The effects of two critical formulation variables, namely drug concentration (17.5% and 35%, w/w) and excipients ratio (10, 15 and 20) on dissolution rates were investigated. Pre-compression tests, including particle size distribution, flowability determination, Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and scanning electron microscopy (SEM), were carried out to investigate the mechanism of dissolution enhancement. Tadalafil liquisolid tablets were prepared and their quality control tests, dissolution study, contact angle measurement, Raman mapping, and storage stability test were performed. The results suggested that all the liquisolid tablets exhibited significantly higher dissolution rates than the conventional tablets and pure tadalafil. FT-IR spectrum reflected no drug-excipient interactions. DSC and XRD studies indicated reduction in crystallinity of tadalafil, which was further confirmed by SEM and Raman mapping outcomes. The contact angle measurement demonstrated obvious increase in wetting property. Taken together, the reduction of particle size and crystallinity, and the improvement of wettability were the main mechanisms for the enhanced dissolution rate. No significant changes were observed in drug crystallinity and dissolution behavior after storage based on XRD, SEM and dissolution results.

Seeking sunlight: rapid phototactic motility of filamentous mat-forming cyanobacteria optimize photosynthesis and enhance carbon burial in Lake Huron's submerged sinkholes.

PubMed

Biddanda, Bopaiah A; McMillan, Adam C; Long, Stephen A; Snider, Michael J; Weinke, Anthony D

2015-01-01

We studied the motility of filamentous mat-forming cyanobacteria consisting primarily of Oscillatoria-like cells growing under low-light, low-oxygen, and high-sulfur conditions in Lake Huron's submerged sinkholes using in situ observations, in vitro measurements and time-lapse microscopy. Gliding movement of the cyanobacterial trichomes (100-10,000 μm long filaments, composed of cells ∼10 μm wide and ∼3 μm tall) revealed individual as well as group-coordinated motility. When placed in a petri dish and dispersed in ground water from the sinkhole, filaments re-aggregated into defined colonies within minutes, then dispersed again. Speed of individual filaments increased with temperature from ∼50 μm min(-1) or ∼15 body lengths min(-1) at 10°C to ∼215 μm min(-1) or ∼70 body lengths min(-1) at 35°C - rates that are rapid relative to non-flagellated/ciliated microbes. Filaments exhibited precise and coordinated positive phototaxis toward pinpoints of light and congregated under the light of foil cutouts. Such light-responsive clusters showed an increase in photosynthetic yield - suggesting phototactic motility aids in light acquisition as well as photosynthesis. Once light source was removed, filaments slowly spread out evenly and re-aggregated, demonstrating coordinated movement through inter-filament communication regardless of light. Pebbles and pieces of broken shells placed upon intact mat were quickly covered by vertically motile filaments within hours and became fully buried in the anoxic sediments over 3-4 diurnal cycles - likely facilitating the preservation of falling debris. Coordinated horizontal and vertical filament motility optimize mat cohesion and dynamics, photosynthetic efficiency and sedimentary carbon burial in modern-day sinkhole habitats that resemble the shallow seas in Earth's early history. Analogous cyanobacterial motility may have played a key role in the oxygenation of the planet by optimizing photosynthesis while favoring

Effects of SO42- ions on the corrosion of GH3535 weld joint in FLiNaK molten salt

NASA Astrophysics Data System (ADS)

Zhu, Yasheng; Qiu, Jie; Hou, Juan; Liu, Wenguan; Chen, Huaican; Ai, Hua; Yu, Guojun; Wang, Jianqiang; Zhou, Xingtai

2017-08-01

The present work studied the impact of SO42- ions on the corrosion behaviors of GH3535 weld joint in FLiNaK molten salt. The concentration of SO42- ions in the FLiNaK molten salt was controlled by adjusting the quantity of Na2SO4 added into the salt. Results indicate that the SO42- ions in the FLiNaK salt speed up the corrosion rate remarkably by promoting the dissolution of Cr from the alloy matrix into the salt. With the concentration of SO42- ions in the FLiNaK salt increases from 100 ppm to 1000 ppm, the weight losses and the Cr depletion layer depths of the corroded specimens increase linearly. Even in the case of the heavy corrosion attack caused by the SO42- ions, the corrosion performance is similar between the base zone and fusion zone in the GH3535 weld joint. It is demonstrated that the structural diversity caused by the welding process has little impact on the corrosion performances of GH3535 alloy in FLiNaK molten salt.

Sinkhole susceptibility in carbonate rocks of the Apulian karst (southern Italy)

NASA Astrophysics Data System (ADS)

Di Santo, Antonio; Fazio, Nunzio L.; Fiore, Antonio; Lollino, Piernicola; Luisi, Michele; Miccoli, Maria N.; Pagliarulo, Rosa; Parise, Mario; Perrotti, Michele; Pisano, Luca; Spalluto, Luigi; Vennari, Carmela; Vessia, Giovanna

2016-04-01

Apulia region, the foreland of the southern Italian Apennines, is made up of a 6-7 km-thick succession of Mesozoic shallow-water limestones and dolostones, locally covered by thin and discontinuous Tertiary and Quaternary carbonate and clastic deposits. Due to their long subaerial exposure, the Mesozoic carbonate bedrock recorded the development in the subsurface of a dense network of karst cavities, mostly controlled by tectonic discontinuities. As a result, a strong susceptibility to natural sinkholes has to be recorded in Apulia. In addition, the possibility of occurrence of other problems related to the high number of man-made cavities has to be added in the region. A great variety of different typologies of artificial cavities (mostly excavated in the Plio-Pleistocene soft calcarenites) is actually present, including underground quarries, worship sites, oil mills, civilian settlements, etc. Overall, 2200 natural and 1200 artificial cavities, respectively, have been so far surveyed in Apulia. Following the urban development in the last century in Apulia, many of these cavities lie nowadays below densely populated neighborhoods, roads or communication routes. These conditions are at the origin of the main geomorphological hazard for the human society in Apulia, which requires a careful evaluation, aimed at protecting and safeguarding the human life, and at providing the necessary information for a correct land use planning and management. The importance of the sinkhole hazard is further testified by the worrying increase in the number of events during the last 5-6 years. In response to these situations, joint research activities were started by the Institute of Research for Hydrological Protection of the National Research Council (CNR-IRPI) and the Basin Authority of Apulia, aimed at several goals, that include (but are not limited to) the collection of information on natural and anthropogenic sinkholes in Apulia, the implementation of numerical analyses for

PC based electrolytes with LiDFOB as an alternative salt for lithium-ion batteries

NASA Astrophysics Data System (ADS)

Knight, Brandon M.

Lithium-ion batteries (LIBs) have been greatly sought after as a source of renewable energy storage. LIBs have a wide range of applications including but not limited portable electronic devices, electric vehicles, and power tools. As a direct result of their commercial viability an insatiable hunger for knowledge, advancement within the field of LIBs has been omnipresent for the last two decades. However, there are set backs evident within the LIB field; most notably the limitations of standard electrolyte formulations and LiPF6 lithium salt. The standard primary carbonate of ethylene carbonate (EC) has a very limited operating range due to its innate physical properties, and the LiPF6 salt is known to readily decompose to form HF which can further degrade LIB longevity. The goal of our research is to explore the use of a new primary salt LiDFOB in conjunction with a propylene carbonate based electrolyte to establish a more flexible electrolyte formulation by constructing coin cells and cycling them under various conditions to give a clear understanding of each formulation inherent performance capabilities. Our studies show that 1.2M LiDFOB in 3:7 PC/EMC + 1.5% VC is capable of performing comparably to the standard 1.2M LiPF6 in 3:7 EC/EMC at 25°C and the PC electrolyte also illustrates performance superior to the standard at 55°C. The degradation of lithium manganese spinel electrodes, including LiNi 0.5Mn1.5O4, is an area of great concern within the field of lithium ion batteries (LIBs). Manganese containing cathode materials frequently have problems associated with Mn dissolution which significantly reduces the cycle life of LIB. Thus the stability of the cathode material is paramount to the performance of Mn spinel cathode materials in LIBs. In an effort to gain a better understanding of the stability of LiNi0.5 Mn1.5O4 in common LiPF6/carbonate electrolytes, samples were stored at elevated temperature in the presence of electrolyte. Then after storage both

Phase II modification of the Water Availability Tool for Environmental Resources (WATER) for Kentucky: The sinkhole-drainage process, point-and-click basin delineation, and results of karst test-basin simulations

USGS Publications Warehouse

Taylor, Charles J.; Williamson, Tanja N.; Newson, Jeremy K.; Ulery, Randy L.; Nelson, Hugh L.; Cinotto, Peter J.

2012-01-01

This report describes Phase II modifications made to the Water Availability Tool for Environmental Resources (WATER), which applies the process-based TOPMODEL approach to simulate or predict stream discharge in surface basins in the Commonwealth of Kentucky. The previous (Phase I) version of WATER did not provide a means of identifying sinkhole catchments or accounting for the effects of karst (internal) drainage in a TOPMODEL-simulated basin. In the Phase II version of WATER, sinkhole catchments are automatically identified and delineated as internally drained subbasins, and a modified TOPMODEL approach (called the sinkhole drainage process, or SDP-TOPMODEL) is applied that calculates mean daily discharges for the basin based on summed area-weighted contributions from sinkhole drain-age (SD) areas and non-karstic topographically drained (TD) areas. Results obtained using the SDP-TOPMODEL approach were evaluated for 12 karst test basins located in each of the major karst terrains in Kentucky. Visual comparison of simulated hydrographs and flow-duration curves, along with statistical measures applied to the simulated discharge data (bias, correlation, root mean square error, and Nash-Sutcliffe efficiency coefficients), indicate that the SDPOPMODEL approach provides acceptably accurate estimates of discharge for most flow conditions and typically provides more accurate simulation of stream discharge in karstic basins compared to the standard TOPMODEL approach. Additional programming modifications made to the Phase II version of WATER included implementation of a point-and-click graphical user interface (GUI), which fully automates the delineation of simulation-basin boundaries and improves the speed of input-data processing. The Phase II version of WATER enables the user to select a pour point anywhere on a stream reach of interest, and the program will automatically delineate all upstream areas that contribute drainage to that point. This capability enables

A novel determination of calcite dissolution kinetics in seawater

NASA Astrophysics Data System (ADS)

Subhas, Adam V.; Rollins, Nick E.; Berelson, William M.; Dong, Sijia; Erez, Jonathan; Adkins, Jess F.

2015-12-01

We present a novel determination of the dissolution kinetics of inorganic calcite in seawater. We dissolved 13 C -labeled calcite in unlabeled seawater, and traced the evolving δ13 C composition of the fluid over time to establish dissolution rates. This method provides sensitive determinations of dissolution rate, which we couple with tight constraints on both seawater saturation state and surface area of the dissolving minerals. We have determined dissolution rates for two different abiotic calcite materials and three different grain sizes. Near-equilibrium dissolution rates are highly nonlinear, and are well normalized by geometric surface area, giving an empirical dissolution rate dependence on saturation state (Ω) of: This result substantiates the non-linear response of calcite dissolution to undersaturation. The bulk dissolution rate constant calculated here is in excellent agreement with those determined in far from equilibrium and dilute solution experiments. Plots of dissolution versus undersaturation indicates the presence of at least two dissolution mechanisms, implying a criticality in the calcite-seawater system. Finally, our new rate determination has implications for modeling of pelagic and seafloor dissolution. Nonlinear dissolution kinetics in a simple 1-D lysocline model indicate a possible transition from kinetic to diffusive control with increasing water depth, and also confirm the importance of respiration-driven dissolution in setting the shape of the calcite lysocline.

Application of electrical resistivity tomography techniques for mapping man-made sinkholes

NASA Astrophysics Data System (ADS)

Rey, J.; Martínez, J.; Hidalgo, C.; Dueñas, J.

2012-04-01

The suitability of the geophysical prospecting by electrical resistivity tomography to detect and map man-made subsurface cavities and related sinkholes has been studied in the Linares abandoned mining district (Spain). We have selected for this study four mined sectors constituted of different lithologies: granite and phyllites of Paleozoic age, and Triassic shales and sandstones. In three of these sectors, detail underground topographic surveys were carried out to chart the position and dimensions of the mining voids (galleries and chamber), in order to analyze the resolution of this methodology to characterize these cavities by using different electrode arrays. The results are variable, depending on the depth and diameter of the void, the selected electrode array, the spacing between electrodes, geological complexity and data density. These results also indicate that when the cavity is empty, an anomaly with a steep gradient and high resistivity values is registered, because the air that fills the mining void is dielectric, while when the cavities are filled with fine grain sediments, frequently saturated in water, the electrical resistance is lower. In relation with the three different multi-electrode arrays tested, the Wenner-Schlumberger array has resulted to offer the maximum resolution in all these cases, with lower and more stable values for the RMS than the other arrays. Therefore, this electrode array has been applied in the fourth studied sector, a former mine near the city centre of Linares, in an area of urban expansion in which there are problems of subsidence. Two sets of four electrical tomography profiles have been carried out, perpendicular to each other, and which have allowed reaching depths of research between 30-35 m. This net-array allowed the identification of two shallow anomalies of low resistivity values, interpreted as old mining galleries filled with fine material saturated in water. It also allows detecting two fractures, correlated

Impact of Gut Microbiota-Mediated Bile Acid Metabolism on the Solubilization Capacity of Bile Salt Micelles and Drug Solubility.

PubMed

Enright, Elaine F; Joyce, Susan A; Gahan, Cormac G M; Griffin, Brendan T

2017-04-03

In recent years, the gut microbiome has gained increasing appreciation as a determinant of the health status of the human host. Bile salts that are secreted into the intestine may be biotransformed by enzymes produced by the gut bacteria. To date, bile acid research at the host-microbe interface has primarily been directed toward effects on host metabolism. The aim of this work was to investigate the effect of changes in gut microbial bile acid metabolism on the solubilization capacity of bile salt micelles and consequently intraluminal drug solubility. First, the impact of bile acid metabolism, mediated in vivo by the microbial enzymes bile salt hydrolase (BSH) and 7α-dehydroxylase, on drug solubility was assessed by comparing the solubilization capacity of (a) conjugated vs deconjugated and (b) primary vs secondary bile salts. A series of poorly water-soluble drugs (PWSDs) were selected as model solutes on the basis of an increased tendency to associate with bile micelles. Subsequently, PWSD solubility and dissolution was evaluated in conventional biorelevant simulated intestinal fluid containing host-derived bile acids, as well as in media modified to contain microbial bile acid metabolites. The findings suggest that deconjugation of the bile acid steroidal core, as dictated by BSH activity, influences micellar solubilization capacity for some PWSDs; however, these differences appear to be relatively minor. In contrast, the extent of bile acid hydroxylation, regulated by microbial 7α-dehydroxylase, was found to significantly affect the solubilization capacity of bile salt micelles for all nine drugs studied (p < 0.05). Subsequent investigations in biorelevant media containing either the trihydroxy bile salt sodium taurocholate (TCA) or the dihydroxy bile salt sodium taurodeoxycholate (TDCA) revealed altered drug solubility and dissolution. Observed differences in biorelevant media appeared to be both drug- and amphiphile (bile salt/lecithin) concentration

Crystallization and dissolution of airborne sea-salts on weathered marble in a coastal environment at Delos (Cyclades-Greece)

NASA Astrophysics Data System (ADS)

Chabas, A.; Jeannette, D.; Lefèvre, R. A.

Far from the ground moisture zone, marble remains of Delos archaeological site have undergone an extensive weathering through contour scaling and granular disintegration. Comparison of the analytical results from analytical scanning electron microscopy examination of surface samples of weathered marble and air filtration membranes confirms the atmospheric transport of marine salts and their deposition on stone surface. A laboratory experiment emphasizes the role of these atmospheric salts in the weathering process of marbles in coastal environment.

Dissolution of Uranium Oxides Under Alkaline Oxidizing Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Steven C.; Peper, Shane M.; Douglas, Matthew

2009-11-01

Bench scale experiments were conducted to determine the dissolution characteristics of uranium oxide powders (UO2, U3O8, and UO3) in aqueous peroxide-carbonate solutions. Experimental parameters included H2O2 concentration, carbonate counter cation (NH4+, Na+, K+, and Rb+), and pH. Results indicate the dissolution rate of UO2 in 1 M (NH4)2CO3 increases linearly with peroxide concentration ranging from 0.05 – 2 M. The three uranium oxide powders exhibited different dissolution patterns however, UO3 exhibited prompt complete dissolution. Carbonate counter cation affected the dissolution kinetics. There is minimal impact of solution pH, over the range 8.8 to 10.6, on initial dissolution rate.

Dissolution-resistance of glass-added hydroxyapatite composites

NASA Astrophysics Data System (ADS)

Seo, Dong Seok; Lee, Jong Kook

2009-04-01

Hydroxyapatite (HA) has generated a great deal of interest as a promising implant material. However, its poor mechanical properties induced by severe dissolution in biological milieu limit medical applications and lead to clinical failure. In this study, HA ceramics with 30P2O5-30CaO-40Na2O glass (1.0 wt.% and 2.5 wt.%) were prepared to improve the resistance of monophase HA. The monophase HA sintered body showed microstructural degradation due to grain boundary dissolution in buffered water. However, the dissolution-resistance of HA/glass composites was significantly improved and showed no apparent evidence of dissolution. This suggests that a less soluble glass phase should be placed at grain boundaries to protect HA from dissolution.

Synthesis and Thermodynamic Stability of Ba2B‧B″O6 and Ba3B*B″2O9 Perovskites Using the Molten Salt Method

NASA Astrophysics Data System (ADS)

Meng, Wei; Virkar, Anil V.

1999-12-01

A number of mixed perovskites of the types Ba2B‧B″O6 (BaB‧1/2B″1/2O3) and Ba3B*B″2O9 (BaB*1/3B″2/3O3) where B‧=Gd, La, Nd, Sm, or Y; B″=Nb and B*=Ca were synthesized by a conventional calcination process, as well as by the molten salt method. The former consists of calcining appropriate mixtures of oxide or carbonate precursors in air at elevated temperatures (∼1250°C). The latter method consists of adding appropriate mixtures of oxide or carbonate precursors to a molten salt bath at relatively low temperatures (on the order of 300 to 500°C) so that the requisite compound is formed by dissolution-reprecipitation. X-ray diffraction confirmed the formation of a single-phase perovskite in each case with calcination at 1250°C. In a molten salt bath, however, all except Ba2LaNbO6 and Ba2NdNbO6 formed the perovskite structure. On the contrary, powders of Ba2LaNbO6 and Ba2NdNbO6 formed by a high-temperature calcination process readily decomposed when introduced into the molten salt bath. The formation of the requisite perovskite at a temperature as low as 350°C in a molten salt suggests that: (a) The perovskite is stable at 350°C. (b) The molten salt exhibits sufficient precursor solubility for the dissolution-reprecipitation process to occur in a reasonable time. Similarly, the decomposition of Ba2LaNbO6 and Ba2NdNbO6 in a molten salt bath shows that these materials are thermodynamically unstable at the temperature of the molten salt bath.

Sessile multidroplets and salt droplets under high tangential electric fields

PubMed Central

Xie, Guoxin; He, Feng; Liu, Xiang; Si, Lina; Guo, Dan

2016-01-01

Understanding the interaction behaviors between sessile droplets under imposed high voltages is very important in many practical situations, e.g., microfluidic devices and the degradation/aging problems of outdoor high-power applications. In the present work, the droplet coalescence, the discharge activity and the surface thermal distribution response between sessile multidroplets and chloride salt droplets under high tangential electric fields have been investigated with infrared thermography, high-speed photography and pulse current measurement. Obvious polarity effects on the discharge path direction and the temperature change in the droplets in the initial stage after discharge initiation were observed due to the anodic dissolution of metal ions from the electrode. In the case of sessile aligned multidroplets, the discharge path direction could affect the location of initial droplet coalescence. The smaller unmerged droplet would be drained into the merged large droplet as a result from the pressure difference inside the droplets rather than the asymmetric temperature change due to discharge. The discharge inception voltages and the temperature variations for two salt droplets closely correlated with the ionization degree of the salt, as well as the interfacial electrochemical reactions near the electrodes. Mechanisms of these observed phenomena were discussed. PMID:27121926

Impact of the counterion on the solubility and physicochemical properties of salts of carboxylic acid drugs.

PubMed

David, S E; Timmins, P; Conway, B R

2012-01-01

Salt formation is a widely used approach to improve the physicochemical and solid state properties of an active pharmaceutical ingredient. In order to better understand the relationships between the active drug, the selected counterion and the resultant salt form, crystalline salts were formed using four different carboxylic acid drugs and a closely related series of amine counterions. Thirty-six related crystalline salts were prepared, characterized and the relationship between solubility and dissolution behaviour and other properties of the salt and the counterion studied. Salts of four model acid drugs, gemfibrozil, flurbiprofen, ibuprofen and etodolac were prepared using the counterions butylamine, hexylamine, octylamine, benzylamine, cyclohexylamine, tert-butylamine, 2-amino-2-methylpropan-1-ol, 2-amino-2-methylpropan-1,3-diol and tris(hydroxymethyl)aminomethane. Salt formation was confirmed, the salts were characterized and their corresponding solubilities determined and rationalized with respect to the counterions' properties. The properties of the salt highly dependent on the nature of the counterion and, although there is considerable variation, some general conclusion can be drawn. For the alkyl amines series, increasing chain length leads to a reduction in solubility across all the acidic drugs studied and a reduction in melting point, thus contradicting simplistic relationships between solubility and melting point. Small, compact counterions consistently produce crystalline salts with high melting point accompanied with a modest improvement in solubility and the nature of hydrogen bonding between the ions has a major impact on the solubility.

Nanosizing of drugs: Effect on dissolution rate

PubMed Central

Dizaj, S. Maleki; Vazifehasl, Zh.; Salatin, S.; Adibkia, Kh.; Javadzadeh, Y.

2015-01-01

The solubility, bioavailability and dissolution rate of drugs are important parameters for achieving in vivo efficiency. The bioavailability of orally administered drugs depends on their ability to be absorbed via gastrointestinal tract. For drugs belonging to Class II of pharmaceutical classification, the absorption process is limited by drug dissolution rate in gastrointestinal media. Therefore, enhancement of the dissolution rate of these drugs will present improved bioavailability. So far several techniques such as physical and chemical modifications, changing in crystal habits, solid dispersion, complexation, solubilization and liquisolid method have been used to enhance the dissolution rate of poorly water soluble drugs. It seems that improvement of the solubility properties ofpoorly water soluble drugscan translate to an increase in their bioavailability. Nowadays nanotechnology offers various approaches in the area of dissolution enhancement of low aqueous soluble drugs. Nanosizing of drugs in the form of nanoparticles, nanocrystals or nanosuspensions not requiring expensive facilities and equipment or complicated processes may be applied as simple methods to increase the dissolution rate of poorly water soluble drugs. In this article, we attempted to review the effects of nanosizing on improving the dissolution rate of poorly aqueous soluble drugs. According to the reviewed literature, by reduction of drug particle size into nanometer size the total effective surface area is increased and thereby dissolution rate would be enhanced. Additionally, reduction of particle size leads to reduction of the diffusion layer thickness surrounding the drug particles resulting in the increment of the concentration gradient. Each of these process leads to improved bioavailability. PMID:26487886

Development and evaluation of methods for starch dissolution using asymmetrical flow field-flow fractionation. Part II: Dissolution of amylose.

PubMed

Perez-Rea, Daysi; Bergenståhl, Björn; Nilsson, Lars

2016-02-01

In this paper, we investigate whether dissolution in water under autoclaving conditions (140 °C, 20 min) or in dimethyl sulfoxide, DMSO (100 °C, 1 h), is preferable for characterization of amylose. Two types of amylose, potato and maize, were dissolved either in water using an autoclave or in DMSO. On the aqueous solutions obtained, the extent of molecular dissolution of the sample (referred to as the dissolution yield) was determined by enzymatic analysis as well as the molecular properties, such as molar mass and root-mean-square radius, obtained with asymmetrical flow field-flow fractionation coupled to multi-angle light scattering and differential refractive index detection (AF4-MALS-dRI). The results showed that both dissolution methods are efficient at dissolving amylose. However, AF4-MALS-dRI analysis revealed substantial differences. Amylose aqueous solutions obtained by dissolution in DMSO were relatively stable over time, but the dissolution method in autoclave caused some degradation of the molecules, and their solutions display a high tendency to retrograde.

Glass fiber dissolution in simulated lung fluid and measures needed to improve consistency and correspondence to in vivo dissolution.

PubMed Central

Mattson, S M

1994-01-01

The dissolution of a range of glass fibers including commercial glass and mineral wools has been studied using a modification of Gamble's solution in a flow system at pH 7.4 and 37 degrees C. Dissolution has been followed by weight loss, effluent analysis, and morphology change of fibers and bulk glass. Flow per glass surface area can strongly affect both dissolution rate and morphology due to the effect of the dissolution process on the fluid. Effluent pH is shown to be a guide for choice of optimum flow/area conditions. These conditions provide measurable concentrations of dissolved glass in the effluent while maintaining their concentrations below the point at which they significantly affect the dissolution process. SiO2 and Al2O3 vary widely in the extent to which they are involved in the leaching process, which removes alkalis, alkaline earths, and B2O3. This makes analysis of a single component in the effluent unsuitable as a means of comparing the dissolution rates of a wide range of compositions. PMID:7882963

3D geostatistical modelling for identifying sinkhole disaster potential zones around the Verkhnekamskoye potash deposit (Russia)

NASA Astrophysics Data System (ADS)

Royer, J. J.; Litaudon, J.; Filippov, L. O.; Lyubimova, T.; Maximovich, N.

2017-07-01

This work results from a cooperative scientific program between the Perm State University (Russia) and the University of Lorraine (France). Its objectives are to integrate modern 3D geomodeling in order to improve sustainable mining extraction, especially for predicting and avoiding the formation of sinkholes disaster potential zones. Systematic exploration drill holes performed in the Verkhnekamskoye potash deposit (Perm region, Russia) have been used to build a comprehensive 3D model for better understanding the spatial repartition of the ore quality (geometallurgy). A precise modelling of the mineralized layers allows an estimation of the in-situ ore reserves after interpolating by kriging the potassium (K) and magnesium (Mg) contents at the node of a regular centred grid (over a million cells). Total resources in potassium vary according to the cut-off between 4.7Gt @ 16.1 % K2O; 0.32 % MgCl2 for a cut-off grade at 13.1% K2O and 2.06 Gt @ 18.2 % K2O; 0.32 % MgCl2 at a cut-off of 16.5% K2O. Most of reserves are located in the KPI, KPII and KPIII layers, the KPI being the richest, and KPIII the largest in terms of tonnage. A systematic study of the curvature calculated along the roof of the mineralized layers points out the location of potential main faults which play a major role in the formation of sinkhole during exploitation. A risk map is then derived from this attribute.

Dissolution of steel slags in aqueous media.

PubMed

Yadav, Shashikant; Mehra, Anurag

2017-07-01

Steel slag is a major industrial waste in steel industries, and its dissolution behavior in water needs to be characterized in the larger context of its potential use as an agent for sequestering CO 2 . For this purpose, a small closed system batch reactor was used to conduct the dissolution of steel slags in an aqueous medium under various dissolution conditions. In this study, two different types of steel slags were procured from steel plants in India, having diverse structural features, mineralogical compositions, and particle sizes. The experiment was performed at different temperatures for 240 h of dissolution at atmospheric pressure. The dissolution rates of major and minor slag elements were quantified through liquid-phase elemental analysis using an inductively coupled plasma atomic emission spectroscopy at different time intervals. Advanced analytical techniques such as field emission gun-scanning electron microscope, energy-dispersive X-ray, BET, and XRD were also used to analyze mineralogical and structural changes in the slag particles. High dissolution of slags was observed irrespective of the particle size distribution, which suggests high carbonation potential. Concentrations of toxic heavy metals in the leachate were far below maximum acceptable limits. Thus, the present study investigates the dissolution behavior of different mineral ions of steel slag in aqueous media in light of its potential application in CO 2 sequestration.

Dissolution of Simulated and Radioactive Savannah River Site High-Level Waste Sludges with Oxalic Acid & Citric Acid Solutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

STALLINGS, MARY

untreated sludge solids. We recommend that these results be evaluated further to determine if these solutions contain sufficient neutron poisons. We observed low general corrosion rates in tests in which carbon steel coupons were contacted with solutions of oxalic acid, citric acid and mixtures of oxalic and citric acids. Wall thinning can be minimized by maintaining short contact times with these acid solutions. We recommend additional testing with oxalic and oxalic/citric acid mixtures to measure dissolution performance of sludges that have not been previously dried. This testing should include tests to clearly ascertain the effects of total acid strength and metal complexation on dissolution performance. Further work should also evaluate the downstream impacts of citric acid on the SRS High-Level Waste System (e.g., radiochemical separations in the Salt Waste Processing Facility and addition of organic carbon in the Saltstone and Defense Waste Processing facilities).« less

Does the stepwave model predict mica dissolution kinetics?

NASA Astrophysics Data System (ADS)

Kurganskaya, Inna; Arvidson, Rolf S.; Fischer, Cornelius; Luttge, Andreas

2012-11-01

The micas are a unique class of minerals because of their layered structure. A frequent question arising in mica dissolution studies is whether this layered structure radically changes the dissolution mechanism. We address this question here, using data from VSI and AFM experiments involving muscovite to evaluate crystallographic controls on mica dissolution. These data provide insight into the dissolution process, and reveal important links to patterns of dissolution observed in framework minerals. Under our experimental conditions (pH 9.4, 155 °C), the minimal global rate of normal surface retreat observed in VSI data was 1.42 × 10-10 mol/m2/s (σ = 27%) while the local rate observed at deep etch pits reached 416 × 10-10 mol/m2/s (σ = 49%). Complementary AFM data clearly show crystallographic control of mica dissolution, both in terms of step advance and the geometric influence of interlayer rotation (stacking periodicity). These observations indicate that basal/edge surface area ratios are highly variable and change continuously over the course of reaction, thus obviating their utility as characteristic parameters defining mica reactivity. Instead, these observations of overall dissolution rate and the influence of screw dislocations illustrate the link between atomic step movement and overall dissolution rate defined by surface retreat normal to the mica surface. Considered in light of similar observations available elsewhere in the literature, these relationships provide support for application of the stepwave model to mica dissolution kinetics. This approach provides a basic mechanistic link between the dissolution kinetics of phyllosilicates, framework silicates, and related minerals, and suggests a resolution to the general problem of mica reactivity.

Dissolution rate enhancement of gliclazide by ordered mixing.

PubMed

Saharan, Vikas A; Choudhury, Pratim K

2011-09-01

The poorly water soluble antidiabetic drug gliclazide was selected to study the effect of excipients on dissolution rate enhancement. Ordered mixtures of micronized gliclazide with lactose, mannitol, sorbitol, maltitol and sodium chloride were prepared by manual shaking of glass vials containing the drug and excipient(s). Different water soluble excipients, addition of surfactant and superdisintegrant, drug concentration and carrier particle size influenced the dissolution rate of the drug. Dissolution rate studies of the prepared ordered mixtures revealed an increase in drug dissolution with all water soluble excipients. The order of dissolution rate improvement for gliclazide was mannitol > lactose > maltitol > sorbitol > sodium chloride. Composite granules of the particle size range 355-710 μm were superior in increasing the drug dissolution rate from ordered mixtures. Reducing the carrier particle size decreased the dissolution rate of the drug as well as the increase in drug concentration. Kinetic modeling of drug release data fitted best the Hixson-Crowell model, which indicates that all the ordered mixture formulations followed the cube root law fairly well.

Chemical Evolution of Groundwater Near a Sinkhole Lake, Northern Florida: 2. Chemical Patterns, Mass Transfer Modeling, and Rates of Mass Transfer Reactions

NASA Astrophysics Data System (ADS)

Katz, Brian G.; Plummer, L. Niel; Busenberg, Eurybiades; Revesz, Kinga M.; Jones, Blair F.; Lee, Terrie M.

1995-06-01

Chemical patterns along evolutionary groundwater flow paths in silicate and carbonate aquifers were interpreted using solute tracers, carbon and sulfur isotopes, and mass balance reaction modeling for a complex hydrologic system involving groundwater inflow to and outflow from a sinkhole lake in northern Florida. Rates of dominant reactions along defined flow paths were estimated from modeled mass transfer and ages obtained from CFC-modeled recharge dates. Groundwater upgradient from Lake Barco remains oxic as it moves downward, reacting with silicate minerals in a system open to carbon dioxide (CO2), producing only small increases in dissolved species. Beneath and downgradient of Lake Barco the oxic groundwater mixes with lake water leakage in a highly reducing, silicate-carbonate mineral environment. A mixing model, developed for anoxic groundwater downgradient from the lake, accounted for the observed chemical and isotopic composition by combining different proportions of lake water leakage and infiltrating meteoric water. The evolution of major ion chemistry and the 13C isotopic composition of dissolved carbon species in groundwater downgradient from the lake can be explained by the aerobic oxidation of organic matter in the lake, anaerobic microbial oxidation of organic carbon, and incongruent dissolution of smectite minerals to kaolinite. The dominant process for the generation of methane was by the CO2 reduction pathway based on the isotopic composition of hydrogen (δ2H(CH4) = -186 to -234‰) and carbon (δ13C(CH4) = -65.7 to -72.3‰). Rates of microbial metabolism of organic matter, estimated from the mass transfer reaction models, ranged from 0.0047 to 0.039 mmol L-1 yr-1 for groundwater downgradient from the lake.

Use of partial dissolution techniques in geochemical exploration

USGS Publications Warehouse

Chao, T.T.

1984-01-01

Application of partial dissolution techniques to geochemical exploration has advanced from an early empirical approach to an approach based on sound geochemical principles. This advance assures a prominent future position for the use of these techniques in geochemical exploration for concealed mineral deposits. Partial dissolution techniques are classified as single dissolution or sequential multiple dissolution depending on the number of steps taken in the procedure, or as "nonselective" extraction and as "selective" extraction in terms of the relative specificity of the extraction. The choice of dissolution techniques for use in geochemical exploration is dictated by the geology of the area, the type and degree of weathering, and the expected chemical forms of the ore and of the pathfinding elements. Case histories have illustrated many instances where partial dissolution techniques exhibit advantages over conventional methods of chemical analysis used in geochemical exploration. ?? 1984.

Salt formation improved the properties of a candidate drug during early formulation development.

PubMed

Sigfridsson, Kalle; Ahlqvist, Matti; Lindsjö, Martin; Paulsson, Stefan

2018-07-30

The purpose of this study was to investigate if AZD5329, a dual neurokinin NK1/2 receptor antagonist, is a suitable candidate for further development as an oral immediate release (IR) solid dosage form as a final product. The neutral form of AZD5329 has only been isolated as amorphous material. In order to search for a solid material with improved physical and chemical stability and more suitable solid-state properties, a salt screen was performed. Crystalline material of a maleic acid salt and a fumaric acid salt of AZD5329 were obtained. X-ray powder diffractiometry, thermogravimetric analysis, differential scanning calorimetry and dynamic vapor sorption were used to investigate the physicochemical characteristics of the two salts. The fumarate salt of AZD5329 is anhydrous, the crystallization is reproducible and the hygroscopicity is acceptable. Early polymorphism assessment work using slurry technique did not reveal any better crystal modification or crystallinity for the fumarate salt. For the maleate salt, the form isolated originally was found to be a solvate, but an anhydrous form was found in later experiments; by suspension in water or acetone, by drying of the solvate to 100-120 °C or by subjecting the solvate form to conditions of 40 °C/75%RH for 3 months. The dissolution behavior and the chemical stability (in aqueous solutions, formulations and solid-state) of both salts were also studied and found to be satisfactory. The compound displays sensitivity to low pH, and the salt of the maleic acid, which is the stronger acid, shows more degradation during stability studies, in line with this observation. The presented data indicate that the substance fulfils basic requirements for further development of an IR dosage form, based on the characterization on crystalline salts of AZD5329. Copyright © 2018 Elsevier B.V. All rights reserved.

Electrolyte-Induced Surface Transformation and Transition-Metal Dissolution of Fully Delithiated LiNi0.8Co0.15Al0.05O2.

PubMed

Faenza, Nicholas V; Lebens-Higgins, Zachary W; Mukherjee, Pinaki; Sallis, Shawn; Pereira, Nathalie; Badway, Fadwa; Halajko, Anna; Ceder, Gerbrand; Cosandey, Frederic; Piper, Louis F J; Amatucci, Glenn G

2017-09-19

Enabling practical utilization of layered R3̅m positive electrodes near full delithiation requires an enhanced understanding of the complex electrode-electrolyte interactions that often induce failure. Using Li[Ni 0.8 Co 0.15 Al 0.05 ]O 2 (NCA) as a model layered compound, the chemical and structural stability in a strenuous thermal and electrochemical environment was explored. Operando microcalorimetry and electrochemical impedance spectroscopy identified a fingerprint for a structural decomposition and transition-metal dissolution reaction that occurs on the positive electrode at full delithiation. Surface-sensitive characterization techniques, including X-ray absorption spectroscopy and high-resolution transmission electron microscopy, measured a structural and morphological transformation of the surface and subsurface regions of NCA. Despite the bulk structural integrity being maintained, NCA surface degradation at a high state of charge induces excessive transition-metal dissolution and significant positive electrode impedance development, resulting in a rapid decrease in electrochemical performance. Additionally, the impact of electrolyte salt, positive electrode surface area, and surface Li 2 CO 3 content on the magnitude and character of the dissolution reaction was studied.

Dissolution of fludrocortisone from phospholipid coprecipitates.

PubMed

Vudathala, G K; Rogers, J A

1992-03-01

The physical properties and dissolution behavior of phospholipid coprecipitates of fludrocortisone acetate (FA) prepared from ethyl acetate, as well as the effect of added polymer, have been determined. The fraction dissolved after 90 min and the initial dissolution rate (IDR) of coprecipitates containing dimyristoyl phosphatidylcholine (DMPC) (4:1, w/w; FA:DMPC) were 77% and 3.5-fold greater than for FA at pH 2.0 and 37 degrees C. The mechanisms of dissolution were similar to those previously established for griseofulvin, but no aging occurred over 4 months at room temperature in a desiccator. The addition of 0.01 mol% of dextran (MW = 2 million) or 0.1 mol% of poly(lactic acid) reduced the fraction of FA dissolved in 90 min by 15% and reduced the IDR by 35%. The addition of poly(vinylpyrrolidone) (PVP) resulted in a minimum of dissolution efficiency at 1 mol% of PVP 10 (MW = 10,000) or PVP 24 (MW = 24,000) and at 0.1 mol% PVP 40 (MW = 40,000). Only PVP 24 influenced the melting point and heat of fusion of the coprecipitates (determined by differential thermal analysis). Coprecipitate dissolution was reasonably described by either second-order or Weibull distribution kinetic models. These results support the application of high drug-containing solid dispersions using phospholipids to increase the dissolution behavior of poorly water-soluble drug solvates and the possibility of modifying drug release by the incorporation of small amounts of polymers.

Arresting dissolution by interfacial rheology design

PubMed Central

Beltramo, Peter J.; Gupta, Manish; Alicke, Alexandra; Liascukiene, Irma; Gunes, Deniz Z.; Baroud, Charles N.

2017-01-01

A strategy to halt dissolution of particle-coated air bubbles in water based on interfacial rheology design is presented. Whereas previously a dense monolayer was believed to be required for such an “armored bubble” to resist dissolution, in fact engineering a 2D yield stress interface suffices to achieve such performance at submonolayer particle coverages. We use a suite of interfacial rheology techniques to characterize spherical and ellipsoidal particles at an air–water interface as a function of surface coverage. Bubbles with varying particle coverages are made and their resistance to dissolution evaluated using a microfluidic technique. Whereas a bare bubble only has a single pressure at which a given radius is stable, we find a range of pressures over which bubble dissolution is arrested for armored bubbles. The link between interfacial rheology and macroscopic dissolution of ∼ 100 μm bubbles coated with ∼ 1 μm particles is presented and discussed. The generic design rationale is confirmed by using nonspherical particles, which develop significant yield stress at even lower surface coverages. Hence, it can be applied to successfully inhibit Ostwald ripening in a multitude of foam and emulsion applications. PMID:28893993

Groundwater shapes sediment biogeochemistry and microbial diversity in a submerged Great Lake sinkhole.

PubMed

Kinsman-Costello, L E; Sheik, C S; Sheldon, N D; Allen Burton, G; Costello, D M; Marcus, D; Uyl, P A Den; Dick, G J

2017-03-01

For a large part of earth's history, cyanobacterial mats thrived in low-oxygen conditions, yet our understanding of their ecological functioning is limited. Extant cyanobacterial mats provide windows into the putative functioning of ancient ecosystems, and they continue to mediate biogeochemical transformations and nutrient transport across the sediment-water interface in modern ecosystems. The structure and function of benthic mats are shaped by biogeochemical processes in underlying sediments. A modern cyanobacterial mat system in a submerged sinkhole of Lake Huron (LH) provides a unique opportunity to explore such sediment-mat interactions. In the Middle Island Sinkhole (MIS), seeping groundwater establishes a low-oxygen, sulfidic environment in which a microbial mat dominated by Phormidium and Planktothrix that is capable of both anoxygenic and oxygenic photosynthesis, as well as chemosynthesis, thrives. We explored the coupled microbial community composition and biogeochemical functioning of organic-rich, sulfidic sediments underlying the surface mat. Microbial communities were diverse and vertically stratified to 12 cm sediment depth. In contrast to previous studies, which used low-throughput or shotgun metagenomic approaches, our high-throughput 16S rRNA gene sequencing approach revealed extensive diversity. This diversity was present within microbial groups, including putative sulfate-reducing taxa of Deltaproteobacteria, some of which exhibited differential abundance patterns in the mats and with depth in the underlying sediments. The biological and geochemical conditions in the MIS were distinctly different from those in typical LH sediments of comparable depth. We found evidence for active cycling of sulfur, methane, and nutrients leading to high concentrations of sulfide, ammonium, and phosphorus in sediments underlying cyanobacterial mats. Indicators of nutrient availability were significantly related to MIS microbial community composition, while LH

Low temperature dissolution flowsheet for plutonium metal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel, W. E.; Almond, P. M.; Rudisill, T. S.

2016-05-01

The H-Canyon flowsheet used to dissolve Pu metal for PuO 2 production utilizes boiling HNO 3. SRNL was requested to develop a complementary dissolution flowsheet at two reduced temperature ranges. The dissolution and H 2 generation rates of Pu metal were investigated using a dissolving solution at ambient temperature (20-30 °C) and for an intermediate temperature of 50-60 °C. Additionally, the testing included an investigation of the dissolution rates and characterization of the off-gas generated from the ambient temperature dissolution of carbon steel cans and the nylon bags that contain the Pu metal when charged to the dissolver.

Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride-containing bioactive glass.

PubMed

Shah, Furqan A; Brauer, Delia S; Wilson, Rory M; Hill, Robert G; Hing, Karin A

2014-03-01

Bioactive glasses are used clinically for bone regeneration, and their bioactivity and cell compatibility are often characterized in vitro, using physiologically relevant test solutions. The aim of this study was to show the influence of varying medium characteristics (pH, composition, presence of proteins) on glass dissolution and apatite formation. The dissolution behavior of a fluoride-containing bioactive glass (BG) was investigated over a period of one week in Eagle's Minimal Essential Medium with Earle's Salts (MEM), supplemented with either, (a) acetate buffer, (b) 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer, (c) HEPES + carbonate, or (d) HEPES + carbonate + fetal bovine serum. Results show pronounced differences in pH, ion release, and apatite formation over 1 week: Despite its acidic pH (pH 5.8 after BG immersion, as compared to pH 7.4-8.3 for HEPES-containing media), apatite formation was fastest in acetate buffered (HEPES-free) MEM. Presence of carbonate resulted in formation of calcite (calcium carbonate). Presence of serum proteins, on the other hand, delayed apatite formation significantly. These results confirm that the composition and properties of a tissue culture medium are important factors during in vitro experiments and need to be taken into consideration when interpreting results from dissolution or cell culture studies. Copyright © 2013 Wiley Periodicals, Inc.

The effect of the depth and groundwater on the formation of sinkholes or ground subsidence associated with abandoned room and pillar lignite mines under static and dynamic conditions

NASA Astrophysics Data System (ADS)

Aydan, Ö.; Ito, T.

2015-11-01

It is well known that some sinkholes or subsidence take place from time to time in the areas where abandoned room and pillar type mines exist. The author has been involved with the stability of abandoned mines beneath urbanized residential areas in Tokai region and there is a great concern about the stability of these abandoned mines during large earthquakes as well as in the long term. The 2003 Miyagi Hokubu and 2011 Great East Japan earthquakes caused great damage to abandoned mines and resulted in many collapses. The author presents the effect of the depth and groundwater on the formation of sinkholes or ground subsidence associated with abandoned room and pillar lignite mines under static and dynamic conditions and discusses the implications on the areas above abandoned lignite mines in this paper.

Initial dissolution kinetics of cocrystal of carbamazepine with nicotinamide.

PubMed

Hattori, Yusuke; Sato, Maiko; Otsuka, Makoto

2015-11-01

Objectives of this study are investigating the initial dissolution kinetics of the cocrystal of carbamazepine (CBZ) with nicotinamide (NIC) and understanding its initial dissolution process. Cocrystal solids of CBZ with NIC were prepared by co-milling and solvent evaporation methods. The formation of cocrystal solid was verified via X-ray diffraction measurement. Dissolution tests of the solids were performed using an original flow cell and ultraviolet-visible spectroscopic detector. The spectra monitored in situ were analyzed to determine the dissolved compounds separately using the classical least squares regression method. The initial dissolution profiles were interpreted using simultaneous model of dissolution and phase changes. In the initial dissolution, CBZ in the cocrystal structure dissolved in water and it was suggested that CBZ reached a metastable intermediate state simultaneously with dissolution. The cocrystal solid prepared by solvent evaporation provided a higher rate constant of the phase change than that prepared by co-milling. Our results thus support the use of evaporation as the method of choice to produce ordered cocrystal structures. We suggest that CBZ forms dihydrate during the dissolution process; however, during the initial phase of dissolution, CBZ changes to a metastable intermediate phase. © 2015 Royal Pharmaceutical Society.

Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution.

PubMed

Guo, Minshan; Wang, Ke; Qiao, Ning; Fábián, László; Sadiq, Ghazala; Li, Mingzhong

2017-12-04

Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide (FFA-NIC CO) were investigated at multiple length scales. At the molecular level, the interactions of crystal surfaces with a polymer were analyzed by observing etching pattern changes using atomic force microscopy. At the macroscopic scale, dissolution rates of particular faces of a single crystal were determined by measurement of the physical retreat velocities of the faces using optical light microscopy. In the bulk experiments, the FFA concentration in a dissolution medium in the absence or presence of a polymer was measured under both sink and nonsink conditions. It has been found that the dissolution mechanisms of FFA-TP CO are controlled by the defect sites of the crystal surface and by precipitation of the parent drug FFA as individual crystals in the bulk fluid. In contrast, the dissolution mechanisms of FFA-NIC CO are controlled by surface layer removal and by a surface precipitation mechanism, where the parent drug FFA precipitates directly onto the surface of the dissolving cocrystals. Through controlling the dissolution environment by predissolving a polymer, PVP or PVP-VA, which can interact with the crystal surface to alter its dissolution properties, improved solubility, and dissolution rates of FFA-TP CO and FFA-NIC CO have been demonstrated.

Simulating Salt Movement using a Coupled Salinity Transport Model in a Variably Saturated Agricultural Groundwater System

NASA Astrophysics Data System (ADS)

Tavakoli Kivi, S.; Bailey, R. T.; Gates, T. K.

2017-12-01

Salinization is one of the major concerns in irrigated agricultural fields. Increasing salinity concentrations are due principally to a high water table that results from excessive irrigation, canal seepage, and a lack of efficient drainage systems, and lead to decreasing crop yield. High groundwater salinity loading to nearby river systems also impacts downstream areas, with saline river water diverted for application on irrigated fields. To assess the different strategies for salt remediation, we present a reactive transport model (UZF-RT3D) coupled with a salinity equilibrium chemistry module for simulating the fate and transport of salt ions in a variably-saturated agricultural groundwater system. The developed model accounts not for advection, dispersion, nitrogen and sulfur cycling, oxidation-reduction, sorption, complexation, ion exchange, and precipitation/dissolution of salt minerals. The model is applied to a 500 km2 region within the Lower Arkansas River Valley (LARV) in southeastern Colorado, an area acutely affected by salinization in the past few decades. The model is tested against salt ion concentrations in the saturated zone, total dissolved solid concentrations in the unsaturated zone, and salt groundwater loading to the Arkansas River. The model now can be used to investigate salinity remediation strategies.

Catalysis and chemical mechanisms of calcite dissolution in seawater.

PubMed

Subhas, Adam V; Adkins, Jess F; Rollins, Nick E; Naviaux, John; Erez, Jonathan; Berelson, William M

2017-07-18

Near-equilibrium calcite dissolution in seawater contributes significantly to the regulation of atmospheric [Formula: see text] on 1,000-y timescales. Despite many studies on far-from-equilibrium dissolution, little is known about the detailed mechanisms responsible for calcite dissolution in seawater. In this paper, we dissolve 13 C-labeled calcites in natural seawater. We show that the time-evolving enrichment of [Formula: see text] in solution is a direct measure of both dissolution and precipitation reactions across a large range of saturation states. Secondary Ion Mass Spectrometer profiles into the 13 C-labeled solids confirm the presence of precipitated material even in undersaturated conditions. The close balance of precipitation and dissolution near equilibrium can alter the chemical composition of calcite deeper than one monolayer into the crystal. This balance of dissolution-precipitation shifts significantly toward a dissolution-dominated mechanism below about [Formula: see text] Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate across all saturation states, and the effect is most pronounced close to equilibrium. This finding suggests that the rate of hydration of [Formula: see text] is a rate-limiting step for calcite dissolution in seawater. We then interpret our dissolution data in a framework that incorporates both solution chemistry and geometric constraints on the calcite solid. Near equilibrium, this framework demonstrates a lowered free energy barrier at the solid-solution interface in the presence of CA. This framework also indicates a significant change in dissolution mechanism at [Formula: see text], which we interpret as the onset of homogeneous etch pit nucleation.

Olivine dissolution from Indian dunite in saline water.

PubMed

Agrawal, Amit Kumar; Mehra, Anurag

2016-11-01

The rate and mechanism of olivine dissolution was studied using naturally weathered dunite FO 98.21 (Mg 1.884 Fe 0.391 SiO 4 ) from an Indian source, that also contains serpentine mineral lizardite. A series of batch dissolution experiments were carried out to check the influence of temperature (30-75 ∘ C), initial dunite concentration (0.5 and 20 g/L), and salinity (0-35 g/L NaCl) under fixed head space CO 2 pressure (P[Formula: see text] = 1 barg) on dunite dissolution. Dissolved Mg, Si, and Fe concentrations were determined by inductive coupled plasma atomic emission spectroscopy. End-product solids were characterized by scanning electron microscopy and X-ray diffraction. Initially, rates of dissolution of Si and Mg were observed to be in stoichiometric proportion. After 8 h, the dissolution rate was observed to decline. At the end of the experiment (504 h), an amorphous silica-rich layer was observed over the dunite surface. This results in decay of the dissolution rate. The operating conditions (i.e., salinity, temperature, and mineral loading) affect the dissolution kinetics in a very complex manner because of which the observed experimental trends do not exhibit a direct trend.

20 CFR 404.1219 - Dissolution of political subdivision.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Dissolution of political subdivision. 404... Agreements Is Obtained and Continues § 404.1219 Dissolution of political subdivision. If a political... satisfactory evidence of its dissolution or nonexistence. The evidence must establish that the entity is not...

20 CFR 404.1219 - Dissolution of political subdivision.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Dissolution of political subdivision. 404... Agreements Is Obtained and Continues § 404.1219 Dissolution of political subdivision. If a political... satisfactory evidence of its dissolution or nonexistence. The evidence must establish that the entity is not...

20 CFR 404.1219 - Dissolution of political subdivision.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Dissolution of political subdivision. 404... Agreements Is Obtained and Continues § 404.1219 Dissolution of political subdivision. If a political... satisfactory evidence of its dissolution or nonexistence. The evidence must establish that the entity is not...

20 CFR 404.1219 - Dissolution of political subdivision.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Dissolution of political subdivision. 404... Agreements Is Obtained and Continues § 404.1219 Dissolution of political subdivision. If a political... satisfactory evidence of its dissolution or nonexistence. The evidence must establish that the entity is not...

20 CFR 404.1219 - Dissolution of political subdivision.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Dissolution of political subdivision. 404... Agreements Is Obtained and Continues § 404.1219 Dissolution of political subdivision. If a political... satisfactory evidence of its dissolution or nonexistence. The evidence must establish that the entity is not...

In-vitro Drug Dissolution Studies in Medicinal Compounds.

PubMed

Bozal-Palabiyik, Burcin; Uslu, Bengi; Ozkan, Yalcin; Ozkan, Sibel A

2018-03-22

After oral administration, drug absorption from solid dosage forms depend on the release of the drug active compounds from the dosage form, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. Dissolution testing is an essential part of designing more effective solid dosage forms in pharmaceutical industry. Moreover dissolution testing contributes to the selection of appropriate formulation excipients for improving the dosage form efficiency. This study aims to analyze in-vitro drug dissolution testing in solid dosage forms since 2010 in order to present a comprehensive outlook of recent trends. In doing that the previous studies in the literature are summarized in the form of a table to demonstrate the apparatuses used for dissolution testing, the media in which the solid dosage form is dissolved, the method preferred for analysis from dissolution media, the conditions of analyses and the results obtained. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Fracture Dissolution of Carbonate Rock: An Innovative Process for Gas Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

James W. Castle; Ronald W. Falta; David Bruce

2006-10-31

The goal of the project is to develop and assess the feasibility and economic viability of an innovative concept that may lead to commercialization of new gas-storage capacity near major markets. The investigation involves a new approach to developing underground gas storage in carbonate rock, which is present near major markets in many areas of the United States. Because of the lack of conventional gas storage and the projected growth in demand for storage capacity, many of these areas are likely to experience shortfalls in gas deliverability. Since depleted gas reservoirs and salt formations are nearly non-existent in many areas,more » alternatives to conventional methods of gas storage are required. The need for improved methods of gas storage, particularly for ways to meet peak demand, is increasing. Gas-market conditions are driving the need for higher deliverability and more flexibility in injection/withdrawal cycling. In order to meet these needs, the project involves an innovative approach to developing underground storage capacity by creating caverns in carbonate rock formations by acid dissolution. The basic concept of the acid-dissolution method is to drill to depth, fracture the carbonate rock layer as needed, and then create a cavern using an aqueous acid to dissolve the carbonate rock. Assessing feasibility of the acid-dissolution method included a regional geologic investigation. Data were compiled and analyzed from carbonate formations in six states: Indiana, Ohio, Kentucky, West Virginia, Pennsylvania, and New York. To analyze the requirements for creating storage volume, the following aspects of the dissolution process were examined: weight and volume of rock to be dissolved; gas storage pressure, temperature, and volume at depth; rock solubility; and acid costs. Hydrochloric acid was determined to be the best acid to use because of low cost, high acid solubility, fast reaction rates with carbonate rock, and highly soluble products (calcium

Combinatorial localized dissolution analysis: Application to acid-induced dissolution of dental enamel and the effect of surface treatments.

PubMed

Parker, Alexander S; Al Botros, Rehab; Kinnear, Sophie L; Snowden, Michael E; McKelvey, Kim; Ashcroft, Alexander T; Carvell, Mel; Joiner, Andrew; Peruffo, Massimo; Philpotts, Carol; Unwin, Patrick R

2016-08-15

A combination of scanning electrochemical cell microscopy (SECCM) and atomic force microscopy (AFM) is used to quantitatively study the acid-induced dissolution of dental enamel. A micron-scale liquid meniscus formed at the end of a dual barrelled pipette, which constitutes the SECCM probe, is brought into contact with the enamel surface for a defined period. Dissolution occurs at the interface of the meniscus and the enamel surface, under conditions of well-defined mass transport, creating etch pits that are then analysed via AFM. This technique is applied to bovine dental enamel, and the effect of various treatments of the enamel surface on acid dissolution (1mM HNO3) is studied. The treatments investigated are zinc ions, fluoride ions and the two combined. A finite element method (FEM) simulation of SECCM mass transport and interfacial reactivity, allows the intrinsic rate constant for acid-induced dissolution to be quantitatively determined. The dissolution of enamel, in terms of Ca(2+) flux ( [Formula: see text] ), is first order with respect to the interfacial proton concentration and given by the following rate law: [Formula: see text] , with k0=0.099±0.008cms(-1). Treating the enamel with either fluoride or zinc ions slows the dissolution rate, although in this model system the partly protective barrier only extends around 10-20nm into the enamel surface, so that after a period of a few seconds dissolution of modified surfaces tends towards that of native enamel. A combination of both treatments exhibits the greatest protection to the enamel surface, but the effect is again transient. Copyright © 2016 Elsevier Inc. All rights reserved.

Dissolution testing of orally disintegrating tablets.

PubMed

Kraemer, Johannes; Gajendran, Jayachandar; Guillot, Alexis; Schichtel, Julian; Tuereli, Akif

2012-07-01

For industrially manufactured pharmaceutical dosage forms, product quality tests and performance tests are required to ascertain the quality of the final product. Current compendial requirements specify a disintegration and/or a dissolution test to check the quality of oral solid dosage forms. These requirements led to a number of compendial monographs for individual products and, at times, the results obtained may not be reflective of the dosage form performance. Although a general product performance test is desirable for orally disintegrating tablets (ODTs), the complexity of the release controlling mechanisms and short time-frame of release make such tests difficult to establish. For conventional oral solid dosage forms (COSDFs), disintegration is often considered to be the prerequisite for subsequent dissolution. Hence, disintegration testing is usually insufficient to judge product performance of COSDFs. Given the very fast disintegration of ODTs, the relationship between disintegration and dissolution is worthy of closer scrutiny. This article reviews the current status of dissolution testing of ODTs to establish the product quality standards. Based on experimental results, it appears that it may be feasible to rely on the dissolution test without a need for disintegration studies for selected ODTs on the market. © 2012 The Authors. JPP © 2012 Royal Pharmaceutical Society.

Performance Assessment of a Generic Repository in Bedded Salt for DOE-Managed Nuclear Waste

NASA Astrophysics Data System (ADS)

Stein, E. R.; Sevougian, S. D.; Hammond, G. E.; Frederick, J. M.; Mariner, P. E.

2016-12-01

A mined repository in salt is one of the concepts under consideration for disposal of DOE-managed defense-related spent nuclear fuel (SNF) and high level waste (HLW). Bedded salt is a favorable medium for disposal of nuclear waste due to its low permeability, high thermal conductivity, and ability to self-heal. Sandia's Generic Disposal System Analysis framework is used to assess the ability of a generic repository in bedded salt to isolate radionuclides from the biosphere. The performance assessment considers multiple waste types of varying thermal load and radionuclide inventory, the engineered barrier system comprising the waste packages, backfill, and emplacement drifts, and the natural barrier system formed by a bedded salt deposit and the overlying sedimentary sequence (including an aquifer). The model simulates disposal of nearly the entire inventory of DOE-managed, defense-related SNF (excluding Naval SNF) and HLW in a half-symmetry domain containing approximately 6 million grid cells. Grid refinement captures the detail of 25,200 individual waste packages in 180 disposal panels, associated access halls, and 4 shafts connecting the land surface to the repository. Equations describing coupled heat and fluid flow and reactive transport are solved numerically with PFLOTRAN, a massively parallel flow and transport code. Simulated processes include heat conduction and convection, waste package failure, waste form dissolution, radioactive decay and ingrowth, sorption, solubility limits, advection, dispersion, and diffusion. Simulations are run to 1 million years, and radionuclide concentrations are observed within an aquifer at a point approximately 4 kilometers downgradient of the repository. The software package DAKOTA is used to sample likely ranges of input parameters including waste form dissolution rates and properties of engineered and natural materials in order to quantify uncertainty in predicted concentrations and sensitivity to input parameters. Sandia

32 CFR 202.10 - RAB adjournment and dissolution.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false RAB adjournment and dissolution. 202.10 Section... dissolution. (a) RAB adjournment—(1) Requirements for RAB adjournment. An Installation Commander may adjourn a... Commander decides to adjourn the RAB. (b) RAB dissolution—(1) Requirements for RAB dissolution. An...

32 CFR 202.10 - RAB adjournment and dissolution.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false RAB adjournment and dissolution. 202.10 Section... dissolution. (a) RAB adjournment—(1) Requirements for RAB adjournment. An Installation Commander may adjourn a... Commander decides to adjourn the RAB. (b) RAB dissolution—(1) Requirements for RAB dissolution. An...

32 CFR 202.10 - RAB adjournment and dissolution.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false RAB adjournment and dissolution. 202.10 Section... dissolution. (a) RAB adjournment—(1) Requirements for RAB adjournment. An Installation Commander may adjourn a... Commander decides to adjourn the RAB. (b) RAB dissolution—(1) Requirements for RAB dissolution. An...

32 CFR 202.10 - RAB adjournment and dissolution.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false RAB adjournment and dissolution. 202.10 Section... dissolution. (a) RAB adjournment—(1) Requirements for RAB adjournment. An Installation Commander may adjourn a... Commander decides to adjourn the RAB. (b) RAB dissolution—(1) Requirements for RAB dissolution. An...

Carbon in oxides and silicates - Dissolution versus exsolution

NASA Technical Reports Server (NTRS)

Freund, F.

1986-01-01

A theory of CO2 dissolution in the solid state is developed, using the idea proposed by Freund (1983) concerning dissolution of CO/CO2 in MgO on the basis of their experimental results obtained with an MgO-containing carbon impurity. It is shown that the dissolution mechanism may be linked to an internal redox reaction by which a certain number of lattice oxygens change their formal oxidation state from -2 to -1, while the carbon becomes reduced. The similarities between the mechanisms of CO and/or CO2 dissolution and that of H2O dissolution are pointed out. A hypothesis is proposed concerning the exsolution of reduced carbon from supersaturated solid solutions under conditions which permit C-C bond formation.

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs.

PubMed

Forner, Kristin; Roos, Carl; Dahlgren, David; Kesisoglou, Filippos; Konerding, Moritz A; Mazur, Johanna; Lennernäs, Hans; Langguth, Peter

2017-02-01

Prediction of the in vivo absorption of poorly soluble drugs may require simultaneous dissolution/permeation experiments. In vivo predictive media have been modified for permeation experiments with Caco-2 cells, but not for excised rat intestinal segments. The present study aimed at improving the setup of dissolution/permeation experiments with excised rat intestinal segments by assessing suitable donor and receiver media. The regional compatibility of rat intestine in Ussing chambers with modified Fasted and Fed State Simulated Intestinal Fluids (Fa/FeSSIF mod ) as donor media was evaluated via several parameters that reflect the viability of the excised intestinal segments. Receiver media that establish sink conditions were investigated for their foaming potential and toxicity. Dissolution/permeation experiments with the optimized conditions were then tested for two particle sizes of the BCS class II drug aprepitant. Fa/FeSSIF mod were toxic for excised rat ileal sheets but not duodenal sheets, the compatibility with jejunal segments depended on the bile salt concentration. A non-foaming receiver medium containing bovine serum albumin (BSA) and Antifoam B was nontoxic. With these conditions, the permeation of nanosized aprepitant was higher than of the unmilled drug formulations. The compatibility of Fa/FeSSIF mod depends on the excised intestinal region. The chosen conditions enable dissolution/permeation experiments with excised rat duodenal segments. The experiments correctly predicted the superior permeation of nanosized over unmilled aprepitant that is observed in vivo. The optimized setup uses FaSSIF mod as donor medium, excised rat duodenal sheets as permeation membrane and a receiver medium containing BSA and Antifoam B.

High temperature dissolution of oxides in complexing media

NASA Astrophysics Data System (ADS)

Sathyaseelan, Valil S.; Rufus, Appadurai L.; Subramanian, Hariharan; Bhaskarapillai, Anupkumar; Wilson, Shiny; Narasimhan, Sevilimedu V.; Velmurugan, Sankaralingam

2011-12-01

Dissolution of transition metal oxides such as magnetite (Fe 3O 4), mixed ferrites (NiFe 2O 4, ZnFe 2O 4, MgFe 2O 4), bonaccordite (Ni 2FeBO 5) and chromium oxide (Cr 2O 3) in organic complexing media was attempted at higher temperatures (80-180 °C). On increasing the temperature from 80 to 180 °C, the dissolution rate of magnetite in nitrilo triacetic acid (NTA) medium increased six folds. The trend obtained for the dissolution of other oxides was ZnFe 2O 4 > NiFe 2O 4 > MgFe 2O 4 > Cr 2O 3, which followed the same trend as the lability of their metal-oxo bonds. Other complexing agents such as ethylene diamine tetra acetic acid (EDTA), pyridine dicarboxylic acid (PDCA), citric acid and reducing agents viz., oxalic acid and ascorbic acid were also evaluated for their oxide dissolution efficiency at 160 °C. EDTA showed maximum dissolution rate of 21.4 μm/h for magnetite. Addition of oxalic acid/ascorbic acid to complexing media (NTA/EDTA) showed identical effect on the dissolution of magnetite. Addition of hydrazine, another reducing agent, to NTA decreased the rate of dissolution of magnetite by 50%.

Landslides, floods and sinkholes in a karst environment: the 1-6 September 2014 Gargano event, southern Italy

NASA Astrophysics Data System (ADS)

Martinotti, Maria Elena; Pisano, Luca; Marchesini, Ivan; Rossi, Mauro; Peruccacci, Silvia; Brunetti, Maria Teresa; Melillo, Massimo; Amoruso, Giuseppe; Loiacono, Pierluigi; Vennari, Carmela; Vessia, Giovanna; Trabace, Maria; Parise, Mario; Guzzetti, Fausto

2017-03-01

In karst environments, heavy rainfall is known to cause multiple geohydrological hazards, including inundations, flash floods, landslides and sinkholes. We studied a period of intense rainfall from 1 to 6 September 2014 in the Gargano Promontory, a karst area in Puglia, southern Italy. In the period, a sequence of torrential rainfall events caused severe damage and claimed two fatalities. The amount and accuracy of the geographical and temporal information varied for the different hazards. The temporal information was most accurate for the inundation caused by a major river, less accurate for flash floods caused by minor torrents and even less accurate for landslides. For sinkholes, only generic information on the period of occurrence of the failures was available. Our analysis revealed that in the promontory, rainfall-driven hazards occurred in response to extreme meteorological conditions and that the karst landscape responded to the torrential rainfall with a threshold behaviour. We exploited the rainfall and the landslide information to design the new ensemble-non-exceedance probability (E-NEP) algorithm for the quantitative evaluation of the possible occurrence of rainfall-induced landslides and of related geohydrological hazards. The ensemble of the metrics produced by the E-NEP algorithm provided better diagnostics than the single metrics often used for landslide forecasting, including rainfall duration, cumulated rainfall and rainfall intensity. We expect that the E-NEP algorithm will be useful for landslide early warning in karst areas and in other similar environments. We acknowledge that further tests are needed to evaluate the algorithm in different meteorological, geological and physiographical settings.

12 CFR 239.16 - Voluntary dissolution.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Voluntary dissolution. 239.16 Section 239.16 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.16 Voluntary dissolution...

12 CFR 239.16 - Voluntary dissolution.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Voluntary dissolution. 239.16 Section 239.16 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.16 Voluntary dissolution...

12 CFR 239.16 - Voluntary dissolution.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Voluntary dissolution. 239.16 Section 239.16 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.16 Voluntary dissolution...

A Kinetics and Equilibrium Study of Vanadium Dissolution from Vanadium Oxides and Phosphates in Battery Electrolytes: Possible Impacts on ICD Battery Performance.

PubMed

Bock, David C; Marschilok, Amy C; Takeuchi, Kenneth J; Takeuchi, Esther S

2013-06-01

Silver vanadium oxide (Ag 2 V 4 O 11 , SVO) has enjoyed widespread commercial success over the past 30 years as a cathode material for implantable cardiac defibrillator (ICD) batteries. Recently, silver vanadium phosphorous oxide (Ag 2 VO 2 PO 4 , SVPO) has been studied as possibly combining the desirable thermal stability aspects of LiFePO 4 with the electrical conductivity of SVO. Further, due to the noted insoluble nature of most phosphate salts, a lower material solubility of SVPO relative to SVO is anticipated. Thus, the first vanadium dissolution studies of SVPO in battery electrolyte solutions are described herein. The equilibrium solubility of SVPO was ~5 times less than SVO, with a rate constant of dissolution ~3.5 times less than that of SVO. The vanadium dissolution in SVO and SVPO can be adequately described with a diffusion layer model, as supported by the Noyes-Whitney equation. Cells prepared with vanadium-treated anodes displayed higher AC impedance and DC resistance relative to control anodes. These data support the premise that SVPO cells are likely to exhibit reduced cathode solubility and thus less affected by increased cell resistance due to cathode solubility compared to SVO based cells.

Geological and environmental implications of the evaporite karst in Spain

NASA Astrophysics Data System (ADS)

Gutiérrez, F.; Calaforra, J. M.; Cardona, F.; Ortí, F.; Durán, J. J.; Garay, P.

2008-01-01

In Spain, evaporite outcrops cover approximately 7% of the total area of the country. Most of the evaporitic formations are made up of Ca-sulfates (gypsum/anhydrite) or Ca-sulfates and halite. Certain Paleogene marine evaporites also contain K-Mg-chlorides, and some Tertiary continental formations bear substantial amounts of Na-sulfates in the subsurface (glauberite and thenardite). Mesozoic evaporitic formations commonly wedge out towards the ground surface, passing into condensed sequences and dissolution-collapse breccias. Some of these highly porous breccias constitute major regional aquifers. In several areas, interstratal karstification of the evaporites has given rise to gravitational deformations such as basin structures, monoclines, and collapse structures covering several square kilometers that record a cumulative subsidence in excess of 200 m (Teruel and Calatayud Grabens). A widespread consequence of evaporite dissolution processes in Spain is the hydrochemical degradation of surface waters. Some of the largest and most outstanding lake systems, from an environmental perspective, occur in karstic depressions developed in evaporitic formations (Fuente de Piedra, Gallocanta, Bujaraloz, and Bañolas lakes). Sinkhole activity is a major geohazard in several evaporite karst areas. The sinkhole risk has a particularly high impact in sectors where Tertiary evaporites are overlain by Quaternary alluvial aquifers (Calatayud, Zaragoza, and Madrid areas). Some of the detrimental effects of subsidence include severe damage to historical monuments (Calatayud), the demolition of a whole village (Puilatos), or the derailment of a freight train (Zaragoza area). The deepest gypsum caves are found in Triassic diapiric structures (El Sumidor Cave, 210 m deep), and the longest ones are developed in horizontally lying Neogene sequences (Sorbas caves, and Estremera maze cave). The Cardona diapir hosts salt caves up to 4,300 m long whose genesis is related to flooding of mine

Localized thermal anomalies in haloclines of coastal Yucatan sinkholes.

PubMed

Stoessell, Ronald K; Coke, James G; Easley, Dale H

2002-01-01

A temperature spike is reported in the haloclines of three Yucatan sinkholes along a 1 km NW-SE transect from 5 to 4 km inland from the Caribbean coast. The temperature spike decreases in magnitude from 3.5 degrees C to 0.2 degrees C, approaching the coast. The anomaly does not vary diurnally and does not extend down into the underlying sea water. These conditions are inconsistent with explanations such as radiation absorption within the halocline, in situ microbially mediated sulfate reduction within the halocline and the underlying sea water, and sulfide oxidation by photosynthetic purple and green bacteria within the halocline. One explanation consistent with the shape and halocline location of the temperature spike involves a localized sea water convection cell operating near the coast. Cold sea water from the Caribbean Sea enters the coastal limestone at depths of a few hundred meters and heats up because of the geothermal gradient, buoyantly rising in vertical fractures within the unconfined aquifer. Blocked by the less dense fresh water, the movement stops in the halocline where the warm sea water mixes with brackish water. The convection cycle would be completed by the coastward movement of cooling brackish water. The observed temperature anomalies could possibly be snapshots of this warm layer moving coastward.

Factors associated with relationship dissolution and post-dissolution adjustment among lesbian adoptive couples.

PubMed

Farr, Rachel H

2017-01-02

Same-sex adoptive couples are increasingly visible, yet few studies have addressed relationship stability and dissolution among these couples. In this study, using a theoretical framework based on Investment Models and Vulnerability-Stress-Adaptation Theory, factors associated with dissolution and post-dissolution adjustment among 27 lesbian adoptive couples were examined across two points. At Wave 1, all 27 couples were together; children were on average 3 years old. Results revealed that nearly one third broke up over 5 years (between Waves 1 and 2). Factors related to shorter relationship length and undermining coparenting at Wave 1 distinguished women who later broke up versus stayed together. Worse mental health at Wave 2 characterized women in dissolved rather than sustained relationships, even with comparable individual adjustment at Wave 1. Weaker parenting alliance and greater dissatisfaction with childcare divisions were reported by women no longer with their partners at Wave 2 as compared with those in enduring partnerships. This research has implications for understanding lesbian relationship dynamics and associations with individual adjustment.

Seeking sunlight: rapid phototactic motility of filamentous mat-forming cyanobacteria optimize photosynthesis and enhance carbon burial in Lake Huron’s submerged sinkholes

PubMed Central

Biddanda, Bopaiah A.; McMillan, Adam C.; Long, Stephen A.; Snider, Michael J.; Weinke, Anthony D.

2015-01-01

We studied the motility of filamentous mat-forming cyanobacteria consisting primarily of Oscillatoria-like cells growing under low-light, low-oxygen, and high-sulfur conditions in Lake Huron’s submerged sinkholes using in situ observations, in vitro measurements and time-lapse microscopy. Gliding movement of the cyanobacterial trichomes (100–10,000 μm long filaments, composed of cells ∼10 μm wide and ∼3 μm tall) revealed individual as well as group-coordinated motility. When placed in a petri dish and dispersed in ground water from the sinkhole, filaments re-aggregated into defined colonies within minutes, then dispersed again. Speed of individual filaments increased with temperature from ∼50 μm min-1 or ∼15 body lengths min-1 at 10°C to ∼215 μm min-1 or ∼70 body lengths min-1 at 35°C – rates that are rapid relative to non-flagellated/ciliated microbes. Filaments exhibited precise and coordinated positive phototaxis toward pinpoints of light and congregated under the light of foil cutouts. Such light-responsive clusters showed an increase in photosynthetic yield – suggesting phototactic motility aids in light acquisition as well as photosynthesis. Once light source was removed, filaments slowly spread out evenly and re-aggregated, demonstrating coordinated movement through inter-filament communication regardless of light. Pebbles and pieces of broken shells placed upon intact mat were quickly covered by vertically motile filaments within hours and became fully buried in the anoxic sediments over 3–4 diurnal cycles – likely facilitating the preservation of falling debris. Coordinated horizontal and vertical filament motility optimize mat cohesion and dynamics, photosynthetic efficiency and sedimentary carbon burial in modern-day sinkhole habitats that resemble the shallow seas in Earth’s early history. Analogous cyanobacterial motility may have played a key role in the oxygenation of the planet by optimizing photosynthesis while

Long-period Seismicity at the Napoleonville Salt Dome: Implications for Local Seismic Monitoring of Underground Hydrocarbon Storage Caverns

NASA Astrophysics Data System (ADS)

Dreger, D. S.; Ford, S. R.; Nayak, A.

2015-12-01

The formation of a large sinkhole at the Napoleonville salt dome, Assumption Parish, Louisiana, in August 2012 was accompanied by a rich sequence of complex seismic events, including long-period (LP) events that were recorded 11 km away at Transportable Array station 544A in White Castle, Louisiana. The LP events have relatively little energy at short periods, which make them difficult to detect using standard high-frequency power detectors, and the majority of energy that reaches the station is peaked near 0.4 Hz. The analysis of the local records reveals that the onset of the 0.4 Hz signals coincides with the S-wave arrival, and therefore it may be a shaking induced resonance in a fluid filled cavern. We created a low-frequency (0.1-0.6 Hz) power detector (short-term average / long-term average) that operated on all three components of the broadband instrument, since considerable energy was detected on the horizontal components. The detections from the power detector were then used as templates in three-channel correlation detectors thereby increasing the number of detections by a little more than a factor of two to nearly 3000. The rate of LP events is approximately one event every other day at the beginning of recording in March 2011. Around 2 May 2012 the rate changes to approximately 7 events per day and then increases to 25 events per day at the beginning of July 2012. Finally, in the days leading up to the sinkhole formation there are approximately 200 LP events per day. The analysis of these events could aid in the development of local seismic monitoring methods for underground industrial storage caverns. Prepared by LLNL under Contract DE-AC52-07NA27344.

Physical heterogeneity control on effective mineral dissolution rates

NASA Astrophysics Data System (ADS)

Jung, Heewon; Navarre-Sitchler, Alexis

2018-04-01

Hydrologic heterogeneity may be an important factor contributing to the discrepancy in laboratory and field measured dissolution rates, but the governing factors influencing mineral dissolution rates among various representations of physical heterogeneity remain poorly understood. Here, we present multiple reactive transport simulations of anorthite dissolution in 2D latticed random permeability fields and link the information from local grid scale (1 cm or 4 m) dissolution rates to domain-scale (1m or 400 m) effective dissolution rates measured by the flux-weighted average of an ensemble of flow paths. We compare results of homogeneous models to heterogeneous models with different structure and layered permeability distributions within the model domain. Chemistry is simplified to a single dissolving primary mineral (anorthite) distributed homogeneously throughout the domain and a single secondary mineral (kaolinite) that is allowed to dissolve or precipitate. Results show that increasing size in correlation structure (i.e. long integral scales) and high variance in permeability distribution are two important factors inducing a reduction in effective mineral dissolution rates compared to homogeneous permeability domains. Larger correlation structures produce larger zones of low permeability where diffusion is an important transport mechanism. Due to the increased residence time under slow diffusive transport, the saturation state of a solute with respect to a reacting mineral approaches equilibrium and reduces the reaction rate. High variance in permeability distribution favorably develops large low permeability zones that intensifies the reduction in mixing and effective dissolution rate. However, the degree of reduction in effective dissolution rate observed in 1 m × 1 m domains is too small (<1% reduction from the corresponding homogeneous case) to explain several orders of magnitude reduction observed in many field studies. When multimodality in permeability

25 CFR 11.606 - Dissolution proceedings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... marriage may initiate dissolution proceedings. (b) If a proceeding is commenced by one of the parties, the... proceeding for dissolution of marriage or legal separation shall allege that the marriage is irretrievably... under the jurisdiction of the court of each party; (2) The date of the marriage and the place at which...

Catalysis and chemical mechanisms of calcite dissolution in seawater

PubMed Central

Adkins, Jess F.; Rollins, Nick E.; Naviaux, John; Erez, Jonathan; Berelson, William M.

2017-01-01

Near-equilibrium calcite dissolution in seawater contributes significantly to the regulation of atmospheric CO2 on 1,000-y timescales. Despite many studies on far-from-equilibrium dissolution, little is known about the detailed mechanisms responsible for calcite dissolution in seawater. In this paper, we dissolve 13C-labeled calcites in natural seawater. We show that the time-evolving enrichment of 𝜹13C in solution is a direct measure of both dissolution and precipitation reactions across a large range of saturation states. Secondary Ion Mass Spectrometer profiles into the 13C-labeled solids confirm the presence of precipitated material even in undersaturated conditions. The close balance of precipitation and dissolution near equilibrium can alter the chemical composition of calcite deeper than one monolayer into the crystal. This balance of dissolution–precipitation shifts significantly toward a dissolution-dominated mechanism below about Ω= 0.7. Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate across all saturation states, and the effect is most pronounced close to equilibrium. This finding suggests that the rate of hydration of CO2 is a rate-limiting step for calcite dissolution in seawater. We then interpret our dissolution data in a framework that incorporates both solution chemistry and geometric constraints on the calcite solid. Near equilibrium, this framework demonstrates a lowered free energy barrier at the solid–solution interface in the presence of CA. This framework also indicates a significant change in dissolution mechanism at Ω= 0.7, which we interpret as the onset of homogeneous etch pit nucleation. PMID:28720698

Uranium carbide dissolution in nitric solution: Sonication vs. silent conditions

NASA Astrophysics Data System (ADS)

Virot, Matthieu; Szenknect, Stéphanie; Chave, Tony; Dacheux, Nicolas; Moisy, Philippe; Nikitenko, Sergey I.

2013-10-01

The dissolution of uranium carbide (UC) in nitric acid media is considered by means of power ultrasound (sonication) or magnetic stirring. The induction period required to initiate UC dissolution was found to be dramatically shortened when sonicating a 3 M nitric solution (Ar, 20 kHz, 18 W cm-2, 20 °C). At higher acidity, magnetic stirring offers faster dissolution kinetics compared to sonication. Ultrasound-assisted UC dissolution is found to be passivated after ∼60% dissolution and remains incomplete whatever the acidity which is confirmed by ICP-AES, LECO and SEM-EDX analyses. In general, the kinetics of UC dissolution is linked to the in situ generation of nitrous acid in agreement with the general mechanism of UC dissolution; the nitrous acid formation is reported to be faster under ultrasound at low acidity due to the nitric acid sonolysis. The carbon balance shared between the gaseous, liquid, and solid phases is strongly influenced by the applied dissolution procedure and HNO3 concentration.

Interactions between the Tetrasodium Salts of EDTA and 1-Hydroxyethane 1,1-Diphosphonic Acid with Sodium Hypochlorite Irrigants.

PubMed

Biel, Philippe; Mohn, Dirk; Attin, Thomas; Zehnder, Matthias

2017-04-01

A clinically useful all-in-one endodontic irrigant with combined proteolytic and decalcifying properties is still elusive. In this study, the chemical effects of dissolving the tetrasodium salts of 1-hydroxyethane 1,1-diphosphonic acid (Na 4 HEDP) or Na 4 EDTA directly in sodium hypochlorite (NaOCl) irrigants in polypropylene syringes were assessed during the course of 1 hour. The solubility of the salts in water was determined. Their compatibility with 1% and 5% NaOCl was measured by iodometric titration and in a calcium complexation experiment by using a Ca 2+ -selective electrode. The salts dissolved within 1 minute. The dissolution maximum of Na 4 HEDP in water (wt/total wt) was 44.6% ± 1.6%. The corresponding dissolution maximum of Na 4 EDTA was 38.2% ± 0.8%. Na 4 HEDP at 18% in 5% NaOCl caused a mere loss of 16% of the initially available chlorine during 1 hour. In contrast, a corresponding mixture between NaOCl and the Na 4 EDTA salt caused 95% reduction in available chlorine after 1 minute. Mixtures of 3% Na 4 EDTA with 1% NaOCl were more stable, but only for 30 minutes. Na 4 HEDP lost 24% of its calcium complexation capacity after 60 minutes. The corresponding loss for Na 4 EDTA was 34%. The compatibility and solubility of particulate Na 4 HEDP with/in NaOCl solutions are such that these components can be mixed and used for up to 1 hour. In contrast, short-term compatibility of the Na 4 EDTA salt with NaOCl solutions was considerably lower, decreasing at higher concentrations of either compound. Especially for Na 4 HEDP but also for Na 4 EDTA, the NaOCl had little effect on calcium complexation. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Factors Affecting the Dissolution of Indomethacin Solid Dispersions.

PubMed

Zhang, Wei; Zhang, Chen-Ning; He, Yue; Duan, Ban-Yan; Yang, Guang-Yi; Ma, Wei-Dong; Zhang, Yong-Hong

2017-11-01

The aim of this study was to investigate the influence of factors such as carrier type, drug/carrier ratio, binary carriers, and preparation method on the dissolution of an insoluble drug, indomethacin (IM), under supersaturation conditions. Using a solvent evaporation (SE) method, poloxamer 188 and PVP K30 showed better dissolution among the selected carriers. Furthermore, as the ratio of carriers increased (drug/carrier ratio from 1:0.5 to 1:2), the dissolution rate increased especially in almost two times poloxamer 188 solid dispersions (SDs), while the reverse results were observed for PVP K30 SDs. For the binary carrier SD, a lower dissolution was found. Under hot melt extrusion (HME), the dissolution of poloxamer 188 SD and PVP K30 SD was 0.83- and 0.94-folds lower than that using SE, respectively, while the binary carrier SD showed the best dissolution. For poloxamer 188 SDs, the drug's crystal form changed when using SE, while no crystal form change was observed using HME. IM was amorphous in PVP K30 SDs prepared by both methods. For binary carrier systems, amorphous and crystalline drugs coexisted in SD using SE, and negligible amorphous IM was in SD using HME. This study indicated that a higher amorphous proportion in SD did not correlate with higher dissolution rate, and other factors, such as carrier type, particle size, and density, were also critical.

A new method for evaluating the dissolution of orodispersible films.

PubMed

Xia, Yiran; Chen, Fang; Zhang, Huiping; Luo, Chunlin

2015-05-01

The aim of this research was to develop and assess a new dissolution apparatus for orodispersible films (ODFs). The new apparatus was based on a flow-through cell design which requires only a limited amount of dissolution medium and can automatically collect samples in short-time intervals. Compared with the dissolution method in Chinese Pharmacopeia, our method simulated the flow condition of the oral cavity and resulted in reproducible dissolution data and remarkably discriminating capability. Therefore, we concluded that the proposed dissolution method was particularly suitable for evaluating the dissolution of ODFs and should also be applicable to other fast-dissolving solid dosage forms.

Electrolyte-induced surface transformation and transition-metal dissolution of fully delithiated LiNi 0.8Co 0.15Al 0.05O 2

DOE PAGES

Faenza, Nicholas V.; Lebens-Higgins, Zachary W.; Mukherjee, Pinaki; ...

2017-06-08

Here, enabling practical utilization of layered Rmore » $$\\bar{3}$$ m positive electrodes near full delithiation requires an enhanced understanding of the complex electrode–electrolyte interactions that often induce failure. Using Li[Ni 0.8Co 0.15Al 0.05]O 2 (NCA) as a model layered compound, the chemical and structural stability in a strenuous thermal and electrochemical environment was explored. Operando microcalorimetry and electrochemical impedance spectroscopy identified a fingerprint for a structural decomposition and transition-metal dissolution reaction that occurs on the positive electrode at full delithiation. Surface-sensitive characterization techniques, including X-ray absorption spectroscopy and high-resolution transmission electron microscopy, measured a structural and morphological transformation of the surface and subsurface regions of NCA. Despite the bulk structural integrity being maintained, NCA surface degradation at a high state of charge induces excessive transition-metal dissolution and significant positive electrode impedance development, resulting in a rapid decrease in electrochemical performance. Additionally, the impact of electrolyte salt, positive electrode surface area, and surface Li 2CO 3 content on the magnitude and character of the dissolution reaction was studied.« less

Living in Salt: The formation and development of extremophile habitats and biosignatures within salt crusts of the hyperarid Atacama Desert

NASA Astrophysics Data System (ADS)

Finstad, K. M.; Amundson, R.

2013-12-01

It has become increasing apparent that salt-rich deposits are present on the Martian surface and that aqueous alteration has occurred sometime during the planet's past. In the hyperarid Atacama Desert in Chile, an important Earth-based analogue to Mars, microbial life has been discovered inhabiting halite (NaCl) surface crust deposits. Is it possible that similar salt deposits on Mars once harbored microbial life? If so, what adaptations were likely necessary for survival in such an environment and what biosignatures are expected to remain? Although this fascinating ecosystem in the Atacama Desert has been recognized, neither the physical processes of halite crust formation, nor the microorganisms residing within the salts have been extensively studied. To better understand the formation and geochemical dynamics of this unique habitat, we chose two sites within the Atacama Desert which exhibit both active crust formation as well as the presence of microbial communities: one site is on a dry Holocene age lake bed, while the other is of Pleistocene age. At each site soil profiles were excavated and total geochemical analyses were performed. Field observations clearly showed that the soils exhibited transitions of carbonate to sulfate to chloride salt deposition with decreasing depth, and that the thickness and mass of halite in the surficial crust was related to the age of the soil. Isotope profiles of carbon, nitrogen, and sulfur from these soils were also analyzed. Once exposed to the atmosphere, the halite crusts reside in a dynamic state of dissolution and erosion by wind and fog, and reformation due to fog and dew. In the crust nodules, microbial communities were sampled, in centimeter increments from the surface, for carbon, nitrogen, and sulfur isotope/concentration profiles. Our analyses help elucidate the physical and geochemical processes linked to the formation and evolution of these dynamic salt crusts, and the imprint of microbial life within them. A

Geology of the north end of the Salt Valley Anticline, Grand County, Utah

USGS Publications Warehouse

Gard, Leonard Meade

1976-01-01

This report describes the geology and hydrology of a portion of the Salt Valley anticline lying north of Moab, Utah, that is being studied as a potential site for underground storage of nuclear waste in salt. Selection of this area was based on recommendations made in an earlier appraisal of the potential of Paradox basin salt deposits for such use. Part of sec. 5, T. 23 S., R. 20 E. has been selected as a site for subsurface investigation as a potential repository for radioactive waste. This site has easy access to transportation, is on public land, is isolated from human habitation, is not visible from Arches National Park, and the salt body lies within about 800 feet (244 m) of the surface. Further exploration should include investigation of possible ground water in the caprock and physical exploration of the salt body to identify a thick bed of salt for use as a storage zone that can be isolated from the shaly interbeds that possibly contain quantities of hydrocarbons. Salt Valley anticline, a northwest-trending diapiric structure, consists of Mesozoic sedimentary rocks arched over a thick core of salt of the Paradox Member of the Middle Pennsylvanian Hermosa Formation. Salt began to migrate to form and/or develop this structure shortly after it was deposited, probably in response to faulting. This migration caused upwelling of the salt creating a linear positive area. This positive area, in turn, caused increased deposition of sediments in adjacent areas which further enhanced salt migration. Not until late Jurassic time had flowage of the salt slowed sufficiently to allow sediments of the Morrison and younger formations to be deposited across the salt welt. A thick cap of insoluble residue was formed on top of the salt diapir as a result of salt dissolution through time. The crest of the anticline is breached; it collapsed in two stages during the Tertiary Period. The first stage was graben collapse during the early Tertiary; the second stage occurred after

Short-time dissolution mechanisms of kaolinitic tropical soils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malengreau, N.; Sposito, Garrison

1996-03-01

Previous research on the short-time dissolution behavior of kaolinitic Oxisols suggested pH-dependent kinetics involving ligand-promoted dissolution, metal readsorption, and colloidal dispersion, with soil organic matter conjectured to play a decisive role. A novel combination of spectroscopy, lightscattering, and batch dissolution experiments, conducted at controlled pH and ionic strength over five dissolution periods ranging from 1 to 12 h, was applied to evaluate this mechanism for samples of a representative kaolinitic Oxisol; collected at both forested and cultivated field sites (leading to significant differences in organic matter content and field soil pH). The overall characteristics of the pH-dependent net release kineticsmore » of Al, Fe, and Si by the soil samples, for any dissolution period in the range investigated, were determined by the pH value at which colloid dispersion commenced, which decreased significantly as the soil organic matter content increased. Plots of log(Si/Al released) (or Si/Fe released) vs. -log [H+] ([H+] is proton concentration) were superimposable for all dissolution periods studied, rising to a plateau value above the point of zero net charge of the soils (pH 3.2). Light-scattering and X-ray diffraction data showed conclusively that this plateau represented the release of siliceous colloids containing kaolinite and X-ray amorphous material. X-ray diffraction, UV-visible diffuse reflectance spectroscopy, and electron spin resonance spectroscopy, applied to the soil samples before and after dissolution, and after conventional chemical extractions to remove Al, C, Fe, and Si, showed that kaolinite and iron oxide phases (the latter being highly Al-substituted and present in both coatings and occlusions) were essentially unaltered by dissolution, even at -log [H+] = 2, whereas substantial dissolution loss of soil quartz occurred. Diffuse reflectance spectroscopy gave strong evidence that C in these soils occurs principally in

Exploring How Different Features of Animations of Sodium Chloride Dissolution Affect Students' Explanations

NASA Astrophysics Data System (ADS)

Kelly, Resa M.; Jones, Loretta L.

2007-10-01

Animations of molecular structure and dynamics are often used to help students understand the abstract ideas of chemistry. This qualitative study investigated how the features of two different styles of molecular-level animation affected students' explanations of how sodium chloride dissolves in water. In small group sessions 18 college-level general chemistry students dissolved table salt in water, after which they individually viewed two animations of salt dissolution. Before and after viewing each animation the participants provided pictorial, written, and oral explanations of the process at the macroscopic and molecular levels. The students then discussed the animations as a group. An analysis of the data showed that students incorporated some of the microscopic structural and functional features from the animations into their explanations. However, oral explanations revealed that in many cases, participants who drew or wrote correct explanations did not comprehend their meanings. Students' drawings may have reflected only what they had seen, rather than a cohesive understanding. Students' explanations given after viewing the animations improved, but some prior misconceptions were retained and in some cases, new misconceptions appeared. Students reported that they found the animations useful in learning; however, they sometimes missed essential features when they watched the animation alone.

Etching of semiconductor cubic crystals: Determination of the dissolution slowness surfaces

NASA Astrophysics Data System (ADS)

Tellier, C. R.

1990-03-01

Equations of the representative surface of dissolution slowness for cubic crystals are determined in the framework of a tensorial approach of the orientation-dependent etching process. The independent dissolution constants are deduced from symmetry considerations. Using previous data on the chemical etching of germanium and gallium arsenide crystals, some possible polar diagrams of the dissolution slowness are proposed. A numerical and graphical simulation method is used to obtain the derived dissolution shapes. The influence of extrema in the dissolution slowness on the successive dissolution shapes is also examined. A graphical construction of limiting shapes of etched crystals appears possible using the tensorial representation of the dissolution slowness.

Comparison and analysis of theoretical models for diffusion-controlled dissolution.

PubMed

Wang, Yanxing; Abrahamsson, Bertil; Lindfors, Lennart; Brasseur, James G

2012-05-07

Dissolution models require, at their core, an accurate diffusion model. The accuracy of the model for diffusion-dominated dissolution is particularly important with the trend toward micro- and nanoscale drug particles. Often such models are based on the concept of a "diffusion layer." Here a framework is developed for diffusion-dominated dissolution models, and we discuss the inadequacy of classical models that are based on an unphysical constant diffusion layer thickness assumption, or do not correctly modify dissolution rate due to "confinement effects": (1) the increase in bulk concentration from confinement of the dissolution process, (2) the modification of the flux model (the Sherwood number) by confinement. We derive the exact mathematical solution for a spherical particle in a confined fluid with impermeable boundaries. Using this solution, we analyze the accuracy of a time-dependent "infinite domain model" (IDM) and "quasi steady-state model" (QSM), both formally derived for infinite domains but which can be applied in approximate fashion to confined dissolution with proper adjustment of a concentration parameter. We show that dissolution rate is sensitive to the degree of confinement or, equivalently, to the total concentration C(tot). The most practical model, the QSM, is shown to be very accurate for most applications and, consequently, can be used with confidence in design-level dissolution models so long as confinement is accurately treated. The QSM predicts the ratio of diffusion layer thickness to particle radius (the Sherwood number) as a constant plus a correction that depends on the degree of confinement. The QSM also predicts that the time required for complete saturation or dissolution in diffusion-controlled dissolution experiments is singular (i.e., infinite) when total concentration equals the solubility. Using the QSM, we show that measured differences in dissolution rate in a diffusion-controlled dissolution experiment are a result of

Convective dissolution of carbon dioxide in saline aquifers

NASA Astrophysics Data System (ADS)

Neufeld, Jerome A.; Hesse, Marc A.; Riaz, Amir; Hallworth, Mark A.; Tchelepi, Hamdi A.; Huppert, Herbert E.

2010-11-01

Geological carbon dioxide (CO2) storage is a means of reducing anthropogenic emissions. Dissolution of CO2 into the brine, resulting in stable stratification, increases storage security. The dissolution rate is determined by convection in the brine driven by the increase of brine density with CO2 saturation. We present a new analogue fluid system that reproduces the convective behaviour of CO2-enriched brine. Laboratory experiments and high-resolution numerical simulations show that the convective flux scales with the Rayleigh number to the 4/5 power, in contrast with a classical linear relationship. A scaling argument for the convective flux incorporating lateral diffusion from downwelling plumes explains this nonlinear relationship for the convective flux, provides a physical picture of high Rayleigh number convection in a porous medium, and predicts the CO2 dissolution rates in CO2 accumulations. These estimates of the dissolution rate show that convective dissolution can play an important role in enhancing storage security.

Chemical Dissolution of Simulant FCA Cladding and Plates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel, G.; Pierce, R.; O'Rourke, P.

The Savannah River Site (SRS) has received some fast critical assembly (FCA) fuel from the Japan Atomic Energy Agency (JAEA) for disposition. Among the JAEA FCA fuel are approximately 7090 rectangular Stainless Steel clad fuel elements. Each element has an internal Pu-10.6Al alloy metal wafer. The thickness of each element is either 1/16 inch or 1/32 inch. The dimensions of each element ranges from 2 inches x 1 inch to 2 inches x 4 inches. This report discusses the potential chemical dissolution of the FCA clad material or stainless steel. This technology uses nitric acid-potassium fluoride (HNO 3-KF) flowsheets ofmore » H-Canyon to dissolve the FCA elements from a rack of materials. Historically, dissolution flowsheets have aimed to maximize Pu dissolution rates while minimizing stainless steel dissolution (corrosion) rates. Because the FCA cladding is made of stainless steel, this work sought to accelerate stainless steel dissolution.« less

Montmorillonite dissolution kinetics: Experimental and reactive transport modeling interpretation

NASA Astrophysics Data System (ADS)

Cappelli, Chiara; Yokoyama, Shingo; Cama, Jordi; Huertas, F. Javier

2018-04-01

The dissolution kinetics of K-montmorillonite was studied at 25 °C, acidic pH (2-4) and 0.01 M ionic strength by means of well-mixed flow-through experiments. The variations of Si, Al and Mg over time resulted in high releases of Si and Mg and Al deficit, which yielded long periods of incongruent dissolution before reaching stoichiometric steady state. This behavior was caused by simultaneous dissolution of nanoparticles and cation exchange between the interlayer K and released Ca, Mg and Al and H. Since Si was only involved in the dissolution reaction, it was used to calculate steady-state dissolution rates, RSi, over a wide solution saturation state (ΔGr ranged from -5 to -40 kcal mol-1). The effects of pH and the degree of undersaturation (ΔGr) on the K-montmorillonite dissolution rate were determined using RSi. Employing dissolution rates farthest from equilibrium, the catalytic pH effect on the K-montmorillonite dissolution rate was expressed as Rdiss = k·aH0.56±0.05 whereas using all dissolution rates, the ΔGr effect was expressed as a non-linear f(ΔGr) function Rdiss = k · [1 - exp(-3.8 × 10-4 · (|ΔGr|/RT)2.13)] The functionality of this expression is similar to the equations reported for dissolution of Na-montmorillonite at pH 3 and 50 °C (Metz, 2001) and Na-K-Ca-montmorillonite at pH 9 and 80 °C (Cama et al., 2000; Marty et al., 2011), which lends support to the use of a single f(ΔGr) term to calculate the rate over the pH range 0-14. Thus, we propose a rate law that also accounts for the effect of pOH and temperature by using the pOH-rate dependence and the apparent activation energy proposed by Rozalén et al. (2008) and Amram and Ganor (2005), respectively, and normalizing the dissolution rate constant with the edge surface area of the K-montmorillonite. 1D reactive transport simulations of the experimental data were performed using the Crunchflow code (Steefel et al., 2015) to quantitatively interpret the evolution of the released cations

Salt

USGS Publications Warehouse

Franson, J.C.; Friend, M.

1999-01-01

Animals become victims of salt poisoning or toxicosis when toxic levels of sodium and chloride accumulate in the blood after they ingest large amounts of salt or, in some species, are deprived of water. For birds, salt sources may include saline water and road salt.Normally, the salt glands of birds (Fig. 47.1) excrete sodium and chloride to maintain the proper physiologic chemical balance. However, when there has been insufficient time for acclimation of the salt gland to the saline environment, or when salt gland function is compromised by exposure to certain pesticides or oil, the electrolyte balance of the blood may be upset by the excess sodium and chloride, resulting in toxicosis. Salt accumulation on the outside of the body, or salt encrustation, is a greater problem for waterbirds that use very saline waters than is salt toxicosis. Salt encrustation can lead to exertion, acute muscle degeneration, and eventual drowning during the struggle to escape entrapment.

Dissolution Flowsheet for High Flux Isotope Reactor Fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniel, W. E.; Rudisill, T. S.; O'Rourke, P. E.

2016-09-27

As part of the Spent Nuclear Fuel (SNF) processing campaign, H-Canyon is planning to begin dissolving High Flux Isotope Reactor (HFIR) fuel in late FY17 or early FY18. Each HFIR fuel core contains inner and outer fuel elements which were fabricated from uranium oxide (U 3O 8) dispersed in a continuous Al phase using traditional powder metallurgy techniques. Fuels fabricated in this manner, like other SNF’s processed in H-Canyon, dissolve by the same general mechanisms with similar gas generation rates and the production of H 2. The HFIR fuel cores will be dissolved and the recovered U will be down-blendedmore » into low-enriched U. HFIR fuel was previously processed in H-Canyon using a unique insert in both the 6.1D and 6.4D dissolvers. Multiple cores will be charged to the same dissolver solution maximizing the concentration of dissolved Al. The objective of this study was to identify flowsheet conditions through literature review and laboratory experimentation to safely and efficiently dissolve the HFIR fuel in H-Canyon. Laboratory-scale experiments were performed to evaluate the dissolution of HFIR fuel using both Al 1100 and Al 6061 T6 alloy coupons. The Al 1100 alloy was considered a representative surrogate which provided an upper bound on the generation of flammable (i.e., H 2) gas during the dissolution process. The dissolution of the Al 6061 T6 alloy proceeded at a slower rate than the Al 1100 alloy, and was used to verify that the target Al concentration in solution could be achieved for the selected Hg concentration. Mass spectrometry and Raman spectroscopy were used to provide continuous monitoring of the concentration of H 2 and other permanent gases in the dissolution offgas, allowing the development of H 2 generation rate profiles. The H 2 generation rates were subsequently used to evaluate if a full HFIR core could be dissolved in an H-Canyon dissolver without exceeding 60% of the calculated lower flammability limit (LFL) for H 2 at a given Hg

CALCIUM CARBONATE DISSOLUTION RATE IN LIMESTONE CONTACTORS

EPA Science Inventory

The rate of carbonate mineral dissolution from limestone was studied using a rotating disk apparatus and samples of limestone of varied composition. The purpose of this study was to determine the effect of limestone composition on the kinetics of carbonate mineral dissolution. Th...

Emotional and Cognitive Coping in Relationship Dissolution

ERIC Educational Resources Information Center

Wrape, Elizabeth R.; Jenkins, Sharon Rae; Callahan, Jennifer L.; Nowlin, Rachel B.

2016-01-01

Dissolution of a romantic relationship can adversely affect functioning among college students and represents one primary reason for seeking campus counseling. This study examined the associations among common coping strategies and distress following relationship dissolution. Avoidance and repetitive negative thinking (RNT) were significantly…

Sulphate removal from sodium sulphate-rich brine and recovery of barium as a barium salt mixture.

PubMed

Vadapalli, Viswanath R K; Zvimba, John N; Mulopo, Jean; Motaung, Solly

2013-01-01

Sulphate removal from sodium sulphate-rich brine using barium hydroxide and recovery of the barium salts has been investigated. The sodium sulphate-rich brine treated with different dosages of barium hydroxide to precipitate barium sulphate showed sulphate removal from 13.5 g/L to less than 400 mg/L over 60 min using a barium to sulphate molar ratio of 1.1. The thermal conversion of precipitated barium sulphate to barium sulphide achieved a conversion yield of 85% using coal as both a reducing agent and an energy source. The recovery of a pure mixture of barium salts from barium sulphide, which involved dissolution of barium sulphide and reaction with ammonium hydroxide resulted in recovery of a mixture of barium carbonate (62%) and barium hydroxide (38%), which is a critical input raw material for barium salts based acid mine drainage (AMD) desalination technologies. Under alkaline conditions of this barium salt mixture recovery process, ammonia gas is given off, while hydrogen sulfide is retained in solution as bisulfide species, and this provides basis for ammonium hydroxide separation and recovery for reuse, with hydrogen sulfide also recoverable for further industrial applications such as sulfur production by subsequent stripping.

12 CFR 710.8 - Certificate of dissolution and liquidation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Certificate of dissolution and liquidation. 710... UNIONS VOLUNTARY LIQUIDATION § 710.8 Certificate of dissolution and liquidation. Within 120 days after the final distribution of assets to members is started, a duly executed Certificate of Dissolution and...

12 CFR 710.8 - Certificate of dissolution and liquidation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Certificate of dissolution and liquidation. 710... UNIONS VOLUNTARY LIQUIDATION § 710.8 Certificate of dissolution and liquidation. Within 120 days after the final distribution of assets to members is started, a duly executed Certificate of Dissolution and...

12 CFR 710.8 - Certificate of dissolution and liquidation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Certificate of dissolution and liquidation. 710... UNIONS VOLUNTARY LIQUIDATION § 710.8 Certificate of dissolution and liquidation. Within 120 days after the final distribution of assets to members is started, a duly executed Certificate of Dissolution and...

12 CFR 710.8 - Certificate of dissolution and liquidation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Certificate of dissolution and liquidation. 710... UNIONS VOLUNTARY LIQUIDATION § 710.8 Certificate of dissolution and liquidation. Within 120 days after the final distribution of assets to members is started, a duly executed Certificate of Dissolution and...

12 CFR 710.8 - Certificate of dissolution and liquidation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Certificate of dissolution and liquidation. 710... UNIONS VOLUNTARY LIQUIDATION § 710.8 Certificate of dissolution and liquidation. Within 120 days after the final distribution of assets to members is started, a duly executed Certificate of Dissolution and...

Does the dose-solubility ratio affect the mean dissolution time of drugs?

PubMed

Lánský, P; Weiss, M

1999-09-01

To present a new model for describing drug dissolution. On the basis of the new model to characterize the dissolution profile by the distribution function of the random dissolution time of a drug molecule, which generalizes the classical first order model. Instead of assuming a constant fractional dissolution rate, as in the classical model, it is considered that the fractional dissolution rate is a decreasing function of the dissolved amount controlled by the dose-solubility ratio. The differential equation derived from this assumption is solved and the distribution measures (half-dissolution time, mean dissolution time, relative dispersion of the dissolution time, dissolution time density, and fractional dissolution rate) are calculated. Finally, instead of monotonically decreasing the fractional dissolution rate, a generalization resulting in zero dissolution rate at time origin is introduced. The behavior of the model is divided into two regions defined by q, the ratio of the dose to the solubility level: q < 1 (complete dissolution of the dose, dissolution time) and q > 1 (saturation of the solution, saturation time). The singular case q = 1 is also treated and in this situation the mean as well as the relative dispersion of the dissolution time increase to infinity. The model was successfully fitted to data (1). This empirical model is descriptive without detailed physical reasoning behind its derivation. According to the model, the mean dissolution time is affected by the dose-solubility ratio. Although this prediction appears to be in accordance with preliminary application, further validation based on more suitable experimental data is required.

Observations of magnetite dissolution in poorly drained soils

USGS Publications Warehouse

Grimley, D.A.; Arruda, N.K.

2007-01-01

Dissolution of strongly magnetic minerals is a common and relatively rapid phenomenon in poorly drained soils of the central United States, resulting in low magnetic susceptibility (MS). Low Eh reducing conditions are primarily responsible for magnetic mineral dissolution; a process likely mediated by iron-reducing bacteria in the presence of soil organic matter. Based on transects across drainage sequences from nine sites, natural magnetic minerals (>5 ??m) extracted from surface soil consist of 54% ?? 18% magnetite, 21% ?? 11% titanomagnetite, and 17% ?? 14% ilmenite. Magnetite and titanomagnetite dissolution, assessed by scanning electron microscopy on a 0-to-3 scale, inversely correlates with surface soil MS (r = 0.53), a proxy for soil drainage at studied transects. Altered magnetite typically displays etch pits 5 ??m) include 26% ?? 18% anthropogenic fly ash that also exhibits greater dissolution in low MS soils (r = 0.38), indicating detectable alteration can occur within 150 years in low Eh soils. Laboratory induced reduction of magnetite, titanomagnetite, and magnetic fly ash, with a citrate-bicarbonate- dithionite solution, resulted in dissolution textures similar to those of in situ soil particles. Although experiments indicate that reductive dissolution of magnetite can occur abiotically under extreme conditions, bacteria likely play an important role in the natural environment. ?? 2007 Lippincott Williams & Wilkins, Inc.

Synergistic effect of reductive and ligand-promoted dissolution of goethite.

PubMed

Wang, Zimeng; Schenkeveld, Walter D C; Kraemer, Stephan M; Giammar, Daniel E

2015-06-16

Ligand-promoted dissolution and reductive dissolution of iron (hydr)oxide minerals control the bioavailability of iron in many environmental systems and have been recognized as biological iron acquisition strategies. This study investigated the potential synergism between ligands (desferrioxamine B (DFOB) or N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED)) and a reductant (ascorbate) in goethite dissolution. Batch experiments were performed at pH 6 with ligand or reductant alone and in combination, and under both oxic and anoxic conditions. Goethite dissolution in the presence of reductant or ligand alone followed classic surface-controlled dissolution kinetics. Ascorbate alone does not promote goethite dissolution under oxic conditions due to rapid reoxidation of Fe(II). The rate coefficients for goethite dissolution by ligands are closely correlated with the stability constants of the aqueous Fe(III)-ligand complexes. A synergistic effect of DFOB and ascorbate on the rate of goethite dissolution was observed (total rates greater than the sum of the individual rates), and this effect was most pronounced under oxic conditions. For HBED, macroscopically the synergistic effect was hidden due to the inhibitory effect of ascorbate on HBED adsorption. After accounting for the concentrations of adsorbed ascorbate and HBED, a synergistic effect could still be identified. The potential synergism between ligand and reductant for iron (hydr)oxide dissolution may have important implications for iron bioavailability in soil environments.

Chemical stability of Lithium 2-trifluoromethyl-4,5-dicyanoimidazolide, an electrolyte salt for Li-ion cells

DOE PAGES

Shkrob, Ilya A.; Pupek, Krzysztof Z.; Gilbert, James A.; ...

2016-12-01

Lithium hexafluorophosphate (LiPF 6) is ubiquitous in commercial lithium-ion batteries, but it is hydrolytically unstable and corrosive on electrode surfaces. Using a more stable salt would confer multiple benefits for high-voltage operation, but many such electrolyte systems facilitate anodic dissolution and pitting corrosion of aluminum current collectors that negate their advantages. Lithium 2-trifluoromethyl-4,5-dicyanoimidazolide (LiTDI) is a new salt that was designed specifically for high-voltage cells. In this study we demonstrate that in carbonate electrolytes, LiTDI prevents anodic dissolution of Al current collectors, which places it into a select group of corrosion inhibitors. However, we also demonstrate that LiTDI becomes reducedmore » on lithiated graphite, undergoing sequential defluorination and yielding a thick and resistive solid-electrolyte interphase (SEI), which increases impedance and lowers electrode capacity. The mechanistic causes for this behavior are examined using computational chemistry methods in the light of recent spectroscopic studies. Here, we demonstrate that LiTDI reduction can be prevented by certain electrolyte additives, which include fluoroethylene carbonate, vinylene carbonate and lithium bis(oxalato)borate. This beneficial action is due to preferential reduction of these additives over LiTDI at a higher potential vs. Li/Li +, so the resulting SEI can prevent the direct reduction of LiTDI at lower potentials on the graphite electrode.« less

Surface subsidence and collapse in relation to extraction of salt and other soluble evaporites

USGS Publications Warehouse

Ege, John R.

1979-01-01

Extraction of soluble minerals, whether by natural or man-induced processes, can result in localized land-surface subsidence and more rarely sinkhole formation. One process cited by many investigators is that uncontrolled dissolving of salt or other soluble evaporites can create or enlarge underground cavities, thereby increasing the span of the unsupported roof to the strength limit of the overlying rocks. Downwarping results when spans are exceeded, or collapse of the undermined roof leads to upward sloping or chimneying of the overburden rocks. If underground space is available for rock debris to collect, the void can migrate to the surface with the end result being surface subsidence or collapse. In North America natural solution subsidence and collapse features in rocks ranging in age from Silurian to the present are found in evaporite terranes in the Great Plains from Saskatchewan in the north to Texas and New Mexico in the south, in the Great Lakes area, and in the southeastern States. Man-induced subsidence and collapse in evaporites are generally associated with conventional or solution mining, oilfield operations, and reservoir and dam construction, and can be especially hazardous in populated or built-up areas.

Nonaqueous Phase Liquid Dissolution in Porous Media: Multi-Scale Effects of Multi-Component Dissolution Kinetics on Cleanup Time

DOE Office of Scientific and Technical Information (OSTI.GOV)

McNab, W; Ezzedine, S; Detwiler, R

2007-02-26

Industrial organic solvents such as trichloroethylene (TCE) and tetrachloroethylene (PCE) constitute a principal class of groundwater contaminants. Cleanup of groundwater plume source areas associated with these compounds is problematic, in part, because the compounds often exist in the subsurface as dense nonaqueous phase liquids (DNAPLs). Ganglia (or 'blobs') of DNAPL serve as persistent sources of contaminants that are difficult to locate and remediate (e.g. Fenwick and Blunt, 1998). Current understanding of the physical and chemical processes associated with dissolution of DNAPLs in the subsurface is incomplete and yet is critical for evaluating long-term behavior of contaminant migration, groundwater cleanup, andmore » the efficacy of source area cleanup technologies. As such, a goal of this project has been to contribute to this critical understanding by investigating the multi-phase, multi-component physics of DNAPL dissolution using state-of-the-art experimental and computational techniques. Through this research, we have explored efficient and accurate conceptual and numerical models for source area contaminant transport that can be used to better inform the modeling of source area contaminants, including those at the LLNL Superfund sites, to re-evaluate existing remediation technologies, and to inspire or develop new remediation strategies. The problem of DNAPL dissolution in natural porous media must be viewed in the context of several scales (Khachikian and Harmon, 2000), including the microscopic level at which capillary forces, viscous forces, and gravity/buoyancy forces are manifested at the scale of individual pores (Wilson and Conrad, 1984; Chatzis et al., 1988), the mesoscale where dissolution rates are strongly influenced by the local hydrodynamics, and the field-scale. Historically, the physico-chemical processes associated with DNAPL dissolution have been addressed through the use of lumped mass transfer coefficients which attempt to quantify

Dissolution of covalent adaptable network polymers in organic solvent

NASA Astrophysics Data System (ADS)

Yu, Kai; Yang, Hua; Dao, Binh H.; Shi, Qian; Yakacki, Christopher M.

2017-12-01

It was recently reported that thermosetting polymers can be fully dissolved in a proper organic solvent utilizing a bond-exchange reaction (BER), where small molecules diffuse into the polymer, break the long polymer chains into short segments, and eventually dissolve the network when sufficient solvent is provided. The solvent-assisted dissolution approach was applied to fully recycle thermosets and their fiber composites. This paper presents the first multi-scale modeling framework to predict the dissolution kinetics and mechanics of thermosets in organic solvent. The model connects the micro-scale network dynamics with macro-scale material properties: in the micro-scale, a model is developed based on the kinetics of BERs to describe the cleavage rate of polymer chains and evolution of chain segment length during the dissolution. The micro-scale model is then fed into a continuum-level model with considerations of the transportation of solvent molecules and chain segments in the system. The model shows good prediction on conversion rate of functional groups, degradation of network mechanical properties, and dissolution rate of thermosets during the dissolution. It identifies the underlying kinetic factors governing the dissolution process, and reveals the influence of different material and processing variables on the dissolution process, such as time, temperature, catalyst concentration, and chain length between cross-links.

What controls silicon isotope fractionation during dissolution of diatom opal?

NASA Astrophysics Data System (ADS)

Wetzel, F.; de Souza, G. F.; Reynolds, B. C.

2014-04-01

The silicon isotope composition of opal frustules from photosynthesising diatoms is a promising tool for studying past changes in the marine silicon cycle, and indirectly that of carbon. Dissolution of this opal may be accompanied by silicon isotope fractionation that could disturb the pristine silicon isotope composition of diatom opal acquired in the surface ocean. It has previously been shown that dissolution of fresh and sediment trap diatom opal in seawater does fractionate silicon isotopes. However, as the mechanism of silicon isotope fractionation remained elusive, it is uncertain whether opal dissolution in general is associated with silicon isotope fractionation considering that opal chemistry and surface properties are spatially and temporally (i.e. opal of different age) diverse. In this study we dissolved sediment core diatom opal in 5 mM NaOH and found that this process is not associated with significant silicon isotope fractionation. Since no variability of the isotope effect was observed over a wide range of dissolution rates, we can rule out the suggestion that back-reactions had a significant influence on the net isotope effect. Similarly, we did not observe an impact of temperature, specific surface area, or degree of undersaturation on silicon isotope partitioning during dissolution, such that these can most likely also be ruled out as controlling factors. We discuss the potential impacts of the chemical composition of the dissolution medium and age of diatom opal on silicon isotope fractionation during dissolution. It appears most likely that the controlling mechanism of silicon isotope fractionation during dissolution is related to the reactivity, or potentially, aluminium content of the opal. Such a dependency would imply that silicon isotope fractionation during dissolution of diatom opal is spatially and temporally variable. However, since the isotope effects during dissolution are small, the silicon isotope composition of diatom opal

Geology and evolution of lakes in north-central Florida

USGS Publications Warehouse

Kindinger, J.L.; Davis, J.B.; Flocks, J.G.

1999-01-01

Fluid exchange between surficial waters and groundwater in karst environments, and the processes that control exchange, are of critical concern to water management districts and planners. High-resolution seismic data were collected from 30 lakes of north-central Florida. In each case study, lake structure and geomorphology were controlled by solution and/or mechanical processes. Processes that control lake development are twofold: (1) karstification or dissolution of the underlying limestone, and (2) the collapse, subsidence, or slumping of overburden to form sinkholes. Initial lake formation is directly related to the karst topography of the underlying host limestone. Case studies have shown that lakes can be divided by geomorphic types into progressive developmental phases: (1) active subsidence or collapse phase (young); (2) transitional phase (middle age); (3) baselevel phase (mature); and (4) polje (drowned prairie) - broad flat-bottom that have one or all phases of sinkhole. Using these criteria, Florida lakes can be classified by size, fill, subsurface features, and geomorphology.Fluid exchange between surficial waters and groundwater in karst environments, and the processes that control exchange, are of critical concern to water management districts and planners. High-resolution seismic data were collected from 30 lakes of north-central Florida. In each case study, lake structure and geomorphology were controlled by solution and/or mechanical processes. Processes that control lake development are twofold: (1) karstification or dissolution of the underlying limestone, and (2) the collapse, subsidence, or slumping of overburden to form sinkholes. Initial lake formation is directly related to the karst topography of the underlying host limestone. Case studies have shown that lakes can be divided by geomorphic types into progressive developmental phased: (1) active subsidence or collapse phase (young); (2) transitional phase (middle age); (3) baselevel phase

Evaluation of extemporaneous oral itraconazole suspensions by dissolution profiles mapping.

PubMed

Tong, Henry H Y; Chan, Hokman; Du, Zhen; Zheng, Ying

2010-01-01

The objective of this study was to evaluate by dissolution profiles mapping five extemporaneous oral itraconazole suspensions reported in the literature. Dissolution profiles of the extemporaneous oral itraconazole preparations were mapped and correlated with their reported clinical data therein. Four out of five extemporaneous preparations had either too early or insufficient release of itraconazole during the dissolution study, potentially limiting the in vivo oral bioavailability in patients. Dissolution profiles in the remaining extemporaneous preparation was closely similar to that in commercial itraconazole capsules. Based on the reported clinical data and dissolution results in this study, the extemporaneous preparation proposed in a study by Ong and Fobes seems to be the most reasonable choice for our patients. Dissolution profile evaluation is an important quality-control parameter during the evaluation of extemporaneous preparations by pharmacists.

Dissolution and Separation of Aluminum and Aluminosilicates

DOE PAGES

McFarlane, Joanna; Benker, Dennis; DePaoli, David W.; ...

2015-12-19

The selection of an aluminum alloy for target irradiation affects post-irradiation target dissolution and separations. Recent tests with aluminum alloy 6061 yielded greater than expected precipitation in the dissolver, forming up to 10 wt.% solids of aluminum hydroxides and aluminosilicates. Aluminosilicate dissolution presents challenges in a number of different areas, metals extraction from minerals, flyash treatment, and separations from aluminum alloys. We present experimental work that attempts to maximize dissolution of aluminum metal, along with silicon, magnesium, and copper impurities, through control of temperature, the rate of reagent addition, and incubation time. Aluminum phase transformations have been identified as amore » function of time and temperature, using X-ray diffraction. Solutions have been analyzed using wet chemical methods and X-ray fluorescence. Our data have been compared with published calculations of aluminum phase diagrams. Approaches are given to enhance the dissolution of aluminum and aluminosilicate phases in caustic solution.« less

Kinetics of Inorganic Calcite Dissolution in Seawater under Pressure

NASA Astrophysics Data System (ADS)

Dong, S.; Subhas, A.; Rollins, N.; Berelson, W.; Adkins, J. F.

2016-02-01

While understanding calcium carbonate dissolution is vital in constructing global carbon cycles and predicting the effect of seawater acidification as a result of increasing atmospheric CO2, there is still a major debate over the basic formulation of a dissolution rate law. The kinetics of calcium carbonate dissolution are typically described by the equation: Rate=k(1-Ω)n, while Ω=[Ca2+][CO32-]/Ksp. In this study, 13C-labeled calcite is dissolved in unlabeled seawater and the evolving d13C composition of the fluid is traced over time to establish dissolution rate. Instead of changing ion concentration to obtain varying Ω (as in our previous study; Subhas et al. 2015), we changed Ksp by conducting experiments under different pressures (described in theory as ∂lnKsp/∂P=-ΔV/RT, where ΔV is partial molal volume). This involved the construction of a pressure vessel that could hold our sample bag and provide aliquots while remaining pressurized. Pressure experiments were conducted between 0-2000PSI. Results support the conclusion in our previous study that near-equilibrium dissolution rates are highly nonlinear, but give a disparate relationship between undersaturation and dissolution rate if Ω is calculated assuming the specific ΔV embedded in CO2SYS. A revised ΔV from -37cm3 to -65cm3 would make the dissolution formulation equation agree, but clearly appears unreasonable. Our results are explained by a pressure effect on carbonate dissolution kinetics over and above the influence of pressure on Ω. If this is a phenomenon that occurs in nature, then we would predict that dissolution should be occurring shallower in the water column (as sometimes observed) than indicated by standard Ω calculations.

General solution for diffusion-controlled dissolution of spherical particles. 1. Theory.

PubMed

Wang, J; Flanagan, D R

1999-07-01

Three classical particle dissolution rate expressions are commonly used to interpret particle dissolution rate phenomena. Our analysis shows that an assumption used in the derivation of the traditional cube-root law may not be accurate under all conditions for diffusion-controlled particle dissolution. Mathematical analysis shows that the three classical particle dissolution rate expressions are approximate solutions to a general diffusion layer model. The cube-root law is most appropriate when particle size is much larger than the diffusion layer thickness, the two-thirds-root expression applies when the particle size is much smaller than the diffusion layer thickness. The square-root expression is intermediate between these two models. A general solution to the diffusion layer model for monodispersed spherical particles dissolution was derived for sink and nonsink conditions. Constant diffusion layer thickness was assumed in the derivation. Simulated dissolution data showed that the ratio between particle size and diffusion layer thickness (a0/h) is an important factor in controlling the shape of particle dissolution profiles. A new semiempirical general particle dissolution equation is also discussed which encompasses the three classical particle dissolution expressions. The success of the general equation in explaining limitations of traditional particle dissolution expressions demonstrates the usefulness of the general diffusion layer model.

Interface dissolution control of the 14C profile in marine sediment

USGS Publications Warehouse

Keir, R.S.; Michel, R.L.

1993-01-01

The process of carbonate dissolution at the sediment-water interface has two possible endmember boundary conditions. Either the carbonate particles dissolve mostly before they are incorporated into the sediment by bioturbation (interface dissolution), or the vertical mixing is rapid relative to their extermination rate (homogeneous dissolution). In this study, a detailed radiocarbon profile was determined in deep equatorial Pacific sediment that receives a high rate of carbonate supply. In addition, a box model of sediment mixing was used to simulate radiocarbon, carbonate content and excess thorium profiles that result from either boundary process following a dissolution increase. Results from homogeneous dissolution imply a strong, very recent erosional event, while interface dissolution suggests that moderately increased dissolution began about 10,000 years ago. In order to achieve the observed mixed layer radiocarbon age, increased homogeneous dissolution would concentrate a greater amount of clay and 230Th than is observed, while for interface dissolution the predicted concentrations are too small. These results together with small discontinuities beneath the mixed layer in 230Th profiles suggest a two-stage increase in interface dissolution in the deep Pacific, the first occurring near the beginning of the Holocene and the second more recently, roughly 5000 years ago. ?? 1993.

Preparation of Al-La Master Alloy by Thermite Reaction in NaF-NaCl-KCl Molten Salt

NASA Astrophysics Data System (ADS)

Jang, Poknam; Li, Hyonmo; Kim, Wenjae; Wang, Zhaowen; Liu, Fengguo

2015-05-01

A NaF-NaCl-KCl ternary system containing La2O3 was investigated for the preparation of Al-La master alloy by the thermite reaction method. The solubility of La2O3 in NaF-NaCl-KCl molten salt was determined by the method of isothermal solution saturation. Inductively coupled plasma-optical emission spectroscopy and x-ray diffraction (XRD) analyses were used to consider the content of La2O3 in molten salt and the supernatant composition of molten salt after dissolution of La2O3, respectively. The results showed that the content of NaF had a positive influence on the solubility of La2O3 in NaF-NaCl-KCl molten salts, and the solubility of La2O3 could reach 8.71 wt.% in molten salts of 50 wt.%NaF-50 wt.% (44 wt.%NaCl + 56 wt.%KCl). The XRD pattern of cooling molten salt indicated the formation of LaOF in molten salt, which was probably obtained by the reaction between NaF and La2O3. The kinetic study showed that the thermite reaction was in accord with a first-order reaction model. The main influence factors on La content in the Al-La master alloy product, including molten salt composition, amount of Al, concentration of La2O3, stirring, reduction time and temperature, were investigated by single-factor experimentation. The content of La in the Al-La master alloy could be reached to 10.1 wt.%.

50 CFR 270.23 - Dissolution of Councils.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Dissolution of Councils. 270.23 Section 270.23 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.23 Dissolution of Councils. (a) Petition for termination. (1) A petition to terminate a Council...

50 CFR 270.23 - Dissolution of Councils.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Dissolution of Councils. 270.23 Section 270.23 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.23 Dissolution of Councils. (a) Petition for termination. (1) A petition to terminate a Council...