28 CFR 2.219 - Maximum terms of imprisonment and supervised release.

Code of Federal Regulations, 2010 CFR

2010-07-01

... other than above (e.g., marijuana/hashish), or schedule III drugs 3 years 2 years. If schedule IV drugs... PCP 5 years 3 years. If schedule I or II drugs other than above (e.g., marijuana, hashish....g., marijuana, hashish), or schedule III or IV drugs 3 years 2 years. If schedule V drugs 3 years 1...

An Investigation into the Effect of the Mode of Presentation on Contract Evaluation When Cost/Schedule Control System Criteria Is Used.

DTIC Science & Technology

1986-09-01

inversely related to years of experience. 1 18 IV. Methodology The methods used to test the research hypotheses were experimentation and survey. Two test...17 IV. Methodology .. .. .. .. .. .. .. ... .. ... .. .... 19 Task. .. .. .. .. .. .. ... .. ... .. ... .... 19 Population...Attribute Ratings vs Mode of Presentation (Paired T-test). . 53 XXVI. Preferences ............................... 53 vii Abstract This rsearch -focused

77 FR 73678 - Robert M. Brodkin, D.P.M.; Decision and Order

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... Demerol 50 mg/ml (meperidine, a schedule II narcotic); 1200 tablets of diazepam (a schedule IV benzodiazepine); 1500 tablets of hydrocodone/acetaminophen 10/500 mg and 1700 tablets of hydrocodone...); 200 tablets of propoxyphene (a schedule IV narcotic); and four bottles of testosterone cypionate 10 ml...

78 FR 69612 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings-Title...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... Committee, Negotiator Nominations and Schedule of Committee Meetings--Title IV Federal Student Aid Programs... the Federal Student Aid programs authorized under title IV of the Higher Education Act of 1965, as amended (HEA) (title IV Federal Student Aid programs). The committee will include representatives of...

78 FR 57571 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings-Title...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-19

... Committee, Negotiator Nominations and Schedule of Committee Meetings--Title IV Federal Student Aid Programs... rulemaking process, see The Negotiated Rulemaking Process for Title IV Regulations, Frequently Asked... for consideration were cash management of funds provided under the title IV Federal Student Aid...

48 CFR 1532.006-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Activity, if that individual is not below Level IV of the Executive Schedule. If the Head of the Contracting Activity is below Level IV of the Executive Schedule, then Agency responsibilities and...

48 CFR 1532.006-1 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Contracting Activity, if that individual is not below Level IV of the Executive Schedule. If the Head of the Contracting Activity is below Level IV of the Executive Schedule, then Agency responsibilities and...

Switching from oral extended-release methylphenidate to the methylphenidate transdermal system: continued ADHD symptom control and tolerability after abrupt conversion

PubMed Central

Arnold, L. E.; Hodgkins, P.; McKay, M.; Beckett-Thurman, L.; Greenbaum, M.; Bukstein, O.; Patel, A.; Bozzolo, D. R.

2013-01-01

Objective To evaluate symptom control and tolerability after abrupt conversion from oral extended-release methylphenidate (ER-MPH) to methylphenidate transdermal system (MTS) via a dose-transition schedule in children with attention-deficit/hyperactivity disorder (ADHD). Methods In a 4-week, prospective, multisite, open-label study, 171 children (164 intent-to-treat) with diagnosed ADHD aged 6–12 years abruptly switched from a stable dose of oral ER-MPH to MTS in nominal dosages of 10, 15, 20, and 30 mg using a predefined dose-transition schedule. After the first week on the scheduled dose, the dose was titrated to optimal effect. The primary effectiveness outcome was the change from baseline (while taking ER-MPH) to week 4 in ADHD-Rating Scale-IV (ADHD-RS-IV) total scores. Adverse events (AEs) were assessed throughout the study. Results Most subjects (58%) remained on the initial MTS dose defined by the dose-transition schedule; 38% increased and 4% decreased their MTS dose for optimization. MTS dose optimization resulted in significantly better ADHD-RS-IV total (mean ± SD) scores at week 4 than at baseline (9.9±7.47 vs 14.1±7.48; p<0.0001). The most commonly reported AEs included headache, decreased appetite, insomnia, and upper abdominal pain. Four subjects (2.3%) discontinued because of application site reactions and 3 discontinued because of other AEs. Conclusions Abrupt conversion from a stable dose of oral ER-MPH to MTS was accomplished using a predefined dose-transition schedule without loss of symptom control; however, careful titration to optimal dose is recommended. Most AEs were mild to moderate and, with the exception of application site reactions, were similar to AEs typically observed with oral MPH. Limitations of this study included its open-label sequential design without placebo, which could result in spurious attribution of improvement to the study treatment and precluded superiority determinations of MTS over baseline ER-MPH treatment. The apparent superiority of MTS was likely due to more careful titration and clinical monitoring rather than the product itself. NCT NCT00151983 PMID:19916704

Combating pertussis resurgence: One booster vaccination schedule does not fit all.

PubMed

Riolo, Maria A; Rohani, Pejman

2015-02-03

Pertussis has reemerged as a major public health concern in many countries where it was once considered well controlled. Although the mechanisms responsible for continued pertussis circulation and resurgence remain elusive and contentious, many countries have nevertheless recommended booster vaccinations, the timing and number of which vary widely. Here, using a stochastic, age-stratified transmission model, we searched for cost-effective booster vaccination strategies using a genetic algorithm. We did so assuming four hypothesized mechanisms underpinning contemporary pertussis epidemiology: (I) insufficient coverage, (II) frequent primary vaccine failure, (III) waning of vaccine-derived protection, and (IV) vaccine "leakiness." For scenarios I-IV, successful booster strategies were identified and varied considerably by mechanism. Especially notable is the inability of booster schedules to alleviate resurgence when vaccines are leaky. Critically, our findings argue that the ultimate effectiveness of vaccine booster schedules will likely depend on correctly pinpointing the causes of resurgence, with misdiagnosis of the problem epidemiologically ineffective and economically costly.

21 CFR 1301.26 - Exemptions from import or export requirements for personal medical use.

Code of Federal Regulations, 2010 CFR

2010-04-01

... individual who has in his/her possession a controlled substance listed in schedules II, III, IV, or V, which... purposes of this section, a United States resident is a person whose residence (i.e., place of general...

Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery.

PubMed

Shepherd, Deborah M; Jahnke, Heidi; White, William L; Little, Andrew S

2018-02-01

OBJECTIVE Pain control is an important clinical consideration and quality-of-care metric. No studies have examined postoperative pain control following transsphenoidal surgery for pituitary lesions. The study goals were to 1) report postoperative pain scores following transsphenoidal surgery, 2) determine if multimodal opioid-minimizing pain regimens yielded satisfactory postoperative pain control, and 3) determine if intravenous (IV) ibuprofen improved postoperative pain scores and reduced opioid use compared with placebo. METHODS This study was a single-center, randomized, double-blinded, placebo-controlled intervention trial involving adult patients with planned transsphenoidal surgery for pituitary tumors randomized into 2 groups. Group 1 patients were treated with scheduled IV ibuprofen, scheduled oral acetaminophen, and rescue opioids. Group 2 patients were treated with IV placebo, scheduled oral acetaminophen, and rescue opioids. The primary end point was patient pain scores (visual analog scale [VAS], rated 0-10) for 48 hours after surgery. The secondary end point was opioid use as estimated by oral morphine equivalents (OMEs). RESULTS Of 136 patients screened, 62 were enrolled (28 in Group 1, 34 in Group 2). The study was terminated early because the primary and secondary end points were reached. Baseline characteristics between groups were well matched except for age (Group 1, 59.3 ± 14.4 years; Group 2, 49.8 ± 16.2 years; p = 0.02). Mean VAS pain scores were significantly different, with a 43% reduction in Group 1 (1.7 ± 2.2) compared with Group 2 (3.0 ± 2.8; p < 0.0001). Opioid use was significantly different, with a 58% reduction in Group 1 (26.3 ± 28.7 mg OME) compared with Group 2 (62.5 ± 63.8 mg OME; p < 0.0001). CONCLUSIONS Multimodal opioid-minimizing pain-management protocols resulted in acceptable pain control following transsphenoidal surgery. IV ibuprofen resulted in significantly improved pain scores and significantly decreased opioid use compared with placebo. Postoperative multimodal pain management, including a nonsteroidal antiinflammatory medication, should be considered after surgery to improve patient comfort and to limit opioid use. Clinical trial registration no.: NCT02351700 (clinicaltrials.gov) ■ CLASSIFICATION OF EVIDENCE Type of question: therapeutic; study design: randomized, controlled trial; evidence: Class III.

Impact of Postoperative Intravenous Acetaminophen on Opioid Requirements and Pain Scores Following Gynecologic Procedures.

PubMed

Stoudenmire, Laura G; Norman, Christy M; Latif, Erin Z

2016-10-01

This study aims to assess the impact of postoperative intravenous (IV) acetaminophen on opioid requirements and pain scores in patients following gynecologic procedures. A retrospective cohort study of patients undergoing gynecologic procedures was conducted to assess the impact of adding scheduled IV acetaminophen to postoperative analgesic regimens. The control group consisted of patients admitted prior to formulary addition of IV acetaminophen; the study group consisted of patients admitted after formulary addition of IV acetaminophen who received scheduled IV acetaminophen for at least the first 24 hours postoperatively. Opioid requirements 0 to 24 hours postoperatively served as the primary end point. Secondary end points included average pain score, cumulative acetaminophen dose, nonopioid analgesic requirements, and rate of adverse events 0 to 24 hours postoperatively. One hundred and thirty-seven patients who underwent a gynecologic procedure from January 2009 to April 2013 were included in this study. Baseline characteristics were similar between the groups. In the first 24 hours postoperatively, there was no difference in opioid requirements between the groups (21 mg [interquartile range, IQR, 15-39.8 mg] vs 32.6 mg [IQR, 16.75-41 mg], P = 0.150). The average pain score and incidence of adverse events did not differ between the 2 groups. Postoperative administration of IV acetaminophen did not provide a significant opioid-sparing effect in patients undergoing gynecologic procedures. © The Author(s) 2015.

A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, Velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies.

PubMed

Ma, Cynthia; Mandrekar, Sumithra J; Alberts, Steven R; Croghan, Gary A; Jatoi, Aminah; Reid, Joel M; Hanson, Lorelei J; Bruzek, Laura; Tan, Angelina D; Pitot, Henry C; Erlichman, Charles; Wright, John J; Adjei, Alex A

2007-02-01

Bortezomib, a selective inhibitor of the 20S proteasome with activity in a variety of cancers, exhibits sequence-dependent synergistic cytotoxicity with taxanes and platinum agents. Two different treatment schedules of bortezomib in combination with paclitaxel and carboplatin were tested in this phase I study to evaluate the effects of scheduling on toxicities, pharmacodynamics and clinical activity. Patients with advanced malignancies were alternately assigned to receive (schedule A) paclitaxel and carboplatin (IV d1) followed by bortezomib (IV d2, d5, d8) or (schedule B) bortezomib (IV d1, d4, d8) followed by paclitaxel and carboplatin (IV d2) on a 21-day cycle. Fifty-three patients (A 25, B 28) were treated with a median of 3 cycles (range 1-8) for schedule A and 3.5 cycles (range 1-10) for schedule B. Grade 3 or higher treatment related hematologic adverse events in all cycles of treatment included neutropenia (A 52%, B 50%), anemia (A 12%, B 7.1%) and thrombocytopenia (A 16%, B 17.9%). Non-hematologic treatment related adverse events were fairly mild (primarily grades 1 and 2). The maximum tolerated dose and the recommended doses for future phase II trials are bortezomib 1.2 mg/m2, paclitaxel 135 mg/m2 and carboplatin AUC = 6 for schedule A and bortezomib 1.2 mg/m2, paclitaxel 175 mg/m2 and carboplatin AUC = 6 for schedule B. Six (21.4%) partial responses (PR) were seen with schedule B. In contrast, only 1 (4%) PR was achieved with schedule A. Similar proteasome inhibition was achieved at MTD for both schedules. Administration of sequential bortezomib followed by chemotherapy (schedule B) was well tolerated and associated with an encouraging number of objective responses in this small group of patients. Further studies with this administration schedule are warranted.

Cryptococcal meningitis management in Tanzania with strict schedule of serial lumber punctures using intravenous tubing sets: an operational research study.

PubMed

Meda, John; Kalluvya, Samuel; Downs, Jennifer A; Chofle, Awilly A; Seni, Jeremiah; Kidenya, Benson; Fitzgerald, Daniel W; Peck, Robert N

2014-06-01

Cryptococcal meningitis (CM) has a mortality rate of ∼70% among HIV-infected adults in low-income countries. Controlling intracranial pressure (ICP) is essential in CM, but it is difficult in low-income countries because manometers and practical ICP management protocols are lacking. As part of a continuous quality improvement project, our Tanzanian hospital initiated a new protocol for ICP management for CM. All adult inpatients with CM are included in a prospective patient registry. At the time of analysis, this registry included data from 2 years before the initiation of this new ICP management protocol and for a 9-month period after. ICP was measured at baseline and at days 3, 7, and 14 by both manometer and intravenous (IV) tubing set. All patients were given IV fluconazole according to Tanzanian treatment guidelines and were followed until 30 days after admission. Among adult inpatients with CM, 32 of 35 patients (91%) had elevated ICP on admission. Cerebrospinal fluid pressure measurements using the improvised IV tubing set demonstrated excellent agreement (r = 0.96) with manometer measurements. Compared with historical controls, the new ICP management protocol was associated with a significant reduction in 30-day mortality (16/35 [46%] vs. 48/64 [75%] in historical controls; hazard ratio = 2.1 [95% CI: 1.1 to 3.8]; P = 0.018]. Increased ICP is almost universal among HIV-infected adults admitted with CM in Tanzania. Intensive ICP management with a strict schedule of serial lumbar punctures reduced in-hospital mortality compared with historical controls. ICP measurement with IV tubing sets may be a good alternative in resource-limited health facilities where manometers are not available.

Hypocretin/orexin antagonists decrease cocaine self-administration by female rhesus monkeys.

PubMed

Foltin, Richard W; Evans, Suzette M

2018-07-01

The hypocretin/orexin system is involved in regulating arousal, and much recent work demonstrates that decreasing hypocretin receptor-1 (HCRTr1) activity using antagonists decreases appetitive behavior, including stimulant drug self-administration and reinstatement. The present study determined the effects of hypocretin-1 and HCRTr1 antagonists on responding reinforced by intravenous (i.v.) cocaine self-administration (0.0125 - 0.05 mg/kg/infusion) in 5 female rhesus monkeys. Responding was examined using 3 schedules of reinforcement: 1) a Fixed interval 1 min, Fixed ratio 10 Chain schedule [FI 1-min (FR10:S)], 2) a Progressive Ratio (PR) schedule, and 3) a cocaine vs. candy. Choice schedule: the HCRTr1 antagonist SB-334867 (8-24 mg/kg, i.m.) decreased cocaine taking under the Chain schedule and PR schedule in all 5 monkeys and in 4 of the 5 monkeys under the Choice schedule. d- Amphetamine (0.06 - 0.25 mg/kg, i.m.), tested as a control manipulation, decreased cocaine taking in all 5 monkeys under the Chain schedule. The peptide hypocretin-1 (0.072 mg/kg, i.v.) increased cocaine taking in the monkeys with low rates of cocaine taking under the Chain (3/4) and Choice (4/5) schedules. Reinstatement of extinguished cocaine responding following response-independent delivery of a large dose of cocaine (0.3 mg/kg) was attenuated in 3 of the 5 monkeys by the HCRTr1 antagonist SB-334867. These data expand upon work accomplished in predominantly male rodents suggesting that the hypocretin system modulates the response to appetitive stimuli. A better understanding of this system offers promise as a novel approach in medication development for appetitive disorders. Copyright © 2018 Elsevier B.V. All rights reserved.

21 CFR 1308.14 - Schedule IV.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Schedule IV. 1308.14 Section 1308.14 Food and... isomers is possible: (1) Fenfluramine 1670 (e) Stimulants. Unless specifically excepted or unless listed... the following substances having a stimulant effect on the central nervous system, including its salts...

40 CFR 86.004-25 - Maintenance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... either emission-related or non-emission-related and each of these can be classified as either scheduled... component whose sole or primary purpose is to reduce emissions or whose failure will significantly degrade emissions control and whose function is not integral to the design and performance of the engine.) (iv) For...

40 CFR 86.004-25 - Maintenance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... either emission-related or non-emission-related and each of these can be classified as either scheduled... component whose sole or primary purpose is to reduce emissions or whose failure will significantly degrade emissions control and whose function is not integral to the design and performance of the engine.) (iv...

SLURM: Simple Linux Utility for Resource Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jette, M; Dunlap, C; Garlick, J

2002-04-24

Simple Linux Utility for Resource Management (SLURM) is an open source, fault-tolerant, and highly scalable cluster management and job scheduling system for Linux clusters of thousands of nodes. Components include machine status, partition management, job management, and scheduling modules. The design also includes a scalable, general-purpose communication infrastructure. Development will take place in four phases: Phase I results in a solid infrastructure; Phase II produces a functional but limited interactive job initiation capability without use of the interconnect/switch; Phase III provides switch support and documentation; Phase IV provides job status, fault-tolerance, and job queuing and control through Livermore's Distributed Productionmore » Control System (DPCS), a meta-batch and resource management system.« less

21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

Code of Federal Regulations, 2010 CFR

2010-04-01

... between two licensed pharmacists and the transferring pharmacist records the following information: (i... transferred and the name of the pharmacist receiving the prescription information. (iii) Record the date of the transfer and the name of the pharmacist transferring the information. (b) The pharmacist receiving...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

40 CFR 265.1064 - Recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

...). (iii) Type of equipment (e.g., a pump or pipeline valve). (iv) Percent-by-weight total organics in the...)(2), an implementation schedule as specified in § 265.1033(a)(2). (3) Where an owner or operator... concentration achieved by the control device, a performance test plan as specified in § 265.1035(b)(3). (4...

[Effects of granisetron/lidocaine combination on propofol injection-induced pain: a double-blind randomized clinical trial].

PubMed

Ma, Yu-shan; Lin, Xue-mei; Zhou, Jun

2009-05-01

To investigate the alleviation effect of vein pretreatment and granisetron/lidocaine combination on propofol injection-induced pain. Two hundreds patients scheduled for gynaecological laparoscopic operations were randomly divided into four groups: control group (group I), lidocaine group (group II), granisetron group (group III) and granisetron/lidocaine combination group (group IV), with 50 patients in each group. The patients in the above four groups received placebo (saline), lidocaine 20 mg, granisetron 2 mg and granisetron 2 mg plus lidocaine intravenously respectively. The patients were injected with one-forth of scheduled propofol via a dorsal hand vein after one minute of venous occlusion. The pain during the injection of propofol was evaluated. Pain occurred in 84% of patients in the control group, 46% in the lidocaine group, 52% in the granisetron group and 24% in the granisetron/lidocaine combination group. There was a significant reduction in pain incidence in the three experimental groups compared with the control group (P<0.05). The incidence of pain, nausea, vomiting and shivering was less in the granisetron/lidocaine combination group than in the control group (P<0.05). Pretreatment with granisetron/lidocaine may be effective not only in attenuating pains during i.v. injection of propofol, but also in preventing postoperative nausea, vomiting and shivering.

Multivariable Control Law Design for the AFTI/F-16 with a Failed Control Surface Using a Parameter-Adaptive Controller.

DTIC Science & Technology

1987-12-01

Appendix D: Macro Listings D-1 Appendix E: MATRIXx Simulation E-1 Bibiliography Vita iv e List of Figures Figure Page 1-1 Self -Tuning Regulator 6 2-1 AFTI...Command 59 4-25 Yaw Rate Command - Three Pulses 60 4-26 Adaptive Yaw Rate Respose - Three Pulses 61 4-27 Adaptive Pitch Angle Response - Three Pulses 62 4...several types of adaptive controllers (regulators). Three of the simplest controllers are gain scheduling, model reference, and self -tuning

The willingness of patients to pay for intravenous patient-controlled analgesia in Korea.

PubMed

Lim, Hyungsun; Lee, Duck-Hyoung; Lee, Jeongwoo; Han, Young Jin; Choe, Huhn; Son, Ji-Seon

2012-06-01

The use of intravenous patient-controlled analgesia (IV-PCA) has been increasing because it has advantages such as improved pain relief, greater patient satisfaction, and fewer postoperative complications. However, current research has not considered the patients' thoughts about IV-PCA's cost-effectiveness. The purpose of this study was to investigate the willingness to pay (WTP) for IV-PCA and the relationship between patients' characteristics and WTP in Korea. We enrolled 400 adult patients who were scheduled for elective surgery. The patient was requested to indicate a series of predefined amounts of money (Korean won; 30,000/50,000/100,000/150,000/200,000/300,000/500,000). We also recorded patient characteristics, such as age, sex, type of surgery, IV-PCA history, education level, the person responsible for medical expenses, type of insurance, net annual income, and residential area. Three days after surgery, we asked about the degree of satisfaction and the WTP for IV-PCA. For IV-PCA, the median WTP was 100,000 won (25-75%; 50,000-200,000 won: US$1 = W1078.04; July 19, 2011) before surgery. All patients' characteristics were not related to preoperative WTP for IV-PCA, whereas the increase in WTP after surgery showed a tendency correlated to higher IV-PCA satisfaction. The median WTP was 100,000 won. The satisfaction of IV-PCA increased patients' WTP after surgery, but the WTP may be independent of patient characteristics in Korea.

21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

Code of Federal Regulations, 2012 CFR

2012-04-01

...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

Code of Federal Regulations, 2014 CFR

2014-04-01

...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

Code of Federal Regulations, 2013 CFR

2013-04-01

...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

21 CFR 1306.25 - Transfer between pharmacies of prescription information for Schedules III, IV, and V controlled...

Code of Federal Regulations, 2011 CFR

2011-04-01

...: (1) The transfer must be communicated directly between two licensed pharmacists. (2) The transferring pharmacist must do the following: (i) Write the word “VOID” on the face of the invalidated prescription; for... registration number of the pharmacy to which it was transferred and the name of the pharmacist receiving the...

Evaluation of an every-other-day palonosetron schedule to control emesis in multiple-day high-dose chemotherapy.

PubMed

Mirabile, Aurora; Celio, Luigi; Magni, Michele; Bonizzoni, Erminio; Gianni, Alessandro Massimo; Di Nicola, Massimo

2014-12-01

Efficacy of intermittent palonosetron dosing in patients undergoing multiple-day, high-dose chemotherapy (HDC) was investigated. Fifty-eight patients received palonosetron (0.25 mg intravenous [iv.]) every other day plus daily dexamethasone (8 mg iv. twice daily) dosing. The primary end point was complete control (CC; no emesis, no rescue anti-emetics, and no more than mild nausea) in the overall acute-period (until 24 h after chemotherapy completion). Acute-period CC occurred in 81% and 50% of patients receiving palonosetron and ondansetron (historical control cohort), respectively. Palonosetron (odds ratio [OR]: 4.37; p = 0.001) and a longer duration of HDC regimen (OR: 3.47; p = 0.011) independently predicted a better anti-emetic outcome. Palonosetron every other day plus daily dexamethasone is an effective anti-emetic coverage in patients undergoing HDC.

Orion EFT-1 Wet Dress Rehearsal

NASA Image and Video Library

2014-11-05

In the Hangar A&E control room, displays are seen during a dress rehearsal for the launch of the United Launch Alliance Delta IV Heavy rocket for the upcoming Orion Flight Test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Preliminary design of a solar central receiver for a site-specific repowering application (Saguaro Power Plant). Volume IV. Appendixes. Final report, October 1982-September 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, E.R.

1983-09-01

The appendixes for the Saguaro Power Plant includes the following: receiver configuration selection report; cooperating modes and transitions; failure modes analysis; control system analysis; computer codes and simulation models; procurement package scope descriptions; responsibility matrix; solar system flow diagram component purpose list; thermal storage component and system test plans; solar steam generator tube-to-tubesheet weld analysis; pipeline listing; management control schedule; and system list and definitions.

20 CFR 638.505 - Scheduling of training.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Scheduling of training. 638.505 Section 638.505 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.505 Scheduling of training...

76 FR 45710 - Pay in Nonforeign Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... for the purpose of computing nonforeign area COLAs and post differentials, a retained rate established... limited by the normally applicable Executive Schedule level IV (EX-IV) cap on special rates ($155,500 in... special rate in excess of the EX-IV cap at the end of the transition period must be converted to a...

Intrathecal morphine for postoperative pain control following robot-assisted prostatectomy: a prospective randomized trial.

PubMed

Bae, Junyeol; Kim, Hyun-Chang; Hong, Deok Man

2017-08-01

Robot-assisted laparoscopic prostatectomy (RALP) is minimally invasive surgery, but also causes moderate to severe pain during the immediate postoperative period. We evaluated the efficacy and safety of intrathecal morphine (ITM) for postoperative pain control in patients undergoing RALP. Thirty patients scheduled for RALP were randomly assigned into one of two groups. In the ITM group (n = 15), postoperative pain was managed using 300 µg intrathecal morphine with intravenous patient-controlled analgesia (IV-PCA). In the IV-PCA group (n = 15), only intravenous patient-controlled analgesia was used. The numerical pain score (NPS; 0 = no pain, 100 = worst pain imaginable), postoperative IV-PCA requirements and opioid-related complications including nausea, vomiting, dizziness, headache and pruritus were compared between the two groups. The NPSs on coughing were 20 (IQR 10-50) in the ITM group and 60 (IQR 40-80) in the IV-PCA group at postoperative 24 h (p = 0.001). The NPSs were significantly lower in the ITM group up to postoperative 24 h. The ITM group showed less morphine consumption at postoperative 24 h in the ITM group than in the IV-PCA group [5 (IQR 3-15) mg vs 17 (IQR 11-24) mg, p = 0.001]. Complications associated with morphine were comparable between the two groups and respiratory depression was not reported in either group. Intrathecal morphine provided more satisfactory analgesia without serious complications during the early postoperative period in patients undergoing RALP.

12 CFR 327.10 - Assessment rate schedules.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) The risk factors and other factors taken into account pursuant to 12 U.S.C. 1817(b)(1); and (v) Any... prescribed in the following schedule: Initial Base Assessment Rate Schedule Risk category I * Minimum Maximum II III IV Annual rates (in basis points) 12 16 22 32 45 * All amounts for all risk categories are in...

12 CFR 327.10 - Assessment rate schedules.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) The risk factors and other factors taken into account pursuant to 12 U.S.C. 1817(b)(1); and (v) Any... prescribed in the following schedule: Initial Base Assessment Rate Schedule Risk category I * Minimum Maximum II III IV Annual rates (in basis points) 12 16 22 32 45 * All amounts for all risk categories are in...

1L Mark-IV Target Design Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koehler, Paul E.

This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

Tramadol wound infiltration is not different from intravenous tramadol in children: a randomized controlled trial.

PubMed

Giraldes, Ana Laura Albertoni; Sousa, Angela Maria; Slullitel, Alexandre; Guimarães, Gabriel Magalhães Nunes; Santos, Melina Geneviève Mary Egan; Pinto, Renata Evangelista; Ashmawi, Hazem Adel; Sakata, Rioko Kimiko

2016-02-01

The purpose of this trial was to assess if tramadol wound infiltration is superior to intravenous (IV) tramadol after minor surgical procedures in children because tramadol seems to have local anesthetic-like effect. Randomized double-blind controlled trial. Postanesthesia care unit. Forty children, American Society of Anesthesiologists physical status I or II, scheduled to elective inguinal hernia repair. Children were randomly distributed in 1 of 2 groups: IV tramadol (group 1) or subcutaneous infiltration with tramadol (group 2). At the end of the surgery, group 1 received 2 mg/kg tramadol (3 mL) by IV route and 3-mL saline into the surgical wound; group 2 received 2 mg/kg tramadol (3 mL) into the surgical wound and 3-mL saline by IV route. In the postanesthesia care unit, patients were evaluated for pain intensity, nausea and vomiting, time to first rescue medication, and total rescue morphine and dipyrone consumption. Pain scores measured during the postanesthesia recovery time were similar between groups. Time to first rescue medication was shorter, but not statistically significant in the IV group. The total dose of rescue morphine and dipyrone was also similar between groups. We concluded that tramadol was effective in reducing postoperative pain in children, and there was no difference in pain intensity, nausea and vomiting, or somnolence regarding IV route or wound infiltration. Copyright © 2016 Elsevier Inc. All rights reserved.

Influence of pre- or intraoperational use of tramadol (preemptive or preventive analgesia) on tramadol requirement in the early postoperative period.

PubMed

Wordliczek, Jerzy; Banach, Marcin; Garlicki, Jarosław; Jakowicka-Wordliczek, Joanna; Dobrogowski, Jan

2002-01-01

The aim of this study was to assess the influence of iv tramadol on opioid requirement in the early postoperative period. The subjects were 90 patients scheduled for colon surgery (hemicolectomy) who received general anesthesia using the (N2O/O2) isoflurane technique. Thirty patients (group I) were administered 100 mg of tramadol iv before induction of general anesthesia (preemptive analgesia). Group II (30 patients) was administered 100 mg of tramadol iv immediately after peritoneal closure (preventive analgesia) and control group (30 patients) received 100 mg of tramadol iv immediately after operation. Following the operation, all patients were administered tramadol in the PCA-iv mode in order to treat postoperative pain. In the postoperative period, the following parameters were measured: pain intensity (using VAS), total consumption of tramadol, time until the first PCA activation, and frequency of side effects (drowsiness, nausea, vomiting). In patients of groups I and II who had received preemptive or preventive analgesia, a significantly lower total consumption of tramadol, as compared with control group, was observed in the early postoperative period. However, the time until the first PCA activation was significantly shorter in group I as compared to the other two groups. No significant differences between the groups were found regarding pain intensity and frequency of side effects.

Middle School A/B Block and Traditional Scheduling: An Analysis of Math and Reading Performance by Race

ERIC Educational Resources Information Center

Gill, Willie Wallicia Allen

2011-01-01

The purpose of this quantitative study was to examine whether a difference existed in the percentage performance of students earning a pass/advanced score on the Standards of Learning (SOL) Test in math and reading in Virginia's Region IV for schools using an A/B block schedule and those using a traditional schedule. The research also examined if…

Decompression from He-N2-O2 (TRIMIX) Bounce Dives Is Not More Efficient Than From He-O2 (HELIOX) Bounce Dives

DTIC Science & Technology

2015-05-28

Diver Characteristics Appendix E Diving Schedule Appendix F Medical Incidents Appendix G UBA Gas Compositions iv ACKNOWLEDGEMENTS The...experimental dives (median = 3). The schedule of each diver’s participation in experimental dives is given in Appendix E . Divers were required to avoid any...divers’ participation on each test schedule is given in Appendix E . The numbers of completed man-dives on the two schedules are not multiples of the

Real-time Data Streams from ``e-RemoteCtrl'' to Central VLBI Network Status Monitoring Services Like IVS Live

NASA Astrophysics Data System (ADS)

Neidhardt, Alexander; Collioud, Arnaud

2014-12-01

A central VLBI network status monitoring can be realized by using online status information about current VLBI sessions, real-time, and status data directly from each radio telescope. Such monitoring helps to organize sessions or to get immediate feedback from the active telescopes. Therefore the remote control software for VLBI radio telescopes ``e-RemoteCtrl'' (http://www.econtrol-software.de), which enables remote access as extension to the NASA Field System, realizes real-time data streams to dedicated data centers. The software has direct access to the status information about the current observation (e.g., schedule, scan, source) and the telescope (e.g., current state, temperature, pressure) in real-time. This information are directly sent to ``IVS Live''. ``IVS Live'' (http://ivslive.obs.u-bordeaux1.fr/) is a Web tool that can be used to follow the observing sessions, organized by the International VLBI Service for Geodesy and Astrometry (IVS), navigate through past or upcoming sessions, or search and display specific information about sessions, sources (like VLBI images), and stations, by using an Internet browser.

Coordinating, Scheduling, Processing and Analyzing IYA09

NASA Technical Reports Server (NTRS)

Gipson, John; Behrend, Dirk; Gordon, David; Himwich, Ed; MacMillan, Dan; Titus, Mike; Corey, Brian

2010-01-01

The IVS scheduled a special astrometric VLBI session for the International Year of Astronomy 2009 (IYA09) commemorating 400 years of optical astronomy and 40 years of VLBI. The IYA09 session is the most ambitious geodetic session to date in terms of network size, number of sources, and number of observations. We describe the process of designing, coordinating, scheduling, pre-session station checkout, correlating, and analyzing this session.

Value of Intensity-Modulated Radiotherapy in Stage IV Head-and-Neck Squamous Cell Carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dirix, Piet, E-mail: piet.dirix@uzleuven.b; Nuyts, Sandra

2010-12-01

Purpose: To review outcome and toxicity of Stage IVa and IVb head-and-neck squamous cell carcinoma patients treated with concomitant chemotherapy and intensity-modulated radiotherapy (IMRT) according to a hybrid fractionation schedule. Methods and Materials: Between 2006 and 2008, 42 patients with Stage IV head-and-neck squamous cell carcinoma were irradiated according to a hybrid fractionation schedule consisting of 20 fractions of 2 Gy (once daily), followed by 20 fractions of 1.6 Gy (twice daily), to a total dose of 72 Gy. Chemotherapy (cisplatinum, 100mg/m{sup 2}) was administered at the start of Weeks 1 and 4. Treatment outcome and toxicity were retrospectively comparedmore » with a previous patient group (n = 55), treated according to the same schedule, but without intensity modulation. Results: Locoregional control (LRC) and overall survival were 81% and 56% after 2 years, respectively. In comparison with the previous cohort, no significant differences were observed regarding either LRC (66%, p = 0.38) or overall survival (73%, p = 0.29). No Grade 4 or 5 toxicity was reported in the IMRT group, either acute or chronic. The use of IMRT significantly reduced the incidence of late Grade 2 or 3 xerostomia (52.9% vs. 90.2%, p < 0.001). No difference was observed regarding late Grade 2 or 3 dysphagia (p = 0.66). Conclusions: Intensity-modulated chemoradiotherapy does not compromise LRC and significantly reduces late toxicity, especially regarding xerostomia.« less

Ondansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy : A randomized placebo-controlled study.

PubMed

Erhan, Yamac; Erhan, Elvan; Aydede, Hasan; Yumus, Okan; Yentur, Alp

2008-06-01

Laparoscopic cholecystectomies are associated with an appreciably high rate of postoperative nausea and vomiting (PONV). This study was designed to compare the effectiveness of ondansetron, granisetron, and dexamethasone for the prevention of PONV in patients after laparoscopic cholecystectomy. A total of 80 American Society of Anesthesiologists (ASA) physical class I-II patients scheduled for laparoscopic cholecystectomy were included in this randomized, double blind, placebo-controlled study. All patients received a similar standardized anesthesia and operative treatment. Patients were randomly divided into four groups (n = 20 each). Group 1, consisting of control patients, received 0.9% NaCl; group 2 patients received ondansetron 4 mg i.v.; group 3 patients received granisetron 3 mg i.v.; and group 4 patients received dexamethasone 8 mg i.v., all before the induction of anesthesia. Both nausea and vomiting were assessed during the first 24 h after the procedure. The total incidence of PONV was 75% with placebo, 35% with ondansetron, 30% with granisetron, and 25% with dexamethasone. The incidence of PONV was significantly less frequent in groups receiving antiemetics (p < 0.05). The differences between dexamethasone, granisetron, and ondansetron were not significant. Prophylactic dexamethasone 8 mg i.v. significantly reduced the incidence of PONV in patients undergoing laparoscopic cholecystectomy. Dexamethasone 8 mg was as effective as ondansetron 4 mg and granisetron 3 mg, and it was more effective than placebo.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, A.P.; Camporesi, E.M.; Sell, T.L.

The effect of intravenous (IV) nitroglycerin (NTG) on perioperative myocardial ischemia as detected by single pass radionuclide angiocardiography was studied in 20 patients scheduled for elective coronary artery bypass grafting (CABG). Ten patients, selected at random, received IV NTG 1 microgram.kg-1.min-1 (NTG group) and 10 others, IV saline (control group). Anesthetic induction consisted of midazolam 0.2 mg.kg-1, vecuronium 0.1 mg.kg-1, and 50% N{sub 2}O in O{sub 2}. ECG leads I, II, and V5 were monitored for ST segment changes. Single pass radionuclide angiocardiography (RNA) was performed at 5 times: prior to induction, prior to tracheal intubation, and at 1, 3.5,more » and 6 min following intubation. The presence of new regional wall motion abnormalities (RWMA) was determined from each RNA study as compared with the preinduction measurement. Apart from one patient in the control group who developed a new v wave after intubation, there was no evidence of ischemia by pulmonary capillary wedge pressure. No ECG evidence of ischemia was detected in any patient. Despite this, new regional wall motion abnormalities were observed in 3 patients in the control group and 1 patient in the NTG group. Blood pressure and heart rate responses of patients with new RWMA were not significantly different from other patients. The low incidence of ischemia in this population precludes a definitive statement regarding the efficacy of IV NTG, but the lower incidence of RWMA in the NTG group suggests a protective effect.« less

Effect of preincision versus postincision infiltration with bupivacaine on postoperative pain.

PubMed

Victory, R A; Gajraj, N M; Van Elstraete, A; Pace, N A; Johnson, E R; White, P F

1995-05-01

To compare the efficacy of preincision wound infiltration with bupivacaine to wound infiltration at the end of the operation. A prospective, randomized, double-blind study. University medical center. 56 ASA status I and II women scheduled for abdominal hysterectomy were randomly assigned to one of three treatment groups. Group 1 (control) received no local anesthetic infiltration. Group 2 received subcutaneous infiltration with 40 ml of bupivacaine 0.5% (pH 6.9) 15 minutes prior to incision. Group 3 received wound infiltration with a similar solution at the end of surgery. Anesthesia was induced with thiopental 3.0 mg/kg i.v., droperidol 50 micrograms/kg i.v., and sufentanil 0.5 microgram/kg i.v. and maintained with nitrous oxide 67% in oxygen and sufentanil 0.1 microgram/kg IV boluses as required. Postoperative pain was treated with morphine via a patient-controlled analgesia delivery system for 24 hours, followed by oral hydrocodone for 3 days. The opioid consumption was recorded for 4 days postoperatively. Pain scores were measured at 4 to 8-hour intervals using 100 mm visual analog scales. There was no difference in either the opioid analgesic requirements or the pain scores between the three study groups. Wound infiltration, either preincision or postincision, had no clinically significant effect on the pain scores or analgesic requirements following abdominal hysterectomy.

Oral cryotherapy reduces mucositis and opioid use after myeloablative therapy--a randomized controlled trial.

PubMed

Svanberg, Anncarin; Birgegård, Gunnar; Ohrn, Kerstin

2007-10-01

Mucositis is a major complication in myeloablative therapy, which often necessitates advanced pharmacological pain treatment, including i.v. opioids. Attempts to prevent oral mucositis have included oral cryotherapy, which has been shown to reduce mucositis, but there is a lack of knowledge concerning the effect of oral cryotherapy on opioid use by reducing the mucositis for patients treated with myeloablative therapy before bone marrow transplantation (BMT). The aim of the present study was to evaluate if oral cryotherapy could delay or alleviate the development of mucositis and thereby reduce the number of days with i.v. opioids among patients who receive myeloablative therapy before BMT. Eighty patients 18 years and older, scheduled for BMT, were included consecutively and randomised to oral cryotherapy or standard oral care. A stratified randomisation was used with regard to type of transplantation. Intensity of pain, severity of mucositis and use of opioids were recorded using pain visual analogue scale (VAS) scores, mucositis index scores and medical and nursing charts. This study showed that patients receiving oral cryotherapy had less pronounced mucositis and significantly fewer days with i.v. opioids than the control group. In the autologous setting, cryotherapy patients also needed significantly lower total dose of opioids. Oral cryotherapy is an effective and well-tolerated therapy to alleviate mucositis and consequently reduce the number of days with i.v. opioids among patients treated with myeloablative therapy before BMT.

5 CFR 531.606 - Maximum limits on locality rates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... than or equal to the maximum payable scheduled annual rate of pay for GS-15; or (ii) The rate for level... Section 531.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY... of basic pay payable for level IV of the Executive Schedule. (b)(1) A locality rate for an employee...

78 FR 35179 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings-Title...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... title IV Federal Student Aid programs; regulations designed to prevent fraud; State authorization for... Against Women Reauthorization Act of 2013 to the campus safety and security reporting requirements in the... regulations designed to prevent fraud and otherwise ensure proper use of title IV Federal Student Aid program...

NARDAC Civilian DP Training: A Need for Management Attention.

DTIC Science & Technology

1982-12-01

POSITION DESCRIPTIONS ------------------------ 28 D. TRAINING ------------------------------------- 31 IV. NARDAC ORGANIZATIONAL DIAGNOSIS ------------------ 32...the production schedule. 31 IV. NARDAC ORGANIZATIONAL DIAGNOSIS The upper level manager of a highly sophisticated, production oriented ADP facility...14 September 1982. 22. Preziosi, R.C., " Organizational Diagnosis Questicnnaire", The 1990 Annual Handbook for Group Facilitators, p. 112, University

A qualitative study of the cultural appropriateness of the Diagnostic Interview Schedule for Children (DISC-IV) in South Africa

PubMed Central

Skinner, Donald; Serekoane, Motsaathebe; Ross, Michael W.

2012-01-01

Background The Diagnostic Interview Schedule for Children (DISC-IV) has been designed for use by trained laypersons. It therefore shows great promise for use in developing countries such as South Africa, where there is a lack of clinically trained and skilled professionals at the primary care level. Against this background, the aim of the current study was to investigate the sociocultural appropriateness of the DISC-IV for use with Sesotho families in South Africa. Methods Qualitative methodology of expert review and contextualized content analyses were used. Ten Sesotho-speaking clinicians were recruited through a snowball sampling technique to the review the DISC through expert review reports. Results Several themes emerged, including the structure of the DISC-IV, its computerized nature, Americanisms, problems in interpretation due to the adversity children live under, language problems, the effect of rural settings and education level, and cultural norms regarding psychiatric symptoms, gender, the experience of time, the expression of emotion, and family structure. Conclusion Recommendations for the sociocultural adaptation and translation of the DISC into Sesotho are made. PMID:20526764

Improving Quality of Seal Leak Test Product using Six Sigma

NASA Astrophysics Data System (ADS)

Luthfi Malik, Abdullah; Akbar, Muhammad; Irianto, Dradjad

2016-02-01

Seal leak test part is a polyurethane material-based product. Based on past data, defect level of this product was 8%, higher than the target of 5%. Quality improvement effort was done using six sigma method that included phases of define, measure, analyse, improve, and control. In the design phase, a Delphi method was used to identify factors that were critical to quality. In the measure phase, stability and process capability was measured. Fault tree analysis (FTA) and failure mode and effect analysis (FMEA) were used in the next phase to analize the root cause and to determine the priority issues. Improve phase was done by compiling, selecting, and designing alternative repair. Some improvement efforts were identified, i.e. (i) making a checklist for maintenance schedules, (ii) making written reminder form, (iii) modifying the SOP more detail, and (iv) performing a major service to the vacuum machine. To ensure the continuity of improvement efforts, some control activities were executed, i.e. (i) controlling, monitoring, documenting, and setting target frequently, (ii) implementing reward and punishment system, (iii) adding cleaning tool, and (iv) building six sigma organizational structure.

Surgical scheduling categorization system (SSCS): A novel classification system to improve coordination and scheduling of operative cases in a tertiary pediatric medical system.

PubMed

Gantwerker, Eric A; Bannos, Cassandra; Cunningham, Michael J; Rahbar, Reza

2017-01-01

To describe a surgical categorization system to create a universal nomenclature, delineating patient complexity as a first step toward developing a true risk stratification system. Retrospective database review of all otolaryngology surgical procedures performed in a tertiary pediatric hospital system over one academic year (July 2012-June 2013). All otolaryngology surgical procedures were reviewed, encompassing 8478 procedures on 5711 patients. The attending otolaryngologist assigned surgical scheduling category (SSCS) at the time of case booking based on an institution specific guidelines. The guidelines are as follow: Category I was assigned to American Society of Anesthesiologists physical status classification (ASA) I/II patients, designating them appropriate for institution's suburban ambulatory surgery centers; Category II was ASA I/II patients with social or transportation issues; Category III was ASA I/II patients who required case coordination with other medical or surgical departments; Category IV was reserved for patients of any ASA class whom the surgeon designated to be of a higher complexity. 8478 total procedures analyzed with 7198 having complete records. 48% were Category I, 13.6% were Category II, 1.9% were Category III and 36.5% were Category IV. The ASA were 34.7% ASA I, 50% ASA II, 13.39% ASA III, and 1.9% ASA IV. Although the largest proportion of patients were ASA II (50%), 39.6% of all ASA II were Category IV. Category IV was split into 54.2% ASA II and 34% ASA III and shows that peri-operative surgical concerns were not encompassed by the ASA system. This surgical categorization system streamlines surgical scheduling in a tertiary pediatric hospital system, particularly with respect to the designation of cases as ambulatory surgery center or main operating room appropriate. The case mix complexity is also readily apparent, enhancing recognition of the coordination and attention required for the perioperative management of high complexity patients. The SSCS helps convey concerns not addressed by ASA physical status alone. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Intravenous dexamethasone versus ketamine gargle versus intravenous dexamethasone combined with ketamine gargle for evaluation of post-operative sore throat and hoarseness: A randomized, placebo-controlled, double blind clinical trial

PubMed Central

Safavi, Mohammadreza; Honarmand, Azim; Fariborzifar, Arghavan; Attari, Mohammadali

2014-01-01

Background: Sore throat and hoarseness are the most frequent subjective complaints after tracheal intubation for general anesthesia. We conducted a prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intravenous (IV) dexamethasone plus ketamine gargle for reducing the incidence and severity of post-operative sore throat (POST) and hoarseness. Materials and Methods: 140 patients (aged 16-65 year) scheduled for elective surgery were enrolled. Patients were randomly allocated into four groups of 35 subjects each: Group K, gargled 40 mg ketamine in 30 ml saline; Group D, were infused 0.2 mg/kg IV dexamethasone; Group KD, gargled 40 mg ketamine in 30 ml saline plus 0.2 mg/kg IV dexamethasone; Group P (placebo) that received saline (gargle and IV). POST was graded at 0, 2, 4, 8, 16 and 24 h after operation on a four-point scale (0-3). Results: The incidence and severity of POST were significantly lower in Group KD, compared with the other groups at all times after tracheal extubation for up to 24 h (P < 0.05). Also the incidence and severity of hoarseness were significantly lower in each Groups of KD and K and D compared with group placebo (P < 0.05). Conclusion: The prophylactic use of 0.2 mg/kg of IV dexamethasone plus ketamine gargle significantly reduced the incidence and severity of POST compared with using each of these drugs alone or using placebo. PMID:25371869

Sleep Problems, Comorbid Mental Disorders, and Role Functioning in the National Comorbidity Survey Replication (NCS-R)

PubMed Central

Roth, Thomas; Jaeger, Savina; Jin, Robert; Kalsekar, Anupama; Stang, Paul E.; Kessler, Ronald C.

2007-01-01

Background Little is known about the population prevalence of sleep problems or whether the associations of sleep problems with role impairment are due to comorbid mental disorders. Methods The associations of four 12-month sleep problems (difficulty initiating or maintaining sleep, early morning awakening, nonrestorative sleep) with role impairment were analyzed in the National Comorbidity Survey Replication controlling 12-month DSM-IV anxiety, mood, impulse-control, and substance disorders. The WHO Composite International Diagnostic Interview was used to assess sleep problems and DSM-IV disorders. The WHO Disability Schedule-II (WHO-DAS) was used to assess role impairment. Results Prevalence estimates of the separate sleep problems were in the range 16.4-25.0%, with 36.3% reporting at least one of the four. Mean 12-month duration was 24.4 weeks. All four problems were significantly comorbid with all the 12-month DMS-IV disorders assessed in the survey (median OR: 3.4; 25th-75th percentile: 2.8-3.9) and significantly related to role impairment. Relationships with role impairment generally remained significant after controlling comorbid mental disorders. Nonrestorative sleep was more strongly and consistently related to role impairment than were the other sleep problems. Conclusions The four sleep problems considered here are of public health significance because of their high prevalence and significant associations with role impairment. PMID:16952333

Which Route of Tranexamic Acid Administration is More Effective to Reduce Blood Loss Following Total Knee Arthroplasty?

PubMed

Keyhani, Sohrab; Esmailiejah, Ali Akbar; Abbasian, Mohammad Reza; Safdari, Farshad

2016-01-01

The most appropriate route of tranexamic acid administration is controversial. In the current study, we compared the efficacy of intravenous (IV) and topical intra-articular tranexamic acid in reducing blood loss and transfusion rate in patients who underwent primary total knee arthroplasty. One hundred twenty 120 patients were scheduled to undergo primary total knee arthroplasty. Patients were randomly allocated to three equal groups: IV tranexamic acid (500 mg), topical tranexamic acid (3 g in 100 mL normal saline) and the control. In the topical group, half of the volume was used to irrigate the joint and the other half was injected intra-articularly. The volume of blood loss, hemoglobin (Hb) level at 24 hours postoperative, and rate of transfusion was compared between groups. The blood loss and Hb level were significantly greater and lower in the control group, respectively (P=0.031). Also, the rate of transfusion was significantly greater in the control group (P=0.013). However, IV and topical groups did not differ significantly in terms of measured variables. No patient experienced a thromboembolic event in our study. Tranexamic acid is a useful antifibrinolytic drug to reduce postoperative blood loss, Hb drop, and rate of blood transfusion in patients undergoing total knee arthroplasty. The route of tranexamic acid administration did not affect the efficacy and safety.

Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. IV. Comparison of the safety and efficacy of two dosages of a high-molecular-weight allergoid.

PubMed

Bousquet, J; Hejjaoui, A; Soussana, M; Michel, F B

1990-02-01

Specific immunotherapy is still widely used in grass-pollen allergy, but its side effects may limit its use. We tested the safety and efficacy of a formalinized high-molecular-weight allergoid prepared from a mixed grass-pollen extract with two injection schedules in a double-blind, placebo-controlled study. Eighteen patients received placebo, 19 received the low-dose schedule (maximal dose: 2000 PNU) and 20 received the high-dose schedule (maximal dose: 10,000 PNU). Only one patient presented a systemic reaction of moderate severity for a dose of 1200 PNU. Before the onset of the pollen season, patients had a nasal challenge with orchard grass-pollen grains, a skin test titration, and the titration of serum-specific IgG. Both groups of patients presented a significant reduction in nasal and skin sensitivities and a significant increase in IgG compared to placebo. Symptoms and medications for rhinitis and asthma were studied during the season, and both groups receiving allergoids had a significant reduction of symptom-medication scores for nasal and bronchial symptoms. There was a highly significant correlation between nasal symptom-medication scores during the season and the results of nasal challenges. High-molecular-weight allergoids are safe and effective.

Assessing Internalizing, Externalizing, and Attention Problems in Young Children: Validation of the MacArthur HBQ

ERIC Educational Resources Information Center

Lemery-Chalfant, Kathryn; Schreiber, Jane E.; Schmidt, Nicole L.; Van Hulle, Carol A.; Essex, Marilyn J.; Goldsmith, H. H.

2007-01-01

Objective: To test the validity of the MacArthur Health and Behavior Questionnaire (HBQ) using receiver operating characteristic (ROC) analysis to determine optimal thresholds for the HBQ in predicting Diagnostic Interview Schedule for Children Version-IV (DISC-IV)diagnoses. The roles of child sex, level of impairment, and physical health in…

The Brief Child and Family Phone Interview (BCFPI): 2. Usefulness in Screening for Child and Adolescent Psychopathology

ERIC Educational Resources Information Center

Boyle, Michael H.; Cunningham, Charles E.; Georgiades, Katholiki; Cullen, John; Racine, Yvonne; Pettingill, Peter

2009-01-01

Background: This study examines the use of the Brief Child and Family Phone Interview (BCFPI) to screen for childhood psychiatric disorder based on Diagnostic Interview Schedule for Children Version IV (DISC-IV) classifications of attention-deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD),…

ULA Delta IV Heavy Common Booster Cores for the Parker Solar Pro

NASA Image and Video Library

2017-07-27

The United Launch Alliance Delta IV Heavy common booster core arrives aboard the company's Mariner ship at Port Canaveral in Florida. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Common Booster Cores for the Parker Solar Pro

NASA Image and Video Library

2017-08-01

A United Launch Alliance Delta IV Heavy common booster core is offloaded from the company's Mariner ship at Port Canaveral in Florida. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

Influence of experimental history on nicotine self-administration in squirrel monkeys.

PubMed

Desai, Rajeev I; Sullivan, Katherine A; Kohut, Stephen J; Bergman, Jack

2016-06-01

Methods for establishing robust long-term self-administration of intravenous (i.v.) nicotine, the primary psychoactive agent in tobacco, are not well-established in laboratory animals. Here, we examine the use of a fading procedure to establish robust and consistent i.v. nicotine self-administration under second-order schedule conditions in squirrel monkeys. First, self-administration behavior was developed in two groups of male squirrel monkeys using a second-order fixed-interval 5-min schedule with fixed-ratio 5 units (FI 5-min (FR5: S)). Comparable performances were maintained by i.v. cocaine (0.032 mg/kg/injection (inj); group A, n = 3) and the combination of food delivery (20-30 % condensed milk) and 0.01 mg/kg/inj i.v. nicotine (group B, n = 3). Subsequently, the concentration of condensed milk was gradually reduced to zero in the second group and self-administration behavior was maintained by i.v. nicotine alone. Next, self-administration of a range of doses of i.v. nicotine (0.001-0.032 mg/kg/inj) and, in additional experiments, the minor tobacco alkaloid anatabine (0.01-0.18 mg/kg/inj) was studied in both groups. Results show that nicotine and anatabine had reinforcing effects in both groups. However, optimal doses of nicotine and anatabine maintained significantly higher rates of i.v. self-administration behavior in subjects trained with the fading procedure than in subjects provided with a history of cocaine-maintained responding. These results illustrate conditions under which robust i.v. nicotine self-administration can be established in squirrel monkeys and the influence of prior experimental history in the expression of reinforcing effects of nicotine and anatabine.

KSC-2013-2848

NASA Image and Video Library

2013-06-07

CAPE CANAVERAL, Fla. -- Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, technicians prepare the launch abort motor for connection to the attitude control motor. Both are segments of Orion’s Launch Abort System, which is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Dimitri Gerondidakis

KSC-2013-2847

NASA Image and Video Library

2013-06-07

CAPE CANAVERAL, Fla. -- Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, the launch abort motor has been prepared for connection to the attitude control motor. Both are segments of Orion’s Launch Abort System, which is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Dimitri Gerondidakis

KSC-2013-2844

NASA Image and Video Library

2013-06-07

CAPE CANAVERAL, Fla. -- Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, a technician prepares the launch abort motor for connection to the attitude control motor. Both are segments of Orion’s Launch Abort System, which is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Dimitri Gerondidakis

KSC-2013-2845

NASA Image and Video Library

2013-06-07

CAPE CANAVERAL, Fla. -- Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, a technician prepares the launch abort motor for connection to the attitude control motor. Both are segments of Orion’s Launch Abort System, which is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Dimitri Gerondidakis

KSC-2013-2846

NASA Image and Video Library

2013-06-07

CAPE CANAVERAL, Fla. -- Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, a technician prepares the launch abort motor for connection to the attitude control motor. Both are segments of Orion’s Launch Abort System, which is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Dimitri Gerondidakis

ULA Delta IV Heavy Second Stage & Port Common Booster Core for t

NASA Image and Video Library

2017-08-28

A United Launch Alliance Delta IV Heavy second stage, packaged in its shipping container, arrives at the Horizontal Integration Facility at Cape Canaveral Air Force Station for preflight processing. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Second Stage & Port Common Booster Core for t

NASA Image and Video Library

2017-08-28

A United Launch Alliance Delta IV Heavy second stage, packaged in its shipping container, is offloaded from the company's Mariner ship at Port Canaveral in Florida. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Common Booster Cores for the Parker Solar Pro

NASA Image and Video Library

2017-07-28

A United Launch Alliance Delta IV Heavy common booster core arrives by truck at Cape Canaveral Air Force Station's Launch Complex 37 Horizontal Processing Facility. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Common Booster Cores for the Parker Solar Pro

NASA Image and Video Library

2017-07-27

The United Launch Alliance Delta IV Heavy common booster core arrives aboard the company's Mariner ship and prepared for offload at Port Canaveral in Florida. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Common Booster Cores for the Parker Solar Pro

NASA Image and Video Library

2017-07-28

A United Launch Alliance Delta IV Heavy common booster core is transported by truck inside Cape Canaveral Air Force Station's Launch Complex 37 Horizontal Processing Facility. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Second Stage & Port Common Booster Core for t

NASA Image and Video Library

2017-08-30

A United Launch Alliance Delta IV Heavy common booster core arrives at the Horizontal Integration Facility at Cape Canaveral Air Force Station for preflight processing. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

The alcohol use disorder and associated disabilities interview schedule-IV (AUDADIS-IV): reliability of new psychiatric diagnostic modules and risk factors in a general population sample.

PubMed

Ruan, W June; Goldstein, Risë B; Chou, S Patricia; Smith, Sharon M; Saha, Tulshi D; Pickering, Roger P; Dawson, Deborah A; Huang, Boji; Stinson, Frederick S; Grant, Bridget F

2008-01-01

This study presents test-retest reliability statistics and information on internal consistency for new diagnostic modules and risk factors for alcohol, drug, and psychiatric disorders from the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV). Test-retest statistics were derived from a random sample of 1899 adults selected from 34,653 respondents who participated in the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Internal consistency of continuous scales was assessed using the entire Wave 2 NESARC. Both test and retest interviews were conducted face-to-face. Test-retest and internal consistency results for diagnoses and symptom scales associated with posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and borderline, narcissistic, and schizotypal personality disorders were predominantly good (kappa>0.63; ICC>0.69; alpha>0.75) and reliability for risk factor measures fell within the good to excellent range (intraclass correlations=0.50-0.94; alpha=0.64-0.90). The high degree of reliability found in this study suggests that new AUDADIS-IV diagnostic measures can be useful tools in research settings. The availability of highly reliable measures of risk factors for alcohol, drug, and psychiatric disorders will contribute to the validity of conclusions drawn from future research in the domains of substance use disorder and psychiatric epidemiology.

A Clinical Comparison Study of Attention Deficit/Hyperactivity Disorder (DSM-IV) and Hyperkinetic Disorder (ICD-10) in Indian children and Adolescents

ERIC Educational Resources Information Center

Sitholey, Prabhat; Agarwal, Vivek; Bharti, Vikram

2012-01-01

Aims: To compare the usefulness of DSM IV and ICD-10 DCR criteria in clinic children presenting with the symptoms of inattention and hyperactivity-impulsivity. Methods: 62 children (54 boys and 8 girls) participated in the study. Children were assessed on Kiddie schedule for affective disorders and schizophrenia--present and lifetime version and…

21 CFR 1308.14 - Schedule IV.

Code of Federal Regulations, 2012 CFR

2012-04-01

... which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers and salts of isomers: (1) Cathine ((+)-norpseudoephedrine) 1230 (2...

21 CFR 1308.14 - Schedule IV.

Code of Federal Regulations, 2013 CFR

2013-04-01

... which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers and salts of isomers: (1) Cathine ((+)-norpseudoephedrine) 1230 (2...

21 CFR 1308.14 - Schedule IV.

Code of Federal Regulations, 2014 CFR

2014-04-01

... such salts, isomers, and salts of isomers is possible: (1) Fenfluramine 1670 (e) Lorcaserin. Any... salts of isomers is possible: (1) Lorcaserin 1625 (f) Stimulants. Unless specifically excepted or unless...

The 10/66 Dementia Research Group's fully operationalised DSM-IV dementia computerized diagnostic algorithm, compared with the 10/66 dementia algorithm and a clinician diagnosis: a population validation study

PubMed Central

Prince, Martin J; de Rodriguez, Juan Llibre; Noriega, L; Lopez, A; Acosta, Daisy; Albanese, Emiliano; Arizaga, Raul; Copeland, John RM; Dewey, Michael; Ferri, Cleusa P; Guerra, Mariella; Huang, Yueqin; Jacob, KS; Krishnamoorthy, ES; McKeigue, Paul; Sousa, Renata; Stewart, Robert J; Salas, Aquiles; Sosa, Ana Luisa; Uwakwa, Richard

2008-01-01

Background The criterion for dementia implicit in DSM-IV is widely used in research but not fully operationalised. The 10/66 Dementia Research Group sought to do this using assessments from their one phase dementia diagnostic research interview, and to validate the resulting algorithm in a population-based study in Cuba. Methods The criterion was operationalised as a computerised algorithm, applying clinical principles, based upon the 10/66 cognitive tests, clinical interview and informant reports; the Community Screening Instrument for Dementia, the CERAD 10 word list learning and animal naming tests, the Geriatric Mental State, and the History and Aetiology Schedule – Dementia Diagnosis and Subtype. This was validated in Cuba against a local clinician DSM-IV diagnosis and the 10/66 dementia diagnosis (originally calibrated probabilistically against clinician DSM-IV diagnoses in the 10/66 pilot study). Results The DSM-IV sub-criteria were plausibly distributed among clinically diagnosed dementia cases and controls. The clinician diagnoses agreed better with 10/66 dementia diagnosis than with the more conservative computerized DSM-IV algorithm. The DSM-IV algorithm was particularly likely to miss less severe dementia cases. Those with a 10/66 dementia diagnosis who did not meet the DSM-IV criterion were less cognitively and functionally impaired compared with the DSMIV confirmed cases, but still grossly impaired compared with those free of dementia. Conclusion The DSM-IV criterion, strictly applied, defines a narrow category of unambiguous dementia characterized by marked impairment. It may be specific but incompletely sensitive to clinically relevant cases. The 10/66 dementia diagnosis defines a broader category that may be more sensitive, identifying genuine cases beyond those defined by our DSM-IV algorithm, with relevance to the estimation of the population burden of this disorder. PMID:18577205

Involvement of DPP IV/CD26 in cutaneous wound healing process in mice.

PubMed

Baticic Pucar, Lara; Pernjak Pugel, Ester; Detel, Dijana; Varljen, Jadranka

2017-01-01

Dipeptidyl peptidase IV (DPP IV/CD26) is a widely distributed multifunctional protein that plays a significant role in different physiological as well as pathological processes having a broad spectrum of bioactive substrates and immunomodulative properties. It has potential influence on different processes crucial for wound healing, including cell adhesion, migration, apoptosis, and extracellular matrix degradation. However, despite its known enzymatic and immunomodulative functions, limited data characterize the role of DPP IV/CD26 in cutaneous wound healing mechanisms. The aim of this study was to investigate the process of wound healing in conditions of CD26 deficiency in order to obtain better insights on the role of DPP IV/CD26 in cutaneous regeneration. Experimental wounds were made on the dorsal part of CD26 deficient (CD26 -/- ) and wild-type mice (C57BL/6). The process of cutaneous wound healing was monitored on defined time schedule postwounding by macroscopic, microscopic, and biochemical analyses. Obtained results revealed a better rate of wound closure, revascularization and cell proliferation in CD26 -/- mice, with enhanced local expression of hypoxia-inducible factor 1α and vascular endothelial growth factor. CD26 deficiency induced prompt macrophage recruitment at the site of skin damage but did not influence mobilization of T-cells in comparison with wild-type mice. CD26 -/- mice have significantly higher values of IP-10 in serum and control skins compared with wild-type mice but values in wounds did not differ significantly on days 2, 4, and 7 of wound healing. DPP IV/CD26 activity was found to be decreased 4 days postwounding in serum and 2, 4, and 7 days postwounding in wounds of wild-type animals compared with control skins. These findings contribute to better understanding of wound healing mechanisms and could give a support in finding new therapeutic approaches for wound healing and tissue regeneration. © 2016 by the Wound Healing Society.

40 CFR 131.7 - Dispute resolution mechanism.

Code of Federal Regulations, 2010 CFR

2010-07-01

... parties, to study the problem and recommend an appropriate solution. (iv) The procedure and schedule for... dischargers, comparative risks to public health and the environment, economic impacts, present and historical...

40 CFR 131.7 - Dispute resolution mechanism.

Code of Federal Regulations, 2011 CFR

2011-07-01

... parties, to study the problem and recommend an appropriate solution. (iv) The procedure and schedule for... dischargers, comparative risks to public health and the environment, economic impacts, present and historical...

40 CFR 131.7 - Dispute resolution mechanism.

Code of Federal Regulations, 2014 CFR

2014-07-01

... parties, to study the problem and recommend an appropriate solution. (iv) The procedure and schedule for... dischargers, comparative risks to public health and the environment, economic impacts, present and historical...

40 CFR 131.7 - Dispute resolution mechanism.

Code of Federal Regulations, 2013 CFR

2013-07-01

... parties, to study the problem and recommend an appropriate solution. (iv) The procedure and schedule for... dischargers, comparative risks to public health and the environment, economic impacts, present and historical...

40 CFR 131.7 - Dispute resolution mechanism.

Code of Federal Regulations, 2012 CFR

2012-07-01

... parties, to study the problem and recommend an appropriate solution. (iv) The procedure and schedule for... dischargers, comparative risks to public health and the environment, economic impacts, present and historical...

ULA Delta IV Heavy Common Booster Cores for the Parker Solar Pro

NASA Image and Video Library

2017-07-28

Framed by a series of cabbage palms, a United Launch Alliance Delta IV Heavy common booster core is transported by truck to Cape Canaveral Air Force Station's Launch Complex 37 Horizontal Processing Facility after arriving at Port Canaveral. The Delta IV Heavy will launch NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

IV&V Project Assessment Process Validation

NASA Technical Reports Server (NTRS)

Driskell, Stephen

2012-01-01

The Space Launch System (SLS) will launch NASA's Multi-Purpose Crew Vehicle (MPCV). This launch vehicle will provide American launch capability for human exploration and travelling beyond Earth orbit. SLS is designed to be flexible for crew or cargo missions. The first test flight is scheduled for December 2017. The SLS SRR/SDR provided insight into the project development life cycle. NASA IV&V ran the standard Risk Based Assessment and Portfolio Based Risk Assessment to identify analysis tasking for the SLS program. This presentation examines the SLS System Requirements Review/System Definition Review (SRR/SDR), IV&V findings for IV&V process validation correlation to/from the selected IV&V tasking and capabilities. It also provides a reusable IEEE 1012 scorecard for programmatic completeness across the software development life cycle.

The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of New Psychiatric Diagnostic Modules and Risk Factors in a General Population Sample

PubMed Central

Ruan, W. June; Goldstein, Risë B.; Chou, S. Patricia; Smith, Sharon M.; Saha, Tulshi D.; Pickering, Roger P.; Dawson, Deborah A.; Huang, Boji; Stinson, Frederick S.; Grant, Bridget F.

2008-01-01

This study presents test-retest reliability statistics and information on internal consistency for new diagnostic modules and risk factor of alcohol, drug, and psychiatric disorders the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV). Test-retest statistics were derived from a random sample of 1,899 adults selected from 34,653 respondents who participated in the 2004–2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Internal consistency of continuous scales was assessed using the entire Wave 2 NESARC. Both test and retest interviews were conducted face-to-face. Test-retest and internal consistency results for diagnoses and symptom scales associated with posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and borderline, narcissistic, and schizotypal personality disorders were predominantly good (kappa > 0.63; ICC > 0.69; alpha > 0.75) and reliability for risk factor measures fell within the good to excellent range (intraclass correlations = 0.50–0.94; alpha = 0.64–0.90). The high degree of reliability found in this study suggests that new AUDADIS-IV diagnostic measures can be useful tools in research settings. The availability of highly reliable measures of risk factors of alcohol, drug, and psychiatric disorders will contribute to the validity of conclusions drawn from future research in the domains of substance use disorder and psychiatric epidemiology. PMID:17706375

Orion is Lifted for Mating with Delta IV

NASA Image and Video Library

2014-11-12

At Cape Canaveral Air Force Station's Launch Complex 37, United Launch Alliance engineers and technicians mate the agency's Orion spacecraft to its Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Arrival of the ULA Delta IV Heavy Common Booster Cores for the P

NASA Image and Video Library

2017-07-26

The United Launch Alliance (ULA) Mariner arrives at Port Canaveral in Florida carrying two of the three Delta IV Heavy Common Booster Cores for NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Second Stage & Port Common Booster Core for t

NASA Image and Video Library

2017-08-30

The United Launch Alliance Mariner arrives at Port Canaveral's Army Warf carrying the third Delta IV Heavy common booster core and second stage for NASA's upcoming Parker Solar Probe spacecraft. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

Arrival of the ULA Delta IV Heavy Common Booster Cores for the P

NASA Image and Video Library

2017-07-26

The United Launch Alliance (ULA) Mariner docks at Port Canaveral in Florida carrying two of the three Delta IV Heavy Common Booster Cores for NASA's upcoming Parker Solar Probe mission. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

ULA Delta IV Heavy Second Stage & Port Common Booster Core for t

NASA Image and Video Library

2017-08-26

The United Launch Alliance Mariner arrives at Port Canaveral's Army Warf carrying the third Delta IV Heavy common booster core and second stage for NASA's upcoming Parker Solar Probe spacecraft. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

Does oppositional defiant disorder have temperament and psychopathological profiles independent of attention deficit/hyperactivity disorder?

PubMed

Kim, Hyo-Won; Cho, Soo-Churl; Kim, Boong-Nyun; Kim, Jae-Won; Shin, Min-Sup; Yeo, Jin-Young

2010-01-01

Most studies on temperamental and behavioral/emotional characteristics of oppositional defiant disorder (ODD) did not rule out the effect of comorbid attention-deficit/hyperactivity disorder (ADHD). The main objective of this study was to identify the temperamental and psychopathological patterns of ODD independent of comorbid ADHD. We also aimed to compare the patterns of temperament and psychopathology between ODD with and without ADHD. Parents of 2673 students, randomly selected from 19 representative schools in Seoul, Korea, completed the Diagnostic Interview Schedule for Children Version IV. Among 118 children and adolescents with ODD diagnosed by the Diagnostic Interview Schedule for Children Version IV, the parents of 94 subjects (mean age, 10.4 +/- 3.0 years) and the parents of a random sample of 94 age- and gender-matched non-ODD/non-ADHD children and adolescents completed the parent's version of the Child Behavior Checklist (CBCL) and the Junior Temperament and Character Inventory. Subjects with ODD showed temperament and character profiles of high Novelty Seeking, low Self-directedness, and low Cooperativeness, a distinct pattern on the CBCL, and were at increased risk for anxiety and mood disorders compared to the controls after controlling for the effect of comorbid ADHD. The children and adolescents with both ODD and ADHD showed decreased levels of Persistence and Self-directedness and higher scores on 4 subscales of the CBCL (Anxious/Depressed, Attention Problems, Delinquent Behaviors, and Aggressive Behaviors) compared to those with ODD only. Oppositional defiant disorder is associated with specific temperamental and behavioral/emotional characteristics, independent of ADHD. Moreover, the results of this study support that co-occurring ADHD and ODD have differentially higher levels of behavioral and emotional difficulties. Copyright 2010 Elsevier Inc. All rights reserved.

The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act.

PubMed

Johnson, Matthew W; Griffiths, Roland R; Hendricks, Peter S; Henningfield, Jack E

2018-06-05

This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA). Research suggests the potential safety and efficacy of psilocybin in treating cancer-related psychiatric distress and substance use disorders, setting the occasion for this review. A more extensive assessment of abuse potential according to an 8-factor analysis would eventually be required to guide appropriate schedule placement. Psilocybin, like other 5-HT2A agonist classic psychedelics, has limited reinforcing effects, supporting marginal, transient non-human self-administration. Nonetheless, mushrooms with variable psilocybin content are used illicitly, with a few lifetime use occasions being normative among users. Potential harms include dangerous behavior in unprepared, unsupervised users, and exacerbation of mental illness in those with or predisposed to psychotic disorders. However, scope of use and associated harms are low compared to prototypical abused drugs, and the medical model addresses these concerns with dose control, patient screening, preparation and follow-up, and session supervision in a medical facility. (1) psilocybin has an abuse potential appropriate for CSA scheduling if approved as medicine; (2) psilocybin can provide therapeutic benefits that may support the development of an approvable New Drug Application (NDA) but further studies are required which this review describes; (3) adverse effects of medical psilocybin are manageable when administered according to risk management approaches; and (4) although further study is required, this review suggests that placement in Schedule IV may be appropriate if a psilocybin-containing medicine is approved. Copyright © 2018. Published by Elsevier Ltd.

Comparative erythropoietic effects of three vanadium compounds.

PubMed

Hogan, G R

2000-07-10

The biotoxic effects of vanadium are variable depending upon a number of factors including the oxidation state of the test compound. This study reports the effects of three vanadium compounds on peripheral erythrocytes. On day 0 female ICR mice received a single injection of vanadium chloride (V-III), vanadyl sulfate (V-IV), or sodium orthovandate (V-V). At scheduled intervals post-injection, the number of circulating erythrocytes [red blood cells per millimeter cubed (RBC/mm3)], reticulocyte percentages, and radioiron uptake percentages were determined and compared to mice receiving saline only. Data show that all three test substances promoted a significant lowering of RBC/mm3 beginning on day 1 for V-IV and V-V and on day 2 for V-III through day 4. The reticulocyte percentages increase followed the same time course as that of the peripheral RBC decrease. Peak reticulocytosis was noted on days 2 and 4 for all three vanadium-treated groups; for V-IV and V-V the increase continued to day 6. Radioiron data showed an erythropoietic stimulation by a significant increase in uptake percentages on days 4-6 after vanadium injections compared to saline-treated controls.

Investigation of effects of 60-Hz electric and magnetic fields on operant and social behavior and on the neuroendocrine system of nonhuman primates: Neuroendocrine portion of Experiment IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, W.R.; Rhodes, J.W.

1992-08-31

This quarterly report covers the neuroendocrine Portion of Experiment IV. Serum melatonin concentration was measured in individual baboons, each implanted with a chronically indwelling venous cannula. As in Experiment III the system of six automatic blood samplers was used to achieve undisturbed, 24 hr per day, simultaneous blood sampling from six individual subjects. The objective of the neuroendocrine portion of Experiment IV was to determine if 30 kV/m electric and 1.0 G magnetic field (E/MF) exposure produced a 50% decline in nocturnal serum melatonin concentration. Other groups of subjects were tested concurrently during Experiment IV to assess E/MF effects onmore » group social and individual operant behavior. The results of these experiments will be covered respectively in the next two quarterly reports. The results of Experiment IV, as was the case with the result of Experiments III and IIIA, provide little or no evidence that E/MF exposure, under the conditions of these experiments, affects nocturnal serum melatonin concentrations of nonhuman primates. Together the negative results of Experiments III, IIA and IV indicate that day-time exposure of primates to slow-onset/offset, regularly-scheduled E/MF does not produce melatonin suppression, strongly suggesting that such exposure would not affect human melatonin either. However, before concluding that E/MF exposure in general has no effect on primate melatonin, nightime exposure needs to be examined, and the possibility, suggested by the Pilot Experiment, that fast onset/offset, irregularly-scheduled E/MF can completely suppress melatonin needs to be investigated.« less

Investigation of effects of 60-Hz electric and magnetic fields on operant and social behavior and on the neuroendocrine system of nonhuman primates: Neuroendocrine portion of Experiment IV. Quarterly report No. 38

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, W.R.; Rhodes, J.W.

1992-08-31

This quarterly report covers the neuroendocrine Portion of Experiment IV. Serum melatonin concentration was measured in individual baboons, each implanted with a chronically indwelling venous cannula. As in Experiment III the system of six automatic blood samplers was used to achieve undisturbed, 24 hr per day, simultaneous blood sampling from six individual subjects. The objective of the neuroendocrine portion of Experiment IV was to determine if 30 kV/m electric and 1.0 G magnetic field (E/MF) exposure produced a 50% decline in nocturnal serum melatonin concentration. Other groups of subjects were tested concurrently during Experiment IV to assess E/MF effects onmore » group social and individual operant behavior. The results of these experiments will be covered respectively in the next two quarterly reports. The results of Experiment IV, as was the case with the result of Experiments III and IIIA, provide little or no evidence that E/MF exposure, under the conditions of these experiments, affects nocturnal serum melatonin concentrations of nonhuman primates. Together the negative results of Experiments III, IIA and IV indicate that day-time exposure of primates to slow-onset/offset, regularly-scheduled E/MF does not produce melatonin suppression, strongly suggesting that such exposure would not affect human melatonin either. However, before concluding that E/MF exposure in general has no effect on primate melatonin, nightime exposure needs to be examined, and the possibility, suggested by the Pilot Experiment, that fast onset/offset, irregularly-scheduled E/MF can completely suppress melatonin needs to be investigated.« less

KSC-2013-3797

NASA Image and Video Library

2013-09-27

CAPE CANAVERAL, Fla. – Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, the launch abort system, or LAS, components are horizontally stacked as processing continues for the Orion Exploration Flight Test-1 mission. Components of the LAS are the launch abort motor, the attitude control motor, the jettison motor and the fairing. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The LAS is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-3798

NASA Image and Video Library

2013-09-27

CAPE CANAVERAL, Fla. – Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, the launch abort system, or LAS, components are horizontally stacked as processing continues for the Orion Exploration Flight Test-1 mission. Components of the LAS are the launch abort motor, the attitude control motor, the jettison motor and the fairing. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The LAS is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Interrelationship between Autism Diagnostic Observation Schedule-Generic (ADOS-G), Autism Diagnostic Interview-Revised (ADI-R), and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) Classification in Children and Adolescents with Mental Retardation

ERIC Educational Resources Information Center

de Bildt, Annelies; Sytema, Sjoerd; Ketelaars, Cees; Kraijer, Dirk; Mulder, Erik; Volkmar, Fred; Minderaa, Ruud

2004-01-01

The interrelationship between the Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedule-Generic (ADOS-G) and clinical classification was studied in 184 children and adolescents with Mental Retardation (MR). The agreement between the ADI-R and ADOS-G was fair, with a substantial difference between younger and older…

OFFICIAL PORTRAIT - STS-51A CREW

NASA Image and Video Library

1984-08-20

S84-40082 (August 1984) --- These five astronauts are scheduled to fly aboard the Space Shuttle Discovery on Mission STS-51A for NASA. The mission is scheduled for early November 1984. Astronaut Frederick H. (Rick) Hauck, seated, is crew commander. Astronaut David M. Walker, pilot, stands next to the Eagle, 51-A mascot. Others on the back row, left-to-right, are astronauts Dale A. Gardner, Anna L. Fisher and Joseph P. Allen IV, all mission specialists.

Controversies in rabies vaccination.

PubMed

Ghosh, Tapan Kr

2003-06-01

Rabies is a cent per cent fatal disease and there should not be any controversy in giving rabies vaccine to the victims. WHO has fixed schedules for doses for both pre and post-exposure in different category of cases, which also help us to avoid all controversies. But controversies arise in five main areas, which are related to the strategies of rabies prevention. These are: (i) Replacing use of NTV by MTCV. (ii) Intradermal schedule of MTCV, in place of Essen protocol of 5 i.m. doses to reduce the cost. (iii) Acceptability and inclusion of pre-exposure doses of MTCV in the immunization schedule of children as additional vaccine (iv) Schedule for re-exposure in already post-exposure vaccinated cases and schedule for exposure in pre-exposure vaccinated cases. (v) Uses of RIG in WHO category III cases. If these controversial issues are considered scientifically, rabies prophylaxis will see the light of success.

Evolution of Query Optimization Methods

NASA Astrophysics Data System (ADS)

Hameurlain, Abdelkader; Morvan, Franck

Query optimization is the most critical phase in query processing. In this paper, we try to describe synthetically the evolution of query optimization methods from uniprocessor relational database systems to data Grid systems through parallel, distributed and data integration systems. We point out a set of parameters to characterize and compare query optimization methods, mainly: (i) size of the search space, (ii) type of method (static or dynamic), (iii) modification types of execution plans (re-optimization or re-scheduling), (iv) level of modification (intra-operator and/or inter-operator), (v) type of event (estimation errors, delay, user preferences), and (vi) nature of decision-making (centralized or decentralized control).

Using type IV Pearson distribution to calculate the probabilities of underrun and overrun of lists of multiple cases.

PubMed

Wang, Jihan; Yang, Kai

2014-07-01

An efficient operating room needs both little underutilised and overutilised time to achieve optimal cost efficiency. The probabilities of underrun and overrun of lists of cases can be estimated by a well defined duration distribution of the lists. To propose a method of predicting the probabilities of underrun and overrun of lists of cases using Type IV Pearson distribution to support case scheduling. Six years of data were collected. The first 5 years of data were used to fit distributions and estimate parameters. The data from the last year were used as testing data to validate the proposed methods. The percentiles of the duration distribution of lists of cases were calculated by Type IV Pearson distribution and t-distribution. Monte Carlo simulation was conducted to verify the accuracy of percentiles defined by the proposed methods. Operating rooms in John D. Dingell VA Medical Center, United States, from January 2005 to December 2011. Differences between the proportion of lists of cases that were completed within the percentiles of the proposed duration distribution of the lists and the corresponding percentiles. Compared with the t-distribution, the proposed new distribution is 8.31% (0.38) more accurate on average and 14.16% (0.19) more accurate in calculating the probabilities at the 10th and 90th percentiles of the distribution, which is a major concern of operating room schedulers. The absolute deviations between the percentiles defined by Type IV Pearson distribution and those from Monte Carlo simulation varied from 0.20  min (0.01) to 0.43  min (0.03). Operating room schedulers can rely on the most recent 10 cases with the same combination of surgeon and procedure(s) for distribution parameter estimation to plan lists of cases. Values are mean (SEM). The proposed Type IV Pearson distribution is more accurate than t-distribution to estimate the probabilities of underrun and overrun of lists of cases. However, as not all the individual case durations followed log-normal distributions, there was some deviation from the true duration distribution of the lists.

Randomized, Controlled Trial of Dexamethasone Versus Dexamethasone Plus Hydrocortisone as Prophylaxis for Hypersensitivity Reactions Due to Paclitaxel Treatment for Gynecologic Cancer.

PubMed

Jeerakornpassawat, Dhammapoj; Suprasert, Prapaporn

2017-10-01

The aim of this study was to assess intravenous hydrocortisone (HCT) added to standard dexamethasone (DXM) prophylaxis for paclitaxel-associated hypersensitivity reactions (HSRs). Paclitaxel naives scheduled for 6 cycles of paclitaxel (plus platinum) were randomized to DXM alone (20 mg intravenously [IV]) versus DXM plus HCT (100 mg IV) as premedication including chlorpheniramine (10 mg IV), diphenhydramine (25 mg orally), and ranitidine (50 mg IV) 30 minutes before infusion. Clinic nurses observed for HSRs. Groups were well balanced for cancer type, stage, drug allergy, chemotherapy naivete, mean age, body mass index, and paclitaxel dose. The 44 DXM controls underwent 213 cycles and the 42 investigational DXM plus HCT group 192 per protocol cycles. Hypersensitivity reactions were observed among 9 (4.2%) DXM only cycles compared with 1 (0.5%) among DXM plus HCT cycles (P = 0.022). Hypersensitivity reactions occurred in 8 (18%) DXM only patients and in 1 (2.4%) among those correctly receiving DXM plus HCT (P = 0.030). All HSRs occurred in cycles 1 to 3, within 10 to 40 minutes after infusion initiation, and peaked in cycle 2 (5/39) for DXM recipients and in cycle 3 (1/30) for DXM plus HCT. Hypersensitivity reaction severity was grade 1 in 3 DXM only recipients and grade 2 in 6 DXM and 1 DXM plus HCT. A sole grade 3 HSR was in an intention-to-treat DXM-HCT patient, who erroneously received no HCT. Hypersensitivity reaction symptoms were facial flushing (8 episodes), dyspnea (7), palmar rash (1), and transient hypotension (1). Paclitaxel infusion was suspended for treatment of HSRs; in all cases, symptoms mitigated and infusion successfully restarted for the remaining dose. Adding HCT to routine DXM prophylaxis significantly decreased paclitaxel HSR frequency.

Under the surface: the dynamic interpersonal and affective world of psychopathic high-security and detention prisoners.

PubMed

Gullhaugen, Aina Sundt; Nøttestad, Jim Aage

2012-09-01

The present study yields an in-depth examination of the interpersonal and affective world of high-security and detention prisoners with possible (Psychopathy Checklist: Screening Version [PCL:SV] ≥ 13) and strong (PCL:SV ≥ 18) indications of psychopathy. A group of male inmates (n = 16) was compared with noncriminal and non-personality disordered controls (n = 35) on measures of self and other (Young Schema Questionnaire-Short Form [YSQ-SF], Inventory of Interpersonal Problems-Circumplex Scales [IIP-C]), and the experience and regulation of affect (Positive and Negative Affect Schedule [PANAS], Emotion Control Questionnaire 2 [ECQ2]). Results confirm the established grandiose, dominant, and callous characteristics of the psychopath (PCL:SV, Structured Clinical Interview for DSM-IV Axis II Disorders [SCID-II], DSM-IV and ICD-10 Personality Questionnaire [DIP-Q], IIP-C), while demonstrating personal distress and important nuances and variations in psychopathic offenders' interpersonal and affective functioning (YSQ-SF, PANAS, ECQ2, SCID-II, DIP-Q). These preliminary findings support, expand, and challenge the ordinary portrayal of the psychopath and, if replicated in larger samples, point to a need for an expansion or reformulation of the concept, measurement, and treatment of psychopathy.

Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study.

PubMed

Arıkan, Müge; Aslan, Bilge; Arıkan, Osman; Horasanlı, Eyüp; But, Abdulkadir

2016-01-01

To compare the effects of magnesium sulfate and ketamine on postoperative pain and total morphine consumption in a placebo-controlled design. One hundred and twenty women scheduled for total abdominal hysterectomy were included in this prospective, randomized, double-blind study. Postoperatively, when the Numeric Pain Rating Scale (NPRS) was four or more, IV-PCA morphine was applied to all patients. The patients were randomized into three groups: Group K ketamine, Group M magnesium, and Group C saline received as infusion. Total morphine consumption for 48h, pain scores, adverse effects, and patients' satisfaction were evaluated. Total morphine consumption was significantly lower in Group K (32.6±9.2 mg) than in Group M (58.9±6.5 mg) and in Group C (65.7±8.2 mg). The satisfaction level of patients in Group K was higher than the other two groups (p<0.05). Pruritus and nausea were observed more frequently in Group C. CONCLUSİON: The addition of ketamine to IV-PCA morphine reduces the total consumption of morphine without psychotic effects; however, magnesium did not influence morphine consumption.

Attachment styles and psychopathology among adolescent children of parents with bipolar disorder.

PubMed

Erkan, Mustafa; Gencoglan, Salih; Akguc, Leyla; Ozatalay, Esin; Fettahoglu, Emine Cigil

2015-04-16

The aim of this study was to compare attachment styles and psychopathology in adolescent children of parents with bipolar disorder (BD) with a healthy control group. We studied 25 adolescents who had at least 1 parent with BD (BD group) and 28 adolescents who had no parents with BD (control group). The adolescent participants were between the ages of 12 and 17 years. We used the Adolescent Relationship Scales Questionnaire (A-RSQ) for the adolescents in the BD vs. control groups, and we used the Schedule for Affective Disorders and Schizophrenia for School-age Children - present and lifetime version (K-SADS-PL). We used the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version for each parent of adolescents in the BD and control groups to rule out psychopathologies. Attachment styles of participants were assessed according to A-RSQ, dismissing attachment style scores of adolescents in BD group were found significantly higher compared to the healthy control group (p<0.05). As a result of the assessments, 12 adolescents (48%) out of 25 in the BD group and 5 adolescents (18%) out of 28 in the control group were given DSM-IV Axis I diagnosis, which is a statistically significant result (p<0.05). However, when psychiatric diagnoses were assessed separately, the difference was not statistically significant. We found that the adolescent children of parents with BD have increased risk of developing mental illnesses, and that these adolescents adopt dismissing attachment styles.

Orion is Lifted for Mating with Delta IV

NASA Image and Video Library

2014-11-12

At Cape Canaveral Air Force Station's Launch Complex 37, United Launch Alliance engineers and technicians prepare to mate the agency's Orion spacecraft to its Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Orion is Lifted for Mating with Delta IV

NASA Image and Video Library

2014-11-12

At Cape Canaveral Air Force Station's Launch Complex 37, United Launch Alliance engineers and technicians prepare to lift the agency's Orion spacecraft for mounting atop its Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Orion is Lifted for Mating with Delta IV

NASA Image and Video Library

2014-11-12

At Cape Canaveral Air Force Station's Launch Complex 37, United Launch Alliance engineers and technicians begin lifting the agency's Orion spacecraft for mounting atop its Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Dysfunctional family environment in affected versus unaffected offspring of parents with bipolar disorder.

PubMed

Ferreira, Guilherme S; Moreira, Carolina R L; Kleinman, Ana; Nader, Edmir C G P; Gomes, Bernardo Carramão; Teixeira, Ana Maria A; Rocca, Cristiana C Almeida; Nicoletti, Mark; Soares, Jair C; Busatto, Geraldo F; Lafer, Beny; Caetano, Sheila C

2013-11-01

Children of parents with bipolar disorder (BD) are at heightened risk for developing mood and other psychiatric disorders. We proposed to evaluate the environment of families with at least one parent with BD type I (BDF) with affected offspring (aBDF) and unaffected offspring (uBDF) compared with control families without a history of DSM-IV Axis I disorder (CF). We used the Family Environment Scale (FES) to evaluate 47 BDF (aBDF + uBDF) and 30 CF. Parents were assessed through the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Diagnosis of the offspring was determined through the Schedule for Affective Disorders and Schizophrenia for School-Age Children/Present and Lifetime Version (K-SADS-PL) interview. There were statistically significant differences between aBDF, uBDF and CF in cohesion (p = 0.003), intellectual-cultural orientation (p = 0.01), active-recreational orientation (p = 0.007), conflict (p = 0.001), control (p = 0.01), moral-religious emphasis (p = 0.01) and organization (p = 0.001). The aBDF showed higher levels of control (p = 0.02) when compared to the uBDF. Families with a BD parent presented more dysfunctional interactions among members. Moreover, the presence of BD or other psychiatric disorders in the offspring of parents with BD is associated with higher levels of control. These results highlight the relevance of psychosocial interventions to improve resilience and family interactions.

5 CFR 1603.3 - Service requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5316; (3) A position placed in level IV or level V of the Executive Schedule, pursuant to 5 U.S.C. 5317; (4) A position in the Executive Branch which is excepted from the competitive service by the Office...

5 CFR 1603.3 - Service requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5316; (3) A position placed in level IV or level V of the Executive Schedule, pursuant to 5 U.S.C. 5317; (4) A position in the Executive Branch which is excepted from the competitive service by the Office...

The use of alcohol use disorders identification test (AUDIT) in detecting alcohol use disorder and risk drinking in the general population: validation of AUDIT using schedules for clinical assessment in neuropsychiatry.

PubMed

Lundin, Andreas; Hallgren, Mats; Balliu, Natalja; Forsell, Yvonne

2015-01-01

The alcohol use disorders identification test (AUDIT) and AUDIT-Consumption (AUDIT-C) are commonly used in population surveys but there are few validations studies in the general population. Validity should be estimated in samples close to the targeted population and setting. This study aims to validate AUDIT and AUDIT-C in a general population sample (PART) in Stockholm, Sweden. We used a general population subsample age 20 to 64 that answered a postal questionnaire including AUDIT who later participated in a psychiatric interview (n = 1,093). Interviews using Schedules for Clinical Assessment in Neuropsychiatry was used as criterion standard. Diagnoses were set according to the fourth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Agreement between the diagnostic test and criterion standard was measured with area under the receiver operator characteristics curve (AUC). A total of 1,086 (450 men and 636 women) of the interview participants completed AUDIT. There were 96 individuals with DSM-IV-alcohol dependence, 36 DSM-IV-Alcohol Abuse, and 153 Risk drinkers. AUCs were for DSM-IV-alcohol use disorder 0.90 (AUDIT-C 0.85); DSM-IV-dependence 0.94 (AUDIT-C 0.89); risk drinking 0.80 (AUDIT-C 0.80); and any criterion 0.87 (AUDIT-C 0.84). In this general population sample, AUDIT and AUDIT-C performed outstanding or excellent in identifying dependency, risk drinking, alcohol use disorder, any disorder, or risk drinking. Copyright © 2015 by the Research Society on Alcoholism.

At War in the Shadow of Vietnam: United States Military Aid to the Royal LAO Government 1955-75

DTIC Science & Technology

1991-05-01

number of other people interrupted their busy schedules to read drafts of this dissertation. Professor William M. iv Leary, University of Georgia... busy schedule to talk with me about the activities of the CIA and Air America in Laos. His comments on guerilla warfare were extremely vi valuable...Vietnam and the Mekong valley. These features have also given the plain an important strategic value. For centuries, armies have crossed through the

Efficacy of Rhodotorula glutinis and Spirulina platensis carotenoids in immunopotentiation of mice infected with Candida albicans SC5314 and Pseudomonas aeruginosa 35.

PubMed

El-Sheekh, M M; Mahmoud, Y A-G; Abo-Shady, A M; Hamza, W

2010-01-01

Enhancement of the immune response leading to protection against bacterial and fungal infections was shown using different schedules of immunization with microbial pigments and a polysaccharide. The group of mice given carotenoids of Rhodotorula glutinis (preparation I) and polysaccharide of Spitulina platensis (IV) survived for 2 weeks after Pseudomonas aeruginosa infection. The groups of mice given carotenoids (I), polysaccharide (IV), I+IV and with the crude phycocyanin of S. platensis (III)+IV survived for 2 weeks after Candida albicans infection. All other groups recorded a maximum level of mortality reaching 2 mice per group either after immunization or post-infection. Adding the carotenoids, phycocyanin and polysaccharides to food as additives might therefore enhance the human immune response against microbial infections.

32 CFR 199.18 - Uniform HMO Benefit.

Code of Federal Regulations, 2012 CFR

2012-07-01

... schedule, including frequency or age specifications for: (i) Laboratory and x-ray tests, including blood lead, rubella, cholesterol, fecal occult blood testing, and mammography; (ii) Pap smears; (iii) Eye exams; (iv) Immunizations; (v) Periodic health promotion and disease prevention exams; (vi) Blood...

32 CFR 199.18 - Uniform HMO Benefit.

Code of Federal Regulations, 2011 CFR

2011-07-01

... schedule, including frequency or age specifications for: (i) Laboratory and x-ray tests, including blood lead, rubella, cholesterol, fecal occult blood testing, and mammography; (ii) Pap smears; (iii) Eye exams; (iv) Immunizations; (v) Periodic health promotion and disease prevention exams; (vi) Blood...

32 CFR 199.18 - Uniform HMO Benefit.

Code of Federal Regulations, 2013 CFR

2013-07-01

... schedule, including frequency or age specifications for: (i) Laboratory and x-ray tests, including blood lead, rubella, cholesterol, fecal occult blood testing, and mammography; (ii) Pap smears; (iii) Eye exams; (iv) Immunizations; (v) Periodic health promotion and disease prevention exams; (vi) Blood...

Safety and immunogenicity of a monovalent MF59®-adjuvanted A/H1N1 vaccine in HIV-infected children and young adults.

PubMed

Palma, Paolo; Romiti, Maria Luisa; Bernardi, Stefania; Pontrelli, Giuseppe; Mora, Nadia; Santilli, Veronica; Tchidjou, Hyppolite Kuekou; Aquilani, Angela; Cotugno, Nicola; Alghisi, Federico; Lucidi, Vincenzina; Rossi, Paolo; Douagi, Iyadh

2012-03-01

This Phase IV study evaluated the safety and immunogenicity of a two-dose, MF59®-adjuvanted (Novartis Vaccines, Marburg, Germany), monovalent, A/H1N1 pandemic influenza vaccination schedule in Human Immunodeficiency Virus (HIV) positive children and young adults. A total of 83 children infected with HIV-1, and 37 non-immunocompromised, age-matched controls were enrolled. All participants received two vaccine doses administered three weeks apart. Antibody responses were assessed by haemagglutination assay at baseline, three weeks after each vaccine dose, and six months after immunization. Vaccines were evaluated according to European influenza vaccine licensure criteria. The investigational vaccine was well tolerated. After the first vaccine dose, seroconversion rates were significantly lower in HIV-positive patients (60%) than controls (82%), with GMTs of 419 and 600, respectively. No significant differences in seroconversion rates were observed between the two study groups in response to the second vaccine dose. Persisting antibody titers were similar for both HIV-positive and non-infected controls, six months after immunization. One dose of MF59-adjuvanted vaccine was sufficient to provide adequate levels of seroprotection against A/H1N1 influenza disease in HIV-positive children. However, a two-dose vaccination schedule may be optimal for this population. Copyright © 2011 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

Efficacy of a single 40-mg intravenous dose of parecoxib for postoperative pain control after elective cesarean delivery: A double-blind randomized placebo-controlled trial.

PubMed

Inthigood, Nittaya; Lertbunnaphong, Tripop; Jaishuen, Atthapon

2017-01-01

The aim of this study was to determine the efficacy of a single 40-mg intravenous (i.v.) dose of parecoxib as an adjunctive analgesia to intrathecal morphine after elective cesarean delivery (CD). A total of 82 low-risk term pregnant women who were scheduled for elective CD during the June 2014-June 2015 study period were enrolled. Two hours after surgery, subjects were randomly assigned to receive either i.v. injection of 2 mL (40 mg) parecoxib (study group; n = 41) or 2 mL normal saline solution (control group; n = 41). Patient randomization into groups was determined by the hospital's central computer system. Outcome measurements included total postoperative supplemental meperidine consumption, recorded pain score by numeric pain rating scale at 6, 12, 18, and 24 h, postoperatively, and patient satisfaction. Patient characteristics and pregnancy outcomes were comparable between groups. Total postoperative meperidine consumption was not significantly different between groups (12.7 ± 18.8 mg vs 8.3 ± 16.7 mg; P > 0.05). Compared with control, the study group was significantly less likely to experience moderate to severe postoperative pain (score ≥ 4) at 6 h (0% vs 21.9%; P = 0.002). Study group patients reported higher satisfaction than control group patients (median score: 8 vs 6; P < 0.01). No patients in either group reported adverse effects from their assigned intervention. Parecoxib did not demonstrate effectiveness in reducing patient requirement for supplementary meperidine after CD. However, administration of a single 40-mg dose of i.v. parecoxib after elective CD demonstrated effectiveness in reducing pain scores, with a resulting increase in patient satisfaction. © 2016 Japan Society of Obstetrics and Gynecology.

Sloan Digital Sky Survey IV: Mapping the Milky Way, nearby galaxies, and the distant universe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanton, Michael R.; Bershady, Matthew A.; Abolfathi, Bela

Here, we describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (medianmore » $$z\\sim 0.03$$). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between $$z\\sim 0.6$$ and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.« less

Sloan Digital Sky Survey IV: Mapping the Milky Way, nearby galaxies, and the distant universe

DOE PAGES

Blanton, Michael R.; Bershady, Matthew A.; Abolfathi, Bela; ...

2017-06-29

Here, we describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (medianmore » $$z\\sim 0.03$$). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between $$z\\sim 0.6$$ and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.« less

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

NASA Astrophysics Data System (ADS)

Blanton, Michael R.; Bershady, Matthew A.; Abolfathi, Bela; Albareti, Franco D.; Allende Prieto, Carlos; Almeida, Andres; Alonso-García, Javier; Anders, Friedrich; Anderson, Scott F.; Andrews, Brett; Aquino-Ortíz, Erik; Aragón-Salamanca, Alfonso; Argudo-Fernández, Maria; Armengaud, Eric; Aubourg, Eric; Avila-Reese, Vladimir; Badenes, Carles; Bailey, Stephen; Barger, Kathleen A.; Barrera-Ballesteros, Jorge; Bartosz, Curtis; Bates, Dominic; Baumgarten, Falk; Bautista, Julian; Beaton, Rachael; Beers, Timothy C.; Belfiore, Francesco; Bender, Chad F.; Berlind, Andreas A.; Bernardi, Mariangela; Beutler, Florian; Bird, Jonathan C.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blomqvist, Michael; Bolton, Adam S.; Boquien, Médéric; Borissova, Jura; van den Bosch, Remco; Bovy, Jo; Brandt, William N.; Brinkmann, Jonathan; Brownstein, Joel R.; Bundy, Kevin; Burgasser, Adam J.; Burtin, Etienne; Busca, Nicolás G.; Cappellari, Michele; Delgado Carigi, Maria Leticia; Carlberg, Joleen K.; Carnero Rosell, Aurelio; Carrera, Ricardo; Chanover, Nancy J.; Cherinka, Brian; Cheung, Edmond; Gómez Maqueo Chew, Yilen; Chiappini, Cristina; Doohyun Choi, Peter; Chojnowski, Drew; Chuang, Chia-Hsun; Chung, Haeun; Cirolini, Rafael Fernando; Clerc, Nicolas; Cohen, Roger E.; Comparat, Johan; da Costa, Luiz; Cousinou, Marie-Claude; Covey, Kevin; Crane, Jeffrey D.; Croft, Rupert A. C.; Cruz-Gonzalez, Irene; Garrido Cuadra, Daniel; Cunha, Katia; Damke, Guillermo J.; Darling, Jeremy; Davies, Roger; Dawson, Kyle; de la Macorra, Axel; Dell'Agli, Flavia; De Lee, Nathan; Delubac, Timothée; Di Mille, Francesco; Diamond-Stanic, Aleks; Cano-Díaz, Mariana; Donor, John; Downes, Juan José; Drory, Niv; du Mas des Bourboux, Hélion; Duckworth, Christopher J.; Dwelly, Tom; Dyer, Jamie; Ebelke, Garrett; Eigenbrot, Arthur D.; Eisenstein, Daniel J.; Emsellem, Eric; Eracleous, Mike; Escoffier, Stephanie; Evans, Michael L.; Fan, Xiaohui; Fernández-Alvar, Emma; Fernandez-Trincado, J. G.; Feuillet, Diane K.; Finoguenov, Alexis; Fleming, Scott W.; Font-Ribera, Andreu; Fredrickson, Alexander; Freischlad, Gordon; Frinchaboy, Peter M.; Fuentes, Carla E.; Galbany, Lluís; Garcia-Dias, R.; García-Hernández, D. A.; Gaulme, Patrick; Geisler, Doug; Gelfand, Joseph D.; Gil-Marín, Héctor; Gillespie, Bruce A.; Goddard, Daniel; Gonzalez-Perez, Violeta; Grabowski, Kathleen; Green, Paul J.; Grier, Catherine J.; Gunn, James E.; Guo, Hong; Guy, Julien; Hagen, Alex; Hahn, ChangHoon; Hall, Matthew; Harding, Paul; Hasselquist, Sten; Hawley, Suzanne L.; Hearty, Fred; Gonzalez Hernández, Jonay I.; Ho, Shirley; Hogg, David W.; Holley-Bockelmann, Kelly; Holtzman, Jon A.; Holzer, Parker H.; Huehnerhoff, Joseph; Hutchinson, Timothy A.; Hwang, Ho Seong; Ibarra-Medel, Héctor J.; da Silva Ilha, Gabriele; Ivans, Inese I.; Ivory, KeShawn; Jackson, Kelly; Jensen, Trey W.; Johnson, Jennifer A.; Jones, Amy; Jönsson, Henrik; Jullo, Eric; Kamble, Vikrant; Kinemuchi, Karen; Kirkby, David; Kitaura, Francisco-Shu; Klaene, Mark; Knapp, Gillian R.; Kneib, Jean-Paul; Kollmeier, Juna A.; Lacerna, Ivan; Lane, Richard R.; Lang, Dustin; Law, David R.; Lazarz, Daniel; Lee, Youngbae; Le Goff, Jean-Marc; Liang, Fu-Heng; Li, Cheng; Li, Hongyu; Lian, Jianhui; Lima, Marcos; Lin, Lihwai; Lin, Yen-Ting; Bertran de Lis, Sara; Liu, Chao; de Icaza Lizaola, Miguel Angel C.; Long, Dan; Lucatello, Sara; Lundgren, Britt; MacDonald, Nicholas K.; Deconto Machado, Alice; MacLeod, Chelsea L.; Mahadevan, Suvrath; Geimba Maia, Marcio Antonio; Maiolino, Roberto; Majewski, Steven R.; Malanushenko, Elena; Malanushenko, Viktor; Manchado, Arturo; Mao, Shude; Maraston, Claudia; Marques-Chaves, Rui; Masseron, Thomas; Masters, Karen L.; McBride, Cameron K.; McDermid, Richard M.; McGrath, Brianne; McGreer, Ian D.; Medina Peña, Nicolás; Melendez, Matthew; Merloni, Andrea; Merrifield, Michael R.; Meszaros, Szabolcs; Meza, Andres; Minchev, Ivan; Minniti, Dante; Miyaji, Takamitsu; More, Surhud; Mulchaey, John; Müller-Sánchez, Francisco; Muna, Demitri; Munoz, Ricardo R.; Myers, Adam D.; Nair, Preethi; Nandra, Kirpal; Correa do Nascimento, Janaina; Negrete, Alenka; Ness, Melissa; Newman, Jeffrey A.; Nichol, Robert C.; Nidever, David L.; Nitschelm, Christian; Ntelis, Pierros; O'Connell, Julia E.; Oelkers, Ryan J.; Oravetz, Audrey; Oravetz, Daniel; Pace, Zach; Padilla, Nelson; Palanque-Delabrouille, Nathalie; Alonso Palicio, Pedro; Pan, Kaike; Parejko, John K.; Parikh, Taniya; Pâris, Isabelle; Park, Changbom; Patten, Alim Y.; Peirani, Sebastien; Pellejero-Ibanez, Marcos; Penny, Samantha; Percival, Will J.; Perez-Fournon, Ismael; Petitjean, Patrick; Pieri, Matthew M.; Pinsonneault, Marc; Pisani, Alice; Poleski, Radosław; Prada, Francisco; Prakash, Abhishek; Queiroz, Anna Bárbara de Andrade; Raddick, M. Jordan; Raichoor, Anand; Barboza Rembold, Sandro; Richstein, Hannah; Riffel, Rogemar A.; Riffel, Rogério; Rix, Hans-Walter; Robin, Annie C.; Rockosi, Constance M.; Rodríguez-Torres, Sergio; Roman-Lopes, A.; Román-Zúñiga, Carlos; Rosado, Margarita; Ross, Ashley J.; Rossi, Graziano; Ruan, John; Ruggeri, Rossana; Rykoff, Eli S.; Salazar-Albornoz, Salvador; Salvato, Mara; Sánchez, Ariel G.; Aguado, D. S.; Sánchez-Gallego, José R.; Santana, Felipe A.; Santiago, Basílio Xavier; Sayres, Conor; Schiavon, Ricardo P.; da Silva Schimoia, Jaderson; Schlafly, Edward F.; Schlegel, David J.; Schneider, Donald P.; Schultheis, Mathias; Schuster, William J.; Schwope, Axel; Seo, Hee-Jong; Shao, Zhengyi; Shen, Shiyin; Shetrone, Matthew; Shull, Michael; Simon, Joshua D.; Skinner, Danielle; Skrutskie, M. F.; Slosar, Anže; Smith, Verne V.; Sobeck, Jennifer S.; Sobreira, Flavia; Somers, Garrett; Souto, Diogo; Stark, David V.; Stassun, Keivan; Stauffer, Fritz; Steinmetz, Matthias; Storchi-Bergmann, Thaisa; Streblyanska, Alina; Stringfellow, Guy S.; Suárez, Genaro; Sun, Jing; Suzuki, Nao; Szigeti, Laszlo; Taghizadeh-Popp, Manuchehr; Tang, Baitian; Tao, Charling; Tayar, Jamie; Tembe, Mita; Teske, Johanna; Thakar, Aniruddha R.; Thomas, Daniel; Thompson, Benjamin A.; Tinker, Jeremy L.; Tissera, Patricia; Tojeiro, Rita; Hernandez Toledo, Hector; de la Torre, Sylvain; Tremonti, Christy; Troup, Nicholas W.; Valenzuela, Octavio; Martinez Valpuesta, Inma; Vargas-González, Jaime; Vargas-Magaña, Mariana; Vazquez, Jose Alberto; Villanova, Sandro; Vivek, M.; Vogt, Nicole; Wake, David; Walterbos, Rene; Wang, Yuting; Weaver, Benjamin Alan; Weijmans, Anne-Marie; Weinberg, David H.; Westfall, Kyle B.; Whelan, David G.; Wild, Vivienne; Wilson, John; Wood-Vasey, W. M.; Wylezalek, Dominika; Xiao, Ting; Yan, Renbin; Yang, Meng; Ybarra, Jason E.; Yèche, Christophe; Zakamska, Nadia; Zamora, Olga; Zarrouk, Pauline; Zasowski, Gail; Zhang, Kai; Zhao, Gong-Bo; Zheng, Zheng; Zheng, Zheng; Zhou, Xu; Zhou, Zhi-Min; Zhu, Guangtun B.; Zoccali, Manuela; Zou, Hu

2017-07-01

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z˜ 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z˜ 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.

Reinforcing effectiveness of nicotine in nonhuman primates: effects of nicotine dose and history of nicotine self-administration.

PubMed

Kohut, Stephen J; Bergman, Jack

2016-07-01

Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. Adult rhesus macaques (N = 6) self-administered intravenous (IV) nicotine (0.001-0.1 mg/kg) under a fixed-ratio (FR)1 schedule of reinforcement during daily 90-min sessions. Next, the demand function relating drug intake and response cost was determined by increasing the FR across sessions during the availability of each of several unit doses of nicotine (0.0032-0.032 mg/kg/inj). The reinforcing effects of 0.01 mg/kg/inj cocaine and 1 g banana-flavored food pellets were also determined under similar testing conditions. Finally, the nicotine demand function was re-determined after approximately 8 months of daily IV nicotine self-administration. IV nicotine self-administration followed an inverted U-shaped pattern, with the peak number of injections maintained by 0.0032 mg/kg/inj. Self-administration of each reinforcer (food pellets, IV cocaine, and IV nicotine) decreased as FR size increased. Application of the exponential model of demand showed that demand elasticity for nicotine was (1) dose-dependent and lowest for 0.0032 mg/kg/inj; (2) for 0.0032 mg/kg/inj, similar to that of food pellets and significantly higher than cocaine; and (3) decreased after 8 months of daily nicotine self-administration. These data show that, though high levels of nicotine self-administration can be achieved under simple FR schedules in nonhuman primates, its reinforcing effectiveness is dose-related but limited and may increase over time.

21 CFR 1306.21 - Requirement of prescription.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Substances Listed in Schedules III, IV, and V § 1306.21 Requirement of prescription. (a) A pharmacist may... individual practitioner and promptly reduced to writing by the pharmacist containing all information required... agent to the institutional practitioner-pharmacist, an electronic prescription that meets the...

21 CFR 1306.21 - Requirement of prescription.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Substances Listed in Schedules III, IV, and V § 1306.21 Requirement of prescription. (a) A pharmacist may... individual practitioner and promptly reduced to writing by the pharmacist containing all information required... agent to the institutional practitioner-pharmacist, an electronic prescription that meets the...

21 CFR 1306.21 - Requirement of prescription.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Substances Listed in Schedules III, IV, and V § 1306.21 Requirement of prescription. (a) A pharmacist may... individual practitioner and promptly reduced to writing by the pharmacist containing all information required... agent to the institutional practitioner-pharmacist, an electronic prescription that meets the...

21 CFR 1306.21 - Requirement of prescription.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Substances Listed in Schedules III, IV, and V § 1306.21 Requirement of prescription. (a) A pharmacist may... individual practitioner and promptly reduced to writing by the pharmacist containing all information required... agent to the institutional practitioner-pharmacist, an electronic prescription that meets the...

Attachment Styles and Psychopathology among Adolescent Children of Parents with Bipolar Disorder

PubMed Central

Erkan, Mustafa; Gencoglan, Salih; Akguc, Leyla; Ozatalay, Esin; Fettahoglu, Emine Cigil

2015-01-01

Background The aim of this study was to compare attachment styles and psychopathology in adolescent children of parents with bipolar disorder (BD) with a healthy control group. Material/Methods We studied 25 adolescents who had at least 1 parent with BD (BD group) and 28 adolescents who had no parents with BD (control group). The adolescent participants were between the ages of 12 and 17 years. We used the Adolescent Relationship Scales Questionnaire (A-RSQ) for the adolescents in the BD vs. control groups, and we used the Schedule for Affective Disorders and Schizophrenia for School-age Children – present and lifetime version (K-SADS-PL). We used the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version for each parent of adolescents in the BD and control groups to rule out psychopathologies. Results Attachment styles of participants were assessed according to A-RSQ, dismissing attachment style scores of adolescents in BD group were found significantly higher compared to the healthy control group (p<0.05). As a result of the assessments, 12 adolescents (48%) out of 25 in the BD group and 5 adolescents (18%) out of 28 in the control group were given DSM-IV Axis I diagnosis, which is a statistically significant result (p<0.05). However, when psychiatric diagnoses were assessed separately, the difference was not statistically significant. Conclusions We found that the adolescent children of parents with BD have increased risk of developing mental illnesses, and that these adolescents adopt dismissing attachment styles. PMID:25877235

78 FR 66865 - Negotiated Rulemaking Committee, Notice of Change to Schedule of Committee Meetings-Title IV...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

...On June 12, 2013, we announced our intention to establish a negotiated rulemaking committee to prepare proposed regulations to establish standards for programs that prepare students for gainful employment in a recognized occupation. We also announced the schedule for committee meetings. Because of the Federal Government shutdown due to a lapse in appropriations, we are rescheduling the second session of committee meetings to November 18-20, 2013. In addition, the last day of the second session will end at 5:00 p.m. instead of at noon.

Docetaxel in combination with epirubicin in metastatic breast cancer: pharmacokinetic interactions.

PubMed

Ceruti, M; Tagini, V; Recalenda, V; Arpicco, S; Cattel, L; Airoldi, M; Bumma, C

1999-01-01

Epirubicin (75 mg/m2) and docetaxel (75 mg/m2) were administered to 16 patients affected by metastatic breast cancer following two different schedules: (1) docetaxel as infusion administered 1 h after epirubicin administration (schedule A); and (2) docetaxel as infusion immediately (10 min) after the end of epirubicin i.v. bolus administration (schedule B). Experimental non-compartmental analyses such as AUC and Css, were affected very little by the drug combination, irrespective of whether the administration of docetaxel was immediately after the epirubicin bolus (10 min) or delayed (1 h). However, serum levels showed evidence of transient drug interaction: in schedule A, docetaxel infusion was associated with a transient increase of plasma epirubicin in correspondence with Cssmax of docetaxel. Bi-compartmental analysis showed a significant difference in epirubicin clearance between protocols A and B. It is suggested that polysorbate 80, used in minimal amounts to formulate docetaxel, may interfere with epirubicin plasma level.

Carisoprodol: update on abuse potential and legal status.

PubMed

Reeves, Roy R; Burke, Randy S; Kose, Samet

2012-11-01

Carisoprodol is a centrally acting skeletal muscle relaxant of which meprobamate, a controlled substance, is the primary active metabolite. The abuse of carisoprodol has increased dramatically in the last several years. A withdrawal syndrome occurs in some patients who abruptly cease carisoprodol intake. The symptoms of this syndrome are similar to those seen with meprobamate withdrawal, suggesting that they may result from withdrawal from meprobamate accumulated with intake of excessive carisoprodol; however, carisoprodol is capable of modulating GABAA function, which may contribute to its abuse potential.There has been considerable debate about whether carisoprodol should be considered a controlled substance. Carisoprodol was removed from the market in Norway on May 1, 2008, but may still be used by specially approved patients. Carisoprodol was classified as a controlled substance in several US states, and effective January 11, 2012, became a schedule IV controlled substance at the US federal level. This article updates the literature on abuse potential and examines recent developments regarding the legal status of carisoprodol.

Space X-3 Social Media Tour of KSC Facilities

NASA Image and Video Library

2014-03-14

CAPE CANAVERAL, Fla. – A group of news media and social media tweeters toured the Launch Abort System Facility and viewed the launch abort system for the Orion spacecraft at NASA's Kennedy Space Center in Florida. Speaking to the group is Scott Wilson, manager of Production Operations for the Orion Program. The group also toured the Launch Control Center and Vehicle Assembly Building, legacy facilities that are being upgraded by the Ground Systems Development and Operations Program at Kennedy to prepare for processing and launch of NASA's Space Launch System and Orion spacecraft. NASA is developing the Space Launch System and Orion spacecraft to provide an entirely new capability for human exploration beyond low-Earth orbit, with the flexibility to launch spacecraft for crew and cargo missions, including to an asteroid and Mars. Orion’s first unpiloted test flight is scheduled to launch later this year atop a Delta IV rocket. A second uncrewed flight test is scheduled for fiscal year 2018 on the Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Cory Huston

KSC-2013-3796

NASA Image and Video Library

2013-09-27

CAPE CANAVERAL, Fla. – Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, technicians prepare to work on the launch abort system, or LAS, for the Orion Exploration Flight Test-1 mission. Horizontally stacked together are the components of the LAS, the launch abort motor, the attitude control motor, the jettison motor and the fairing. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The LAS is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-3795

NASA Image and Video Library

2013-09-27

CAPE CANAVERAL, Fla. – Inside the Launch Abort System Facility at NASA’s Kennedy Space Center in Florida, a technician works on the launch abort system, or LAS, for the Orion Exploration Flight Test-1 mission. Horizontally stacked together are the components of the LAS, the launch abort motor, the attitude control motor, the jettison motor and the fairing. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. The LAS is designed to safely pull the Orion crew module away from the launch vehicle in the event of an emergency on the launch pad or during the initial ascent of NASA’s Space Launch System, or SLS, rocket. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on the SLS rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Radiation-induced Liver Injury after 3D-conformal Radiotherapy for Hepatocellular Carcinoma: Quantitative Assessment Using Gd-EOB-DTPA-enhanced MRI.

PubMed

Fukugawa, Yoshiyuki; Namimoto, Tomohiro; Toya, Ryo; Saito, Tetsuo; Yuki, Hideaki; Matsuyama, Tomohiko; Ikeda, Osamu; Yamashita, Yasuyuki; Oya, Natsuo

2017-02-01

Focal liver reaction (FLR) appears in the hepatobiliary-phase images of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) following radiotherapy (RT). We investigated the threshold dose (TD) for FLR development in 13 patients with hepatocellular carcinoma (HCC) who underwent three-dimensional conformal radiotherapy (3D-CRT) with 45 Gy in 15 fractions. FLR volumes (FLRVs) were calculated based on planning CT images by referring to fused hepatobiliary- phase images. We also calculated the TD and the irradiated volumes (IVs) of the liver parenchyma at a given dose of every 5 Gy (IVdose) based on a dose-volume histogram (DVH). The median TD was 35.2 Gy. The median IV20, IV25, IV30, IV35, IV40, and IV45 values were 371.1, 274.8, 233.4, 188.6, 145.8, and 31.0 ml, respectively. The median FLRV was 144.9 ml. There was a significant difference between the FLRV and IV20, IV25, and IV45 (p<0.05), but no significant differences between the FLRV and IV30, IV35, or IV40. These results suggest that the threshold dose of the FLR is approx. 35 Gy in HCC patients who undergo 3D-CRT in 15 fractions. The percentage of the whole liver volume receiving a dose of more than 30-40 Gy (V30-40) is a potential candidate optimal DVH parameter for this fractionation schedule.

Phase I study of 6-diazo-5-oxo-L-norleucine (DON).

PubMed

Sklaroff, R B; Casper, E S; Magill, G B; Young, C W

1980-01-01

We conducted a phase I study of 6-diazo-5-oxo-L-norleucine given iv on a twice weekly schedule. Twenty-six evaluable patients received 31 courses of the drug. Doses ranged from 100 to 500 mg/m2. Nausea with vomiting was the dose-limiting toxic effect, transient thrombocytopenia was seen frequently, and mucositis occurred in 39% of the patients. No definite therapeutic responses were observed in 18 patients with measurable lesions. The recommended dose for phase II studies is 200-300 mg/m2 iv twice weekly.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heinrichs, Dave; Beller, Tim; Burch, Jennifer

This document is the Final Design (CED-2) Report for IER-148, “International Inter-comparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV.” The report describes the structure of the exercise consisting of three irradiations; identifies the participating laboratories and their points of contact; provides the details of all dosimetry elements and their placement in proximity to Godiva-IV on support stands or phantoms ; and lists the counting and spectroscopy equipment each laboratory will utilize in the Mercury NAD Lab. The exercise is tentatively scheduled for one week in August 2015.

Prophylactic Use of Intravenous Clonidine Compared to Tramadol in Prevention of Intraoperative Shivering under Regional Anesthesia

PubMed Central

Guha (Banerjee), Sarmila; Nath, Pallab Kumar; Halder, Rita; Bandyopadhyay, Ujjwal

2017-01-01

Objectives: This study aimed to evaluate the relative efficacy of prophylactic intravenous (IV) clonidine and tramadol for control of intraoperative shivering following spinal anesthesia. Materials and Methods: After institutional ethical clearance, 142 patients were chosen from either gender, aged 20–60 years, physical status American Society of Anesthesiology Class I and II scheduled for elective infraumbilical surgery under spinal anesthesia. Patients were randomized into two groups: Group C (n = 71) received injection clonidine 50 μg) IV in 100 ml normal saline (NS) over 10 min and Group T (n = 71) received injection tramadol 50 mg IV. In 100 ml NS over 10 min after spinal anesthesia. Results: Incidence of shivering was not significant when compared between the two groups (P > 0.05). The axillary temperatures fell significantly in Group C from the baseline and remained at a significantly lower level up to 60 min after rescue drug was administered in patients who shivered. There was a similar fall in axillary temperature in Group T in patients having shivering, but the difference was not significant. When compared between the two groups among patients who shivered, the difference in fall of temperature was not significant. Side effects such as hypotension, bradycardia, and sedation were significantly more common in clonidine group, whereas nausea was significantly more common patients of tramadol group. Conclusion: Prophylactic administration of both tramadol and clonidine is effective for controlling shivering under spinal anesthesia. However, tramadol is better because of higher response rate, less sedation, and lesser hemodynamic alterations. PMID:28663645

Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study.

PubMed

Al-Qadheeb, Nada S; Skrobik, Yoanna; Schumaker, Greg; Pacheco, Manuel N; Roberts, Russel J; Ruthazer, Robin R; Devlin, John W

2016-03-01

To compare the efficacy and safety of scheduled low-dose haloperidol versus placebo for the prevention of delirium (Intensive Care Delirium Screening Checklist ≥ 4) administered to critically ill adults with subsyndromal delirium (Intensive Care Delirium Screening Checklist = 1-3). Randomized, double-blind, placebo-controlled trial. Three 10-bed ICUs (two medical and one surgical) at an academic medical center in the United States. Sixty-eight mechanically ventilated patients with subsyndromal delirium without complicating neurologic conditions, cardiac surgery, or requiring deep sedation. Patients were randomly assigned to receive IV haloperidol 1 mg or placebo every 6 hours until delirium occurred (Intensive Care Delirium Screening Checklist ≥ 4 with psychiatric confirmation), 10 days of therapy had elapsed, or ICU discharge. Baseline characteristics were similar between the haloperidol (n = 34) and placebo (n = 34) groups. A similar number of patients given haloperidol (12/34 [35%]) and placebo (8/34 [23%]) developed delirium (p = 0.29). Haloperidol use reduced the hours per study day spent agitated (Sedation Agitation Scale ≥ 5) (p = 0.008), but it did not influence the proportion of 12-hour ICU shifts patients spent alive without coma (Sedation Agitation Scale ≤ 2) or delirium (p = 0.36), the time to first delirium occurrence (p = 0.22), nor delirium duration (p = 0.26). Days of mechanical ventilation (p = 0.80), ICU mortality (p = 0.55), and ICU patient disposition (p = 0.22) were similar in the two groups. The proportion of patients who developed corrected QT-interval prolongation (p = 0.16), extrapyramidal symptoms (p = 0.31), excessive sedation (p = 0.31), or new-onset hypotension (p = 1.0) that resulted in study drug discontinuation was comparable between the two groups. Low-dose scheduled haloperidol, initiated early in the ICU stay, does not prevent delirium and has little therapeutic advantage in mechanically ventilated, critically ill adults with subsyndromal delirium.

Prenatal Alcohol Exposure Is Associated with Conduct Disorder in Adolescence: Findings from a Birth Cohort

PubMed Central

Larkby, Cynthia A.; Goldschmidt, Lidush; Hanusa, Barbara H.; Day, Nancy L.

2010-01-01

Objective To evaluate the association between prenatal alcohol exposure and the rate of Conduct Disorder in exposed compared to unexposed adolescents. Method Data for these analyses are from a longitudinal study of prenatal substance exposures. Women were interviewed at their 4th and 7th prenatal months, and with their children, at birth, 8 and 18 months, 3, 6, 10, 14, and 16 years postpartum. Offspring were interviewed with the Diagnostic Interview Schedule-IV; maternal and adolescent diagnoses were made using DSM-IV criteria at age 16. The sample was 592 adolescents and their mothers/caretakers. Results Prenatal alcohol exposure is significantly associated with an increased rate of Conduct Disorder in the adolescents. This effect was detected above an average exposure of 1 or more drinks/day in the first trimester. The effect remained significant after controlling for other significant variables including measures of the environment, maternal psychopathology, and other prenatal exposures. Conclusion Prenatal alcohol use in the first trimester is a risk factor for Conduct Disorder in the exposed offspring. PMID:21334566

Parker Solar Probe: Delta IV Heavy Second-stage and Port CBC Arrival, Offload, and Transport

NASA Image and Video Library

2017-08-26

The United Launch Alliance Mariner arrives at Port Canaveral's Army Warf carrying the third Delta IV Heavy common booster core and second stage for NASA's upcoming Parker Solar Probe spacecraft. The flight hardware is offloaded and transported to the Horizontal Integration Facility (HIF) at Cape Canaveral Air Force Station for preflight processing. The mission will perform the closest-ever observations of a star when it travels through the Sun's atmosphere, called the corona. The probe will rely on measurements and imaging to revolutionize our understanding of the corona and the Sun-Earth connection. Liftoff atop the Delta IV Heavy rocket is scheduled to take place from Cape Canaveral's Space Launch Complex 37 in summer 2018.

A Phase I study of intermittently dosed vorinostat in combination with bortezomib in patients with advanced solid tumors.

PubMed

Deming, Dustin A; Ninan, Jacob; Bailey, Howard H; Kolesar, Jill M; Eickhoff, Jens; Reid, Joel M; Ames, Matthew M; McGovern, Renee M; Alberti, Dona; Marnocha, Rebecca; Espinoza-Delgado, Igor; Wright, John; Wilding, George; Schelman, William R

2014-04-01

Accumulating evidence shows evidence of efficacy with the combination of vorinostat and bortezomib in solid tumors. We previously examined a once-daily continuous dosing schedule of vorinostat in combination with bortezomib which was well tolerated in cycles 1 and 2; however, there was concern regarding the tolerability through multiple cycles. This study was conducted to evaluate an intermittent dosing schedule of vorinostat with bortezomib. Vorinostat was initially administered orally twice daily on days 1-14 with bortezomib IV on days 1, 4, 8, and 11 of a 21 day cycle. Two DLTs (elevated ALT and fatigue) were observed at dose level 1, thus the protocol was amended to administer vorinostat intermittently twice daily on days 1-4 and 8-11. 29 patients were enrolled; 13 men and 16 women. Common cancer types included sarcoma, pancreatic, colorectal, GIST, and breast. The most common Grade 3-4 toxicities at any dose level included thrombocytopenia, fatigue, increased ALT, elevated INR, and diarrhea. DLTs in the intermittent dosing scheduled included thrombocytopenia and fatigue. The Cmax and AUC for the intermittent dosing regimen were similar to those observed in the daily dosing. In this heavily pretreated population, stable disease was observed in patients with sarcoma, colorectal adenocarcinoma and GIST. The MTD was established at vorinostat 300 mg BID on days 1-4 and 8-11 and bortezomib 1.3 mg/m(2) IV on days 1, 4, 8, and 11 of a 21 day cycle. Tolerability was not improved with the intermittent dosing schedule of vorinostat when compared to continuous dosing.

Trial by Fire

NASA Technical Reports Server (NTRS)

Covault, Craig

2005-01-01

Boeing is preparing a range of Delta IV Heavy launcher options for NASA Crew Exploration Vehicle (CEV) and unmanned cargo transportation architectures to the Moon and Mars, now that the massive new rocket has been flight tested. The December 21 launch of the 232-ft. vehicle on 2 million lb. thrust marked the largest all-liquid expendable booster flown since the last Saturn V in 1973. A second Delta IV Heavy mission is scheduled for this summer carrying a U.S. Air Force missile warning satellite. The first launch carried a dummy payload. Boeing wants NASA to consider the Delta IV Heavy for manned CEV missions, but is also pushing the Heavy for unmanned exploration launch roles. One Delta IV Medium version could also be a CEV player. Boeing says even modest upgrades could double the Delta Heavy's Earth orbit capability to more than 50 metric tons, including being able to fire up to 20 metric tons on escape trajectories to Mars.

Linear-parameter-varying gain-scheduled control of aerospace systems

NASA Astrophysics Data System (ADS)

Barker, Jeffrey Michael

The dynamics of many aerospace systems vary significantly as a function of flight condition. Robust control provides methods of guaranteeing performance and stability goals across flight conditions. In mu-syntthesis, changes to the dynamical system are primarily treated as uncertainty. This method has been successfully applied to many control problems, and here is applied to flutter control. More recently, two techniques for generating robust gain-scheduled controller have been developed. Linear fractional transformation (LFT) gain-scheduled control is an extension of mu-synthesis in which the plant and controller are explicit functions of parameters measurable in real-time. This LFT gain-scheduled control technique is applied to the Benchmark Active Control Technology (BACT) wing, and compared with mu-synthesis control. Linear parameter-varying (LPV) gain-scheduled control is an extension of Hinfinity control to parameter varying systems. LPV gain-scheduled control directly incorporates bounds on the rate of change of the scheduling parameters, and often reduces conservatism inherent in LFT gain-scheduled control. Gain-scheduled LPV control of the BACT wing compares very favorably with the LFT controller. Gain-scheduled LPV controllers are generated for the lateral-directional and longitudinal axes of the Innovative Control Effectors (ICE) aircraft and implemented in nonlinear simulations and real-time piloted nonlinear simulations. Cooper-Harper and pilot-induced oscillation ratings were obtained for an initial design, a reference aircraft and a redesign. Piloted simulation results for the initial LPV gain-scheduled control of the ICE aircraft are compared with results for a conventional fighter aircraft in discrete pitch and roll angle tracking tasks. The results for the redesigned controller are significantly better than both the previous LPV controller and the conventional aircraft.

40 CFR 52.2223 - Compliance schedules.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 1974: Submit to the Administrator a projection of the amount of fuel, by types, that will be... projected above. (iii) April 30, 1974: Submit a statement as to whether boiler modifications will be required. If modifications will be required, submit plans for such modifications. (iv) May 31, 1974: Let...

Psychiatric Comorbidity in Gender Dysphoric Adolescents

ERIC Educational Resources Information Center

de Vries, Annelou L. C.; Doreleijers, Theo A. H.; Steensma, Thomas D.; Cohen-Kettenis, Peggy T.

2011-01-01

Background: This study examined psychiatric comorbidity in adolescents with a gender identity disorder (GID). We focused on its relation to gender, type of GID diagnosis and eligibility for medical interventions (puberty suppression and cross-sex hormones). Methods: To ascertain DSM-IV diagnoses, the Diagnostic Interview Schedule for Children…

Computer Program (VEHSIM) For Vehicle Fuel Economy and Performance Simulation (Automobiles and Light Trucks) : Vol. IV: Enhancements

DOT National Transportation Integrated Search

1981-10-01

This report presents an updated description of a vehicle simulation program, VEHSIM, which can determine the fuel economy and performance of a specified vehicle over a defined route as it executes a given driving schedule. Vehicle input accommodated ...

(Docket A-93-02) Category IV-G: Post-Hearing Comments

EPA Pesticide Factsheets

This Index lists comments received after scheduled hearings related to the decision to certify that the Department of Energy had met the compliance criteria established by EPA in 40 CFR Part 194 and the disposal regulations set by EPA in 40 CFR Part 191.

KSC-11401f24

NASA Image and Video Library

1997-09-15

The Cassini spacecraft, covered by an environmentally controlled protective enclosure, is lifted at Launch Complex 40, Cape Canaveral Air Station (CCAS), in preparation to mate it to the top of its Titan IV/Centaur launch vehicle. Cassini is an international mission conducted by the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI). The two-story-tall spacecraft, scheduled for launch on Oct. 13, is destined to arrive at Saturn in July 2004, where it will orbit and study Saturn, its rings, moons and magnetic environment in detail over a four-year period. The Cassini mission is managed for NASA's Office of Space Science by the Jet Propulsion Laboratory, a division of the California Institute of Technology

46 CFR 109.301 - Operational readiness, maintenance, and inspection of lifesaving equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... and cleaning each fuel tank, and refilling it with fresh fuel. (2) Each davit, winch, fall and other...(e); (ii) Maintenance and repair instructions; (iii) A schedule of periodic maintenance; (iv) A... repair equipment. Spare parts and repair equipment must be provided for each lifesaving appliance and...

46 CFR 109.301 - Operational readiness, maintenance, and inspection of lifesaving equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and cleaning each fuel tank, and refilling it with fresh fuel. (2) Each davit, winch, fall and other...(e); (ii) Maintenance and repair instructions; (iii) A schedule of periodic maintenance; (iv) A... repair equipment. Spare parts and repair equipment must be provided for each lifesaving appliance and...

46 CFR 109.301 - Operational readiness, maintenance, and inspection of lifesaving equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... and cleaning each fuel tank, and refilling it with fresh fuel. (2) Each davit, winch, fall and other...(e); (ii) Maintenance and repair instructions; (iii) A schedule of periodic maintenance; (iv) A... repair equipment. Spare parts and repair equipment must be provided for each lifesaving appliance and...

46 CFR 109.301 - Operational readiness, maintenance, and inspection of lifesaving equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... and cleaning each fuel tank, and refilling it with fresh fuel. (2) Each davit, winch, fall and other...(e); (ii) Maintenance and repair instructions; (iii) A schedule of periodic maintenance; (iv) A... repair equipment. Spare parts and repair equipment must be provided for each lifesaving appliance and...

Evidence-Based Diagnosis: Incorporating Diagnostic Instruments into Clinical Practice

ERIC Educational Resources Information Center

Doss, Amanda Jensen

2005-01-01

This article is intended to serve as a practical guide for practitioners interested in incorporating evidence-based diagnosis (EBD) instruments into their clinical practices to refine the diagnostic process. Three measures are used to illustrate this process, the DISC-IV (Shaffer et al., 2000), the Schedule for Affective Disorders and…

49 CFR 1.44 - Reservation of authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... relating to safety fitness of an applicant (49 U.S.C. 1653(e)), the making of decisions on requests to... equivalent level: (i) Establishment or abolition of positions; (ii) Hires; (iii) Promotions other than quality and periodic within-grade promotions; (iv) Transfer of personnel to Schedule A, B, or C positions...

Altering Flight Schedules for Increased Fuel Efficiency

DTIC Science & Technology

2015-06-19

Committee Membership: Dr. Adam D. Reiman Chair (Primary Research Advisor) iv AFIT...vi Acknowledgments I would like to express my sincere appreciation to my faculty advisor, Lieutenant Colonel Adam Reiman , for his...18 Figure 11. Average Monthly Sea Level Temperature vs. Latitude ( Reiman , 2014) ....... 22 Figure 12. Charleston AFB Hourly Temperature

School Leadership Readiness: Traditional vs. Online Administrative Preparation

ERIC Educational Resources Information Center

Delfin, Jose

2012-01-01

According to the National Center of Educational Statistics (2006-2007) report, 92% of two and four-year Title IV degree-granting postsecondary institutions offered distance education courses due to students' demand for flexible scheduling. That same report cited that 82% of those institutions were seeking to increase student enrollment via…

Muscle and Liver Carbohydrates: Response to Military Task Performance by Women and Men

DTIC Science & Technology

1998-10-01

yes/ I noans. 4 no / 4 yes Food Allergies 7 no / 1 yes 8 no On a Diet 6 no/ 2 yes 7 no/ 1 yes Vegetarian 8 no 6 no /2 yes 42 APPENDIX IV: 2. EXERCISE...study (14 have completed at least 1 study, 3 are currently scheduled and are tracking diet & exercise, 2 are enrolled but not yet scheduled, 3 are in...subjects to pick up meals and follow their diet during the week prior to the study. This may be due to the distance that some of the subjects drive to

76 FR 2287 - Schedules of Controlled Substances: Temporary Placement of Five Synthetic Cannabinoids Into...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-13

...] Schedules of Controlled Substances: Temporary Placement of Five Synthetic Cannabinoids Into Schedule I... Notice of Intent announcing its intention to temporarily place five synthetic cannabinoids into Schedule... announced its intention to temporarily place five synthetic cannabinoids into schedule I of the Controlled...

Clinical outcome and cerebrospinal fluid profiles in patients with tick-borne encephalitis and prior vaccination history.

PubMed

Lenhard, Thorsten; Ott, Daniela; Jakob, Nurith J; Martinez-Torres, Francisco; Grond-Ginsbach, Caspar; Meyding-Lamadé, Uta

2018-05-01

Tick-borne encephalitis (TBE) is endemic in southern and eastern districts of Germany. Approximately 10-14% of the infected individuals suffer from long-term disability and in 1.5-3.6% the course is fatal. Two well-tolerated vaccines are available, which provide high protection and which have been confirmed in several field studies. Here we investigate clinical course, long-term outcome and cerebrospinal fluid (CSF) characteristics of TBE cases with a prior history of any vaccination as well as real vaccination breakthrough (VBT). A case series of 11 patients with a prior history of vaccination, part of a recently published lager cohort of 111 TBE cases. Evaluation included clinical data, degree of disability (modified RANKIN scale, mRS) and analysis of CSF and serum samples. Furthermore, metadata for extended analysis on clinical outcome of TBE with VBT were analysed. One patient had a clear VBT and ten of them had irregular vaccinations schedules (IVS). Infection severity did not differ in patients with IVS as compared to a non-vaccinated control cohort (median mRS: both 3.0) but these patients showed a stronger cellular immune response as measured by CSF pleocytosis (IVS, 205 cells/μL versus non-vaccinated control, 114 cell/μL, P < 0.05) and by differential pattern of CSF (intrathecal) immunoglobulin synthesis. However, shift analysis of VBT metadata using linear-by-linear association revealed a more serious course of TBE in patients with VBT than in a non-vaccinated control cohort (χ 2  = 9.95, P = 0.002). Furthermore, ordinal logistic regression analysis showed that VBT patients had an age-corrected, 2.65 fold (CI: 1.110-6.328; χ 2  = 4.813; p = 0.028) significant higher risk to suffer from moderate or severe infections, respectively. A history of IVS surprisingly seems to have no impact on the clinical course of TBE but may leave marks in the specific brain immune response. VBT patients, however, carry an age-independent, significant risk to experience a severe infection. Copyright © 2018 The Authors. Published by Elsevier GmbH.. All rights reserved.

Estimating the price elasticity of expenditure for prescription drugs in the presence of non-linear price schedules: an illustration from Quebec, Canada.

PubMed

Contoyannis, Paul; Hurley, Jeremiah; Grootendorst, Paul; Jeon, Sung-Hee; Tamblyn, Robyn

2005-09-01

The price elasticity of demand for prescription drugs is a crucial parameter of interest in designing pharmaceutical benefit plans. Estimating the elasticity using micro-data, however, is challenging because insurance coverage that includes deductibles, co-insurance provisions and maximum expenditure limits create a non-linear price schedule, making price endogenous (a function of drug consumption). In this paper we exploit an exogenous change in cost-sharing within the Quebec (Canada) public Pharmacare program to estimate the price elasticity of expenditure for drugs using IV methods. This approach corrects for the endogeneity of price and incorporates the concept of a 'rational' consumer who factors into consumption decisions the price they expect to face at the margin given their expected needs. The IV method is adapted from an approach developed in the public finance literature used to estimate income responses to changes in tax schedules. The instrument is based on the price an individual would face under the new cost-sharing policy if their consumption remained at the pre-policy level. Our preferred specification leads to expenditure elasticities that are in the low range of previous estimates (between -0.12 and -0.16). Naïve OLS estimates are between 1 and 4 times these magnitudes. (c) 2005 John Wiley & Sons, Ltd.

Protective specific immunity induced by doxorubicin plus TNF-alpha combination treatment of EL4 lymphoma-bearing C57BL/6 mice.

PubMed

Ehrke, M J; Verstovsek, S; Maccubbin, D L; Ujházy, P; Zaleskis, G; Berleth, E; Mihich, E

2000-07-01

The therapeutic efficacy of a single (day 8), moderate dose (4 mg/kg, i.v.) of doxorubicin (DOX, Adriamycin) combined with recombinant human TNF-alpha (3 different doses and 5 different schedules, i.v.) was evaluated in C57BL/6 mice bearing an implant (s.c.) of the DOX-sensitive, TNF-alpha-resistant EL4 lymphoma. In parallel to monitoring survival, the levels of several host anti-tumor cytolytic effector functions of splenocytes and thymocytes were evaluated throughout the treatment period and in long-term survivors (LTS). DOX treatment alone resulted in a moderate (approx. 20%) increase in life span but no cures. TNF-alpha alone, at any tested dose or schedule, had little or no positive effect on survival. The combinations of DOX and TNF-alpha were only slightly better than DOX alone with respect to the time to death of mice that died (approx. 29% increase); however, each of the combinations involving 1,000 U TNF-alpha/injection produced a fraction (20% to 80%) of LTS. The host defense activities examined included those of splenic and thymic cytolytic T lymphocytes (CTL) and lymphokine-activated killer cells as well as splenic tumoricidal macrophages. Although most activities were modulated by tumor growth and/or treatment, only CTL responsiveness appeared to correlate with survival. CTL activity in the treated groups with LTS was significantly higher than in control groups late in the treatment period. Finally, ex vivo analyses of splenocytes and thymocytes together with the rejection of implanted tumor at 17 months established that LTS displayed specific long-term immune memory. Copyright 2000 Wiley-Liss, Inc.

The utility of quantitative electroencephalography and Integrated Visual and Auditory Continuous Performance Test as auxiliary tools for the Attention Deficit Hyperactivity Disorder diagnosis.

PubMed

Kim, JunWon; Lee, YoungSik; Han, DougHyun; Min, KyungJoon; Kim, DoHyun; Lee, ChangWon

2015-03-01

This study investigated the clinical utility of quantitative electroencephalography (QEEG) and the Integrated Visual and Auditory Continuous Performance Test (IVA+CPT) as auxiliary tools for assessing Attention Deficit Hyperactivity Disorder (ADHD). All of 157 subjects were assessed using the Korean version of the Diagnostic Interview Schedule for Children Version IV (DISC-IV). We measured EGG absolute power in 21 channels and conducted IVA+CPT. We analyzed QEEG according to the Hz range: delta (1-4Hz), theta (4-8Hz), slow alpha (8-10Hz), fast alpha (10-13.5Hz), and beta (13.5-30Hz). To remove artifacts, independent component analysis was conducted (ICA), and the tester confirmed the results again. All of the IVA+CPT quotients showed significant differences between the ADHD and control groups. The ADHD group showed significantly increased delta and theta activity compared with the control group. The z-scores of theta were negatively correlated with the scores of IVA+CPT in ADHD combined type, and those of beta were positively correlated. IVA+CPT and QEEG significantly discriminated between ADHD and control groups. The commission error of IVA+CPT showed an accuracy of 82.1%, and the omission error of IVA+CPT showed an accuracy of 78.6%. The IVA+CPT and QEEG are expected to be valuable tools for aiding ADHD diagnosis accurately. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Perioperative Hydrocortisone Reduces Major Complications After Pancreaticoduodenectomy: A Randomized Controlled Trial.

PubMed

Laaninen, Matias; Sand, Juhani; Nordback, Isto; Vasama, Kaija; Laukkarinen, Johanna

2016-11-01

The aim of this study was to study whether post-pancreaticoduodenectomy complications (PPDC) in high-risk patients can be reduced with hydrocortisone. Soft pancreas is a well-known risk factor for PPDC. Previously, we have shown that patients with >40% acini in the pancreatic transection line are most prone to PPDC. Recent studies have demonstrated that surgical trauma leads to inflammation of the pancreatic remnant, which precedes PPDC. On the basis of power analysis, randomized controlled trial (RCT) (Clinicaltrials.gov NCT01460615), 155 patients (February 2011-May 2015) scheduled for pancreaticoduodenectomy were randomized to intravenous (i.v.) treatment with hydrocortisone 100 mg or placebo. All patients received the first dose at the induction of anesthesia. During the operation, the percentage of acini was calculated from pancreatic transection line frozen samples by a pathologist. As planned, only the high-risk patients with >40% acini (n = 62) continued in the study to receive in total 8 doses of randomization-based hydrocortisone/placebo every 8 hours. Primary endpoints were urine trypsinogen positive days and overall complications (Clavien-Dindo III-IV). Postoperative pancreatic fistulas (POPFs), postpancreatectomy hemorrhage (PPH), and delayed gastric emptying (DGE) were also graded. Hydrocortisone treatment did not alter trypsinogen release (2 or more positive days 46% vs 50%), but it significantly reduced overall complications compared with placebo in the high-risk patients (18% vs 41%; P < 0.05; Clavien-Dindo III-IV). Also, clinically significant POPF (11% vs 27%), PPH (14% vs 24%), and DGE (29% vs 44%) tended to be lower in the hydrocortisone group. Ninety-day mortality was zero. This RCT shows that in high-risk patients, overall PPDC can be significantly reduced with hydrocortisone treatment. Inflammation may be an important mediator of PPDC.

DSM-IV: a nosology sold before its time?

PubMed

Zimmerman, M; Jampala, V C; Sierles, F S; Taylor, M A

1991-04-01

The purpose of this study was to determine whether American psychiatrists believe that DSM-IV is being published too soon after DSM-III-R. The authors conducted a mail survey of the attitudes of practicing psychiatrists (N = 454), residency program directors (N = 128), residents (N = 1,331), and researchers (N = 196) toward the scheduled publication of DSM-IV in the early 1990s. They found that the majority of all four groups believed that DSM-IV is being published prematurely. In contrast to respondents who believed that the timing of DSM-IV is appropriate, those who indicated that it is being published too soon had more recently completed their residency training and also believed that DSM-III-R was published prematurely. There was no association between the psychiatrists' responses and their theoretical orientation, Board certification status, ownership of the DSM manuals, the length of time they had used DSM-III, and the diagnostic manual (DSM-III or DSM-III-R) they were currently using. The belief that DSM-IV is being published too soon could contribute to underuse of DSM-IV by substantial numbers of psychiatrists. Thus, to foster compliance with it, APA must preserve in its efforts to demonstrate that the advantages of publishing it in 1993 outweigh the disadvantages of adopting yet another manual.

New phenethylamines in Europe.

PubMed

King, L A

2014-01-01

Sixteen phenethylamines are now included in Schedules I and II of the United Nations 1971 Convention on Psychotropic Substances. Most of the ring-substituted compounds are in Schedule I, whereas 2C-B, amphetamine, and methamphetamine are listed in Schedule II. Substances in Schedule IV (e.g. benzphetamine) are now regarded as obsolete pharmaceutical products. They all represent the 'old phenethylamines'. By 2013, nearly 100 illicit phenethylamines had been found in the European Union (EU). Of these, nine (MBDB, 4-MTA, PMMA, 2C-I, 2C-T-2, 2C-T-7, TMA-2, 5-IT and 4-MA) were submitted for risk assessment by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). All except MBDB were recommended for EU-wide control. Of the 'new phenethylamines', 2C-B was the most commonly reported, but other 2C compounds were widespread. Many of the ring-substituted phenethylamines are described in the 1991 book PIHKAL. Many fused ring phenethylamines have appeared in the past few years; they include further benzofurans (e.g. 5-and 6-APB), indanylalkylamines (e.g. 5-IAP), dibenzofurans (e.g. 2C-B-FLY) and 2-aminopropylindoles (e.g.5-IT). The recent and rapid rise of phenethylamines with bulky N-substituents (e.g. 25I-NBOMe) has been particularly significant. Although not phenethylamines, it is notable that the thiophene bioisosteres of amphetamine and methamphetamine as well as certain conformationally-restricted variants (e.g. aminoindanes) have been found in recent drug seizures. In the United Kingdom Misuse of Drugs Act, most ring-substituted phenethylamines are either listed by name or are covered by generic definitions dating from 1977. In 2013, temporary generic legislation included a number of benzofurans, indanylalkylamines and certain 'NBOMe' compounds. Copyright © 2013 John Wiley & Sons, Ltd.

12 CFR Appendix A to Subpart B of... - Risk-Based Capital Stress Test

Code of Federal Regulations, 2010 CFR

2010-01-01

... Loan Number Ending Scheduled Balance Group Pre/Post Act Property State Product Type Origination Date... program assets post-1996 Act Swap balances; (iii) Farmer Mac I program assets pre-1996 Act; (iv) Farmer... stress test applies quarterly updates of the weighted average guarantee rates for post-1996 Farmer Mac I...

12 CFR Appendix A to Subpart B of... - Risk-Based Capital Stress Test

Code of Federal Regulations, 2011 CFR

2011-01-01

... Loan Number Ending Scheduled Balance Group Pre/Post Act Property State Product Type Origination Date... program assets post-1996 Act Swap balances; (iii) Farmer Mac I program assets pre-1996 Act; (iv) Farmer... stress test applies quarterly updates of the weighted average guarantee rates for post-1996 Farmer Mac I...

Establishing Ongoing, Early Identification Programs for Mental Health Problems in Our Schools: A Feasibility Study

ERIC Educational Resources Information Center

Nemeroff, Robin; Levitt, Jessica Mass; Faul, Lisa; Wonpat-Borja, Ahtoy; Bufferd, Sara; Setterberg, Stephen; Jensen, Peter S.

2008-01-01

The study evaluates the feasibility and effectiveness of several mental health screening and assessment tools in schools. A computerized version of the Diagnostic Interview Schedule for Children-IV proved to be feasible bridging the gap between mental health providers and unmet need of children accompanying risks.

38 CFR 4.125 - Diagnosis of mental disorders.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SCHEDULE FOR RATING DISABILITIES Disability Ratings Mental Disorders § 4.125 Diagnosis of mental disorders. (a) If the diagnosis of a mental disorder does not conform to DSM-IV or is not supported by the... substantiate the diagnosis. (b) If the diagnosis of a mental disorder is changed, the rating agency shall...

24 CFR 982.555 - Informal hearing for participant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... allowance schedule. (iii) A determination of the family unit size under the PHA subsidy standards. (iv) A... appropriate for the family unit size under the PHA subsidy standards, or the PHA determination to deny the... with HQS because of the family size. (8) A determination by the PHA to exercise or not to exercise any...

78 FR 39461 - Revision of Fee Schedules; Fee Recovery for Fiscal Year 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

... about the availability of information for this final rule. You may access information related to this... numbers are provided in a table in the section of this document entitled, ``Availability of Documents... Licensed by the NRC IV. Plain Writing V. Availability of Documents VI. Voluntary Consensus Standards VII...

5 CFR 536.306 - Limitation on retained rates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AND PAY RETENTION Pay Retention § 536.306 Limitation on retained rates. (a) A retained rate may not at any time exceed the rate payable for level IV of the Executive Schedule. (b) When an employee's... other law or regulation to the rate of basic pay the employee would have received but for this...

Caphosol(®) mouthwash gives no additional protection against oral mucositis compared to cryotherapy alone in stem cell transplantation. A pilot study.

PubMed

Svanberg, Anncarin; Öhrn, Kerstin; Birgegård, Gunnar

2015-02-01

To investigate if adding Caphosol(®), a mouthwash solution, to oral cryotherapy (OC) further protects against oral mucositis (OM), a toxic painful complication to high dose chemotherapy. The study was a randomised, controlled, study design. Patients ≥16 years scheduled for allogeneic stem cell transplantation were included consecutively and randomised to experimental group receiving OC combined with Caphosol(®) (n = 20) or control group receiving OC only (n = 20). OC was given from start to end of HDCT. Caphosol(®), from day 0 to day 21. There were no significant differences regarding age or gender between the groups. Mucositis was assessed with the World Health Organisation (WHO) grading scale. Pain was assessed with a 10 cm visual analogue scale (VAS) from 0 = no pain to 10 = worst imaginable pain. Start and duration of therapy with pain relieving drugs, serum C-reactive protein values, and number of days of hospitalisation were collected from the medical records. Data on OM, oral pain, use of i.v. opioids and total parenteral nutrition were collected during 22 days. There was no significant difference between the groups on OM, oral pain, use of i.v. opioids or TPN between the groups. The study showed no additional effect of combining Caphosol(®) with OC. Copyright © 2014 Elsevier Ltd. All rights reserved.

78 FR 21858 - Schedules of Controlled Substances: Temporary Placement of Three Synthetic Cannabinoids Into...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

...] Schedules of Controlled Substances: Temporary Placement of Three Synthetic Cannabinoids Into Schedule I... temporarily schedule three synthetic cannabinoids into the Controlled Substances Act (CSA) pursuant to the...). This action is based on a finding by the Deputy Administrator that the placement of these synthetic...

Implementation of the Provision of the Comprehensive Addiction and Recovery Act of 2016 Relating to the Dispensing of Narcotic Drugs for Opioid Use Disorder. Final rule.

PubMed

2018-01-23

The Comprehensive Addiction and Recovery Act (CARA) of 2016, which became law on July 22, 2016, amended the Controlled Substances Act (CSA) to expand the categories of practitioners who may, under certain conditions on a temporary basis, dispense a narcotic drug in Schedule III, IV, or V for the purpose of maintenance treatment or detoxification treatment. Separately, the Department of Health and Human Services, by final rule effective August 8, 2016, increased to 275 the maximum number of patients that a practitioner may treat for opioid use disorder without being separately registered under the CSA for that purpose. The Drug Enforcement Administration (DEA) is hereby amending its regulations to incorporate these statutory and regulatory changes.

Intravenous gestational nicotine exposure results in increased motivation for sucrose reward in adult rat offspring.

PubMed

Lacy, Ryan T; Hord, Lauren L; Morgan, Amanda J; Harrod, Steven B

2012-08-01

Prenatal tobacco smoke exposure is associated with alterations in motivated behavior in offspring, such as increased consumption of highly palatable foods and abused drugs. Animal models show that gestational nicotine (GN) exposure mediates changes in responding for sucrose and drug reward. A novel, intermittent low-dose intravenous (IV) exposure model was used to administer nicotine (0.05 mg/kg/injection) or saline 3×/day to rats on gestational days 8-21. Two experiments investigated the effect of IV GN on (1) the habituation of spontaneous locomotor activity and on (2) sucrose reinforced responding in offspring. For the operant experiments, animals acquired fixed-ratio (FR-3) responding for sucrose, 26% (w/v), and were tested on varying concentrations (0, 3, 10, 30, and 56%; Latin-square) according to a FR-3, and then a progressive-ratio (PR) schedule. Male and female adult offspring were used. IV GN did not alter birth or growth weight, or the number of pups born. No between-group differences in habituation to spontaneous locomotor activity were observed. FR testing produced an inverted U-shaped response curve, and rats showed peak responding for 10% sucrose reinforcement. Neither gestation nor sex affected responding, suggesting equivalent sensitivity to varying sucrose concentrations. PR testing revealed that GN rats showed greater motivation for sucrose reinforcement relative to controls. A low-dose, IV GN exposure model resulted in increased motivation to respond for sucrose reinforcement in adult offspring. This suggests that using a low number of cigarettes throughout pregnancy will result in increased motivation for highly palatable foods in adult, and perhaps, adolescent offspring. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Somatization as a predictor of suicidal ideation in dissociative disorders.

PubMed

Oztürk, Erdinç; Sar, Vedat

2008-12-01

This study was concerned with correlates of suicidal ideation among patients with chronic complex dissociative disorders. Participants were 40 patients diagnosed as having either dissociative identity disorder or dissociative disorder not otherwise specified according to the DSM-IV. The Dissociative Disorders Interview Schedule, the Dissociative Experiences Scale, the Somatoform Dissociation and the Childhood Trauma Questionnaires, the Spielberger Trait Anger Inventory, the Beck Suicidal Ideation Scale, and the Borderline Personality Disorder section of the Structured Clinical Interview for DSM-IV Personality Disorders were administered to all patients. Patients with suicidal ideas (n = 15) had concurrent somatization disorder more frequently than the remaining patients. Having significantly high scores on both trait and state dissociation measures, their dissociative disorder was more severe than that of the patients with no suicidal ideation. They had elevated scores for childhood emotional abuse, physical abuse and emotional neglect. Concurrent somatization disorder diagnosis was the only predictor of suicidal ideation when childhood trauma scores and borderline personality disorder diagnosis were controlled. Among dissociative patients, there is an association between somatization and suicidal ideation. A trauma-related insecure attachment pattern is considered as a common basis of this symptom cluster.

Rethinking the Clockwork of Work: Why Schedule Control May Pay Off at Work and at Home.

PubMed

Kelly, Erin L; Moen, Phyllis

2007-11-01

Many employees face work-life conflicts and time deficits that negatively affect their health, well-being, effectiveness on the job, and organizational commitment. Many organizations have adopted flexible work arrangements but not all of them increase schedule control, that is, employees' control over when, where, and how much they work. This article describes some limitations of flexible work policies, proposes a conceptual model of how schedule control impacts work-life conflicts, and describes specific ways to increase employees' schedule control, including best practices for implementing common flexible work policies and Best Buy's innovative approach to creating a culture of schedule control.

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner enters Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System

76 FR 58176 - Swap Transaction Compliance and Implementation Schedule: Trading Documentation and Margining...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

...)-(iii) is intended to work together with, and serve as a cross-reference to, rules proposed by the... Documentation proposal, proposed Sec. 23.504(b)(3)(iii) and (iv) are intended to work together with rules... require that SDs or MSPs work with their non-registrant counterparties to comply with these requirements...

10 CFR Appendix J to Part 50 - Primary Reactor Containment Leakage Testing for Water-Cooled Power Reactors

Code of Federal Regulations, 2014 CFR

2014-01-01

... air test pressure and to assure they will be subjected to the post accident differential pressure... Table of Contents I. Introduction. II. Explanation of terms. III. Leakage test requirements. A. Type A test. B. Type B test. C. Type C test. D. Periodic retest schedule. IV. Special test requirements. A...

10 CFR Appendix J to Part 50 - Primary Reactor Containment Leakage Testing for Water-Cooled Power Reactors

Code of Federal Regulations, 2012 CFR

2012-01-01

... air test pressure and to assure they will be subjected to the post accident differential pressure... Table of Contents I. Introduction. II. Explanation of terms. III. Leakage test requirements. A. Type A test. B. Type B test. C. Type C test. D. Periodic retest schedule. IV. Special test requirements. A...

10 CFR Appendix J to Part 50 - Primary Reactor Containment Leakage Testing for Water-Cooled Power Reactors

Code of Federal Regulations, 2010 CFR

2010-01-01

... air test pressure and to assure they will be subjected to the post accident differential pressure... Table of Contents I. Introduction. II. Explanation of terms. III. Leakage test requirements. A. Type A test. B. Type B test. C. Type C test. D. Periodic retest schedule. IV. Special test requirements. A...

10 CFR Appendix J to Part 50 - Primary Reactor Containment Leakage Testing for Water-Cooled Power Reactors

Code of Federal Regulations, 2013 CFR

2013-01-01

... air test pressure and to assure they will be subjected to the post accident differential pressure... Table of Contents I. Introduction. II. Explanation of terms. III. Leakage test requirements. A. Type A test. B. Type B test. C. Type C test. D. Periodic retest schedule. IV. Special test requirements. A...

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2013 CFR

2013-04-01

... limited to software, files, data, and prize schedules. (2) Downloads must use secure methodologies that... date of the completion of the download; (iii) The Class II gaming system components to which software was downloaded; (iv) The version(s) of download package and any software downloaded. Logging of the...

25 CFR 547.12 - What are the minimum technical standards for downloading on a Class II gaming system?

Code of Federal Regulations, 2014 CFR

2014-04-01

... limited to software, files, data, and prize schedules. (2) Downloads must use secure methodologies that... date of the completion of the download; (iii) The Class II gaming system components to which software was downloaded; (iv) The version(s) of download package and any software downloaded. Logging of the...

75 FR 68153 - To Adjust the Rules of Origin Under the United States-Bahrain Free Trade Agreement, Implement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-04

... Part IV The President Proclamation 8596--To Adjust the Rules of Origin Under the United States... Adjust the Rules of Origin Under the United States-Bahrain Free Trade Agreement, Implement Modifications... the HTS the schedule of duty reductions and rules of origin necessary or appropriate to carry out the...

21 CFR 1301.28 - Exemption from separate registration for practitioners dispensing or prescribing Schedule III, IV...

Code of Federal Regulations, 2010 CFR

2010-04-01

... practitioner will provide narcotic drugs or combinations of narcotic drugs for appropriate counseling and other... under § 1301.13. (ii) If the individual practitioner is a member of a group practice, the names of the other individual practitioners in the group and the DEA registration numbers issued to the other...

Advanced Clinical Decision Support for Transport of the Critically Ill Patient

DTIC Science & Technology

2012-10-01

status   epilepticus ...2013   Q2   2013   Q3   Status   1                   On  Schedule   1a...ii. status  asthmaticus,     iii. sedation  and  analgesia,     iv. mechanical  ventilator  management  for  children

76 FR 7607 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... places specified in Item IV below. The self-regulatory organization has prepared summaries, set forth in... its routing strategies, which were contained in its fee schedule, to the rule and to introduce additional routing strategies to the rule. Two of those strategies that the Exchange added to Rules 11.9(b)(3...

76 FR 78063 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-15

... Strategy Executions from the monthly Firm fee cap. The proposed change will be operative on December 1... those statements may be examined at the places specified in Item IV below. The Exchange has prepared... Change 1. Purpose The Exchange proposes to amend the Fee Schedule to exclude Strategy Executions from the...

76 FR 7608 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... places specified in Item IV below. The self-regulatory organization has prepared summaries, set forth in... 11.9 to add its routing strategies, which were contained in its fee schedule, to the rule and to introduce additional routing strategies to the rule. Two of those strategies that the Exchange added to...

5 CFR 530.304 - Establishing or increasing special rates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... otherwise payable to a category of employees in one or more areas or locations, grades or levels... made in one or more of the remaining rates of the affected grade or level. For any given grade, a.... A special rate may not exceed the rate for level IV of the Executive Schedule. (b) The circumstances...

19 CFR 162.45a - Summary forfeiture of Schedule I and Schedule II controlled substances.

Code of Federal Regulations, 2010 CFR

2010-04-01

... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE....S.C. 965. Accordingly, in the case of a seizure of Schedule I or Schedule II controlled substances...

Using Clinician-Rated Five-Factor Model Data to Score the DSM–IV Personality Disorders

PubMed Central

Miller, Joshua D.; Maples, Jessica; Few, Lauren R.; Morse, Jennifer Q.; Yaggi, Kirsten E.; Pilkonis, Paul A.

2013-01-01

Proposals suggest that many or all of the Diagnostic and Statistical Manual of Mental Disorders (4th ed. [DSM–IV]; American Psychiatric Association, 1994) personality disorders (PDs) may be omitted from the DSM (5th ed.; DSM–V ) and replaced with a dimensional trait model of personality pathology (Krueger, Skodol, Livesley, Shrout, & Huang, 2007; Skodol, 2009). Several authors have expressed concerns that this may be difficult for clinicians and researchers who are more comfortable with the extant PD diagnoses. In this study, we tested whether clinician ratings of traits from the Five-factor model (FFM; Costa & McCrae, 1990) can be used to recreate DSM–IV PDs. Using a sample of 130 clinical outpatients, we tested the convergent and discriminant validity of the FFM PD counts in relation to consensus ratings of the DSM–IV PDs. We then examined whether the FFM and DSM–IV PD scores correlate in similar ways with self-reported personality traits from the Schedule for Nonadaptive and Adaptive Personality (Clark, 1993). Finally, we tested the clinical utility of the FFM PD counts in relation to functional impairment. Overall, the FFM PD counts, scored using clinician ratings of the FFM traits, appeared to function like the DSM–IV PDs, thus suggesting that the use of a dimensional trait model of personality in the DSM–V may still allow for an assessment of the DSM–IV PD constructs. PMID:20552504

ADHD latent class clusters: DSM-IV subtypes and comorbidity

PubMed Central

Elia, Josephine; Arcos-Burgos, Mauricio; Bolton, Kelly L.; Ambrosini, Paul J.; Berrettini, Wade; Muenke, Maximilian

2014-01-01

ADHD (Attention Deficit Hyperactivity Disorder) has a complex, heterogeneous phenotype only partially captured by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. In this report, latent class analyses (LCA) are used to identify ADHD phenotypes using K-SADS-IVR (Schedule for Affective Disorders & Schizophrenia for School Age Children-IV-Revised) symptoms and symptom severity data from a clinical sample of 500 ADHD subjects, ages 6–18, participating in an ADHD genetic study. Results show that LCA identified six separate ADHD clusters, some corresponding to specific DSM-IV subtypes while others included several subtypes. DSM-IV comorbid anxiety and mood disorders were generally similar across all clusters, and subjects without comorbidity did not aggregate within any one cluster. Age and gender composition also varied. These results support findings from population-based LCA studies. The six clusters provide additional homogenous groups that can be used to define ADHD phenotypes in genetic association studies. The limited age ranges aggregating in the different clusters may prove to be a particular advantage in genetic studies where candidate gene expression may vary during developmental phases. DSM-IV comorbid mood and anxiety disorders also do not appear to increase cluster heterogeneity; however, longitudinal studies that cover period of risk are needed to support this finding. PMID:19900717

Rethinking the Clockwork of Work: Why Schedule Control May Pay Off at Work and at Home

PubMed Central

Kelly, Erin L.; Moen, Phyllis

2014-01-01

The problem and the solution Many employees face work–life conflicts and time deficits that negatively affect their health, well-being, effectiveness on the job, and organizational commitment. Many organizations have adopted flexible work arrangements but not all of them increase schedule control, that is, employees’ control over when, where, and how much they work. This article describes some limitations of flexible work policies, proposes a conceptual model of how schedule control impacts work–life conflicts, and describes specific ways to increase employees’ schedule control, including best practices for implementing common flexible work policies and Best Buy’s innovative approach to creating a culture of schedule control. PMID:25598711

Anodal transcranial direct current stimulation over the primary motor cortex does not enhance the learning benefits of self-controlled feedback schedules.

PubMed

Carter, Michael J; Smith, Victoria; Carlsen, Anthony N; Ste-Marie, Diane M

2018-05-01

A distinct learning advantage has been shown when participants control their knowledge of results (KR) scheduling during practice compared to when the same KR schedule is imposed on the learner without choice (i.e., yoked schedules). Although the learning advantages of self-controlled KR schedules are well-documented, the brain regions contributing to these advantages remain unknown. Identifying key brain regions would not only advance our theoretical understanding of the mechanisms underlying self-controlled learning advantages, but would also highlight regions that could be targeted in more applied settings to boost the already beneficial effects of self-controlled KR schedules. Here, we investigated whether applying anodal transcranial direct current stimulation (tDCS) to the primary motor cortex (M1) would enhance the typically found benefits of learning a novel motor skill with a self-controlled KR schedule. Participants practiced a spatiotemporal task in one of four groups using a factorial combination of KR schedule (self-controlled vs. yoked) and tDCS (anodal vs. sham). Testing occurred on two consecutive days with spatial and temporal accuracy measured on both days and learning was assessed using 24-h retention and transfer tests without KR. All groups improved their performance in practice and a significant effect for practicing with a self-controlled KR schedule compared to a yoked schedule was found for temporal accuracy in transfer, but a similar advantage was not evident in retention. There were no significant differences as a function of KR schedule or tDCS for spatial accuracy in retention or transfer. The lack of a significant tDCS effect suggests that M1 may not strongly contribute to self-controlled KR learning advantages; however, caution is advised with this interpretation as typical self-controlled learning benefits were not strongly replicated in the present experiment.

Effective treatment of laparoscopic cholecystectomy pain with intravenous followed by oral COX-2 specific inhibitor.

PubMed

Joshi, Girish P; Viscusi, Eugene R; Gan, Tong J; Minkowitz, Harold; Cippolle, Mark; Schuller, Rienhard; Cheung, Raymond Y; Fort, John G

2004-02-01

In this multicenter, double-blinded, randomized, placebo-controlled study we evaluated the analgesic and opioid-sparing efficacy of a preoperative dose of i.v. parecoxib followed by oral valdecoxib in treating pain associated with elective laparoscopic cholecystectomy. Patients were randomized to receive a single i.v. dose of parecoxib 40 mg (n = 134) or placebo (n = 129) 30-45 min before induction of anesthesia. Six to 12 h after the i.v. dose, the parecoxib group received a single oral dose of valdecoxib 40 mg, followed by valdecoxib 40 mg qd on postoperative days 1-4, then 40 mg qd prn days 5-7. The placebo i.v. group received oral placebo on an identical schedule. All patients were allowed supplemental i.v. fentanyl as needed during the first 4 h postoperatively (T0-240 min) followed by hydrocodone 5 mg/acetaminophen 500 mg (Vicodin(R); 1-2 tablets orally every 4-6 h as needed). Patients taking parecoxib used 21% less fentanyl than those receiving placebo (P = 0.011). The mean area under the curve of pain intensity (PI) scores over time from T0-240 min was 55.2 for parecoxib and 61.2 for placebo (P = 0.083). At T180 and T240 min, mean PI score was 7.0 and 7.6 points lower in the parecoxib group, respectively (P < 0.02). Fewer patients on valdecoxib required supplemental analgesics (P < 0.05) after discharge. At T240 min and at day 7, Patient's and Physician's/Nurse's Global Evaluations were significantly better in the parecoxib/valdecoxib group (P < 0.05). Incidences of adverse events, adverse events causing withdrawal, and serious adverse events were less for parecoxib/valdecoxib than for placebo. The authors conclude that preoperative parecoxib is a valuable opioid-sparing adjunct to the standard of care for treating pain after laparoscopic cholecystectomy, and subsequent treatment with oral valdecoxib extends this clinical benefit. Parecoxib 40 mg i.v., 30-45 min preoperatively followed by oral valdecoxib 40 mg qd reduced opioid requirements and provided superior pain relief as well as improved patient global evaluation after laparoscopic cholecystectomy.

KSC-2009-6786

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – In the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida, workers lower the second stage of a Delta IV rocket onto a transporter following the completion of nozzle extension deployment system testing in the hangar's test cell. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

KSC-2009-6779

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – Nozzle extension deployment system testing on the second stage of a Delta IV rocket has been completed in a test cell in the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

KSC-2009-6782

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – Workers move the second stage of a Delta IV rocket from a test cell in the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida into a turnover stand following the completion of nozzle extension deployment system testing. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

77 FR 63766 - Schedules of Controlled Substances: Placement of Methylone Into Schedule I

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

... DEPARTMENT OF JUSTICE Drug Enforcement Administration 21 CFR Part 1308 [Docket No. DEA-357] Schedules of Controlled Substances: Placement of Methylone Into Schedule I AGENCY: Drug Enforcement Administration, Department of Justice. ACTION: Notice of proposed rulemaking. SUMMARY: The Drug Enforcement...

Static-dynamic hybrid communication scheduling and control co-design for networked control systems.

PubMed

Wen, Shixi; Guo, Ge

2017-11-01

In this paper, the static-dynamic hybrid communication scheduling and control co-design is proposed for the networked control systems (NCSs) to solve the capacity limitation of the wireless communication network. The analytical most regular binary sequences (MRBSs) are used as the communication scheduling function for NCSs. When the communication conflicts yielded in the binary sequence MRBSs, a dynamic scheduling strategy is proposed to on-line reallocate the medium access status for each plant. Under such static-dynamic hybrid scheduling policy, plants in NCSs are described as the non-uniform sampled-control systems, whose controller have a group of controller gains and switch according to the sampling interval yielded by the binary sequence. A useful communication scheduling and control co-design framework is proposed for the NCSs to simultaneously decide the controller gains and the parameters used to generate the communication sequences MRBS. Numerical example and realistic example are respectively given to demonstrate the effectiveness of the proposed co-design method. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Job Design and Ethnic Differences in Working Women’s Physical Activity

PubMed Central

Grzywacz, Joseph G.; Crain, A. Lauren; Martinson, Brian C.; Quandt, Sara A.

2014-01-01

Objective To document the role job control and schedule control play in shaping women’s physical activity, and how it delineates educational and racial variability in associations of job and social control with physical activity. Methods Prospective data were obtained from a community-based sample of working women (N = 302). Validated instruments measured job control and schedule control. Steps per day were assessed using New Lifestyles 800 activity monitors. Results Greater job control predicted more steps per day, whereas greater schedule control predicted fewer steps. Small indirect associations between ethnicity and physical activity were observed among women with a trade school degree or less but not for women with a college degree. Conclusions Low job control created barriers to physical activity among working women with a trade school degree or less. Greater schedule control predicted less physical activity, suggesting women do not use time “created” by schedule flexibility for personal health enhancement. PMID:24034681

Job design and ethnic differences in working women's physical activity.

PubMed

Grzywacz, Joseph G; Crain, A Lauren; Martinson, Brian C; Quandt, Sara A

2014-01-01

To document the role job control and schedule control play in shaping women's physical activity, and how it delineates educational and racial variability in associations of job and social control with physical activity. Prospective data were obtained from a community-based sample of working women (N = 302). Validated instruments measured job control and schedule control. Steps per day were assessed using New Lifestyles 800 activity monitors. Greater job control predicted more steps per day, whereas greater schedule control predicted fewer steps. Small indirect associations between ethnicity and physical activity were observed among women with a trade school degree or less but not for women with a college degree. Low job control created barriers to physical activity among working women with a trade school degree or less. Greater schedule control predicted less physical activity, suggesting women do not use time "created" by schedule flexibility for personal health enhancement.

Application of precomputed control laws in a reconfigurable aircraft flight control system

NASA Technical Reports Server (NTRS)

Moerder, Daniel D.; Halyo, Nesim; Broussard, John R.; Caglayan, Alper K.

1989-01-01

A self-repairing flight control system concept in which the control law is reconfigured after actuator and/or control surface damage to preserve stability and pilot command tracking is described. A key feature of the controller is reconfigurable multivariable feedback. The feedback gains are designed off-line and scheduled as a function of the aircraft control impairment status so that reconfiguration is performed simply by updating the gain schedule after detection of an impairment. A novel aspect of the gain schedule design procedure is that the schedule is calculated using a linear quadratic optimization-based simultaneous stabilization algorithm in which the scheduled gain is constrained to stabilize a collection of plant models representing the aircraft in various control failure modes. A description and numerical evaluation of a controller design for a model of a statically unstable high-performance aircraft are given.

Cassini is moved to Pad 40, CCAS, and placed atop its Titan IV launcher

NASA Technical Reports Server (NTRS)

1997-01-01

The Cassini spacecraft is lowered to the top of its Titan IV/Centaur launch vehicle at Launch Complex 40, Cape Canaveral Air Station (CCAS). Cassini is an international mission conducted by the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI). The two-story-tall spacecraft, scheduled for launch on Oct. 6, is destined to arrive at Saturn in July 2004, where it will orbit and study Saturn, its rings, moons and magnetic environment in detail over a four-year period. The Cassini mission is managed for NASA's Office of Space Science by the Jet Propulsion Laboratory, a division of the California Institute of Technology.

Throttling Tor Bandwidth Parasites

DTIC Science & Technology

2011-09-23

this section, “ vanilla ” rep- resents unmodified Tor using a round-robin circuit scheduler and no throttling and can be used to compare results...and valid between 03:00:00 and 06:00:00. 7 0 5 10 15 20 Web Time to First Byte (s) 0.0 0.2 0.4 0.6 0.8 1.0 Cu m ul at iv e Fr ac tio n vanilla 5...KiBps 50 KiBps 300 KiBps (a) 0 5 10 15 20 25 30 Web Download Time (s) 0.0 0.2 0.4 0.6 0.8 1.0 Cu m ul at iv e Fr ac tio n vanilla 5 KiBps 50 KiBps 300

Orion Leaves from the VAB

NASA Image and Video Library

2014-11-11

At NASA's Kennedy Space Center in Florida, the agency's Orion is transported to Launch Complex 37 at Cape Canaveral Air Force Station. After arrival at the launch pad, United Launch Alliance engineers and technicians will lift Orion and mount it atop its Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Prevalence, Persistence, and Sociodemographic Correlates of DSM-IV Disorders in the National Comorbidity Survey Replication Adolescent Supplement

PubMed Central

Kessler, Ronald C.; Avenevoli, Shelli; Costello, E. Jane; Georgiades, Katholiki; Green, Jennifer Greif; Gruber, Michael J.; He, Jian-ping; Koretz, Doreen; McLaughlin, Katie A.; Petukhova, Maria; Sampson, Nancy A.; Zaslavsky, Alan M.; Merikangas, Kathleen Ries

2012-01-01

Context Community epidemiological data on the prevalence and correlates of adolescent mental disorders are needed for policy planning purposes. Only limited data of this sort are available. Objective To present estimates of 12-month and 30-day prevalence, persistence (12-month prevalence among lifetime cases and 30-day prevalence among 12-month cases), and sociodemographic correlates of commonly occurring DSM-IV disorders among adolescents in the National Comorbidity Survey Replication Adolescent Supplement. Design The National Comorbidity Survey Replication Adolescent Supplement is a US national survey of DSM-IV anxiety, mood, behavior, and substance disorders among US adolescents based on face-to-face interviews in the homes of respondents with supplemental parent questionnaires. Setting Dual-frame household and school samples of US adolescents. Participants A total of 10 148 adolescents aged 13 to 17 years (interviews) and 1 parent of each adolescent (questionnaires). Main Outcome Measures The DSM-IV disorders assessed with the World Health Organization Composite International Diagnostic Interview and validated with blinded clinical interviews based on the Schedule for Affective Disorders and Schizophrenia for School-Age Children. Good concordance (area under the receiver operating characteristic curve ≥0.80) was found between Composite International Diagnostic Interview and Schedule for Affective Disorders and Schizophrenia for School-Age Children diagnoses. Results The prevalence estimates of any DSM-IV disorder are 40.3% at 12 months (79.5% of lifetime cases) and 23.4% at 30 days (57.9% of 12-month cases). Anxiety disorders are the most common class of disorders, followed by behavior, mood, and substance disorders. Although relative disorder prevalence is quite stable over time, 30-day to 12-month prevalence ratios are higher for anxiety and behavior disorders than mood or substance disorders, suggesting that the former are more chronic than the latter. The 30-day to 12-month prevalence ratios are generally lower than the 12-month to lifetime ratios, suggesting that disorder persistence is due more to episode recurrence than to chronicity. Sociodemographic correlates are largely consistent with previous studies. Conclusions Among US adolescents, DSM-IV disorders are highly prevalent and persistent. Persistence is higher for adolescents than among adults and appears to be due more to recurrence than chronicity of childadolescent onset disorders. PMID:22147808

Evaluation of the Relationship between Brain-Derived Neurotropic Factor Levels and the Stroop Interference Effect in Children with Attention-Deficit Hyperactivity Disorder.

PubMed

Şimşek, Şeref; Gençoğlan, Salih; Yüksel, Tuğba; Kaplan, İbrahim; Aktaş, Hüseyin; Alaca, Rümeysa

2016-12-01

Brain-derived neurotropic factor (BDNF) has been suggested to play a role in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). In addition, impairment in executive functions has been reported in children with ADHD. This study investigated the presence of a relationship between Stroop test scores and BDNF levels in children with ADHD. The study was conducted in the Department of Child Psychiatry at Dicle University. The study included 49 children between 6 and 15 years of age (M/F: 42/7), who were diagnosed with ADHD according to DSM-IV, and who did not receive previous therapy. Similar in terms of age and gender to the ADHD group, 40 children were selected in the control group. The Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime version was administered to all participants. Parents and teachers were administered Turgay DSM-IV-based Child and Adolescent Behavior Disorders Screening and Rating Scale to measure symptom severity in children with ADHD. Children with ADHD underwent the Stroop test. BDNF levels were evaluated in serum by ELISA. The ADHD and control groups did not differ in terms of BDNF levels. BDNF levels did not differ between ADHD subtypes. There was also no relationship between the Stroop test interference scores and BDNF levels. The findings of the present study are in line with those in studies that demonstrated no significant role of BDNF in the pathogenesis of ADHD.

Association between altered lipid profiles and attention deficit hyperactivity disorder in boys.

PubMed

Avcil, Sibelnur

2018-04-24

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, which is multifactorial, complex, and seen most commonly in childhood. The aim of this study was to examine the hypothesis that altered serum lipid profiles are associated with ADHD. The study inluded 32 boys diagnosed with ADHD according to DSM-IV-R criteria and a control group of 29 healthy subjects. All patients were assessed with The Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version, the Turgay DSM-IV-based Disruptive Behavior Disorders Child and Adolescent Rating and Screening Scale, the Conners Parent Rating Scale-Revised Long Form, and the Conners Teacher Rating Scale. Measurements were taken of fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and 1-day food intake levels, and the groups were compared. The mean TC, LDL, and HDL levels were significantly lower in the ADHD group than the control group (p = .005, p < .001, p = .002, respectively). There was no significant difference between the groups' TG levels (p = .295). No significant differences were determined between the combined-type ADHD patients and the predominantly inattentive subtype of ADHD in respect to the lipid profile. The results of this study add to the growing body of evidence indicating an association between serum cholesterol and ADHD in boys. Further genetic and molecular studies are required to elucidate the biochemical mechanisms underlying this relationship.

An assessment of PERT as a technique for schedule planning and control

NASA Technical Reports Server (NTRS)

Sibbers, C. W.

1982-01-01

The PERT technique including the types of reports which can be computer generated using the NASA/LaRC PPARS System is described. An assessment is made of the effectiveness of PERT on various types of efforts as well as for specific purposes, namely, schedule planning, schedule analysis, schedule control, monitoring contractor schedule performance, and management reporting. This assessment is based primarily on the author's knowledge of the usage of PERT by NASA/LaRC personnel since the early 1960's. Both strengths and weaknesses of the technique for various applications are discussed. It is intended to serve as a reference guide for personnel performing project planning and control functions and technical personnel whose responsibilities either include schedule planning and control or require a general knowledge of the subject.

Scheduling and Delivering Aircraft to Departure Fixes in the NY Metroplex with Controller-Managed Spacing Tools

NASA Technical Reports Server (NTRS)

Chevalley, Eric; Parke, Bonny; Kraut, Josh M.; Bienert, Nancy; Omar, Faisal; Palmer, Everett A.

2015-01-01

In this paper, successful Time-Based Flow Management (TBFM) scheduling systems for arrivals are considered and adapted to apply to departures. We present a concept of operations that integrates Controller-Managed Spacing tools for departures (CMS-D) with existing tactical departure scheduling tools to coordinate demand at departure fixes in a metroplex environment. We tested our concept in a Human-in-the-Loop simulation and compared the effect of two scheduling conditions: 1) "Departure Scheduling" consisting of an emulation of the Integrated Departure and Arrival Capability (IDAC) where Towers and a Planner (Traffic Management Coordinator at the appropriate facility) coordinate aircraft scheduled takeoff times to departure fixes; and 2) "Arrival Sensitive Departure Scheduling" where, in addition, the Tower and Planner also consider arrival Scheduled Time of Arrivals (STAs) at the airport's dependent runway. Results indicate little difference between the two scheduling conditions, but a large difference between the No Tools and the two scheduling conditions with CMS-D tools. The scheduling/CMS-D tools conditions markedly reduced heading, speed clearances, and workload for controllers who were merging flows at the departure fixes. In the tool conditions, departure controllers conditioned departures earlier rather than later when aircraft were tied near the departure fixes. In the scheduling/CMS-D tools conditions, departures crossed the departure fixes 50 seconds earlier and with an 8% error rate (consisting of time ahead or behind desired time of arrival) compared to a 19% error rate in the No Tool condition. Two exploratory runs showed that similar beneficial effects can be obtained only with the CMS-D tools without scheduling takeoff times, but at the cost of a somewhat higher workload for controllers, indicating the benefits of pre-departure scheduling of aircraft with minimal delays. Hence, we found that CMS-D tools were very beneficial in the metroplex environment we tested but that further research is needed to clarify the benefits of the various scheduling approaches.

Expert system for on-board satellite scheduling and control

NASA Technical Reports Server (NTRS)

Barry, John M.; Sary, Charisse

1988-01-01

An Expert System is described which Rockwell Satellite and Space Electronics Division (S&SED) is developing to dynamically schedule the allocation of on-board satellite resources and activities. This expert system is the Satellite Controller. The resources to be scheduled include power, propellant and recording tape. The activities controlled include scheduling satellite functions such as sensor checkout and operation. The scheduling of these resources and activities is presently a labor intensive and time consuming ground operations task. Developing a schedule requires extensive knowledge of the system and subsystems operations, operational constraints, and satellite design and configuration. This scheduling process requires highly trained experts anywhere from several hours to several weeks to accomplish. The process is done through brute force, that is examining cryptic mnemonic data off line to interpret the health and status of the satellite. Then schedules are formulated either as the result of practical operator experience or heuristics - that is rules of thumb. Orbital operations must become more productive in the future to reduce life cycle costs and decrease dependence on ground control. This reduction is required to increase autonomy and survivability of future systems. The design of future satellites require that the scheduling function be transferred from ground to on board systems.

Good clinical activity and favorable toxicity profile of once weekly bortezomib, fotemustine, and dexamethasone (B-MuD) for the treatment of relapsed multiple myeloma.

PubMed

Mangiacavalli, Silvia; Pochintesta, Lara; Pascutto, Cristiana; Cocito, Federica; Pompa, Alessandra; Cazzola, Mario; Corso, Alessandro

2013-02-01

Since multiple myeloma (MM) is still not-curable, the management of relapse remains challenging. Given the known efficacy of alkylating agents in MM, we conducted a phase I/II study to test a new three drug combination in which Fotemustine (Muphoran), an alkylating agent of nitrosurea family, was added to bortezomib + dexamethasone backbone (B-MuD) for the treatment of MM relapsed patients. Fotemustine was administered at two dose levels (80-100 mg/m² i.v.) on day 1. The original 21-day schedule was early amended for extra-hematological toxicity and a 35-day schedule was adopted (Bortezomib 1.3 mg/m² i.v. on days 1, 8, 15, and 22, Dexamethasone 20 mg i.v. on days 1, 8, 15, and 22) for a total of six courses. Twenty-four patients were enrolled. The maximum tolerated dose of Fotemustine was 100 mg/m². The overall response rate was of 62% (CR 8%, VGPR 33%, and PR 21%). The median OS was 28.5 months, the median progression-free survival (PFS) was 19.1 months. B-MuD resulted effective in patients previous exposed to bortezomib without difference of response (P = 0.25) and PFS (P = 0.87) when compared to bortezomib-naive patients. Thrombocytopenia was the most common AE overall. In conclusion, B-MuD is an effective and well tolerated combination in relapsed MM patients even in advanced disease phase. Copyright © 2012 Wiley Periodicals, Inc.

Instructional versus schedule control of humans' choices in situations of diminishing returns

PubMed Central

Hackenberg, Timothy D.; Joker, Veronica R.

1994-01-01

Four adult humans chose repeatedly between a fixed-time schedule (of points later exchangeable for money) and a progressive-time schedule that began at 0 s and increased by a fixed number of seconds with each point delivered by that schedule. Each point delivered by the fixed-time schedule reset the requirements of the progressive-time schedule to its minimum value. Subjects were provided with instructions that specified a particular sequence of choices. Under the initial conditions, the instructions accurately specified the optimal choice sequence. Thus, control by instructions and optimal control by the programmed contingencies both supported the same performance. To distinguish the effects of instructions from schedule sensitivity, the correspondence between the instructed and optimal choice patterns was gradually altered across conditions by varying the step size of the progressive-time schedule while maintaining the same instructions. Step size was manipulated, typically in 1-s units, first in an ascending and then in a descending sequence of conditions. Instructions quickly established control in all 4 subjects but, by narrowing the range of choice patterns, they reduced subsequent sensitivity to schedule changes. Instructional control was maintained across the ascending sequence of progressive-time values for each subject, but eventually diminished, giving way to more schedule-appropriate patterns. The transition from instruction-appropriate to schedule-appropriate behavior was characterized by an increase in the variability of choice patterns and local increases in point density. On the descending sequence of progressive-time values, behavior appeared to be schedule sensitive, sometimes even optimally sensitive, but it did not always change systematically with the contingencies, suggesting the involvement of other factors. PMID:16812747

Can concomitant-boost accelerated radiotherapy be adopted as routine treatment for head-and-neck cancers? A 10-year single-institution experience.

PubMed

Allal, Abdelkarim S; Taussky, Daniel; Mach, Nicolas; Becker, Minerva; Bieri, Sabine; Dulguerov, Pavel

2004-04-01

Accelerated schedules are effective in overcoming repopulation during radiotherapy (RT) for head-and-neck cancers, but their feasibility is compromised by increased toxicity. The therapeutic ratio may be particularly favorable for 5-week regimens. This study reports the 10-year experience of a single institution in the routine use of concomitant boost RT as standard radical treatment in all but the most favorable stage patients. Between February 1991 and June 2001, 296 patients (mean age, 59 years) were treated with concomitant boost RT either alone (67%) or combined with cisplatin-based chemotherapy (33%), with a median tumor dose of 69.9 Gy. Tumors were located in the oropharynx in 52%, hypopharynx in 20%, larynx in 15%, nasopharynx in 7%, and oral cavity in 6%. International Union Against Cancer Stage III-IV disease represented 77% of tumors. The median follow-up for surviving patients was 55 months (range, 10-138 months). The RT schedule was completed to the prescribed dose in all but 1 patient. Twenty patients (7%) had a treatment interruption (median, 5 days; range, 2-35 days). Grade 3-4 Radiation Therapy Oncology Group acute toxicity was observed in 77% of patients, and nutritional support was required in 110 patients (37%). For all patients, the 5-year actuarial locoregional control and disease-free survival rate was 72% and 61%, respectively. In a multivariate analysis, only T and N stage was significantly associated with locoregional control and disease-free survival. Grade 3-4 late toxicity occurred in 14%, mostly bone and cartilage necrosis. The present, moderately accelerated, concomitant boost regimen is logistically feasible, causing minimal inconvenience to the technical staff and yielding a high rate of patient compliance. Concomitant chemotherapy administration is feasible provided that patients are carefully selected and supportive care is introduced in a timely fashion. Considering the manageable toxicity and the satisfactory tumor control obtained, this regimen represents a good choice when considering implementation of an altered RT fractionation schedule as standard treatment for head-and-neck cancers.

Cross-Layer Adaptive Feedback Scheduling of Wireless Control Systems

PubMed Central

Xia, Feng; Ma, Longhua; Peng, Chen; Sun, Youxian; Dong, Jinxiang

2008-01-01

There is a trend towards using wireless technologies in networked control systems. However, the adverse properties of the radio channels make it difficult to design and implement control systems in wireless environments. To attack the uncertainty in available communication resources in wireless control systems closed over WLAN, a cross-layer adaptive feedback scheduling (CLAFS) scheme is developed, which takes advantage of the co-design of control and wireless communications. By exploiting cross-layer design, CLAFS adjusts the sampling periods of control systems at the application layer based on information about deadline miss ratio and transmission rate from the physical layer. Within the framework of feedback scheduling, the control performance is maximized through controlling the deadline miss ratio. Key design parameters of the feedback scheduler are adapted to dynamic changes in the channel condition. An event-driven invocation mechanism for the feedback scheduler is also developed. Simulation results show that the proposed approach is efficient in dealing with channel capacity variations and noise interference, thus providing an enabling technology for control over WLAN. PMID:27879934

Prevalence Rates of Attention Deficit/Hyperactivity Disorder in a School Sample of Venezuelan Children

ERIC Educational Resources Information Center

Montiel, Cecilia; Pena, Joaquin A.; Montiel-Barbero, Isabel; Polanczyk, Guilherme

2008-01-01

A total of 1,535 4-12 year-old children were screened with the Conners' rating scales, followed by diagnostic confirmation by the diagnostic interview schedule for children-IV-parent version. The prevalence of ADHD was estimated to be 10.03%, and only 3.9% of children had received medication for the treatment of ADHD symptoms. Prevalence rates and…

Validity of the Children's Social Behavior Questionnaire (CSBQ) in Children with Intellectual Disability: Comparing the CSBQ with ADI-R, ADOS, and Clinical DSM-IV-TR Classification

ERIC Educational Resources Information Center

de Bildt, Annelies; Mulder, Erik J.; Hoekstra, Pieter J.; van Lang, Natasja D. J.; Minderaa, Ruud B.; Hartman, Catharina A.

2009-01-01

The Children's Social Behavior Questionnaire (CSBQ) was compared with the Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS), and clinical classification in children with mild and moderate intellectual disability (ID), to investigate its criterion related validity. The contribution of the CSBQ to a…

Comparing the Diagnostic Accuracy of Six Potential Screening Instruments for Bipolar Disorder in Youths Aged 5 to 17 Years.

ERIC Educational Resources Information Center

Youngstrom, Eric A.; Findling, Robert L.; Calabrese, Joseph R.; Gracious, Barbara L.; Demeter, Christine; DelPorto Bedoya, Denise; Price, Megan

2004-01-01

Objective: To compare the diagnostic efficiency of six index tests as predictors of juvenile bipolar disorder in two large outpatient samples, aged 5 to 10 and 11 to 17 years, gathered from 1997 to 2002. Method: DSM-IV diagnosis was based on a semistructured diagnostic interview (Schedule for Affective Disorders and Schizophrenia for School-Age…

78 FR 73143 - Negotiated Rulemaking Committee, Notice of Additional Committee Meeting-Title IV Federal Student...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-05

...On June 12, 2013, we announced our intention to establish a negotiated rulemaking committee to prepare proposed regulations to establish standards for programs that prepare students for gainful employment in a recognized occupation. We also announced the schedule for two sessions of committee meetings. We now announce the addition of a third session consisting of a one-day committee meeting.

A plant based protective antigen [PA(dIV)] vaccine expressed in chloroplasts demonstrates protective immunity in mice against anthrax.

PubMed

Gorantala, Jyotsna; Grover, Sonam; Goel, Divya; Rahi, Amit; Jayadev Magani, Sri Krishna; Chandra, Subhash; Bhatnagar, Rakesh

2011-06-15

The currently available anthrax vaccines are limited by being incompletely characterized, potentially reactogenic and have an expanded dosage schedule. Plant based vaccines offer safe alternative for vaccine production. In the present study, we expressed domain IV of Bacillus anthracis protective antigen gene [PA(dIV)] in planta (by nuclear agrobacterium and chloroplast transformation) and E. coli [rPA(dIV)]. The presence of transgene and the expression of PA(dIV) in planta was confirmed by molecular analysis. Expression levels up to 5.3% of total soluble protein (TSP) were obtained with AT rich (71.8% AT content) PA(dIV) gene in transplastomic plants while 0.8% of TSP was obtained in nuclear transformants. Further, we investigated the protective response of plant and E. coli derived PA(dIV) in mice by intraperitoneal (i.p.) and oral immunizations with or without adjuvant. Antibody titers of >10(4) were induced upon i.p. and oral immunizations with plant derived PA(dIV) and oral immunization with E. coli derived PA(dIV). Intraperitoneal injections with adjuvanted E. coli derived PA(dIV), generated highest antibody titers of >10(5). All the immunized groups demonstrated predominant IgG1 titers over IgG2a indicating a polarized Th2 type response. We also evaluated the mucosal antibody response in orally immunized groups. When fecal extracts were analyzed, low sIgA titer was demonstrated in adjuvanted plant and E. coli derived PA(dIV) groups. Further, PA(dIV) antisera enhanced B. anthracis spore uptake by macrophages in vitro and also demonstrated an anti-germinating effect suggesting a potent role at mucosal surfaces. The antibodies from various groups were efficient in neutralizing the lethal toxin in vitro. When mice were challenged with B. anthracis, mice immunized with adjuvanted plant PA(dIV) imparted 60% and 40% protection while E. coli derived PA(dIV) conferred 100% and 80% protection upon i.p. and oral immunizations. Thus, our study is the first attempt in highlighting the efficacy of plant expressed PA(dIV) by oral immunization in murine model. Copyright © 2011 Elsevier Ltd. All rights reserved.

The Feasibility of a Completely Automated Total IV Anesthesia Drug Delivery System for Cardiac Surgery.

PubMed

Zaouter, Cedrick; Hemmerling, Thomas M; Lanchon, Romain; Valoti, Emanuela; Remy, Alain; Leuillet, Sébastien; Ouattara, Alexandre

2016-10-01

In this pilot study, we tested a novel automatic anesthesia system for closed-loop administration of IV anesthesia drugs for cardiac surgical procedures with cardiopulmonary bypass. This anesthesia drug delivery robot integrates all 3 components of general anesthesia: hypnosis, analgesia, and muscle relaxation. Twenty patients scheduled for elective cardiac surgery with cardiopulmonary bypass were enrolled. Propofol, remifentanil, and rocuronium were administered using closed-loop feedback control. The main objective was the feasibility of closed-loop anesthesia defined as successful automated cardiac anesthesia without manual override by the attending anesthesiologist. Secondary qualitative observations were clinical and controller performances. The clinical performance of hypnosis control was the efficacy to maintain a bispectral index (BIS) of 45. To evaluate the hypnosis performance, BIS values were stratified into 4 categories: "excellent," "good," "poor," and "inadequate" hypnosis control defined as BIS values within 10%, ranging from 11% to 20%, ranging from 21% to 30%, or >30% of the target value, respectively. The clinical performance of analgesia was the efficacy to maintain NociMap values close to 0. The analgesia performance was assessed classifying the NociMap values in 3 pain control groups: -33 to +33 representing excellent pain control, -34 to -66 and +34 to +66 representing good pain control, and -67 to -100 and +67 to +100 representing insufficient pain control. The controller performance was calculated using the Varvel parameters. Robotic anesthesia was successful in 16 patients, which is equivalent to 80% (97.5% confidence interval [CI], 53%-95%) of the patients undergoing cardiac surgery. Four patients were excluded from the final analysis because of technical problems with the automated anesthesia delivery system. The secondary qualitative observations revealed that the clinical performance of hypnosis allowed an excellent and good control during 70% (97.5% CI, 63%-76%) of maintenance time and an insufficient clinical performance of analgesia for only 3% (97.5% CI, 1%-6%) of maintenance time. The completely automated closed-loop system tested in this investigation could be used successfully and safely for cardiac surgery necessitating cardiopulmonary bypass. The results of the present trial showed satisfactory clinical performance of anesthesia control.

Impact of the DSM-5 attention-deficit/hyperactivity disorder age-of-onset criterion in the US adolescent population.

PubMed

Vande Voort, Jennifer L; He, Jian-Ping; Jameson, Nicole D; Merikangas, Kathleen R

2014-07-01

The present study aims to compare the prevalence and clinical correlates of DSM-IV versus DSM-5-defined attention-deficit/hyperactivity disorder (ADHD) and subtypes in a nationally representative sample of US youth based on the age-of-onset criterion. The sample includes 1,894 participants 12 to 15 years of age from cross-sectional National Health and Nutrition Examination Survey (NHANES) surveys conducted from 2001 to 2004. Data on DSM-IV and DSM-5 criteria for ADHD were derived from administration of the parental ADHD module of the National Institute of Mental Health (NIMH) Diagnostic Interview Schedule for Children, Version IV (DISC-IV). Extension of the age-of-onset criterion from 7 to 12 years led to an increase in the prevalence rate of ADHD from 7.38% (DSM-IV) to 10.84% (DSM-5). Youth with later age of onset did not differ from those with earlier age of onset in terms of severity and patterns of comorbidity. However, the group with later age of onset was more likely to be from lower income and ethnic minority families. The comparability of the clinical significance of the early and later age-of-onset groups supports the DSM-5 extension of the age-of-onset criterion in ADHD. Published by Elsevier Inc.

Prevalence and correlates of fire-setting in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

PubMed

Blanco, Carlos; Alegría, Analucía A; Petry, Nancy M; Grant, Jon E; Simpson, H Blair; Liu, Shang-Min; Grant, Bridget F; Hasin, Deborah S

2010-09-01

To estimate the prevalence, sociodemographic correlates, comorbidity, and rates of mental health service utilization of fire-setters in the general population. A face-to-face survey of more than 43,000 adults aged 18 years and older residing in households was conducted during the 2001-2002 period. Diagnoses of mood, anxiety, substance use disorders, and personality disorders were based on the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version (AUDADIS-IV). The prevalence of lifetime fire-setting in the US population was 1.13 (95% CI, 1.0-1.3). Being male, never married, and US-born and having a yearly income over $70,000 were risk factors for lifetime fire-setting, while being Asian or Hispanic and older than 30 years were protective factors for lifetime fire-setting. The strongest associations with fire-setting were with disorders often associated with deficits in impulse control, such as antisocial personality disorder (ASPD) (odds ratio [OR] = 21.8; CI, 6.6-28.5), drug dependence (OR = 7.6; 95% CI, 5.2-10.9), bipolar disorder (OR = 5.6; 95% CI, 4.0-7.9), and pathological gambling (OR = 4.8; 95% CI, 2.4-9.5). Associations between fire-setting and all antisocial behaviors were positive and significant. A lifetime history of fire-setting, even in the absence of an ASPD diagnosis, was strongly associated with substantial rates of Axis I comorbidity, a history of antisocial behavior, a family history of other antisocial behaviors, decreased functioning, and higher treatment-seeking rates. Our findings suggest that fire-setting may be better understood as a behavioral manifestation of a broader impaired control syndrome and part of the externalizing spectrum. Fire-setting and other antisocial behaviors tend to be strongly associated with each other and increase the risk of lifetime and current psychiatric disorders, even in the absence of a DSM-IV diagnosis of ASPD. © Copyright 2010 Physicians Postgraduate Press, Inc.

Comparison between analgesic effect of bupivacaine thoracic epidural and ketamine infusion plus wound infiltration with local anesthetics in open cholecystectomy.

PubMed

Megahed, Nagwa Ahmed Ebrahim; Ellakany, Mohamed; Elatter, Ahmed Mohammed Ibrahim; Moustafa Teima, Mohamed Ahmed Ali

2014-01-01

Neuraxial blocks result in sympathetic block, sensory analgesia and motor block. Continuous epidural anesthesia through a catheter offers several options for perioperative analgesia. Local anesthetic boluses or infusions can provide profound analgesia. Although the role of low-dose ketamine (<2 mg/kg intramuscular, <1 mg/kg intravenous [IV] or ≤ 20 μg/kg/min by IV infusion) in the treatment of post-operative pain is controversial, perioperative administration of a small dose of ketamine may be valuable to a multimodal analgesic regimen. A local anesthetic can be used for wound infiltration intra-operative to minimized the surgical pain. A prospective randomized study was performed in which 40 patients scheduled for elective open cholecystectomy under general anesthesia admitted to the Medical Research Institute were included and further subdivided into two groups, group A, received thoracic epidural catheter at T7-8, activation was done 20 min before induction of anesthesia with plain bupivacaine at a concentration of 0.25% at a volume of 1 ml/segment aiming to block sensory supply from T4-L2, then received continuous thoracic epidural infusion intra and postoperatively with plain bupivacaine at a concentration of 0.125% at a rate of 5 ml/h for 24 h, group B received 0.3 mg/kg bolus of ketamine at the time of induction then 0.1 mg/kg/h ketamine IV infusion during surgery followed by wound infiltration with 15 ml of plain bupivacaine 0.5% at the time of skin closure. Bupivacaine thoracic epidural analgesia had better control on heart rate and mean arterial blood pressure than ketamine infusion plus wound infiltration with local anesthetic in patients undergoing open cholecystectomy. Thoracic epidural analgesia had better control on hemodynamic changes intra-and postoperatively than ketamine infusion with local wound infiltration in open cholecystectomy.

Phase II Study Evaluating the Addition of Cetuximab to the Concurrent Delivery of Weekly Carboplatin, Paclitaxel, and Daily Radiotherapy for Patients With Locally Advanced Squamous Cell Carcinomas of the Head and Neck

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suntharalingam, Mohan, E-mail: msuntha@umm.edu; Kwok, Young; Goloubeva, Olga

Purpose: To report the mature data of a prospective Phase II trial designed to evaluate the efficacy of an epidermal growth factor receptor inhibitor cetuximab (CTX) added to the concurrent therapy of weekly paclitaxel/carboplatin (PC) and daily radiation therapy (RT). Methods and Materials: From 2005 to 2009, a total of 43 patients were enrolled in the study. The median follow-up was 31 months (range, 9-59 months). All patients had Stage III/IV disease at presentation, and 67% had oropharyngeal primaries. The weekly IV dose schedules were CTX 250 mg/m{sup 2} (400 mg/m{sup 2} IV loading dose 1 week before RT), paclitaxelmore » 40 mg/m{sup 2}, and carboplatin AUC 2. RT was given at 1.8 Gy per day to 70.2 Gy. Intensity-modulated RTwas used in 70% of cases. Results: All patients completed the planned RT dose, 74% without any treatment breaks. The planned CTX and PC cycles were completed in 70% (91% with at least seven of planned nine cycles) and 56% (93% with at least seven of planned eight cycles) of patients, respectively. Toxicity included Grade 3 mucositis (79%), rash (9%), leucopenia (19%), neutropenia (19%), and RT dermatitis (16%). The complete response (CR) rate at the completion of therapy was 84%. The estimated 3-year local regional control rate was 72%. Six patients with an initial CR subsequently experienced a local recurrence, 10 patients experienced distant progression. The median overall survival and disease-free survivals have not been reached. The 3-year actuarial overall survival and disease-free survival were 59% and 58%, respectively. Conclusions: The addition of CTX to weekly PC and daily RT was well tolerated and resulted in encouraging local control and survival rates.« less

Shift work, age, and performance : investigation of the 2-2-1 shift schedule used in air traffic control facilities. I., The sleep/wake cycle.

DOT National Transportation Integrated Search

1995-05-01

Air Traffic Control Specialists (ATCS) work rotating shift schedules for most of their careers. Specifically, many work a counterclockwise rotating shift schedule, called the 2-2-1, or some variation of the schedule. The 2-2-1 involves rotating from ...

75 FR 79296 - Schedules of Controlled Substances: Placement of 5-Methoxy-N,N-Dimethyltryptamine into Schedule I...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

...] Schedules of Controlled Substances: Placement of 5-Methoxy-N,N- Dimethyltryptamine into Schedule I of the... Administration (DEA) places the substance 5- methoxy-N,N-dimethyltryptamine (5-MeO-DMT), including its salts..., actual abuse, pattern of abuse, and the relative potential for abuse of 5-methoxy-N,N-dimethyltryptamine...

Energy-driven scheduling algorithm for nanosatellite energy harvesting maximization

NASA Astrophysics Data System (ADS)

Slongo, L. K.; Martínez, S. V.; Eiterer, B. V. B.; Pereira, T. G.; Bezerra, E. A.; Paiva, K. V.

2018-06-01

The number of tasks that a satellite may execute in orbit is strongly related to the amount of energy its Electrical Power System (EPS) is able to harvest and to store. The manner the stored energy is distributed within the satellite has also a great impact on the CubeSat's overall efficiency. Most CubeSat's EPS do not prioritize energy constraints in their formulation. Unlike that, this work proposes an innovative energy-driven scheduling algorithm based on energy harvesting maximization policy. The energy harvesting circuit is mathematically modeled and the solar panel I-V curves are presented for different temperature and irradiance levels. Considering the models and simulations, the scheduling algorithm is designed to keep solar panels working close to their maximum power point by triggering tasks in the appropriate form. Tasks execution affects battery voltage, which is coupled to the solar panels through a protection circuit. A software based Perturb and Observe strategy allows defining the tasks to be triggered. The scheduling algorithm is tested in FloripaSat, which is an 1U CubeSat. A test apparatus is proposed to emulate solar irradiance variation, considering the satellite movement around the Earth. Tests have been conducted to show that the scheduling algorithm improves the CubeSat energy harvesting capability by 4.48% in a three orbit experiment and up to 8.46% in a single orbit cycle in comparison with the CubeSat operating without the scheduling algorithm.

Schedules of controlled substances: placement of 5-methoxy-N,N-dimethyltryptamine into Schedule I of the Controlled Substances Act. Final rule.

PubMed

2010-12-20

With the issuance of this final rule, the Deputy Administrator of the Drug Enforcement Administration (DEA) places the substance 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), including its salts, isomers and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule I of the Controlled Substances Act (CSA). This action by the DEA Deputy Administrator is based on a scheduling recommendation from the Assistant Secretary for Health of the Department of Health and Human Services (DHHS) and a DEA review indicating that 5-MeO-DMT meets the criteria for placement in schedule I of the CSA. This final rule will impose the criminal sanctions and regulatory controls of schedule I substances under the CSA on the manufacture, distribution, dispensing, importation, exportation, and possession of 5-MeO-DMT.

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner enters Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner is secured to the dock in Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner prepares to dock in Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner approaches the mouth of Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner nears the dock in Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner glides past the jetties as it enters Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner travels through Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Delta Mariner arrival with EFT-1 Booster

NASA Image and Video Library

2014-03-03

CAPE CANAVERAL, Fla. – The United Launch Alliance barge Delta Mariner docks in Port Canaveral in Florida. The barge is carrying two of the booster stages for the Delta IV Heavy rocket slated for Orion's Exploration Flight Test-1, or EFT-1. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep-space return velocities. The first unpiloted test flight of Orion is scheduled to launch in September 2014 atop a Delta IV Heavy rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: NASA/Frankie Martin

Cassini is moved to Pad 40, CCAS, and placed atop its Titan IV launcher

NASA Technical Reports Server (NTRS)

1997-01-01

The Cassini spacecraft arrives at Complex 40, Cape Canaveral Air Station (CCAS), where it will be lifted to the top of its Titan IV/Centaur launch vehicle. Cassini is an international mission conducted by the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI). The two-story-tall spacecraft, scheduled for launch on Oct. 6, is destined to arrive at Saturn in July 2004, where it will orbit and study Saturn, its rings, moons and magnetic environment in detail over a four-year period. The Cassini mission is managed for NASA's Office of Space Science by the Jet Propulsion Laboratory, a division of the California Institute of Technology.

Orion is on Pad 37 Prior to Hoist & Mate

NASA Image and Video Library

2014-11-12

The Orion spacecraft and its transporter stand at the base of the service structure at Space Launch Complex 37. A crane inside the structure will lift Orion off its transporter to hoist it into place atop the Delta IV Heavy rocket that is already assembled at the pad. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014, atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

THE EFFECTS OF FIXED VERSUS ESCALATING REINFORCEMENT SCHEDULES ON SMOKING ABSTINENCE

PubMed Central

Romanowich, Paul; Lamb, R. J.

2015-01-01

Studies indicate that when abstinence is initiated, escalating reinforcement schedules maintain continuous abstinence longer than fixed reinforcement schedules. However, these studies were conducted for shorter durations than most clinical trials and also resulted in larger reinforcer value for escalating participants during the 1st week of the experiment. We tested whether escalating reinforcement schedules maintained abstinence longer than fixed reinforcement schedules in a 12-week clinical trial. Smokers (146) were randomized to an escalating reinforcement schedule, a fixed reinforcement schedule, or a control condition. Escalating reinforcement participants received $5.00 for their first breath carbon monoxide (CO) sample <3 ppm, with a $0.50 increase for each consecutive sample. Fixed reinforcement participants received $19.75 for each breath CO sample <3 ppm. Control participants received payments only for delivering a breath CO sample. Similar proportions of escalating and fixed reinforcement participants met the breath CO criterion at least once. Escalating reinforcement participants maintained criterion breath CO levels longer than fixed reinforcement and control participants. Similar to previous short-term studies, escalating reinforcement schedules maintained longer durations of abstinence than fixed reinforcement schedules during a clinical trial. PMID:25640764

77 FR 64032 - Schedules of Controlled Substances: Extension of Temporary Placement of Methylone Into Schedule I...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

... is possible, will remain in effect until April 20, 2013, or until rulemaking proceedings are... isomers is possible, into Schedule I of the Controlled Substances Act (CSA). The temporary scheduling of... to the public safety pursuant to 21 U.S.C. 811(h)(1). At the time the Final Order took effect...

Comparative safety of intravenous Ferumoxytol versus Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia: rationale and study design of a randomized double-blind study with a focus on acute hypersensitivity reactions.

PubMed

Adkinson, N Franklin; Strauss, William E; Bernard, Kristine; Kaper, Robert F; Macdougall, Iain C; Krop, Julie S

2017-01-01

Intravenous (IV) iron is often used to treat iron deficiency anemia in patients who are unable to tolerate or are inadequately managed with oral iron. However, IV iron treatment has been associated with acute hypersensitivity reactions. The comparative risk of adverse events (AEs) with IV iron preparations has been assessed by a few randomized controlled trials, which are most often limited by small patient numbers, which lack statistical power to identify differences in low-frequency AE such as hypersensitivity reactions. Ferumoxytol versus Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia (FIRM) is a randomized, double-blind, international, multicenter, Phase III study designed to compare the safety of ferumoxytol and ferric carboxymaltose (FCM). The study includes adults with hemoglobin <12.0 g/dL (females) or <14.0 g/dL (males), transferrin saturation ≤20% or ferritin ≤100 ng/mL within 60 days of dosing, and a history of unsatisfactory or nontolerated oral iron therapy or in whom oral iron therapy is inappropriate. Patients are randomized (1:1) to ferumoxytol 510 mg or FCM 750 mg, each given intravenously on days 1 and 8. Primary end points are the incidence of moderate-to-severe hypersensitivity reactions, including anaphylaxis, and moderate-to-severe hypotension. All potential hypersensitivity and hypotensive reactions will be adjudicated by a blinded, independent Clinical Events Committee. A secondary safety end point is the composite frequency of moderate-to-severe hypersensitivity reactions, including anaphylaxis, serious cardiovascular events, and death. Secondary efficacy end points include mean change in hemoglobin and mean change in hemoglobin per milligram of iron administered from baseline to week 5. Urinary excretion of phosphorus and the occurrence of hypophosphatemia after IV iron administration will be examined as well as the mechanisms of such hypophosphatemia in a substudy. FIRM will provide data on the comparative safety of ferumoxytol and FCM, two IV iron preparations with similar dosing schedules, focusing on moderate-to-severe hypersensitivity reactions, including anaphylaxis, and moderate-to-severe hypotension. The study plans to enroll 2000 patients and is expected to complete in 2017.

Introducing iron isomaltoside 1000 (Monofer®)-development rationale and clinical experience.

PubMed

Kalra, Philip A

2011-06-01

Patients with chronic kidney disease (CKD) often suffer from iron deficiency anaemia necessitating treatment with intravenous (IV) iron. Several studies demonstrate that oral iron is insufficient in these patients and that IV supplementation is a more effective treatment. Until now, use of available parenteral iron preparations has been limited by dosing schedules and the need, in some cases, for a test dose, and despite the availability of a range of different IV iron compounds, there is still a need for improved compounds. The new IV iron, iron isomaltoside 1000 Monofer®, is composed of iron and chemically modified isomalto-oligosaccharides which have a mean molecular weight of 1000 Da and consist predominantly of 3-5 glucose units. In contrast to dextrans, the carbohydrate isomaltoside 1000 is a linear and unbranched structure with theoretically a low immunological potential. Hence, a test dose is not necessary. Iron isomaltoside 1000 contains strongly bound iron within the iron-isomaltoside formulation, which enables a controlled slow release of bioavailable iron to the iron-binding proteins, with potentially a reduced risk of free iron toxicity. This allows flexible dosing including high and rapid dosing securing convenient iron therapy for a wide range of patients. The development of Monofer® has been enthusiastically acknowledged by clinicians, and in 2009, there has been fast approval by European authorities via a decentralized registration procedure. This new IV iron is currently being marketed in several European countries. This article describes the development rationale and summarizes the clinical data assessing the use of iron isomaltoside 1000 administered without a test dose by either repeated bolus injections or fast high single iron infusions [defined as total dose infusion (TDI)] to patients suffering from CKD. Since CKD is associated with a high prevalence of cardiovascular disease, data from a small trial applying high single doses of iron isomatoside 1000 in patients with chronic heart failure (CHF) are also reviewed. Collectively, the available data demonstrate adequate efficacy and a good safety profile of iron isomaltoside 1000 in CKD and CHF patients even when administered without a test dose and as single rapid high-dose infusions.

Physical activity and alcohol use disorders.

PubMed

Lisha, Nadra E; Sussman, Steve; Fapa, Faahb; Leventhal, Adam M

2013-03-01

Prior research has documented a counterintuitive positive association between physical activity and indices of alcohol consumption frequency and heaviness. To investigate whether this relation extends to alcohol use disorder and clarify whether this association is non-linear. This is a cross-sectional, correlational population-based study of US adults (N = 34,653). The Alcohol Use Disorder and Associated Disabilities Interview Schedule was used to classify past-year DSM-IV alcohol use disorder and self-reported federal government-recommended weekly physical activity cutoffs. After statistically controlling for confounds, alcohol abuse but not dependence was associated with greater prevalence of physical activity. Number of alcohol use disorder symptoms exhibited a curvilinear relationship with meeting physical activity requirements, such that the positive association degraded with high symptom counts. There is a positive association between physical activity and less severe forms of alcohol use disorder in US adults. More severe forms of alcohol use disorder are not associated with physical activity.

Are personality disorders associated with social welfare burden in the United States?

PubMed

Vaughn, Michael G; Fu, Quana; Beaver, Devin; DeLisi, Matt; Perron, Brian; Howard, Matthew

2010-12-01

This study examined the association between personality disorders and use of major social welfare services in a nationally representative sample of U.S. adults (N = 43,093). Social welfare services received and diagnoses of personality, substance use, mood, and anxiety disorders were assessed with the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV-version. Analyses quantified the association between personality disorders and forms of public assistance while controlling for numerous confounds. Logistic regression analyses revealed dependent personality disorder, paranoid personality disorder, antisocial personality disorder, and avoidant personality disorder were significantly associated with increased odds of receiving public assistance. In contrast, persons diagnosed with histrionic, schizoid, and obsessive-personality disorder were not significantly more likely to receive any public welfare service. Development of effective prevention and treatment of personality disorders would likely lead to reductions in overall social welfare burden.

Contribution of Schedule Delays to Cost Growth: How to Make Peace with a Marching Army

NASA Technical Reports Server (NTRS)

Majerowicz, Walt; Bitten, Robert; Emmons, Debra; Shinn, Stephen A.

2016-01-01

Numerous research papers have shown that cost and schedule growth are interrelated for NASA space science missions. Although there has shown to be a strong correlation of cost growth with schedule growth, it is unclear what percentage of cost growth is caused by schedule growth and how schedule growth can be controlled. This paper attempts to quantify this percentage by looking at historical data and show detailed examples of how schedule growth influences cost growth. The paper also addresses a methodology to show an alternate approach for assessing and setting a robust baseline schedule and use schedule performance metrics to help assess if the project is performing to plan. Finally, recommendations are presented to help control schedule growth in order to minimize cost growth for NASA space science missions.

Is There a Downside to Schedule Control for the Work-Family Interface?

ERIC Educational Resources Information Center

Schieman, Scott; Young, Marisa

2010-01-01

Using data from a 2007 U.S. survey of workers, this article examines the implications of schedule control for work-family role blurring and work-family conflict. Four main findings indicate that (a) schedule control is associated with more frequent working at home and work-family multitasking activities; (b) the positive association between…

76 FR 30969 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... schedule II. The company plans to import Remifentanil in bulk for use in dosage- form manufacturing. Any... registration to import a basic class of any controlled substance in schedule I or II are, and will continue to... this Section to a bulk manufacturer of a controlled substance in schedule I or II, and prior to issuing...

KSC-2009-6784

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – In the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida, the second stage of a Delta IV rocket has been rotated to a horizontal position with the aid of a turnover stand following the completion of nozzle extension deployment system testing in the hangar's test cell. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

KSC-2009-6783

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – In the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida, workers rotate the second stage of a Delta IV rocket into a horizontal position with the aid of a turnover stand following the completion of nozzle extension deployment system testing in the hangar's test cell. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

KSC-2009-6785

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – In the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida, a worker secures the second stage of a Delta IV rocket to a device that will lift it from a turnover stand following the completion of nozzle extension deployment system testing in the hangar's test cell. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

KSC-2009-6780

NASA Image and Video Library

2009-12-11

CAPE CANAVERAL, Fla. – Workers prepare to lower the second stage of a Delta IV rocket from a test cell in the hangar of the Delta Operations Center at Cape Canaveral Air Force Station in Florida into a turnover stand following the completion of nozzle extension deployment system testing. The United Launch Alliance Delta IV rocket is slated to launch GOES-P, the latest Geostationary Operational Environmental Satellite developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Next, the second stage will be transported to the Horizontal Integration Facility where it will be inspected and prepared for mating with the Delta IV rocket's first stage. GOES-P, a meteorological satellite, is designed to watch for storm development and observed current weather conditions on Earth. Launch of GOES-P is scheduled for no earlier than Feb. 25, 2010, from Launch Complex 37. For information on GOES-P, visit http://goespoes.gsfc.nasa.gov/goes/spacecraft/n_p_spacecraft.html. Photo credit: NASA/Glenn Benson

Randomized trial comparing adriamycin vincristine (av) cyclophosphamide methotrexate 5-Fluorouracil prednisone (cmfp) hybrid versus av-cmfp monthly alternated in metastatic breast-cancer.

PubMed

Vallejo, C; Bianco, A; Perez, J; Machiavelli, M; Leone, B; Romero, A; Rabinovich, M; Alvarez, L; Rodriguez, R; Cuevas, M; Hannois, A; Lacava, J

1993-03-01

194 metastatic breast cancer patients with no prior chemotherapy for advanced disease were randomized to one of two alternating schedules, fulfilling the requisites of Goldie and Coldman's hypothesis to evaluate if the earlier alternation of two non-cross resistant regimens is superior in terms of response (R), duration of R (DR), and survival (SV). arm A: Adriamycin (A) 60 mg/m2 IV day (d) 1 and vincristine (V) 1.4 mg/m2 IV d 1 and 8 monthly alternated with cyclophosphamide (C) 100 mg/m2 p.o. d 1-14; methotrexate (M) 30 mg/m2 IV d 1 and 8; 5-fluorouracil (F) 600 mg/m2 IV d 1 and 8 and prednisone (Pr) 40 mg/m2 p.o. d 1-14. Arm B (hybrid): A 60 mg/m2 IV d 1; V 1.4 mg/m2 IV d 1; C 100 mg/m2 p.o. d 8-14; M 30 mg/m2 IV d 8; F 600 mg/m2 IV d 8 and Pr 40 mg/m2 p.o. d 8-14. 87 and 89 patients are evaluable for R. Arm A: R= 59% (51/87); median DR= 13 months (m); median SV= 25 m. Arm B: R= 69% (61/89); median DR= 15 m.; median SV= 29 m. Myelosuppression was slightly more marked in arm B. Three patients had toxic-related deaths (arm A: 1; arm B: 2). a trend favoring an earlier alternation and higher dose intensity (DI) was found regarding to R, DR and SV. However, differences were not statistically significant.

Effects of Lignocaine Administered Intravenously or Intratracheally on Airway and Hemodynamic Responses during Emergence and Extubation in Patients Undergoing Elective Craniotomies in Supine Position.

PubMed

Shabnum, Tabasum; Ali, Zulfiqar; Naqash, Imtiaz Ahmad; Mir, Aabid Hussain; Azhar, Khan; Zahoor, Syed Amer; Mir, Abdul Waheed

2017-01-01

Sympathoadrenergic responses during emergence and extubation can lead to an increase in heart rate (HR) and blood pressure whereas increased airway responses may lead to coughing and laryngospasm. The aim of our study was to compare the effects of lignocaine administered intravenously (IV) or intratracheally on airway and hemodynamic responses during emergence and extubation in patients undergoing elective craniotomies. Sixty patients with physical status American Society of Anaesthesiologists Classes I and II aged 18-70 years, scheduled to undergo elective craniotomies were included. The patients were randomly divided into three groups of twenty patients; Group 1 receiving IV lignocaine and intratracheal placebo (IV group), Group 2 receiving intratracheal lignocaine and IV placebo (I/T group), and Group 3 receiving IV and intratracheal placebo (placebo group). The tolerance to the endotracheal tube was monitored, and number of episodes of cough was recorded during emergence and at the time of extubation. Hemodynamic parameters such as HR and blood pressure (systolic, diastolic, mean arterial pressure) were also recorded. There was a decrease of HR in both IV and intratracheal groups in comparison with placebo group ( P < 0.005). Rise in blood pressure (systolic blood pressure, diastolic blood pressure and mean arterial pressure) was comparable in both Groups 1 and 2 but was lower in comparison with placebo group ( P < 0.005). Cough suppression was comparable in all the three groups. Grade III cough (15%) was documented only in placebo group. Both IV and intratracheal lignocaine are effective in attenuation of hemodynamic response if given within 20 min from skull pin removal to extubation. There was comparable cough suppression through intratracheal route and IV routes than the placebo group.

Tsukuba 32-m VLBI Station

NASA Technical Reports Server (NTRS)

Kawabata, Ryoji; Kurihara, Shinobu; Fukuzaki, Yoshihiro; Kuroda, Jiro; Tanabe, Tadashi; Mukai, Yasuko; Nishikawa, Takashi

2013-01-01

The Tsukuba 32-m VLBI station is operated by the Geospatial Information Authority of Japan. This report summarizes activities of the Tsukuba 32-m VLBI station in 2012. More than 200 sessions were observed with the Tsukuba 32-m and other GSI antennas in accordance with the IVS Master Schedule of 2012. We have started installing the observing facilities that will be fully compliant with VLBI2010 for the first time in Japan.

Phase I clinical and pharmacokinetic study of kahalalide F administered weekly as a 1-hour infusion to patients with advanced solid tumors.

PubMed

Pardo, Beatriz; Paz-Ares, Luis; Tabernero, Josep; Ciruelos, Eva; García, Margarita; Salazar, Ramón; López, Ana; Blanco, María; Nieto, Antonio; Jimeno, José; Izquierdo, Miguel Angel; Trigo, José Manuel

2008-02-15

A dose-escalation, phase I study evaluated the safety, pharmacokinetics, and efficacy of a weekly 1-h regimen of kahalalide F, a cyclic depsipeptide isolated from the marine mollusk Elysia rufescens, in adult patients with advanced solid tumors and no standard treatment available. Patients received an i.v. 1-h infusion of kahalalide F once weekly until disease progression or unacceptable toxicity. The starting kahalalide F dose was 266 microg/m(2), and dose escalation proceeded based on the worst toxicity found in the previous cohort. Thirty-eight patients were enrolled at three Spanish institutions and received once-weekly kahalalide F 1-h infusions at doses between 266 and 1,200 microg/m(2). Dose-limiting toxicities consisted of transient grade 3/4 increases in transaminase blood levels. The maximum tolerated dose for this kahalalide F schedule was 800 microg/m(2), and the recommended dose for phase II studies was 650 microg/m(2). No accumulated toxicity was found. One patient with malignant melanoma had unconfirmed partial response, one patient with metastatic lung adenocarcinoma had minor response, and six patients with different types of metastatic solid tumors had stable disease for 2.8 to 12.7 months. The noncompartmental pharmacokinetics of this kahalalide F schedule was linear and showed a narrow distribution and short body residence. The transaminitis associated with kahalalide F was dose dependent. The maximum tolerated dose was 800 microg/m(2). Dose-limiting toxicities with weekly kahalalide F 1-h i.v. infusions were transient grade 3/4 increases in blood transaminase levels, and 650 microg/m(2) was declared the recommended dose for phase II studies. This schedule showed a favorable safety profile and hints of antitumor activity.

LPV Controller Interpolation for Improved Gain-Scheduling Control Performance

NASA Technical Reports Server (NTRS)

Wu, Fen; Kim, SungWan

2002-01-01

In this paper, a new gain-scheduling control design approach is proposed by combining LPV (linear parameter-varying) control theory with interpolation techniques. The improvement of gain-scheduled controllers can be achieved from local synthesis of Lyapunov functions and continuous construction of a global Lyapunov function by interpolation. It has been shown that this combined LPV control design scheme is capable of improving closed-loop performance derived from local performance improvement. The gain of the LPV controller will also change continuously across parameter space. The advantages of the newly proposed LPV control is demonstrated through a detailed AMB controller design example.

Which resources moderate the effects of demanding work schedules on nurses working in residential elder care? A longitudinal study.

PubMed

Peters, Velibor; Houkes, Inge; de Rijk, Angelique E; Bohle, Philip L; Engels, Josephine A; Nijhuis, Frans J N

2016-06-01

Shiftwork is a major job demand for nurses and has been related to various negative consequences. Research suggests that personal and job resources moderate the impact of work schedules on stress, health and well-being. This longitudinal study examined whether the interactions of personal and job resources with work schedule demands predicted work engagement and emotional exhaustion in nursing. This longitudinal study included two waves of data collection with a one year follow-up using self-report questionnaires among 247 nurses working shifts or irregular working hours in residential care for the elderly in the Netherlands. Moderated structural equation modelling was conducted to examine the interactions between personal and job resources and work schedule demands. Two work schedule demands were assessed: type of work schedule (demanding vs. less demanding) and average weekly working hours. Two personal resources, active coping and healthy lifestyle, and two job resources, work schedule control and the work schedule fit with nurses' private life, were assessed. Results showed that the work schedule fit with nurses' private life buffered the relationship between work schedule demands and emotional exhaustion one year later. Furthermore, the work schedule fit with nurses' private life increased work engagement one year later when work schedule demands were high. Work schedule control strengthened the positive relationship between work schedule demands and emotional exhaustion one year later. The personal resources, active coping and healthy lifestyle were no moderators in this model. Nurses suffer less from decreasing work engagement and emotional exhaustion due to work schedule demands when their work schedules fit with their private lives. Work schedule control did not buffer, but strengthened the positive relationship between weekly working hours and emotional exhaustion one year later. Job resources appeared to be more important for nurses' well-being than personal resources. These findings highlight the importance of the fit of a work schedule with nurse's private life, if the work schedule is demanding. Copyright © 2016. Published by Elsevier Ltd.

Schedules of Controlled Substances: Extension of Temporary Placement of Three Synthetic Phenethylamines in Schedule I. Final order.

PubMed

2015-11-13

The Administrator of the Drug Enforcement Administration is issuing this final order extending the temporary schedule I status for three synthetic phenethylamines into the Controlled Substances Act pursuant to the temporary scheduling provisions of the Act. The substances are: 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36) [hereinafter 25I-NBOMe, 2C-NBOMe, and 25-NBOMe, respectively]. The initial temporary scheduling was based on a finding by the Deputy Administrator that the placement of these synthetic phenethylamines and their optical, positional, and geometric isomers, salts, and salts of isomers into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. The current final order temporarily placing 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe in schedule I is due to expire on November 14, 2015. This final order will extend the temporary scheduling of 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe for one year, or until the permanent scheduling action for these three substances is completed, whichever occurs first. As a result of this order, the full effect of the Controlled Substances Act and its implementing regulations, including criminal, civil and administrative penalties, sanctions, and regulatory controls of schedule I substances will be imposed on the manufacture, distribution, possession, importation, and exportation of these synthetic phenethylamines.

Deadlock-free genetic scheduling algorithm for automated manufacturing systems based on deadlock control policy.

PubMed

Xing, KeYi; Han, LiBin; Zhou, MengChu; Wang, Feng

2012-06-01

Deadlock-free control and scheduling are vital for optimizing the performance of automated manufacturing systems (AMSs) with shared resources and route flexibility. Based on the Petri net models of AMSs, this paper embeds the optimal deadlock avoidance policy into the genetic algorithm and develops a novel deadlock-free genetic scheduling algorithm for AMSs. A possible solution of the scheduling problem is coded as a chromosome representation that is a permutation with repetition of parts. By using the one-step look-ahead method in the optimal deadlock control policy, the feasibility of a chromosome is checked, and infeasible chromosomes are amended into feasible ones, which can be easily decoded into a feasible deadlock-free schedule. The chromosome representation and polynomial complexity of checking and amending procedures together support the cooperative aspect of genetic search for scheduling problems strongly.

Clinical features and psychiatric comorbidity of subjects with pathological gambling behavior.

PubMed

Black, D W; Moyer, T

1998-11-01

Sociodemographic features, phenomenology, and psychiatric comorbidity of 30 subjects reporting pathological gambling behavior were examined. Twenty-three men and seven women were recruited by advertisement and word-of-mouth. They all scored higher than 5 points on the South Oaks Gambling Screen, indicating problematic gambling behaviors. They completed structured and semistructured assessments, including the Diagnostic Interview Schedule for DSM-III-R disorders (DIS), the Personality Diagnostic Questionnaire, Fourth Revision (PDQ-IV), and the Minnesota Impulsive Disorders Interview. The typical subject was a 44-year-old white married man with a mean income of $34,250 who visited a casino once or more weekly. All 30 subjects reported gambling more money than they intended to. Twenty subjects (67 percent) reported gambling as a current problem, and nine (30 percent) reported it as a past problem. Twenty-one subjects (70 percent) wanted to stop gambling but did not feel they could. According to DIS results, 18 subjects (60 percent) had a lifetime mood disorder, 19 (64 percent) a lifetime substance use disorder, and 12 (40 percent) a lifetime anxiety disorder. Based on the PDQ-IV, 26 subjects (87 percent) had a personality disorder, the most common being obsessive-compulsive, avoidant, schizotypal, and paranoid personality disorders. The sample also had a relatively high rate of antisocial personality disorder. Impulse control disorders were common, especially compulsive buying and compulsive sexual behavior. The results confirm that individuals with pathological gambling suffer substantial psychiatric comorbidity. They support continued inclusion of pathological gambling in the diagnostic category of impulse control disorders.

Opioid use in knee arthroplasty after receiving intravenous acetaminophen.

PubMed

Kelly, Jennifer S; Opsha, Yekaterina; Costello, Jennifer; Schiller, Daryl; Hola, Eric T

2014-12-01

Intravenous (IV) acetaminophen may be an effective component of multimodal postoperative pain management. The primary objective of this study was to evaluate the impact of IV acetaminophen on total opioid use in postoperative patients. The secondary objective was to evaluate the effect of IV acetaminophen on hospital length of stay. This retrospective, case-control study evaluated the impact of IV acetaminophen on total opioid use in surgical patients. Patients were included if they received at least one perioperative dose of IV acetaminophen and underwent a surgical knee procedure. Controls were matched and randomly selected based on procedure type, age, and severity of illness. Postoperative opioids were converted into oral morphine equivalents, and overall use was compared between groups. One hundred patients were enrolled, with 25 patients receiving IV acetaminophen and 75 matched controls. A total of 135 mg versus 112.5 mg oral morphine equivalents were used in the IV acetaminophen group and control group, respectively (p=0.987). There were 45 mg/day oral morphine equivalents used in the IV acetaminophen group versus 37.5 mg in the control group (p=0.845). The median hospital length of stay in both groups was 3 days (p=0.799). IV acetaminophen did not significantly decrease postoperative opioid use in patients who underwent surgical knee procedures. In addition, there was a nonsignificant trend toward increased opioid use in the IV acetaminophen group. There was no significant difference in hospital length of stay between the IV acetaminophen group and the control group. These findings require further study in larger patient populations and in other orthopedic procedures that typically require longer hospital stays. © 2014 Pharmacotherapy Publications, Inc.

Integrated payload and mission planning, phase 3. Volume 4: Optimum utilization of Spacelab racks and pallets

NASA Technical Reports Server (NTRS)

Logston, R. G.; Budris, G. D.

1977-01-01

The methodology to optimize the utilization of Spacelab racks and pallets and to apply this methodology to the early STS Spacelab missions was developed. A review was made of Spacelab Program requirements and flow plans, generic flow plans for racks and pallets were examined, and the principal optimization criteria and methodology were established. Interactions between schedule, inventory, and key optimization factors; schedule and cost sensitivity to optional approaches; and the development of tradeoff methodology were addressed. This methodology was then applied to early spacelab missions (1980-1982). Rack and pallet requirements and duty cycles were defined, a utilization assessment was made, and several trade studies performed involving varying degrees of Level IV integration, inventory level, and shared versus dedicated Spacelab racks and pallets.

Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study.

PubMed

Bruintjes, Moira H D; Braat, Andries E; Dahan, Albert; Scheffer, Gert-Jan; Hilbrands, Luuk B; d'Ancona, Frank C H; Donders, Rogier A R T; van Laarhoven, Cornelis J H M; Warlé, Michiel C

2017-03-04

Postoperative recovery after live donor nephrectomy is largely determined by the consequences of postoperative pain and analgesia consumptions. The use of deep neuromuscular blockade has been shown to reduce postoperative pain scores after laparoscopic surgery. In this study, we will investigate whether deep neuromuscular blockade also improves the early quality of recovery after live donor nephrectomy. The RELAX-study is a phase IV, multicenter, double-blinded, randomized controlled trial, in which 96 patients, scheduled for living donor nephrectomy, will be randomized into two groups: one with deep and one with moderate neuromuscular blockade. Deep neuromuscular blockade is defined as a post-tetanic count of 1-2. Our primary outcome measurement will be the Quality of Recovery-40 questionnaire (overall score) at 24 h after extubation. This study is, to our knowledge, the first randomized study to assess the effectiveness of deep neuromuscular blockade during laparoscopic donor nephrectomy in enhancing postoperative recovery. The study findings may also be applicable for other laparoscopic procedures. clinicaltrials.gov, NCT02838134 . Registered on 29 June 2016.

Vehicle yaw stability control via H∞ gain scheduling

NASA Astrophysics Data System (ADS)

Zhang, Jinhua; Sun, Weichao; Feng, Zhiguang

2018-06-01

Yaw stability control (YSC) is rather significant in a vehicle lateral motion, since it can considerably reduce casualties caused by vehicle instability. Nevertheless with the vehicle running, the parameters, such as vehicle mass and moment of inertial, can be perturbed because of variation of capacity, loadage and consumption of fuel, hence some of nominal controllers cannot always work satisfactorily. To overcome the aforementioned deficiency, a gain scheduled H∞ YSC controller is developed in this paper, taking the vehicle mass and moment of inertial as the scheduled variables, now that the gain scheduled H∞ controller can guarantee both the robustness against parameter perturbation and the adjustability of tracking accuracy. Then the constructed controller is verified via numerical simulation and MATLAB-CarSim coalition simulation. The simulation results indicate that the designed controller can indeed improve the vehicle handing performance under circumstance of lateral stability.

Analysis and design of gain scheduled control systems. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Shamma, Jeff S.

1988-01-01

Gain scheduling, as an idea, is to construct a global feedback control system for a time varying and/or nonlinear plant from a collection of local time invariant designs. However in the absence of a sound analysis, these designs come with no guarantees on the robustness, performance, or even nominal stability of the overall gain schedule design. Such an analysis is presented for three types of gain scheduling situations: (1) a linear parameter varying plant scheduling on its exogenous parameters, (2) a nonlinear plant scheduling on a prescribed reference trajectory, and (3) a nonlinear plant scheduling on the current plant output. Conditions are given which guarantee that the stability, robustness, and performance properties of the fixed operating point designs carry over to the global gain scheduled designs, such as the scheduling variable should vary slowly and capture the plants nonlinearities. Finally, an alternate design framework is proposed which removes the slowing varying restriction or gain scheduled systems. This framework addresses some fundamental feedback issues previously ignored in standard gain.

Network Control Center User Planning System (NCC UPS)

NASA Astrophysics Data System (ADS)

Dealy, Brian

1991-09-01

NCC UPS is presented in the form of the viewgraphs. The following subject areas are covered: UPS overview; NCC UPS role; major NCC UPS functional requirements; interactive user access levels; UPS interfaces; interactive user subsystem; interface navigation; scheduling screen hierarchy; interactive scheduling input panels; autogenerated schedule request panel; schedule data tabular display panel; schedule data graphic display panel; graphic scheduling aid design; and schedule data graphic display.

Network Control Center User Planning System (NCC UPS)

NASA Technical Reports Server (NTRS)

Dealy, Brian

1991-01-01

NCC UPS is presented in the form of the viewgraphs. The following subject areas are covered: UPS overview; NCC UPS role; major NCC UPS functional requirements; interactive user access levels; UPS interfaces; interactive user subsystem; interface navigation; scheduling screen hierarchy; interactive scheduling input panels; autogenerated schedule request panel; schedule data tabular display panel; schedule data graphic display panel; graphic scheduling aid design; and schedule data graphic display.

Assessment of feasibility and efficacy of Class IV laser therapy for postoperative pain relief in off-pump coronary artery bypass surgery patients: A pilot study

PubMed Central

Karlekar, Anil; Bharati, Saswata; Saxena, Ravindra; Mehta, Kanchan

2015-01-01

Background: Laser therapy, for its established analgesic properties with minimal side effects, has been used for the treatment of chronic pain. However, it has not been used for the treatment of acute postoperative pain. This pilot study was designed to assess the feasibility and efficacy of Class IV laser on postoperative pain relief following off-pump coronary artery bypass graft (OPCABG) surgery, as a component of multimodal analgesia (MMA) technique. Methods: This open observational prospective study comprised of 100 adult patients (84 male, 16 female) who underwent OPCABG through sternotomy. For postoperative analgesia, they were subjected to laser therapy subjected to laser therapy in addition to the standard institutional pain management protocol comprising of IV infusion/bolus of tramadol and paracetamol and fentanyl bolus as rescue analgesic. Pain intensity was measured by Verbal Rating Scale (VRS). The laser therapy was scheduled as once a day regime for three consecutive postoperative days (PODs) starting on POD 1, 30 min following tracheal extubation. The subsequent laser applications were also scheduled at the same time of the day as on day 1 if VRS was ≥5. 10 W Class IV laser was applied over 150 cm2 sternal wound area for 150 s. VRS was used to assess pain severity and was recorded for statistical analysis using Friedman Test. Results: The mean (standard deviation [SD]) VRS of all the 100 patients just before application of the first dose of laser was 7.31 (0.94) while on MMT; the same fell to 4.0 (1.279) and 3.40 (2.697) at 1 h and 24 h respectively following first dose of laser. The change of VRS over first 24 h among all the 100 patients was statistically significant (P = 0.000). Laser was re-applied in 40 patients whose VRS was ≥5 (mean [SD] – 6.38 [0.868]) at 24th h. After receiving the 2nd dose of laser the VRS scores fell significantly (P = 0.000) and became 0 at 54th h. No patients required 3rd dose of the laser. No patient required rescue analgesic while on laser therapy. Conclusion: Class IV laser can be an effective technique for postoperative analgesia following OPCABG surgery through sternotomy when included as a component of MMA technique. PMID:26139735

Command in Air War: Centralized vs. Decentralized Control of Combat Airpower

DTIC Science & Technology

2005-05-19

centralized control of these missions, requiring a full day for scheduling a target, was ineffective at supporting the D-day invasion and even proved...dangerous to friendly troops. Americans developed a method of scheduling a steady stream of...controller took over this function. Thus, although the aircraft were still scheduled and routed by a centralized �Combined Operations Center,� they

Effects of chronic buspirone treatment on nicotine and concurrent nicotine+cocaine self-administration.

PubMed

Mello, Nancy K; Fivel, Peter A; Kohut, Stephen J

2013-06-01

Nicotine dependence and cocaine abuse are major public health problems, and most cocaine abusers also smoke cigarettes. An ideal pharmacotherapy would reduce both cigarette smoking and cocaine abuse. Buspirone (Buspar) is a clinically available, non-benzodiazepine anxiolytic medication that acts on serotonin and dopamine systems. In preclinical studies, it reduced cocaine self-administration following both acute and chronic treatment in rhesus monkeys. The present study evaluated the effectiveness of chronic buspirone treatment on self-administration of intravenous (IV) nicotine and IV nicotine+cocaine combinations. Five cocaine-experienced adult rhesus monkeys (Macaca mulatta) were trained to self-administer nicotine or nicotine+cocaine combinations, and food pellets (1 g) during four 1-h daily sessions under a second-order schedule of reinforcement (FR 2 (VR16:S)). Each nicotine+cocaine combination maintained significantly higher levels of drug self-administration than nicotine or cocaine alone (P<0.05-0.001). Buspirone (0.032-0.56 mg/kg/h) was administered IV through one lumen of a double-lumen catheter every 20 min for 23 h each day, for 7-10 consecutive days. Each 7-10-day sequence of buspirone treatment was followed by saline-control treatment for at least 3 days until food- and drug-maintained responding returned to baseline. Buspirone dose-dependently reduced responding maintained by nicotine alone (0.001-0.1 mg/kg/inj; P<0.01) and by nicotine (0.001 or 0.0032 mg/kg/inj)+cocaine combinations (0.0032 mg/kg/inj; P<0.05-0.001) with no significant effects on food-maintained responding. We conclude that buspirone selectively attenuates the reinforcing effects of nicotine alone and nicotine+cocaine polydrug combinations in a nonhuman primate model of drug self-administration.

Effects of Chronic Buspirone Treatment on Nicotine and Concurrent Nicotine+Cocaine Self-Administration

PubMed Central

Mello, Nancy K; Fivel, Peter A; Kohut, Stephen J

2013-01-01

Nicotine dependence and cocaine abuse are major public health problems, and most cocaine abusers also smoke cigarettes. An ideal pharmacotherapy would reduce both cigarette smoking and cocaine abuse. Buspirone (Buspar) is a clinically available, non-benzodiazepine anxiolytic medication that acts on serotonin and dopamine systems. In preclinical studies, it reduced cocaine self-administration following both acute and chronic treatment in rhesus monkeys. The present study evaluated the effectiveness of chronic buspirone treatment on self-administration of intravenous (IV) nicotine and IV nicotine+cocaine combinations. Five cocaine-experienced adult rhesus monkeys (Macaca mulatta) were trained to self-administer nicotine or nicotine+cocaine combinations, and food pellets (1 g) during four 1-h daily sessions under a second-order schedule of reinforcement (FR 2 (VR16:S)). Each nicotine+cocaine combination maintained significantly higher levels of drug self-administration than nicotine or cocaine alone (P<0.05–0.001). Buspirone (0.032–0.56 mg/kg/h) was administered IV through one lumen of a double-lumen catheter every 20 min for 23 h each day, for 7–10 consecutive days. Each 7–10-day sequence of buspirone treatment was followed by saline-control treatment for at least 3 days until food- and drug-maintained responding returned to baseline. Buspirone dose-dependently reduced responding maintained by nicotine alone (0.001–0.1 mg/kg/inj; P<0.01) and by nicotine (0.001 or 0.0032 mg/kg/inj)+cocaine combinations (0.0032 mg/kg/inj; P<0.05–0.001) with no significant effects on food-maintained responding. We conclude that buspirone selectively attenuates the reinforcing effects of nicotine alone and nicotine+cocaine polydrug combinations in a nonhuman primate model of drug self-administration. PMID:23337868

Cassini is moved to Pad 40, CCAS, and placed atop its Titan IV launcher

NASA Technical Reports Server (NTRS)

1997-01-01

Technicians at Launch Complex 40, Cape Canaveral Air Station (CCAS), connect the crane to the top of the Cassini spacecraft in preparation for the lift to the top of its Titan IV/Centaur launch vehicle. Cassini is an international mission conducted by the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI). The two-story-tall spacecraft, scheduled for launch on Oct. 6, is destined to arrive at Saturn in July 2004, where it will orbit and study Saturn, its rings, moons and magnetic environment in detail over a four-year period. The Cassini mission is managed for NASA's Office of Space Science by the Jet Propulsion Laboratory, a division of the California Institute of Technology.

Cassini is moved to Pad 40, CCAS, and placed atop its Titan IV launcher

NASA Technical Reports Server (NTRS)

1997-01-01

Technicians at Cape Canaveral Air Station (CCAS) begin to remove the transportation cover from the Cassini spacecraft after it was lifted to the top of the Titan IV/Centaur launch vehicle at Complex 40. Cassini is an international mission conducted by the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI). The two-story-tall spacecraft, scheduled for launch on Oct. 6, is destined to arrive at Saturn in July 2004, where it will orbit and study Saturn, its rings, moons and magnetic environment in detail over a four-year period. The Cassini mission is managed for NASA's Office of Space Science by the Jet Propulsion Laboratory, a division of the California Institute of Technology.

Orion Leaves from the VAB

NASA Image and Video Library

2014-11-11

At NASA's Kennedy Space Center in Florida, the agency's Orion spacecraft passes the spaceport's iconic Vehicle Assembly Building as it is transported to Launch Complex 37 at Cape Canaveral Air Force Station. After arrival at the launch pad, United Launch Alliance engineers and technicians will lift Orion and mount it atop its Delta IV Heavy rocket. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014 atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket.

Withdrawing from Iraq: Alternative Schedules, Associated Risks, and Mitigating Strategies

DTIC Science & Technology

2009-01-01

Reconstruction, 2009a. 22 Special Inspector General for Iraq Reconstruction, 2008 and 2009a. 23 Marsden, 2009; Watkins , 2008. 142 Withdrawing from Iraq...www.globalsecurity.org/military/world/iraq/mek.htm Bibliography 157 Gompert, David C., John Gordon IV, Adam Grissom, David R. Frelinger, Seth G. Jones...Michael, “Fighting Identity: Why We Are Losing Our Wars,” Military Review, November– December 2007, pp. 2–12. Watkins , Eric, “EA Report Outlines

Ny-Alesund Geodetic Observatory

NASA Technical Reports Server (NTRS)

Sieber, Moritz

2013-01-01

In 2012 the 20-m telescope at Ny-Alesund, Svalbard, operated by the Norwegian Mapping Authority (NMA), took part in 163 out of 168 scheduled sessions of the IVS program. Since spring, all data was transferred by network, and the receiver monitoring computer was replaced by a bus-coupler. In autumn, the NMA received building permission for a new observatory from the Governor of Svalbard. The bidding process and first construction work for the infrastructure will start in 2013.

49 CFR Appendix A to Part 238 - Schedule of Civil Penalties 1

Code of Federal Regulations, 2012 CFR

2012-10-01

... straight plate wheels 2,500 5,000 238.121Emergency communication 2,500 5,000 238.123Emergency roof access 2...) Wheel not in proper condition: (i), (iv) Flat spot(s) and shelled spot(s): (A) One spot 21/2″ or more... in flange, tread, rim, plate, or hub: (A) Crack of less than 1″ 2,500 5,000 (B) Crack of 1″ or more 5...

49 CFR Appendix A to Part 238 - Schedule of Civil Penalties 1

Code of Federal Regulations, 2011 CFR

2011-10-01

... straight plate wheels 2,500 5,000 238.121Emergency communication 2,500 5,000 238.123Emergency roof access 2...) Wheel not in proper condition: (i), (iv) Flat spot(s) and shelled spot(s): (A) One spot 21/2″ or more... in flange, tread, rim, plate, or hub: (A) Crack of less than 1″ 2,500 5,000 (B) Crack of 1″ or more 5...

33 CFR Schedule II to Subpart A of... - Table of Speeds 1

Code of Federal Regulations, 2012 CFR

2012-07-01

.... III Col. IV 1. Upper Entrance, South Shore Canal Lake St. Louis, Buoy A13 10.5 10.5. 2. Lake St. Louis.... Eisenhower Lock Iroquois Lock 11.5 10.5. 7. Iroquois Lock McNair Island, Lt. 137 13 10.5. 8. McNair Island, Lt. 137 Deer Island, Lt. 186 11.5 10.5. 9. Deer Island, Lt. 186 Bartlett Point, Lt. 227 8.5 upb; 10.5...

The Efficacy of Self-Report Measures in Predicting Social Phobia in African American Adults.

PubMed

Chapman, L Kevin; Petrie, Jenny M; Richards, Allyn

2015-03-01

Empirical literature pertaining to anxiety in African Americans has been relatively sparse. More recent studies indicate that the construct of social fear is different in African Americans than in non-Hispanic Whites. Although some of these studies have examined factor structure utilizing self-report measures of anxiety in African American samples, none to date have examined the clinical utility of these measures in predicting anxiety diagnoses, particularly social phobia. A total of sixty-five African American adults from the community completed the Fear Survey Schedule-Second Edition (FSS-II), Social Anxiety Interaction Scale (SIAS), Social Phobia Scale (SPS), and Albany Panic and Phobia Questionnaire (APPQ). The Anxiety Disorder Interview Schedule-Fourth Edition (ADIS-IV) was administered to all participants to specify differential diagnoses of anxiety and related disorders. Twenty-three African American adults were diagnosed with social phobia leaving 42 diagnostic controls. Results suggest that the social anxiety factors were highly predictive of a social phobia diagnosis (AUC=.84 to .90; CI .73-.98, p<.01) and sensitivity and specificity rates revealed optimal cutoff scores for each measure. The optimal cutoff scores reveal the clinical utility of the social fear factor from these measures in screening for social phobia in African Americans. Future direction and implications are discussed. Psychinfo, PubMed, Medline. © 2015 National Medical Association. Published by Elsevier Inc. All rights reserved.

A human factors approach to range scheduling for satellite control

NASA Technical Reports Server (NTRS)

Wright, Cameron H. G.; Aitken, Donald J.

1991-01-01

Range scheduling for satellite control presents a classical problem: supervisory control of a large-scale dynamic system, with unwieldy amounts of interrelated data used as inputs to the decision process. Increased automation of the task, with the appropriate human-computer interface, is highly desirable. The development and user evaluation of a semi-automated network range scheduling system is described. The system incorporates a synergistic human-computer interface consisting of a large screen color display, voice input/output, a 'sonic pen' pointing device, a touchscreen color CRT, and a standard keyboard. From a human factors standpoint, this development represents the first major improvement in almost 30 years to the satellite control network scheduling task.

Power Grid Maintenance Scheduling Intelligence Arrangement Supporting System Based on Power Flow Forecasting

NASA Astrophysics Data System (ADS)

Xie, Chang; Wen, Jing; Liu, Wenying; Wang, Jiaming

With the development of intelligent dispatching, the intelligence level of network control center full-service urgent need to raise. As an important daily work of network control center, the application of maintenance scheduling intelligent arrangement to achieve high-quality and safety operation of power grid is very important. By analyzing the shortages of the traditional maintenance scheduling software, this paper designs a power grid maintenance scheduling intelligence arrangement supporting system based on power flow forecasting, which uses the advanced technologies in maintenance scheduling, such as artificial intelligence, online security checking, intelligent visualization techniques. It implements the online security checking of maintenance scheduling based on power flow forecasting and power flow adjusting based on visualization, in order to make the maintenance scheduling arrangement moreintelligent and visual.

A Comparison of Escalating versus Fixed Reinforcement Schedules on Undergraduate Quiz Taking

ERIC Educational Resources Information Center

Mahoney, Amanda

2017-01-01

Drug abstinence studies indicate that escalating reinforcement schedules maintain abstinence for longer periods than fixed reinforcement schedules. The current study evaluated whether escalating reinforcement schedules would maintain more quiz taking than fixed reinforcement schedules. During baseline and for the control group, bonus points were…

Electro-acupuncture for pain relief after nasal septoplasty: a randomized controlled study.

PubMed

Sahmeddini, Mohammad A; Farbood, Arash; Ghafaripuor, Sina

2010-01-01

Electro-acupuncture (EA) can be effective in some pain conditions, but still there have been no randomized controlled studies of EA for treatment of acute postoperative pain in nasal septoplasty. Therefore, we did a study to test whether EA of specific points is superior to sham acupuncture for complementary analgesia after nasal septoplasty. Ninety (90) patients with an American Society of Anesthesiology (ASA) physical status of I-II scheduled for elective septoplasty were randomly allocated to acupuncture group or control group. Postoperative pain was treated with intravenous meperidine. The time to the first analgesic request, and pain intensity on a 100-mm visual analogue scale (VAS-100) were used to evaluate postoperative pain, and the amount of postoperative meperidine and incidence of analgesia related to side-effects were recorded. Postoperative pain intensity on VAS-100 and respiratory depression were similar in both groups (p > 0.05), but nausea and vomiting were less in the acupuncture group than in the control group (p < 0.05). Findings from our study demonstrate that both uses of EA and 0.1 mg/kg IV morphine given intraoperatively resulted in a similar postoperative pain score, and meperidine was not given in any patient in the two groups during postoperative period because the VAS scores of all patients were less than 40 mm.

77 FR 38086 - Manufacturer of Controlled Substances; Notice of Application; Chemica

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... bulk manufacturer of Methamphetamine (1105), a basic class of controlled substance listed in schedule... schedule III non-narcotic controlled substance. The methamphetamine will not be sold as a commercial...

Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine.

PubMed

Ranaldi, R; Anderson, K G; Carroll, F I; Woolverton, W L

2000-12-01

The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a monoamine uptake blocker would block behavioral effects of MA related to its abuse. RTI 111, a newly synthesized 3-phenyltropane analog with high affinity for the dopamine, norepinephrine, and serotonin transporters, was evaluated alone and in combination with MA for its ability to block the reinforcing and discriminative stimulus effects of MA in rhesus monkeys. RTI 111 (0.0003-0.03 mg/kg, i.v.) was made available to four rhesus monkeys for self-administration under a fixed-ratio 25 (FR 25) schedule of reinforcement. RTI 111 (0.01-0.1 mg/kg, i.m.) was also administered as a pretreatment (15 min prior) to four monkeys self-administering MA (0.0-0.3 mg/kg per injection, i.v.) on a progressive-ratio schedule of reinforcement. MA (0.01-1.0 mg/kg, i.m.), RTI 111 (0.001-0.1 mg/kg, i.m.), or the combination of MA and RTI 111 were administered to four monkeys trained to discriminate (+)-amphetamine (AMPH; 1.0 or 1.7 mg/kg, intragastric) from saline. When RTI 111 was made available for self-administration under an FR 25 schedule it functioned as a positive reinforcer in all four monkeys tested. When RTI 111 was given as a pretreatment to monkeys self-administering MA under a progressive-ratio schedule, the MA dose-response function shifted to the left and down. When RTI 111 or MA were given to monkeys trained to discriminate AMPH from saline, full AMPH-like responding was observed for both drugs. Given in combination, RTI 111 shifted the MA dose-response function to the left. These data suggest that RTI 111 is behaviorally similar to traditional psychomotor stimulants that act at the DA transporter and that it increases, rather than blocks, the behavioral potency of MA.

Psychomotor stimulant effects of beta-phenylethylamine in monkeys treated with MAO-B inhibitors.

PubMed

Bergman, J; Yasar, S; Winger, G

2001-12-01

Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). The present experiments were conducted to study how the discriminative-stimulus (S(D)) and reinforcing-stimulus (S(R)) effects of beta-PEA in monkeys are modified by treatment with inhibitors of MAO-B [R-(-)-deprenyl and MDL 72974]. In studies of its S(D) effects, doses of beta-PEA up to 30 mg/kg engendered only sporadic responding on the drug-associated lever in squirrel monkeys that discriminated intramuscular injections of 0.3 mg/kg MA from vehicle whereas lower doses of 0.3-1.0 mg/kg beta-PEA produced full substitution when administered after either R-(-)-deprenyl or MDL 72974 (0.3 mg/kg). The MA-like S(D) effects of beta-PEA were attenuated by either dopamine D(1) or D(2) receptor blockers. In studies of its S(R) effects, high doses of beta-PEA maintained responding in two of three monkeys under a second-order fixed-interval schedule (3.0 or 10 mg/kg per injection) and two of three monkeys under a simple fixed ratio (FR) schedule (0.3-1.0 mg/kg per injection) of intravenous (i.v.) self-administration. MAO-B inhibition by R-(-)-deprenyl or MDL 72974 enhanced the S(R) effects of beta-PEA in all monkeys and, under the FR schedule, induced a 30-fold or greater leftward shift in the dose-response function for its i.v. self-administration. Based on time-course determinations, the enhanced S(R) effects of beta-PEA under the FR schedule were long-lasting and dissipated gradually over 3-7 days. These results show that inhibition of MAO-B enhances S(D) and S(R) effects of beta-PEA in monkeys, presumably by delaying its inactivation. MAO-B inhibition leading to increased levels of beta-PEA may be useful, alone or in combination with other therapeutic agents, in the pharmacological management of selected aspects of drug dependence.

Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA and MDMB-FUBINACA) into Schedule I. Temporary Scheduling Order.

PubMed

2017-04-10

The Administrator of the Drug Enforcement Administration is issuing this temporary scheduling order to schedule six synthetic cannabinoids: methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]; methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]; N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]; methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA] and methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA], and their optical, positional, and geometric isomers, salts, and salts of isomers into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act. This action is based on a finding by the Administrator that the placement of these synthetic cannabinoids into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle, 5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-CHMICA or MDMB-FUBINACA.

Anchorage Arrival Scheduling Under Off-Nominal Weather Conditions

NASA Technical Reports Server (NTRS)

Grabbe, Shon; Chan, William N.; Mukherjee, Avijit

2012-01-01

Weather can cause flight diversions, passenger delays, additional fuel consumption and schedule disruptions at any high volume airport. The impacts are particularly acute at the Ted Stevens Anchorage International Airport in Anchorage, Alaska due to its importance as a major international portal. To minimize the impacts due to weather, a multi-stage scheduling process is employed that is iteratively executed, as updated aircraft demand and/or airport capacity data become available. The strategic scheduling algorithm assigns speed adjustments for flights that originate outside of Anchorage Center to achieve the proper demand and capacity balance. Similarly, an internal departure-scheduling algorithm assigns ground holds for pre-departure flights that originate from within Anchorage Center. Tactical flight controls in the form of airborne holding are employed to reactively account for system uncertainties. Real-world scenarios that were derived from the January 16, 2012 Anchorage visibility observations and the January 12, 2012 Anchorage arrival schedule were used to test the initial implementation of the scheduling algorithm in fast-time simulation experiments. Although over 90% of the flights in the scenarios arrived at Anchorage without requiring any delay, pre-departure scheduling was the dominant form of control for Anchorage arrivals. Additionally, tactical scheduling was used extensively in conjunction with the pre-departure scheduling to reactively compensate for uncertainties in the arrival demand. For long-haul flights, the strategic scheduling algorithm performed best when the scheduling horizon was greater than 1,000 nmi. With these long scheduling horizons, it was possible to absorb between ten and 12 minutes of delay through speed control alone. Unfortunately, the use of tactical scheduling, which resulted in airborne holding, was found to increase as the strategic scheduling horizon increased because of the additional uncertainty in the arrival times of the aircraft. Findings from these initial experiments indicate that it is possible to schedule arrivals into Anchorage with minimal delays under low-visibility conditions with less disruption to high-cost, international flights.

Switching State-Feedback LPV Control with Uncertain Scheduling Parameters

NASA Technical Reports Server (NTRS)

He, Tianyi; Al-Jiboory, Ali Khudhair; Swei, Sean Shan-Min; Zhu, Guoming G.

2017-01-01

This paper presents a new method to design Robust Switching State-Feedback Gain-Scheduling (RSSFGS) controllers for Linear Parameter Varying (LPV) systems with uncertain scheduling parameters. The domain of scheduling parameters are divided into several overlapped subregions to undergo hysteresis switching among a family of simultaneously designed LPV controllers over the corresponding subregion with the guaranteed H-infinity performance. The synthesis conditions are given in terms of Parameterized Linear Matrix Inequalities that guarantee both stability and performance at each subregion and associated switching surfaces. The switching stability is ensured by descent parameter-dependent Lyapunov function on switching surfaces. By solving the optimization problem, RSSFGS controller can be obtained for each subregion. A numerical example is given to illustrate the effectiveness of the proposed approach over the non-switching controllers.

Effect of reduced dose schedules and intramuscular injection of anthrax vaccine adsorbed on immunological response and safety profile: a randomized trial.

PubMed

Wright, Jennifer G; Plikaytis, Brian D; Rose, Charles E; Parker, Scott D; Babcock, Janiine; Keitel, Wendy; El Sahly, Hana; Poland, Gregory A; Jacobson, Robert M; Keyserling, Harry L; Semenova, Vera A; Li, Han; Schiffer, Jarad; Dababneh, Hanan; Martin, Sandra K; Martin, Stacey W; Marano, Nina; Messonnier, Nancy E; Quinn, Conrad P

2014-02-12

We evaluated an alternative administration route, reduced schedule priming series, and increased intervals between booster doses for anthrax vaccine adsorbed (AVA). AVA's originally licensed schedule was 6 subcutaneous (SQ) priming injections administered at months (m) 0, 0.5, 1, 6, 12 and 18 with annual boosters; a simpler schedule is desired. Through a multicenter randomized, double blind, non-inferiority Phase IV human clinical trial, the originally licensed schedule was compared to four alternative and two placebo schedules. 8-SQ group participants received 6 SQ injections with m30 and m42 "annual" boosters; participants in the 8-IM group received intramuscular (IM) injections according to the same schedule. Reduced schedule groups (7-IM, 5-IM, 4-IM) received IM injections at m0, m1, m6; at least one of the m0.5, m12, m18, m30 vaccine doses were replaced with saline. All reduced schedule groups received a m42 booster. Post-injection blood draws were taken two to four weeks following injection. Non-inferiority of the alternative schedules was compared to the 8-SQ group at m2, m7, and m43. Reactogenicity outcomes were proportions of injection site and systemic adverse events (AEs). The 8-IM group's m2 response was non-inferior to the 8-SQ group for the three primary endpoints of anti-protective antigen IgG geometric mean concentration (GMC), geometric mean titer, and proportion of responders with a 4-fold rise in titer. At m7 anti-PA IgG GMCs for the three reduced dosage groups were non-inferior to the 8-SQ group GMCs. At m43, 8-IM, 5-IM, and 4-IM group GMCs were superior to the 8-SQ group. Solicited injection site AEs occurred at lower proportions in the IM group compared to SQ. Route of administration did not influence the occurrence of systemic AEs. A 3 dose IM priming schedule with doses administered at m0, m1, and m6 elicited long term immunological responses and robust immunological memory that was efficiently stimulated by a single booster vaccination at 42 months. A priming series of 3 intramuscular doses administered at m0, m1, and m6 with a triennial booster was non-inferior to more complex schedules for achieving antibody response. Published by Elsevier Ltd.

75 FR 14188 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... this Section to a bulk manufacturer of a controlled substance in schedule I or II, and prior to issuing... Manufacturing LLC., 3500 Dekalb Street, St. Louis, Missouri 63118, made application by renewal to the Drug... listed in schedules I and II: Drug Schedule Cathinone (1235) I Methcathinone (1237) I Aminorex (1585) I...

Some effects of 8- vs 10-hour work schedules on the test performance/alertness of air traffic control specialists.

DOT National Transportation Integrated Search

1995-12-01

A 10-hour, 4-day rotating shift schedule worked by some Air Traffic Control Specialists (ATCSs) was compared to the more traditional 8-hour, 2-2-1 rapidly rotating schedule. Measures of performance and alertness were obtained from a group of 52 ATCSs...

The effects of signalled and unsignalled lick-dependent delays on the development of schedule-induced drinking in rats.

PubMed

Pellon, R; Blackman, D E

1991-02-01

Food pellets were programmed to be delivered to rats every 60 sec (Fixed Time 60-sec schedule), and the development of schedule-induced drinking was measured in terms of the amount of water consumed and the number of licks per inter-pellet interval. For some rats (masters) 10-sec delays in food delivery were dependent on licks. Yoked-control rats received food at the same time as their masters and independently of their own behaviour. In Experiment 1, in which the delays were signalled by a blackout, the master rats began to drink, but this schedule-induced behaviour then decreased to levels lower than those shown by the yoked controls. When the signalled delays were discontinued, the drinking of the master rats recovered. In Experiment 2, in which the delays were not signalled, the master rats did not develop as much schedule-induced drinking as the yoked controls, and discontinuing the delays led to only small increases in drinking. These results support the view that schedule-induced drinking is subject to control by its consequences.

Effects of d-amphetamine, diazepam and buspirone on schedule-induced polydipsia suppressed by response-dependent and response-independent shock.

PubMed

Flores, P; Pellón, R

1998-03-01

Food deprived Wistar rats were exposed to a fixed time 60 s food schedule until they developed schedule-induced polydipsia. Rats were matched in pairs according to their licking rate, being designated experimental or yoked control at random. Every fifth lick by experimental rats was then followed by an electric shock (0.05, 0.1, or 0.2 mA) while the food schedule continued in operation. Yoked-control rats received the same shocks as experimental rats, but independently of their own licking. Drugs were then tested on the suppressed rates of licking. Diazepam (0.5-2.0 mg/kg) increased punished schedule-induced polydipsia, a result not observed in yoked controls. No increases in the licks per minute of experimental or control animals were found after d-amphetamine (0.25-4.0 mg/kg) or buspirone (0.5-8.0 mg/kg). In comparison with previous results it is concluded that the antipunishment effects of drugs on schedule-induced behaviour depend on the type of punishment contingency.

Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection.

PubMed

Miura, Yuichiro; Payne, Matthew S; Keelan, Jeffrey A; Noe, Andres; Carter, Sean; Watts, Rory; Spiller, Owen B; Jobe, Alan H; Kallapur, Suhas G; Saito, Masatoshi; Stock, Sarah J; Newnham, John P; Kemp, Matthew W

2014-09-01

Intrauterine infection with Ureaplasma spp. is strongly associated with preterm birth and adverse neonatal outcomes. We assessed whether combined intraamniotic (IA) and maternal intravenous (IV) treatment with one of two candidate antibiotics, azithromycin (AZ) or solithromycin (SOLI), would eradicate intrauterine Ureaplasma parvum infection in a sheep model of pregnancy. Sheep with singleton pregnancies received an IA injection of U. parvum serovar 3 at 85 days of gestational age (GA). At 120 days of GA, animals (n=5 to 8/group) received one of the following treatments: (i) maternal IV SOLI with a single IA injection of vehicle (IV SOLI only); (ii) maternal IV SOLI with a single IA injection of SOLI (IV+IA SOLI); (iii) maternal IV AZ and a single IA injection of vehicle (IV AZ only); (iv) maternal IV AZ and a single IA injection of AZ (IV+IA AZ); or (v) maternal IV and single IA injection of vehicle (control). Lambs were surgically delivered at 125 days of GA. Treatment efficacies were assessed by U. parvum culture, quantitative PCR, enzyme-linked immunosorbent assay, and histopathology. Amniotic fluid (AF) from all control animals contained culturable U. parvum. AF, lung, and chorioamnion from all AZ- or SOLI-treated animals (IV only or IV plus IA) were negative for culturable U. parvum. Relative to the results for the control, the levels of expression of interleukin 1β (IL-1β), IL-6, IL-8, and monocyte chemoattractant protein 2 (MCP-2) in fetal skin were significantly decreased in the IV SOLI-only group, the MCP-1 protein concentration in the amniotic fluid was significantly increased in the IV+IA SOLI group, and there was no significant difference in the histological inflammation scoring of lung or chorioamnion among the five groups. In the present study, treatment with either AZ or SOLI (IV only or IV+IA) effectively eradicated macrolide-sensitive U. parvum from the AF. There was no discernible difference in antibiotic therapy efficacy between IV-only and IV+IA treatment regimens relative to the results for the control. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

[Epidural anaesthesia: Simulated intravascular test dose with S(+) ketamine, lidocaine and adrenaline. A prospective, randomized, double blind and placebo controlled study].

PubMed

Higueras, R; Errando, C L; Soriano-Bru, J L

2015-02-01

The use of a test dose in epidural anaesthesia is a safety recommendation. However specificity and sensitivity of the drugs used with this indication have been not conclusive. The main objective of this study was to compare the effectiveness and the adverse effects of a simulated intravascular test dose of adrenaline, lidocaine and S(+)-ketamine. A prospective, randomized, double blinded, placebo controlled study was designed. ASA I patients scheduled for elective surgery were included. These were randomized to the following study groups: S(+)-ketamine 0.5 mg.kg-1 (S+K group), 5% lidocaine 1.5 mg.kg-1 (L5% group), adrenaline 15μg (ADR group), and physiological saline 3 ml (SF group; control group). An evaluation was made during the first 15 minutes after the study drug was administered. Variables including heart rate (HR) systolic and diastolic blood pressure (sBP and dBP), mean arterial pressure (MAP), and SpO2 were recorded at 0 min (baseline) and at 2, 5, 8, 10 and 15 minutes after drug injection. An increase of at least 20 beats per minute (bpm) in relation to the baseline measurement was considered a positive result, as was an increase sBP >15 mmHg. The clinical effects described as related to iv injection of the study drugs recorded were: sedation-hypnosis, dizziness, nystagmus, metallic taste perception, perioral or facial paresthesias, tinnitus, as well as any other effect the patients mentioned. Sensitivity and specificity were calculated as was the percent increase in the parameters in order to see if these were clinically useful. A total of 80 patients, 20 per group, were included. The sBP, dBP, and MAP were significantly raised at the 2, 5, 8 and 10 minutes measurements in the S(+)K group compared to the rest of the groups (P<.05), as well as HR in the 2, 5, 8, 10 and 15 minute measurements in the S(+)K compared to the rest of the groups (P<.05). Sensitivity and specificity were high, and significant in the S(+)K group from minute 2 to minute 8 compared with the placebo group, as well as percentage points differences in the same interval. There were significant differences in the incidence of sedation-hypnosis, nystagmus and dizziness, which were more frequent in the S(+)K group. There were no differences in the incidence of metallic taste, perioral and facial paresthesias or tinnitus. The effects in the S(+)K group always occurred before minute 5 after drug injection. Both lidocaine an adrenaline at the scheduled doses showed low sensitivity and specificity as a simulated iv epidural test dose. S(+)-ketamine could be a feasible marker after accidental iv injection during epidural anaesthesia or analgesia. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

Development of Methodologies for IV and V of Neural Networks

NASA Technical Reports Server (NTRS)

Taylor, Brian; Darrah, Marjorie

2003-01-01

Non-deterministic systems often rely upon neural network (NN) technology to "lean" to manage flight systems under controlled conditions using carefully chosen training sets. How can these adaptive systems be certified to ensure that they will become increasingly efficient and behave appropriately in real-time situations? The bulk of Independent Verification and Validation (IV&V) research of non-deterministic software control systems such as Adaptive Flight Controllers (AFC's) addresses NNs in well-behaved and constrained environments such as simulations and strict process control. However, neither substantive research, nor effective IV&V techniques have been found to address AFC's learning in real-time and adapting to live flight conditions. Adaptive flight control systems offer good extensibility into commercial aviation as well as military aviation and transportation. Consequently, this area of IV&V represents an area of growing interest and urgency. ISR proposes to further the current body of knowledge to meet two objectives: Research the current IV&V methods and assess where these methods may be applied toward a methodology for the V&V of Neural Network; and identify effective methods for IV&V of NNs that learn in real-time, including developing a prototype test bed for IV&V of AFC's. Currently. no practical method exists. lSR will meet these objectives through the tasks identified and described below. First, ISR will conduct a literature review of current IV&V technology. TO do this, ISR will collect the existing body of research on IV&V of non-deterministic systems and neural network. ISR will also develop the framework for disseminating this information through specialized training. This effort will focus on developing NASA's capability to conduct IV&V of neural network systems and to provide training to meet the increasing need for IV&V expertise in such systems.

Control of human energy expenditure by cytochrome c oxidase subunit IV-2.

PubMed

Schiffer, Tomas A; Peleli, Maria; Sundqvist, Michaela L; Ekblom, Björn; Lundberg, Jon O; Weitzberg, Eddie; Larsen, Filip J

2016-09-01

Resting metabolic rate (RMR) in humans shows pronounced individual variations, but the underlying molecular mechanism remains elusive. Cytochrome c oxidase (COX) plays a key role in control of metabolic rate, and recent studies of the subunit 4 isoform 2 (COX IV-2) indicate involvement in the cellular response to hypoxia and oxidative stress. We evaluated whether the COX subunit IV isoform composition may explain the pronounced individual variations in resting metabolic rate (RMR). RMR was determined in healthy humans by indirect calorimetry and correlated to levels of COX IV-2 and COX IV-1 in vastus lateralis. Overexpression and knock down of the COX IV isoforms were performed in primary myotubes followed by evaluation of the cell respiration and production of reactive oxygen species. Here we show that COX IV-2 protein is constitutively expressed in human skeletal muscle and strongly correlated to RMR. Primary human myotubes overexpressing COX IV-2 displayed markedly (>60%) lower respiration, reduced (>50%) cellular H2O2 production, higher resistance toward both oxidative stress, and severe hypoxia compared with control cells. These results suggest an important role of isoform COX IV-2 in the control of energy expenditure, hypoxic tolerance, and mitochondrial ROS homeostasis in humans. Copyright © 2016 the American Physiological Society.

Discrimination of Variable Schedules Is Controlled by Interresponse Times Proximal to Reinforcement

ERIC Educational Resources Information Center

Tanno, Takayuki; Silberberg, Alan; Sakagami, Takayuki

2012-01-01

In Experiment 1, food-deprived rats responded to one of two schedules that were, with equal probability, associated with a sample lever. One schedule was always variable ratio, while the other schedule, depending on the trial within a session, was: (a) a variable-interval schedule; (b) a tandem variable-interval,…

On-the-fly scheduling as a manifestation of partial-order planning and dynamic task values.

PubMed

Hannah, Samuel D; Neal, Andrew

2014-09-01

The aim of this study was to develop a computational account of the spontaneous task ordering that occurs within jobs as work unfolds ("on-the-fly task scheduling"). Air traffic control is an example of work in which operators have to schedule their tasks as a partially predictable work flow emerges. To date, little attention has been paid to such on-the-fly scheduling situations. We present a series of discrete-event models fit to conflict resolution decision data collected from experienced controllers operating in a high-fidelity simulation. Our simulations reveal air traffic controllers' scheduling decisions as examples of the partial-order planning approach of Hayes-Roth and Hayes-Roth. The most successful model uses opportunistic first-come-first-served scheduling to select tasks from a queue. Tasks with short deadlines are executed immediately. Tasks with long deadlines are evaluated to assess whether they need to be executed immediately or deferred. On-the-fly task scheduling is computationally tractable despite its surface complexity and understandable as an example of both the partial-order planning strategy and the dynamic-value approach to prioritization.

Gain scheduling - Potential hazards and possible remedies

NASA Technical Reports Server (NTRS)

Shamma, Jeff S.; Athans, Michael

1991-01-01

A common gain scheduling rule-of-thumb is to schedule on a slow variable. In this work, it is shown how current gain scheduling practice is necessarily limited to slow variations in the scheduling variable. These limitations are revealed to be consequences of fundamental control concepts. Furthermore, it is shown how a formulation of the gain scheduling procedure can lead toward ultimately removing these restrictions.

Population pharmacokinetics of intravenous acetaminophen in Japanese patients undergoing elective surgery.

PubMed

Imaizumi, Tsuyoshi; Obara, Shinju; Mogami, Midori; Iseki, Yuzo; Hasegawa, Makiko; Murakawa, Masahiro

2017-06-01

Intravenous (i.v.) acetaminophen is administered during surgery for postoperative analgesia. However, little information is available on the pharmacokinetics of i.v. acetaminophen in Japanese patients undergoing surgery under general anesthesia. The study was approved by the Institutional Review Board and registered at UMIN-CTR (UMIN000013418). Patients scheduled to undergo elective surgery under general anesthesia were enrolled after obtaining written informed consent. During surgery, 1 g of i.v. acetaminophen was administered over 15, 60, or 120 min. Acetaminophen concentrations (15 or 16 samples per case) were measured at time points from 0-480 min after the start of administration (liquid chromatography-mass spectrometry/tandem mass spectrometry; limit of quantitation 0.1 μg/mL). The predictive performance of three published pharmacokinetic models was evaluated. Population pharmacokinetics were also analyzed using a nonlinear mixed-effect model based on the NONMEM program. Data from 12 patients who underwent endoscopic or lower limb procedures were analyzed (male/female = 7/5, median age 55 years, weight 63 kg). Anesthesia was maintained with remifentanil and propofol or sevoflurane. The pharmacokinetic model of i.v. acetaminophen reported by Würthwein et al. worked well. Using 185 datapoints, the pharmacokinetics of i.v. acetaminophen were described by a two-compartment model with weight as a covariate but not age, sex, or creatinine clearance. The median prediction error and median absolute prediction error of the final model were -1 and 10%, respectively. A population pharmacokinetic model of i.v. acetaminophen in Japanese patients was constructed, with performance within acceptable ranges.

Scheduler for monitoring objects orbiting earth using satellite-based telescopes

DOEpatents

Olivier, Scot S; Pertica, Alexander J; Riot, Vincent J; De Vries, Willem H; Bauman, Brian J; Nikolaev, Sergei; Henderson, John R; Phillion, Donald W

2015-04-28

An ephemeris refinement system includes satellites with imaging devices in earth orbit to make observations of space-based objects ("target objects") and a ground-based controller that controls the scheduling of the satellites to make the observations of the target objects and refines orbital models of the target objects. The ground-based controller determines when the target objects of interest will be near enough to a satellite for that satellite to collect an image of the target object based on an initial orbital model for the target objects. The ground-based controller directs the schedules to be uploaded to the satellites, and the satellites make observations as scheduled and download the observations to the ground-based controller. The ground-based controller then refines the initial orbital models of the target objects based on the locations of the target objects that are derived from the observations.

Air Traffic Controllers' Control Strategies in the Terminal Area Under Off-Nominal Conditions

NASA Technical Reports Server (NTRS)

Martin, Lynne; Mercer, Joey; Callantine, Todd; Kupfer, Michael; Cabrall, Christopher

2012-01-01

A human-in-the-loop simulation investigated the robustness of a schedule-based terminal-area air traffic management concept, and its supporting controller tools, to off-nominal events - events that led to situations in which runway arrival schedules required adjustments and controllers could no longer use speed control alone to impose the necessary delays. The main research question was exploratory: to assess whether controllers could safely resolve and control the traffic during off-nominal events. A focus was the role of the supervisor - how he managed the schedules, how he assisted the controllers, what strategies he used, and which combinations of tools he used. Observations and questionnaire responses revealed supervisor strategies for resolving events followed a similar pattern: a standard approach specific to each type of event often resolved to a smooth conclusion. However, due to the range of factors influencing the event (e.g., environmental conditions, aircraft density on the schedule, etc.), sometimes the plan required revision and actions had a wide-ranging effect.

KSC-2013-2880

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida. From the left, are Nico Dettman, ESA Space Transportation Department director Bernardo Patti, ESA manager of International Space Station Operations Philippe Deloo, ESA European Service Module study manager and Mark Geyer, Orion Production Operations manager. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-2884

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay and viewed the Orion crew module at NASA’s Kennedy Space Center in Florida. Among the group were Nico Dettman, ESA Space Transportation Department director Bernardo Patti, ESA International Space Station Operations manager and Philippe Deloo, ESA European Service Module Study manager. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Alterations of type IV collagen alpha chains in patients with chronic acquired glomerulopathies: mRNA levels, protein expression and urinary loss.

PubMed

Sanna-Cherchi, Simone; Carnevali, Maria Luisa; Martorana, Davide; Cravedi, Paolo; Maggiore, Umberto; Alinovi, Rossella; Bovino, Achiropita; Mattei, Silvia; Orlandini, Guido; Gatti, Rita; Savi, Mario; Sado, Yoshikazu; Neri, Tauro M; Allegri, Landino

2007-01-01

Type IV collagen is a major structural component of the normal kidney glomerulus. However, its role in chronic acquired glomerulopathies has been only partially elucidated. Urinary levels of col(IV)alpha1, col(IV)alpha3 and col(IV)alpha5 collagen chains were analyzed in 107 patients with chronic acquired glomerulopathies. In a subgroup of 33 patients, tissue mRNA levels, protein expression and urinary excretion were evaluated for all col(IV)alpha chains, from col(IV)alpha1 to col(IV)alpha5. The renal specimens were examined to get a semiquantitative score of the acute and chronic activity of the histological lesions. Urines obtained from 13 healthy subjects and 10 normal renal tissue samples were used as controls. Urinary levels of col(IV)alpha1, col(IV)alpha3, col(IV)alpha5 chains were significantly higher in patients than in controls [p < 0.01 for all], while only col(IV)alpha1 and col(IV)alpha3 urinary excretion correlated with the degree of chronic histological damage [col(IV)alpha1 R = 0.44, p < 0.001; col(IV)alpha3: R = 0.47, p < 0.001]. Compared with controls, patients showed a renal expression of mRNA for col(IV)alpha5 chain significantly higher [p = 0.001], while having a significantly lower protein expression of col(IV)alpha3, col(IV)alpha4 and col(IV)alpha5 chains [p < 0.01 for all]. Patients with chronic acquired glomerulopathies show important alterations in the col(IV)alpha chain network mimicking some molecular features of the X-linked Alport's syndrome. Further studies are needed to show whether urinary levels of the col(IV)alpha chains may be used as markers for monitoring renal injury. Copyright 2007 S. Karger AG, Basel.

A Fast and Scalable Algorithm for Calculating the Achievable Capacity of a Wireless Mesh Network

DTIC Science & Technology

2016-05-09

an optimal wireless transmission schedule for a predetermined set of links without the addition of routing is NP-Hard [5]. We effectively bypass the... wireless communications have used omni-directional antennas, where a user’s transmission inter- feres with others users in all directions. Different...interference from some particular transmission . Hence, δ = ∆(Ḡc) = max(i,j)∈E |Fij |. IV. ALGORITHM FOR RAPIDLY DETERMINING WIRELESS NETWORK CAPACITY In

Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies.

PubMed

Mouridsen, H T; Langer, S W; Buter, J; Eidtmann, H; Rosti, G; de Wit, M; Knoblauch, P; Rasmussen, A; Dahlstrøm, K; Jensen, P B; Giaccone, G

2007-03-01

The purpose of this study was to assess the efficacy and tolerability of i.v. dexrazoxane [Savene (EU), Totect (US)] as acute antidote in biopsy-verified anthracycline extravasation. Two prospective, open-label, single-arm, multicentre studies in patients with anthracycline extravasation were carried out. Patients with fluorescence-positive tissue biopsies were treated with a 3-day schedule of i.v. dexrazoxane (1000, 1000, and 500 mg/m(2)) starting no later than 6 h after the incident. Patients were assessed for efficacy (the possible need for surgical resection) and toxicity during the treatment period and regularly for the next 3 months. In 53 of 54 (98.2%) patients assessable for efficacy, the treatment prevented surgery-requiring necrosis. One patient (1.8%) required surgical debridement. Thirty-eight patients (71%) were able to continue their scheduled chemotherapy without postponement. Twenty-two patients (41%) experienced hospitalisation due to the extravasation. Mild pain (10 patients; 19%) and mild sensory disturbances (nine patients; 17%) were the most frequent sequelae. Haematologic toxicity was common as expected from the fact that the extravasation occurred during a chemotherapy course. Other toxic effects were transient elevation of alanine aminotransferases, nausea, and local pain at the dexrazoxane injection site. Dexrazoxane proved to be an effective and well-tolerated acute treatment with only one out of 54 assessable patients requiring surgical resection (1.8%).

Reliable gain-scheduled control of discrete-time systems and its application to CSTR model

NASA Astrophysics Data System (ADS)

Sakthivel, R.; Selvi, S.; Mathiyalagan, K.; Shi, Y.

2016-10-01

This paper is focused on reliable gain-scheduled controller design for a class of discrete-time systems with randomly occurring nonlinearities and actuator fault. Further, the nonlinearity in the system model is assumed to occur randomly according to a Bernoulli distribution with measurable time-varying probability in real time. The main purpose of this paper is to design a gain-scheduled controller by implementing a probability-dependent Lyapunov function and linear matrix inequality (LMI) approach such that the closed-loop discrete-time system is stochastically stable for all admissible randomly occurring nonlinearities. The existence conditions for the reliable controller is formulated in terms of LMI constraints. Finally, the proposed reliable gain-scheduled control scheme is applied on continuously stirred tank reactor model to demonstrate the effectiveness and applicability of the proposed design technique.

A comparison of multiprocessor scheduling methods for iterative data flow architectures

NASA Technical Reports Server (NTRS)

Storch, Matthew

1993-01-01

A comparative study is made between the Algorithm to Architecture Mapping Model (ATAMM) and three other related multiprocessing models from the published literature. The primary focus of all four models is the non-preemptive scheduling of large-grain iterative data flow graphs as required in real-time systems, control applications, signal processing, and pipelined computations. Important characteristics of the models such as injection control, dynamic assignment, multiple node instantiations, static optimum unfolding, range-chart guided scheduling, and mathematical optimization are identified. The models from the literature are compared with the ATAMM for performance, scheduling methods, memory requirements, and complexity of scheduling and design procedures.

Schedules of controlled substances: extension of temporary placement of UR-144, XLR11, and AKB48 in schedule I of the Controlled Substances Act. Final order.

PubMed

2015-05-15

The Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to extend the temporary placement of (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144), [1-(5-fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone (5-fluoro-UR-144, XLR11) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA, AKB48), including their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, in schedule I of the Controlled Substances Act. The current final order temporarily placing UR-144, XLR11, and AKB48 in schedule I is due to expire on May 15, 2015. This final order will extend the temporary scheduling of UR-144, XLR11, and AKB48 to May 15, 2016, or until the permanent scheduling action for these three substances is completed, whichever occurs first.

Study on ecological regulation of coastal plain sluice

NASA Astrophysics Data System (ADS)

Yu, Wengong; Geng, Bing; Yu, Huanfei; Yu, Hongbo

2018-02-01

Coastal plains are densely populated and economically developed, therefore their importance is self-evident. However, there are some problems related with water in coastal plains, such as low flood control capacity and severe water pollution. Due to complicated river network hydrodynamic force, changeable flow direction and uncertain flood concentration and propagation mechanism, it is rather difficult to use sluice scheduling to realize flood control and tackle water pollution. On the base of the measured hydrological data during once-in-a-century Fitow typhoon in 2013 in Yuyao city, by typical analysis, theoretical analysis and process simulation, some key technologies were researched systematically including plain river network sluice ecological scheduling, “one tide” flood control and drainage scheduling and ecological running water scheduling. In the end, single factor health diagnostic evaluation, unit hydrograph of plain water level and evening tide scheduling were put forward.

Future applications of artificial intelligence to Mission Control Centers

NASA Technical Reports Server (NTRS)

Friedland, Peter

1991-01-01

Future applications of artificial intelligence to Mission Control Centers are presented in the form of the viewgraphs. The following subject areas are covered: basic objectives of the NASA-wide AI program; inhouse research program; constraint-based scheduling; learning and performance improvement for scheduling; GEMPLAN multi-agent planner; planning, scheduling, and control; Bayesian learning; efficient learning algorithms; ICARUS (an integrated architecture for learning); design knowledge acquisition and retention; computer-integrated documentation; and some speculation on future applications.

Schedules of Controlled Substances: Placement of UR-144, XLR11, and AKB48 into Schedule I. Final rule.

PubMed

2016-05-11

With the issuance of this final rule, the Drug Enforcement Administration places (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144), [1-(5-fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone (5-fluoro-UR-144, XLR11), and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA, AKB48), including their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act which requires that such actions be made on the record after opportunity for a hearing through formal rulemaking. This action imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle UR-144, XLR11, or AKB48.

Subcutaneous Crotaline Fab antivenom for the treatment of rattlesnake envenomation in a porcine model.

PubMed

Offerman, Steven R; Barry, J David; Richardson, William H; Tong, Tri; Tanen, Dave; Bush, Sean P; Clark, Richard F

2009-01-01

This study was designed to investigate whether the local, subcutaneous injection of Crotaline Fab antivenom (CroFab) at the rattlesnake envenomation site would result in less extremity edema when compared to intravenous (i.v.) antivenom infusion alone. This is a randomized, three-arm laboratory experiment using a porcine model. Each animal was anesthetized, intubated, and maintained on mechanical ventilation. About 6 mg/kg of Crotalus atrox venom was injected subcutaneously at the hock of the right hind leg. Animals were then randomized to immediately receive subcutaneous and i.v. antivenom (SC/IV), i.v. antivenom only, or saline control. SC/IV animals received two vials of CroFab subcutaneously at the envenomation site and two vials intravenously. IV animals received four vials of CroFab intravenously. Limb edema was tracked by serial circumference and volumetric measurements over an 8-h period. Limb circumference was measured at four pre-determined locations hourly. Limb volume was measured by a water displacement method at baseline, 4, and 8 h. Twenty-six animals were randomized to the three treatment groups. The SC/IV and IV arms included nine animals each. Two animals in the SC/IV group died suddenly during the study, leaving seven animals for data analysis. There were eight controls. Increasing limb edema was observed in all groups. No differences were detected in limb circumferences or limb volumes between control and either treatment arms. In this porcine model of crotaline envenomation, no differences in limb edema were found between animals treated with SC/IV or IV CroFab when compared to saline controls.

Job Scheduling Under the Portable Batch System

NASA Technical Reports Server (NTRS)

Henderson, Robert L.; Woodrow, Thomas S. (Technical Monitor)

1995-01-01

The typical batch queuing system schedules jobs for execution by a set of queue controls. The controls determine from which queues jobs may be selected. Within the queue, jobs are ordered first-in, first-run. This limits the set of scheduling policies available to a site. The Portable Batch System removes this limitation by providing an external scheduling module. This separate program has full knowledge of the available queued jobs, running jobs, and system resource usage. Sites are able to implement any policy expressible in one of several procedural language. Policies may range from "bet fit" to "fair share" to purely political. Scheduling decisions can be made over the full set of jobs regardless of queue or order. The scheduling policy can be changed to fit a wide variety of computing environments and scheduling goals. This is demonstrated by the use of PBS on an IBM SP-2 system at NASA Ames.

An Example of Discovery Research Involving the Transfer of Stimulus Control

PubMed Central

2005-01-01

The initial purpose of the present study was to replicate procedures for teaching preschool children to recruit attention at appropriate times by having an experimenter signal the availability and unavailability of attention (i.e., arrange a multiple schedule involving reinforcement and extinction; Tiger & Hanley, 2004). Following the development of discriminated social responding, the schedule-correlated stimuli were removed (i.e., a mixed schedule of reinforcement was arranged). However, discriminated responding continued during these conditions. Further evaluation suggested that stimulus control over children's social responding had transferred from the schedule-correlated stimuli to the delivery of reinforcement. The effect of a history of reinforcement under multiple-schedule conditions on performance under mixed schedules was then replicated with 2 participants in a reversal design. These findings suggest that following experience with schedule-correlated stimuli, these stimuli may be removed with only modest disruption to discriminated responding. PMID:16463530

ESSOPE: Towards S/C operations with reactive schedule planning

NASA Technical Reports Server (NTRS)

Wheadon, J.

1993-01-01

The ESSOPE is a prototype front-end tool running on a Sun workstation and interfacing to ESOC's MSSS spacecraft control system for the exchange of telecommand requests (to MSSS) and telemetry reports (from MSSS). ESSOPE combines an operations Planner-Scheduler, with a Schedule Execution Control function. Using an internal 'model' of the spacecraft, the Planner generates a schedule based on utilization requests for a variety of payload services by a community of Olympus users, and incorporating certain housekeeping operations. Conflicts based on operational constraints are automatically resolved, by employing one of several available strategies. The schedule is passed to the execution function which drives MSSS to perform it. When the schedule can no longer be met, either because the operator interferes (by delays or changes of requirements), or because ESSOPE has recognized some spacecraft anomalies, the Planner produces a modified schedule maintaining the on-going procedures as far as consistent with the new constraints or requirements.

The Dynamic Planner: The Sequencer, Scheduler, and Runway Allocator for Air Traffic Control Automation

NASA Technical Reports Server (NTRS)

Wong, Gregory L.; Denery, Dallas (Technical Monitor)

2000-01-01

The Dynamic Planner (DP) has been designed, implemented, and integrated into the Center-TRACON Automation System (CTAS) to assist Traffic Management Coordinators (TMCs), in real time, with the task of planning and scheduling arrival traffic approximately 35 to 200 nautical miles from the destination airport. The TMC may input to the DP a series of current and future scheduling constraints that reflect the operation and environmental conditions of the airspace. Under these constraints, the DP uses flight plans, track updates, and Estimated Time of Arrival (ETA) predictions to calculate optimal runway assignments and arrival schedules that help ensure an orderly, efficient, and conflict-free flow of traffic into the terminal area. These runway assignments and schedules can be shown directly to controllers or they can be used by other CTAS tools to generate advisories to the controllers. Additionally, the TMC and controllers may override the decisions made by the DP for tactical considerations. The DP will adapt to computations to accommodate these manual inputs.

Autism Spectrum Disorder in the DSM-5: Diagnostic Sensitivity and Specificity in Early Childhood.

PubMed

Christiansz, Jessica A; Gray, Kylie M; Taffe, John; Tonge, Bruce J

2016-06-01

Changes to the DSM-5 Autism Spectrum Disorder (ASD) criteria raised concerns among parents and practitioners that the criteria may exclude some children with Pervasive Developmental Disorder (PDD). Few studies have examined DSM-5 sensitivity and specificity in children less than 5 years of age. This study evaluated 185 children aged 20-55 months with DSM-IV PDD or developmental delay. Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) data was assigned to DSM-5 subdomains. Children displaying the required symptomatology were classified with DSM-5 ASD. DSM-IV clinical diagnoses were compared to DSM-5 classifications. Using combined ADI-R/ADOS information, sensitivity was .84 and specificity was .54. Comorbid behaviour and emotional problems were significantly lower in children with PDD that did not meet DSM-5 criteria.

Cassini is moved to Pad 40, CCAS, and placed atop its Titan IV launcher

NASA Technical Reports Server (NTRS)

1997-01-01

The Cassini spacecraft is rolled out of the Payload Hazardous Servicing Facility (PHSF) at Kennedy Space Center, Fla., shortly before being transported to Complex 40 at Cape Canaveral Air Station (CCAS) where it will be lifted to the top of its Titan IV/Centaur launch vehicle. Cassini is an international mission conducted by the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), and the Italian Space Agency (ASI). The two-story-tall spacecraft, scheduled for launch on Oct. 6, is destined to arrive at Saturn in July 2004, where it will orbit and study Saturn, its rings, moons and magnetic environment in detail over a four-year period. The Cassini mission is managed for NASA's Office of Space Science by the Jet Propulsion Laboratory, a division of the California Institute of Technology.

KSC-2014-4444

NASA Image and Video Library

2014-11-12

CAPE CANAVERAL, Fla. - The Orion spacecraft and its transporter stand at the base of the service structure at Space Launch Complex 37. A crane inside the structure will lift Orion off its transporter to hoist it into place atop the Delta IV Heavy rocket that is already assembled at the pad. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch Dec. 4, 2014, atop a United Launch Alliance Delta IV Heavy rocket, and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion Photo credit: Photo credit: NASA/Frankie Martin

A heuristic approach to incremental and reactive scheduling

NASA Technical Reports Server (NTRS)

Odubiyi, Jide B.; Zoch, David R.

1989-01-01

An heuristic approach to incremental and reactive scheduling is described. Incremental scheduling is the process of modifying an existing schedule if the initial schedule does not meet its stated initial goals. Reactive scheduling occurs in near real-time in response to changes in available resources or the occurrence of targets of opportunity. Only minor changes are made during both incremental and reactive scheduling because a goal of re-scheduling procedures is to minimally impact the schedule. The described heuristic search techniques, which are employed by the Request Oriented Scheduling Engine (ROSE), a prototype generic scheduler, efficiently approximate the cost of reaching a goal from a given state and effective mechanisms for controlling search.

Operations Manual for the National Center for Physical Acoustics Infrasound Microphone

DTIC Science & Technology

2013-02-01

thumbdrive.) There are three sections of the configuration file that can be edited: sensorConfig, adcConfig and autoControl . Modifying any other...for autoControl autoControl = { options = ( { doSchedule = 0; if nonzero, hourly scheduler is enabled

Schedules of controlled substances: temporary placement of three synthetic cannabinoids into Schedule I. Final order.

PubMed

2013-05-16

The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule three synthetic cannabinoids under the Controlled Substances Act (CSA) pursuant to the temporary scheduling provisions of 21 U.S.C. 811(h). The substances are (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144), [1-(5-fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone (5-fluoro-UR-144, XLR11) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA, AKB48). This action is based on a finding by the Deputy Administrator that the placement of these synthetic cannabinoids and their salts, isomers and salts of isomers into Schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the full effect of the CSA and the Controlled Substances Import and Export Act (CSIEA) and their implementing regulations including criminal, civil and administrative penalties, sanctions and regulatory controls of Schedule I substances will be imposed on the manufacture, distribution, possession, importation, and exportation of these synthetic cannabinoids.

Comparison of Effectiveness of Betamethasone gel Applied to the Tracheal Tube and IV Dexamethasone on Postoperative Sore Throat: A Randomized Controlled Trial.

PubMed

Tabari, Masumeh; Soltani, Ghasem; Zirak, Nahid; Alipour, Moammad; Khazaeni, Kamran

2013-09-01

Postoperative sore throat is a common complaint in patients with endotracheal intubation and has potentially dangerous complications. This randomized controlled trial study investigated the incidence of postoperative sore throat after general anesthesia when betamethasone gel is applied to a tracheal tube compared with when IV dexamethasone is prescribed. Two hundred and twenty five American Society of Anesthesiologist (ASA)-class I and II patients undergoing elective abdominal surgery with tracheal intubation were randomly divided into three groups: betamethasone gel, intravenous (IV) dexamethasone, and control groups. In the post-anesthesia care unit, a blinded anesthesiologist interviewed all patients regarding postoperative sore throat at 1,6, and 24 hours after surgery. The incidence of sore throat was significantly lower in the betamethasone gel group compared with the IV dexamethasone and control groups, 1, 6, and 24 hours after surgery. In the first day after surgery 10.7% of the betamethasone group had sore throat whereas 26.7% of the IV dexamethasone group and 30.7% of the control group had sore throat. Bucking before extubation was observed in 14(18.4%), 8(10.4%), and 9(12.2%) patients, in the IV dexamethasone, betamethasone gel, and control group, respectively. We concluded that wide spread application of betamethasone gel over tracheal tubes effectively mitigates postoperative sore throat, compared with IV dexamethasone application.

Tretinoin Nanogel 0.025% Versus Conventional Gel 0.025% in Patients with Acne Vulgaris: A Randomized, Active Controlled, Multicentre, Parallel Group, Phase IV Clinical Trial

PubMed Central

Chandrashekhar, B S; Anitha, M.; Ruparelia, Mukesh; Vaidya, Pradyumna; Aamir, Riyaz; Shah, Sunil; Thilak, S; Aurangabadkar, Sanjeev; Pal, Sandeep; Saraswat, Abir

2015-01-01

Background: Conventional topical tretinoin formulation is often associated with local adverse events. Nanogel formulation of tretinoin has good physical stability and enables good penetration of tretinoin into the pilo-sebaceous glands. Aim: The present study was conducted to assess the efficacy and safety of a nanogel formulation of tretinoin as compared to its conventional gel formulation in the treatment of acne vulgaris of the face. Materials and Methods: This randomized, active controlled, multicentric, phase IV clinical trial evaluated the treatment of patients with acne vulgaris of the face by the two gel formulations locally applied once daily at night for 12 wk. Acne lesion counts (inflammatory, non-inflammatory & total) and severity grading were carried out on the monthly scheduled visits along with the tolerability assessments. Results: A total of 207 patients were randomized in the study. Reductions in the total (72.9% vs. 65.0%; p = 0.03) and inflammatory (78.1% vs. 66.9%; p = 0.02) acne lesions were reported to be significantly greater with the nanogel formulation as compared to the conventional gel formulation. Local adverse events were significantly less (p = 0.04) in the nanogel group (13.3%) as compared to the conventional gel group (24.7%). Dryness was the most common adverse event reported in both the treatment groups while peeling of skin, burning sensation and photosensitivity were reported in patients using the conventional gel only. Conclusion: In the treatment of acne vulgaris of the face, tretinoin nanogel formulation appears to be more effective and better tolerated than the conventional gel formulation. PMID:25738069

Human's choices in situations of time-based diminishing returns.

PubMed Central

Hackenberg, T D; Axtell, S A

1993-01-01

Three experiments examined adult humans' choices in situations with contrasting short-term and long-term consequences. Subjects were given repeated choices between two time-based schedules of points exchangeable for money: a fixed schedule and a progressive schedule that began at 0 s and increased by 5 s with each point delivered by that schedule. Under "reset" conditions, choosing the fixed schedule not only produced a point but it also reset the requirements of the progressive schedule to 0 s. In the first two experiments, reset conditions alternated with "no-reset" conditions, in which progressive-schedule requirements were independent of fixed-schedule choices. Experiment 1 entailed choices between a progressive-interval schedule and a fixed-interval schedule, the duration of which varied across conditions. Switching from the progressive- to the fixed-interval schedule was systematically related to fixed-interval size in 4 of 8 subjects, and in all subjects occurred consistently sooner in the progressive-schedule sequence under reset than under no-reset procedures. The latter result was replicated in a second experiment, in which choices between progressive- and fixed-interval schedules were compared with choices between progressive- and fixed-time schedules. In Experiment 3, switching patterns under reset conditions were unrelated to variations in intertrial interval. In none of the experiments did orderly choice patterns depend on verbal descriptions of the contingencies or on schedule-controlled response patterns in the presence of the chosen schedules. The overall pattern of results indicates control of choices by temporarily remote consequences, and is consistent with versions of optimality theory that address performance in situations of diminishing returns. PMID:8315364

Linkage mapping of a mouse gene, iv, that controls left-right asymmetry of the heart and viscera.

PubMed Central

Brueckner, M; D'Eustachio, P; Horwich, A L

1989-01-01

Inherited single gene defects have been identified in both humans and mice that lead to loss of developmental control over the left-right asymmetry of the heart and viscera. In mice the recessively inherited mutation iv leads to such apparent loss of control over situs: 50% of iv/iv mice exhibit situs inversus and 50% exhibit normal situs. The affected gene product has not been identified in these animals. To study the normal function of iv, we have taken an approach directed to the gene itself. As a first step, we have mapped iv genetically, by examining its segregation in backcrosses with respect to markers defined by restriction fragment length polymorphisms. The iv locus lies 3 centimorgans (cM) from the immunoglobulin heavy-chain constant-region gene complex (Igh-C) on chromosome 12. A multilocus map of the region suggests the gene order centromere-Aat (alpha 1-antitrypsin gene complex)-(11 cM)-iv-(3 cM)-Igh-C-(1 cM)-Igh-V (immunoglobulin heavy-chain variable-region gene complex). Images PMID:2740340

The Business Change Initiative: A Novel Approach to Improved Cost and Schedule Management

NASA Technical Reports Server (NTRS)

Shinn, Stephen A.; Bryson, Jonathan; Klein, Gerald; Lunz-Ruark, Val; Majerowicz, Walt; McKeever, J.; Nair, Param

2016-01-01

Goddard Space Flight Center's Flight Projects Directorate employed a Business Change Initiative (BCI) to infuse a series of activities coordinated to drive improved cost and schedule performance across Goddard's missions. This sustaining change framework provides a platform to manage and implement cost and schedule control techniques throughout the project portfolio. The BCI concluded in December 2014, deploying over 100 cost and schedule management changes including best practices, tools, methods, training, and knowledge sharing. The new business approach has driven the portfolio to improved programmatic performance. The last eight launched GSFC missions have optimized cost, schedule, and technical performance on a sustained basis to deliver on time and within budget, returning funds in many cases. While not every future mission will boast such strong performance, improved cost and schedule tools, management practices, and ongoing comprehensive evaluations of program planning and control methods to refine and implement best practices will continue to provide a framework for sustained performance. This paper will describe the tools, techniques, and processes developed during the BCI and the utilization of collaborative content management tools to disseminate project planning and control techniques to ensure continuous collaboration and optimization of cost and schedule management in the future.

Knowledge-Based Scheduling of Arrival Aircraft in the Terminal Area

NASA Technical Reports Server (NTRS)

Krzeczowski, K. J.; Davis, T.; Erzberger, H.; Lev-Ram, Israel; Bergh, Christopher P.

1995-01-01

A knowledge based method for scheduling arrival aircraft in the terminal area has been implemented and tested in real time simulation. The scheduling system automatically sequences, assigns landing times, and assign runways to arrival aircraft by utilizing continuous updates of aircraft radar data and controller inputs. The scheduling algorithm is driven by a knowledge base which was obtained in over two thousand hours of controller-in-the-loop real time simulation. The knowledge base contains a series of hierarchical 'rules' and decision logic that examines both performance criteria, such as delay reductions, as well as workload reduction criteria, such as conflict avoidance. The objective of the algorithm is to devise an efficient plan to land the aircraft in a manner acceptable to the air traffic controllers. This paper describes the scheduling algorithms, gives examples of their use, and presents data regarding their potential benefits to the air traffic system.

Knowledge-based scheduling of arrival aircraft

NASA Technical Reports Server (NTRS)

Krzeczowski, K.; Davis, T.; Erzberger, H.; Lev-Ram, I.; Bergh, C.

1995-01-01

A knowledge-based method for scheduling arrival aircraft in the terminal area has been implemented and tested in real-time simulation. The scheduling system automatically sequences, assigns landing times, and assigns runways to arrival aircraft by utilizing continuous updates of aircraft radar data and controller inputs. The scheduling algorithms is driven by a knowledge base which was obtained in over two thousand hours of controller-in-the-loop real-time simulation. The knowledge base contains a series of hierarchical 'rules' and decision logic that examines both performance criteria, such as delay reduction, as well as workload reduction criteria, such as conflict avoidance. The objective of the algorithms is to devise an efficient plan to land the aircraft in a manner acceptable to the air traffic controllers. This paper will describe the scheduling algorithms, give examples of their use, and present data regarding their potential benefits to the air traffic system.

33 CFR 401.58 - Pleasure craft scheduling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Pleasure craft scheduling. 401.58... OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.58 Pleasure craft scheduling. (a) The transit of pleasure craft shall be scheduled by the traffic controller or the officer in...

75 FR 1814 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to cultivate marihuana for the National Institute on Drug Abuse for research...

75 FR 6062 - Manufacturer of Controlled Substances Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-05

... controlled substances listed in schedules I and II: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I Cocaine (9041) I The Institute will manufacture small quantities of cocaine and marihuana...

Wave scheduling - Decentralized scheduling of task forces in multicomputers

NASA Technical Reports Server (NTRS)

Van Tilborg, A. M.; Wittie, L. D.

1984-01-01

Decentralized operating systems that control large multicomputers need techniques to schedule competing parallel programs called task forces. Wave scheduling is a probabilistic technique that uses a hierarchical distributed virtual machine to schedule task forces by recursively subdividing and issuing wavefront-like commands to processing elements capable of executing individual tasks. Wave scheduling is highly resistant to processing element failures because it uses many distributed schedulers that dynamically assign scheduling responsibilities among themselves. The scheduling technique is trivially extensible as more processing elements join the host multicomputer. A simple model of scheduling cost is used by every scheduler node to distribute scheduling activity and minimize wasted processing capacity by using perceived workload to vary decentralized scheduling rules. At low to moderate levels of network activity, wave scheduling is only slightly less efficient than a central scheduler in its ability to direct processing elements to accomplish useful work.

KSC-97PC1276

NASA Image and Video Library

1997-08-22

Richard Spehalski, program manager of the Cassini mission, and Hamid Hassan, the European Space Agency Huygens project manager, stand in front of the Cassini spacecraft in the Payload Hazardous Servicing Facility (PHSF). The Cassini spacecraft is scheduled to launch on an Air Force Titan IV/Centaur launch vehicle on Oct. 6, 1997. It is destined to arrive at Saturn in July 2004, to study Saturn, its rings, moons and magnetic environment for a four-year period. The Cassini project is managed for NASA by the Jet Propulsion Laboratory in Pasadena, Calif

KSC-06pd0764

NASA Image and Video Library

2006-04-30

KENNEDY SPACE CENTER, FLA. - On Launch Complex 37 at Cape Canaveral Air Force Station in Florida, the GOES-N spacecraft is lowered toward the second stage of the Boeing Delta IV rocket for mating. GOES-N is the latest in a series of Geostationary Operational Environmental Satellites for NOAA and NASA, providing continuous monitoring necessary for intensive data analysis. GOES-N is scheduled to be launched May 18 in an hour-long window between 6:14 and 7:14 p.m. EDT. Photo credit: NASA/Charisse Nahser

Military Base Realignments and Closures. DOD Needs to Update Savings Estimates and Continue to Address Challenges in Consolidating Supply-Related Functions at Depot Maintenance Locations

DTIC Science & Technology

2009-07-01

Comments from the Department of Defense 33 Appendix IV GAO Contact and Staff Acknowledgments 36 Related GAO Products 37 Tables Table...work of the U.S. government and is not subject to copyright protection in the United States. The published product may be reproduced and distributed in...disrupting maintenance production schedules due to personnel transfers since the employees are already experienced in performing these jobs. DLA Has

VLBI2010: Networks and Observing Strategies

NASA Technical Reports Server (NTRS)

Petrachenko, Bill; Corey, Brian; Himwich, Ed; Ma, Chopo; Malkin, Zinovy; Niell, Arthur; Shaffer, David; Vandenberg, Nancy

2004-01-01

The Observing Strategies Sub-group of IVS's Working Group 3 has been tasked with producing a vision for the following aspects of geodetic VLBI: antenna-network structure and observing strategies; source strength/structure/distribution; frequency bands, RFI; and field system and scheduling. These are high level considerations that have far reaching impact since they significantly influence performance potential and also constrain requirements for a number of other \\VG3 sub-groups. The paper will present the status of the sub-group's work on these topics.

Why does Acute Postwhiplash Injury Pain Transform into Chronic Pain Multimodal Assessment of Risk Factors and Predictors of Pain Chronification

DTIC Science & Technology

2016-10-19

data acquisition. iii. We determined working procedures with the Technion genetic lab. iv. We exercised data transfer between our site and the MRI ... MRI protocols and training of the technical staff. viii. A meeting of the study investigators was held during the world pain conference in Japan in...participated in the study. 20 subjects had withdrawn their consent mainly due to MRI scanner availability and scheduling issues, or excluded from the

Characterization and Calibration of the 12-m Antenna in Warkworth, New Zealand

NASA Technical Reports Server (NTRS)

Gulyaev, Sergei; Natusch, Tim; Wilson, David

2010-01-01

The New Zealand 12-m antenna is scheduled to start participating in regular IVS VLBI sessions from the middle of 2010. Characterization procedures and results of calibration of the New Zealand 12- m radio telescope are presented, including the main reflector surface accuracy measurement, pointing model creation, and the system equivalent flux density (SEFD) determination in both S and X bands. Important issues of network connectivity, co-located geodetic systems, and the use of the antenna in education are also discussed.

75 FR 10313 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances... application by renewal to the Drug Enforcement Administration (DEA) to be registered as a bulk manufacturer of the basic classes of controlled substances listed in schedules I and II: Drug Schedule Gamma...

Stress in air traffic controllers : comparison of two air route traffic control centers on different shift rotation patterns.

DOT National Transportation Integrated Search

1975-01-01

Stress in 23 air traffic controllers (ATCS) at Atlanta Air Route Traffic Control Center (ATL) on the straight 5-day shift rotation schedule was compared with stress in 23 ATCS's on the 2-2-1 shift rotation schedule at Fort Worth Air Route Traffic Con...

LPV Modeling and Control for Active Flutter Suppression of a Smart Airfoil

NASA Technical Reports Server (NTRS)

Al-Hajjar, Ali M. H.; Al-Jiboory, Ali Khudhair; Swei, Sean Shan-Min; Zhu, Guoming

2018-01-01

In this paper, a novel technique of linear parameter varying (LPV) modeling and control of a smart airfoil for active flutter suppression is proposed, where the smart airfoil has a groove along its chord and contains a moving mass that is used to control the airfoil pitching and plunging motions. The new LPV modeling technique is proposed that uses mass position as a scheduling parameter to describe the physical constraint of the moving mass, in addition the hard constraint at the boundaries is realized by proper selection of the parameter varying function. Therefore, the position of the moving mass and the free stream airspeed are considered the scheduling parameters in the study. A state-feedback based LPV gain-scheduling controller with guaranteed H infinity performance is presented by utilizing the dynamics of the moving mass as scheduling parameter at a given airspeed. The numerical simulations demonstrate the effectiveness of the proposed LPV control architecture by significantly improving the performance while reducing the control effort.

Scheduled power tracking control of the wind-storage hybrid system based on the reinforcement learning theory

NASA Astrophysics Data System (ADS)

Li, Ze

2017-09-01

In allusion to the intermittency and uncertainty of the wind electricity, energy storage and wind generator are combined into a hybrid system to improve the controllability of the output power. A scheduled power tracking control method is proposed based on the reinforcement learning theory and Q-learning algorithm. In this method, the state space of the environment is formed with two key factors, i.e. the state of charge of the energy storage and the difference value between the actual wind power and scheduled power, the feasible action is the output power of the energy storage, and the corresponding immediate rewarding function is designed to reflect the rationality of the control action. By interacting with the environment and learning from the immediate reward, the optimal control strategy is gradually formed. After that, it could be applied to the scheduled power tracking control of the hybrid system. Finally, the rationality and validity of the method are verified through simulation examples.

A Baseline Load Schedule for the Manual Calibration of a Force Balance

NASA Technical Reports Server (NTRS)

Ulbrich, N.; Gisler, R.

2013-01-01

A baseline load schedule for the manual calibration of a force balance was developed that takes current capabilities at the NASA Ames Balance Calibration Laboratory into account. The load schedule consists of 18 load series with a total of 194 data points. It was designed to satisfy six requirements: (i) positive and negative loadings should be applied for each load component; (ii) at least three loadings should be applied between 0 % and 100 % load capacity; (iii) normal and side force loadings should be applied at the forward gage location, the aft gage location, and the balance moment center; (iv) the balance should be used in UP and DOWN orientation to get axial force loadings; (v) the constant normal and side force approaches should be used to get the rolling moment loadings; (vi) rolling moment loadings should be obtained for 0, 90, 180, and 270 degrees balance orientation. Three different approaches are also reviewed that may be used to independently estimate the natural zeros of the balance. These three approaches provide gage output differences that may be used to estimate the weight of both the metric and non-metric part of the balance. Manual calibration data of NASA s MK29A balance and machine calibration data of NASA s MC60D balance are used to illustrate and evaluate different aspects of the proposed baseline load schedule design.

75 FR 64745 - Manufacturer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... classes of controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to cultivate marihuana for the National Institute on Drug Abuse for...

75 FR 1812 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... of controlled substances listed in schedule II: Drug Schedule Phenylacetone (8501) II Coca Leaves... registration or re-registration to import crude opium, poppy straw, concentrate of poppy straw or coca leaves...

75 FR 75496 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... controlled substances listed in schedule I and II: Drug Schedule Marijuana (7360) I Tetrahydrocannabinols... customers for non- clinical, laboratory-based research only. In reference to drug code 7360 (Marijuana), the...

KSC-2013-3767

NASA Image and Video Library

2013-10-24

CAPE CANAVERAL, Fla. – Inside the Orion Test and Launch Control Center at NASA’s Kennedy Space Center in Florida, engineers monitor data for the first Exploration Flight Test 1, or EFT-1, power up test. NASA’s first-ever deep space craft, Orion, was powered on for the first time, marking a major milestone in the final year of preparations for flight. Orion’s avionics system was installed on the crew module and powered up for a series of systems tests. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

KSC-2013-3766

NASA Image and Video Library

2013-10-24

CAPE CANAVERAL, Fla. – Inside the Orion Test and Launch Control Center at NASA’s Kennedy Space Center in Florida, an engineer prepares for the first Exploration Flight Test 1, or EFT-1, power up test. NASA’s first-ever deep space craft, Orion, was powered on for the first time, marking a major milestone in the final year of preparations for flight. Orion’s avionics system was installed on the crew module and powered up for a series of systems tests. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

KSC-2013-3765

NASA Image and Video Library

2013-10-24

CAPE CANAVERAL, Fla. – Inside the Orion Test and Launch Control Center at NASA’s Kennedy Space Center in Florida, engineers prepare for the first Exploration Flight Test 1, or EFT-1, power up test. NASA’s first-ever deep space craft, Orion, was powered on for the first time, marking a major milestone in the final year of preparations for flight. Orion’s avionics system was installed on the crew module and powered up for a series of systems tests. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

KSC-2013-3763

NASA Image and Video Library

2013-10-24

CAPE CANAVERAL, Fla. – Inside the Orion Test and Launch Control Center at NASA’s Kennedy Space Center in Florida, engineers prepare for the first Exploration Flight Test 1, or EFT-1, power up test. NASA’s first-ever deep space craft, Orion, was powered on for the first time, marking a major milestone in the final year of preparations for flight. Orion’s avionics system was installed on the crew module and powered up for a series of systems tests. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

KSC-2013-3768

NASA Image and Video Library

2013-10-24

CAPE CANAVERAL, Fla. – Inside the Orion Test and Launch Control Center at NASA’s Kennedy Space Center in Florida, engineers monitor data during the first Exploration Flight Test 1, or EFT-1, power up test. NASA’s first-ever deep space craft, Orion, was powered on for the first time, marking a major milestone in the final year of preparations for flight. Orion’s avionics system was installed on the crew module and powered up for a series of systems tests. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

KSC-2013-3764

NASA Image and Video Library

2013-10-24

CAPE CANAVERAL, Fla. – Inside the Orion Test and Launch Control Center at NASA’s Kennedy Space Center in Florida, engineers prepare for the first Exploration Flight Test 1, or EFT-1, power up test. NASA’s first-ever deep space craft, Orion, was powered on for the first time, marking a major milestone in the final year of preparations for flight. Orion’s avionics system was installed on the crew module and powered up for a series of systems tests. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion, EFT-1, is scheduled to launch in 2014 atop a Delta IV rocket and in 2017 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

Physical Activity and Alcohol Use Disorders

PubMed Central

Lisha, Nadra E.; Sussman, Steve; FAPA, FAAHB; Leventhal, Adam M.

2013-01-01

Background Prior research has documented a counterintuitive positive association between physical activity and indices of alcohol consumption frequency and heaviness. Objectives To investigate whether this relation extends to alcohol use disorder and clarify whether this association is non-linear. Methods This is a cross-sectional, correlational population-based study of US adults (N = 34,653). The Alcohol Use Disorder and Associated Disabilities Interview Schedule was used to classify past-year DSM-IV alcohol use disorder and self-reported federal government-recommended weekly physical activity cutoffs. Results After statistically controlling for confounds, alcohol abuse but not dependence was associated with greater prevalence of physical activity. Number of alcohol use disorder symptoms exhibited a curvilinear relationship with meeting physical activity requirements, such that the positive association degraded with high symptom counts. Conclusion There is a positive association between physical activity and less severe forms of alcohol use disorder in US adults. More severe forms of alcohol use disorder are not associated with physical activity. PMID:22992050

Infusion volume control and calculation using metronome and drop counter based intravenous infusion therapy helper.

PubMed

Park, Kyungnam; Lee, Jangyoung; Kim, Soo-Young; Kim, Jinwoo; Kim, Insoo; Choi, Seung Pill; Jeong, Sikyung; Hong, Sungyoup

2013-06-01

This study assessed the method of fluid infusion control using an IntraVenous Infusion Controller (IVIC). Four methods of infusion control (dial flow controller, IV set without correction, IV set with correction and IVIC correction) were used to measure the volume of each technique at two infusion rates. The infused fluid volume with a dial flow controller was significantly larger than other methods. The infused fluid volume was significantly smaller with an IV set without correction over time. Regarding the concordance correlation coefficient (CCC) of infused fluid volume in relation to a target volume, IVIC correction was shown to have the highest level of agreement. The flow rate measured in check mode showed a good agreement with the volume of collected fluid after passing through the IV system. Thus, an IVIC could assist in providing an accurate infusion control. © 2013 Wiley Publishing Asia Pty Ltd.

KSC-2013-2882

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida. Pointing at thermal protection system tiles is Jules Schneider, Lockheed Martin senior manager. At right, in the blue suit, is Bernardo Patti, ESA manager of International Space Station Operations. Standing next to Patti is Nico Dettman, ESA Space Transportation Department director. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-2918

NASA Image and Video Library

2013-06-27

CAPE CANAVERAL, Fla. – Inside the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, members of the media receive an on activities in NASA’s Ground Systems Development and Operations, or GSDO, Program, Space Launch System and Orion crew module for Exploration Test Flight 1. Speaking to the media is Scott Wilson, manager of Orion Production Operations at Kennedy. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-2923

NASA Image and Video Library

2013-06-27

CAPE CANAVERAL, Fla. – Inside the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, members of the media receive an on activities in NASA’s Ground Systems Development and Operations, or GSDO, Program, Space Launch System and Orion crew module for Exploration Test Flight 1. Speaking to the media is Jeremy Parsons, chief of the GSDO Operations Integration Office at Kennedy. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-2922

NASA Image and Video Library

2013-06-27

CAPE CANAVERAL, Fla. – Inside the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, members of the media receive an on activities in NASA’s Ground Systems Development and Operations, or GSDO, Program, Space Launch System and Orion crew module for Exploration Test Flight 1. Speaking to the media is Jeremy Parsons, chief of the GSDO Operations Integration Office at Kennedy. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Comparison of Effectiveness of Betamethasone gel Applied to the Tracheal Tube and IV Dexamethasone on Postoperative Sore Throat: A Randomized Controlled Trial

PubMed Central

Tabari, Masoomeh; Soltani, Ghasem; Zirak, Nahid; Alipour, Mohammad; Khazaeni, Kamran

2013-01-01

Introduction: Postoperative sore throat is a common complaint in patients with endotracheal intubation and has potentially dangerous complications. This randomized controlled trial study investigated the incidence of postoperative sore throat after general anesthesia when betamethasone gel is applied to a tracheal tube compared with when IV dexamethasone is prescribed. Materials and Methods: Two hundred and twenty five American Society of Anesthesiologist (ASA)-class I and II patients undergoing elective abdominal surgery with tracheal intubation were randomly divided into three groups: betamethasone gel, intravenous (IV) dexamethasone, and control groups. In the post-anesthesia care unit, a blinded anesthesiologist interviewed all patients regarding postoperative sore throat at 1,6, and 24 hours after surgery. Results: The incidence of sore throat was significantly lower in the betamethasone gel group compared with the IV dexamethasone and control groups, 1, 6, and 24 hours after surgery. In the first day after surgery 10.7% of the betamethasone group had sore throat whereas 26.7% of the IV dexamethasone group and 30.7% of the control group had sore throat. Bucking before extubation was observed in 14(18.4%), 8(10.4%), and 9(12.2%) patients, in the IV dexamethasone, betamethasone gel, and control group, respectively. Conclusion: We concluded that wide spread application of betamethasone gel over tracheal tubes effectively mitigates postoperative sore throat, compared with IV dexamethasone application. PMID:24303443

40 CFR 52.720 - Identification of plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Illinois Pollution Control Board Regulations, Chapter 2, Parts I, II and III were submitted May 4, 1972, by the Governor. (3) A document describing the role of the Chicago Department of Environmental Control...) Compliance schedules submitted on March 13, 1973, by the Pollution Control Board. (6) Compliance schedules...

75 FR 10312 - Importer of Controlled Substances Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances Notice of... by renewal to the Drug Enforcement Administration (DEA) to be registered as an importer of the basic classes of controlled substances listed in schedule II: Drug Schedule Opium, raw (9600) II Poppy Straw...

40 CFR 52.720 - Identification of plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Illinois Pollution Control Board Regulations, Chapter 2, Parts I, II and III were submitted May 4, 1972, by the Governor. (3) A document describing the role of the Chicago Department of Environmental Control...) Compliance schedules submitted on March 13, 1973, by the Pollution Control Board. (6) Compliance schedules...

Schedules of Controlled Substances: Placement of Three Synthetic Phenethylamines Into Schedule I. Final rule.

PubMed

2016-09-27

With the issuance of this final rule, the Administrator of the Drug Enforcement Administration places three synthetic phenethylamines: 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N- (2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B- NBOMe; 2C-B-NBOMe; 25B; Cimbi-36), including their optical, positional, and geometric isomers, salts and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act which requires that such actions be made on the record after opportunity for a hearing through formal rulemaking. This action continues the application of the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle 25I-NBOMe, 25C-NBOMe, or 25B-NBOMe.

40 CFR Appendix K to Subpart A of... - Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled Substances K Appendix K to Subpart A of...) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. K Appendix K to...

40 CFR Appendix K to Subpart A of... - Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled Substances K Appendix K to Subpart A of...) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. K Appendix K to...

40 CFR Appendix K to Subpart A of... - Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled Substances K Appendix K to Subpart A of...) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. K Appendix K to...

40 CFR Appendix K to Subpart A of... - Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled Substances K Appendix K To Subpart A Of...) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. K Appendix K To...

40 CFR Appendix K to Subpart A of... - Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Commodity Codes From the Harmonized Tariff Schedule for Controlled Substances and Used Controlled Substances K Appendix K to Subpart A of...) PROTECTION OF STRATOSPHERIC OZONE Production and Consumption Controls Pt. 82, Subpt. A, App. K Appendix K to...

Control over the Scheduling of Simulated Office Work Reduces the Impact of Workload on Mental Fatigue and Task Performance

ERIC Educational Resources Information Center

Hockey, G. Robert J.; Earle, Fiona

2006-01-01

Two experiments tested the hypothesis that task-induced mental fatigue is moderated by control over work scheduling. Participants worked for 2 hr on simulated office work, with control manipulated by a yoking procedure. Matched participants were assigned to conditions of either high control (HC) or low control (LC). HC participants decided their…

Schedules of controlled substances: temporary placement of three synthetic phenethylamines into Schedule I. Final order.

PubMed

2013-11-15

The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule three synthetic phenethylamines into the Controlled Substances Act (CSA) pursuant to the temporary scheduling provisions of 21 U.S.C. 811(h). The substances are 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C; Cimbi-82), and 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe; 2C-B-NBOMe; 25B; Cimbi-36) [hereinafter 25I-NBOMe, 25C-NBOMe, and 25B-NBOMe]. This action is based on a finding by the Deputy Administrator that the placement of these synthetic phenethylamines and their optical, positional, and geometric isomers, salts and salts of isomers in schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, dispense, import, export, engage in research, conduct instructional activities, and possess), or propose to handle these synthetic phenethylamines.

CHMICA and MDMB-FUBINACA) Into Schedule I. Notice of Intent.

PubMed

2016-12-21

The Administrator of the Drug Enforcement Administration is issuing this notice of intent to temporarily schedule six synthetic cannabinoids: methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]; methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]; N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]; methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA] and methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA], into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act (CSA). This action is based on a finding by the Administrator that the placement of these synthetic cannabinoids into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. Any final order will impose the administrative, civil, and criminal sanctions and regulatory controls applicable to schedule I substances under the Controlled Substances Act on the manufacture, distribution, possession, importation, exportation of, and research and conduct with, instructional activities of these synthetic cannabinoids.

Transference effects of prior non-contingent reinforcement on the acquisition of temporal control on fixed-interval schedules.

PubMed

López, Florente; Menez, Marina

2012-07-01

In two experiments we examined the influence of response and time factors on the speed of acquisition of temporal control on FI schedules. In Experiment 1, prior exposure to FT accelerated the development of temporal control on FI schedules of the same temporal value. It was also found that the slower acquisition on FI with prior RT was similar to that of rats with prior standard training. In Experiment 2, prior exposure to FT accelerated the development of temporal control on a FI schedule with a threefold increase in temporal value. Additionally, it was found that with prior FI 30s training, acquisition of temporal control on FI 90s was even faster than with prior FT 30s. Measures of head-entries into the feeder along the experiments indicated that temporal control was already developed during the periodic but not during the non-periodic histories and that this control transferred to lever press during FI testing phase. Copyright © 2012 Elsevier B.V. All rights reserved.

Oxaliplatin in combination with protracted-infusion fluorouracil and radiation: report of a clinical trial for patients with esophageal cancer.

PubMed

Khushalani, Nikhil I; Leichman, Cynthia Gail; Proulx, Gary; Nava, Hector; Bodnar, Lisa; Klippenstein, Donald; Litwin, Alan; Smith, Judy; Nava, Enriqueta; Pendyala, Lakshmi; Smith, Patrick; Greco, William; Berdzik, Joanne; Douglass, Harold; Leichman, Lawrence

2002-06-15

To identify a dose and schedule of oxaliplatin (OXP) to be safely administered in combination with protracted-infusion (PI) fluorouracil (5-FU) and external-beam radiation therapy (XRT) for patients with primary esophageal carcinoma (EC). Eligibility included therapeutically naïve EC patients with clinical disease stages II, III, or IV. Initial doses and schedules for cycle 1 consisted of OXP 85 mg/m(2) on days 1, 15, and 29; PI 5-FU 180 mg/m(2) for 24 hours for 35 days; and XRT 1.8 Gy in 28 fractions starting on day 8. At completion of cycle 1, eligible patients could undergo an operation or begin cycle 2 without XRT. Postoperative patients were eligible for cycle 2. Stage IV patients were allowed three cycles in the absence of disease progression. OXP and 5-FU increases were based on dose-limiting toxicity (DLT) encountered in cohorts of three consecutive patients. Thirty-eight eligible patients received therapy: 22 noninvasively staged as IV and 16 noninvasively staged as II and III. Thirty-six patients completed cycle 1, 29 patients started cycle 2, and 24 patients completed cycle 2. The combined-modality therapy was well tolerated, but DLT prevented OXP and 5-FU escalation. No grade 4 hematologic toxicity was noted. Eleven grade 3 and two grade 4 clinical toxicities were noted in eight patients. After cycle 1, 29 patients (81%) had no cancer in the esophageal mucosa. Thirteen patients underwent an operation with intent to resect the esophagus; five patients (38%) exhibited pathologic complete responses. OXP 85 mg/m(2) on days 1, 15, and 29 administered with PI 5-FU and XRT is safe, tolerable, and seems effective against primary EC. The role of OXP in multimodality regimens against EC deserves further evaluation.

Effects of maneuver dynamics on drag polars of the X-29A forward-swept-wing aircraft with automatic wing camber control

NASA Technical Reports Server (NTRS)

Hicks, John W.; Moulton, Bryan J.

1988-01-01

The camber control loop of the X-29A FSW aircraft was designed to furnish the optimum L/D for trimmed, stabilized flight. A marked difference was noted between automatic wing camber control loop behavior in dynamic maneuvers and in stabilized flight conditions, which in turn affected subsonic aerodynamic performance. The degree of drag level increase was a direct function of maneuver rate. Attention is given to the aircraft flight drag polar effects of maneuver dynamics in light of wing camber control loop schedule. The effect of changing camber scheduling to better track the optimum automatic camber control L/D schedule is discussed.

78 FR 62500 - Schedules of Controlled Substances: Placement of Perampanel into Schedule III

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... of the Controlled Substances Act (CSA). This proposed action is based on a recommendation from the... (manufacture, distribute, dispense, import, export, engage in research, conduct instructional activities, and..., scientific, research, and industrial needs of the United States. Controlled substances have the potential for...

Predictors of parent-child agreement on child anxiety diagnoses on the ADIS-IV-C/P.

PubMed

Hamblin, Rebecca J; Salloum, Alison; Andel, Ross; Nadeau, Joshua M; McBride, Nicole M; Lewin, Adam B; Storch, Eric A

2016-11-30

Diagnostic agreement between parents' and children's reports on children's anxiety problems is notoriously poor; however, very few investigations have examined specific predictors of inter-rater agreement on child anxiety diagnoses. This study examined predictors of categories of parent and child diagnostic endorsement on the Anxiety Disorders Interview Schedule for Children-IV. One hundred eight children (ages 7-13) and their parents completed structured diagnostic interviews for non-OCD/PTSD anxiety diagnoses and paper and pencil measures of functioning and impairment in a variety of domains. Parent-child agreement was statistically significant for social phobia and separation anxiety disorder, but was overall poor for all anxiety diagnoses. Externalizing disorder status, family accommodation frequency, and child rated impairment in various domains differentially predicted informant discrepancies for different anxiety disorders. These data are among the first to suggest variables that may explain parent-child concordance. Copyright © 2016. Published by Elsevier Ireland Ltd.

The Dresden Predictor Study of anxiety and depression: objectives, design, and methods.

PubMed

Trumpf, Julia; Vriends, Noortje; Meyer, Andrea H; Becker, Eni S; Neumer, Simon-Peter; Margraf, Jürgen

2010-09-01

The present report describes the objectives, design, and methods of the Dresden Predictor Study (DPS) of anxiety and depression, a prospective epidemiological study investigating anxiety disorders and depression in 3,065 young German women (18-25 years of age). The DPS consists of a baseline and one follow-up investigation separated by approximately 17 months. At both time points, respondents were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) using an extended German version of the Anxiety Disorders Interview Schedule (ADIS-IV-L). In addition to diagnostic assessment, respondents completed a battery of self-report questionnaires that provided detailed information about potential predictors of disorders and a comprehensive dimensional assessment of psychopathology. Results on both response bias in the baseline investigation and effects of dropout at follow-up are presented, and strengths and limitations of the study design are discussed.

Toxic adenoma of the thyroid gland and Wolff-Parkinson-White syndrome

PubMed Central

Naço, M; Çeliku, E; Llukaçaj, A; Shehaj, J; Kameniku, R

2009-01-01

We report the case of a 17-year-old girl with toxic adenoma scheduled for surgery right lobectomy and isthmectomy of thyroid gland. During the examination before surgery, patient was diagnosed for the first time as having with Wolff – Parkinson – White (WPW) syndrome. In the operating room, after the induction of anesthesia, the electrocardiogram showed wide QRS complex tachycardia with a rate of 180 beats/min, which was diagnosed as paroxysmal supraventricular tachycardia. The patient was treated immediately with antiarrhythmic drugs: adenosine iv three times (at doses of 6 mg, 12mg, 12mg bolus) and esmolol iv twice (at doses 28.5 mg). This approach resulted in disappearance of the delta wave and tachycardia for the whole surgery period. In this case report we discuss the role of induction of anesthesia and presence of toxic adenoma in a patient with WPW. PMID:19561784

Food-deprivation effects on punished schedule-induced drinking in rats.

PubMed Central

Lamas, E; Pellón, R

1995-01-01

Food-deprived rats (at 80% of their free-feeding weights) were exposed to a fixed-time 60-s schedule of food-pellet presentation and developed schedule-induced drinking. Lick-dependent signaled delays (10 s) to food presentation led to decreased drinking, which recovered when the signaled delays were discontinued. A major effect of this punishment contingency was to increase the proportion of interpellet intervals without any licks. The drinking of yoked control rats, which received food at the same times as those exposed to the signaled delay contingency (masters), was not consistently reduced. When food-deprivation level was changed to 90%, all master and yoked control rats showed decreases in punished or unpunished schedule-induced drinking. When the body weights were reduced to 70%, most master rats increased punished behavior to levels similar to those of unpunished drinking. This effect was not observed for yoked controls. Therefore, body-weight loss increased the resistance of schedule-induced drinking to reductions by punishment. Food-deprivation effects on punished schedule-induced drinking are similar to their effects on food-maintained lever pressing. This dependency of punishment on food-deprivation level supports the view that schedule-induced drinking can be modified by the same variables that affect operant behavior in general. PMID:7622981

75 FR 36680 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... requests for hearings on applications to import narcotic raw material are not appropriate. As noted in a... as an importer of the basic classes of controlled substances listed in schedule II: Drug Schedule Raw...

Changing Workplaces to Reduce Work-Family Conflict: Schedule Control in a White-Collar Organization

PubMed Central

Kelly, Erin L.; Moen, Phyllis; Tranby, Eric

2011-01-01

Work-family conflicts are common and consequential for employees, their families, and work organizations. Can workplaces be changed to reduce work-family conflict? Previous research has not been able to assess whether workplace policies or initiatives succeed in reducing work-family conflict or increasing work-family fit. Using longitudinal data collected from 608 employees of a white-collar organization before and after a workplace initiative was implemented, we investigate whether the initiative affects work-family conflict and fit, whether schedule control mediates these effects, and whether work demands, including long hours, moderate the initiative’s effects on work-family outcomes. Analyses clearly demonstrate that the workplace initiative positively affects the work-family interface, primarily by increasing employees’ schedule control. This study points to the importance of schedule control for our understanding of job quality and for management policies and practices. PMID:21580799

Efficient operation scheduling for adsorption chillers using predictive optimization-based control methods

NASA Astrophysics Data System (ADS)

Bürger, Adrian; Sawant, Parantapa; Bohlayer, Markus; Altmann-Dieses, Angelika; Braun, Marco; Diehl, Moritz

2017-10-01

Within this work, the benefits of using predictive control methods for the operation of Adsorption Cooling Machines (ACMs) are shown on a simulation study. Since the internal control decisions of series-manufactured ACMs often cannot be influenced, the work focuses on optimized scheduling of an ACM considering its internal functioning as well as forecasts for load and driving energy occurrence. For illustration, an assumed solar thermal climate system is introduced and a system model suitable for use within gradient-based optimization methods is developed. The results of a system simulation using a conventional scheme for ACM scheduling are compared to the results of a predictive, optimization-based scheduling approach for the same exemplary scenario of load and driving energy occurrence. The benefits of the latter approach are shown and future actions for application of these methods for system control are addressed.

Changing Workplaces to Reduce Work-Family Conflict: Schedule Control in a White-Collar Organization.

PubMed

Kelly, Erin L; Moen, Phyllis; Tranby, Eric

2011-04-01

Work-family conflicts are common and consequential for employees, their families, and work organizations. Can workplaces be changed to reduce work-family conflict? Previous research has not been able to assess whether workplace policies or initiatives succeed in reducing work-family conflict or increasing work-family fit. Using longitudinal data collected from 608 employees of a white-collar organization before and after a workplace initiative was implemented, we investigate whether the initiative affects work-family conflict and fit, whether schedule control mediates these effects, and whether work demands, including long hours, moderate the initiative's effects on work-family outcomes. Analyses clearly demonstrate that the workplace initiative positively affects the work-family interface, primarily by increasing employees' schedule control. This study points to the importance of schedule control for our understanding of job quality and for management policies and practices.

Backup control airstart performance on a digital electronic engine control-equipped F100-engine

NASA Technical Reports Server (NTRS)

Johnson, J. B.

1984-01-01

The air start capability of a backup control (BUC) was tested for a digital electronic engine control (DEEC) equipped F100 engine, which was installed in an F-15 aircraft. Two air start schedules were tested. Using the group 1 start schedule, based on a 40 sec timer, an air speed of 300 knots was required to ensure successful 40 and 25% BUC mode spooldown airstarts. If core rotor speed (N2) was less than 40% a stall would occur when the start bleed closed, 40 sec after initiation of the air start. All jet fuel starter (JFS) assisted air starts were successful with the group 1 start schedule. For the group 2 schedule, the time between pressurization and start bleed closure ranged between 50 sec and 72 sec. Idle rps was lower than the desired 65% for air starts at higher altitudes and lower air speeds.

Robust control for spacecraft rendezvous system with actuator unsymmetrical saturation: a gain scheduling approach

NASA Astrophysics Data System (ADS)

Wang, Qian; Xue, Anke

2018-06-01

This paper has proposed a robust control for the spacecraft rendezvous system by considering the parameter uncertainties and actuator unsymmetrical saturation based on the discrete gain scheduling approach. By changing of variables, we transform the actuator unsymmetrical saturation control problem into a symmetrical one. The main advantage of the proposed method is improving the dynamic performance of the closed-loop system with a region of attraction as large as possible. By the Lyapunov approach and the scheduling technology, the existence conditions for the admissible controller are formulated in the form of linear matrix inequalities. The numerical simulation illustrates the effectiveness of the proposed method.

Effects of humeral intraosseous versus intravenous epinephrine on pharmacokinetics and return of spontaneous circulation in a porcine cardiac arrest model: A randomized control trial.

PubMed

Johnson, Don; Garcia-Blanco, Jose; Burgert, James; Fulton, Lawrence; Kadilak, Patrick; Perry, Katherine; Burke, Jeffrey

2015-09-01

Cardiopulmonary Resuscitation (CPR), defibrillation, and epinephrine administration are pillars of advanced cardiac life support (ACLS). Intraosseous (IO) access is an alternative route for epinephrine administration when intravenous (IV) access is unobtainable. Previous studies indicate the pharmacokinetics of epinephrine administration via IO and IV routes differ, but it is not known if the difference influences return of spontaneous circulation (ROSC). The purpose of this prospective, experimental study was to determine the effects of humeral IO (HIO) and IV epinephrine administration during cardiac arrest on pharmacokinetics, ROSC, and odds of survival. Swine (N = 21) were randomized into 3 groups: humeral IO (HIO), peripheral IV (IV) and CPR/defibrillation control. Cardiac arrest was induced under general anesthesia. The swine remained in arrest for 2 min without intervention. Chest compressions were initiated and continued for 2 min. Epinephrine was administered and serial blood samples collected for pharmacokinetic analysis over 4 min. Defibrillation and epinephrine administration proceeded according to ACLS guidelines continuing for 20 min or until ROSC. Seven HIO swine, 4 IV swine, and no control swine had ROSC. There were no significant differences in ROSC, maximum concentration; except at 30 s, and time-to-concentration-maximum between the HIO and IV groups. Significant differences existed between the experimental groups and the control. The HIO delivers a higher concentration of epinephrine than the IV route at 30 s which may be a survival advantage. Clinicians may consider using the IO route to administer epinephrine during CA when there is no preexisting IV access or when IV access is unobtainable.

Effects of humeral intraosseous versus intravenous epinephrine on pharmacokinetics and return of spontaneous circulation in a porcine cardiac arrest model: A randomized control trial

PubMed Central

Johnson, Don; Garcia-Blanco, Jose; Burgert, James; Fulton, Lawrence; Kadilak, Patrick; Perry, Katherine; Burke, Jeffrey

2015-01-01

Cardiopulmonary Resuscitation (CPR), defibrillation, and epinephrine administration are pillars of advanced cardiac life support (ACLS). Intraosseous (IO) access is an alternative route for epinephrine administration when intravenous (IV) access is unobtainable. Previous studies indicate the pharmacokinetics of epinephrine administration via IO and IV routes differ, but it is not known if the difference influences return of spontaneous circulation (ROSC). The purpose of this prospective, experimental study was to determine the effects of humeral IO (HIO) and IV epinephrine administration during cardiac arrest on pharmacokinetics, ROSC, and odds of survival. Swine (N = 21) were randomized into 3 groups: humeral IO (HIO), peripheral IV (IV) and CPR/defibrillation control. Cardiac arrest was induced under general anesthesia. The swine remained in arrest for 2 min without intervention. Chest compressions were initiated and continued for 2 min. Epinephrine was administered and serial blood samples collected for pharmacokinetic analysis over 4 min. Defibrillation and epinephrine administration proceeded according to ACLS guidelines continuing for 20 min or until ROSC. Seven HIO swine, 4 IV swine, and no control swine had ROSC. There were no significant differences in ROSC, maximum concentration; except at 30 s, and time-to-concentration-maximum between the HIO and IV groups. Significant differences existed between the experimental groups and the control. The HIO delivers a higher concentration of epinephrine than the IV route at 30 s which may be a survival advantage. Clinicians may consider using the IO route to administer epinephrine during CA when there is no preexisting IV access or when IV access is unobtainable. PMID:26468375

Clean air act and acid precipitation receiving increased attention

NASA Astrophysics Data System (ADS)

Burns, Douglas A.; Lawrence, Gregory B.; Murdoch, Peter S.

In 1990 the U.S. Congress passed Title IV of the Clean Air Act Amendments, which was intended to reduce the adverse effects of acid deposition by reducing emissions of the acid precursors,sulfur dioxide (SO2) and nitrogen oxides (Nox). Passage of Title IV was a response to the findings of a decade of research performed in large part through the National Acid Precipitation Assessment Program (NAPAP), which concluded that acid deposition posed a current and future threat to vulnerable forest and aquatic ecosystems [NAPAP, 1991].Now,with reauthorization of the 1990 Clean Air Act Amendments scheduled for 2000, Congress is considering several bills that would further reduce emissions to ensure the restoration of damaged ecosystems. Title IV requires a 10 million ton per year reduction in SO2 emissions below 1980 levels by 2010 and establishes a national cap of 8.95 million tons per year on utility emissions by 2010. Atmospheric sulfur deposition began to decline in the late 1970s as a result of energy conservation and provisions of the Clean Air Act of 1980. Since implementation of Phase I of Title IV in 1995, SO2 emissions have dropped from more than 20 million tons per year in the early 1990s to 18.3 million tons in 1995 [NAPAP, 1998].Consequently, reductions in atmospheric sulfur deposition have accelerated throughout the United States since 1995.

A multicenter phase II study of Q3 week or weekly paclitaxel in combination with bevacizumab for the treatment of metastatic or unresectable angiosarcoma.

PubMed

Bui, Nam; Kamat, Nikhil; Ravi, Vinod; Chawla, Sant; Lohman, Marti; Ganjoo, Kristen N

2018-01-01

Paclitaxel (P) and bevacizumab (B) are agents that provide clinical benefit in advanced angiosarcoma (AS). The objective of this study was to assess the efficacy and safety of P-B in two different scheduled regimens. Patients were to receive P 200mg/m2 IV with B 15mg/kg IV every 21 days (Regimen A) or P 90mg/m2 IV weekly D1, 8, 15 with B 15mg/kg IV D1 of a 28 day cycle (Regimen B) x6 cycles. Maintenance B followed at a dose of 15 mg/kg intravenously once every 21 days. The primary end point was 4 month non-progression rate (NPR). A total of 16 patients were enrolled. 4 month NPR was 62.5% with median overall survival 16 months and median progression free survival 5.06 months. 11 patients made it to cycle 3 and were evaluable for response with 1 CR (9%), 4 PR (36%), 2 SD (18%), and 6 PD (36%). There were ten grade 3 toxicities and four grade 4 toxicities. The breakdown between the two regimens revealed comparable efficacy and safety. Paclitaxel and Bevacizumab is an active regimen in angiosarcoma. Q3 week and weekly paclitaxel appear similar in efficacy and safety.

A controlled genetic algorithm by fuzzy logic and belief functions for job-shop scheduling.

PubMed

Hajri, S; Liouane, N; Hammadi, S; Borne, P

2000-01-01

Most scheduling problems are highly complex combinatorial problems. However, stochastic methods such as genetic algorithm yield good solutions. In this paper, we present a controlled genetic algorithm (CGA) based on fuzzy logic and belief functions to solve job-shop scheduling problems. For better performance, we propose an efficient representational scheme, heuristic rules for creating the initial population, and a new methodology for mixing and computing genetic operator probabilities.

Range Scheduling Aid (RSA)

NASA Technical Reports Server (NTRS)

Logan, J. R.; Pulvermacher, M. K.

1991-01-01

Range Scheduling Aid (RSA) is presented in the form of the viewgraphs. The following subject areas are covered: satellite control network; current and new approaches to range scheduling; MITRE tasking; RSA features; RSA display; constraint based analytic capability; RSA architecture; and RSA benefits.

Nosologic Comparisons of DSM-IV and DSM-5 Alcohol and Drug Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III.

PubMed

Goldstein, Risë B; Chou, S Patricia; Smith, Sharon M; Jung, Jeesun; Zhang, Haitao; Saha, Tulshi D; Pickering, Roger P; Ruan, W June; Huang, Boji; Grant, Bridget F

2015-05-01

The purpose of this study was to examine prevalences and concordances between Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), and Fifth Edition (DSM-5) substance use disorders (SUDs) in a newly completed U.S. epidemiologic survey. The National Epidemiologic Survey on Alcohol and Related Conditions-III surveyed 36,309 civilian, noninstitutionalized adults. SUDs were assessed using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-5. Concordances between DSM-IV and DSM-5 disorders were assessed using kappa statistics. Prevalences of past-year substance-specific DSM-5 disorders (2+ criteria) were modestly higher than those of DSM-IV dependence and abuse combined for alcohol, sedatives/tranquilizers, opioids, and heroin, but lower for cannabis, cocaine, and stimulants. Lifetime prevalences were lower under DSM-5. Prevalences were similar between moderate to severe (4+ criteria) DSM-5 disorders and dependence, whereas prevalences of DSM-5 disorders at 3+ criteria (DSM-5 [3+]) were higher, particularly for cannabis. Past-year concordances were excellent for DSM-IV dependence and abuse combined versus any DSM-5 and DSM-IV dependence versus DSM-5 moderate to severe disorders; lifetime concordances were fair to excellent. Past-year concordances between DSM-IV and DSM-5 (3+) were generally similar to or modestly higher than those with any DSM-5 disorder; lifetime concordances were mostly lower. Findings are consistent with those informing the development of DSM-5. Future research should examine differences in patterns between past-year and lifetime disorders, particularly for cannabis. Other questions warranting investigation include whether different combinations of the same numbers of criteria carry different clinical or nosologic implications, whether changes innosology yield changes in treatment demand, and whether changes in characteristics of individuals with DSM-5 SUDs dictate modifications to screening and intervention.

System control of an autonomous planetary mobile spacecraft

NASA Technical Reports Server (NTRS)

Dias, William C.; Zimmerman, Barbara A.

1990-01-01

The goal is to suggest the scheduling and control functions necessary for accomplishing mission objectives of a fairly autonomous interplanetary mobile spacecraft, while maximizing reliability. Goals are to provide an extensible, reliable system conservative in its use of on-board resources, while getting full value from subsystem autonomy, and avoiding the lure of ground micromanagement. A functional layout consisting of four basic elements is proposed: GROUND and SYSTEM EXECUTIVE system functions and RESOURCE CONTROL and ACTIVITY MANAGER subsystem functions. The system executive includes six subfunctions: SYSTEM MANAGER, SYSTEM FAULT PROTECTION, PLANNER, SCHEDULE ADAPTER, EVENT MONITOR and RESOURCE MONITOR. The full configuration is needed for autonomous operation on Moon or Mars, whereas a reduced version without the planning, schedule adaption and event monitoring functions could be appropriate for lower-autonomy use on the Moon. An implementation concept is suggested which is conservative in use of system resources and consists of modules combined with a network communications fabric. A language concept termed a scheduling calculus for rapidly performing essential on-board schedule adaption functions is introduced.

The Associate Principal Astronomer for AI Management of Automatic Telescopes

NASA Technical Reports Server (NTRS)

Henry, Gregory W.

1998-01-01

This research program in scheduling and management of automatic telescopes had the following objectives: 1. To field test the 1993 Automatic Telescope Instruction Set (ATIS93) programming language, which was specifically developed to allow real-time control of an automatic telescope via an artificial intelligence scheduler running on a remote computer. 2. To develop and test the procedures for two-way communication between a telescope controller and remote scheduler via the Internet. 3. To test various concepts in Al scheduling being developed at NASA Ames Research Center on an automatic telescope operated by Tennessee State University at the Fairborn Observatory site in southern Arizona. and 4. To develop a prototype software package, dubbed the Associate Principal Astronomer, for the efficient scheduling and management of automatic telescopes.

77 FR 39737 - Controlled Substances: Proposed Adjustment to the Aggregate Production Quotas for 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... aggregate production quotas for some schedule I and II controlled substances, expressed in grams of.... [750,000 grams of levo-desoxyephedrine for use in a non-controlled, non-prescription product; 2,331,000 grams for methamphetamine mostly for conversion to a schedule III product; and 49,000 grams for...

International VLBI Service for Geodesy and Astrometry. Delivering high-quality products and embarking on observations of the next generation

NASA Astrophysics Data System (ADS)

Nothnagel, A.; Artz, T.; Behrend, D.; Malkin, Z.

2017-07-01

The International VLBI Service for Geodesy and Astrometry (IVS) regularly produces high-quality Earth orientation parameters from observing sessions employing extensive networks or individual baselines. The master schedule is designed according to the telescope days committed by the stations and by the need for dense sampling of the Earth orientation parameters (EOP). In the pre-2011 era, the network constellations with their number of telescopes participating were limited by the playback and baseline capabilities of the hardware (Mark4) correlators. This limitation was overcome by the advent of software correlators, which can now accommodate many more playback units in a flexible configuration. In this paper, we describe the current operations of the IVS with special emphasis on the quality of the polar motion results since these are the only EOP components which can be validated against independent benchmarks. The polar motion results provided by the IVS have improved continuously over the years, now providing an agreement with IGS results at the level of 20-25 μas in a WRMS sense. At the end of the paper, an outlook is given for the realization of the VLBI Global Observing System.

Beam dynamics and expected performance of Sweden's new storage-ring light source: MAX IV

NASA Astrophysics Data System (ADS)

Leemann, S. C.; Andersson, Å.; Eriksson, M.; Lindgren, L.-J.; Wallén, E.; Bengtsson, J.; Streun, A.

2009-12-01

MAX IV will be Sweden’s next-generation high-performance synchrotron radiation source. The project has recently been granted funding and construction is scheduled to begin in 2010. User operation for a broad and international user community should commence in 2015. The facility is comprised of two storage rings optimized for different wavelength ranges, a linac-based short-pulse facility and a free-electron laser for the production of coherent radiation. The main radiation source of MAX IV will be a 528 m ultralow emittance storage ring operated at 3 GeV for the generation of high-brightness hard x rays. This storage ring was designed to meet the requirements of state-of-the-art insertion devices which will be installed in nineteen 5 m long dispersion-free straight sections. The storage ring is based on a novel multibend achromat design delivering an unprecedented horizontal bare lattice emittance of 0.33 nm rad and a vertical emittance below the 8 pm rad diffraction limit for 1 Å radiation. In this paper we present the beam dynamics considerations behind this storage-ring design and detail its expected unique performance.

Decision-theoretic control of EUVE telescope scheduling

NASA Technical Reports Server (NTRS)

Hansson, Othar; Mayer, Andrew

1993-01-01

This paper describes a decision theoretic scheduler (DTS) designed to employ state-of-the-art probabilistic inference technology to speed the search for efficient solutions to constraint-satisfaction problems. Our approach involves assessing the performance of heuristic control strategies that are normally hard-coded into scheduling systems and using probabilistic inference to aggregate this information in light of the features of a given problem. The Bayesian Problem-Solver (BPS) introduced a similar approach to solving single agent and adversarial graph search patterns yielding orders-of-magnitude improvement over traditional techniques. Initial efforts suggest that similar improvements will be realizable when applied to typical constraint-satisfaction scheduling problems.

A multi-group and preemptable scheduling of cloud resource based on HTCondor

NASA Astrophysics Data System (ADS)

Jiang, Xiaowei; Zou, Jiaheng; Cheng, Yaodong; Shi, Jingyan

2017-10-01

Due to the features of virtual machine-flexibility, easy controlling and various system environments, more and more fields utilize the virtualization technology to construct the distributed system with the virtual resources, also including high energy physics. This paper introduce a method used in high energy physics that supports multiple resource group and preemptable cloud resource scheduling, combining virtual machine with HTCondor (a batch system). It makes resource controlling more flexible and more efficient and makes resource scheduling independent of job scheduling. Firstly, the resources belong to different experiment-groups, and the type of user-groups mapping to resource-groups(same as experiment-group) is one-to-one or many-to-one. In order to make the confused group simply to be managed, we designed the permission controlling component to ensure that the different resource-groups can get the suitable jobs. Secondly, for the purpose of elastically allocating resources for suitable resource-group, it is necessary to schedule resources like scheduling jobs. So this paper designs the cloud resource scheduling to maintain a resource queue and allocate an appropriate amount of virtual resources to the request resource-group. Thirdly, in some kind of situations, because of the resource occupied for a long time, resources need to be preempted. This paper adds the preemption function for the resource scheduling that implement resource preemption based on the group priority. Additionally, the way to preempting is soft that when virtual resources are preempted, jobs will not be killed but also be held and rematched later. It is implemented with the help of HTCondor, storing the held job information in scheduler, releasing the job to idle status and doing second matcher. In IHEP (institute of high energy physics), we have built a batch system based on HTCondor with a virtual resources pool based on Openstack. And this paper will show some cases of experiment JUNO and LHAASO. The result indicates that multi-group and preemptable resource scheduling is efficient to support multi-group and soft preemption. Additionally, the permission controlling component has been used in the local computing cluster, supporting for experiment JUNO, CMS and LHAASO, and the scale will be expanded to more experiments at the first half year, including DYW, BES and so on. Its evidence that the permission controlling is efficient.

Efficacy of induction therapy with ATG and intravenous immunoglobulins in patients with low-level donor-specific HLA-antibodies.

PubMed

Bächler, K; Amico, P; Hönger, G; Bielmann, D; Hopfer, H; Mihatsch, M J; Steiger, J; Schaub, S

2010-05-01

Low-level donor-specific HLA-antibodies (HLA-DSA) (i.e. detectable by single-antigen flow beads, but negative by complement-dependent cytotoxicity crossmatch) represent a risk factor for early allograft rejection. The short-term efficacy of an induction regimen consisting of polyclonal anti-T-lymphocyte globulin (ATG) and intravenous immunoglobulins (IvIg) in patients with low-level HLA-DSA is unknown. In this study, we compared 67 patients with low-level HLA-DSA not having received ATG/IvIg induction (historic control) with 37 patients, who received ATG/IvIg induction. The two groups were equal regarding retransplants, HLA-matches, number and class of HLA-DSA. The overall incidence of clinical/subclinical antibody-mediated rejection (AMR) was lower in the ATG/IvIg than in the historic control group (38% vs. 55%; p = 0.03). This was driven by a significantly lower rate of clinical AMR (11% vs. 46%; p = 0.0002). Clinical T-cell-mediated rejection (TCR) was significantly lower in the ATG/IvIg than in the historic control group (0% vs. 50%; p < 0.0001). Within the first year, allograft loss due to AMR occurred in 7.5% in the historic control and in 0% in the ATG/IvIg group. We conclude that in patients with low-level HLA-DSA, ATG/IvIg induction significantly reduces TCR and the severity of AMR, but the high rate of subclinical AMR suggests an insufficient control of the humoral immune response.

Neuropsychological Profiles on the WAIS-IV of Adults With ADHD.

PubMed

Theiling, Johanna; Petermann, Franz

2016-11-01

The aim of the study was to investigate the pattern of neuropsychological profiles on the Wechsler Adult Intelligence Scale-IV (WAIS-IV) for adults With ADHD relative to randomly matched controls and to assess overall intellectual ability discrepancies of the Full Scale Intelligence Quotient (FSIQ) and the General Ability Index (GAI). In all, 116 adults With ADHD and 116 controls between 16 and 71 years were assessed. Relative to controls, adults With ADHD show significant decrements in subtests with working memory and processing speed demands with moderate to large effect sizes and a higher GAI in comparison with the FSIQ. This suggests first that deficits identified with previous WAIS versions are robust in adults With ADHD and remain deficient when assessed with the WAIS-IV; second that the WAIS-IV reliably differentiates between patients and controls; and third that a reduction of the FSIQ is most likely due to a decrement in working memory and processing speed abilities. The findings have essential implications for the diagnostic process. © The Author(s) 2014.

Characterization of Tactical Departure Scheduling in the National Airspace System

NASA Technical Reports Server (NTRS)

Capps, Alan; Engelland, Shawn A.

2011-01-01

This paper discusses and analyzes current day utilization and performance of the tactical departure scheduling process in the National Airspace System (NAS) to understand the benefits in improving this process. The analysis used operational air traffic data from over 1,082,000 flights during the month of January, 2011. Specific metrics included the frequency of tactical departure scheduling, site specific variances in the technology's utilization, departure time prediction compliance used in the tactical scheduling process and the performance with which the current system can predict the airborne slot that aircraft are being scheduled into from the airport surface. Operational data analysis described in this paper indicates significant room for improvement exists in the current system primarily in the area of reduced departure time prediction uncertainty. Results indicate that a significant number of tactically scheduled aircraft did not meet their scheduled departure slot due to departure time uncertainty. In addition to missed slots, the operational data analysis identified increased controller workload associated with tactical departures which were subject to traffic management manual re-scheduling or controller swaps. An analysis of achievable levels of departure time prediction accuracy as obtained by a new integrated surface and tactical scheduling tool is provided to assess the benefit it may provide as a solution to the identified shortfalls. A list of NAS facilities which are likely to receive the greatest benefit from the integrated surface and tactical scheduling technology are provided.

Investigating the Impact of Off-Nominal Events on High-Density "Green" Arrivals

NASA Technical Reports Server (NTRS)

Callatine, Todd J.; Cabrall, Christopher; Kupfer, Michael; Martin, Lynne; Mercer, Joey; Palmer, Everett A.

2012-01-01

Trajectory-based controller tools developed to support a schedule-based terminal-area air traffic management (ATM) concept have been shown effective for enabling green arrivals along Area Navigation (RNAV) routes in moderately high-density traffic conditions. A recent human-in-the-loop simulation investigated the robustness of the concept and tools to off-nominal events events that lead to situations in which runway arrival schedules require adjustments and controllers can no longer use speed control alone to impose the necessary delays. Study participants included a terminal-area Traffic Management Supervisor responsible for adjusting the schedules. Sector-controller participants could issue alternate RNAV transition routes to absorb large delays. The study also included real-time winds/wind-forecast changes. The results indicate that arrival spacing accuracy, schedule conformance, and tool usage and usefulness are similar to that observed in simulations of nominal operations. However, the time and effort required to recover from an off-nominal event is highly context-sensitive, and impacted by the required schedule adjustments and control methods available for managing the evolving situation. The research suggests ways to bolster the off-nominal recovery process, and highlights challenges related to using human-in-the-loop simulation to investigate the safety and robustness of advanced ATM concepts.

21 CFR 1301.33 - Application for bulk manufacture of Schedule I and II substances.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Application for bulk manufacture of Schedule I and... manufacture of Schedule I and II substances. (a) In the case of an application for registration or reregistration to manufacture in bulk a basic class of controlled substance listed in Schedule I or II, the...

WAYS OF ACQUIRING FLYING PHOBIA.

PubMed

Schindler, Bettina; Vriends, Noortje; Margraf, Jürgen; Stieglitz, Rolf-Dieter

2016-02-01

The few studies that have explored how flying phobia is acquired have produced contradictory results. We hypothesized that classical conditioning plays a role in acquiring flying phobia and investigated if vicarious (model) learning, informational learning through media, and experiencing stressful life events at the time of onset of phobia also play a role. Thirty patients with flying phobia and thirty healthy controls matched on age, sex, and education were interviewed with the Mini-DIPS, the short German version of the Anxiety Disorders Interview Schedule (DSM-IV diagnostic criteria) and the Fear-of-Flying History Interview. Fifty Percent of patients with flying phobia and 53% of healthy controls reported frightening events in the air. There was no significant difference between the two samples. Thus there were not more classical conditioning events for patients with flying phobia. There also was no significant difference between the two samples for vicarious (model) learning: 37% of flying phobia patients and 23% of healthy controls felt influenced by model learning. The influence of informational learning through media was significantly higher for the clinical sample (70%) than for the control group (37%). Patients with flying phobia experienced significantly more stressful life events in the period of their frightening flight experience (60%) than healthy controls (19%). Frightening experiences while flying are quite common, but not everybody develops a flying phobia. Stressful life events and other factors might enhance conditionability. Informational learning through negative media reports probably reinforces the development of flying phobia. Clinical implications are discussed. © 2015 Wiley Periodicals, Inc.

Protocols for distributive scheduling

NASA Technical Reports Server (NTRS)

Richards, Stephen F.; Fox, Barry

1993-01-01

The increasing complexity of space operations and the inclusion of interorganizational and international groups in the planning and control of space missions lead to requirements for greater communication, coordination, and cooperation among mission schedulers. These schedulers must jointly allocate scarce shared resources among the various operational and mission oriented activities while adhering to all constraints. This scheduling environment is complicated by such factors as the presence of varying perspectives and conflicting objectives among the schedulers, the need for different schedulers to work in parallel, and limited communication among schedulers. Smooth interaction among schedulers requires the use of protocols that govern such issues as resource sharing, authority to update the schedule, and communication of updates. This paper addresses the development and characteristics of such protocols and their use in a distributed scheduling environment that incorporates computer-aided scheduling tools. An example problem is drawn from the domain of space shuttle mission planning.

Distributed project scheduling at NASA: Requirements for manual protocols and computer-based support

NASA Technical Reports Server (NTRS)

Richards, Stephen F.

1992-01-01

The increasing complexity of space operations and the inclusion of interorganizational and international groups in the planning and control of space missions lead to requirements for greater communication, coordination, and cooperation among mission schedulers. These schedulers must jointly allocate scarce shared resources among the various operational and mission oriented activities while adhering to all constraints. This scheduling environment is complicated by such factors as the presence of varying perspectives and conflicting objectives among the schedulers, the need for different schedulers to work in parallel, and limited communication among schedulers. Smooth interaction among schedulers requires the use of protocols that govern such issues as resource sharing, authority to update the schedule, and communication of updates. This paper addresses the development and characteristics of such protocols and their use in a distributed scheduling environment that incorporates computer-aided scheduling tools. An example problem is drawn from the domain of Space Shuttle mission planning.

How should periods without social interaction be scheduled? Children's preference for practical schedules of positive reinforcement.

PubMed

Luczynski, Kevin C; Hanley, Gregory P

2014-01-01

Several studies have shown that children prefer contingent reinforcement (CR) rather than yoked noncontingent reinforcement (NCR) when continuous reinforcement is programmed in the CR schedule. Preference has not, however, been evaluated for practical schedules that involve CR. In Study 1, we assessed 5 children's preference for obtaining social interaction via a multiple schedule (periods of fixed-ratio 1 reinforcement alternating with periods of extinction), a briefly signaled delayed reinforcement schedule, and an NCR schedule. The multiple schedule promoted the most efficient level of responding. In general, children chose to experience the multiple schedule and avoided the delay and NCR schedules, indicating that they preferred multiple schedules as the means to arrange practical schedules of social interaction. In Study 2, we evaluated potential controlling variables that influenced 1 child's preference for the multiple schedule and found that the strong positive contingency was the primary variable. © Society for the Experimental Analysis of Behavior.

A laboratory comparison of clockwise and counter-clockwise rapidly rotating shift schedules, part II : performance : final report.

DOT National Transportation Integrated Search

2002-07-01

INTRODUCTION. Many Air Traffic Control Specialists (ATCSs) work a relatively unique counter-clockwise, rapidly rotating shift schedule. Although arguments against these kinds of schedules are prevalent in the literature, few studies have examined rot...

75 FR 47451 - Schedules of Controlled Substances; Placement of 2,5-Dimethoxy-4-(n)-propylthiophenethylamine and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... only one piece of background scientific data used to evaluate the abuse potential of drugs or other... opiates previously scheduled under the CSA. Even though the scheduling of BZP was finalized more than six...

40 CFR 716.60 - Reporting schedule.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

40 CFR 716.60 - Reporting schedule.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

40 CFR 716.60 - Reporting schedule.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

40 CFR 716.60 - Reporting schedule.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

40 CFR 716.60 - Reporting schedule.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Reporting schedule. 716.60 Section 716.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.60 Reporting schedule. (a) General requirements...

40 CFR 52.1175 - Compliance schedules.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 4 2011-07-01 2011-07-01 false Compliance schedules. 52.1175 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Michigan § 52.1175 Compliance schedules. (a... Rule 336.49 of the Michigan Air Pollution Control Commission provides for individual compliance...

Planning and Scheduling of Payloads of AstroSat During Initial and Normal Phase Observations

NASA Astrophysics Data System (ADS)

Pandiyan, R.; Subbarao, S. V.; Nagamani, T.; Rao, Chaitra; Rao, N. Hari Prasad; Joglekar, Harish; Kumar, Naresh; Dumpa, Surya Ratna Prakash; Chauhan, Anshu; Dakshayani, B. P.

2017-06-01

On 28th September 2015, India launched its first astronomical space observatory AstroSat, successfully. AstroSat carried five astronomy payloads, namely, (i) Cadmium Zinc Telluride Imager (CZTI), (ii) Large Area X-ray Proportional Counter (LAXPC), (iii) Soft X-ray Telescope (SXT), (iv) Ultra Violet Imaging Telescope (UVIT) and (v) Scanning Sky Monitor (SSM) and therefore, has the capability to observe celestial objects in multi-wavelength. Four of the payloads are co-aligned along the positive roll axis of the spacecraft and the remaining one is placed along the positive yaw axis direction. All the payloads are sensitive to bright objects and specifically, require avoiding bright Sun within a safe zone of their bore axes in orbit. Further, there are other operational constraints both from spacecraft side and payloads side which are to be strictly enforced during operations. Even on-orbit spacecraft manoeuvres are constrained to about two of the axes in order to avoid bright Sun within this safe zone and a special constrained manoeuvre is exercised during manoeuvres. The planning and scheduling of the payloads during the Performance Verification (PV) phase was carried out in semi-autonomous/manual mode and a complete automation is exercised for normal phase/Guaranteed Time Observation (GuTO) operations. The process is found to be labour intensive and several operational software tools, encompassing spacecraft sub-systems, on-orbit, domain and environmental constraints, were built-in and interacted with the scheduling tool for appropriate decision-making and science scheduling. The procedural details of the complex scheduling of a multi-wavelength astronomy space observatory and their working in PV phase and in normal/GuTO phases are presented in this paper.

Peer-to-peer Cooperative Scheduling Architecture for National Grid Infrastructure

NASA Astrophysics Data System (ADS)

Matyska, Ludek; Ruda, Miroslav; Toth, Simon

For some ten years, the Czech National Grid Infrastructure MetaCentrum uses a single central PBSPro installation to schedule jobs across the country. This centralized approach keeps a full track about all the clusters, providing support for jobs spanning several sites, implementation for the fair-share policy and better overall control of the grid environment. Despite a steady progress in the increased stability and resilience to intermittent very short network failures, growing number of sites and processors makes this architecture, with a single point of failure and scalability limits, obsolete. As a result, a new scheduling architecture is proposed, which relies on higher autonomy of clusters. It is based on a peer to peer network of semi-independent schedulers for each site or even cluster. Each scheduler accepts jobs for the whole infrastructure, cooperating with other schedulers on implementation of global policies like central job accounting, fair-share, or submission of jobs across several sites. The scheduling system is integrated with the Magrathea system to support scheduling of virtual clusters, including the setup of their internal network, again eventually spanning several sites. On the other hand, each scheduler is local to one of several clusters and is able to directly control and submit jobs to them even if the connection of other scheduling peers is lost. In parallel to the change of the overall architecture, the scheduling system itself is being replaced. Instead of PBSPro, chosen originally for its declared support of large scale distributed environment, the new scheduling architecture is based on the open-source Torque system. The implementation and support for the most desired properties in PBSPro and Torque are discussed and the necessary modifications to Torque to support the MetaCentrum scheduling architecture are presented, too.

Representations and evolutionary operators for the scheduling of pump operations in water distribution networks.

PubMed

López-Ibáñez, Manuel; Prasad, T Devi; Paechter, Ben

2011-01-01

Reducing the energy consumption of water distribution networks has never had more significance. The greatest energy savings can be obtained by carefully scheduling the operations of pumps. Schedules can be defined either implicitly, in terms of other elements of the network such as tank levels; or explicitly, by specifying the time during which each pump is on/off. The traditional representation of explicit schedules is a string of binary values with each bit representing pump on/off status during a particular time interval. In this paper, we formally define and analyze two new explicit representations based on time-controlled triggers, where the maximum number of pump switches is established beforehand and the schedule may contain fewer than the maximum number of switches. In these representations, a pump schedule is divided into a series of integers with each integer representing the number of hours for which a pump is active/inactive. This reduces the number of potential schedules compared to the binary representation, and allows the algorithm to operate on the feasible region of the search space. We propose evolutionary operators for these two new representations. The new representations and their corresponding operations are compared with the two most-used representations in pump scheduling, namely, binary representation and level-controlled triggers. A detailed statistical analysis of the results indicates which parameters have the greatest effect on the performance of evolutionary algorithms. The empirical results show that an evolutionary algorithm using the proposed representations is an improvement over the results obtained by a recent state of the art hybrid genetic algorithm for pump scheduling using level-controlled triggers.

Doctor and pharmacy shopping for controlled substances.

PubMed

Peirce, Gretchen L; Smith, Michael J; Abate, Marie A; Halverson, Joel

2012-06-01

Prescription drug abuse is a major health concern nationwide, with West Virginia having one of the highest prescription drug death rates in the United States. Studies are lacking that compare living subjects with persons who died from drug overdose for evidence of doctor and pharmacy shopping for controlled substances. The study objectives were to compare deceased and living subjects in West Virginia for evidence of prior doctor and pharmacy shopping for controlled substances and to identify factors associated with drug-related death. A secondary data study was conducted using controlled substance, Schedule II-IV, prescription data from the West Virginia Controlled Substance Monitoring Program and drug-related death data compiled by the Forensic Drug Database between July 2005 and December 2007. A case-control design compared deceased subjects 18 years and older whose death was drug related with living subjects for prior doctor and pharmacy shopping. Logistic regression identified factors related to the odds of drug-related death. A significantly greater proportion of deceased subjects were doctor shoppers (25.21% vs. 3.58%) and pharmacy shoppers (17.48% vs. 1.30%) than living subjects. Approximately 20.23% of doctor shoppers were also pharmacy shoppers, and 55.60% of pharmacy shoppers were doctor shoppers. Younger age, greater number of prescriptions dispensed, exposure to opioids and benzodiazepines, and doctor and pharmacy shopping were factors with greater odds of drug-related death. Doctor and pharmacy shopping involving controlled substances were identified, and shopping behavior was associated with drug-related death. Prescription monitoring programs may be useful in identifying potential shoppers at the point of care.

77 FR 46519 - Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and Proposed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-03

... Production Quotas for Schedule I and II Controlled Substances and Proposed Assessment of Annual Needs for the... the Controlled Substances Act (CSA) and assessment of annual needs for the list I chemicals ephedrine... proposed 2013 aggregate production quotas and assessment of annual needs, DEA has taken into account the...

75 FR 64744 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... applicants for registration to import a basic class of any controlled substance in schedule I or II are, and... this section to a bulk manufacturer of a controlled substance in schedule I or II, and prior to issuing... Enforcement Administration (DEA) to be registered as an importer of Remifentanil (9739), a basic class of...

77 FR 43861 - Importer of Controlled Substances; Notice Of Application; Cody Laboratories, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... basic class of any controlled substance in schedule I or II are, and will continue to be, required to... importer of the following basic classes of controlled substances: Drug Schedule Opium, Raw (9600) II Concentrate Poppy Straw (9670) II Tapentadol (9780) II The company plans to import narcotic raw materials for...

76 FR 77253 - Importer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... applicants for registration to import a basic class of any controlled substance in schedule I or II are, and... this Section to a bulk manufacturer of a controlled substance in schedule I or II, and prior to issuing... Enforcement Administration (DEA) to be registered as an importer of Remifentanil (9739), a basic class of...

Mechanisms of blood pressure alterations in response to the Valsalva maneuver in postural tachycardia syndrome

NASA Technical Reports Server (NTRS)

Sandroni, P.; Novak, V.; Opfer-Gehrking, T. L.; Huck, C. A.; Low, P. A.

2000-01-01

The postural tachycardia syndrome (POTS) is characterized clinically by orthostatic lightheadedness and tachycardia. When these patients perform a Valsalva maneuver, there is an excessive blood pressure increment after cessation of the maneuver (phase IV) that is sometimes associated with headaches. It is not known whether excessive phase IV is due to excessive peripheral vascular tone (an alpha-adrenergic mechanism) or is a manifestation of increased beta-adrenergic tone (hyperadrenergic state). The authors undertook a pharmacologic study evaluating the effect of intravenous phentolamine (alpha-adrenergic antagonist) and propranolol (beta-adrenergic antagonist) on the different phases of the Valsalva maneuver in a group of patients with POTS and age-matched normal control subjects. Patients with POTS had mean phases, when compared with controls, that were characterized by more negative II_E (p = 0.07), smaller II_L (p = 0.04), and significantly larger phase IV (p = 0.001). The effect of phentolamine was qualitatively and quantitatively different in POTS when compared with controls. Ten mg phentolamine in controls resulted in a significant accentuation of phase II_E (p = 0.001), attenuation of phase II_L (p = 0.002), and increase of phase IV (57.6 vs 30.7 mm Hg; p = 0.025). These changes resembled those of patients with POTS at baseline. In patients with POTS, the phase II abnormalities, already present, were further accentuated (p <0.001), and phase IV became smaller (50.6 vs 73.8 mm Hg; p = 0.09). Propranolol had no significant effect on phases II_E and II_L, but significantly reduced phase IV in both controls (p <0.05) and in patients with POTS (p <0.001) and improved the headache symptoms, when present, during and after phase IV. The authors conclude that phase IV is mainly under beta-adrenergic regulation and that the exaggerated phase IV in POTS is a result of a hyperadrenergic state.

A Baseline Load Schedule for the Manual Calibration of a Force Balance

NASA Technical Reports Server (NTRS)

Ulbrich, N.; Gisler, R.

2013-01-01

A baseline load schedule for the manual calibration of a force balance is defined that takes current capabilities at the NASA Ames Balance Calibration Laboratory into account. The chosen load schedule consists of 18 load series with a total of 194 data points. It was designed to satisfy six requirements: (i) positive and negative loadings should be applied for each load component; (ii) at least three loadings should be applied between 0 % and 100 % load capacity; (iii) normal and side force loadings should be applied at the forward gage location, aft gage location, and the balance moment center; (iv) the balance should be used in "up" and "down" orientation to get positive and negative axial force loadings; (v) the constant normal and side force approaches should be used to get the rolling moment loadings; (vi) rolling moment loadings should be obtained for 0, 90, 180, and 270 degrees balance orientation. In addition, three different approaches are discussed in the paper that may be used to independently estimate the natural zeros, i.e., the gage outputs of the absolute load datum of the balance. These three approaches provide gage output differences that can be used to estimate the weight of both the metric and non-metric part of the balance. Data from the calibration of a six-component force balance will be used in the final manuscript of the paper to illustrate characteristics of the proposed baseline load schedule.

The F-111D Retention Issue.

DTIC Science & Technology

1986-06-06

Washington D.C.: Office of Air Force History, 1978), pp. 234, 241, 254, ?59. 3 Knaack, Post- Worl -g War 11 Fighters, p. 254. 7 CHAPTER 2 HISTORICAL...The F-IlIA in Southeast Asia: 19 Second Deployment The F-I11B 22 The F-111C 25 The F-1111 25 The F-1IE 30 The F-1I1F 33 iv...Sortie 98 3-13 Maintenance Plan / Scheduling Effectiveness 99 3-14 War Readiness Spares Kit (WRSK) Fill Rate 99 3-15 WRSK / BLSS Withdrawals 100 3-16

Schedules of Controlled Substances: Placement of FDA-Approved Products of Oral Solutions Containing Dronabinol [(-)-delta-9-transtetrahydrocannabinol (delta-9-THC)] in Schedule II. Interim final rule, with request for comments.

PubMed

2017-03-23

On July 1, 2016, the U.S. Food and Drug Administration (FDA) approved a new drug application for Syndros, a drug product consisting of dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] oral solution. Thereafter, the Department of Health and Human Services (HHS) provided the Drug Enforcement Administration (DEA) with a scheduling recommendation that would result in Syndros (and other oral solutions containing dronabinol) being placed in schedule II of the Controlled Substances Act (CSA). In accordance with the CSA, as revised by the Improving Regulatory Transparency for New Medical Therapies Act, DEA is hereby issuing an interim final rule placing FDA-approved products of oral solutions containing dronabinol in schedule II of the CSA.

Earth Observing System (EOS) Advanced Microwave Sounding Unit-A (AMSU-A) schedule plan

NASA Technical Reports Server (NTRS)

1994-01-01

This report describes Aerojet's methods and procedures used to control and administer contractual schedules for the EOS/AMSU-A program. Included are the following: the master, intermediate, and detail schedules; critical path analysis; and the total program logic network diagrams.

Scheduling Dependent Real-Time Activities

DTIC Science & Technology

1990-08-01

dependency relationships in a way that is suitable for all real - time systems . This thesis provides an algorithm, called DASA, that is effective for...scheduling the class of real - time systems known as supervisory control systems. Simulation experiments that account for the time required to make scheduling

Irrigation scheduling and controlling crop water use efficiency with Infrared Thermometry

USDA-ARS?s Scientific Manuscript database

Scientific methods for irrigation scheduling include weather, soil and plant-based techniques. Infrared thermometers can be used a non-invasive practice to monitor canopy temperature and better manage irrigation scheduling. This presentation will discuss the theoretical basis for monitoring crop can...

Issues in NASA Program and Project Management: Focus on Project Planning and Scheduling

NASA Technical Reports Server (NTRS)

Hoffman, Edward J. (Editor); Lawbaugh, William M. (Editor)

1997-01-01

Topics addressed include: Planning and scheduling training for working project teams at NASA, overview of project planning and scheduling workshops, project planning at NASA, new approaches to systems engineering, software reliability assessment, and software reuse in wind tunnel control systems.

A laboratory comparison of clockwise and counter-clockwise rapidly rotating shift schedules, part I, sleep : final report.

DOT National Transportation Integrated Search

2002-05-01

INTRODUCTION. Many air traffic control specialists work relatively unique counter-clockwise, rapidly rotating shift schedules. Researchers recommend, however, that if rotating schedules are to be used, they should rotate in a clockwise, rather than a...

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague-Dawley rat.

PubMed

Bake, T; Morgan, D G A; Mercer, J G

2014-04-10

Providing rats and mice with access to palatable high fat diets for a short period each day induces the consumption of substantial binge-like meals. Temporal food intake structure (assessed using the TSE PhenoMaster/LabMaster system) and metabolic outcomes (oral glucose tolerance tests [oGTTs], and dark phase glucose and insulin profiles) were examined in Sprague-Dawley rats given access to 60% high fat diet on one of 3 different feeding regimes: ad libitum access (HF), daily 2 h-scheduled access from 6 to 8 h into the dark phase (2 h-HF), and twice daily 1 h-scheduled access from both 1-2 h and 10-11 h into the dark phase (2×1 h-HF). Control diet remained available during the scheduled access period. HF rats had the highest caloric intake, body weight gain, body fat mass and plasma insulin. Both schedule-fed groups rapidly adapted their feeding behaviour to scheduled access, showing large meal/bingeing behaviour with 44% or 53% of daily calories consumed from high fat diet during the 2 h or 2×1 h scheduled feed(s), respectively. Both schedule-fed groups had an intermediate caloric intake and body fat mass compared to HF and control (CON) groups. Temporal analysis of food intake indicated that schedule-fed rats consumed large binge-type high fat meals without a habitual decrease in preceding intake on control diet, suggesting that a relative hypocaloric state was not responsible or required for driving the binge episode, and substantiating previous indications that binge eating may not be driven by hypothalamic energy balance neuropeptides. In an oGTT, both schedule-fed groups had impaired glucose tolerance with higher glucose and insulin area under the curve, similar to the response in ad libitum HF fed rats, suggesting that palatable feeding schedules represent a potential metabolic threat. Scheduled feeding on high fat diet produces similar metabolic phenotypes to mandatory (no choice) high fat feeding and may be a more realistic platform for mechanistic study of diet-induced obesity. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

40 CFR 52.227 - Control strategy and regulations: Particulate matter, Metropolitan Los Angeles Intrastate Region.

Code of Federal Regulations, 2014 CFR

2014-07-01

... IMPLEMENTATION PLANS California § 52.227 Control strategy and regulations: Particulate matter, Metropolitan Los... Los Angeles Intrastate Region. (1) Los Angeles County Air Pollution Control District: (i) Regulation IV, Rule 68.1. (2) Riverside County Air Pollution Control District: (i) Regulation IV, Rule 54 for...

40 CFR 52.227 - Control strategy and regulations: Particulate matter, Metropolitan Los Angeles Intrastate Region.

Code of Federal Regulations, 2013 CFR

2013-07-01

... IMPLEMENTATION PLANS California § 52.227 Control strategy and regulations: Particulate matter, Metropolitan Los... Los Angeles Intrastate Region. (1) Los Angeles County Air Pollution Control District: (i) Regulation IV, Rule 68.1. (2) Riverside County Air Pollution Control District: (i) Regulation IV, Rule 54 for...

40 CFR 52.227 - Control strategy and regulations: Particulate matter, Metropolitan Los Angeles Intrastate Region.

Code of Federal Regulations, 2012 CFR

2012-07-01

... IMPLEMENTATION PLANS California § 52.227 Control strategy and regulations: Particulate matter, Metropolitan Los... Los Angeles Intrastate Region. (1) Los Angeles County Air Pollution Control District: (i) Regulation IV, Rule 68.1. (2) Riverside County Air Pollution Control District: (i) Regulation IV, Rule 54 for...

Sensitivity and bias under conditions of equal and unequal academic task difficulty.

PubMed

Reed, Derek D; Martens, Brian K

2008-01-01

We conducted an experimental analysis of children's relative problem-completion rates across two workstations under conditions of equal (Experiment 1) and unequal (Experiment 2) problem difficulty. Results were described using the generalized matching equation and were evaluated for degree of schedule versus stimulus control. Experiment 1 involved a symmetrical choice arrangement in which the children could earn points exchangeable for rewards contingent on correct math problem completion. Points were delivered according to signaled variable-interval schedules at each workstation. For 2 children, relative rates of problem completion appeared to have been controlled by the schedule requirements in effect and matched relative rates of reinforcement, with sensitivity values near 1 and bias values near 0. Experiment 2 involved increasing the difficulty of math problems at one of the workstations. Sensitivity values for all 3 participants were near 1, but a substantial increase in bias toward the easier math problems was observed. This bias was possibly associated with responding at the more difficult workstation coming under stimulus control rather than schedule control.

Geochemical controls on microbial nitrate-dependent U(IV) oxidation

USGS Publications Warehouse

Senko, John M.; Suflita, Joseph M.; Krumholz, Lee R.

2005-01-01

After reductive immobilization of uranium, the element may be oxidized and remobilized in the presence of nitrate by the activity of dissimilatory nitrate-reducing bacteria. We examined controls on microbially mediated nitrate-dependent U(IV) oxidation in landfill leachate-impacted subsurface sediments. Nitrate-dependent U(IV)-oxidizing bacteria were at least two orders of magnitude less numerous in these sediments than glucose- or Fe(II)-oxidizing nitrate-reducing bacteria and grew more slowly than the latter organisms, suggesting that U(IV) is ultimately oxidized by Fe(III) produced by nitrate-dependent Fe(II)-oxidizing bacteria or by oxidation of Fe(II) by nitrite that accumulates during organotrophic dissimilatory nitrate reduction. We examined the effect of nitrate and reductant concentration on nitrate-dependent U(IV) oxidation in sediment incubations and used the initial reductive capacity (RDC = [reducing equivalents] - [oxidizing equivalents]) of the incubations as a unified measurement of the nitrate or reductant concentration. When we lowered the RDC with progressively higher nitrate concentrations, we observed a corresponding increase in the extent of U(IV) oxidation, but did not observe this relationship between RDC and U(IV) oxidation rate, especially when RDC > 0, suggesting that nitrate concentration strongly controls the extent, but not the rate of nitrate-dependent U(IV) oxidation. On the other hand, when we raised the RDC in sediment incubations with progressively higher reductant (acetate, sulfide, soluble Fe(II), or FeS) concentrations, we observed progressively lower extents and rates of nitrate-dependent U(IV) oxidation. Acetate was a relatively poor inhibitor of nitrate-dependent U(IV) oxidation, while Fe(II) was the most effective inhibitor. Based on these results, we propose that it may be possible to predict the stability of U(IV) in a bioremediated aquifer based on the geochemical characteristics of that aquifer.

FAST TRACK COMMUNICATION Generation of stable multi-jets by flow-limited field-injection electrostatic spraying and their control via I-V characteristics

NASA Astrophysics Data System (ADS)

Gu, W.; Heil, P. E.; Choi, H.; Kim, K.

2010-12-01

The I-V characteristics of flow-limited field-injection electrostatic spraying (FFESS) were investigated, exposing a new way to predict and control the specific spraying modes from single-jet to multi-jet. Monitoring the I-V characteristics revealed characteristic drops in the current upon formation of an additional jet in the multi-jet spraying mode. For fixed jet numbers, space-charge-limited current behaviour was measured which was attributed to space charge in the dielectric liquids between the needle electrode and the nozzle opening. The present work establishes that FFESS can, in particular, generate stable multiple jets and that their control is possible through monitoring the I-V characteristics. This can allow for automatic control of the FFESS process and expedite its future scientific and industrial applications.

The monitoring of trade in and control of psychotropic substances to guard against their diversion.

PubMed

Bayer, I

1983-01-01

The establishment of international control of opiates has been an important achievement of the international community; this is substantiated by the fact that, at the beginning of this century, legally manufactured morphine and heroin were the principal sources of illicit supply, whereas at present the illicit traffic in these drugs is supplied from illicit sources. The poppy straw process has helped to promote measures to control opium poppy cultivation in a number of European countries; Turkey has been a successful example of such control. The present large-scale illicit traffic in cannabis resin and cocaine is the consequence of the lack of the implementation of provisions of the Single Convention on Narcotic Drugs, 1961, to control the cannabis plant and the coca bush at the national level. The provisions of the 1971 Convention on Psychotropic Substances, being largely a result of international compromise, are not designed in the best possible way to prevent the diversion of psychotropic substances from legal sources to illicit channels. There are no appropriate provisions for the control and monitoring of international transactions. There is a discrepancy between the rather limited scope of international control of substances listed in schedules III and IV of the 1971 Convention and the much larger scope of control of hypnotics, sedatives and tranquillizers at national levels. The provisions of the 1971 Convention, however, constitute a legal basis for bilateral and multilateral actions for the detection of suspected diversion cases, and offer possibilities of promoting the prevention of diversion of psychotropic substances. At present, the relationship between the control of psychotropic drugs, including the prevention of diversion and the organization of the national drug supply system, as well as the efficacy of national control over pharmaceutical products, has not been fully recognized by the international community.

Techniques for Combined Arms for Air Defense

DTIC Science & Technology

2016-07-29

loss remain in effect until communications are regained. Changes to ROE and supplemental fire control measures scheduled to go into effect after...communications are lost will be implemented as scheduled . Fire Control Orders Fire control orders are commands used to control engagements on a case...or a sleep matt over windshields (Figure 3-2). Camouflage is one of the basic weapons of war. The importance, the principles, and the techniques of

In-Space Crew-Collaborative Task Scheduling

NASA Technical Reports Server (NTRS)

Jaap, John; Meyer, Patrick; Davis, Elizabeth; Richardson, Lea

2007-01-01

For all past and current human space missions, the final scheduling of tasks to be done in space has been devoid of crew control, flexibility, and insight. Ground controllers, with minimal input from the crew, schedule the tasks and uplink the timeline to the crew or uplink the command sequences to the hardware. Prior to the International Space Station (ISS), the crew could make requests about tomorrow s timeline, they could omit a task, or they could request that something in the timeline be delayed. This lack of control over one's own schedule has had negative consequences. There is anecdotal consensus among astronauts that control over their own schedules will mitigate the stresses of long duration missions. On ISS, a modicum of crew control is provided by the job jar. Ground controllers prepare a task list (a.k.a. "job jar") of non-conflicting tasks from which jobs can be chosen by the in space crew. Because there is little free time and few interesting non-conflicting activities, the task-list approach provides little relief from the tedium of being micro-managed by the timeline. Scheduling for space missions is a complex and laborious undertaking which usually requires a large cadre of trained specialists and suites of complex software tools. It is a giant leap from today s ground prepared timeline (with a job jar) to full crew control of the timeline. However, technological advances, currently in-work or proposed, make it reasonable to consider scheduling a collaborative effort by the ground-based teams and the in-space crew. Collaboration would allow the crew to make minor adjustments, add tasks according to their preferences, understand the reasons for the placement of tasks on the timeline, and provide them a sense of control. In foreseeable but extraordinary situations, such as a quick response to anomalies and extended or unexpected loss of signal, the crew should have the autonomous ability to make appropriate modifications to the timeline, extend the timeline, or even start over with a new timeline. The Vision for Space Exploration (VSE), currently being pursued by the National Aeronautics and Space Administration (NASA), will send humans to Mars in a few decades. Stresses on the human mind will be exacerbated by the longer durations and greater distances, and it will be imperative to implement stress-reducing innovations such as giving the crew control of their daily activities.

32 CFR 229.21 - Surveys and schedules.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Surveys and schedules. 229.21 Section 229.21...) MISCELLANEOUS PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 229.21 Surveys and schedules. (a... Tennessee Valley Authority will develop plans for surveying lands under each agency's control to determine...

18 CFR 1312.21 - Surveys and schedules.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Surveys and schedules... OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.21 Surveys and schedules. (a) The Secretaries... Authority will develop plans for surveying lands under each agency's control to determine the nature and...

32 CFR 229.21 - Surveys and schedules.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Surveys and schedules. 229.21 Section 229.21...) MISCELLANEOUS PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 229.21 Surveys and schedules. (a... Tennessee Valley Authority will develop plans for surveying lands under each agency's control to determine...

32 CFR 229.21 - Surveys and schedules.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Surveys and schedules. 229.21 Section 229.21...) MISCELLANEOUS PROTECTION OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 229.21 Surveys and schedules. (a... Tennessee Valley Authority will develop plans for surveying lands under each agency's control to determine...

18 CFR 1312.21 - Surveys and schedules.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Surveys and schedules... OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.21 Surveys and schedules. (a) The Secretaries... Authority will develop plans for surveying lands under each agency's control to determine the nature and...

18 CFR 1312.21 - Surveys and schedules.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Surveys and schedules... OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.21 Surveys and schedules. (a) The Secretaries... Authority will develop plans for surveying lands under each agency's control to determine the nature and...

18 CFR 1312.21 - Surveys and schedules.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Surveys and schedules... OF ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 1312.21 Surveys and schedules. (a) The Secretaries... Authority will develop plans for surveying lands under each agency's control to determine the nature and...

"The stone which the builders rejected...": Delay of reinforcement and response rate on fixed-interval and related schedules.

PubMed

Wearden, J H; Lejeune, Helga

2006-02-28

The article deals with response rates (mainly running and peak or terminal rates) on simple and on some mixed-FI schedules and explores the idea that these rates are determined by the average delay of reinforcement for responses occurring during the response periods that the schedules generate. The effects of reinforcement delay are assumed to be mediated by a hyperbolic delay of reinforcement gradient. The account predicts that (a) running rates on simple FI schedules should increase with increasing rate of reinforcement, in a manner close to that required by Herrnstein's equation, (b) improving temporal control during acquisition should be associated with increasing running rates, (c) two-valued mixed-FI schedules with equiprobable components should produce complex results, with peak rates sometimes being higher on the longer component schedule, and (d) that effects of reinforcement probability on mixed-FI should affect the response rate at the time of the shorter component only. All these predictions were confirmed by data, although effects in some experiments remain outside the scope of the model. In general, delay of reinforcement as a determinant of response rate on FI and related schedules (rather than temporal control on such schedules) seems a useful starting point for a more thorough analysis of some neglected questions about performance on FI and related schedules.

78 FR 47319 - Fee Schedule for Reference Biological Standards and Biological Preparations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Fee Schedule for Reference Biological Standards and Biological Preparations AGENCY: Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS). ACTION: General notice. SUMMARY: The Centers...

75 FR 9614 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-03

... manufacturer of the basic classes of controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to manufacture small quantities of marihuana derivatives for research purposes. In reference to drug code 7360 (Marihuana), the company plans to bulk...

75 FR 64744 - Manufacturer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... manufacturer of the basic classes of controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to manufacture small quantities of marihuana derivatives for research purposes. In reference to drug code 7360 (Marihuana), the company plans to bulk...

76 FR 5799 - Prairie Power, Inc.; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

.... (Midwest ISO) Schedule 2, for reactive supply and voltage control service from certain of its owned... and Midwest ISO requirements for the provision of reactive supply and voltage control under Schedule 2 of the Midwest ISO Open Access Transmission, Energy, and Operating Reserve Markets Tariff, including...

40 CFR 300.920 - Addition of products to Schedule.

Code of Federal Regulations, 2011 CFR

2011-07-01

... manufacturer of his decision in writing. (b) Surface washing agents, surface collecting agents, bioremediation... collecting agent, bioremediation agent, or miscellaneous oil spill control agent to the NCP Product Schedule... collecting agent, bioremediation agent, or miscellaneous oil spill control agent. On the basis of this data...

40 CFR 300.920 - Addition of products to Schedule.

Code of Federal Regulations, 2014 CFR

2014-07-01

... manufacturer of his decision in writing. (b) Surface washing agents, surface collecting agents, bioremediation... collecting agent, bioremediation agent, or miscellaneous oil spill control agent to the NCP Product Schedule... collecting agent, bioremediation agent, or miscellaneous oil spill control agent. On the basis of this data...

40 CFR 300.920 - Addition of products to Schedule.

Code of Federal Regulations, 2012 CFR

2012-07-01

... manufacturer of his decision in writing. (b) Surface washing agents, surface collecting agents, bioremediation... collecting agent, bioremediation agent, or miscellaneous oil spill control agent to the NCP Product Schedule... collecting agent, bioremediation agent, or miscellaneous oil spill control agent. On the basis of this data...

40 CFR 300.920 - Addition of products to Schedule.

Code of Federal Regulations, 2013 CFR

2013-07-01

... manufacturer of his decision in writing. (b) Surface washing agents, surface collecting agents, bioremediation... collecting agent, bioremediation agent, or miscellaneous oil spill control agent to the NCP Product Schedule... collecting agent, bioremediation agent, or miscellaneous oil spill control agent. On the basis of this data...